Please select the eligibility criteria that correspond to the clinical trial below.
Title: Prevention of Cardiovascular Disease With the Vegetarian Diet: the CARDIVEG Study
Brief Summary: The study is a randomized, open, cross-over trial designed to test whether a vegetarian diet would benefit the cardiovascular risk profile of the participants, compared with a Mediterranean diet.


Options:
A: Inclusion Criteria:

* Any coronary artery disease evidence in the past 10 years; or any ischemic stroke or TIA evidence in the past 10 years; or peripheral arterial disease in the past 10 years; or at least one of the following additional risk factors:
* Diabetes Mellitus; Hypertension; Dyslipidemia; Coronary artery disease family history;
* Asymptomatic carotid artery disease;
* Body mass index\> 25 kg/m2 for adults and\> 28 kg/m2 for seniors

Exclusion Criteria:

* Neurocognitive or psychiatric condition;
* Life expectancy less than 6 months (eg, metastatic malignancy or other defined as clinical trial investigators).
* Pregnancy or breast feeding.
* Hepatic impairment defined as elevated liver enzymes above three times the upper limit of normal
* Renal impairment defined as creatinine values higher than 1.5 mg/dL.
B: Inclusion Criteria:

* abdominal obesity

Exclusion Criteria:

* BMI \> 45, previous weight change
C: Inclusion Criteria:

* Male and female subjects over 45 years of age with mild hypercholesterolaemia (TC levels: 200 mg/dl - 230 mg/dl)

Exclusion Criteria:

Subjects with

* Established CVD (coronary heart disease, peripheral arterial disease, aortic aneurysm, or symptomatic carotid artery disease) or T2DM
* Chronic diseases (including liver diseases)
* Pregnancy
* Malignancies
* Unwillingness to participate
D: Inclusion Criteria:

1. Age 18-75 years
2. Willing and able to give informed consent
3. Presence of at least one of the following risk factors for cardiovascular disease (European Society of Cardiology guidelines on cardiovascular disease prevention):

   * BMI \>o= 25 kg/m2
   * Waist circumference \> 88 cm (women) or \> 102 cm (men)
   * Circulating levels of total cholesterol \> 190 mg/dL, non-drug treatment (measured no more than 3 months prior to the start of the study)
   * Circulating levels of LDL cholesterol \> 115 mg/dL, non-drug treatment (measured no more than 3 months prior to the start of the study)
   * Levels of circulating triglycerides \> 150 mg/dL, non-drug treatment (measured no more than 3 months prior to the start of the study)
   * Circulating levels of fasting blood glucose \> 110 and \< 126 mg/dL, non-drug treatment (measured no more than 3 months prior to the start of the study)
4. Wiling to participate in a randomized study comparing two dietary profiles, one of which is a vegetarian dietary pattern
5. Successfully completed 3-day food diary
6. Wiling to be contacted at least twice during the study period to evaluate diet compliance
7. Wiling to provide blood and fecal samples

Exclusion Criteria:

1. Presence of current serious illness or unstable condition that requires physician supervision of diet or physical activity (e.g., recent myocardial infarction, chronic liver disease, inflammatory bowel diseases)
2. Pregnancy or intention to become pregnant in next 18 months
3. Lactation
4. Current or recent (past 6 months) participation in weight loss treatment program or use of weight loss medication
5. Reporting no regular intake of meat, fish, or poultry for past month

Answer: D