Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Naltrexone & SSRI in Alcoholics With Depression/PTSD
Brief Summary: The purpose of this study is to evaluate the efficacy of naltrexone in combination with an SSRI to reduce alcohol consumption in alcoholic patients with comorbid PTSD and depression.

We hypothesize that the combination of naltrexone and SSRI will exhibit a greater decrease in alcohol consumption than that seen with treatment with SSRI alone, or with a combination of another class of antidepressant and naltrexone. We also hypothesize that SSRI will be effective in treating PTSD and depressive symptoms and naltrexone will be well tolerated.


Options:
A: Arm Label: A; Type: ACTIVE_COMPARATOR; Interventions: Other: active venlafaxine and active rTMS-repetitive transcranial magnetic stimulator, Inomed and Alpine Biomed | Arm Label: B; Type: EXPERIMENTAL; Interventions: Other: active rTMS -repetitive transcranial magnetic stimulator, Inomed and Alpine Biomed and sham venlafaxine | Arm Label: C; Type: SHAM_COMPARATOR; Interventions: Other: sham rTMS- repetitive transcranial magnetic stimulator, Inomed and Alpine Biomed and active venlafaxine | Intervention Type: OTHER; Name: active venlafaxine and active rTMS-repetitive transcranial magnetic stimulator, Inomed and Alpine Biomed; Assigned to Arm(s): A | Intervention Type: OTHER; Name: active rTMS -repetitive transcranial magnetic stimulator, Inomed and Alpine Biomed and sham venlafaxine; Assigned to Arm(s): B | Intervention Type: OTHER; Name: sham rTMS- repetitive transcranial magnetic stimulator, Inomed and Alpine Biomed and active venlafaxine; Assigned to Arm(s): C
B: Arm Label: Sertraline; Type: EXPERIMENTAL; Interventions: Drug: sertraline (Zoloft) | Arm Label: Naltrexone; Type: EXPERIMENTAL; Interventions: Drug: naltrexone (Revia) | Arm Label: Nal/Sert; Type: EXPERIMENTAL; Interventions: Drug: naltrexone (Revia), Drug: sertraline (Zoloft) | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: naltrexone (Revia); Assigned to Arm(s): Nal/Sert, Naltrexone | Intervention Type: DRUG; Name: sertraline (Zoloft); Assigned to Arm(s): Nal/Sert, Sertraline | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: Escitalopram plus acamprosate; Type: EXPERIMENTAL; Interventions: Drug: acamprosate, Drug: escitalopram, Behavioral: Medical management | Arm Label: Escitalopram plus placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: escitalopram, Behavioral: Medical management, Drug: Placebo | Intervention Type: DRUG; Name: acamprosate; Assigned to Arm(s): Escitalopram plus acamprosate | Intervention Type: DRUG; Name: escitalopram; Assigned to Arm(s): Escitalopram plus acamprosate, Escitalopram plus placebo | Intervention Type: BEHAVIORAL; Name: Medical management; Assigned to Arm(s): Escitalopram plus acamprosate, Escitalopram plus placebo | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Escitalopram plus placebo
D: Arm Label: Paroxetine and naltrexone; Type: ACTIVE_COMPARATOR; Interventions: Drug: paroxetine, Drug: Naltrexone | Arm Label: paroxetine and placebo; Type: ACTIVE_COMPARATOR; Interventions: Drug: paroxetine, Drug: Placebo | Arm Label: Desipramine and naltrexone; Type: ACTIVE_COMPARATOR; Interventions: Drug: desipramine, Drug: Naltrexone | Arm Label: Desipramine and placebo; Type: ACTIVE_COMPARATOR; Interventions: Drug: desipramine, Drug: Placebo | Intervention Type: DRUG; Name: paroxetine; Assigned to Arm(s): Paroxetine and naltrexone, paroxetine and placebo | Intervention Type: DRUG; Name: desipramine; Assigned to Arm(s): Desipramine and naltrexone, Desipramine and placebo | Intervention Type: DRUG; Name: Naltrexone; Assigned to Arm(s): Desipramine and naltrexone, Paroxetine and naltrexone | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Desipramine and placebo, paroxetine and placebo

Answer: D