Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomized Trial of Hypofractionated Whole Breast Irradiation Versus Conventionally Fractionated Whole Breast Irradiation for Ductal Carcinoma In Situ and Early Invasive Breast Cancer
Brief Summary: This randomized phase II trial studies how well hypofractionated radiation therapy (RT) works compared to standard RT in treating patients with ductal breast carcinoma in situ (DCIS) or early invasive breast cancer. Radiation therapy (RT) uses high energy x-rays to kill tumor cells. Giving higher doses of RT over a shorter period of time may kill more tumor cells and have fewer side effects. It is not yet known if hypofractionated RT is more effective than standard RT in treating breast cancer.


Options:
A: Arm Label: Conventional radiotherapy; Type: ACTIVE_COMPARATOR; Interventions: Radiation: Conventional radiotherapy | Arm Label: Tomotherapy; Type: EXPERIMENTAL; Interventions: Radiation: Tomotherapy | Intervention Type: RADIATION; Name: Conventional radiotherapy; Assigned to Arm(s): Conventional radiotherapy | Intervention Type: RADIATION; Name: Tomotherapy; Assigned to Arm(s): Tomotherapy
B: Arm Label: Arm I (AC, paclitaxel, tamoxifen, aromatase inhibitor); Type: EXPERIMENTAL; Interventions: Drug: Aromatase Inhibition Therapy, Drug: Cyclophosphamide, Drug: Doxorubicin Hydrochloride, Other: Laboratory Biomarker Analysis, Drug: Paclitaxel, Drug: Tamoxifen Citrate | Arm Label: Arm II (AC, paclitaxel, trastuzumab, tamoxifen); Type: EXPERIMENTAL; Interventions: Drug: Aromatase Inhibition Therapy, Drug: Cyclophosphamide, Drug: Doxorubicin Hydrochloride, Other: Laboratory Biomarker Analysis, Drug: Paclitaxel, Drug: Tamoxifen Citrate, Biological: Trastuzumab | Arm Label: Arm III (AC, paclitaxel, trastuzumab, tamoxifen); Type: EXPERIMENTAL; Interventions: Drug: Aromatase Inhibition Therapy, Drug: Cyclophosphamide, Drug: Doxorubicin Hydrochloride, Other: Laboratory Biomarker Analysis, Drug: Paclitaxel, Drug: Tamoxifen Citrate, Biological: Trastuzumab | Intervention Type: DRUG; Name: Aromatase Inhibition Therapy; Assigned to Arm(s): Arm I (AC, paclitaxel, tamoxifen, aromatase inhibitor), Arm II (AC, paclitaxel, trastuzumab, tamoxifen), Arm III (AC, paclitaxel, trastuzumab, tamoxifen) | Intervention Type: DRUG; Name: Cyclophosphamide; Assigned to Arm(s): Arm I (AC, paclitaxel, tamoxifen, aromatase inhibitor), Arm II (AC, paclitaxel, trastuzumab, tamoxifen), Arm III (AC, paclitaxel, trastuzumab, tamoxifen) | Intervention Type: DRUG; Name: Doxorubicin Hydrochloride; Assigned to Arm(s): Arm I (AC, paclitaxel, tamoxifen, aromatase inhibitor), Arm II (AC, paclitaxel, trastuzumab, tamoxifen), Arm III (AC, paclitaxel, trastuzumab, tamoxifen) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Arm I (AC, paclitaxel, tamoxifen, aromatase inhibitor), Arm II (AC, paclitaxel, trastuzumab, tamoxifen), Arm III (AC, paclitaxel, trastuzumab, tamoxifen) | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): Arm I (AC, paclitaxel, tamoxifen, aromatase inhibitor), Arm II (AC, paclitaxel, trastuzumab, tamoxifen), Arm III (AC, paclitaxel, trastuzumab, tamoxifen) | Intervention Type: DRUG; Name: Tamoxifen Citrate; Assigned to Arm(s): Arm I (AC, paclitaxel, tamoxifen, aromatase inhibitor), Arm II (AC, paclitaxel, trastuzumab, tamoxifen), Arm III (AC, paclitaxel, trastuzumab, tamoxifen) | Intervention Type: BIOLOGICAL; Name: Trastuzumab; Assigned to Arm(s): Arm II (AC, paclitaxel, trastuzumab, tamoxifen), Arm III (AC, paclitaxel, trastuzumab, tamoxifen)
C: Arm Label: Arm I (HF-WBI); Type: EXPERIMENTAL; Interventions: Radiation: External Beam Radiation Therapy, Radiation: Hypofractionated Radiation Therapy, Other: Laboratory Biomarker Analysis, Other: Quality-of-Life Assessment, Other: Questionnaire Administration, Radiation: Whole Breast Irradiation | Arm Label: Arm II (CF-WBI); Type: ACTIVE_COMPARATOR; Interventions: Radiation: External Beam Radiation Therapy, Other: Laboratory Biomarker Analysis, Other: Quality-of-Life Assessment, Other: Questionnaire Administration, Radiation: Whole Breast Irradiation | Intervention Type: RADIATION; Name: External Beam Radiation Therapy; Assigned to Arm(s): Arm I (HF-WBI) | Intervention Type: RADIATION; Name: External Beam Radiation Therapy; Assigned to Arm(s): Arm II (CF-WBI) | Intervention Type: RADIATION; Name: Hypofractionated Radiation Therapy; Assigned to Arm(s): Arm I (HF-WBI) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Arm I (HF-WBI), Arm II (CF-WBI) | Intervention Type: OTHER; Name: Quality-of-Life Assessment; Assigned to Arm(s): Arm I (HF-WBI), Arm II (CF-WBI) | Intervention Type: OTHER; Name: Questionnaire Administration; Assigned to Arm(s): Arm I (HF-WBI), Arm II (CF-WBI) | Intervention Type: RADIATION; Name: Whole Breast Irradiation; Assigned to Arm(s): Arm I (HF-WBI) | Intervention Type: RADIATION; Name: Whole Breast Irradiation; Assigned to Arm(s): Arm II (CF-WBI)
D: Arm Label: Hypofractionated whole breast radiation; Type: EXPERIMENTAL; Interventions: Radiation: Hypofractionated whole breast radiation schedule | Arm Label: Conventional whole breast radiation; Type: ACTIVE_COMPARATOR; Interventions: Radiation: Conventional whole breast radiation schedule | Intervention Type: RADIATION; Name: Conventional whole breast radiation schedule; Assigned to Arm(s): Conventional whole breast radiation | Intervention Type: RADIATION; Name: Hypofractionated whole breast radiation schedule; Assigned to Arm(s): Hypofractionated whole breast radiation

Answer: C