Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A GCIG Intergroup Multicenter Phase III Trial of Open Label Carboplatin and Paclitaxel +/- NCI-Supplied Agent: Bevacizumab (NSC #704865) Compared With Oxaliplatin and Capecitabine +/- Bevacizumab as First Line Chemotherapy in Patients With Mucinous Epithelial Ovarian or Fallopian Tube Cancer (MEOC)
Brief Summary: This randomized phase III trial studies carboplatin given together with paclitaxel with or without bevacizumab to see how well it works compared with oxaliplatin given together with capecitabine with or without bevacizumab as first-line therapy in treating patients with newly diagnosed stage II-IV, or recurrent (has come back) stage I epithelial ovarian or fallopian tube cancer. Drugs used in chemotherapy, such as carboplatin, paclitaxel, oxaliplatin, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, may block tumor growth in different ways by targeting certain cells. It is not yet known which regimen of combination chemotherapy given together with or without bevacizumab is more effective in treating epithelial ovarian cancer or fallopian tube cancer.


Options:
A: Arm Label: Arm I (carboplatin and paclitaxel); Type: EXPERIMENTAL; Interventions: Drug: Carboplatin, Other: Laboratory Biomarker Analysis, Drug: Paclitaxel, Other: Quality-of-Life Assessment | Arm Label: Arm II (oxaliplatin and capecitabine); Type: EXPERIMENTAL; Interventions: Drug: Capecitabine, Other: Laboratory Biomarker Analysis, Drug: Oxaliplatin, Other: Quality-of-Life Assessment | Arm Label: Arm III (carboplatin, paclitaxel, bevacizumab); Type: EXPERIMENTAL; Interventions: Biological: Bevacizumab, Drug: Carboplatin, Other: Laboratory Biomarker Analysis, Drug: Paclitaxel, Other: Quality-of-Life Assessment | Arm Label: Arm IV (oxaliplatin, capecitabine, bevacizumab); Type: EXPERIMENTAL; Interventions: Biological: Bevacizumab, Drug: Capecitabine, Other: Laboratory Biomarker Analysis, Drug: Oxaliplatin, Other: Quality-of-Life Assessment | Intervention Type: BIOLOGICAL; Name: Bevacizumab; Assigned to Arm(s): Arm III (carboplatin, paclitaxel, bevacizumab), Arm IV (oxaliplatin, capecitabine, bevacizumab) | Intervention Type: DRUG; Name: Capecitabine; Assigned to Arm(s): Arm II (oxaliplatin and capecitabine), Arm IV (oxaliplatin, capecitabine, bevacizumab) | Intervention Type: DRUG; Name: Carboplatin; Assigned to Arm(s): Arm I (carboplatin and paclitaxel), Arm III (carboplatin, paclitaxel, bevacizumab) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Arm I (carboplatin and paclitaxel), Arm II (oxaliplatin and capecitabine), Arm III (carboplatin, paclitaxel, bevacizumab), Arm IV (oxaliplatin, capecitabine, bevacizumab) | Intervention Type: DRUG; Name: Oxaliplatin; Assigned to Arm(s): Arm II (oxaliplatin and capecitabine), Arm IV (oxaliplatin, capecitabine, bevacizumab) | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): Arm I (carboplatin and paclitaxel), Arm III (carboplatin, paclitaxel, bevacizumab) | Intervention Type: OTHER; Name: Quality-of-Life Assessment; Assigned to Arm(s): Arm I (carboplatin and paclitaxel), Arm II (oxaliplatin and capecitabine), Arm III (carboplatin, paclitaxel, bevacizumab), Arm IV (oxaliplatin, capecitabine, bevacizumab)
B: Arm Label: Experimental; Type: EXPERIMENTAL; Interventions: Drug: Sorafenib | Intervention Type: DRUG; Name: Sorafenib; Assigned to Arm(s): Experimental
C: Arm Label: gemcitabine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Gemcitabine | Arm Label: Gemcitabine + pazopanib; Type: EXPERIMENTAL; Interventions: Drug: Gemcitabine, Drug: pazopanib | Intervention Type: DRUG; Name: Gemcitabine; Assigned to Arm(s): Gemcitabine + pazopanib, gemcitabine | Intervention Type: DRUG; Name: pazopanib; Assigned to Arm(s): Gemcitabine + pazopanib
D: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Paclitaxel, Drug: AMG 386 Placebo, Drug: Carboplatin | Arm Label: AMG 386; Type: ACTIVE_COMPARATOR; Interventions: Drug: AMG 386, Drug: Paclitaxel, Drug: Carboplatin | Intervention Type: DRUG; Name: AMG 386; Assigned to Arm(s): AMG 386 | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): AMG 386, Placebo | Intervention Type: DRUG; Name: AMG 386 Placebo; Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: Carboplatin; Assigned to Arm(s): AMG 386, Placebo

Answer: A