Please select the eligibility criteria that correspond to the clinical trial below.
Title: Computer-based Alcohol Reduction Intervention for Alcohol-using HIV/HCV+ Russian Women in Clinical Care
Brief Summary: The study harnessed the multidisciplinary expertise of our research team to develop a brief, computer-based, alcohol reduction intervention tailored for HIV/HCV co-infected women and evaluate its efficacy. The intervention, if effective, may be an efficient and cost-effective alcohol reduction strategy, that is scalable and can be readily disseminated and integrated in clinical care at other AIDS Centres in Russia to enhance women's health and reduce HIV/HCV transmission risk.


Options:
A: Inclusion Criteria:

* Men and women older than 18 years and 50 years
* Achieving a moderate risk score in the ASSIST screening questionnaire.
* Without any similar intervention in the last 3 months. (ie. AUDIT test).

Exclusion Criteria:

* Pregnant women.
* Users with cognitive disabilities.
* Users with language and communication disabilities.
B: Inclusion Criteria:

* Initial inclusion criteria for overall enrollment (into either the Cohort or RCT study) will be:

  * HIV positive
  * Receiving HIV treatment services at one of the two study clinics
  * Current hazardous alcohol use, defined as an AUDIT score of ≥8 for men and ≥ 4 for women
  * Provides informed consent

Secondary inclusion for enrollment into the RCT will be:

* AUDIT scores that indicate a moderate-to-severe AUD (≥12 for women; ≥16 among men)
* AND/OR: meeting validated symptom criteria for depression (≥16 on Center for Epidemiological Studies-Depression (CES-D), trauma/anxiety (≥2.5 on HTQ), and/or substance use (≥27 for any non-tobacco/alcohol substance on ASSIST)

Exclusion Criteria:

* HIV negative
* Not receiving care at one of the study clinics
* Currently psychotic or actively suicidal
* Unable to provide informed consent
C: Inclusion Criteria:

* HIV-infected adult (≥18 years) prescribed antiretroviral therapy (ART) for at least 6 months;
* Current heavy alcohol use (AUDIT-C positive for prior 3 month drinking and positive EtG urine test);
* Positive tuberculin skin test (TST) (≥5 mm induration);
* AST and ALT \<2x the upper limit of normal (ULN);
* Fluent in Runyankole or English;
* No history of active TB, TB treatment, or TB preventive therapy;
* Lives within 2-hour travel time or 60 km of the study site.

Exclusion Criteria:

* Prescribed nevirapine (NVP, an ART drug that is declining in usage due to high risk for hepatotoxicity);
* Plans to move out of the catchment area within 6 months;
* Prescribed anti-convulsion medications or history of recurring seizures;
* ALT or AST elevations (\>2X ULN);
* Suspected or confirmed active TB as determined by symptom screening and followed by chest X-ray and sputum testing;
* History of prior active TB treatment or prior IPT.
* Pregnant at time of screening
D: Inclusion Criteria:

* female;
* receiving HIV medical care at the AIDS Center;
* chart-documented HIV and chronic HCV infection;
* currently prescribed an antiretroviral (ARV) regimen;
* medically, cognitively, and psychologically capable of study participation;
* laboratory-confirmed recent alcohol use as detected by a Ethylglucuronide (EtG) analysis or self-reported alcohol use

Exclusion Criteria:

* not identifying as biological female
* not HIV and HCV positive
* no laboratory-confirmed or self-reported
* not willing to participate in the trial
* not able to participate in the trial due to medical, cognitive, or psychological issues

Answer: D