Please select the eligibility criteria that correspond to the clinical trial below.
Title: The Impact of Exercise on Hand Function, on Activities of Daily Living (ADLs) Performance and Quality of Life of Patients With Systemic Lupus Erythematosus (SLE)
Brief Summary: A total of 240 consecutive SLE patients fulfilling the SLICC classification criteria was evaluated. Sixty two patients who met the inclusion criteria were randomly assigned to the exercise group (n=32) or the control group (n=30).

Patients in the exercise group performed a program of strengthening, stretching and resistance upper limbs exercises, of 30 minutes duration daily, for 12 weeks. Performance of daily activities was evaluated with the DASH and HAQ questionnaires, grip and pinch strength with the Jamar dynamometer and pinch gauge tools respectively, dexterity with the Purdue pegboard test and the quality of life with the LUPUSQoL questionnaire at 0, 6, 12 (end of the exercise program) and 24 weeks for both groups. SLE activity and cumulative organ damage were evaluated with the SLE disease activity index 2000 (SLEDAI-2K) and SLICC/ACR-DI, respectively.


Options:
A: Inclusion Criteria:

* Positive ANA-titer (≥ 1:80) or Anti-dsDNA (≥ 200 IU/ml) or Highly avid-dsDNA autoantibody (≥ 30 IU/ml)
* Stable immunosuppressive therapy more than 30 days before beginning of the study with steroid (0-20 mg/day) or other immunosuppressive medication like Hydroxchloroquin, Chloroquin, Azathioprin, Methotrexat, Mycophenolatmofetil, Cyclosporin, Belimumab, Rituximab

Exclusion Criteria:

* Pregnancy, Active lupus nephritits, Physical activity more than two times a week
B: Inclusion Criteria:

* SLE patients fulfilling the SLICC classification criteria
* Upper limb arthralgias
* DASH score\>10
* Stable drug regimen≥3 months

Exclusion Criteria:

* Hand fracture or surgery in last 6 months
* Physiotherapy program in last month
C: Inclusion Criteria:

* female systemic lupus erythematosus patients
* 18 to 45 years of age
* Fulfilled at least four criteria classification for lupus (ACR criteria, 1997) - Signed the consent form approved by the ethics committee of the institution

Exclusion Criteria:

* Hemoglobin \< 10 mg/dL
* Neuropsychiatric, pulmonary, articular or vascular damage that would prevent the practice of exercise
* Coronary disease or heart failure, functional class ≥ II
* Pulmonary hypertension
* Uncontrolled hypertension
* Creatinine ≥ 1.4 mg/dL
* Body mass index (BMI) ≥ 35 kg/m2
* Diabetes mellitus
* Uncontrolled hypothyroidism
* Smoking in the last 12 months
* Pregnancy
* Menopause
* Use of statins in the last three months
* Practice of physical exercise in past three months
* Overlap with other autoimmune rheumatic diseases, except antiphospholipid syndrome.
D: Primary Inclusion Criteria

* Clinical diagnosis of SLE
* "Active" SLE disease
* On a stable SLE treatment regimen
* History of measurable autoantibodies

Primary Exclusion Criteria

* Received a non-FDA approved investigational agent within last 28 days
* Cyclosporin, intravenous immunoglobulin (IVIG) or plasmapheresis within last 90 days
* Active lupus nephritis requiring hemodialysis, cyclophosphamide (Cytoxan™), or high-dose prednisone (\> 100 mg/day) within last 90 days
* Active central nervous system (CNS) lupus requiring therapeutic intervention within last 60 days
* History of renal transplant
* History of chronic infection that has been active within last 6 months, herpes zoster within last 90 days or any infection requiring hospitalization or intravenous medication within last 60 days
* History of hypogammaglobulinemia or immunoglobulin A (IgA) deficiency
* Human immunodeficiency virus (HIV), Hepatitis B, Hepatitis C

Answer: B