Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Study of Rucaparib as Switch Maintenance Following Platinum-Based Chemotherapy in Patients With Platinum-Sensitive, High-Grade Serous or Endometrioid Epithelial Ovarian, Primary Peritoneal or Fallopian Tube Cancer ( ARIEL3 )
Brief Summary: Patients enrolled into this study will be stratified into 3 groups based on gene mutations identified in their tumor tissue. The purpose of this study is to evaluate patient response to maintenance treatment with rucaparib versus placebo. Response to treatment will be analyzed based on homologous recombination (HR) status of tumor samples.


Options:
A: Arm Label: Bevacizumab+TC; Type: EXPERIMENTAL; Interventions: Drug: Bevacizumab, Drug: TC:paclitaxel + carboplatin | Arm Label: TC; Type: ACTIVE_COMPARATOR; Interventions: Drug: TC:paclitaxel + carboplatin | Intervention Type: DRUG; Name: Bevacizumab; Assigned to Arm(s): Bevacizumab+TC | Intervention Type: DRUG; Name: TC:paclitaxel + carboplatin; Assigned to Arm(s): Bevacizumab+TC, TC
B: Arm Label: AMG 386; Type: EXPERIMENTAL; Interventions: Drug: AMG 386, Drug: Paclitaxel | Arm Label: AMG 386 Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: AMG 386 Placebo, Drug: Paclitaxel | Intervention Type: DRUG; Name: AMG 386; Assigned to Arm(s): AMG 386 | Intervention Type: DRUG; Name: AMG 386 Placebo; Assigned to Arm(s): AMG 386 Placebo | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): AMG 386 | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): AMG 386 Placebo
C: Arm Label: Arm I (platinum-based chemotherapy); Type: ACTIVE_COMPARATOR; Interventions: Drug: Carboplatin, Procedure: Computed Tomography, Procedure: Echocardiography Test, Drug: Gemcitabine, Drug: Gemcitabine Hydrochloride, Other: Laboratory Biomarker Analysis, Procedure: Magnetic Resonance Imaging, Procedure: Multigated Acquisition Scan, Drug: Paclitaxel, Drug: Pegylated Liposomal Doxorubicin Hydrochloride, Other: Quality-of-Life Assessment | Arm Label: Arm II (olaparib); Type: EXPERIMENTAL; Interventions: Procedure: Biospecimen Collection, Procedure: Computed Tomography, Procedure: Echocardiography Test, Other: Laboratory Biomarker Analysis, Procedure: Magnetic Resonance Imaging, Procedure: Multigated Acquisition Scan, Drug: Olaparib, Other: Pharmacological Study, Other: Quality-of-Life Assessment | Arm Label: Arm III (olaparib, cediranib maleate); Type: EXPERIMENTAL; Interventions: Procedure: Biospecimen Collection, Drug: Cediranib Maleate, Procedure: Computed Tomography, Procedure: Echocardiography Test, Other: Laboratory Biomarker Analysis, Procedure: Magnetic Resonance Imaging, Procedure: Multigated Acquisition Scan, Drug: Olaparib, Other: Pharmacological Study, Other: Quality-of-Life Assessment | Intervention Type: PROCEDURE; Name: Biospecimen Collection; Assigned to Arm(s): Arm II (olaparib), Arm III (olaparib, cediranib maleate) | Intervention Type: DRUG; Name: Carboplatin; Assigned to Arm(s): Arm I (platinum-based chemotherapy) | Intervention Type: DRUG; Name: Cediranib Maleate; Assigned to Arm(s): Arm III (olaparib, cediranib maleate) | Intervention Type: PROCEDURE; Name: Computed Tomography; Assigned to Arm(s): Arm I (platinum-based chemotherapy), Arm II (olaparib), Arm III (olaparib, cediranib maleate) | Intervention Type: PROCEDURE; Name: Echocardiography Test; Assigned to Arm(s): Arm I (platinum-based chemotherapy), Arm II (olaparib), Arm III (olaparib, cediranib maleate) | Intervention Type: DRUG; Name: Gemcitabine; Assigned to Arm(s): Arm I (platinum-based chemotherapy) | Intervention Type: DRUG; Name: Gemcitabine Hydrochloride; Assigned to Arm(s): Arm I (platinum-based chemotherapy) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Arm I (platinum-based chemotherapy), Arm II (olaparib), Arm III (olaparib, cediranib maleate) | Intervention Type: PROCEDURE; Name: Magnetic Resonance Imaging; Assigned to Arm(s): Arm I (platinum-based chemotherapy), Arm II (olaparib), Arm III (olaparib, cediranib maleate) | Intervention Type: PROCEDURE; Name: Multigated Acquisition Scan; Assigned to Arm(s): Arm I (platinum-based chemotherapy), Arm II (olaparib), Arm III (olaparib, cediranib maleate) | Intervention Type: DRUG; Name: Olaparib; Assigned to Arm(s): Arm II (olaparib), Arm III (olaparib, cediranib maleate) | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): Arm I (platinum-based chemotherapy) | Intervention Type: DRUG; Name: Pegylated Liposomal Doxorubicin Hydrochloride; Assigned to Arm(s): Arm I (platinum-based chemotherapy) | Intervention Type: OTHER; Name: Pharmacological Study; Assigned to Arm(s): Arm II (olaparib), Arm III (olaparib, cediranib maleate) | Intervention Type: OTHER; Name: Quality-of-Life Assessment; Assigned to Arm(s): Arm I (platinum-based chemotherapy), Arm II (olaparib), Arm III (olaparib, cediranib maleate)
D: Arm Label: Rucaparib; Type: EXPERIMENTAL; Interventions: Drug: Rucaparib | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Rucaparib; Assigned to Arm(s): Rucaparib | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo

Answer: D