Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: RAndomized Study of Basal Bolus Insulin Therapy in the Inpatient Management of Patients With Type 2 Diabetes Undergoing General Surgery (RABBIT 2 Surgery)
Brief Summary: High blood glucose levels in surgical patients with diabetes are associated with increased risk of medical complications and death. Improved glucose control with insulin injections may improve clinical outcome and prevent some of the hospital complications. In patients who have undergone surgery, high blood glucose increases the risk of wound infection, kidney failure and death. It is not known; however, what is the best insulin regimen in patients who will undergo surgery. The use of repeated injections of regular insulin is commonly used for glucose control in hospitalized patients with diabetes. Recently, the combination of Lantus® and Apidra® insulins has been shown to improve glucose control with lower rate of hypoglycemia (low blood sugar). We hypothesize that in patients with type 2 diabetes admitted to general surgery wards, treatment with once daily glargine (Lantus) plus supplemental glulisine insulin (Apidra®) will produce better glycemic control and a lower rate of hospital complications than treatment with regular insulin per sliding scale (SSRI). The present study aims to determine which insulin treatment is best for glucose control in hospitalized patients with diabetes. Glargine and glulisine insulins are approved for use in the treatment of patients with diabetes by the FDA.

Subjects included in the study will have type 2 diabetes and be admitted to Grady Memorial Hospital, Veterans Administration Medical Center, and Emory University Hospital, Atlanta, Georgia. A total of \~94 patients will be recruited at each institution.

A post-hoc cost analysis of hospitalization costs and charges of the Rabbit surgery trial will be completed in order to determine differences in hospitalization cost between basal bolus insulin and SSI regimen.


Options:
A: Arm Label: Bedtime supplementation; Type: ACTIVE_COMPARATOR; Interventions: Drug: Bedtime insulin Aspart (Novolog) | Arm Label: no bedtime supplementation; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DRUG; Name: Bedtime insulin Aspart (Novolog); Assigned to Arm(s): Bedtime supplementation
B: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: Insulin glargine, Drug: Insulin glulisine | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Drug: Regular insulin | Intervention Type: DRUG; Name: Insulin glargine; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Regular insulin; Assigned to Arm(s): 2 | Intervention Type: DRUG; Name: Insulin glulisine; Assigned to Arm(s): 1
C: Arm Label: sliding scale regular insulin; Type: ACTIVE_COMPARATOR; Interventions: Drug: sliding scale regular insulin | Arm Label: glargine insulin and glulisine insulin; Type: ACTIVE_COMPARATOR; Interventions: Drug: glargine basal insulin and glulisine prandial insulin | Intervention Type: DRUG; Name: sliding scale regular insulin; Assigned to Arm(s): sliding scale regular insulin | Intervention Type: DRUG; Name: glargine basal insulin and glulisine prandial insulin; Assigned to Arm(s): glargine insulin and glulisine insulin
D: Arm Label: Basal Plus Regimen; Type: EXPERIMENTAL; Interventions: Drug: Basal Plus | Arm Label: Basal Bolus; Type: EXPERIMENTAL; Interventions: Drug: Basal Bolus | Arm Label: sliding scale regular insulin (SSRI); Type: ACTIVE_COMPARATOR; Interventions: Drug: sliding scale regular insulin (SSRI) | Intervention Type: DRUG; Name: sliding scale regular insulin (SSRI); Assigned to Arm(s): sliding scale regular insulin (SSRI) | Intervention Type: DRUG; Name: Basal Bolus; Assigned to Arm(s): Basal Bolus | Intervention Type: DRUG; Name: Basal Plus; Assigned to Arm(s): Basal Plus Regimen

Answer: B