Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized Controlled Study on the Incretin Effect, Cognitive Function and Controlled Fasting During Bed Rest in Healthy Male Volunteers
Brief Summary: Bed rest produces insulin resistance in healthy volunteers. In this study the investigators aim to investigate the effect of 8 days bed rest on the incretin effect and how alternate daily fasting affects cognitive function and the insulin resistance produced by bed rest.

The subjects will be randomized to either 3 meals a day (isocaloric diet), alternate daily fasting or one meal/day every second day (25% of daily calorie need) and four meals/day every second (175% of daily calorie need).

The investigators hypothesize:

1. Bed rest reduces the incretin effect
2. Alternate daily fasting improves the cognitive function (memory and concentration) compared to isocaloric diet
3. Alternate daily fasting reduces insulin resistance produced by bed rest compared to isocaloric diet


Options:
A: Arm Label: Control group; Type: OTHER; Interventions: Other: control group | Arm Label: Intermittent Fasting group; Type: EXPERIMENTAL; Interventions: Other: Intermittent Fasting group | Intervention Type: OTHER; Name: Intermittent Fasting group; Assigned to Arm(s): Intermittent Fasting group | Intervention Type: OTHER; Name: control group; Assigned to Arm(s): Control group
B: Arm Label: Alternate day fasting; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Alternate day fasting | Arm Label: control group; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: Alternate day fasting; Assigned to Arm(s): Alternate day fasting
C: Arm Label: Isocaloric diet; Type: ACTIVE_COMPARATOR; Interventions: Other: Bed rest, Other: OGTT, Other: IVGTT, Other: Cognitive testing, Other: Muscle and fat biopsies, Other: Dual-energy X-ray Absorptiometry (DXA) scan, Other: MRI | Arm Label: Alternate daily fasting; Type: ACTIVE_COMPARATOR; Interventions: Other: Bed rest, Other: OGTT, Other: IVGTT, Other: Cognitive testing, Other: Muscle and fat biopsies, Other: Dual-energy X-ray Absorptiometry (DXA) scan, Other: MRI | Intervention Type: OTHER; Name: Bed rest; Assigned to Arm(s): Alternate daily fasting, Isocaloric diet | Intervention Type: OTHER; Name: OGTT; Assigned to Arm(s): Alternate daily fasting, Isocaloric diet | Intervention Type: OTHER; Name: IVGTT; Assigned to Arm(s): Alternate daily fasting, Isocaloric diet | Intervention Type: OTHER; Name: Cognitive testing; Assigned to Arm(s): Alternate daily fasting, Isocaloric diet | Intervention Type: OTHER; Name: Muscle and fat biopsies; Assigned to Arm(s): Alternate daily fasting, Isocaloric diet | Intervention Type: OTHER; Name: Dual-energy X-ray Absorptiometry (DXA) scan; Assigned to Arm(s): Alternate daily fasting, Isocaloric diet | Intervention Type: OTHER; Name: MRI; Assigned to Arm(s): Alternate daily fasting, Isocaloric diet
D: Arm Label: Intermittent Energy Restriction; Type: EXPERIMENTAL; Interventions: Behavioral: Intermittent Energy Restriction | Arm Label: Continuous Energy Restriction; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Continuous Energy Restriction | Intervention Type: BEHAVIORAL; Name: Intermittent Energy Restriction; Assigned to Arm(s): Intermittent Energy Restriction | Intervention Type: BEHAVIORAL; Name: Continuous Energy Restriction; Assigned to Arm(s): Continuous Energy Restriction

Answer: C