Please select the eligibility criteria that correspond to the clinical trial below.
Title: Childhood Depression: Remission and Relapse
Brief Summary: This study will determine the optimal length of continuation treatment with fluoxetine for children and adolescents with major depressive disorder, as well as the factors that may contribute to positive response during acute and continuation treatment.


Options:
A: Inclusion Criteria:

* Male or Female outpatients between 12-17 years of age
* Primary diagnosis of major depressive disorder (MDD)
* Children's Depression Rating Scale-Revised (CDRS-R) score of 40 or greater
* Clinical Global Impressions-Severity (CGI-S) score of 4 or greater

Exclusion Criteria:

* Current (past 3 months) principal Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Text Revision (DSM-IV-TR) based diagnosis of an axis disorder other than major depressive disorder (MDD) that is the primary focus of treatment.
* History of suicidal behavior, or requires precaution against suicide
* Not generally healthy medical condition
* Seizure disorder
B: Inclusion Criteria:

* Male or female inpatients or outpatients, 10-17 years of age, who have not reached their 18th birthday prior to screening. Patient must weigh at least 20 kilograms (kg) at screening.
* Must meet diagnostic criteria for current major depressive episode of Bipolar I Disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Version (DSM-IV-TR) and confirmed by Kiddie Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present and Lifetime (K-SADS-PL)
* Patients entering the study will also be scored by the Children's Depression Rating Scale-Revised (CDRS-R) (entry score of greater than or equal to 40) as well as the adolescent-structured Young Mania Rating Scale (YMRS) (entry score of less than or equal to 15 with YMRS Item 1 \[elevated mood\] score less than equal to 2).

Exclusion Criteria:

* Patients will be excluded if they are, in the opinion of the investigator, actively suicidal
* Have an acute, serious or unstable medical condition
* Have clinically significant laboratory abnormalities
* Have had one or more seizures of unclear etiology
* Have a current or lifetime diagnosis of any of the following according to DSM-IV criteria: Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder, Delusional Disorder, Psychotic Disorder Not Otherwise Specified, Delirium of any type, Amnestic Disorder, any Substance-Induced Disorder, or any Psychotic Disorder due to a General Medical Condition, unless there is substantive reason to believe patient was misdiagnosed
C: Inclusion Criteria:

* Currently being treated on an outpatient basis
* Currently attending school
* Diagnosis of non-psychotic major depressive disorder (MDD)
* Duration of illness is at least 4 weeks
* In good general medical health
* Normal intelligence

Exclusion Criteria:

* Lifetime history of any psychotic disorder, including psychotic depression
* Diagnosis of bipolar I or II disorder
* History of alcohol or substance abuse or dependence within 6 months of study entry
* Lifetime history of anorexia nervosa or bulimia
* Pregnant or breastfeeding
* Does not agree to use an effective form of contraception (i.e., IUD, birth control pills, or barrier devices)
* Any chronic medical illness requiring regular medication
* Currently taking medication with psychotropic effects (i.e., anticonvulsants, steroids, etc.), other than stable stimulant treatment
* A first degree relative has bipolar I disorder
* Previous adequate treatment with fluoxetine was ineffective (defined as at least 20 mg/day for 4 weeks)
D: Inclusion Criteria:

* Clinical diagnosis of major depressive disorder
* Must be able to swallow tablets
* Must be at least 18 years of age.

Exclusion Criteria:

* Clinical diagnosis of other psychiatric disorders
* Significant risk of suicide
* Unstable medical conditions.

Answer: C