Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: The Impact of Different Treatment Strategies on the Transmission Dynamics of Soil-transmitted Helminths: a Cluster Randomised Trial in Kenya
Brief Summary: The mainstay of control of soil-transmitted helminths (STH) is school-based deworming but recent modelling has highlights that in all but low very transmission settings, the treatment of school-aged children is unlikely to interrupt transmission, and that new treatment strategies are required. This study seeks to answer the question: is it possible to interrupt the transmission of STH and if so, what is the most cost-effective treatment strategy and delivery system to achieve this goal? In this study, two paired community cluster randomised trials in different settings in Kenya will evaluate the impact and cost-effectiveness of annual school-based deworming, annual community-based deworming, and biannual community-based deworming. The interventions are (i) annual mass anthelmintic treatment delivered either to pre-school and school-aged children, as part of a national school-based deworming programme, or to the entire community delivered by community health workers. The primary outcome measure is the prevalence of hookworm infection (the most common STH species), assessed by periodic cross-sectional, age-stratified parasitological surveys. Secondary outcomes include intensity of hookworm, prevalence and intensity of Ascaris lumbricoides, treatment coverage, and among a randomly selected sub-sample of participants who will be followed longitudinally, worm burden and proportion of eggs unfertilised. A nested process evaluation, using semi-structured interviews, focus group discussions and a stakeholder analysis will investigate the community acceptability, feasibility given the local and regional health system structures and processes, and scale-up of the interventions.


Options:
A: Arm Label: 1 dose, Albendazole , tablet; Type: ACTIVE_COMPARATOR; Interventions: Drug: albendazole | Arm Label: 2 doses, albendazole, tablet; Type: ACTIVE_COMPARATOR; Interventions: Drug: albendazole | Arm Label: 3 doses albendazole, 400mg, tablet; Type: ACTIVE_COMPARATOR; Interventions: Drug: albendazole | Intervention Type: DRUG; Name: albendazole; Assigned to Arm(s): 3 doses albendazole, 400mg, tablet | Intervention Type: DRUG; Name: albendazole; Assigned to Arm(s): 1 dose, Albendazole , tablet | Intervention Type: DRUG; Name: albendazole; Assigned to Arm(s): 2 doses, albendazole, tablet
B: Arm Label: Subjects; Type: EXPERIMENTAL; Interventions: Drug: Albendazole Pill 400mg (GSK) | Intervention Type: DRUG; Name: Albendazole Pill 400mg (GSK); Assigned to Arm(s): Subjects
C: Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: vitamin A supplement; Type: ACTIVE_COMPARATOR; Interventions: Drug: vitamin A supplements | Intervention Type: DRUG; Name: vitamin A supplements; Assigned to Arm(s): vitamin A supplement | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): placebo
D: Arm Label: Annual school-based deworming; Type: ACTIVE_COMPARATOR; Interventions: Drug: albendazole | Arm Label: Annual community-based deworming; Type: EXPERIMENTAL; Interventions: Drug: albendazole | Arm Label: Biannual; Type: EXPERIMENTAL; Interventions: Drug: albendazole | Intervention Type: DRUG; Name: albendazole; Assigned to Arm(s): Annual community-based deworming, Annual school-based deworming, Biannual

Answer: D