Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Observational, Cross-over Study of the Positive Distending Pressure Generated by Humidified High Flow Nasal Cannula as Compared to Nasal Continuous Positive Airway Pressure
Brief Summary: The specific aims of this study are to evaluate the amount of high flow nasal cannula (HFNC) gas flow required to generate an equivalent positive distending pressure as that provided by nasal continuous positive airway pressure (NCPAP) of 6 cm H2O, assess the relationships between positive distending pressure, gas flow, oxygen requirement, and patient weight, and lastly, develop an appropriate protocol to be used in the NICU for transitioning patients from NCPAP to an equivalent amount of HFNC.


Options:
A: Arm Label: high flow nasal cannula (HFNC); Type: ACTIVE_COMPARATOR; Interventions: Device: nasal continuous positive airway pressure / nasal positive pressure ventilation (NCPAP/NPPV) and high flow nasal cannula (HFNC) devices | Arm Label: nasal continuous positive airway pressure / nasal positive pressure ventilation (NCPAP/NPPV); Type: ACTIVE_COMPARATOR; Interventions: Device: nasal continuous positive airway pressure / nasal positive pressure ventilation (NCPAP/NPPV) and high flow nasal cannula (HFNC) devices | Intervention Type: DEVICE; Name: nasal continuous positive airway pressure / nasal positive pressure ventilation (NCPAP/NPPV) and high flow nasal cannula (HFNC) devices; Assigned to Arm(s): high flow nasal cannula (HFNC), nasal continuous positive airway pressure / nasal positive pressure ventilation (NCPAP/NPPV)
B: Arm Label: High flow nasal cannula (HFNC); Type: EXPERIMENTAL; Interventions: Device: Treatment strategy: Non-invasive respiratory support delivered via high flow nasal cannula | Arm Label: Continuous positive airway pressure (CPAP); Type: ACTIVE_COMPARATOR; Interventions: Device: Treatment strategy: Non-invasive respiratory support delivered via continuous positive airway pressure | Intervention Type: DEVICE; Name: Treatment strategy: Non-invasive respiratory support delivered via high flow nasal cannula; Assigned to Arm(s): High flow nasal cannula (HFNC) | Intervention Type: DEVICE; Name: Treatment strategy: Non-invasive respiratory support delivered via continuous positive airway pressure; Assigned to Arm(s): Continuous positive airway pressure (CPAP)
C: Intervention Type: DEVICE; Name: High Flow Nasal Cannula; Assigned to Arm(s): N/A
D: Arm Label: bubble CPAP; Type: EXPERIMENTAL; Interventions: Procedure: Bubble continuous positive airway pressure | Arm Label: High flow air/ oxygen mix; Type: EXPERIMENTAL; Interventions: Procedure: Humidified high flow air / O2 mix at 2 l/kg/min | Arm Label: Standard O2 supplementation by nasal prongs; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Standard O2 supplementation by nasal cannula at 0.5 - 2 l/min | Intervention Type: PROCEDURE; Name: Bubble continuous positive airway pressure; Assigned to Arm(s): bubble CPAP | Intervention Type: PROCEDURE; Name: Humidified high flow air / O2 mix at 2 l/kg/min; Assigned to Arm(s): High flow air/ oxygen mix | Intervention Type: PROCEDURE; Name: Standard O2 supplementation by nasal cannula at 0.5 - 2 l/min; Assigned to Arm(s): Standard O2 supplementation by nasal prongs

Answer: C