Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: The Effect of Non-Surgical Periodontal Therapy on Glycemic Control and Bacterial Levels in a Mexican-American Population With Type 2 DiabetesS
Brief Summary: Type 2 diabetes mellitus (T2DM) has become a significant pandemic with more than 7% of the population in the United States affected. Moreover, up to one-third of these individuals may not be aware of the diagnosis and, are not involved in treatment. In the Mexican-American population, prevalence rates may be up to 50%. Contributing factors such as poor education, low household income, language barriers and restricted access to medical services may increase this prevalence. The association between periodontal disease and diabetes has been well documented; however, interventional studies have resulted in conflicting conclusions on improvements in glycemic control following periodontal therapy.

Diabetes and periodontal disease share common pathways in pathogenesis, such as their polygenic nature and immunoregulatory dysfunction. To answer these questions, we, the investigators, propose this randomized controlled trial designed to elucidate how treatment of periodontal disease can be used for preventive and therapeutic purposes in a diabetic population as well as to study the role of IL-1 gene cluster polymorphisms as a risk factor for the presence of periodontitis in a Hispanic T2DM population. Our central hypothesis is that the Mexican-American T2DM population in Texas is at risk for an increased presence and severity of periodontal disease due to the presence of Il-1 gene cluster polymorphisms; furthermore we suggest that providing non-surgical periodontal therapy to this group will decrease the bacterial load associated with disease and as a consequence, will improve glycemic control as measured by HbA1c values. Our long-term goal is to study risk factors associated with the presence of periodontal disease and to understand how the treatment of periodontal disease can be used for preventive and therapeutic purposes in a Hispanic type 2 diabetic population.


Options:
A: Arm Label: Nonsurgical periodontal therapy; Type: EXPERIMENTAL; Interventions: Procedure: Nonsurgical periodontal therapy, Procedure: Oral hygiene instructions | Arm Label: Oral hygiene instructions; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Oral hygiene instructions | Intervention Type: PROCEDURE; Name: Nonsurgical periodontal therapy; Assigned to Arm(s): Nonsurgical periodontal therapy | Intervention Type: PROCEDURE; Name: Oral hygiene instructions; Assigned to Arm(s): Nonsurgical periodontal therapy, Oral hygiene instructions
B: Arm Label: treatment; Type: EXPERIMENTAL; Interventions: Procedure: non-surgical periodontal treatment | Arm Label: control; Type: OTHER; Interventions: Procedure: non-surgical periodontal treatment | Intervention Type: PROCEDURE; Name: non-surgical periodontal treatment; Assigned to Arm(s): control, treatment
C: Arm Label: Non-surgical periodontal therapy; Type: EXPERIMENTAL; Interventions: Procedure: Non-surgical periodontal therapy | Arm Label: Delayed non-surgical periodontal therapy; Type: OTHER; Interventions: Other: Delayed non-surgical periodontal therapy | Intervention Type: PROCEDURE; Name: Non-surgical periodontal therapy; Assigned to Arm(s): Non-surgical periodontal therapy | Intervention Type: OTHER; Name: Delayed non-surgical periodontal therapy; Assigned to Arm(s): Delayed non-surgical periodontal therapy
D: Arm Label: intervention; Type: EXPERIMENTAL; Interventions: Procedure: Periodontal Scaling and root planing | Intervention Type: PROCEDURE; Name: Periodontal Scaling and root planing; Assigned to Arm(s): intervention

Answer: D