Please select the outcome measures that correspond to the clinical trial below.
Title: Effects of Antioxidants Supplementation on Muscular Function of Patients Affected by Facioscapulohumeral Dystrophy (FSHD)
Brief Summary: On the basis of published data and the investigators' results indicating that oxidative stress may contribute to the peripheral skeletal muscle dysfunction in patients with FSHD, the investigators propose a study to test whether or not an antioxidant supplementation has a therapeutic interest for patients with FSHD. Their results have important implications for the successful implementation of rational antioxidant therapy in FSHD in which cell loss could be linked to oxidative stress.


Options:
A: Change in reduced glutathione in blood (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in reduced glutathione in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise); Change in protein carbonyls in red blood cells and serum (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in protein carbonyls in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise); Change in thiobarbituric acid reactive substances in red blood cells and serum (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in thiobarbituric acid reactive substances in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise); Change in oxidized glutathione in red blood cells and blood (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in total antioxidant capacity in serum (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in oxidized glutathione in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise); Change in catalase activity in red blood cells and serum (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in glutathione peroxidase activity in red blood cells (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in creatine kinase activity in plasma (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in C-reactive protein in plasma (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in macrophage infiltration in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise); Change in white blood cell count in blood (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in neutrophil count in blood (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in fatty acid binding protein in plasma (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in cortisol concentration in blood (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in testosterone concentration in plasma (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in cytokine concentration in plasma (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in adhesion molecule concentration in blood (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in intracellular signalling proteins in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise); Change in myogenic determination factor (MyoD) protein levels in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise); Change in tumor necrosis factor α in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise)
B: Change in physical performance from using Placebo to using Pomegranate juice (3min after Placebo and Pomegranate training sessions); Change in Acute Hematological responses from using Placebo to using Pomegranate juice (3min after Placebo and Pomegranate training sessions); Change in Acute Biochemical responses from using Placebo to using Pomegranate juice (3min after Placebo and Pomegranate training sessions); Change in Delayed Hematological responses from using Placebo to using Pomegranate juice (48h after Placebo and Pomegranate training sessions); Change in Delayed Biochemical responses from using Placebo to using Pomegranate juice (48h after Placebo and Pomegranate training sessions)
C: PGC-1alpha mRNA expression in skeletal muscle PPARgamma mRNA expression in skeletal muscle Serum malondialdehyde concentration (after 4 weeks)
D: Improvement of muscle effort tolerance after antioxidant supplementation (duration study 3 years)

Answer: D