Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Folic Acid and Zinc Supplementation Trial: A Multi-center, Double-blind, Block-randomized, Placebo-controlled Trial
Brief Summary: The overarching goal of this trial is to determine if an intervention comprising folic acid and zinc dietary supplementation improves semen quality and indirectly fertility outcomes (i.e., live birth rate) among couples trying to conceive and seeking assisted reproduction. The following study objectives underlie successful attainment of the overarching research goal:

1. To estimate the effect of folic acid and zinc dietary supplementation on semen quality parameters, including but not limited to concentration, motility, morphology, and sperm DNA integrity, relative to the placebo group.
2. To estimate the effect of folic acid and zinc dietary supplementation on fertility treatment outcomes \[fertilization, embryo quality, implantation/human Chorionic Gonadotropin (hCG) confirmed pregnancy, clinical pregnancy, live birth\], relative to the placebo group.
3. To estimate the association between semen quality parameters, sperm DNA integrity and fertility treatment outcomes (fertilization, embryo quality, clinical pregnancy, live birth) and to identify the best combination of semen quality parameters for prediction of clinical pregnancy and live birth.
4. To estimate the effect of folic acid and zinc dietary supplementation on fertilization rates among couples undergoing assisted reproductive technology procedures, relative to the placebo group.
5. To estimate the effect of folic acid and zinc dietary supplementation on embryonic quality among couples undergoing assisted reproductive technology procedures, relative to the placebo group.


Options:
A: Arm Label: Impryl; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Impryl | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: Impryl; Assigned to Arm(s): Impryl | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo
B: Arm Label: Folic acid and zinc supplementation; Type: EXPERIMENTAL; Interventions: Dietary Supplement: 5 mg folic acid and 30 mg elemental zinc | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo Comparator: Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: 5 mg folic acid and 30 mg elemental zinc; Assigned to Arm(s): Folic acid and zinc supplementation | Intervention Type: DRUG; Name: Placebo Comparator: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: Resveratrol; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Resveratrol | Arm Label: Control; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo pills | Intervention Type: DIETARY_SUPPLEMENT; Name: Resveratrol; Assigned to Arm(s): Resveratrol | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo pills; Assigned to Arm(s): Control
D: Arm Label: DHA plus vitamin E; Type: EXPERIMENTAL; Interventions: Dietary Supplement: vitamin E, Dietary Supplement: DHA | Arm Label: VitaminE plus placebo; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: vitamin E, Other: placebo | Arm Label: placebo plus placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Arm Label: DHA plus placebo; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: DHA, Other: placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: vitamin E; Assigned to Arm(s): DHA plus vitamin E, VitaminE plus placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: DHA; Assigned to Arm(s): DHA plus placebo, DHA plus vitamin E | Intervention Type: OTHER; Name: placebo; Assigned to Arm(s): DHA plus placebo, VitaminE plus placebo, placebo plus placebo

Answer: B