Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Double-blind, Placebo and Active-controlled, Parallel-group Study to Evaluate the Analgesic Efficacy and Safety of Dexketoprofen Trometamol and Tramadol Hydrochloride Oral Fixed Combination on Moderate to Severe Acute Pain After Elective Unilateral Total Hip Arthroplasty
Brief Summary: This study aims to evaluate the analgesic efficacy of single and repeated doses of fixed combination of dexketoprofen trometamol (DKP) and tramadol hydrochloride (TRAM) in comparison to the single agents (and placebo for the single dose phase only) Approximately 600 male and female patients presenting moderate to severe pain after an elective primary hip arthroplasty are eligible to be randomised provided that they experience moderate to severe pain on the day after surgery.


Options:
A: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: Ibuprofen; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ibuprofen | Arm Label: TRAM.HCl high dose; Type: ACTIVE_COMPARATOR; Interventions: Drug: Tramadol Hydrochloride | Arm Label: TRAM.HCl low dose; Type: ACTIVE_COMPARATOR; Interventions: Drug: Tramadol Hydrochloride | Arm Label: DKP-TRIS high dose; Type: ACTIVE_COMPARATOR; Interventions: Drug: Dexketoprofen Trometamol | Arm Label: DKP-TRIS low dose; Type: ACTIVE_COMPARATOR; Interventions: Drug: Dexketoprofen Trometamol | Arm Label: DKP-TRIS low dose - TRAM.HCl low dose; Type: EXPERIMENTAL; Interventions: Drug: Dexketoprofen Trometamol + Tramadol Hydrochloride | Arm Label: DKP-TRIS low dose - TRAM.HCl high dose; Type: EXPERIMENTAL; Interventions: Drug: Dexketoprofen Trometamol + Tramadol Hydrochloride | Arm Label: DKP-TRIS high dose - TRAM.HCl low dose; Type: EXPERIMENTAL; Interventions: Drug: Dexketoprofen Trometamol + Tramadol Hydrochloride | Arm Label: DKP-TRIS high dose - TRAM.HCl high dose; Type: EXPERIMENTAL; Interventions: Drug: Dexketoprofen Trometamol + Tramadol Hydrochloride | Intervention Type: DRUG; Name: Dexketoprofen Trometamol; Assigned to Arm(s): DKP-TRIS low dose | Intervention Type: DRUG; Name: Dexketoprofen Trometamol; Assigned to Arm(s): DKP-TRIS high dose | Intervention Type: DRUG; Name: Tramadol Hydrochloride; Assigned to Arm(s): TRAM.HCl low dose | Intervention Type: DRUG; Name: Tramadol Hydrochloride; Assigned to Arm(s): TRAM.HCl high dose | Intervention Type: DRUG; Name: Ibuprofen; Assigned to Arm(s): Ibuprofen | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: Dexketoprofen Trometamol + Tramadol Hydrochloride; Assigned to Arm(s): DKP-TRIS low dose - TRAM.HCl low dose | Intervention Type: DRUG; Name: Dexketoprofen Trometamol + Tramadol Hydrochloride; Assigned to Arm(s): DKP-TRIS low dose - TRAM.HCl high dose | Intervention Type: DRUG; Name: Dexketoprofen Trometamol + Tramadol Hydrochloride; Assigned to Arm(s): DKP-TRIS high dose - TRAM.HCl low dose | Intervention Type: DRUG; Name: Dexketoprofen Trometamol + Tramadol Hydrochloride; Assigned to Arm(s): DKP-TRIS high dose - TRAM.HCl high dose
B: Arm Label: DKP/TRAM followed by DKP/TRAM; Type: EXPERIMENTAL; Interventions: Drug: Dexketoprofen/Tramadol-single dose, Drug: Dexketoprofen/Tramadol-multiple doses | Arm Label: DKP followed by DKP; Type: ACTIVE_COMPARATOR; Interventions: Drug: Dexketoprofen-single dose, Drug: Dexketoprofen-multiple doses | Arm Label: TRAM followed by TRAM; Type: ACTIVE_COMPARATOR; Interventions: Drug: Tramadol-single dose, Drug: Tramadol-multiple doses | Arm Label: Placebo followed by DKP/TRAM; Type: OTHER; Interventions: Drug: Placebo, Drug: Dexketoprofen/Tramadol-multiple doses | Arm Label: Placebo followed by DKP; Type: OTHER; Interventions: Drug: Placebo, Drug: Dexketoprofen-multiple doses | Arm Label: Placebo followed by TRAM; Type: OTHER; Interventions: Drug: Placebo, Drug: Tramadol-multiple doses | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo followed by DKP, Placebo followed by DKP/TRAM, Placebo followed by TRAM | Intervention Type: DRUG; Name: Dexketoprofen-single dose; Assigned to Arm(s): DKP followed by DKP | Intervention Type: DRUG; Name: Tramadol-single dose; Assigned to Arm(s): TRAM followed by TRAM | Intervention Type: DRUG; Name: Dexketoprofen/Tramadol-single dose; Assigned to Arm(s): DKP/TRAM followed by DKP/TRAM | Intervention Type: DRUG; Name: Dexketoprofen-multiple doses; Assigned to Arm(s): DKP followed by DKP, Placebo followed by DKP | Intervention Type: DRUG; Name: Tramadol-multiple doses; Assigned to Arm(s): Placebo followed by TRAM, TRAM followed by TRAM | Intervention Type: DRUG; Name: Dexketoprofen/Tramadol-multiple doses; Assigned to Arm(s): DKP/TRAM followed by DKP/TRAM, Placebo followed by DKP/TRAM
C: Arm Label: DKP/TRAM followed by DKP/TRAM; Type: EXPERIMENTAL; Interventions: Drug: Dexketoprofen/Tramadol-single dose, Drug: Dexketoprofen/Tramadol-multiple doses | Arm Label: DKP followed by DKP; Type: ACTIVE_COMPARATOR; Interventions: Drug: Dexketoprofen-single dose, Drug: Dexketoprofen-multiple doses | Arm Label: TRAM followed by TRAM; Type: ACTIVE_COMPARATOR; Interventions: Drug: Tramadol-single dose, Drug: Tramadol-multiple doses | Arm Label: Placebo followed by DKP/TRAM; Type: OTHER; Interventions: Drug: Placebo, Drug: Dexketoprofen/Tramadol-multiple doses | Arm Label: Placebo followed by DKP; Type: OTHER; Interventions: Drug: Placebo, Drug: Dexketoprofen-multiple doses | Arm Label: Placebo followed by TRAM; Type: OTHER; Interventions: Drug: Placebo, Drug: Tramadol-multiple doses | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo followed by DKP, Placebo followed by DKP/TRAM, Placebo followed by TRAM | Intervention Type: DRUG; Name: Tramadol-single dose; Assigned to Arm(s): TRAM followed by TRAM | Intervention Type: DRUG; Name: Dexketoprofen-single dose; Assigned to Arm(s): DKP followed by DKP | Intervention Type: DRUG; Name: Dexketoprofen/Tramadol-single dose; Assigned to Arm(s): DKP/TRAM followed by DKP/TRAM | Intervention Type: DRUG; Name: Tramadol-multiple doses; Assigned to Arm(s): Placebo followed by TRAM, TRAM followed by TRAM | Intervention Type: DRUG; Name: Dexketoprofen-multiple doses; Assigned to Arm(s): DKP followed by DKP, Placebo followed by DKP | Intervention Type: DRUG; Name: Dexketoprofen/Tramadol-multiple doses; Assigned to Arm(s): DKP/TRAM followed by DKP/TRAM, Placebo followed by DKP/TRAM
D: Arm Label: Dexketoprofen trometamol; Type: EXPERIMENTAL; Interventions: Drug: Dexketoprofen trometamol | Arm Label: Preoperative control; Type: PLACEBO_COMPARATOR; Interventions: Drug: Preoperative control | Intervention Type: DRUG; Name: Dexketoprofen trometamol; Assigned to Arm(s): Dexketoprofen trometamol | Intervention Type: DRUG; Name: Preoperative control; Assigned to Arm(s): Preoperative control

Answer: C