Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Phase III Randomised, Double Blind, Placebo Controlled Study of Olaparib Maintenance Monotherapy in Platinum Sensitive Relapsed BRCA Mutated Ovarian Cancer Patients With a Complete or Partial Response Following Platinum Based Chemotherapy
Brief Summary: A Phase III, randomised, double-blind, placebo-controlled, multi-centre study to assess the efficacy of olaparib maintenance monotherapy in relapsed high grade serous ovarian cancer (HGSOC) patients (including patients with primary peritoneal and / or fallopian tube cancer) or high grade endometrioid cancer with BRCA mutations (documented mutation in BRCA1 or BRCA2 that is predicted to be deleterious or suspected deleterious (known or predicted to be detrimental/lead to loss of function)) who have responded following platinum based chemotherapy.


Options:
A: Arm Label: Pembrolizumab + paclitaxel ± bevacizumab; Type: EXPERIMENTAL; Interventions: Biological: Pembrolizumab, Drug: Paclitaxel, Drug: Bevacizumab, Drug: Docetaxel | Arm Label: Placebo + paclitaxel ± bevacizumab; Type: PLACEBO_COMPARATOR; Interventions: Drug: Paclitaxel, Drug: Bevacizumab, Other: Placebo for pembrolizumab, Drug: Docetaxel | Intervention Type: BIOLOGICAL; Name: Pembrolizumab; Assigned to Arm(s): Pembrolizumab + paclitaxel ± bevacizumab | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): Pembrolizumab + paclitaxel ± bevacizumab, Placebo + paclitaxel ± bevacizumab | Intervention Type: DRUG; Name: Bevacizumab; Assigned to Arm(s): Pembrolizumab + paclitaxel ± bevacizumab, Placebo + paclitaxel ± bevacizumab | Intervention Type: OTHER; Name: Placebo for pembrolizumab; Assigned to Arm(s): Placebo + paclitaxel ± bevacizumab | Intervention Type: DRUG; Name: Docetaxel; Assigned to Arm(s): Pembrolizumab + paclitaxel ± bevacizumab, Placebo + paclitaxel ± bevacizumab
B: Arm Label: Olaparib 300mg tablets; Type: EXPERIMENTAL; Interventions: Drug: Olaparib 300mg tablets | Arm Label: Placebo tablets; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo to match olaparib 300mg | Intervention Type: DRUG; Name: Olaparib 300mg tablets; Assigned to Arm(s): Olaparib 300mg tablets | Intervention Type: DRUG; Name: Placebo to match olaparib 300mg; Assigned to Arm(s): Placebo tablets
C: Arm Label: Arm I (cediranib maleate and olaparib); Type: EXPERIMENTAL; Interventions: Procedure: Biopsy Procedure, Procedure: Biospecimen Collection, Drug: Cediranib Maleate, Procedure: Computed Tomography, Procedure: Echocardiography Test, Procedure: Magnetic Resonance Imaging, Procedure: Multigated Acquisition Scan, Drug: Olaparib | Arm Label: Arm II (olaparib); Type: ACTIVE_COMPARATOR; Interventions: Procedure: Biopsy Procedure, Procedure: Biospecimen Collection, Procedure: Computed Tomography, Procedure: Echocardiography Test, Procedure: Magnetic Resonance Imaging, Procedure: Multigated Acquisition Scan, Drug: Olaparib | Intervention Type: PROCEDURE; Name: Biopsy Procedure; Assigned to Arm(s): Arm I (cediranib maleate and olaparib), Arm II (olaparib) | Intervention Type: PROCEDURE; Name: Biospecimen Collection; Assigned to Arm(s): Arm I (cediranib maleate and olaparib), Arm II (olaparib) | Intervention Type: DRUG; Name: Cediranib Maleate; Assigned to Arm(s): Arm I (cediranib maleate and olaparib) | Intervention Type: PROCEDURE; Name: Computed Tomography; Assigned to Arm(s): Arm I (cediranib maleate and olaparib), Arm II (olaparib) | Intervention Type: PROCEDURE; Name: Echocardiography Test; Assigned to Arm(s): Arm I (cediranib maleate and olaparib), Arm II (olaparib) | Intervention Type: PROCEDURE; Name: Magnetic Resonance Imaging; Assigned to Arm(s): Arm I (cediranib maleate and olaparib), Arm II (olaparib) | Intervention Type: PROCEDURE; Name: Multigated Acquisition Scan; Assigned to Arm(s): Arm I (cediranib maleate and olaparib), Arm II (olaparib) | Intervention Type: DRUG; Name: Olaparib; Assigned to Arm(s): Arm I (cediranib maleate and olaparib), Arm II (olaparib)
D: Arm Label: BIBF1120; Type: EXPERIMENTAL; Interventions: Drug: BIBF1120 | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: BIBF1120; Assigned to Arm(s): BIBF1120 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo

Answer: B