Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized Three-Arm, Multicenter Comparison of 1 Year and 2 Years of Herceptin Versus No Herceptin in Women With HER2-Positive Primary Breast Cancer Who Have Completed Adjuvant Chemotherapy
Brief Summary: The purpose of this trial is to evaluate Herceptin treatment for 1 year and 2 years (versus observation/no Herceptin) in women with HER2-overexpressing primary breast cancer who have completed (neo-)adjuvant systemic chemotherapy, definitive surgery, and radiotherapy, if applicable. Efficacy and safety will be assessed for 10 years from randomization for each participant. All participants will continue to be followed for survival until 10 years after enrollment of the last participant.


Options:
A: Intervention Type: BIOLOGICAL; Name: trastuzumab; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: capecitabine; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: docetaxel; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: epirubicin hydrochloride; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: adjuvant therapy; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: neoadjuvant therapy; Assigned to Arm(s): N/A
B: Arm Label: Observation Arm; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Herceptin 1-Year Arm; Type: EXPERIMENTAL; Interventions: Drug: Herceptin | Arm Label: Herceptin 2-Year Arm; Type: EXPERIMENTAL; Interventions: Drug: Herceptin | Intervention Type: DRUG; Name: Herceptin; Assigned to Arm(s): Herceptin 1-Year Arm | Intervention Type: DRUG; Name: Herceptin; Assigned to Arm(s): Herceptin 2-Year Arm
C: Arm Label: Doxorubicin+Cyclophosphamide (AC) followed by Docetaxel (AC→T); Type: EXPERIMENTAL; Interventions: Drug: Doxorubicin, Drug: Cyclophosphamide, Drug: Docetaxel | Arm Label: AC followed by Docetaxel + Herceptin (AC→TH); Type: EXPERIMENTAL; Interventions: Drug: Doxorubicin, Drug: Cyclophosphamide, Drug: Docetaxel, Drug: Herceptin | Arm Label: Docetaxel + Carboplatin + Herceptin (TCH); Type: EXPERIMENTAL; Interventions: Drug: Docetaxel, Drug: Herceptin, Drug: Carboplatin | Intervention Type: DRUG; Name: Doxorubicin; Assigned to Arm(s): AC followed by Docetaxel + Herceptin (AC→TH), Doxorubicin+Cyclophosphamide (AC) followed by Docetaxel (AC→T) | Intervention Type: DRUG; Name: Cyclophosphamide; Assigned to Arm(s): AC followed by Docetaxel + Herceptin (AC→TH), Doxorubicin+Cyclophosphamide (AC) followed by Docetaxel (AC→T) | Intervention Type: DRUG; Name: Docetaxel; Assigned to Arm(s): AC followed by Docetaxel + Herceptin (AC→TH), Docetaxel + Carboplatin + Herceptin (TCH), Doxorubicin+Cyclophosphamide (AC) followed by Docetaxel (AC→T) | Intervention Type: DRUG; Name: Herceptin; Assigned to Arm(s): AC followed by Docetaxel + Herceptin (AC→TH), Docetaxel + Carboplatin + Herceptin (TCH) | Intervention Type: DRUG; Name: Carboplatin; Assigned to Arm(s): Docetaxel + Carboplatin + Herceptin (TCH)
D: Intervention Type: BIOLOGICAL; Name: trastuzumab; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: aromatase inhibition therapy; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: docetaxel; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: epirubicin hydrochloride; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: fluorouracil; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: paclitaxel; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: releasing hormone agonist therapy; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: tamoxifen citrate; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: adjuvant therapy; Assigned to Arm(s): N/A | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): N/A

Answer: B