Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Skin Disinfection With Octenidine Dihydrochloride for the Prevention of Catheter-Associated Infections - A Double-Blind, Randomized, Controlled Trial
Brief Summary: Health-care-acquired infections are of tremendous importance for patients, especially catheter-associated infections. More than 40% of all bloodstream infections are associated with central venous catheters (CVC; catheters which are inserted into a large vein near the heart). Of all patients that acquire such an infection 1% to 5% die as a result from it. The insertion site is the main source of contamination and infection. In general, bacteria of the skin are the cause of infection, especially in short-term CVCs (10-14 days). Therefore it is necessary to efficiently disinfect the skin for the preparation and care of CVC insertion sites. Several substances are used for disinfection. Alcohol-based disinfectants are mainly used in Central Europe, other preparations contain povidine-iodine or chlorhexidine. Alcoholic disinfectants have a rapid initial effect, chlorhexidine shows an additional remanent (longer lasting) effect. A further substance, octenidine dihydrochloride, also demonstrated a remanent effect in a pilot study with neurosurgical patients. The purpose of our study is to compare an alcohol-based disinfectant containing octenidine dihydrochloride with a pure alcoholic disinfectant regarding efficacy and tolerability in patients receiving a CVC for a minimum of 5 days.


Options:
A: Arm Label: Oct/Alc; Type: ACTIVE_COMPARATOR; Interventions: Drug: 0.1% Octenidine with 30% 1-propanol and 45% 2-propanol | Arm Label: Alc; Type: ACTIVE_COMPARATOR; Interventions: Drug: 74% Ethanol with 10% 2-propanol | Intervention Type: DRUG; Name: 0.1% Octenidine with 30% 1-propanol and 45% 2-propanol; Assigned to Arm(s): Oct/Alc | Intervention Type: DRUG; Name: 74% Ethanol with 10% 2-propanol; Assigned to Arm(s): Alc
B: Arm Label: PVI paint; Type: ACTIVE_COMPARATOR; Interventions: Procedure: skin disinfection prior catheter insertion | Arm Label: PVI scrub and paint; Type: ACTIVE_COMPARATOR; Interventions: Procedure: skin disinfection prior catheter insertion | Arm Label: Chlorhexidine paint; Type: ACTIVE_COMPARATOR; Interventions: Procedure: skin disinfection prior catheter insertion | Arm Label: chlorhexidine scrub and paint; Type: ACTIVE_COMPARATOR; Interventions: Procedure: skin disinfection prior catheter insertion | Intervention Type: PROCEDURE; Name: skin disinfection prior catheter insertion; Assigned to Arm(s): Chlorhexidine paint, PVI paint, PVI scrub and paint, chlorhexidine scrub and paint
C: Arm Label: 3-days dressing frequency/CHX sponge; Type: EXPERIMENTAL; Interventions: Device: Chlorhexidine Sponge (Biopatch TM) | Arm Label: 7-days dressing frequency/CHX sponge; Type: EXPERIMENTAL; Interventions: Device: Chlorhexidine Sponge (Biopatch TM), Behavioral: 7-day catheter dressing frequency | Arm Label: 3-days dressing frequency/No CHX sponge; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: 7-days dressing change/No CHX sponge; Type: EXPERIMENTAL; Interventions: Behavioral: 7-day catheter dressing frequency | Intervention Type: DEVICE; Name: Chlorhexidine Sponge (Biopatch TM); Assigned to Arm(s): 3-days dressing frequency/CHX sponge, 7-days dressing frequency/CHX sponge | Intervention Type: BEHAVIORAL; Name: 7-day catheter dressing frequency; Assigned to Arm(s): 7-days dressing change/No CHX sponge, 7-days dressing frequency/CHX sponge
D: Intervention Type: DRUG; Name: Skin disinfection; Assigned to Arm(s): N/A

Answer: A