Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Multicenter, Randomized, Single-blind, Placebo-controlled, Combined 2-fold Cross-over and Group-comparison, Dose-escalation Study to Investigate Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Single Oral Doses of BAY 85-3934 in Subjects With Chronic Kidney Disease (CKD)
Brief Summary: Primary objective was to assess in subjects with CKD: Safety and tolerability of molidustat (BAY 85-3934), effects of molidustat on non-invasive hemodynamics Secondary objectives were to assess: Effects on pharmacodynamic parameters of erythropoiesis (erythropoietin, reticulocytes, erythrocytes, hemoglobin, hematocrit), pharmacokinetics of molidustat, exploratory biomarkers, ie, midregional pro-atrial natriuretic peptide, midregional pro-adrenomedullin, plasma renin activity, and optionally B-type natriuretic peptide, vascular endothelial growth factor, cyclic guanosine monophosphate, cyclic adenosine monophosphate, and noradrenaline


Options:
A: Arm Label: Daprodustat; Type: EXPERIMENTAL; Interventions: Drug: Daprodustat small, Drug: Daprodustat large, Drug: Darbepoetin alfa placebo | Arm Label: Darbepoetin alfa; Type: ACTIVE_COMPARATOR; Interventions: Drug: Daprodustat small placebo, Drug: Daprodustat large placebo, Drug: Darbepoetin alfa | Intervention Type: DRUG; Name: Daprodustat small; Assigned to Arm(s): Daprodustat | Intervention Type: DRUG; Name: Daprodustat small placebo; Assigned to Arm(s): Darbepoetin alfa | Intervention Type: DRUG; Name: Daprodustat large; Assigned to Arm(s): Daprodustat | Intervention Type: DRUG; Name: Daprodustat large placebo; Assigned to Arm(s): Darbepoetin alfa | Intervention Type: DRUG; Name: Darbepoetin alfa; Assigned to Arm(s): Darbepoetin alfa | Intervention Type: DRUG; Name: Darbepoetin alfa placebo; Assigned to Arm(s): Daprodustat
B: Arm Label: Vadadustat, Dose 1; Type: EXPERIMENTAL; Interventions: Drug: Vadadustat | Arm Label: Vadadustat, Dose 2; Type: EXPERIMENTAL; Interventions: Drug: Vadadustat | Arm Label: Vadadustat, Dose 3; Type: EXPERIMENTAL; Interventions: Drug: Vadadustat | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Vadadustat; Assigned to Arm(s): Vadadustat, Dose 1, Vadadustat, Dose 2, Vadadustat, Dose 3 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: Arm A + E (Participants on HD): Roxadustat Only, No Iron; Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Arm B (Participants on HD): PO Iron (Ferrous Fumarate or Ferrous Gluconate) Between 50 and 195 mg; Type: EXPERIMENTAL; Interventions: Drug: Roxadustat, Drug: Oral Iron | Arm Label: Arm C (Participants on HD): IV Iron (Ferric Gluconate Complex in Sucrose or Equivalent) 60 mg; Type: EXPERIMENTAL; Interventions: Drug: Roxadustat, Drug: IV Iron | Arm Label: Arm D (Participants on PD): PO Iron (Ferrous Fumarate or Ferrous Gluconate) Between 50 and 195 mg; Type: EXPERIMENTAL; Interventions: Drug: Roxadustat, Drug: Oral Iron | Intervention Type: DRUG; Name: Roxadustat; Assigned to Arm(s): Arm A + E (Participants on HD): Roxadustat Only, No Iron, Arm B (Participants on HD): PO Iron (Ferrous Fumarate or Ferrous Gluconate) Between 50 and 195 mg, Arm C (Participants on HD): IV Iron (Ferric Gluconate Complex in Sucrose or Equivalent) 60 mg, Arm D (Participants on PD): PO Iron (Ferrous Fumarate or Ferrous Gluconate) Between 50 and 195 mg | Intervention Type: DRUG; Name: Oral Iron; Assigned to Arm(s): Arm B (Participants on HD): PO Iron (Ferrous Fumarate or Ferrous Gluconate) Between 50 and 195 mg, Arm D (Participants on PD): PO Iron (Ferrous Fumarate or Ferrous Gluconate) Between 50 and 195 mg | Intervention Type: DRUG; Name: IV Iron; Assigned to Arm(s): Arm C (Participants on HD): IV Iron (Ferric Gluconate Complex in Sucrose or Equivalent) 60 mg
D: Arm Label: Molidustat, 80 mg; Type: EXPERIMENTAL; Interventions: Drug: Molidustat (BAY85-3934), Drug: Placebo | Arm Label: Molidustat, 120 mg; Type: EXPERIMENTAL; Interventions: Drug: Molidustat (BAY85-3934), Drug: Placebo | Arm Label: Molidustat, 40 mg; Type: EXPERIMENTAL; Interventions: Drug: Molidustat (BAY85-3934), Drug: Placebo | Arm Label: Molidustat, 160 mg; Type: EXPERIMENTAL; Interventions: Drug: Molidustat (BAY85-3934), Drug: Placebo | Intervention Type: DRUG; Name: Molidustat (BAY85-3934); Assigned to Arm(s): Molidustat, 120 mg, Molidustat, 160 mg, Molidustat, 40 mg, Molidustat, 80 mg | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Molidustat, 120 mg, Molidustat, 160 mg, Molidustat, 40 mg, Molidustat, 80 mg

Answer: D