Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Efficacy and Safety of Granulocyte-colony Stimulating Factor in Patients With Severe Alcoholic Hepatitis With Null or Partial Response to Steroid: A Randomized, Double-blind, Placebo-controlled, Nationwide Multi-center Study
Brief Summary: Steroid is the treatment of choice in patients with severe alcoholic hepatitis. However, null- or partial responder of steroid treatment is recommended to consider liver transplantation. The yearly demand for liver transplants far exceeds the supply of available organs and alcoholic liver disease has been a controversial indication for transplantation. Granulocyte-Colony Stimulating Factor (G-CSF) has been reported to have effect of proliferation of hepatic progenitors in alcoholic steatohepatitis. The aim of this study is to investigate the efficacy of G-CSF in patients with severe alcoholic hepatitis with null or partial response to steroid.


Options:
A: Arm Label: G-CSF + steroid in partial responder; Type: EXPERIMENTAL; Interventions: Drug: G-CSF (Filgrastim injection), Drug: steroid | Arm Label: Placebo + steroid in partial responder; Type: PLACEBO_COMPARATOR; Interventions: Drug: steroid, Drug: placebo | Arm Label: G-CSF in null responder to steroid; Type: EXPERIMENTAL; Interventions: Drug: G-CSF (Filgrastim injection) | Arm Label: Placebo in null responder to steroid; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo | Intervention Type: DRUG; Name: G-CSF (Filgrastim injection); Assigned to Arm(s): G-CSF + steroid in partial responder, G-CSF in null responder to steroid | Intervention Type: DRUG; Name: steroid; Assigned to Arm(s): G-CSF + steroid in partial responder, Placebo + steroid in partial responder | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Placebo + steroid in partial responder, Placebo in null responder to steroid
B: Arm Label: Granulocyte colony-stimulating factor; Type: EXPERIMENTAL; Interventions: Drug: Granulocyte colony-stimulating factor, Drug: standard treatment | Arm Label: standard treatment; Type: ACTIVE_COMPARATOR; Interventions: Drug: standard treatment | Intervention Type: DRUG; Name: Granulocyte colony-stimulating factor; Assigned to Arm(s): Granulocyte colony-stimulating factor | Intervention Type: DRUG; Name: standard treatment; Assigned to Arm(s): Granulocyte colony-stimulating factor, standard treatment
C: Arm Label: G-CSF + Erythropoietin; Type: EXPERIMENTAL; Interventions: Drug: G-CSF | Arm Label: G-CSF; Type: ACTIVE_COMPARATOR; Interventions: Drug: G-CSF+Erythropoetin | Intervention Type: DRUG; Name: G-CSF+Erythropoetin; Assigned to Arm(s): G-CSF | Intervention Type: DRUG; Name: G-CSF; Assigned to Arm(s): G-CSF + Erythropoietin
D: Arm Label: prednisolone or pentoxifylline + pegfiltrastim; Type: EXPERIMENTAL; Interventions: Drug: Standard of care + pegfiltrastim | Arm Label: prednisolone or pentoxifylline; Type: ACTIVE_COMPARATOR; Interventions: Drug: Standard of care | Intervention Type: DRUG; Name: Standard of care + pegfiltrastim; Assigned to Arm(s): prednisolone or pentoxifylline + pegfiltrastim | Intervention Type: DRUG; Name: Standard of care; Assigned to Arm(s): prednisolone or pentoxifylline

Answer: A