Please select the eligibility criteria that correspond to the clinical trial below.
Title: Multidimensional Intervention in Early Osteoarthritis (The Knee Study)
Brief Summary: Osteoarthritis (OA) is the most common joint-related disease and most prevalent form of arthritis in the United States. Pain relievers and anti-inflammatory medications are the most commonly prescribed treatments for OA. These medications, however, cannot completely alleviate OA symptoms. Additional recommended strategies for managing OA include physical and occupational therapy, exercise, and patient education. This study will compare the effectiveness of a physical training program, a self-management training program, and a program including both physical and self-management training for improving physical function in people with early stage knee OA.


Options:
A: Inclusion Criteria:

* arthritic condition (osteoarthritis, rheumatoid arthritis or fibromyalgia)
* internet access and ability to use computer

Exclusion Criteria:

* active treatment for cancer
* taken small group arthritis self-management program
B: Inclusion Criteria:

* Radiographic evidence of hip or knee osteoarthritis
* Current / persistent joint symptoms (pain, aching, stiffness)

Exclusion Criteria:

* Other rheumatic disease (i.e., rheumatoid arthritis, fibromyalgia)
* Hospitalization for stroke or cardiovascular event within past 3 months
* Metastatic cancer
* Active diagnosis of psychosis
* Terminal illness
* On waiting list for arthroplasty
* Resident of nursing home
* Severely impaired in hearing or speech (participants must be able to respond to phone calls)
* Significant cognitive dysfunction
* No access to a telephone
* Current participation in another interventional study for osteoarthritis
C: Inclusion criteria:

* History of pain on most days (i.e., 4 or more days in a week) in one or both knees for at least 4 months during the year prior to study entry
* Duration of symptoms (defined as pain on most days for at least 4 months in 1 year) of less than 5 years
* Radiographic evidence of grade II knee OA
* Some level of disability, represented as a score of 3 or higher for at least three of the following WOMAC Index items: descending or ascending stairs; walking; bending; and performing daily activities

Exclusion criteria:

* Any uncontrolled medical condition that could prevent safe participation in the study (e.g., uncontrolled heart disease, blood pressure, or respiratory conditions)
* Any neurological condition that could affect coordination
* Inflammatory arthritis (e.g., rheumatoid or psoriatic arthritis)
* Participates in aerobic activity or resistance training for more than 60 minutes per week
* History of knee surgery
* Radiographic grade I, III-IV (Kellgren and Lawrence classification)
* Body mass index of at most 37.5 Kg/m2 (Individuals over this limit will be advised to follow a weight loss program and achieve stable weight for 6 months prior to participation.)
* History of a knee corticosteroid injection in the 3 months prior to study entry
* Plans to move from the local area
* Plans to become pregnant during the study
D: Inclusion Criteria:

* Radiographic evidence of hip OA and/or radiographic evidence of or meets clinical criteria for knee OA
* Current joint (hip and/or knee) symptoms
* BMI \>= 25
* Physically inactive

Exclusion Criteria:

* Diagnosis of rheumatoid arthritis, fibromyalgia, or other systemic rheumatic disease
* Diagnosis of a motor neuron disease, Parkinson's disease, multiple sclerosis, or Paget's disease
* Diagnosis of metastatic cancer
* Hospitalized for a stroke, myocardial infarction or coronary artery revascularization in the past 3 months
* On waiting list for or planning arthroplasty
* Total joint replacement (hip or knee) surgery, other hip or knee surgery, meniscus tear (verified by MRI), or ACL tear in the past 6 months
* History of gout in hip or knee
* Quadriplegia or paraplegia
* Active diagnosis of psychosis or serious personality disorder
* Diagnosis of dementia or other memory loss condition
* Current, uncontrolled substance abuse disorder
* Severly impaired speech or hearing (patients must be able to respond to phone calls)
* No access to a telephone
* Inability to understand and speak English
* Blindness
* Resident in nursing home
* Serious / terminal illness as indicated by referral to hospice or palliative care
* For females: currently pregnant or planning to become pregnant
* No visit to their Duke primary health care provider in the last 18 months
* Participating in another OA intervention of other lifestyle change study
* Other self-reported medical problem that would prohibit participation in the study
* Other health condition or personal issue judged by a study team member or primary care physician to make the patient inappropriate for study participation

Answer: C