Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Effects of Preimplantation Genetic Screening 2.0 on the Clinical Outcomes of Assisted Reproductive Treatment in Patients With Recurrent Pregnancy Loss : A Multi-center-based Prospective Randomized Clinical Trial
Brief Summary: 50%-60% of the known causes of recurrent pregnancy loss(RPL) are associated with embryonic aneuploidy, such that preimplantation genetic screening (PGS) on embryos acquired by assisted reproductive treatment should improve the rate of pregnancy and live birth in those patients. In dispute though the clinical application of PGS has been, a series of studies show that the new generation of PGS(PGS 2.0), based on blastocyst biopsy followed by whole genome analysis, has significantly improved the clinical outcome of IVF treatment. At present, there is still a need for the evidence of the use of PGS 2.0 in RPL patients, who may benefit from this emerging technology considering the prevalence of genetic abnormalities and the number of transferable embryos in this population.

An earlier single center RCT conducted by our IVF center displayed higher implantation rate, clinical pregnancy rate and ongoing pregnancy rate calculated by per embryo transfer(ET) cycle in IVF/ICSI+PGS group compared with IVF/ICSI group.

This multi-center prospective randomized clinical trial is to provide more data to determine whether the clinical outcomes are significantly improved per treatment cycle such that provide evidence for the application of PGS in RPL patients. Besides, risk factors of PGS outcome are to be analyzed from multi-center data to build a model for prediction of the possible outcomes of PGS and direction of the clinical choice.


Options:
A: Arm Label: ICSI without PGS; Type: EXPERIMENTAL; Interventions: Procedure: ICSI without PGS | Arm Label: ICSI with PGS; Type: EXPERIMENTAL; Interventions: Procedure: ICSI with PGS | Intervention Type: PROCEDURE; Name: ICSI without PGS; Assigned to Arm(s): ICSI without PGS | Intervention Type: PROCEDURE; Name: ICSI with PGS; Assigned to Arm(s): ICSI with PGS
B: Arm Label: With PGS; Type: EXPERIMENTAL; Interventions: Procedure: IVF/ICSI, Genetic: PGS | Arm Label: Without PGS; Type: ACTIVE_COMPARATOR; Interventions: Procedure: IVF/ICSI, Other: Without PGS | Intervention Type: PROCEDURE; Name: IVF/ICSI; Assigned to Arm(s): With PGS, Without PGS | Intervention Type: GENETIC; Name: PGS; Assigned to Arm(s): With PGS | Intervention Type: OTHER; Name: Without PGS; Assigned to Arm(s): Without PGS
C: Arm Label: With PGS 2.0; Type: EXPERIMENTAL; Interventions: Procedure: IVF/ICSI, Genetic: PGS 2.0 | Arm Label: Without PGS 2.0; Type: ACTIVE_COMPARATOR; Interventions: Procedure: IVF/ICSI, Other: Conventional embryo morphology evaluation | Intervention Type: PROCEDURE; Name: IVF/ICSI; Assigned to Arm(s): With PGS 2.0, Without PGS 2.0 | Intervention Type: GENETIC; Name: PGS 2.0; Assigned to Arm(s): With PGS 2.0 | Intervention Type: OTHER; Name: Conventional embryo morphology evaluation; Assigned to Arm(s): Without PGS 2.0
D: Arm Label: Endometrial biopsy arm; Type: EXPERIMENTAL; Interventions: Procedure: Endometrial biopsy, Device: Transvaginal ultrasound | Arm Label: Control group; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: PROCEDURE; Name: Endometrial biopsy; Assigned to Arm(s): Endometrial biopsy arm | Intervention Type: DEVICE; Name: Transvaginal ultrasound; Assigned to Arm(s): Endometrial biopsy arm

Answer: C