Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Randomized Controlled Clinical Trial to Evaluate Safety and Effectiveness of CAF + Mucograft® Compared to CAF Alone in Patients With Gingival Recessions.
Brief Summary: The purpose of this multi-center study is to determine the efficacy and safety of Mucograft® in combination with the coronally advanced flap (CAF) for the treatment of gingival recessions. It is assumed that the CAF combined with Mucograft® will result in improved outcome in terms percentage of root coverage and soft tissue thickness in comparison to CAF alone (control).


Options:
A: Inclusion Criteria:

* Recession defects are Miller's class I or II and do not vary more or equal than 3 mm
* Main complaint aesthetic issues or dentine hypersensitivity
* The patient must be a candidate for bilateral root coverage procedure
* Patient shows sufficient plaque control (FMPS \< 20%)
* The patient is able to comply with the study-related procedures such as exercising good oral hygiene and attending all follow-up procedures
* The patient is able to fully understand the nature of the proposed surgery and is able to provide a signed informed consent

Exclusion Criteria:

* Smokers
* Systemic diseases
* Pregnants or lactating
* Periodontal disease
* General contraindications for dental and/or surgical treatment are present
* The patient has a history of malignancy, radiotherapy, or chemotherapy for malignancy within the past five years
* The patient is taking medications or having treatments which have an effect on mucosal healing in general (e.g. steroids, large doses of anti-inflammatory drugs)
B: Inclusion Criteria:

1. presenting Miller class I or II gingival recession in the maxillary canines or premolars;
2. visible cemento-enamel junction (CEJ) in the teeth included in the study and pulp vitality;
3. patients presenting no signs of active periodontal disease and full-mouth plaque and bleeding score ≤ 20%;
4. patients older than 18 years old;
5. probing depth ˂ 3 mm in the included teeth; 6) patients who agreed to participate and signed an informed consent form

Exclusion Criteria:

1. patients with systemic problems (cardiovascular, blood dyscrasias, immunodeficiency, and diabetes, among others) that will contraindicate the surgical procedure
2. patients taking medications known to interfere with the wound healing process or that contraindicate the surgical procedure
3. smokers or pregnant women
4. patients who underwent periodontal surgery in the area of interest; and 5) patients with orthodontic therapy in progress.
C: Inclusion Criteria:

* Patients presenting Miller class I or II gingival recession in the maxillary canines or premolars
* Visible cemento-enamel junction (CEJ) with pulp vitality;
* Patients presenting no signs of active periodontal disease and full-mouth plaque and bleeding score ≤20%;
* Patients older than 18 years old; probing depth ˂3 mm in the included teeth;
* Patients who agreed to participate and signed an informed consent form.

Exclusion Criteria:

* Patients presenting systemic problems that would contraindicate the surgical procedure;
* Patients taking medications known to interfere with the wound healing process or that contraindicate the surgical procedure;
* Smokers or pregnant women;
* Patients who underwent periodontal surgery in the area of interest;
* Patients with orthodontic therapy in progress.
D: Inclusion Criteria:

* The patient (male or female) must be 18 years or older
* The patient must be a candidate for bilateral root coverage procedure
* Recession defects are Miller Class I-II and do not vary more than 2 mm.
* At least one mm keratinized tissue is present.
* Patient shows sufficient plaque control (FMPS \< 20%).
* If patient is of child-bearing potential, the patient confirms not to be pregnant and agrees to take contraception for at least 6 months after surgery.
* The patient is able to comply with the study-related procedures such as exercising good oral hygiene and attending all follow-up procedures
* The patient is able to fully understand the nature of the proposed surgery and is able to provide a signed informed consent.

Exclusion Criteria:

* Patient is a heavy smoker (\> 10 cigarettes per day)
* Patient is an insulin dependent diabetic
* General contraindications for dental and/or surgical treatment are present.
* The patient has a history of malignancy, radiotherapy, or chemotherapy for malignancy within the past five years.
* The patient is pregnant or nursing
* The patient is taking medications or having treatments which have an effect on mucosal healing in general (e.g. steroids, large doses of anti-inflammatory drugs).
* The patient has a disease, which affects connective tissue metabolism (e.g. collagenases).
* The patient is allergic to collagen.
* Patients have participated in a clinical trial within the last six months.

Answer: D