Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: CSP #403 - Trial of Varicella Zoster Vaccine for the Prevention of Herpes Zoster and Its Complications
Brief Summary: The incidence and severity of HZ (or shingles), as well as the frequency and severity of its complications, increases markedly with increasing age. More than half of all cases occur in persons over the age of 60. Even without complications, HZ can interfere with an elderly patient's ability to perform essential activities of daily living, resulting in a loss of independence that is emotionally devastating and frequently irreversible. The most common complication of HZ in elderly persons is postherpetic neuralgia (PHN), which frequently results in disordered sleep, chronic fatigue, anxiety and severe depression. Antiviral therapy has a modest impact on the acute phase of HZ. However, it does not appear to prevent the development of PHN.

This study is a 5.5 year randomized, double-blind, placebo-controlled, efficacy trial to determine whether vaccination with live-attenuated Oka/Merck varicella-zoster decreases the incidence and/or severity of herpes zoster (HZ) and its complications in adults 60 years of age and older.


Options:
A: Arm Label: A - Live zoster vaccine; Type: ACTIVE_COMPARATOR; Interventions: Biological: Zostavax, Biological: Placebo | Arm Label: B - recombinant zoster vaccine; Type: ACTIVE_COMPARATOR; Interventions: Biological: HZ/su vaccine | Arm Label: C - Live zoster vaccine; Type: ACTIVE_COMPARATOR; Interventions: Biological: Zostavax, Biological: Placebo | Arm Label: D - recombinant zoster vaccine; Type: ACTIVE_COMPARATOR; Interventions: Biological: HZ/su vaccine | Intervention Type: BIOLOGICAL; Name: Zostavax; Assigned to Arm(s): A - Live zoster vaccine, C - Live zoster vaccine | Intervention Type: BIOLOGICAL; Name: HZ/su vaccine; Assigned to Arm(s): B - recombinant zoster vaccine, D - recombinant zoster vaccine | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): A - Live zoster vaccine, C - Live zoster vaccine
B: Arm Label: Arm 1; Type: EXPERIMENTAL; Interventions: Biological: Varicella-zoster vaccine | Arm Label: Arm 2; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Intervention Type: BIOLOGICAL; Name: Varicella-zoster vaccine; Assigned to Arm(s): Arm 1 | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Arm 2
C: Arm Label: SC HZ/su Group; Type: EXPERIMENTAL; Interventions: Biological: Herpes zoster vaccine GSK1437173A | Arm Label: IM HZ/su Group; Type: ACTIVE_COMPARATOR; Interventions: Biological: Herpes zoster vaccine GSK1437173A | Intervention Type: BIOLOGICAL; Name: Herpes zoster vaccine GSK1437173A; Assigned to Arm(s): IM HZ/su Group, SC HZ/su Group
D: Arm Label: Full Dose Subcutaneous; Type: ACTIVE_COMPARATOR; Interventions: Biological: ZOSTAVAX™ (Zoster Vaccine Live) Full Dose Subcutaneous, Biological: Intradermal Placebo | Arm Label: 1/3 Dose Subcutaneous; Type: EXPERIMENTAL; Interventions: Biological: ZOSTAVAX™ (Zoster Vaccine Live) 1/3 Dose Subcutaneous, Biological: Intradermal Placebo | Arm Label: Full Dose Intradermal; Type: EXPERIMENTAL; Interventions: Biological: ZOSTAVAX™ (Zoster Vaccine Live) Full Dose Intradermal, Biological: Full Dose Intradermal Placebo | Arm Label: 1/3 Dose Intradermal; Type: EXPERIMENTAL; Interventions: Biological: ZOSTAVAX™ (Zoster Vaccine Live) Partial Doses Intradermal, Biological: Intradermal Placebo | Arm Label: 1/10 Dose Intradermal; Type: EXPERIMENTAL; Interventions: Biological: ZOSTAVAX™ (Zoster Vaccine Live) Partial Doses Intradermal, Biological: Intradermal Placebo | Arm Label: 1/27 Dose Intradermal; Type: EXPERIMENTAL; Interventions: Biological: ZOSTAVAX™ (Zoster Vaccine Live) Partial Doses Intradermal, Biological: Intradermal Placebo | Intervention Type: BIOLOGICAL; Name: ZOSTAVAX™ (Zoster Vaccine Live) Full Dose Subcutaneous; Assigned to Arm(s): Full Dose Subcutaneous | Intervention Type: BIOLOGICAL; Name: ZOSTAVAX™ (Zoster Vaccine Live) 1/3 Dose Subcutaneous; Assigned to Arm(s): 1/3 Dose Subcutaneous | Intervention Type: BIOLOGICAL; Name: ZOSTAVAX™ (Zoster Vaccine Live) Full Dose Intradermal; Assigned to Arm(s): Full Dose Intradermal | Intervention Type: BIOLOGICAL; Name: ZOSTAVAX™ (Zoster Vaccine Live) Partial Doses Intradermal; Assigned to Arm(s): 1/10 Dose Intradermal, 1/27 Dose Intradermal, 1/3 Dose Intradermal | Intervention Type: BIOLOGICAL; Name: Full Dose Intradermal Placebo; Assigned to Arm(s): Full Dose Intradermal | Intervention Type: BIOLOGICAL; Name: Intradermal Placebo; Assigned to Arm(s): 1/10 Dose Intradermal, 1/27 Dose Intradermal, 1/3 Dose Intradermal, 1/3 Dose Subcutaneous, Full Dose Subcutaneous

Answer: B