Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: An Open-label, Randomized, Active Comparator-Controlled, Adaptive Parallel-group Phase 2 Study to Assess the Safety and Efficacy of Multiple Doses of ISIS 416858 Administered Subcutaneously to Patients Undergoing Total Knee Arthroplasty
Brief Summary: The purpose of this study is:

* To assess the safety and efficacy profile of ISIS-FXIRx, including incidence of bleeding and VTE, in patients undergoing total knee arthroplasty.
* To compare the efficacy and safety profile of ISIS-FXIRx in patients who achieve less than or equal to 0.2 U/mL FXI activity levels to that of enoxaparin.


Options:
A: Arm Label: ISIS-FXIRx Dose 2; Type: EXPERIMENTAL; Interventions: Drug: ISIS-FXIRx Dose #2 | Arm Label: ISIS-FXIRx Dose 3; Type: EXPERIMENTAL; Interventions: Drug: ISIS-FXIRx Dose #3 | Arm Label: Enoxaparin; Type: ACTIVE_COMPARATOR; Interventions: Drug: Enoxaparin | Intervention Type: DRUG; Name: ISIS-FXIRx Dose #2; Assigned to Arm(s): ISIS-FXIRx Dose 2 | Intervention Type: DRUG; Name: ISIS-FXIRx Dose #3; Assigned to Arm(s): ISIS-FXIRx Dose 3 | Intervention Type: DRUG; Name: Enoxaparin; Assigned to Arm(s): Enoxaparin
B: Arm Label: Apixaban; Type: ACTIVE_COMPARATOR; Interventions: Drug: Apixaban | Arm Label: Vitamin-K antagonists (Phenprocoumon); Type: ACTIVE_COMPARATOR; Interventions: Drug: Phenprocoumon | Intervention Type: DRUG; Name: Apixaban; Assigned to Arm(s): Apixaban | Intervention Type: DRUG; Name: Phenprocoumon; Assigned to Arm(s): Vitamin-K antagonists (Phenprocoumon)
C: Arm Label: Solacea_postHDF_1/1anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_postHDF_1/2anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: FX800_postHDF_1/1anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: FX800_postHDF_1/2anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_HD_1/1anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_HD_1/2anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: FX800_HD_1/1anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: FX800_HD_1/2anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy, Other: preparation of dialyzer | Arm Label: FX800_HD_1/2anticoagulation_albuprime; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy, Other: preparation of dialyzer | Arm Label: Evodial_HD_no anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Evodial_HD_no anticoagulation_albuprime; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy, Other: preparation of dialyzer | Arm Label: Solacea_preHDF_1/4anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_postHDF_1/4anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_HD_1/4anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_preHDF_no anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_postHDF_no anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_HD_no anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Intervention Type: DEVICE; Name: choice of dialyzer; Assigned to Arm(s): Evodial_HD_no anticoagulation, Evodial_HD_no anticoagulation_albuprime, FX800_HD_1/1anticoagulation, FX800_HD_1/2anticoagulation, FX800_HD_1/2anticoagulation_albuprime, FX800_postHDF_1/1anticoagulation, FX800_postHDF_1/2anticoagulation, Solacea_HD_1/1anticoagulation, Solacea_HD_1/2anticoagulation, Solacea_HD_1/4anticoagulation, Solacea_HD_no anticoagulation, Solacea_postHDF_1/1anticoagulation, Solacea_postHDF_1/2anticoagulation, Solacea_postHDF_1/4anticoagulation, Solacea_postHDF_no anticoagulation, Solacea_preHDF_1/4anticoagulation, Solacea_preHDF_no anticoagulation | Intervention Type: OTHER; Name: choice of dialysis mode; Assigned to Arm(s): Evodial_HD_no anticoagulation, Evodial_HD_no anticoagulation_albuprime, FX800_HD_1/1anticoagulation, FX800_HD_1/2anticoagulation, FX800_HD_1/2anticoagulation_albuprime, FX800_postHDF_1/1anticoagulation, FX800_postHDF_1/2anticoagulation, Solacea_HD_1/1anticoagulation, Solacea_HD_1/2anticoagulation, Solacea_HD_1/4anticoagulation, Solacea_HD_no anticoagulation, Solacea_postHDF_1/1anticoagulation, Solacea_postHDF_1/2anticoagulation, Solacea_postHDF_1/4anticoagulation, Solacea_postHDF_no anticoagulation, Solacea_preHDF_1/4anticoagulation, Solacea_preHDF_no anticoagulation | Intervention Type: OTHER; Name: choice of anticoagulation strategy; Assigned to Arm(s): Evodial_HD_no anticoagulation, Evodial_HD_no anticoagulation_albuprime, FX800_HD_1/1anticoagulation, FX800_HD_1/2anticoagulation, FX800_HD_1/2anticoagulation_albuprime, FX800_postHDF_1/1anticoagulation, FX800_postHDF_1/2anticoagulation, Solacea_HD_1/1anticoagulation, Solacea_HD_1/2anticoagulation, Solacea_HD_1/4anticoagulation, Solacea_HD_no anticoagulation, Solacea_postHDF_1/1anticoagulation, Solacea_postHDF_1/2anticoagulation, Solacea_postHDF_1/4anticoagulation, Solacea_postHDF_no anticoagulation, Solacea_preHDF_1/4anticoagulation, Solacea_preHDF_no anticoagulation | Intervention Type: OTHER; Name: preparation of dialyzer; Assigned to Arm(s): Evodial_HD_no anticoagulation_albuprime, FX800_HD_1/2anticoagulation, FX800_HD_1/2anticoagulation_albuprime
D: Arm Label: apixaban; Type: EXPERIMENTAL; Interventions: Drug: apixaban | Arm Label: warfarin; Type: EXPERIMENTAL; Interventions: Drug: warfarin | Intervention Type: DRUG; Name: apixaban; Assigned to Arm(s): apixaban | Intervention Type: DRUG; Name: warfarin; Assigned to Arm(s): warfarin

Answer: A