Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Pilot Trial on Efficacy and Safety of a Formula Salt With Very Low Sodium (Manlikang) in Reducing Salt Intake and Blood Pressure Among Patients With Hypertension in Community
Brief Summary: This study is a single arm trial with before-after comparison design. Three groups of patients with hypertension will be recruited: not taking antihypertension drugs and having normal renal function, taking antihypertension drugs and having normal renal function, and having abnormal renal function without regards of antihypertension drugs use. Each group includes 30 patients. Based on renal function test, the investigators provide the Manlikang containing potassium chloride to patients with normal renal function, and provide the Manlikang not containing potassium chloride to patients with abnormal renal function. All hypertension patients will use the formula salt with very low sodium (Manlikang) for six weeks, and will be followed up at 1, 2, 4 and 6 weeks. The primary outcome will be the decrease of patients' systolic blood pressure at the end of the trial.


Options:
A: Inclusion Criteria:

* Male or female aged 18 years or over
* History of hypertension diagnosed by a health professional - hypertension may be self-reported and antihypertensive drugs may or may not be used for management. There is no entry criterion based upon blood pressure measurements made at the baseline survey
* Eat most of their meals in the home
* Consent to participate

Exclusion Criteria:

* Participant or family member is using a potassium-sparing diuretic
* Participant or family member is using a potassium supplement
* Participant or family member has known significant renal dysfunction
* Participant or family member has other reason for concern about use of salt substitute
* Participant is not expected to live longer than 6 months from the date of assessment
* Another member of the household is already enrolled in the study
B: Inclusion Criteria:

* Disease history
* Prior stroke and/or
* Aged 60 years or over and with uncontrolled high blood pressure (systolic blood pressure \>=140 millimeters of mercury (mmHg) at visit if on blood pressure lowering medication; systolic blood pressure\>=160 millimeters of mercury (mmHg) if not on blood pressure lowering medication)
* Ownership of a phone by the participant or a household member

Exclusion Criteria:

* Participant or family member is using a potassium-sparing diuretic
* Participant or family member is using a potassium supplement
* Participant or family member has serious renal impairment
* Participant or family member has other reason for concern about use of salt substitute
* Participant eats most meals outside the home
* Participant is not expected to live longer than 6 months from the date of assessment as estimated by the village doctor
* Another family member living in the same household has already been included in the study
C: Inclusion Criteria:

* able to give informed consent
* in Sinus rhythm
* no anatomical limitation to take blood pressure

Exclusion Criteria:

* Atrial fibrillation
* Dialysis shunt
D: Inclusion Criteria:

* 50 to 75 years old
* No planning to move out of the community in the next three months
* Not cooking at home less than 3 times or one day during the study
* Willing to participate in the study and sign informed consent

Exclusion Criteria:

* Acute myocardial infarction, history of stroke in the past 3 months, history of malignancy or expected lifetime less than 1 year.
* Hypercortisolism or aldosteronism
* Acute disease, such as upper respiratory infection, fever and diarrhea.
* Incapable of communicating, such as deaf and dumb, dementia, mental disorder.
* Families taking salt substitute currently
* Not willing to use Manlikang in family
* Liver disfunction
* Anyone with abnormal serum potassium in family
* Anyone using potassium-retaining diuretics in family

Answer: D