Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Dose Response of FENO to Inhaled Steroids in Mild-to-moderate Asthma
Brief Summary: Asthma is a chronic disease, which means that it cannot be cured, but the investigators can use inhalers and tablets to control the symptoms. In asthma, the airways become inflamed and irritated which can cause coughing and make the airways tighten. This 'inflammation' is the root of the problem in asthma. Doctors have different ways to measure the inflammation in the airways. One way is to measure a gas called nitric oxide (NO) on the breath. This is made by the lungs when asthmatic inflammation is present. The investigators have been using NO as a test in research labs for many years, but there are still unanswered questions about how it changes between morning and night and how quickly medicines work on it. In most asthmatics, even small doses of inhaled steroids (preventers) can reduce the NO levels to normal, but in some people this does not seem to happen. The investigators now have portable NO machines that are designed for patients to use in the home. The investigators want to follow NO readings in patients with high levels to measure how they respond to different doses of steroid inhalers. The investigators hope this will help the investigators better understand asthma inflammation and treatments.


Options:
A: Arm Label: Reference Strategy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Inhaled corticosteroids | Arm Label: Biomarker Strategy; Type: EXPERIMENTAL; Interventions: Drug: Inhaled corticosteroids, Procedure: eNO measurement | Intervention Type: DRUG; Name: Inhaled corticosteroids; Assigned to Arm(s): Biomarker Strategy, Reference Strategy | Intervention Type: PROCEDURE; Name: eNO measurement; Assigned to Arm(s): Biomarker Strategy
B: Arm Label: High dose ICS; Type: ACTIVE_COMPARATOR; Interventions: Drug: Fluticasone Propionate | Arm Label: Low dose ICS; Type: ACTIVE_COMPARATOR; Interventions: Drug: Fluticasone Propionate | Intervention Type: DRUG; Name: Fluticasone Propionate; Assigned to Arm(s): Low dose ICS | Intervention Type: DRUG; Name: Fluticasone Propionate; Assigned to Arm(s): High dose ICS
C: Arm Label: Symptom-based adjustment; Type: EXPERIMENTAL; Interventions: Behavioral: Symptom-based adjustment | Arm Label: Biomarker-based adjustment; Type: EXPERIMENTAL; Interventions: Behavioral: Biomarker-based adjustment | Arm Label: Guideline-based adjustment; Type: EXPERIMENTAL; Interventions: Behavioral: Guideline-based adjustment | Intervention Type: BEHAVIORAL; Name: Symptom-based adjustment; Assigned to Arm(s): Symptom-based adjustment | Intervention Type: BEHAVIORAL; Name: Biomarker-based adjustment; Assigned to Arm(s): Biomarker-based adjustment | Intervention Type: BEHAVIORAL; Name: Guideline-based adjustment; Assigned to Arm(s): Guideline-based adjustment
D: Arm Label: FeNO group; Type: N/A; Interventions: Device: measurement of exhaled NO is used to guide treatment | Arm Label: Symptom group; Type: N/A; Interventions: N/A | Intervention Type: DEVICE; Name: measurement of exhaled NO is used to guide treatment; Assigned to Arm(s): FeNO group

Answer: B