Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Single Centre Randomised Controlled Study Into the Segmentation of Preimplantation Genetic Diagnosis (PGD) Treatment by Comparing Cumulative Pregnancy Rates Following Cryopreservation of All Genetically Transferable Embryos After PGD, Compared to Fresh Embryo Transfer Cumulative With Frozen Embryo Transfer of Genetically Transferable Embryos.
Brief Summary: A single centre observational study into the segmentation of preimplantation genetic diagnosis (PGD) treatment by comparing cumulative pregnancy rates following cryopreservation of all genetically transferable embryos after PGD, compared to fresh embryo transfer cumulative with frozen embryo transfer of genetically transferable embryos.The primary aim of the study is to assess the feasibility and effectiveness of segmentation in terms of pregnancy rates. The secondary aim is to assess the logistic advantage of segmentation in PGD cycles.

Experimental questions

1. Is the cumulative live birth rate rate of a single PGD treatment when all genetically transferable embryos are cryopreserved by vitrification prior to consecutive in utero transfer in unstimulated cycles, superior to PGD treatment with fresh embryo transfer cumulative with transfer of supernumerary cryopreserved embryos?
2. Does the technique of segmentation allow better planning of DNA amplification and genetic analysis?

Design The proposed design is a pragmatic, prospective randomised controlled trial


Options:
A: Arm Label: freeze all embryos following PGD; Type: EXPERIMENTAL; Interventions: Procedure: elective cryopreservation of available embryos after PGD | Arm Label: elective fresh embryo transfer; Type: ACTIVE_COMPARATOR; Interventions: Procedure: PGD and elective fresh embryo transfer plus cryopreservation of supernumerary available embryos after PGD | Intervention Type: PROCEDURE; Name: elective cryopreservation of available embryos after PGD; Assigned to Arm(s): freeze all embryos following PGD | Intervention Type: PROCEDURE; Name: PGD and elective fresh embryo transfer plus cryopreservation of supernumerary available embryos after PGD; Assigned to Arm(s): elective fresh embryo transfer
B: Arm Label: Fresh transfer; Type: ACTIVE_COMPARATOR; Interventions: Procedure: fresh transfer | Arm Label: Deferred-frozen embryo transfer; Type: EXPERIMENTAL; Interventions: Procedure: Deferred-frozen embryo transfer | Intervention Type: PROCEDURE; Name: fresh transfer; Assigned to Arm(s): Fresh transfer | Intervention Type: PROCEDURE; Name: Deferred-frozen embryo transfer; Assigned to Arm(s): Deferred-frozen embryo transfer
C: Arm Label: Blastocyst transfer in PTEC cycle; Type: EXPERIMENTAL; Interventions: Procedure: Embryo cryopreservation | Arm Label: Fresh blastocyst transfer; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Fresh blastocyst transfer | Intervention Type: PROCEDURE; Name: Embryo cryopreservation; Assigned to Arm(s): Blastocyst transfer in PTEC cycle | Intervention Type: PROCEDURE; Name: Fresh blastocyst transfer; Assigned to Arm(s): Fresh blastocyst transfer
D: Arm Label: Frozen Embryo Transfer with PGD; Type: EXPERIMENTAL; Interventions: Other: PGD | Arm Label: Fresh Embryo Transfer with PGD; Type: EXPERIMENTAL; Interventions: Other: PGD | Intervention Type: OTHER; Name: PGD; Assigned to Arm(s): Fresh Embryo Transfer with PGD, Frozen Embryo Transfer with PGD

Answer: A