Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Phase III Trial Comparing Dexamethasone (DEX) to the Combination of DEX + CC-5013 in Patients With Previously Untreated Multiple Myeloma
Brief Summary: RATIONALE: Drugs used in chemotherapy such as dexamethasone use different ways to stop cancer cells from dividing so they stop growing or die. Lenalidomide may stop the growth of multiple myeloma by stopping blood flow to the tumor. It is not yet known whether dexamethasone is more effective with or without lenalidomide in treating multiple myeloma.

PURPOSE: This randomized phase III trial is studying dexamethasone and lenalidomide to see how well they work compared to dexamethasone alone in treating patients with previously untreated stage I, stage II, or stage III multiple myeloma.


Options:
A: Arm Label: A; Type: ACTIVE_COMPARATOR; Interventions: Drug: Melphalan/Prednisone/Velcade | Arm Label: B; Type: EXPERIMENTAL; Interventions: Drug: Thalidomide/Prednisone/Velcade | Intervention Type: DRUG; Name: Melphalan/Prednisone/Velcade; Assigned to Arm(s): A | Intervention Type: DRUG; Name: Thalidomide/Prednisone/Velcade; Assigned to Arm(s): B
B: Arm Label: Bortezomib and Dexamethasone (VD); Type: EXPERIMENTAL; Interventions: Drug: Bortezomib, Drug: Dexamethasone | Arm Label: Bortezomib, Thalidomide, and Dexamethasone (VTD); Type: EXPERIMENTAL; Interventions: Drug: Bortezomib, Drug: Dexamethasone, Drug: Thalidomide | Arm Label: Bortezomib, Melphalan and Prednisone (VMP); Type: EXPERIMENTAL; Interventions: Drug: Bortezomib, Drug: Melphalan, Drug: Prednisone | Intervention Type: DRUG; Name: Bortezomib; Assigned to Arm(s): Bortezomib and Dexamethasone (VD), Bortezomib, Melphalan and Prednisone (VMP), Bortezomib, Thalidomide, and Dexamethasone (VTD) | Intervention Type: DRUG; Name: Dexamethasone; Assigned to Arm(s): Bortezomib and Dexamethasone (VD), Bortezomib, Thalidomide, and Dexamethasone (VTD) | Intervention Type: DRUG; Name: Melphalan; Assigned to Arm(s): Bortezomib, Melphalan and Prednisone (VMP) | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): Bortezomib, Melphalan and Prednisone (VMP) | Intervention Type: DRUG; Name: Thalidomide; Assigned to Arm(s): Bortezomib, Thalidomide, and Dexamethasone (VTD)
C: Arm Label: Part 1: VMP+Siltuximab 11 mg/kg; Type: EXPERIMENTAL; Interventions: Drug: Siltuximab11 mg/kg, Drug: Velcade (bortezomib), Drug: Melphalan, Drug: Prednisone | Arm Label: Part 2, Arm A: VMP+Siltuximab 8.3 mg/kg or 11 mg/kg; Type: EXPERIMENTAL; Interventions: Drug: Siltuximab 8.3 mg/kg or 11 mg/kg, Drug: Velcade (bortezomib), Drug: Melphalan, Drug: Prednisone | Arm Label: Part 2, Arm B: VMP; Type: ACTIVE_COMPARATOR; Interventions: Drug: Velcade (bortezomib), Drug: Melphalan, Drug: Prednisone | Intervention Type: DRUG; Name: Siltuximab11 mg/kg; Assigned to Arm(s): Part 1: VMP+Siltuximab 11 mg/kg | Intervention Type: DRUG; Name: Siltuximab 8.3 mg/kg or 11 mg/kg; Assigned to Arm(s): Part 2, Arm A: VMP+Siltuximab 8.3 mg/kg or 11 mg/kg | Intervention Type: DRUG; Name: Velcade (bortezomib); Assigned to Arm(s): Part 1: VMP+Siltuximab 11 mg/kg | Intervention Type: DRUG; Name: Velcade (bortezomib); Assigned to Arm(s): Part 2, Arm A: VMP+Siltuximab 8.3 mg/kg or 11 mg/kg | Intervention Type: DRUG; Name: Melphalan; Assigned to Arm(s): Part 1: VMP+Siltuximab 11 mg/kg | Intervention Type: DRUG; Name: Melphalan; Assigned to Arm(s): Part 2, Arm A: VMP+Siltuximab 8.3 mg/kg or 11 mg/kg | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): Part 1: VMP+Siltuximab 11 mg/kg | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): Part 2, Arm A: VMP+Siltuximab 8.3 mg/kg or 11 mg/kg | Intervention Type: DRUG; Name: Velcade (bortezomib); Assigned to Arm(s): Part 2, Arm B: VMP | Intervention Type: DRUG; Name: Melphalan; Assigned to Arm(s): Part 2, Arm B: VMP | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): Part 2, Arm B: VMP
D: Arm Label: Arm I; Type: EXPERIMENTAL; Interventions: Drug: dexamethasone, Drug: lenalidomide | Arm Label: Arm II; Type: ACTIVE_COMPARATOR; Interventions: Drug: dexamethasone, Other: placebo | Intervention Type: DRUG; Name: dexamethasone; Assigned to Arm(s): Arm I, Arm II | Intervention Type: DRUG; Name: lenalidomide; Assigned to Arm(s): Arm I | Intervention Type: OTHER; Name: placebo; Assigned to Arm(s): Arm II

Answer: D