Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized Trial to Determine if a Pre-operative Wash With a Chlorhexidine Gluconate Cloth and Chlorhexidine Gluconate Vaginal Scrub Reduces Infectious Morbidity in Patients Undergoing Cesarean Section After Labor
Brief Summary: Surgical site infections (SSI) are the second most common cause of nosocomial infections accounting for 15% of all nosocomial infections among hospitalized patients and 38% of nosocomial infections in surgical patients. In obstetric patients, infectious morbidity (i.e. SSI, endometritis) occurs in 5-10% of cesarean sections, which is 5-fold higher than vaginal deliveries. Additionally, infectious morbidity is thought to be highest in those patients who have cesarean sections after undergoing labor.

Chlorhexidine, a chemical antiseptic effective on gram positive and gram negative bacteria, reduces skin microflora/colonization but it is not clear if it decreases the risk of SSI.

Historically, chlorhexidine has been studied and used in orthopedic and cardiac implant surgeries. Research on the use of chlorhexidine for SSI prevention in cesarean sections is limited. This study intends to evaluate the effectiveness of use of both chlorhexidine gluconate (CHG) wipe and vaginal scrub in reducing SSI in patients undergoing cesarean section that have previously been laboring. Patients will be randomized to one of two groups: wash with both a pre-operative CHG cloth prior to surgery and chlorhexidine gluconate vaginal scrub in addition to standard preoperative scrub as compared to standard preoperative scrub alone.


Options:
A: Arm Label: Vag prep; Type: EXPERIMENTAL; Interventions: Procedure: Vaginal cleansing before cesarean delivery | Intervention Type: PROCEDURE; Name: Vaginal cleansing before cesarean delivery; Assigned to Arm(s): Vag prep
B: Arm Label: Chlorhexidine gluconate vaginal scrub; Type: EXPERIMENTAL; Interventions: Drug: EZ scrub vaginal chlorhexidine 4% solution | Arm Label: Povidone-iodine vaginal scrub; Type: ACTIVE_COMPARATOR; Interventions: Drug: 10% provodine-iodine vaginal preparation | Intervention Type: DRUG; Name: EZ scrub vaginal chlorhexidine 4% solution; Assigned to Arm(s): Chlorhexidine gluconate vaginal scrub | Intervention Type: DRUG; Name: 10% provodine-iodine vaginal preparation; Assigned to Arm(s): Povidone-iodine vaginal scrub
C: Arm Label: Chlorhexidine gluconate vaginal scrub and cloth; Type: EXPERIMENTAL; Interventions: Drug: 2% chlorhexidine gluconate cloth, Drug: 4% Chlorhexidine gluconate vaginal scrub | Arm Label: Standard Treatment; Type: ACTIVE_COMPARATOR; Interventions: Drug: 2% chlorhexidine gluconate cloth | Intervention Type: DRUG; Name: 2% chlorhexidine gluconate cloth; Assigned to Arm(s): Chlorhexidine gluconate vaginal scrub and cloth, Standard Treatment | Intervention Type: DRUG; Name: 4% Chlorhexidine gluconate vaginal scrub; Assigned to Arm(s): Chlorhexidine gluconate vaginal scrub and cloth
D: Arm Label: Chlorhexidine-alcohol; Type: ACTIVE_COMPARATOR; Interventions: Drug: Chlorhexidine-alcohol | Arm Label: Povidine-iodine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Povidine-iodine | Arm Label: Saline; Type: PLACEBO_COMPARATOR; Interventions: Drug: Sterile saline | Intervention Type: DRUG; Name: Chlorhexidine-alcohol; Assigned to Arm(s): Chlorhexidine-alcohol | Intervention Type: DRUG; Name: Povidine-iodine; Assigned to Arm(s): Povidine-iodine | Intervention Type: DRUG; Name: Sterile saline; Assigned to Arm(s): Saline

Answer: C