Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Multicenter Randomized Trial to Evaluate the Efficacy and Safety of Three Different Prophylactic Treatments of Postoperative Nausea and Vomiting in Patients Undergoing Vitrectomy Under Local Anesthesia
Brief Summary: Vitreoretinal surgery is associated with a considerable incidence of postoperative nausea and vomiting (PONV), which is reported to be as high as 60%. Reasons for this high incidence may be the long duration of surgery and anesthesia and the high degree of manipulation of the eye. Postoperative vomiting after vitrectomy is an important risk factor for the onset of several complications, such as suprachoroidal hemorrhage, with disastrous visual consequences.

To date there is no evidence as to the possible protective effect of anti-emetic therapy with regard to interventions of vitrectomy performed under local anesthesia.

In this prospective, randomized, multicenter, double blind study, we evaluated the efficacy of Ondansetron alone, Dexamethasone alone and in combination in controlling nausea and vomiting in patients undergoing vitrectomy under local anesthesia.


Options:
A: Inclusion Criteria:

* All patients undergoing breast surgery for carcinoma breast.
* Patients between ages 18 to 60 years.
* ASA I \\ II \\ III
* Patients weight between 40 and 70 kilograms.

Exclusion Criteria:

* Patient refusing consent
* Prophylactic anti emetic drug administration during intraoperative period
* Known case of prolonged QTc interval
* Known case decompensated cardiomyopathy
* Known case of cardiac arrhythmia or bundle branch block
* Case of congestive heart failure with left ventricular ejection fraction \<40%
* Abnormal serum level of potassium, calcium, magnesium
B: Inclusion Criteria:

* Patient is at least 18 years of age.
* Patient is scheduled to undergo open abdominal surgery requiring overnight hospital stay (24-hour hospital stay after end of surgery).
* Patient is scheduled to receive general anesthesia.
* Patient is scheduled to receive postoperative opioids.
C: Inclusion Criteria:

* patients planned for elective laparoscopic hernia repair (TAPP)
* Unilateral inguinal or femoral hernia
* ASA class I-II
* Read and speak Danish

Exclusion Criteria:

* Acute hernia operation
* Operation for other hernias with mesh during the same procedure
* Endocrine disease (diabetes, adrenal insufficiency etc.)
* fever/infection within the first 10 days before operation
* Poor compliance
* No signed consent form
* Daily intake of opioids or anxiolytic drugs
* Manic episodes
* Use medicine against glaucoma
* Use thiazide or loop diuretics
* Vaccination within the last 14 days
D: Inclusion Criteria:

* Age 18 or older with an American Society of Anesthesiologists (ASA) physical status of I to II
* Scheduled for vitrectomy under local anesthesia

Exclusion Criteria:

* Hypersensitivity to study drug or rescue medication
* Preoperative score for nausea greater than 4 out of 10 points
* Subjects who suffer from chronic nausea and/or vomiting
* Severe hepatic insufficiency (Child-Pugh score \> 9)
* Other antiemetic within 12 hours prior to surgery
* Patients unable to undergo a local anesthetic
* Subjects with clinically significant or unstable cardiac, respiratory, hepatic, renal, or other major organ system disease
* Psychotic illness or depression
* Addiction to illicit substances or alcohol
* Non-psychotic emotional disorders
* Pregnant or lactating
* Subjects who, in the opinion of the investigator, would experience an unacceptable risk from administration of study drug

Answer: D