Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase III Study of Standard Fractionation Radiotherapy With Concurrent High-Dose Cisplatin Versus Accelerated Fractionation Radiotherapy With Panitumumab in Patients With Locally Advanced Stage III and IV Squamous Cell Carcinoma of the Head and Neck
Brief Summary: RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy in higher doses over a shorter period of time may kill more tumor cells and have fewer side effects. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as panitumumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether giving standard radiation therapy together with high-dose cisplatin is more effective than giving higher-dose radiation therapy together with panitumumab in treating patients with locally advanced head and neck cancer.

PURPOSE: This randomized phase III trial is comparing two radiation therapy regimens to see how well they work when given together with cisplatin or panitumumab in treating patients with locally advanced stage III or stage IV head and neck cancer.


Options:
A: Arm Label: Cabazitaxel; Type: EXPERIMENTAL; Interventions: Drug: Cabazitaxel | Arm Label: Methotrexate; Type: ACTIVE_COMPARATOR; Interventions: Drug: Methotrexate | Intervention Type: DRUG; Name: Cabazitaxel; Assigned to Arm(s): Cabazitaxel | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): Methotrexate
B: Arm Label: Arm I; Type: ACTIVE_COMPARATOR; Interventions: Drug: cisplatin, Radiation: 3-dimensional conformal radiation therapy, Radiation: intensity-modulated radiation therapy | Arm Label: Arm II; Type: EXPERIMENTAL; Interventions: Biological: panitumumab, Radiation: 3-dimensional conformal radiation therapy, Radiation: accelerated radiation therapy, Radiation: intensity-modulated radiation therapy | Intervention Type: BIOLOGICAL; Name: panitumumab; Assigned to Arm(s): Arm II | Intervention Type: DRUG; Name: cisplatin; Assigned to Arm(s): Arm I | Intervention Type: RADIATION; Name: 3-dimensional conformal radiation therapy; Assigned to Arm(s): Arm I, Arm II | Intervention Type: RADIATION; Name: accelerated radiation therapy; Assigned to Arm(s): Arm II | Intervention Type: RADIATION; Name: intensity-modulated radiation therapy; Assigned to Arm(s): Arm I, Arm II
C: Arm Label: ARM A; Type: EXPERIMENTAL; Interventions: Drug: docetaxel - cisplatin - 5-fluorouracil, Radiation: radiotherapy, Drug: cetuximab | Arm Label: ARM B; Type: ACTIVE_COMPARATOR; Interventions: Drug: cisplatin, Radiation: radiotherapy | Intervention Type: DRUG; Name: docetaxel - cisplatin - 5-fluorouracil; Assigned to Arm(s): ARM A | Intervention Type: RADIATION; Name: radiotherapy; Assigned to Arm(s): ARM A | Intervention Type: DRUG; Name: cetuximab; Assigned to Arm(s): ARM A | Intervention Type: DRUG; Name: cisplatin; Assigned to Arm(s): ARM B | Intervention Type: RADIATION; Name: radiotherapy; Assigned to Arm(s): ARM B
D: Arm Label: Arm A Patient FIT; Type: ACTIVE_COMPARATOR; Interventions: Drug: Cisplatin, Radiation: IMRT | Arm Label: Arm B Patient FIT; Type: EXPERIMENTAL; Interventions: Drug: Cetuximab, Drug: avelumab, Radiation: IMRT | Arm Label: Arm C Patient UNFIT; Type: EXPERIMENTAL; Interventions: Drug: Cetuximab, Drug: avelumab, Radiation: IMRT | Arm Label: Arm D Patient UNFIT; Type: ACTIVE_COMPARATOR; Interventions: Drug: Cetuximab, Radiation: IMRT | Intervention Type: DRUG; Name: Cetuximab; Assigned to Arm(s): Arm B Patient FIT, Arm C Patient UNFIT, Arm D Patient UNFIT | Intervention Type: DRUG; Name: avelumab; Assigned to Arm(s): Arm B Patient FIT, Arm C Patient UNFIT | Intervention Type: DRUG; Name: Cisplatin; Assigned to Arm(s): Arm A Patient FIT | Intervention Type: RADIATION; Name: IMRT; Assigned to Arm(s): Arm A Patient FIT, Arm B Patient FIT, Arm C Patient UNFIT, Arm D Patient UNFIT

Answer: B