Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Bioavailability of Folic Acid and L-5-methyltetrahydrofolic Acid in Fortified Bread: a Randomized Placebo-controlled Trial
Brief Summary: Folic acid is the synthetic form of vitamin folate. Because of its high stability and bioavailability, it is the form of folate added to bread in Canada to reduce birth defects. There are health concerns about long-term folic acid consumption. Another form of folate, L-5-methyltetrahydrofolic acid (L-5-MTHF) has become available which does not have these health concerns. Unfortunately L-5-MTHF is not as stable as folic acid, but the investigators have developed a method to stabilize L-5-MTHF in food. The investigators plan to conduct a randomized trial to compare the bioavailability of bread fortified with L-5-MTHF versus folic acid.

The investigators hypothesize that bread fortified with L-5-MTHF will increase red cell folate over 16 weeks to the same extent as bread fortified with equimolar folic acid.


Options:
A: Arm Label: corn-soy-blend; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: corn-soy blend, Dietary Supplement: iron, Dietary Supplement: folic acid | Arm Label: corn-soy-blend + multiple micronutrients; Type: EXPERIMENTAL; Interventions: Dietary Supplement: corn-soy blend, Dietary Supplement: UNIMMAP | Arm Label: ready-to-use supplementary food; Type: EXPERIMENTAL; Interventions: Dietary Supplement: ready-to-use supplementary food | Intervention Type: DIETARY_SUPPLEMENT; Name: ready-to-use supplementary food; Assigned to Arm(s): ready-to-use supplementary food | Intervention Type: DIETARY_SUPPLEMENT; Name: corn-soy blend; Assigned to Arm(s): corn-soy-blend, corn-soy-blend + multiple micronutrients | Intervention Type: DIETARY_SUPPLEMENT; Name: iron; Assigned to Arm(s): corn-soy-blend | Intervention Type: DIETARY_SUPPLEMENT; Name: folic acid; Assigned to Arm(s): corn-soy-blend | Intervention Type: DIETARY_SUPPLEMENT; Name: UNIMMAP; Assigned to Arm(s): corn-soy-blend + multiple micronutrients
B: Arm Label: Zinc-fortified bread (10 mg zinc/d); Type: EXPERIMENTAL; Interventions: Dietary Supplement: Zinc-fortified bread, Dietary Supplement: Placebo supplement | Arm Label: Zinc fortified bread (20 mg zinc/d); Type: EXPERIMENTAL; Interventions: Dietary Supplement: Zinc-fortified bread, Dietary Supplement: Placebo supplement | Arm Label: Zinc supplemented group; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Zinc supplement, Dietary Supplement: Non-fortified bread | Arm Label: Non-fortified group; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Non-fortified bread, Dietary Supplement: Placebo supplement | Intervention Type: DIETARY_SUPPLEMENT; Name: Zinc-fortified bread; Assigned to Arm(s): Zinc fortified bread (20 mg zinc/d), Zinc-fortified bread (10 mg zinc/d) | Intervention Type: DIETARY_SUPPLEMENT; Name: Zinc supplement; Assigned to Arm(s): Zinc supplemented group | Intervention Type: DIETARY_SUPPLEMENT; Name: Non-fortified bread; Assigned to Arm(s): Non-fortified group, Zinc supplemented group | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo supplement; Assigned to Arm(s): Non-fortified group, Zinc fortified bread (20 mg zinc/d), Zinc-fortified bread (10 mg zinc/d)
C: Arm Label: Folic acid; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Folic acid | Arm Label: L-5-MTHF; Type: EXPERIMENTAL; Interventions: Dietary Supplement: L-5-MTHF | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: Folic acid; Assigned to Arm(s): Folic acid | Intervention Type: DIETARY_SUPPLEMENT; Name: L-5-MTHF; Assigned to Arm(s): L-5-MTHF | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo
D: Intervention Type: PROCEDURE; Name: consumption of fortified bread; Assigned to Arm(s): N/A

Answer: C