Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomised Controlled Cross-over Trial to Evaluate Evening Versus Morning Administration of a Cardiovascular Polypill
Brief Summary: Background and rationale:

In clinical practice, antihypertensives are generally prescribed for use in the morning, whereas some statins are recommended for use in the evening. There is evidence that the reduction in LDL cholesterol achieved with some statins is superior when taken in the night, but it is unclear whether the additional reduction in LDL cholesterol(and the reported improvement in BP control when aspirin is taken in the evening) is offset by a reduction in adherence when taking medication in the evening. Current product labelling recommends night use for simvastatin and does not state a timing preference for aspirin or blood pressure lowering medicines. There is therefore uncertainty concerning the best timing of administration of the polypill. This uncertainty will be addressed by this trial.

Trial design:

Randomised, open label cross over trial (n=75) of the polypill in the morning compared with the evening administration compared with individual agent administration (acetylsalicylic acid and blood pressure lowering agents in the morning, and statin in the evening) in individuals at high risk of cardiovascular disease. Patients will be recruited to the RHP 2c (acetylsalicylic acid 75mg, simvastatin 40mg, lisinopril 10mg, hydrochlorthiazide 12.5mg), and will be randomly allocated to the sequence of time of administration.


Options:
A: Arm Label: Polypill in the morning; Type: EXPERIMENTAL; Interventions: Drug: Cardiovascular Agents | Arm Label: Polypill in the evening; Type: EXPERIMENTAL; Interventions: Drug: Cardiovascular Agents | Arm Label: Individual agents of the polypill); Type: ACTIVE_COMPARATOR; Interventions: Drug: Cardiovascular Agents | Intervention Type: DRUG; Name: Cardiovascular Agents; Assigned to Arm(s): Individual agents of the polypill), Polypill in the evening, Polypill in the morning
B: Arm Label: The Red Heart Pill 2b (Polypill) (A); Type: EXPERIMENTAL; Interventions: Drug: Red Heart Pill 2b (Polypill) | Arm Label: Standard Practice Group (B); Type: ACTIVE_COMPARATOR; Interventions: Other: Standard Practice | Intervention Type: DRUG; Name: Red Heart Pill 2b (Polypill); Assigned to Arm(s): The Red Heart Pill 2b (Polypill) (A) | Intervention Type: OTHER; Name: Standard Practice; Assigned to Arm(s): Standard Practice Group (B)
C: Arm Label: 1, POLYCAP; Type: EXPERIMENTAL; Interventions: Drug: POLYCAP | Arm Label: 2 B; Type: ACTIVE_COMPARATOR; Interventions: Drug: Thiazides | Arm Label: 3 C; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ramipril with Thiazide | Arm Label: 4 D; Type: ACTIVE_COMPARATOR; Interventions: Drug: Thiazide plus atenolol | Arm Label: 5, E; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ramipril plus atenolol | Arm Label: 6, F; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ramipril plus atenolol plus thiazide | Arm Label: 7,G; Type: ACTIVE_COMPARATOR; Interventions: Drug: Thiazide + Ramipril+Atenolol+Aspirin | Arm Label: 8,H; Type: ACTIVE_COMPARATOR; Interventions: Drug: Simvastatin | Arm Label: 9,A; Type: ACTIVE_COMPARATOR; Interventions: Drug: aspirin | Intervention Type: DRUG; Name: Thiazides; Assigned to Arm(s): 2 B | Intervention Type: DRUG; Name: Ramipril with Thiazide; Assigned to Arm(s): 3 C | Intervention Type: DRUG; Name: Thiazide plus atenolol; Assigned to Arm(s): 4 D | Intervention Type: DRUG; Name: Ramipril plus atenolol; Assigned to Arm(s): 5, E | Intervention Type: DRUG; Name: Ramipril plus atenolol plus thiazide; Assigned to Arm(s): 6, F | Intervention Type: DRUG; Name: POLYCAP; Assigned to Arm(s): 1, POLYCAP | Intervention Type: DRUG; Name: Thiazide + Ramipril+Atenolol+Aspirin; Assigned to Arm(s): 7,G | Intervention Type: DRUG; Name: Simvastatin; Assigned to Arm(s): 8,H | Intervention Type: DRUG; Name: aspirin; Assigned to Arm(s): 9,A
D: Arm Label: OM40/AML10; Type: EXPERIMENTAL; Interventions: Drug: Olmesartan medoxomil, Drug: Amlodipine | Arm Label: OM40/HCTZ25; Type: ACTIVE_COMPARATOR; Interventions: Drug: Olmesartan medoxomil, Drug: Hydrochlorothiazide | Arm Label: AML10/HCTZ25; Type: ACTIVE_COMPARATOR; Interventions: Drug: Amlodipine, Drug: Hydrochlorothiazide | Arm Label: OM40/AML10/HCTZ25; Type: ACTIVE_COMPARATOR; Interventions: Drug: Olmesartan medoxomil, Drug: Amlodipine, Drug: Hydrochlorothiazide | Intervention Type: DRUG; Name: Olmesartan medoxomil; Assigned to Arm(s): OM40/AML10, OM40/AML10/HCTZ25, OM40/HCTZ25 | Intervention Type: DRUG; Name: Amlodipine; Assigned to Arm(s): AML10/HCTZ25, OM40/AML10, OM40/AML10/HCTZ25 | Intervention Type: DRUG; Name: Hydrochlorothiazide; Assigned to Arm(s): AML10/HCTZ25, OM40/AML10/HCTZ25, OM40/HCTZ25

Answer: A