Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: N/A
Brief Summary: Rationale: About 80% of stroke patients suffer motor impairments, but current therapies have limited effects on motor recovery. Therefore, investigating new potential therapeutic approaches is crucial. Transcranial Direct Current Stimulation (tDCS) is a form of non-invasive electrical stimulation where a weak current is applied through electrodes over the scalp. This stimulation is known to (1) induce changes in neuronal excitability -which can last up to one day with late LTP-like plasticity protocols- in a polarity and site-specific manner, and (2) facilitate motor learning and stroke recovery. However, it is unknown how the motor cortex excitability changes that follow tDCS relate to the increase in motor learning and recovery potential. The currently upheld hypothesis is that motor learning needs to be synchronized in time with electrical stimulation (paired stimulation), but recent results from our lab suggest that tDCS also increases skill learning after stimulation has ended (unpaired stimulation). If this is true, tDCS has a much larger therapeutic window and is a more valuable clinical tool than currently believed. Therefore, the investigators want to investigate how late LTP-like plasticity tDCS affects the increase in skill learning normally seen with tDCS when applied 24 hours before training. The outcome of this study can provide important guidelines on effective motor therapy during stroke rehabilitation.

Objective: Identify the effect of late LTP-like plasticity tDCS in chronic stroke patients on skill learning 24 hours later.

Study design: Double-blinded, randomized between-subjects trials. Study population: Chronic stroke patients. Main study parameters/endpoints: The main objective of the study is to determine the effect of late LTP-like plasticity tDCS on skill learning 24 hours later. As a motor learning paradigm, the investigators will use a circuit tracking task which chronic stroke patients perform better if tDCS is applied concurrently. During this task, patients have to trace a cursor over a circuit as fast and accurately as possible by moving a computer mouse. Skill will be quantified by calculating a combined speed/ accuracy score and skill improvement compared to baseline (LI; the learning index) will be compared between the sham, conventional unpaired tDCS, conventional paired tDCS groups and the late LTP-like plasticity tDCS groups.


Options:
A: Arm Label: Sham; Type: PLACEBO_COMPARATOR; Interventions: Device: tDCS | Arm Label: tDCS; Type: EXPERIMENTAL; Interventions: Device: tDCS | Intervention Type: DEVICE; Name: tDCS; Assigned to Arm(s): Sham, tDCS
B: Arm Label: Sham; Type: SHAM_COMPARATOR; Interventions: Device: Sham | Arm Label: Conventional Paired tDCS; Type: ACTIVE_COMPARATOR; Interventions: Device: Conventional Paired tDCS | Arm Label: Conventional Unpaired tDCS; Type: ACTIVE_COMPARATOR; Interventions: Device: Conventional Unpaired tDCS | Arm Label: Late LTP-like Plasticity tDCS; Type: EXPERIMENTAL; Interventions: Device: Late LTP-like Plasticity tDCS | Intervention Type: DEVICE; Name: Sham; Assigned to Arm(s): Sham | Intervention Type: DEVICE; Name: Conventional Paired tDCS; Assigned to Arm(s): Conventional Paired tDCS | Intervention Type: DEVICE; Name: Conventional Unpaired tDCS; Assigned to Arm(s): Conventional Unpaired tDCS | Intervention Type: DEVICE; Name: Late LTP-like Plasticity tDCS; Assigned to Arm(s): Late LTP-like Plasticity tDCS
C: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Device: Active transcranial Direct Current Stimulation / Constraint Induced Movement Therapy | Arm Label: 2; Type: SHAM_COMPARATOR; Interventions: Device: Sham transcranial Direct Current Stimulation / Constraint Induced Movement Therapy | Intervention Type: DEVICE; Name: Active transcranial Direct Current Stimulation / Constraint Induced Movement Therapy; Assigned to Arm(s): 1 | Intervention Type: DEVICE; Name: Sham transcranial Direct Current Stimulation / Constraint Induced Movement Therapy; Assigned to Arm(s): 2
D: Arm Label: Prism adaptation + anodal tDCS; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Prism Adaptation, Device: Anodal tDCS | Arm Label: Prism Adaptation + Sham tDCS; Type: PLACEBO_COMPARATOR; Interventions: Behavioral: Prism Adaptation, Device: Sham tDCS | Arm Label: Prism adaptation + no tDCS; Type: PLACEBO_COMPARATOR; Interventions: Behavioral: Prism Adaptation | Intervention Type: BEHAVIORAL; Name: Prism Adaptation; Assigned to Arm(s): Prism Adaptation + Sham tDCS, Prism adaptation + anodal tDCS, Prism adaptation + no tDCS | Intervention Type: DEVICE; Name: Anodal tDCS; Assigned to Arm(s): Prism adaptation + anodal tDCS | Intervention Type: DEVICE; Name: Sham tDCS; Assigned to Arm(s): Prism Adaptation + Sham tDCS

Answer: B