Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Randomized Trial Comparing Near Versus Distance Activities While Patching for Amblyopia in Children 3 to <7 Years Old
Brief Summary: Ths purpose of this study is to determine whether "near" activities enhance the effect of patching on visual acuity improvement in strabismic and anisometropic amblyopia when compared with "distance" activities in the treatment of moderate amblyopia and severe amblyopia in children 3 to \<7 years old.


Options:
A: Inclusion Criteria:

* Age 3 to \<7 years
* Able to perform visual acuity using the ATS single-surround HOTV protocol
* Amblyopia associated with strabismus (comitant or incomitant), anisometropia, or both
* Visual acuity in the amblyopic eye 20/40 to 20/400 inclusive
* Visual acuity in the sound eye \>20/40
* Inter-eye acuity difference \>3 logMAR lines
* Cycloplegic refraction and ocular examination within 2 months prior to enrollment

Exclusion Criteria:

* No amblyopia treatment (other than spectacles) in the past month and no more than one month of amblyopia treatment in the past 6 months
* No current vision therapy or orthoptics
* No ocular cause for reduced visual acuity
* No myopia more than a spherical equivalent of -6.00 D
* No prior intraocular or refractive surgery
* No known skin reactions to patch or bandage adhesives
B: Inclusion Criteria:

* Age \< 7 years
* Able to measure surrounded single optotype visual acuity using the ATS single-surround HOTV protocol (this will in effect exclude all patients \<2 years old and many \<3 years old)
* Amblyopia associated with strabismus, anisometropia, or both
* If anisometropia is present (as per protocol definition), refractive error corrected with spectacles for a minimum of 4 weeks
* Visual acuity in the amblyopic eye \< 20/40 and \>20/80
* Visual acuity in the sound eye \> 20/40 and inter-eye acuity difference \>3 logMAR lines

Exclusion Criteria:

* Amblyopia treatment (other than spectacles) in the past month and no more than one month of amblyopia treatment in the past 6 months
* Myopia more than a spherical equivalent of -6.00 D in the amblyopic eye
* Myopia more than a spherical equivalent of -0.50 D in the sound eye
C: Inclusion Criteria:

* Patients must be 3 to less than 7 years old with amblyopia due to strabismus, anisometropia, or both.
* Visual acuity in the amblyopic eye must be between 20/40 and 20/400 inclusive, visual acuity in the sound eye 20/40 or better and inter-eye acuity difference \> 3 logMAR lines.
* Spectacles, if needed, must be worn for at least 16 weeks or until visual acuity documented to be stable.

Exclusion Criteria:

* Prior amblyopia treatment other than spectacles in the past month.
* More than one month of amblyopia treatment in the past 6 months.
D: Inclusion Criteria:

* The child must be aged between 3 years 6 months and 9 years 11 months (upper limit is one day before their 10th birthday on day of consent.)
* Visual acuity difference of at least 0.3 log units, with the amblyopic eye being 0.3 logMAR or worse.
* Must have undergone a minimum of 12 weeks refractive adaptation.
* Those in group one must not have had patching or penalisation at all previously but the other two groups' participants may have had previous occlusion.
* Must not have had previous strabismus surgery (for groups one and two, and for group three, they must start the treatment within 4 weeks of having surgery.
* Must be able to use the I-BiT plus system.

Exclusion Criteria:

* Stimulus deprivation amblyopia.
* Other ocular or neurological disease affecting the visual system (including Down's syndrome, developmental delay,Craniofacial syndrome,Foetal Alcohol Syndrome, and cerebral palsy among other conditions).
* Photosensitive epilepsy.
* Parent, guardian or child not prepared to give consent.

Answer: C