Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomised Comparison of Adjuvant Docetaxel / Cyclophosphamide With Sequential Adjuvant EC / Docetaxel Chemotherapy in Patients With HER2/Neu Negative Early Breast Cancer
Brief Summary: The planned trial compares an anthracycline-free taxane based regimen versus a modern third generation (anthracycline/taxane-based) regimen in HER2/neu non-over expressing tumors. The aim is to define a further anthracycline-free standard and to spare anthracycline toxicity to a patient, who will only have a modest benefit from this compound. Prior to randomization for chemotherapy for all patients with HR positive disease OncotypeDX® will be performed to identify patients who should not receive chemotherapy.

Secondary objectives of this trial will be to compare overall survival and toxicity between the two chemotherapy arms, to evaluate survival in the observation arm and to perform translational research regarding prognostic and predictive factors.


Options:
A: Arm Label: Arm A; Type: ACTIVE_COMPARATOR; Interventions: Drug: Cyclophosphamide, Drug: Doxorubicin, Drug: Paclitaxel, Drug: Carboplatin, Drug: Veliparib | Arm Label: Arm C; Type: PLACEBO_COMPARATOR; Interventions: Drug: Cyclophosphamide, Drug: Placebo, Drug: Doxorubicin, Drug: Paclitaxel | Arm Label: Arm B; Type: PLACEBO_COMPARATOR; Interventions: Drug: Cyclophosphamide, Drug: Doxorubicin, Drug: Paclitaxel, Drug: Carboplatin, Drug: Placebo | Intervention Type: DRUG; Name: Cyclophosphamide; Assigned to Arm(s): Arm A, Arm B, Arm C | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Arm C | Intervention Type: DRUG; Name: Doxorubicin; Assigned to Arm(s): Arm A, Arm B, Arm C | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): Arm A, Arm B, Arm C | Intervention Type: DRUG; Name: Carboplatin; Assigned to Arm(s): Arm A, Arm B | Intervention Type: DRUG; Name: Veliparib; Assigned to Arm(s): Arm A | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Arm B, Arm C
B: Arm Label: Paclitaxel with Carboplatin (PwCb); Type: ACTIVE_COMPARATOR; Interventions: Drug: PwCb, Drug: EC, Procedure: Surgery after neoadjuvant Therapy, Other: Stratification | Arm Label: Paclitaxel with Olaparib (PwO); Type: EXPERIMENTAL; Interventions: Drug: PwO, Drug: EC, Procedure: Surgery after neoadjuvant Therapy, Other: Stratification | Intervention Type: DRUG; Name: PwO; Assigned to Arm(s): Paclitaxel with Olaparib (PwO) | Intervention Type: DRUG; Name: PwCb; Assigned to Arm(s): Paclitaxel with Carboplatin (PwCb) | Intervention Type: DRUG; Name: EC; Assigned to Arm(s): Paclitaxel with Carboplatin (PwCb), Paclitaxel with Olaparib (PwO) | Intervention Type: PROCEDURE; Name: Surgery after neoadjuvant Therapy; Assigned to Arm(s): Paclitaxel with Carboplatin (PwCb), Paclitaxel with Olaparib (PwO) | Intervention Type: OTHER; Name: Stratification; Assigned to Arm(s): Paclitaxel with Carboplatin (PwCb), Paclitaxel with Olaparib (PwO)
C: Arm Label: T-DM1; Type: EXPERIMENTAL; Interventions: Drug: T-DM1 | Arm Label: T-DM1 + endocrine therapy; Type: EXPERIMENTAL; Interventions: Drug: T-DM1 | Arm Label: Trastuzumab + endocrine therapy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Trastuzumab | Intervention Type: DRUG; Name: T-DM1; Assigned to Arm(s): T-DM1, T-DM1 + endocrine therapy | Intervention Type: DRUG; Name: Trastuzumab; Assigned to Arm(s): Trastuzumab + endocrine therapy
D: Arm Label: Epirubicin and Cyclophosphamid followed by Docetaxel; Type: ACTIVE_COMPARATOR; Interventions: Drug: Epirubicin, Drug: Cyclophosphamide, Drug: Docetaxel | Arm Label: Combination of Docetaxel and Cyclophosphamid; Type: EXPERIMENTAL; Interventions: Drug: Cyclophosphamide, Drug: Docetaxel | Intervention Type: DRUG; Name: Epirubicin; Assigned to Arm(s): Epirubicin and Cyclophosphamid followed by Docetaxel | Intervention Type: DRUG; Name: Cyclophosphamide; Assigned to Arm(s): Epirubicin and Cyclophosphamid followed by Docetaxel | Intervention Type: DRUG; Name: Docetaxel; Assigned to Arm(s): Epirubicin and Cyclophosphamid followed by Docetaxel | Intervention Type: DRUG; Name: Cyclophosphamide; Assigned to Arm(s): Combination of Docetaxel and Cyclophosphamid | Intervention Type: DRUG; Name: Docetaxel; Assigned to Arm(s): Combination of Docetaxel and Cyclophosphamid

Answer: D