Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Randomized Control Trial of Surgical Masks vs N95 Respirators to Prevent Influenza in Health Care Workers
Brief Summary: The goal of this study is to compare the efficacy of the surgical mask to the N95 respirator in protecting nurses from influenza in the hospital setting. The investigators propose a non-inferiority randomized controlled trial whereby nurses are randomized to either a surgical mask or an N95 respirator when caring for patients with febrile respiratory illness during the influenza season. The hypothesis is that the surgical mask offers similar protection against influenza to that of the N95. The specific objective of the study is to assess whether the rates of influenza (laboratory-confirmed by PCR and HAI assay), as well as secondary outcomes (influenza-like illness, work-related absenteeism, physician visits for respiratory illness, and lower respiratory infection), are similar among nurses using a surgical mask compared to those using an N95 respirator.


Options:
A: Inclusion Criteria:

* influenza like illness symptoms
* positive rapid test for influenza
* inclusion within 48h of symptom onset
* inclusion of at least 3 members of a household (including index case)

Exclusion Criteria:

* severe illness
* other cases of similar symptoms within 14 days before onset of symptoms in index patient
* severe asthma or COPD
* pregnancy of index
B: Inclusion Criteria:

* Nurses who work in emergency departments and medical units
* Nurses expected to work full time (defined as \> 37 hours per week)

Exclusion Criteria:

* Nurses who were not fit tested
* Nurses who could not pass a fit test
C: Inclusion Criteria:

* Health care workers who provide direct care to patients with suspected or confirmed COVID-19 in specialized COVID-19 units and in emergency departments, medical units, pediatric units, and long-term care facilities
* Health care workers are required to spend 60% or more of their time doing clinical work when enrolled.

Exclusion Criteria:

* Unable to pass or do not have a valid fit test within the past 24 months
* One or more high-risk comorbidities for COVID-19 (hypertension, cardiac disease, pulmonary disease, chronic kidney disease, diabetes, chronic liver disease, actively treated cancer, or immunosuppression due to illness or medications)
* Previous laboratory confirmed clinical diagnosis of COVID-19 at the time of
* Received 1 or more doses of a COVID-19 vaccine with greater than 50% efficacy for the circulating strain (for example, mRNA or vector-based COVID-19 vaccine against the original SARS-CoV-2 strain).
* working in intensive care units.
D: Inclusion Criteria:

* aged 1 month to 18 years
* needing MV for at least 48 hours
* PICU patients

Exclusion Criteria:

* not consenting to participate in the study
* known hypersensitivity to CHX
* presence of tracheotomy,
* undergoing MV for less than 48 hours
* having received MV for more than 24 hours prior to PICU admission
* readmission to PICU
* suspected or diagnosed immunodeficiency
* history of malignant disease(active or at remission),
* being diagnosed with oral mucositis or periodontal disease
* chronic pulmonary and/or cardiac diseases
* having severe oral/facial trauma,
* use of immunosuppressive drugs (such as corticosteroids).

Answer: B