Please select the eligibility criteria that correspond to the clinical trial below.
Title: Xenogenous Collagen Matrix Graft Associated or Not With Enamel Matrix Derivative Proteins in the Treatment of Gingival Recession Class I and II of Miller: Randomized Controlled Clinical Study
Brief Summary: The purpose of this study is to evaluate the reduction of gingival recession of single Miller Class I and II defects treated by coronally advanced flap with subepithelial porcine collagen matrix graft and / or enamel matrix proteins.


Options:
A: Inclusion Criteria:

* Age ≥ 18 years.
* Presence of at least one Class I or II Miller gingival recession ≥ 2.5 mm in maxillary canines or premolars with identifiable cementum-enamel junction (CEJ) and without deep non-carious cervical lesions (\< 0.5 mm): A +(Pini-Prato et al. 2010).
* Aesthetic complaint and/or presence of dentin hypersensitivity to air stimulus.
* Full-mouth visible plaque index ≤ 20% (Ainamo \& Bay 1975).
* Full-mouth sulcus bleeding index ≤ 20% (Mühlemann \& Son 1971).

Exclusion Criteria:

* Smoking.
* Pregnancy.
* Presence of systemic disorders (diabetes, hypertension, heart disease or any other condition that could contraindicate periodontal surgery).
* Use of medications (immunosuppressants, phenytoin or anything else that might affect mucosal healing and repair).
* Previous periodontal surgery in the area.
B: Inclusion Criteria:

* Patients presenting Miller class I or II gingival recession in the maxillary canines or premolars
* Visible cemento-enamel junction (CEJ) with pulp vitality;
* Patients presenting no signs of active periodontal disease and full-mouth plaque and bleeding score ≤20%;
* Patients older than 18 years old; probing depth ˂3 mm in the included teeth;
* Patients who agreed to participate and signed an informed consent form.

Exclusion Criteria:

* Patients presenting systemic problems that would contraindicate the surgical procedure;
* Patients taking medications known to interfere with the wound healing process or that contraindicate the surgical procedure;
* Smokers or pregnant women;
* Patients who underwent periodontal surgery in the area of interest;
* Patients with orthodontic therapy in progress.
C: Inclusion Criteria:

* Recession defects are Miller's class I or II and do not vary more or equal than 3 mm
* Main complaint aesthetic issues or dentine hypersensitivity
* The patient must be a candidate for bilateral root coverage procedure
* Patient shows sufficient plaque control (FMPS \< 20%)
* The patient is able to comply with the study-related procedures such as exercising good oral hygiene and attending all follow-up procedures
* The patient is able to fully understand the nature of the proposed surgery and is able to provide a signed informed consent

Exclusion Criteria:

* Smokers
* Systemic diseases
* Pregnants or lactating
* Periodontal disease
* General contraindications for dental and/or surgical treatment are present
* The patient has a history of malignancy, radiotherapy, or chemotherapy for malignancy within the past five years
* The patient is taking medications or having treatments which have an effect on mucosal healing in general (e.g. steroids, large doses of anti-inflammatory drugs)
D: Inclusion Criteria:

* The patient (male or female) must be 18 years or older
* The patient must be a candidate for bilateral root coverage procedure
* Recession defects are Miller Class I-II and do not vary more than 2 mm.
* At least one mm keratinized tissue is present.
* Patient shows sufficient plaque control (FMPS \< 20%).
* If patient is of child-bearing potential, the patient confirms not to be pregnant and agrees to take contraception for at least 6 months after surgery.
* The patient is able to comply with the study-related procedures such as exercising good oral hygiene and attending all follow-up procedures
* The patient is able to fully understand the nature of the proposed surgery and is able to provide a signed informed consent.

Exclusion Criteria:

* Patient is a heavy smoker (\> 10 cigarettes per day)
* Patient is an insulin dependent diabetic
* General contraindications for dental and/or surgical treatment are present.
* The patient has a history of malignancy, radiotherapy, or chemotherapy for malignancy within the past five years.
* The patient is pregnant or nursing
* The patient is taking medications or having treatments which have an effect on mucosal healing in general (e.g. steroids, large doses of anti-inflammatory drugs).
* The patient has a disease, which affects connective tissue metabolism (e.g. collagenases).
* The patient is allergic to collagen.
* Patients have participated in a clinical trial within the last six months.

Answer: A