Please select the eligibility criteria that correspond to the clinical trial below.
Title: Procalcitonin and Lung Ultrasonography Point-of-care Testing to Decide on Antibiotic Prescription in Patients With Lower Respiratory Tract Infection at Primary Care Level: Pragmatic Cluster Randomized Trial
Brief Summary: The study is randomized clustered pragmatic trial whose objective is to decrease unnecessary antibiotic prescription in adult patients with lower respiratory tract infection managed at primary care level in Switzerland, using a simple algorithm based on 2 point of care test results


Options:
A: Inclusion Criteria:

* Ontario primary care physicians
* Prescribe more antibiotics by volume than 75% of Ontario primary care physicians
* A College of Physicians and Surgeons of Ontario number in 2017-2018

Exclusion Criteria:

* None
B: Inclusion Criteria:

* seen for strep or pneumonia visit at participating site

Exclusion Criteria:

* none
C: All patients presenting to a participating GP's office for a consultation for an acute respiratory infection (ARI) will be screened for inclusion in the study

Inclusion Criteria:

* Informed Consent as documented by signature (Informed Consent Form)
* Patients aged 18 years or more
* No antibiotics prescribed for the current episode
* Acute cough of up to 21 days duration and at least one of the following symptom or sign:
* History of fever for more than 4 days
* dyspnoea
* tachypnoea (≥ 22 cycles per minutes)
* abnormal focal finding during auscultation

Exclusion Criteria:

* Previous prescription of antibiotics for the current episode
* Working diagnosis of acute sinusitis or a non-infective disorder
* Cystic fibrosis
* Previous episode of chronic obstructive pulmonary disease exacerbation treated with antibiotics during the last 6 months
* Known pregnancy
* Severe immunodeficiency (untreated HIV infection with CD4 count \< 200 cells/mm3, solid organ transplant receiver, neutropenia, treatment with corticosteroids with dose equivalent to 20 mg prednisone/day for \> 28
* Admission of the patient
* GP not available for performing study
* Patient unable to provide informed consent
D: Inclusion Criteria:

* Patients aged ≥1 year presenting to selected primary healthcare centres
* Tympanic temperature \>37.5°c or history of fever ≤ 14 days.

Exclusion Criteria:

* Patients that in view of the study nurse are in need of emergency referral to a higher-level facility, as indicated by either 1) impaired consciousness or 2) inability to take oral medication.
* In sites that routinely test for malaria, patients with a positive malaria rapid diagnostic test or microscopy will be excluded
* The main complaint is a trauma and/or injury
* Suspicion of tuberculosis (any medical history and/or physical examination suggesting tuberculosis)
* Suspicion of Urinary Tract Infections (any medical history and/or physical examination suggesting urinary tract infections)
* Suspicion of local skin/dental abscess (any medical history and/or physical examination suggesting a local skin/dental abscess
* Any presenting symptom present for more than 14 days
* Bleeding, including otorrhagia, haematemesis, haemoptysis, haemorrhagic petechiae, haematuria, bloody diarrhoea.
* Not able to comply with the follow-up at Day 5 (+ / - 1 day).

Answer: C