Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: The ATOMIC Study: A Multicenter, Open-label, Randomized, Duration Finding Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Following Oral Administration of PSI-7977 in Combination With Pegylated Interferon and Ribavirin in Treatment-Naive Patients With Chronic HCV Infection Genotype 1,4, 5, or 6
Brief Summary: The purpose of this study is to assess the safety, tolerability, and efficacy of sofosbuvir (GS-7977; PSI-7977) administered in combination with pegylated interferon and ribavirin (PEG/RBV) in treatment-naive patients with HCV genotypes 1,4,5,6, or indeterminate genotype.


Options:
A: Arm Label: Group 1:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(75mg); Type: EXPERIMENTAL; Interventions: Drug: BMS-650032, Drug: BMS-790052, Drug: BMS-791325 | Arm Label: Group 2:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(75mg); Type: EXPERIMENTAL; Interventions: Drug: BMS-650032, Drug: BMS-790052, Drug: BMS-791325 | Arm Label: Group 3:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(150mg); Type: EXPERIMENTAL; Interventions: Drug: BMS-650032, Drug: BMS-790052, Drug: BMS-791325 | Arm Label: Group 4:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(150mg); Type: EXPERIMENTAL; Interventions: Drug: BMS-650032, Drug: BMS-790052, Drug: BMS-791325 | Arm Label: Group 5:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg); Type: EXPERIMENTAL; Interventions: Drug: BMS-650032, Drug: BMS-790052, Drug: BMS-791325 | Arm Label: Group 6:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg); Type: EXPERIMENTAL; Interventions: Drug: BMS-650032, Drug: BMS-790052, Drug: BMS-791325 | Arm Label: Group 7:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg); Type: EXPERIMENTAL; Interventions: Drug: BMS-650032, Drug: BMS-790052, Drug: BMS-791325 | Arm Label: Group 8:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg); Type: EXPERIMENTAL; Interventions: Drug: BMS-650032, Drug: BMS-790052, Drug: BMS-791325 | Arm Label: Group 9:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg); Type: EXPERIMENTAL; Interventions: Drug: BMS-650032, Drug: BMS-790052, Drug: BMS-791325 | Arm Label: Group10:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg); Type: EXPERIMENTAL; Interventions: Drug: BMS-650032, Drug: BMS-790052, Drug: BMS-791325 | Arm Label: Group11:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg); Type: EXPERIMENTAL; Interventions: Drug: BMS-650032, Drug: BMS-790052, Drug: BMS-791325 | Arm Label: Group12:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg); Type: EXPERIMENTAL; Interventions: Drug: BMS-650032, Drug: BMS-790052, Drug: BMS-791325 | Arm Label: Grp13:BMS-650032(200mg)+BMS-790052(30mg)+BMS-791325(75mg)+RBV; Type: EXPERIMENTAL; Interventions: Drug: BMS-650032, Drug: BMS-790052, Drug: BMS-791325, Drug: Ribavirin | Intervention Type: DRUG; Name: BMS-650032; Assigned to Arm(s): Group 1:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(75mg), Group 2:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(75mg), Group 3:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(150mg), Group 4:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(150mg), Group 5:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg), Group 6:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg), Group 7:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg), Group 8:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg), Group 9:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg), Group10:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg), Group11:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg), Group12:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg), Grp13:BMS-650032(200mg)+BMS-790052(30mg)+BMS-791325(75mg)+RBV | Intervention Type: DRUG; Name: BMS-790052; Assigned to Arm(s): Group 1:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(75mg), Group 2:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(75mg), Group 3:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(150mg), Group 4:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(150mg), Group 5:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg), Group 6:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg), Group 7:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg), Group 8:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg), Group 9:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg), Group10:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg), Group11:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg), Group12:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg), Grp13:BMS-650032(200mg)+BMS-790052(30mg)+BMS-791325(75mg)+RBV | Intervention Type: DRUG; Name: BMS-791325; Assigned to Arm(s): Group 1:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(75mg), Group 2:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(75mg), Group 3:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(150mg), Group 4:BMS-650032(200 mg)+BMS-790052(60 mg)+BMS-791325(150mg), Group 5:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg), Group 6:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg), Group 7:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg), Group 8:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg), Group 9:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg), Group10:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg), Group11:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(75mg), Group12:BMS-650032(200 mg)+BMS-790052(30 mg)+BMS-791325(150mg), Grp13:BMS-650032(200mg)+BMS-790052(30mg)+BMS-791325(75mg)+RBV | Intervention Type: DRUG; Name: Ribavirin; Assigned to Arm(s): Grp13:BMS-650032(200mg)+BMS-790052(30mg)+BMS-791325(75mg)+RBV
B: Arm Label: SOF+PEG+RBV 12 weeks; Type: EXPERIMENTAL; Interventions: Drug: Sofosbuvir, Drug: RBV, Drug: PEG | Arm Label: SOF+PEG+RBV 24 weeks; Type: EXPERIMENTAL; Interventions: Drug: Sofosbuvir, Drug: RBV, Drug: PEG | Arm Label: SOF+PEG+RBV 12 week/Rerandomization Group; Type: EXPERIMENTAL; Interventions: Drug: Sofosbuvir, Drug: RBV, Drug: PEG | Intervention Type: DRUG; Name: Sofosbuvir; Assigned to Arm(s): SOF+PEG+RBV 12 week/Rerandomization Group, SOF+PEG+RBV 12 weeks, SOF+PEG+RBV 24 weeks | Intervention Type: DRUG; Name: RBV; Assigned to Arm(s): SOF+PEG+RBV 12 week/Rerandomization Group, SOF+PEG+RBV 12 weeks, SOF+PEG+RBV 24 weeks | Intervention Type: DRUG; Name: PEG; Assigned to Arm(s): SOF+PEG+RBV 12 week/Rerandomization Group, SOF+PEG+RBV 12 weeks, SOF+PEG+RBV 24 weeks
C: Arm Label: T12PR24 (eRVR+); Type: EXPERIMENTAL; Interventions: Drug: telaprevir, Drug: ribavirin, Biological: peginterferon alfa-2a | Arm Label: T12PR48 (eRVR+); Type: EXPERIMENTAL; Interventions: Drug: telaprevir, Drug: ribavirin, Biological: peginterferon alfa-2a | Arm Label: T12PR48 (eRVR-); Type: EXPERIMENTAL; Interventions: Drug: telaprevir, Drug: ribavirin, Biological: peginterferon alfa-2a | Arm Label: Other; Type: EXPERIMENTAL; Interventions: Drug: telaprevir, Drug: ribavirin, Biological: peginterferon alfa-2a | Intervention Type: DRUG; Name: telaprevir; Assigned to Arm(s): Other, T12PR24 (eRVR+), T12PR48 (eRVR+), T12PR48 (eRVR-) | Intervention Type: DRUG; Name: ribavirin; Assigned to Arm(s): Other, T12PR24 (eRVR+), T12PR48 (eRVR+), T12PR48 (eRVR-) | Intervention Type: BIOLOGICAL; Name: peginterferon alfa-2a; Assigned to Arm(s): Other, T12PR24 (eRVR+), T12PR48 (eRVR+), T12PR48 (eRVR-)
D: Arm Label: Sofosbuvir+RBV; Type: EXPERIMENTAL; Interventions: Drug: Sofosbuvir, Drug: RBV | Arm Label: PEG+RBV; Type: ACTIVE_COMPARATOR; Interventions: Drug: PEG, Drug: RBV | Intervention Type: DRUG; Name: Sofosbuvir; Assigned to Arm(s): Sofosbuvir+RBV | Intervention Type: DRUG; Name: PEG; Assigned to Arm(s): PEG+RBV | Intervention Type: DRUG; Name: RBV; Assigned to Arm(s): PEG+RBV, Sofosbuvir+RBV

Answer: B