Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Plasma Exchange and Glucocorticoid Dosing in the Treatment of Anti-neutrophil Cytoplasm Antibody Associated Vasculitis: an International Randomized Controlled Trial
Brief Summary: The purpose of this study is to determine whether plasma exchange as well as immunosuppressive therapy are effective in reducing death and end-stage renal disease (ESRD). The trial will also study whether a reduced cumulative dosing regimen of glucocorticoids is as effective as a standard disease regimen.

The FDA-OOPD is one of the funding sources for this study.


Options:
A: Arm Label: Placebo plus azathioprine; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo, Drug: Azathioprine | Arm Label: Belimumab 10 mg/kg plus azathioprine; Type: EXPERIMENTAL; Interventions: Biological: Belimumab 10 mg/kg, Drug: Azathioprine | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Placebo plus azathioprine | Intervention Type: BIOLOGICAL; Name: Belimumab 10 mg/kg; Assigned to Arm(s): Belimumab 10 mg/kg plus azathioprine | Intervention Type: DRUG; Name: Azathioprine; Assigned to Arm(s): Belimumab 10 mg/kg plus azathioprine, Placebo plus azathioprine
B: Arm Label: A; Type: OTHER; Interventions: Drug: prednisone, methylprednisolone,cyclophosphamides, Drug: Mycophenolate mofetil,methotrexate | Arm Label: B; Type: EXPERIMENTAL; Interventions: Drug: Cyclophosphamide, Azathioprine,prednisone,methylprednisolone, Drug: Mycophenolate mofetil,methotrexate | Intervention Type: DRUG; Name: prednisone, methylprednisolone,cyclophosphamides; Assigned to Arm(s): A | Intervention Type: DRUG; Name: Cyclophosphamide, Azathioprine,prednisone,methylprednisolone; Assigned to Arm(s): B | Intervention Type: DRUG; Name: Mycophenolate mofetil,methotrexate; Assigned to Arm(s): A, B
C: Arm Label: Plasma Exchange with Standard Glucocorticoids; Type: EXPERIMENTAL; Interventions: Procedure: Plasma Exchange, Drug: Glucocorticoids [Standard Dose] | Arm Label: No Plasma Exchange with Standard Glucocorticoids; Type: ACTIVE_COMPARATOR; Interventions: Other: No Plasma Exchange, Drug: Glucocorticoids [Standard Dose] | Arm Label: Plasma Exchange with Reduced-Dose Glucocorticoids; Type: EXPERIMENTAL; Interventions: Procedure: Plasma Exchange, Drug: Glucocorticoids [Reduced Dose] | Arm Label: No Plasma Exchange with Reduced-Dose Glucocorticoids; Type: ACTIVE_COMPARATOR; Interventions: Other: No Plasma Exchange, Drug: Glucocorticoids [Reduced Dose] | Intervention Type: PROCEDURE; Name: Plasma Exchange; Assigned to Arm(s): Plasma Exchange with Reduced-Dose Glucocorticoids, Plasma Exchange with Standard Glucocorticoids | Intervention Type: OTHER; Name: No Plasma Exchange; Assigned to Arm(s): No Plasma Exchange with Reduced-Dose Glucocorticoids, No Plasma Exchange with Standard Glucocorticoids | Intervention Type: DRUG; Name: Glucocorticoids [Standard Dose]; Assigned to Arm(s): No Plasma Exchange with Standard Glucocorticoids, Plasma Exchange with Standard Glucocorticoids | Intervention Type: DRUG; Name: Glucocorticoids [Reduced Dose]; Assigned to Arm(s): No Plasma Exchange with Reduced-Dose Glucocorticoids, Plasma Exchange with Reduced-Dose Glucocorticoids
D: Arm Label: Rituximab Maintenance; Type: EXPERIMENTAL; Interventions: Biological: Rituximab | Arm Label: Azathioprine Maintenance; Type: ACTIVE_COMPARATOR; Interventions: Drug: Azathioprine | Intervention Type: BIOLOGICAL; Name: Rituximab; Assigned to Arm(s): Rituximab Maintenance | Intervention Type: DRUG; Name: Azathioprine; Assigned to Arm(s): Azathioprine Maintenance

Answer: C