Please select the eligibility criteria that correspond to the clinical trial below.
Title: Dose-Response of Gonadal Steroids and Bone Turnover in Older Men
Brief Summary: The purpose of this study is to determine the levels of testosterone and/or estradiol at which changes in bone turnover, body composition, strength, sexual function etc. begin to occur in older men. This information may help determine when to intervene with hormone replacement therapy in aging men.


Options:
A: Inclusion Criteria:

* Healthy men age 60 to 75

Exclusion Criteria:

* History of significant cardiac, renal, pulmonary, hepatic, benign prostatic hyperplasia, or malignant disease, current alcohol or illicit drug abuse, or major psychiatric disorders.
* Current diagnoses of disorders known to affect bone metabolism including hyperthyroidism, hyperparathyroidism, osteomalacia, or Paget's disease.
* Current use of medications known to affect bone metabolism including estrogens, androgens, anti-estrogens, bisphosphonates, calcitonin, fluoride, oral or inhaled glucocorticoids, suppressive doses of thyroxine, lithium, pharmacological doses of vitamin D (greater than 2000 IU/day), or anti-convulsants.
* Cognitive or intellectual impairment that precludes complete understanding of the study protocol.
* History of deep vein thrombosis, pulmonary embolism, or clotting disorders.
* Serum 25-hydroxyvitamin D \< 15 ng/mL
* Serum parathyroid hormone (PTH) \< 10 or \> 65 pg/mL
* Serum thyroid stimulating hormone (TSH) \< 0.5 or \> 5.0 U/L
* Serum calcium \> 10.6 mg/dL
* Serum creatinine \> 2 mg/dL
* Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) \> 2x the upper limit of normal
* Serum bilirubin \> 2 mg/dL
* Serum alkaline phosphatase \> 150 U/L
* Plasma hemoglobin \< 11 gm/dL
* Hematocrit \> 50
* Fracture within the last 6 months.
* Serum testosterone level \< 270 or \> 1070 ng/dL
* Serum prostate specific antigen (PSA) level \> 4 ug/L.
* International Prostate Symptom Score (IPSS) \> 19
* Systolic blood pressure \> 160 or diastolic blood pressure \> 95
* Framingham risk score greater than or equal to 20
* Difficulty walking 2 blocks
B: Inclusion Criteria:

* Men and women between 18 and 80 years of age
* People with abnormal cholesterol levels

Exclusion Criteria:

* People with diabetes
* People whose blood pressure \>160/95 mm Hg, on or off blood pressure medicine
* People who have had frequent chest pain or unstable angina, a heart attack or a heart procedure including stent placement, within the past 3 months
C: Inclusion Criteria:

* clinically defined lacunar syndrome 3 months before inclusion
* small deep infarct on diffusion MRI (Diffusion Weighted Imaging)
* no atherothrombotic, cardio-embolic, or other rarer cause.

Exclusion Criteria:

* patients with past coronary event
* contra-indication for assessment of vasomotor reactivity
* patients being on statin therapy at the time of brain infarction
* contra-indication for statin therapy
* patient still under statin therapy
D: Inclusion Criteria:

* Men and women between 18 and 80 years of age
* People with abnormal fat levels in the blood (low HDL, high TG)

Exclusion Criteria:

* People with diabetes
* People whose blood pressure is greater than 160/95 mm Hg, on or off blood pressure medicine
* People who have had frequent chest pain or unstable angina, a heart attack or a heart procedure, including stent placement, within the past 3 months

Answer: A