Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Sleep and Tolerability of Extended Release Dexmethylphenidate vs. Mixed Amphetamine Salts: A Double Blind, Placebo Controlled Study (SAT STUDY)
Brief Summary: The purpose of this study is to evaluate how children and adolescents with Attention Deficit/ Hyperactivity Disorder (ADHD) respond to treatment with three differing doses of stimulant medications used to treat ADHD, Adderall XR® and Focalin XR®. Another purpose of the study is to evaluate if there are differences in sleep and other side effects, such as changes in mood or loss of appetite, which can occur with stimulant medications. A third purpose is to determine if there are differences in the characteristics of individuals who respond better to either of the medications.

This research is being done because the investigators do not know if one of these two commonly used treatments is better tolerated than the other. Children and adolescents with ADHD often have a hard time sitting still, playing quietly, finishing things they start, paying attention, waiting their turn, and not distracting others. These medications improve these symptoms, but sometimes affect sleep, appetite, or mood.

It is hypothesized that at effective and frequently prescribed doses, Adderall will be associated with insomnia, more stimulant side effects, and decreased tolerability during an acute trial relative to Focalin.


Options:
A: Arm Label: Methylphenidate; Type: ACTIVE_COMPARATOR; Interventions: Drug: Methylphenidate | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Methylphenidate; Assigned to Arm(s): Methylphenidate | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
B: Arm Label: Focalin XR then Adderall XR; Type: EXPERIMENTAL; Interventions: Drug: Dexmethylphenidate, Drug: Mixed Amphetamine Salts, ER, Drug: placebo | Arm Label: Adderall XR then Focalin XR; Type: EXPERIMENTAL; Interventions: Drug: Dexmethylphenidate, Drug: Mixed Amphetamine Salts, ER, Drug: placebo | Intervention Type: DRUG; Name: Dexmethylphenidate; Assigned to Arm(s): Adderall XR then Focalin XR, Focalin XR then Adderall XR | Intervention Type: DRUG; Name: Mixed Amphetamine Salts, ER; Assigned to Arm(s): Adderall XR then Focalin XR, Focalin XR then Adderall XR | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Adderall XR then Focalin XR, Focalin XR then Adderall XR
C: Arm Label: Medication Arm; Type: ACTIVE_COMPARATOR; Interventions: Drug: Vyvanse, Drug: Methylphenidate | Arm Label: Behavioral Parent Training Arm; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Behavioral Parent Training | Intervention Type: DRUG; Name: Vyvanse; Assigned to Arm(s): Medication Arm | Intervention Type: BEHAVIORAL; Name: Behavioral Parent Training; Assigned to Arm(s): Behavioral Parent Training Arm | Intervention Type: DRUG; Name: Methylphenidate; Assigned to Arm(s): Medication Arm
D: Arm Label: Active Treatment; Type: EXPERIMENTAL; Interventions: Drug: PRC-063 oral capsules | Arm Label: Placebo Treatment; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo oral capsules | Intervention Type: DRUG; Name: PRC-063 oral capsules; Assigned to Arm(s): Active Treatment | Intervention Type: DRUG; Name: Placebo oral capsules; Assigned to Arm(s): Placebo Treatment

Answer: B