Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: An International Randomised Controlled Trial to Establish the Effects of Low-dose rtPA and the Effects of Early Intensive Blood Pressure Lowering in Patients With Acute Ischaemic Stroke
Brief Summary: ENCHANTED is an independent, investigator initiated, international collaborative, quasi-factorial randomised controlled trial involving a package of 2 linked comparative randomised treatment arms, which aims to address 4 key questions in patients eligible for thrombolysis in the acute phase of ischaemic stroke. (1) Does low-dose (0.6 mg/kg) intravenous (i.v.) recombinant tissue plasminogen activator (rtPA) provide equivalent benefits compared to standard-dose (0.9 mg/kg) rtPA? (2) Does intensive blood pressure (BP) lowering (130-140 mmHg systolic target) improve outcomes compared to the current guideline recommended level of BP control (180 mmHg systolic target)? (3) Does low-dose (0.6 mg/kg) intravenous (i.v.) recombinant tissue plasminogen activator (rtPA) reduce the risk of symptomatic intracerebral haemorrhage (sICH)? (4) Does the addition of intensive BP lowering to thrombolysis with rtPA reduce the risk of any intracerebral haemorrhage (ICH)?

The rtPA dose arm of the study addressing questions (1) and (3) concluded with a publication of the results in May 2016. The BP intensity arm of the study addressing questions (2) and (4) concluded with a publication of the results in February 2019.


Options:
A: Arm Label: Best medical management.; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Additional intra-arterial treatment.; Type: EXPERIMENTAL; Interventions: Other: Intra-arterial treatment | Intervention Type: OTHER; Name: Intra-arterial treatment; Assigned to Arm(s): Additional intra-arterial treatment.
B: Arm Label: Intensive blood pressure management; Type: EXPERIMENTAL; Interventions: Other: Systolic blood pressure target < 130 mm Hg | Arm Label: Standard blood pressure management; Type: ACTIVE_COMPARATOR; Interventions: Other: Systolic blood pressure target < 185 mm Hg | Intervention Type: OTHER; Name: Systolic blood pressure target < 130 mm Hg; Assigned to Arm(s): Intensive blood pressure management | Intervention Type: OTHER; Name: Systolic blood pressure target < 185 mm Hg; Assigned to Arm(s): Standard blood pressure management
C: Arm Label: Group with endovascular treatment; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Rescue endovascular therapy | Arm Label: Group without endovascular treatment; Type: ACTIVE_COMPARATOR; Interventions: Procedure: No endovascular therapy | Intervention Type: PROCEDURE; Name: Rescue endovascular therapy; Assigned to Arm(s): Group with endovascular treatment | Intervention Type: PROCEDURE; Name: No endovascular therapy; Assigned to Arm(s): Group without endovascular treatment
D: Arm Label: Low-dose rtPA (Recruitment completed in August 2015); Type: EXPERIMENTAL; Interventions: Drug: Low-dose rtPA | Arm Label: Standard-dose rtPA (Recruitment completed in August 2015); Type: ACTIVE_COMPARATOR; Interventions: Drug: Standard-dose rtPA | Arm Label: Early intensive BP lowering; Type: EXPERIMENTAL; Interventions: Other: Intensive blood pressure (BP) lowering | Arm Label: Control / guideline-based BP management; Type: ACTIVE_COMPARATOR; Interventions: Other: BP management policies | Intervention Type: DRUG; Name: Low-dose rtPA; Assigned to Arm(s): Low-dose rtPA (Recruitment completed in August 2015) | Intervention Type: DRUG; Name: Standard-dose rtPA; Assigned to Arm(s): Standard-dose rtPA (Recruitment completed in August 2015) | Intervention Type: OTHER; Name: Intensive blood pressure (BP) lowering; Assigned to Arm(s): Early intensive BP lowering | Intervention Type: OTHER; Name: BP management policies; Assigned to Arm(s): Control / guideline-based BP management

Answer: D