Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A PHASE III, MULTI-CENTER, RANDOMIZED OPEN LABEL STUDY OF VELCADE, MELPHALAN, PREDNISONE AND THALIDOMIDE (V-MPT) Versus VELCADE, MELPHALAN, PREDNISONE (V-MP) IN ELDERLY UNTREATED MULTIPLE MYELOMA PATIENTS
Brief Summary: The proposed study will evaluate whether the combination of VELCADE, Thalidomide , Melphalan and Prednisone (V-MPT), as induction treatment for newly diagnosed elderly MM patients, improves outcomes compared to the combination VELCADE-MP.


Options:
A: Arm Label: Arm I (dexamethasone and lenalidomide); Type: ACTIVE_COMPARATOR; Interventions: Drug: Dexamethasone, Other: Laboratory Biomarker Analysis, Drug: Lenalidomide | Arm Label: Arm II (dexamethasone, lenalidomide, bortezomib); Type: EXPERIMENTAL; Interventions: Drug: Bortezomib, Drug: Dexamethasone, Other: Laboratory Biomarker Analysis, Drug: Lenalidomide | Intervention Type: DRUG; Name: Bortezomib; Assigned to Arm(s): Arm II (dexamethasone, lenalidomide, bortezomib) | Intervention Type: DRUG; Name: Dexamethasone; Assigned to Arm(s): Arm I (dexamethasone and lenalidomide), Arm II (dexamethasone, lenalidomide, bortezomib) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Arm I (dexamethasone and lenalidomide), Arm II (dexamethasone, lenalidomide, bortezomib) | Intervention Type: DRUG; Name: Lenalidomide; Assigned to Arm(s): Arm I (dexamethasone and lenalidomide), Arm II (dexamethasone, lenalidomide, bortezomib)
B: Arm Label: Bortezomib and Dexamethasone (VD); Type: EXPERIMENTAL; Interventions: Drug: Bortezomib, Drug: Dexamethasone | Arm Label: Bortezomib, Thalidomide, and Dexamethasone (VTD); Type: EXPERIMENTAL; Interventions: Drug: Bortezomib, Drug: Dexamethasone, Drug: Thalidomide | Arm Label: Bortezomib, Melphalan and Prednisone (VMP); Type: EXPERIMENTAL; Interventions: Drug: Bortezomib, Drug: Melphalan, Drug: Prednisone | Intervention Type: DRUG; Name: Bortezomib; Assigned to Arm(s): Bortezomib and Dexamethasone (VD), Bortezomib, Melphalan and Prednisone (VMP), Bortezomib, Thalidomide, and Dexamethasone (VTD) | Intervention Type: DRUG; Name: Dexamethasone; Assigned to Arm(s): Bortezomib and Dexamethasone (VD), Bortezomib, Thalidomide, and Dexamethasone (VTD) | Intervention Type: DRUG; Name: Melphalan; Assigned to Arm(s): Bortezomib, Melphalan and Prednisone (VMP) | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): Bortezomib, Melphalan and Prednisone (VMP) | Intervention Type: DRUG; Name: Thalidomide; Assigned to Arm(s): Bortezomib, Thalidomide, and Dexamethasone (VTD)
C: Arm Label: Arm A: VMPT; Type: EXPERIMENTAL; Interventions: Drug: Bortezomib, Melphalan, Prednisone, Thalidomide | Arm Label: VMP; Type: ACTIVE_COMPARATOR; Interventions: Drug: Bortezomib, Melphalan, Prednisone | Intervention Type: DRUG; Name: Bortezomib, Melphalan, Prednisone, Thalidomide; Assigned to Arm(s): Arm A: VMPT | Intervention Type: DRUG; Name: Bortezomib, Melphalan, Prednisone; Assigned to Arm(s): VMP
D: Arm Label: Thalidomide; Type: EXPERIMENTAL; Interventions: Drug: Thalidomide, Drug: Melphalan+Prednisolone | Arm Label: Control; Type: ACTIVE_COMPARATOR; Interventions: Drug: Melphalan+Prednisolone | Intervention Type: DRUG; Name: Thalidomide; Assigned to Arm(s): Thalidomide | Intervention Type: DRUG; Name: Melphalan+Prednisolone; Assigned to Arm(s): Control, Thalidomide

Answer: C