Please select the eligibility criteria that correspond to the clinical trial below.
Title: Effects of Two Hypocaloric Diets on Weight Loss and Inflammatory Markers
Brief Summary: The investigators evaluated whether an energy-restricted protein diet with low glycaemic index carbohydrates and soluble fibers (LC-P-LGI) would be more effective than a conventional diet (LC-CONV) on weight-loss and related metabolic variables.


Options:
A: Inclusion Criteria:

* 18-35 years of age
* Intending to be available for a 24 month intervention
* An active cellular telephone that is capable of receiving text messaging
* A computer and internet connectivity that can be used for the BodyMedia Fit system
* Body mass index (BMI) between 25.0-39.9 kg/m2
* The ability to provide medical clearance to participate in this study from their primary care physician
* The ability to complete the baseline graded exercise test, and clearance from the study physician to participate in this study after reviewing the results from this study

Exclusion Criteria:

* Unable to provide informed consent
* Household member on study staff
* Past or planned (within the next 24 months) weight loss surgery (e.g. gastric bypass, lap band, or liposuction); current participation in a commercial weight loss program (e.g. Weight Watcher's, Jenny Craig); current or planned enrollment in another diet/PA/weight loss intervention study
* Report regular use of systemic steroids, prescription weight loss drugs. "Regular use" is defined as "taking this medication most days of the week for the previous month"
* Current treatment for eating disorder
* Cardiovascular event (heart attack, stroke, episode of heart failure, or revascularization procedure) within the last 6 months
* Current treatment for malignancy (other than non-melanoma skin cancer)
* Currently pregnant or gave birth within the last 6 months, currently lactating or breastfeeding within the last 3 months, actively planning pregnancy within the next 24 months
* Investigator discretion
* Currently taking medication that would affect heart rate or blood pressure responses to exercise (e.g., beta blockers)
* Report losing \>5% of current body weight in the previous 6 months
* Currently treated for psychological issues, or taking psychotropic medications within the previous 6 months
* Report taking medication that could affect metabolism or change body weight
* Current treatment for diabetes mellitus
B: Inclusion Criteria:

* Hispanic children aged 7-14 years with BMI \>= 95th percentile at risk for T2DM and who are otherwise healthy
* Ethnicity will be by self-identification with the Hispanic or Latino cultural group by the subject's parents and both sets of grandparents.
* At risk for T2DM defined as a positive family history of T2DM plus insulin resistance (fasting hyperinsulinemia ≥ 15 uIU/mL) or impaired glucose tolerance (fasting glucose \>110 mg/dl, or 2-hour postglucose challenge \>140 mg/dl).
* Only one child per family will be eligible to participate in the study

Exclusion Criteria:

* pre-existing T2DM
* Cushing syndrome
* untreated hypothyroidism
* pervasive developmental disorder
* severe asthma
* severe untreated depression
* use of medications that promote weight gain or loss
* obesity-associated genetic syndromes (e.g. Prader Willi syndrome)
C: Inclusion Criteria:

* BMI 26 to 35 Kg/m2
* 25 to 60 years old
* non diabetic subjects

Exclusion Criteria:

* SGOT and SGPT \>2.5x the normal
* plasma glucose more than 1.26 g/l
* hepatic or renal or cardiac failure
D: Inclusion Criteria:

Overweight, age 21-50 years,Women must be premenopausal, Normal glucose tolerance, weight stable for at least 6 months with a weight change no greater than 5 lbs.

Exclusion Criteria:

Exclusion criteria were type 1 or type 2 diabetes, polycystic ovarian disease, BMI \<26.5 or weight \>300 pounds, weight change \>5 pounds in last 6 months, regular exercise \>2 hours per week, pregnancy, currently breastfeeding, cholesterol medications, any disorders of glucose or lipid metabolism, use of medication that could affect body composition or glucose metabolism (including oral contraceptives and blood pressure medications), current use of tobacco, use of illegal drugs in last 6 months, history of hypoglycemic episodes, major food allergies or food dislikes, women with inconsistent or absence of monthly menstrual cycles, and a medical history that counter-indicated inclusion in the study.

Answer: C