Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: An Open Label, Randomised, Four-Period Crossover, Single Dose Study in Healthy Volunteers to Evaluate the Pharmacokinetics of FF/UMEC/VI Combination Administered at Dose Levels 100/62.5/25 mcg and 100/125/25 mcg and in Comparison With FF/VI (100/25 mcg) and UMEC/VI (62.5/25 mcg).
Brief Summary: This study will evaluate the pharmacokinetics of FF, UMEC and VI administered from one inhaler (at two different strengths of UMEC (125 and 62.5microgram \[mcg\]) and FF/VI (ICS/LABA) and UMEC/VI (LAMA/LABA).

Subjects will receive each of the four treatments once, separated by a wash-out period of 7-21 days between doses in a four way crossover design. There will be 4 treatment periods in total. During each treatment period, subjects will attend the clinical unit on Day -1 for standard safety assessments in addition to familiarization with the inhaler. Each subject will remain resident in the unit until at least 24 hours after the dose given on Day 1. Following completion of all four treatment periods, a follow up visit will take place 7 to 21 days following the final dose of study medication.


Options:
A: Arm Label: GSK573719/GW642444; Type: EXPERIMENTAL; Interventions: Drug: GSK573719/GW642444 125/25mcg | Arm Label: GSK573719; Type: EXPERIMENTAL; Interventions: Drug: GSK573719 125mcg | Arm Label: GW642444; Type: EXPERIMENTAL; Interventions: Drug: GW642444 25mcg | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo only | Intervention Type: DRUG; Name: GSK573719/GW642444 125/25mcg; Assigned to Arm(s): GSK573719/GW642444 | Intervention Type: DRUG; Name: GSK573719 125mcg; Assigned to Arm(s): GSK573719 | Intervention Type: DRUG; Name: GW642444 25mcg; Assigned to Arm(s): GW642444 | Intervention Type: DRUG; Name: Placebo only; Assigned to Arm(s): Placebo
B: Arm Label: UMEC/VI 125/25 mcg; Type: EXPERIMENTAL; Interventions: Drug: UMEC/VI 125/25 mcg | Arm Label: UMEC/VI 62.5/25 mcg; Type: EXPERIMENTAL; Interventions: Drug: UMEC/VI 62.5/25 mcg | Arm Label: UMEC 125 mcg; Type: EXPERIMENTAL; Interventions: Drug: UMEC 125 mcg | Arm Label: UMEC 62.5 mcg; Type: EXPERIMENTAL; Interventions: Drug: UMEC 62.5 mcg | Arm Label: VI 25 mcg; Type: EXPERIMENTAL; Interventions: Drug: VI 25 mcg | Intervention Type: DRUG; Name: UMEC/VI 125/25 mcg; Assigned to Arm(s): UMEC/VI 125/25 mcg | Intervention Type: DRUG; Name: UMEC/VI 62.5/25 mcg; Assigned to Arm(s): UMEC/VI 62.5/25 mcg | Intervention Type: DRUG; Name: UMEC 125 mcg; Assigned to Arm(s): UMEC 125 mcg | Intervention Type: DRUG; Name: UMEC 62.5 mcg; Assigned to Arm(s): UMEC 62.5 mcg | Intervention Type: DRUG; Name: VI 25 mcg; Assigned to Arm(s): VI 25 mcg
C: Arm Label: Sequence 1; Type: EXPERIMENTAL; Interventions: Drug: FF 400 mcg, Drug: UMEC 500 mcg, Drug: UMEC 250 mcg, Drug: VI 100 mcg | Arm Label: Sequence 2; Type: EXPERIMENTAL; Interventions: Drug: FF 400 mcg, Drug: UMEC 500 mcg, Drug: UMEC 250 mcg, Drug: VI 100 mcg | Arm Label: Sequence 3; Type: EXPERIMENTAL; Interventions: Drug: FF 400 mcg, Drug: UMEC 500 mcg, Drug: UMEC 250 mcg, Drug: VI 100 mcg | Arm Label: Sequence 4; Type: EXPERIMENTAL; Interventions: Drug: FF 400 mcg, Drug: UMEC 500 mcg, Drug: UMEC 250 mcg, Drug: VI 100 mcg | Intervention Type: DRUG; Name: FF 400 mcg; Assigned to Arm(s): Sequence 1, Sequence 2, Sequence 3, Sequence 4 | Intervention Type: DRUG; Name: UMEC 500 mcg; Assigned to Arm(s): Sequence 1, Sequence 2, Sequence 3, Sequence 4 | Intervention Type: DRUG; Name: UMEC 250 mcg; Assigned to Arm(s): Sequence 1, Sequence 2, Sequence 3, Sequence 4 | Intervention Type: DRUG; Name: VI 100 mcg; Assigned to Arm(s): Sequence 1, Sequence 2, Sequence 3, Sequence 4
D: Arm Label: Active; Type: EXPERIMENTAL; Interventions: Drug: 100mcg | Arm Label: Active 2; Type: EXPERIMENTAL; Interventions: Drug: 500mcg | Arm Label: Active 3; Type: EXPERIMENTAL; Interventions: Drug: 1000mcg | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: 100mcg; Assigned to Arm(s): Active | Intervention Type: DRUG; Name: 500mcg; Assigned to Arm(s): Active 2 | Intervention Type: DRUG; Name: 1000mcg; Assigned to Arm(s): Active 3 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo

Answer: C