Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase IIB , Randomized, Multi-Center, Double-Blind, Dose-Ranging, Placebo/Active Controlled Study to Evaluate the Efficacy and Safety of BMS-945429 Subcutaneous Injection With or Without Methotrexate in Subjects With Moderate to Severe Rheumatoid Arthritis With Inadequate Response to Methotrexate.
Brief Summary: The purpose of this study is to determine the effective dose of BMS-945429 in subjects with inadequate response to Methotrexate in the treatment of moderate to severe Rheumatoid Arthritis.


Options:
A: Arm Label: Arm 1; Type: PLACEBO_COMPARATOR; Interventions: Drug: BMS-945429 Placebo, Biological: BMS-945429, Drug: Methotrexate, Drug: Adalimumab Placebo | Arm Label: Arm 2; Type: EXPERIMENTAL; Interventions: Biological: BMS-945429, Drug: Methotrexate, Drug: Adalimumab Placebo | Arm Label: Arm 3; Type: EXPERIMENTAL; Interventions: Biological: BMS-945429, Drug: Methotrexate, Drug: Adalimumab Placebo | Arm Label: Arm 4; Type: EXPERIMENTAL; Interventions: Biological: BMS-945429, Drug: Methotrexate, Drug: Adalimumab Placebo | Arm Label: Arm 5; Type: EXPERIMENTAL; Interventions: Biological: BMS-945429, Drug: Methotrexate Placebo, Drug: Methotrexate, Drug: Adalimumab Placebo | Arm Label: Arm 6; Type: EXPERIMENTAL; Interventions: Biological: BMS-945429, Drug: Methotrexate Placebo, Drug: Methotrexate, Drug: Adalimumab Placebo | Arm Label: Arm 7; Type: ACTIVE_COMPARATOR; Interventions: Drug: Methotrexate, Drug: Adalimumab | Intervention Type: DRUG; Name: BMS-945429 Placebo; Assigned to Arm(s): Arm 1 | Intervention Type: BIOLOGICAL; Name: BMS-945429; Assigned to Arm(s): Arm 4 | Intervention Type: BIOLOGICAL; Name: BMS-945429; Assigned to Arm(s): Arm 3, Arm 6 | Intervention Type: BIOLOGICAL; Name: BMS-945429; Assigned to Arm(s): Arm 1, Arm 4 | Intervention Type: BIOLOGICAL; Name: BMS-945429; Assigned to Arm(s): Arm 2, Arm 5 | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): Arm 1 | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): Arm 2, Arm 3, Arm 4, Arm 7 | Intervention Type: DRUG; Name: Methotrexate Placebo; Assigned to Arm(s): Arm 5, Arm 6 | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): Arm 5, Arm 6 | Intervention Type: DRUG; Name: Adalimumab Placebo; Assigned to Arm(s): Arm 1, Arm 2, Arm 3, Arm 4, Arm 5, Arm 6 | Intervention Type: DRUG; Name: Adalimumab; Assigned to Arm(s): Arm 7
B: Arm Label: Group 1: Placebo + Methotrexate; Type: PLACEBO_COMPARATOR; Interventions: Drug: Methotrexate, Drug: Placebo injection | Arm Label: Group 2: Golimumab 100 mg + Placebo; Type: EXPERIMENTAL; Interventions: Drug: Golimumab 100 mg, Drug: Placebo capsules | Arm Label: Group 3: Golimumab 50 mg + Methotrexate; Type: EXPERIMENTAL; Interventions: Drug: Golimumab 50 mg, Drug: Methotrexate | Arm Label: Group 4: Golimumab 100 mg + Methotrexate; Type: EXPERIMENTAL; Interventions: Drug: Golimumab 100 mg, Drug: Methotrexate | Intervention Type: DRUG; Name: Golimumab 100 mg; Assigned to Arm(s): Group 2: Golimumab 100 mg + Placebo, Group 4: Golimumab 100 mg + Methotrexate | Intervention Type: DRUG; Name: Golimumab 50 mg; Assigned to Arm(s): Group 3: Golimumab 50 mg + Methotrexate | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): Group 1: Placebo + Methotrexate, Group 3: Golimumab 50 mg + Methotrexate, Group 4: Golimumab 100 mg + Methotrexate | Intervention Type: DRUG; Name: Placebo injection; Assigned to Arm(s): Group 1: Placebo + Methotrexate | Intervention Type: DRUG; Name: Placebo capsules; Assigned to Arm(s): Group 2: Golimumab 100 mg + Placebo
C: Arm Label: Tocilizumab 4 mg/kg + Methotrexate; Type: EXPERIMENTAL; Interventions: Drug: tocilizumab [RoActemra/Actemra], Drug: Methotrexate | Arm Label: Tocilizumab 8 mg/kg + Methotrexate; Type: EXPERIMENTAL; Interventions: Drug: tocilizumab [RoActemra/Actemra], Drug: Methotrexate | Arm Label: Placebo + Methotrexate; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Drug: Methotrexate | Intervention Type: DRUG; Name: tocilizumab [RoActemra/Actemra]; Assigned to Arm(s): Tocilizumab 4 mg/kg + Methotrexate, Tocilizumab 8 mg/kg + Methotrexate | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo + Methotrexate | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): Placebo + Methotrexate, Tocilizumab 4 mg/kg + Methotrexate, Tocilizumab 8 mg/kg + Methotrexate
D: Arm Label: Infliximab; Type: EXPERIMENTAL; Interventions: Drug: Infliximab | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Infliximab; Assigned to Arm(s): Infliximab | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo

Answer: A