Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Histological Evaluation of Healing Following Ridge Preservation Using a Combined Cortical/Cancellous Mineralized Freeze-Dried Bone Allograft
Brief Summary: The study is a 3-arm, parallel-design, randomized, prospective clinical trial.designed to examine histologic wound healing following ridge preservation using cortical bone allograft, cancellous bone allograft, or a combination of both cortical and cancellous bone allograft. This entire protocol involves procedures that are standard care. All materials are FDA-approved materials being used in an FDA-approved manner. The test group subjects will have extraction sockets grafted with a combination of 50% cortical/50% cancellous FDBA. This test group will be compared to two active control groups - one using 100% cortical FDBA and the other using 100% cancellous FDBA. The null hypothesis is that there will be no significant difference in formation of new vital bone between treatment groups (primary outcome).

Each subject will provide a single non-molar tooth site for study treatment. After tooth extraction, the graft material will be placed and covered by a non-resorbable membrane. Following 18-20 weeks of healing, the dental implant will be place, at which time a core of bone will be removed from the site as part of the preparation for the implant. The core biopsy will then be evaluated for the primary histologic outcome of % vital bone formation and secondary histologic outcome of % residual graft material.


Options:
A: Arm Label: natural healing; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Alveolar Ridge Preservation; Type: EXPERIMENTAL; Interventions: Device: Alveolar Ridge Preservation | Arm Label: Immediate Implant + Alveolar Ridge Preservation; Type: EXPERIMENTAL; Interventions: Device: Alveolar Ridge Preservation | Intervention Type: DEVICE; Name: Alveolar Ridge Preservation; Assigned to Arm(s): Alveolar Ridge Preservation, Immediate Implant + Alveolar Ridge Preservation
B: Arm Label: PUROS (Non-Freeze-Dried bone allograft); Type: EXPERIMENTAL; Interventions: Device: PUROS (Ridge Preservation bone grafting surgery) | Arm Label: FDBA (Freeze-Dried bone allograft); Type: ACTIVE_COMPARATOR; Interventions: Device: FDBA (Ridge Preservation bone grafting surgery) | Intervention Type: DEVICE; Name: PUROS (Ridge Preservation bone grafting surgery); Assigned to Arm(s): PUROS (Non-Freeze-Dried bone allograft) | Intervention Type: DEVICE; Name: FDBA (Ridge Preservation bone grafting surgery); Assigned to Arm(s): FDBA (Freeze-Dried bone allograft)
C: Arm Label: Combination 50% cortical/50% cancellous FDBA; Type: EXPERIMENTAL; Interventions: Device: 50% cortical/50% cancellous FDBA | Arm Label: 100% cortical FDBA; Type: ACTIVE_COMPARATOR; Interventions: Device: 100% cortical FDBA | Arm Label: 100% cancellous FDBA; Type: ACTIVE_COMPARATOR; Interventions: Device: 100% cancellous FDBA | Intervention Type: DEVICE; Name: 50% cortical/50% cancellous FDBA; Assigned to Arm(s): Combination 50% cortical/50% cancellous FDBA | Intervention Type: DEVICE; Name: 100% cortical FDBA; Assigned to Arm(s): 100% cortical FDBA | Intervention Type: DEVICE; Name: 100% cancellous FDBA; Assigned to Arm(s): 100% cancellous FDBA
D: Arm Label: Test: Porcine Xenograft (Zcore); Type: EXPERIMENTAL; Interventions: Device: Porcine Xenograft (Zcore) | Arm Label: Active Control: Bovine Xenograft (Bio-Oss); Type: ACTIVE_COMPARATOR; Interventions: Device: Bovine Xenograft (Bio-Oss) | Intervention Type: DEVICE; Name: Porcine Xenograft (Zcore); Assigned to Arm(s): Test: Porcine Xenograft (Zcore) | Intervention Type: DEVICE; Name: Bovine Xenograft (Bio-Oss); Assigned to Arm(s): Active Control: Bovine Xenograft (Bio-Oss)

Answer: C