Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A PHASE 3, MULTINATIONAL, RANDOMIZED, OPEN-LABEL, PARALLEL-ARM STUDY OF AVELUMAB (MSB0010718C) IN COMBINATION WITH AXITINIB (INLYTA(REGISTERED)) VERSUS SUNITINIB (SUTENT(REGISTERED)) MONOTHERAPY IN THE FIRST-LINE TREATMENT OF PATIENTS WITH ADVANCED RENAL CELL CARCINOMA
Brief Summary: This is a phase 3 randomized trial evaluating the anti-tumor activity and safety of avelumab in combination with axitinib and of sunitinib monotherapy, administered as first-line treatment, in patients with advanced renal cell carcinoma


Options:
A: Arm Label: Pazopanib; Type: EXPERIMENTAL; Interventions: Drug: Pazopanib, Behavioral: Quality of Life Assessment | Arm Label: Temsirolimus; Type: EXPERIMENTAL; Interventions: Drug: Temsirolimus, Behavioral: Quality of Life Assessment, Drug: Benadryl | Intervention Type: DRUG; Name: Pazopanib; Assigned to Arm(s): Pazopanib | Intervention Type: DRUG; Name: Temsirolimus; Assigned to Arm(s): Temsirolimus | Intervention Type: BEHAVIORAL; Name: Quality of Life Assessment; Assigned to Arm(s): Pazopanib, Temsirolimus | Intervention Type: DRUG; Name: Benadryl; Assigned to Arm(s): Temsirolimus
B: Arm Label: Avelumab in combination with axitinib; Type: EXPERIMENTAL; Interventions: Drug: Avelumab (MSB0010718C), Drug: Axitinib (AG-013736) | Arm Label: Sunitinib; Type: ACTIVE_COMPARATOR; Interventions: Drug: Sunitinib | Intervention Type: DRUG; Name: Avelumab (MSB0010718C); Assigned to Arm(s): Avelumab in combination with axitinib | Intervention Type: DRUG; Name: Axitinib (AG-013736); Assigned to Arm(s): Avelumab in combination with axitinib | Intervention Type: DRUG; Name: Sunitinib; Assigned to Arm(s): Sunitinib
C: Arm Label: Arm I (sunitinib malate); Type: EXPERIMENTAL; Interventions: Procedure: Biospecimen Collection, Procedure: Bone Scan, Procedure: Computed Tomography, Drug: Sunitinib Malate | Arm Label: Arm II (cabozantinib s-malate); Type: EXPERIMENTAL; Interventions: Procedure: Biospecimen Collection, Procedure: Bone Scan, Drug: Cabozantinib S-malate, Procedure: Computed Tomography | Arm Label: Arm III (crizotinib closed to accrual 12/5/18); Type: EXPERIMENTAL; Interventions: Procedure: Biospecimen Collection, Procedure: Bone Scan, Procedure: Computed Tomography, Drug: Crizotinib | Arm Label: Arm IV (savolitinib closed to accrual 12/5/18); Type: EXPERIMENTAL; Interventions: Procedure: Biospecimen Collection, Procedure: Bone Scan, Procedure: Computed Tomography, Drug: Savolitinib | Intervention Type: PROCEDURE; Name: Biospecimen Collection; Assigned to Arm(s): Arm I (sunitinib malate), Arm II (cabozantinib s-malate), Arm III (crizotinib closed to accrual 12/5/18), Arm IV (savolitinib closed to accrual 12/5/18) | Intervention Type: PROCEDURE; Name: Bone Scan; Assigned to Arm(s): Arm I (sunitinib malate), Arm II (cabozantinib s-malate), Arm III (crizotinib closed to accrual 12/5/18), Arm IV (savolitinib closed to accrual 12/5/18) | Intervention Type: DRUG; Name: Cabozantinib S-malate; Assigned to Arm(s): Arm II (cabozantinib s-malate) | Intervention Type: PROCEDURE; Name: Computed Tomography; Assigned to Arm(s): Arm I (sunitinib malate), Arm II (cabozantinib s-malate), Arm III (crizotinib closed to accrual 12/5/18), Arm IV (savolitinib closed to accrual 12/5/18) | Intervention Type: DRUG; Name: Crizotinib; Assigned to Arm(s): Arm III (crizotinib closed to accrual 12/5/18) | Intervention Type: DRUG; Name: Savolitinib; Assigned to Arm(s): Arm IV (savolitinib closed to accrual 12/5/18) | Intervention Type: DRUG; Name: Sunitinib Malate; Assigned to Arm(s): Arm I (sunitinib malate)
D: Arm Label: A; Type: EXPERIMENTAL; Interventions: Drug: Temsirolimus, Drug: Bevacizumab | Arm Label: B; Type: ACTIVE_COMPARATOR; Interventions: Drug: Sunitinib | Arm Label: C; Type: ACTIVE_COMPARATOR; Interventions: Drug: Bevacizumab, Drug: Interferon alpha-2a | Intervention Type: DRUG; Name: Temsirolimus; Assigned to Arm(s): A | Intervention Type: DRUG; Name: Bevacizumab; Assigned to Arm(s): A, C | Intervention Type: DRUG; Name: Sunitinib; Assigned to Arm(s): B | Intervention Type: DRUG; Name: Interferon alpha-2a; Assigned to Arm(s): C

Answer: B