Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke
Brief Summary: In France, the annual incidence rate of acute ischaemic stroke is around 150 000 patients, 65 % of whom keep long-term disability. Several multicentric randomized controlled trials have shown the benefit of a mechanical thrombectomy in the acute phase of ischaemic stroke on functional disability, compared to a medical treatment alone (thrombolysis).

The timeliness of revascularisation is an essential factor of good prognosis. This intra-arterial treatment, associated with thrombolysis if applicable, is the reference treatment of large-vessel occlusion. The stillness of the patient is required to control the safety of the recanalization. Currently, either a general anesthesia or a sedation can be performed.

Several studies have shown a trend to superiority of the sedation but none was conducted with a high level of proof methodology.

The aim of our multicentric randomized controlled trial is to compare sedation and general anesthesia during intra-arterial thrombectomy for an acute ischaemic stroke in the anterior cerebral circulation. The main outcome will be the efficacy on the functional neurological prognosis at 3 months.


Options:
A: Intervention Type: DRUG; Name: rt-PA 0.9 mg/kg verum or placebo Intravenous; Assigned to Arm(s): N/A
B: Arm Label: general anesthesia; Type: EXPERIMENTAL; Interventions: Drug: Etomidate, Drug: Succinylcholine, Drug: Propofol, Drug: Remifentanil | Arm Label: sedation; Type: EXPERIMENTAL; Interventions: Drug: Remifentanil, Drug: Lidocaine | Intervention Type: DRUG; Name: Etomidate; Assigned to Arm(s): general anesthesia | Intervention Type: DRUG; Name: Succinylcholine; Assigned to Arm(s): general anesthesia | Intervention Type: DRUG; Name: Propofol; Assigned to Arm(s): general anesthesia | Intervention Type: DRUG; Name: Remifentanil; Assigned to Arm(s): general anesthesia, sedation | Intervention Type: DRUG; Name: Lidocaine; Assigned to Arm(s): sedation
C: Arm Label: Local anesthesia; Type: OTHER; Interventions: Other: local anesthesia, Other: Spontaneous breathing | Arm Label: General anesthesia; Type: OTHER; Interventions: Other: Intravenous anesthetics, Other: Controlled ventilation | Intervention Type: OTHER; Name: Intravenous anesthetics; Assigned to Arm(s): General anesthesia | Intervention Type: OTHER; Name: local anesthesia; Assigned to Arm(s): Local anesthesia | Intervention Type: OTHER; Name: Controlled ventilation; Assigned to Arm(s): General anesthesia | Intervention Type: OTHER; Name: Spontaneous breathing; Assigned to Arm(s): Local anesthesia
D: Arm Label: Sedation; Type: ACTIVE_COMPARATOR; Interventions: Drug: Sedation, Procedure: Intra-arterial Thrombectomy | Arm Label: General Anesthesia; Type: ACTIVE_COMPARATOR; Interventions: Drug: General Anesthesia (GA), Procedure: Intra-arterial Thrombectomy | Intervention Type: DRUG; Name: Sedation; Assigned to Arm(s): Sedation | Intervention Type: DRUG; Name: General Anesthesia (GA); Assigned to Arm(s): General Anesthesia | Intervention Type: PROCEDURE; Name: Intra-arterial Thrombectomy; Assigned to Arm(s): General Anesthesia, Sedation

Answer: B