Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Vascular Effects of Regular Cigarettes Versus electronIc Cigarette Use
Brief Summary: The purpose of this study is to assess the effects of electronic cigarettes-nicotine and electronic cigarette-nicotine free on endothelial function as compared to traditional cigarettes. Due to ethical reasons, we cannot fully randomise all particpants to the three arms.

Participants who wish to quit smoking will be randomized to

1. Switch to electronic cigarettes containing nicotine plus flavor
2. Switch to electronic cigarettes containing flavor alone Those who do not wish to quit smoking will continue on the Tobacco Cigarette arm Treatment period will be 28 days


Options:
A: Arm Label: 0.8 mg nicotine with 9 mg tar; Type: EXPERIMENTAL; Interventions: Other: very low nicotine content cigarettes | Arm Label: 0.26 mg nicotine with 9 mg tar; Type: EXPERIMENTAL; Interventions: Other: very low nicotine content cigarettes | Arm Label: 0.12 mg nicotine with 9 mg tar; Type: EXPERIMENTAL; Interventions: Other: very low nicotine content cigarettes | Arm Label: 0.07 mg nicotine with 9 mg tar; Type: EXPERIMENTAL; Interventions: Other: very low nicotine content cigarettes | Arm Label: 0.03 mg nicotine with 9 mg tar; Type: EXPERIMENTAL; Interventions: Other: very low nicotine content cigarettes | Arm Label: 0.04 mg nicotine with 13 mg tar; Type: EXPERIMENTAL; Interventions: Other: very low nicotine content cigarettes | Arm Label: Usual brand; Type: OTHER; Interventions: Other: very low nicotine content cigarettes | Intervention Type: OTHER; Name: very low nicotine content cigarettes; Assigned to Arm(s): 0.03 mg nicotine with 9 mg tar, 0.04 mg nicotine with 13 mg tar, 0.07 mg nicotine with 9 mg tar, 0.12 mg nicotine with 9 mg tar, 0.26 mg nicotine with 9 mg tar, 0.8 mg nicotine with 9 mg tar, Usual brand
B: Arm Label: Traditional cigarette; Type: EXPERIMENTAL; Interventions: Behavioral: Smoke | Arm Label: Electronic cigarette; Type: EXPERIMENTAL; Interventions: Behavioral: Smoke | Arm Label: Heat-not-burn tobacco products (IQOS); Type: EXPERIMENTAL; Interventions: Behavioral: Smoke | Intervention Type: BEHAVIORAL; Name: Smoke; Assigned to Arm(s): Electronic cigarette, Heat-not-burn tobacco products (IQOS), Traditional cigarette
C: Arm Label: cigarette substitute; Type: EXPERIMENTAL; Interventions: Other: cigarette substitute | Arm Label: e-cigarette (with 0 mg/ml nicotine); Type: EXPERIMENTAL; Interventions: Other: e-cigarette | Arm Label: e-cigarette (with 8 mg/ml nicotine); Type: EXPERIMENTAL; Interventions: Other: e-cigarette | Arm Label: e-cigarette (with 36 mg/ml nicotine); Type: EXPERIMENTAL; Interventions: Other: e-cigarette | Intervention Type: OTHER; Name: e-cigarette; Assigned to Arm(s): e-cigarette (with 0 mg/ml nicotine), e-cigarette (with 36 mg/ml nicotine), e-cigarette (with 8 mg/ml nicotine) | Intervention Type: OTHER; Name: cigarette substitute; Assigned to Arm(s): cigarette substitute
D: Arm Label: tobacco cigarette; Type: ACTIVE_COMPARATOR; Interventions: Other: Tobacco cigarette | Arm Label: e.cigarettes + 16mg nicotine & flavor; Type: ACTIVE_COMPARATOR; Interventions: Device: electronic cigarette + 16mg nicotine & flavor | Arm Label: e.cigarettes + 0mg nicotine & flavour; Type: ACTIVE_COMPARATOR; Interventions: Other: electronic cigarette + 0mg nicotine & flavor | Intervention Type: DEVICE; Name: electronic cigarette + 16mg nicotine & flavor; Assigned to Arm(s): e.cigarettes + 16mg nicotine & flavor | Intervention Type: OTHER; Name: electronic cigarette + 0mg nicotine & flavor; Assigned to Arm(s): e.cigarettes + 0mg nicotine & flavour | Intervention Type: OTHER; Name: Tobacco cigarette; Assigned to Arm(s): tobacco cigarette

Answer: D