Please select the eligibility criteria that correspond to the clinical trial below.
Title: Improvement in Pain and Function Following a Therapeutic Exercise Program and Dry Needling in Older Adults With Knee Osteoarthritis: A Randomized Double-blind Multicenter Controlled Clinical Trial
Brief Summary: This study evaluates the combination of a therapeutic exercise program and dry needling in the treatment of knee osteoarthritis in older adults. Half of participants will receive therapeutic exercise program and dry needling in combination, while the other half will receive the same therapeutic exercise program and sham dry needling.


Options:
A: Inclusion Criteria:- Provision of informed consent to participate.

* Women with over 18 years old,with chronic pain because of primary osteoarthritis of the knee.
* Pain stable for at least three months. Score greater than or equal to 3 cm (0 cm = "no pain" and "worst possible pain" = 10cm) on Visual Analog Scale (VAS) for pain perception at baseline.
* No contraindications to electroacupuncture, transcranial direct current stimulation or transcranial magnetic stimulation.

Exclusion Criteria:-Clinically significant or unstable disorder, medical or psychiatric.

* Presence of neurological or rheumatic comorbidity.
* Pregnancy.
* Already having been treated with acupuncture.
* Having performed with corticosteroid infiltration in the last six weeks or are using this.
* Having performed with hyaluronic acid infiltration in the last year.
* Previous surgery on the limb to be treated or have surgical program for the next 6 months.
B: Inclusion Criteria:

* patients referred from general practitioner, chiropractor or orthopaedic surgeon
* unilateral hip pain of minimum 3 months' duration
* radiology criteria for hip OA: joint space width (JSW) \< 2.0 mm or a side difference in JSW of \> 10%
* adequate mastering of the Danish language to complete instructions and questionnaires

Exclusion Criteria:

* inflammatory joint disease
* previous hip or knee alloplastic
* secondary arthritis due to hip fracture or infection
* bilateral hip pain
* hip dysplasia with a CE angle \> 25 degrees and an AA angle \> 10 degrees
* low back pain which dominates over the hip pain
* malignant disease
* patients with paresis or paralysis after neuromuscular, cerebrovascular or polyneuropathic disease
* hip pain resulting from labral tear, bursitis and/or snapping hip syndrome
* polyarthritis
* received manual treatment for the hip within the last year
C: Inclusion Criteria:

* Participants aged 62 years and older.
* Unilateral or bilateral disfunction and/or knee pain.
* Primary knee ostearthritis fulfilling the American College of Rheumatology criteria for clinical and radiographic diagnostic.
* At least 1 pain point elicited by palpation ipsilateral to the painful knee situated in a taut band of a skeletal muscle of the lower limbs, which usually have referred pain.

Exclusion Criteria:

* Prior diagnoses or prescriptions in the medical record for myopathy or lumbo-sacral neuropathy.
* Previous knee or hip joint replacement surgery of the affected joint.
* Any other surgical procedure of the lower limbs in the previous 6 months.
* Rheumatoid arthritis.
* Initiation of opioid analgesia or cortico-steroid or analgesic injection intervention for hip or knee pain within the previous 30 days.
* Alcohol or drugs consumption.
* Uncontrolled hypertension or moderate to high risk for cardiac complications during exercise.
* Conservative or invasive physical therapy (previous 6 months or during follow-up).
* Taking antiaggregant or anticoagulant medications.
* Physical impairments unrelated to the hip or knee preventing safe participation in exercise, walking or stationary cycling, such as: vision problems that affect mobility, body weight greater than 155 kg, neurogenic disorder, primary or significantly limiting back pain, advanced osteoporosis, or inability to walk 10 metres without an assistive device.
* Inability to comprehend and complete study assessments or comply with study instructions.
* Stated inability to attend or complete the proposed course of intervention and follow-up schedule.
* Fibromyalgia syndrome or other altered affective/cognitive modulation processes of pain perception. .
D: Inclusion Criteria:

* Grade II to III radiographic tibiofemoral OA of one or both knees
* Body mass index (BMI) of 27 to 37
* Sedentary lifestyle, defined as not participating in more than 30 minutes of formal exercise per week within the 6 months prior to study entry

Exclusion Criteria:

* Significant comorbidity that may pose a safety risk to the participant or otherwise interfere with the study. More information about this criterion can be found in the protocol.
* Previous acute knee injury
* Knee injection within 1 month of study entry
* Knee surgery within 6 months of study entry
* Knee OA other than tibiofemoral OA
* Unwilling or unable to change eating and physical activity habits due to environment
* Cannot speak or read English
* Excess alcohol use (21 or more drinks per week)
* Unable to finish the 18-month study or unlikely to comply with the study
* Unable to undergo MRI of the knee
* Significant cognitive impairment

Answer: C