Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomised, Double-blind, 8 Treatments, 4 Periods, Incomplete Crossover Study to Determine the Optimal Free Dose Combination of BI 1744 CL and Tiotropium Bromide (Both Delivered by the Respimat® Inhaler) After 4 Weeks Once Daily Treatment in Patients With COPD
Brief Summary: The primary objective of this study is to determine the optimum once daily dose of BI 1744 CL and tiotropium in free dose combination (delivered by the Respimat inhaler) after four week treatment in patients with COPD.


Options:
A: Arm Label: olodaterol (BI 1744) low and placebo; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) low, Drug: Placebo, Device: Respimat | Arm Label: olodaterol (BI 1744) low and low tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) low, Drug: low tiotropium bromide, Device: Respimat | Arm Label: olodaterol (BI 1744) low and medium tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) low, Drug: medium tiotropium bromide, Device: Respimat | Arm Label: olodaterol (BI 1744) low and high tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) low, Drug: high tiotropium bromide, Device: Respimat | Arm Label: olodaterol (BI 1744) high and placebo; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) high, Drug: Placebo, Device: Respimat | Arm Label: Olodaterol (BI 1744) high and low tio; Type: EXPERIMENTAL; Interventions: Drug: low tiotropium bromide, Drug: olodaterol (BI 1744) high, Device: Respimat | Arm Label: Olodaterol (BI 1744) high and medium tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) high, Drug: medium tiotropium bromide, Device: Respimat | Arm Label: Olodaterol (BI 1744) high and high tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) high, Drug: high tiotropium bromide, Device: Respimat | Intervention Type: DRUG; Name: olodaterol (BI 1744) low; Assigned to Arm(s): olodaterol (BI 1744) low and high tio, olodaterol (BI 1744) low and low tio, olodaterol (BI 1744) low and medium tio, olodaterol (BI 1744) low and placebo | Intervention Type: DRUG; Name: low tiotropium bromide; Assigned to Arm(s): Olodaterol (BI 1744) high and low tio, olodaterol (BI 1744) low and low tio | Intervention Type: DRUG; Name: olodaterol (BI 1744) high; Assigned to Arm(s): Olodaterol (BI 1744) high and high tio, Olodaterol (BI 1744) high and low tio, Olodaterol (BI 1744) high and medium tio, olodaterol (BI 1744) high and placebo | Intervention Type: DRUG; Name: medium tiotropium bromide; Assigned to Arm(s): Olodaterol (BI 1744) high and medium tio, olodaterol (BI 1744) low and medium tio | Intervention Type: DRUG; Name: high tiotropium bromide; Assigned to Arm(s): Olodaterol (BI 1744) high and high tio, olodaterol (BI 1744) low and high tio | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): olodaterol (BI 1744) high and placebo, olodaterol (BI 1744) low and placebo | Intervention Type: DEVICE; Name: Respimat; Assigned to Arm(s): Olodaterol (BI 1744) high and high tio, Olodaterol (BI 1744) high and low tio, Olodaterol (BI 1744) high and medium tio, olodaterol (BI 1744) high and placebo, olodaterol (BI 1744) low and high tio, olodaterol (BI 1744) low and low tio, olodaterol (BI 1744) low and medium tio, olodaterol (BI 1744) low and placebo
B: Arm Label: tiotropium+olodaterol low dose; Type: EXPERIMENTAL; Interventions: Device: Respimat inhaler, Drug: tiotropium+olodaterol (low dose) | Arm Label: tiotropium+olodaterol high dose; Type: EXPERIMENTAL; Interventions: Drug: tiotropium + olodaterol (high dose), Device: Respimat inhaler | Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Device: Respimat inhaler, Drug: placebo to tiotropium+olodaterol | Intervention Type: DEVICE; Name: Respimat inhaler; Assigned to Arm(s): tiotropium+olodaterol low dose | Intervention Type: DRUG; Name: tiotropium+olodaterol (low dose); Assigned to Arm(s): tiotropium+olodaterol low dose | Intervention Type: DRUG; Name: tiotropium + olodaterol (high dose); Assigned to Arm(s): tiotropium+olodaterol high dose | Intervention Type: DEVICE; Name: Respimat inhaler; Assigned to Arm(s): tiotropium+olodaterol high dose | Intervention Type: DEVICE; Name: Respimat inhaler; Assigned to Arm(s): placebo | Intervention Type: DRUG; Name: placebo to tiotropium+olodaterol; Assigned to Arm(s): placebo
C: Arm Label: Olodaterol 5 mcg QD; Type: ACTIVE_COMPARATOR; Interventions: Drug: Olodaterol, Device: Respimat | Arm Label: Placebo QD; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Device: Respimat | Arm Label: Tiotropium 5 mcg QD; Type: ACTIVE_COMPARATOR; Interventions: Drug: Tiotropium, Device: Respimat | Arm Label: Tiotropium + olodaterol low dose QD; Type: EXPERIMENTAL; Interventions: Drug: Tiotropium + Olodaterol, Device: Respimat | Arm Label: Tiotropium + olodaterol high dose; Type: EXPERIMENTAL; Interventions: Drug: tiotropium + Olodaterol, Device: Respimat | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo QD | Intervention Type: DRUG; Name: Tiotropium + Olodaterol; Assigned to Arm(s): Tiotropium + olodaterol low dose QD | Intervention Type: DRUG; Name: tiotropium + Olodaterol; Assigned to Arm(s): Tiotropium + olodaterol high dose | Intervention Type: DRUG; Name: Tiotropium; Assigned to Arm(s): Tiotropium 5 mcg QD | Intervention Type: DRUG; Name: Olodaterol; Assigned to Arm(s): Olodaterol 5 mcg QD | Intervention Type: DEVICE; Name: Respimat; Assigned to Arm(s): Olodaterol 5 mcg QD, Placebo QD, Tiotropium + olodaterol high dose, Tiotropium + olodaterol low dose QD, Tiotropium 5 mcg QD
D: Arm Label: GFF MDI (PT003); Type: EXPERIMENTAL; Interventions: Drug: GFF MDI (PT003) | Arm Label: Placebo MDI; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo MDI | Intervention Type: DRUG; Name: GFF MDI (PT003); Assigned to Arm(s): GFF MDI (PT003) | Intervention Type: DRUG; Name: Placebo MDI; Assigned to Arm(s): Placebo MDI

Answer: A