Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Clinical Trial Comparing Preoperative Radiation Therapy And Capecitabine With or Without Oxaliplatin With Preoperative Radiation Therapy And Continuous Intravenous Infusion Of 5-Fluorouracil With or Without Oxaliplatin In The Treatment Of Patients With Operable Carcinoma Of The Rectum
Brief Summary: RATIONALE: Drugs used in chemotherapy, such as capecitabine, fluorouracil, and oxaliplatin work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.

PURPOSE: This randomized phase III trial is studying radiation therapy and either capecitabine or fluorouracil with or without oxaliplatin and comparing them to see how well they work when given before surgery in treating patients with resectable rectal cancer. It is not yet known whether radiation therapy and either capecitabine or fluorouracil is more effective with or without oxaliplatin in treating rectal cancer.


Options:
A: Arm Label: FOLFOX4; Type: ACTIVE_COMPARATOR; Interventions: Drug: 5-Fluorouracil (5-FU), Drug: Leucovorin calcium, Drug: Oxaliplatin | Arm Label: FOLFOX4 + Bv; Type: EXPERIMENTAL; Interventions: Biological: Bevacizumab, Drug: 5-Fluorouracil (5-FU), Drug: Leucovorin calcium, Drug: Oxaliplatin | Arm Label: XELOX+Bv; Type: EXPERIMENTAL; Interventions: Biological: Bevacizumab, Drug: Capecitabine, Drug: Oxaliplatin | Intervention Type: BIOLOGICAL; Name: Bevacizumab; Assigned to Arm(s): FOLFOX4 + Bv, XELOX+Bv | Intervention Type: DRUG; Name: Capecitabine; Assigned to Arm(s): XELOX+Bv | Intervention Type: DRUG; Name: 5-Fluorouracil (5-FU); Assigned to Arm(s): FOLFOX4, FOLFOX4 + Bv | Intervention Type: DRUG; Name: Leucovorin calcium; Assigned to Arm(s): FOLFOX4, FOLFOX4 + Bv | Intervention Type: DRUG; Name: Oxaliplatin; Assigned to Arm(s): FOLFOX4, FOLFOX4 + Bv, XELOX+Bv
B: Intervention Type: DRUG; Name: fluorouracil; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: leucovorin calcium; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): N/A | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): N/A
C: Arm Label: Arm 1: 5-FU + RT; Type: ACTIVE_COMPARATOR; Interventions: Drug: fluorouracil, Radiation: radiation therapy | Arm Label: Arm 2: 5-FU + RT + Oxaliplatin; Type: EXPERIMENTAL; Interventions: Drug: fluorouracil, Drug: oxaliplatin, Radiation: radiation therapy | Arm Label: Arm 3: Capecitabine + RT; Type: EXPERIMENTAL; Interventions: Drug: capecitabine, Radiation: radiation therapy | Arm Label: Arm 4: Capecitabine + RT + Oxaliplatin; Type: EXPERIMENTAL; Interventions: Drug: capecitabine, Drug: oxaliplatin, Radiation: radiation therapy | Intervention Type: DRUG; Name: capecitabine; Assigned to Arm(s): Arm 3: Capecitabine + RT, Arm 4: Capecitabine + RT + Oxaliplatin | Intervention Type: DRUG; Name: fluorouracil; Assigned to Arm(s): Arm 1: 5-FU + RT, Arm 2: 5-FU + RT + Oxaliplatin | Intervention Type: DRUG; Name: oxaliplatin; Assigned to Arm(s): Arm 2: 5-FU + RT + Oxaliplatin, Arm 4: Capecitabine + RT + Oxaliplatin | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): Arm 1: 5-FU + RT, Arm 2: 5-FU + RT + Oxaliplatin, Arm 3: Capecitabine + RT, Arm 4: Capecitabine + RT + Oxaliplatin
D: Arm Label: Placebo/FOLFIRI; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Drug: FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin) | Arm Label: Aflibercept/FOLFIRI; Type: EXPERIMENTAL; Interventions: Drug: Aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®), Drug: FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin) | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo/FOLFIRI | Intervention Type: DRUG; Name: Aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®); Assigned to Arm(s): Aflibercept/FOLFIRI | Intervention Type: DRUG; Name: FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin); Assigned to Arm(s): Placebo/FOLFIRI | Intervention Type: DRUG; Name: FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin); Assigned to Arm(s): Aflibercept/FOLFIRI

Answer: C