Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study of the Effects of Chitin-Glucan on Oxidized Low-Density Lipoprotein (LDL)
Brief Summary: Cardiovascular diseases (CVDs), especially atherosclerotic coronary heart disease and stroke, are the leading causes of death globally. Important risk factors for CVDs include elevated serum levels of total cholesterol, low-density lipoprotein(LDL)-cholesterol, triglycerides, and low high-density lipoprotein (HDL)-cholesterol. Elevated "oxidized" LDL, a pro-inflammatory villain, has also emerged as an important risk factor for the development of CVDs. There is a growing need to identify safe and effective nutritional interventions that offer a clinical benefit aimed at reducing one more of the risk factors for CVDs. Data from many studies in humans have shown various health benefits provided by dietary fiber intake, including an inverse association with the risk of developing cardiovascular disease. The primary purpose of this study is to determine whether daily consumption for 6 weeks of chitin-glucan, a fiber purified from a microorganism, is effective at reducing the amount of oxidized LDL in humans with borderline-to-high LDL-cholesterol. The effects of chitin-glucan on other cardiovascular risk factors will also be evaluated.


Options:
A: Arm Label: biscuits without soy fiber; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: biscuits supplemented with soy fiber | Arm Label: biscuits supplemented with soy fiber; Type: EXPERIMENTAL; Interventions: Dietary Supplement: biscuits supplemented with soy fiber | Intervention Type: DIETARY_SUPPLEMENT; Name: biscuits supplemented with soy fiber; Assigned to Arm(s): biscuits supplemented with soy fiber, biscuits without soy fiber
B: Arm Label: Pulse Fibre; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Pulse fibre | Arm Label: Control; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Control | Intervention Type: DIETARY_SUPPLEMENT; Name: Pulse fibre; Assigned to Arm(s): Pulse Fibre | Intervention Type: DIETARY_SUPPLEMENT; Name: Control; Assigned to Arm(s): Control
C: Arm Label: High Dose Chitin-Glucan; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Chitin-Glucan | Arm Label: Low Dose Chitin-Glucan; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Low Dose Chitin-Glucan | Arm Label: Low Dose Chitin-Glucan + Olive Extract; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Low Dose Chitin-Glucan + Olive Extract | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: Chitin-Glucan; Assigned to Arm(s): High Dose Chitin-Glucan | Intervention Type: DIETARY_SUPPLEMENT; Name: Low Dose Chitin-Glucan; Assigned to Arm(s): Low Dose Chitin-Glucan | Intervention Type: DIETARY_SUPPLEMENT; Name: Low Dose Chitin-Glucan + Olive Extract; Assigned to Arm(s): Low Dose Chitin-Glucan + Olive Extract | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo; Assigned to Arm(s): Placebo
D: Arm Label: Intensive Portfolio; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Dietary Portfolio - Intensive | Arm Label: Routine Portfolio; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Dietary Portfolio - Routine | Arm Label: Control; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Control (low saturated fat therapeutic diet) | Intervention Type: DIETARY_SUPPLEMENT; Name: Dietary Portfolio - Intensive; Assigned to Arm(s): Intensive Portfolio | Intervention Type: DIETARY_SUPPLEMENT; Name: Dietary Portfolio - Routine; Assigned to Arm(s): Routine Portfolio | Intervention Type: DIETARY_SUPPLEMENT; Name: Control (low saturated fat therapeutic diet); Assigned to Arm(s): Control

Answer: C