Please select the eligibility criteria that correspond to the clinical trial below.
Title: RCT of Stepping Stones Behavioural Intervention for HIV
Brief Summary: This study will evaluate the effectiveness of Stepping Stones, an HIV-prevention education program, versus a brief HIV-focused intervention, in improving sexual health and preventing HIV infection in young residents of rural South African communities.


Options:
A: Inclusion Criteria:

* Resident of the village in which individual is studying (i.e., not a migrant scholar)
* Mature enough to understand the study and the consent process

Exclusion Criteria:

* N/A
B: Inclusion Criteria:

* Each partner agrees that the relationship has lasted at least 6 months before study entry
* Each partner intends to remain together for at least 12 months after study entry (e.g., state independently that he/she is confident or very confident that they will remain together)
* At least one partner of the couple reports having unprotected intercourse at least once in the 90 days before study entry
* Neither partner has plans to relocate beyond a reasonable distance from the study site
* At least one partner is African American
* At least one partner agrees that he/she is not planning pregnancy within the next 18 months after study entry
* Each partner is aware of his/her partner's HIV serostatus
* Only one partner is HIV seropositive and has known his or her status for at least 3 months before study entry

Exclusion Criteria:

* One or both partners do not have an address where they can receive mail
* One or both partners have significant psychiatric, physical, or neurological impairment that would limit their effective participation as confirmed on a Mini Mental State Examination and/or Quick Test
* History of severe physical or sexual abuse in the 1 year before study entry in the current relationship (e.g., significant enough to require medical, psychological, and/or legal intervention)
* One or both partners are unwilling or unable to commit to participate in the study through to completion
* Both partners have previously participated in an HIV sexual risk-reduction intervention for couples in the 12 months before study entry
* One or both partners are not fluent in English as determined by the informed consent process
C: Inclusion Criteria for HIV Infected Partner:

* Positive HIV test within 60 days of study entry
* CD4 count between 350 and 550 cells/mm3 within 30 days of study entry
* If pregnant or breastfeeding, willing to be randomized to either arm of the study

Inclusion Criteria for HIV Uninfected Partner:

* Negative HIV test within 14 days of study entry

Inclusion Criteria for Both Partners:

* Plans to maintain sexual relationship with partner
* Reports having sex (vaginal or anal) with partner at least three times in the last 3 months
* Willing to disclose HIV test results to partner
* Plans to stay in the area and does not have a job or other obligations that may require long absences during the duration of the study

Exclusion Criteria for HIV Infected Partner:

* Current or previous use of any ART. Participants who previously took a short-term course of ART for prevention of mother-to-child transmission of HIV are not excluded.
* Documented or suspected acute hepatitis within 30 days of study entry, if the infected partner's starting regimen in the study contains nevirapine or atazanavir
* Current or previous AIDS-defining illness or opportunistic infection
* Documented or suspected acute hepatitis within 30 days prior to study entry
* Acute therapy of serious medical illnesses within 14 days prior to study entry
* Radiation therapy or systemic chemotherapy within 45 days prior to study entry
* Immunomodulatory or investigational therapy within 30 days prior to study entry
* Active drug or alcohol dependence that, in the opinion of the investigator, would interfere with the study
* Vomiting or inability to swallow medications
* Require certain medications
* Allergy or sensitivity to any of the study drugs

Exclusion Criteria for Both Partners:

* History of injection drug use within 5 years of study entry
* Previous and/or current participation in an HIV vaccine study
* Currently detained in jail or for treatment of a psychiatric or physical illness
* Any condition that, in the opinion of the study staff, would make participation in the study unsafe, complicate interpretation of study outcome data, or otherwise interfere with achieving the study objectives
* Certain abnormal laboratory values
D: Inclusion Criteria:

* Either lives, works, or socializes in the selected venues
* Plans to remain in the venue for at least 1 year after study entry

Exclusion Criteria:

* Permanent disability that hinders participation (e.g. deaf, mental retardation)
* Reports no sex in the 6 months before study entry (China, Peru)
* No STDs present at study entry (China)
* Enrolled in final year of school at time of recruitment (Russia)
* Has lived in venue for less than 2 years (Zimbabwe)
* Lives in venue for less than 9 months out of a year (Zimbabwe)

Answer: A