Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: CSP #594 - Comparative Effectiveness in Gout: Allopurinol vs. Febuxostat
Brief Summary: This trial will compare two effective therapies, allopurinol and febuxostat, to lower serum uric acid and therefore prevent further gout attacks. These therapies have never been compared at appropriate doses. Further, they will be studied in patients with kidney disease for the first time.


Options:
A: Arm Label: lesinurad 400 mg + febuxostat 80 mg; Type: EXPERIMENTAL; Interventions: Drug: Lesinurad, Drug: Febuxostat | Arm Label: lesinurad 200 mg + febuxostat 80 mg; Type: EXPERIMENTAL; Interventions: Drug: Lesinurad, Drug: Febuxostat | Arm Label: placebo + febuxostat 80 mg; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Drug: Febuxostat | Intervention Type: DRUG; Name: Lesinurad; Assigned to Arm(s): lesinurad 400 mg + febuxostat 80 mg | Intervention Type: DRUG; Name: Lesinurad; Assigned to Arm(s): lesinurad 200 mg + febuxostat 80 mg | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): placebo + febuxostat 80 mg | Intervention Type: DRUG; Name: Febuxostat; Assigned to Arm(s): lesinurad 200 mg + febuxostat 80 mg, lesinurad 400 mg + febuxostat 80 mg, placebo + febuxostat 80 mg
B: Arm Label: Allopurinol / Sham Comparator (Febuxostat); Type: ACTIVE_COMPARATOR; Interventions: Drug: allopurinol capsule, 100-800 mg by mouth once daily, Drug: Placebo, vehicle control (febuxostat-shaped) | Arm Label: Febuxostat / Sham Comparator (Allopurinol); Type: ACTIVE_COMPARATOR; Interventions: Drug: febuxostat tablet 40-120 mg by mouth once daily, Drug: Placebo, vehicle control (allopurinol-shaped) | Intervention Type: DRUG; Name: allopurinol capsule, 100-800 mg by mouth once daily; Assigned to Arm(s): Allopurinol / Sham Comparator (Febuxostat) | Intervention Type: DRUG; Name: febuxostat tablet 40-120 mg by mouth once daily; Assigned to Arm(s): Febuxostat / Sham Comparator (Allopurinol) | Intervention Type: DRUG; Name: Placebo, vehicle control (febuxostat-shaped); Assigned to Arm(s): Allopurinol / Sham Comparator (Febuxostat) | Intervention Type: DRUG; Name: Placebo, vehicle control (allopurinol-shaped); Assigned to Arm(s): Febuxostat / Sham Comparator (Allopurinol)
C: Arm Label: lesinurad 200 mg + allopurinol; Type: EXPERIMENTAL; Interventions: Drug: Lesinurad, Drug: Allopurinol | Arm Label: lesinurad 400 mg + allopurinol; Type: EXPERIMENTAL; Interventions: Drug: Lesinurad, Drug: Allopurinol | Arm Label: Placebo + allopurinol; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Drug: Allopurinol | Intervention Type: DRUG; Name: Lesinurad; Assigned to Arm(s): lesinurad 200 mg + allopurinol | Intervention Type: DRUG; Name: Lesinurad; Assigned to Arm(s): lesinurad 400 mg + allopurinol | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo + allopurinol | Intervention Type: DRUG; Name: Allopurinol; Assigned to Arm(s): lesinurad 200 mg + allopurinol | Intervention Type: DRUG; Name: Allopurinol; Assigned to Arm(s): lesinurad 400 mg + allopurinol | Intervention Type: DRUG; Name: Allopurinol; Assigned to Arm(s): Placebo + allopurinol
D: Arm Label: q2 wks; Type: EXPERIMENTAL; Interventions: Biological: pegloticase | Arm Label: q4 wks; Type: EXPERIMENTAL; Interventions: Biological: pegloticase | Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Intervention Type: OTHER; Name: placebo; Assigned to Arm(s): placebo | Intervention Type: BIOLOGICAL; Name: pegloticase; Assigned to Arm(s): q2 wks, q4 wks

Answer: B