Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized Phase III Trial of CC-5013 (Lenalidomide, NSC-703813) and Low Dose Dexamethasone (LLD) Versus Bortezomib (PS-341, NSC-681239), Lenalidomide And Low Dose Dexamethasone (BLLD) for Induction, in Patients With Previously Untreated Multiple Myeloma Without an Intent for Immediate Autologous Stem Cell Transplant
Brief Summary: This randomized phase III trial studies lenalidomide, dexamethasone, and bortezomib to see how well it works compared to dexamethasone and lenalidomide alone in treating patients with previously untreated multiple myeloma. Biological therapies, such as lenalidomide, may stimulate the immune system in different ways and stop cancer cells from growing. Drugs used in chemotherapy, such as dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth or by blocking blood flow to the cancer. It is not yet known whether lenalidomide and dexamethasone is more effective with or without bortezomib in treating multiple myeloma.


Options:
A: Arm Label: Arm I (dexamethasone and lenalidomide); Type: ACTIVE_COMPARATOR; Interventions: Drug: Dexamethasone, Other: Laboratory Biomarker Analysis, Drug: Lenalidomide | Arm Label: Arm II (dexamethasone, lenalidomide, bortezomib); Type: EXPERIMENTAL; Interventions: Drug: Bortezomib, Drug: Dexamethasone, Other: Laboratory Biomarker Analysis, Drug: Lenalidomide | Intervention Type: DRUG; Name: Bortezomib; Assigned to Arm(s): Arm II (dexamethasone, lenalidomide, bortezomib) | Intervention Type: DRUG; Name: Dexamethasone; Assigned to Arm(s): Arm I (dexamethasone and lenalidomide), Arm II (dexamethasone, lenalidomide, bortezomib) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Arm I (dexamethasone and lenalidomide), Arm II (dexamethasone, lenalidomide, bortezomib) | Intervention Type: DRUG; Name: Lenalidomide; Assigned to Arm(s): Arm I (dexamethasone and lenalidomide), Arm II (dexamethasone, lenalidomide, bortezomib)
B: Arm Label: MPR+R; Type: EXPERIMENTAL; Interventions: Drug: Lenalidomide: Double-blind Induction, Drug: Melphalan, Drug: Prednisone, Drug: Aspirin, Drug: Lenalidomide: Double-blind Maintenance, Drug: Lenalidomide: Open-label | Arm Label: MPR+p; Type: EXPERIMENTAL; Interventions: Drug: Lenalidomide: Double-blind Induction, Drug: Melphalan, Drug: Prednisone, Drug: Aspirin, Drug: Placebo, Drug: Lenalidomide: Open-label | Arm Label: MPp+p; Type: OTHER; Interventions: Drug: Melphalan, Drug: Prednisone, Drug: Aspirin, Drug: Placebo, Drug: Lenalidomide: Open-label | Intervention Type: DRUG; Name: Lenalidomide: Double-blind Induction; Assigned to Arm(s): MPR+R, MPR+p | Intervention Type: DRUG; Name: Melphalan; Assigned to Arm(s): MPR+R, MPR+p, MPp+p | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): MPR+R, MPR+p, MPp+p | Intervention Type: DRUG; Name: Aspirin; Assigned to Arm(s): MPR+R, MPR+p, MPp+p | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): MPR+p, MPp+p | Intervention Type: DRUG; Name: Lenalidomide: Double-blind Maintenance; Assigned to Arm(s): MPR+R | Intervention Type: DRUG; Name: Lenalidomide: Open-label; Assigned to Arm(s): MPR+R, MPR+p, MPp+p
C: Arm Label: Arm I (thalidomide); Type: ACTIVE_COMPARATOR; Interventions: Other: Laboratory Biomarker Analysis, Drug: Melphalan, Drug: Prednisone, Other: Quality-of-Life Assessment, Drug: Thalidomide | Arm Label: Arm II (lenalidomide); Type: EXPERIMENTAL; Interventions: Other: Laboratory Biomarker Analysis, Drug: Lenalidomide, Drug: Melphalan, Drug: Prednisone | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Arm I (thalidomide), Arm II (lenalidomide) | Intervention Type: DRUG; Name: Lenalidomide; Assigned to Arm(s): Arm II (lenalidomide) | Intervention Type: DRUG; Name: Melphalan; Assigned to Arm(s): Arm I (thalidomide), Arm II (lenalidomide) | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): Arm I (thalidomide), Arm II (lenalidomide) | Intervention Type: OTHER; Name: Quality-of-Life Assessment; Assigned to Arm(s): Arm I (thalidomide) | Intervention Type: DRUG; Name: Thalidomide; Assigned to Arm(s): Arm I (thalidomide)
D: Arm Label: Arm I; Type: EXPERIMENTAL; Interventions: Drug: dexamethasone, Drug: lenalidomide | Arm Label: Arm II; Type: ACTIVE_COMPARATOR; Interventions: Drug: dexamethasone, Other: placebo | Intervention Type: DRUG; Name: dexamethasone; Assigned to Arm(s): Arm I, Arm II | Intervention Type: DRUG; Name: lenalidomide; Assigned to Arm(s): Arm I | Intervention Type: OTHER; Name: placebo; Assigned to Arm(s): Arm II

Answer: A