Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Randomised Controlled Trial of Rehabilitation Following Critical Illness: A Short Term Feasibility and Follow-Up Pilot Study
Brief Summary: The principal research question to be answered by this study is whether an exercise based rehabilitative intervention following critical illness can generate improvements in exercise capacity and quality of life beyond current (usual) care. The investigators will also aim to demonstrate that such an intervention is both practical and cost-effective.


Options:
A: Inclusion Criteria:

* Age \>18 years AND admitted to critical care unit
* Ventilated \>48-hours (via endotracheal tube) OR received continuous non- invasive ventilation (NIV)/non-invasive continuous positive airways pressure (CPAP)
* Admitted to ICU \> 48-hours and evidence of SIRS
* Glasgow Coma Score (GCS) 15 (of 15) AND Abbreviated Mini-Mental Test Score (AMMTS) \>/= 8 (of 10) on enrolment into rehabilitation programme
* Mobilising on ward to a degree sufficient as to begin a majority of proposed exercises. Clinical stability for observed exercise as judged by trial team is a prerequisite.
* Participant willingness to complete a programme of exercise based therapy aimed at reducing weakness and shortness of breath: subjective weakness or dyspnoea relative to their pre-admission state is implicit

Exclusion Criteria:

* Patients referred for terminal care or prognosis likely to be less than 12-months
* Unstable coronary artery syndrome
* Limb amputation (given special requirement for orthotics/rehabilitation)
* Critical peripheral vascular disease awaiting re-vascularisation procedure (or claudication distance \<100 metres)
* Stroke with hemiparesis (likely need for specialised rehabilitation/stay on stroke unit)
* Severe, disabling locomotor problem or severe burns, which prevent effective participation in the exercises contained in the rehabilitation programme.
* Psychiatric disease necessitating anti-psychotic medication, deliberate drug overdose as the admitting ICU indication, ongoing treatment for drug or alcohol addiction, persons of no fixed abode post-discharge
* Patients undergoing renal haemodialysis (given the associated commitment to outpatient attendance)
* Extra contractual ICU referral (only if distance greater than suitable for twice weekly travel)

Additional exclusion criteria for muscle biopsy samples:

* Coagulopathy e.g. warfarin use
B: Inclusion Criteria:

* Diagnosed type 1 or 2 diabetes mellitus
* Age 50 years or older
* Absent 5.07 Semmes Weinstein monofilament sensation to \> 1 point on both feet
* Residence within 50 miles of Columbia, MO
* Functioning telephone service
* Not currently participating in 20 or more minutes of moderately intense activity more than twice a week

Exclusion Criteria:

* Hospitalization in the last year for any of the following reasons:
* Proliferative diabetic retinopathy
* Accelerated hypertension (systolic BP \>200 or diastolic BP \> 120)
* Myocardial infarction or unstable angina
* New hemodynamically significant arrhythmia
* Acute congestive heart failure
* Failure to attend 3 of the last 5 scheduled clinic visits
* Foot deformities requiring a custom shoe
* "Timed Up and Go" test 3 \> 15 seconds Subjects unable to ambulate without assistance
* Severe cardiac autonomic neuropathy
* Lower extremity amputation \> one digit
* Heart, kidney or other transplant
* Currently unhealed foot ulcer (or healed for less than 1 month
C: Inclusion Criteria:

* (Suspected) diagnosis of neuralgic amyotrophy
* In subacute or chronic phase of neuralgic amyotrophy (\>2 months after attack onset)
* Right-handed
* Neuralgic amyotrophy predominantly present in right upper extremity
* Presence of scapular dyskinesia

Exclusion Criteria:

* Patients in the acute phase of NA (characterized by severe pain and inflammation of the brachial plexus)
* (Prior) NA attacks of the lumbosacral plexus or the left upper extremity
* Sever comorbidity
* Any (bio)mechanical constraints of the shoulder girdle
* Any other central nervous system, neurological, or neuromuscular disorder
D: Inclusion Criteria:

* Be experiencing a permanent disability of at least 6 months that limits mobility sufficiently to require use of a wheelchair as the primary method of mobility outside the home
* Have not been moderately to vigorously physically active for the past 6 months
* Be willing to attend the educational workshop
* Receive physician approval for participation

Exclusion criteria include:

* Presence of medical conditions such as uncontrolled cardiovascular problems that the patient's physician identifies as being contraindicated for exercise
* Pregnancy or planning to become pregnant

Answer: A