Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Double-blind, Randomized, Placebo-controlled, Cross - Over Design, Single Center Study to Evaluate the Effects of Treatment With Pycnogenol® on Endothelial Function in Subjects With Stable Coronary Artery Disease (Pycno2007-003)
Brief Summary: Pycnogenol® is a proprietary bark extract of the French maritime pine tree (Pinus pinaster ssp. atlantica). Pycnogenol® has prevented pathologic symptoms such as chronic inflammation and increased platelet aggregation, a risk factor for cardiovascular diseases. The endothelium is increasingly recognized not only a target (with vascular remodelling occurring in response to an injury and resulting in atherosclerosis), but also a mediator in the pathogenesis of atherosclerosis. Indeed, endothelial cells play an important regulatory role in the cardiovascular system by the expression of numerous molecules and release of mediators such as nitric oxide (NO), superoxide and endothelin-1 (ET-1). Data from animal studies, as well as human studies indicate that Pycnogenol may improve endothelial function, which is a powerful surrogate for clinical prognosis.


Options:
A: Arm Label: Product one; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo | Arm Label: Product two; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Oligopin® | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo; Assigned to Arm(s): Product one | Intervention Type: DIETARY_SUPPLEMENT; Name: Oligopin®; Assigned to Arm(s): Product two
B: Arm Label: Pycnogenol; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Pycnogenol | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Arm Label: Methylphenidate; Type: ACTIVE_COMPARATOR; Interventions: Drug: Methylphenidate | Intervention Type: DIETARY_SUPPLEMENT; Name: Pycnogenol; Assigned to Arm(s): Pycnogenol | Intervention Type: DRUG; Name: Methylphenidate; Assigned to Arm(s): Methylphenidate | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: Pycnogenol; Type: ACTIVE_COMPARATOR; Interventions: Drug: Pycnogenol | Intervention Type: DRUG; Name: Pycnogenol; Assigned to Arm(s): Pycnogenol | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
D: Arm Label: supplement - no retinopathy; Type: EXPERIMENTAL; Interventions: Dietary Supplement: multi-component nutritional supplement capsules | Arm Label: placebo - no retinopathy; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: multi-component dietary supplement | Arm Label: supplement - retinopathy; Type: EXPERIMENTAL; Interventions: Dietary Supplement: multi-component nutritional supplement capsules | Arm Label: placebo - retinopathy; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: multi-component dietary supplement | Intervention Type: DIETARY_SUPPLEMENT; Name: multi-component nutritional supplement capsules; Assigned to Arm(s): supplement - no retinopathy, supplement - retinopathy | Intervention Type: DIETARY_SUPPLEMENT; Name: multi-component dietary supplement; Assigned to Arm(s): placebo - no retinopathy, placebo - retinopathy

Answer: C