TrialPanorama/Dataset huggingface dataset:
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Optimal Prevention of Overdose Deaths and Opioid Relapse Following Discharge: A Multi-Center RCT of Naltrexone Versus Buprenorphine in Norway
Brief Summary: Persons dependent on opioids like heroin, morphine, or codeine have a high risk of relapse, overdose and overdose death. This risk is elevated even further following discharge from treatment or correctional institutions where patients have been detoxified. At the moment, state-of-the-art treatment is based on maintaining the dependence on opioids by daily intake of opioid medications like methadone or buprenorphine. Recently, a medication containing the blocking agent naltrexone was approved in the US; this does not maintain dependence but instead blocks heroin and other opioids for 28 days after intramuscular administration. This study will conduct a 12-week randomized comparison of naltrexone intramuscular suspension (XL-NTX) with daily buprenorphine-naloxone in OMT. Medication will start preceding discharge from a treatment or correctional facility to participating catchment regions in Norway. The main hypotheses are that XL-NTX will do equally well as - or better than - OMT on the proportion of biological samples negative for opioids, retention, self-reported use of alcohol and illicit drugs. Following the 12-week randomized period, there will be a 36-week period where participants can receive the study medication of their choice. After the end of the study, data from national registry databases can be collected for a further 12 months on outcomes such as recidivism, mortality and morbidity.


Options:
A: Arm Label: ICC; Type: EXPERIMENTAL; Interventions: Other: Integrated collaborative care | Arm Label: E&R; Type: ACTIVE_COMPARATOR; Interventions: Other: Education and Resources | Intervention Type: OTHER; Name: Integrated collaborative care; Assigned to Arm(s): ICC | Intervention Type: OTHER; Name: Education and Resources; Assigned to Arm(s): E&R
B: Arm Label: Naltrexone intramuscular suspension; Type: EXPERIMENTAL; Interventions: Drug: Naltrexone intramuscular suspension | Arm Label: Buprenorphine-naloxone; Type: ACTIVE_COMPARATOR; Interventions: Drug: Buprenorphine-naloxone | Intervention Type: DRUG; Name: Naltrexone intramuscular suspension; Assigned to Arm(s): Naltrexone intramuscular suspension | Intervention Type: DRUG; Name: Buprenorphine-naloxone; Assigned to Arm(s): Buprenorphine-naloxone
C: Intervention Type: DRUG; Name: Buprenorphine; Assigned to Arm(s): N/A
D: Arm Label: Buprenorphine/Nx with EMM; Type: EXPERIMENTAL; Interventions: Behavioral: Enhanced Medical Management (EMM) of Prescription Opiate Abuse | Arm Label: Buprenorphine/Nx with SMM; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Standard Medical Management (SMM) of Prescription Opiate Abuse | Intervention Type: BEHAVIORAL; Name: Standard Medical Management (SMM) of Prescription Opiate Abuse; Assigned to Arm(s): Buprenorphine/Nx with SMM | Intervention Type: BEHAVIORAL; Name: Enhanced Medical Management (EMM) of Prescription Opiate Abuse; Assigned to Arm(s): Buprenorphine/Nx with EMM

Answer: B
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Role of Macronutrient Diet Composition on Maternal and Infant Metabolic Outcomes in Gestational Diabetes
Brief Summary: A better understanding of the optimal diet for women with gestational diabetes is fundamental to the management of this rapidly growing problem in pregnancy. Careful comparison studies of the current low- carbohydrate, higher-fat diet versus a diet higher in complex carbohydrate but lower in fat is critical in order to determine which diet results in a more favorable maternal 24-hour glucose, lipid, and inflammatory profile, all of which directly effect optimal fetal growth and may influence the future health of the offspring.


Options:
A: Arm Label: Glyburide (Glyburide vs Insulin); Type: N/A; Interventions: Drug: Glyburide vs Insulin trials | Arm Label: Insulin (Glyburide vs Insulin); Type: N/A; Interventions: Drug: Glyburide vs Insulin trials | Arm Label: Metformin (Metformin vs Insulin); Type: N/A; Interventions: Drug: Metformin vs Insulin trials | Arm Label: Insulin (Metformin vs Insulin); Type: N/A; Interventions: Drug: Metformin vs Insulin trials | Arm Label: Metformin (Metformin vs Glyburide); Type: N/A; Interventions: Drug: Metformin vs Glyburide trials | Arm Label: Glyburide (Metformin vs Glyburide); Type: N/A; Interventions: Drug: Metformin vs Glyburide trials | Intervention Type: DRUG; Name: Glyburide vs Insulin trials; Assigned to Arm(s): Glyburide (Glyburide vs Insulin), Insulin (Glyburide vs Insulin) | Intervention Type: DRUG; Name: Metformin vs Insulin trials; Assigned to Arm(s): Insulin (Metformin vs Insulin), Metformin (Metformin vs Insulin) | Intervention Type: DRUG; Name: Metformin vs Glyburide trials; Assigned to Arm(s): Glyburide (Metformin vs Glyburide), Metformin (Metformin vs Glyburide)
B: Arm Label: Low CHO; Type: EXPERIMENTAL; Interventions: Behavioral: Low CHO | Arm Label: High CHO; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: High CHO diet | Intervention Type: BEHAVIORAL; Name: Low CHO; Assigned to Arm(s): Low CHO | Intervention Type: DIETARY_SUPPLEMENT; Name: High CHO diet; Assigned to Arm(s): High CHO
C: Arm Label: Nutritional counseling & self blood glucose monitoring; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: nutritional counseling, Behavioral: self blood glucose monitoring | Arm Label: No treatment; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: nutritional counseling; Assigned to Arm(s): Nutritional counseling & self blood glucose monitoring | Intervention Type: BEHAVIORAL; Name: self blood glucose monitoring; Assigned to Arm(s): Nutritional counseling & self blood glucose monitoring
D: Arm Label: Conventional Diet; Type: EXPERIMENTAL; Interventions: Other: High Carbohydrate/Low fat diet | Arm Label: Complex Carbohydrate Diet; Type: EXPERIMENTAL; Interventions: Other: Low-Carbohydrate/Higher Fat Diet | Intervention Type: OTHER; Name: Low-Carbohydrate/Higher Fat Diet; Assigned to Arm(s): Complex Carbohydrate Diet | Intervention Type: OTHER; Name: High Carbohydrate/Low fat diet; Assigned to Arm(s): Conventional Diet

Answer: D
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Intrathecal Therapy With Monoclonal Antibodies in Progressive Multiple Sclerosis
Brief Summary: This is a is a small scale open phase two interventional study to assess long-term stabilising effects of on neurological symptoms by regular intrathecal administered monoclonal antibodies in progressive multiple sclerosis.


Options:
A: Intervention Type: DRUG; Name: rituximab; Assigned to Arm(s): N/A
B: Arm Label: Cohort; Type: N/A; Interventions: Biological: Rituximab | Intervention Type: BIOLOGICAL; Name: Rituximab; Assigned to Arm(s): Cohort
C: Arm Label: Rituximab; Type: EXPERIMENTAL; Interventions: Drug: Rituximab | Intervention Type: DRUG; Name: Rituximab; Assigned to Arm(s): Rituximab
D: Arm Label: Rituximab; Type: EXPERIMENTAL; Interventions: Drug: Rituximab | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: normal saline | Arm Label: Baseline; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DRUG; Name: Rituximab; Assigned to Arm(s): Rituximab | Intervention Type: OTHER; Name: normal saline; Assigned to Arm(s): Placebo

Answer: C
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Incidence of Sleep-disordered Breathing and Upper Airway Collapsibility in Postpartum Patients and Its Intervention
Brief Summary: The investigators hypothesized that sleeping in a 45 degrees elevated body position decreases the likelihood of upper airway vulnerability to collapse early after delivery. Furthermore, the investigators want to elucidate the anatomical and physiological risk factors that contribute in the upper airway obstruction in post-partum patients.


Options:
A: Intervention Type: DEVICE; Name: Nasal CPAP (Continuous Positive Airway Pressure); Assigned to Arm(s): N/A
B: Arm Label: Sleep position trainer; Type: EXPERIMENTAL; Interventions: Device: sleep position trainer | Arm Label: Oral Appliance Therapy; Type: ACTIVE_COMPARATOR; Interventions: Device: Oral Appliance Therapy | Intervention Type: DEVICE; Name: sleep position trainer; Assigned to Arm(s): Sleep position trainer | Intervention Type: DEVICE; Name: Oral Appliance Therapy; Assigned to Arm(s): Oral Appliance Therapy
C: Arm Label: Elevated body position; Type: ACTIVE_COMPARATOR; Interventions: Procedure: elevated body position | Arm Label: supine body position; Type: ACTIVE_COMPARATOR; Interventions: Procedure: supine body position | Intervention Type: PROCEDURE; Name: elevated body position; Assigned to Arm(s): Elevated body position | Intervention Type: PROCEDURE; Name: supine body position; Assigned to Arm(s): supine body position
D: Arm Label: SPT in patients with MAD; Type: OTHER; Interventions: Device: Sleep Position Trainer (SPT) | Intervention Type: DEVICE; Name: Sleep Position Trainer (SPT); Assigned to Arm(s): SPT in patients with MAD

Answer: C
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Sequential Segmental Treatment of Emphysema With Upper Lobe Predominance (STEP-UP) Study
Brief Summary: This study is designed to demonstrate safety and efficacy in patients with severe upper lobe predominant emphysema. For validity of the study, the results will be compared to patients that receive optimal medical therapy.


Options:
A: Arm Label: Treatment plus Optimal Medical Therapy; Type: EXPERIMENTAL; Interventions: Device: InterVapor® treatment plus Optimal Medical Therapy | Arm Label: Optimal Medical Therapy; Type: ACTIVE_COMPARATOR; Interventions: Other: Optimal Medical Therapy | Intervention Type: DEVICE; Name: InterVapor® treatment plus Optimal Medical Therapy; Assigned to Arm(s): Treatment plus Optimal Medical Therapy | Intervention Type: OTHER; Name: Optimal Medical Therapy; Assigned to Arm(s): Optimal Medical Therapy
B: Arm Label: Group 1; Type: EXPERIMENTAL; Interventions: Drug: Biologic Lung Volume Reduction (BLVR) - 20 mL Hydrogel | Arm Label: Group 2; Type: EXPERIMENTAL; Interventions: Drug: Biologic Lung Volume Reduction (BLVR) - 20 mL Hydrogel | Intervention Type: DRUG; Name: Biologic Lung Volume Reduction (BLVR) - 20 mL Hydrogel; Assigned to Arm(s): Group 1, Group 2
C: Arm Label: Endobronchial valve:; Type: EXPERIMENTAL; Interventions: Device: Endobronchial valve | Intervention Type: DEVICE; Name: Endobronchial valve; Assigned to Arm(s): Endobronchial valve:
D: Arm Label: Lung volume reduction coïl treatment; Type: EXPERIMENTAL; Interventions: Procedure: Lung volume reduction coïl treatment, Other: Regular medical treatment | Arm Label: Regular Medical Treatment; Type: OTHER; Interventions: Other: Regular medical treatment | Intervention Type: PROCEDURE; Name: Lung volume reduction coïl treatment; Assigned to Arm(s): Lung volume reduction coïl treatment | Intervention Type: OTHER; Name: Regular medical treatment; Assigned to Arm(s): Lung volume reduction coïl treatment, Regular Medical Treatment

Answer: A
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Sequential Segmental Treatment of Emphysema With Upper Lobe Predominance (STEP-UP) Study
Brief Summary: This study is designed to demonstrate safety and efficacy in patients with severe upper lobe predominant emphysema. For validity of the study, the results will be compared to patients that receive optimal medical therapy.


Options:
A: Intervention Type: PROCEDURE; Name: Emphasys Endobronchial Valve and procedure; Assigned to Arm(s): N/A
B: Arm Label: Treatment plus Optimal Medical Therapy; Type: EXPERIMENTAL; Interventions: Device: InterVapor® treatment plus Optimal Medical Therapy | Arm Label: Optimal Medical Therapy; Type: ACTIVE_COMPARATOR; Interventions: Other: Optimal Medical Therapy | Intervention Type: DEVICE; Name: InterVapor® treatment plus Optimal Medical Therapy; Assigned to Arm(s): Treatment plus Optimal Medical Therapy | Intervention Type: OTHER; Name: Optimal Medical Therapy; Assigned to Arm(s): Optimal Medical Therapy
C: Arm Label: BLVR Treatment; Type: EXPERIMENTAL; Interventions: Biological: BLVR Treatment | Intervention Type: BIOLOGICAL; Name: BLVR Treatment; Assigned to Arm(s): BLVR Treatment
D: Arm Label: Group 1; Type: EXPERIMENTAL; Interventions: Drug: Biologic Lung Volume Reduction (BLVR) - 20 mL Hydrogel | Arm Label: Group 2; Type: EXPERIMENTAL; Interventions: Drug: Biologic Lung Volume Reduction (BLVR) - 20 mL Hydrogel | Intervention Type: DRUG; Name: Biologic Lung Volume Reduction (BLVR) - 20 mL Hydrogel; Assigned to Arm(s): Group 1, Group 2

Answer: B
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: EFFECT OF COGNITIVE-BEHAVIORAL THERAPY AND EXERCISE VERSUS SUPERVISED EXERCISE PROGRAM IN PATIENTS WITH CHRONIC PAIN LUMBAR NO SPECIFIC: RANDOMIZED CONTROLLED TRIAL
Brief Summary: The purpose of this study is to compare the efficacy of graded activity program and supervised exercise on pain, functional disability, quality of life, global perceived effect, return to work, physical activity, physical capacity and strength of the lower limbs in patients with chronic non-specific low back pain


Options:
A: Arm Label: Treatment based on Movement System Impairment based model; Type: EXPERIMENTAL; Interventions: Other: Treatment based on Movement System Impairment model | Arm Label: General exercise; Type: ACTIVE_COMPARATOR; Interventions: Other: General exercise | Intervention Type: OTHER; Name: Treatment based on Movement System Impairment model; Assigned to Arm(s): Treatment based on Movement System Impairment based model | Intervention Type: OTHER; Name: General exercise; Assigned to Arm(s): General exercise
B: Intervention Type: PROCEDURE; Name: Mod. functional restoration-Individ. dynamic back-muscle; Assigned to Arm(s): N/A
C: Arm Label: Graded Activity; Type: ACTIVE_COMPARATOR; Interventions: Other: Graded Activity, Other: Supervised Exercises | Arm Label: Supervised exercises; Type: ACTIVE_COMPARATOR; Interventions: Other: Graded Activity, Other: Supervised Exercises | Intervention Type: OTHER; Name: Graded Activity; Assigned to Arm(s): Graded Activity, Supervised exercises | Intervention Type: OTHER; Name: Supervised Exercises; Assigned to Arm(s): Graded Activity, Supervised exercises
D: Arm Label: Core stabilization and psychosocial education; Type: EXPERIMENTAL; Interventions: Behavioral: Core stabilization and psychosocial education | Arm Label: Core stabilization exercise only; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Core stabilization exercise only | Arm Label: Psychosocial education class only.; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Psychosocial education class only | Arm Label: Traditional Army training; Type: OTHER; Interventions: Behavioral: Traditional Army training | Intervention Type: BEHAVIORAL; Name: Traditional Army training; Assigned to Arm(s): Traditional Army training | Intervention Type: BEHAVIORAL; Name: Core stabilization exercise only; Assigned to Arm(s): Core stabilization exercise only | Intervention Type: BEHAVIORAL; Name: Psychosocial education class only; Assigned to Arm(s): Psychosocial education class only. | Intervention Type: BEHAVIORAL; Name: Core stabilization and psychosocial education; Assigned to Arm(s): Core stabilization and psychosocial education

Answer: C
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: EFFECT OF COGNITIVE-BEHAVIORAL THERAPY AND EXERCISE VERSUS SUPERVISED EXERCISE PROGRAM IN PATIENTS WITH CHRONIC PAIN LUMBAR NO SPECIFIC: RANDOMIZED CONTROLLED TRIAL
Brief Summary: The purpose of this study is to compare the efficacy of graded activity program and supervised exercise on pain, functional disability, quality of life, global perceived effect, return to work, physical activity, physical capacity and strength of the lower limbs in patients with chronic non-specific low back pain


Options:
A: Arm Label: TrA exercise; Type: EXPERIMENTAL; Interventions: Behavioral: Isolated Transversus abdominis (TrA) exercise | Arm Label: sling exercise; Type: EXPERIMENTAL; Interventions: Behavioral: sling exercise | Arm Label: group exercise; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: group exercise | Intervention Type: BEHAVIORAL; Name: Isolated Transversus abdominis (TrA) exercise; Assigned to Arm(s): TrA exercise | Intervention Type: BEHAVIORAL; Name: sling exercise; Assigned to Arm(s): sling exercise | Intervention Type: BEHAVIORAL; Name: group exercise; Assigned to Arm(s): group exercise
B: Arm Label: Graded Activity; Type: ACTIVE_COMPARATOR; Interventions: Other: Graded Activity, Other: Supervised Exercises | Arm Label: Supervised exercises; Type: ACTIVE_COMPARATOR; Interventions: Other: Graded Activity, Other: Supervised Exercises | Intervention Type: OTHER; Name: Graded Activity; Assigned to Arm(s): Graded Activity, Supervised exercises | Intervention Type: OTHER; Name: Supervised Exercises; Assigned to Arm(s): Graded Activity, Supervised exercises
C: Intervention Type: PROCEDURE; Name: Mod. functional restoration-Individ. dynamic back-muscle; Assigned to Arm(s): N/A
D: Arm Label: Treatment based on Movement System Impairment based model; Type: EXPERIMENTAL; Interventions: Other: Treatment based on Movement System Impairment model | Arm Label: General exercise; Type: ACTIVE_COMPARATOR; Interventions: Other: General exercise | Intervention Type: OTHER; Name: Treatment based on Movement System Impairment model; Assigned to Arm(s): Treatment based on Movement System Impairment based model | Intervention Type: OTHER; Name: General exercise; Assigned to Arm(s): General exercise

Answer: B
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Conmana Versus Pemetrexed-based First-line Induction and Maintenance Chemotherapy in Advanced Lung Adenocarcinoma With EGFR-mutation
Brief Summary: The purpose of this study is to compare icotinib with induction and maintenance chemotherapy in the first-line treatment of advanced non-small cell lung cancer (NSCLC) patients with EGFR mutation.


Options:
A: Arm Label: Cetuximab plus chemotherapy; Type: EXPERIMENTAL; Interventions: Drug: cetuximab + cisplatin + vinorelbine | Arm Label: Chemotherapy alone; Type: ACTIVE_COMPARATOR; Interventions: Drug: cisplatin + vinorelbine | Intervention Type: DRUG; Name: cetuximab + cisplatin + vinorelbine; Assigned to Arm(s): Cetuximab plus chemotherapy | Intervention Type: DRUG; Name: cisplatin + vinorelbine; Assigned to Arm(s): Chemotherapy alone
B: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: Gefitinib | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Drug: Carboplatin, Drug: Paclitaxel | Intervention Type: DRUG; Name: Gefitinib; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Carboplatin; Assigned to Arm(s): 2 | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): 2
C: Arm Label: Icotinib; Type: EXPERIMENTAL; Interventions: Drug: Icotinib | Arm Label: Chemotherapy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Chemotherapy | Intervention Type: DRUG; Name: Icotinib; Assigned to Arm(s): Icotinib | Intervention Type: DRUG; Name: Chemotherapy; Assigned to Arm(s): Chemotherapy
D: Arm Label: erlotinib; Type: EXPERIMENTAL; Interventions: Drug: erlotinib | Arm Label: gemcitabine/carboplatin; Type: ACTIVE_COMPARATOR; Interventions: Drug: gemcitabine/carboplatin | Intervention Type: DRUG; Name: erlotinib; Assigned to Arm(s): erlotinib | Intervention Type: DRUG; Name: gemcitabine/carboplatin; Assigned to Arm(s): gemcitabine/carboplatin

Answer: C
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Psychoeducation of Borderline Patients
Brief Summary: Recent research suggests that BPD is a common, serious but treatable disorder with a better than previously recognized prognosis. Despite these findings, many patients with BPD are not given the borderline diagnosis by the mental health professionals treating them. It is also true that many newly diagnosed borderline patients are not provided with up-to-date information on the disorder even though psychoeducation has been found to be a useful form of treatment for other serious psychiatric illnesses.

The investigators have conducted a preliminary randomized trial of psychoeducation for BPD that found that those provided with immediate psychoeducation had a significantly greater reduction in two core symptoms of BPD--general impulsivity and stormy relationships--than those with delayed psychoeducation.

However, both instruction and assessment of change over time were conducted in person by paraprofessionals. The importance of the current study is that it will allow the investigators to develop and test the efficacy of an internet-based program of psychoeducation for BPD that will be both cost efficient and easy to disseminate widely, particularly to underserved populations.


Options:
A: Arm Label: COPESS and Treatment as usual; Type: ACTIVE_COMPARATOR; Interventions: Other: COPESS | Arm Label: Treatment as usual only; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: OTHER; Name: COPESS; Assigned to Arm(s): COPESS and Treatment as usual
B: Arm Label: Mindfulness; Type: EXPERIMENTAL; Interventions: Behavioral: Mindfulness | Arm Label: Interpersonal effectiveness; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: interpersonal effectiveness | Intervention Type: BEHAVIORAL; Name: Mindfulness; Assigned to Arm(s): Mindfulness | Intervention Type: BEHAVIORAL; Name: interpersonal effectiveness; Assigned to Arm(s): Interpersonal effectiveness
C: Arm Label: Non-Education; Type: PLACEBO_COMPARATOR; Interventions: Behavioral: Non-Education | Arm Label: Education; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Education | Intervention Type: BEHAVIORAL; Name: Education; Assigned to Arm(s): Education | Intervention Type: BEHAVIORAL; Name: Non-Education; Assigned to Arm(s): Non-Education
D: Arm Label: TAU w/ mobile app + volunteer support; Type: EXPERIMENTAL; Interventions: Behavioral: Volunteer support, Other: Mobile app | Arm Label: TAU w/ mobile app engagement; Type: EXPERIMENTAL; Interventions: Other: Mobile app | Arm Label: Treatment as Usual (TAU); Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: Volunteer support; Assigned to Arm(s): TAU w/ mobile app + volunteer support | Intervention Type: OTHER; Name: Mobile app; Assigned to Arm(s): TAU w/ mobile app + volunteer support, TAU w/ mobile app engagement

Answer: C