Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized Phase III Study of Temozolomide and Short-Course Radiation Versus Short-Course Radiation Alone In The Treatment of Newly Diagnosed Glioblastoma Multiforme in Elderly Patients
Brief Summary: RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with temozolomide may kill more tumor cells. It is not yet known whether radiation therapy and temozolomide are more effective than radiation therapy alone in treating glioblastoma multiforme.

PURPOSE: This randomized phase III trial is studying radiation therapy and temozolomide to see how well they work compared with radiation therapy alone in treating patients with newly diagnosed glioblastoma multiforme.


Options:
A: Arm Label: Cediranib 30mg; Type: EXPERIMENTAL; Interventions: Drug: Cediranib | Arm Label: Cediranib 20mg + lomustine; Type: OTHER; Interventions: Drug: Cediranib, Drug: Lomustine Chemotherapy | Arm Label: Lomustine and Placebo Cediranib; Type: ACTIVE_COMPARATOR; Interventions: Drug: Lomustine Chemotherapy, Drug: Placebo Cediranib | Intervention Type: DRUG; Name: Cediranib; Assigned to Arm(s): Cediranib 30mg | Intervention Type: DRUG; Name: Cediranib; Assigned to Arm(s): Cediranib 20mg + lomustine | Intervention Type: DRUG; Name: Lomustine Chemotherapy; Assigned to Arm(s): Cediranib 20mg + lomustine, Lomustine and Placebo Cediranib | Intervention Type: DRUG; Name: Placebo Cediranib; Assigned to Arm(s): Lomustine and Placebo Cediranib
B: Arm Label: ARM A - Regorafenib; Type: EXPERIMENTAL; Interventions: Drug: Regorafenib | Arm Label: ARM B - Lomustine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Lomustine | Intervention Type: DRUG; Name: Regorafenib; Assigned to Arm(s): ARM A - Regorafenib | Intervention Type: DRUG; Name: Lomustine; Assigned to Arm(s): ARM B - Lomustine
C: Arm Label: Control; Type: ACTIVE_COMPARATOR; Interventions: Drug: Alkylating Agents | Arm Label: Experimental; Type: EXPERIMENTAL; Interventions: Drug: Disulfiram, Dietary Supplement: Copper, Drug: Alkylating Agents | Intervention Type: DRUG; Name: Disulfiram; Assigned to Arm(s): Experimental | Intervention Type: DIETARY_SUPPLEMENT; Name: Copper; Assigned to Arm(s): Experimental | Intervention Type: DRUG; Name: Alkylating Agents; Assigned to Arm(s): Control, Experimental
D: Arm Label: Temozolomide; Type: ACTIVE_COMPARATOR; Interventions: Drug: temozolomide, Genetic: DNA methylation analysis, Procedure: quality-of-life assessment | Arm Label: Radiation; Type: ACTIVE_COMPARATOR; Interventions: Genetic: DNA methylation analysis, Procedure: quality-of-life assessment, Radiation: Radiation | Intervention Type: DRUG; Name: temozolomide; Assigned to Arm(s): Temozolomide | Intervention Type: GENETIC; Name: DNA methylation analysis; Assigned to Arm(s): Radiation, Temozolomide | Intervention Type: PROCEDURE; Name: quality-of-life assessment; Assigned to Arm(s): Radiation, Temozolomide | Intervention Type: RADIATION; Name: Radiation; Assigned to Arm(s): Radiation

Answer: D