Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Per Operative Fluid Optimisation Comparison of an Automated Closed-Loop System Versus Current Practice in High Risk Abdominal Surgical Patient. A Prospective, Randomized Clinical Trial.
Brief Summary: Dynamic parameters like pulse pressure variation have been shown to be accurate predictors of fluid responsiveness. Hemodynamic optimization based on fluid management and stroke volume optimization have been shown to improve patient outcomes, especially for moderate and high risk abdominal surgical patients. A novel closed-loop fluid administration system based on multi-parameter hemodynamic monitoring have been described recently. This prospective, randomized, surgeon and patient blinded study aims at comparing the cardiac output provided by either this closed-loop system or the anesthesiologist team in high-rish surgical patient elected for abdominal surgery at Pierre Bénite University Hospital, Hospices Civils of Lyon, France. Primary endpoint is the mean indexed cardiac output during surgery per group. We will also compare hemodynamic parameter (cardiac output, stroke volume, blood pressure heart rate...) and patient's outcomes (morbidity, mortality, transfusion rate, hospital length of stay) between groups


Options:
A: Arm Label: Automated fluid management system (Closed-loop system); Type: EXPERIMENTAL; Interventions: Device: Closed loop automated System (LIR®: learning intravenous resuscitator) | Arm Label: Current practice manual fluid management; Type: SHAM_COMPARATOR; Interventions: Device: manual current practice by anesthesiologist team | Intervention Type: DEVICE; Name: Closed loop automated System (LIR®: learning intravenous resuscitator); Assigned to Arm(s): Automated fluid management system (Closed-loop system) | Intervention Type: DEVICE; Name: manual current practice by anesthesiologist team; Assigned to Arm(s): Current practice manual fluid management
B: Arm Label: Goal directed fluid therapy using esophageal doppler monitor; Type: ACTIVE_COMPARATOR; Interventions: Device: Esophageal Doppler Monitor | Arm Label: Fluid therapy using standard management; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DEVICE; Name: Esophageal Doppler Monitor; Assigned to Arm(s): Goal directed fluid therapy using esophageal doppler monitor
C: Arm Label: Intervention; Type: EXPERIMENTAL; Interventions: Other: Fluid titrated with the use of arterial pulse contour cardiac output monitor if SVV >13% | Arm Label: Control; Type: ACTIVE_COMPARATOR; Interventions: Other: Fluid titrated at the discretion of the attending anesthesiologist | Intervention Type: OTHER; Name: Fluid titrated with the use of arterial pulse contour cardiac output monitor if SVV >13%; Assigned to Arm(s): Intervention | Intervention Type: OTHER; Name: Fluid titrated at the discretion of the attending anesthesiologist; Assigned to Arm(s): Control
D: Arm Label: Closed-loop GDFT; Type: EXPERIMENTAL; Interventions: Device: Closed-Loop GDFT | Arm Label: Restrictive fluid therapy; Type: ACTIVE_COMPARATOR; Interventions: Other: Restrictive Fluid Therapy | Intervention Type: DEVICE; Name: Closed-Loop GDFT; Assigned to Arm(s): Closed-loop GDFT | Intervention Type: OTHER; Name: Restrictive Fluid Therapy; Assigned to Arm(s): Restrictive fluid therapy

Answer: A