Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Misoprostol in the Treatment of Post Partum Hemorrhage: A Placebo Randomised Controlled Trial in 4 Karachi Hospitals
Brief Summary: Postpartum haemorrhage (PPH) remains a leading cause of maternal mortality, despite treatment with conventional methods. Uncontrolled reports and three small randomised controlled trials have suggested that misoprostol may have an additive effect to routine treatment, and there is a serious danger that this method will be used widely without research to document the effectiveness or risks of this method. In this randomised controlled trial (RCT), we propose to test whether 600 μg of sublingually administered misoprostol in women requiring additional uterotonics after delivery, and after routine syntocinon to all women during or after delivery, has additional effects above the additional conventional uterotonics in reducing PPH. Women with measured blood loss greater than or equal to 500 mls in 4 Karachi hospitals who give consent will be given locally routine treatment for PPH. In addition, they will be enrolled by drawing the next of a series of randomised treatment packs containing misoprostol or placebo. The primary outcome measure will be blood loss greater than or equal to 500 mls after enrolment.


Options:
A: Arm Label: Intervention; Type: EXPERIMENTAL; Interventions: Behavioral: Community Engagement, Device: PIERS on the Move mHealth decision aid, Drug: Magnesium Sulfate, Drug: Methyldopa | Arm Label: Control; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: Community Engagement; Assigned to Arm(s): Intervention | Intervention Type: DEVICE; Name: PIERS on the Move mHealth decision aid; Assigned to Arm(s): Intervention | Intervention Type: DRUG; Name: Magnesium Sulfate; Assigned to Arm(s): Intervention | Intervention Type: DRUG; Name: Methyldopa; Assigned to Arm(s): Intervention
B: Arm Label: Misoprostol; Type: EXPERIMENTAL; Interventions: Drug: Misoprostol | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Misoprostol | Intervention Type: DRUG; Name: Misoprostol; Assigned to Arm(s): Misoprostol, Placebo
C: Arm Label: Misoprostol; Type: EXPERIMENTAL; Interventions: Drug: Misoprostol | Arm Label: Oxytocin; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oxytocin | Intervention Type: DRUG; Name: Misoprostol; Assigned to Arm(s): Misoprostol | Intervention Type: DRUG; Name: Oxytocin; Assigned to Arm(s): Oxytocin
D: Arm Label: Full - Train/oxy&miso/ B&M/Mentor/Phone; Type: EXPERIMENTAL; Interventions: Other: Helping Mothers Survive - Bleeding After Birth training, Other: Helping Babies Breathe, Behavioral: Mentor, Behavioral: Phone, Drug: oxytocin and misoprostol, Device: Newborn bag and mask | Arm Label: Partial - Train/oxy & miso/ B&M/Mentor; Type: EXPERIMENTAL; Interventions: Other: Helping Mothers Survive - Bleeding After Birth training, Other: Helping Babies Breathe, Behavioral: Mentor, Drug: oxytocin and misoprostol, Device: Newborn bag and mask | Arm Label: Comparison - Train/oxy & miso/ B&M; Type: ACTIVE_COMPARATOR; Interventions: Other: Helping Mothers Survive - Bleeding After Birth training, Other: Helping Babies Breathe, Drug: oxytocin and misoprostol, Device: Newborn bag and mask | Intervention Type: OTHER; Name: Helping Mothers Survive - Bleeding After Birth training; Assigned to Arm(s): Comparison - Train/oxy & miso/ B&M, Full - Train/oxy&miso/ B&M/Mentor/Phone, Partial - Train/oxy & miso/ B&M/Mentor | Intervention Type: OTHER; Name: Helping Babies Breathe; Assigned to Arm(s): Comparison - Train/oxy & miso/ B&M, Full - Train/oxy&miso/ B&M/Mentor/Phone, Partial - Train/oxy & miso/ B&M/Mentor | Intervention Type: BEHAVIORAL; Name: Mentor; Assigned to Arm(s): Full - Train/oxy&miso/ B&M/Mentor/Phone, Partial - Train/oxy & miso/ B&M/Mentor | Intervention Type: BEHAVIORAL; Name: Phone; Assigned to Arm(s): Full - Train/oxy&miso/ B&M/Mentor/Phone | Intervention Type: DRUG; Name: oxytocin and misoprostol; Assigned to Arm(s): Comparison - Train/oxy & miso/ B&M, Full - Train/oxy&miso/ B&M/Mentor/Phone, Partial - Train/oxy & miso/ B&M/Mentor | Intervention Type: DEVICE; Name: Newborn bag and mask; Assigned to Arm(s): Comparison - Train/oxy & miso/ B&M, Full - Train/oxy&miso/ B&M/Mentor/Phone, Partial - Train/oxy & miso/ B&M/Mentor

Answer: B