Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Multicentre 3 Year Longitudinal Prospective Study to Identify Novel Endpoints and Compare These With Forced Expiratory Volume in 1 Second (FEV1) for Their Ability to Measure and Predict COPD Severity and Its Progression Over Time
Brief Summary: This is a 3 year longitudinal study to identify novel endpoints and compare these with standard measures such as forced expiratory volume in 1 second (FEV1) for their ability to measure and predict COPD (Chronic Obstructive Pulmonary Disease) severity and its progression over time. Control subjects (smokers and never smokers) will be recruited as comparators with the COPD subjects.


Options:
A: Arm Label: UMEC/VI arm; Type: EXPERIMENTAL; Interventions: Drug: UMEC/VI, Drug: UMEC/VI matching placebo, Drug: Albuterol/salbutamol Metered Dose Inhaler (MDI) | Arm Label: Tiotropium + Indacaterol arm; Type: PLACEBO_COMPARATOR; Interventions: Drug: Tiotropium, Drug: Tiotropium matching placebo, Drug: Indacaterol, Drug: Indacaterol matching placebo, Drug: Albuterol/salbutamol Metered Dose Inhaler (MDI) | Intervention Type: DRUG; Name: UMEC/VI; Assigned to Arm(s): UMEC/VI arm | Intervention Type: DRUG; Name: UMEC/VI matching placebo; Assigned to Arm(s): UMEC/VI arm | Intervention Type: DRUG; Name: Tiotropium; Assigned to Arm(s): Tiotropium + Indacaterol arm | Intervention Type: DRUG; Name: Tiotropium matching placebo; Assigned to Arm(s): Tiotropium + Indacaterol arm | Intervention Type: DRUG; Name: Indacaterol; Assigned to Arm(s): Tiotropium + Indacaterol arm | Intervention Type: DRUG; Name: Indacaterol matching placebo; Assigned to Arm(s): Tiotropium + Indacaterol arm | Intervention Type: DRUG; Name: Albuterol/salbutamol Metered Dose Inhaler (MDI); Assigned to Arm(s): Tiotropium + Indacaterol arm, UMEC/VI arm
B: Arm Label: COPD subjects; Type: N/A; Interventions: Other: Novel endpoint determination | Arm Label: Smoker controls; Type: N/A; Interventions: Other: Novel endpoint determination | Arm Label: Non-smoker controls; Type: N/A; Interventions: Other: Novel endpoint determination | Intervention Type: OTHER; Name: Novel endpoint determination; Assigned to Arm(s): COPD subjects, Non-smoker controls, Smoker controls
C: Arm Label: UMEC (62.5 mcg); Type: EXPERIMENTAL; Interventions: Drug: UMEC DPI, Drug: ICS/LABA medication, Drug: Albuterol/salbutamol Metered Dose Inhaler (MDI) | Arm Label: Placebo; Type: EXPERIMENTAL; Interventions: Drug: Placebo DPI, Drug: ICS/LABA medication, Drug: Albuterol/salbutamol Metered Dose Inhaler (MDI) | Intervention Type: DRUG; Name: UMEC DPI; Assigned to Arm(s): UMEC (62.5 mcg) | Intervention Type: DRUG; Name: Placebo DPI; Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: ICS/LABA medication; Assigned to Arm(s): Placebo, UMEC (62.5 mcg) | Intervention Type: DRUG; Name: Albuterol/salbutamol Metered Dose Inhaler (MDI); Assigned to Arm(s): Placebo, UMEC (62.5 mcg)
D: Arm Label: Active; Type: EXPERIMENTAL; Interventions: Drug: 100mcg | Arm Label: Active 2; Type: EXPERIMENTAL; Interventions: Drug: 500mcg | Arm Label: Active 3; Type: EXPERIMENTAL; Interventions: Drug: 1000mcg | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: 100mcg; Assigned to Arm(s): Active | Intervention Type: DRUG; Name: 500mcg; Assigned to Arm(s): Active 2 | Intervention Type: DRUG; Name: 1000mcg; Assigned to Arm(s): Active 3 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo

Answer: B