Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Testosterone Dose Response in Surgically Menopausal Women
Brief Summary: TDSM will study the physiology of testosterone in women ages 21-60 who have had surgical menopause (uterus and both ovaries removed). Testosterone is commonly thought of as a "male hormone" thus being that it is the male's primary hormone. Women produce testosterone in much smaller amounts and despite this, testosterone still plays a significant role. Fifty percent of a women's testosterone is made in her adrenal glands (glands that sit on top of the kidneys) and fifty percent is made in her ovaries. When a woman has her ovaries removed it is thought that her testosterone levels decrease rapidly and significantly. This study will be examining testosterone's role in sexual function, general well being, muscle performance, cognitive function, carbohydrate metabolism and muscle and fat distribution.

The study is 14 months long with weekly to monthly visits. The subjects will be placed on the estrogen patch for the duration of the study. They will also be given weekly injections of testosterone or placebo for 6 months. During the testosterone treatment phase the women will be separated into 5 groups. The groups include a dose of testosterone that is very low, low, medium, high and placebo. A placebo looks and feels similar to testosterone; however it does not have testosterone in it. We use this to test if the subject is having a response to the testosterone itself or the thought of receiving testosterone. Neither the subject nor the investigators will know the dose until the end of the study.


Options:
A: Arm Label: Brief; Type: EXPERIMENTAL; Interventions: Behavioral: Brief FOCUS Program | Arm Label: Extensive; Type: EXPERIMENTAL; Interventions: Behavioral: Extensive FOCUS Program | Arm Label: Control; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: Brief FOCUS Program; Assigned to Arm(s): Brief | Intervention Type: BEHAVIORAL; Name: Extensive FOCUS Program; Assigned to Arm(s): Extensive
B: Arm Label: Topical liquid lidocaine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Topical liquid lidocaine, Drug: Topical saline | Arm Label: Topical Saline; Type: PLACEBO_COMPARATOR; Interventions: Drug: Topical liquid lidocaine, Drug: Topical saline | Intervention Type: DRUG; Name: Topical liquid lidocaine; Assigned to Arm(s): Topical Saline, Topical liquid lidocaine | Intervention Type: DRUG; Name: Topical saline; Assigned to Arm(s): Topical Saline, Topical liquid lidocaine
C: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Drug: Testosterone | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Drug: Testosterone | Arm Label: 3; Type: ACTIVE_COMPARATOR; Interventions: Drug: Testosterone | Arm Label: 4; Type: ACTIVE_COMPARATOR; Interventions: Drug: Testosterone | Arm Label: 5; Type: ACTIVE_COMPARATOR; Interventions: Drug: Testosterone | Intervention Type: DRUG; Name: Testosterone; Assigned to Arm(s): 1, 2, 3, 4, 5
D: Arm Label: Minimal intervention control group; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Internet-based cognitive behavioral therapy; Type: EXPERIMENTAL; Interventions: Behavioral: Internet-based cognitive behavioral therapy. | Intervention Type: BEHAVIORAL; Name: Internet-based cognitive behavioral therapy.; Assigned to Arm(s): Internet-based cognitive behavioral therapy

Answer: C