Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Manipulating the Microbiome in IBD by Antibiotics and Fecal Microbiota Transplantation (FMT): a Randomized Controlled Trial
Brief Summary: the etiology of Inflammatory Bowel Diseases (IBD) is closely associated with the gut microbiome. The results of previous studies on the effectiveness of antibiotics and fecal macrobiota transplantation (FMT) are contradicting.

Aims: to evaluate the effectiveness of wide-spectrum antibiotic regimens in acute severe colitis in an addition to standard corticosteroid therapy (UC and isolated "UC-like" Crohn's colitis). The secondary aim is to assess the outcome of FMT in those not responding to five days of therapy (in either arm). As an exploratory aim, any IBD patient with a resistant disease to at least two immunosuppressive medications, may be treated with either interventions.


Options:
A: Arm Label: Azithromycin + Metronidazole; Type: EXPERIMENTAL; Interventions: Drug: Azithromycin + Metronidazole | Arm Label: Metronidazole; Type: ACTIVE_COMPARATOR; Interventions: Drug: Metronidazole | Intervention Type: DRUG; Name: Azithromycin + Metronidazole; Assigned to Arm(s): Azithromycin + Metronidazole | Intervention Type: DRUG; Name: Metronidazole; Assigned to Arm(s): Metronidazole
B: Arm Label: Weekly SER-287, after Placebo Pre-Treat.; Type: EXPERIMENTAL; Interventions: Drug: SER-287, Drug: Placebo Pre-Treat | Arm Label: Daily placebo, after Placebo Pre-Treat.; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Drug: Placebo Pre-Treat | Arm Label: Daily SER-287, after Vanco. Pre-Treat.; Type: EXPERIMENTAL; Interventions: Drug: SER-287, Drug: Vancomycin Pre-Treat | Arm Label: Weekly SER-287, after Vanco. Pre-Treat.; Type: EXPERIMENTAL; Interventions: Drug: SER-287, Drug: Vancomycin Pre-Treat | Intervention Type: DRUG; Name: SER-287; Assigned to Arm(s): Daily SER-287, after Vanco. Pre-Treat., Weekly SER-287, after Placebo Pre-Treat., Weekly SER-287, after Vanco. Pre-Treat. | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Daily placebo, after Placebo Pre-Treat. | Intervention Type: DRUG; Name: Placebo Pre-Treat; Assigned to Arm(s): Daily placebo, after Placebo Pre-Treat., Weekly SER-287, after Placebo Pre-Treat. | Intervention Type: DRUG; Name: Vancomycin Pre-Treat; Assigned to Arm(s): Daily SER-287, after Vanco. Pre-Treat., Weekly SER-287, after Vanco. Pre-Treat.
C: Arm Label: Antibiotics in addition to steroids; Type: EXPERIMENTAL; Interventions: Drug: AB (antibiotics) | Arm Label: Steroids only; Type: ACTIVE_COMPARATOR; Interventions: Drug: CS (corticosteroids) Only | Arm Label: Open arm; Type: OTHER; Interventions: Drug: AB (antibiotics), Drug: CS (corticosteroids) Only | Intervention Type: DRUG; Name: AB (antibiotics); Assigned to Arm(s): Antibiotics in addition to steroids, Open arm | Intervention Type: DRUG; Name: CS (corticosteroids) Only; Assigned to Arm(s): Open arm, Steroids only
D: Arm Label: Antibiotic; Type: EXPERIMENTAL; Interventions: Drug: Ceftriaxone, Drug: Metronidazole | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo infusion | Intervention Type: DRUG; Name: Ceftriaxone; Assigned to Arm(s): Antibiotic | Intervention Type: DRUG; Name: Metronidazole; Assigned to Arm(s): Antibiotic | Intervention Type: OTHER; Name: Placebo infusion; Assigned to Arm(s): Placebo

Answer: C