Please select the eligibility criteria that correspond to the clinical trial below.
Title: Family-Based Prevention of Mental Health Problems in HIV/AIDS-Affected Children (R34MH084679-01A1)
Brief Summary: The research will examine the following Specific Aims:

Specific Aim 1: To adapt a U.S.-developed family-focused and strengths-based prevention program to the context of HIV/AIDS-affected families in Rwanda (the Family-Strengthening Intervention in Rwanda or "FSI-R") using prior qualitative findings and CAB input.

Specific Aim 2: To deliver the intervention to a small group of families to collect preliminary data on intervention feasibility, acceptability, and to further refine the intervention manual for the FSI-R.

Specific Aim 3: To conduct a pilot feasibility study of the FSI-R with 80 families.

In pursuit of Specific Aim 3, this research will (a) conduct a preliminary exploratory analysis to examine the extent to which the FSI-R for HIV/AIDS-affected families is associated with improved caregiver-child relationships using measures of family connectedness, good parenting, and social support. Hypothesis 1: Participants in the FSI-R will demonstrate increases in protective processes compared to usual care controls not exposed to the FSI-R. It will also (b) conduct a preliminary exploratory analysis to determine the extent to which improved caregiver-child relationships are sustained four months after the conclusion of the FSI-R. Hypothesis 2: Four months after the conclusion of the intervention, participants in the FSI-R will demonstrate increases in protective processes compared to usual care controls not exposed to the FSI-R.


Options:
A: Inclusion Criteria:

* Community Health Workers working in the randomized clinics, Portuguese speakers

Exclusion Criteria:

* Other clinic staff from this clinics or other clinics
B: Inclusion criteria: All participants must be HIV/AIDS-affected (i.e., having an HIV+ family member, including those who have died). We will select single and dual caregiver families to reflect population dynamics in the area. Caregivers must be at least 18 years of age (the age of majority in Rwanda), must live in the same household as the children, and must be the child's legal guardian. Legal guardians may be aunts, uncles, grandparents, or foster parents. Caregivers must be willing to discuss HIV/AIDS with school-aged children in the family.

Exclusion Criteria: Potential participants will be excluded if they do not live in the Rwinkwavu catchment area. Untreated mental illness or active suicidal ideation/attempts in the family also constitutes exclusion criteria (mental health treatment for these problems may occur in conjunction with the FSI). HIV-positive children are ineligible for the study if their HIV status has not been disclosed to them. Exclusion criteria also include lack of caregiver willingness to discuss HIV/AIDS with school-aged children in the family. Youth-headed households will be excluded due to concerns about youth caregivers' capacity to participate in the FSI in addition to other caretaking duties.
C: Inclusion Criteria:

* Parents or primary caregivers (age 18 or above) of children ages 3-7 enrolled in kindergarten
* Resident in one of five study sites

Exclusion Criteria:

* Severe cognitive disability of caregiver affecting ability to provide informed consent
D: Inclusion Criteria:

1. Obesity (BMI \> 40 kg/m2)
2. Age: 18-65

Exclusion Criteria:

1. Diagnosis of obesity secondary to primary endocrine or systemic disease (e.g. Cushing's syndrome)
2. Evidence of clinically relevant thyroid disease
3. Chronic systematic inflammatory disease (e.g. rheumatoid arthritis)
4. Pregnancy
5. Treatment with anti-inflammatory drugs (e.g. corticosteroids)
6. Type 1 diabetes mellitus

Answer: B