Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Prospective Cluster Randomized Controlled Evaluation of the Impact of Zinc and / or Micronutrient Supplementation on Intestinal Flora, Diarrheal Disease Burden, Intestinal Mucosal Integrity and Growth Among Cohorts of Children in Pakistan
Brief Summary: Information on the mechanisms of zinc is still in developing phase. Ecological and biological implications of long term zinc supplementation at population level requires assessment. The trial aims to assess the impact of routine supplementation of zinc among young growing children and evaluate its impact on intestinal microbial flora and relationship with gut mucosa integrity and co-morbidities.


Options:
A: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: Zinc and vitamin A single dose at enrollment | Arm Label: 2; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo and vitamin A single dose at enrollment | Intervention Type: DRUG; Name: Zinc and vitamin A single dose at enrollment; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Placebo and vitamin A single dose at enrollment; Assigned to Arm(s): 2
B: Arm Label: 1. Standard MNP; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Standard MNP | Arm Label: 2. High zinc, low iron MNP; Type: EXPERIMENTAL; Interventions: Dietary Supplement: High zinc, low iron MNP | Arm Label: 3. High zinc, low/no iron; Type: EXPERIMENTAL; Interventions: Dietary Supplement: High zinc, low/no iron on alternating days | Arm Label: 4. Dispersible zinc supplement; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Dispersible zinc supplement | Arm Label: 5. Intermittent zinc supplement; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Intermittent zinc supplement | Arm Label: 6. Placebo powder; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo powder | Intervention Type: DIETARY_SUPPLEMENT; Name: Standard MNP; Assigned to Arm(s): 1. Standard MNP | Intervention Type: DIETARY_SUPPLEMENT; Name: High zinc, low iron MNP; Assigned to Arm(s): 2. High zinc, low iron MNP | Intervention Type: DIETARY_SUPPLEMENT; Name: High zinc, low/no iron on alternating days; Assigned to Arm(s): 3. High zinc, low/no iron | Intervention Type: DIETARY_SUPPLEMENT; Name: Dispersible zinc supplement; Assigned to Arm(s): 4. Dispersible zinc supplement | Intervention Type: DIETARY_SUPPLEMENT; Name: Intermittent zinc supplement; Assigned to Arm(s): 5. Intermittent zinc supplement | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo powder; Assigned to Arm(s): 6. Placebo powder
C: Arm Label: A; Type: ACTIVE_COMPARATOR; Interventions: Other: Nutritional Counselling and Education | Arm Label: B; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Micronutrient Supplementation without Zinc | Arm Label: C; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Micronutrient Supplementation with Zinc | Intervention Type: DIETARY_SUPPLEMENT; Name: Micronutrient Supplementation without Zinc; Assigned to Arm(s): B | Intervention Type: DIETARY_SUPPLEMENT; Name: Micronutrient Supplementation with Zinc; Assigned to Arm(s): C | Intervention Type: OTHER; Name: Nutritional Counselling and Education; Assigned to Arm(s): A
D: Arm Label: Daily preventive Zn; placebo treatment; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Daily preventive Zn; placebo treatment | Arm Label: Therapeutic Zn; daily placebo; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Therapeutic Zn; daily placebo | Arm Label: Intermittent Zn; placebo treatment; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Intermittent Zn; placebo treatment | Arm Label: Surveillance control group; Type: ACTIVE_COMPARATOR; Interventions: Other: Surveillance control group | Arm Label: Non-intervention; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DIETARY_SUPPLEMENT; Name: Daily preventive Zn; placebo treatment; Assigned to Arm(s): Daily preventive Zn; placebo treatment | Intervention Type: DIETARY_SUPPLEMENT; Name: Therapeutic Zn; daily placebo; Assigned to Arm(s): Therapeutic Zn; daily placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: Intermittent Zn; placebo treatment; Assigned to Arm(s): Intermittent Zn; placebo treatment | Intervention Type: OTHER; Name: Surveillance control group; Assigned to Arm(s): Surveillance control group

Answer: C