Please select the eligibility criteria that correspond to the clinical trial below.
Title: Evaluation of a Novel Long Lasting Insecticidal Net and Indoor Residual Spray Product, Separately and Together, Against Malaria Transmitted by Pyrethroid Resistant Mosquitoes.
Brief Summary: The proposed study is a four-arm randomized control trial (RCT) in 48 villages in the Lakes region in Tanzania comparing the relative effectiveness of 4 vector control interventions for reducing malaria transmission and controlling vector populations in an area where An gambiae s.s is pyrethroid and carbamate resistant: 1/ a standard long lasting insecticidal net (LLIN), 2/ a LLIN which incorporates a piperonyl butoxide (PBO) synergist, 3/ a long lasting indoor residual spray (IRS) formulation used in conjunction with standard pyrethroid LLIN or 4/ the long lasting indoor residual spray (IRS) formulation used in conjunction with the LLIN which incorporates a PBO synergist.

The trial will provide epidemiological, entomological, economic and social evidence of impact, as the investigators shall be measuring the reductions in malaria prevalence and malaria transmission rates EIR, and changes in the frequency of resistance, mosquito species ratios and economic cost effectiveness. The proposed trial will demonstrate whether the novel LLIN and long lasting IRS formulation will be more effective for controlling An.gambiae s.s. and reducing malaria prevalence than current practice with the conventional LLIN. There is great interest in conducting this trial. Alternative vector control products are limited and most new insecticides are not suitable for use on LLINs or as IRS.


Options:
A: Household inclusion criteria:

* Households with residents at the time of survey
* Agreement of the adult resident to provide informed consent for the intervention and survey

Study subjects inclusion criteria:

* Passive case detection by health facilities will include all residents in the study clusters; active case detection will include residents of \>6 months
* Agreement of parent/guardian to provide informed consent and minors to provide assent.

Household exclusion criteria:

* Household vacant
* No adult resident home on more than 3 occasions

Study subjects exclusion criteria:

• Participants not home on day of survey
B: Inclusion Criteria:

For the Household

* Having a children from 6 months to 14 years old in the household
* Provide written consent For the children
* Having between 6 months to 14 years
* Permanent residence in a selected household

Exclusion Criteria:

* Children severely ill
C: Inclusion Criteria:

* Individuals who consent to participate in the study
* Residents in the study area
* Older than 6 months of age (or weighing more than 5Kg)
* Women in the second or third trimester who are not on IPTp

Exclusion Criteria:

* Individuals who do not consent to participate in the study
* Younger than 6 months of age (or weighing more than 5Kg)
* Women in the first trimester of pregnancy
* Severely ill individuals
* Individuals on contra-indicated medication
D: Inclusion Criteria:

* Children older than 6 months and younger than 10 years in approximately 100 randomly selected households in all 140 study clusters selected in the four study areas

Exclusion Criteria:

* Children living in households within 1 km from the edge of a neighbouring cluster (the buffer zone)

Answer: B