Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Open-label Study to Evaluate the Effect of Daprodustat on Blood Pressure in Subjects With Anemia Associated With Chronic Kidney Disease on Hemodialysis Switched From a Stable Dose of an Erythropoiesis-stimulating Agent
Brief Summary: This will be an open-label, randomized, parallel-group study in hemodialysis-dependent (HD) participants with anemia associated with chronic kidney disease (CKD), designed to compare the effects of daprodustat to epoetin alfa on blood pressure (BP). Participants will be screened for eligibility within 7 and 30 days prior to erythropoesis-stimulating agent (ESA) washout. Following a 2-week ESA washout period, on Day 1 participants will be randomized 1:1 and stratified by prior ESA dose before they undergo Acute Challenge 1, a single dose challenge to compare the acute effects on BP of the highest planned once-daily maintenance dose of daprodustat (24 milligrams \[mg\]) to the highest starting dose of epoetin alfa (100 units/kilogram \[U/kg\]). This will be followed by an 8-week hemoglobin (Hgb)-maintenance period, where doses of either daprodustat or epoetin alfa will be administered and adjusted. At the end of Hgb maintenance period, on Day 57 an Acute Challenge 2 will be repeated utilizing the same treatment dose administered in Acute Challenge 1; there will be a follow-up visit within 14+/-3 days after completing treatment.


Options:
A: Arm Label: Participants receiving Epoetin alfa; Type: ACTIVE_COMPARATOR; Interventions: Drug: Epoetin alfa | Arm Label: Participants receiving Daprodustat; Type: EXPERIMENTAL; Interventions: Drug: Daprodustat | Intervention Type: DRUG; Name: Daprodustat; Assigned to Arm(s): Participants receiving Daprodustat | Intervention Type: DRUG; Name: Epoetin alfa; Assigned to Arm(s): Participants receiving Epoetin alfa
B: Arm Label: Participants receiving Daprodustat; Type: EXPERIMENTAL; Interventions: Drug: Daprodustat, Drug: Acetylcholine, Drug: Sodium nitroprusside, Drug: L-N-monomethyl arginine acetate (L-NMMA) | Arm Label: Participants receiving Darbepoetin alfa; Type: ACTIVE_COMPARATOR; Interventions: Drug: Darbepoetin alfa, Drug: Acetylcholine, Drug: Sodium nitroprusside, Drug: L-N-monomethyl arginine acetate (L-NMMA) | Intervention Type: DRUG; Name: Daprodustat; Assigned to Arm(s): Participants receiving Daprodustat | Intervention Type: DRUG; Name: Darbepoetin alfa; Assigned to Arm(s): Participants receiving Darbepoetin alfa | Intervention Type: DRUG; Name: Acetylcholine; Assigned to Arm(s): Participants receiving Daprodustat, Participants receiving Darbepoetin alfa | Intervention Type: DRUG; Name: Sodium nitroprusside; Assigned to Arm(s): Participants receiving Daprodustat, Participants receiving Darbepoetin alfa | Intervention Type: DRUG; Name: L-N-monomethyl arginine acetate (L-NMMA); Assigned to Arm(s): Participants receiving Daprodustat, Participants receiving Darbepoetin alfa
C: Arm Label: Cohort A-1 (Roxadustat 1.0 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-2 (Roxadustat 1.5 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-3 (Roxadustat 2.0 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-4 (Roxadustat 1.8 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-5 (Roxadustat 1.8 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-6 (Roxadustat 1.3 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-7 (Weight Tiered Roxadustat 70-100-150 mg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-8 (Weight Tiered Roxadustat 70-120-200 mg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-9 (Roxadustat 2.0 mg/kg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-10 (Weight Tiered Roxadustat 70-120-200 mg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohorts A (Epoetin Alfa); Type: ACTIVE_COMPARATOR; Interventions: Drug: Epoetin Alfa | Arm Label: Cohort B-1 (Roxadustat 1.5 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort B-2 (Roxadustat 2.0 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort B (Epoetin Alfa); Type: ACTIVE_COMPARATOR; Interventions: Drug: Epoetin Alfa | Arm Label: Cohort B (Placebo); Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Intervention Type: DRUG; Name: Roxadustat; Assigned to Arm(s): Cohort A-1 (Roxadustat 1.0 mg/kg TIW), Cohort A-10 (Weight Tiered Roxadustat 70-120-200 mg), Cohort A-2 (Roxadustat 1.5 mg/kg TIW), Cohort A-3 (Roxadustat 2.0 mg/kg TIW), Cohort A-4 (Roxadustat 1.8 mg/kg TIW), Cohort A-5 (Roxadustat 1.8 mg/kg TIW), Cohort A-6 (Roxadustat 1.3 mg/kg TIW), Cohort A-7 (Weight Tiered Roxadustat 70-100-150 mg), Cohort A-8 (Weight Tiered Roxadustat 70-120-200 mg), Cohort A-9 (Roxadustat 2.0 mg/kg), Cohort B-1 (Roxadustat 1.5 mg/kg TIW), Cohort B-2 (Roxadustat 2.0 mg/kg TIW) | Intervention Type: DRUG; Name: Epoetin Alfa; Assigned to Arm(s): Cohort B (Epoetin Alfa), Cohorts A (Epoetin Alfa) | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Cohort B (Placebo)
D: Arm Label: Molidustat (BAY 85-3934)(25mg); Type: EXPERIMENTAL; Interventions: Drug: Molidustat (BAY 85-3934) | Arm Label: Molidustat (BAY 85-3934)(50mg); Type: EXPERIMENTAL; Interventions: Drug: Molidustat (BAY 85-3934) | Arm Label: Molidustat (BAY 85-3934) (75mg); Type: EXPERIMENTAL; Interventions: Drug: Molidustat (BAY 85-3934) | Arm Label: Molidustat (BAY 85-3934) (150mg); Type: EXPERIMENTAL; Interventions: Drug: Molidustat (BAY 85-3934) | Arm Label: Epoetin alfa/beta; Type: ACTIVE_COMPARATOR; Interventions: Biological: Epoetin alfa/beta | Intervention Type: DRUG; Name: Molidustat (BAY 85-3934); Assigned to Arm(s): Molidustat (BAY 85-3934) (150mg), Molidustat (BAY 85-3934) (75mg), Molidustat (BAY 85-3934)(25mg), Molidustat (BAY 85-3934)(50mg) | Intervention Type: BIOLOGICAL; Name: Epoetin alfa/beta; Assigned to Arm(s): Epoetin alfa/beta

Answer: A