Please select the eligibility criteria that correspond to the clinical trial below.
Title: Treatment of Depressed Adolescents With Physical Illness
Brief Summary: The purpose of this study is a randomized trial of cognitive-behavioral intervention (CBI) for eligible adolescents who have Inflammatory Bowel Disease and subsyndromal depressive symptoms, but who did not meet diagnostic criteria for major depressive disorder at the time of randomization into the study.

Hypotheses

1. This preliminary randomized trial will demonstrate the feasibility of a large-scale research initiative.
2. Subjects will experience no adverse events, and the CBI group will demonstrate improved negative cognitions, depressive symptomatology, and functioning at the post-intervention and 6- through 12-month follow-ups.


Options:
A: Inclusion Criteria:

* aged 14-17 years. living in displaced persons camps in northern Uganda meet study-specific criteria for depression

Exclusion Criteria:

* reported age of less than 14 or older than 17 years does not live in a displaced persons camp
B: Inclusion Criteria:

* Patients between 10-25 years with diagnosed IBD
* Informed consent or assent by patients and (if necessary) parents

Exclusion Criteria:

* IBD patients with parental report of mental retardation
* IBD patients receiving psychopharmacological treatment (antidepressants or benzodiazepines) for depression or anxiety
* No mastery of the Dutch language
* IBD patients with diagnosed: Bipolar disorder, Schizophrenia/psychotic disorder, Autism spectrum disorders, Obsessive-compulsive disorder, Posttraumatic stress disorder/Acute stress disorder, or Substance use disorder
* Physician reported substance abuse (alcohol, drugs) in the past month
* Clinician reported Selective mutism
* IBD patients already participating in an (psychological of psychopharmacological) intervention study
* IBD patients who received 8 sessions of manualized cognitive behavioral therapy last year
* current psychological treatment
C: Inclusion Criteria:

* Step One

  1. Ages 11 to 17 inclusive.
  2. Capable of completing CDI
  3. English-speaking.
  4. Meeting diagnostic criteria for IBD (The date of diagnosis = date of the first diagnostic test confirming IBD)
  5. Absence of mental retardation by history
  6. Having at least one appointment at the gastroenterology clinic at CHP.
* Step Two: Assessment

  1) CDI and/or CDI-P equal to or more than 9 at Step 1
* At Intervention Phase

  1. CDI score equal to or more than 9 AND/OR CDI-P score equal to or more than 9 at T0.
  2. Absence of recent suicide attempt (within one month of study enrollment) or depression severity requiring acute psychiatric hospitalization),
  3. Age 11-17 years inclusive,
  4. Presence of at least one biological parent.

Exclusion Criteria:

1. Current major depression or dysthymia by Diagnostic and Statistical Manual (DSM)-IV criteria
2. History or current episode of bipolar disorder, eating disorder, or psychotic disorder by DSM-IV criteria.
3. Mental retardation by history
4. Antidepressant or stimulant medications within one month of assessment
5. Suicidality with plan or of severity requiring immediate psychiatric hospitalization or significant act involving intentional self-harm, e.g. cutting or overdose, resulting in medical attention.
6. Unacceptable risk for dangerousness to others as indicated by homicidal (or other violent) ideation, intent or plan or action, or use of illegal weapons.
7. Current pregnancy by history.
8. Substance abuse within one month of enrollment other than nicotine dependence.
9. Current treatment with cognitive behavioral therapy (CBT) or failure of previous CBT trial for depression judged adequate by at least 12 treatment sessions over a period of less than 1 year conducted by an appropriately trained mental health provider.
D: Inclusion Criteria:

* Youth between the ages of 12 and 18 with type 1 diabetes characterized by an HbA1c value great than 9%
* Caregivers willing to participate
* Family members reading English at 5th grade level
* Willing to be randomized.

Exclusion Criteria:

* Youth with intellectual disability
* Parent or youth who doesn't speak English

Answer: C