Please select the eligibility criteria that correspond to the clinical trial below.
Title: Day 3 vs Day 5 Embryo Transfer for Patients With Low Embryo Numbers Going Through in Vitro Fertilization (PILOT STUDY)
Brief Summary: The purpose of this small-scale pilot study (10 patients) is to test the study protocol for an RCT comparing IVF outcomes between day 3 and day 5 embryo transfer in patients with five or fewer embryos in a fresh embryo transfer in vitro fertilization (IVF) cycle. Information derived from this RCT would allow us to maximize the chances of success for these patients undergoing IVF.


Options:
A: Inclusion Criteria:

* 1st, 2nd or 3rd cycle of PGD in which embryo transfer was performed
* Indications for PGD: monogenic indications and X-linked disorders with a 25-50% risk of transmission and that are not associated with reduced ovarian response
* Normal ultrasound scan, i.e. presence of both ovaries, without evidence of abnormality within 6 months prior to randomisation.
* Regular menstrual cycles of 21-35 days, presumed to be ovulatory.

Exclusion Criteria:

* POLYCYSTIC OVARIAN SYNDROME (Rotterdam criteria \*)

  \* At least two of the following three features: (i) Oligo- and/or anovulation (ii) Clinical and/or biochemical signs of hyperandrogenism (iii) Polycystic ovaries and exclusion of other aetiologies (congenital adrenal hyperplasias, androgen-secreting tumours, Cushing's syndrome)
* Poor responders (Bologna criteria \*\*)

  \* \* At least two of the following three features: (i) Advanced maternal age (≥40 years) or any other risk factor for poor ovarian response (POR); (ii) A previous POR (≤3 oocytes with a conventional stimulation protocol); (iii) An abnormal ovarian reserve test (i.e. antral follicle count (AFC) 5-7 follicles, or anti-Mullerian hormone (AMH) 0.5-1.1 ng/ml).
* Endocrine or metabolic abnormalities (pituitary, adrenal, pancreas, liver or kidney)
* anticipated high response: AMH \>5.0 ng/ml or AFC \>20
* Endometriosis ≥ grade 3
* Age \> 40 years and 364 days
B: Inclusion Criteria:

* Women under 42 years of age
* Presence of at least 3 embryos suitable to freeze on day 2 or 3 following fertilisation based on the centre's criteria
* Written informed consent

Exclusion Criteria:

* Women using donor eggs/donor sperm
* Women undergoing preimplantation genetic diagnosis
* Women with abnormal uterine cavity shown on hysterosalpingogram or saline infusion sonogram
* Women with hydrosalpinges shown on scanning and not corrected treated
* Women with excessive ovarian response at risk of ovarian hyperstimulation where elective freeze is already planned
* Women with serum progesterone level on day of human chorionic gonadotrophin\>1.5ng/ml or 5 nmol/L
* Women whose embryos have not survived freeze-thawing in the past
* Fresh transfer is planned e.g. patients with endometriosis or adenomyosis who have received prolonged downregulation
* Only frozen transfer is planned e.g. patients receiving ovarian stimulation regimens which may have adverse impacts on the endometrium
C: Inclusion Criteria:

* First autologous IVF cycle
* Written, informed consent

Exclusion Criteria:

* Planned gestational carrier
* Planned donor egg
* Morbid obesity: BMI \>40
* History of recurrent pregnancy loss (≥2 spontaneous abortions)
* Presence of uterine factor infertility
* Treatment plan includes embryos cultured 'out of protocol'
* Planned preimplantation genetic testing
D: Inclusion Criteria:

* female patients undergoing IVF procedures
* age less than 39 years

Exclusion Criteria:

* less than 4 fertilized eggs in day 1 after IVF

Answer: C