Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomized, Multicenter, Double-blind, Placebo-controlled Efficacy and Safety Study of 8 mg PEG-uricase in Two Dose Regimens in Hyperuricemic Subjects With Symptomatic Gout
Brief Summary: These are two replicate studies to evaluate the safety and efficacy of PEG (polyethylene glycol)-uricase in controlling the uric acid level in symptomatic gout patients with high uric acid levels who are unable to take standard gout therapies, or for whom those therapies have been unsuccessful in controlling their uric acid level.


Options:
A: Arm Label: q2 wks; Type: EXPERIMENTAL; Interventions: Biological: pegloticase | Arm Label: q4 wks; Type: EXPERIMENTAL; Interventions: Biological: pegloticase | Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Intervention Type: OTHER; Name: placebo; Assigned to Arm(s): placebo | Intervention Type: BIOLOGICAL; Name: pegloticase; Assigned to Arm(s): q2 wks, q4 wks
B: Arm Label: lesinurad 400 mg + febuxostat 80 mg; Type: EXPERIMENTAL; Interventions: Drug: Lesinurad, Drug: Febuxostat | Arm Label: lesinurad 200 mg + febuxostat 80 mg; Type: EXPERIMENTAL; Interventions: Drug: Lesinurad, Drug: Febuxostat | Arm Label: placebo + febuxostat 80 mg; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Drug: Febuxostat | Intervention Type: DRUG; Name: Lesinurad; Assigned to Arm(s): lesinurad 400 mg + febuxostat 80 mg | Intervention Type: DRUG; Name: Lesinurad; Assigned to Arm(s): lesinurad 200 mg + febuxostat 80 mg | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): placebo + febuxostat 80 mg | Intervention Type: DRUG; Name: Febuxostat; Assigned to Arm(s): lesinurad 200 mg + febuxostat 80 mg, lesinurad 400 mg + febuxostat 80 mg, placebo + febuxostat 80 mg
C: Arm Label: lesinurad 200 mg + allopurinol; Type: EXPERIMENTAL; Interventions: Drug: Lesinurad, Drug: Allopurinol | Arm Label: lesinurad 400 mg + allopurinol; Type: EXPERIMENTAL; Interventions: Drug: Lesinurad, Drug: Allopurinol | Arm Label: Placebo + allopurinol; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Drug: Allopurinol | Intervention Type: DRUG; Name: Lesinurad; Assigned to Arm(s): lesinurad 200 mg + allopurinol | Intervention Type: DRUG; Name: Lesinurad; Assigned to Arm(s): lesinurad 400 mg + allopurinol | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo + allopurinol | Intervention Type: DRUG; Name: Allopurinol; Assigned to Arm(s): Placebo + allopurinol, lesinurad 200 mg + allopurinol, lesinurad 400 mg + allopurinol
D: Arm Label: lesinurad 200 mg + allopurinol; Type: EXPERIMENTAL; Interventions: Drug: Lesinurad, Drug: Allopurinol | Arm Label: lesinurad 400 mg + allopurinol; Type: EXPERIMENTAL; Interventions: Drug: Lesinurad, Drug: Allopurinol | Arm Label: Placebo + allopurinol; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Drug: Allopurinol | Intervention Type: DRUG; Name: Lesinurad; Assigned to Arm(s): lesinurad 200 mg + allopurinol | Intervention Type: DRUG; Name: Lesinurad; Assigned to Arm(s): lesinurad 400 mg + allopurinol | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo + allopurinol | Intervention Type: DRUG; Name: Allopurinol; Assigned to Arm(s): lesinurad 200 mg + allopurinol | Intervention Type: DRUG; Name: Allopurinol; Assigned to Arm(s): lesinurad 400 mg + allopurinol | Intervention Type: DRUG; Name: Allopurinol; Assigned to Arm(s): Placebo + allopurinol

Answer: A