Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized ,Open Label Study Comparing the Efficacy of Zoladex® Combined With Arimidex® for 3-2 Years After Selective Estrogen Receptor Modulators (SERMs) as an Adjuvant Therapy for 2-3 Years Versus Continuing Tamoxifen up to 5 Years for Premenopausal Early Breast Cancer Patients With Hormone Receptor Positive, Lymph Node Positive or Tumor≥ 4cm.
Brief Summary: The present study is a randomized open-label -phase III study that aims to compare the efficacy of Zoladex® combined with Aromidex® for 3-2 years after SERMs (tamoxifen and Fareston®) as an adjuvant therapy for 2-3 years with the efficacy of tamoxifen up to 5 years for premenopausal breast cancer women with hormone receptor positive, lymph node positive or tumor ≥4cm. According to St. Gallen's guideline, hormone receptor positive was defined as endocrine responsive and endocrine response uncertain categories (table 3-1), and only those with ER or PR expression undetectable were considered as HR negative. The pathological evaluation of axillary lymph node could be done by sentinel node biopsy (SNB) when axillary nodes were clinically impalpable accompanied with axillary lymph node dissection (ALND) or directly through ALND when axillary nodes appeared to be positive in clinical examination. Based on the operating standard of local medical institution, identifying the numbers of lymph nodes to do the pathological evaluation and to do the dissection of I- or II-station nodes accurately.


Options:
A: Arm Label: Switch to Zoladex + AI for 3-2 years; Type: EXPERIMENTAL; Interventions: Drug: Zoladex+AI | Arm Label: TAM; Type: EXPERIMENTAL; Interventions: Drug: TAM | Intervention Type: DRUG; Name: Zoladex+AI; Assigned to Arm(s): Switch to Zoladex + AI for 3-2 years | Intervention Type: DRUG; Name: TAM; Assigned to Arm(s): TAM
B: Arm Label: Tamoxifen; Type: ACTIVE_COMPARATOR; Interventions: Other: Laboratory Biomarker Analysis, Other: Quality-of-Life Assessment, Drug: Tamoxifen | Arm Label: T+OFS; Type: EXPERIMENTAL; Interventions: Other: Laboratory Biomarker Analysis, Procedure: Oophorectomy, Other: Quality-of-Life Assessment, Radiation: Radiation Therapy, Drug: Tamoxifen, Drug: Triptorelin | Arm Label: E+OFS; Type: EXPERIMENTAL; Interventions: Drug: Exemestane, Other: Laboratory Biomarker Analysis, Procedure: Oophorectomy, Other: Quality-of-Life Assessment, Radiation: Radiation Therapy, Drug: Triptorelin | Intervention Type: DRUG; Name: Exemestane; Assigned to Arm(s): E+OFS | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): E+OFS, T+OFS, Tamoxifen | Intervention Type: PROCEDURE; Name: Oophorectomy; Assigned to Arm(s): E+OFS, T+OFS | Intervention Type: OTHER; Name: Quality-of-Life Assessment; Assigned to Arm(s): E+OFS, T+OFS, Tamoxifen | Intervention Type: RADIATION; Name: Radiation Therapy; Assigned to Arm(s): E+OFS, T+OFS | Intervention Type: DRUG; Name: Tamoxifen; Assigned to Arm(s): T+OFS, Tamoxifen | Intervention Type: DRUG; Name: Triptorelin; Assigned to Arm(s): E+OFS, T+OFS
C: Arm Label: TAM+OFS(E) group; Type: EXPERIMENTAL; Interventions: Drug: goserelin, Drug: tamoxifen | Arm Label: TAM(D) group; Type: ACTIVE_COMPARATOR; Interventions: Drug: tamoxifen | Arm Label: Permanent postmenopausal(A) group; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: TAM(B); Type: ACTIVE_COMPARATOR; Interventions: Drug: tamoxifen | Arm Label: TAM+OFS (C); Type: EXPERIMENTAL; Interventions: Drug: goserelin, Drug: tamoxifen | Intervention Type: DRUG; Name: goserelin; Assigned to Arm(s): TAM+OFS (C), TAM+OFS(E) group | Intervention Type: DRUG; Name: tamoxifen; Assigned to Arm(s): TAM(B), TAM(D) group, TAM+OFS (C), TAM+OFS(E) group
D: Arm Label: Combination; Type: EXPERIMENTAL; Interventions: Drug: Goserelin | Arm Label: Conctrol; Type: ACTIVE_COMPARATOR; Interventions: Drug: tamoxifen | Intervention Type: DRUG; Name: tamoxifen; Assigned to Arm(s): Conctrol | Intervention Type: DRUG; Name: Goserelin; Assigned to Arm(s): Combination

Answer: A