Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: PeRioperative OXygen Fraction - Effect on Surgical Site Infection and Pulmonary Complications After Abdominal Surgery (The PROXI-trial)
Brief Summary: Aim: To investigate the effect of high intra- and postoperative oxygen concentration (80%, as opposed to normally 30%) on surgical wound infection and pulmonary complications after abdominal surgery.

Background: Surgical wound infection is a common and serious complication. Tissue oxygen tension is often low after surgery and the resistance against infection depends on this factor through bacterial killing by neutrophils. Oxygen is a substrate in this reaction, and it is hypothesized that by increasing the arterial oxygen tension, the risk of surgical wound infection is reduced. Previous studies to test this hypothesis have shown entirely different results. Hence, the clinical decision between high and normal oxygen concentration is still controversial.

Primary hypothesis of study: Use of 80% oxygen decreases the incidence of surgical wound infection after abdominal surgery.

Secondary objectives: To investigate the effect 80% oxygen on pulmonary complications (atelectasis, pneumonia, respiratory insufficiency), second operation, mortality and length of postoperative hospitalization and admission to intensive care unit after abdominal surgery.


Options:
A: Arm Label: Nasal oxygen; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nasal oxygen | Arm Label: Nasal Air; Type: PLACEBO_COMPARATOR; Interventions: Drug: Regular nasal air | Intervention Type: DRUG; Name: Nasal oxygen; Assigned to Arm(s): Nasal oxygen | Intervention Type: DRUG; Name: Regular nasal air; Assigned to Arm(s): Nasal Air
B: Arm Label: Oxygen therapy; Type: OTHER; Interventions: Other: Oxygen therapy | Arm Label: No oxygen therapy; Type: OTHER; Interventions: Other: No oxygen therapy | Intervention Type: OTHER; Name: Oxygen therapy; Assigned to Arm(s): Oxygen therapy | Intervention Type: OTHER; Name: No oxygen therapy; Assigned to Arm(s): No oxygen therapy
C: Arm Label: A; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oxygen | Arm Label: B; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oxygen | Intervention Type: DRUG; Name: Oxygen; Assigned to Arm(s): A, B
D: Arm Label: Group 1; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: Low normal PaO2, Other: Low normal MAP | Arm Label: Group 2; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: Low normal PaO2, Other: Low normal MAP | Arm Label: Group 3; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: High normal PaO2, Other: Low normal MAP | Arm Label: Group 4; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: High normal PaO2, Other: Low normal MAP | Arm Label: Group 5; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: Low normal PaO2, Other: High normal MAP | Arm Label: Group 6; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: Low normal PaO2, Other: High normal MAP | Arm Label: Group 7; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: High normal PaO2, Other: High normal MAP | Arm Label: Group 8; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: High normal PaO2, Other: High normal MAP | Intervention Type: OTHER; Name: Low normal PaCO2; Assigned to Arm(s): Group 1, Group 3, Group 5, Group 7 | Intervention Type: OTHER; Name: High normal PaCO2; Assigned to Arm(s): Group 2, Group 4, Group 6, Group 8 | Intervention Type: OTHER; Name: Low normal PaO2; Assigned to Arm(s): Group 1, Group 2, Group 5, Group 6 | Intervention Type: OTHER; Name: High normal PaO2; Assigned to Arm(s): Group 3, Group 4, Group 7, Group 8 | Intervention Type: OTHER; Name: Low normal MAP; Assigned to Arm(s): Group 1, Group 2, Group 3, Group 4 | Intervention Type: OTHER; Name: High normal MAP; Assigned to Arm(s): Group 5, Group 6, Group 7, Group 8

Answer: C