Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A PHASE 2A, RANDOMIZED, DOUBLE-BLIND, VEHICLE-CONTROLLED STUDY, TO CHARACTERIZE THE MECHANISM OF ACTION OF CRISABOROLE OINTMENT 2%, BY EVALUATION OF EFFICACY AND CHANGES IN SKIN BIOMARKERS, IN ADULT SUBJECTS WITH MILD TO MODERATE ATOPIC DERMATITIS, WITH A 4 WEEK OPEN-LABEL EXTENSION
Brief Summary: This study is being conducted to characterize the mechanism of action of crisaborole ointment 2%, by evaluation of efficacy and changes in key skin biomarkers in atopic dermatitis (AD) lesions treated with crisaborole ointment 2% over vehicle, in subjects with mild to moderate AD. Two identified AD skin lesions for each subject will be treated for the first 15 days, one with crisaborole ointment 2% and one with vehicle, in a blinded manner, and biopsies for biomarker analysis will be performed on the lesions. Following completion of the blinded treatment period, subjects will start the 28 day open label period during which all AD affected skin lesions will be treated with crisaborole ointment 2% twice daily.


Options:
A: Arm Label: Arm 1 - Standard of Care; Type: ACTIVE_COMPARATOR; Interventions: Drug: EUCRISA | Arm Label: Arm 2 - Online Treatment Response; Type: EXPERIMENTAL; Interventions: Behavioral: Online Treatment response, Drug: EUCRISA | Intervention Type: BEHAVIORAL; Name: Online Treatment response; Assigned to Arm(s): Arm 2 - Online Treatment Response | Intervention Type: DRUG; Name: EUCRISA; Assigned to Arm(s): Arm 1 - Standard of Care, Arm 2 - Online Treatment Response
B: Arm Label: Crisaborole ointment; Type: EXPERIMENTAL; Interventions: Drug: Crisaborole ointment 2% BID | Arm Label: Placebo ointment (vehicle); Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo ointment (vehicle) | Intervention Type: DRUG; Name: Crisaborole ointment 2% BID; Assigned to Arm(s): Crisaborole ointment | Intervention Type: DRUG; Name: Placebo ointment (vehicle); Assigned to Arm(s): Placebo ointment (vehicle)
C: Arm Label: Double Blind (DB): Vehicle BID; Type: PLACEBO_COMPARATOR; Interventions: Drug: Vehicle Cream BID | Arm Label: DB: Triamcinolone (TAC) 0.1% BID/Vehicle Cream BID; Type: ACTIVE_COMPARATOR; Interventions: Drug: Triamcinolone 0.1% Cream BID, Drug: Vehicle Cream BID | Arm Label: DB: Ruxolitinib 0.15% Once Daily (QD); Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 0.15% Cream QD | Arm Label: DB: Ruxolitinib 0.5% QD; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 0.5% Cream QD | Arm Label: DB: Ruxolitinib 1.5% QD; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 1.5% Cream QD | Arm Label: DB: Ruxolitinib 1.5% BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 1.5% Cream BID | Arm Label: Open-Label (OL): Vehicle BID to Ruxolitinib 1.5% BID; Type: PLACEBO_COMPARATOR; Interventions: Drug: Ruxolitinib 1.5% Cream BID | Arm Label: OL: TAC BID/Vehicle BID to Ruxolitinib 1.5% BID; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ruxolitinib 1.5% Cream BID | Arm Label: OL: Ruxolitinib 0.15% QD to Ruxolitinib 1.5% BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 1.5% Cream BID | Arm Label: OL: Ruxolitinib 0.5% QD to Ruxolitinib 1.5% BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 1.5% Cream BID | Arm Label: OL: Ruxolitinib 1.5% QD to Ruxolitinib 1.5% BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 1.5% Cream BID | Arm Label: OL: Ruxolitinib 1.5% BID to Ruxolitinib 1.5% BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 1.5% Cream BID | Intervention Type: DRUG; Name: Ruxolitinib 0.15% Cream QD; Assigned to Arm(s): DB: Ruxolitinib 0.15% Once Daily (QD) | Intervention Type: DRUG; Name: Ruxolitinib 0.5% Cream QD; Assigned to Arm(s): DB: Ruxolitinib 0.5% QD | Intervention Type: DRUG; Name: Ruxolitinib 1.5% Cream QD; Assigned to Arm(s): DB: Ruxolitinib 1.5% QD | Intervention Type: DRUG; Name: Ruxolitinib 1.5% Cream BID; Assigned to Arm(s): DB: Ruxolitinib 1.5% BID, OL: Ruxolitinib 0.15% QD to Ruxolitinib 1.5% BID, OL: Ruxolitinib 0.5% QD to Ruxolitinib 1.5% BID, OL: Ruxolitinib 1.5% BID to Ruxolitinib 1.5% BID, OL: Ruxolitinib 1.5% QD to Ruxolitinib 1.5% BID, OL: TAC BID/Vehicle BID to Ruxolitinib 1.5% BID, Open-Label (OL): Vehicle BID to Ruxolitinib 1.5% BID | Intervention Type: DRUG; Name: Triamcinolone 0.1% Cream BID; Assigned to Arm(s): DB: Triamcinolone (TAC) 0.1% BID/Vehicle Cream BID | Intervention Type: DRUG; Name: Vehicle Cream BID; Assigned to Arm(s): DB: Triamcinolone (TAC) 0.1% BID/Vehicle Cream BID, Double Blind (DB): Vehicle BID
D: Arm Label: AN2728 Topical Ointment, 2%; Type: EXPERIMENTAL; Interventions: Drug: AN2728 Topical Ointment, 2% | Arm Label: Matching vehicle control; Type: PLACEBO_COMPARATOR; Interventions: Drug: Matching vehicle control | Intervention Type: DRUG; Name: AN2728 Topical Ointment, 2%; Assigned to Arm(s): AN2728 Topical Ointment, 2% | Intervention Type: DRUG; Name: Matching vehicle control; Assigned to Arm(s): Matching vehicle control

Answer: B