Please select the eligibility criteria that correspond to the clinical trial below.
Title: Improvement of Medicine Adherence and the Following Positive Effects on Transplants in Patients After Organ Transplantation With Pilloxa's Electronic Pillbox
Brief Summary: Poor adherence to medication among patients with chronic diseases is a major problem. A patient group where the adherence to prescribed medications is extremely important are organ transplanted patients. It is well established that lack of adherence to immunosuppressive medication drastically increases the risk of rejection reactions, graft loss and deaths.

Pilloxa is a device meant to help users manage medication and support adherence to medication. This study evaluates if Pilloxa improves adherence to treatment for transplanted patient compared with conventional management. Patients who have received a transplanted kidney or liver will be studied.

Pilloxa is a system comprising of: a box with 14 separate containers to temporarily store tablets/capsules in and that can be open by 14 independent lids, a smartphone application and cloud based servers. The pillbox will at given times detect if pills are present in the different compartments and can connect, send and receive information to/from mobile application and the cloud.


Options:
A: Inclusion Criteria:

* Greater than or equal to 22 years of age
* Receive a liver transplant at Johns Hopkins Hospital

Exclusion Criteria:

* Non-English speaking liver transplant recipients
B: Inclusion Criteria:

* Patient had an organ (liver or kidney) transplanted.
* Patient who wishes to participate in the study and who is able to understand, read, write and give written informed consent in the Swedish or English language. For persons under the age of 18, the guardians must understand, read, write and give written informed consent in the Swedish or English language.
* Ongoing daily immunosuppressive medication that is expected to continue during the study period.
* Handles medication by herself or, in the case of children, that medication is handled by the guardian.
* The patients doses of immunosuppressants fits into the chambers of the product.
* The patient's medicine ordination is not expected to change more often than once weekly.
* Owns and uses a compatible smartphone, option for underage children that guardians hold a compatible smartphone.

Exclusion Criteria:

* Suffers from dementia, neurological disease or other cognitive impairment which causes problems in understanding instructions or managing medication independently.
* Physical inability to use the product as intended.
C: Inclusion Criteria:

* 1 year after kidney transplantation
* out-patient follow up in Seoul National University Hospital
* using android smartphone
* taking Prograf as a main immunosuppressant
* 15-70 years

Exclusion Criteria:

* patients who cannot use medication event monitoring system
* multiorgan transplant
* immunosuppression medication change within 4 weeks of randomization
* caregiver management of the medication regimen
* pregnancy
* patients who can not use mobile application
D: Inclusion Criteria:

- current prescription of tacrolimus less than 98% adherence to medication prescription as determined by three baseline pill counts

Exclusion Criteria:

- lack of telephone to complete pill counts lack of English proficiency to participate in adherence promotion sessions

Answer: B