Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Open Label, Active Controlled Study of AMG 162 in Subjects With Advanced Cancer Currently Being Treated With Intravenous Bisphosphonates
Brief Summary: The purpose of this trial is to determine the effectiveness of AMG 162 in reducing urinary N-telopeptide in advanced cancer subjects with bone metastases.


Options:
A: Arm Label: Arm A: Standard of Care; Type: ACTIVE_COMPARATOR; Interventions: Drug: ADT | Arm Label: Arm B: Zoledronic Acid; Type: EXPERIMENTAL; Interventions: Drug: ADT, Drug: Zoledronic Acid | Arm Label: Arm C: Docetaxel; Type: EXPERIMENTAL; Interventions: Drug: Docetaxel, Drug: Prednisolone, Drug: ADT | Arm Label: Arm D: Celecoxib; Type: EXPERIMENTAL; Interventions: Drug: Celecoxib, Drug: ADT | Arm Label: Arm E: Zoledronic Acid & Docetaxel; Type: EXPERIMENTAL; Interventions: Drug: Docetaxel, Drug: Prednisolone, Drug: ADT, Drug: Zoledronic Acid | Arm Label: Arm F: Zoledronic Acid & Celecoxib; Type: EXPERIMENTAL; Interventions: Drug: Celecoxib, Drug: ADT, Drug: Zoledronic Acid | Arm Label: Arm G: Abiraterone; Type: EXPERIMENTAL; Interventions: Drug: Prednisolone, Drug: ADT, Drug: Abiraterone | Arm Label: Arm H: M1 RT; Type: EXPERIMENTAL; Interventions: Drug: ADT, Radiation: Radiotherapy to the prostate | Arm Label: Arm J: Abiraterone * Enzalutamide; Type: EXPERIMENTAL; Interventions: Drug: Prednisolone, Drug: ADT, Drug: Abiraterone, Drug: Enzalutamide | Arm Label: Arm K: Metformin; Type: EXPERIMENTAL; Interventions: Drug: ADT, Drug: Metformin | Arm Label: Arm L: tE2; Type: EXPERIMENTAL; Interventions: Drug: Transdermal Oestradiol | Intervention Type: DRUG; Name: Celecoxib; Assigned to Arm(s): Arm D: Celecoxib, Arm F: Zoledronic Acid & Celecoxib | Intervention Type: DRUG; Name: Docetaxel; Assigned to Arm(s): Arm C: Docetaxel, Arm E: Zoledronic Acid & Docetaxel | Intervention Type: DRUG; Name: Prednisolone; Assigned to Arm(s): Arm C: Docetaxel, Arm E: Zoledronic Acid & Docetaxel, Arm G: Abiraterone, Arm J: Abiraterone * Enzalutamide | Intervention Type: DRUG; Name: ADT; Assigned to Arm(s): Arm A: Standard of Care, Arm B: Zoledronic Acid, Arm C: Docetaxel, Arm D: Celecoxib, Arm E: Zoledronic Acid & Docetaxel, Arm F: Zoledronic Acid & Celecoxib, Arm G: Abiraterone, Arm H: M1 RT, Arm J: Abiraterone * Enzalutamide, Arm K: Metformin | Intervention Type: DRUG; Name: Zoledronic Acid; Assigned to Arm(s): Arm B: Zoledronic Acid, Arm E: Zoledronic Acid & Docetaxel, Arm F: Zoledronic Acid & Celecoxib | Intervention Type: DRUG; Name: Abiraterone; Assigned to Arm(s): Arm G: Abiraterone, Arm J: Abiraterone * Enzalutamide | Intervention Type: RADIATION; Name: Radiotherapy to the prostate; Assigned to Arm(s): Arm H: M1 RT | Intervention Type: DRUG; Name: Enzalutamide; Assigned to Arm(s): Arm J: Abiraterone * Enzalutamide | Intervention Type: DRUG; Name: Metformin; Assigned to Arm(s): Arm K: Metformin | Intervention Type: DRUG; Name: Transdermal Oestradiol; Assigned to Arm(s): Arm L: tE2
B: Arm Label: AMG 162; Type: EXPERIMENTAL; Interventions: Drug: AMG 162 | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: AMG 162; Assigned to Arm(s): AMG 162 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
C: Intervention Type: DRUG; Name: clodronate disodium; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: mitoxantrone hydrochloride; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: prednisone; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: quality-of-life assessment; Assigned to Arm(s): N/A
D: Arm Label: IV Bisphosphonates q 4 weeks; Type: ACTIVE_COMPARATOR; Interventions: Drug: IV Bisphosphonate q 4 weeks | Arm Label: 180 mg AMG 162 (SC) q 12 weeks; Type: EXPERIMENTAL; Interventions: Genetic: AMG 162 180 mg (SC) q 12 weeks | Arm Label: 180 mg AMG 162 (SC) q 4 weeks; Type: EXPERIMENTAL; Interventions: Genetic: AMG 162- 180 mg q 4 weeks | Intervention Type: GENETIC; Name: AMG 162 180 mg (SC) q 12 weeks; Assigned to Arm(s): 180 mg AMG 162 (SC) q 12 weeks | Intervention Type: DRUG; Name: IV Bisphosphonate q 4 weeks; Assigned to Arm(s): IV Bisphosphonates q 4 weeks | Intervention Type: GENETIC; Name: AMG 162- 180 mg q 4 weeks; Assigned to Arm(s): 180 mg AMG 162 (SC) q 4 weeks

Answer: D