Please select the eligibility criteria that correspond to the clinical trial below.
Title: Investigation of Clinical Tolerance, Cardio-respiratory Response and Muscle Fatigue During Electrostimulation
Brief Summary: The study was designed to test the following hypothesis

Patients with high cardio-respiratory response to electrostimulation (ES), high perception of pain during ES and high ES-induced muscle fatigue, have low tolerance to ES (more difficulties to increase intensity during training).


Options:
A: Inclusion Criteria:

* Subject is diagnosed with COPD.
* 40 years-old and older
* Currently or previously smoking with a smoking history of at least 10 pack-years
* Subject understands and is able to read and write French or English

Exclusion Criteria:

* absence of neuromuscular pathology
* absence of vascular pathology
* absence of dermatosis on legs
B: Inclusion Criteria:

* COPD
* FEV1 \< 60% predicted value and FEV1/ FVC \< 70%
* 6-minute walking distance \< 400 m

Exclusion Criteria:

* Patients suffering from cardiovascular, neurological, skeletal muscle, or any other condition that could alter their capacity to perform the exercise test
* Patients taking systemic corticosteroids on a daily basis (patients having received systemic steroids for the treatment of up to two exacerbations in the preceding year and those on inhaled steroids will be allowed)
* Patients with room air PaO2 \< 60 mm Hg will be excluded.
C: Inclusion Criteria:

* All participants must be female
* Subjects must have radiographic osteoarthritis of grade 2 severity according to the Kellgren and Lawrence scale on the posterior-anterior semi-flexed view with definite osteophytes present in the medial and not lateral compartment.

Exclusion Criteria:

* Previous adverse reaction to electrical stimulation
* Inability to ambulate without the use of an assistive device (i.e cane, walker)
* Patients who have undergone a total knee arthroplasty
* Patients who have torn any knee ligament (ACL, PCL, MCL, LCL)
* Enrollees who have a demand-type cardiac pacemaker or are pregnant
* History of tibial osteotomy surgery
* Significant peripheral or central nervous system disease
* Concurrent clinically active arthritis of the hip, ankle, hindfoot or midfoot in either limb
* Concurrent bilateral radiographic evidence of tibiofemoral osteoarthritis
* Enrollees who are concurrently undergoing physical therapy for pain or OA
* Enrollees who are taking Cox-2 inhibitors or are receiving corticosteroid injections
* Subjects will be allowed to take buffered aspirin and naproxen sodium while enrolled in the study
* Enrollees who have a body mass index of greater than 40 (morbidly obese)
* Enrollees who have a CAR \> .95 (e.g. patients whose quadriceps are uninhibited)
* Enrollees who have previously undergone quadriceps NMES therapy
D: Inclusion Criteria:

* 50-85 years of age
* Scheduled for a primary unilateral TKA
* Cognitive status that allows patients to consistently comprehend and repeat back directions regarding the details of the study

Exclusion Criteria:

* History of uncontrolled hypertension or uncontrolled diabetes
* Body mass index greater than 35 kg/m\^2
* Neurological, vascular or cardiac problems that significantly limit function
* Moderate or severe osteoarthritis or other orthopedic conditions in the non-operated lower extremity that limit function

Answer: A