Please select the eligibility criteria that correspond to the clinical trial below.
Title: Effect of Daily Ingestion of Walnuts for 2 Years on Age-related Cognitive Decline and Macular Degeneration in Healthy Elderly Subjects: A Randomized, Single Blind, Dual Center, Controlled Trial
Brief Summary: This will be a systematic investigation of the role of walnuts in preventing or slowing age related cognitive decline and age related macular degeneration. 700 subjects will be recruited between 2 sites, Loma Linda University in California, USA and Hospital Clinic in Barcelona, Spain. Participants will be randomly assigned to either the walnut group or the control group for a 2 year intervention. Baseline and annual data will be collected and analyzed.


Options:
A: Inclusion Criteria:

* type 2 diabetes less than 10 years
* BMI 27-35
* women only after menopause
* diabetes treatment with diet and/or metformin
* HbA1c between 45 and 94

Exclusion Criteria:

* nicotine use
* insulin
* betablockers
* estrogens orally
* blod pressure \>160/100
* macroalbuminuria
* malignancy during the past 5 years
* alcoholism
* depression
* cardiovascular disease/stroke
* liver disease
* serious lung disease, GI disease or kidney disease
* more than 30 minutes/5 days a week of moderate exercise during the last 6 months
* resistance training during the past 6 months
* official weight loosing program during the past year
* obesity surgery
* night work
* MADRS-S (Montgomery Asberg Depression Rating Scale) \>20 points
* AUDIT \>14 points for women, \>16 points for men
* not possible to obtain venous sampling
B: Inclusion Criteria:

* Clinical diagnosis of myocardial infarction, angina, or coronary insufficiency
* Willingness to attend Coronary Clinic in Sydney Australia on a regular basis
C: Inclusion Criteria:

* Body Mass Index \> 27 kg/m2
* No chronic medication (except oral contraceptives and L-Thyroxine) or possibility to stop medication for study duration
* Able to give written informed consent

Exclusion Criteria:

* Pregnancy and nursing
* Severe cardiovascular, liver, kidney, hepatic or orthopedic disease that need treatment
* Metabolic or endocrine disease that need treatment
* Hypertension blood pressure \> 160/95 mmHg or need of \> 2 drugs
* Previous stroke or cerebral ischemia
* Significant neurologic or psychiatric disease
* Any kind of eating disorder
* Bariatric surgery in the past
* Drug or alcohol abuse
* Any cancer in the past
* Acute and chronic infections
* Metallic implants (e.g. pace makers) or conditions that do not allow MRI scans
* Body weight \> 130 kg
D: Inclusion Criteria:

* 63 to 79 years old
* healthy men and women
* able to attend clinic at a study sites

Exclusion Criteria:

* illiteracy or inability to understand the protocol
* unable to undergo neurophysiological tests
* morbid obesity (BMI greater than or equal to ≥ 40 kg/m2)
* uncontrolled diabetes (HbA1c\>85)
* uncontrolled hypertension
* prior cerebrovascular accident
* any relevant psychiatric illness, including major depression
* advanced cognitive deterioration, dementia
* other neurodegenerative diseases (i.e. Parkinson's disease)
* any chronic illness expected to shorten survival (heart, liver, cancer, etc)
* bereavement in the first year of loss
* bad dentures unless fixable dental prostheses are used
* allergy to walnuts
* customary us of fish oil or flaxseed oil supplements
* eye related exclusion criteria

Answer: D