Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Four-week Phase IIa, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multi-center Study to Evaluate the Safety, Efficacy and Pharmacokinetics of GSK1278863 in Subjects With Anemia Associated With Chronic Kidney Disease Who Are Not Taking Recombinant Human Erythropoietin and Are Not Undergoing Dialysis
Brief Summary: This is a four-week Phase IIa, randomized, double-blind, placebo-controlled, parallel-group, multi-center study to evaluate the safety, efficacy and pharmacokinetics of GSK1278863 in approximately 68 subjects with anemia associated with chronic kidney disease who are not taking rhEPO and are not undergoing dialysis. The range of Hgb values for study eligibility is 8.5-11.0 g/dL. Eligible subjects will be randomized in equal proportions to receive once daily (QD) placebo or GSK1278863 0.5 mg, 2 mg or 5 mg in a double-blind fashion.


Options:
A: Arm Label: Cohort A-1 (Roxadustat 1.0 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-2 (Roxadustat 1.5 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-3 (Roxadustat 2.0 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-4 (Roxadustat 1.8 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-5 (Roxadustat 1.8 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-6 (Roxadustat 1.3 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-7 (Weight Tiered Roxadustat 70-100-150 mg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-8 (Weight Tiered Roxadustat 70-120-200 mg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-9 (Roxadustat 2.0 mg/kg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-10 (Weight Tiered Roxadustat 70-120-200 mg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohorts A (Epoetin Alfa); Type: ACTIVE_COMPARATOR; Interventions: Drug: Epoetin Alfa | Arm Label: Cohort B-1 (Roxadustat 1.5 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort B-2 (Roxadustat 2.0 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort B (Epoetin Alfa); Type: ACTIVE_COMPARATOR; Interventions: Drug: Epoetin Alfa | Arm Label: Cohort B (Placebo); Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Intervention Type: DRUG; Name: Roxadustat; Assigned to Arm(s): Cohort A-1 (Roxadustat 1.0 mg/kg TIW), Cohort A-10 (Weight Tiered Roxadustat 70-120-200 mg), Cohort A-2 (Roxadustat 1.5 mg/kg TIW), Cohort A-3 (Roxadustat 2.0 mg/kg TIW), Cohort A-4 (Roxadustat 1.8 mg/kg TIW), Cohort A-5 (Roxadustat 1.8 mg/kg TIW), Cohort A-6 (Roxadustat 1.3 mg/kg TIW), Cohort A-7 (Weight Tiered Roxadustat 70-100-150 mg), Cohort A-8 (Weight Tiered Roxadustat 70-120-200 mg), Cohort A-9 (Roxadustat 2.0 mg/kg), Cohort B-1 (Roxadustat 1.5 mg/kg TIW), Cohort B-2 (Roxadustat 2.0 mg/kg TIW) | Intervention Type: DRUG; Name: Epoetin Alfa; Assigned to Arm(s): Cohort B (Epoetin Alfa), Cohorts A (Epoetin Alfa) | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Cohort B (Placebo)
B: Arm Label: 0.5mg GSK1278863; Type: EXPERIMENTAL; Interventions: Drug: GSK1278863 | Arm Label: 2mg GSK1278863; Type: EXPERIMENTAL; Interventions: Drug: GSK1278863 | Arm Label: 5mg GSK1278863; Type: EXPERIMENTAL; Interventions: Drug: GSK1278863 | Arm Label: Placebo; Type: EXPERIMENTAL; Interventions: Other: Placebo | Intervention Type: DRUG; Name: GSK1278863; Assigned to Arm(s): 0.5mg GSK1278863, 2mg GSK1278863, 5mg GSK1278863 | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: Molidustat group; Type: EXPERIMENTAL; Interventions: Drug: Molidustat (BAY85-3934), Drug: Placebo of Darbepoetin alfa | Arm Label: Darbepoetin alfa group; Type: ACTIVE_COMPARATOR; Interventions: Drug: Darbepoetin alfa, Drug: Placebo of Molidustat (BAY85-3934) | Intervention Type: DRUG; Name: Molidustat (BAY85-3934); Assigned to Arm(s): Molidustat group | Intervention Type: DRUG; Name: Darbepoetin alfa; Assigned to Arm(s): Darbepoetin alfa group | Intervention Type: DRUG; Name: Placebo of Molidustat (BAY85-3934); Assigned to Arm(s): Darbepoetin alfa group | Intervention Type: DRUG; Name: Placebo of Darbepoetin alfa; Assigned to Arm(s): Molidustat group
D: Arm Label: Vadadustat once daily (QD); Type: EXPERIMENTAL; Interventions: Drug: Vadadustat | Arm Label: Vadadustat three times weekly (TIW); Type: EXPERIMENTAL; Interventions: Drug: Vadadustat | Arm Label: Darbepoetin alfa; Type: ACTIVE_COMPARATOR; Interventions: Drug: Darbepoetin alfa | Intervention Type: DRUG; Name: Vadadustat; Assigned to Arm(s): Vadadustat once daily (QD), Vadadustat three times weekly (TIW) | Intervention Type: DRUG; Name: Darbepoetin alfa; Assigned to Arm(s): Darbepoetin alfa

Answer: B