Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Phase III Multicentric Trial Comparing Accelerated Partial Breast Irradiation (APBI) Versus Standard or Hypofractionated Whole Breast Irradiation in Low Risk of Local Recurrence of Breast Cancer
Brief Summary: The standard treatment for localized breast cancer is based on conservative surgery (when possible) followed by radiation therapy (RT) delivered to the whole breast. The recommended total RT dose is 45 to 50 Gy delivered in 4.5 to 5 weeks followed by a 10 to 16 Gy boost to the tumor bed for 1 to 1.5 weeks. The rationale for the development of APBI was based on the difficulty for many patients to reach RT centers to receive standard whole breast irradiation (WBI) after conservative surgery. APBI offers decreased overall treatment time and several theoretical advantages over WBI, including a decrease in dose delivered to uninvolved portions of the breast and adjacent organs. If equivalence between the two treatments can be shown, then APBI will be considered as a historic evolution in breast cancer management.

In this phase III trial, designed in postmenopausal women \>50 years of age, the objective is to compare the effectiveness and safety of APBI compared with whole breast irradiation. This study is also designed to ensure high quality criteria for surgery, pathology and RT techniques in the 3 arms and will allow to provide data on economics and costs.


Options:
A: Arm Label: Standard or Hypofractionated radiotherapy; Type: ACTIVE_COMPARATOR; Interventions: Radiation: Whole Breast Irradiation + Boost or Hypofractionated irradiation | Arm Label: Accelerated Partial Breast Irradiation (APBI); Type: EXPERIMENTAL; Interventions: Radiation: Accelerated partial breast irradiation | Intervention Type: RADIATION; Name: Whole Breast Irradiation + Boost or Hypofractionated irradiation; Assigned to Arm(s): Standard or Hypofractionated radiotherapy | Intervention Type: RADIATION; Name: Accelerated partial breast irradiation; Assigned to Arm(s): Accelerated Partial Breast Irradiation (APBI)
B: Arm Label: ELIOT; Type: EXPERIMENTAL; Interventions: Radiation: intraoperative radiotherapy | Arm Label: EXTERNAL RT; Type: ACTIVE_COMPARATOR; Interventions: Radiation: external fractionated radiotherapy | Intervention Type: RADIATION; Name: external fractionated radiotherapy; Assigned to Arm(s): EXTERNAL RT | Intervention Type: RADIATION; Name: intraoperative radiotherapy; Assigned to Arm(s): ELIOT
C: Arm Label: APBI; Type: EXPERIMENTAL; Interventions: Radiation: Accelerated partial breast irradiation | Arm Label: EBRT; Type: ACTIVE_COMPARATOR; Interventions: Radiation: External beam whole breast irradiation | Intervention Type: RADIATION; Name: Accelerated partial breast irradiation; Assigned to Arm(s): APBI | Intervention Type: RADIATION; Name: External beam whole breast irradiation; Assigned to Arm(s): EBRT
D: Arm Label: Intra-operative radiotherapy; Type: EXPERIMENTAL; Interventions: Device: Intrabeam | Arm Label: Post-operative radiotherapy; Type: ACTIVE_COMPARATOR; Interventions: Radiation: Post-operative radiotherapy | Intervention Type: DEVICE; Name: Intrabeam; Assigned to Arm(s): Intra-operative radiotherapy | Intervention Type: RADIATION; Name: Post-operative radiotherapy; Assigned to Arm(s): Post-operative radiotherapy

Answer: A