Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomised, Open-label, Phase III Study of BIBW 2992 Versus Chemotherapy as First-line Treatment for Patients With Stage IIIB or IV Adenocarcinoma of the Lung Harbouring an EGFR Activating Mutation
Brief Summary: This randomised, open label phase III trial will be performed in patients with adenocarcinoma of the lung with tumours harbouring an Epidermal Growth Factor Receptor activating mutation. The objectives of the trial are to compare the efficacy of single agent BIBW 2992, Arm A, with Pemetrexed/Cisplatin chemotherapy, Arm B, as first line treatment for this group of patients.


Options:
A: Intervention Type: DRUG; Name: Abacavir; Assigned to Arm(s): N/A
B: Arm Label: non taxane based chemotherapy; Type: ACTIVE_COMPARATOR; Interventions: Biological: filgrastim, Drug: cyclophosphamide, Drug: epirubicin hydrochloride, Drug: fluorouracil, Genetic: microarray analysis, Other: immunohistochemistry staining method, Other: laboratory biomarker analysis, Procedure: biopsy, Procedure: conventional surgery, Procedure: neoadjuvant therapy, Radiation: radiation therapy | Arm Label: taxane based chemotherapy; Type: EXPERIMENTAL; Interventions: Drug: docetaxel, Drug: epirubicin hydrochloride, Genetic: microarray analysis, Other: immunohistochemistry staining method, Other: laboratory biomarker analysis, Procedure: biopsy, Procedure: conventional surgery, Procedure: neoadjuvant therapy, Radiation: radiation therapy | Intervention Type: BIOLOGICAL; Name: filgrastim; Assigned to Arm(s): non taxane based chemotherapy | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): non taxane based chemotherapy | Intervention Type: DRUG; Name: docetaxel; Assigned to Arm(s): taxane based chemotherapy | Intervention Type: DRUG; Name: epirubicin hydrochloride; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy | Intervention Type: DRUG; Name: fluorouracil; Assigned to Arm(s): non taxane based chemotherapy | Intervention Type: GENETIC; Name: microarray analysis; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy | Intervention Type: OTHER; Name: immunohistochemistry staining method; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy | Intervention Type: OTHER; Name: laboratory biomarker analysis; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy | Intervention Type: PROCEDURE; Name: biopsy; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy | Intervention Type: PROCEDURE; Name: neoadjuvant therapy; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy
C: Arm Label: BIBW 2992; Type: EXPERIMENTAL; Interventions: Drug: BIBW 2992 | Arm Label: Cisplatin/Pemetrexed; Type: ACTIVE_COMPARATOR; Interventions: Drug: Pemetrexed, Drug: Cisplatin | Intervention Type: DRUG; Name: Pemetrexed; Assigned to Arm(s): Cisplatin/Pemetrexed | Intervention Type: DRUG; Name: BIBW 2992; Assigned to Arm(s): BIBW 2992 | Intervention Type: DRUG; Name: Cisplatin; Assigned to Arm(s): Cisplatin/Pemetrexed
D: Arm Label: PGx-treatment; Type: EXPERIMENTAL; Interventions: Drug: Isoniazid | Arm Label: STD-treatment; Type: ACTIVE_COMPARATOR; Interventions: Drug: isoniazed | Intervention Type: DRUG; Name: Isoniazid; Assigned to Arm(s): PGx-treatment | Intervention Type: DRUG; Name: isoniazed; Assigned to Arm(s): STD-treatment

Answer: C