Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase III Multicenter, Randomized, Double-blind, Double-dummy, Active-controlled, Parallel Group Study of the Efficacy and Safety of Oral Netupitant Administered in Combination With Palonosetron and Dexamethasone Compared to Oral Palonosetron and Dexamethasone for the Prevention of Nausea and Vomiting in Cancer Patients Receiving Moderately Emetogenic Chemotherapy
Brief Summary: NETU-08-18 is a two-arm clinical study assessing efficacy and safety of a single oral dose of netupitant and palonosetron, two antiemetic drugs, versus oral palonosetron, both given with oral dexamethasone. The objective of the study is to demonstrate that netupitant and palonosetron are more effective than palonosetron alone, to prevent nausea and vomiting induced by moderately emetogenic cancer chemotherapy after administration of repeated cycles of chemotherapy.


Options:
A: Arm Label: Netupitant and Palonosetron+dexamethasone-cycle 1; Type: EXPERIMENTAL; Interventions: Drug: Netupitant and Palonosetron, Drug: Dexamethasone | Arm Label: Palonosetron+dexamethasone-cycle 1; Type: ACTIVE_COMPARATOR; Interventions: Drug: Palonosetron, Drug: Dexamethasone | Arm Label: Netupitant and Palonosetron+dexamethasone-multicycle extension; Type: EXPERIMENTAL; Interventions: Drug: Netupitant and Palonosetron, Drug: Dexamethasone | Arm Label: Palonosetron+dexamethasone-multicycle extension; Type: ACTIVE_COMPARATOR; Interventions: Drug: Palonosetron, Drug: Dexamethasone | Intervention Type: DRUG; Name: Netupitant and Palonosetron; Assigned to Arm(s): Netupitant and Palonosetron+dexamethasone-cycle 1, Netupitant and Palonosetron+dexamethasone-multicycle extension | Intervention Type: DRUG; Name: Palonosetron; Assigned to Arm(s): Palonosetron+dexamethasone-cycle 1, Palonosetron+dexamethasone-multicycle extension | Intervention Type: DRUG; Name: Dexamethasone; Assigned to Arm(s): Netupitant and Palonosetron+dexamethasone-cycle 1, Netupitant and Palonosetron+dexamethasone-multicycle extension, Palonosetron+dexamethasone-cycle 1, Palonosetron+dexamethasone-multicycle extension
B: Arm Label: Control; Type: PLACEBO_COMPARATOR; Interventions: Drug: Dexamethasone, Drug: Placebo, Drug: Ondansetron | Arm Label: Single Dose IV; Type: EXPERIMENTAL; Interventions: Drug: Casopitant, Drug: Dexamethasone, Drug: Ondansetron | Intervention Type: DRUG; Name: Casopitant; Assigned to Arm(s): Single Dose IV | Intervention Type: DRUG; Name: Dexamethasone; Assigned to Arm(s): Control, Single Dose IV | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Control | Intervention Type: DRUG; Name: Ondansetron; Assigned to Arm(s): Control, Single Dose IV
C: Arm Label: Arm A: Aprepitant, Then Placebo; Type: EXPERIMENTAL; Interventions: Drug: Aprepitant, Drug: Placebo | Arm Label: Arm B: Placebo, Then Aprepitant; Type: EXPERIMENTAL; Interventions: Drug: Aprepitant, Drug: Placebo | Intervention Type: DRUG; Name: Aprepitant; Assigned to Arm(s): Arm A: Aprepitant, Then Placebo, Arm B: Placebo, Then Aprepitant | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Arm A: Aprepitant, Then Placebo, Arm B: Placebo, Then Aprepitant
D: Arm Label: ramosetron, aprepitant, dexamethasone; Type: EXPERIMENTAL; Interventions: Drug: ramosetron | Arm Label: ondansetron, aprepitant, dexamethasone; Type: ACTIVE_COMPARATOR; Interventions: Drug: ondansetron | Intervention Type: DRUG; Name: ramosetron; Assigned to Arm(s): ramosetron, aprepitant, dexamethasone | Intervention Type: DRUG; Name: ondansetron; Assigned to Arm(s): ondansetron, aprepitant, dexamethasone

Answer: A