Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: N/A
Brief Summary: A recent meta-analysis that included over 29.000 individuals found that the odds ratio (OR) of individuals with high brain reserve compared to low was 0.54 (p \< 0.0001), a risk decrease of 46%. Among the factors that influence cognitive reserve, mentally stimulating activities was the most robust factor after controlling for education, age, occupation and other potential confounds. The brain reserve effect was sustained over a median longitudinal follow-up of 7 years. It would be interesting to detect whether a complex cognitive training could show similar effects on the cognitive abilities of patients with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI) as it has been reported in previous studies based on mentally stimulating activities analysis.

The hypothesis is that a complex cognitive training alters the neural networks in both subject groups and this alteration is associated with improvement or stabilization of cognitive and non-cognitive function.

The investigator will perform a complex cognitive training program. Twenty patients with mild AD and twenty four patients with MCI will be recruited in this study. The patients will be randomised in control- and treatment groups.Additionally indirect effects on non-cognitive functions will be evaluated in caregivers of the patients.

The investigators expect that the cognitive and non-cognitive abilities will be changed during the cognitive training. The investigators also expect differences between treatment and control groups.


Options:
A: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Behavioral: complex cognitive training | Arm Label: 2; Type: PLACEBO_COMPARATOR; Interventions: Behavioral: complex cognitive training | Intervention Type: BEHAVIORAL; Name: complex cognitive training; Assigned to Arm(s): 1, 2
B: Arm Label: Exercise Intervention Group; Type: EXPERIMENTAL; Interventions: Behavioral: Exercise Intervention | Arm Label: Exercise Control group; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Exercise Control | Intervention Type: BEHAVIORAL; Name: Exercise Intervention; Assigned to Arm(s): Exercise Intervention Group | Intervention Type: BEHAVIORAL; Name: Exercise Control; Assigned to Arm(s): Exercise Control group
C: Arm Label: Clinic-based SOPT basic training; Type: EXPERIMENTAL; Interventions: Behavioral: SOPT basic training | Arm Label: Home-based SOPT basic training; Type: EXPERIMENTAL; Interventions: Behavioral: SOPT basic training | Arm Label: Crossword Puzzles Training; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Crossword Puzzles | Arm Label: SOPT basic and SOPT booster-training; Type: EXPERIMENTAL; Interventions: Behavioral: SOPT basic training, Behavioral: SOPT booster training | Intervention Type: BEHAVIORAL; Name: SOPT basic training; Assigned to Arm(s): Clinic-based SOPT basic training, Home-based SOPT basic training, SOPT basic and SOPT booster-training | Intervention Type: BEHAVIORAL; Name: Crossword Puzzles; Assigned to Arm(s): Crossword Puzzles Training | Intervention Type: BEHAVIORAL; Name: SOPT booster training; Assigned to Arm(s): SOPT basic and SOPT booster-training
D: Arm Label: Nutritional Intervention; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Nutritional Intervention | Arm Label: Physical Exercise; Type: EXPERIMENTAL; Interventions: Other: Physical Exercise | Arm Label: Cognitive Training; Type: EXPERIMENTAL; Interventions: Other: Cognitive Training | Arm Label: Combined; Type: EXPERIMENTAL; Interventions: Other: Combined | Arm Label: Control Group; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: Nutritional Intervention; Assigned to Arm(s): Nutritional Intervention | Intervention Type: OTHER; Name: Physical Exercise; Assigned to Arm(s): Physical Exercise | Intervention Type: OTHER; Name: Cognitive Training; Assigned to Arm(s): Cognitive Training | Intervention Type: OTHER; Name: Combined; Assigned to Arm(s): Combined | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Control Group

Answer: A