Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase 1, Multi-center, Single-masked, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Ophthalmologic Safety and Pharmacodynamics of 300mg Single Doses of Tafenoquine (SB 252263) in Adult Healthy Volunteers
Brief Summary: The study aims to provide evidence of retinal safety to support the use of tafenoquine as a potential single dose radical cure treatment for patients with Plasmodium vivax (P. vivax) malaria (i.e., co-administration of a schizonticidal drug with TQ). The study will be conducted as a single masked, randomized, placebo-controlled, parallel group design. It will assess retinal changes from baseline using spectral domain optical coherence tomography (OCT) and fundus auto fluorescence (FAF) at Month 3 (90 days) post-dose in adult healthy volunteers (participants). A placebo control group will be used to compare the results in the TQ group. Interim analysis will be conducted after completing 100 out of 300 participants in TQ group and 50 out of 150 participants in matched placebo.


Options:
A: Arm Label: Tafenoquine 50mg; Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Tafenoquine 50mg | Arm Label: Tafenoquine 100mg; Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Tafenoquine 100mg | Arm Label: Tafenoquine 300mg; Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Tafenoquine 300mg | Arm Label: Tafenoquine 600mg; Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Tafenoquine 600mg | Arm Label: Primaquine 15mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Primaquine 15mg | Arm Label: Chloroquine only; Type: PLACEBO_COMPARATOR; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg | Arm Label: Tafenoquine 300mg (Part 2); Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg (Part 2 ), Drug: Chloroquine 300mg (Part 2 ), Drug: Tafenoquine 300mg (Part 2) | Arm Label: Primaquine 15mg (Part 2); Type: ACTIVE_COMPARATOR; Interventions: Drug: Chloroquine 600mg (Part 2 ), Drug: Chloroquine 300mg (Part 2 ), Drug: Primaquine 15mg (Part2 ) | Arm Label: Chloroquine only (Part 2); Type: PLACEBO_COMPARATOR; Interventions: Drug: Chloroquine 600mg (Part 2 ), Drug: Chloroquine 300mg (Part 2 ) | Intervention Type: DRUG; Name: Chloroquine 600mg; Assigned to Arm(s): Chloroquine only, Primaquine 15mg, Tafenoquine 100mg, Tafenoquine 300mg, Tafenoquine 50mg, Tafenoquine 600mg | Intervention Type: DRUG; Name: Chloroquine 300mg; Assigned to Arm(s): Chloroquine only, Primaquine 15mg, Tafenoquine 100mg, Tafenoquine 300mg, Tafenoquine 50mg, Tafenoquine 600mg | Intervention Type: DRUG; Name: Tafenoquine 50mg; Assigned to Arm(s): Tafenoquine 50mg | Intervention Type: DRUG; Name: Tafenoquine 100mg; Assigned to Arm(s): Tafenoquine 100mg | Intervention Type: DRUG; Name: Tafenoquine 300mg; Assigned to Arm(s): Tafenoquine 300mg | Intervention Type: DRUG; Name: Tafenoquine 600mg; Assigned to Arm(s): Tafenoquine 600mg | Intervention Type: DRUG; Name: Primaquine 15mg; Assigned to Arm(s): Primaquine 15mg | Intervention Type: DRUG; Name: Chloroquine 600mg (Part 2 ); Assigned to Arm(s): Chloroquine only (Part 2), Primaquine 15mg (Part 2), Tafenoquine 300mg (Part 2) | Intervention Type: DRUG; Name: Chloroquine 300mg (Part 2 ); Assigned to Arm(s): Chloroquine only (Part 2), Primaquine 15mg (Part 2), Tafenoquine 300mg (Part 2) | Intervention Type: DRUG; Name: Tafenoquine 300mg (Part 2); Assigned to Arm(s): Tafenoquine 300mg (Part 2) | Intervention Type: DRUG; Name: Primaquine 15mg (Part2 ); Assigned to Arm(s): Primaquine 15mg (Part 2)
B: Arm Label: Tafenoquine+ Chloroquine; Type: EXPERIMENTAL; Interventions: Drug: Tafenoquine, Drug: Chloroquine, Drug: Primaquine Placebo | Arm Label: Primaquine+ Chloroquine; Type: EXPERIMENTAL; Interventions: Drug: Tafenoquine Placebo, Drug: Chloroquine, Drug: Primaquine | Intervention Type: DRUG; Name: Tafenoquine; Assigned to Arm(s): Tafenoquine+ Chloroquine | Intervention Type: DRUG; Name: Tafenoquine Placebo; Assigned to Arm(s): Primaquine+ Chloroquine | Intervention Type: DRUG; Name: Chloroquine; Assigned to Arm(s): Primaquine+ Chloroquine, Tafenoquine+ Chloroquine | Intervention Type: DRUG; Name: Primaquine; Assigned to Arm(s): Primaquine+ Chloroquine | Intervention Type: DRUG; Name: Primaquine Placebo; Assigned to Arm(s): Tafenoquine+ Chloroquine
C: Arm Label: Tafenoquine 300 milligram (mg) single dose; Type: EXPERIMENTAL; Interventions: Drug: Tafenoquine 150 mg | Arm Label: Matched Placebo 300mg single dose; Type: PLACEBO_COMPARATOR; Interventions: Drug: Matched placebo 150mg | Intervention Type: DRUG; Name: Tafenoquine 150 mg; Assigned to Arm(s): Tafenoquine 300 milligram (mg) single dose | Intervention Type: DRUG; Name: Matched placebo 150mg; Assigned to Arm(s): Matched Placebo 300mg single dose
D: Arm Label: Cohort 1 Tafenoquine; Type: EXPERIMENTAL; Interventions: Drug: Tafenoquine | Arm Label: Cohort 1-Chloroquine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Chloroquine + Primaquine | Arm Label: Cohort 2 Tafenoquine; Type: EXPERIMENTAL; Interventions: Drug: tafenoquine | Arm Label: Cohort 2 Chloroquine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Chloroquine + Primaquine | Intervention Type: DRUG; Name: Tafenoquine; Assigned to Arm(s): Cohort 1 Tafenoquine | Intervention Type: DRUG; Name: Chloroquine + Primaquine; Assigned to Arm(s): Cohort 1-Chloroquine | Intervention Type: DRUG; Name: tafenoquine; Assigned to Arm(s): Cohort 2 Tafenoquine | Intervention Type: DRUG; Name: Chloroquine + Primaquine; Assigned to Arm(s): Cohort 2 Chloroquine

Answer: C