Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase I/II Prospective, Randomized, Multicenter, Double-Masked, Vehicle-Controlled Clinical Trial to Evaluate the Safety and Efficacy of Corneal Collagen Cross-Linking of Keratoprosthesis Carrier Tissue in High-Risk Keratoprosthesis Implantation
Brief Summary: This is a phase I/II prospective, randomized, multi-center, double-masked, vehicle-controlled clinical trial evaluating the safety and efficacy of corneal collagen cross-linking the keratoprosthesis carrier tissue in subjects who are candidates for high-risk keratoprosthesis implantation but because of a history of corneal melts or autoimmune diseases are not candidate for a traditional corneal transplant.


Options:
A: Arm Label: Accelerated Corneal Cross-linking; Type: EXPERIMENTAL; Interventions: Procedure: Accelerated Corneal Cross-linking | Arm Label: Sham Accelerated Corneal Cross-linking; Type: SHAM_COMPARATOR; Interventions: Procedure: Accelerated Corneal Cross-linking | Intervention Type: PROCEDURE; Name: Accelerated Corneal Cross-linking; Assigned to Arm(s): Accelerated Corneal Cross-linking, Sham Accelerated Corneal Cross-linking
B: Arm Label: Bacterial ulcer cross-linking; Type: EXPERIMENTAL; Interventions: Procedure: Corneal Cross-linking | Arm Label: Bacterial ulcer control; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Corneal Cross-linking | Arm Label: Fungal ulcer cross-linking plus natamycin; Type: EXPERIMENTAL; Interventions: Procedure: Corneal Cross-linking, Drug: Anti Fungal Drug | Arm Label: Fungal ulcer control with natamycin; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Corneal Cross-linking, Drug: Anti Fungal Drug | Arm Label: Fungal ulcer cross-linking plus amphotericin; Type: EXPERIMENTAL; Interventions: Procedure: Corneal Cross-linking, Drug: Anti Fungal Drug | Arm Label: Fungal ulcer control with amphotericin; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Corneal Cross-linking, Drug: Anti Fungal Drug | Intervention Type: PROCEDURE; Name: Corneal Cross-linking; Assigned to Arm(s): Bacterial ulcer control, Bacterial ulcer cross-linking, Fungal ulcer control with amphotericin, Fungal ulcer control with natamycin, Fungal ulcer cross-linking plus amphotericin, Fungal ulcer cross-linking plus natamycin | Intervention Type: DRUG; Name: Anti Fungal Drug; Assigned to Arm(s): Fungal ulcer control with amphotericin, Fungal ulcer control with natamycin, Fungal ulcer cross-linking plus amphotericin, Fungal ulcer cross-linking plus natamycin
C: Arm Label: 30 minute light duration; Type: ACTIVE_COMPARATOR; Interventions: Drug: riboflavin, Device: UVX Light | Arm Label: 45 minute light duration; Type: ACTIVE_COMPARATOR; Interventions: Device: UVX Light | Intervention Type: DRUG; Name: riboflavin; Assigned to Arm(s): 30 minute light duration | Intervention Type: DEVICE; Name: UVX Light; Assigned to Arm(s): 30 minute light duration, 45 minute light duration
D: Arm Label: Active Treatment Arm; Type: EXPERIMENTAL; Interventions: Drug: Riboflavin, Drug: Dextran, Device: UVA Light Source | Arm Label: Control Treatment Arm; Type: ACTIVE_COMPARATOR; Interventions: Drug: Riboflavin, Drug: Dextran | Intervention Type: DRUG; Name: Riboflavin; Assigned to Arm(s): Active Treatment Arm, Control Treatment Arm | Intervention Type: DRUG; Name: Dextran; Assigned to Arm(s): Active Treatment Arm, Control Treatment Arm | Intervention Type: DEVICE; Name: UVA Light Source; Assigned to Arm(s): Active Treatment Arm

Answer: D