Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: PAracetamol and NSAID in Combination: A Randomised, Blinded, Parallel, 4-group Clinical Trial
Brief Summary: Trial name: PAracetamol and NSAID in combination: A randomised, blinded, parallel, 4-group clinical trial

Trial acronym: PANSAID

Background: Effective postoperative pain management is essential for the well-being and rehabilitation of the surgical patient. No "gold standard" exists after total hip arthroplasty (THA) and combinations of different non-opioid medications are used with virtually no evidence for additional analgesic efficacy compared to monotherapy.

Objectives: The objective of this trial is to investigate the analgesic effects and safety of paracetamol and ibuprofen and their combination in different dosages after THA.

Intervention: Patients are randomised to 4 groups: A) paracetamol 1 g x 4 and ibuprofen 400 mg x 4; B) paracetamol 1 g x 4 and placebo (ibuprofen); C) placebo (paracetamol) and ibuprofen 400 mg x 4; and D) paracetamol 0,5 g x 4 and ibuprofen 200 mg.

Design: Placebo controlled, parallel 4-group, multicentre trial with adequate centralised computer-generated allocation sequence and allocation concealment with varying block size and stratification by site. Blinding of assessor, investigator, caregivers, patients, and statisticians.

Sample size: 556 eligible patients are needed to detect a difference of 10 mg morphine the first postoperative day with a standard deviation of 20 mg and a type 1 error rate of 0,004 (two-sided) and a type 2 error rate of 0,10.


Options:
A: Arm Label: Preemptive; Type: ACTIVE_COMPARATOR; Interventions: Drug: Etoricoxibe | Arm Label: Postoperative; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Etoricoxibe; Assigned to Arm(s): Preemptive | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Postoperative
B: Arm Label: Dexketoprofen trometamol; Type: EXPERIMENTAL; Interventions: Drug: Dexketoprofen trometamol | Arm Label: Preoperative control; Type: PLACEBO_COMPARATOR; Interventions: Drug: Preoperative control | Intervention Type: DRUG; Name: Dexketoprofen trometamol; Assigned to Arm(s): Dexketoprofen trometamol | Intervention Type: DRUG; Name: Preoperative control; Assigned to Arm(s): Preoperative control
C: Arm Label: Group ETORICOXIB PREOP; Type: EXPERIMENTAL; Interventions: Drug: Etoricoxib, Drug: Placebo | Arm Label: Group ETORICOXIB POSTOP; Type: EXPERIMENTAL; Interventions: Drug: Etoricoxib, Drug: Placebo | Arm Label: Group PLACEBO; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Etoricoxib; Assigned to Arm(s): Group ETORICOXIB POSTOP, Group ETORICOXIB PREOP | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Group ETORICOXIB POSTOP, Group ETORICOXIB PREOP, Group PLACEBO
D: Arm Label: Treatment A:; Type: ACTIVE_COMPARATOR; Interventions: Drug: Paracetamol (1g x 4), Drug: Ibuprofen (400 mg x 4) | Arm Label: Treatment B:; Type: ACTIVE_COMPARATOR; Interventions: Drug: Paracetamol (1g x 4), Drug: Placebo (x4) | Arm Label: Treatment C:; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ibuprofen (400 mg x 4), Drug: Placebo (x4) | Arm Label: Treatment D:; Type: ACTIVE_COMPARATOR; Interventions: Drug: Paracetamol (0,5 g x 4), Drug: Ibuprofen (200 mg x 4) | Intervention Type: DRUG; Name: Paracetamol (1g x 4); Assigned to Arm(s): Treatment A:, Treatment B: | Intervention Type: DRUG; Name: Ibuprofen (400 mg x 4); Assigned to Arm(s): Treatment A:, Treatment C: | Intervention Type: DRUG; Name: Paracetamol (0,5 g x 4); Assigned to Arm(s): Treatment D: | Intervention Type: DRUG; Name: Ibuprofen (200 mg x 4); Assigned to Arm(s): Treatment D: | Intervention Type: DRUG; Name: Placebo (x4); Assigned to Arm(s): Treatment B:, Treatment C:

Answer: D