Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomised, Double Blind, Parallel Group Study to Assess the Efficacy and Safety of 12 Weeks of Once Daily, Orally Inhaled, Co-administration of Olodaterol 5µg (Delivered by the Respimat® Inhaler) and Tiotropium 18µg (Delivered by the HandiHaler®) Compared to Once Daily, Orally Inhaled, Co-administration of Placebo (Delivered by the Respimat® Inhaler) and Tiotropium 18µg (Delivered by the HandiHaler®) in Patients With Chronic Obstructive Pulmonary Disease (COPD)[ANHELTO TM 1]
Brief Summary: The overall objective of this study is to assess efficacy and safety of 12 weeks, once daily, orally inhaled co-administration of olodaterol 5 µg (delivered by the Respimat® Inhaler) and tiotropium (delivered by the Handihaler® as Spiriva Handihaler®), compared to tiotropium (Spiriva Handihaler®) monotherapy on lung function in patients with COPD.


Options:
A: Arm Label: QVA149; Type: EXPERIMENTAL; Interventions: Drug: QVA149, Drug: Salbutamol/albuterol | Arm Label: NVA237; Type: ACTIVE_COMPARATOR; Interventions: Drug: NVA237, Drug: Salbutamol/albuterol | Arm Label: open-label tiotropium; Type: ACTIVE_COMPARATOR; Interventions: Drug: tiotropium, Drug: Salbutamol/albuterol | Intervention Type: DRUG; Name: QVA149; Assigned to Arm(s): QVA149 | Intervention Type: DRUG; Name: NVA237; Assigned to Arm(s): NVA237 | Intervention Type: DRUG; Name: tiotropium; Assigned to Arm(s): open-label tiotropium | Intervention Type: DRUG; Name: Salbutamol/albuterol; Assigned to Arm(s): NVA237, QVA149, open-label tiotropium
B: Arm Label: Olodaterol and Tiotropium; Type: EXPERIMENTAL; Interventions: Drug: Olodaterol, Drug: Tiotropium | Arm Label: Placebo and Tiotropium; Type: OTHER; Interventions: Drug: Tiotropium, Drug: Placebo matching Olodaterol | Intervention Type: DRUG; Name: Tiotropium; Assigned to Arm(s): Placebo and Tiotropium | Intervention Type: DRUG; Name: Placebo matching Olodaterol; Assigned to Arm(s): Placebo and Tiotropium | Intervention Type: DRUG; Name: Olodaterol; Assigned to Arm(s): Olodaterol and Tiotropium | Intervention Type: DRUG; Name: Tiotropium; Assigned to Arm(s): Olodaterol and Tiotropium
C: Arm Label: GSK573719/GW642444; Type: EXPERIMENTAL; Interventions: Drug: 62.5/25mcg | Arm Label: GSK573719; Type: EXPERIMENTAL; Interventions: Drug: 62.5mcg | Arm Label: GW642444; Type: EXPERIMENTAL; Interventions: Drug: 25mcg | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: 62.5/25mcg; Assigned to Arm(s): GSK573719/GW642444 | Intervention Type: DRUG; Name: 62.5mcg; Assigned to Arm(s): GSK573719 | Intervention Type: DRUG; Name: 25mcg; Assigned to Arm(s): GW642444 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
D: Arm Label: olodaterol (BI 1744) low and placebo; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) low, Drug: Placebo, Device: Respimat | Arm Label: olodaterol (BI 1744) low and low tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) low, Drug: low tiotropium bromide, Device: Respimat | Arm Label: olodaterol (BI 1744) low and medium tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) low, Drug: medium tiotropium bromide, Device: Respimat | Arm Label: olodaterol (BI 1744) low and high tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) low, Drug: high tiotropium bromide, Device: Respimat | Arm Label: olodaterol (BI 1744) high and placebo; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) high, Drug: Placebo, Device: Respimat | Arm Label: Olodaterol (BI 1744) high and low tio; Type: EXPERIMENTAL; Interventions: Drug: low tiotropium bromide, Drug: olodaterol (BI 1744) high, Device: Respimat | Arm Label: Olodaterol (BI 1744) high and medium tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) high, Drug: medium tiotropium bromide, Device: Respimat | Arm Label: Olodaterol (BI 1744) high and high tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) high, Drug: high tiotropium bromide, Device: Respimat | Intervention Type: DRUG; Name: olodaterol (BI 1744) low; Assigned to Arm(s): olodaterol (BI 1744) low and high tio, olodaterol (BI 1744) low and low tio, olodaterol (BI 1744) low and medium tio, olodaterol (BI 1744) low and placebo | Intervention Type: DRUG; Name: low tiotropium bromide; Assigned to Arm(s): Olodaterol (BI 1744) high and low tio, olodaterol (BI 1744) low and low tio | Intervention Type: DRUG; Name: olodaterol (BI 1744) high; Assigned to Arm(s): Olodaterol (BI 1744) high and high tio, Olodaterol (BI 1744) high and low tio, Olodaterol (BI 1744) high and medium tio, olodaterol (BI 1744) high and placebo | Intervention Type: DRUG; Name: medium tiotropium bromide; Assigned to Arm(s): Olodaterol (BI 1744) high and medium tio, olodaterol (BI 1744) low and medium tio | Intervention Type: DRUG; Name: high tiotropium bromide; Assigned to Arm(s): Olodaterol (BI 1744) high and high tio, olodaterol (BI 1744) low and high tio | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): olodaterol (BI 1744) high and placebo, olodaterol (BI 1744) low and placebo | Intervention Type: DEVICE; Name: Respimat; Assigned to Arm(s): Olodaterol (BI 1744) high and high tio, Olodaterol (BI 1744) high and low tio, Olodaterol (BI 1744) high and medium tio, olodaterol (BI 1744) high and placebo, olodaterol (BI 1744) low and high tio, olodaterol (BI 1744) low and low tio, olodaterol (BI 1744) low and medium tio, olodaterol (BI 1744) low and placebo

Answer: B