Please select the eligibility criteria that correspond to the clinical trial below.
Title: Effect of Weight-loss Diet Strategies and Exercise on Dynamics of Body Fat Depots and Metabolic Rate
Brief Summary: The investigators hypothesize that differential dynamics in fat depots in response to two opposing dietary strategies mediate the beneficial metabolic effects during weight loss and regain phases.


Options:
A: Inclusion Criteria:

* Elevated waist circumference:

  * Men: \> 40 inches (102 cm)
  * Women\> 35 inches (88 cm)
* Poor dieters with TG\>150mg/dL and high-density-lipoprotein cholesterol \[HDL-c\] \<40 mg/dL for men and \<50 mg/dL for women

Exclusion Criteria:

* Pregnant or lactating women
* Serum creatinine LT 2 mg/dl
* Disturbed liver function (LT 3 fold level of ALT and AST enzymes)
* Active cancer
* Individuals who cannot start physical activity in the gym
* Individuals that are highly physically active (more than 4 hours/week)
* Active in other nutritional trial
B: Inclusion Criteria:

* Men or women aged 22 - 75 years, any race/ethnicity
* BMI of 30 - 45 k/m2
* Willing and able to provide informed consent

Exclusion Criteria:

* History of self-reported clinical CVD (angina/myocardial infarction, coronary revascularization, heart failure, stroke/transient ischemic attack, peripheral arterial disease)
* Medical condition in which a low-carbohydrate diet may not be advised (diabetes, renal disease, cancer requiring treatment during the past year, osteoporosis, untreated thyroid disease, gout)
* Current use of more than 2 antihypertensive or more than 2 cholesterol-lowering medications
* For women, current pregnancy or breastfeeding or plans to become pregnant during the study period
* Consumption of more than 21 alcoholic beverages per week
* Currently on a diet or using prescription weight loss medications, underwent weight loss surgery, and/or experienced weight loss \>15 pounds within 6 months of study entry
* Plans to move out of the study area (\>1 hour from study site) or difficulty to come to the study site
* Participation of another household member in the study; employees or persons living with employees of the study
* Participation in other lifestyle intervention trials currently
* At the discretion of the study coordinator
C: Inclusion Criteria:

* Body mass index 30 or greater
* Stable health
* Desire to lose weight
* Agrees to attend regular visits
* Access to telephone and reliable transportation
* Has a Veterans Affairs Medical Center (VAMC) provider

Exclusion Criteria:

* Certain chronic or unstable disease (kidney or liver disease, type 1 diabetes, hemoglobin A1c 12% or more, insulin use, unstable heart disease, transplant recipient, blood pressure 160/100 or greater, fasting blood triglycerides 600 or greater, LDL cholesterol 190 or greater)
* Pregnancy, breastfeeding, lack of birth control
* Active dementia, psychiatric illness, or substance abuse (past year)
* Weight loss therapy in previous month
* Pacemaker or defibrillator
* Enrolled in another study that might affect measurements
* Previously in study of low-carbohydrate or low-fat diet for weight loss
* Unable to complete all study measures
D: Inclusion Criteria:

* Body mass index between 30 and 40
* Live and work within 1 hour of the study site
* Stable psychological status

Exclusion Criteria:

* History of heart disease, heart attack, or stroke
* Blood pressure \> 140/90 mmHG
* Abnormal cholesterol levels
* Significant psychiatric illness
* Any medication that affects weight or metabolic rate
* Presence or history of a chronic disease that is known to affect appettite, food intake, or metabolism (i.e. diabetes, thyroid disease or cancer).
* Currently using antidepressants, steroids, tobacco or illegal drugs
* Pregnant, breastfeeding, or planning pregnancy
* 10 lb change in weight within 6 months of study entry
* History of malignant arrhythmias or cerebrovascular, renal, or hepatic disease
* History of protein wasting diseases or gout
* Severe arthritis
* Osteoperosis
* Certain types of hormone replacement therapy
* Currently following a vegetarian diet

Answer: A