Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Outcome Following Truncation of Asparaginase in the NOPHO ALL2008 Protocol
Brief Summary: This study aimed to investigate the outcome of patients who had their asparaginase treatment truncated in the NOPHO ALL2008 protocol.


Options:
A: Arm Label: I; Type: EXPERIMENTAL; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: prednisone, Drug: Vincristine | Arm Label: II; Type: EXPERIMENTAL; Interventions: Drug: dexamethasone, Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: Vincristine | Arm Label: Reintensification Arm I; Type: EXPERIMENTAL; Interventions: Drug: Asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: doxorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: thioguanine, Drug: Vincristine | Arm Label: Reintensification Arm II; Type: EXPERIMENTAL; Interventions: Drug: Asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: doxorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: thioguanine, Drug: Vincristine | Arm Label: Reintensification Arm III; Type: EXPERIMENTAL; Interventions: Drug: Asparaginase, Drug: cytarabine, Drug: doxorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: Vincristine | Arm Label: Reintensification Arm IV; Type: EXPERIMENTAL; Interventions: Drug: Etoposide, Drug: Ifosfamide, Drug: Methotrexate, Drug: Vincristine, Drug: Vindesine | Arm Label: Reintensification Arm V; Type: EXPERIMENTAL; Interventions: Drug: Etoposide, Drug: Ifosfamide, Drug: Methotrexate, Drug: Vincristine, Drug: Vindesine | Intervention Type: DRUG; Name: dexamethasone; Assigned to Arm(s): II | Intervention Type: DRUG; Name: asparaginase; Assigned to Arm(s): I, II | Intervention Type: DRUG; Name: Asparaginase; Assigned to Arm(s): Reintensification Arm I, Reintensification Arm II, Reintensification Arm III | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II | Intervention Type: DRUG; Name: cytarabine; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II, Reintensification Arm III | Intervention Type: DRUG; Name: daunorubicin; Assigned to Arm(s): I, II | Intervention Type: DRUG; Name: doxorubicin; Assigned to Arm(s): Reintensification Arm I, Reintensification Arm II, Reintensification Arm III | Intervention Type: DRUG; Name: Etoposide; Assigned to Arm(s): Reintensification Arm IV, Reintensification Arm V | Intervention Type: DRUG; Name: Ifosfamide; Assigned to Arm(s): Reintensification Arm IV, Reintensification Arm V | Intervention Type: DRUG; Name: mercaptopurine; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II, Reintensification Arm III | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II, Reintensification Arm III, Reintensification Arm IV, Reintensification Arm V | Intervention Type: DRUG; Name: prednisone; Assigned to Arm(s): I | Intervention Type: DRUG; Name: thioguanine; Assigned to Arm(s): Reintensification Arm I, Reintensification Arm II | Intervention Type: DRUG; Name: Vincristine; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II, Reintensification Arm III, Reintensification Arm IV, Reintensification Arm V | Intervention Type: DRUG; Name: Vindesine; Assigned to Arm(s): Reintensification Arm IV, Reintensification Arm V
B: Arm Label: SC-PEG (Arm A); Type: ACTIVE_COMPARATOR; Interventions: Drug: SC-PEG | Arm Label: Oncaspar (Arm B); Type: ACTIVE_COMPARATOR; Interventions: Drug: Oncaspar | Intervention Type: DRUG; Name: SC-PEG; Assigned to Arm(s): SC-PEG (Arm A) | Intervention Type: DRUG; Name: Oncaspar; Assigned to Arm(s): Oncaspar (Arm B)
C: Arm Label: Exposed; Type: N/A; Interventions: N/A | Arm Label: Unexposed; Type: N/A; Interventions: N/A
D: Arm Label: Intramuscular native E coli L-asparaginase (IM-EC); Type: ACTIVE_COMPARATOR; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: dexamethasone, Drug: dexrazoxane hydrochloride, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: leucovorin calcium, Drug: mercaptopurine, Drug: methotrexate, Drug: methylprednisolone, Drug: prednisolone, Drug: therapeutic hydrocortisone, Drug: vincristine sulfate, Radiation: radiation therapy | Arm Label: Intravenous PEG-asparaginase (IV-PEG); Type: EXPERIMENTAL; Interventions: Drug: cyclophosphamide, Drug: cytarabine, Drug: dexamethasone, Drug: dexrazoxane hydrochloride, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: leucovorin calcium, Drug: mercaptopurine, Drug: methotrexate, Drug: methylprednisolone, Drug: pegaspargase, Drug: prednisolone, Drug: therapeutic hydrocortisone, Drug: vincristine sulfate, Radiation: radiation therapy | Intervention Type: DRUG; Name: asparaginase; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC) | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: cytarabine; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: dexamethasone; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: dexrazoxane hydrochloride; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: etoposide; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: leucovorin calcium; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: mercaptopurine; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: methotrexate; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: methylprednisolone; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: pegaspargase; Assigned to Arm(s): Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: prednisolone; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: therapeutic hydrocortisone; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: vincristine sulfate; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG)

Answer: C