Please select the eligibility criteria that correspond to the clinical trial below.
Title: TRuSST: Treatment of Social Cognition in Schizophrenia Trial
Brief Summary: This study is a multi-site, prospective, parallel arm, double-blind, randomized, controlled clinical trial to assess the efficacy of an experimental software program targeting social cognitive abilities versus a computer-based software control. Both the study and the software being investigated meet the criteria of Non-Significant Risk.


Options:
A: Inclusion Criteria:

* Demonstrates adequate decisional capacity to make a choice about participating in the research study
* Diagnosis of schizophrenia or schizoaffective disorder, as defined by DSM-IV-TR criteria and confirmed by the Structured Clinical Interview for DSM-IV (SCID)
* Positive and Negative Syndrome Scale (PANSS) hallucinatory behavior, unusual thought content, and conceptual disorganization ratings of no greater than moderately severe (i.e., item scores must be less than or equal to 5)
* Meets all of the following cognitive performance and English language criteria:

  1. Learned English before age 12
  2. Able to complete the baseline Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) validly, based on the judgment of the investigator
  3. Raw score of 37 or greater on the Wide Range Achievement Test, reading subtest, 3rd edition (WRAT-3), used to establish minimum sixth grade reading level and estimated premorbid IQ
* Able to state specific goals relevant to the intervention that participant would like to achieve
* Able to participate in the computerized intervention, based on the judgment of the investigator

Exclusion Criteria:

* Psychiatric hospitalization within 8 weeks of random assignment
* Adjustment to antipsychotic treatment within 4 weeks of random assignment
* Currently taking an anticholinergic medication
* DSM-IV diagnosis of alcohol or substance abuse (other than nicotine) within the last month or a DSM-IV diagnosis of alcohol or substance dependence (other than nicotine) within the last 6 months
* History of mental retardation, pervasive developmental disorder, or other neurological disorder (such as a traumatic brain injury, epilepsy, or Parkinson 's disease)
B: Inclusion Criteria:

1. Subjects must be between 18 and 65 years old, inclusive, at the time of study screening
2. Subjects must have a diagnosis of schizophrenia as defined by an interview.
3. Subjects must demonstrate adequate decisional capacity, in the judgment of the consenting study staff member, to make a choice about participating in this research study.
4. Subjects must have been clinically stable (non-acute) for 8 weeks prior to consent; in the judgment of the Site Principal Investigator.
5. Subjects must have been maintained on a stable treatment of antipsychotics and/or other concomitant psychotropic treatment for at least 6 weeks prior to consent.
6. Subjects must have learned English before the age of 12 to ensure valid neuropsychological results.
7. Subjects must have the visual, auditory, and motor capacity to use the computerized intervention in the judgment of the consenting study staff person.
8. Subjects must have no more than a moderately severe rating on hallucinations and unusual thought content.

Exclusion Criteria:

1. Subjects should not have had a psychiatric hospitalization in the 8 weeks prior to consent.
2. Subjects who appear to be intoxicated or under the influence of a controlled substance on any day of assessment must be rescheduled or discontinued based upon the discretion of the site staff evaluator.
3. Subjects should not have a history of mental retardation or pervasive developmental disorder; or other neurological disorder (e.g., Traumatic Brain Injury, epilepsy, Parkinson's Disease.)
4. Subjects should not have been treated within 3 years of the date of consent with a computer-based cognitive training program manufactured by Posit Science.
5. Subjects should not be participating in a concurrent clinical trial that, in the judgment of the Site Principal Investigator, could affect the outcome of this one.
6. Subjects must not show suicidal ideation or behaviors.
C: Inclusion Criteria:

* Participant in VA work services
* Chronic and disabling psychiatric illness

Exclusion Criteria:

* Neurological Disease that may affect cognition
* Primary substance abuse
* Developmental Disability
D: Inclusion Criteria:

* Diagnosis of schizophrenia or schizoaffective disorder
* Good general health
* First language is English
* Clinically stable (i.e., no inpatient hospital stays for 3 months prior to study entry; on stable doses of medication)

Exclusion Criteria:

* History of substance abuse within 6 months prior to study entry
* Neurological disorder
* Any metal in the body, or claustrophobia

Answer: B