Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Standard Versus Transepithelial Corneal Crosslinking for Treatment of Progressive Keratoconus
Brief Summary: The gold standard corneal crosslinking (CXL) technique involves the initial step of epithelial removal, in order to achieve a sufficient treatment effect (meaning: stabilisation of progressive keratoconus (KC). Our aim is to evaluate the effects of transepithelial CXL (TE-CXL), whereby the epithelium is left intact and the cornea is instead treated by a solution composed of 0.1% riboflavin, combined with enhancers, after which standard CXL is performed. This solution seems to facilitate riboflavin penetration into the corneal stroma through the intact epithelium. The investigators expect to achieve a similar effect of TE-CXL with the advantage of a faster healing time and less risk of infections.


Options:
A: Arm Label: epithelium off CXL; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Transepithelial versus epithelium-off CXL, Drug: Isotonic riboflavin | Arm Label: Ricrolin TE CXL; Type: EXPERIMENTAL; Interventions: Procedure: Transepithelial versus epithelium-off CXL, Drug: Ricrolin TE | Intervention Type: PROCEDURE; Name: Transepithelial versus epithelium-off CXL; Assigned to Arm(s): Ricrolin TE CXL, epithelium off CXL | Intervention Type: DRUG; Name: Ricrolin TE; Assigned to Arm(s): Ricrolin TE CXL | Intervention Type: DRUG; Name: Isotonic riboflavin; Assigned to Arm(s): epithelium off CXL
B: Arm Label: 30 minute light duration; Type: ACTIVE_COMPARATOR; Interventions: Drug: riboflavin, Device: UVX Light | Arm Label: 45 minute light duration; Type: ACTIVE_COMPARATOR; Interventions: Device: UVX Light | Intervention Type: DRUG; Name: riboflavin; Assigned to Arm(s): 30 minute light duration | Intervention Type: DEVICE; Name: UVX Light; Assigned to Arm(s): 30 minute light duration, 45 minute light duration
C: Arm Label: Bacterial ulcer cross-linking; Type: EXPERIMENTAL; Interventions: Procedure: Corneal Cross-linking | Arm Label: Bacterial ulcer control; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Corneal Cross-linking | Arm Label: Fungal ulcer cross-linking plus natamycin; Type: EXPERIMENTAL; Interventions: Procedure: Corneal Cross-linking, Drug: Anti Fungal Drug | Arm Label: Fungal ulcer control with natamycin; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Corneal Cross-linking, Drug: Anti Fungal Drug | Arm Label: Fungal ulcer cross-linking plus amphotericin; Type: EXPERIMENTAL; Interventions: Procedure: Corneal Cross-linking, Drug: Anti Fungal Drug | Arm Label: Fungal ulcer control with amphotericin; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Corneal Cross-linking, Drug: Anti Fungal Drug | Intervention Type: PROCEDURE; Name: Corneal Cross-linking; Assigned to Arm(s): Bacterial ulcer control, Bacterial ulcer cross-linking, Fungal ulcer control with amphotericin, Fungal ulcer control with natamycin, Fungal ulcer cross-linking plus amphotericin, Fungal ulcer cross-linking plus natamycin | Intervention Type: DRUG; Name: Anti Fungal Drug; Assigned to Arm(s): Fungal ulcer control with amphotericin, Fungal ulcer control with natamycin, Fungal ulcer cross-linking plus amphotericin, Fungal ulcer cross-linking plus natamycin
D: Arm Label: Active Treatment Arm; Type: EXPERIMENTAL; Interventions: Drug: Riboflavin, Drug: Dextran, Device: UVA Light Source | Arm Label: Control Treatment Arm; Type: ACTIVE_COMPARATOR; Interventions: Drug: Riboflavin, Drug: Dextran | Intervention Type: DRUG; Name: Riboflavin; Assigned to Arm(s): Active Treatment Arm, Control Treatment Arm | Intervention Type: DRUG; Name: Dextran; Assigned to Arm(s): Active Treatment Arm, Control Treatment Arm | Intervention Type: DEVICE; Name: UVA Light Source; Assigned to Arm(s): Active Treatment Arm

Answer: A