Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomised Phase II Study Of Nintedanib (BIBF1120) Compared To Chemotherapy in Patients With Recurrent Clear Cell Carcinoma Of The Ovary Or Endometrium
Brief Summary: The trial will recruit up to 120 patients; 90 with ovarian clear cell carcinoma and up to 30 with endometrial clear cell carcinoma. Patients will be randomised between chemotherapy and Nintedanib 200mg twice daily oral administration (PO) continuously. The primary diagnosis must be histologically confirmed and central pathological review of the presenting tumour or biopsy of relapsed disease must find at least 50% clear cell carcinoma with no serous differentiation


Options:
A: Arm Label: Paclitaxel & Carboplatin; Type: ACTIVE_COMPARATOR; Interventions: Drug: Paclitaxel, Drug: Carboplatin | Arm Label: Paclitaxel & Carboplatin & Bevacizumab; Type: EXPERIMENTAL; Interventions: Drug: Bevacizumab, Drug: Paclitaxel, Drug: Carboplatin | Intervention Type: DRUG; Name: Bevacizumab; Assigned to Arm(s): Paclitaxel & Carboplatin & Bevacizumab | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): Paclitaxel & Carboplatin, Paclitaxel & Carboplatin & Bevacizumab | Intervention Type: DRUG; Name: Carboplatin; Assigned to Arm(s): Paclitaxel & Carboplatin, Paclitaxel & Carboplatin & Bevacizumab
B: Arm Label: Phase 3 -Active Treatment Arm; Type: EXPERIMENTAL; Interventions: Drug: AL3818, Drug: Paclitaxel, Drug: Pegylated Liposomal Doxorubicin (PLD), Drug: Topotecan | Arm Label: Phase 3-Control Treatment Arm; Type: OTHER; Interventions: Drug: Paclitaxel, Drug: Pegylated Liposomal Doxorubicin (PLD), Drug: Topotecan | Arm Label: Phase 1b: AL3818 plus carboplatin and paclitaxel; Type: EXPERIMENTAL; Interventions: Drug: Carboplatin, Drug: Paclitaxel, Drug: AL3818 | Arm Label: Phase 2a: AL3818 plus carboplatin and paclitaxel; Type: EXPERIMENTAL; Interventions: Drug: Carboplatin, Drug: Paclitaxel, Drug: AL3818 | Intervention Type: DRUG; Name: AL3818; Assigned to Arm(s): Phase 3 -Active Treatment Arm | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): Phase 3 -Active Treatment Arm, Phase 3-Control Treatment Arm | Intervention Type: DRUG; Name: Pegylated Liposomal Doxorubicin (PLD); Assigned to Arm(s): Phase 3 -Active Treatment Arm, Phase 3-Control Treatment Arm | Intervention Type: DRUG; Name: Topotecan; Assigned to Arm(s): Phase 3 -Active Treatment Arm, Phase 3-Control Treatment Arm | Intervention Type: DRUG; Name: Topotecan; Assigned to Arm(s): Phase 3 -Active Treatment Arm, Phase 3-Control Treatment Arm | Intervention Type: DRUG; Name: Carboplatin; Assigned to Arm(s): Phase 1b: AL3818 plus carboplatin and paclitaxel, Phase 2a: AL3818 plus carboplatin and paclitaxel | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): Phase 1b: AL3818 plus carboplatin and paclitaxel, Phase 2a: AL3818 plus carboplatin and paclitaxel | Intervention Type: DRUG; Name: AL3818; Assigned to Arm(s): Phase 1b: AL3818 plus carboplatin and paclitaxel, Phase 2a: AL3818 plus carboplatin and paclitaxel
C: Arm Label: Nintedanib; Type: EXPERIMENTAL; Interventions: Drug: Nintedanib | Arm Label: Chemotherapy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Paclitaxel, Drug: Pegylated Liposomal Doxorubicin (PLD), Drug: Topotecan, Drug: Carboplatin, Drug: Doxorubicin | Intervention Type: DRUG; Name: Nintedanib; Assigned to Arm(s): Nintedanib | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): Chemotherapy | Intervention Type: DRUG; Name: Pegylated Liposomal Doxorubicin (PLD); Assigned to Arm(s): Chemotherapy | Intervention Type: DRUG; Name: Topotecan; Assigned to Arm(s): Chemotherapy | Intervention Type: DRUG; Name: Carboplatin; Assigned to Arm(s): Chemotherapy | Intervention Type: DRUG; Name: Doxorubicin; Assigned to Arm(s): Chemotherapy
D: Arm Label: Arm A; Type: ACTIVE_COMPARATOR; Interventions: Drug: Paclitaxel | Arm Label: Arm B; Type: EXPERIMENTAL; Interventions: Drug: Cediranib, Drug: Olaparib | Arm Label: Arm C; Type: EXPERIMENTAL; Interventions: Drug: Cediranib, Drug: Olaparib | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): Arm A | Intervention Type: DRUG; Name: Cediranib; Assigned to Arm(s): Arm B, Arm C | Intervention Type: DRUG; Name: Olaparib; Assigned to Arm(s): Arm B, Arm C

Answer: C