Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Memory Aid - Computer Based Working Memory Training in Elderly With Mild Cognitive Impairment (MCI). A Randomized, Controlled Trial.
Brief Summary: Background:

Mild Cognitive Impairment (MCI) is a condition characterized by memory problems more severe than normal cognitive changes due to old age, and less severe than dementia. Reduced working memory (WM) is regarded as one of the core symptoms of an MCI-condition. Recent studies have indicated that WM can be improved trough computer based training.

Objectives:

The objective of the study is to evaluate if working memory training is effective in improving working memory in elderly MCI-patients. Further, to evaluate if cognitive training relates to structural changes in the white and gray matter of the brain, assessed by structural Magnetic Resonance Imaging. Cognitive phenotypes related to memory impairment and progression to dementia will also be investigated.

Patients and Methods:

The proposed study is a blinded, randomized and controlled trail that will include 90 elderly patients from a Memory Clinic diagnosed with MCI. The groups will be randomized to either training or a placebo version. The intervention is computerized working memory training performed for 45 minutes over 25 sessions. Neuropsychological assessment and structural MRI will be performed before, 6 and 12 months after training.

Relevance:

Currently there is no known treatment available for mild memory impairment/MCI, and few studies on specific cognitive training in MCI-patients have been performed. The proposed study has received funding from a Norwegian Health Region. If computer based training results in positive changes to memory functions in MCI patients this may represent a new, cost-effective treatment. Secondly, evaluation of training induced structural changes to grey or white matter may improve our understanding of the mechanisms behind effective cognitive interventions in MCI patients.


Options:
A: Arm Label: Exercises+CognitiveTraining+Vitamin D3; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Vitamin D3, Other: Exercises (E), Other: Cognitive Training (CT) | Arm Label: Exercises+CognitiveTraining+Placebo D3; Type: EXPERIMENTAL; Interventions: Other: Exercises (E), Other: Cognitive Training (CT), Other: placebo D3 | Arm Label: Exercises+Control CogTraining+Vitamin D3; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Vitamin D3, Other: Exercises (E), Other: control cognitive training | Arm Label: Exercises+Control CogTraining+Placebo D3; Type: EXPERIMENTAL; Interventions: Other: Exercises (E), Other: placebo D3, Other: control cognitive training | Arm Label: Placebo exercise+Control Cog+Placebo D3; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo D3, Other: control cognitive training, Other: Placebo exercise | Intervention Type: DIETARY_SUPPLEMENT; Name: Vitamin D3; Assigned to Arm(s): Exercises+CognitiveTraining+Vitamin D3, Exercises+Control CogTraining+Vitamin D3 | Intervention Type: OTHER; Name: Exercises (E); Assigned to Arm(s): Exercises+CognitiveTraining+Placebo D3, Exercises+CognitiveTraining+Vitamin D3, Exercises+Control CogTraining+Placebo D3, Exercises+Control CogTraining+Vitamin D3 | Intervention Type: OTHER; Name: Cognitive Training (CT); Assigned to Arm(s): Exercises+CognitiveTraining+Placebo D3, Exercises+CognitiveTraining+Vitamin D3 | Intervention Type: OTHER; Name: placebo D3; Assigned to Arm(s): Exercises+CognitiveTraining+Placebo D3, Exercises+Control CogTraining+Placebo D3, Placebo exercise+Control Cog+Placebo D3 | Intervention Type: OTHER; Name: control cognitive training; Assigned to Arm(s): Exercises+Control CogTraining+Placebo D3, Exercises+Control CogTraining+Vitamin D3, Placebo exercise+Control Cog+Placebo D3 | Intervention Type: OTHER; Name: Placebo exercise; Assigned to Arm(s): Placebo exercise+Control Cog+Placebo D3
B: Arm Label: Computerized Working Memory Training.; Type: SHAM_COMPARATOR; Interventions: Device: Computerized Working Memory Training. | Intervention Type: DEVICE; Name: Computerized Working Memory Training.; Assigned to Arm(s): Computerized Working Memory Training.
C: Arm Label: cognitive training; Type: EXPERIMENTAL; Interventions: Device: CogniFit Personal Coach® | Intervention Type: DEVICE; Name: CogniFit Personal Coach®; Assigned to Arm(s): cognitive training
D: Arm Label: LLM; Type: EXPERIMENTAL; Interventions: Other: LLM | Arm Label: PTC; Type: EXPERIMENTAL; Interventions: Other: FFA | Arm Label: CTC; Type: EXPERIMENTAL; Interventions: Other: Brain Fitness | Arm Label: Passive; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Active; Type: ACTIVE_COMPARATOR; Interventions: Other: VideoGrade | Intervention Type: OTHER; Name: LLM; Assigned to Arm(s): LLM | Intervention Type: OTHER; Name: FFA; Assigned to Arm(s): PTC | Intervention Type: OTHER; Name: Brain Fitness; Assigned to Arm(s): CTC | Intervention Type: OTHER; Name: VideoGrade; Assigned to Arm(s): Active

Answer: B