Please select the eligibility criteria that correspond to the clinical trial below.
Title: Mindfulness-Based Stress Management Program and Omega-3 Fatty Acids to Maintain Healthy Mental State in Hospital Nurses: Multi-Center Factorial-Design Randomized Controlled Trial Happy Nurse Project
Brief Summary: The study is to explore the effectiveness of omega-3 fatty acids and mindfulness-based stress management program to maintain healthy mental state in hospital nurses. The participants will be junior nurses who work in inpatient wards and are not clinically depressed. The participants will be randomly allocated to four intervention arms: 1) Mindfulness-based stress management program plus omega-3 fatty acids pills ; 2) Mindfulness-based stress management program plus placebo pills; 3) Psychoeducation leaflet plus omega-3 fatty acids pills; and 4) Psychoeducation leaflet plus placebo pills. Thirty participants will be allocated to each arm. These interventions will terminate until three months from registration for each participant.

Information about depression and anxiety symptoms (primary outcome), insomnia, burnout, presenteeism, quality of life, sick leave, consultation about mental state of herself, and oxidative stress will be collected at 3 months, 6 months (primary time point) and 12 months from registration for each participant.


Options:
A: Inclusion Criteria:

* be 21-65 years old (age limitations for both police departments),
* demonstrate English fluency,
* be a sworn, full-time, active status law enforcement officer,
* agree to random assignment to condition, and
* be willing to complete assessments at multiple time points and attend intervention groups

Exclusion Criteria:

* previous participation in MBSR, MBRT or a similar mindfulness course,
* score in the severe range on brief screening measures of depression, suicidal ideation, alcohol use, or PTSD, or
* unable or unwilling to give written informed consent.
B: Inclusion Criteria:

* Work for inpatient wards in among four general hospitals in Tama region, Japan, including: National Center of Neurology and Psychiatry Hospital, National Disaster Medical Center, Tokyo Metropolitan Tama Medical Center, and Tama-Hokubu Medical Center
* Nurses without administration work
* Give written consent in the participation of the study

Exclusion Criteria:

* Have plans to take sick leave, leave for other reasons or retirement within 26 weeks from the entry to the study
* Take structured psychotherapy (e.g. cognitive behavioral therapy, interpersonal therapy, and brief psychodynamic therapy) at the entry
* See a physician regularly in order to treat any mood or anxiety disorders primarily at the entry
* Take antidepressants, mood stabilizers, anticonvulsants or antipsychotics at the entry
* Have taken nutrient supplement including omega-3 fatty acids for 4 or more weeks within 52 weeks from the entry
* Clinically depressed, based on the total score of 11 or more on the Hospital Anxiety and Depression Scale - Depression Subscale and the total score of 15 or more on the Primary Health Care Questionnaire
* Consume 4 times or more of fish as the main course of meal per week
* Take anticoagulant drugs at the entry or have previous history of stroke or myocardial infarction
* Judged ineligible by research coordinator due to any reason
C: Inclusion Criteria:

* UCSF surgical interns entering training. Do not meet exclusion criteria.

Exclusion Criteria:

* Current personal mindfulness practice, medications with CNS effects, lifetime history of a mental disorder, acute or chronic immune or inflammatory disorders, pregnancy, breast-feeding or implanted MRI-incompatible metal.
D: Inclusion Criteria:

* combat soldiers

Exclusion Criteria:

* Fluent Hebrew

Answer: B