Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Evaluation of the Safety and Immunogenicity of GSK Biologicals' HPV Vaccine 580299 When Administered in Healthy Females Aged 9 - 25 Years Using an Alternative Schedule and an Alternative Dosing as Compared to the Standard Schedule and Dosing
Brief Summary: Human Papillomavirus (HPV) infection has been established as a necessary cause of cervical cancer. GlaxoSmithKline (GSK) Biologicals has developed an HPV vaccine (580299) which targets the 2 most common oncogenic HPV types (HPV-16 and HPV-18), found in approximately 70% of all cervical cancers. In previous trials this vaccine has been found to be efficacious in the prevention of incident and persistent HPV-16/18 infections and associated cytological abnormalities and cervical dysplasia. In this partially-blind study, GSK Biologicals will evaluate the safety and immunogenicity of the HPV vaccine using an alternative schedule and an alternative dosing when administered in healthy young females aged 9 to 25 years, as compared to the standard HPV vaccine. The Protocol Posting has been updated in order to comply with the FDA Amendment Act, Sep 2007. The protocol posting has been updated following a protocol amendment.


Options:
A: Arm Label: Cervarix 1/Placebo Group; Type: EXPERIMENTAL; Interventions: Biological: Cervarix, Drug: Placebo | Arm Label: Cervarix 1/Placebo/Cervarix 1 Group; Type: EXPERIMENTAL; Interventions: Biological: Cervarix, Drug: Placebo | Arm Label: Cervarix 2/Placebo/Cervarix 2 Group; Type: EXPERIMENTAL; Interventions: Biological: Cervarix, Drug: Placebo | Arm Label: Cervarix 2 Group; Type: EXPERIMENTAL; Interventions: Biological: Cervarix | Intervention Type: BIOLOGICAL; Name: Cervarix; Assigned to Arm(s): Cervarix 1/Placebo Group, Cervarix 1/Placebo/Cervarix 1 Group, Cervarix 2 Group, Cervarix 2/Placebo/Cervarix 2 Group | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Cervarix 1/Placebo Group, Cervarix 1/Placebo/Cervarix 1 Group, Cervarix 2/Placebo/Cervarix 2 Group
B: Intervention Type: BIOLOGICAL; Name: HPV-16/18 L1/AS04; Assigned to Arm(s): N/A
C: Arm Label: Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine; Type: EXPERIMENTAL; Interventions: Biological: Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 20/40/40/20 | Arm Label: Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 40/40/40/40; Type: EXPERIMENTAL; Interventions: Biological: Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 40/40/40/40 | Arm Label: Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 80/80/40/80; Type: EXPERIMENTAL; Interventions: Biological: Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 80/80/40/80 | Arm Label: Placebo (mcg) (Aluminum Adjuvant) 225; Type: EXPERIMENTAL; Interventions: Biological: Placebo (mcg) (Aluminum Adjuvant)225 | Arm Label: Placebo (mcg) (Aluminum Adjuvant) 450; Type: EXPERIMENTAL; Interventions: Biological: Placebo (mcg) (Aluminum Adjuvant) 450 | Intervention Type: BIOLOGICAL; Name: Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 20/40/40/20; Assigned to Arm(s): Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine | Intervention Type: BIOLOGICAL; Name: Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 40/40/40/40; Assigned to Arm(s): Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 40/40/40/40 | Intervention Type: BIOLOGICAL; Name: Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 80/80/40/80; Assigned to Arm(s): Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 80/80/40/80 | Intervention Type: BIOLOGICAL; Name: Placebo (mcg) (Aluminum Adjuvant)225; Assigned to Arm(s): Placebo (mcg) (Aluminum Adjuvant) 225 | Intervention Type: BIOLOGICAL; Name: Placebo (mcg) (Aluminum Adjuvant) 450; Assigned to Arm(s): Placebo (mcg) (Aluminum Adjuvant) 450
D: Arm Label: Cervarix Group; Type: EXPERIMENTAL; Interventions: Biological: CervarixTM | Arm Label: Placebo Group; Type: EXPERIMENTAL; Interventions: Other: Control | Intervention Type: BIOLOGICAL; Name: CervarixTM; Assigned to Arm(s): Cervarix Group | Intervention Type: OTHER; Name: Control; Assigned to Arm(s): Placebo Group

Answer: A