Please select the eligibility criteria that correspond to the clinical trial below.
Title: CANDIS -Targeted Treatment for Cannabis Disorders
Brief Summary: The purpose of this study is to develop a modular treatment program for cannabis use disorders and the evaluation of the effectiveness in a controlled clinical study.


Options:
A: Inclusion Criteria:

* at least 18 years old
* receive medical care at one of the participating primary care clinics at Harborview Medical Center/University of Washington Medical Center
* will maintain care at the clinic for one year
* have a phone or easy access to phone, voicemail, or email
* used recreational drugs in the last 3 months
* used prescription medications not as prescribed in the last 3 months

Exclusion Criteria:

* participation in any formal substance abuse treatment programs in the last 30 days (excluding 12-step or self-help groups)
* terminal illness
B: Inclusion Criteria:

* motivation to change cannabis use
* age 16 or older
* current (12 mth) regular cannabis use (at least 2 days a week)
* informed consent to the study procedures and assessments

Exclusion Criteria:

* current alcohol or any illicit drug dependence syndrome according to DSM-IV other than due to cannabis
* lifetime history of any psychotic disorder
* current severe episode of Major depression
* current panic-agoraphobic disorder (severe)
* severe learning disability, brain damage or pervasive developmental disorder
* currently acute suicidality
* not fluent in german language
* any other current treatment for cannabis use disorders
C: Inclusion Criteria:

* age 16 or older
* lifetime diagnosis of cannabis abuse or cannabis dependence (according to the DSM-IV criteria
* current (4 wks) regular cannabis use (at least 2 days a week)
* persistent history of regular cannabis use of at least 3 years
* informed consent to the study procedures and assessments

Exclusion Criteria:

* current alcohol or any illicit drug dependence syndrome according to DSM-IV other than due to cannabis
* lifetime history of any psychotic disorder
* current severe episode of Major depression
* current panic-agoraphobic disorder (severe)
* severe learning disability, brain damage or pervasive developmental disorder
* currently acute suicidality
* not fluent in german language
* acute signs of intoxication at screening or baseline assessment due to opiates or any type of stimulants, causing cognitive impairments
* currently in treatment for cannabis-related disorders in other services
* current psychotropic medications with sedatives and antipsychotics
D: Inclusion Criteria:

* Cases and Controls must:

  * Be able to understand the study and provide written informed consent.
  * Be male or female 18 -35 years of age.
  * Be in generally good health
  * If female of childbearing potential, have a negative serum pregnancy test on study day

Cases must:

* Meet criteria for cannabis dependence as primary diagnosis as determined by the Substance Abuse module of SCID (Structured Clinical Interview for DSM-IV).
* Not currently seeking treatment for cannabis dependence.
* Have a positive urine drug test for cannabis on the study day
* Avoid alcohol and other recreational drug use (except cannabis and/or nicotine) for 48 h before testing.

Exclusion Criteria:

* Cases and Controls must not:

  * Be pregnant or lactating
  * Have implanted electrical medical device (e.g. pacemaker, vagal nerve stimulator)
  * Have non-secure metallic foreign bodies
  * Have met criteria for another axis 1 diagnosis in the past 6 months
  * Receive psychotropically active or vasoactive medications (within 6 weeks of screen day)
  * Have chronic medical illness
  * Have epilepsy
  * Have a history of head injury that required hospitalization
  * Have claustrophobia
  * Have orthopedic or other problems precluding them from performing exercise protocol
  * Have body mass index (BMI) less than 19 kg/m2
  * Weighing more than 275 pounds (MRI table limit)

Cases must not:

* Have current dependence, as determined by the SCID, on any psychoactive substance other than nicotine and/or cannabinoid
* Have any serious medical or psychiatric illnesses and/or clinically significant symptoms, which in the judgment of the PI or his/her designee would make them unsafe, or would make compliance with the study protocol difficult or put the study staff at undue risk

Answer: C