Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study Comparing a 2.2mg 17 Beta-Estradiol/0.69mg Levonorgestrel Combination Transdermal Patch, and a 1mg 17 Beta-Estradiol Transdermal Patch With a Placebo Patch in Postmenopausal Women to Determine the Lowest Effective Dose of Estradiol for the Relief of Moderate to Severe Hot Flushes
Brief Summary: To determine the lowest effective dose of estradiol by comparing E2/LNG (2.2mg/0.69mg) and E2 (1.0mg) dose with placebo in decreasing the frequency and severity of moderate to severe hot flushes in postmenopausal women


Options:
A: Arm Label: Placebo transdermal three 90 μL sprays; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo transdermal three 90 μL sprays | Arm Label: Placebo transdermal two 90 μL sprays; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo transdermal two 90 μL sprays | Arm Label: Placebo transdermal one 90 μL spray; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo transdermal one 90 μL spray | Arm Label: Estradiol transdermal three 90 μL sprays; Type: ACTIVE_COMPARATOR; Interventions: Drug: Estradiol transdermal three 90 μL sprays | Arm Label: Estradiol transdermal two 90 μL sprays; Type: ACTIVE_COMPARATOR; Interventions: Drug: Estradiol transdermal spray, two 90 μL sprays | Arm Label: Estradiol transdermal one 90 μL spray; Type: ACTIVE_COMPARATOR; Interventions: Drug: Estradiol transdermal one 90 μL spray | Intervention Type: DRUG; Name: Estradiol transdermal one 90 μL spray; Assigned to Arm(s): Estradiol transdermal one 90 μL spray | Intervention Type: DRUG; Name: Estradiol transdermal spray, two 90 μL sprays; Assigned to Arm(s): Estradiol transdermal two 90 μL sprays | Intervention Type: DRUG; Name: Estradiol transdermal three 90 μL sprays; Assigned to Arm(s): Estradiol transdermal three 90 μL sprays | Intervention Type: DRUG; Name: Placebo transdermal two 90 μL sprays; Assigned to Arm(s): Placebo transdermal two 90 μL sprays | Intervention Type: DRUG; Name: Placebo transdermal three 90 μL sprays; Assigned to Arm(s): Placebo transdermal three 90 μL sprays | Intervention Type: DRUG; Name: Placebo transdermal one 90 μL spray; Assigned to Arm(s): Placebo transdermal one 90 μL spray
B: Arm Label: Arm 1; Type: ACTIVE_COMPARATOR; Interventions: Drug: Climara PRO (Estradiol / Levonorgestrel transdermal) | Arm Label: Arm 2; Type: ACTIVE_COMPARATOR; Interventions: Drug: Menostar (Estradiol transdermal) | Arm Label: Arm 3; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo transdermal | Intervention Type: DRUG; Name: Climara PRO (Estradiol / Levonorgestrel transdermal); Assigned to Arm(s): Arm 1 | Intervention Type: DRUG; Name: Menostar (Estradiol transdermal); Assigned to Arm(s): Arm 2 | Intervention Type: DRUG; Name: Placebo transdermal; Assigned to Arm(s): Arm 3
C: Intervention Type: DRUG; Name: estradiol gel; Assigned to Arm(s): N/A
D: Arm Label: Treatment 1; Type: EXPERIMENTAL; Interventions: Drug: Estradiol, Drug: Progesterone, Drug: Placebo | Arm Label: Treatment 2; Type: EXPERIMENTAL; Interventions: Drug: Estradiol, Drug: Progesterone, Drug: Placebo | Arm Label: Treatment 3; Type: EXPERIMENTAL; Interventions: Drug: Estradiol, Drug: Progesterone, Drug: Placebo | Arm Label: Treatment 4; Type: EXPERIMENTAL; Interventions: Drug: Estradiol, Drug: Progesterone, Drug: Placebo | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Estradiol; Assigned to Arm(s): Treatment 1, Treatment 2, Treatment 3, Treatment 4 | Intervention Type: DRUG; Name: Progesterone; Assigned to Arm(s): Treatment 1, Treatment 2, Treatment 3, Treatment 4 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo, Treatment 1, Treatment 2, Treatment 3, Treatment 4

Answer: B