Please select the eligibility criteria that correspond to the clinical trial below.
Title: Reducing Alcohol Exposed Pregnancy Risk
Brief Summary: The EARLY Randomized Controlled Trial (RCT) will test the finalized EARLY preventive intervention against one comparison and one control condition. Because prevention of Alcohol-exposed pregnancy (AEP) will be achieved whether woman change drinking OR contraception, the primary endpoints will be rates of risky drinking and ineffective contraception at six-month follow-up, in addition to dichotomously defined "successful outcome" that will be observed whenever a woman has sufficiently altered one or both of the behaviors that placed her at risk of Alcohol-Exposed Pregnancy (AEP). The goal is to identify a transferable intervention that effectively reduces behaviors that put women at risk for AEP and alcohol-related birth defects including FASD.


Options:
A: Inclusion Criteria:

* Both males and females aged at least 18 years.
* Willing to continue receiving care /be followed up at the IDI for the next 6 months.
* Willing to provide written informed consent.

Exclusion Criteria:

* Very sick with Karnofsky clinical performance score \< 50.
* Pregnant women
B: Inclusion Criteria:

* ages 18-44
* fertile
* can provide informed consent
* had vaginal intercourse with a man in the past 3 months
* uses ineffective or no contraception
* speaks and reads English
* reports drinking more than seven standard drinks per week on average or more than one binge drinking episode (more than 3 standard drinks on one occasion) during the past 3 months
* if opioid dependent with recent use, is enrolled in opiate agonist treatment
* planning to remain available for the follow-up period

Exclusion Criteria:

* pregnancy
* cognitive disorders including mental retardation, dementia, or active -psychosis that could impair ability to understand the intervention material or give informed consent
* current Major Depressive Disorder that could diminish responsiveness to interventions focused on promoting change
* currently opioid dependent with active use and not engaged in opiate agonist treatment
* concurrently participating in another behavioral intervention study during the study period targeting drinking or contraception efficacy that could interfere with or augment the intervention in the EARLY project.
C: Inclusion Criteria:

* Prescription drug abuse
* Prescription drug dependence
* Regular prescription drug consumption (\>60 times/last three months)

Exclusion Criteria:

* Current treatment for substance abuse problems
* Terminal illness
D: Inclusion Criteria:

* 18 years of age or older
* Arrived for a visit in primary care
* ASSIST Substance Specific Involvement Score of greater than or equal to 4 for subjects included in primary analyses; ASSIST Substance-Specific Involvement Scores of 2 or 3 for subjects included only in exploratory analyses
* No previous MASBIRT intervention in the past 3 months
* Fluent in English or Spanish
* Two contacts who can assist with locating the subject for follow-up
* Able to return to Boston Medical Center in the next 6 months for research study visits
* Not pregnant (because care systems and resources differ greatly for such subjects)
* Able to be interviewed by trained research staff (excluding those in acute discomfort or with significantly impaired cognition)

Exclusion Criteria:

* NOT 18 years of age or older
* NOT Arrived for a visit in primary care
* NO ASSIST Substance Specific Involvement Score of greater than or equal to 4 for subjects included in primary analyses; or NO ASSIST Substance-Specific Involvement Scores of 2 or 3 for subjects included only in exploratory analyses
* ANY previous MASBIRT intervention in the past 3 months
* NOT Fluent in English or Spanish
* FEWER THAN two contacts who can assist with locating the subject for follow-up
* NOT able to return to Boston Medical Center in the next 6 months for research study visits
* Pregnant (because care systems and resources differ greatly for such subjects)
* UN-Able to be interviewed by trained research staff (excluding those in acute discomfort or with significantly impaired cognition)

Answer: B