Please select the eligibility criteria that correspond to the clinical trial below.
Title: Randomized Clinical Trial of Intensive Computer-based Cognitive Remediation in Recent-onset Schizophrenia
Brief Summary: The aim of this study is to investigate the efficacy of neuroscience-guided computerized cognitive training exercises on the remediation of cognitive deficits and symptoms associated with recent-onset schizophrenia and to examine the influence of subject characteristics, brain structure and function, and pharmacotherapy on the response to remediation.


Options:
A: Inclusion Criteria:

* meet SIPS criteria for schizophrenia prodrome

Exclusion Criteria:

* history of psychosis
B: Inclusion Criteria:

* Clinical diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
* First psychotic episode within the last 3 years
* Good general physical health
* Age between 12-35
* Is fluent and proficient in the English language
* Achieved clinical stability (e.g., outpatient status for at least 3 months before study entry; on stable doses of medication for at least 1 month before study entry
* Minors must have parental/legal guardian consent to participate

Exclusion Criteria:

* Any neurological disorder
* History of psychoactive substance abuse in the past 6 months
C: Inclusion Criteria:

* Age 18-40 yrs.
* Fulfill criteria for being at Ultra-High Risk of psychosis (defined by one or more of the following):

  * Vulnerability (Trait and State Risk Factor) Group: Individuals with a combination of a trait risk factor (schizotypal personality disorder or a family history of psychotic disorder in a first degree relative) and a significant deterioration in functioning, or sustained low functioning during the past year.
  * Attenuated Psychotic Symptoms (APS) Group: Individuals with sub-threshold (intensity or frequency) positive psychotic symptoms. The symptoms must have been present during the past year.
  * Brief Limited Intermittent Psychotic Symptoms Group (BLIPS): Individuals with a recent history of frank psychotic symptoms that resolved spontaneously (without antipsychotic medication) within one week. The symptoms must have been present during the past year.
* Provided informed consent.

Exclusion Criteria:

* Past history of a treated or untreated psychotic episode of one week's duration or longer
* Psychiatric symptoms that are explained by a physical illness with psychotropic effect or acute intoxication (e.g., cannabis use).
* Diagnosis of a serious developmental disorder, e.g,. Asperger's syndrome
* Currently receiving treatment with metylphenidate.
* Rejects providing informed consent.
D: Inclusion Criteria:

1. General criteria

   * Age between 17 and 36 years
   * male or female, in- or outpatients
   * written informed consent, for patients below 18 years also signed by their parents
2. Special criteria (presented within the last three months prior to the study)

   1. Self-experienced neuropsychological deficits (basic symptoms)

      * Thought interferences
      * Compulsory like perseverance of thoughts
      * Thought pressure
      * Thought blockages
      * Disturbances of receptive language, either heard or read
      * Decreased ability to discriminate between ideas and perception, fantasy and true memories
      * Unstable ideas of reference (subject-centrism)
      * Derealisation
      * Visual perceptual disturbances (blurred vision, transitory blindness, partial seeing, hypersensitivity of light, etc..)
      * Acoustic perceptual disturbances (hypersensitivity to sounds or noise (hypersensitivity to sounds or noise, acoasms, etc.) AND/OR
   2. Reduction in the Global Assessment of Functioning Score (DSM IV) of at least 30 points (within the past year) and at least one of the following risk factors:

      * First-degree relative with a lifetime-diagnosis of schizophrenia or
      * a schizophrenia spectrum disorder
      * Pre-or perinatal complications

Exclusion Criteria:

* Attenuated or transient positive symptomes
* Present or past diagnosis of a schizophrenic, schizophreniform, schizoaffective, delusional or bipolar according to DSM IV
* Present or past diagnosis a brief psychotic disorder according to DSM IV with a duration of more than one week or within the last 4 weeks regardless of its duration
* Diagnosis of delirium, dementia, amnestic or other cognitive disorder, mental retardation psychiatric disorder due to a somatic factor or related to the consumption of psychotropic substances according DSM IV
* Alcohol- or drug abuse within the last three months prior to inclusion according to DSM IV
* Deases of the central nervous system (inflammatory, traumatic, epilepsy etc.)

Answer: B