Please select the eligibility criteria that correspond to the clinical trial below.
Title: The PAL Trial (Physical Activity and Lymphedema)
Brief Summary: The purpose of the PAL trial is to increase the understanding of the experiences of long-term breast cancer survivors.

Study hypothesis: Strength training will not increase the rate of lymphedema or worsen lymphedema as compared to the non-exercising control participants.


Options:
A: Inclusion Criteria:

* Diagnosis of breast, colorectal or prostate cancer
* Completion of primary treatment
* Ability to participate physically in the activities offered in the intervention

Exclusion Criteria:

* Acute need for treatment
* Terminal cancer phase
B: Inclusion Criteria:

* Women without lymphedema must be 1-5 years post breast cancer diagnosis
* Women with lymphedema must be 1-15 years post breast cancer diagnosis
* Women with lymphedema must have stable lymphedema. ONE of the following:

  * 0-40\>10% girth volume difference between the affected and non- affected limb for a non-dominant arm
  * 6-40% girth volume difference between the affected and non- affected limb for a dominant arm inter-limb discrepancy in volume or circumference at the point of greatest visible difference OR swelling or obscuration of anatomic architecture upon close inspection OR pitting edema.

    * 2 cm circumference difference
  * A prior clinical diagnosis of lymphedema and having had any prior intensive lymphedema therapy on the affected arm

As well as ALL of the following four conditions:

* Women with Lymphedema must have ALL of the following:

  * No recorded arm girth change of 15% or greater within the three months.
  * No more than one lymphedema related infection requiring antibiotics within the past 3 months.
  * Participation in all Activities of Daily Living (ADLs) without lymphedema exacerbation for the past 3 months.

Exclusion Criteria:

* For ALL participants (with and without lymphedema)

  * No medical conditions or medications that would prohibit participation in an exercise program or would negatively impact our ability to test our primary aims
  * Not morbidly obese (body mass index \>50 kg/m2)
  * No plans for additional (e.g. reconstructive) surgery during the study period
  * No bilateral breast cancers (because this prohibits our ability to assess the primary outcome of interest)
  * No strength training or other upper body resistive exercise within the past year
  * Not planning to move away from the area over the next year
  * Not pregnant or lactating or planning to become pregnant during the study
  * Among women who have given birth: at least 6 months post pregnancy and at least 3 months post lactation
C: Inclusion Criteria:

* Have been diagnosed with breast, lung or colorectal cancer in the previous 8 weeks
* Are to receive oncologic care at the Albert Einstein Cancer Center (AECC)
* Have a life-expectancy of at least 6 months
* Are either English- or Spanish-speaking
* Do not practice yoga regularly (\> 1 month)
* Receive medical clearance by oncologic personnel on the study

Exclusion Criteria:

* Eastern Cooperative Oncology Group performance status \>= 3
* Existence of any of the following:

  * Seizure disorder
  * Musculoskeletal conditions
  * Heart problems
  * Major psychiatric disorder
D: DISEASE CHARACTERISTICS:

* Stage 0-IIIA breast cancer survivor
* Completed cancer treatment within the past 36 months (except for tamoxifen/aromatase inhibitors)

  * At least 2 months since prior surgery, adjuvant therapy, or radiotherapy, whichever occurred last
* Women who are not currently practicing yoga and have not participated in any of the following activities:

  * Meditation, tai chi, or related activities
  * Yoga or tai chi within the past 6 months
  * Had classes for or practiced yoga for more than 3 months
* Women who typically engage in a total of 5 or more hours of vigorous physical activity per week are not eligible
* No inflammatory breast cancer

PATIENT CHARACTERISTICS:

Inclusion criteria:

* Hemoglobin ≥ 10 g/dL (patients with a hemoglobin of \< 10 g/dL may be retested in 6 weeks after treatment of anemia and allowed to participate in study if blood counts recovered)
* Physically able to fully participate in yoga intervention

Exclusion criteria:

* Inability to comfortably get up and down from the floor 2-3 times in a session
* Breathing problems requiring use of oxygen
* Problems walking without a cane or walker assistance
* Prior knee or hip replacement with limited movement in the joint
* Inability to comfortably lie on the stomach
* Alcohol, or drug abuse
* Diagnosis of any of the following conditions:

  * Diabetes
  * Chronic obstructive pulmonary disease
  * Uncontrolled hypertension
  * Evidence of liver or kidney failure
  * Symptomatic ischemic heart disease
  * Significant visual or auditory problems
  * Mental disorder or cognitive impairment
  * Notable serious cardiovascular history (e.g., prior life-threatening abnormal heart rhythms)
  * Other medical conditions involving the immune system such as autoimmune and/or inflammatory diseases including rheumatoid arthritis and ulcerative colitis
* History of breast or any other cancer, except basal or squamous cell skin cancer

PRIOR CONCURRENT THERAPY:

* See Disease Characteristics
* No regular use of medications with major immunological consequences (e.g., steroids)

Answer: B