Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Late LTP-like Plasticity Effects of tDCS in Subacute Stroke Patients
Brief Summary: Rationale: About 80% of stroke patients suffer motor impairments, but current therapies have limited effects on motor recovery. Therefore, investigating new potential therapeutic approaches is crucial. Transcranial Direct Current Stimulation (tDCS) is a form of non-invasive electrical stimulation where a weak current is applied through electrodes over the scalp. This stimulation is known to (1) induce changes in neuronal excitability -which can last up to one day with late LTP-like plasticity protocols in a polarity and site-specific manner, and (2) facilitate motor learning and stroke recovery. So far, several pilot studies have reported beneficial results from tDCS in both subacute and chronic stroke patients, but it's still unclear how tDCS should be repeated over multiple days to optimally enhance recovery and training effects. Using a late LTP-like plasticity protocol could increase effectiveness of standard clinical care rehabilitation sessions and thus enhance the effects of rehabilitation. Therefore, the investigators want to investigate how late LTP-like plasticity tDCS affects rehabilitation in subacute stroke patients. The outcome of this study can provide important guidelines on effective motor therapy during stroke rehabilitation.

Objective: Identify the effect of late LTP-like plasticity on motor rehabilitation during the subacute phase after stroke.

Study design: Double-blinded, randomized between-subjects trials. Study population: Subacute stroke patients. Main study parameters/endpoints: The primary outcome measure is the upper limb motor function during the subacute phase after stroke.


Options:
A: Arm Label: enhanced upper-extremity program, EUEP; Type: EXPERIMENTAL; Interventions: Other: UFT | Arm Label: enhanced lower-extremity program,ELLP); Type: EXPERIMENTAL; Interventions: Other: LFT | Intervention Type: OTHER; Name: UFT; Assigned to Arm(s): enhanced upper-extremity program, EUEP | Intervention Type: OTHER; Name: LFT; Assigned to Arm(s): enhanced lower-extremity program,ELLP)
B: Arm Label: Long term follow up program; Type: EXPERIMENTAL; Interventions: Behavioral: Long term follow up by a coordinating physiotherapist | Arm Label: Standard care; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Standard care | Intervention Type: BEHAVIORAL; Name: Long term follow up by a coordinating physiotherapist; Assigned to Arm(s): Long term follow up program | Intervention Type: BEHAVIORAL; Name: Standard care; Assigned to Arm(s): Standard care
C: Arm Label: Sham; Type: PLACEBO_COMPARATOR; Interventions: Device: tDCS | Arm Label: tDCS; Type: EXPERIMENTAL; Interventions: Device: tDCS | Intervention Type: DEVICE; Name: tDCS; Assigned to Arm(s): Sham, tDCS
D: Arm Label: Upper limb motor function training + tDCS; Type: ACTIVE_COMPARATOR; Interventions: Device: transcranial direct current stimulation (tDCS) | Arm Label: upper limb motor function training + sham tDCS; Type: SHAM_COMPARATOR; Interventions: Device: transcranial direct current stimulation (tDCS) | Intervention Type: DEVICE; Name: transcranial direct current stimulation (tDCS); Assigned to Arm(s): Upper limb motor function training + tDCS, upper limb motor function training + sham tDCS

Answer: C