Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Multicentre, Randomised, Double-Blind, Placebo Controlled, Crossover Trial On The Efficacy Of A Mixture Of Three Bifidobacteria In Children With Abdominal Pain-Associated Functional Gastrointestinal Disorders
Brief Summary: Abdominal pain (AP)-associated functional gastrointestinal disorders (FGIDs), particularly Irritable Bowel Syndrome (IBS) and Functional Dyspepsia (FD), are common in pediatrics, and no safe and effective treatment is available. Although probiotics have shown promising results in adults, few studies have been published in children. The Bifidobacterium Infantis, Bifidobacterium Breve and Bifidobacterium Longum are the most important beneficial bacteria in children and represent 95% of the total bacterial population in the intestine of breastfed infant.

Objectives: 1) To evaluate the effect of oral administration of a mixture of Bifidobacteria on the improvement of frequency and intensity of AP in children with FD and IBS. 2) To evaluate the effect of oral administration of a mixture of Bifidobacteria on quality of life in children with FD and IBS.


Options:
A: Arm Label: Mixture of three Bifidobacteria; Type: ACTIVE_COMPARATOR; Interventions: Drug: Mixture of three Bifidobacteria | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Mixture of three Bifidobacteria | Intervention Type: DRUG; Name: Mixture of three Bifidobacteria; Assigned to Arm(s): Mixture of three Bifidobacteria, Placebo
B: Arm Label: Probiotics supplementation; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Probiotics | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: Probiotics; Assigned to Arm(s): Probiotics supplementation | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: Probiotic/abdominal pain; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Administration of L.reuteri in children with abdominal pain | Arm Label: Placebo/abdominal pain; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Administration of placebo in children with abdominal pain | Arm Label: Probiotic/constipation; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Administration of L.reuteri in children with constipation | Arm Label: Placebo/chronic constipation; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Administration of placebo in children with constipation | Intervention Type: DIETARY_SUPPLEMENT; Name: Administration of L.reuteri in children with abdominal pain; Assigned to Arm(s): Probiotic/abdominal pain | Intervention Type: DIETARY_SUPPLEMENT; Name: Administration of placebo in children with abdominal pain; Assigned to Arm(s): Placebo/abdominal pain | Intervention Type: DIETARY_SUPPLEMENT; Name: Administration of L.reuteri in children with constipation; Assigned to Arm(s): Probiotic/constipation | Intervention Type: DIETARY_SUPPLEMENT; Name: Administration of placebo in children with constipation; Assigned to Arm(s): Placebo/chronic constipation
D: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo | Arm Label: Probiotic; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Lactobacillus GG (probiotic ) | Intervention Type: DIETARY_SUPPLEMENT; Name: Lactobacillus GG (probiotic ); Assigned to Arm(s): Probiotic | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo; Assigned to Arm(s): Placebo

Answer: A