Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Family Integrated Care Model For The Neonatal Intensive Care Unit: A Cluster Randomised Controlled Trial
Brief Summary: In the highly technological environment of the modern neonatal intensive care unit (NICU), the infant is physically, psychologically and emotionally separated from its parents. Recognition that this impedes parent- infant interaction and is detrimental to the infant, led to the development of programs such as family centered care, kangaroo care and skin-to-skin care1-3. However, they are based on the common premise that only NICU professionals with special skills can provide care for the infant. Parents are relegated to a supportive role, and some have described themselves as voyeurs who are "allowed" to visit and hold their infants4. Many feel anxious and unprepared to care for their infants after discharge5.

In 1979, a shortage of NICU nurses in Estonia prompted Levin1,6 to implement a "humane" care model in which parents provided nursing care for the infant (except for administration of IV fluid and medication), while nurses provided teaching and guidance to parents. This resulted in 30% improvement in weight gain1,30% reduction in infections, 20% reduction in NICU length of stay, 50% reduction in nurse utilization and overall improved satisfaction among parents and staff \[personal communication, Levin,A.\]. Building on the Estonian experience, we have developed a new Family Integrated Care (FIC) model that is adapted for the NICU environment in North America. In a pilot study at Mount Sinai Hospital, Toronto 46 infants and their families were enrolled in the study. Preliminary results and feedback from parents and healthcare providers (HCP) show that the FIC model is both feasible and safe, and may lead to improved outcomes including improved weight gain(paper submitted for publication). This study is a cluster randomized controlled trial in 16 tertiary level NICUs, to evaluate the efficacy of the FIC model in Canada.


Options:
A: Inclusion Criteria:

* \< 33 weeks gestational age at birth;
* On no respiratory support or low level respiratory support (i.e., oxygen by cannula or mask, or continuous positive airway pressure (CPAP);
* A primary caregiver parent who is willing and able to commit to spending at least 8 hours per day with her/his infant between the hours of 0700 and 2000;
* Parental consent.

Exclusion Criteria:

* Palliative care;
* Major life threatening congenital anomaly;
* Critical illness (unlikely to survive);
* On high level of respiratory support (mechanical ventilator, high frequency oscillatory or jet ventilation, extra-corporeal membrane oxygenation)
* Parental request for early transfer to another hospital;
* Parental inability to participate (e.g., health, social or language issues that might inhibit their ability to communicate with the healthcare team).
B: Inclusion Criteria:

* Pregnant women
* Age \> 18 years
* 1st consultation before the 26th week of amenorrhea
* Recipient of free health care (Couverture Maladie Universelle, Couverture Maladie Universelle-Complémentaire)
* Who have provided written informed consent to take part in the study

Exclusion Criteria:

* Persons without national health insurance cover
* Persons unable to understand the information on the study, despite the help of a translator or a person of trust if necessary
* Persons under guardianship
C: Inclusion Criteria:

* Children between 0 - 23 months of age visiting the EPI center for BCG/OPV-0 or Pentavalent-1/Polio-1/PCV-1 or Pentavalent-2/Polio-2/PCV-2 vaccination.
* Children permanently residing within Korangi Town, Karachi and planto remain there for the next three years.
* Caregiver accompanying the child can provide a valid mobile phone number at the time of enrolment

Exclusion Criteria:

* Children visiting the EPI center for Pentavalent-2 or Measles-1 or Measles 2
* Children born out of multiple births i.e twins or triplets
* Children not residing or planning to move out of Korangi in the next three years
* Children accompanied by caregivers unable to provide a phone number
D: Inclusion Criteria:

The eligible population includes patients less than 80 years of age enrolled in primary care clinics at the study sites that meet the following additional inclusion criteria:

* No active prescription for a thiazide diuretic (or a medication that combines a thiazide and another agent (e.g., hydrochlorothiazide and triamterene)
* Prior diagnosis of hypertension, as documented in VA outpatient administrative files
* Two or more visits to a primary care clinic in the prior 12 months;
* Blood pressure above treatment goal at the two most recent VA outpatient clinic visits Above goal is defined as a systolic pressure \>140 mmHg or diastolic pressure \>90 mmHg. For diabetics above goal is defined as systolic pressure \>130 mmHg or diastolic pressure \>80 mmHg
* Blood pressure at goal (as defined above) during one of the last two outpatient clinic visits, but the patient is receiving a prescription for a calcium channel blocker (CCB)

Exclusion Criteria:

Patients meeting the above inclusion criteria will be excluded for the following reasons:

* Documented allergy to thiazides or to sulfa agents
* Previously documented intolerance or adverse drug reaction to thiazide diuretics
* Active prescription for a loop diuretic agent (e.g. furosemide)
* Renal insufficiency, defined by a glomerular filtration rate less than 30 ml/min
* No serum creatinine in the past year (to permit calculation of a creatinine clearance)
* Prior history of hypokalemia or serum potassium less than 3.5 meq/l in the prior year
* Diagnosis of gout or active prescription for allopurinol
* Congestive heart failure (CHF) due to systolic dysfunction with a documented left ventricular ejection fraction \< 35% by echocardiography, nuclear medicine study, or ventriculography
* Residence in a long-term care facility
* No telephone for follow-up calls
* Life-expectancy \< 6 months
* Inability to give informed consent or impaired cognitive function (defined as \> 4 errors on the 10-item Pfeiffer Portable Mental Status Questionnaire82, administered during study intake)

Answer: A