Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Phase 2 Study of Oral Probiotics Reduce the Incidence and Severity of Necrotizing Enterocolitis for Very Low Birth Weight Infants -Multi-Center Randomized Control Trial
Brief Summary: We investigate the efficacy of probiotics in reducing the incidence and severity of necrotizing enterocolitis (NEC) for very low birth weight (VLBW) infants.A prospective, masked, multi-center randomized control trial will be conducted level III neonatal center to evaluate the beneficial effects of probiotics for NEC among VLBW (\<1500 g) infants. VLBW infants who start to feed enterally are eligible and are randomized into 2 groups after parental informed consents were obtained. Infants in the study group are fed with Infloran (Lactobacillus acidophilus and Bifidobacterium bifidus) with breast or formula milk twice daily for 6 weeks. Infants in the control group are fed with breast or formula milk alone. The clinicians caring for the infants are blinded to the group assignment. The primary outcome measurement is death or NEC (≧stage 2).


Options:
A: Arm Label: Probiotics; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Probiotics | Arm Label: Probiotics + Dietary counseling; Type: EXPERIMENTAL; Interventions: Behavioral: Dietary counselling and probiotics | Arm Label: Dietary counseling + placebo; Type: EXPERIMENTAL; Interventions: Behavioral: Dietary counselling and placebo | Arm Label: Prebiotics; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Prebiotics | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo capsules | Arm Label: Control; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: Dietary counselling and placebo; Assigned to Arm(s): Dietary counseling + placebo | Intervention Type: BEHAVIORAL; Name: Dietary counselling and probiotics; Assigned to Arm(s): Probiotics + Dietary counseling | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo capsules; Assigned to Arm(s): Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: Probiotics; Assigned to Arm(s): Probiotics | Intervention Type: DIETARY_SUPPLEMENT; Name: Prebiotics; Assigned to Arm(s): Prebiotics
B: Arm Label: Bifidobacterium lactis; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Bifidobacterium lactis plus İnülin, Other: Maltodextrin, Dietary Supplement: İnulin | Arm Label: İnulin; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Bifidobacterium lactis, Dietary Supplement: Bifidobacterium lactis plus İnülin, Other: Maltodextrin | Arm Label: Maltodextrin; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Bifidobacterium lactis, Dietary Supplement: Bifidobacterium lactis plus İnülin, Dietary Supplement: İnulin | Arm Label: Bifidobacterium lactis plus İnülin; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Bifidobacterium lactis, Other: Maltodextrin, Dietary Supplement: İnulin | Intervention Type: DIETARY_SUPPLEMENT; Name: Bifidobacterium lactis; Assigned to Arm(s): Bifidobacterium lactis plus İnülin, Maltodextrin, İnulin | Intervention Type: DIETARY_SUPPLEMENT; Name: Bifidobacterium lactis plus İnülin; Assigned to Arm(s): Bifidobacterium lactis, Maltodextrin, İnulin | Intervention Type: OTHER; Name: Maltodextrin; Assigned to Arm(s): Bifidobacterium lactis, Bifidobacterium lactis plus İnülin, İnulin | Intervention Type: DIETARY_SUPPLEMENT; Name: İnulin; Assigned to Arm(s): Bifidobacterium lactis, Bifidobacterium lactis plus İnülin, Maltodextrin
C: Arm Label: 1; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Lactobacillus reuteri | Intervention Type: DIETARY_SUPPLEMENT; Name: Lactobacillus reuteri; Assigned to Arm(s): 2 | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo; Assigned to Arm(s): 1
D: Arm Label: 2; Type: EXPERIMENTAL; Interventions: Dietary Supplement: infloran | Intervention Type: DIETARY_SUPPLEMENT; Name: infloran; Assigned to Arm(s): 2 | Intervention Type: DIETARY_SUPPLEMENT; Name: infloran; Assigned to Arm(s): 2

Answer: D