Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Prospective, Randomized Multicenter, Open-label Comparison of Preoperative Trastuzumab Emtansine (T-DM1) With or Without Standard Endocrine Therapy vs. Trastuzumab With Standard Endocrine Therapy Given for Twelve Weeks in Patients With Operable HER2+/HR+ Breast Cancer Within the ADAPT Protocol.
Brief Summary: Trial to optimize neoadjuvant therapy for HER overexpression and co-expressing of hormone receptors(ER and/or PR) breast cancer (HEr2+/HR+).

A new high potential trastuzumab conjugate T-DM1(trastuzumab was linked with the cytotoxic agent mertansine DM1)was tested with endocrine therapy and without against a standard arm with trastuzumab and endocrine therapy.


Options:
A: Arm Label: Arm I (paclitaxel, doxorubicin, cyclophosphamide); Type: ACTIVE_COMPARATOR; Interventions: Drug: Cyclophosphamide, Drug: Doxorubicin Hydrochloride, Other: Laboratory Biomarker Analysis, Drug: Paclitaxel | Arm Label: Arm II (paclitaxel, ddAC, bevacizumab); Type: EXPERIMENTAL; Interventions: Biological: Bevacizumab, Drug: Cyclophosphamide, Drug: Doxorubicin Hydrochloride, Other: Laboratory Biomarker Analysis, Drug: Paclitaxel | Arm Label: Arm III (paclitaxel, ddAC, carboplatin); Type: EXPERIMENTAL; Interventions: Drug: Carboplatin, Drug: Cyclophosphamide, Drug: Doxorubicin Hydrochloride, Other: Laboratory Biomarker Analysis, Drug: Paclitaxel | Arm Label: Arm IV (paclitaxel, ddAC, bevacizumab, carboplatin); Type: EXPERIMENTAL; Interventions: Biological: Bevacizumab, Drug: Carboplatin, Drug: Cyclophosphamide, Drug: Doxorubicin Hydrochloride, Other: Laboratory Biomarker Analysis, Drug: Paclitaxel | Intervention Type: BIOLOGICAL; Name: Bevacizumab; Assigned to Arm(s): Arm II (paclitaxel, ddAC, bevacizumab), Arm IV (paclitaxel, ddAC, bevacizumab, carboplatin) | Intervention Type: DRUG; Name: Carboplatin; Assigned to Arm(s): Arm III (paclitaxel, ddAC, carboplatin), Arm IV (paclitaxel, ddAC, bevacizumab, carboplatin) | Intervention Type: DRUG; Name: Cyclophosphamide; Assigned to Arm(s): Arm I (paclitaxel, doxorubicin, cyclophosphamide), Arm II (paclitaxel, ddAC, bevacizumab), Arm III (paclitaxel, ddAC, carboplatin), Arm IV (paclitaxel, ddAC, bevacizumab, carboplatin) | Intervention Type: DRUG; Name: Doxorubicin Hydrochloride; Assigned to Arm(s): Arm I (paclitaxel, doxorubicin, cyclophosphamide), Arm II (paclitaxel, ddAC, bevacizumab), Arm III (paclitaxel, ddAC, carboplatin), Arm IV (paclitaxel, ddAC, bevacizumab, carboplatin) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Arm I (paclitaxel, doxorubicin, cyclophosphamide), Arm II (paclitaxel, ddAC, bevacizumab), Arm III (paclitaxel, ddAC, carboplatin), Arm IV (paclitaxel, ddAC, bevacizumab, carboplatin) | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): Arm I (paclitaxel, doxorubicin, cyclophosphamide), Arm II (paclitaxel, ddAC, bevacizumab), Arm III (paclitaxel, ddAC, carboplatin), Arm IV (paclitaxel, ddAC, bevacizumab, carboplatin)
B: Arm Label: T-DM1; Type: EXPERIMENTAL; Interventions: Drug: T-DM1 | Arm Label: T-DM1 + endocrine therapy; Type: EXPERIMENTAL; Interventions: Drug: T-DM1 | Arm Label: Trastuzumab + endocrine therapy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Trastuzumab | Intervention Type: DRUG; Name: T-DM1; Assigned to Arm(s): T-DM1, T-DM1 + endocrine therapy | Intervention Type: DRUG; Name: Trastuzumab; Assigned to Arm(s): Trastuzumab + endocrine therapy
C: Arm Label: EC-T; Type: ACTIVE_COMPARATOR; Interventions: Drug: EC-T | Arm Label: TP; Type: EXPERIMENTAL; Interventions: Drug: TP | Intervention Type: DRUG; Name: EC-T; Assigned to Arm(s): EC-T | Intervention Type: DRUG; Name: TP; Assigned to Arm(s): TP
D: Arm Label: Arm A; Type: EXPERIMENTAL; Interventions: Drug: nab-Paclitaxel, Drug: Gemcitabine | Arm Label: Arm B; Type: EXPERIMENTAL; Interventions: Drug: nab-Paclitaxel, Drug: Carboplatin | Intervention Type: DRUG; Name: nab-Paclitaxel; Assigned to Arm(s): Arm A, Arm B | Intervention Type: DRUG; Name: Gemcitabine; Assigned to Arm(s): Arm A | Intervention Type: DRUG; Name: Carboplatin; Assigned to Arm(s): Arm B

Answer: B