Please select the eligibility criteria that correspond to the clinical trial below.
Title: Effect of Intensive Cognitive Rehabilitation in Subacute Stroke Patient
Brief Summary: Early stroke rehabilitation is known to be an effective and essential therapy in gaining functional independence and preventing complications. However, there was no consensus of proper amount of cognitive rehabilitation in stroke patients. In this study, the investigators assess the effects of the intensive cognitive rehabilitation during subacute phase to improve cognitive function at 6 months after onset in patients with first-ever strokes.


Options:
A: Inclusion criteria

1. Diagnosis of ischemic stroke in the right middle cerebral artery or right intra-cerebral hemorrhagic stroke, confirmed by brain CT and / or brain MRI;
2. Diagnosis of LHSN with a specific test (asymmetry score on Bells cancellation test \> 3\]);
3. Intra-hospital rehabilitation setting (ordinary hospitalization or DH) or outpatient setting;
4. Age between 18 and 80 years;
5. Time between stroke onset and study recruitment three weeks to three months;
6. Availability to provide informed consent to participation.

Exclusion criteria

1. Clinical instability at recruitment (for example, fever, acute internist conditions, etc.);
2. History of epilepsy and / or occurrence in the acute phase of at least one seizure crisis
3. Presence of intracranial metallic implants;
4. Presence of devices, which could be altered by r-TMS, such as pacemakers, ventricular-peritoneal derivations, Baclofen pump;
5. Absence of a bone operculum following a neurosurgical operation of decompressive craniotomy;
6. Presence of behavioral disturbances with inversion of the sleep-wake rhythm
7. Mono- or bilateral occipital lesions documented on CT and / or history of cortical blindness or visual agnosia;
8. Concomitant psychiatric disorders and / or history of substance abuse;
9. State of pregnancy
10. Inability to execute the following simple order: "Take the pen instead of the key and put it on the sheet"
11. Severe acoustic deficit not corrected by the use of a hearing aid
12. Severe reduction of the visus despite the use of eyeglasses
13. Positive anamnesis of previous cognitive decline
B: Inclusion Criteria:

* First stroke patients with right brain damage
* Right-handed
* Preserved Italian language comprehension to provide informed consensus
* Clinical signs of spatial neglect (diagnosis by BIT)

Exclusion Criteria:

* Prior history of psychiatric or neurological disease
* Substance abuse
* Inability to sustain the experimental trainings
C: Inclusion Criteria:

* Acute first-ever stroke
* Korean Mini-Mental State Examination: 11\~24 at 7 days after stroke onset

Exclusion Criteria:

* Transient ischemic stroke
D: Inclusion Criteria:

* Ischemic or hemorrhagic stroke 3 months post stroke.
* Fugl-Meyer Upper Extremity (FMA-Upper Extremity) score between 20-56/60
* Inducible motor evoked potential (MEP) of the abductor pollicis brevis (APB) on the paretic stimulation (TMS)
* Demonstrate the presence of unilateral neglect (Virtual Reality Lateralized Attention Test score \<18)

Exclusion Criteria:

* History of cortical hemorrhagic stroke
* Presence of any MRI, TMS, tDCS risk factors including:

  * history of seizures
  * history of brain tumor
  * hardware in skull or spine (e.g. coils, clips)
  * implantable medical device (e.g. pacemaker)
  * metal in body (not compatible with MRI)
  * pregnancy
* Severe spasticity (Modified Ashworth Scale score 3)
* Severe aphasia or cognitive impairment limiting participants' comprehension (National Institutes of Health Stroke Scale Level of Consciousness Commands Item score 1 or Best Language Item score 2)
* Unable to travel to UE Motor Function Laboratory at the Center for Rehabilitation Research in Neurological Conditions (a collaborative, MOU approved, research center Ralph H. Johnson VA Medical Center and the Medical University of South Carolina) for the study

Answer: C