Please select the eligibility criteria that correspond to the clinical trial below.
Title: Investigating the Safety of Morphine and Ibuprofen in Children Post-adenotonsillectomy for Obstructive Sleep Apnea
Brief Summary: Every year thousands of young children with obstructive sleep apnea undergo surgery which requires them to be prescribed pain medication. The current standard in North America is administration of opioids, mainly codeine or morphine; however in many areas of the world including Canada, nonsteroidal anti-inflammatory medications such as ibuprofen are used. Some North American surgeons are uncertain regarding the potential of ibuprofen to increase bleeding following surgery. The results of research studies have been inconclusive overall. Due to recent codeine fatalities in children following adenotonsillectomy, codeine has been removed from the formulary at many Pediatric institutions. Some surgeons have begun to use oral morphine as an alternate to codeine, which necessitates the need to find safe alternative analgesics in this treatment group.

The primary objectives of this study is to assess the safety(1) and efficacy (2) of morphine and ibuprofen in children with sleep apnea.

An interim analysis will be conducted after recruitment of 70 patients, to monitor both safety and efficacy


Options:
A: Inclusion Criteria:

* Healthy, ambulatory, male or female volunteers 16-40 years of age;
* Body mass index 18.0 to 30.0 kg/m\^2 inclusive;
* Scheduled to undergo surgical removal of at least 2 mandibular partial or full bony impacted third molars. Up to two maxillary third molars may be removed regardless of impaction level. Supernumerary teeth present may also be removed at the discretion of the oral surgeon;
* Mandibular molars must demonstrate modified Demirjian root classification stage D, E, F, G or H;

Exclusion Criteria:

* History of hypersensitivity to naproxen sodium, ibuprofen, nonsteroidal anti-inflammatory drugs (NSAIDS), aspirin, similar pharmacological agents, local anesthetics, rescue medication or components of the investigational products;
* Evidence or history of clinically significant (in the judgment of the investigator) hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic diseases, or malignancies within the last 5 years;
* Relevant concomitant disease such as asthma (exercise induced asthma is permitted)
B: Inclusion Criteria:

* Age\<=18 years
* Undergoing ERCP (defined as cannulation of the major or minor papilla) for any indication

Exclusion Criteria:

* Age\>18
* Pancreatitis within the 72 hours preceding ERCP
* Allergy or hypersensitivity to Aspirin or NSAID medications
* Pregnancy or breastfeeding mother
* Cr \>1.4
* Gastrointestinal hemorrhage in preceding 72 hours
* Heart disease reliant upon a patient ductus arteriosis
* History of sickle cell disease
C: Inclusion Criteria:

* diagnosed with OSAS,
* scheduled for tonsillectomy plus/minus adenoid removal at MUMC,
* between the ages of 1-10years

Exclusion Criteria:

* contraindications to analgesia,
* asthma,
* has had previous adenotonsillectomy, or
* any craniofacial,
* neuromuscular or cardiac conditions
D: Inclusion Criteria:

* scheduled to undergo laparoscopic inguinal hernia surgery
* American Society of Anesthesiologists physical status classification 1 or 2
* Children aged 6 months to 6 years

Exclusion Criteria:

* history of Gastrointestinal bleeding
* history or laboratory finding of suspected renal or hepatic dysfunction
* bronchial asthma
* bleeding disorder
* hypersensitivity to NSAID or propacetamol
* disagreement of investigation
* The researcher determines that participation is inappropriate due to other reasons.

Answer: C