Please select the eligibility criteria that correspond to the clinical trial below.
Title: Effect of the Prescription of 10,000 Steps a Day Using a Pedometer Via Mobile APP, Through a Goal Setting System, in the Body Composition of Overweight Adults: a 6-Month Randomized Weight Loss and mHealth Trial.
Brief Summary: This study aimed the effect of the Accupedo pedometer smartphone app intervention, with goal setting of walking prescription of 10,000 steps per day, in overweight adults.


Options:
A: Inclusion Criteria:

1. Age: More than 20 years of age and under 70 years of age.
2. BMI ≥ 25kg/m2
3. Patients with metabolic syndrome (who have more than three of following 5 components of metabolic syndrome) and who are able to receive outpatient treatment.

   A. Abdominal obesity: Waist circumference≥90cm(Male), 85cm(Female) B. Patients whose blood pressure ≥130/85mmHg(systolic blood pressure over 130 or, diastolic blood pressure over 85) or patients who are taking blood pressure medication.

   C. Fasting Blood Glucose (FPG)≥ 100mg/dl. D. Patients whose triglyceride ≥150 mg/dl or patients who are taking fibrate. E. High-density lipoprotein cholesterol (HDL) \< 40 mg/dl (Male), 50 mg/dl(Female)
4. Patients who are able to understand the purpose of this trial and to read and write.
5. Patients who are able to use U-healthcare Smartphone for this trial.
6. Patients who participate voluntarily and sign the informed consent.

Exclusion Criteria:

1. Type I diabetes mellitus patients and type II diabetes mellitus patients requiring insulin therapy.
2. Patients currently being hospitalized or planning to hospitalize during the study period.
3. Patients were diagnosed with myocardial infarction or stroke within 1 year
4. End Stage Renal Disease patients requiring renal replacement therapy, Serum creatinine level is greater than 1.5 times the upper limit of normal.
5. Females who are pregnant
6. Hepatic failure (severe hepatic dysfunction). Liver Function Test (AST or ALT) is greater than 3 times the upper limit of normal.
7. Uncontrolled chronic lung disease.
8. Patients with known gallstone.
9. Patients who have cognitive disorder or psychiatric problems.
10. Patients who are taking anti-obesity medications such as Reductil, Xenical, etc., or patients are planning to receive the medications.
11. Patients who are taking Synthroid, diabetes medications or psychiatric medications which may affect on body weight.
12. Any clinically significant medical condition including neurologic disease, gastrointestinal disease or malignant tumor, etc., which may affect the test results, or any other medical condition which in the opinion of the investigator makes the patients unsuitable for participation in the trial.
13. Patients who have participated in other clinical trial (except for the observational study) within 12 weeks prior to screening visit.
B: Inclusion Criteria:

* Having a IMC \>25,
* Being sedentary and
* Have not been submitted to a restrictive diet in the 6 months preceding this study.

Exclusion Criteria:

* Suffered from type 2 diabetes or renal conditions
* Being pregnancy or attempt at pregnancy,
* Being in a maternal lactation period,
* Being underage
* Undergoing antidepressant pharmacological treatment
C: Inclusion Criteria:

* Age 18 to 35 years
* Intending to be available for a 24 month intervention
* Full-time student enrollment at one of the designated San Diego college or university campuses: UCSD, SDSU, and CSU San Marcos
* Facebook user or willingness to begin using Facebook
* Owns personal computer
* Owns mobile phone and uses text messaging
* Willing to attend required research measurement visits in San Diego over the 2 year RCT
* Participants must meet overweight and obesity criteria: 25 \< BMI \<35 kg/m2
* English-speaking
* Able to ambulate unassisted

Exclusion Criteria:

* Those unable to provide informed consent
* Those with a BMI of \<25 kg/m2 or \>35 kg/m2
* Those who have a household member on the study staff
* Those with any comorbidities of obesity who require immediate sub-specialist referral including pseudo-tumor cerebri, sleep apnea/hypoventilation syndrome, orthopedic problems, and meeting American Diabetes Association criteria for diabetes
* Cardiovascular event within the last 6 months
* Systolic BP at screening of \>160 mmHg OR diastolic BP \> 100 mmHg
* Current treatment for malignancy other than non-melanoma skin cancer
* Psychiatric or medical condition that prohibit compliance with study protocol, prescribed dietary changes and/or moderate physical activity
* Current treatment for eating disorder
* Taking medications that alter weight
* Regular use of systemic steroids
* Currently pregnant, gave birth within the last 6 months, currently lactating or breastfeeding within the last 3 months or intending to get pregnant over the next two years
* Enrolled in or planning to enroll in another weight loss program
* Past or planned (within the next 24 months) weight loss surgery
* Current participation in a commercial weight loss program
* Investigator discretion
* Non-English speaking
* Not able to ambulate unassisted
D: Inclusion Criteria:

* Body mass index (BMI) is \> 25 kg/m2 and \< 35 kg/m2.
* Willing to use cell phones provided by the PBRC or personal cell phones to take pictures of foods during the study and to receive messages from study personnel.
* Willing to wear an activity monitor on your shoe and to use the internet to send information as frequently as once daily.
* Willing to weigh on a scale provided by the PBRC as frequently as once per day
* Willing to accept random assignment to either the e-Health (RIDE group) or control group.
* Weight stable, defined as no greater than 4.4 lbs. (2 kg) weight change over the previous 60 days.

Exclusion Criteria:

* Diagnosed with a chronic disease that affects body weight, appetite, or metabolism, namely diabetes, cardiovascular disease, cancer, and thyroid diseases or conditions.
* Currently in a weight loss program.
* Unable to engage in moderate intensity exercise.
* Unable to diet or exercise due to your medical history or current health status.
* Current use of prescriptions or over-the-counter medications or herbal products that affect appetite, body weight, or metabolism (e.g., weight loss medications such as sibutramine, antipsychotic medications such as olanzapine, ephedrine, and diuretics).
* Diagnosed with uncontrolled hypertension (high blood pressure), defined as systolic blood pressure \>159 mmHg \& diastolic blood pressure \>99 mmHg.
* For females, current pregnancy, or plans to become pregnant in the duration of the study.

Answer: B