Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Postoperative Ibuprofen and the Risk of Bleeding After Tonsillectomy With or Without Adenoidectomy
Brief Summary: Tonsillectomy (the surgical removal of the tonsils) is a commonly performed surgery in children. One risk of tonsillectomy is postoperative bleeding, and this can be more dangerous in children because their blood volume is lower than adults. Ibuprofen, a nonsteroidal anti-inflammatory medication (NSAID), is an effective pain medication. Recent guidelines, published by the American Academy of Otolaryngology, advocated use of ibuprofen after tonsillectomy. However, NSAIDs are associated with altered platelet function and a theoretical increased risk of bleeding after surgery. The investigators would like to explore the effect that ibuprofen has on postoperative bleeding, as well as validate previous studies demonstrating it is an effective pain medication after tonsillectomy.


Options:
A: Arm Label: Maxigesic IV; Type: EXPERIMENTAL; Interventions: Drug: Maxigesic IV | Arm Label: IV Acetaminophen; Type: ACTIVE_COMPARATOR; Interventions: Drug: IV Acetaminophen | Arm Label: IV Ibuprofen; Type: ACTIVE_COMPARATOR; Interventions: Drug: IV Ibuprofen | Arm Label: Placebo IV; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo IV | Intervention Type: DRUG; Name: Maxigesic IV; Assigned to Arm(s): Maxigesic IV | Intervention Type: DRUG; Name: IV Acetaminophen; Assigned to Arm(s): IV Acetaminophen | Intervention Type: DRUG; Name: IV Ibuprofen; Assigned to Arm(s): IV Ibuprofen | Intervention Type: DRUG; Name: Placebo IV; Assigned to Arm(s): Placebo IV
B: Arm Label: Ibuprofen/acetaminophen (lower dose); Type: EXPERIMENTAL; Interventions: Drug: Ibuprofen/acetaminophen | Arm Label: Ibuprofen/acetaminophen (middle dose); Type: EXPERIMENTAL; Interventions: Drug: Ibuprofen/acetaminophen | Arm Label: Ibuprofen/acetaminophen (high dose); Type: EXPERIMENTAL; Interventions: Drug: Ibuprofen/acetaminophen | Arm Label: Ibuprofen; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ibuprofen | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Ibuprofen/acetaminophen; Assigned to Arm(s): Ibuprofen/acetaminophen (lower dose) | Intervention Type: DRUG; Name: Ibuprofen/acetaminophen; Assigned to Arm(s): Ibuprofen/acetaminophen (middle dose) | Intervention Type: DRUG; Name: Ibuprofen/acetaminophen; Assigned to Arm(s): Ibuprofen/acetaminophen (high dose) | Intervention Type: DRUG; Name: Ibuprofen; Assigned to Arm(s): Ibuprofen | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: Treatment with Ibuprofen; Type: EXPERIMENTAL; Interventions: Drug: Ibuprofen | Arm Label: Treatment with Acetaminophen; Type: ACTIVE_COMPARATOR; Interventions: Drug: Acetaminophen | Intervention Type: DRUG; Name: Ibuprofen; Assigned to Arm(s): Treatment with Ibuprofen | Intervention Type: DRUG; Name: Acetaminophen; Assigned to Arm(s): Treatment with Acetaminophen
D: Arm Label: Paracetamol/codeine Group A; Type: ACTIVE_COMPARATOR; Interventions: Drug: paracetamol 500 mg plus codeine 30 mg preoperative administration | Arm Label: Ibuprofen Group B; Type: ACTIVE_COMPARATOR; Interventions: Drug: ibuprofen 400 mg preoperative administration | Arm Label: Placebo Group C; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo oral tablet preoperative administration | Intervention Type: DRUG; Name: paracetamol 500 mg plus codeine 30 mg preoperative administration; Assigned to Arm(s): Paracetamol/codeine Group A | Intervention Type: DRUG; Name: ibuprofen 400 mg preoperative administration; Assigned to Arm(s): Ibuprofen Group B | Intervention Type: DRUG; Name: Placebo oral tablet preoperative administration; Assigned to Arm(s): Placebo Group C

Answer: C