Please select the eligibility criteria that correspond to the clinical trial below.
Title: Mifepristone and Misoprostol Versus Misoprostol Alone for Uterine Evacuation After Early Pregnancy Failure: a Randomized Double Blind Placebo-controlled Comparison (Triple M Trial)
Brief Summary: This study aims to compare whether a combination of two drugs (Mifepristone and misoprostol) are superior compared to using only one of these drugs (Misoprostol) as medical treatment for a miscarriage. Women in whom early pregnancy failure, 6-14 weeks postmenstrual, is ultrasonographically confirmed qualify for this study.

It is expected that the combination of Mifepristone and Misoprostol is more effective in reaching complete evacuation, and therefore can prevent more invasive treatment such as curettage.


Options:
A: Inclusion Criteria:

* no contraindications to misoprostol
* uterine size was not larger than 12 weeks
* there were no signs of severe infection
* haemodynamically stable
* in general good health
* willing to provide contact information

Exclusion Criteria:

* an IUD in place
* ectopic pregnancy
* aged below 18 years and had no accompanying adult to provide informed consent
B: Inclusion Criteria:

* Major, under 45 years with intrauterine trophoblastic retention after incomplete miscarriage in the first quarter (termination of pregnancy \< 14 WA),
* With desire of pregnancy ;
* Intrauterine trophoblastic retention diagnosed by transvaginal pelvic ultrasound finding a intrauterine heterogeneous image or intrauterine gestational sac more than 15 mm in thickness, complicated or not of endometritis ;
* Decision to surgical management of incomplete miscarriage by the health care team ;
* Patient beneficiary or affiliated to a health insurance
* Informed and signed consent

Exclusion Criteria:

Will not be included in the protocol patients :

* having a uterine malformation known ;
* having received surgical treatment for the current intrauterine retention ;
* with intrauterine retention diagnosed by transvaginal pelvic ultrasound of more than 50 mm in thickness ;
* requiring a haemostatic act in urgency for heavy vaginal bleeding (miscarriage haemorrhage) ;
* bearer of intrauterine device ;
* having an evolutive pregnancy;
* having an ectopic pregnancy;
* having a trophoblastic retention following a voluntary abortion ;
* having a pregnancy achieved by medically assisted procreation
C: Inclusion Criteria:

Early pregnancy failure, 6-14 weeks postmenstrual with

* a crown-rump length ≥ 6mm and no cardiac activity OR
* a crown-rump length \<6mm and no fetal growth at least one week later OR
* a gestational sac with absent embryonic pole for at least one week.

  * At least one week after diagnosis OR a discrepancy of at least one week between crown-rump length and calendar gestational age
  * Intra-uterine pregnancy
  * Women aged above 16 years
  * Hemodynamic stable patient
  * No signs of infection
  * No signs of incomplete abortion
  * No contraindications for mifepristone or misoprostol

Exclusion Criteria:

* Patient does not meet inclusion criteria, discovered after randomization
* Inability to give informed consent
* Known clotting disorder or use of anticoagulants
* Known risk factors for, or presence of, a cardiovascular disease
* Language barrier
D: Inclusion Criteria:

* 14 and 24 weeks of gestation
* Both nulliparous and multiparous women
* An unfavorable cervix (Bishop's score less than 8)

Exclusion Criteria:

* Known contraindications to the use of prostaglandins (e.g. asthma)
* Previous uterine scar (previous cesarean or myomectomy where the endometrial cavity was entered)

Answer: C