Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase 2 Multicenter, Randomized, Double-Blind, Placebo-Controlled, 3-Period Crossover Study to Evaluate the Efficacy and Safety of Recombinant Human C1 Inhibitor in the Prophylaxis of Angioedema Attacks in Patients With Hereditary Angioedema (HAE)
Brief Summary: Primary Objective:

To evaluate the efficacy of recombinant human C1 inhibitor (rhC1INH) in the prophylaxis of angioedema attacks in patients with HAE

Secondary Objective:

To evaluate the safety and immunogenicity of recombinant human C1 inhibitor (rhC1INH) in the prophylaxis of angioedema attacks in patients with HAE


Options:
A: Arm Label: rhC1INH twice weekly; Type: EXPERIMENTAL; Interventions: Biological: Recombinant human C1 inhibitor | Arm Label: rhC1INH once weekly; Type: EXPERIMENTAL; Interventions: Biological: Recombinant human C1 inhibitor | Arm Label: Placebo (Saline) twice weekly; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Intervention Type: BIOLOGICAL; Name: Recombinant human C1 inhibitor; Assigned to Arm(s): rhC1INH once weekly, rhC1INH twice weekly | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo (Saline) twice weekly
B: Arm Label: Experimental/Placebo; Type: EXPERIMENTAL; Interventions: Drug: C1 esterase inhibitor [human] liquid, Drug: Placebo | Arm Label: Placebo/Experimental; Type: EXPERIMENTAL; Interventions: Drug: C1 esterase inhibitor [human] liquid, Drug: Placebo | Arm Label: Experimental/ Experimental; Type: EXPERIMENTAL; Interventions: Drug: C1 esterase inhibitor [human] liquid | Intervention Type: DRUG; Name: C1 esterase inhibitor [human] liquid; Assigned to Arm(s): Experimental/ Experimental, Experimental/Placebo, Placebo/Experimental | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Experimental/Placebo, Placebo/Experimental
C: Arm Label: BCX7353 110mg once daily; Type: EXPERIMENTAL; Interventions: Drug: BCX7353 capsules | Arm Label: BCX7353 150mg once daily; Type: EXPERIMENTAL; Interventions: Drug: BCX7353 capsules | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo oral capsule | Intervention Type: DRUG; Name: BCX7353 capsules; Assigned to Arm(s): BCX7353 110mg once daily | Intervention Type: DRUG; Name: BCX7353 capsules; Assigned to Arm(s): BCX7353 150mg once daily | Intervention Type: DRUG; Name: Placebo oral capsule; Assigned to Arm(s): Placebo
D: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: CSL312 (low); Type: ACTIVE_COMPARATOR; Interventions: Biological: Factor XIIa antagonist monoclonal antibody | Arm Label: CSL312 (med); Type: ACTIVE_COMPARATOR; Interventions: Biological: Factor XIIa antagonist monoclonal antibody | Arm Label: CSL312 (high); Type: ACTIVE_COMPARATOR; Interventions: Biological: Factor XIIa antagonist monoclonal antibody | Arm Label: CSL312 (med/high); Type: ACTIVE_COMPARATOR; Interventions: Biological: Factor XIIa antagonist monoclonal antibody | Intervention Type: BIOLOGICAL; Name: Factor XIIa antagonist monoclonal antibody; Assigned to Arm(s): CSL312 (high), CSL312 (low), CSL312 (med), CSL312 (med/high) | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo

Answer: A