Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Effect of Combination Ezetimibe and High-Dose Simvastatin vs Simvastatin Alone on the Atherosclerotic Process in Subjects With Heterozygous Familial Hypercholesterolemia (The ENHANCE Trial)
Brief Summary: The purpose of the study is to determine whether ezetimibe plus simvastatin will be more effective than simvastatin alone in preventing progression of atherosclerosis of the inner layer of the carotid artery.


Options:
A: Arm Label: Atorvastatin + Evacetrapib; Type: EXPERIMENTAL; Interventions: Drug: Evacetrapib, Drug: Atorvastatin, Drug: Placebo | Arm Label: Atorvastatin 80 mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Atorvastatin, Drug: Placebo | Arm Label: Atorvastatin + Ezetimibe; Type: ACTIVE_COMPARATOR; Interventions: Drug: Atorvastatin, Drug: Ezetimibe, Drug: Placebo | Arm Label: Atorvastatin 40 mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Atorvastatin, Drug: Placebo | Intervention Type: DRUG; Name: Evacetrapib; Assigned to Arm(s): Atorvastatin + Evacetrapib | Intervention Type: DRUG; Name: Atorvastatin; Assigned to Arm(s): Atorvastatin + Evacetrapib, Atorvastatin + Ezetimibe, Atorvastatin 40 mg, Atorvastatin 80 mg | Intervention Type: DRUG; Name: Ezetimibe; Assigned to Arm(s): Atorvastatin + Ezetimibe | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Atorvastatin + Evacetrapib, Atorvastatin + Ezetimibe, Atorvastatin 40 mg, Atorvastatin 80 mg
B: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: Ezetimibe, Drug: Niaspan, Drug: Statin therapy, Behavioral: Standard care, Drug: Aspirin, Drug: Clopidogrel, Procedure: Percutaneous transluminal angioplasty (PTA) | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Drug: Statin therapy, Behavioral: Standard care, Drug: Aspirin, Drug: Clopidogrel, Drug: Placebo Niaspan, Drug: Placebo Ezetimibe, Procedure: Percutaneous transluminal angioplasty (PTA) | Intervention Type: DRUG; Name: Ezetimibe; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Niaspan; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Statin therapy; Assigned to Arm(s): 1, 2 | Intervention Type: BEHAVIORAL; Name: Standard care; Assigned to Arm(s): 1, 2 | Intervention Type: DRUG; Name: Aspirin; Assigned to Arm(s): 1, 2 | Intervention Type: DRUG; Name: Clopidogrel; Assigned to Arm(s): 1, 2 | Intervention Type: DRUG; Name: Placebo Niaspan; Assigned to Arm(s): 2 | Intervention Type: DRUG; Name: Placebo Ezetimibe; Assigned to Arm(s): 2 | Intervention Type: PROCEDURE; Name: Percutaneous transluminal angioplasty (PTA); Assigned to Arm(s): 1, 2
C: Arm Label: EZ/Simva; Type: EXPERIMENTAL; Interventions: Drug: ezetimibe (plus simvastatin) | Arm Label: Placebo/Simva; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo (plus simvastatin) | Intervention Type: DRUG; Name: ezetimibe (plus simvastatin); Assigned to Arm(s): EZ/Simva | Intervention Type: DRUG; Name: placebo (plus simvastatin); Assigned to Arm(s): Placebo/Simva
D: Arm Label: Evolocumab; Type: EXPERIMENTAL; Interventions: Biological: Evolocumab, Drug: Atorvastatin, Drug: Ezetimibe, Other: Diet Only | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo, Drug: Atorvastatin, Drug: Ezetimibe, Other: Diet Only | Intervention Type: BIOLOGICAL; Name: Evolocumab; Assigned to Arm(s): Evolocumab | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: Atorvastatin; Assigned to Arm(s): Evolocumab, Placebo | Intervention Type: DRUG; Name: Ezetimibe; Assigned to Arm(s): Evolocumab, Placebo | Intervention Type: OTHER; Name: Diet Only; Assigned to Arm(s): Evolocumab, Placebo

Answer: C