Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Comparison of the Immunogenicity and Descriptive Safety of a Live Attenuated Herpes Zoster Vaccine and the Glaxo Smith Kline (GSK) Herpes Zoster Recombinant HZ/su Candidate Vaccine in 50-59 Year Old and 70-85 Year Old Vaccine Recipients
Brief Summary: This study will compare the two vaccines that have been developed to prevent and/or lessen the effects of shingles. One vaccine is live (Zostavax, licensed by FDA) and the other, herpes zoster subunit (HZ/su), contains a piece of the shingles virus (not live) and an ingredient that may enhance the body's immune response to the vaccine, and is currently investigational. The vaccines are being compared to assess their ability to stimulated protection against shingles. The study will provide an opportunity to determine the safety profile of each vaccine in a single trial. The study will also look at the effect of age on the immune response to the two vaccines and on the persistence of these responses.


Options:
A: Arm Label: GSK1437173A _LD Group; Type: EXPERIMENTAL; Interventions: Biological: Herpes Zoster vaccine GSK1437173A Low Dose | Arm Label: GSK1437173A _MD Group; Type: EXPERIMENTAL; Interventions: Biological: Herpes Zoster vaccine GSK1437173A Medium Dose | Arm Label: GSK1437173A _HD Group; Type: EXPERIMENTAL; Interventions: Biological: Herpes Zoster vaccine GSK1437173A High Dose | Arm Label: Placebo + GSK1437173A _HD Group; Type: PLACEBO_COMPARATOR; Interventions: Biological: Herpes Zoster vaccine GSK1437173A High Dose, Biological: Placebo | Arm Label: GSK1437173A_MODIFIED GROUP; Type: ACTIVE_COMPARATOR; Interventions: Biological: Herpes Zoster vaccine GSK1437173A Modified | Intervention Type: BIOLOGICAL; Name: Herpes Zoster vaccine GSK1437173A Low Dose; Assigned to Arm(s): GSK1437173A _LD Group | Intervention Type: BIOLOGICAL; Name: Herpes Zoster vaccine GSK1437173A Medium Dose; Assigned to Arm(s): GSK1437173A _MD Group | Intervention Type: BIOLOGICAL; Name: Herpes Zoster vaccine GSK1437173A High Dose; Assigned to Arm(s): GSK1437173A _HD Group, Placebo + GSK1437173A _HD Group | Intervention Type: BIOLOGICAL; Name: Herpes Zoster vaccine GSK1437173A Modified; Assigned to Arm(s): GSK1437173A_MODIFIED GROUP | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Placebo + GSK1437173A _HD Group
B: Arm Label: GSK1437173A formulation 1 Group; Type: EXPERIMENTAL; Interventions: Biological: Herpes zoster vaccine GSK1437173A | Arm Label: GSK1437173A formulation 2 Group; Type: EXPERIMENTAL; Interventions: Biological: Herpes zoster vaccine GSK1437173A | Arm Label: GSK1437173A formulation 3 Group; Type: EXPERIMENTAL; Interventions: Biological: Herpes zoster vaccine GSK1437173A | Arm Label: Control Group; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Intervention Type: BIOLOGICAL; Name: Herpes zoster vaccine GSK1437173A; Assigned to Arm(s): GSK1437173A formulation 1 Group, GSK1437173A formulation 2 Group, GSK1437173A formulation 3 Group | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Control Group
C: Arm Label: Arm 1; Type: EXPERIMENTAL; Interventions: Biological: Varicella-zoster vaccine | Arm Label: Arm 2; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Intervention Type: BIOLOGICAL; Name: Varicella-zoster vaccine; Assigned to Arm(s): Arm 1 | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Arm 2
D: Arm Label: A - Live zoster vaccine; Type: ACTIVE_COMPARATOR; Interventions: Biological: Zostavax, Biological: Placebo | Arm Label: B - recombinant zoster vaccine; Type: ACTIVE_COMPARATOR; Interventions: Biological: HZ/su vaccine | Arm Label: C - Live zoster vaccine; Type: ACTIVE_COMPARATOR; Interventions: Biological: Zostavax, Biological: Placebo | Arm Label: D - recombinant zoster vaccine; Type: ACTIVE_COMPARATOR; Interventions: Biological: HZ/su vaccine | Intervention Type: BIOLOGICAL; Name: Zostavax; Assigned to Arm(s): A - Live zoster vaccine, C - Live zoster vaccine | Intervention Type: BIOLOGICAL; Name: HZ/su vaccine; Assigned to Arm(s): B - recombinant zoster vaccine, D - recombinant zoster vaccine | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): A - Live zoster vaccine, C - Live zoster vaccine

Answer: D