Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase 2, Randomized, Open-Label Active-Comparator (Epoetin Alfa) and Single-Blind Placebo-Controlled, Dose-Ranging Safety and Exploratory Efficacy Study of FG-4592 in Subjects With End-Stage Renal Disease Receiving Maintenance Hemodialysis
Brief Summary: The primary objective of this study is to evaluate the efficacy and safety of roxadustat in participants with end-stage renal disease (ESRD) on maintenance hemodialysis (HD) therapy, previously treated with intravenous (IV) epoetin alfa.


Options:
A: Arm Label: Desidustat oral tablet; Type: ACTIVE_COMPARATOR; Interventions: Drug: Desidustat Oral Tablet | Arm Label: Epoetin Injection; Type: EXPERIMENTAL; Interventions: Drug: Epoetin Alfa | Intervention Type: DRUG; Name: Desidustat Oral Tablet; Assigned to Arm(s): Desidustat oral tablet | Intervention Type: DRUG; Name: Epoetin Alfa; Assigned to Arm(s): Epoetin Injection
B: Arm Label: 0.5mg GSK1278863; Type: EXPERIMENTAL; Interventions: Drug: GSK1278863 | Arm Label: 2mg GSK1278863; Type: EXPERIMENTAL; Interventions: Drug: GSK1278863 | Arm Label: 5mg GSK1278863; Type: EXPERIMENTAL; Interventions: Drug: GSK1278863 | Arm Label: Placebo; Type: EXPERIMENTAL; Interventions: Other: Placebo | Intervention Type: DRUG; Name: GSK1278863; Assigned to Arm(s): 0.5mg GSK1278863, 2mg GSK1278863, 5mg GSK1278863 | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: Vadadustat 600 mg; Type: EXPERIMENTAL; Interventions: Drug: Vadadustat | Arm Label: Vadadustat 750 mg; Type: EXPERIMENTAL; Interventions: Drug: Vadadustat | Arm Label: Vadadustat 900 mg; Type: EXPERIMENTAL; Interventions: Drug: Vadadustat | Arm Label: Erythropoiesis-stimulating agent; Type: OTHER; Interventions: Drug: Darbepoetin alfa, Drug: Epoetin alfa | Intervention Type: DRUG; Name: Vadadustat; Assigned to Arm(s): Vadadustat 600 mg, Vadadustat 750 mg, Vadadustat 900 mg | Intervention Type: DRUG; Name: Darbepoetin alfa; Assigned to Arm(s): Erythropoiesis-stimulating agent | Intervention Type: DRUG; Name: Epoetin alfa; Assigned to Arm(s): Erythropoiesis-stimulating agent
D: Arm Label: Cohort A-1 (Roxadustat 1.0 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-2 (Roxadustat 1.5 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-3 (Roxadustat 2.0 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-4 (Roxadustat 1.8 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-5 (Roxadustat 1.8 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-6 (Roxadustat 1.3 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-7 (Weight Tiered Roxadustat 70-100-150 mg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-8 (Weight Tiered Roxadustat 70-120-200 mg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-9 (Roxadustat 2.0 mg/kg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-10 (Weight Tiered Roxadustat 70-120-200 mg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohorts A (Epoetin Alfa); Type: ACTIVE_COMPARATOR; Interventions: Drug: Epoetin Alfa | Arm Label: Cohort B-1 (Roxadustat 1.5 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort B-2 (Roxadustat 2.0 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort B (Epoetin Alfa); Type: ACTIVE_COMPARATOR; Interventions: Drug: Epoetin Alfa | Arm Label: Cohort B (Placebo); Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Intervention Type: DRUG; Name: Roxadustat; Assigned to Arm(s): Cohort A-1 (Roxadustat 1.0 mg/kg TIW), Cohort A-10 (Weight Tiered Roxadustat 70-120-200 mg), Cohort A-2 (Roxadustat 1.5 mg/kg TIW), Cohort A-3 (Roxadustat 2.0 mg/kg TIW), Cohort A-4 (Roxadustat 1.8 mg/kg TIW), Cohort A-5 (Roxadustat 1.8 mg/kg TIW), Cohort A-6 (Roxadustat 1.3 mg/kg TIW), Cohort A-7 (Weight Tiered Roxadustat 70-100-150 mg), Cohort A-8 (Weight Tiered Roxadustat 70-120-200 mg), Cohort A-9 (Roxadustat 2.0 mg/kg), Cohort B-1 (Roxadustat 1.5 mg/kg TIW), Cohort B-2 (Roxadustat 2.0 mg/kg TIW) | Intervention Type: DRUG; Name: Epoetin Alfa; Assigned to Arm(s): Cohort B (Epoetin Alfa), Cohorts A (Epoetin Alfa) | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Cohort B (Placebo)

Answer: D