Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Double-Blind (Test Products and Placebo), Chronic Dosing (7 Days), Four-Period, Eight-Treatment, Placebo-Controlled, Incomplete Block, Cross-Over, Multi-Center Study to Assess Efficacy and Safety of Two Doses of PT003, Two Doses of PT005 and One Dose of PT001 in Patients With Moderate to Very Severe COPD, Compared With Foradil® Aerolizer® (12 μg, Open-Label) and Spiriva® Handihaler® (18 μg, Open-Label) as Active Controls
Brief Summary: The purpose of this study is to evaluate, after 1 week of dosing, the efficacy and safety of PT003 compared with its individual components (PT001 and PT005), placebo and two active comparators to demonstrate superiority of the combination to its components, and to assess the relative contribution of the components compared with placebo, in patients with moderate to very severe COPD.


Options:
A: Arm Label: Olodaterol 5 mcg QD; Type: ACTIVE_COMPARATOR; Interventions: Drug: Olodaterol, Device: Respimat | Arm Label: Placebo QD; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Device: Respimat | Arm Label: Tiotropium 5 mcg QD; Type: ACTIVE_COMPARATOR; Interventions: Drug: Tiotropium, Device: Respimat | Arm Label: Tiotropium + olodaterol low dose QD; Type: EXPERIMENTAL; Interventions: Drug: Tiotropium + Olodaterol, Device: Respimat | Arm Label: Tiotropium + olodaterol high dose; Type: EXPERIMENTAL; Interventions: Drug: tiotropium + Olodaterol, Device: Respimat | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo QD | Intervention Type: DRUG; Name: Tiotropium + Olodaterol; Assigned to Arm(s): Tiotropium + olodaterol low dose QD | Intervention Type: DRUG; Name: tiotropium + Olodaterol; Assigned to Arm(s): Tiotropium + olodaterol high dose | Intervention Type: DRUG; Name: Tiotropium; Assigned to Arm(s): Tiotropium 5 mcg QD | Intervention Type: DRUG; Name: Olodaterol; Assigned to Arm(s): Olodaterol 5 mcg QD | Intervention Type: DEVICE; Name: Respimat; Assigned to Arm(s): Olodaterol 5 mcg QD, Placebo QD, Tiotropium + olodaterol high dose, Tiotropium + olodaterol low dose QD, Tiotropium 5 mcg QD
B: Arm Label: GSK573719/GW642444 125/25; Type: EXPERIMENTAL; Interventions: Drug: GSK573719/GW642444 125/25 | Arm Label: GSK573719/GW642444 62.5/25; Type: EXPERIMENTAL; Interventions: Drug: GSK573719/GW642444 62.5/25 | Arm Label: GSK573719; Type: EXPERIMENTAL; Interventions: Drug: GSK573719 | Arm Label: tiotropium bromide; Type: ACTIVE_COMPARATOR; Interventions: Drug: tiotropium bromide | Intervention Type: DRUG; Name: GSK573719/GW642444 125/25; Assigned to Arm(s): GSK573719/GW642444 125/25 | Intervention Type: DRUG; Name: GSK573719/GW642444 62.5/25; Assigned to Arm(s): GSK573719/GW642444 62.5/25 | Intervention Type: DRUG; Name: GSK573719; Assigned to Arm(s): GSK573719 | Intervention Type: DRUG; Name: tiotropium bromide; Assigned to Arm(s): tiotropium bromide
C: Arm Label: Sequence A; Type: PLACEBO_COMPARATOR; Interventions: Drug: QAB149, Drug: Placebo | Arm Label: Sequence B; Type: ACTIVE_COMPARATOR; Interventions: Drug: QAB149, Drug: NVA237 | Intervention Type: DRUG; Name: QAB149; Assigned to Arm(s): Sequence A, Sequence B | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Sequence A | Intervention Type: DRUG; Name: NVA237; Assigned to Arm(s): Sequence B
D: Arm Label: Inhaled PT003 (Dose 1); Type: EXPERIMENTAL; Interventions: Drug: PT003 MDI | Arm Label: Inhaled PT003 (Dose 2); Type: EXPERIMENTAL; Interventions: Drug: PT003 MDI | Arm Label: Inhaled PT005 (Dose 1); Type: EXPERIMENTAL; Interventions: Drug: PT005 MDI | Arm Label: Inhaled PT005 (Dose 2); Type: EXPERIMENTAL; Interventions: Drug: PT005 MDI | Arm Label: Inhaled Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo MDI | Arm Label: Tiotropium bromide 18 μg (Spiriva Handihaler®); Type: ACTIVE_COMPARATOR; Interventions: Drug: Tiotropium bromide 18 μg (Spiriva Handihaler®) | Arm Label: Formoterol Fumarate 12 μg (Foradil® Aerolizer®); Type: ACTIVE_COMPARATOR; Interventions: Drug: Formoterol Fumarate 12 μg (Foradil® Aerolizer®) | Arm Label: Inhaled PT001 (Dose 1); Type: EXPERIMENTAL; Interventions: Drug: PT001 MDI | Intervention Type: DRUG; Name: PT003 MDI; Assigned to Arm(s): Inhaled PT003 (Dose 1), Inhaled PT003 (Dose 2) | Intervention Type: DRUG; Name: PT005 MDI; Assigned to Arm(s): Inhaled PT005 (Dose 1), Inhaled PT005 (Dose 2) | Intervention Type: DRUG; Name: Placebo MDI; Assigned to Arm(s): Inhaled Placebo | Intervention Type: DRUG; Name: Tiotropium bromide 18 μg (Spiriva Handihaler®); Assigned to Arm(s): Tiotropium bromide 18 μg (Spiriva Handihaler®) | Intervention Type: DRUG; Name: Formoterol Fumarate 12 μg (Foradil® Aerolizer®); Assigned to Arm(s): Formoterol Fumarate 12 μg (Foradil® Aerolizer®) | Intervention Type: DRUG; Name: PT001 MDI; Assigned to Arm(s): Inhaled PT001 (Dose 1)

Answer: D