Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: N/A
Brief Summary: Aims of the study:

This is a single blind randomized-controlled trial to test the feasibility and the effects of a task oriented training on locomotor function, mobility and balance in multiple sclerosis subjects with moderate gait impairments (EDSS 4 - 5,5). The control group will not be treated with a specific physical therapy (usual care).

Subjects and methods:

60 multiple sclerosis patients will be recruited in an outpatient rehabilitation clinic (Azienda Ospedaliero-Universitaria di Ferrara).

Informed consent will be obtained. Participants will be randomized to (TOCT) task-oriented training (experimental group) or usual care (control group) through a randomization stratification approach, according to a block randomization of 6.

The experimental group will receive 10 task-oriented training sessions over 2 weeks (5 sessions/week=intensive training). Three subjects with a supervisor physiotherapist will take part at the TOCT.

Feasibility outcome will be measured with a specific questionnaire. Treatment efficacy outcome measures will be clinical test for gait speed (10m walking test), walking endurance (six minute walking test), balance (Dynamic Gait Index) and mobility (Time Up and Go Test); a structured interview for the performance(Lower Extremity Mal); self-assessment questionnaire for motor fatigue (Fatigue Severity Scale FSS), multiple sclerosis physical and psychological impact (multiple sclerosis impact scale MSIS-29), walking ability (multiple sclerosis walking scale MSWS-12).

Outcome measures will be assessed the week before the treatment (T0), after the treatment (T1) and at 3 months follow-up (T2) to evaluate treatments retention, by a clinician blinded to the treatment.


Options:
A: Arm Label: Task-oriented circuit class training; Type: EXPERIMENTAL; Interventions: Behavioral: Task-oriented circuit class training | Arm Label: Usual Care; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: usual care | Intervention Type: BEHAVIORAL; Name: Task-oriented circuit class training; Assigned to Arm(s): Task-oriented circuit class training | Intervention Type: BEHAVIORAL; Name: usual care; Assigned to Arm(s): Usual Care
B: Arm Label: Endurance training; Type: EXPERIMENTAL; Interventions: Behavioral: Endurance training, Behavioral: Standard care | Arm Label: Standard care; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Standard care | Intervention Type: BEHAVIORAL; Name: Endurance training; Assigned to Arm(s): Endurance training | Intervention Type: BEHAVIORAL; Name: Standard care; Assigned to Arm(s): Endurance training, Standard care
C: Arm Label: Arm 1; Type: EXPERIMENTAL; Interventions: Device: Body-weight supported treadmill, Device: Lokomat | Arm Label: Arm 2; Type: EXPERIMENTAL; Interventions: Device: Body-weight supported treadmill, Device: Lokomat | Intervention Type: DEVICE; Name: Body-weight supported treadmill; Assigned to Arm(s): Arm 1 | Intervention Type: DEVICE; Name: Lokomat; Assigned to Arm(s): Arm 1 | Intervention Type: DEVICE; Name: Body-weight supported treadmill; Assigned to Arm(s): Arm 2 | Intervention Type: DEVICE; Name: Lokomat; Assigned to Arm(s): Arm 2
D: Arm Label: Exercise: Vestibular Rehabilitation; Type: EXPERIMENTAL; Interventions: Other: Exercise: Vestibular Rehabilitation | Arm Label: Exercise Control; Type: ACTIVE_COMPARATOR; Interventions: Other: Exercise | Arm Label: Wait-listed Control; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: OTHER; Name: Exercise: Vestibular Rehabilitation; Assigned to Arm(s): Exercise: Vestibular Rehabilitation | Intervention Type: OTHER; Name: Exercise; Assigned to Arm(s): Exercise Control

Answer: A