Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Pilot Randomized, Placebo-Controlled, Crossover Study of the Effect of the Nicotine Nasal Spray and Varenicline on Cigarette Smoking Following Methadone Dosing in Methadone-Maintained Patients
Brief Summary: The objective is to provide a preliminary test of the ability of two pharmacological treatments, the nicotine nasal spray and varenicline, relative to placebos, to reduce smoking during the 4 hours following methadone dosing.


Options:
A: Arm Label: Order 1; Type: EXPERIMENTAL; Interventions: Drug: Nicotine Nasal Spray, Drug: Varenicline, Drug: Placebo Nasal Spray, Drug: Placebo Varenicline | Arm Label: Order 2; Type: EXPERIMENTAL; Interventions: Drug: Nicotine Nasal Spray, Drug: Varenicline, Drug: Placebo Nasal Spray, Drug: Placebo Varenicline | Arm Label: Order 3; Type: EXPERIMENTAL; Interventions: Drug: Nicotine Nasal Spray, Drug: Varenicline, Drug: Placebo Nasal Spray, Drug: Placebo Varenicline | Arm Label: Order 4; Type: EXPERIMENTAL; Interventions: Drug: Nicotine Nasal Spray, Drug: Varenicline, Drug: Placebo Nasal Spray, Drug: Placebo Varenicline | Intervention Type: DRUG; Name: Nicotine Nasal Spray; Assigned to Arm(s): Order 1, Order 2, Order 3, Order 4 | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): Order 1, Order 2, Order 3, Order 4 | Intervention Type: DRUG; Name: Placebo Nasal Spray; Assigned to Arm(s): Order 1, Order 2, Order 3, Order 4 | Intervention Type: DRUG; Name: Placebo Varenicline; Assigned to Arm(s): Order 1, Order 2, Order 3, Order 4
B: Arm Label: Arm I: nicotine inhaler cartridges; Type: EXPERIMENTAL; Interventions: Drug: nicotine | Arm Label: Arm II: bupropion; Type: EXPERIMENTAL; Interventions: Drug: bupropion hydrochloride | Arm Label: Arm III: nicotine inhaler cartridges; Type: EXPERIMENTAL; Interventions: Drug: nicotine | Arm Label: Arm IV: bupropion; Type: EXPERIMENTAL; Interventions: Drug: bupropion hydrochloride | Arm Label: Arm V: placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Arm Label: Arm VI: nicotine inhaler cartridges; Type: EXPERIMENTAL; Interventions: Drug: nicotine | Arm Label: Arm VII: placebo inhaler; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Arm Label: Arm VIII: nicotine inhaler cartridges; Type: EXPERIMENTAL; Interventions: Drug: nicotine | Arm Label: Arm IX: placebo inhaler cartridges; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Arm Label: Arm X: bupropion; Type: EXPERIMENTAL; Interventions: Drug: bupropion hydrochloride | Arm Label: Arm XI: placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Arm Label: Arm XII: nicotine inhaler cartridges; Type: EXPERIMENTAL; Interventions: Drug: nicotine | Arm Label: Arm XIII: placebo inhaler cartridges; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Arm Label: Arm XIV: nicotine inhaler cartridges; Type: EXPERIMENTAL; Interventions: Drug: nicotine | Arm Label: Arm XV: placebo inhaler cartridges; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Intervention Type: OTHER; Name: placebo; Assigned to Arm(s): Arm IX: placebo inhaler cartridges, Arm V: placebo, Arm VII: placebo inhaler, Arm XI: placebo, Arm XIII: placebo inhaler cartridges, Arm XV: placebo inhaler cartridges | Intervention Type: DRUG; Name: bupropion hydrochloride; Assigned to Arm(s): Arm II: bupropion, Arm IV: bupropion, Arm X: bupropion | Intervention Type: DRUG; Name: nicotine; Assigned to Arm(s): Arm I: nicotine inhaler cartridges, Arm III: nicotine inhaler cartridges, Arm VI: nicotine inhaler cartridges, Arm VIII: nicotine inhaler cartridges, Arm XII: nicotine inhaler cartridges, Arm XIV: nicotine inhaler cartridges
C: Arm Label: Group I (varenicline and placebo); Type: EXPERIMENTAL; Interventions: Other: Placebo, Other: Tobacco Cessation Counseling, Drug: Varenicline | Arm Label: Group II (placebo, nicotine patch and lozenge); Type: PLACEBO_COMPARATOR; Interventions: Drug: Nicotine Lozenge, Drug: Nicotine Patch, Other: Placebo, Other: Tobacco Cessation Counseling | Intervention Type: DRUG; Name: Nicotine Lozenge; Assigned to Arm(s): Group II (placebo, nicotine patch and lozenge) | Intervention Type: DRUG; Name: Nicotine Patch; Assigned to Arm(s): Group II (placebo, nicotine patch and lozenge) | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Group I (varenicline and placebo), Group II (placebo, nicotine patch and lozenge) | Intervention Type: OTHER; Name: Tobacco Cessation Counseling; Assigned to Arm(s): Group I (varenicline and placebo), Group II (placebo, nicotine patch and lozenge) | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): Group I (varenicline and placebo)
D: Arm Label: Placebo Control; Type: PLACEBO_COMPARATOR; Interventions: Behavioral: Smoking cessation counseling, Drug: Placebo | Arm Label: Experimental: Varenicline; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Smoking cessation counseling, Drug: Varenicline | Intervention Type: BEHAVIORAL; Name: Smoking cessation counseling; Assigned to Arm(s): Experimental: Varenicline, Placebo Control | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo Control | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): Experimental: Varenicline

Answer: A