Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomised, Double-blind, Placebo-controlled, Dose-ranging Phase II Study of APD421 for the Prevention of Post-operative Nausea and Vomiting
Brief Summary: To assess the efficacy and safety of different doses of APD421 in the prevention of post-operative nausea and vomiting (PONV) in adult patients at moderate to high-risk of PONV. Patients must be undergoing elective surgery under general anaesthesia (hysterectomy (any surgical technique), cholecystectomy (any surgical technique) or "other" elective surgery scheduled to last at least one hour from induction of anaesthesia), requiring at least one overnight stay in hospital, and have at least 2 of the following risk factors for PONV: Past history of PONV and/or motion sickness; Non-smoking status; Female gender; Planned opiate use for post-operative analgesia.


Options:
A: Arm Label: dexamethasone; Type: PLACEBO_COMPARATOR; Interventions: Drug: Dexamethasone iv injection | Arm Label: dexamethasone, haloperiol 1mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Dexamethasone, haloperidol | Arm Label: dexamethasone + haloperidol 2mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Dexamethasone, haloperidol | Intervention Type: DRUG; Name: Dexamethasone iv injection; Assigned to Arm(s): dexamethasone | Intervention Type: DRUG; Name: Dexamethasone, haloperidol; Assigned to Arm(s): dexamethasone, haloperiol 1mg | Intervention Type: DRUG; Name: Dexamethasone, haloperidol; Assigned to Arm(s): dexamethasone + haloperidol 2mg
B: Arm Label: Dexamethasone; Type: ACTIVE_COMPARATOR; Interventions: Drug: Dexamethasone, Drug: Morphine, Drug: Zofran, Drug: Paracetamol, Drug: Ibuprofen | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo, Drug: Morphine, Drug: Zofran, Drug: Paracetamol, Drug: Ibuprofen | Intervention Type: DRUG; Name: Dexamethasone; Assigned to Arm(s): Dexamethasone | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: Morphine; Assigned to Arm(s): Dexamethasone, Placebo | Intervention Type: DRUG; Name: Zofran; Assigned to Arm(s): Dexamethasone, Placebo | Intervention Type: DRUG; Name: Paracetamol; Assigned to Arm(s): Dexamethasone, Placebo | Intervention Type: DRUG; Name: Ibuprofen; Assigned to Arm(s): Dexamethasone, Placebo
C: Arm Label: Methylprednisolone; Type: EXPERIMENTAL; Interventions: Drug: Methylprednisolone 125mg | Arm Label: placebo/sodium chloride; Type: PLACEBO_COMPARATOR; Interventions: Drug: Sodium Chloride 2 ml | Intervention Type: DRUG; Name: Methylprednisolone 125mg; Assigned to Arm(s): Methylprednisolone | Intervention Type: DRUG; Name: Sodium Chloride 2 ml; Assigned to Arm(s): placebo/sodium chloride
D: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: Low dose APD421; Type: EXPERIMENTAL; Interventions: Drug: APD421 | Arm Label: Mid Dose APD421; Type: EXPERIMENTAL; Interventions: Drug: APD421 | Arm Label: High Dose APD421; Type: EXPERIMENTAL; Interventions: Drug: APD421 | Intervention Type: DRUG; Name: APD421; Assigned to Arm(s): High Dose APD421, Low dose APD421, Mid Dose APD421 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo

Answer: D