Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Carbon Dioxide, Oxygen and Mean Arterial Pressure After Cardiac Arrest and Resuscitation - Targeting High vs. Low Normal Values
Brief Summary: The COMACARE trial is a pilot multicenter randomized trial to assess the feasibility and effect on brain injury markers of targeting low or high normal arterial oxygen tension (PaO2), arterial carbon dioxide tension (PaCO2) and mean arterial pressure (MAP) in comatose, mechanically ventilated patients after out-of-hospital cardiac arrest. Using factorial design, participants are randomized at admission to intensive care unit to one of eight groups targeting either low or high normal values of PaO2, PaCO2 and MAP for 36 h. In this way, investigators will be assessing the feasibility and effect of all three variables at the same time.

The primary outcome is serum concentration of neuron-specific enolase (NSE) at 48 h after cardiac arrest. Feasibility outcome is between-group separation in PaO2, PaCO2 and MAP levels. Secondary outcomes include continuous monitoring of cerebral oxygenation, EEG and ECG for 48 h, the levels of NSE, S100B and cardiac troponin at randomization and 24, 48 and 72 h after cardiac arrest and neurological assessment at 6 months after cardiac arrest.


Options:
A: Arm Label: Oxygen therapy; Type: OTHER; Interventions: Other: Oxygen therapy | Arm Label: No oxygen therapy; Type: OTHER; Interventions: Other: No oxygen therapy | Intervention Type: OTHER; Name: Oxygen therapy; Assigned to Arm(s): Oxygen therapy | Intervention Type: OTHER; Name: No oxygen therapy; Assigned to Arm(s): No oxygen therapy
B: Arm Label: normoxia and isotonic saline; Type: PLACEBO_COMPARATOR; Interventions: Drug: oxygen and saline | Arm Label: normoxia and 3% hypertonic saline; Type: ACTIVE_COMPARATOR; Interventions: Drug: oxygen and saline | Arm Label: hyperoxia and isotonic saline; Type: ACTIVE_COMPARATOR; Interventions: Drug: oxygen and saline | Arm Label: hyperoxia and 3% hypertonic saline; Type: ACTIVE_COMPARATOR; Interventions: Drug: oxygen and saline | Intervention Type: DRUG; Name: oxygen and saline; Assigned to Arm(s): hyperoxia and 3% hypertonic saline, hyperoxia and isotonic saline, normoxia and 3% hypertonic saline, normoxia and isotonic saline
C: Arm Label: Group 1; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: Low normal PaO2, Other: Low normal MAP | Arm Label: Group 2; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: Low normal PaO2, Other: Low normal MAP | Arm Label: Group 3; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: High normal PaO2, Other: Low normal MAP | Arm Label: Group 4; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: High normal PaO2, Other: Low normal MAP | Arm Label: Group 5; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: Low normal PaO2, Other: High normal MAP | Arm Label: Group 6; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: Low normal PaO2, Other: High normal MAP | Arm Label: Group 7; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: High normal PaO2, Other: High normal MAP | Arm Label: Group 8; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: High normal PaO2, Other: High normal MAP | Intervention Type: OTHER; Name: Low normal PaCO2; Assigned to Arm(s): Group 1, Group 3, Group 5, Group 7 | Intervention Type: OTHER; Name: High normal PaCO2; Assigned to Arm(s): Group 2, Group 4, Group 6, Group 8 | Intervention Type: OTHER; Name: Low normal PaO2; Assigned to Arm(s): Group 1, Group 2, Group 5, Group 6 | Intervention Type: OTHER; Name: High normal PaO2; Assigned to Arm(s): Group 3, Group 4, Group 7, Group 8 | Intervention Type: OTHER; Name: Low normal MAP; Assigned to Arm(s): Group 1, Group 2, Group 3, Group 4 | Intervention Type: OTHER; Name: High normal MAP; Assigned to Arm(s): Group 5, Group 6, Group 7, Group 8
D: Arm Label: Nasal oxygen; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nasal oxygen | Arm Label: Nasal Air; Type: PLACEBO_COMPARATOR; Interventions: Drug: Regular nasal air | Intervention Type: DRUG; Name: Nasal oxygen; Assigned to Arm(s): Nasal oxygen | Intervention Type: DRUG; Name: Regular nasal air; Assigned to Arm(s): Nasal Air

Answer: C