Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Double Blind, Randomized, Placebo Controlled Trial to Evaluate the Efficacy and Safety of FOSTRAP Chewing Gum in Patients With Chronic Kidney Disease and Hyperphosphatemia.
Brief Summary: The phosphorus content in saliva is increased in chronic kidney disease. We hypothesize that a chewing gum that binds salivary phosphorus would be a novel, effective agent to reduce serum levels of phosphorus in patients with chronic kidney disease. We are testing this hypothesis using a chewing gum called FOSTRAP which has been shown to be effective in a small, non-randomized study in patients with chronic kidney disease on hemodialysis.


Options:
A: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: Niacinamide | Arm Label: 2; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Niacinamide; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): 2
B: Arm Label: ESRD: FOSTRAP Chewing Gum; Type: ACTIVE_COMPARATOR; Interventions: Other: FOSTRAP Chewing Gum | Arm Label: CKD: FOSTRAP Chewing Gum; Type: ACTIVE_COMPARATOR; Interventions: Other: FOSTRAP Chewing Gum | Arm Label: ESRD Matching Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo chewing gum | Arm Label: CKD Matching Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo chewing gum | Intervention Type: OTHER; Name: FOSTRAP Chewing Gum; Assigned to Arm(s): ESRD: FOSTRAP Chewing Gum | Intervention Type: OTHER; Name: FOSTRAP Chewing Gum; Assigned to Arm(s): ESRD: FOSTRAP Chewing Gum | Intervention Type: OTHER; Name: FOSTRAP Chewing Gum; Assigned to Arm(s): CKD: FOSTRAP Chewing Gum | Intervention Type: OTHER; Name: FOSTRAP Chewing Gum; Assigned to Arm(s): ESRD: FOSTRAP Chewing Gum | Intervention Type: OTHER; Name: Placebo chewing gum; Assigned to Arm(s): CKD Matching Placebo, ESRD Matching Placebo
C: Arm Label: Chewing Arm 1; Type: ACTIVE_COMPARATOR; Interventions: Other: K2CG chewing gum | Arm Label: Chewing Arm 2; Type: PLACEBO_COMPARATOR; Interventions: Other: K2CG chewing gum | Arm Label: Chewing Arm 3; Type: ACTIVE_COMPARATOR; Interventions: Other: K2CG chewing gum | Arm Label: Chewing Arm 4; Type: ACTIVE_COMPARATOR; Interventions: Other: K2CG chewing gum | Intervention Type: OTHER; Name: K2CG chewing gum; Assigned to Arm(s): Chewing Arm 1, Chewing Arm 2, Chewing Arm 3, Chewing Arm 4 | Intervention Type: OTHER; Name: K2CG chewing gum; Assigned to Arm(s): Chewing Arm 1, Chewing Arm 2, Chewing Arm 3, Chewing Arm 4 | Intervention Type: OTHER; Name: K2CG chewing gum; Assigned to Arm(s): Chewing Arm 1, Chewing Arm 2, Chewing Arm 3, Chewing Arm 4 | Intervention Type: OTHER; Name: K2CG chewing gum; Assigned to Arm(s): Chewing Arm 1, Chewing Arm 2, Chewing Arm 3, Chewing Arm 4
D: Arm Label: Subjects with normal kidney function; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: High calcium diet 2000 mg/day, Dietary Supplement: Low calcium diet, 800 mg/day | Arm Label: CKD late Stage 3 and Stage 4; Type: EXPERIMENTAL; Interventions: Dietary Supplement: High calcium diet 2000 mg/day, Dietary Supplement: Low calcium diet, 800 mg/day | Intervention Type: DIETARY_SUPPLEMENT; Name: High calcium diet 2000 mg/day; Assigned to Arm(s): CKD late Stage 3 and Stage 4, Subjects with normal kidney function | Intervention Type: DIETARY_SUPPLEMENT; Name: Low calcium diet, 800 mg/day; Assigned to Arm(s): CKD late Stage 3 and Stage 4, Subjects with normal kidney function

Answer: B