Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase III Contact Tracing Trial Comparing the Diagnostic Performance of C-Tb to QuantiFERON®-TB Gold In-Tube, in Combination With a Double Blind Randomized Split Body Safety Assessment of C-Tb Versus 2 T.U. Tuberculin PPD RT23 SSI
Brief Summary: Tuberculosis (TB) continues to be the most important bacterial infection worldwide and therefore new improved diagnostic tests are needed to help doctors in diagnosing TB.

We are investigating a new skin test named C-Tb. Like the current tuberculin skin test (PPD), the C-Tb test is injected just under the skin and will, when positive, show redness and/or swelling at the injection site while a negative test will leave no reactions.

The aim of this trial is to test the C-Tb skin test in volunteers. The volunteers are divided into four groups:

* Negative control group: Must have no history of exposure to a person with tuberculosis disease.
* Occasional contact: Must be in contact with a person with tuberculosis disease between 6 hours/week and 6 hours/day
* Close contact: Must be in close contact with a person with tuberculosis disease for more than 6 hours/day for at least five days
* Positive control group: Must have a confirmed tuberculosis disease within the last 3 years.

The goals of this clinical trial are:

* To compare the C-Tb test to a blood test, the QuantiFERON test.
* To compare the C-Tb test to the PPD test that is currently being used.
* To assess the safety of the C-Tb test.


Options:
A: Arm Label: 0.1 µg C-Tb; Type: EXPERIMENTAL; Interventions: Biological: C-Tb | Arm Label: 2 T.U Tuberculin PPD RT 23 SSI; Type: ACTIVE_COMPARATOR; Interventions: Biological: Tuberculin PPD RT 23 SSI | Arm Label: 0.1 µg C-Tb / 2 T.U Tuberculin PPD; Type: EXPERIMENTAL; Interventions: Biological: C-Tb / Tuberculin PPD RT 23 SSI | Intervention Type: BIOLOGICAL; Name: C-Tb; Assigned to Arm(s): 0.1 µg C-Tb | Intervention Type: BIOLOGICAL; Name: Tuberculin PPD RT 23 SSI; Assigned to Arm(s): 2 T.U Tuberculin PPD RT 23 SSI | Intervention Type: BIOLOGICAL; Name: C-Tb / Tuberculin PPD RT 23 SSI; Assigned to Arm(s): 0.1 µg C-Tb / 2 T.U Tuberculin PPD
B: Arm Label: Control; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Interventional; Type: EXPERIMENTAL; Interventions: Diagnostic Test: Xpert MTB/RIF Ultra (Ultra) | Intervention Type: DIAGNOSTIC_TEST; Name: Xpert MTB/RIF Ultra (Ultra); Assigned to Arm(s): Interventional
C: Arm Label: Facility-based screening; Type: EXPERIMENTAL; Interventions: Other: Active TB case finding | Arm Label: Contact screening; Type: EXPERIMENTAL; Interventions: Other: Active TB case finding | Intervention Type: OTHER; Name: Active TB case finding; Assigned to Arm(s): Contact screening, Facility-based screening
D: Arm Label: 0.1 µg/0.1 mL C-Tb; Type: EXPERIMENTAL; Interventions: Biological: C-Tb | Arm Label: 2 T.U. Tuberculin PPD RT 23 SSI; Type: ACTIVE_COMPARATOR; Interventions: Biological: 2 T.U. Tuberculin PPD RT 23 SSI | Intervention Type: BIOLOGICAL; Name: C-Tb; Assigned to Arm(s): 0.1 µg/0.1 mL C-Tb | Intervention Type: BIOLOGICAL; Name: 2 T.U. Tuberculin PPD RT 23 SSI; Assigned to Arm(s): 2 T.U. Tuberculin PPD RT 23 SSI

Answer: D