Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Is Spironolactone Safe and Effective in the Treatment of Cardiovascular Disease in Mild Chronic Renal Failure?
Brief Summary: Patients with kidney failure have a poor survival rate that is due to a much higher than average rate of heart and vascular disease. The reason that kidney failure causes heart disease is unknown but recent research suggests that a hormone called aldosterone, which is increased in patients with kidney disease may damage the heart and blood vessels.

The investigators propose, using a randomized blinded trial, to find out whether drugs that inhibit the actions of aldosterone have beneficial effects on the cardiovascular system in patients with kidney failure


Options:
A: Intervention Type: DRUG; Name: losartan 100 mg orally once daily; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: spironolactone 25 mg orally once daily; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: placebo once orally once daily; Assigned to Arm(s): N/A
B: Arm Label: Finerenone(BAY94-8862)[2.5mg] + Placebo; Type: EXPERIMENTAL; Interventions: Drug: Finerenone (BAY94-8862), Drug: Placebo | Arm Label: Finerenone (BAY94-8862)[5mg] + Placebo; Type: EXPERIMENTAL; Interventions: Drug: Finerenone (BAY94-8862), Drug: Placebo | Arm Label: Finerenone (BAY94-8862)[7.5mg] + Placebo; Type: EXPERIMENTAL; Interventions: Drug: Finerenone (BAY94-8862), Drug: Placebo | Arm Label: Finerenone (BAY94-8862)[10mg] + Placebo; Type: EXPERIMENTAL; Interventions: Drug: Finerenone (BAY94-8862), Drug: Placebo | Arm Label: Finerenone (BAY94-8862)[15mg] + Placebo; Type: EXPERIMENTAL; Interventions: Drug: Finerenone (BAY94-8862), Drug: Placebo | Arm Label: Eplerenone [25 mg] + Placebo; Type: ACTIVE_COMPARATOR; Interventions: Drug: Placebo, Drug: Inspra (eplerenone) | Intervention Type: DRUG; Name: Finerenone (BAY94-8862); Assigned to Arm(s): Finerenone (BAY94-8862)[10mg] + Placebo, Finerenone (BAY94-8862)[15mg] + Placebo, Finerenone (BAY94-8862)[5mg] + Placebo, Finerenone (BAY94-8862)[7.5mg] + Placebo, Finerenone(BAY94-8862)[2.5mg] + Placebo | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Eplerenone [25 mg] + Placebo, Finerenone (BAY94-8862)[10mg] + Placebo, Finerenone (BAY94-8862)[15mg] + Placebo, Finerenone (BAY94-8862)[5mg] + Placebo, Finerenone (BAY94-8862)[7.5mg] + Placebo, Finerenone(BAY94-8862)[2.5mg] + Placebo | Intervention Type: DRUG; Name: Inspra (eplerenone); Assigned to Arm(s): Eplerenone [25 mg] + Placebo
C: Arm Label: Finerenone (BAY94-8862) (1.25 mg); Type: EXPERIMENTAL; Interventions: Drug: Finerenone (BAY94-8862) | Arm Label: Finerenone (BAY94-8862)(2.5 mg); Type: EXPERIMENTAL; Interventions: Drug: Finerenone (BAY94-8862) | Arm Label: Finerenone (BAY94-8862)(5 mg); Type: EXPERIMENTAL; Interventions: Drug: Finerenone (BAY94-8862) | Arm Label: Finerenone (BAY94-8862)(7.5 mg); Type: EXPERIMENTAL; Interventions: Drug: Finerenone (BAY94-8862) | Arm Label: Finerenone (BAY94-8862) (10 mg); Type: EXPERIMENTAL; Interventions: Drug: Finerenone (BAY94-8862) | Arm Label: Finerenone (BAY94-8862) (15 mg); Type: EXPERIMENTAL; Interventions: Drug: Finerenone (BAY94-8862) | Arm Label: Finerenone (BAY94-8862)(20 mg); Type: EXPERIMENTAL; Interventions: Drug: Finerenone (BAY94-8862) | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Finerenone (BAY94-8862); Assigned to Arm(s): Finerenone (BAY94-8862) (1.25 mg), Finerenone (BAY94-8862) (10 mg), Finerenone (BAY94-8862) (15 mg), Finerenone (BAY94-8862)(2.5 mg), Finerenone (BAY94-8862)(20 mg), Finerenone (BAY94-8862)(5 mg), Finerenone (BAY94-8862)(7.5 mg) | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
D: Arm Label: Spironolactone; Type: ACTIVE_COMPARATOR; Interventions: Drug: Spironolactone | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Spironolactone; Assigned to Arm(s): Spironolactone | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo

Answer: D