Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Phase II Randomized Controlled Trial to Evaluate a Brief Psychosocial Intervention Together With Early Palliative Care in Reducing Depressive Symptoms of Patients With Advanced Cancer Starting First Line Palliative Chemotherapy
Brief Summary: The purpose of this study is to determine whether a brief psychosocial intervention together with early palliative care are feasible, acceptable and effective in the reduction of depressive symptoms of patients with advanced cancers starting first line palliative chemotherapy.


Options:
A: Inclusion Criteria:

* COPD defined according to GOLD criteria (FEV1/FVC \< 70%) stage III or IV (FEV1 \< 50% predicted)

  * and/or long term treatment with either domiciliary oxygen or home mechanical ventilation
  * and or one or more hospital admissions in the previous year for an acute exacerbation

Exclusion Criteria:

* Moderate or severe cognitive impairment (MMSE\<20)
B: Inclusion Criteria:

* Age ≥ 18 years
* Dx of stage IV cancer (metastatic); refractory to hormonal therapy for breast or prostate cancer; stage III or IV for lung cancer.
* ECOG performance status ≤ 2 (estimated by primary oncologist)
* Prognosis of \>6 months to 2 years (estimated by primary oncologist)

Exclusion Criteria:

* Insufficient English literacy to complete questionnaires
* Inability of pass the cognitive screening test (SOMC - Short Orientation Memory Concentration test score \<20 or \>10 errors)
C: DISEASE CHARACTERISTICS:

* Diagnosis of 1 of the following advanced cancers:

  * Stage IIIB or IV non-small cell lung cancer
  * Extensive stage small cell lung cancer
  * Stage IV breast cancer

    * Poor prognostic indicators (conferring likelihood of ≤ 2 years survival), including, but not limited to, any of the following:

      * Visceral crisis
      * Lung or liver metastasis
      * Estrogen receptor-negative disease
      * HER2/neu-positive disease
      * Progressive or recurrent disease during or within 2 years of first treatment
  * Unresectable stage III or stage IV gastrointestinal cancers
  * Stage IV genitourinary cancers

    * Prostate cancer must be hormone refractory
* Hormone receptor status:

  * Not specified

PATIENT CHARACTERISTICS:

Sex

* Not specified

Menopausal status

* Not specified

Performance status

* Not specified

Life expectancy

* Not specified

Hematopoietic

* Not specified

Hepatic

* Not specified

Renal

* Not specified

Other

* No dementia or significant confusion (i.e., Mini Mental Exam score \< 25)
* No Axis I psychiatric disorders (DSM-IV), including any of the following:

  * Schizophrenia
  * Bipolar disorder
  * Active substance use disorder

PRIOR CONCURRENT THERAPY:

Endocrine therapy

* See Disease Characteristics
D: Inclusion Criteria:

* Age ≥ 18 years and \<75 years;
* Adequate knowledge about the cancer diagnosis;
* Starting first line palliative antineoplastic treatment;
* Eastern Cooperative Oncology Group Performance Status (ECOG-PS) ≤ 2;
* Life expectancy\> 6 months and \<24 months (as per the medical oncologist);
* Must have on the following diagnoses:

Metastatic or unresectable recurrent breast cancer; Stage IIIC or IV recurrent platinum-resistant ovarian cancer; Metastatic or unresectable recurrent cervix cancer; Metastatic or unresectable recurrent endometrial cancer; Metastatic or unresectable recurrent head and neck cancer (after previous radiotherapy); Hormone-refractory metastatic or unresectable recurrent prostate cancer; Metastatic or unresectable recurrent genitourinary cancer; Metastatic or unresectable recurrent non-small cell lung cancer; Extensive-stage or recurrent small cell lung cancer; Metastatic or unresectable recurrent gastrointestinal cancer;

Exclusion Criteria:

* Currently undergoing any psychological treatment due to a psychological disorder;
* Currently using antidepressants to treat depressive disorders and / or anxiety;
* Any cognitive deficit or attention problem that could interfere in the ability to answer questionnaires or understand the study aims (as per investigator);
* Current or previous established diagnosis of any of the following psychological conditions: Substance-Related Disorders; Schizophrenia and Other Psychotic Disorders; Mood Disorders (Depressive Disorders, Bipolar Disorders); Anxiety Disorders; Dissociative Disorders; Personality Disorders; and / or a history of suicide attempt;
* Patients with single resected metastasis;
* Any co-morbid condition, which, in the opinion of the investigator, could interfere with the safety, the compliance with the study or with the interpretation of the results.
* Patients unable to go to the hospital for the study visits, regardless of the reason.

Answer: D