Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Lactobacillus GG to Enhance the Immunogenicity of Influenza Vaccine in Healthy Adults - Proof of Concept Study
Brief Summary: The purpose of this study is to determine whether the food supplement called Lactobacillus rhamnosus GG (LGG) may help boost the effectiveness of the nasal flu vaccine. Preliminary data from several studies of healthy volunteers suggest that LGG boosts the immune response to vaccines. Fifty-two subjects will be recruited into the study, all will receive the nasal flu vaccine. Twenty-six will receive capsules that contain LGG, 26 will receive placebo capsules. Blood and nasal specimens will be collected weekly for four weeks and at eight weeks to evaluate the initial mucosal and systemic immune response to the immunization. This study will provide preliminary data on whether the immune response of healthy adults to the nasal influenza vaccine can be boosted by LGG.


Options:
A: Intervention Type: BIOLOGICAL; Name: pneumococcal polysaccharide and protein conjugate vaccines; Assigned to Arm(s): N/A
B: Arm Label: treatment; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Lactobacillus rhamnosus, Biological: Influenza Virus Vaccine Live, Intranasal | Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: placebo control, Biological: Influenza Virus Vaccine Live, Intranasal | Intervention Type: DIETARY_SUPPLEMENT; Name: Lactobacillus rhamnosus; Assigned to Arm(s): treatment | Intervention Type: DIETARY_SUPPLEMENT; Name: placebo control; Assigned to Arm(s): placebo | Intervention Type: BIOLOGICAL; Name: Influenza Virus Vaccine Live, Intranasal; Assigned to Arm(s): placebo, treatment
C: Arm Label: GSK1562902A non-AD F1 Primed Group; Type: EXPERIMENTAL; Interventions: Biological: Pandemic influenza candidate vaccine (GSK1562902A) - 2 doses | Arm Label: GSK1562902A non-AD F2 Primed Group; Type: EXPERIMENTAL; Interventions: Biological: Pandemic influenza candidate vaccine (GSK1562902A) - 2 doses | Arm Label: GSK1562902A non-AD F3 Primed Group; Type: EXPERIMENTAL; Interventions: Biological: Pandemic influenza candidate vaccine (GSK1562902A) - 2 doses | Arm Label: GSK1562902A non-AD F4 Primed Group; Type: EXPERIMENTAL; Interventions: Biological: Pandemic influenza candidate vaccine (GSK1562902A) - 2 doses | Arm Label: GSK1562902A AD F1 Primed Group; Type: EXPERIMENTAL; Interventions: Biological: Pandemic influenza candidate vaccine (GSK1562902A) - 1 dose | Arm Label: GSK1562902A AD F2 Primed Group; Type: EXPERIMENTAL; Interventions: Biological: Pandemic influenza candidate vaccine (GSK1562902A) - 1 dose | Arm Label: GSK1562902A AD F3 Primed Group; Type: EXPERIMENTAL; Interventions: Biological: Pandemic influenza candidate vaccine (GSK1562902A) - 1 dose | Arm Label: GSK1562902A AD Approved F4 Primed Group; Type: EXPERIMENTAL; Interventions: Biological: Pandemic influenza candidate vaccine (GSK1562902A) - 1 dose | Arm Label: Control Group; Type: EXPERIMENTAL; Interventions: Biological: Pandemic influenza candidate vaccine (GSK1562902A) - 2 doses | Intervention Type: BIOLOGICAL; Name: Pandemic influenza candidate vaccine (GSK1562902A) - 1 dose; Assigned to Arm(s): GSK1562902A AD Approved F4 Primed Group, GSK1562902A AD F1 Primed Group, GSK1562902A AD F2 Primed Group, GSK1562902A AD F3 Primed Group | Intervention Type: BIOLOGICAL; Name: Pandemic influenza candidate vaccine (GSK1562902A) - 2 doses; Assigned to Arm(s): Control Group, GSK1562902A non-AD F1 Primed Group, GSK1562902A non-AD F2 Primed Group, GSK1562902A non-AD F3 Primed Group, GSK1562902A non-AD F4 Primed Group
D: Arm Label: Group 2; Type: EXPERIMENTAL; Interventions: Biological: Influenza vaccine (FLU-v) | Arm Label: Group 3; Type: EXPERIMENTAL; Interventions: Biological: Influenza vaccine (FLU-v) | Arm Label: Group 4; Type: EXPERIMENTAL; Interventions: Biological: Influenza vaccine (FLU-v) | Arm Label: Group 1; Type: EXPERIMENTAL; Interventions: Biological: Influenza vaccine (FLU-v) | Arm Label: Control Group; Type: PLACEBO_COMPARATOR; Interventions: Biological: FLU-v Control | Intervention Type: BIOLOGICAL; Name: Influenza vaccine (FLU-v); Assigned to Arm(s): Group 1, Group 2, Group 3, Group 4 | Intervention Type: BIOLOGICAL; Name: FLU-v Control; Assigned to Arm(s): Control Group

Answer: B