Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Subjects Assessed to be at Imminent Risk for Suicide
Brief Summary: The purpose of the study is to evaluate the efficacy of intranasal esketamine 84 milligram (mg) compared with intranasal placebo in addition to comprehensive standard of care in reducing the symptoms of Major Depressive Disorder (MDD), including suicidal ideation, in participants who are assessed to be at imminent risk for suicide, as measured by the change from baseline on the Montgomery-Asberg Depression Rating Scale (MADRS) total score at 24 hours post first dose.


Options:
A: Arm Label: Intranasal Esketamine plus oral antidepressant; Type: EXPERIMENTAL; Interventions: Drug: Esketamine, Drug: Duloxetine (Oral Antidepressant), Drug: Escitalopram (Oral antidepressant), Drug: Sertraline (Oral Antidepressant), Drug: Venlafaxine Extended Release (XR) (Oral Antidepressant) | Arm Label: Placebo plus oral antidepressant; Type: ACTIVE_COMPARATOR; Interventions: Drug: Placebo, Drug: Duloxetine (Oral Antidepressant), Drug: Escitalopram (Oral antidepressant), Drug: Sertraline (Oral Antidepressant), Drug: Venlafaxine Extended Release (XR) (Oral Antidepressant) | Intervention Type: DRUG; Name: Esketamine; Assigned to Arm(s): Intranasal Esketamine plus oral antidepressant | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo plus oral antidepressant | Intervention Type: DRUG; Name: Duloxetine (Oral Antidepressant); Assigned to Arm(s): Intranasal Esketamine plus oral antidepressant, Placebo plus oral antidepressant | Intervention Type: DRUG; Name: Escitalopram (Oral antidepressant); Assigned to Arm(s): Intranasal Esketamine plus oral antidepressant, Placebo plus oral antidepressant | Intervention Type: DRUG; Name: Sertraline (Oral Antidepressant); Assigned to Arm(s): Intranasal Esketamine plus oral antidepressant, Placebo plus oral antidepressant | Intervention Type: DRUG; Name: Venlafaxine Extended Release (XR) (Oral Antidepressant); Assigned to Arm(s): Intranasal Esketamine plus oral antidepressant, Placebo plus oral antidepressant
B: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: D-cycloserine | Intervention Type: DRUG; Name: D-cycloserine; Assigned to Arm(s): 1
C: Arm Label: Esketamine + Standard of care; Type: EXPERIMENTAL; Interventions: Drug: Esketamine, Other: Standard of Care | Arm Label: Placebo + Standard of care; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo, Other: Standard of Care | Intervention Type: DRUG; Name: Esketamine; Assigned to Arm(s): Esketamine + Standard of care | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo + Standard of care | Intervention Type: OTHER; Name: Standard of Care; Assigned to Arm(s): Esketamine + Standard of care, Placebo + Standard of care
D: Arm Label: Esketamine low dose; Type: EXPERIMENTAL; Interventions: Drug: Esketamine DPI - low dose | Arm Label: Esketamine medium dose; Type: EXPERIMENTAL; Interventions: Drug: Esketamine DPI - medium dose | Arm Label: Esketamine high dose; Type: EXPERIMENTAL; Interventions: Drug: Esketamine DPI - high dose | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo DPI | Intervention Type: DRUG; Name: Esketamine DPI - low dose; Assigned to Arm(s): Esketamine low dose | Intervention Type: DRUG; Name: Esketamine DPI - medium dose; Assigned to Arm(s): Esketamine medium dose | Intervention Type: DRUG; Name: Esketamine DPI - high dose; Assigned to Arm(s): Esketamine high dose | Intervention Type: DRUG; Name: Placebo DPI; Assigned to Arm(s): Placebo

Answer: C