Please select the eligibility criteria that correspond to the clinical trial below.
Title: Examining the Efficacy of a SystemCHANGE™ Weight Management Intervention in Stroke Survivors and Persons With Chronic Inflammatory Autoimmune/Immune-mediated Diseases
Brief Summary: The objective of this study is to conduct a randomized controlled pilot study to examine the efficacy, feasibility and safety of the SystemCHANGE™(SC) health promotion and wellness program in adults with disabling conditions. Particularly, the study will focus on developing a program of research on adapting and testing SC weight management interventions in overweight and obese stroke survivors and persons with chronic inflammatory autoimmune/immune-mediated diseases, specifically those with multiple sclerosis (MS) and rheumatoid arthritis (RA).


Options:
A: Inclusion Criteria:

* Participation in a cardiovascular risk screening program
* 2 or more modifiable risk factors not on target:
* SBP \> 140 mmHg
* LDL-c \> 2.5 mmol/l
* Triglycerides \> 1.7 mmol/l
* BMI \> 25 kg/m2
* Diabetes Mellitus or fasting glucose \> 6.1 mmol/l
* Smoking

Exclusion Criteria:

* No internet access at home
* Unable to read and write Dutch
* Dependent in in daily activities (Ranking score \>=3)
* Life expectancy \< 2 years or an active malignant disease
B: Inclusion Criteria:

* A stroke specialist-determined ischemic stroke or TIA within the past year (including ocular strokes/TIA such as amaurosis fugax).
* Presence of systemic hypertension (average systolic blood pressure over two visits - i.e., SPC visit and study screening visit- exceeding 140 mmHg) OR fasting LDL cholesterol exceeding 2.0 mmol/L OR total: HDL cholesterol ratio exceeding 4.0 at SPC visit.

Exclusion Criteria:

* Neurological event considered to be due to intracranial hemorrhage (e.g., ICH, SAH), or trauma induced, or related to structural heart disease such as ASD/VSD or endocarditis.
* Foreshortened life-expectancy (e.g., active malignancy), hypertensive crisis (clinic systolic BP \> 200 mm Hg), or severe comorbidities.
* Institutionalized in a long-term care facility.
* Cognitive impairment (defined as a score of \> 5 on the Short Portable Mental Status questionnaire).
* Already on maximal therapy for risk factors (on 3 antihypertensive drugs at maximal dose if hypertension is inclusion criterion or on maximal dose statin if hyperlipidemia is inclusion criterion).
C: Inclusion Criteria Stroke:

* Physician-confirmed diagnosis of stroke (\> 6 weeks)
* Body mass index between 23 to 45 kg/m2
* Age 30 to 75 years

Exclusion Criteria Stroke:

* Pregnant or plans to become pregnant in the next 6 months
* Current participation in a face-to-face weight management program
* Uncontrolled diabetes (hospitalization within the prior 6 months)
* Serious mental illness
* Thyroid and adrenal gland diseases
* Inability to walk 3 meters with or without a cane or walker
* Severe cardiopulmonary disease that limits engagement in physical activity (e.g., myocardial infarction, congestive heart failure, coronary artery bypass grafting or valve replacement during the past three months, serious cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, and pulmonary embolus) or abnormal blood pressure or heart rate response after the 6-Minute Walking Test (e.g., a drop in systolic blood pressure of \>10mmHg from baseline)
* Severe cognitive deficits (Screening questioanire called the Short Orientation Memory-Concentration \< 12)
* Currently taking oral corticosteroids, antipsychotic (except for depression medication), or medications specifically for weight loss
* 3 or more falls in the past month
* Bulimia
* Unable to speak English over the phone
* Able to eat independently and is not on a special diet because of difficulty in swallowing
* Unstable weight (gained or lost \>10lbs in the last two months)

Inclusion Criteria MS or RA:

* Physician-confirmed diagnosis of multiple sclerosis or rheumatoid arthritis
* Body mass index between 23 to 45 kg/m2

Exclusion Criteria MS or RA:

* Pregnant or plans to become pregnant in the next 6 months
* Current participation in a face-to-face weight management program
* Uncontrolled diabetes (hospitalization within the prior 6 months)
* Serious mental illness
* Inability to walk 3 meters with or without a cane or walker
* Severe cardiopulmonary disease that limits engagement in physical activity
* Severe cognitive deficits (Short Orientation Memory-Concentration \< 12)
* Currently taking oral corticosteroids, antipsychotic (except for depression medication), or medications specifically for weight loss
* 3 or more falls in the past month
* Bulimia
* Unable to speak English
* Uncontrolled thyroid or adrenal disease (change in type and dosage of medication within the prior 3 months)
D: Inclusion Criteria:

* Age 30 years and above
* Personal history of heart attack or stroke
* Presence of other cardiovascular risk factors such as smoking, overweight, diabetes

Exclusion Criteria:

* Mental disability
* Not living in the Study area

Answer: C