Please select the eligibility criteria that correspond to the clinical trial below.
Title: Alcohol and Atherosclerosis Pilot Study
Brief Summary: We propose a pilot study to determine the feasibility of a long-term clinical trial of alcohol intake on atherosclerosis, the first step in determining whether moderate drinking prevents cardiovascular disease and hence in understanding the full health effects of alcohol across the population. We will randomize 40 participants aged 55 and older to a six-month period of consumption of 1 glass per day of either pure alcohol (diluted to the strength of wine) or water. At baseline and after 6 months, we will measure several standard and novel cardiovascular risk markers in the blood and will perform magnetic resonance imaging to measure atherosclerosis of the aorta.


Options:
A: Inclusion Criteria:

* In- and outpatients of the Neurology Department of the CHL and their family members
* Carotid atherosclerosis assessed by B-mode ultrasound of at least 20% lumen reduction
* No acute stroke/TIA/amaurosis fugax (at least 3 months ago)
* Temporal ultrasound window suitable for recording of the middle cerebral artery
* Ability to give informed consent

Exclusion Criteria:

* No signed informed consent
* patient not able to give informed consent
B: Inclusion Criteria:

* Reside in Seoul
* Who provided Informed consent

Exclusion Criteria:

* Who has cancer
* Who has disease or disorder of liver, nervous system, endocrine system, cardiovascular system
* Who does not provieded informed consent
C: Inclusion Criteria:

* Diabetes
* Current Smoking
* Hypertension
* Family history of heart disease
* High LDL Cholesterol (\>130 mg/dl)
* Low HDL CHolesterol (\<40 mg/dl)
* Body Mass Index of 30 kg/m\^2
* Waist circumference greater than 40 inches for men and 35 inches for women
* Report intake of at least one drink in the last month
* Post-menopause (if woman)

Exclusion Criteria:

* History of myocardial infarction (MI)/ heart attack within prior 6 months.
* Revascularization procedure (coronary, carotid, or peripheral)
* Stroke
* Claustrophobia
* Intolerance to previous MRI examinations
* Standard MRI contraindications (e.g. pacemaker, intra-auricular implants, or intracranial clips)
* Weight over 350 pounds
* Active atrial fibrillation
* Reports intake of more than 7 drinks per week currently, has previous or current history of alcohol abuse based on standard questionnaires, or who has consumed more than 4 drinks in one day within the last 6 months.
* Intolerance or allergy to alcohol consumption (includes flushing)
* Allergy to aspartame, acesulfame, or artificial food coloring
* Any severe illness expected to cause death or profound disability within 6 months
* Evidence of depression (as measured based on a Center for Epidemiological Studies Depression score of 16 or higher)
* History of chronic liver disease
* Personal history of breast or any gastrointestinal cancer, uncontrolled hypertension (blood pressure greater than or equal to 180/110)
* Chronic renal failure on dialysis
* Current use of Metronidazole or Warfarin
* Use of benzodiazepines, barbiturates, and related sedative/ hypnotics 4 or more days per week.
* Severe psychiatric illness
* Inability to speak English
* Lack of a working telephone
D: Inclusion Criteria:

1. Age between 40-75 yrs.
2. Alcohol abstainers (less than or equal to 1 drink/week)
3. Established diagnosis of type 2 diabetes.
4. Clinically stable, with no stroke or MI within the last 3 months and no major surgery within the last 3 months.

Exclusion Criteria:

1. Taking Insulin \>2 injections /day, or with insulin pump.
2. TGs\>500 mg/dL.
3. HbA1c \>10%
4. Serum creatinine \> 2 mg/dl
5. Liver dysfunction (above 2 fold level of ALT and/or AST enzymes)

5. Evidence of severe diabetes complications (such as proliferative retinopathy or renal disease).

6. Patients with autonomic neuropathy manifested as postural hypertension and/or hypoglycemia unawareness. 7. Using drugs that might significantly interact with moderate alcohol. List of drugs will be obtained from pharmacology expert. 8. Presence of active cancer, receiving or had received chemotherapy in last 3 years.

9. Suffering a major illness that might probably require hospitalization (upon physician's evaluation).

10. Clinically assessed as having high potential of addictive behavior as judged by a validated clinical assessment and/or personal or family history of addiction, alcoholism or alcohol abuse.

11. Severe symptoms during run-in as assessed by the physician. 12. Pregnant or lactating women. 13. Participation in another trial in which active intervention is being received.

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Answer: C