Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Clinical Trial of Oral Phenylbutyrate and Vitamin D Adjunctive Therapy in Pulmonary Tuberculosis in Bangladesh: a Pilot Study
Brief Summary: Vitamin D exerts its effects via the Vitamin D Receptor (VDR) present in activated macrophages and induces expression and release of the cathelicidin, LL-37, a human antimicrobial peptide involved in killing of MTB. We aimed to investigate whether treatment of newly diagnosed pulmonary TB patients for 2 months with adjunctive PBA and vitamin D (Cholecalciferol) in combination with standard DOTS therapy (i) can improve response to standard short course TB therapy towards a rapid recovery; (ii) can induce expression of LL-37 in macrophages; (iii) can enhance killing capacity of macrophages isolated from TB patients infected in vitro with MTB; and (iv) does not evoke any adverse effects.


Options:
A: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Arm Label: Multivitamins; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Multivitamins | Intervention Type: DIETARY_SUPPLEMENT; Name: Multivitamins; Assigned to Arm(s): Multivitamins | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo
B: Arm Label: Active Sodium Phenylbutyrate and active cholecalciferol; Type: ACTIVE_COMPARATOR; Interventions: Drug: Active Sodium Phenylbutyrate and active cholecalciferol | Arm Label: Placebo Sodium Phenylbutyrate plus active cholecalciferol; Type: ACTIVE_COMPARATOR; Interventions: Drug: Placebo Sodium Phenylbutyrate plus active cholecalciferol | Arm Label: Active Sodium Phenylbutyrate and placebo cholecalciferol; Type: ACTIVE_COMPARATOR; Interventions: Drug: Active Sodium Phenylbutyrate and placebo cholecalciferol | Arm Label: Placebo Sodium Phenylbutyrate plus placebo cholecalciferol; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo Sodium Phenylbutyrate plus placebo cholecalciferol | Intervention Type: DRUG; Name: Active Sodium Phenylbutyrate and active cholecalciferol; Assigned to Arm(s): Active Sodium Phenylbutyrate and active cholecalciferol | Intervention Type: DRUG; Name: Placebo Sodium Phenylbutyrate plus active cholecalciferol; Assigned to Arm(s): Placebo Sodium Phenylbutyrate plus active cholecalciferol | Intervention Type: DRUG; Name: Active Sodium Phenylbutyrate and placebo cholecalciferol; Assigned to Arm(s): Active Sodium Phenylbutyrate and placebo cholecalciferol | Intervention Type: DRUG; Name: Placebo Sodium Phenylbutyrate plus placebo cholecalciferol; Assigned to Arm(s): Placebo Sodium Phenylbutyrate plus placebo cholecalciferol
C: Arm Label: Vitamin D pill; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Vitamin D pill | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: Vitamin D pill; Assigned to Arm(s): Vitamin D pill | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo; Assigned to Arm(s): Placebo
D: Arm Label: Study drug containing zinc alone; Type: EXPERIMENTAL; Interventions: Drug: Zinc | Arm Label: Study drug Micronutrient without zinc; Type: EXPERIMENTAL; Interventions: Drug: Micronutrient without zinc | Arm Label: Study drug Micronutrient with zinc; Type: EXPERIMENTAL; Interventions: Drug: Micronutrient with zinc | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Zinc; Assigned to Arm(s): Study drug containing zinc alone | Intervention Type: DRUG; Name: Micronutrient without zinc; Assigned to Arm(s): Study drug Micronutrient without zinc | Intervention Type: DRUG; Name: Micronutrient with zinc; Assigned to Arm(s): Study drug Micronutrient with zinc | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo

Answer: B