Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized Phase III Trial of Memantine and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Patients With Brain Metastases
Brief Summary: This randomized phase III trial compares memantine hydrochloride and whole-brain radiotherapy with or without hippocampal avoidance in reducing neurocognitive decline in patients with cancer that has spread from the primary site (place where it started) to the brain. Whole brain radiotherapy (WBRT) is the most common treatment for brain metastasis. Unfortunately, the majority of patients with brain metastases experience cognitive (such as learning and memory) deterioration after WBRT. Memantine hydrochloride may enhance cognitive function by binding to and inhibiting channels of receptors located in the central nervous system. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Using radiation techniques, such as intensity modulated radiotherapy to avoid the hippocampal region during WBRT, may reduce the radiation dose to the hippocampus and help limit the radiation-induced cognitive decline. It is not yet known whether giving memantine hydrochloride and WBRT with or without hippocampal avoidance works better in reducing neurocognitive decline in patients with brain metastases.


Options:
A: Arm Label: ketogenic diet and transient fasting; Type: EXPERIMENTAL; Interventions: Dietary Supplement: calorie-restricted ketogenic diet and transient fasting | Arm Label: standard nutrition; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: standard nutrition | Intervention Type: DIETARY_SUPPLEMENT; Name: calorie-restricted ketogenic diet and transient fasting; Assigned to Arm(s): ketogenic diet and transient fasting | Intervention Type: DIETARY_SUPPLEMENT; Name: standard nutrition; Assigned to Arm(s): standard nutrition
B: Arm Label: WBRT with Hippocampal Avoidance; Type: OTHER; Interventions: Radiation: intensity-modulated radiation therapy | Intervention Type: RADIATION; Name: intensity-modulated radiation therapy; Assigned to Arm(s): WBRT with Hippocampal Avoidance
C: Arm Label: Whole Brain Radiation Therapy; Type: EXPERIMENTAL; Interventions: Procedure: Whole Brain Radiation Therapy, Behavioral: Questionnaire | Arm Label: Observation; Type: OTHER; Interventions: Other: Observation, Behavioral: Questionnaire | Intervention Type: PROCEDURE; Name: Whole Brain Radiation Therapy; Assigned to Arm(s): Whole Brain Radiation Therapy | Intervention Type: OTHER; Name: Observation; Assigned to Arm(s): Observation | Intervention Type: BEHAVIORAL; Name: Questionnaire; Assigned to Arm(s): Observation, Whole Brain Radiation Therapy
D: Arm Label: WBRT + Memantine; Type: EXPERIMENTAL; Interventions: Drug: Memantine, Radiation: Whole brain radiation therapy | Arm Label: HA-WBRT/IMRT+ Memantine; Type: EXPERIMENTAL; Interventions: Radiation: Whole brain radiation therapy with hippocampal avoidance, Drug: Memantine | Intervention Type: RADIATION; Name: Whole brain radiation therapy with hippocampal avoidance; Assigned to Arm(s): HA-WBRT/IMRT+ Memantine | Intervention Type: DRUG; Name: Memantine; Assigned to Arm(s): HA-WBRT/IMRT+ Memantine, WBRT + Memantine | Intervention Type: RADIATION; Name: Whole brain radiation therapy; Assigned to Arm(s): WBRT + Memantine

Answer: D