Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: The Artificial Kidney Initiation in Kidney Injury 2 A Multi-Centre, Randomized, Controlled Trial
Brief Summary: The timing of renal replacement therapy (RRT) in the context of severe acute kidney injury (AKI) is one the most debated issues in critical care medicine. The Artificial Kidney Initiation in Kidney Injury (AKIKI) was the first large prospective multicenter randomized trial published on this topic. This study (published in the New England Journal of Medicine, July 2017) showed no significant difference between an early and delayed RRT initiation strategy in term of mortality. Nearly 50% of patients escaped RRT in the delayed strategy and this strategy was associated with less catheter-related infections and faster renal function recovery. Two (serum urea concentration \>40 mmol/l and oliguria/anuria for more than 72 hours) of the 5 criteria which mandated RRT in the delayed strategy are still open to debate since they have never been shown to put patient at danger. To go further into our investigation of RRT criteria, the investigators designed a study that would compare the "delayed strategy" used in AKIKI that can now be considered as "standard" with another in which RRT is delayed for a longer period in the absence of a life-threatening complication (such as hyperkalemia or severe overload pulmonary edema).


Options:
A: Arm Label: Standard strategy; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Standard strategy | Arm Label: Delayed strategy; Type: EXPERIMENTAL; Interventions: Procedure: Delayed strategy | Intervention Type: PROCEDURE; Name: Standard strategy; Assigned to Arm(s): Standard strategy | Intervention Type: PROCEDURE; Name: Delayed strategy; Assigned to Arm(s): Delayed strategy
B: Arm Label: high volume hemofiltration; Type: EXPERIMENTAL; Interventions: Procedure: high volume hemofiltration | Arm Label: standard care; Type: ACTIVE_COMPARATOR; Interventions: Procedure: standard care | Intervention Type: PROCEDURE; Name: high volume hemofiltration; Assigned to Arm(s): high volume hemofiltration | Intervention Type: PROCEDURE; Name: standard care; Assigned to Arm(s): standard care
C: Arm Label: Early renal replacement therapy; Type: EXPERIMENTAL; Interventions: Device: Dialysis with continuous renal replacement therapy, Device: Mechanical ventilator, Drug: Anti-Bacterial Agents, Drug: Vasopressors | Arm Label: Conventional renal replacement therapy; Type: PLACEBO_COMPARATOR; Interventions: Device: Dialysis with continuous renal replacement therapy, Device: Mechanical ventilator, Drug: Anti-Bacterial Agents, Drug: Vasopressors | Intervention Type: DEVICE; Name: Dialysis with continuous renal replacement therapy; Assigned to Arm(s): Conventional renal replacement therapy, Early renal replacement therapy | Intervention Type: DEVICE; Name: Mechanical ventilator; Assigned to Arm(s): Conventional renal replacement therapy, Early renal replacement therapy | Intervention Type: DRUG; Name: Anti-Bacterial Agents; Assigned to Arm(s): Conventional renal replacement therapy, Early renal replacement therapy | Intervention Type: DRUG; Name: Vasopressors; Assigned to Arm(s): Conventional renal replacement therapy, Early renal replacement therapy
D: Arm Label: Standard RRT initiation; Type: ACTIVE_COMPARATOR; Interventions: Other: Standard RRT initiation | Arm Label: Accelerated RRT initiation; Type: EXPERIMENTAL; Interventions: Other: Accelerated RRT initiation | Intervention Type: OTHER; Name: Accelerated RRT initiation; Assigned to Arm(s): Accelerated RRT initiation | Intervention Type: OTHER; Name: Standard RRT initiation; Assigned to Arm(s): Standard RRT initiation

Answer: A