Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Randomized, Open, Parallel, Multi-center Trial to Evaluate Weight Loss Efficacy of Smart Care Service in Obese Patients With Metabolic Syndrome.
Brief Summary: A randomized, open, parallel, multi-center trial to evaluate weight loss efficacy of Smart Care Service in obese patients with metabolic syndrome.


Options:
A: Inclusion Criteria:

* primary care patient at UCLA Family Health Center or 16th Street Internal Medicine
* age 18 or older,
* English speaking,
* BMI \> 25,
* interested in losing weight,
* smartphone ownership,
* valid email address.

Exclusion Criteria:

* current, planned or previous pregnancy within 6 months,
* currently using a smartphone app for dieting,
* hemodialysis,
* terminal illness
B: Inclusion Criteria:

1. Age: More than 20 years of age and under 70 years of age.
2. BMI ≥ 25kg/m2
3. Patients with metabolic syndrome (who have more than three of following 5 components of metabolic syndrome) and who are able to receive outpatient treatment.

   A. Abdominal obesity: Waist circumference≥90cm(Male), 85cm(Female) B. Patients whose blood pressure ≥130/85mmHg(systolic blood pressure over 130 or, diastolic blood pressure over 85) or patients who are taking blood pressure medication.

   C. Fasting Blood Glucose (FPG)≥ 100mg/dl. D. Patients whose triglyceride ≥150 mg/dl or patients who are taking fibrate. E. High-density lipoprotein cholesterol (HDL) \< 40 mg/dl (Male), 50 mg/dl(Female)
4. Patients who are able to understand the purpose of this trial and to read and write.
5. Patients who are able to use U-healthcare Smartphone for this trial.
6. Patients who participate voluntarily and sign the informed consent.

Exclusion Criteria:

1. Type I diabetes mellitus patients and type II diabetes mellitus patients requiring insulin therapy.
2. Patients currently being hospitalized or planning to hospitalize during the study period.
3. Patients were diagnosed with myocardial infarction or stroke within 1 year
4. End Stage Renal Disease patients requiring renal replacement therapy, Serum creatinine level is greater than 1.5 times the upper limit of normal.
5. Females who are pregnant
6. Hepatic failure (severe hepatic dysfunction). Liver Function Test (AST or ALT) is greater than 3 times the upper limit of normal.
7. Uncontrolled chronic lung disease.
8. Patients with known gallstone.
9. Patients who have cognitive disorder or psychiatric problems.
10. Patients who are taking anti-obesity medications such as Reductil, Xenical, etc., or patients are planning to receive the medications.
11. Patients who are taking Synthroid, diabetes medications or psychiatric medications which may affect on body weight.
12. Any clinically significant medical condition including neurologic disease, gastrointestinal disease or malignant tumor, etc., which may affect the test results, or any other medical condition which in the opinion of the investigator makes the patients unsuitable for participation in the trial.
13. Patients who have participated in other clinical trial (except for the observational study) within 12 weeks prior to screening visit.
C: Inclusion Criteria:

* Obese subjects (IMC ≥ 27.5 to \<40), classified as sedentary according to the short physical activity questionnaire validated in the EVIDENT II study.

Exclusion Criteria:

* Older than 65 years are excluded, due to difficulties in the use of ICTs.
* Advanced respiratory, renal or liver disease.
* Several mental illness
* Coronary or cerebrovascular atherosclerotic disease, grade II or higher NYHA heart failure.
* Moderate or severe COPD
* Muscular-skeletal pathology that inhibit mobility
* Subjects who can not exercise or follow a hypocaloric diet.
* Oncologic disease in treatment diagnosed in the last 5 years.
* Terminal situation
* Pregnancy
* Bariatric surgery
* Those with any other circumstance that the investigators consider could interfere with the study procedures
D: Inclusion Criteria:

* Having a IMC \>25,
* Being sedentary and
* Have not been submitted to a restrictive diet in the 6 months preceding this study.
* Having a body fat percentage of ≥ 30%

Exclusion Criteria:

* Suffered from type 2 diabetes or renal conditions
* Being pregnancy or attempt at pregnancy,
* Being in a maternal lactation period,
* Not possessing a Smartphone with an operating system (Android or iOS) and available data connection did not participate in the study.

Answer: B