Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Effects of Strattera and Behavior Therapy on the School and Home Functioning of Elementary School Children With Attention-Deficit/Hyperactivity Disorder (ADHD)
Brief Summary: Background: Multiple studies have found Atomoxetine (Strattera) to be efficacious but there is only one published study specifically designed to evaluate its efficacy in school settings. In this 7 week placebo-controlled study, Atomoxetine (ATX) at mean dose of 1.3 mg/kg, significantly reduced teacher rated ADHD symptoms (Weiss et al., 2005). However, children are typically referred for treatment because of "real life" problems in functioning, not symptoms (Pelham, Fabiano, \& Massetti, 2005). While ATX has been found to produce functional improvements at home, the Weiss study found limited results in this area at school.

Furthermore, almost no research has examined the effects of combining ATX and behavior therapy (BT). In the MTA, adding BT to stimulants improved teacher ratings of hyperactivity/impulsivity and increased the number of subjects reaching optimal response (Swanson et al., 2001). Therefore, it is possible that the addition of BT to ATX may improve functional performance in the classroom. The effects of combined therapy may be even larger for ATX as monotherapy with nonstimulants produces smaller effect sizes than with stimulants.

Objective: The primary objective was to evaluate the effects of ATX alone and in combination with BT on the school functioning of 56 children ages 6-12 with ADHD. Outcomes were assessed using traditional symptoms measures as well as functional measures of academic and behavioral improvements in the classroom.


Options:
A: Arm Label: Combined therapy; Type: EXPERIMENTAL; Interventions: Drug: atomoxetine, Behavioral: Behavior Modification Therapy | Arm Label: Drug therapy; Type: ACTIVE_COMPARATOR; Interventions: Drug: atomoxetine | Intervention Type: DRUG; Name: atomoxetine; Assigned to Arm(s): Combined therapy, Drug therapy | Intervention Type: BEHAVIORAL; Name: Behavior Modification Therapy; Assigned to Arm(s): Combined therapy
B: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Drug: Stimulant medication therapy, Behavioral: Community-based psychosocial treatment | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Behavioral: Group-based behavior therapy, Drug: Stimulant medication therapy | Intervention Type: BEHAVIORAL; Name: Group-based behavior therapy; Assigned to Arm(s): 2 | Intervention Type: DRUG; Name: Stimulant medication therapy; Assigned to Arm(s): 1, 2 | Intervention Type: BEHAVIORAL; Name: Community-based psychosocial treatment; Assigned to Arm(s): 1
C: Arm Label: Executive function training; Type: EXPERIMENTAL; Interventions: Behavioral: A randomized controlled study of Executive Function training for children with ADHD | Intervention Type: BEHAVIORAL; Name: A randomized controlled study of Executive Function training for children with ADHD; Assigned to Arm(s): Executive function training
D: Arm Label: Social sk. tr., parent tr.,standard tr.; Type: EXPERIMENTAL; Interventions: Behavioral: Social skills training, parental tr. and standard tr. | Arm Label: Standard treatment; Type: ACTIVE_COMPARATOR; Interventions: Other: Standard treatment | Intervention Type: BEHAVIORAL; Name: Social skills training, parental tr. and standard tr.; Assigned to Arm(s): Social sk. tr., parent tr.,standard tr. | Intervention Type: OTHER; Name: Standard treatment; Assigned to Arm(s): Standard treatment

Answer: A