TrialPanorama/Dataset huggingface dataset:
Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Pulmaquin® in the Management of Chronic Lung Infections With Pseudomonas Aeruginosa in Subjects With Non-Cystic Fibrosis Bronchiectasis, Including 28 Day Open-Label Extension and Pharmacokinetic Substudy (ORBIT-3)
Brief Summary: This study (ARD-3150-1201, ORBIT-3) will evaluate the safety and efficacy of inhaled Pulmaquin (ciprofloxacin dispersion for inhalation) compared to inhaled placebo in subjects who have a confirmed diagnosis of non-cystic fibrosis (non-CF) bronchiectasis with a history of pulmonary exacerbations and chronic P. aeruginosa infections.


Options:
A: Inclusion Criteria:

* Verified bronchiectasis diagnosis
* Pseudomonas aeruginosa lung infection

Exclusion Criteria:

* Cystic Fibrosis
B: Inclusion Criteria:

* Male/Female 18 years or older with non-CF bronchiectasis
* Chronic sputum production on most days
* Positive sputum culture for gram-negative organisms
* Must have met lung function requirements

Exclusion Criteria:

* History of CF
* Hospitalized within 14 days prior to joining the study
* Previous exposure to AZLI
* Pregnant, breastfeeding, or unwilling to follow contraceptive measures for the study
* Must have met liver and kidney function requirements
* Continuous oxygen use of greater than 2 liters per minute (supplemental oxygen with activity and at night was allowed)
* Treatment for nontuberculous mycobacteria infection or active mycobacterium tuberculosis infection within 1 year of enrollment
* Other serious medical conditions.
C: Inclusion Criteria:

* Confirmed diagnosis of non-CF bronchiectasis
* History of P. aeruginosa respiratory infections
* At least two pulmonary exacerbations treated with antibiotics in the previous year

Exclusion Criteria:

* Have a clinical diagnosis of CF
* Are pregnant
D: Inclusion Criteria:

* Male/Female 18 years or older with non-CF bronchiectasis
* Chronic sputum production on most days
* Positive sputum culture for gram-negative organisms
* Must have met lung function requirements

Exclusion Criteria:

* History of CF
* Hospitalized within 14 days prior to joining the study
* Previous exposure to AZLI
* Pregnant, breastfeeding, or unwilling to follow contraceptive measures for the study
* Must have met liver and kidney function requirements
* Continuous oxygen use of greater than 2 liters per minute (supplemental oxygen with activity and at night was allowed)
* Treatment for nontuberculous mycobacteria infection or active mycobacterium tuberculosis infection within 1 year of enrollment
* Other serious medical conditions.

Answer: A
Please select the eligibility criteria that correspond to the clinical trial below.
Title: N/A
Brief Summary: The investigators hypothesize that a three-month aerobic exercise training program will positively affect the lipid profile, insulin sensitivity , cytokine profile, the cardiovascular parameters and muscle strength in SLE patients.


Options:
A: Inclusion Criteria:

* Positive ANA-titer (≥ 1:80) or Anti-dsDNA (≥ 200 IU/ml) or Highly avid-dsDNA autoantibody (≥ 30 IU/ml)
* Stable immunosuppressive therapy more than 30 days before beginning of the study with steroid (0-20 mg/day) or other immunosuppressive medication like Hydroxchloroquin, Chloroquin, Azathioprin, Methotrexat, Mycophenolatmofetil, Cyclosporin, Belimumab, Rituximab

Exclusion Criteria:

* Pregnancy, Active lupus nephritits, Physical activity more than two times a week
B: Inclusion Criteria:

* female systemic lupus erythematosus patients
* 18 to 45 years of age
* Fulfilled at least four criteria classification for lupus (ACR criteria, 1997) - Signed the consent form approved by the ethics committee of the institution

Exclusion Criteria:

* Hemoglobin \< 10 mg/dL
* Neuropsychiatric, pulmonary, articular or vascular damage that would prevent the practice of exercise
* Coronary disease or heart failure, functional class ≥ II
* Pulmonary hypertension
* Uncontrolled hypertension
* Creatinine ≥ 1.4 mg/dL
* Body mass index (BMI) ≥ 35 kg/m2
* Diabetes mellitus
* Uncontrolled hypothyroidism
* Smoking in the last 12 months
* Pregnancy
* Menopause
* Use of statins in the last three months
* Practice of physical exercise in past three months
* Overlap with other autoimmune rheumatic diseases, except antiphospholipid syndrome.
C: Inclusion Criteria:

- Inflammatory rheumatic disease

Exclusion Criteria:

* Inability to complete the testing procedures
* Pregancy
* Not able to perform exercise intervention
* Planed surgeries or other plans during initial exercise intervention period than directly will effect the testing or training.
* Access to a smartphone
* Less than 80% compliance of planned training sessions
D: Inclusion Criteria:

* Age between 7 and 40 years
* SLEDAI ≤ 4

Exclusion Criteria:

* Cardiovascular dysfunction
* Rhythm and conduction disorders
* Musculoskeletal disturbances
* Kidney and pulmonary involvements
* Peripheral neuropathy
* Use of tobacco
* Treatment with lipid-lowering or hypoglycemic drugs
* Fibromyalgia
* Use of chronotropic or antihypertensive drugs
* Physically active subjects

Answer: D
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Promoting Healthy Lifestyles Using Mobile Phones
Brief Summary: The purpose of this research is to test programs to increase physical activity and reduce sedentary behavior using motivational messages over a cell phone.


Options:
A: Inclusion Criteria:

1. Have chronic low back pain defined as a back pain problem that has persisted at least 3 months and has resulted in pain on at least half the days in the past 6 months
2. Oswestry low back pain index \>20% to ensure a moderate level of disability is present, thus minimizing a potential floor effect
3. Currently perform deskwork at least 20 hours per week at a desk compatible with the sit-stand attachment
4. Stable employment (at least 3 months at current job and plan to stay at current job for the next 6 months)
5. Ability to obtain approval to install sit-stand workstation (i.e., from supervisor)
6. Access to internet connection and email to complete assessment surveys

Exclusion Criteria:

1. Unable to provide informed consent
2. Cardiovascular event in the last 6 months (e.g. heart attack, stoke, heart failure, revascularization procedure)
3. Presence of a comorbid condition that would limit ability to reduce sedentary behavior (e.g. currently undergoing treatment for cancer)
4. Back surgery in the past 3 months or planned in the next year
5. Presence of a medical "red flag" for a serious spinal condition (cancer, compression fracture, signs or symptoms of root compression, infection)
6. Inability to tolerate standing for any reason
7. Currently using a sit-stand desk, standing desk, or wearable activity monitor
8. Currently pregnant or planned pregnancy in the next 6 months
9. Blood pressure \>159/100 mmHg
B: Inclusion Criteria:

* aged 45 and older, currently sedentary, owns and uses a cell phone but not a Smartphone, willing to be randomly assigned

Exclusion Criteria:

* free of clinically evident cardiovascular disease or any other medical condition or disorder that would limit participation in moderate intensity physical activities akin to brisk walking
C: Inclusion Criteria:

* Bariatric surgery patients and other obese individuals will be considered
* Body mass index \>= 30 kg/m2

Exclusion Criteria:

* Report being unable to engage in daily activities and walk continuously for \>= 10 minutes without assistance
* Are currently involved in a physical activity intervention.
* Are unable to read or understand the study materials
* Are currently taking medications that cause dizziness and/or feeling faint when sitting or standing.
* Report any condition that in the opinion of investigators would preclude adherence to the intervention protocol including plans to relocate, history of substance abuse or other significant psychiatric problems, or terminal illness.
D: Inclusion Criteria:

- 18 years old or older

Exclusion Criteria:

* Not Dutch-speaking
* Does not own a smartphone
* Does not have access to the internet
* Is not able to be physically active/non-sedentary

Answer: B
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Promoting Healthy Lifestyles Using Mobile Phones
Brief Summary: The purpose of this research is to test programs to increase physical activity and reduce sedentary behavior using motivational messages over a cell phone.


Options:
A: Inclusion Criteria:

* Over the age of 65
* Able to walk 20 meters independently (without human assistance, can use cane/walker)
* Able to speak and read in English
* No cognitive, vision or hearing impairments that would prevent provision of informed consent, comprehension of instructions, completion of surveys and participation in phone conversations
* Able to complete the Timed Up and Go Test to assess falls risk within 30 seconds
* Live within the selected retirement community (facility-dwelling) Able to hold brief conversation over the telephone.
* Will be in San Diego for the duration of the study
* Provision of consent to participate
* Willing to wear a pedometer, accelerometer and GPS device
* Willing to complete all surveys and attend weekly meetings
* No history of falls in previous that resulted in an injury or hospitalization in the past 12 months
* Physician clearance to participate

Exclusion Criteria:

* Inability to give informed, voluntary consent
* Inability to complete assessments
* Lack of written physician consent to participate in unsupervised light-to-moderate intensity walking
* Inability to speak and read English
B: Inclusion Criteria:

* Healthy adults
* Physically inactive in leisure time (assessed by self reported questionnaire)

Exclusion Criteria:

* Presence of serious heart problems or not being able to perform everyday activities
* Highly physically active in leisure time (assessed by self reported questionnaire)
C: Inclusion Criteria:

* Mobile phone user
* Acceptable health that does not prevent exercise
* Acceptable command of the English language
* No engagement in a regular- structured exercise routine like gym training or other structured programmes
* Interest in an exercise programme
* Willing to attend scheduled follow-up sessions at 12 weeks (pre-post evaluation) and 24 weeks (post-intervention evaluation) after the first session

Exclusion Criteria:

* participants who have any medical condition or health concern that would restrict regular exercise based on one screening question. If this question will be answered with "yes" participants are advised to seek medical care.
D: Inclusion Criteria:

* aged 45 and older, currently sedentary, owns and uses a cell phone but not a Smartphone, willing to be randomly assigned

Exclusion Criteria:

* free of clinically evident cardiovascular disease or any other medical condition or disorder that would limit participation in moderate intensity physical activities akin to brisk walking

Answer: D
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Can Mass Media Campaigns Reduce Child Mortality
Brief Summary: A cluster-randomised trial will be undertaken in Burkina Faso to investigate whether a comprehensive mass media campaign using local radio stations can change behaviours on a scale large enough to result in measurable and sustainable reductions in under-five child mortality.

It is hypothesised that as a result of the scale and multi-pronged nature of the campaign, reductions of between 10% and 20% in child mortality will be achieved.


Options:
A: Inclusion Criteria:

* at least one child 0-24 months (at baseline) lives in the household
* adult family member (mother of primary caregiver of the selected children for the study) consents to participate in the study and provides consent for the child's participation

Exclusion Criteria:

* none
B: Inclusion Criteria:

* Residence in study clusters

Exclusion Criteria:

* None
C: Inclusion Criteria:

(1) Infants (target child) will be eligible to participate in the study if they are:

1. They are in utero at the baseline survey
2. Their parents/guardians are planning to stay in the study village for the next 12 months (if a mother is planning to give birth at her natal home and then return, she will still be a candidate for enrollment)

(2) Children \< 36 months old at baseline that are living in the compound of a target child will be eligible to participate in diarrhea measurement if:

1. They are \< 36 months old at the baseline survey
2. Their parents/guardians are planning to stay in the study village for the next 12 months

(3) Children 18 - 27 months old at baseline that are living in the compound of a target child will be eligible to participate in intestinal parasite specimen collection if:

1. They are 18 - 27 months old at the baseline survey
2. Their parents/guardians are planning to stay in the study village for the next 12 months
D: Study participants will be women who are rural residents of Chirumanzu or Shurugwi districts in Zimbabwe and who become pregnant during the enrollment period of the trial and are identified and consent to participation during pregnancy, and their live born infants. A total of 5280 women will be enrolled.

Inclusion Criteria:

Pregnant women residing in the study districts, whose pregnancy is confirmed by a urine pregnancy test.

Exclusion Criteria:

* Women residing in the study districts who become pregnant during the enrollment period but do not consent to join the trial
* Women who reside in urban areas of these two districts
* Infants with major non-fatal abnormalities will not be excluded from study procedures, but will be excluded from the final analytic sample if the abnormality is likely to directly affect gut health/function or stature (e.g. neural tube defects, cerebral palsy, Down syndrome)

Answer: B
Please select the eligibility criteria that correspond to the clinical trial below.
Title: PETS-D (Parent Education Thru Simulation-Diabetes)
Brief Summary: Hypothesis: Parents who receive Parent Education Thru Simulation-Diabetes (PETS-D) will have significantly higher diabetes knowledge (cognitive visual schemata), better technical and problem-solving competence and confidence, and lower fear and stress/anxiety levels; and provide better diabetes management at 14 weeks compared to those parents receiving standard diabetes education.


Options:
A: Inclusion Criteria:

* between 11 and 18 years of age
* moderate to severe traumatic brain injury
* overnight hospital stay
* injury occurred within the last 12 months

Exclusion Criteria:

* younger than 11 and older than 18 years of age
* injury occurred more than 12 months ago
* teen does not live with parents or guardian
* English not spoken in the home
* injury is a result of child abuse as documented by medical record
* child or parent has history of hospitalization for a psychiatric problem
* documentation that the injury is a result of child abuse
* child suffered a non-blunt injury (e.g. projectile wounds, stroke, drowning, or other form of asphyxiation)
* child ever diagnosed with moderate or severe mental retardation, Autism, or a significant developmental disability (child must be able to talk)
* plans for the child to leave home during the coming 12 months.
B: Inclusion Criteria:

* parents 18 years and older who have a child newly diagnosed with type 1 diabetes mellitus (T1DM) from 5 years old to under 13 years of age

Exclusion Criteria:

* exclude children with developmental delays (such as Down Syndrome, Autism) or steroid induced diabetes (cancer treatment related or cystic fibrosis)
* exclude parents who require insulin treatment -or- those that have another child with TIDM
C: Inclusion Criteria:

* Moderate to severe TBI that occurred within the last 24 months
* Overnight hospital stay
* English-speaking
* Parent must be willing to provide informed consent

Exclusion Criteria:

* Child does not live with parents or guardian
* Child or parent has history of hospitalization for psychiatric problem
* Child suffered a non-blunt injury (e.g., projectile wound, stroke, drowning, or other form of asphyxiation)
* Diagnosed with moderate or severe mental retardation, autism, or a significant developmental disability
D: Inclusion Criteria:

* a current hemoglobin A1c(HbA1c) of \>8.0%
* an average HbA1c of \>8.0% during the past year
* diagnosed with Type 1 diabetes for at least one year
* reside in the metro Detroit tri-county area

Exclusion Criteria:

* severe mental impairment/thought disorder
* non-English speaking patient/parent
* co-morbid major medical condition such as cystic fibrosis

Answer: B
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Comparing Two Parenting Programs for At-Risk Families
Brief Summary: The purpose of this study is to compare the effectiveness of two parenting programs in a mental health clinic serving young children with behavior problems.


Options:
A: Inclusion Criteria:

* child 2 to 5 years old
* parent reports reason for referral is child behavior problems
* parent is a biological or adoptive parent, or legal guardian of child

Exclusion Criteria:

* parent is psychotic or actively abusing substances
* child is autistic or severely developmentally delayed
B: Inclusion Criteria:

* English speaking
* Live within 10 miles of UCLA
* 18 years of age or older
* Receive their prenatal and well-baby care from MediCal
* Live within 50 minutes of the three community intervention sites
* Reside within zip codes corresponding to the lowest performing schools in the broad Miami area
* Give birth to the target child at participating hospitals

Exclusion Criteria:

* Multiple birth greater than twins
* Existing Substance abuse
* Existing Mental Health issues
C: Inclusion Criteria:

-Parents, mothers as well as their partners, expecting their first child in the municipality of Aarhus are eligible for the study. This is because of the universal nature of the original program. Mothers are included if interested regardless of the fathers' decline. Biological fathers, registered partners, as well as non-registered partners are eligible.

Exclusion Criteria:

* Parents are excluded from the study if they are under the age of 18 years
* Not capable of managing own legal affairs
* Choose not to accept any routine pregnancy scans. These exclusion criteria are chosen to secure that study participants are legally responsible and that we are able to recruit them via the Department of Obstetrics and Gynaecology in connection with the nuchal translucency scan around week 12
* The father or partner is not included if the mother declines participation. The mother can choose to attend the Family Startup Program with a friend (i.e. a sister, friend or neighbor) but friends are not eligible for the study
* Finally, individuals are excluded if they are not able to understand the Danish oral presentation of the study information and hence cannot give informed consent
D: Inclusion Criteria:

Parent or primary caregiver of a child who fits the following criteria:

* Receives a positive result on behavioral screening

Exclusion Criteria:

Parent or primary caregiver of a child who fits the following criteria:

* Diagnosis of pervasive developmental disorder or global developmental delay

Answer: A
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Post-stroke Procedural Learning: From Neural Substrates to Therapeutic Modulation by Non-invasive Brain Stimulation
Brief Summary: Noninvasive brain stimulations (NIBS) will be used in chronic stroke patients to improve motor learning.

Functional magnetic resonance imaging will be used to evaluate the mechanisms underlying motor learning in healthy volunteers and in chronic stroke patients.


Options:
A: Inclusion Criteria:

* stroke with at least slight deficit

Exclusion Criteria:

* epilepsy
* contraindication to tDCS and/or to fMRI
* presence of metal in the head
* inability to understand / complete behavioral tasks
* chronic intake of alcohol or recreational drugs
* major health condition
* presence of pacemaker (for the fMRI part only)
* pregnancy
B: Inclusion Criteria:

1. Male or female aged 21-80 years;
2. First ever haemorrhagic or ischaemic hemiplegic stroke less than 1 month prior to study enrollment;
3. Upper extremity impairment of 0-45 out of a maximum score of 66 on the Fugl-Meyer assessment scale.
4. MMSE\>=24.
5. Be able to provide informed consent.

Exclusion Criteria:

pregnancy; cardiac pacemakers; orthodontics (braces); metal implant; history of epilepsy; sensorimotor disturbance due to other causes other than stroke; uncontrolled medical conditions including hypertension, diabetes mellitus and unstable angina; major depression and a history of psychotic disorders.
C: Inclusion Criteria:

* ischemic stroke causing arm weakness within 5-15 days
* no other neurological or psychiatric disease, who are able to perform study tasks

Exclusion Criteria:

* patients younger than 18 or older than 80 years
* patients with more than one disabling stroke
* Patients with bilateral motor impairment
* Patients with poor motivational capacity, history of severe alcohol or drug abuse
* Patients with severe language disturbances, particularly of receptive nature
* Patients with serious cognitive deficits (defined as equivalent to a MMS score of 23 or less)
* Patients with severe uncontrolled medical problems (e.g., seizures, progressive stroke syndromes, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer or renal disease, end-stage pulmonary or cardiovascular disease, or a deteriorated condition due to age or others),
* Patients with unstable thyroid disease
* Patients with increased intracranial pressure
* Patients with unstable cardiac arrhythmia
* Patients with contraindication to TMS or tDCS stimulation (pacemaker, an implanted medication pump, a metal plate in the skull, or metal objects inside the eye or skull, patients who had a craniotomy, skin lesions at the site of stimulation)
* Patients who are not available for follow-up at 3 and 12 months
* Pregnancy
* Patients with contraindication to MRI will not participate in MRI
D: Inclusion Criteria:

* first major unilateral hemispheric stroke,
* english speaking,
* adequate verbal communication,
* discharged home or residential care

Exclusion Criteria:

* serious comorbidities (eg. cancer, mobility limiting arthritis, leg amputation)

Answer: A