Please select the eligibility criteria that correspond to the clinical trial below.
Title: Cheese Consumption and Human Microvascular Function
Brief Summary: Increased dairy intake is associated with improved measures of blood vessel health. Dairy cheese, however, is often high in sodium. Dietary sodium can impair blood vessel function. The researchers examine if and how natural cheese may protect against impairments in blood vessel function caused by sodium. For this study, participants complete four 8-day controlled feeding periods in which they eat cheese (6 oz/day) or no cheese during a low-sodium or high-sodium base-diet. The participants complete baseline experiments while on their normal personal diet and then repeat experiments at the end of each controlled feeding period. In some of our experiments, the researchers use a technique called "microdialysis" (MD). With MD, the researchers perfuse some research drugs into the skin on the forearm through tiny tubing that mimics capillaries. These MD drugs mimic or block substances the body naturally makes to control the small blood vessels in the skin. The drugs remain in nickel-sized areas around the tubing and do not go into the rest of the body. The researchers also use a standard technique called "flow mediated dilation" (FMD) that uses blood pressure cuffs and ultrasound to look at the health of larger blood vessels in the body. FMD includes placing a small tablet of nitroglycerin under the tongue during part of the test.


Options:
A: Inclusion Criteria:

* Subjects aged 40 years and above

  * With systolic BP \<140 and diastolic \< 90 mmHg
  * Not receiving pharmacological antihypertensive medications

Exclusion Criteria:

* Subjects with following conditions would be excluded:

  * Diabetes mellitus (positive history of diabetes or fasting blood sugar ≥ 126 mg/dl)
  * Renal insufficiency (serum creatinine of 1.4 mg/dl or above)
  * Pregnant or lactating women
B: Children

Inclusion Criteria:

* All children in Grade 5 of primary schools (age about 11 years) are eligible for the study.

Exclusion Criteria:

* Children who do not have lunch or dinner at their own home will be excluded.

Adult family members:

Inclusion Criteria:

* For each participating child, we will recruit two adult family members. All adult family members who share the same meals with the child are eligible for the study.

Exclusion Criteria:

* If more than two adults in one family agree to take part in the study, we will select two of them (i.e. one male and one female) in the order of grandparents, parents, uncles and aunties.
C: Inclusion Criteria:

* Seated systolic pressure 120-140 mmHg
* Seated diastolic pressure 70-90 mmHg.
* Normoglycemic (HbA1C \<5.7%)

Exclusion Criteria:

* Taking pharmacotherapy that alters peripheral vascular control
* Pregnancy
* Breastfeeding
* Females taking contraceptives (pills, patches, shots, etc.) or hormone replacement therapy
* Taking illicit and/or recreational drugs
* Use of nicotine containing-products (e.g. smoking, chewing tobacco, etc.)
* Known allergy to latex or investigative substances
D: Inclusion Criteria:

* normal blood pressure
* men, Women, minorities
* ECG within normal limits
* screening blood panel within normal limits

Exclusion Criteria:

* high blood pressure (\>140/90 mmHg)
* history of cardiovascular disease
* history of cancer
* history of diabetes
* history of kidney disease
* obesity (BMI \> 30 kg/m2)
* smoking or tobacco use
* current pregnancy
* nursing mothers
* communication barriers

Answer: C