Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Trial of Accelerated Adjuvant Chemotherapy With Capecitabine in Early Breast Cancer (TACT2)
Brief Summary: RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Giving combination chemotherapy after surgery may kill any remaining tumor cells. It is not yet known which combination chemotherapy regimen is more effective in treating early stage breast cancer that has been removed by surgery.

PURPOSE: This randomized phase III trial is studying four different combination chemotherapy regimens to compare how well they work in treating patients with early stage breast cancer that has been removed by surgery.


Options:
A: Intervention Type: BIOLOGICAL; Name: trastuzumab; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: capecitabine; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: docetaxel; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: epirubicin hydrochloride; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: adjuvant therapy; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: neoadjuvant therapy; Assigned to Arm(s): N/A
B: Arm Label: resp: 4xTAC; Type: EXPERIMENTAL; Interventions: Drug: TAC | Arm Label: resp: 6xTAC; Type: EXPERIMENTAL; Interventions: Drug: TAC | Arm Label: nonResp: 4xTAC; Type: EXPERIMENTAL; Interventions: Drug: TAC | Arm Label: nonResp: 4xNX; Type: EXPERIMENTAL; Interventions: Drug: NX | Intervention Type: DRUG; Name: TAC; Assigned to Arm(s): nonResp: 4xTAC, resp: 4xTAC, resp: 6xTAC | Intervention Type: DRUG; Name: NX; Assigned to Arm(s): nonResp: 4xNX
C: Arm Label: Epi-CMF; Type: ACTIVE_COMPARATOR; Interventions: Drug: cyclophosphamide, Drug: epirubicin hydrochloride, Drug: fluorouracil, Drug: methotrexate, Procedure: adjuvant therapy | Arm Label: Accelerated Epi-CMF; Type: EXPERIMENTAL; Interventions: Biological: pegfilgrastim, Drug: cyclophosphamide, Drug: epirubicin hydrochloride, Drug: fluorouracil, Drug: methotrexate, Procedure: adjuvant therapy | Arm Label: Epi-Capecitabine; Type: EXPERIMENTAL; Interventions: Drug: capecitabine, Drug: epirubicin hydrochloride, Procedure: adjuvant therapy | Arm Label: Accelerated Epi-Capecitabine; Type: EXPERIMENTAL; Interventions: Biological: pegfilgrastim, Drug: capecitabine, Drug: epirubicin hydrochloride, Procedure: adjuvant therapy | Intervention Type: BIOLOGICAL; Name: pegfilgrastim; Assigned to Arm(s): Accelerated Epi-CMF, Accelerated Epi-Capecitabine | Intervention Type: DRUG; Name: capecitabine; Assigned to Arm(s): Accelerated Epi-Capecitabine, Epi-Capecitabine | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): Accelerated Epi-CMF, Epi-CMF | Intervention Type: DRUG; Name: epirubicin hydrochloride; Assigned to Arm(s): Accelerated Epi-CMF, Accelerated Epi-Capecitabine, Epi-CMF, Epi-Capecitabine | Intervention Type: DRUG; Name: fluorouracil; Assigned to Arm(s): Accelerated Epi-CMF, Epi-CMF | Intervention Type: DRUG; Name: methotrexate; Assigned to Arm(s): Accelerated Epi-CMF, Epi-CMF | Intervention Type: PROCEDURE; Name: adjuvant therapy; Assigned to Arm(s): Accelerated Epi-CMF, Accelerated Epi-Capecitabine, Epi-CMF, Epi-Capecitabine
D: Arm Label: Arm A: EC-T; Type: ACTIVE_COMPARATOR; Interventions: Drug: Docetaxel, Drug: Epirubicin, Drug: Cyclophosphamide | Arm Label: Arm B: ET-X; Type: EXPERIMENTAL; Interventions: Drug: Docetaxel, Drug: Capecitabine, Drug: Epirubicin | Intervention Type: DRUG; Name: Docetaxel; Assigned to Arm(s): Arm A: EC-T, Arm B: ET-X | Intervention Type: DRUG; Name: Capecitabine; Assigned to Arm(s): Arm B: ET-X | Intervention Type: DRUG; Name: Epirubicin; Assigned to Arm(s): Arm A: EC-T, Arm B: ET-X | Intervention Type: DRUG; Name: Cyclophosphamide; Assigned to Arm(s): Arm A: EC-T

Answer: C