Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Therapeutic Hypothermia After Cardiac Arrest in Non Shockable Rhythm at Rescue Arrival: The HYPERION Study
Brief Summary: Cardiac arrest is at present a major cause of mortality as well as a cause of disability for the surviving victims.In Europe, every year counts as 300,000 cardiac arrests responsible for 250,000 deaths. Thus, less than 20 % of patients discharged home with impaired quality of life associated with symptoms of tiredness, stress, anxiety. The prognosis is related to the initial cardiac rhythm present during the initiation of resuscitation. Recent progress in the improvement of mortality and neurological outcome has been achieved over the last decade thanks to the systematic implementation of a period of targeted temperature control between 32 and 34 ° C in patients who benefited from the realization of at least one electrical external shock.

There are theoretical and clinical arguments to think that achieving the same way a period of targeted temperature control between 32 and 34 ° C in patients treated for cardiac arrest with a non- shockable rhythm on arrival can also benefit from this procedure. However other arguments are against this hypothesis including an increase in the risk of infection , worsening of the patient's hemodynamic status with no benefit to him. To answer this question, we conduce a randomized multicenter study testing the potential improvement of neurological outcome through this procedure targeted temperature control between 32.5 and 33.5 ° C in these patients.


Options:
A: Arm Label: Targeted controlled temperature between 32.5 and 33.5°C; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Targeted controlled temperature between 32.5 and 33.5°C, Procedure: Targeted controlled temperature between 36.5 and 37.5°C | Arm Label: Targeted controlled temperature between 36.5 and 37.5°C; Type: PLACEBO_COMPARATOR; Interventions: Procedure: Targeted controlled temperature between 36.5 and 37.5°C | Intervention Type: PROCEDURE; Name: Targeted controlled temperature between 32.5 and 33.5°C; Assigned to Arm(s): Targeted controlled temperature between 32.5 and 33.5°C | Intervention Type: PROCEDURE; Name: Targeted controlled temperature between 36.5 and 37.5°C; Assigned to Arm(s): Targeted controlled temperature between 32.5 and 33.5°C, Targeted controlled temperature between 36.5 and 37.5°C
B: Arm Label: Moderate hypothermia; Type: OTHER; Interventions: Other: Therapeutic Hypothermia | Arm Label: Mild Hypothermia; Type: ACTIVE_COMPARATOR; Interventions: Other: Therapeutic Hypothermia | Intervention Type: OTHER; Name: Therapeutic Hypothermia; Assigned to Arm(s): Mild Hypothermia, Moderate hypothermia
C: Arm Label: 24 hours hypothermia; Type: ACTIVE_COMPARATOR; Interventions: Other: Therapeutic hypothermia | Arm Label: 48 hours hypothermoa; Type: EXPERIMENTAL; Interventions: Other: Therapeutic hypothermia | Intervention Type: OTHER; Name: Therapeutic hypothermia; Assigned to Arm(s): 24 hours hypothermia, 48 hours hypothermoa
D: Arm Label: Normothermia; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Standard care with early treatment of fever | Arm Label: Hypothermia; Type: EXPERIMENTAL; Interventions: Procedure: Targeted temperature management to 33°C | Intervention Type: PROCEDURE; Name: Targeted temperature management to 33°C; Assigned to Arm(s): Hypothermia | Intervention Type: PROCEDURE; Name: Standard care with early treatment of fever; Assigned to Arm(s): Normothermia

Answer: A