Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Single-Blind, Dose-Rising, Placebo-Controlled, Crossover Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Tolerability of Exenatide in Adolescent Subjects With Type 2 Diabetes Mellitus
Brief Summary: This study will be the first evaluation of exenatide in adolescent subjects with type 2 diabetes mellitus and is designed to evaluate the blood levels of the drug (pharmacokinetics), the drug's biochemical and physiological effects (pharmacodynamics), and tolerability of exenatide in these subjects.


Options:
A: Arm Label: Lira 0.6 + Met; Type: EXPERIMENTAL; Interventions: Drug: liraglutide, Drug: metformin, Drug: placebo | Arm Label: Lira 1.2 + Met; Type: EXPERIMENTAL; Interventions: Drug: metformin, Drug: placebo, Drug: liraglutide | Arm Label: Lira 1.8 + Met; Type: EXPERIMENTAL; Interventions: Drug: metformin, Drug: placebo, Drug: liraglutide | Arm Label: Met Mono; Type: ACTIVE_COMPARATOR; Interventions: Drug: metformin, Drug: placebo | Arm Label: Met + Glim; Type: ACTIVE_COMPARATOR; Interventions: Drug: metformin, Drug: glimepiride, Drug: placebo | Intervention Type: DRUG; Name: liraglutide; Assigned to Arm(s): Lira 0.6 + Met | Intervention Type: DRUG; Name: metformin; Assigned to Arm(s): Lira 0.6 + Met, Lira 1.2 + Met, Lira 1.8 + Met, Met + Glim, Met Mono | Intervention Type: DRUG; Name: glimepiride; Assigned to Arm(s): Met + Glim | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Lira 0.6 + Met, Lira 1.2 + Met, Lira 1.8 + Met, Met Mono | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Met + Glim, Met Mono | Intervention Type: DRUG; Name: liraglutide; Assigned to Arm(s): Lira 1.2 + Met | Intervention Type: DRUG; Name: liraglutide; Assigned to Arm(s): Lira 1.8 + Met
B: Arm Label: Lira placebo/Lira 2.4 mg/Lira 3.0 mg; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo | Arm Label: Lira 1.2 mg/Lira 3.0 mg; Type: EXPERIMENTAL; Interventions: Drug: liraglutide | Arm Label: Lira 1.8 mg/Lira 3.0 mg; Type: EXPERIMENTAL; Interventions: Drug: liraglutide | Arm Label: Lira 2.4 mg/Lira 3.0 mg; Type: EXPERIMENTAL; Interventions: Drug: liraglutide | Arm Label: Liraglutide 3.0 mg; Type: EXPERIMENTAL; Interventions: Drug: liraglutide, Drug: placebo | Arm Label: Orlistat; Type: ACTIVE_COMPARATOR; Interventions: Drug: orlistat | Intervention Type: DRUG; Name: liraglutide; Assigned to Arm(s): Lira 1.2 mg/Lira 3.0 mg, Lira 1.8 mg/Lira 3.0 mg, Lira 2.4 mg/Lira 3.0 mg, Liraglutide 3.0 mg | Intervention Type: DRUG; Name: orlistat; Assigned to Arm(s): Orlistat | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Lira placebo/Lira 2.4 mg/Lira 3.0 mg, Liraglutide 3.0 mg
C: Arm Label: Lira 1.2 mg -> Lira 1.2 mg -> Lira 1.2 mg; Type: EXPERIMENTAL; Interventions: Drug: liraglutide, Drug: metformin | Arm Label: Lira 1.8 mg -> Lira 1.8 mg -> Lira 1.8 mg; Type: EXPERIMENTAL; Interventions: Drug: metformin, Drug: liraglutide | Arm Label: Sita -> Sita; Type: ACTIVE_COMPARATOR; Interventions: Drug: sitagliptin, Drug: metformin | Arm Label: Sita -> Sita -> Lira 1.2 mg; Type: EXPERIMENTAL; Interventions: Drug: liraglutide, Drug: sitagliptin, Drug: metformin | Arm Label: Sita -> Sita -> Lira 1.8 mg; Type: EXPERIMENTAL; Interventions: Drug: sitagliptin, Drug: metformin, Drug: liraglutide | Intervention Type: DRUG; Name: liraglutide; Assigned to Arm(s): Lira 1.2 mg -> Lira 1.2 mg -> Lira 1.2 mg, Sita -> Sita -> Lira 1.2 mg | Intervention Type: DRUG; Name: sitagliptin; Assigned to Arm(s): Sita -> Sita, Sita -> Sita -> Lira 1.2 mg, Sita -> Sita -> Lira 1.8 mg | Intervention Type: DRUG; Name: metformin; Assigned to Arm(s): Lira 1.2 mg -> Lira 1.2 mg -> Lira 1.2 mg, Lira 1.8 mg -> Lira 1.8 mg -> Lira 1.8 mg, Sita -> Sita, Sita -> Sita -> Lira 1.2 mg, Sita -> Sita -> Lira 1.8 mg | Intervention Type: DRUG; Name: liraglutide; Assigned to Arm(s): Lira 1.8 mg -> Lira 1.8 mg -> Lira 1.8 mg, Sita -> Sita -> Lira 1.8 mg
D: Arm Label: Sequence 1; Type: EXPERIMENTAL; Interventions: Drug: Exenatide - Exenatide - Placebo | Arm Label: Sequence 2; Type: EXPERIMENTAL; Interventions: Drug: Exenatide - Placebo - Exenatide | Arm Label: Sequence 3; Type: EXPERIMENTAL; Interventions: Drug: Placebo - Exenatide - Exenatide | Intervention Type: DRUG; Name: Exenatide - Exenatide - Placebo; Assigned to Arm(s): Sequence 1 | Intervention Type: DRUG; Name: Exenatide - Placebo - Exenatide; Assigned to Arm(s): Sequence 2 | Intervention Type: DRUG; Name: Placebo - Exenatide - Exenatide; Assigned to Arm(s): Sequence 3

Answer: D