Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: The Efficacy of Neuromuscular Electrical Stimulation for Improving Quadriceps Activation in Women With Medial Tibiofemoral Osteoarthritis
Brief Summary: Patients with knee osteoarthritis (OA) often have decreased thigh muscle strength. This muscle weakness is thought to originate from centers in the brain and spinal cord that restrict recruitment of fibers responsible for muscle contraction. An inability to fully contract muscles surrounding the knee joint impairs patients' abilities to perform activities of daily living (i.e. walking, climbing stairs) and may even contribute to further joint degeneration.

Establishing therapies aimed at increasing muscle strength, restoring normal function, and possibly slowing the processes involved in the development of knee OA is essential in order to enhance the quality of life in the adult population plagued with this degenerative joint condition.

Electrical muscle stimulation applied to the thigh is a promising therapy that has been shown to successfully restore muscle strength, however how long the treatment lasts and its influence on functional outcomes remains unknown. In order for electrical muscle stimulation to be of value it must result in sustained improvements in muscle strength and functional outcomes. Therefore, the purpose of the proposed investigation is to determine if electrical muscle stimulation can restore thigh muscle strength and improve functional outcomes in patients with knee osteoarthritis.


Options:
A: Arm Label: NMES group; Type: EXPERIMENTAL; Interventions: Other: Neuromuscular electrical stimulation, Other: Endurance training, Other: Quadriceps strength training | Arm Label: Control group; Type: SHAM_COMPARATOR; Interventions: Other: Endurance training, Other: Quadriceps strength training | Intervention Type: OTHER; Name: Neuromuscular electrical stimulation; Assigned to Arm(s): NMES group | Intervention Type: OTHER; Name: Endurance training; Assigned to Arm(s): Control group, NMES group | Intervention Type: OTHER; Name: Quadriceps strength training; Assigned to Arm(s): Control group, NMES group
B: Arm Label: Functional electrical stimulation; Type: EXPERIMENTAL; Interventions: Procedure: Functional electrical stimulation | Arm Label: Medium-frequency alternating current; Type: EXPERIMENTAL; Interventions: Procedure: Medium-frequency alternating current | Arm Label: Burst-modulated alternating current; Type: EXPERIMENTAL; Interventions: Procedure: Burst-modulated alternating current | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Procedure: Placebo | Intervention Type: PROCEDURE; Name: Medium-frequency alternating current; Assigned to Arm(s): Medium-frequency alternating current | Intervention Type: PROCEDURE; Name: Burst-modulated alternating current; Assigned to Arm(s): Burst-modulated alternating current | Intervention Type: PROCEDURE; Name: Placebo; Assigned to Arm(s): Placebo | Intervention Type: PROCEDURE; Name: Functional electrical stimulation; Assigned to Arm(s): Functional electrical stimulation
C: Arm Label: No Treatment; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Electrical Stimulation; Type: EXPERIMENTAL; Interventions: Device: Electrical Stimulation | Intervention Type: DEVICE; Name: Electrical Stimulation; Assigned to Arm(s): Electrical Stimulation
D: Arm Label: NMES; Type: EXPERIMENTAL; Interventions: Device: Neuromuscular Electrostimulation (NMES) CareStim Muscle Stimulation Device (Care Rehab; McLean, VA) | Arm Label: Sham; Type: SHAM_COMPARATOR; Interventions: Device: Sham | Intervention Type: DEVICE; Name: Neuromuscular Electrostimulation (NMES) CareStim Muscle Stimulation Device (Care Rehab; McLean, VA); Assigned to Arm(s): NMES | Intervention Type: DEVICE; Name: Sham; Assigned to Arm(s): Sham

Answer: C