Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Blinded, Multicenter Study to Evaluate the Efficacy and Safety of Varisolve Polidocanol Endovenous Microfoam (PEM) 0.5% and 1% Compared to Vehicle for the Treatment on Saphenofemoral Junction (SFJ) Incompetence "VANISH-2"
Brief Summary: Varicose veins are enlarged, noticeably bulging veins, which commonly occur in the legs and may cause discomfort. In this study, patients with varicose veins in the legs will be participating. The purpose of this research study is to evaluate the safety and effectiveness of three different concentrations of an investigational drug, Polidocanol Endovenous Microfoam (PEM) compared to vehicle (inactive solution) in treating the symptoms and appearance of varicose veins.


Options:
A: Arm Label: polidocanol injectable foam, 0.125%; Type: EXPERIMENTAL; Interventions: Drug: polidocanol injectable foam, 0.125% | Arm Label: polidocanol injectable foam, 0.5%; Type: EXPERIMENTAL; Interventions: Drug: polidocanol injectable foam, 0.5% | Arm Label: polidocanol injectable foam, 1.0%; Type: EXPERIMENTAL; Interventions: Drug: polidocanol injectable foam, 1.0% | Arm Label: Vehicle; Type: PLACEBO_COMPARATOR; Interventions: Drug: Vehicle | Intervention Type: DRUG; Name: polidocanol injectable foam, 0.125%; Assigned to Arm(s): polidocanol injectable foam, 0.125% | Intervention Type: DRUG; Name: polidocanol injectable foam, 0.5%; Assigned to Arm(s): polidocanol injectable foam, 0.5% | Intervention Type: DRUG; Name: polidocanol injectable foam, 1.0%; Assigned to Arm(s): polidocanol injectable foam, 1.0% | Intervention Type: DRUG; Name: Vehicle; Assigned to Arm(s): Vehicle
B: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Procedure: crossectomy and short stripping | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Procedure: ultrasound guided sclerotherapy with foam | Arm Label: 3; Type: ACTIVE_COMPARATOR; Interventions: Procedure: endovenous laser therapy | Intervention Type: PROCEDURE; Name: crossectomy and short stripping; Assigned to Arm(s): 1 | Intervention Type: PROCEDURE; Name: ultrasound guided sclerotherapy with foam; Assigned to Arm(s): 2 | Intervention Type: PROCEDURE; Name: endovenous laser therapy; Assigned to Arm(s): 3
C: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Drug: Varisolve (Polidocanol Endovenous Microfoam) | Arm Label: 2; Type: PLACEBO_COMPARATOR; Interventions: Drug: Agitated Saline | Intervention Type: DRUG; Name: Varisolve (Polidocanol Endovenous Microfoam); Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Agitated Saline; Assigned to Arm(s): 2
D: Arm Label: EndoVenous Laser Ablation; Type: ACTIVE_COMPARATOR; Interventions: Device: EVLA, Drug: Lidocaine with 1:200,000 epinephrine solution, Drug: Sodium Bicarbonate | Arm Label: MechanoChemical Ablation (ClariVein®); Type: ACTIVE_COMPARATOR; Interventions: Device: ClariVein®, Drug: Lidocaine with 1:200,000 epinephrine solution, Drug: Sodium Tetradecyl Sulphate | Intervention Type: DEVICE; Name: EVLA; Assigned to Arm(s): EndoVenous Laser Ablation | Intervention Type: DEVICE; Name: ClariVein®; Assigned to Arm(s): MechanoChemical Ablation (ClariVein®) | Intervention Type: DRUG; Name: Lidocaine with 1:200,000 epinephrine solution; Assigned to Arm(s): EndoVenous Laser Ablation, MechanoChemical Ablation (ClariVein®) | Intervention Type: DRUG; Name: Lidocaine with 1:200,000 epinephrine solution; Assigned to Arm(s): EndoVenous Laser Ablation | Intervention Type: DRUG; Name: Sodium Bicarbonate; Assigned to Arm(s): EndoVenous Laser Ablation | Intervention Type: DRUG; Name: Sodium Tetradecyl Sulphate; Assigned to Arm(s): MechanoChemical Ablation (ClariVein®)

Answer: A