Please select the eligibility criteria that correspond to the clinical trial below.
Title: Comparative Electrocardiographic Effects of Intravenous Ondansetron and Granisetron in Patients Undergoing Surgery for Carcinoma Breast: A Prospective Single Blind Randomised Trial
Brief Summary: Postoperative nausea and vomiting \[PONV\] are common and distressing symptoms after surgery performed under general anaesthesia. 5HT3 antagonists are routinely used for prevention as well as treatment of PONV. After IRB approval we compared the effects of ondansetron and granisetron on the various intervals on ECG in 70 patients undergoing elective surgery for carcinoma breast after written informed consent. The demographic data was collected. The administration of the anaesthetic was left to the discretion of the operating room staff specialist. In the Postoperative Recovery Room patients were randomised to receive 8 mgs of ondansetron or 1 mg of granisetron intravenously. Serial ECGs were recorded at 0 mins (before injection of study drug), 2 mins, 5 mins, 15mins, 1 hour and 2 hours. Pulse rate, Non-invasive blood pressure and SpO2 were also recorded. T


Options:
A: Inclusion Criteria:

* All patients undergoing breast surgery for carcinoma breast.
* Patients between ages 18 to 60 years.
* ASA I \\ II \\ III
* Patients weight between 40 and 70 kilograms.

Exclusion Criteria:

* Patient refusing consent
* Prophylactic anti emetic drug administration during intraoperative period
* Known case of prolonged QTc interval
* Known case decompensated cardiomyopathy
* Known case of cardiac arrhythmia or bundle branch block
* Case of congestive heart failure with left ventricular ejection fraction \<40%
* Abnormal serum level of potassium, calcium, magnesium
B: Inclusion Criteria:

* Patient undergoing laparoscopic gynecologic surgery.
* Patient who takes fentanyl based IV PCA
* ASA class I-II

Exclusion Criteria:

* allergy to aprepitant
* take another antiemetics before surgery
* decreased liver function
* psychological disease
* who cannot speak Korean
* take medicines that interacts with emend who do not agree to the study
C: Inclusion Criteria:

* patients ≥ 18 \< 75 years
* ASA physical status I-II
* planned duration of anesthesia ≥ 60 minutes
* Apfel score ≥ 2-3
* elective (laparoscopic) surgery (abdominal, gynecological)
* women: with a highly effective contraception, defined as methods with a pearl index \< 1 (i.e. hormonal contraceptives, IUD)

Exclusion Criteria:

* history of hypersensitivity to any used drugs or additive components used for preparation and stabilization of the named drugs in this trial
* history or reasonable suspicion of malignant hyperthermia and/or degenerative neuromuscular disease, in the subject observed or blood relatives
* history of liver function disorders, leucocytosis and unclear fever after usage of halogenated anesthetics.
* any indisposition that may be aggravated by the use of the drugs investigated:
* liver and/or kidney function disorders
* severe acute or chronic infectious disease (i.e. viral, bacterial, fungal)
* elevated intracranial pressure
* history of gastrointestinal ulcer(s) or inflammatory bowel disease
* severe metabolic disorders
* hematoporphyria
* glaucoma
* hearing disorders
* any disease including air-filled closed cavities, such as pneumothorax, ileus
* pregnancy and lactation period
* subjects under the age of 18 years
* ambulatory surgery
* any disease that is associated with the requirement of a high oxygen yield and/or
* risk of high oxygen consumption:
* severe lung and/or airway disease
* coronary heart disease and/or seriously impaired cardiac function
* severe psychiatric disorder
D: Inclusion Criteria:

* patients undergoing thyroid surgery

Exclusion Criteria:

* ASA physical class III or IV
* age \> 75 years
* pregnancy

Answer: A