Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Double-Blinded, Placebo Controlled Study to Evaluate the Tolerability and Safety of Rituximab When Given in Combination With Methotrexate and Etanercept (Enbrel) or Methotrexate and Adalimumab (Humira) in Subjects With Active Rheumatoid Arthritis
Brief Summary: The primary objective of this study was to evaluate the tolerability and safety of rituximab in combination with methotrexate (MTX) and etanercept or adalimumab in participants with active rheumatoid arthritis (RA). The secondary objective was to explore the efficacy of rituximab in combination with MTX and etanercept or adalimumab in participants with active RA.


Options:
A: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab, Drug: corticosteroids | Arm Label: 3; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab, Drug: corticosteroids | Arm Label: 4; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab | Arm Label: 5; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab, Drug: corticosteroids | Arm Label: 6; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab, Drug: corticosteroids | Arm Label: 7; Type: PLACEBO_COMPARATOR; Interventions: Drug: methotrexate, Drug: placebo | Arm Label: 8; Type: PLACEBO_COMPARATOR; Interventions: Drug: methotrexate, Drug: corticosteroids, Drug: placebo | Arm Label: 9; Type: PLACEBO_COMPARATOR; Interventions: Drug: methotrexate, Drug: corticosteroids, Drug: placebo | Intervention Type: DRUG; Name: methotrexate; Assigned to Arm(s): 1, 2, 3, 4, 5, 6, 7, 8, 9 | Intervention Type: DRUG; Name: rituximab; Assigned to Arm(s): 1, 2, 3, 4, 5, 6 | Intervention Type: DRUG; Name: corticosteroids; Assigned to Arm(s): 2, 3, 5, 6, 8, 9 | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): 7, 8, 9
B: Arm Label: Rituximab 1000 mg (Stage I patients); Type: EXPERIMENTAL; Interventions: Drug: Rituximab, Drug: Anti-inflammatory drugs | Arm Label: Rituximab 500 mg (Stage II patients); Type: EXPERIMENTAL; Interventions: Drug: Rituximab, Drug: Anti-inflammatory drugs | Intervention Type: DRUG; Name: Rituximab; Assigned to Arm(s): Rituximab 1000 mg (Stage I patients), Rituximab 500 mg (Stage II patients) | Intervention Type: DRUG; Name: Anti-inflammatory drugs; Assigned to Arm(s): Rituximab 1000 mg (Stage I patients), Rituximab 500 mg (Stage II patients)
C: Arm Label: Placebo Plus Methotrexate; Type: PLACEBO_COMPARATOR; Interventions: Drug: Methotrexate, Other: Placebo | Arm Label: Rituximab plus Methotrexate; Type: EXPERIMENTAL; Interventions: Drug: MabThera/Rituxan, Drug: Methotrexate | Intervention Type: DRUG; Name: MabThera/Rituxan; Assigned to Arm(s): Rituximab plus Methotrexate | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): Placebo Plus Methotrexate, Rituximab plus Methotrexate | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo Plus Methotrexate
D: Arm Label: Double-blind/Open Label Rituximab; Type: EXPERIMENTAL; Interventions: Biological: IDEC-C2B8 (rituximab), Drug: Methotrexate, Drug: Etanercept, Drug: Adalimumab, Drug: Methylprednisolone, Dietary Supplement: Folate | Arm Label: Double-blind Placebo/Open Label Rituximab; Type: OTHER; Interventions: Drug: Placebo, Drug: Methotrexate, Drug: Etanercept, Drug: Adalimumab, Drug: Methylprednisolone, Dietary Supplement: Folate | Intervention Type: BIOLOGICAL; Name: IDEC-C2B8 (rituximab); Assigned to Arm(s): Double-blind/Open Label Rituximab | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Double-blind Placebo/Open Label Rituximab | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): Double-blind Placebo/Open Label Rituximab, Double-blind/Open Label Rituximab | Intervention Type: DRUG; Name: Etanercept; Assigned to Arm(s): Double-blind Placebo/Open Label Rituximab, Double-blind/Open Label Rituximab | Intervention Type: DRUG; Name: Adalimumab; Assigned to Arm(s): Double-blind Placebo/Open Label Rituximab, Double-blind/Open Label Rituximab | Intervention Type: DRUG; Name: Methylprednisolone; Assigned to Arm(s): Double-blind Placebo/Open Label Rituximab, Double-blind/Open Label Rituximab | Intervention Type: DIETARY_SUPPLEMENT; Name: Folate; Assigned to Arm(s): Double-blind Placebo/Open Label Rituximab, Double-blind/Open Label Rituximab

Answer: D