Please select the eligibility criteria that correspond to the clinical trial below.
Title: Early Detection and Intervention for the Prevention of Psychosis Project
Brief Summary: EDIPP is a multisite trial of early identification and intervention to prevent the onset of psychosis in adolescents and young adults, carried out at six sites across the United States. The hypothesis is that very early identification and intervention will be effective in delaying or preventing onset of psychosis and improving social and occupational functioning.


Options:
A: Inclusion Criteria:

* age 21 or older
* serious mental illness defined by an axis I diagnosis of major depression, bipolar disorder, schizoaffective disorder, or schizophrenia
* persistent impairment in multiple areas of functioning (e.g., work, school, self-care)
* body mass index (BMI) greater than 25
* able and willing to provide informed consent
* on stable pharmacological treatment (same psychiatric medications over prior 2 months)

Exclusion Criteria:

* residing in nursing home or other institution
* diagnosis of dementia or significant cognitive impairment (MMSE\<24)
* unable to walk one city block
* pregnant or planning to become pregnant within the next 18 months
* unable to speak English
* terminal illness with life expectancy\<1 year
* current diagnosis of an active substance dependence disorder
B: Inclusion Criteria:

1. General criteria

   * Age between 17 and 36 years
   * male or female, in- or outpatients
   * written informed consent, for patients below 18 years also signed by their parents
2. Special criteria (presented within the last three months prior to the study)

   1. Self-experienced neuropsychological deficits (basic symptoms)

      * Thought interferences
      * Compulsory like perseverance of thoughts
      * Thought pressure
      * Thought blockages
      * Disturbances of receptive language, either heard or read
      * Decreased ability to discriminate between ideas and perception, fantasy and true memories
      * Unstable ideas of reference (subject-centrism)
      * Derealisation
      * Visual perceptual disturbances (blurred vision, transitory blindness, partial seeing, hypersensitivity of light, etc..)
      * Acoustic perceptual disturbances (hypersensitivity to sounds or noise (hypersensitivity to sounds or noise, acoasms, etc.) AND/OR
   2. Reduction in the Global Assessment of Functioning Score (DSM IV) of at least 30 points (within the past year) and at least one of the following risk factors:

      * First-degree relative with a lifetime-diagnosis of schizophrenia or
      * a schizophrenia spectrum disorder
      * Pre-or perinatal complications

Exclusion Criteria:

* Attenuated or transient positive symptomes
* Present or past diagnosis of a schizophrenic, schizophreniform, schizoaffective, delusional or bipolar according to DSM IV
* Present or past diagnosis a brief psychotic disorder according to DSM IV with a duration of more than one week or within the last 4 weeks regardless of its duration
* Diagnosis of delirium, dementia, amnestic or other cognitive disorder, mental retardation psychiatric disorder due to a somatic factor or related to the consumption of psychotropic substances according DSM IV
* Alcohol- or drug abuse within the last three months prior to inclusion according to DSM IV
* Deases of the central nervous system (inflammatory, traumatic, epilepsy etc.)
C: Inclusion Criteria:

* Age between 12 years, 0 months and 35 years, 11 months
* Speaks and writes English
* Availability of at least one family member for treatment
* Meets criteria for one of three prodromal syndromes as assessed by the

Structured Interview for Prodromal Syndromes:

1. attenuated positive symptoms that are sub-psychotic in duration and intensity and have begun or worsened in the past year;
2. brief intermittent psychosis, defined as or syndromal psychotic symptoms that are have been present intermittently with onset in the previous 3 months; or
3. genetic risk and deterioration, defined as a diagnosis of schizotypal personality disorder or having a first degree relative with a psychotic disorder, plus having experienced a substantial decline (30% or greater) in Global Assessment of Functioning scores in the last year.

Exclusion Criteria:

* Diagnosis of schizophrenia or schizoaffective disorder
* Pervasive developmental disorders
* Current substance or alcohol dependence
* Neurological disorders
D: Inclusion Criteria:

* Subjects in the age range of 12-25 and living in the experimental catchment area may be enrolled in the EDIPP study based on meeting at least one of the inclusion requirements AND none of the exclusion criteria;
* Screening process indicates symptoms equivalent to a minimum rating of '1' on at least one positive symptom of psychosis;
* Screening process indicates a likely family history of first degree relative with psychotic illness plus a deterioration in functioning equivalent to a 30% drop in functioning score over the past year; OR
* Screening process indicates a likely history of schizotypal personality disorder plus a deterioration in functioning equivalent to a 30% drop in functioning over the past year.

Exclusion Criteria:

* Outside the age range of 12 to 25 years;
* History of intelligence quotient (IQ) below 70 (based on school records, not tested at PIER);
* More than one month duration of psychosis (guided by the criteria of at least one 6 on the Positive Symptom sub-scale of the Scale of Positive Symptoms (SOPS);
* History of previous psychotic episode, whether or not treatment was received;
* Taken antipsychotic medication for more than 30 days at a therapeutic dose for psychotic symptoms;
* Either the young person being screened for the study or both parents do not speak proficient English;
* Female is pregnant at baseline (inquired on the screening interview); AND
* Subject is a prisoner.

Answer: D