Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Immunogenicity of the Human Rotavirus Vaccine (Rotarix™) at Varying Schedules, Doses, and Ages in Rural Ghana
Brief Summary: The purpose of this study is to determine whether giving the Human Rotavirus Vaccine on alternate dosing schedules will enhance the immune response to the vaccine in a low-resource, high-burden country in Africa. Alternate dosing schedules studied include giving the 2-dose vaccine schedule at a slightly older age and giving an additional dose of the vaccine.


Options:
A: Arm Label: Low dose RSV F Vaccine with Dose 1 of Aluminum Adjuvant; Type: EXPERIMENTAL; Interventions: Biological: Low dose RSV F Antigen, Biological: Dose 1 of Aluminum Adjuvant, Biological: Placebo | Arm Label: Low dose RSV F Vaccine with Dose 2 of Aluminum Adjuvant; Type: EXPERIMENTAL; Interventions: Biological: Low dose RSV F Antigen, Biological: Dose 2 of Aluminum Adjuvant | Arm Label: Low dose RSV F Vaccine with Dose 3 of Aluminum Adjuvant; Type: EXPERIMENTAL; Interventions: Biological: Low dose RSV F Antigen, Biological: Dose 3 of Aluminum Adjuvant | Arm Label: Low dose RSV F Vaccine with Dose 4 of Aluminum Adjuvant; Type: EXPERIMENTAL; Interventions: Biological: Low dose RSV F Antigen, Biological: Dose 4 of Aluminum Adjuvant | Arm Label: High dose RSV F Vaccine with Dose 2 of Aluminum Adjuvant; Type: EXPERIMENTAL; Interventions: Biological: High dose RSV F Antigen, Biological: Dose 2 of Aluminum Adjuvant, Biological: Placebo | Arm Label: High dose RSV F Vaccine with Dose 3 of Aluminum Adjuvant; Type: EXPERIMENTAL; Interventions: Biological: High dose RSV F Antigen, Biological: Dose 3 of Aluminum Adjuvant, Biological: Placebo | Arm Label: High dose RSV F Vaccine with Dose 4 of Aluminum Adjuvant; Type: EXPERIMENTAL; Interventions: Biological: High dose RSV F Antigen, Biological: Dose 4 of Aluminum Adjuvant, Biological: Placebo | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Intervention Type: BIOLOGICAL; Name: Low dose RSV F Antigen; Assigned to Arm(s): Low dose RSV F Vaccine with Dose 1 of Aluminum Adjuvant, Low dose RSV F Vaccine with Dose 2 of Aluminum Adjuvant, Low dose RSV F Vaccine with Dose 3 of Aluminum Adjuvant, Low dose RSV F Vaccine with Dose 4 of Aluminum Adjuvant | Intervention Type: BIOLOGICAL; Name: High dose RSV F Antigen; Assigned to Arm(s): High dose RSV F Vaccine with Dose 2 of Aluminum Adjuvant, High dose RSV F Vaccine with Dose 3 of Aluminum Adjuvant, High dose RSV F Vaccine with Dose 4 of Aluminum Adjuvant | Intervention Type: BIOLOGICAL; Name: Dose 1 of Aluminum Adjuvant; Assigned to Arm(s): Low dose RSV F Vaccine with Dose 1 of Aluminum Adjuvant | Intervention Type: BIOLOGICAL; Name: Dose 2 of Aluminum Adjuvant; Assigned to Arm(s): High dose RSV F Vaccine with Dose 2 of Aluminum Adjuvant, Low dose RSV F Vaccine with Dose 2 of Aluminum Adjuvant | Intervention Type: BIOLOGICAL; Name: Dose 3 of Aluminum Adjuvant; Assigned to Arm(s): High dose RSV F Vaccine with Dose 3 of Aluminum Adjuvant, Low dose RSV F Vaccine with Dose 3 of Aluminum Adjuvant | Intervention Type: BIOLOGICAL; Name: Dose 4 of Aluminum Adjuvant; Assigned to Arm(s): High dose RSV F Vaccine with Dose 4 of Aluminum Adjuvant, Low dose RSV F Vaccine with Dose 4 of Aluminum Adjuvant | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): High dose RSV F Vaccine with Dose 2 of Aluminum Adjuvant, High dose RSV F Vaccine with Dose 3 of Aluminum Adjuvant, High dose RSV F Vaccine with Dose 4 of Aluminum Adjuvant, Low dose RSV F Vaccine with Dose 1 of Aluminum Adjuvant, Placebo
B: Arm Label: EDP-938 Arm A; Type: EXPERIMENTAL; Interventions: Drug: EDP-938 Dose 1 | Arm Label: EDP-938 Arm B; Type: EXPERIMENTAL; Interventions: Drug: EDP-938 Dose 2 | Arm Label: Placebo Arm C; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: EDP-938 Arm D; Type: EXPERIMENTAL; Interventions: Drug: EDP-938 Dose 3 | Arm Label: EDP-938 Arm E; Type: EXPERIMENTAL; Interventions: Drug: EDP-938 Dose 4 | Arm Label: Placebo Arm F; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: EDP-938 Dose 1; Assigned to Arm(s): EDP-938 Arm A | Intervention Type: DRUG; Name: EDP-938 Dose 2; Assigned to Arm(s): EDP-938 Arm B | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo Arm C | Intervention Type: DRUG; Name: EDP-938 Dose 3; Assigned to Arm(s): EDP-938 Arm D | Intervention Type: DRUG; Name: EDP-938 Dose 4; Assigned to Arm(s): EDP-938 Arm E | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo Arm F
C: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Biological: MEDI-534 | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Biological: MEDI-534 | Arm Label: 3; Type: EXPERIMENTAL; Interventions: Biological: MEDI-534 | Intervention Type: BIOLOGICAL; Name: MEDI-534; Assigned to Arm(s): 1 | Intervention Type: BIOLOGICAL; Name: MEDI-534; Assigned to Arm(s): 2 | Intervention Type: BIOLOGICAL; Name: MEDI-534; Assigned to Arm(s): 3
D: Arm Label: Rotavirus Vaccine at age 6 & 10 weeks; Type: ACTIVE_COMPARATOR; Interventions: Biological: Human Rotavirus Vaccine | Arm Label: Rotavirus vaccine at age 10 & 14 weeks; Type: EXPERIMENTAL; Interventions: Biological: Human Rotavirus Vaccine | Arm Label: Rotavirus vaccine at age 6,10,&14 weeks; Type: EXPERIMENTAL; Interventions: Biological: Human Rotavirus Vaccine | Intervention Type: BIOLOGICAL; Name: Human Rotavirus Vaccine; Assigned to Arm(s): Rotavirus Vaccine at age 6 & 10 weeks, Rotavirus vaccine at age 10 & 14 weeks, Rotavirus vaccine at age 6,10,&14 weeks

Answer: D