Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing These Drugs Either vs Insulin or vs Each Other.
Brief Summary: Since the publication in the New England Journal of Medicine (NEJM) in 2000 of the Langer's trial comparing glyburide vs insulin in the treatment of gestational diabetes mellitus (GDM), additional studies of oral agents for the treatment of GDM have been published (observational, randomized controlled trials (RCT), and trials using other drugs like metformin).

Some meta-analysis to summarize the evidence have been published: Nicholson 2009 (including 4 RCT addressing different drugs), Dhulkotia 2010 (including 6 RCT addressing different drugs, the meta-analysis combining all drugs altogether), Gui 2013 (including 5 RCT addressing metformin vs insulin).

Oral agents are increasingly used for the treatment of GDM. Investigators aim to update the evidence on RCTs comparing glyburide and metformin vs insulin or between them and summarize this evidence using meta-analysis tools. Specifically, investigators aim at producing distinct meta-analyses for each one of the three drug comparisons. This information is not available in the literature since the most recent systematic reviews specifically dealing on oral agents for the treatment of GDM have addressed a single drug comparison (Gui 2013) or have combined different drug comparisons into a single meta-analysis (Dhulkotia 2010)


Options:
A: Arm Label: Conventional Diet; Type: EXPERIMENTAL; Interventions: Other: High Carbohydrate/Low fat diet | Arm Label: Complex Carbohydrate Diet; Type: EXPERIMENTAL; Interventions: Other: Low-Carbohydrate/Higher Fat Diet | Intervention Type: OTHER; Name: Low-Carbohydrate/Higher Fat Diet; Assigned to Arm(s): Complex Carbohydrate Diet | Intervention Type: OTHER; Name: High Carbohydrate/Low fat diet; Assigned to Arm(s): Conventional Diet
B: Arm Label: Nutritional counseling & self blood glucose monitoring; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: nutritional counseling, Behavioral: self blood glucose monitoring | Arm Label: No treatment; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: nutritional counseling; Assigned to Arm(s): Nutritional counseling & self blood glucose monitoring | Intervention Type: BEHAVIORAL; Name: self blood glucose monitoring; Assigned to Arm(s): Nutritional counseling & self blood glucose monitoring
C: Arm Label: Low CHO; Type: EXPERIMENTAL; Interventions: Behavioral: Low CHO | Arm Label: High CHO; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: High CHO diet | Intervention Type: BEHAVIORAL; Name: Low CHO; Assigned to Arm(s): Low CHO | Intervention Type: DIETARY_SUPPLEMENT; Name: High CHO diet; Assigned to Arm(s): High CHO
D: Arm Label: Glyburide (Glyburide vs Insulin); Type: N/A; Interventions: Drug: Glyburide vs Insulin trials | Arm Label: Insulin (Glyburide vs Insulin); Type: N/A; Interventions: Drug: Glyburide vs Insulin trials | Arm Label: Metformin (Metformin vs Insulin); Type: N/A; Interventions: Drug: Metformin vs Insulin trials | Arm Label: Insulin (Metformin vs Insulin); Type: N/A; Interventions: Drug: Metformin vs Insulin trials | Arm Label: Metformin (Metformin vs Glyburide); Type: N/A; Interventions: Drug: Metformin vs Glyburide trials | Arm Label: Glyburide (Metformin vs Glyburide); Type: N/A; Interventions: Drug: Metformin vs Glyburide trials | Intervention Type: DRUG; Name: Glyburide vs Insulin trials; Assigned to Arm(s): Glyburide (Glyburide vs Insulin), Insulin (Glyburide vs Insulin) | Intervention Type: DRUG; Name: Metformin vs Insulin trials; Assigned to Arm(s): Insulin (Metformin vs Insulin), Metformin (Metformin vs Insulin) | Intervention Type: DRUG; Name: Metformin vs Glyburide trials; Assigned to Arm(s): Glyburide (Metformin vs Glyburide), Metformin (Metformin vs Glyburide)

Answer: D