Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomized, Multifactorial, Double-blind, Parallel-group, Dose-ranging Study of the Efficacy and Safety of Rituximab (MabThera®/Rituxan®) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis
Brief Summary: This study will assess the efficacy and safety of different treatment regimens of rituximab (MabThera®/Rituxan®), corticosteroids, and placebo, combined with methotrexate (MTX), in patients with active rheumatoid arthritis (RA).


Options:
A: Arm Label: Rituximab 1000 mg (Stage I patients); Type: EXPERIMENTAL; Interventions: Drug: Rituximab, Drug: Anti-inflammatory drugs | Arm Label: Rituximab 500 mg (Stage II patients); Type: EXPERIMENTAL; Interventions: Drug: Rituximab, Drug: Anti-inflammatory drugs | Intervention Type: DRUG; Name: Rituximab; Assigned to Arm(s): Rituximab 1000 mg (Stage I patients), Rituximab 500 mg (Stage II patients) | Intervention Type: DRUG; Name: Anti-inflammatory drugs; Assigned to Arm(s): Rituximab 1000 mg (Stage I patients), Rituximab 500 mg (Stage II patients)
B: Arm Label: Rituximab (0.5 g x 2) + Methotrexate; Type: EXPERIMENTAL; Interventions: Drug: folate, Drug: methotrexate, Drug: methylprednisolone, Drug: rituximab | Arm Label: Rituximab (1.0 g x 2) + Methotrexate; Type: EXPERIMENTAL; Interventions: Drug: folate, Drug: methotrexate, Drug: methylprednisolone, Drug: rituximab | Arm Label: Placebo + Methotrexate; Type: PLACEBO_COMPARATOR; Interventions: Drug: folate, Drug: methotrexate, Drug: methylprednisolone, Drug: placebo | Intervention Type: DRUG; Name: folate; Assigned to Arm(s): Placebo + Methotrexate, Rituximab (0.5 g x 2) + Methotrexate, Rituximab (1.0 g x 2) + Methotrexate | Intervention Type: DRUG; Name: methotrexate; Assigned to Arm(s): Placebo + Methotrexate, Rituximab (0.5 g x 2) + Methotrexate, Rituximab (1.0 g x 2) + Methotrexate | Intervention Type: DRUG; Name: methylprednisolone; Assigned to Arm(s): Placebo + Methotrexate, Rituximab (0.5 g x 2) + Methotrexate, Rituximab (1.0 g x 2) + Methotrexate | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Placebo + Methotrexate | Intervention Type: DRUG; Name: rituximab; Assigned to Arm(s): Rituximab (0.5 g x 2) + Methotrexate, Rituximab (1.0 g x 2) + Methotrexate
C: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: rituximab [MabThera/Rituxan] | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Drug: rituximab [MabThera/Rituxan] | Arm Label: 3; Type: EXPERIMENTAL; Interventions: Drug: rituximab [MabThera/Rituxan] | Intervention Type: DRUG; Name: rituximab [MabThera/Rituxan]; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: rituximab [MabThera/Rituxan]; Assigned to Arm(s): 2 | Intervention Type: DRUG; Name: rituximab [MabThera/Rituxan]; Assigned to Arm(s): 3
D: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab, Drug: corticosteroids | Arm Label: 3; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab, Drug: corticosteroids | Arm Label: 4; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab | Arm Label: 5; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab, Drug: corticosteroids | Arm Label: 6; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab, Drug: corticosteroids | Arm Label: 7; Type: PLACEBO_COMPARATOR; Interventions: Drug: methotrexate, Drug: placebo | Arm Label: 8; Type: PLACEBO_COMPARATOR; Interventions: Drug: methotrexate, Drug: corticosteroids, Drug: placebo | Arm Label: 9; Type: PLACEBO_COMPARATOR; Interventions: Drug: methotrexate, Drug: corticosteroids, Drug: placebo | Intervention Type: DRUG; Name: methotrexate; Assigned to Arm(s): 1, 2, 3, 4, 5, 6, 7, 8, 9 | Intervention Type: DRUG; Name: rituximab; Assigned to Arm(s): 1, 2, 3, 4, 5, 6 | Intervention Type: DRUG; Name: corticosteroids; Assigned to Arm(s): 2, 3, 5, 6, 8, 9 | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): 7, 8, 9

Answer: D