Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Usefulness of Nasal CPAP Treatment in Patients With a First Ever Stroke and Sleep Apnea Syndrome
Brief Summary: MAIN AIMS: to analyze the efficacy of nasal CPAP treatment in patients with ischemic first-ever stroke and Sleep Apnea Syndrome (SAS) in terms of: early neurological outcome, functional recovery, quality of life influence, stroke recurrence and survival.

SECONDARY AIMS: to evaluate the feasibility of the treatment in this type of patients at short and long time.

DESIGN: clinical randomized case-control study.

PATIENTS: younger than 75 years with a First-Ever stroke with at least one of the following criteria: snoring, observed apnea, Hypertension or Ischemic Cardiopathy.

MEASUREMENTS: protocol to define subtype stroke and parenchymatous and vascular location; sleep questionnaire (including Epworth Sleepiness Scale); Respiratory Polysomnography (RPSG). If RPSG shows an AHI \> 20, with predominant obstructive events, patients will be randomized in a CONTROL GROUP (conventional treatment) and a TREATMENT GROUP (with Nasal CPAP). Follow up for both groups at 1, 3, 12 and 24 months will include: early neurological outcome, body mass index (BMI), blood pressure (BP), functional recovery (Barthel Index/Canadian Scale), quality of life (SF36), recurrences, vital status. Nasal CPAP titration will be performed by means of an automatic system (Autoset Portable ST). Compliance will be recorded. If a negative RPSG is obtained (AHI \< 10) (NO SAS GROUP) or with AHI \< 20 (mild SAS) the usual treatment and the same follow up protocol will be established.

STATISTICS: the sample size is initially calculated in 10 patients for each group, considering this is part of a multicenter study including 8 centers. If no differences are found, depending on the statistical power the investigators will consider including more patients. The different groups will be compared for the analyzed variables with the corresponding tests.


Options:
A: Arm Label: Sleep position trainer; Type: EXPERIMENTAL; Interventions: Device: sleep position trainer | Arm Label: Oral Appliance Therapy; Type: ACTIVE_COMPARATOR; Interventions: Device: Oral Appliance Therapy | Intervention Type: DEVICE; Name: sleep position trainer; Assigned to Arm(s): Sleep position trainer | Intervention Type: DEVICE; Name: Oral Appliance Therapy; Assigned to Arm(s): Oral Appliance Therapy
B: Arm Label: SPT in patients with MAD; Type: OTHER; Interventions: Device: Sleep Position Trainer (SPT) | Intervention Type: DEVICE; Name: Sleep Position Trainer (SPT); Assigned to Arm(s): SPT in patients with MAD
C: Arm Label: Elevated body position; Type: ACTIVE_COMPARATOR; Interventions: Procedure: elevated body position | Arm Label: supine body position; Type: ACTIVE_COMPARATOR; Interventions: Procedure: supine body position | Intervention Type: PROCEDURE; Name: elevated body position; Assigned to Arm(s): Elevated body position | Intervention Type: PROCEDURE; Name: supine body position; Assigned to Arm(s): supine body position
D: Intervention Type: DEVICE; Name: Nasal CPAP (Continuous Positive Airway Pressure); Assigned to Arm(s): N/A

Answer: D