Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Role of Extended-release Niacin on Immune Activation in HIV-infected Patients Treated With Antiretroviral Therapy: a Proof-of-concept Study
Brief Summary: There are a number of powerful anti-HIV drugs, which keep the virus at undetectable levels and enable HIV-infected individuals to live longer. However, some participants taking anti-HIV drugs do not achieve an adequate CD4 recovery and remain at risk for developing AIDS and non-AIDS-related complications.

ER niacin (PrNiaspanFCT®) is an extended-released form of niacin, also known as vitamin B3. Niacin is effective in reducing cholesterol levels in the blood. This drug has been known for a long-time to treat dyslipidemia and it is used to improve favourably all the lipoprotein risk factors for artherosclerotic disease, particularly in HIV-infected patients. Recent scientific research shows that regular consumption of niacin-rich foods may also provide protection against Alzheimer's disease and age-related cognitive decline.

The purpose of this study is to find out:

1. If ER niacin combined with anti-HIV drugs, compared with anti-HIV drugs alone, could reduce T cell immune activation and enhance CD4 recovery;
2. If ER niacin can improve your quality of life and your neurocognitive functions


Options:
A: Arm Label: 4000 IU/d of D3 by mouth for 12 weeks; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: 4000 IU/d D3 over 12 weeks | Arm Label: 7000IU/d of D3 by mouth for 12 weeks; Type: EXPERIMENTAL; Interventions: Dietary Supplement: 7000 IU/d D3 over 12 weeks | Intervention Type: DIETARY_SUPPLEMENT; Name: 4000 IU/d D3 over 12 weeks; Assigned to Arm(s): 4000 IU/d of D3 by mouth for 12 weeks | Intervention Type: DIETARY_SUPPLEMENT; Name: 7000 IU/d D3 over 12 weeks; Assigned to Arm(s): 7000IU/d of D3 by mouth for 12 weeks
B: Arm Label: 1; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebos | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Behavioral: Diet, Behavioral: Exercise, Other: Placebos | Arm Label: 3; Type: EXPERIMENTAL; Interventions: Behavioral: Diet, Behavioral: Exercise, Drug: Niacin, Other: Placebos | Arm Label: 4; Type: EXPERIMENTAL; Interventions: Behavioral: Diet, Behavioral: Exercise, Drug: Fenofibrate, Other: Placebos | Arm Label: 5; Type: EXPERIMENTAL; Interventions: Behavioral: Diet, Behavioral: Exercise, Drug: Niacin, Drug: Fenofibrate | Intervention Type: BEHAVIORAL; Name: Diet; Assigned to Arm(s): 2, 3, 4, 5 | Intervention Type: BEHAVIORAL; Name: Exercise; Assigned to Arm(s): 2, 3, 4, 5 | Intervention Type: DRUG; Name: Niacin; Assigned to Arm(s): 3, 5 | Intervention Type: DRUG; Name: Fenofibrate; Assigned to Arm(s): 4, 5 | Intervention Type: OTHER; Name: Placebos; Assigned to Arm(s): 1, 2, 3, 4
C: Arm Label: ER niacin followed by ART alone; Type: OTHER; Interventions: Drug: Niacin | Arm Label: ART alone followed by ER niacin; Type: OTHER; Interventions: Drug: Niacin | Intervention Type: DRUG; Name: Niacin; Assigned to Arm(s): ART alone followed by ER niacin, ER niacin followed by ART alone | Intervention Type: DRUG; Name: Niacin; Assigned to Arm(s): ART alone followed by ER niacin, ER niacin followed by ART alone
D: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Arm Label: Multivitamins; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Multivitamins | Intervention Type: DIETARY_SUPPLEMENT; Name: Multivitamins; Assigned to Arm(s): Multivitamins | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo

Answer: C