Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Early Supplementation of Enteral Lipid With Combination of Microlipid and Fish Oil in Infants With Enterostomy
Brief Summary: Necrotizing enterocolitis (NEC) and intestinal perforation are common in premature infants. Often surgery is needed to remove the dead bowel and create an ostomy (a temporary intestinal opening on the infant's abdomen). Infants with ostomies cannot digest and absorb food well, and must receive nutrition through the blood stream, i.e. parental nutrition (PN). However, prolonged dependence on PN can severely damage the liver and gut. Therefore, giving nutrition through the gut, i.e. enteral nutrition, is the primary treatment for infants with ostomies.

Enteral fats, especially polyunsaturated fatty acids (PUFA), are most beneficial in stimulating gut mucosal adaptation, which begins 24 to 48 hours following bowel resection. In addition, the premature intestine has a rapid growth rate. It is likely that the current clinical practice of giving a relatively low-fat diet to infants with ostomies may not meet their high metabolic needs.

The investigators hypothesize that increasing dietary fat content by early supplementation with MicroLipid® (ML, n-6 PUFA) and fish oil (FO, n-3 PUFA) to preserve the proper balance of n-6 and n-3 PUFA, may (i) improve bowel adaptation and infant growth; (ii) reduce the use of PN; and (iii) prevent liver damage and/or cholestasis (jaundice) in infants with ostomies.


Options:
A: Arm Label: Dairy lipids and plant oils; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Formula containing dairy lipids and plant oils | Arm Label: Plant oils; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Formula containing plant oils | Arm Label: Dairy lipids and plant oils, DHA+ARA; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Formula containing dairy lipids and plant oils, DHA+ARA | Arm Label: Human milk; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DIETARY_SUPPLEMENT; Name: Formula containing dairy lipids and plant oils; Assigned to Arm(s): Dairy lipids and plant oils | Intervention Type: DIETARY_SUPPLEMENT; Name: Formula containing plant oils; Assigned to Arm(s): Plant oils | Intervention Type: DIETARY_SUPPLEMENT; Name: Formula containing dairy lipids and plant oils, DHA+ARA; Assigned to Arm(s): Dairy lipids and plant oils, DHA+ARA
B: Arm Label: low docosahexaenoic acid formula; Type: EXPERIMENTAL; Interventions: Dietary Supplement: low docosahexaenoic acid formula | Arm Label: medium docosahexaenoic acid formula; Type: EXPERIMENTAL; Interventions: Dietary Supplement: medium docosahexaenoic acid formula | Arm Label: high docosahexaenoic acid formula; Type: EXPERIMENTAL; Interventions: Dietary Supplement: high docosahexaenoic acid formula | Arm Label: human milk; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: breast milk | Intervention Type: DIETARY_SUPPLEMENT; Name: low docosahexaenoic acid formula; Assigned to Arm(s): low docosahexaenoic acid formula | Intervention Type: DIETARY_SUPPLEMENT; Name: medium docosahexaenoic acid formula; Assigned to Arm(s): medium docosahexaenoic acid formula | Intervention Type: DIETARY_SUPPLEMENT; Name: high docosahexaenoic acid formula; Assigned to Arm(s): high docosahexaenoic acid formula | Intervention Type: DIETARY_SUPPLEMENT; Name: breast milk; Assigned to Arm(s): human milk
C: Arm Label: Treatment; Type: EXPERIMENTAL; Interventions: Dietary Supplement: MicroLipid and fish oil | Arm Label: Control Group; Type: ACTIVE_COMPARATOR; Interventions: Other: Routine care | Intervention Type: DIETARY_SUPPLEMENT; Name: MicroLipid and fish oil; Assigned to Arm(s): Treatment | Intervention Type: OTHER; Name: Routine care; Assigned to Arm(s): Control Group
D: Arm Label: standard infant formula; Type: ACTIVE_COMPARATOR; Interventions: Other: standard infant formula | Arm Label: modified infant formula; Type: EXPERIMENTAL; Interventions: Other: modified infant formula | Arm Label: breast milk; Type: OTHER; Interventions: Other: breast milk | Intervention Type: OTHER; Name: standard infant formula; Assigned to Arm(s): standard infant formula | Intervention Type: OTHER; Name: modified infant formula; Assigned to Arm(s): modified infant formula | Intervention Type: OTHER; Name: breast milk; Assigned to Arm(s): breast milk

Answer: C