Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomised Control Trial to Compare the Effects of G-CSF and Autologous Bone Marrow Progenitor Cells Infusion on the Quality of Life and Left Ventricular Function in Patients With Heart Failure Secondary to Ischaemic Heart Disease
Brief Summary: The purpose of this study is to determine whether adult bone marrow derived stem/progenitor cells improve cardiac function and symptoms in patients with heart failure and to establish the optimal method of delivery of these cells.

Study hypotheses:

* Administration of G-CSF to patients with heart failure secondary to ischaemic heart disease will lead to an increase in circulating progenitor cells as measured by peripheral CD34+ positive cell counts
* Cardiac function and symptoms will improve in patients in whom the peripheral CD34+ counts increase in response to G-CSF administration
* Direct coronary injection of autologous bone marrow derived stem cells will confer an additional improvement in cardiac function and symptoms above that derived from G-CSF infusion alone
* Direct intramyocardial injection of autologous bone marrow derived stem cells will lead to an improvement in cardiac function and symptoms above that derived from G-CSF infusion alone


Options:
A: Intervention Type: GENETIC; Name: Cell Therapy - Autologous CD34 Positive Cells; Assigned to Arm(s): N/A
B: Arm Label: Peripheral; Type: EXPERIMENTAL; Interventions: Drug: Granulocyte-colony stimulating factor | Arm Label: Percutaneous intracoronary injection; Type: EXPERIMENTAL; Interventions: Drug: Granulocyte-colony stimulating factor, Procedure: Percutaneous intracoronary injection | Arm Label: Percutaneous intramyocardial injection; Type: EXPERIMENTAL; Interventions: Drug: Granulocyte-colony stimulating factor, Procedure: Percutaneous intramyocardial injection | Intervention Type: DRUG; Name: Granulocyte-colony stimulating factor; Assigned to Arm(s): Percutaneous intracoronary injection, Percutaneous intramyocardial injection, Peripheral | Intervention Type: PROCEDURE; Name: Percutaneous intracoronary injection; Assigned to Arm(s): Percutaneous intracoronary injection | Intervention Type: PROCEDURE; Name: Percutaneous intramyocardial injection; Assigned to Arm(s): Percutaneous intramyocardial injection
C: Arm Label: Intramyocardial injection of BM cells; Type: EXPERIMENTAL; Interventions: Other: intramyocardial injection of BM cells | Arm Label: Intramyocardial / intracoronary injection of BM cells; Type: EXPERIMENTAL; Interventions: Other: intramyocardial / intracoronary injection of BM cells | Arm Label: control; Type: OTHER; Interventions: Other: Best medical therapy | Intervention Type: OTHER; Name: intramyocardial injection of BM cells; Assigned to Arm(s): Intramyocardial injection of BM cells | Intervention Type: OTHER; Name: intramyocardial / intracoronary injection of BM cells; Assigned to Arm(s): Intramyocardial / intracoronary injection of BM cells | Intervention Type: OTHER; Name: Best medical therapy; Assigned to Arm(s): control
D: Arm Label: Intramyocardial Injections; Type: EXPERIMENTAL; Interventions: Procedure: Intramyocardial injection | Arm Label: Intracoronary Injections; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Intracoronary injection | Arm Label: Ischemic heart disease; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Intramyocardial injection | Intervention Type: PROCEDURE; Name: Intramyocardial injection; Assigned to Arm(s): Intramyocardial Injections | Intervention Type: PROCEDURE; Name: Intracoronary injection; Assigned to Arm(s): Intracoronary Injections | Intervention Type: PROCEDURE; Name: Intramyocardial injection; Assigned to Arm(s): Ischemic heart disease

Answer: B