Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomized, Open-label, Crossover Clinical Trial to Assess the Effects of Indacaterol 150 µg d.o. Compared to Tiotropium Bromide 5 µg d.o. on Dyspnea, Dynamic Pulmonary Hyperinflation and Exercise Tolerance in Patients With Moderate COPD
Brief Summary: Exercise intolerance is a major complain of patients with chronic obstructive pulmonary disease (COPD). Dynamic hyperinflation has been recognized as an important limiting factor responsible for the appearance of intolerable dyspnea during exercise. Regular treatment with long-acting bronchodilators promotes a more sustained reduction of hyperinflation and consequent symptom relief and increase in the patient's ability to overcome physical demands of daily life. Tiotropium bromide (TIO) is a new generation, long-acting anticholinergic bronchodilator that significantly improves lung function, reduces symptoms and improves exercise tolerance in patients with advanced COPD. Indacaterol is a new ultra-long duration (\>24 h) β2-agonist, which promotes sustained dilation of the bronchi with a once-daily administration. Compared to tiotropium, indacaterol provides evidence that is as effective as tiotropium for bronchodilation, as well as other clinical outcomes such as dyspnea and state of health. However, comparative effects of indacaterol versus tiotropium with regard to outcomes in tolerance, dyspnea and dynamic lung hyperinflation during exercise is scarce. We hypothesized that indacaterol and TIO are not different in terms of exercise tolerance and its determinants (dynamic hyperinflation and dyspnea).


Options:
A: Arm Label: Indacaterol first; Type: EXPERIMENTAL; Interventions: Drug: Indacaterol, Drug: Tiotropium | Arm Label: Tiotropium first; Type: EXPERIMENTAL; Interventions: Drug: Indacaterol, Drug: Tiotropium | Intervention Type: DRUG; Name: Indacaterol; Assigned to Arm(s): Indacaterol first, Tiotropium first | Intervention Type: DRUG; Name: Tiotropium; Assigned to Arm(s): Indacaterol first, Tiotropium first
B: Arm Label: Indacaterol 150 µg; Type: EXPERIMENTAL; Interventions: Drug: Indacaterol 150 μg, Drug: Placebo to tiotropium | Arm Label: Tiotropium 18 µg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Tiotropium 18 μg, Drug: Placebo to indacaterol | Intervention Type: DRUG; Name: Indacaterol 150 μg; Assigned to Arm(s): Indacaterol 150 µg | Intervention Type: DRUG; Name: Tiotropium 18 μg; Assigned to Arm(s): Tiotropium 18 µg | Intervention Type: DRUG; Name: Placebo to indacaterol; Assigned to Arm(s): Tiotropium 18 µg | Intervention Type: DRUG; Name: Placebo to tiotropium; Assigned to Arm(s): Indacaterol 150 µg
C: Arm Label: PT003 (Dose 1); Type: EXPERIMENTAL; Interventions: Drug: PT003 | Arm Label: PT003 (Dose 2); Type: EXPERIMENTAL; Interventions: Drug: PT003 | Arm Label: PT003 (Dose 3); Type: EXPERIMENTAL; Interventions: Drug: PT003 | Arm Label: PT003 (Dose 4); Type: EXPERIMENTAL; Interventions: Drug: PT003 | Arm Label: PT003 (Dose 5); Type: EXPERIMENTAL; Interventions: Drug: PT003 | Arm Label: PT001; Type: EXPERIMENTAL; Interventions: Drug: PT001 | Arm Label: PT005; Type: EXPERIMENTAL; Interventions: Drug: PT005 | Arm Label: Spiriva® Handihaler®; Type: ACTIVE_COMPARATOR; Interventions: Drug: Tiotropium inhalation powder | Intervention Type: DRUG; Name: PT003; Assigned to Arm(s): PT003 (Dose 1), PT003 (Dose 2), PT003 (Dose 3), PT003 (Dose 4), PT003 (Dose 5) | Intervention Type: DRUG; Name: PT001; Assigned to Arm(s): PT001 | Intervention Type: DRUG; Name: PT005; Assigned to Arm(s): PT005 | Intervention Type: DRUG; Name: Tiotropium inhalation powder; Assigned to Arm(s): Spiriva® Handihaler®
D: Arm Label: Aclidinium Bromide / Formoterol Fumarate; Type: EXPERIMENTAL; Interventions: Drug: Aclidinium Bromide / Formoterol Fumarate | Arm Label: Salmeterol / Fluticasone propionate; Type: ACTIVE_COMPARATOR; Interventions: Drug: Salmeterol / Fluticasone | Intervention Type: DRUG; Name: Aclidinium Bromide / Formoterol Fumarate; Assigned to Arm(s): Aclidinium Bromide / Formoterol Fumarate | Intervention Type: DRUG; Name: Salmeterol / Fluticasone; Assigned to Arm(s): Salmeterol / Fluticasone propionate

Answer: A