Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Vitamin D/Calcium Polyp Prevention Study
Brief Summary: Extensive experimental and observational data suggest that intake of calcium and of vitamin D exert protective effects on colorectal neoplasia. Building on their previous work, the investigators will investigate the chemopreventive effect of vitamin D in the large bowel, to study whether calcium with vitamin D is more effective than calcium alone, and to confirm their positive finding regarding calcium. The goal of this study is the development of chemopreventive combinations that will reduce risk of colorectal neoplasia sufficiently to permit the lengthening of surveillance intervals in most patients and to clarify important issues regarding the mechanisms of colorectal carcinogenesis and chemoprevention.


Options:
A: Arm Label: cholecalciferol; Type: EXPERIMENTAL; Interventions: Dietary Supplement: cholecalciferol | Arm Label: Ergocalciferol; Type: EXPERIMENTAL; Interventions: Dietary Supplement: ergocalciferol | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: cholecalciferol; Assigned to Arm(s): cholecalciferol | Intervention Type: DIETARY_SUPPLEMENT; Name: ergocalciferol; Assigned to Arm(s): Ergocalciferol | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo; Assigned to Arm(s): Placebo
B: Arm Label: Intervention; Type: N/A; Interventions: Behavioral: educational/counseling intervention, Behavioral: therapeutic dietary intervention | Arm Label: Control; Type: N/A; Interventions: Behavioral: therapeutic dietary intervention | Intervention Type: BEHAVIORAL; Name: educational/counseling intervention; Assigned to Arm(s): Intervention | Intervention Type: BEHAVIORAL; Name: therapeutic dietary intervention; Assigned to Arm(s): Control, Intervention
C: Arm Label: Full Factorial Placebo; Type: EXPERIMENTAL; Interventions: Drug: placebo | Arm Label: Full Factorial Calcium; Type: EXPERIMENTAL; Interventions: Drug: Calcium Carbonate | Arm Label: Full Factorial Vitamin D; Type: EXPERIMENTAL; Interventions: Drug: Vitamin D3 | Arm Label: Full Factorial Calcium Plus Vitamin D; Type: EXPERIMENTAL; Interventions: Drug: Calcium Carbonate, Drug: Vitamin D3 | Arm Label: Two Arm Placebo; Type: EXPERIMENTAL; Interventions: Drug: Calcium Carbonate | Arm Label: Two Arm Vitamin D; Type: EXPERIMENTAL; Interventions: Drug: Calcium Carbonate, Drug: Vitamin D3 | Intervention Type: DRUG; Name: Calcium Carbonate; Assigned to Arm(s): Full Factorial Calcium, Full Factorial Calcium Plus Vitamin D, Two Arm Placebo, Two Arm Vitamin D | Intervention Type: DRUG; Name: Vitamin D3; Assigned to Arm(s): Full Factorial Calcium Plus Vitamin D, Full Factorial Vitamin D, Two Arm Vitamin D | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Full Factorial Placebo
D: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: cholecalciferol (vitamin D) | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: cholecalciferol (vitamin D) | Intervention Type: DIETARY_SUPPLEMENT; Name: cholecalciferol (vitamin D); Assigned to Arm(s): 1 | Intervention Type: DIETARY_SUPPLEMENT; Name: cholecalciferol (vitamin D); Assigned to Arm(s): 2

Answer: C