Please select the eligibility criteria that correspond to the clinical trial below.
Title: Pilipino Americans Go4Health Weight Loss Program to Prevent Heart Disease
Brief Summary: This is a pilot randomized controlled trial intervention to improve lifestyle behaviors (physical activity and health diet) for Filipino Americans with type 2 diabetes on metformin. If the PilAm Go4Health intervention demonstrates potential efficacy, it may identify effective intervention strategies to significantly reduce risks for heart disease risks (i.e., metabolic syndrome) in Filipino Americans.


Options:
A: Inclusion Criteria:

* BMI ≥ 85th percentile for sex and age according to CDC growth charts
* Access to a working telephone and cell phone
* At least one parent willing and able to participate in the intervention with the subject
* Residing in predominately one household (no more than one weekend every two weeks in a secondary household)
* Medical clearance from a primary care provider or treating physician to rule out any major medical illness, disability, or disorder (e.g., liver disease, renal failure, cancer)

Exclusion Criteria:

* Intake of more than 4 cups (250 mL per cup) of water per day
* BMI ≥ 40 kg/m2
* Currently smoking (\> 1 cigarette in the past week)
* Major surgery within the previous 6 months
* Does not have a primary care provider
* Physician diagnosis of a major medical illness (e.g. diabetes)
* Previous diagnosis of an eating disorder
* Physical, mental, or cognitive handicaps that prevent participation
* Chronic use of medications that may affect study outcomes (e.g. stimulants or diuretics)
* Another member of the family (first degree relative) or household participating in the study
* A friend, classmate or coworker participating in the study with whom they have contact with one or more times per week
* Girls who are pregnant, planning to become pregnant in the next 6 months, lactating, or within 6 months postpartum
B: Inclusion Criteria:

* Age between 20-50 years;
* BMI between 28-36 kg/m2;
* Weight stabile 3 months prior to the study inclusion;
* Less than 10 hours of weekly exercise.

Exclusion Criteria:

* Diabetes
* Allergic to phenylalanine or milk
* Smoking
* Pregnancy or breast-feeding
C: Inclusion Criteria:

* Age between 20-50 years;
* BMI between 28-36 kg/m2;
* Weight stabile 3 months prior to the study inclusion;
* Less than 10 hours of weekly exercise

Exclusion Criteria:

* Diabetes
* Allergic to phenylalanine or milk
* Smoking
* Pregnancy or breast-feeding
D: Inclusion Criteria:

1. Self-identified as Filipino
2. Age \> 18 years
3. BMI for Asians \> 23 kg/m2
4. Physician diagnosed T2DM diabetes confirmed by clinical data (e.g. documentation of fasting blood glucose \>126 mg/dL or a positive oral glucose tolerance test (OGTT) \> 200 mg/dl, HbA1c \> 6.5%)
5. On metformin for T2DM

4) waist circumference: men \> 40 inches, women \> 35 inches 6) Physically inactive - most leisure time spent without much physical activity 7) No cognitive impairment per the Mini-Cog test 8) has a mobile smart phone (iPhone 4s or above, or android phone) 9) English speaking. Only one member per household allowed to enroll in the study.

Exclusion Criteria:

1. Uncontrolled T2DM
2. Glucose metabolism associated disease (Cushing's syndrome, Acromegaly, and Pheochromocytoma currently under treatment, chronic pancreatitis), 2) Thyroid disease - sub-optimally treated
3. Known medical conditions or other physical problems needing a special exercise program (e.g., prior myocardial infarction, history of angioplasty or angina, admission for hospital evaluation of chest pain, use of nitroglycerin for angina, chronic obstructive pulmonary disease, or uncontrolled hypertension)
4. Recent acute coronary syndrome, congestive heart failure
5. Currently participating in a lifestyle modification program
6. Planning a trip outside of the US during the 6-month study period
7. Known eating disorder
8. Planning a surgery in the next 7-months
9. Taking long-term antibiotics (including HIV-related agents), anti-tuberculosis agents (except isoniazid alone as prophylaxis), or prescription weight-loss drugs

Answer: D