TrialPanorama/Dataset huggingface dataset:
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Incidence of Delirium in Critically Ill Patients in a Dutch University Hospital
Brief Summary: The objective of this study is to determine the incidence of delirium in adults patients who are admitted at the critical care unit of a Dutch University Hospital.

The primary aim is to determine the incidence of delirium and to determine risk factors for this group of patients to develop a prediction model.

A secondary aim is to find differences between delirious patients and non-delirious patients on different aspects of diagnostics, treatment and care, outcome, length of stay, and inflammation.

According to Dutch law, the need to obtain informed consent was waived by the Committee on Research Involving Human Subjects (CMO) of Nijmegen for this observational study (2007/283).


Options:
A: Inclusion Criteria:

* Trauma/surgical patients admitted to the trauma/surgical ICU

Exclusion Criteria:

* sustained RASS of -4/-5 during the complete ICU admission
* presence of a condition preventing delirium assessment
* anticipated or known ICU length of stay of less than 48 hours
* taking antipsychotics prior to admission
* history of schizophrenia, epilepsy, parkinsonism, or levodopa treatment
* primary neurologic event/injury with GCS ≤ 9 during the first 48 hours of ICU
* current treatment with a continuous infusion neuromuscular blocking agent
* pregnancy
* screened positive for delirium upon admission to the ICU.
B: Inclusion Criteria:

* all adult patients (18 years and older) admitted at the critical care unit of our hospital

Exclusion Criteria:

* not able to understand Dutch
* patients with serious hearing and visibility disabilities
* mentally retarded patients
C: Inclusion Criteria:

* ICU-patients \>18 yrs old
* expected duration of stay \> 24 hrs

Exclusion Criteria:

* life expectancy of \<48 hrs on ICU admission
* necessity of prolonged deep sedation
* blindness
* inability to speak or understand dutch
D: Inclusion Criteria:

* Endotracheally intubated
* Expected time on ventilator \> 24 hours
* Age ≥ 18 years
* Informed consent

Exclusion Criteria:

* Severe head trauma where therapeutic coma is indicated
* Therapeutic hypothermia where therapeutic coma is indicated
* Status epilepticus where therapeutic coma is indicated
* Patient has participated in the study before
* Patient is transferred from another ICU with length of stay \> 48 hours
* Patient is comatose at admission
* PaO2/FiO2 ≤ 9, if sedation is necessary for oxygenation
* Patient does not speak Danish, swedish or norwegian at a reasonable level

Answer: B
Please select the eligibility criteria that correspond to the clinical trial below.
Title: The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial (AVEC Trial)
Brief Summary: The purpose of this study is to examine the effects of blood pressure medications on cognition and blood flow in hypertensive elderly patients with cognitive impairment. The hypothesis is that treatment with an angiotensin receptor blocker (ARB) or an angiotensin-converting enzyme inhibitor (ACEI) will be associated with a slower rate of further cognitive decline, improved cerebral blood flow and its regulation, and preserved physical function as compared to treatment with a diuretic (HCTZ), independent of blood pressure level.


Options:
A: Inclusion Criteria:

-Patients with essential hypertension

Exclusion Criteria:

* Severe hypertension
* History or evidence of a secondary form of hypertension
* History of myocardial infarction. Other protocol-defined inclusion exclusion criteria also apply
B: Inclusion Criteria:

* 60 years or older
* Hypertension
* Cognitive criteria: score either 10 or less out of 15 for the executive clock draw test 1 (CLOX1) or less than or equal to 1 standard deviation from the corresponding age specific mean on the immediate memory subtest

Exclusion Criteria:

* Intolerance to ACEI or ARB
* History of congestive heart failure
* History of diabetes mellitus
* History of stroke (less than 6 months)
C: Inclusion Criteria:

* Patients with essential hypertension

Exclusion Criteria:

* Severe hypertension
* History or evidence of a secondary form of hypertension
* History of myocardial infarction.
* Other protocol-defined inclusion exclusion criteria also apply.
D: Men and women hypertensive patients, ages 55 and above. A total of 36 percent were diabetics.

Answer: B
Please select the eligibility criteria that correspond to the clinical trial below.
Title: An Open Label Randomised Controlled Study to Compare the Efficacy, Safety and Tolerability of Once-monthly Administration of Subcutaneous Mircera Versus Darboepoetin Alfa for the Maintenance of Haemoglobin Levels in Renal Transplant Recipients With Chronic Renal Anaemia.
Brief Summary: This two arm study will compare the efficacy and safety of subcutaneous Mircera versus darbepoetin alfa for the maintenance of hemoglobin levels in kidney transplant recipients with chronic renal anemia. Patients currently receiving maintenance treatment with darbepoetin alfa will be randomized either to receive 4-weekly injections of Mircera with a starting dose (120, 200 or 360 micrograms subcutaneously) derived from the dose of darbepoetin alfa they were receiving in the 2 weeks preceding study start, or to stay on 2-weekly darbepoetin alfa therapy. The anticipated time on study treatment is 3-12 months, and the target sample size is 100-500 individuals.


Options:
A: Inclusion Criteria:

* Hemoglobin less than or equal to 11 g/dL
* History of Chronic Kidney Disease
* eGFR (estimated glomerular filtration rate) greater than or equal to 20 mL/min/1.73 m2 and less than or equal to 60 mL/min/1.73 m2
* Tsat (transferrin saturation) greater than 15%

Exclusion Criteria:

* Uncontrolled hypertension
* Erythropoietic protein use within 12 weeks of randomization
B: Inclusion Criteria:

* adult patients \>=18 years of age;
* type 1 or type 2 diabetes;
* stable glycemic control for \>=3 months;
* diabetic nephropathy.

Exclusion Criteria:

* women who are pregnant, breastfeeding, or unwilling to use a reliable contraceptive method;
* previous treatment with erythropoietin or other erythropoietic substance;
* nondiabetic renal disease, nephrotic syndrome;
* blood transfusion within the 3 months prior to enrollment;
* administration of any investigational drug within 30 days preceding the study start, and during the study.
C: Inclusion Criteria:

* adult patients, \> or = 18 years of age;
* kidney transplant recipients with stage 3 or stage 4 chronic kidney disease;
* functioning graft of \> 6 months and \< 10 years after kidney transplantation, with no signs of acute rejection;
* stable maintenance subcutaneous darbepoetin alfa therapy every 2 weeks.

Exclusion Criteria:

* transfusion of red blood cells during previous 2 months;
* poorly controlled hypertension;
* significant acute or chronic bleeding;
* need for dialysis therapy expected in next 6 months.
D: Inclusion Criteria:

* End stage renal disease
* Regular dialysis treatment
* Renal anemia (hemoglobin\<9.0 g/dl)
* Age \> 18 years
* Adequate iron stores (TIBC saturation \> 20%, ferritin \>200)

Exclusion Criteria:

* Signs of bleeding
* Major surgery in previous 60 days
* Hemolysis
* Other causes of anemia
* Cancer
* Inflammatory diseases

Answer: C
Please select the eligibility criteria that correspond to the clinical trial below.
Title: An Open Label Randomised Controlled Study to Compare the Efficacy, Safety and Tolerability of Once-monthly Administration of Subcutaneous Mircera Versus Darboepoetin Alfa for the Maintenance of Haemoglobin Levels in Renal Transplant Recipients With Chronic Renal Anaemia.
Brief Summary: This two arm study will compare the efficacy and safety of subcutaneous Mircera versus darbepoetin alfa for the maintenance of hemoglobin levels in kidney transplant recipients with chronic renal anemia. Patients currently receiving maintenance treatment with darbepoetin alfa will be randomized either to receive 4-weekly injections of Mircera with a starting dose (120, 200 or 360 micrograms subcutaneously) derived from the dose of darbepoetin alfa they were receiving in the 2 weeks preceding study start, or to stay on 2-weekly darbepoetin alfa therapy. The anticipated time on study treatment is 3-12 months, and the target sample size is 100-500 individuals.


Options:
A: Inclusion Criteria:

* adult patients \>=18 years of age;
* chronic renal anemia;
* regular long-term hemodialysis or peritoneal dialysis, with same mode of dialysis for \>=3 months;
* continuous iv maintenance epoetin alfa therapy with same dosing interval during previous 2 months.

Exclusion Criteria:

* transfusion of red blood cells during previous 2 months;
* poorly controlled hypertension;
* significant acute or chronic bleeding;
* active malignant disease (except non-melanoma skin cancer).
B: Inclusion Criteria:

* adult patients, \> or = 18 years of age;
* kidney transplant recipients with stage 3 or stage 4 chronic kidney disease;
* functioning graft of \> 6 months and \< 10 years after kidney transplantation, with no signs of acute rejection;
* stable maintenance subcutaneous darbepoetin alfa therapy every 2 weeks.

Exclusion Criteria:

* transfusion of red blood cells during previous 2 months;
* poorly controlled hypertension;
* significant acute or chronic bleeding;
* need for dialysis therapy expected in next 6 months.
C: Inclusion Criteria:

* Chronic renal anemia;
* Continuous intravenous maintenance erythropoietin stimulating agent (ESA) treatment during previous month;
* Regular long term hemodialysis therapy with the same mode of dialysis for \>=3 months.

Exclusion Criteria:

* Transfusion of red blood cells during previous 2 months;
* Significant acute or chronic bleeding, such as overt gastrointestinal bleeding;
* Active malignant disease (except non-melanoma skin cancer).
D: Inclusion Criteria:

* adult patients \>=18 years of age;
* chronic renal anemia;
* on dialysis (hemodialysis or peritoneal dialysis) therapy for at least 3 months;
* receiving sc epoetin alfa or beta for at least 3 months prior to the run-in period.

Exclusion Criteria:

* women who are pregnant, breastfeeding or using unreliable birth control methods;
* use of any investigational drug within 30 days preceding the run-in phase, or during the run-in or study treatment period.

Answer: B
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Prevention of Acute Voiding Difficulty After Radical Proctectomy for Rectal Cancer With Tamsulosin
Brief Summary: Various adrenergic blockers are used for acute voiding difficulty after proctectomy. Recently, a selective alpha5-adrenergic blocker, Tamsulosin has been reported to have benefit in reducing urinary symptom score and in reducing the rate of intermittent self-catheterization for patients with rectal cancer after radical proctectomy.

This study is to evaluate the efficacy of pharmacologic prevention to ameliorate the incidence of postoperative urinary dysfunction.


Options:
A: Inclusion Criteria:

* Women undergoing minimally invasive sacrocolpopexy
* Sacrocolpopexy with or without concomitant procedures
* Patients having the first start surgery of the day to standardize hospital time.

Exclusion Criteria:

* Elevated post void residual (PVR)
* Mobility problems
* Neurological conditions
* Intra-operative cystotomy or urinary tract injury
B: Inclusion Criteria:

* Older than 18 years
* Scheduled for LH for benign indication or low-grade malignancy (with or without salpingo-oophorectomy)

Exclusion Criteria:

* Concomitant procedures such as prolapse surgery, severe endometrioses and/or bowel resection
* Preoperative known urinary voiding problems (incontinence)
* Preoperative known urinary tract infection
* Patients suffering from diseases potentially associated with inability to void (e.g. MS)
* A Gravid or postpartum hysterectomy
C: Inclusion Criteria:

* Patients between 20-80 years old in general good health
* Patient willing to participate in the study
* Patient who understands and accepts to sign the informed consent form
* Patient who received proctectomy for rectal cancer located 15 cm or less of the anal verge

Exclusion Criteria:

* Documented problem of preoperative urinary dysfunction
* Any post-surgery change in patient condition which requires insertion of urinary catheter after surgery
* Past history of recurrent urinary tract infection or malignancy of urinary system organs
* Past history of surgery for urinary system organs
* Current administration of Finasteride or Dutasteride
* Liver dysfunction (SGOT or SGPT 100 IU/L or more)
* Kidney dysfunction (serum Creatinine 3mg/dl or more)
D: Inclusion Criteria:

* surgical management of pelvic organ prolapse requiring an overnight hospital admission

Exclusion Criteria:

* same day surgery
* non-ambulatory (allowed to use an assistive device)
* inability to provide informed consent, age \< 21 years
* pregnancy or desire for future pregnancy
* systematic disease known to affect bladder function (Parkinson's disease, Multiple Sclerosis, Spina Bifida, spinal cord injury or trauma and neurogenic bladder)
* known preoperative urinary retention (defined as a post-void residual \> 100mL)
* an untreated urinary tract infection at the time of surgery
* treatment at the time of surgery for urinary tract infection
* symptoms of urinary tract infection on the day of surgery

Answer: C
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Email-Based Diet and Activity Promotion in Worksites
Brief Summary: The objective of this study is to test the effectiveness of an email-based diet and physical activity intervention on increasing physical activity and fruit and vegetable consumption and decreasing intake of saturated and trans fats and added sugars.


Options:
A: Inclusion Criteria:

* BMI ≥27 kg/m2

Exclusion Criteria:

* Hypoglycemia inducing medication
* severe disease with hospital stay during the last 3 months
* smoking cessation for less then 3 months
* planned smoking cessation during study phase
* acute infects
* chronic diseases
B: Inclusion Criteria:

* Low aerobic fitness (defined for men and women in different age groups)
* Reported being sedentary or light physically active in leisure time

Exclusion Criteria:

* Participated in other interventions initiated in relation with the KRAM Study
* Were pregnant
C: Inclusion Criteria:

* regional Northern California KP employees

Exclusion Criteria:

* none
D: Inclusion Criteria:

Member of staff at the Northern Ireland Civil Service

Exclusion Criteria:

Physically active (defined as compliance with current physical activity guidelines (Pate, 1995), age \> 65 years, resting BP \> 159/99 mm Hg, total cholesterol \> 6.2 mmol•L-1, fasting blood glucose \> 7.0 mmol•L-1, body mass index (BMI) \> 34.9 kg•m-2, current cigarette smokers, individuals with cardiovascular, pulmonary or metabolic disease, pain or discomfort in the chest, dizziness or heart murmur.

individuals taking medication known to interfere with lipid metabolism, females who were pregnant or planning to become pregnant in the following five months

Answer: C
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Email-Based Diet and Activity Promotion in Worksites
Brief Summary: The objective of this study is to test the effectiveness of an email-based diet and physical activity intervention on increasing physical activity and fruit and vegetable consumption and decreasing intake of saturated and trans fats and added sugars.


Options:
A: Inclusion Criteria:

* Adults 18 years or older;
* Healthways employees based in Franklin, TN with an email account with the company;
* Provide informed consent and complete eligibility questionnaires

Exclusion Criteria:

* Current or prior use of the intervention Walkadoo
* Presence of a chronic condition that affects walking
* Projected inability to access the internet for 4 consecutive days or longer during the study
* Non-adherence to device wear during baseline
B: Inclusion Criteria:

1. Males or females 50 -70 years of age
2. Able to attend 4 measurement visits with study staff in 3 consecutive weeks
3. Spend at least 8 hours per day sitting
4. Willing and able to wear study device for 21 days
5. Able to read and write in English
6. Able to provide written informed consent

Exclusion Criteria:

1. Do not sit for at least 8 hours per day
2. Unable to attend 4 visits
3. Diagnosis of serious chronic condition that would limit the ability to stand
C: Inclusion Criteria:

* regional Northern California KP employees

Exclusion Criteria:

* none
D: Inclusion Criteria:

* Employee of Janssen Pharmaceutics Belgium
* Physically inactive lifestyle (not reaching 150 minutes of moderate-to-vigorous physical activity a week)
* PAR-Q questionnaire all answers negative, if one or more answers are positive a permission of a physician is necessary

Exclusion Criteria:

* none

Answer: C
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Email-Based Diet and Activity Promotion in Worksites
Brief Summary: The objective of this study is to test the effectiveness of an email-based diet and physical activity intervention on increasing physical activity and fruit and vegetable consumption and decreasing intake of saturated and trans fats and added sugars.


Options:
A: Inclusion Criteria:

* Adults between 21 and 65 years
* Sedentary (engaging in moderate intensity physical activity for less than 60 minutes per week)
* Working full time (35+ hours/week) at a sedentary desk dependant occupation
* Overweight (Body Mass Index \> 25.0 kg/m2 but less than 40.0 kg/2)
* Apparently healthy as assessed by a health history screening survey
* Devoid of overt complicated or acute cardiovascular, metabolic, respiratory, or neurological diseases
* Free from exercise/physical activity limitations

Exclusion Criteria:

* Adults with significant health problems exacerbated by exercise, such as uncontrolled hypertension, diabetes, orthopedic limitations, etc. will be excluded from the study. Note, with physician approval and adequate control of these health problems, these conditions will not necessarily preclude participation.
* Being unable to exercise
B: Inclusion Criteria:

* Mostly sedentary (sitting ≥ 4 hour) during the workday.
* Age ≥ 18
* Anticipated using a single computer workstation for 20 hours or more per week

Exclusion Criteria:

* Unable to stand for at least two hours per workday (two hours over the whole workday, not consecutively)
* Reported severe musculoskeletal symptoms, specifically lower extremity or lower back pain.
* Diagnosed with or under treatment for diabetes, heart disease, cancer, orthostatic hypertension, varicose vein, autoimmune disease, or other chronic diseases.
* Pregnant women
C: Inclusion Criteria:

* Employee of Glasgow Caledonian University
* Aged between 18 and 65 years
* Self-reported desk-based occupation
* Informed written consent provided
* Ability to stand unassisted

Exclusion Criteria:

* Any musculoskeletal condition which limits ability to stand regularly
D: Inclusion Criteria:

* regional Northern California KP employees

Exclusion Criteria:

* none

Answer: D
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Email-Based Diet and Activity Promotion in Worksites
Brief Summary: The objective of this study is to test the effectiveness of an email-based diet and physical activity intervention on increasing physical activity and fruit and vegetable consumption and decreasing intake of saturated and trans fats and added sugars.


Options:
A: Inclusion Criteria:

* History of cardiovascular disease
* Admission to the collaborating rehabilitation center

Exclusion Criteria:

* Technological illiteracy
* Inability to access internet at home
B: Inclusion Criteria:

* regional Northern California KP employees

Exclusion Criteria:

* none
C: Inclusion Criteria:

* Participation in a cardiovascular risk screening program
* 2 or more modifiable risk factors not on target:
* SBP \> 140 mmHg
* LDL-c \> 2.5 mmol/l
* Triglycerides \> 1.7 mmol/l
* BMI \> 25 kg/m2
* Diabetes Mellitus or fasting glucose \> 6.1 mmol/l
* Smoking

Exclusion Criteria:

* No internet access at home
* Unable to read and write Dutch
* Dependent in in daily activities (Ranking score \>=3)
* Life expectancy \< 2 years or an active malignant disease
D: Inclusion Criteria:

* Currently a patient at the General Internal Medicine Clinic at the University of North Carolina at Chapel Hill
* Moderate (6% to 20%) or high (greater than 20%) risk of CHD, as defined by current evidence and practice-based guidelines for aspirin use and cholesterol levels

Exclusion Criteria:

* Known cardiovascular disease (e.g., previous heart attack, previous coronary artery bypass graft or percutaneous coronary intervention, angina, previous transient ischemic attack \[TIA\] or stroke, peripheral vascular disease, congestive heart failure)
* Diabetes
* Low global risk of CHD (less than 6%)
* Dementia or other severe cognitive dysfunction
* Blindness
* Serious medical illness that would make the individual a poor candidate for the study (e.g., kidney failure, liver cirrhosis, HIV, non-skin cancer, any other illness for which their life expectancy is projected at less than 5 years)
* Inability to speak and understand English
* Participation in the preliminary study or in cognitive testing of intervention components

Answer: B
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Email-Based Diet and Activity Promotion in Worksites
Brief Summary: The objective of this study is to test the effectiveness of an email-based diet and physical activity intervention on increasing physical activity and fruit and vegetable consumption and decreasing intake of saturated and trans fats and added sugars.


Options:
A: Inclusion Criteria:

* regional Northern California KP employees

Exclusion Criteria:

* none
B: Inclusion Criteria:

* Employees of General Electric at work sites in the United States
* Current smokers who report having smoked at least 5 cigarettes per day for the prior 12 months
* Age 18 or older

Exclusion Criteria:

* Current use of other tobacco products, such as chewing tobacco, pipes, or cigars
* Planning to leave General Electric within the next 18 months
C: Inclusion Criteria:

* attending a training session provided by the Operating Engineers Local 324 Education Center
* greater than 18 years of age
* smoked cigarettes in the past month
* interested in participating in a program to quit smoking
D: Inclusion Criteria:

* Must be a full-time employee on a fixed term contract for at least 18 months at one of the two worksites involved in the study (Macmillan Cancer Support, Public Health England)
* Must engage in primarily desk-based work
* Must have their own desk (i.e. does not hot desk) Must be primarily office based (i.e. not working from home)
* Must have no plans to leave the organisation for an extended period (e.g. holiday \> 4 weeks or secondment) or finitely before the anticipated study end date (January 2016)

Exclusion Criteria:

* Have engaged in standing-based desk work in the month prior to the start of the study
* Have been advised against standing by a health professional; or be unable to stand
* Work for the Macmillan Support Line

Answer: A