Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Phase 2a Dose Escalation Study of the Efficacy, Safety, and Pharmacokinetics of Low Dose Primaquine for Gametocytocidal Activity Against P. Falciparum in Sub-Saharan Africa and South East Asia
Brief Summary: The purpose of this study is to evaluate the safety, efficacy, and pharmacokinetics of low single-dose primaquine for gametocidal activity against P.falciparum among adult glucose-6-phosphate dehydrogenase (G6PD)-normal malaria patients.


Options:
A: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Drug: Sulphadoxine-pyrimethamine (day 1: 500mg S&25mg P/20 kg), Drug: Artesunate (day 1,2,3: 4 mg/kg), Drug: Primaquine-base (day 3: 0.75 mg/kg) | Arm Label: 2; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo tablets | Intervention Type: DRUG; Name: Sulphadoxine-pyrimethamine (day 1: 500mg S&25mg P/20 kg); Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Artesunate (day 1,2,3: 4 mg/kg); Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Primaquine-base (day 3: 0.75 mg/kg); Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: placebo tablets; Assigned to Arm(s): 2
B: Arm Label: dihydroartemisinin-piperaquine only; Type: ACTIVE_COMPARATOR; Interventions: Drug: dihydroartemisinin-piperaquine | Arm Label: DP and 0.125 mg/kg primaquine; Type: EXPERIMENTAL; Interventions: Drug: dihydroartemisinin-piperaquine, Drug: 0.125 mg/kg Primaquine | Arm Label: DP and 0.5 mg/kg primaquine; Type: EXPERIMENTAL; Interventions: Drug: dihydroartemisinin-piperaquine, Drug: 0.5 mg/kg Primaquine | Arm Label: DP and 0.25 mg/kg primaquine; Type: EXPERIMENTAL; Interventions: Drug: dihydroartemisinin-piperaquine, Drug: 0.25 mg/kg Primaquine | Arm Label: DP and 0.0625 mg/kg primaquine; Type: EXPERIMENTAL; Interventions: Drug: dihydroartemisinin-piperaquine, Drug: 0.0625 mg/kg Primaquine | Intervention Type: DRUG; Name: dihydroartemisinin-piperaquine; Assigned to Arm(s): DP and 0.0625 mg/kg primaquine, DP and 0.125 mg/kg primaquine, DP and 0.25 mg/kg primaquine, DP and 0.5 mg/kg primaquine, dihydroartemisinin-piperaquine only | Intervention Type: DRUG; Name: 0.125 mg/kg Primaquine; Assigned to Arm(s): DP and 0.125 mg/kg primaquine | Intervention Type: DRUG; Name: 0.5 mg/kg Primaquine; Assigned to Arm(s): DP and 0.5 mg/kg primaquine | Intervention Type: DRUG; Name: 0.25 mg/kg Primaquine; Assigned to Arm(s): DP and 0.25 mg/kg primaquine | Intervention Type: DRUG; Name: 0.0625 mg/kg Primaquine; Assigned to Arm(s): DP and 0.0625 mg/kg primaquine
C: Arm Label: 3 day therapy; Type: EXPERIMENTAL; Interventions: Drug: Dihydroartemisinin piperaquine | Arm Label: 2 day therapy; Type: EXPERIMENTAL; Interventions: Drug: Dihydroartemisinin piperaquine | Intervention Type: DRUG; Name: Dihydroartemisinin piperaquine; Assigned to Arm(s): 2 day therapy, 3 day therapy
D: Arm Label: CQ; Type: EXPERIMENTAL; Interventions: Drug: Chloroquine (CQ) | Arm Label: CQ+PQ; Type: EXPERIMENTAL; Interventions: Drug: Chloroquine (CQ), Drug: primaquine (PQ) | Arm Label: CQ + AS; Type: EXPERIMENTAL; Interventions: Drug: artesunate (AS), Drug: Chloroquine (CQ) | Arm Label: SP; Type: EXPERIMENTAL; Interventions: Drug: sulphadoxine-pyrimethamine (SP) | Arm Label: SP + PQ; Type: EXPERIMENTAL; Interventions: Drug: sulphadoxine-pyrimethamine (SP), Drug: primaquine (PQ) | Arm Label: SP + AS; Type: EXPERIMENTAL; Interventions: Drug: artesunate (AS), Drug: sulphadoxine-pyrimethamine (SP) | Intervention Type: DRUG; Name: artesunate (AS); Assigned to Arm(s): CQ + AS, SP + AS | Intervention Type: DRUG; Name: sulphadoxine-pyrimethamine (SP); Assigned to Arm(s): SP, SP + AS, SP + PQ | Intervention Type: DRUG; Name: Chloroquine (CQ); Assigned to Arm(s): CQ, CQ + AS, CQ+PQ | Intervention Type: DRUG; Name: primaquine (PQ); Assigned to Arm(s): CQ+PQ, SP + PQ

Answer: B