Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A 24-Month,Randomized,Double-Blind,Two-Period Study to Evaluate the Efficacy and Safety of the Combination of Etanercept and Methotrexate and Methotrexate Alone in Subjects With Early Rheumatoid Arthritis
Brief Summary: To compare the effects of the combination of ETN and MTX to MTX alone on radiographic change and clinical disease activity in subjects with early RA over 12 months.


Options:
A: Arm Label: Group 1 (weight < 60 kg); Type: PLACEBO_COMPARATOR; Interventions: Drug: Abatacept or Placebo (both as IV & SC Solution) | Arm Label: Group 2 (weight < 60 kg); Type: PLACEBO_COMPARATOR; Interventions: Drug: Abatacept or Placebo (both as IV & SC Solution) | Arm Label: Group 3 (weight 60-100 kg); Type: PLACEBO_COMPARATOR; Interventions: Drug: Abatacept or Placebo (both as IV & SC solution) | Arm Label: Group 4 (weight > 100 kg); Type: PLACEBO_COMPARATOR; Interventions: Drug: Abatacept or Placebo (both as IV & SC solution) | Arm Label: Group 5 (weight > 100 kg); Type: PLACEBO_COMPARATOR; Interventions: Drug: Abatacept or Placebo (both as IV & SC solution) | Arm Label: Abatacept; Type: EXPERIMENTAL; Interventions: Drug: Abatacept | Intervention Type: DRUG; Name: Abatacept or Placebo (both as IV & SC Solution); Assigned to Arm(s): Group 1 (weight < 60 kg) | Intervention Type: DRUG; Name: Abatacept or Placebo (both as IV & SC Solution); Assigned to Arm(s): Group 2 (weight < 60 kg) | Intervention Type: DRUG; Name: Abatacept or Placebo (both as IV & SC solution); Assigned to Arm(s): Group 3 (weight 60-100 kg) | Intervention Type: DRUG; Name: Abatacept or Placebo (both as IV & SC solution); Assigned to Arm(s): Group 4 (weight > 100 kg) | Intervention Type: DRUG; Name: Abatacept or Placebo (both as IV & SC solution); Assigned to Arm(s): Group 5 (weight > 100 kg) | Intervention Type: DRUG; Name: Abatacept; Assigned to Arm(s): Abatacept
B: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab, Drug: corticosteroids | Arm Label: 3; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab, Drug: corticosteroids | Arm Label: 4; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab | Arm Label: 5; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab, Drug: corticosteroids | Arm Label: 6; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: rituximab, Drug: corticosteroids | Arm Label: 7; Type: PLACEBO_COMPARATOR; Interventions: Drug: methotrexate, Drug: placebo | Arm Label: 8; Type: PLACEBO_COMPARATOR; Interventions: Drug: methotrexate, Drug: corticosteroids, Drug: placebo | Arm Label: 9; Type: PLACEBO_COMPARATOR; Interventions: Drug: methotrexate, Drug: corticosteroids, Drug: placebo | Intervention Type: DRUG; Name: methotrexate; Assigned to Arm(s): 1, 2, 3, 4, 5, 6, 7, 8, 9 | Intervention Type: DRUG; Name: rituximab; Assigned to Arm(s): 1, 2, 3, 4, 5, 6 | Intervention Type: DRUG; Name: corticosteroids; Assigned to Arm(s): 2, 3, 5, 6, 8, 9 | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): 7, 8, 9
C: Arm Label: 1a; Type: ACTIVE_COMPARATOR; Interventions: Drug: Etanercept, Drug: Methotrexate | Arm Label: 1b; Type: ACTIVE_COMPARATOR; Interventions: Drug: Etanercept, Drug: Methotrexate, Drug: Placebo | Arm Label: 2a; Type: ACTIVE_COMPARATOR; Interventions: Drug: Etanercept, Drug: Methotrexate, Drug: Placebo | Arm Label: 2b; Type: ACTIVE_COMPARATOR; Interventions: Drug: Methotrexate | Intervention Type: DRUG; Name: Etanercept; Assigned to Arm(s): 1a, 1b, 2a | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): 1a, 1b, 2a, 2b | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): 1b, 2a
D: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: infliximab+azathioprine | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Drug: methylprednisolone or budesonide | Intervention Type: DRUG; Name: infliximab+azathioprine; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: methylprednisolone or budesonide; Assigned to Arm(s): 2

Answer: C