Please select the eligibility criteria that correspond to the clinical trial below.
Title: Primary Prevention of Diabetes in Children and Mothers at Increased Risk: Encourage Healthy Families.
Brief Summary: This study is a randomized intervention that will test two different approaches reflecting diverse levels of both intensity and cost, to achieving risk reduction of T2D. This will help address a critical question in the translation of primary prevention research into the public health: how much intensity (and thus cost) is required to achieve an effective outcome? In addition, the proposed study will address a critical need in diabetes prevention that has not received sufficient scholarly attention: the prevention of T2D in children. No studies of diabetes prevention similar in scope to the DPP have been performed in school-aged children; however, reducing childhood obesity is widely accepted as the primary pathway to decreasing the growing prevalence of T2D in the pediatric population.


Options:
A: Inclusion Criteria:

* Adult females, age 18 or greater
* Body-mass index of ≥ 25 kg/m2
* Is a biological mother to a child between 8 and 15 years of age (child must live with biological mom)
* Is a biological mother with past diagnosis or history of gestational diabetes, prediabetes or gave birth to a child who weighed 9 pounds or greater at delivery
* Child, ages 8 to 15 years, to biological mother meeting inclusion criteria for Adult Females

Exclusion Criteria:

* Biological mother or biological child with diagnosis of Type 1 or 2 Diabetes Mellitus
* Biological mother or biological child with current A1c \> 6.5%
* Biological mother or biological child current casual capillary blood glucose \> 220mg/dl
* Biological mother or biological child with uncontrolled hypertension (Systolic Blood Pressure (SBP) \>180 mmHg or Diastolic Blood Pressure (DBP) \>105 mmHg)
* Biological mother or biological child with heart attack, stroke, or transient ischemic attack in the past 6 months
* Biological mother or biological child with chest pain, dizziness, or fainting with physical exertion
* Biological mother or biological child with Chronic Obstructive Pulmonary Disease (COPD) or asthma requiring home oxygen
* Biological mother or biological child with cancer treatment in the last 5 years
* Biological mother or biological child with any other known condition that could limit ability to become physically active or limit life span to \<5 years
* Biological mother or biological child with history of anti-diabetic medication use (oral agents or insulin) except during past gestational diabetes
* Biological mother or biological child with self-report of any other condition associated with disordered glucose metabolism (including but not limited to):pregnancy; Cushing's syndrome; acromegaly; pheochromocytoma; chronic pancreatitis
* Biological mother or biological child with conditions or behaviors likely to affect the conduct of the study (including but not limited to): any reported developmental problems, unable or unwilling to provide informed consent/assent, unable or unwilling to communicate with study staff or engage in learning activities
B: Inclusion Criteria:

* Newborn infants with birth weight ≥ 2.500 g and gestational age ≥ 37 weeks were considered eligible for the study.

Exclusion Criteria:

* HIV-positive mothers
* Congenital malformation
* Infants referred to intensive care unit
* Multiple pregnancy.
C: Inclusion Criteria:

* Children enrolled in participating schools; entering kindergarten the year after recruitment

Exclusion Criteria:

* Children not entering kindergarten within one year of recruitment.
D: Inclusion Criteria:

Maternal/infant pairs Infant under 2 months of age Mother English speaking

Exclusion Criteria:

History of Neonatal ICU stay in infant Gestation less than 37 weeks in infant chronic disease in infant known genetic disorder in infant foster care placement in infant

Answer: A