Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Memory Aid - Computer Based Working Memory Training in Elderly With Mild Cognitive Impairment (MCI). A Randomized, Controlled Trial.
Brief Summary: Background:

Mild Cognitive Impairment (MCI) is a condition characterized by memory problems more severe than normal cognitive changes due to old age, and less severe than dementia. Reduced working memory (WM) is regarded as one of the core symptoms of an MCI-condition. Recent studies have indicated that WM can be improved trough computer based training.

Objectives:

The objective of the study is to evaluate if working memory training is effective in improving working memory in elderly MCI-patients. Further, to evaluate if cognitive training relates to structural changes in the white and gray matter of the brain, assessed by structural Magnetic Resonance Imaging. Cognitive phenotypes related to memory impairment and progression to dementia will also be investigated.

Patients and Methods:

The proposed study is a blinded, randomized and controlled trail that will include 90 elderly patients from a Memory Clinic diagnosed with MCI. The groups will be randomized to either training or a placebo version. The intervention is computerized working memory training performed for 45 minutes over 25 sessions. Neuropsychological assessment and structural MRI will be performed before, 6 and 12 months after training.

Relevance:

Currently there is no known treatment available for mild memory impairment/MCI, and few studies on specific cognitive training in MCI-patients have been performed. The proposed study has received funding from a Norwegian Health Region. If computer based training results in positive changes to memory functions in MCI patients this may represent a new, cost-effective treatment. Secondly, evaluation of training induced structural changes to grey or white matter may improve our understanding of the mechanisms behind effective cognitive interventions in MCI patients.


Options:
A: Arm Label: Intervention; Type: ACTIVE_COMPARATOR; Interventions: Device: BrainPalTM | Arm Label: Wait-List Control; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DEVICE; Name: BrainPalTM; Assigned to Arm(s): Intervention
B: Arm Label: Robot intervention; Type: EXPERIMENTAL; Interventions: Behavioral: Robot assisted cognitive training | Arm Label: Conventional intervention; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Conventional cognitive training group | Arm Label: Control group; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: Robot assisted cognitive training; Assigned to Arm(s): Robot intervention | Intervention Type: BEHAVIORAL; Name: Conventional cognitive training group; Assigned to Arm(s): Conventional intervention
C: Arm Label: Aerobic exercise; Type: EXPERIMENTAL; Interventions: Behavioral: Group 1, Behavioral: Group 2 | Arm Label: Stretching/toning; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Group 3, Behavioral: Group 4 | Arm Label: Computer-based mental activity training; Type: EXPERIMENTAL; Interventions: Behavioral: Group 1, Behavioral: Group 3 | Arm Label: Educational DVD training; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Group 2, Behavioral: Group 4 | Intervention Type: BEHAVIORAL; Name: Group 1; Assigned to Arm(s): Aerobic exercise, Computer-based mental activity training | Intervention Type: BEHAVIORAL; Name: Group 2; Assigned to Arm(s): Aerobic exercise, Educational DVD training | Intervention Type: BEHAVIORAL; Name: Group 3; Assigned to Arm(s): Computer-based mental activity training, Stretching/toning | Intervention Type: BEHAVIORAL; Name: Group 4; Assigned to Arm(s): Educational DVD training, Stretching/toning
D: Arm Label: Computerized Working Memory Training.; Type: SHAM_COMPARATOR; Interventions: Device: Computerized Working Memory Training. | Intervention Type: DEVICE; Name: Computerized Working Memory Training.; Assigned to Arm(s): Computerized Working Memory Training.

Answer: D