Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A 12-month Prospective Study of Tear Osmolarity in Contact Lens Wearers Refitted With Daily Disposable Soft Contact Lenses
Brief Summary: Tear osmolarity refers to the amount of osmotically active particles in tears and has been reported as one of the best diagnostic test for dry eye disease. Our research focused on following changes in tear osmolarity and ocular symptoms in the time-course of one year after refitting habitual contact lens wearers or fitting novices with modern daily disposable soft contact lenses. Fifty-six contact lens wearers aged (mean ± standards deviation) 26 ± 4 y/o were refitted with Silicone-Hydrogel (Delefilcon A) or Hydrogel (Omafilcon A) lenses.

Study included seven visits: baseline measurement before the study, two visits for contact lens fit and control and follow-up measurements after three, six, and 12 months of contact lens wear followed by measurements on bare eye according to the baseline scheme (post-study visit).

An impedance-based osmometer was used to collect samples from the lower tear meniscus. A standard Ocular Surface Disease Index (OSDI) questionnaire was used to monitor subject-reported ocular symptoms. Statistically significant differences were noted in tear osmolarity in the time course of the study for both eyes.

An improvement in tear osmolarity was most prevalent among subjects with high initial tear osmolarity. Low osmolarity levels were maintained after the study.

The findings of this prospective study will reveal that habitual contact lens wearers or novices may benefit from refitting with modern daily disposable soft contact lenses.


Options:
A: Arm Label: Presbyopic group - Low Add; Type: OTHER; Interventions: Device: Etafilcon A, Lotrafilcon B , Senofilcon A | Arm Label: Presbyopic group - Med Add; Type: OTHER; Interventions: Device: Etafilcon A, Lotrafilcon B , Senofilcon A | Arm Label: Presbyopic group - High Add; Type: OTHER; Interventions: Device: Etafilcon A, Lotrafilcon B , Senofilcon A | Arm Label: Non-presbyopic group; Type: OTHER; Interventions: Device: Etafilcon A, Lotrafilcon B , Senofilcon A | Intervention Type: DEVICE; Name: Etafilcon A, Lotrafilcon B , Senofilcon A; Assigned to Arm(s): Non-presbyopic group, Presbyopic group - High Add, Presbyopic group - Low Add, Presbyopic group - Med Add
B: Arm Label: Presbyope group; Type: OTHER; Interventions: Device: Etafilcon A, Device: Nelfilcon A, Device: Nesofilcon A, Device: Somofilcon A, Device: 58% Poly-HEMA | Arm Label: Non-Presbyope group; Type: OTHER; Interventions: Device: Etafilcon A, Device: Nelfilcon A, Device: Omafilcon A | Intervention Type: DEVICE; Name: Etafilcon A; Assigned to Arm(s): Non-Presbyope group, Presbyope group | Intervention Type: DEVICE; Name: Etafilcon A; Assigned to Arm(s): Presbyope group | Intervention Type: DEVICE; Name: Nelfilcon A; Assigned to Arm(s): Presbyope group | Intervention Type: DEVICE; Name: Nesofilcon A; Assigned to Arm(s): Presbyope group | Intervention Type: DEVICE; Name: Nelfilcon A; Assigned to Arm(s): Non-Presbyope group | Intervention Type: DEVICE; Name: Etafilcon A; Assigned to Arm(s): Non-Presbyope group | Intervention Type: DEVICE; Name: Somofilcon A; Assigned to Arm(s): Presbyope group | Intervention Type: DEVICE; Name: 58% Poly-HEMA; Assigned to Arm(s): Presbyope group | Intervention Type: DEVICE; Name: Omafilcon A; Assigned to Arm(s): Non-Presbyope group
C: Arm Label: ReNu Multiplus and lotrafilcon A lenses; Type: ACTIVE_COMPARATOR; Interventions: Device: lotrafilcon A contact lenses, Device: Renu Multiplus | Arm Label: Clear Care solution and lotrafilcon A lenses; Type: ACTIVE_COMPARATOR; Interventions: Device: lotrafilcon A contact lenses, Device: Clear Care | Intervention Type: DEVICE; Name: lotrafilcon A contact lenses; Assigned to Arm(s): Clear Care solution and lotrafilcon A lenses, ReNu Multiplus and lotrafilcon A lenses | Intervention Type: DEVICE; Name: Renu Multiplus; Assigned to Arm(s): ReNu Multiplus and lotrafilcon A lenses | Intervention Type: DEVICE; Name: Clear Care; Assigned to Arm(s): Clear Care solution and lotrafilcon A lenses
D: Arm Label: Hyperosmolarity group; Type: EXPERIMENTAL; Interventions: Other: Daily-disposable soft contact lens | Arm Label: Normal osmolarity; Type: EXPERIMENTAL; Interventions: Other: Daily-disposable soft contact lens | Intervention Type: OTHER; Name: Daily-disposable soft contact lens; Assigned to Arm(s): Hyperosmolarity group, Normal osmolarity

Answer: D