Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Multicenter, Controlled, Open-label Extension (OLE) Study to Assess the Long-term Safety and Efficacy of AMG 145 (Evolocumab)
Brief Summary: The primary clinical hypothesis is that long-term exposure of evolocumab (AMG 145) will be safe and well tolerated in adults with hypercholesterolemia.


Options:
A: Arm Label: Standard of Care; Type: ACTIVE_COMPARATOR; Interventions: Biological: Evolocumab, Other: Standard of care | Arm Label: Evolocumab + SOC; Type: EXPERIMENTAL; Interventions: Biological: Evolocumab | Intervention Type: BIOLOGICAL; Name: Evolocumab; Assigned to Arm(s): Evolocumab + SOC, Standard of Care | Intervention Type: OTHER; Name: Standard of care; Assigned to Arm(s): Standard of Care
B: Arm Label: Ezetimibe 10 mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ezetimibe, Drug: Placebo (for Alirocumab) | Arm Label: Alirocumab 75/Up to 150 mg Q2W; Type: EXPERIMENTAL; Interventions: Drug: Alirocumab, Drug: Placebo (for Ezetimibe) | Intervention Type: DRUG; Name: Alirocumab; Assigned to Arm(s): Alirocumab 75/Up to 150 mg Q2W | Intervention Type: DRUG; Name: Ezetimibe; Assigned to Arm(s): Ezetimibe 10 mg | Intervention Type: DRUG; Name: Placebo (for Alirocumab); Assigned to Arm(s): Ezetimibe 10 mg | Intervention Type: DRUG; Name: Placebo (for Ezetimibe); Assigned to Arm(s): Alirocumab 75/Up to 150 mg Q2W
C: Arm Label: Atorvastatin 40 mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Atorvastatin, Drug: Placebo | Arm Label: Ezetimibe 10 mg + Atorvastatin 20 mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Atorvastatin, Drug: Ezetimibe, Drug: Placebo | Arm Label: Alirocumab 75 mg/up to 150 mg + Atorvastatin 20 mg; Type: EXPERIMENTAL; Interventions: Drug: Alirocumab, Drug: Atorvastatin, Drug: Placebo | Arm Label: Atorvastatin 80 mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Atorvastatin, Drug: Placebo | Arm Label: Rosuvastatin 40 mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Rosuvastatin, Drug: Placebo | Arm Label: Ezetimibe 10 mg + Atorvastatin 40 mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Atorvastatin, Drug: Ezetimibe, Drug: Placebo | Arm Label: Alirocumab 75 mg/ up to 150 mg + Atorvastatin 40 mg; Type: EXPERIMENTAL; Interventions: Drug: Alirocumab, Drug: Atorvastatin, Drug: Placebo | Intervention Type: DRUG; Name: Alirocumab; Assigned to Arm(s): Alirocumab 75 mg/ up to 150 mg + Atorvastatin 40 mg, Alirocumab 75 mg/up to 150 mg + Atorvastatin 20 mg | Intervention Type: DRUG; Name: Atorvastatin; Assigned to Arm(s): Alirocumab 75 mg/ up to 150 mg + Atorvastatin 40 mg, Alirocumab 75 mg/up to 150 mg + Atorvastatin 20 mg, Atorvastatin 40 mg, Atorvastatin 80 mg, Ezetimibe 10 mg + Atorvastatin 20 mg, Ezetimibe 10 mg + Atorvastatin 40 mg | Intervention Type: DRUG; Name: Ezetimibe; Assigned to Arm(s): Ezetimibe 10 mg + Atorvastatin 20 mg, Ezetimibe 10 mg + Atorvastatin 40 mg | Intervention Type: DRUG; Name: Rosuvastatin; Assigned to Arm(s): Rosuvastatin 40 mg | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Alirocumab 75 mg/ up to 150 mg + Atorvastatin 40 mg, Alirocumab 75 mg/up to 150 mg + Atorvastatin 20 mg, Atorvastatin 40 mg, Atorvastatin 80 mg, Ezetimibe 10 mg + Atorvastatin 20 mg, Ezetimibe 10 mg + Atorvastatin 40 mg, Rosuvastatin 40 mg
D: Arm Label: Standard of Care; Type: ACTIVE_COMPARATOR; Interventions: Biological: Evolocumab, Drug: Standard of Care | Arm Label: Evolocumab + Standard of Care; Type: EXPERIMENTAL; Interventions: Biological: Evolocumab, Drug: Standard of Care | Intervention Type: BIOLOGICAL; Name: Evolocumab; Assigned to Arm(s): Evolocumab + Standard of Care, Standard of Care | Intervention Type: DRUG; Name: Standard of Care; Assigned to Arm(s): Evolocumab + Standard of Care, Standard of Care

Answer: A