Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Do Insulin Secretion or Genotype Pattern Predict Low Fat vs Low Carb Weight Loss Success?
Brief Summary: Genomics research is advancing rapidly, and links between genes and obesity continue to be discovered and better defined. A growing number of single nucleotide polymorphisms (SNPs) in multiple genes have been shown to alter an individual's response to dietary macronutrient composition. Based on prior genetic studies evaluating the body's physiological responses to dietary carbohydrates or fats, the investigators identified multi-locus genotype patterns with SNPs from three genes (FABP2, PPARG, and ADRB2): a low carbohydrate-responsive genotype (LCG) and a low fat-responsive genotype (LFG). In a preliminary, retrospective study (using the A TO Z weight loss study data), the investigators observed a 3-fold difference in 12-month weight loss for initially overweight women who were determined to have been appropriately matched vs. mismatched to a low carbohydrate (Low Carb) or low fat (Low Fat) diet based on their multi-locus genotype pattern. The primary objective of this study is to confirm and expand on the preliminary results and determine if weight loss success can be increased if the dietary approach (Low Carb vs. Low Fat) is appropriately matched to an individual' s genetic predisposition (Low Carb Genotype vs. Low Fat Genotype) toward those diets.


Options:
A: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Behavioral: High carbohydrate and low glycemic index (GI) diet, Behavioral: Low carbohydrate and low GI diet, Behavioral: High carbohydrate and high GI diet, Behavioral: Low carbohydrate and high GI diet | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Behavioral: High carbohydrate and low glycemic index (GI) diet, Behavioral: Low carbohydrate and low GI diet, Behavioral: High carbohydrate and high GI diet, Behavioral: Low carbohydrate and high GI diet | Arm Label: 3; Type: EXPERIMENTAL; Interventions: Behavioral: High carbohydrate and low glycemic index (GI) diet, Behavioral: Low carbohydrate and low GI diet, Behavioral: High carbohydrate and high GI diet, Behavioral: Low carbohydrate and high GI diet | Arm Label: 4; Type: EXPERIMENTAL; Interventions: Behavioral: High carbohydrate and low glycemic index (GI) diet, Behavioral: Low carbohydrate and low GI diet, Behavioral: High carbohydrate and high GI diet, Behavioral: Low carbohydrate and high GI diet | Arm Label: 5; Type: EXPERIMENTAL; Interventions: Behavioral: High carbohydrate and low glycemic index (GI) diet, Behavioral: Low carbohydrate and low GI diet, Behavioral: High carbohydrate and high GI diet, Behavioral: Low carbohydrate and high GI diet | Arm Label: 6; Type: EXPERIMENTAL; Interventions: Behavioral: High carbohydrate and low glycemic index (GI) diet, Behavioral: Low carbohydrate and low GI diet, Behavioral: High carbohydrate and high GI diet, Behavioral: Low carbohydrate and high GI diet | Arm Label: 7; Type: EXPERIMENTAL; Interventions: Behavioral: High carbohydrate and low glycemic index (GI) diet, Behavioral: Low carbohydrate and low GI diet, Behavioral: High carbohydrate and high GI diet, Behavioral: Low carbohydrate and high GI diet | Arm Label: 8; Type: EXPERIMENTAL; Interventions: Behavioral: High carbohydrate and low glycemic index (GI) diet, Behavioral: Low carbohydrate and low GI diet, Behavioral: High carbohydrate and high GI diet, Behavioral: Low carbohydrate and high GI diet | Intervention Type: BEHAVIORAL; Name: High carbohydrate and low glycemic index (GI) diet; Assigned to Arm(s): 1, 2, 3, 4, 5, 6, 7, 8 | Intervention Type: BEHAVIORAL; Name: Low carbohydrate and low GI diet; Assigned to Arm(s): 1, 2, 3, 4, 5, 6, 7, 8 | Intervention Type: BEHAVIORAL; Name: High carbohydrate and high GI diet; Assigned to Arm(s): 1, 2, 3, 4, 5, 6, 7, 8 | Intervention Type: BEHAVIORAL; Name: Low carbohydrate and high GI diet; Assigned to Arm(s): 1, 2, 3, 4, 5, 6, 7, 8
B: Arm Label: Standard Behavioral Weight Loss Intervention; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Standard Behavioral Weight Loss Intervention | Arm Label: Enhanced Weight Loss Intervention; Type: EXPERIMENTAL; Interventions: Behavioral: Enhanced Weight Loss Intervention | Intervention Type: BEHAVIORAL; Name: Standard Behavioral Weight Loss Intervention; Assigned to Arm(s): Standard Behavioral Weight Loss Intervention | Intervention Type: BEHAVIORAL; Name: Enhanced Weight Loss Intervention; Assigned to Arm(s): Enhanced Weight Loss Intervention
C: Intervention Type: BEHAVIORAL; Name: Atkins diet (extremely low carbohydrate); Assigned to Arm(s): N/A | Intervention Type: BEHAVIORAL; Name: Zone diet (low carbohydrate, high protein); Assigned to Arm(s): N/A | Intervention Type: BEHAVIORAL; Name: Ornish diet (very low fat); Assigned to Arm(s): N/A
D: Arm Label: Experimental: Low-Carbohydrate Diet; Type: EXPERIMENTAL; Interventions: Behavioral: Low-Carbohydrate Diet, Behavioral: Mobile App | Arm Label: Experimental: Low-Fat Diet; Type: EXPERIMENTAL; Interventions: Behavioral: Low-Fat Diet, Behavioral: Mobile App | Intervention Type: BEHAVIORAL; Name: Low-Carbohydrate Diet; Assigned to Arm(s): Experimental: Low-Carbohydrate Diet | Intervention Type: BEHAVIORAL; Name: Low-Fat Diet; Assigned to Arm(s): Experimental: Low-Fat Diet | Intervention Type: BEHAVIORAL; Name: Mobile App; Assigned to Arm(s): Experimental: Low-Carbohydrate Diet, Experimental: Low-Fat Diet

Answer: D