Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomized Controlled Trial of an Integrative Intervention for Non-Treatment-Seeking Meth Users
Brief Summary: In the era of HIV treatment as prevention (TasP), efforts are needed to identify evidence-based combination prevention approaches that achieve greater decreases HIV viral load among populations that are more likely to engage in HIV transmission risk behavior. Because methamphetamine-using men who have sex with men (MSM) are at greater risk for acquiring and transmitting HIV, interventions targeting stimulant use in this population of high-risk men could boost the effectiveness of TasP. At present, only conditional cash transfer approaches such as contingency management (CM) have demonstrated short- term efficacy in reducing stimulant use among substance-using MSM who are not actively seeking formal treatment. The proposed RCT will examine the efficacy of a positive affect intervention that is designed to optimize the effectiveness of CM to achieve long-term reductions in stimulant use and HIV viral load in this population. the team will examine the efficacy of this integrative intervention in a randomized controlled trial (RCT) with 110 HIV-positive, methamphetamine-using MSM. After enrolling in CM, participants will be randomized to receive either: 1) the positive affect intervention; or 2) a attention-matched control condition. Follow-up data will be collected at 3, 6, 12, and 15 months post-randomization. This RCT will provide an opportunity to examine the efficacy of an integrative intervention designed to promote long-term reductions in HIV viral load as the primary outcome. Secondary outcomes that will be examined include: increases positive affect, reductions in stimulant use, improvements in T-helper (CD4+) count, unsuppressed viral load, and decreases HIV transmission risk behavior. Identifying an efficacious intervention approach to decrease HIV viral load among methamphetamine-using MSM would substantially support the goals of the National HIV/AIDS Strategy to reduce HIV incidence and mitigate HIV-related health disparities.


Options:
A: Arm Label: Standard Care; Type: PLACEBO_COMPARATOR; Interventions: Other: Standard Care | Arm Label: Contingency management for abstinence from drugs; Type: EXPERIMENTAL; Interventions: Behavioral: contingency management | Intervention Type: BEHAVIORAL; Name: contingency management; Assigned to Arm(s): Contingency management for abstinence from drugs | Intervention Type: OTHER; Name: Standard Care; Assigned to Arm(s): Standard Care
B: Arm Label: IPS Only; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Individual Placement and Support (IPS) supported employment | Arm Label: IPS Plus Wage Supplement; Type: EXPERIMENTAL; Interventions: Behavioral: Abstinence-contingent wage supplements, Behavioral: Individual Placement and Support (IPS) supported employment | Intervention Type: BEHAVIORAL; Name: Abstinence-contingent wage supplements; Assigned to Arm(s): IPS Plus Wage Supplement | Intervention Type: BEHAVIORAL; Name: Individual Placement and Support (IPS) supported employment; Assigned to Arm(s): IPS Only, IPS Plus Wage Supplement
C: Arm Label: Standard treatment Alone; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: standard treatment | Arm Label: ST+CM; Type: EXPERIMENTAL; Interventions: Behavioral: ST+CM | Intervention Type: BEHAVIORAL; Name: ST+CM; Assigned to Arm(s): ST+CM | Intervention Type: BEHAVIORAL; Name: standard treatment; Assigned to Arm(s): Standard treatment Alone
D: Arm Label: ARTEMIS+CM; Type: EXPERIMENTAL; Interventions: Behavioral: Affect Regulation Treatment to Enhance Meth Intervention Success (ARTEMIS), Behavioral: Contingency Management (CM) | Arm Label: Attention-Control+CM; Type: PLACEBO_COMPARATOR; Interventions: Behavioral: Contingency Management (CM) | Intervention Type: BEHAVIORAL; Name: Affect Regulation Treatment to Enhance Meth Intervention Success (ARTEMIS); Assigned to Arm(s): ARTEMIS+CM | Intervention Type: BEHAVIORAL; Name: Contingency Management (CM); Assigned to Arm(s): ARTEMIS+CM, Attention-Control+CM

Answer: D