Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Double-blind, Placebo-controlled, Dose Ascending, 3-cohort Parallel Group Study to Measure the Systemic Cortisol Profile and Evaluate the Safety, Tolerability and Pharmacokinetics of GW870086X, Administered as Single Doses (12mg and 15mg), and Repeat Doses Over 3 Days (6mg, 12mg and 15mg) in Healthy Male Subjects
Brief Summary: GW870086X is a novel inhaled steroid that has an improved safety profile over other steroids but is also less potent. This study will look at higher doses to confirm the improved safety profile.


Options:
A: Arm Label: AN2728 Topical Ointment, 2%; Type: EXPERIMENTAL; Interventions: Drug: AN2728 Topical Ointment, 2% | Arm Label: Matching vehicle control; Type: PLACEBO_COMPARATOR; Interventions: Drug: Matching vehicle control | Intervention Type: DRUG; Name: AN2728 Topical Ointment, 2%; Assigned to Arm(s): AN2728 Topical Ointment, 2% | Intervention Type: DRUG; Name: Matching vehicle control; Assigned to Arm(s): Matching vehicle control
B: Arm Label: Vehicle Control (VC) Period: Vehicle Cream BID; Type: PLACEBO_COMPARATOR; Interventions: Drug: Vehicle cream | Arm Label: VC Period: Ruxolitinib 0.75% Cream BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib cream | Arm Label: VC Period: Ruxolitinib 1.5% Cream BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib cream | Arm Label: Long-Term Safety (LTS) Period: Vehicle Cream to Ruxolitinib 0.75% Cream BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib cream | Arm Label: LTS Period: Vehicle Cream to Ruxolitinib 1.5% Cream BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib cream | Arm Label: LTS Period: Ruxolitinib 0.75% Cream BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib cream | Arm Label: LTS Period: Ruxolitinib 1.5% Cream BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib cream | Intervention Type: DRUG; Name: Ruxolitinib cream; Assigned to Arm(s): LTS Period: Ruxolitinib 0.75% Cream BID, LTS Period: Ruxolitinib 1.5% Cream BID, LTS Period: Vehicle Cream to Ruxolitinib 1.5% Cream BID, Long-Term Safety (LTS) Period: Vehicle Cream to Ruxolitinib 0.75% Cream BID, VC Period: Ruxolitinib 0.75% Cream BID, VC Period: Ruxolitinib 1.5% Cream BID | Intervention Type: DRUG; Name: Vehicle cream; Assigned to Arm(s): Vehicle Control (VC) Period: Vehicle Cream BID
C: Arm Label: GW870086X; Type: OTHER; Interventions: Drug: GW870086X | Intervention Type: DRUG; Name: GW870086X; Assigned to Arm(s): GW870086X
D: Arm Label: Double Blind (DB): Vehicle BID; Type: PLACEBO_COMPARATOR; Interventions: Drug: Vehicle Cream BID | Arm Label: DB: Triamcinolone (TAC) 0.1% BID/Vehicle Cream BID; Type: ACTIVE_COMPARATOR; Interventions: Drug: Triamcinolone 0.1% Cream BID, Drug: Vehicle Cream BID | Arm Label: DB: Ruxolitinib 0.15% Once Daily (QD); Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 0.15% Cream QD | Arm Label: DB: Ruxolitinib 0.5% QD; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 0.5% Cream QD | Arm Label: DB: Ruxolitinib 1.5% QD; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 1.5% Cream QD | Arm Label: DB: Ruxolitinib 1.5% BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 1.5% Cream BID | Arm Label: Open-Label (OL): Vehicle BID to Ruxolitinib 1.5% BID; Type: PLACEBO_COMPARATOR; Interventions: Drug: Ruxolitinib 1.5% Cream BID | Arm Label: OL: TAC BID/Vehicle BID to Ruxolitinib 1.5% BID; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ruxolitinib 1.5% Cream BID | Arm Label: OL: Ruxolitinib 0.15% QD to Ruxolitinib 1.5% BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 1.5% Cream BID | Arm Label: OL: Ruxolitinib 0.5% QD to Ruxolitinib 1.5% BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 1.5% Cream BID | Arm Label: OL: Ruxolitinib 1.5% QD to Ruxolitinib 1.5% BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 1.5% Cream BID | Arm Label: OL: Ruxolitinib 1.5% BID to Ruxolitinib 1.5% BID; Type: EXPERIMENTAL; Interventions: Drug: Ruxolitinib 1.5% Cream BID | Intervention Type: DRUG; Name: Ruxolitinib 0.15% Cream QD; Assigned to Arm(s): DB: Ruxolitinib 0.15% Once Daily (QD) | Intervention Type: DRUG; Name: Ruxolitinib 0.5% Cream QD; Assigned to Arm(s): DB: Ruxolitinib 0.5% QD | Intervention Type: DRUG; Name: Ruxolitinib 1.5% Cream QD; Assigned to Arm(s): DB: Ruxolitinib 1.5% QD | Intervention Type: DRUG; Name: Ruxolitinib 1.5% Cream BID; Assigned to Arm(s): DB: Ruxolitinib 1.5% BID, OL: Ruxolitinib 0.15% QD to Ruxolitinib 1.5% BID, OL: Ruxolitinib 0.5% QD to Ruxolitinib 1.5% BID, OL: Ruxolitinib 1.5% BID to Ruxolitinib 1.5% BID, OL: Ruxolitinib 1.5% QD to Ruxolitinib 1.5% BID, OL: TAC BID/Vehicle BID to Ruxolitinib 1.5% BID, Open-Label (OL): Vehicle BID to Ruxolitinib 1.5% BID | Intervention Type: DRUG; Name: Triamcinolone 0.1% Cream BID; Assigned to Arm(s): DB: Triamcinolone (TAC) 0.1% BID/Vehicle Cream BID | Intervention Type: DRUG; Name: Vehicle Cream BID; Assigned to Arm(s): DB: Triamcinolone (TAC) 0.1% BID/Vehicle Cream BID, Double Blind (DB): Vehicle BID

Answer: C