Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: N/A
Brief Summary: A recent meta-analysis that included over 29.000 individuals found that the odds ratio (OR) of individuals with high brain reserve compared to low was 0.54 (p \< 0.0001), a risk decrease of 46%. Among the factors that influence cognitive reserve, mentally stimulating activities was the most robust factor after controlling for education, age, occupation and other potential confounds. The brain reserve effect was sustained over a median longitudinal follow-up of 7 years. It would be interesting to detect whether a complex cognitive training could show similar effects on the cognitive abilities of patients with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI) as it has been reported in previous studies based on mentally stimulating activities analysis.

The hypothesis is that a complex cognitive training alters the neural networks in both subject groups and this alteration is associated with improvement or stabilization of cognitive and non-cognitive function.

The investigator will perform a complex cognitive training program. Twenty patients with mild AD and twenty four patients with MCI will be recruited in this study. The patients will be randomised in control- and treatment groups.Additionally indirect effects on non-cognitive functions will be evaluated in caregivers of the patients.

The investigators expect that the cognitive and non-cognitive abilities will be changed during the cognitive training. The investigators also expect differences between treatment and control groups.


Options:
A: Arm Label: Robot intervention; Type: EXPERIMENTAL; Interventions: Behavioral: Robot assisted cognitive training | Arm Label: Conventional intervention; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Conventional cognitive training group | Arm Label: Control group; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: Robot assisted cognitive training; Assigned to Arm(s): Robot intervention | Intervention Type: BEHAVIORAL; Name: Conventional cognitive training group; Assigned to Arm(s): Conventional intervention
B: Arm Label: Exercises+CognitiveTraining+Vitamin D3; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Vitamin D3, Other: Exercises (E), Other: Cognitive Training (CT) | Arm Label: Exercises+CognitiveTraining+Placebo D3; Type: EXPERIMENTAL; Interventions: Other: Exercises (E), Other: Cognitive Training (CT), Other: placebo D3 | Arm Label: Exercises+Control CogTraining+Vitamin D3; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Vitamin D3, Other: Exercises (E), Other: control cognitive training | Arm Label: Exercises+Control CogTraining+Placebo D3; Type: EXPERIMENTAL; Interventions: Other: Exercises (E), Other: placebo D3, Other: control cognitive training | Arm Label: Placebo exercise+Control Cog+Placebo D3; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo D3, Other: control cognitive training, Other: Placebo exercise | Intervention Type: DIETARY_SUPPLEMENT; Name: Vitamin D3; Assigned to Arm(s): Exercises+CognitiveTraining+Vitamin D3, Exercises+Control CogTraining+Vitamin D3 | Intervention Type: OTHER; Name: Exercises (E); Assigned to Arm(s): Exercises+CognitiveTraining+Placebo D3, Exercises+CognitiveTraining+Vitamin D3, Exercises+Control CogTraining+Placebo D3, Exercises+Control CogTraining+Vitamin D3 | Intervention Type: OTHER; Name: Cognitive Training (CT); Assigned to Arm(s): Exercises+CognitiveTraining+Placebo D3, Exercises+CognitiveTraining+Vitamin D3 | Intervention Type: OTHER; Name: placebo D3; Assigned to Arm(s): Exercises+CognitiveTraining+Placebo D3, Exercises+Control CogTraining+Placebo D3, Placebo exercise+Control Cog+Placebo D3 | Intervention Type: OTHER; Name: control cognitive training; Assigned to Arm(s): Exercises+Control CogTraining+Placebo D3, Exercises+Control CogTraining+Vitamin D3, Placebo exercise+Control Cog+Placebo D3 | Intervention Type: OTHER; Name: Placebo exercise; Assigned to Arm(s): Placebo exercise+Control Cog+Placebo D3
C: Arm Label: Non-action video game training; Type: EXPERIMENTAL; Interventions: Behavioral: Experimental: Non-action video game training | Arm Label: Non-cognitive video game training; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Active Comparator: Non-cognitive video game training | Intervention Type: BEHAVIORAL; Name: Experimental: Non-action video game training; Assigned to Arm(s): Non-action video game training | Intervention Type: BEHAVIORAL; Name: Active Comparator: Non-cognitive video game training; Assigned to Arm(s): Non-cognitive video game training
D: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Behavioral: complex cognitive training | Arm Label: 2; Type: PLACEBO_COMPARATOR; Interventions: Behavioral: complex cognitive training | Intervention Type: BEHAVIORAL; Name: complex cognitive training; Assigned to Arm(s): 1, 2

Answer: D