Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Identification of Prognostic Biomarkers by fMRI of Acceptance and Commitment Therapy in Suicidal Behavior Disorder
Brief Summary: Suicidal behaviors (SB) are a major health problem in France:10,000 suicides and 220,000 suicide attempts every year. SB management is therefore a major public health issue. Recently, investigators have demonstrated the interest of acceptance and commitment therapy (ACT) as an add-on treatment to reduce intensity and severity of suicidal ideation in depressed patients having a history of suicide attempt within previous year (i.e actual SB disorder according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5)). Based on structural and functional findings, it is admitted orbitofrontal and ventral prefrontal cortices play a role in suicidal vulnerability. Interestingly, previous functional MRI (fMRI) studies have also reported the modulation of these regions by ACT in subjects suffering from chronic pain. fMRI could thus be an interesting tool to identify biomarkers of SB and its improvement by ACT.

The aim of study is to investigate neural biomarkers of ACT efficiency in patients with SB disorder. Patients having a history of SB within previous year were randomized in an ACT program (21 patients) or relaxation program (21 patients) during 7 weeks. Before and after the completion of the group, they performed 3 tasks during fMRI: implicit emotional visualization, Cyberball game, motivational task Investigators will compare cerebral activations between groups, between pre and post intervention as well as measure baseline cerebral activations associated with improvement of suicidal ideation during follow up.


Options:
A: Arm Label: Cognitive behavioral therapy (CBT) + standard care; Type: EXPERIMENTAL; Interventions: Behavioral: CBT, Behavioral: Standard care alone | Arm Label: Standard care alone; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Standard care alone | Intervention Type: BEHAVIORAL; Name: CBT; Assigned to Arm(s): Cognitive behavioral therapy (CBT) + standard care | Intervention Type: BEHAVIORAL; Name: Standard care alone; Assigned to Arm(s): Cognitive behavioral therapy (CBT) + standard care, Standard care alone
B: Arm Label: Control group; Type: OTHER; Interventions: Behavioral: Relaxation | Arm Label: Therapy ACT; Type: EXPERIMENTAL; Interventions: Behavioral: ACT therapy | Intervention Type: BEHAVIORAL; Name: Relaxation; Assigned to Arm(s): Control group | Intervention Type: BEHAVIORAL; Name: ACT therapy; Assigned to Arm(s): Therapy ACT
C: Arm Label: No text messages; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Supportive and interactive text messages; Type: EXPERIMENTAL; Interventions: Other: Supportive and interactive text messages | Intervention Type: OTHER; Name: Supportive and interactive text messages; Assigned to Arm(s): Supportive and interactive text messages
D: Arm Label: TFP; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Transference-Focused Psychotherapy | Arm Label: ECP; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: treatment by experienced community psychotherapists | Intervention Type: BEHAVIORAL; Name: Transference-Focused Psychotherapy; Assigned to Arm(s): TFP | Intervention Type: BEHAVIORAL; Name: treatment by experienced community psychotherapists; Assigned to Arm(s): ECP

Answer: B