Please select the eligibility criteria that correspond to the clinical trial below.
Title: Healthy Eating, Aerobic and Resistance Training in Youth (HEARTY) Trial
Brief Summary: The purpose of this study is to evaluate the effects of resistance training, aerobic training, and combined aerobic and resistance training on percent body fat, measured using Magnetic Resonance Imaging (MRI), in sedentary post-pubertal overweight or obese youth aged 14-18 years.


Options:
A: Inclusion Criteria:

* Children aged 6-16 years
* BMI in the overweight/obesity range according to data of Cole et al.
* Asthma diagnosis

Exclusion Criteria:

* Children with a normal weight according to data of Cole et al.
* Children without any provable asthmatic complaints
* Congenital malformations of the airways or other chronic lung diseases like cystic fibrosis (CF)
* Mental retardation or syndromes
* Heart disease
B: Inclusion Criteria:

Adolescents must: 1) be between the ages of 12 and 18 years (18 year olds must still be in high school and living at home); 2) be at or above the 85th percentile with reference to age and gender-specific Body Mass Index (BMI); 3) have at least one parent available to participate in the treatment protocol; 4) speak English; 5) agree to study participation and random assignment; and 6) be available for follow-up. In order to meet the depressed mood criterion, adolescents must have a primary diagnosis of major depressive disorder (single or recurrent), based on the KSADS-PL with a CGI-Severity ≥ 3 for depression and CDRS ≥ 36. Participants must be healthy, as established by their primary care physician, in order to participate in the exercise program -

Exclusion Criteria:

Adolescents will be excluded if: 1) they are currently receiving psychotherapy or participating in another weight loss program (only can have been in a weight loss program in the past); 2) they have a medical condition that would interfere with the prescribed dietary plan or participation in physical activity; 3) they are developmentally delayed such that the intervention materials will not be appropriate; 4) they are actively suicidal at intake; 5) they have not been on a stable dose of a psychostimulant for 6 months to ensure that a recently prescribed psychostimulant is not contributing to weight loss; 6) teens on an SSRI will not be allowed to participate due to potential effects of medication on weight loss; 7) they have a substance abuse or dependence diagnosis; or 8) they have failed a medication or psychotherapy trial for depression in the past.
C: Inclusion Criteria:

* Ages 8-16 years old
* BMI \>95th percentile for age/gender based on CDC
* Both primary caregiver/parent and child must agree to participate in the nutrition classes

Exclusion Criteria:

* endocrinopathies, including hypothyroidism and diabetes
* Psychiatric disorders that will interfere with ability to complete follow-up and adherence to protocol
* Any behavioral or psychosocial issue that will interfere with subject's completion of program, including eating disorder.
* Any use of medication (steroids, for ex.) that contributes to excess adiposity.
* Any use of pharmacological intervention for weight management, including prescription medications, over-the-counter medications, or herbal supplements.
* Any concurrent membership in a weight management program.
* Inability or unwillingness of parent to accompany the child to nutrition classes.
* Pregnancy
D: Inclusion Criteria:

* Male or female;
* aged 14-18 years,
* Tanner stage IV or above,
* waist circumference ≥75th percentile for age/gender
* body mass index ≥95th percentile for age, and gender
* AND/OR ≥85th percentile for age/gender with any of:
* Fasting glucose ≥6.0 fasting,
* 2-hour plasma glucose 7.8-11 mmol/L after 75 G oral glucose,
* fasting triglycerides \> 1.7 mmol/L,
* fasting plasma insulin \>105 pmol/L,
* HDL-C\<0.9 mmol/L, LDL-C\>3.0 mmol/L,
* total cholesterol/HDL-C \>90th percentile,
* or first-degree relative with type 2 diabetes

Exclusion Criteria:

* Participation during the previous 4 months in a regular program of exercise or aerobic sports greater than 2 times per week for at least 20 minutes per session.
* Diabetes mellitus.
* Body weight over 159 kg, and/or BMI\>45 kg/m2, exceeding capacity of DEXA and CT machines.
* Use of any performance-enhancing medication.
* Use of any medication or herbal supplement that is likely to affect body composition, lipids or glucose metabolism.
* Significant weight change (increase of ≥10%, or decrease≥5% of body weight during the two months before enrollment).
* Uncontrolled hypertension: BP \>150 mm Hg systolic or \>95 mm Hg diastolic BP in sitting position.
* Activity restrictions due to disease: unstable cardiac or pulmonary disease, significant arthritis.
* Other illness judged by the patient or study physician to make participation in this study inadvisable.
* Unwillingness/lack of availability to attend exercise and/or nutrition sessions at scheduled times and locations.
* Significant cognitive deficit resulting in inability to understand or comply with instructions.
* Pregnancy at the start of the study, or intention to become pregnant in the next year.
* Inability to communicate in English or French.
* Unwillingness of subject and/or parent/guardian to sign informed consent.

Answer: D