Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomised Cross-over Study to Compare the Effect of Formoterol Plus Tiotropium Versus Formoterol Monotherapy on Breathlessness, Dynamic Hyperinflation and Exercise Tolerance in Moderate-to-severe Stable COPD Patients
Brief Summary: The primary objective is to comparatively evaluate the isolated effects of a long-acting beta2-adrenergic (formoterol fumarate 12µg b.i.d. via Aeroliser) and combined with a long-acting anti-cholinergic (tiotropium bromide 18µg o.d via Handihaler) on breathlessness, dynamic hyperinflation and exercise tolerance in patients with advanced, but stable, chronic obstructive pulmonary disease. The study hypothesis is that combining long acting bronchodilators with different action mechanisms would promote synergistic effects on clinical outcomes.


Options:
A: Arm Label: GSK573719/GW642444 125/25; Type: EXPERIMENTAL; Interventions: Drug: GSK573719/GW642444 125/25 | Arm Label: GSK573719/GW642444 62.5/25; Type: EXPERIMENTAL; Interventions: Drug: GSK573719/GW642444 62.5/25 | Arm Label: GSK573719; Type: EXPERIMENTAL; Interventions: Drug: GSK573719 | Arm Label: tiotropium bromide; Type: ACTIVE_COMPARATOR; Interventions: Drug: tiotropium bromide | Intervention Type: DRUG; Name: GSK573719/GW642444 125/25; Assigned to Arm(s): GSK573719/GW642444 125/25 | Intervention Type: DRUG; Name: GSK573719/GW642444 62.5/25; Assigned to Arm(s): GSK573719/GW642444 62.5/25 | Intervention Type: DRUG; Name: GSK573719; Assigned to Arm(s): GSK573719 | Intervention Type: DRUG; Name: tiotropium bromide; Assigned to Arm(s): tiotropium bromide
B: Arm Label: tiotropium+olodaterol low dose; Type: EXPERIMENTAL; Interventions: Device: Respimat inhaler, Drug: tiotropium+olodaterol (low dose) | Arm Label: tiotropium+olodaterol high dose; Type: EXPERIMENTAL; Interventions: Drug: tiotropium + olodaterol (high dose), Device: Respimat inhaler | Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Device: Respimat inhaler, Drug: placebo to tiotropium+olodaterol | Intervention Type: DEVICE; Name: Respimat inhaler; Assigned to Arm(s): tiotropium+olodaterol low dose | Intervention Type: DRUG; Name: tiotropium+olodaterol (low dose); Assigned to Arm(s): tiotropium+olodaterol low dose | Intervention Type: DRUG; Name: tiotropium + olodaterol (high dose); Assigned to Arm(s): tiotropium+olodaterol high dose | Intervention Type: DEVICE; Name: Respimat inhaler; Assigned to Arm(s): tiotropium+olodaterol high dose | Intervention Type: DEVICE; Name: Respimat inhaler; Assigned to Arm(s): placebo | Intervention Type: DRUG; Name: placebo to tiotropium+olodaterol; Assigned to Arm(s): placebo
C: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Drug: Formoterol plus Placebo (Tiotropium) | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Drug: Formoterol plus Tiotropium | Intervention Type: DRUG; Name: Formoterol plus Placebo (Tiotropium); Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Formoterol plus Tiotropium; Assigned to Arm(s): 2
D: Arm Label: olodaterol (BI 1744) low and placebo; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) low, Drug: Placebo, Device: Respimat | Arm Label: olodaterol (BI 1744) low and low tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) low, Drug: low tiotropium bromide, Device: Respimat | Arm Label: olodaterol (BI 1744) low and medium tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) low, Drug: medium tiotropium bromide, Device: Respimat | Arm Label: olodaterol (BI 1744) low and high tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) low, Drug: high tiotropium bromide, Device: Respimat | Arm Label: olodaterol (BI 1744) high and placebo; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) high, Drug: Placebo, Device: Respimat | Arm Label: Olodaterol (BI 1744) high and low tio; Type: EXPERIMENTAL; Interventions: Drug: low tiotropium bromide, Drug: olodaterol (BI 1744) high, Device: Respimat | Arm Label: Olodaterol (BI 1744) high and medium tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) high, Drug: medium tiotropium bromide, Device: Respimat | Arm Label: Olodaterol (BI 1744) high and high tio; Type: EXPERIMENTAL; Interventions: Drug: olodaterol (BI 1744) high, Drug: high tiotropium bromide, Device: Respimat | Intervention Type: DRUG; Name: olodaterol (BI 1744) low; Assigned to Arm(s): olodaterol (BI 1744) low and high tio, olodaterol (BI 1744) low and low tio, olodaterol (BI 1744) low and medium tio, olodaterol (BI 1744) low and placebo | Intervention Type: DRUG; Name: low tiotropium bromide; Assigned to Arm(s): Olodaterol (BI 1744) high and low tio, olodaterol (BI 1744) low and low tio | Intervention Type: DRUG; Name: olodaterol (BI 1744) high; Assigned to Arm(s): Olodaterol (BI 1744) high and high tio, Olodaterol (BI 1744) high and low tio, Olodaterol (BI 1744) high and medium tio, olodaterol (BI 1744) high and placebo | Intervention Type: DRUG; Name: medium tiotropium bromide; Assigned to Arm(s): Olodaterol (BI 1744) high and medium tio, olodaterol (BI 1744) low and medium tio | Intervention Type: DRUG; Name: high tiotropium bromide; Assigned to Arm(s): Olodaterol (BI 1744) high and high tio, olodaterol (BI 1744) low and high tio | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): olodaterol (BI 1744) high and placebo, olodaterol (BI 1744) low and placebo | Intervention Type: DEVICE; Name: Respimat; Assigned to Arm(s): Olodaterol (BI 1744) high and high tio, Olodaterol (BI 1744) high and low tio, Olodaterol (BI 1744) high and medium tio, olodaterol (BI 1744) high and placebo, olodaterol (BI 1744) low and high tio, olodaterol (BI 1744) low and low tio, olodaterol (BI 1744) low and medium tio, olodaterol (BI 1744) low and placebo

Answer: C