Please select the eligibility criteria that correspond to the clinical trial below.
Title: Online Social Networks for Dissemination of Smoking Cessation Interventions
Brief Summary: Effective evidence-based interventions exist for smoking cessation delivered over the Internet, but consumer acceptance and adherence remains low. Scalable and efficient mechanisms to disseminate these interventions online are needed, and existing online social networks provide a potential mechanism. This is a proposal for a randomized, factorial trial of the dissemination of an evidence-based intervention through the massive Facebook social network, with the goal of determining intervention characteristics that drive viral spread.


Options:
A: Inclusion Criteria:

* 19 years of age or older
* Current smoker (at least one puff in the last 30 days)
* Regular (at least weekly) email/internet access
* Can read and speak English
* Can communicate well enough to provide meaningful responses to the screening questions and informed consent
* Well enough to participate (provide meaningful responses to the screening questions and informed consent)
* On standard or contact isolation only
* Cognitively able to participate (to provide meaningful responses to the screening questions and informed consent)
* Does not have another household member participating in this study

Exclusion Criteria:

* Under age 19
* Non-smoker
* Cannot read and speak English
* No email/internet access
* Cannot communicate well enough to provide meaningful responses to the screening questions and informed consent
* Too ill to participate (provide meaningful responses to the screening questions and informed consent)
* On isolation precautions other than standard or contact
* Cognitively unable to participate (to provide meaningful responses to the screening questions and informed consent)
* Has another household member participating in this study
B: Inclusion Criteria:

* Member of Group Health Cooperative
* Currently Smoking at Least 5 Cigarettes/Day
* Access to Email and the Internet
* Read and Write English
* 18 years or older
* Not currently receiving tobacco cessation treatment
* Capable of participating in online and phone surveys

Exclusion Criteria:

* Persons will be excluded if they do not meet above criteria
C: Inclusion Criteria:

* Facebook user
* Age 18 years or older
* Entered UbiQUITous Facebook Application
* Confirms smoker status
* U.S. resident

Exclusion Criteria:

* Non-smoker
* Under 18 years old
* Non-U.S. resident
* Non-Facebook advertisement point of entry
D: Inclusion Criteria:

* An invited member of Group Health, a health care system in the Pacific Northwest
* Plan to remain enrolled in Group Health for the next 6 months
* aged 18 - 65
* Eligible for smoking cessation treatment through Group Health insurance coverage
* smoke \>= 10 cigs a day
* speak and read in English
* willing to use varenicline and no contraindications for this medication
* ready to quit smoking
* have a smart phone with internet access
* willing to receive study texts and emails
* receive care at a Group Health clinic and have electronic medical records in this system
* fill prescriptions through the Group Health pharmacy
* agree to use birth control while taking study medication, if there is a risk of pregnancy

Exclusion Criteria:

* lifetime history of dementia
* psychosis or bipolar disorder based on self-report or medical record review
* hearing, comprehension or visual limitations that preclude full study participation
* current use of other forms of tobacco
* any medical contraindication for varenicline use
* documented history of suicidal ideation/intent

Answer: C