Please select the eligibility criteria that correspond to the clinical trial below.
Title: PathMate2: The Impact of Health Information System Services on the Effects of Therapy in Overweight Teenagers
Brief Summary: Randomised controlled trial in overweight adolescents using a health App.


Options:
A: Inclusion Criteria:

* 18 through 60 years old
* BMI between 27 - 45 kg/m2
* \< 350 lbs
* Weight stable (no loss or gain \>25 lbs. for the past 6 months)
* Interested in losing weight and not enrolled in a formal weight loss program or taking medications or supplements that may cause weight change
* Own a Smartphone and be willing to install the SMART App
* Reside in the Chicago area for the duration of their participation (12 months)

Exclusion Criteria:

* Unstable medical conditions (uncontrolled hypertension, diabetes - uncontrolled or treated with insulin, uncontrolled hypothyroidism, unstable angina pectoris, transient ischemic attack, cancer undergoing active treatment, cerebrovascular accident or myocardial infarction within the past six months, or Crohn's disease)
* Pregnancy, lactation, or intended pregnancy
* Active suicidal ideation, anorexia, bulimia, binge eating disorder, current substance abuse or dependence (besides nicotine dependence)
* Require assistive device for mobility or current condition that may limit or prevent participation in moderate activity
* Use of pacemaker or other electrical implanted device
* History of bariatric (or LapBand) surgery, or considering or currently on a wait-list for bariatric or LapBand surgery
* May not live with a current or past SMART study participant
B: Inclusion Criteria:

* obesity, BMI \> P. 97 (Jenni et al., 2011) or overweight, BMI \>P.90, plus risk factors or co-morbidity
* ability and parent's permission to use pre-configured study smartphones handed out to the children
* readiness to use the personal smartphone number and to spend the sum allocated exclusively for the study SMS during the 6 months of intervention

Exclusion Criteria:

* major somatic or psychiatric disease without adequate treatment,
* weight-relevant medication (antiepileptic drugs, methylphenhydate and similar medication),
* inability or lack of parent's or caregivers' permission to use a study smartphone with a mobile phone contract,
* lack of informed consent from children and parents and
* undue consumption of the amount allocated for study SMS for non-study purposes,
* overuse of smartphone e.g. without night beak for at least 8 hours.
C: Inclusion Criteria:

* age: 50-75y old
* BMI ≥25 and ≤45 kg/m2
* a diagnosis of prediabetes AND/OR fasting glucose 100 mg/dL and/or HbA1c 5.7% OR Type 2 Diabetes diet-controlled and/or treated with metformin AND meeting 2 or more of the following metabolic syndrome criteria:

  * diagnosis of hypertension on stable medication regimen
  * blood pressure \>120/\>80 mmHg
  * A diagnosis of dyslipidemia on stable regimen
  * triglycerides 150 mg/dL
  * HDL cholesterol men \<40 mg/dL and women \<50 mg/dL
  * waist circumference men: \>102 cm (\>40 in); women \>88 cm (\>35 in)
* in possession of a smart phone (iPhone or Android)
* 70% of days with logging adherence (2 or more log entries/day separated by at least 5h)
* Sleep duration 6-h, with habitual self-reported wake up time \>5AM and before 11 AM and average self reported bed time \<2AM
* habitually eat breakfast
* with weight stability within 5% of screening for the last 3 months
* English speaking (the App has not yet been translated)
* must live in the New York City metro area

Exclusion criteria:

* sleep disorder, e.g. known obstructive sleep apnea (OSA) on CPAP, severe OSA with apnea-hypopnea index \>30 events/h, significant daytime symptoms of OSA, periodic limb movements of sleep, narcolepsy, current shift work or in last 6-mo, travel more than 1 time zone during intervention; severe insomnia with score 15 on Insomnia Severity Index
* significant organ system dysfunction/disease: severe pulmonary, kidney or cardiovascular disease; evidence of active illness (e.g., fever)
* history of seizure disorder
* previous bariatric surgery or on weight loss medication
* history of or current significant food intake or psychiatric disorder
* use of dietary supplements and/or medications known to affect sleep, circadian rhythms or metabolic function
* smoking tobacco or using illegal or recreational drugs
* consume excessive alcohol (women: \>14 drinks/wk; men: \>21 drinks/wk)
* anemia (hemoglobin \<10 g/dl and hematocrit \<30%)
* have conditions that render individual unable to complete all testing procedures \[e.g., unable to stay overnight or frequent travel across 1 time zones\]
* extreme early and late chronotypes (\> 2AM bed time and wake up time before 5AM and \> 11AM)
* severe food allergies
* unwilling/unable to provide informed consent
D: Inclusion Criteria:

* English-speaking adults aged 18+ years
* High-risk primary prevention: BMI 35+ and prediabetes (including hx of gestational diabetes) and/or metabolic syndrome
* Secondary prevention: BMI 30+ and type 2 diabetes and/or cardiovascular disease
* Able and willing to provide written informed consent

Exclusion Criteria:

* Medical determination that the study is inappropriate or unsafe for the patient
* Type 1 diabetes
* Safety concerns related to significant physical or mental health issues or life expectancy of less than 12 months
* Currently pregnant or lactating
* No regular telephone or broadband Internet access or otherwise unable to participate in the intervention

Answer: B