Please select the eligibility criteria that correspond to the clinical trial below.
Title: Acupuncture in Chronic Migraine: A Randomized Controlled Trial
Brief Summary: The aim of this study was to investigate the efficacy and tolerance of acupuncture treatment compared with pharmacologic treatment in patients with chronic migraines.Besides, the investigators tested whether the clinical effects of acupuncture in chronic migraine prophylaxis are mediated by changes of the plasma CGRP (Calcitonin gene-related peptide).


Options:
A: Inclusion criteria:

Diagnosis of Irritable Bowel Syndrome based on Rome II criteria, including at least 12 weeks of abdominal discomfort or pain in the last 12 months with at least 2 of the following features:

* Relief with defecation
* Onset associated with a change in stool frequency
* Onset associated with a change in form/appearance of stool

Exclusion criteria:

* History of severe or intractable IBS, defined as continuous, unremitting and several abdominal pain greater than 12 hours/day
* Previous acupuncture treatment
* Concurrent diagnosis of any bowel disturbance that would interfere with the assessment or safety of the study
* History of laxative abuse
* Previous abdominal surgery (uncomplicated appendectomy, hysterectomy or cholecystectomy at least 6 months prior to entry acceptable)
* History of metabolic or inflammatory disease that may affect bowel motility, eg.g., inflammatory bowel disease, diabetes mellitus, sarcoidosis
* Other significant illness as determined by Investigator
* History of drug or alcohol abuse w/in 2 years;
* Insufficient knowledge of English to complete self-assessments to participate in study
B: Inclusion Criteria:

* Age 18 to 75 years old
* Patients were required to have a diagnosis of chronic migraine with or without medication overuse that satisfied the ICHD-2 criteria during the last 3 months prior to trial entry, with an established migraine history for at least 1 year.

Exclusion Criteria:

* Patients did not fulfill the criteria of ≧ 15 days or response to triptans or ergots on at least 8 days in prospective baseline periods .
* The presence of headaches other than chronic migraine (such as another primary chronic headache or any secondary headache).
* Migraine prophylaxis agents during last 3 months including β-blockers, anti-depressants, calcium channel blockers, anti-epileptic agents or cycle-modulating hormonal drugs.
* Migraine onset after age 50 or the age at onset of CM \> 60 years.
* History of hepatic disorder, nephrolithiasis or other severe illness.
* Cognitive impairment interfering with the subject's ability to follow instructions and describe symptoms.
* Prior fearful experience of acupuncture.
* Bleeding diathesis or anticoagulation.
* Pregnant or nursing.
C: Inclusion Criteria:

1. Age of a subject is older than 18 and is younger than 65.(The subject is younger than 50 when he was ill for the first time.)
2. Consistent with the diagnostic criteria of Premonitory Migraine and Non- Premonitory Migraine.
3. Attacks of migraine are equal to or more than 2 times in the last three months.
4. With more than one year history of migraine
5. Informed consent is signed by a subject or his lineal relation.

Exclusion Criteria:

1. With serious protopathy or disease of cardiovascular, liver, renal,gastrointestinal, hematological systems and so on.
2. Psychotic，patients with allergic constitution or easily getting infected or bleeding.
3. Patients have used drugs for preventing migraine in the last four weeks.
4. Pregnant women or women in lactation.
D: Inclusion Criteria:

* Age of a subject is between 18 and 65 years old(initially occured beneath the age of 50), male or female;
* in accordance with diagnosis of migraine without aura in International Classification of Headache Disorders, ICHD-2, by IHS;
* 2 to 8 times attack per month in recent 3 months, with each period beyond 15 days;
* with migraine history for over 1 year;
* be able and willing to finish the headache diary in baseline ;
* informed consent form must be signed by patient or lineal relative;

Exclusion Criteria：

* Patients who are unconscious, psychotic.
* Patients with aggravating tumor and other serious consumptive disease, and who are subject to infection and bleeding.
* With serious primary illness or disease of cardiovascular, liver, renal, gastrointestinal, hematological systems and so on.
* Pregnant women or women in lactation.

Answer: B