Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A One Year Prospective, Randomized, Double Blind Interventional Study to Assess Tolerability, Quality of Life and Immunomodulation With Interferon Beta Combined With Vitamin D in Patients With Relapsing Remitting Multiple Sclerosis
Brief Summary: The investigators hypothesize that vitamin D supplementation may ameliorate interferon beta-induced flu-like symptoms, owing to reduced release and activity of the cytokines that are in correlation with this adverse event. Vitamin D supplementation may also positively affect injection site reactions due to its immunomodulatory effects. Vitamin D may also augment the therapeutic efficacy of interferon beta among multiple sclerosis (MS) patients. Vitamin D intake may influence melatonin levels of MS patients as they share the same nuclear receptor.


Options:
A: Arm Label: VigantOL® oil; Type: EXPERIMENTAL; Interventions: Drug: VigantOL oil plus interferon beta-1a (Rebif) | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo plus interferon beta-1a (Rebif) | Arm Label: Rebif; Type: EXPERIMENTAL; Interventions: Biological: Interferon beta-1a (Rebif®) alone | Intervention Type: DRUG; Name: VigantOL oil plus interferon beta-1a (Rebif); Assigned to Arm(s): VigantOL® oil | Intervention Type: DRUG; Name: Placebo plus interferon beta-1a (Rebif); Assigned to Arm(s): Placebo | Intervention Type: BIOLOGICAL; Name: Interferon beta-1a (Rebif®) alone; Assigned to Arm(s): Rebif
B: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: Colecalciferol | Arm Label: 2; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo capsules | Intervention Type: DRUG; Name: Colecalciferol; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Placebo capsules; Assigned to Arm(s): 2
C: Arm Label: Healthy control - 5,000 IU vitamin D; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: 5000IU vitamin D | Arm Label: Healthy control - 10,000 IU vitamin D; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: 10000IU vitamin D | Arm Label: CIS - placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Arm Label: CIS - 5,000 IU vitamin D; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: 5000IU vitamin D | Arm Label: CIS - 10,000 IU vitamin D; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: 10000IU vitamin D | Arm Label: Healthy control - placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: 5000IU vitamin D; Assigned to Arm(s): CIS - 5,000 IU vitamin D, Healthy control - 5,000 IU vitamin D | Intervention Type: DIETARY_SUPPLEMENT; Name: 10000IU vitamin D; Assigned to Arm(s): CIS - 10,000 IU vitamin D, Healthy control - 10,000 IU vitamin D | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): CIS - placebo, Healthy control - placebo
D: Arm Label: High dose vitamin D; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Vitamin D3 | Arm Label: Low dose vitamin D; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Vitamin D3 | Intervention Type: DIETARY_SUPPLEMENT; Name: Vitamin D3; Assigned to Arm(s): High dose vitamin D | Intervention Type: DIETARY_SUPPLEMENT; Name: Vitamin D3; Assigned to Arm(s): Low dose vitamin D

Answer: D