Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Can Exercise Improve Cancer Associated Cognitive Dysfunction?
Brief Summary: Following chemotherapy, some breast cancer survivors report alterations in their ability to remember, concentrate, or think, which can have significant emotional, psychological, and economic impact on their lives. Survivors have also reported feeling frustrated by the response of the medical community, who either may not acknowledge their symptoms or have no treatment options to suggest. Exercise may be a promising treatment, as improvements in cognitive function with exercise have been demonstrated in older adults and other clinical populations.

The investigators will recruit women who have completed chemotherapy for breast cancer (within the past 2 years) and report cognitive changes. Women will be randomly assigned to either a 24-week aerobic exercise intervention or delayed exercise control (offered the same exercise program following the study). At the start and end of the study the investigators will measure: i) performance on four standard neuropsychological tests that measure working memory, learning, and problem solving; ii) a questionnaire on cognitive function and its impact on quality of life; iii) functional magnetic resonance imaging (fMRI) during two of the standard neuropsychological tests which provides information on how the brain is working during the tests.

To knowledge of the investigators this is the first study to examine the effect of an exercise intervention on cognitive function in breast cancer survivors. In addition, the use of fMRI imaging is a new way to approach this research question, and may be more sensitive to change than traditional measures of cognitive function.


Options:
A: Arm Label: Delayed exercise control; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Exercise; Type: EXPERIMENTAL; Interventions: Behavioral: Exercise | Intervention Type: BEHAVIORAL; Name: Exercise; Assigned to Arm(s): Exercise
B: Arm Label: Brain Training; Type: EXPERIMENTAL; Interventions: Behavioral: Brain Training Program | Arm Label: Brain Health; Type: EXPERIMENTAL; Interventions: Behavioral: Brain Health Program | Arm Label: Control; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: Brain Training Program; Assigned to Arm(s): Brain Training | Intervention Type: BEHAVIORAL; Name: Brain Health Program; Assigned to Arm(s): Brain Health
C: Arm Label: ketogenic diet and transient fasting; Type: EXPERIMENTAL; Interventions: Dietary Supplement: calorie-restricted ketogenic diet and transient fasting | Arm Label: standard nutrition; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: standard nutrition | Intervention Type: DIETARY_SUPPLEMENT; Name: calorie-restricted ketogenic diet and transient fasting; Assigned to Arm(s): ketogenic diet and transient fasting | Intervention Type: DIETARY_SUPPLEMENT; Name: standard nutrition; Assigned to Arm(s): standard nutrition
D: Arm Label: WBRT+Memantine; Type: EXPERIMENTAL; Interventions: Drug: Memantine, Radiation: Whole brain radiation therapy | Arm Label: WBRT+Placebo; Type: ACTIVE_COMPARATOR; Interventions: Other: Placebo, Radiation: Whole brain radiation therapy | Intervention Type: DRUG; Name: Memantine; Assigned to Arm(s): WBRT+Memantine | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): WBRT+Placebo | Intervention Type: RADIATION; Name: Whole brain radiation therapy; Assigned to Arm(s): WBRT+Memantine, WBRT+Placebo

Answer: A