TrialPanorama/Dataset huggingface dataset:
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Treatments for Fathers With Attention Deficit/Hyperactivity Disorder (ADHD) and Their At-Risk Children (Fathers Too)
Brief Summary: In contrast to mothers with Attention Deficit/Hyperactivity Disorder (ADHD), the impact of paternal ADHD in families and children with ADHD symptoms has not been studied, despite the prevalence of ADHD in males. Thus, the investigators do not know the feasibility, impact on treatment on the family and child, and effects of treating fathers relative to mothers with ADHD. Paternal ADHD is associated with negative parenting and child conduct problems.

The investigators hypothesize that successfully treating parental ADHD in fathers will have a beneficial effects on the family that will extend to the child. Specifically, the investigators believe that stimulant medication ((Lisdexamfetamine (LDX) or a different ADHD medication if poor response to LDX) with fathers will reduce father's ADHD symptoms and improve parenting. Effects of stimulant treatment of fathers will be compared to Behavioral Parent Training (BPT) on parenting, and paternal and child outcomes in fathers with ADHD who have children between the ages of 3 -8.

As in the investigator's previous work, the investigators will bank paternal and child DNA and RNA for later examination of pharmacogenetic and epigenetic effects (i.e. RNA) of stimulant response.


Options:
A: Arm Label: Methylphenidate; Type: EXPERIMENTAL; Interventions: Drug: Methylphenidate | Arm Label: Matching Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Matching Placebo | Intervention Type: DRUG; Name: Methylphenidate; Assigned to Arm(s): Methylphenidate | Intervention Type: OTHER; Name: Matching Placebo; Assigned to Arm(s): Matching Placebo
B: Arm Label: Adhansia XR; Type: EXPERIMENTAL; Interventions: Drug: Adhansia XR | Arm Label: Concerta; Type: ACTIVE_COMPARATOR; Interventions: Drug: Concerta | Intervention Type: DRUG; Name: Adhansia XR; Assigned to Arm(s): Adhansia XR | Intervention Type: DRUG; Name: Concerta; Assigned to Arm(s): Concerta
C: N/A
D: Arm Label: Medication Arm; Type: ACTIVE_COMPARATOR; Interventions: Drug: Vyvanse, Drug: Methylphenidate | Arm Label: Behavioral Parent Training Arm; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Behavioral Parent Training | Intervention Type: DRUG; Name: Vyvanse; Assigned to Arm(s): Medication Arm | Intervention Type: BEHAVIORAL; Name: Behavioral Parent Training; Assigned to Arm(s): Behavioral Parent Training Arm | Intervention Type: DRUG; Name: Methylphenidate; Assigned to Arm(s): Medication Arm

Answer: D
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Treatments for Fathers With Attention Deficit/Hyperactivity Disorder (ADHD) and Their At-Risk Children (Fathers Too)
Brief Summary: In contrast to mothers with Attention Deficit/Hyperactivity Disorder (ADHD), the impact of paternal ADHD in families and children with ADHD symptoms has not been studied, despite the prevalence of ADHD in males. Thus, the investigators do not know the feasibility, impact on treatment on the family and child, and effects of treating fathers relative to mothers with ADHD. Paternal ADHD is associated with negative parenting and child conduct problems.

The investigators hypothesize that successfully treating parental ADHD in fathers will have a beneficial effects on the family that will extend to the child. Specifically, the investigators believe that stimulant medication ((Lisdexamfetamine (LDX) or a different ADHD medication if poor response to LDX) with fathers will reduce father's ADHD symptoms and improve parenting. Effects of stimulant treatment of fathers will be compared to Behavioral Parent Training (BPT) on parenting, and paternal and child outcomes in fathers with ADHD who have children between the ages of 3 -8.

As in the investigator's previous work, the investigators will bank paternal and child DNA and RNA for later examination of pharmacogenetic and epigenetic effects (i.e. RNA) of stimulant response.


Options:
A: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: Methylphenidate Transdermal System | Intervention Type: DRUG; Name: Methylphenidate Transdermal System; Assigned to Arm(s): 1
B: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: CONCERTA (methylphenidate HCl) / Placebo | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Drug: Placebo/ CONCERTA (methylphenidate HCl) | Intervention Type: DRUG; Name: Placebo/ CONCERTA (methylphenidate HCl); Assigned to Arm(s): 2 | Intervention Type: DRUG; Name: CONCERTA (methylphenidate HCl) / Placebo; Assigned to Arm(s): 1
C: Arm Label: Medication Arm; Type: ACTIVE_COMPARATOR; Interventions: Drug: Vyvanse, Drug: Methylphenidate | Arm Label: Behavioral Parent Training Arm; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Behavioral Parent Training | Intervention Type: DRUG; Name: Vyvanse; Assigned to Arm(s): Medication Arm | Intervention Type: BEHAVIORAL; Name: Behavioral Parent Training; Assigned to Arm(s): Behavioral Parent Training Arm | Intervention Type: DRUG; Name: Methylphenidate; Assigned to Arm(s): Medication Arm
D: Arm Label: Methylphenidate, Dexamphetamine, Placebo; Type: EXPERIMENTAL; Interventions: Drug: Methylphenidate, Drug: Placebo, Drug: Dextroamphetamine | Intervention Type: DRUG; Name: Methylphenidate; Assigned to Arm(s): Methylphenidate, Dexamphetamine, Placebo | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Methylphenidate, Dexamphetamine, Placebo | Intervention Type: DRUG; Name: Dextroamphetamine; Assigned to Arm(s): Methylphenidate, Dexamphetamine, Placebo

Answer: C
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Effectiveness of an Implementation Optimisation Intervention Aimed at Increasing Parent Engagement in HENRY, a Childhood Obesity Prevention Programme: a Cluster Randomised Controlled Trial
Brief Summary: This study will test whether parent engagement (recruitment, attendance) in a Childhood obesity prevention programme (HENRY) can be improved in local authorities randomised to receive an Optimisation intervention (in addition to standard HENRY) compared to those continuing to deliver the programme as standard.


Options:
A: Arm Label: 1M0.5; Type: EXPERIMENTAL; Interventions: Other: Timing of Diet and Flavor Experience | Arm Label: 1M1.5; Type: EXPERIMENTAL; Interventions: Other: Timing of Diet and Flavor Experience | Arm Label: 3M0.5; Type: EXPERIMENTAL; Interventions: Other: Timing of Diet and Flavor Experience | Arm Label: Control; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: OTHER; Name: Timing of Diet and Flavor Experience; Assigned to Arm(s): 1M0.5, 1M1.5, 3M0.5
B: Arm Label: Optimisation + HENRY; Type: EXPERIMENTAL; Interventions: Behavioral: Optimisation + HENRY | Arm Label: HENRY as standard; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: HENRY as standard | Intervention Type: BEHAVIORAL; Name: Optimisation + HENRY; Assigned to Arm(s): Optimisation + HENRY | Intervention Type: BEHAVIORAL; Name: HENRY as standard; Assigned to Arm(s): HENRY as standard
C: Arm Label: intervention; Type: EXPERIMENTAL; Interventions: Behavioral: Intervention | Arm Label: Wait-listed control group; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: Intervention; Assigned to Arm(s): intervention
D: Arm Label: $60 SEBTC Benefit Group; Type: EXPERIMENTAL; Interventions: Other: SEBTC | Arm Label: $30 SEBTC Benefit Group; Type: EXPERIMENTAL; Interventions: Other: SEBTC | Arm Label: No Intervention Group; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: OTHER; Name: SEBTC; Assigned to Arm(s): $30 SEBTC Benefit Group, $60 SEBTC Benefit Group

Answer: B
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Effectiveness of an Implementation Optimisation Intervention Aimed at Increasing Parent Engagement in HENRY, a Childhood Obesity Prevention Programme: a Cluster Randomised Controlled Trial
Brief Summary: This study will test whether parent engagement (recruitment, attendance) in a Childhood obesity prevention programme (HENRY) can be improved in local authorities randomised to receive an Optimisation intervention (in addition to standard HENRY) compared to those continuing to deliver the programme as standard.


Options:
A: Arm Label: Standard HVP Curriculum; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Standard HVP Curriculum | Arm Label: Obesity Prevention; Type: EXPERIMENTAL; Interventions: Behavioral: Standard HVP Curriculum, Behavioral: Obesity Prevention | Intervention Type: BEHAVIORAL; Name: Standard HVP Curriculum; Assigned to Arm(s): Obesity Prevention, Standard HVP Curriculum | Intervention Type: BEHAVIORAL; Name: Obesity Prevention; Assigned to Arm(s): Obesity Prevention
B: Arm Label: Eating and physical activity counseling; Type: EXPERIMENTAL; Interventions: Behavioral: Eating and physical activity counseling | Arm Label: Usual care; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: Eating and physical activity counseling; Assigned to Arm(s): Eating and physical activity counseling
C: Arm Label: Vouchers; Type: ACTIVE_COMPARATOR; Interventions: Other: Vouchers, Other: Nutrition education | Arm Label: Control; Type: OTHER; Interventions: Other: Nutrition education | Intervention Type: OTHER; Name: Vouchers; Assigned to Arm(s): Vouchers | Intervention Type: OTHER; Name: Nutrition education; Assigned to Arm(s): Control, Vouchers
D: Arm Label: Optimisation + HENRY; Type: EXPERIMENTAL; Interventions: Behavioral: Optimisation + HENRY | Arm Label: HENRY as standard; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: HENRY as standard | Intervention Type: BEHAVIORAL; Name: Optimisation + HENRY; Assigned to Arm(s): Optimisation + HENRY | Intervention Type: BEHAVIORAL; Name: HENRY as standard; Assigned to Arm(s): HENRY as standard

Answer: D
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Effectiveness of an Implementation Optimisation Intervention Aimed at Increasing Parent Engagement in HENRY, a Childhood Obesity Prevention Programme: a Cluster Randomised Controlled Trial
Brief Summary: This study will test whether parent engagement (recruitment, attendance) in a Childhood obesity prevention programme (HENRY) can be improved in local authorities randomised to receive an Optimisation intervention (in addition to standard HENRY) compared to those continuing to deliver the programme as standard.


Options:
A: Arm Label: Healthy Children, Strong Families (first); Type: EXPERIMENTAL; Interventions: Behavioral: Healthy Children, Strong Families, Behavioral: Child Safety | Arm Label: Child Safety (first); Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Healthy Children, Strong Families, Behavioral: Child Safety | Intervention Type: BEHAVIORAL; Name: Healthy Children, Strong Families; Assigned to Arm(s): Child Safety (first), Healthy Children, Strong Families (first) | Intervention Type: BEHAVIORAL; Name: Child Safety; Assigned to Arm(s): Child Safety (first), Healthy Children, Strong Families (first)
B: Arm Label: Optimisation + HENRY; Type: EXPERIMENTAL; Interventions: Behavioral: Optimisation + HENRY | Arm Label: HENRY as standard; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: HENRY as standard | Intervention Type: BEHAVIORAL; Name: Optimisation + HENRY; Assigned to Arm(s): Optimisation + HENRY | Intervention Type: BEHAVIORAL; Name: HENRY as standard; Assigned to Arm(s): HENRY as standard
C: Intervention Type: BEHAVIORAL; Name: Nutritional and life style counseling; Assigned to Arm(s): N/A
D: Intervention Type: BEHAVIORAL; Name: attitude change; Assigned to Arm(s): N/A | Intervention Type: BEHAVIORAL; Name: adiposity prevention program; Assigned to Arm(s): N/A

Answer: B
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Effectiveness of an Implementation Optimisation Intervention Aimed at Increasing Parent Engagement in HENRY, a Childhood Obesity Prevention Programme: a Cluster Randomised Controlled Trial
Brief Summary: This study will test whether parent engagement (recruitment, attendance) in a Childhood obesity prevention programme (HENRY) can be improved in local authorities randomised to receive an Optimisation intervention (in addition to standard HENRY) compared to those continuing to deliver the programme as standard.


Options:
A: Arm Label: Intervention group; Type: EXPERIMENTAL; Interventions: Behavioral: Sleep hygiene counseling | Arm Label: Control group; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: Sleep hygiene counseling; Assigned to Arm(s): Intervention group
B: Arm Label: "Fortaleça sua Saúde" program; Type: EXPERIMENTAL; Interventions: Behavioral: "Fortaleça sua Saúde" program | Arm Label: Control; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: "Fortaleça sua Saúde" program; Assigned to Arm(s): "Fortaleça sua Saúde" program
C: Arm Label: Optimisation + HENRY; Type: EXPERIMENTAL; Interventions: Behavioral: Optimisation + HENRY | Arm Label: HENRY as standard; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: HENRY as standard | Intervention Type: BEHAVIORAL; Name: Optimisation + HENRY; Assigned to Arm(s): Optimisation + HENRY | Intervention Type: BEHAVIORAL; Name: HENRY as standard; Assigned to Arm(s): HENRY as standard
D: Arm Label: Low intensity arm; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Dietary, physical activity and sleeping | Arm Label: High intensity arm; Type: EXPERIMENTAL; Interventions: Behavioral: Dietary, physical activity and sleeping | Intervention Type: BEHAVIORAL; Name: Dietary, physical activity and sleeping; Assigned to Arm(s): High intensity arm, Low intensity arm

Answer: C
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Effectiveness of an Implementation Optimisation Intervention Aimed at Increasing Parent Engagement in HENRY, a Childhood Obesity Prevention Programme: a Cluster Randomised Controlled Trial
Brief Summary: This study will test whether parent engagement (recruitment, attendance) in a Childhood obesity prevention programme (HENRY) can be improved in local authorities randomised to receive an Optimisation intervention (in addition to standard HENRY) compared to those continuing to deliver the programme as standard.


Options:
A: Arm Label: Individualized dietetic intervention; Type: OTHER; Interventions: Behavioral: Individualized dietetic intervention-eating habits | Intervention Type: BEHAVIORAL; Name: Individualized dietetic intervention-eating habits; Assigned to Arm(s): Individualized dietetic intervention
B: Arm Label: Eating and physical activity counseling; Type: EXPERIMENTAL; Interventions: Behavioral: Eating and physical activity counseling | Arm Label: Usual care; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: Eating and physical activity counseling; Assigned to Arm(s): Eating and physical activity counseling
C: Arm Label: Optimisation + HENRY; Type: EXPERIMENTAL; Interventions: Behavioral: Optimisation + HENRY | Arm Label: HENRY as standard; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: HENRY as standard | Intervention Type: BEHAVIORAL; Name: Optimisation + HENRY; Assigned to Arm(s): Optimisation + HENRY | Intervention Type: BEHAVIORAL; Name: HENRY as standard; Assigned to Arm(s): HENRY as standard
D: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: Vitamin D | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Drug: Vitamin D | Arm Label: 3; Type: EXPERIMENTAL; Interventions: Drug: Vitamin D | Intervention Type: DRUG; Name: Vitamin D; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Vitamin D; Assigned to Arm(s): 2 | Intervention Type: DRUG; Name: Vitamin D; Assigned to Arm(s): 3

Answer: C
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Prospective Study of Combined ATG Regimen for Prophylaxis of aGVHD in Matched Sibling Donor PBSCT
Brief Summary: The purpose of this study is to determine the efficacy and safety of combined ATG （antithymocyte globulin ） regimen for aGVHD(acute graft-versus-host disease ) prophylaxis in matched sibling donor peripheral blood stem cell transplantation (MSD-PBSCT).


Options:
A: Arm Label: ATG-F; Type: EXPERIMENTAL; Interventions: Drug: ATG-Fresenius S | Arm Label: non-ATG-F; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DRUG; Name: ATG-Fresenius S; Assigned to Arm(s): ATG-F
B: Arm Label: TBI + fludarabine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Conditioning regimen: TBI + Fludarabine | Arm Label: TLI + ATG; Type: ACTIVE_COMPARATOR; Interventions: Drug: Conditioning regimen:TLI (8 Gy) + ATG | Intervention Type: DRUG; Name: Conditioning regimen: TBI + Fludarabine; Assigned to Arm(s): TBI + fludarabine | Intervention Type: DRUG; Name: Conditioning regimen:TLI (8 Gy) + ATG; Assigned to Arm(s): TLI + ATG
C: Arm Label: ATG combined regimen; Type: EXPERIMENTAL; Interventions: Drug: ATG, Drug: CsA, Drug: mycophenolate mofetil, Drug: Methotrexate | Arm Label: no-ATG; Type: ACTIVE_COMPARATOR; Interventions: Drug: CsA, Drug: mycophenolate mofetil, Drug: Methotrexate | Intervention Type: DRUG; Name: ATG; Assigned to Arm(s): ATG combined regimen | Intervention Type: DRUG; Name: CsA; Assigned to Arm(s): ATG combined regimen, no-ATG | Intervention Type: DRUG; Name: mycophenolate mofetil; Assigned to Arm(s): ATG combined regimen, no-ATG | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): ATG combined regimen, no-ATG
D: Arm Label: ATG 7.5mg/kg; Type: EXPERIMENTAL; Interventions: Drug: ATG | Arm Label: ATG 10mg/kg; Type: EXPERIMENTAL; Interventions: Drug: ATG | Intervention Type: DRUG; Name: ATG; Assigned to Arm(s): ATG 10mg/kg, ATG 7.5mg/kg

Answer: C
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Impact of General vs Local Anesthesia on Neurological Function in Patients With Acute Ischemic Stroke Undergoing Endovascular Treatment
Brief Summary: Recent observational studies have found an association between general anaesthesia and increased post-operative mortality in acute ischemic stroke patients undergoing endovascular treatment. It is unknown whether there is a causal relationship in this observation. The investigators are performing a large randomised trial of general versus local anaesthesia to definitively answer the question of whether anaesthetic type alters perioperative outcome.


Options:
A: Arm Label: Sedation; Type: ACTIVE_COMPARATOR; Interventions: Drug: Sedation, Procedure: Intra-arterial Thrombectomy | Arm Label: General Anesthesia; Type: ACTIVE_COMPARATOR; Interventions: Drug: General Anesthesia (GA), Procedure: Intra-arterial Thrombectomy | Intervention Type: DRUG; Name: Sedation; Assigned to Arm(s): Sedation | Intervention Type: DRUG; Name: General Anesthesia (GA); Assigned to Arm(s): General Anesthesia | Intervention Type: PROCEDURE; Name: Intra-arterial Thrombectomy; Assigned to Arm(s): General Anesthesia, Sedation
B: Arm Label: General anaesthesia; Type: ACTIVE_COMPARATOR; Interventions: Procedure: General anaesthesia | Arm Label: Conscious Sedation; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Conscious Sedation | Intervention Type: PROCEDURE; Name: General anaesthesia; Assigned to Arm(s): General anaesthesia | Intervention Type: PROCEDURE; Name: Conscious Sedation; Assigned to Arm(s): Conscious Sedation
C: Arm Label: Local anesthesia; Type: OTHER; Interventions: Other: local anesthesia, Other: Spontaneous breathing | Arm Label: General anesthesia; Type: OTHER; Interventions: Other: Intravenous anesthetics, Other: Controlled ventilation | Intervention Type: OTHER; Name: Intravenous anesthetics; Assigned to Arm(s): General anesthesia | Intervention Type: OTHER; Name: local anesthesia; Assigned to Arm(s): Local anesthesia | Intervention Type: OTHER; Name: Controlled ventilation; Assigned to Arm(s): General anesthesia | Intervention Type: OTHER; Name: Spontaneous breathing; Assigned to Arm(s): Local anesthesia
D: Arm Label: Intubation; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Endovascular recanalisation | Arm Label: No Intubation; Type: EXPERIMENTAL; Interventions: Procedure: Endovascular recanalisation | Intervention Type: PROCEDURE; Name: Endovascular recanalisation; Assigned to Arm(s): Intubation, No Intubation

Answer: C
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Double-blind Randomized Controlled Clinical Trial of 3 Days Versus 5 Days Amoxicillin Dispersible Tablets for Chest-indrawing Childhood Pneumonia Among Children 2-59 Months of Age Presenting to Kamuzu Central Hospital in Lilongwe, Malawi
Brief Summary: This clinical trial evaluates the duration of treatment of chest-indrawing pneumonia in children. Half the children will receive 3 days of amoxicillin dispersible tablets (DT) and then 2 days of placebo, while the other half will receive 5 days of amoxicillin DT.


Options:
A: Arm Label: Treated; Type: N/A; Interventions: N/A | Arm Label: Untreated; Type: N/A; Interventions: N/A
B: Arm Label: Placebo; Type: EXPERIMENTAL; Interventions: Drug: Placebo | Arm Label: 3 Days; Type: ACTIVE_COMPARATOR; Interventions: Drug: Amoxicillin | Intervention Type: DRUG; Name: Amoxicillin; Assigned to Arm(s): 3 Days | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: 3 days amoxicillin + 2 days placebo; Type: EXPERIMENTAL; Interventions: Drug: Amoxicillin, Drug: Placebo | Arm Label: 5 days amoxicillin; Type: ACTIVE_COMPARATOR; Interventions: Drug: Amoxicillin | Intervention Type: DRUG; Name: Amoxicillin; Assigned to Arm(s): 3 days amoxicillin + 2 days placebo, 5 days amoxicillin | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): 3 days amoxicillin + 2 days placebo
D: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Arm Label: Motavizumab; Type: ACTIVE_COMPARATOR; Interventions: Biological: Motavizumab | Intervention Type: BIOLOGICAL; Name: Motavizumab; Assigned to Arm(s): Motavizumab | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo

Answer: C