Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Double-Blind,Placebo-Controlled, Ascending Single-Dose Study of the Safety, Tolerability and Bioeffect of Subcutaneously Administered REGN727 in Healthy Volunteers
Brief Summary: This study will test the safety and tolerability (how the body reacts to the drug) of REGN727 compared with placebo (an inactive substance that contains no medicine) in healthy subjects. The study drug and placebo will be administered by an injection under the skin at one clinic visit. There will be 14 clinic visits, which will include 4 overnight stays. Subjects will be monitored by the study staff for side effects and the body's response to the study drug. Vital signs (blood pressure, temperature, breathing and heart rate) will be checked, and blood and urine samples will be collected at some or all visits.


Options:
A: Arm Label: Group 1 with atorvastatin; Type: EXPERIMENTAL; Interventions: Drug: REGN727(SAR236553) | Arm Label: Group 2 with atorvastatin; Type: EXPERIMENTAL; Interventions: Drug: REGN727(SAR236553) | Arm Label: Group 3 with atorvastatin; Type: EXPERIMENTAL; Interventions: Drug: REGN727(SAR236553) | Arm Label: Group 4 with atorvastatin; Type: EXPERIMENTAL; Interventions: Drug: REGN727(SAR236553) | Arm Label: Group 5 with atorvastatin; Type: EXPERIMENTAL; Interventions: Drug: REGN727(SAR236553) | Arm Label: Group 6 with atorvastatin; Type: EXPERIMENTAL; Interventions: Drug: REGN727(SAR236553) | Arm Label: Group 7 without atorvastatin; Type: EXPERIMENTAL; Interventions: Drug: REGN727(SAR236553) | Arm Label: Group 8 with atorvastatin; Type: EXPERIMENTAL; Interventions: Drug: REGN727(SAR236553) | Intervention Type: DRUG; Name: REGN727(SAR236553); Assigned to Arm(s): Group 1 with atorvastatin, Group 2 with atorvastatin, Group 3 with atorvastatin, Group 4 with atorvastatin, Group 5 with atorvastatin, Group 6 with atorvastatin, Group 7 without atorvastatin, Group 8 with atorvastatin
B: Intervention Type: DRUG; Name: Atorvastatin; Assigned to Arm(s): N/A
C: Arm Label: Cohort 1; Type: EXPERIMENTAL; Interventions: Drug: REGN727, Drug: Placebo | Arm Label: Cohort 2; Type: EXPERIMENTAL; Interventions: Drug: REGN727, Drug: Placebo | Arm Label: Cohort 3; Type: EXPERIMENTAL; Interventions: Drug: REGN727, Drug: Placebo | Arm Label: Cohort 4; Type: EXPERIMENTAL; Interventions: Drug: REGN727, Drug: Placebo | Intervention Type: DRUG; Name: REGN727; Assigned to Arm(s): Cohort 1, Cohort 2, Cohort 3, Cohort 4 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Cohort 1, Cohort 2, Cohort 3, Cohort 4
D: Arm Label: 30 milligram (mg) LY2484595 monotherapy; Type: EXPERIMENTAL; Interventions: Drug: LY2484595, Drug: Placebo for Statins | Arm Label: 100 mg LY2484595 monotherapy; Type: EXPERIMENTAL; Interventions: Drug: LY2484595, Drug: Placebo for Statins | Arm Label: 500 mg LY2484595 monotherapy; Type: EXPERIMENTAL; Interventions: Drug: LY2484595, Drug: Placebo for Statins | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo for LY2484595, Drug: Placebo for Statins | Arm Label: 20 mg Atorvastatin monotherapy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Atorvastatin, Drug: Placebo for LY2484595 | Arm Label: 100 mg LY2484595 + 20 mg Atorvastatin; Type: EXPERIMENTAL; Interventions: Drug: LY2484595, Drug: Atorvastatin | Arm Label: 40 mg Simvastatin monotherapy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Simvastatin, Drug: Placebo for LY2484595 | Arm Label: 100 mg LY2484595 + 40 mg Simvastatin; Type: EXPERIMENTAL; Interventions: Drug: LY2484595, Drug: Simvastatin | Arm Label: 10 mg Rosuvastatin monotherapy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Rosuvastatin, Drug: Placebo for LY2484595 | Arm Label: 100 mg LY2484595 + 10 mg Rosuvastatin; Type: EXPERIMENTAL; Interventions: Drug: LY2484595, Drug: Rosuvastatin | Intervention Type: DRUG; Name: LY2484595; Assigned to Arm(s): 100 mg LY2484595 + 10 mg Rosuvastatin, 100 mg LY2484595 + 20 mg Atorvastatin, 100 mg LY2484595 + 40 mg Simvastatin, 100 mg LY2484595 monotherapy, 30 milligram (mg) LY2484595 monotherapy, 500 mg LY2484595 monotherapy | Intervention Type: DRUG; Name: Atorvastatin; Assigned to Arm(s): 100 mg LY2484595 + 20 mg Atorvastatin, 20 mg Atorvastatin monotherapy | Intervention Type: DRUG; Name: Simvastatin; Assigned to Arm(s): 100 mg LY2484595 + 40 mg Simvastatin, 40 mg Simvastatin monotherapy | Intervention Type: DRUG; Name: Rosuvastatin; Assigned to Arm(s): 10 mg Rosuvastatin monotherapy, 100 mg LY2484595 + 10 mg Rosuvastatin | Intervention Type: DRUG; Name: Placebo for LY2484595; Assigned to Arm(s): 10 mg Rosuvastatin monotherapy, 20 mg Atorvastatin monotherapy, 40 mg Simvastatin monotherapy, Placebo | Intervention Type: DRUG; Name: Placebo for Statins; Assigned to Arm(s): 100 mg LY2484595 monotherapy, 30 milligram (mg) LY2484595 monotherapy, 500 mg LY2484595 monotherapy, Placebo

Answer: C