Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Evaluation of a Novel Long Lasting Insecticidal Net and Indoor Residual Spray Product, Separately and Together, Against Malaria Transmitted by Pyrethroid Resistant Mosquitoes.
Brief Summary: The proposed study is a four-arm randomized control trial (RCT) in 48 villages in the Lakes region in Tanzania comparing the relative effectiveness of 4 vector control interventions for reducing malaria transmission and controlling vector populations in an area where An gambiae s.s is pyrethroid and carbamate resistant: 1/ a standard long lasting insecticidal net (LLIN), 2/ a LLIN which incorporates a piperonyl butoxide (PBO) synergist, 3/ a long lasting indoor residual spray (IRS) formulation used in conjunction with standard pyrethroid LLIN or 4/ the long lasting indoor residual spray (IRS) formulation used in conjunction with the LLIN which incorporates a PBO synergist.

The trial will provide epidemiological, entomological, economic and social evidence of impact, as the investigators shall be measuring the reductions in malaria prevalence and malaria transmission rates EIR, and changes in the frequency of resistance, mosquito species ratios and economic cost effectiveness. The proposed trial will demonstrate whether the novel LLIN and long lasting IRS formulation will be more effective for controlling An.gambiae s.s. and reducing malaria prevalence than current practice with the conventional LLIN. There is great interest in conducting this trial. Alternative vector control products are limited and most new insecticides are not suitable for use on LLINs or as IRS.


Options:
A: Arm Label: Conventional Olyset LLIN; Type: EXPERIMENTAL; Interventions: Other: Conventional Olyset LLIN | Arm Label: Olyset Plus LLIN; Type: EXPERIMENTAL; Interventions: Other: Olyset Plus LLIN | Arm Label: Conventional Olyset LLIN and IRS; Type: EXPERIMENTAL; Interventions: Other: Conventional Olyset LLIN, Other: IRS | Arm Label: Olyset Plus LLIN and IRS; Type: EXPERIMENTAL; Interventions: Other: Olyset Plus LLIN, Other: Conventional Olyset LLIN | Intervention Type: OTHER; Name: Olyset Plus LLIN; Assigned to Arm(s): Olyset Plus LLIN, Olyset Plus LLIN and IRS | Intervention Type: OTHER; Name: Conventional Olyset LLIN; Assigned to Arm(s): Conventional Olyset LLIN, Conventional Olyset LLIN and IRS, Olyset Plus LLIN and IRS | Intervention Type: OTHER; Name: IRS; Assigned to Arm(s): Conventional Olyset LLIN and IRS
B: Arm Label: Universal coverage of Long Lasting Insecticidal Nets (LLIN); Type: ACTIVE_COMPARATOR; Interventions: Device: Long Lasting Insecticidal Nets (LLIN) | Arm Label: LLIN Plus Indoor Residual Spraying; Type: EXPERIMENTAL; Interventions: Other: Indoor residual insecticide spraying (IRS), Device: Long Lasting Insecticidal Nets (LLIN) | Intervention Type: OTHER; Name: Indoor residual insecticide spraying (IRS); Assigned to Arm(s): LLIN Plus Indoor Residual Spraying | Intervention Type: DEVICE; Name: Long Lasting Insecticidal Nets (LLIN); Assigned to Arm(s): LLIN Plus Indoor Residual Spraying, Universal coverage of Long Lasting Insecticidal Nets (LLIN)
C: Arm Label: LLIN plus IRS; Type: EXPERIMENTAL; Interventions: Other: Indoor residual spraying with bendiocarb, Other: LLIN by universal coverage campaign | Arm Label: LLIN only; Type: ACTIVE_COMPARATOR; Interventions: Other: LLIN by universal coverage campaign | Intervention Type: OTHER; Name: Indoor residual spraying with bendiocarb; Assigned to Arm(s): LLIN plus IRS | Intervention Type: OTHER; Name: LLIN by universal coverage campaign; Assigned to Arm(s): LLIN only, LLIN plus IRS
D: Arm Label: IRS; Type: EXPERIMENTAL; Interventions: Other: Actellic CS | Arm Label: non-IRS; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: OTHER; Name: Actellic CS; Assigned to Arm(s): IRS

Answer: A