Please select the eligibility criteria that correspond to the clinical trial below.
Title: CareToy Observational Study: Early Identification of Infants at Risk of Cerebral Palsy
Brief Summary: This observational study aims to early identify, through a rigorous and standardized follow-up, infants at high risk for Cerebral Palsy. After the consent agreement firmed by the parents, infants born at term or preterm with ultrasonographic evidence of brain injury considered at risk for neurodevelopmental disorders will be strictly monitored during the first months of life performing a periodic neurological assessment (Prechtl's General Movement (GMA) and the Hammersmith Infant Neurological Examination) at term age and around 3 months of post term age. Moreover, to study more accurately the brain injury early identified by ultrasonographic brain exam, around 6 weeks of post-term age the enrolled infants will perform, as recommended in infants at risk, brain Magnetic Resonance (RM).

Thanks to the high predictability power of the combination of the clinical observation with the neuroimaging infants at high risk of CP will be early detect. Selected infants, considered at high risk for CP will have the opportunity to perform an home based and family centered early intervention later than 3 post term age.


Options:
A: Inclusion Criteria:

* Infant is born a singleton or twin in the Morgan Stanley Children's Hospital in New York City
* Infant is born 26 and 34 weeks post-conceptional age (PCA)

Exclusion Criteria:

* Mothers cannot understand or speak English
* Mother has history of drug addiction, psychosis or other severe mental illness
* There is not at least one adult other than the mother in the home
* Infant birth weight is below the third percentile for gestational age
* Infant has significant congenital defects
B: Inclusion Criteria:

* neurological signs (Hammersmith Infant Neurological Examination/General Movement Assessment according Precthl's).
* signs of brain injury identified at ultrasound brain exam

Exclusion Criteria:

* brain malformations
* severe sensory deficits
C: Inclusion Criteria:

* gestational age ≥ 28+0 weeks and 32+6 weeks
* corrected age at baseline: between 3 and 9 months;
* achievement of predefined cut off scores in gross motor ability derived from Ages \& Stages Questionnaire® Third Edition (ASQ-3), in relation to corrected age (Bricker and Squires, 1999)

In detail:

* 4 months form (from 3 months to 4 months 30 days) score ≥ 10;
* 6 months form (from 5 months to 6 months 30 days) score ≥ 5 - \< 50;
* 8 months form (from 7 months to 8 months 30 days) ≥ 10 - \<30

Exclusion Criteria:

* infants with gestational age \< 28 weeks or ≥ 33 weeks
* infants small for gestational age (i.e. weight below the 10th, ref)
* presence of brain damage (i.e. brain malformation, intra-ventricular haemorrhage \[IVH\] \>1 ; any degree of periventricular leukomalacia (ref)
* known epilepsy or other form of seizure
* severe sensory deficits (blindness, deafness)
* other severe non neurological malformations
* participation in other experimental studies having rehabilitation aims
D: Inclusion Criteria:

* Preterm infants born in our institution will be included when they complete 48 hours after birth

Exclusion Criteria:

* Congenital malformations

Answer: B