Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Applying Mindfulness-Based Cognitive Therapy to Treatment Resistant Depression
Brief Summary: This study is a randomized, controlled trial of Mindfulness-Based Cognitive Therapy (MBCT) versus Health-Enhancement Program (HEP) for patients with treatment-resistant major depressive disorder (MDD). Both arms of the study will continue to receive the standard medication management treatment as usual (TAU) throughout the study. MBCT is a new technique that has been found to be effective for prevention of relapse in individuals in complete recovery from depression. MBCT is a group-based, 8-week intervention that uses mindfulness meditation as its core therapeutic ingredient. It teaches people to have a different relationship to depressive thoughts and feelings. This study will use an active condition called the Health Enhancement Program (HEP) which was specifically developed to serve as a comparison condition for mindfulness interventions. HEP has been shown to decrease global stress levels and to increase perceived health. Stress has been considered a contributor to depression. One hundred and seventy four patients with MDD who have failed two or more adequate antidepressant trials will be identified and randomly assigned to one of two groups: MBCT+TAU or HEP+TAU. All patients who enroll in the study will undergo follow-up assessments at 3, 6, 9 and 12 months following the intervention. A supplemental portion of the study will enroll 88 patients to undergo functional magnetic resonance imagining (fMRI) scans immediately before and after treatment to better understand the neural pathways implicated in depression and those that may be affected through treatment.


Options:
A: Arm Label: Individual Placement and Support-vocational rehabilitation; Type: EXPERIMENTAL; Interventions: Behavioral: Individual Placement and Support-vocational rehabilitation | Arm Label: Vocational rehabilitation available at study site; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Vocational rehabilitation available | Intervention Type: BEHAVIORAL; Name: Individual Placement and Support-vocational rehabilitation; Assigned to Arm(s): Individual Placement and Support-vocational rehabilitation | Intervention Type: BEHAVIORAL; Name: Vocational rehabilitation available; Assigned to Arm(s): Vocational rehabilitation available at study site
B: Arm Label: Workcoping and IPS; Type: EXPERIMENTAL; Interventions: Behavioral: Workcoping and IPS | Arm Label: Ordinary care by GP or NAV; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Ordinary care by GP or NAV | Intervention Type: BEHAVIORAL; Name: Workcoping and IPS; Assigned to Arm(s): Workcoping and IPS | Intervention Type: BEHAVIORAL; Name: Ordinary care by GP or NAV; Assigned to Arm(s): Ordinary care by GP or NAV
C: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Behavioral: Mindfulness Based Cognitive Therapy | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Health Enhancement Program and medication management | Intervention Type: BEHAVIORAL; Name: Mindfulness Based Cognitive Therapy; Assigned to Arm(s): 1 | Intervention Type: BEHAVIORAL; Name: Health Enhancement Program and medication management; Assigned to Arm(s): 2
D: Arm Label: Control; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: IBBIS MHC; Type: EXPERIMENTAL; Interventions: Behavioral: IBBIS mental health care and standard vocational rehabilitation | Arm Label: IBBIS integrated MCH and VR; Type: EXPERIMENTAL; Interventions: Other: Integrated mental health care and vocational rehabilitation | Intervention Type: BEHAVIORAL; Name: IBBIS mental health care and standard vocational rehabilitation; Assigned to Arm(s): IBBIS MHC | Intervention Type: OTHER; Name: Integrated mental health care and vocational rehabilitation; Assigned to Arm(s): IBBIS integrated MCH and VR

Answer: C