Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Timing of Pessary Care
Brief Summary: This is a prospective trial to investigate optimal timing of care for vaginal pessaries. A vaginal pessary is a silicone device that is placed in the vagina to support the pelvic organs of a woman who has pelvic organ prolapse. Some women are willing and able to remove their own pessary on a regular basis. In women who are either unwilling or unable to remove their own pessary, complete pessary care is provided in the urogynecology office. Complete pessary care involves regular removal and cleaning of the pessary with a vaginal examination. In our practice, the investigators typically remove vaginal pessaries and examine the vagina every 3 months in patients for whom the investigators provide complete pessary care. Interval of pessary removal varies widely between practitioners. In the literature, removal intervals vary from weekly to yearly. In this study, the investigators will randomize participants to pessary care with removal every 12 weeks or every 24 weeks.


Options:
A: Arm Label: Routine; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Extended; Type: EXPERIMENTAL; Interventions: Other: Extended timing of pessary care | Intervention Type: OTHER; Name: Extended timing of pessary care; Assigned to Arm(s): Extended
B: Arm Label: Conjugated Estrogen Group; Type: ACTIVE_COMPARATOR; Interventions: Drug: Promestriene, Drug: Estriol, Drug: Vaginal Moisturizer - Cream | Arm Label: Promestriene Group; Type: ACTIVE_COMPARATOR; Interventions: Drug: Conjugated Estrogen, Drug: Estriol, Drug: Vaginal Moisturizer - Cream | Arm Label: Estriol Group; Type: ACTIVE_COMPARATOR; Interventions: Drug: Conjugated Estrogen, Drug: Promestriene, Drug: Vaginal Moisturizer - Cream | Arm Label: Vaginal Moisturizer Cream; Type: PLACEBO_COMPARATOR; Interventions: Drug: Conjugated Estrogen, Drug: Promestriene, Drug: Estriol | Intervention Type: DRUG; Name: Conjugated Estrogen; Assigned to Arm(s): Estriol Group, Promestriene Group, Vaginal Moisturizer Cream | Intervention Type: DRUG; Name: Promestriene; Assigned to Arm(s): Conjugated Estrogen Group, Estriol Group, Vaginal Moisturizer Cream | Intervention Type: DRUG; Name: Estriol; Assigned to Arm(s): Conjugated Estrogen Group, Promestriene Group, Vaginal Moisturizer Cream | Intervention Type: DRUG; Name: Vaginal Moisturizer - Cream; Assigned to Arm(s): Conjugated Estrogen Group, Estriol Group, Promestriene Group
C: Arm Label: CO2 fractionated vaginal laser; Type: EXPERIMENTAL; Interventions: Device: CO2 fractionated vaginal laser | Arm Label: Estrogens, Conjugated (USP); Type: ACTIVE_COMPARATOR; Interventions: Drug: Estrogens, Conjugated (USP) | Intervention Type: DEVICE; Name: CO2 fractionated vaginal laser; Assigned to Arm(s): CO2 fractionated vaginal laser | Intervention Type: DRUG; Name: Estrogens, Conjugated (USP); Assigned to Arm(s): Estrogens, Conjugated (USP)
D: Arm Label: Treatment group; Type: ACTIVE_COMPARATOR; Interventions: Drug: Premarin vaginal cream | Arm Label: Control group; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo cream | Intervention Type: DRUG; Name: Premarin vaginal cream; Assigned to Arm(s): Treatment group | Intervention Type: DRUG; Name: Placebo cream; Assigned to Arm(s): Control group

Answer: A