Please select the eligibility criteria that correspond to the clinical trial below.
Title: Dexamethasone Twice for Pain Treatment of Total Knee Arthroplasty - A Randomized Blinded Placebo-controlled Clinical Trial
Brief Summary: Dexamethasone twice for pain treatment after total knee arthroplasty - A Placebo-controlled, randomised, parallel 3-group multicentre trial of one and two doses of dexamethasone for postoperative treatment


Options:
A: Inclusion Criteria:

* Women aged 18-81 years old who are scheduled to undergo a major vaginal reconstructive surgery, including hysterectomy with or without hysterectomy

Exclusion Criteria:

* Daily use of steroids or antiemetic agents such as Zofran, Reglan, Compazine and Phenargan within one month of surgery
* Regional anesthesia for surgical procedure
* Chronic pain requiring opioid treatment daily
* History of allergy to the study medication
* Severe renal and liver disease
* Pregnancy
* Non English speaking
* Psychiatric disorder that will preclude completion of questionnaires
* Minor surgery that does not involve overnight admission
* Surgery that does not involve hysterectomy or vaginal intraperitoneal apical suspension
* Hypersensitivity reaction to steroids
* Evidence of systemic fungal infection
* Evidence of any systemic infection
* Uncontrolled diabetes
B: Inclusion Criteria:

* Scheduled for unilateral, primary total knee arthroplasty
* ASA 1-3
* BMI ≥ 18.0 and ≤ 40.0
* Negative urine HCG pregnancy test and use of anti-conception for women in the fertile age
* Patients who gave their written informed consent to participating in the trial after having fully understood the contents of the protocol and restrictions

Exclusion Criteria:

* Patients who cannot cooperate with the trial
* Concomitant participation in another trial involving medication
* Patients who cannot understand or speak Danish
* Patients with allergy to medication used in the trial
* Patients with daily use of high dose opioid (\> oral morphine 30 mg/day or oxycodone 30 mg/day or tramadol 150 mg/day) or any use of other opioids including methadone and transdermal opioids.
* Patients with at daily use of systemic glucocorticoids
* Contraindications against ibuprofen or paracetamol, for example previous ulcer, known heart failure, known liver failure, or known renal failure (eGRF \< 60 ml/kg/1,73m2), known thrombocytopenia (\<100 bil/l); or against treatment with glucocorticoids.
* Dysregulated diabetes (investigators judgement)
* Patients suffering from alcohol and/or drug abuse - based on the investigator's judgement
C: Inclusion Criteria:

* Patients having an abdominal hysterectomy on a benign indication.
* Patients who speak and understand Danish.
* Patients who can give informed consent.

Exclusion Criteria:

* Diabetics
* Regular use of glucocorticoids, opioids or tranquilizers
* Regular treatment with immunosuppressives
* Alcohol or drug abuse
* Morphine intolerance
* Age under 18
* Chronic pain disease eg fibromyalgia, rheumatoid arthritis
* Malign indication for hysterectomy
* BMI over 35
* Decreased kidney function
* ASA III or IV
D: Inclusion Criteria:

* patients ≥ 18 \< 75 years
* ASA physical status I-II
* planned duration of anesthesia ≥ 60 minutes
* Apfel score ≥ 2-3
* elective (laparoscopic) surgery (abdominal, gynecological)
* women: with a highly effective contraception, defined as methods with a pearl index \< 1 (i.e. hormonal contraceptives, IUD)

Exclusion Criteria:

* history of hypersensitivity to any used drugs or additive components used for preparation and stabilization of the named drugs in this trial
* history or reasonable suspicion of malignant hyperthermia and/or degenerative neuromuscular disease, in the subject observed or blood relatives
* history of liver function disorders, leucocytosis and unclear fever after usage of halogenated anesthetics.
* any indisposition that may be aggravated by the use of the drugs investigated:
* liver and/or kidney function disorders
* severe acute or chronic infectious disease (i.e. viral, bacterial, fungal)
* elevated intracranial pressure
* history of gastrointestinal ulcer(s) or inflammatory bowel disease
* severe metabolic disorders
* hematoporphyria
* glaucoma
* hearing disorders
* any disease including air-filled closed cavities, such as pneumothorax, ileus
* pregnancy and lactation period
* subjects under the age of 18 years
* ambulatory surgery
* any disease that is associated with the requirement of a high oxygen yield and/or
* risk of high oxygen consumption:
* severe lung and/or airway disease
* coronary heart disease and/or seriously impaired cardiac function
* severe psychiatric disorder

Answer: B