Please select the eligibility criteria that correspond to the clinical trial below.
Title: Structured Non-operative Treatment of Knee Osteoarthritis - a Randomized Controlled Trial of Pain, Physical Function and Quality of Life With 12months Follow-up
Brief Summary: The purpose of this study is to test whether an algorithm for systematic non-surgical treatment consisting of corrective insoles, neuromuscular training, weight loss, patient education and pharmacological treatment with paracetamol, non steroidal anti inflammatory drugs (NSAIDs) and Pantoprazole provides further improvement in pain, function and quality of life than standard non-surgical treatment (information on the disease and how to treat it) in patients with knee osteoarthritis.

The H1-hypothesis is that the treatment algorithm results in a greater increase in quality of life and functional capacity and greater reduction in pain than standard treatment at the primary endpoint, which is follow-up 12months after the start of the treatment.

See statistical analysis plan available under "Links" for further description of the study.


Options:
A: Key Inclusion criteria:

• Osteoarthritis of the hand

Key Exclusion Criteria:

* Other rheumatic disease, such as rheumatoid arthritis
* Active gastrointestinal ulcer during the last year
* Known allergy to analgesic drugs
B: Inclusion Criteria:

* Knee-OA detected by x-ray (Kellgren \& Lawrence grade 1 or greater)
* KOOS4 of ≤ 75
* Considered not to be a candidate for Total Knee Replacement (TKR) by the orthopedic surgeon.
* The participant is \> 18 years of age.
* The participant can provide relevant and adequate, informed consent.

Exclusion Criteria:

* Prior TKA ipsilateral
* Rheumatoid arthritis
* Mean VAS \> 60mm the last week on a 0-100mm scale
* Possible pregnancy or planning pregnancy;
* Inability to comply with the protocol;
* Inadequacy in written and spoken Danish.
C: Inclusion Criteria:

* Age 40 years or above
* Diagnosis of OA of the knee of at least 6 months duration fulfilling American College of Rheumatology criteria
* Pain in at least one knee of at least moderate severity (Likert scale \[none, mild, moderate, severe, extreme\] or VAS pain score of at least 40 \[0-100\]) on most (at least 15) days of the previous 1 month
* Taking analgesic or nonsteroidal anti-inflammatory agents for control of pain
* Documented radiographic changes of osteoarthritis of the knee (Kellgren-Lawrence grade greater than or equal to 2 at the time of screening)
* Stable on arthritis medications for previous 1 month
* Willingness and ability, with help of a caregiver if necessary, to comply with treatment and follow-up procedures
* Use of effective contraception if woman of childbearing potential
* Signed consent statement

Exclusion Criteria:

* Intra-articular (IA) corticosteroid injection of either knee within a 3 month interval immediately prior to baseline screening
* IA hyaluronates in either knee within the past 6 months
* Tidal lavage or arthroscopy of either knee within the past 12 months
* Medical condition, in the judgment of the examiner and/or study investigators, that may preclude safe participation in protocol or prevents completion of the study, such as: uncontrolled angina and/or congestive heart failure, severe chronic obstructive pulmonary disease, active treatment for cancer, major psychiatric disease, other severe systemic disease, or significant abnormalities on screening physical examination and laboratory tests that reveal clinically important abnormalities of hematological, cardiac, pulmonary, metabolic, renal, hepatic, gastrointestinal or other systems
* Use of any constituent herb in HLXL within the past 3 months
* Current use of Chinese herbs for arthritis
* Use of oral prednisone in the past 30 days
* Current use of anti-coagulants (coumadin, heparin, aspirin \>325 mg per day).
* Use of any investigational drug within the past 30 days
* Inflammatory arthritis (e.g., rheumatoid or psoriatic arthritis)
* Currently participating in another intervention research study
* Unwilling to be randomized
* Plan to move residence away from the immediate area within the next 2 months
* Drug or alcohol abuse sufficient to hinder compliance with treatment or follow-up procedures
* Pregnant or lactating
* Exclusive use of a wheel chair
* Surgery in either knee in past one year
D: Inclusion Criteria:

* Diagnosis of knee osteoarthritis according to the clinical and radiological criteria of the American College of Rheumatology (ACR), with minimum symptom severity/characteristics

Exclusion Criteria:

* Standard exclusions apply

Answer: B