Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Effect of an Electronic Nicotine Delivery Device (ENDD) on Smoking Cessation and Reduction: a Pilot Study
Brief Summary: The study's major aim is to investigate the ability of a commercial Electronic Nicotine Delivery Device (ENDD) to induce long-term smoking reduction/abstinence in smokers unwilling to quit. Secondary aims are to monitor adverse events and measure participants' perception and acceptance of the product.

This pilot study will evaluate smoking reduction/abstinence effects, product preferences, and adverse events of a currently marketed device in Italy ("Categoria" electronic cigarette - "ORIGINAL" 7.2 mg nicotine cartridges). The primary hypothesis is that the E-Cigarette is a safe device that allows smoking reduction or abstinence in smokers.


Options:
A: Arm Label: E-Cigarette 7.2 mg nicotine; Type: EXPERIMENTAL; Interventions: Device: E-Cigarette 7.2 mg nicotine | Intervention Type: DEVICE; Name: E-Cigarette 7.2 mg nicotine; Assigned to Arm(s): E-Cigarette 7.2 mg nicotine
B: Arm Label: Arm I (different type of ENDS product at each visit); Type: EXPERIMENTAL; Interventions: Other: Electronic Cigarette, Other: Laboratory Biomarker Analysis, Other: Pharmacological Study, Other: Questionnaire Administration | Arm Label: Arm II (BLU e-cigarette ENDS product with different flavors); Type: EXPERIMENTAL; Interventions: Other: Electronic Cigarette, Other: Laboratory Biomarker Analysis, Other: Pharmacological Study, Other: Questionnaire Administration | Intervention Type: OTHER; Name: Electronic Cigarette; Assigned to Arm(s): Arm I (different type of ENDS product at each visit) | Intervention Type: OTHER; Name: Electronic Cigarette; Assigned to Arm(s): Arm II (BLU e-cigarette ENDS product with different flavors) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Arm I (different type of ENDS product at each visit), Arm II (BLU e-cigarette ENDS product with different flavors) | Intervention Type: OTHER; Name: Pharmacological Study; Assigned to Arm(s): Arm I (different type of ENDS product at each visit), Arm II (BLU e-cigarette ENDS product with different flavors) | Intervention Type: OTHER; Name: Questionnaire Administration; Assigned to Arm(s): Arm I (different type of ENDS product at each visit), Arm II (BLU e-cigarette ENDS product with different flavors)
C: Arm Label: HIGH NICOTINE; Type: N/A; Interventions: N/A
D: Arm Label: Patch; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine patch, Behavioral: Behavioural support | Arm Label: Patch and nicotine-free e-cigarette; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine patch, Device: e-cigarette, Behavioral: Behavioural support | Arm Label: Patch and nicotine e-cigarette; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine patch, Device: e-cigarette, Drug: Nicotine, Behavioral: Behavioural support | Intervention Type: DRUG; Name: Nicotine patch; Assigned to Arm(s): Patch, Patch and nicotine e-cigarette, Patch and nicotine-free e-cigarette | Intervention Type: DEVICE; Name: e-cigarette; Assigned to Arm(s): Patch and nicotine e-cigarette, Patch and nicotine-free e-cigarette | Intervention Type: DRUG; Name: Nicotine; Assigned to Arm(s): Patch and nicotine e-cigarette | Intervention Type: BEHAVIORAL; Name: Behavioural support; Assigned to Arm(s): Patch, Patch and nicotine e-cigarette, Patch and nicotine-free e-cigarette

Answer: A