Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Double Blind, Placebo Controlled Study to Investigate the Effect of Donepezil and Gabapentin Combination on an Experimental Pain Model in Healthy Subjects
Brief Summary: This study will compare the effects of gabapentin alone, and gabapentin + donepezil given together in two types of experimental electrical pain tests in up to 48 healthy male subjects (after 24 recruited in the first cohort an interim analysis will be performed).

The study is a randomized, double blind, placebo controlled, 3 was cross-over design study with incomplete block design and 4 treatment options. Placebo, gabapentin alone (lower dose and higher dose) or gabapentin (lower dose) with donepezil.


Options:
A: Arm Label: Pregabalin; Type: ACTIVE_COMPARATOR; Interventions: Drug: pregabalin | Arm Label: Duloxetine; Type: EXPERIMENTAL; Interventions: Drug: duloxetine hydrochloride | Arm Label: Gabapentin + Duloxetine; Type: EXPERIMENTAL; Interventions: Drug: duloxetine hydrochloride, Drug: gabapentin | Intervention Type: DRUG; Name: duloxetine hydrochloride; Assigned to Arm(s): Duloxetine, Gabapentin + Duloxetine | Intervention Type: DRUG; Name: pregabalin; Assigned to Arm(s): Pregabalin | Intervention Type: DRUG; Name: gabapentin; Assigned to Arm(s): Gabapentin + Duloxetine
B: Arm Label: Gabapentin lower dose alone; Type: EXPERIMENTAL; Interventions: Drug: Gabapentin lower dose | Arm Label: Gabapentin higher dose alone; Type: ACTIVE_COMPARATOR; Interventions: Other: Placebo (Dop) | Arm Label: Gabapentin in combination with donepezil; Type: EXPERIMENTAL; Interventions: Drug: Donepezil, Drug: Gabapentin higher dose | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo (Gaba) | Intervention Type: DRUG; Name: Gabapentin lower dose; Assigned to Arm(s): Gabapentin lower dose alone | Intervention Type: DRUG; Name: Donepezil; Assigned to Arm(s): Gabapentin in combination with donepezil | Intervention Type: OTHER; Name: Placebo (Dop); Assigned to Arm(s): Gabapentin higher dose alone | Intervention Type: OTHER; Name: Placebo (Gaba); Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: Gabapentin higher dose; Assigned to Arm(s): Gabapentin in combination with donepezil
C: Arm Label: Epidural steroids; Type: EXPERIMENTAL; Interventions: Procedure: epidural steroid injection, Drug: Placebo gabapentin | Arm Label: Gabapentin; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Sham epidural steroid injection, Drug: Gabapentin | Intervention Type: PROCEDURE; Name: epidural steroid injection; Assigned to Arm(s): Epidural steroids | Intervention Type: PROCEDURE; Name: Sham epidural steroid injection; Assigned to Arm(s): Gabapentin | Intervention Type: DRUG; Name: Gabapentin; Assigned to Arm(s): Gabapentin | Intervention Type: DRUG; Name: Placebo gabapentin; Assigned to Arm(s): Epidural steroids
D: Arm Label: G-ER; Type: EXPERIMENTAL; Interventions: Drug: Gabapentin Extended Release tablets | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Gabapentin Extended Release tablets; Assigned to Arm(s): G-ER | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo

Answer: B