Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Golimumab in the Treatment of Chinese Subjects With Ankylosing Spondylitis
Brief Summary: The purpose of this study is to evaluate the safety and efficacy of golimumab in Chinese patients with ankylosing spondylitis


Options:
A: Inclusion Criteria:

* Adult patients (\> 18 years old)
* With a diagnosis of AS
* With at least one of the following evidences for active inflammation, present within 3 months before inclusion: a serum C-reactive protein (CRP) level above twice the upper limit value of the normal range, a positive magnetic resonance imaging of the spine or sacro-iliac joints, a vascularized enthesitis by power-Doppler ultrasound technic.
* Presence of clinically active axial disease, as defined by 1) a Bath AS Disease Activity Index (BASDAI) (18) of ≥ 3/10, and 2) a score of ≥ 3/10 for axial pain (second item of BASDAI).
* Disease-modifying antirheumatic drugs (DMARDs), such as sulphasalazine, methotrexate, hydroxychloroquine, intra-muscular gold, thiol compound, cyclosporin, intravenous biphosphonate had to be discontinued for at least 4 weeks before inclusion.
* Dosages of NSAIDs and corticosteroid were required to remain stable for at least 4 weeks before inclusion.
* A negative pregnancy test result was required for non menopausal female patients, and contraception during the study period and for six months after the last infusion of infliximab was recommended to all patients of childbearing potential.

Exclusion Criteria:

* Pregnancy.
* Breastfeeding.
* Vaccination with a live organism during the last month.
* Present infection or any episode of serious infection within the last three months.
* Active malignancy within the previous five years.
* Alcohol or drug addiction.
* Severe chronic concomitant disease.
* Administration of an investigational drug within the last three months, or of any known TNF inhibitor therapy in the past (such as thalidomide, infliximab or etanercept).
B: Inclusion Criteria:

- Have a diagnosis of definite akylosing spondylitis for at least 3 months

* Have symptoms of active disease at screening and at baseline
* no active infections

Exclusion Criteria:

* Have other inflammatory diseases that might confound the evaluations of benefit from the golimumab therapy
* Have complete ankylosis of the spine
* Have a history of latent or active granulomatous infection
* Have had a serious infection, or have been hospitalized for an infection, or have been treated with intravenous (IV) antibiotics for an infection within 2 months prior to first administration of study agent.
C: Inclusion criteria

* Active and severe ankylosing spondylitis
* Ankylosing spondylitis refractory to standard anti-rheumatic treatment
* Between 18 and 70 years of age

Exclusion criteria

* Prior exposure to any TNF-inhibitor, including etanercept
* DMARDs (other than hydroxychloroquine, methotrexate and sulphasalazine) within 4 weeks of study drug initiation
* Dose of NSAIDs changed within two weeks of study drug initiation
D: Inclusion Criteria:

* Clinical diagnosis of ankylosing spondylitis
* Active ankylosing spondylitis

Exclusion Criteria:

* Complete ankylosis of spine
* Previous treatment with etanercept

Answer: B