Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Phase II Trial of Topotecan, Cisplatin and Bevacizumab for Recurrent/Persistent Cervical Cancer
Brief Summary: The purpose of this study is to determine whether the combination of topotecan, cisplatin and bevacizumab is effective in the treatment of recurrent or persistent cervical cancer


Options:
A: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Drug: chemotherapy: Paclitaxel/Cisplatin | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Drug: chemotherapy: Paclitaxel/Carboplatin | Intervention Type: DRUG; Name: chemotherapy: Paclitaxel/Cisplatin; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: chemotherapy: Paclitaxel/Carboplatin; Assigned to Arm(s): 2
B: Arm Label: Arm I (paclitaxel and cisplatin); Type: ACTIVE_COMPARATOR; Interventions: Drug: Cisplatin, Other: Laboratory Biomarker Analysis, Drug: Paclitaxel, Other: Quality-of-Life Assessment, Other: Questionnaire Administration | Arm Label: Arm II (paclitaxel, cisplatin, bevacizumab); Type: EXPERIMENTAL; Interventions: Biological: Bevacizumab, Drug: Cisplatin, Other: Laboratory Biomarker Analysis, Drug: Paclitaxel, Other: Quality-of-Life Assessment, Other: Questionnaire Administration | Arm Label: Arm III (topotecan hydrochloride and paclitaxel); Type: EXPERIMENTAL; Interventions: Other: Laboratory Biomarker Analysis, Drug: Paclitaxel, Other: Quality-of-Life Assessment, Other: Questionnaire Administration, Drug: Topotecan Hydrochloride | Arm Label: Arm IV (topotecan hydrochloride, paclitaxel, bevacizumab); Type: EXPERIMENTAL; Interventions: Biological: Bevacizumab, Other: Laboratory Biomarker Analysis, Drug: Paclitaxel, Other: Quality-of-Life Assessment, Other: Questionnaire Administration, Drug: Topotecan Hydrochloride | Intervention Type: BIOLOGICAL; Name: Bevacizumab; Assigned to Arm(s): Arm II (paclitaxel, cisplatin, bevacizumab), Arm IV (topotecan hydrochloride, paclitaxel, bevacizumab) | Intervention Type: DRUG; Name: Cisplatin; Assigned to Arm(s): Arm I (paclitaxel and cisplatin), Arm II (paclitaxel, cisplatin, bevacizumab) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Arm I (paclitaxel and cisplatin), Arm II (paclitaxel, cisplatin, bevacizumab), Arm III (topotecan hydrochloride and paclitaxel), Arm IV (topotecan hydrochloride, paclitaxel, bevacizumab) | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): Arm I (paclitaxel and cisplatin), Arm II (paclitaxel, cisplatin, bevacizumab), Arm III (topotecan hydrochloride and paclitaxel), Arm IV (topotecan hydrochloride, paclitaxel, bevacizumab) | Intervention Type: OTHER; Name: Quality-of-Life Assessment; Assigned to Arm(s): Arm I (paclitaxel and cisplatin), Arm II (paclitaxel, cisplatin, bevacizumab), Arm III (topotecan hydrochloride and paclitaxel), Arm IV (topotecan hydrochloride, paclitaxel, bevacizumab) | Intervention Type: OTHER; Name: Questionnaire Administration; Assigned to Arm(s): Arm I (paclitaxel and cisplatin), Arm II (paclitaxel, cisplatin, bevacizumab), Arm III (topotecan hydrochloride and paclitaxel), Arm IV (topotecan hydrochloride, paclitaxel, bevacizumab) | Intervention Type: DRUG; Name: Topotecan Hydrochloride; Assigned to Arm(s): Arm III (topotecan hydrochloride and paclitaxel), Arm IV (topotecan hydrochloride, paclitaxel, bevacizumab)
C: Arm Label: Arm A; Type: ACTIVE_COMPARATOR; Interventions: Drug: Bevacizumab, Drug: Cisplatin/Carboplatin, Drug: Paclitaxel | Arm Label: Arm B; Type: EXPERIMENTAL; Interventions: Drug: Atezolizumab, Drug: Bevacizumab, Drug: Cisplatin/Carboplatin, Drug: Paclitaxel | Intervention Type: DRUG; Name: Atezolizumab; Assigned to Arm(s): Arm B | Intervention Type: DRUG; Name: Bevacizumab; Assigned to Arm(s): Arm A, Arm B | Intervention Type: DRUG; Name: Cisplatin/Carboplatin; Assigned to Arm(s): Arm A, Arm B | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): Arm A, Arm B
D: Arm Label: I; Type: EXPERIMENTAL; Interventions: Drug: Topotecan, Drug: Cisplatin, Drug: Bevacizumab | Intervention Type: DRUG; Name: Topotecan; Assigned to Arm(s): I | Intervention Type: DRUG; Name: Cisplatin; Assigned to Arm(s): I | Intervention Type: DRUG; Name: Bevacizumab; Assigned to Arm(s): I

Answer: D