Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomised Controlled Trial Investigating the Efficacy and Safety of an Electronic Nicotine Delivery Device (E-Cigarette) in Smokers
Brief Summary: The study's major aim is to investigate the ability of a commercial Electronic Nicotine Delivery Device (E-Cigarette) to induce long-term smoking reduction/abstinence in smokers unwilling to quit. Secondary aims are to investigate changes in withdrawal symptoms and cravings and to examine whether concomitant use of the E-Cigarette and smoking is safe.

The study will monitor smoking reduction/abstinence effects, changes in withdrawal symptoms, and adverse events of a currently marketed device in Italy ("Categoria" electronic cigarette - "ORIGINAL" 7.2 mg nicotine cartridges).

The primary hypothesis is that the E-Cigarette is a safe device that allows smoking reduction or abstinence in smokers possibly by suppressing withdrawal symptoms and cravings.


Options:
A: Arm Label: EGO/CE4, 9mg nicotine; Type: OTHER; Interventions: Device: EGO/CE4, 9mg nicotine | Intervention Type: DEVICE; Name: EGO/CE4, 9mg nicotine; Assigned to Arm(s): EGO/CE4, 9mg nicotine
B: Arm Label: ABDC; Type: EXPERIMENTAL; Interventions: Other: Myblu variant A, Other: Myblu variant B, Other: Myblu variant C, Other: Myblu variant D | Arm Label: BCAD; Type: EXPERIMENTAL; Interventions: Other: Myblu variant A, Other: Myblu variant B, Other: Myblu variant C, Other: Myblu variant D | Arm Label: CDBA; Type: EXPERIMENTAL; Interventions: Other: Myblu variant A, Other: Myblu variant B, Other: Myblu variant C, Other: Myblu variant D | Arm Label: DACB; Type: EXPERIMENTAL; Interventions: Other: Myblu variant A, Other: Myblu variant B, Other: Myblu variant C, Other: Myblu variant D | Arm Label: EFHG; Type: EXPERIMENTAL; Interventions: Other: Myblu variant E, Other: Myblu variant F, Other: Myblu variant G, Other: Myblu variant H | Arm Label: FGEH; Type: EXPERIMENTAL; Interventions: Other: Myblu variant E, Other: Myblu variant F, Other: Myblu variant G, Other: Myblu variant H | Arm Label: GHFE; Type: EXPERIMENTAL; Interventions: Other: Myblu variant E, Other: Myblu variant F, Other: Myblu variant G, Other: Myblu variant H | Arm Label: HEGF; Type: EXPERIMENTAL; Interventions: Other: Myblu variant E, Other: Myblu variant F, Other: Myblu variant G, Other: Myblu variant H | Intervention Type: OTHER; Name: Myblu variant A; Assigned to Arm(s): ABDC, BCAD, CDBA, DACB | Intervention Type: OTHER; Name: Myblu variant B; Assigned to Arm(s): ABDC, BCAD, CDBA, DACB | Intervention Type: OTHER; Name: Myblu variant C; Assigned to Arm(s): ABDC, BCAD, CDBA, DACB | Intervention Type: OTHER; Name: Myblu variant D; Assigned to Arm(s): ABDC, BCAD, CDBA, DACB | Intervention Type: OTHER; Name: Myblu variant E; Assigned to Arm(s): EFHG, FGEH, GHFE, HEGF | Intervention Type: OTHER; Name: Myblu variant F; Assigned to Arm(s): EFHG, FGEH, GHFE, HEGF | Intervention Type: OTHER; Name: Myblu variant G; Assigned to Arm(s): EFHG, FGEH, GHFE, HEGF | Intervention Type: OTHER; Name: Myblu variant H; Assigned to Arm(s): EFHG, FGEH, GHFE, HEGF
C: Arm Label: Product use sequence ABDC; Type: EXPERIMENTAL; Interventions: Other: Myblu flavor A_2.4, Other: Myblu flavor B_2.4, Other: Myblu flavor C_2.4, Other: Myblu flavor D_2.4 | Arm Label: Product use sequence BCAD; Type: EXPERIMENTAL; Interventions: Other: Myblu flavor A_2.4, Other: Myblu flavor B_2.4, Other: Myblu flavor C_2.4, Other: Myblu flavor D_2.4 | Arm Label: Product use sequence CDBA; Type: EXPERIMENTAL; Interventions: Other: Myblu flavor A_2.4, Other: Myblu flavor C_2.4, Other: Myblu flavor D_2.4 | Arm Label: Product use sequence DACB; Type: EXPERIMENTAL; Interventions: Other: Myblu flavor A_2.4, Other: Myblu flavor B_2.4, Other: Myblu flavor C_2.4, Other: Myblu flavor D_2.4 | Arm Label: Product use sequence EFHG; Type: EXPERIMENTAL; Interventions: Other: Myblu flavor E_1.2, Other: Myblu flavor F_1.2, Other: Myblu flavor G_2.4, Other: Myblu flavor H_2.4 | Arm Label: Product use sequence FGEH; Type: EXPERIMENTAL; Interventions: Other: Myblu flavor E_1.2, Other: Myblu flavor F_1.2, Other: Myblu flavor G_2.4, Other: Myblu flavor H_2.4 | Arm Label: Product use sequence GHFE; Type: EXPERIMENTAL; Interventions: Other: Myblu flavor E_1.2, Other: Myblu flavor F_1.2, Other: Myblu flavor G_2.4, Other: Myblu flavor H_2.4 | Arm Label: Product use sequence HEGF; Type: EXPERIMENTAL; Interventions: Other: Myblu flavor E_1.2, Other: Myblu flavor F_1.2, Other: Myblu flavor G_2.4, Other: Myblu flavor H_2.4 | Intervention Type: OTHER; Name: Myblu flavor A_2.4; Assigned to Arm(s): Product use sequence ABDC, Product use sequence BCAD, Product use sequence CDBA, Product use sequence DACB | Intervention Type: OTHER; Name: Myblu flavor B_2.4; Assigned to Arm(s): Product use sequence ABDC, Product use sequence BCAD, Product use sequence DACB | Intervention Type: OTHER; Name: Myblu flavor C_2.4; Assigned to Arm(s): Product use sequence ABDC, Product use sequence BCAD, Product use sequence CDBA, Product use sequence DACB | Intervention Type: OTHER; Name: Myblu flavor D_2.4; Assigned to Arm(s): Product use sequence ABDC, Product use sequence BCAD, Product use sequence CDBA, Product use sequence DACB | Intervention Type: OTHER; Name: Myblu flavor E_1.2; Assigned to Arm(s): Product use sequence EFHG, Product use sequence FGEH, Product use sequence GHFE, Product use sequence HEGF | Intervention Type: OTHER; Name: Myblu flavor F_1.2; Assigned to Arm(s): Product use sequence EFHG, Product use sequence FGEH, Product use sequence GHFE, Product use sequence HEGF | Intervention Type: OTHER; Name: Myblu flavor G_2.4; Assigned to Arm(s): Product use sequence EFHG, Product use sequence FGEH, Product use sequence GHFE, Product use sequence HEGF | Intervention Type: OTHER; Name: Myblu flavor H_2.4; Assigned to Arm(s): Product use sequence EFHG, Product use sequence FGEH, Product use sequence GHFE, Product use sequence HEGF
D: Arm Label: HIGH NICOTINE; Type: N/A; Interventions: N/A

Answer: D