Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Quantification of Dialysis Performance of Different Dialyzer Membranes With Different Coagulation Strategies, Using a Reference microCT Scanning Technique
Brief Summary: Coagulation within the dialyzer membrane fibres is an obvious biological sign of bio-incompatibility. To avoid clotting during extracorporeal treatment, an anticoagulant is added to the circuit, resulting in an increased risk for bleeding complications.

In addition, there is evidence that a substantial number of fibers can become blocked before this is reflected in routinely observed parameters, or in termination of the dialysis session. Little is known about the impact of such subclinical clotting on dialyzer performance in terms of solute clearance.

Membrane clogging due to deposition of proteins and red blood cells on the dialysis membrane may influence both the diffusive and convective transport characteristics of the dialyzer membrane before leading to complete dialyzer clotting.

In 2018, the invesitgators described a method to objectively count the number of blocked fibres inside a dialyzer using a micro-CT scanning technique.

In the present trial, the investigators use this method to assess the resistance of the dialyzer to clotting, and to evaluate the impact of subclinical fibre blocking on solute removal and thus performance of a dialyzer during a dialysis session.

The aim of this randomized cross-over study is to objectively quantify the performance of different dialyzer membranes: ATA™ membrane in the Solacea™ dialyzer, polysulfone membrane in the FX800 dialyzer, and the heparin-coated AN membrane in the Evodial dialyzer, and this with different anticoagulation strategies.


Options:
A: Arm Label: heparin anticoagulation; Type: ACTIVE_COMPARATOR; Interventions: Drug: Heparin | Arm Label: citrate anticoagulation; Type: EXPERIMENTAL; Interventions: Drug: Citrate | Intervention Type: DRUG; Name: Heparin; Assigned to Arm(s): heparin anticoagulation | Intervention Type: DRUG; Name: Citrate; Assigned to Arm(s): citrate anticoagulation
B: Arm Label: Citrate dialysate; Type: ACTIVE_COMPARATOR; Interventions: Other: Citrate dialysate | Arm Label: Acetate dialysate; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: OTHER; Name: Citrate dialysate; Assigned to Arm(s): Citrate dialysate
C: Arm Label: Solacea_postHDF_1/1anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_postHDF_1/2anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: FX800_postHDF_1/1anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: FX800_postHDF_1/2anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_HD_1/1anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_HD_1/2anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: FX800_HD_1/1anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: FX800_HD_1/2anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy, Other: preparation of dialyzer | Arm Label: FX800_HD_1/2anticoagulation_albuprime; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy, Other: preparation of dialyzer | Arm Label: Evodial_HD_no anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Evodial_HD_no anticoagulation_albuprime; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy, Other: preparation of dialyzer | Arm Label: Solacea_preHDF_1/4anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_postHDF_1/4anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_HD_1/4anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_preHDF_no anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_postHDF_no anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Arm Label: Solacea_HD_no anticoagulation; Type: EXPERIMENTAL; Interventions: Device: choice of dialyzer, Other: choice of dialysis mode, Other: choice of anticoagulation strategy | Intervention Type: DEVICE; Name: choice of dialyzer; Assigned to Arm(s): Evodial_HD_no anticoagulation, Evodial_HD_no anticoagulation_albuprime, FX800_HD_1/1anticoagulation, FX800_HD_1/2anticoagulation, FX800_HD_1/2anticoagulation_albuprime, FX800_postHDF_1/1anticoagulation, FX800_postHDF_1/2anticoagulation, Solacea_HD_1/1anticoagulation, Solacea_HD_1/2anticoagulation, Solacea_HD_1/4anticoagulation, Solacea_HD_no anticoagulation, Solacea_postHDF_1/1anticoagulation, Solacea_postHDF_1/2anticoagulation, Solacea_postHDF_1/4anticoagulation, Solacea_postHDF_no anticoagulation, Solacea_preHDF_1/4anticoagulation, Solacea_preHDF_no anticoagulation | Intervention Type: OTHER; Name: choice of dialysis mode; Assigned to Arm(s): Evodial_HD_no anticoagulation, Evodial_HD_no anticoagulation_albuprime, FX800_HD_1/1anticoagulation, FX800_HD_1/2anticoagulation, FX800_HD_1/2anticoagulation_albuprime, FX800_postHDF_1/1anticoagulation, FX800_postHDF_1/2anticoagulation, Solacea_HD_1/1anticoagulation, Solacea_HD_1/2anticoagulation, Solacea_HD_1/4anticoagulation, Solacea_HD_no anticoagulation, Solacea_postHDF_1/1anticoagulation, Solacea_postHDF_1/2anticoagulation, Solacea_postHDF_1/4anticoagulation, Solacea_postHDF_no anticoagulation, Solacea_preHDF_1/4anticoagulation, Solacea_preHDF_no anticoagulation | Intervention Type: OTHER; Name: choice of anticoagulation strategy; Assigned to Arm(s): Evodial_HD_no anticoagulation, Evodial_HD_no anticoagulation_albuprime, FX800_HD_1/1anticoagulation, FX800_HD_1/2anticoagulation, FX800_HD_1/2anticoagulation_albuprime, FX800_postHDF_1/1anticoagulation, FX800_postHDF_1/2anticoagulation, Solacea_HD_1/1anticoagulation, Solacea_HD_1/2anticoagulation, Solacea_HD_1/4anticoagulation, Solacea_HD_no anticoagulation, Solacea_postHDF_1/1anticoagulation, Solacea_postHDF_1/2anticoagulation, Solacea_postHDF_1/4anticoagulation, Solacea_postHDF_no anticoagulation, Solacea_preHDF_1/4anticoagulation, Solacea_preHDF_no anticoagulation | Intervention Type: OTHER; Name: preparation of dialyzer; Assigned to Arm(s): Evodial_HD_no anticoagulation_albuprime, FX800_HD_1/2anticoagulation, FX800_HD_1/2anticoagulation_albuprime
D: Arm Label: nafamostat; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nafamostat Mesylate | Arm Label: Cnoxane; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DRUG; Name: Nafamostat Mesylate; Assigned to Arm(s): nafamostat

Answer: C