Please select the eligibility criteria that correspond to the clinical trial below.
Title: Effect of Plant Stanol Ester-Containing Spread Based on Extra Virgin Olive Oil on Estimated Cardiovascular Risk, and Lipid-Inflammatory-Haemostatic Factors in Comparison to Mediterranean Diet: A Randomized, Placebo-Controlled Trial.
Brief Summary: Since it is very difficult to have the real thing (Mediterranean diet) we need to find an alternative to reduce cardiovascular disease (CVD) risk in subjects with moderate hypercholesterolaemia (a major CVD risk factor) living in western countries. Therefore, this proposed study is designed to assess if giving olive oil supplements, with or without stanol ester, is equivalent to following a Mediterranean diet. Furthermore, the stanol-olive oil combination may prove to be superior to olive oil alone.


Options:
A: Inclusion Criteria:

* Age 30-65 years old
* BMI 27-38 kg/m2
* + two other IDF criteria for metabolic syndrome
* Anti-hypertensives and lipid-lowering medication are allowed

Exclusion Criteria:

* Fasting plasma glucose \> 7.0 mmol/l
* Fasting plasma triglycerides \> 3.0 mmol/l
* Fasting plasma total cholesterol \> 6.5 mmol/l
* Blood pressure \> 160/100 mmHg
* Preceding weight change of 5% or more or active weight loss during preceding 6 months
* Any disease or condition that may hamper the successful participation of the intervention: liver disease, kidney disease, diabetes (both type 1 and type 2), thyroid disease (Newly found unstabilized disease), Myocardial infarction within previous 6 months
* Alcohol abuse (\> 40 g/day)
* Oral corticosteroid therapy
* Severe psychiatric disorders
* Cancer under treatment
* Coeliac disease
* Exceptional diets (Atkin's, vegan, allergies to fish or cereals, other extensive allergies)
* Binge eating
* Unwillingness to discontinue the use of fish and vegetable oil or stanol and sterol ester supplements or products
B: Inclusion Criteria:

* Male and female subjects over 45 years of age with mild hypercholesterolaemia (TC levels: 200 mg/dl - 230 mg/dl)

Exclusion Criteria:

Subjects with

* Established CVD (coronary heart disease, peripheral arterial disease, aortic aneurysm, or symptomatic carotid artery disease) or T2DM
* Chronic diseases (including liver diseases)
* Pregnancy
* Malignancies
* Unwillingness to participate
C: Inclusion Criteria:

* Any evidence of coronary artery disease (CAD) over the preceding 10 years, as defined by any of the following criteria:

  * defined by previous myocardial infarction,
  * stable or unstable angina,
  * history of atherosclerotic stenosis ≥70% of the diameter of any coronary artery on conventional or computed tomographic (CT) coronary angiography,
  * history of angioplasty, stenting, or coronary artery bypass surgery)
* Any evidence of stroke in the preceding 10 years
* Peripheral Arterial Disease over the preceding 10 years, as defined by any of the following criteria:

  * ankle/arm ratio \<0.9 of systolic blood pressure in either leg at rest, angiography or Doppler demonstrating \>70% stenosis in a cardiac artery,
  * intermittent claudication,
  * vascular surgery for atherosclerotic disease,
  * amputation due to atherosclerotic disease,
  * aortic aneurysm

Exclusion Criteria:

* Refusal to provide Informed Consent Statement
* neurocognitive or psychiatric condition that may hinder collection of reliable clinical data (defined at the trial investigator's discretion)
* Life expectancy less than 6 months
* Pregnancy or lactation
* Liver failure with a history of encephalopathy or anasarca
* Renal Failure with indication for dialysis
* Congestive heart failure
* Previous organ transplantation
* Wheelchair use
* Any restrictions to receiving an oral diet.
D: Inclusion Criteria:

* those permanently assigned to one of the 45 IFD stations
* with a fire department-provided medical exam in the last two years
* at least 18 years of age
* full duty status at the time of consent

Exclusion Criteria:

* those without a recorded fire department exam in the last two years
* less than 18 years of age
* restrictions on duty at the time of consent.

Answer: B