Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Double-blind, Randomised, Placebo and Active Controlled, Parallel Group Study to Evaluate the Analgesic Effect of a Single Oral Administration of Four Different Combination Doses of DKP.TRIS With TRAM.HCL in Comparison With the Single Agents, on Moderate to Severe Pain Following Impacted Third Mandibular Molar Tooth Extraction
Brief Summary: The purpose of this study is to evaluate the analgesic efficacy of Dexketoprofen Trometamol and Tramadol Hydrochloride given in combinations and the analgesic efficacy of each single component in comparison to placebo on moderate to severe pain following impacted third mandibular molar tooth extraction. Ibuprofen will be used as an active control to validate the pain model.


Options:
A: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: Ibuprofen; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ibuprofen | Arm Label: TRAM.HCl high dose; Type: ACTIVE_COMPARATOR; Interventions: Drug: Tramadol Hydrochloride | Arm Label: TRAM.HCl low dose; Type: ACTIVE_COMPARATOR; Interventions: Drug: Tramadol Hydrochloride | Arm Label: DKP-TRIS high dose; Type: ACTIVE_COMPARATOR; Interventions: Drug: Dexketoprofen Trometamol | Arm Label: DKP-TRIS low dose; Type: ACTIVE_COMPARATOR; Interventions: Drug: Dexketoprofen Trometamol | Arm Label: DKP-TRIS low dose - TRAM.HCl low dose; Type: EXPERIMENTAL; Interventions: Drug: Dexketoprofen Trometamol + Tramadol Hydrochloride | Arm Label: DKP-TRIS low dose - TRAM.HCl high dose; Type: EXPERIMENTAL; Interventions: Drug: Dexketoprofen Trometamol + Tramadol Hydrochloride | Arm Label: DKP-TRIS high dose - TRAM.HCl low dose; Type: EXPERIMENTAL; Interventions: Drug: Dexketoprofen Trometamol + Tramadol Hydrochloride | Arm Label: DKP-TRIS high dose - TRAM.HCl high dose; Type: EXPERIMENTAL; Interventions: Drug: Dexketoprofen Trometamol + Tramadol Hydrochloride | Intervention Type: DRUG; Name: Dexketoprofen Trometamol; Assigned to Arm(s): DKP-TRIS low dose | Intervention Type: DRUG; Name: Dexketoprofen Trometamol; Assigned to Arm(s): DKP-TRIS high dose | Intervention Type: DRUG; Name: Tramadol Hydrochloride; Assigned to Arm(s): TRAM.HCl low dose | Intervention Type: DRUG; Name: Tramadol Hydrochloride; Assigned to Arm(s): TRAM.HCl high dose | Intervention Type: DRUG; Name: Ibuprofen; Assigned to Arm(s): Ibuprofen | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: Dexketoprofen Trometamol + Tramadol Hydrochloride; Assigned to Arm(s): DKP-TRIS low dose - TRAM.HCl low dose | Intervention Type: DRUG; Name: Dexketoprofen Trometamol + Tramadol Hydrochloride; Assigned to Arm(s): DKP-TRIS low dose - TRAM.HCl high dose | Intervention Type: DRUG; Name: Dexketoprofen Trometamol + Tramadol Hydrochloride; Assigned to Arm(s): DKP-TRIS high dose - TRAM.HCl low dose | Intervention Type: DRUG; Name: Dexketoprofen Trometamol + Tramadol Hydrochloride; Assigned to Arm(s): DKP-TRIS high dose - TRAM.HCl high dose
B: Arm Label: Maxigesic IV; Type: EXPERIMENTAL; Interventions: Drug: Maxigesic IV | Arm Label: IV Acetaminophen; Type: ACTIVE_COMPARATOR; Interventions: Drug: IV Acetaminophen | Arm Label: IV Ibuprofen; Type: ACTIVE_COMPARATOR; Interventions: Drug: IV Ibuprofen | Arm Label: Placebo IV; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo IV | Intervention Type: DRUG; Name: Maxigesic IV; Assigned to Arm(s): Maxigesic IV | Intervention Type: DRUG; Name: IV Acetaminophen; Assigned to Arm(s): IV Acetaminophen | Intervention Type: DRUG; Name: IV Ibuprofen; Assigned to Arm(s): IV Ibuprofen | Intervention Type: DRUG; Name: Placebo IV; Assigned to Arm(s): Placebo IV
C: Arm Label: intravenous ibuprofen; Type: ACTIVE_COMPARATOR; Interventions: Drug: Intravenous ibuprofen | Arm Label: normal saline; Type: PLACEBO_COMPARATOR; Interventions: Other: Normal saline as placebo comparator | Intervention Type: OTHER; Name: Normal saline as placebo comparator; Assigned to Arm(s): normal saline | Intervention Type: DRUG; Name: Intravenous ibuprofen; Assigned to Arm(s): intravenous ibuprofen
D: Arm Label: Caffeine-Ibuprofen; Type: OTHER; Interventions: Drug: ibuprofen, Drug: caffeine | Arm Label: Placebo-Ibuprofen/Caffeine; Type: OTHER; Interventions: Drug: ibuprofen + caffeine, Drug: placebo | Arm Label: Ibuprofen/Caffeine-Ibuprofen/Caffeine; Type: OTHER; Interventions: Drug: ibuprofen + caffeine | Arm Label: Ibuprofen-Ibuprofen; Type: OTHER; Interventions: Drug: ibuprofen | Arm Label: Caffeine-Ibuprofen/Caffeine; Type: OTHER; Interventions: Drug: caffeine, Drug: ibuprofen + caffeine | Arm Label: Placebo-Ibuprofen; Type: OTHER; Interventions: Drug: placebo, Drug: ibuprofen | Intervention Type: DRUG; Name: ibuprofen + caffeine; Assigned to Arm(s): Placebo-Ibuprofen/Caffeine | Intervention Type: DRUG; Name: ibuprofen; Assigned to Arm(s): Ibuprofen-Ibuprofen | Intervention Type: DRUG; Name: ibuprofen; Assigned to Arm(s): Caffeine-Ibuprofen | Intervention Type: DRUG; Name: caffeine; Assigned to Arm(s): Caffeine-Ibuprofen/Caffeine | Intervention Type: DRUG; Name: ibuprofen + caffeine; Assigned to Arm(s): Ibuprofen/Caffeine-Ibuprofen/Caffeine | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Placebo-Ibuprofen | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Placebo-Ibuprofen/Caffeine | Intervention Type: DRUG; Name: caffeine; Assigned to Arm(s): Caffeine-Ibuprofen | Intervention Type: DRUG; Name: ibuprofen; Assigned to Arm(s): Placebo-Ibuprofen | Intervention Type: DRUG; Name: ibuprofen + caffeine; Assigned to Arm(s): Caffeine-Ibuprofen/Caffeine

Answer: A