Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Multi-Center Phase II Study to Evaluate Tumor Response to Ipilimumab (BMS-734016) Monotherapy in Subjects With Melanoma Brain Metastases
Brief Summary: To assess the response of melanoma with brain metastases to ipilimumab treatment while maintaining acceptable tolerability.


Options:
A: Arm Label: BMS-936558 3 mg/kg (IV); Type: EXPERIMENTAL; Interventions: Biological: BMS-936558 | Arm Label: Investigator's Choice (Dacarbazine or Carboplatin+Paclitaxel); Type: ACTIVE_COMPARATOR; Interventions: Drug: Dacarbazine, Drug: Carboplatin, Drug: Paclitaxel | Intervention Type: BIOLOGICAL; Name: BMS-936558; Assigned to Arm(s): BMS-936558 3 mg/kg (IV) | Intervention Type: DRUG; Name: Dacarbazine; Assigned to Arm(s): Investigator's Choice (Dacarbazine or Carboplatin+Paclitaxel) | Intervention Type: DRUG; Name: Carboplatin; Assigned to Arm(s): Investigator's Choice (Dacarbazine or Carboplatin+Paclitaxel) | Intervention Type: DRUG; Name: Paclitaxel; Assigned to Arm(s): Investigator's Choice (Dacarbazine or Carboplatin+Paclitaxel)
B: Arm Label: Treatment (dabrafenib, trametinib, surgery); Type: EXPERIMENTAL; Interventions: Drug: Dabrafenib, Other: Laboratory Biomarker Analysis, Procedure: Therapeutic Conventional Surgery, Drug: Trametinib | Intervention Type: DRUG; Name: Dabrafenib; Assigned to Arm(s): Treatment (dabrafenib, trametinib, surgery) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Treatment (dabrafenib, trametinib, surgery) | Intervention Type: PROCEDURE; Name: Therapeutic Conventional Surgery; Assigned to Arm(s): Treatment (dabrafenib, trametinib, surgery) | Intervention Type: DRUG; Name: Trametinib; Assigned to Arm(s): Treatment (dabrafenib, trametinib, surgery)
C: Arm Label: Ipilimumab, 10 mg/kg, IV in corticosteroid-free patients; Type: EXPERIMENTAL; Interventions: Drug: Ipilimumab | Arm Label: Ipilimumab, 10 mg/kg, IV in corticosteroid-dependent patients; Type: EXPERIMENTAL; Interventions: Drug: Ipilimumab, Drug: Corticosteroid: Betamethasone, Drug: Corticosteroid: Dexamethasone, Drug: Corticosteroid: Fludrocortisone, Drug: Corticosteroid: Hydrocortisone, Drug: Corticosteroid: Meprednisone, Drug: Corticosteroid: Methylprednisolone, Drug: Corticosteroid: Prednisolone, Drug: Corticosteroid: Prednisone, Drug: Corticosteroid: Triamcinolone | Intervention Type: DRUG; Name: Ipilimumab; Assigned to Arm(s): Ipilimumab, 10 mg/kg, IV in corticosteroid-dependent patients, Ipilimumab, 10 mg/kg, IV in corticosteroid-free patients | Intervention Type: DRUG; Name: Corticosteroid: Betamethasone; Assigned to Arm(s): Ipilimumab, 10 mg/kg, IV in corticosteroid-dependent patients | Intervention Type: DRUG; Name: Corticosteroid: Dexamethasone; Assigned to Arm(s): Ipilimumab, 10 mg/kg, IV in corticosteroid-dependent patients | Intervention Type: DRUG; Name: Corticosteroid: Fludrocortisone; Assigned to Arm(s): Ipilimumab, 10 mg/kg, IV in corticosteroid-dependent patients | Intervention Type: DRUG; Name: Corticosteroid: Hydrocortisone; Assigned to Arm(s): Ipilimumab, 10 mg/kg, IV in corticosteroid-dependent patients | Intervention Type: DRUG; Name: Corticosteroid: Meprednisone; Assigned to Arm(s): Ipilimumab, 10 mg/kg, IV in corticosteroid-dependent patients | Intervention Type: DRUG; Name: Corticosteroid: Methylprednisolone; Assigned to Arm(s): Ipilimumab, 10 mg/kg, IV in corticosteroid-dependent patients | Intervention Type: DRUG; Name: Corticosteroid: Prednisolone; Assigned to Arm(s): Ipilimumab, 10 mg/kg, IV in corticosteroid-dependent patients | Intervention Type: DRUG; Name: Corticosteroid: Prednisone; Assigned to Arm(s): Ipilimumab, 10 mg/kg, IV in corticosteroid-dependent patients | Intervention Type: DRUG; Name: Corticosteroid: Triamcinolone; Assigned to Arm(s): Ipilimumab, 10 mg/kg, IV in corticosteroid-dependent patients
D: Arm Label: Arm A: Ipilimumab and Dacarbazine; Type: EXPERIMENTAL; Interventions: Drug: Ipilimumab, Drug: Dacarbazine | Arm Label: Arm B: Placebo and Dacarbazine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Placebo, Drug: Dacarbazine | Intervention Type: DRUG; Name: Ipilimumab; Assigned to Arm(s): Arm A: Ipilimumab and Dacarbazine | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Arm B: Placebo and Dacarbazine | Intervention Type: DRUG; Name: Dacarbazine; Assigned to Arm(s): Arm A: Ipilimumab and Dacarbazine, Arm B: Placebo and Dacarbazine

Answer: C