Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Maintaining Nonsmoking
Brief Summary: The research is based on a chronic disorder model of cigarette smoking which suggests that long-term treatment targeted to prevent relapse may be useful. Based on this model, the investigators have developed a relapse prevention treatment to intervene on five areas important in relapse prevention, including fluctuating motivation, depression, withdrawal, weight gain, and social support. This treatment protocol has produced high long-term abstinence rates when implemented in a clinical research setting. The current study will evaluate the treatment model when implemented in a medical outpatient setting.


Options:
A: Intervention Type: DRUG; Name: varenicline (CP-526,555); Assigned to Arm(s): N/A
B: Arm Label: 1, 26Wks, Counseling, CAM, AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling, Behavioral: Cognitive Medication Adherence Counseling (CAM), Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback, Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 2, 26Wks, Counseling, CAM, AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling, Behavioral: Cognitive Medication Adherence Counseling (CAM), Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 3, 26Wks, Counseling, CAM, No AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling, Behavioral: Cognitive Medication Adherence Counseling (CAM), Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback | Arm Label: 4, 26Wks, Counseling, CAM, No AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling, Behavioral: Cognitive Medication Adherence Counseling (CAM) | Arm Label: 5, 26Wks, Counseling, No CAM, AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling, Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback, Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 6, 26Wks, Counseling, No CAM, AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling, Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 7, 26Wks, Counseling, No CAM, No AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling, Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback | Arm Label: 8, 26Wks, Counseling, No CAM, No AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling | Arm Label: 9, 26Wks, No Counseling, CAM, AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Cognitive Medication Adherence Counseling (CAM), Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback, Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 10, 26Wks, No Counseling, CAM, AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Cognitive Medication Adherence Counseling (CAM), Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 11, 26Wks, No Counseling, CAM, No AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Cognitive Medication Adherence Counseling (CAM), Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback | Arm Label: 12, 26Wks, No Counseling, CAM, No AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Cognitive Medication Adherence Counseling (CAM) | Arm Label: 13, 26Wks, No Counseling, No CAM, AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback, Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 14, 26Wks, No Counseling, No CAM, AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 15, 26Wks, No Counseling, No CAM, No AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback | Arm Label: 16, 26Wks, No Counseling, No CAM, No AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum) | Arm Label: 17, 8Wks, Counseling, CAM, AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling, Behavioral: Cognitive Medication Adherence Counseling (CAM), Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback, Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 18, 8Wks, Counseling, CAM, AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling, Behavioral: Cognitive Medication Adherence Counseling (CAM), Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 19, 8Wks, Counseling, CAM, No AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling, Behavioral: Cognitive Medication Adherence Counseling (CAM), Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback | Arm Label: 20, 8Wks, Counseling, CAM, No AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling, Behavioral: Cognitive Medication Adherence Counseling (CAM) | Arm Label: 21, 8Wks, Counseling, No CAM, AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling, Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback, Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 22, 8Wks, Counseling, No CAM, AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling, Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 23, 8Wks, Counseling, No CAM, No AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling, Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback | Arm Label: 24, 8Wks, Counseling, No CAM, No AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Intensive Maintenance Counseling | Arm Label: 25, 8Wks, No Counseling, CAM, AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Cognitive Medication Adherence Counseling (CAM), Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback, Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 26, 8Wks, No Counseling, CAM, AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Cognitive Medication Adherence Counseling (CAM), Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 27, 8Wks, No Counseling, CAM, No AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Cognitive Medication Adherence Counseling (CAM), Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback | Arm Label: 28, 8Wks, No Counseling, CAM, No AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Cognitive Medication Adherence Counseling (CAM) | Arm Label: 29, 8Wks, No Counseling, No CAM, AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback, Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 30, 8Wks, No Counseling, No CAM, AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Automated Adherence Prompting Phone Calls | Arm Label: 31, 8Wks, No Counseling, No CAM, No AutoCalls, Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum), Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback | Arm Label: 32, 8Wks, No Counseling, No CAM, No AutoCalls, No Feedback; Type: EXPERIMENTAL; Interventions: Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum) | Intervention Type: DRUG; Name: Short Term Combination Nicotine Replacement Therapy (patch + gum); Assigned to Arm(s): 17, 8Wks, Counseling, CAM, AutoCalls, Feedback, 18, 8Wks, Counseling, CAM, AutoCalls, No Feedback, 19, 8Wks, Counseling, CAM, No AutoCalls, Feedback, 20, 8Wks, Counseling, CAM, No AutoCalls, No Feedback, 21, 8Wks, Counseling, No CAM, AutoCalls, Feedback, 22, 8Wks, Counseling, No CAM, AutoCalls, No Feedback, 23, 8Wks, Counseling, No CAM, No AutoCalls, Feedback, 24, 8Wks, Counseling, No CAM, No AutoCalls, No Feedback, 25, 8Wks, No Counseling, CAM, AutoCalls, Feedback, 26, 8Wks, No Counseling, CAM, AutoCalls, No Feedback, 27, 8Wks, No Counseling, CAM, No AutoCalls, Feedback, 28, 8Wks, No Counseling, CAM, No AutoCalls, No Feedback, 29, 8Wks, No Counseling, No CAM, AutoCalls, Feedback, 30, 8Wks, No Counseling, No CAM, AutoCalls, No Feedback, 31, 8Wks, No Counseling, No CAM, No AutoCalls, Feedback, 32, 8Wks, No Counseling, No CAM, No AutoCalls, No Feedback | Intervention Type: DRUG; Name: Long Term Combination Nicotine Replacement Therapy (patch + gum); Assigned to Arm(s): 1, 26Wks, Counseling, CAM, AutoCalls, Feedback, 10, 26Wks, No Counseling, CAM, AutoCalls, No Feedback, 11, 26Wks, No Counseling, CAM, No AutoCalls, Feedback, 12, 26Wks, No Counseling, CAM, No AutoCalls, No Feedback, 13, 26Wks, No Counseling, No CAM, AutoCalls, Feedback, 14, 26Wks, No Counseling, No CAM, AutoCalls, No Feedback, 15, 26Wks, No Counseling, No CAM, No AutoCalls, Feedback, 16, 26Wks, No Counseling, No CAM, No AutoCalls, No Feedback, 2, 26Wks, Counseling, CAM, AutoCalls, No Feedback, 3, 26Wks, Counseling, CAM, No AutoCalls, Feedback, 4, 26Wks, Counseling, CAM, No AutoCalls, No Feedback, 5, 26Wks, Counseling, No CAM, AutoCalls, Feedback, 6, 26Wks, Counseling, No CAM, AutoCalls, No Feedback, 7, 26Wks, Counseling, No CAM, No AutoCalls, Feedback, 8, 26Wks, Counseling, No CAM, No AutoCalls, No Feedback, 9, 26Wks, No Counseling, CAM, AutoCalls, Feedback | Intervention Type: BEHAVIORAL; Name: Intensive Maintenance Counseling; Assigned to Arm(s): 1, 26Wks, Counseling, CAM, AutoCalls, Feedback, 17, 8Wks, Counseling, CAM, AutoCalls, Feedback, 18, 8Wks, Counseling, CAM, AutoCalls, No Feedback, 19, 8Wks, Counseling, CAM, No AutoCalls, Feedback, 2, 26Wks, Counseling, CAM, AutoCalls, No Feedback, 20, 8Wks, Counseling, CAM, No AutoCalls, No Feedback, 21, 8Wks, Counseling, No CAM, AutoCalls, Feedback, 22, 8Wks, Counseling, No CAM, AutoCalls, No Feedback, 23, 8Wks, Counseling, No CAM, No AutoCalls, Feedback, 24, 8Wks, Counseling, No CAM, No AutoCalls, No Feedback, 3, 26Wks, Counseling, CAM, No AutoCalls, Feedback, 4, 26Wks, Counseling, CAM, No AutoCalls, No Feedback, 5, 26Wks, Counseling, No CAM, AutoCalls, Feedback, 6, 26Wks, Counseling, No CAM, AutoCalls, No Feedback, 7, 26Wks, Counseling, No CAM, No AutoCalls, Feedback, 8, 26Wks, Counseling, No CAM, No AutoCalls, No Feedback | Intervention Type: BEHAVIORAL; Name: Cognitive Medication Adherence Counseling (CAM); Assigned to Arm(s): 1, 26Wks, Counseling, CAM, AutoCalls, Feedback, 10, 26Wks, No Counseling, CAM, AutoCalls, No Feedback, 11, 26Wks, No Counseling, CAM, No AutoCalls, Feedback, 12, 26Wks, No Counseling, CAM, No AutoCalls, No Feedback, 17, 8Wks, Counseling, CAM, AutoCalls, Feedback, 18, 8Wks, Counseling, CAM, AutoCalls, No Feedback, 19, 8Wks, Counseling, CAM, No AutoCalls, Feedback, 2, 26Wks, Counseling, CAM, AutoCalls, No Feedback, 20, 8Wks, Counseling, CAM, No AutoCalls, No Feedback, 25, 8Wks, No Counseling, CAM, AutoCalls, Feedback, 26, 8Wks, No Counseling, CAM, AutoCalls, No Feedback, 27, 8Wks, No Counseling, CAM, No AutoCalls, Feedback, 28, 8Wks, No Counseling, CAM, No AutoCalls, No Feedback, 3, 26Wks, Counseling, CAM, No AutoCalls, Feedback, 4, 26Wks, Counseling, CAM, No AutoCalls, No Feedback, 9, 26Wks, No Counseling, CAM, AutoCalls, Feedback | Intervention Type: BEHAVIORAL; Name: Electronic Medication Monitoring Device (the Helping Hand) + Feedback; Assigned to Arm(s): 1, 26Wks, Counseling, CAM, AutoCalls, Feedback, 11, 26Wks, No Counseling, CAM, No AutoCalls, Feedback, 13, 26Wks, No Counseling, No CAM, AutoCalls, Feedback, 15, 26Wks, No Counseling, No CAM, No AutoCalls, Feedback, 17, 8Wks, Counseling, CAM, AutoCalls, Feedback, 19, 8Wks, Counseling, CAM, No AutoCalls, Feedback, 21, 8Wks, Counseling, No CAM, AutoCalls, Feedback, 23, 8Wks, Counseling, No CAM, No AutoCalls, Feedback, 25, 8Wks, No Counseling, CAM, AutoCalls, Feedback, 27, 8Wks, No Counseling, CAM, No AutoCalls, Feedback, 29, 8Wks, No Counseling, No CAM, AutoCalls, Feedback, 3, 26Wks, Counseling, CAM, No AutoCalls, Feedback, 31, 8Wks, No Counseling, No CAM, No AutoCalls, Feedback, 5, 26Wks, Counseling, No CAM, AutoCalls, Feedback, 7, 26Wks, Counseling, No CAM, No AutoCalls, Feedback, 9, 26Wks, No Counseling, CAM, AutoCalls, Feedback | Intervention Type: BEHAVIORAL; Name: Automated Adherence Prompting Phone Calls; Assigned to Arm(s): 1, 26Wks, Counseling, CAM, AutoCalls, Feedback, 10, 26Wks, No Counseling, CAM, AutoCalls, No Feedback, 13, 26Wks, No Counseling, No CAM, AutoCalls, Feedback, 14, 26Wks, No Counseling, No CAM, AutoCalls, No Feedback, 17, 8Wks, Counseling, CAM, AutoCalls, Feedback, 18, 8Wks, Counseling, CAM, AutoCalls, No Feedback, 2, 26Wks, Counseling, CAM, AutoCalls, No Feedback, 21, 8Wks, Counseling, No CAM, AutoCalls, Feedback, 22, 8Wks, Counseling, No CAM, AutoCalls, No Feedback, 25, 8Wks, No Counseling, CAM, AutoCalls, Feedback, 26, 8Wks, No Counseling, CAM, AutoCalls, No Feedback, 29, 8Wks, No Counseling, No CAM, AutoCalls, Feedback, 30, 8Wks, No Counseling, No CAM, AutoCalls, No Feedback, 5, 26Wks, Counseling, No CAM, AutoCalls, Feedback, 6, 26Wks, Counseling, No CAM, AutoCalls, No Feedback, 9, 26Wks, No Counseling, CAM, AutoCalls, Feedback
C: Arm Label: Extended Brief Contact; Type: EXPERIMENTAL; Interventions: Drug: Varenicline, Behavioral: Initial Individual counseling, Behavioral: Check-ins with medical staff | Arm Label: Extended Health Education; Type: EXPERIMENTAL; Interventions: Drug: Varenicline, Behavioral: Initial Individual counseling, Behavioral: Extended Individual Counseling - Health Model | Arm Label: Extended Relapse Prevention plus varenicline; Type: EXPERIMENTAL; Interventions: Drug: Varenicline, Behavioral: Initial Individual counseling, Behavioral: Extended Individual Counseling - Relapse Prevention Model | Arm Label: Extended Relapse Prevention; Type: EXPERIMENTAL; Interventions: Drug: Varenicline, Behavioral: Initial Individual counseling, Behavioral: Extended Individual Counseling - Relapse Prevention Model | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): Extended Brief Contact, Extended Health Education, Extended Relapse Prevention, Extended Relapse Prevention plus varenicline | Intervention Type: BEHAVIORAL; Name: Initial Individual counseling; Assigned to Arm(s): Extended Brief Contact, Extended Health Education, Extended Relapse Prevention, Extended Relapse Prevention plus varenicline | Intervention Type: BEHAVIORAL; Name: Check-ins with medical staff; Assigned to Arm(s): Extended Brief Contact | Intervention Type: BEHAVIORAL; Name: Extended Individual Counseling - Health Model; Assigned to Arm(s): Extended Health Education | Intervention Type: BEHAVIORAL; Name: Extended Individual Counseling - Relapse Prevention Model; Assigned to Arm(s): Extended Relapse Prevention, Extended Relapse Prevention plus varenicline
D: Arm Label: Varenicline; Type: EXPERIMENTAL; Interventions: Drug: Varenicline | Arm Label: Matched Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo for varenicline | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): Varenicline | Intervention Type: DRUG; Name: Placebo for varenicline; Assigned to Arm(s): Matched Placebo

Answer: C