Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Multicentric, Randomized, Open Label Study on Comparison of Pancreatic Beta Cell Recovery and Preservation in Type 2 Diabetic Patients Treated With DPP-4 Inhibitor (Vildagliptin) and Metformin
Brief Summary: This study is a multicentre, randomized, open label on comparison of pancreatic beta cell recovery and preservation of Vildagliptin 100mg daily and Metformin (1000 - 2500mg) daily for 96 weeks in 203 patients with type 2 diabetes that will be conducted in four centers in Chennai. The primary outcome measures will be to compare the effects of Vildagliptin versus Metformin on Pancreatic beta cell function in type 2 diabetic patients as measure by Insulin secretion rate (ISR) relative to glucose0-2hr (pmol/min/m2/mmol/L). The secondary outcomes will be effect of Vildagliptin versus Metformin based treatment on glycaemic variables in terms of Percent HbA1c reduction, C-peptide responses, Insulin to glucose ratios, Reduction in fasting plasma glucose (FPG), 2hr postprandial glucose (PPG) from baseline, Improvement in insulin sensitivity, Improvement in oral disposition index, Percentage of patients reaching the glycemic target of (i) HbA1c ≤ 6.5% and (ii)HbA1c ≤ 7.0%, in the overall study population and General safety in terms of occurrence of adverse events


Options:
A: Arm Label: Metformin; Type: PLACEBO_COMPARATOR; Interventions: Drug: Metformin 500 mg (ttd), Drug: Metformin 1000 mg (ttd), Drug: Metformin 1500 mg (ttd), Drug: Metformin 2000 mg (ttd) | Arm Label: Avandamet (Rosiglitazone maleate/metformin hydrochloride); Type: ACTIVE_COMPARATOR; Interventions: Drug: Avandamet 6 mg/1500 mg (ttd), Drug: Avandamet 4 mg/1000 mg (ttd), Drug: Avandamet 2 mg/500 mg (ttd), Drug: Avandamet 8 mg/ 2000 mg (ttd) | Intervention Type: DRUG; Name: Avandamet 6 mg/1500 mg (ttd); Assigned to Arm(s): Avandamet (Rosiglitazone maleate/metformin hydrochloride) | Intervention Type: DRUG; Name: Avandamet 4 mg/1000 mg (ttd); Assigned to Arm(s): Avandamet (Rosiglitazone maleate/metformin hydrochloride) | Intervention Type: DRUG; Name: Avandamet 2 mg/500 mg (ttd); Assigned to Arm(s): Avandamet (Rosiglitazone maleate/metformin hydrochloride) | Intervention Type: DRUG; Name: Avandamet 8 mg/ 2000 mg (ttd); Assigned to Arm(s): Avandamet (Rosiglitazone maleate/metformin hydrochloride) | Intervention Type: DRUG; Name: Metformin 500 mg (ttd); Assigned to Arm(s): Metformin | Intervention Type: DRUG; Name: Metformin 1000 mg (ttd); Assigned to Arm(s): Metformin | Intervention Type: DRUG; Name: Metformin 1500 mg (ttd); Assigned to Arm(s): Metformin | Intervention Type: DRUG; Name: Metformin 2000 mg (ttd); Assigned to Arm(s): Metformin
B: Arm Label: Metformin; Type: ACTIVE_COMPARATOR; Interventions: Drug: Metformin | Arm Label: Vildagliptin; Type: EXPERIMENTAL; Interventions: Drug: Vildagliptin | Intervention Type: DRUG; Name: Metformin; Assigned to Arm(s): Metformin | Intervention Type: DRUG; Name: Vildagliptin; Assigned to Arm(s): Vildagliptin
C: Arm Label: 1.5 mg LY2189265; Type: EXPERIMENTAL; Interventions: Drug: LY2189265, Drug: Insulin Lispro | Arm Label: 0.75 mg LY2189265; Type: EXPERIMENTAL; Interventions: Drug: LY2189265, Drug: Insulin Lispro | Arm Label: Insulin Glargine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Insulin Glargine, Drug: Insulin Lispro | Intervention Type: DRUG; Name: Insulin Glargine; Assigned to Arm(s): Insulin Glargine | Intervention Type: DRUG; Name: LY2189265; Assigned to Arm(s): 0.75 mg LY2189265, 1.5 mg LY2189265 | Intervention Type: DRUG; Name: Insulin Lispro; Assigned to Arm(s): 0.75 mg LY2189265, 1.5 mg LY2189265, Insulin Glargine
D: Arm Label: Sitagliptin; Type: ACTIVE_COMPARATOR; Interventions: Drug: Sitagliptin | Arm Label: Metformin; Type: ACTIVE_COMPARATOR; Interventions: Drug: Metformin | Arm Label: BI 10773 X mg; Type: EXPERIMENTAL; Interventions: Drug: BI 10773 | Arm Label: BI 10773 Y mg; Type: EXPERIMENTAL; Interventions: Drug: BI 10773 | Intervention Type: DRUG; Name: BI 10773; Assigned to Arm(s): BI 10773 Y mg | Intervention Type: DRUG; Name: Metformin; Assigned to Arm(s): Metformin | Intervention Type: DRUG; Name: BI 10773; Assigned to Arm(s): BI 10773 X mg | Intervention Type: DRUG; Name: Sitagliptin; Assigned to Arm(s): Sitagliptin

Answer: B