Please select the eligibility criteria that correspond to the clinical trial below.
Title: Hypnotics in the Treatment of Psychiatric Disorders
Brief Summary: This study will evaluate the safety and effectiveness of treatment with both a sleeping pill and antidepressant medication in improving sleep and psychological functioning in people with depression and insomnia.


Options:
A: Inclusion Criteria:

* Score of greater than 10 on the Primary Care Evaluation of Mental Disorders Patient Health Questionnaire (PRIME-MD-PHQ) telephone screen
* Diagnosis of major depressive episode based on the Structured Clinical Interview for DSM-IV (SCID)
* Score of greater than 20 on the Hamilton Rating Scale for Depression
* Meets research diagnostic criteria for insomnia disorder at least 4 nights per week
* Reported mean sleep latency greater than 30 minutes and mean sleep efficiency less than 85%
* Suitable for outpatient treatment

Exclusion Criteria:

* Use of any psychotropic medications within 2 weeks of initial screening
* Bipolar disorder, schizophrenia, psychotic depression, or any other psychotic disorder
* Uncontrolled asthma or chronic obstructive pulmonary disease
* Chronic pain that may be a significant sleep-disturbing factor
* Uncontrolled thyroid disease
* Poorly controlled diabetes mellitus
* Poorly compensated congestive heart failure
* Currently taking lipophilic beta blockers, opioids, glucocorticoids, theophylline, or other medications known to interfere with sleep
* History of intolerance or treatment resistance to either fluoxetine or eszopiclone
* Inability to abstain from taking any psychotropics other than the study medications during the course of the protocol, including sedating antihistamines
* Use of any herbal or naturopathic treatments for sleep or mood (i.e., St. John's wort, melatonin, kava kava, valerian root, etc.)
* Currently undergoing behavioral, cognitive-behavioral, or interpersonal therapy
* Pregnant or breastfeeding
* Agrees to use an effective form of contraception for the duration of the study
* Uncontrolled symptoms of menopause, including hot flashes
* Uncontrolled hypertension (systolic blood pressure consistently greater than 140 mm Hg, diastolic blood pressure consistently greater than 90 mm Hg)
* Diagnosis of sleep apnea, periodic limb movement disorder, or restless leg syndrome
* Reports habitual bedtime earlier than 9 PM or later than 1 AM more than 2 times per week
* Reports habitual rising time later than 9 AM more than 2 times per week
* Body mass index greater than 30
* Consumes more than 3 alcoholic beverages per day
* Consumes more than 4 caffeinated beverages per day
* Habitual smoking between 11 PM and 7 AM
* Use of illicit drugs
* Score greater than 24 on the Mini Mental State Examination
* Determined to be incompetent
* Determined to be at imminent risk for suicide
* More than 5 lifetime SCID diagnoses of major depressive episodes
* More than 3 failed antidepressant trials during the current episode of depression, as determined by the Antidepressant Treatment History Form
* A course of electroconvulsive therapy during the present depressive episode
B: Inclusion Criteria:

* Subject is male or female 6 to 17 years of age, inclusive, at the time of consent.
* Subject must have a diagnosis of ADHD as defined by DSM-IV criteria
* Subject must have documented ADHD associated insomnia, defined as the subject or subject's parent/legal guardian having reported repeated difficulty with sleep initiation (sleep latency \>30 minutes) or consolidation, (wake time after sleep onset \>45 minutes) despite adequate age appropriate time and opportunity for sleep.
* Subject's Baseline PSG must reveal either \>30 minutes latency to persistent sleep (LPS) or \>45 minutes wake after sleep onset (WASO).
* Subject or subject's parent/legal guardian should have reported daytime functional impairment as a result of sleep problems.
* Subject or subject's parent/legal guardian should have reported attempted and failed behavioral interventions for sleep problems, including a regular bedtime and rise time
* Subject's sleep disturbance must not be attributable to either the direct physiologic effect of a drug of abuse or misuse of a prescribed medication whether it is being used as intended or in an illicit manner.(Female subjects ≥8 years of age must have a negative serum pregnancy test)
* Subject must be in general good health
* Subject must be able to swallow tablets.
* If subject is currently taking medication for ADHD, they must be on a stable dose and regimen for a minimum of 1 month prior to the time of consent

Exclusion Criteria:

* Subject with weight \<10th percentile for age and gender
* Subject has any clinically significant or unstable medical illness/abnormality or chronic disease.
* Subject has a documented history of Bipolar I or II Disorder, major depression, conduct disorder, generalized anxiety disorder or any history of psychosis.
* Subject has periodic limb movement \>5 times per hour, as demonstrated on Baseline PSG.
* Subject has sleep disordered breathing, as demonstrated on Baseline PSG.
* Subject has another primary sleep disorder, a secondary sleep disorder, or any other known or suspected medical or psychiatric condition that has affected or may affect sleep
* Subject has a history of circadian rhythm disorder or will travel across ≥3 time zones more than once during the study.
* Subject has organic brain disease, or a history of febrile seizures.
* Subject is, in the opinion of the investigator, at suicidal or homicidal risk.
* Female subject who is pregnant or lactating or planning to become pregnant.
* Subject has taken any psychotropic medication without an appropriate washout period (≥5 half-lives) prior to randomization.
* Subject has a history of severe allergies to more than 1 class of medications or multiple adverse drug reactions.
* Subject has a history of allergic reaction or has a known or suspected sensitivity to racemic zopiclone, eszopiclone, or any substance that is contained in the formulation.
* Subject has a history of alcohol or substance abuse within 3 months of study participation.
C: Inclusion Criteria:

* All adult patients aged 18-65, evaluated by a sleep medicine provider in the Walter Reed Army Medical Center Sleep Disorders Clinic, who are referred for PSG for suspected Obstructive Sleep Apnea Syndrome

Exclusion Criteria:

* Pregnancy
* Liver dysfunction or history of EtOH abuse
* Concomitant use of benzodiazepines, narcotics or ketozonazole
* Decompensated CHF
* CVA within 3 months
* Uncontrolled psychiatric disorders
* Patients \< 18 years old
* Patients over 65
D: Inclusion Criteria:

* Male and female subjects with primary chronic insomnia. Subject is otherwise in good general health, based on screening physical examination and medical history.

Exclusion Criteria:

* Subject has recent history of known clinically significant abnormal laboratory findings.

Answer: A