Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Targeted Approaches to Weight Control for Young Adults
Brief Summary: Obesity represents a chronic disease associated with significant cardiovascular disease (CVD) morbidity and mortality. Weight gain in young adults adversely impacts the development of CVD risk factors. Further, there is a clear relationship between weight loss in obese persons and reduction in these CVD risk factors. Unfortunately, young adults are at high risk for weight gain. Although the scientific literature contains a number of reports regarding successful weight loss efficacy studies, young adults are typically underrepresented.

Cigarette smoking is the leading preventable cause of morbidity and mortality, but quitting smoking frequently results in significant weight gain. Proactive tobacco quit lines using behavioral smoking cessation interventions combined with nicotine replacement therapy (NRT) have been shown to help persons quit smoking. However, concerns about post-cessation weight gain have been reported as a significant barrier to quitting for many smokers particularly young adults.

If an efficacious behavioral weight loss program could be combined with an efficacious behavioral smoking cessation program that prevented or significantly attenuated post-cessation weight gain, then a large public health benefit may result. Such a combined weight loss/ weight gain prevention / smoking cessation program that used targeted intervention strategies to young adults, removed barriers to participation, and utilize interactive technology should be appealing to this age group. To date such a combined program has not been tested in young adult cigarette smokers. Therefore, the objective of this clinical trial is to develop and test a behavioral weight loss / weight gain prevention intervention delivered through interactive technology that can be used in conjunction with an efficacious tobacco quit line. A total of 330 participants will be necessary to adequately address the following specific aims.


Options:
A: Arm Label: Varenicline; Type: EXPERIMENTAL; Interventions: Drug: Varenicline | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): Varenicline | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
B: Arm Label: Tobacco Quitline Group; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Smoking Cessation | Arm Label: Tobacco Quitline plus Interactive Technology Group; Type: EXPERIMENTAL; Interventions: Behavioral: Smoking Cessation plus Weight Loss | Intervention Type: BEHAVIORAL; Name: Smoking Cessation; Assigned to Arm(s): Tobacco Quitline Group | Intervention Type: BEHAVIORAL; Name: Smoking Cessation plus Weight Loss; Assigned to Arm(s): Tobacco Quitline plus Interactive Technology Group
C: Arm Label: Control; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Smoking cessation | Arm Label: Simultaneous; Type: EXPERIMENTAL; Interventions: Behavioral: Weight gain prevention and smoking cessation | Arm Label: Sequential; Type: EXPERIMENTAL; Interventions: Behavioral: Weight gain prevention and smoking cessation | Intervention Type: BEHAVIORAL; Name: Weight gain prevention and smoking cessation; Assigned to Arm(s): Sequential, Simultaneous | Intervention Type: BEHAVIORAL; Name: Smoking cessation; Assigned to Arm(s): Control
D: Arm Label: Control; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Psychological advice, Drug: Bupropion Pill, Drug: Varenicline Pill | Arm Label: Intervention; Type: EXPERIMENTAL; Interventions: Other: So-Lo-Mo, Behavioral: Psychological advice, Drug: Bupropion Pill, Drug: Varenicline Pill | Intervention Type: OTHER; Name: So-Lo-Mo; Assigned to Arm(s): Intervention | Intervention Type: BEHAVIORAL; Name: Psychological advice; Assigned to Arm(s): Control, Intervention | Intervention Type: DRUG; Name: Bupropion Pill; Assigned to Arm(s): Control, Intervention | Intervention Type: DRUG; Name: Varenicline Pill; Assigned to Arm(s): Control, Intervention

Answer: B