Please select the eligibility criteria that correspond to the clinical trial below.
Title: Evaluation of the Utility of Indomethacin as Support Treatment in Women With Preterm Labor With Intact Membranes and High Risk of Intraamniotic Inflammation
Brief Summary: To demonstrate if indomethacin associated to conventional treatment for preterm labor is useful to delay delivery and to improve neonatal morbimortality in women with preterm labor with high risk of intraamniotic inflammation


Options:
A: Inclusion Criteria:

* BMI between (20 - 30 kg /m²).
* pregnant female with single viable fetus who presented to the outpatient clinic or Emergency room with the criteria of diagnosis of preterm labor between 28 and before completing 34 weeks pregnancy

Exclusion Criteria:

* - Any condition in which continuation of pregnancy will jeopardize maternal or fetal welfare.
* Cervix dilatation greater than 4 cm.
* Polyhydramnios \[amniotic fluid index (AFI) greater than 24 cm or deep vertical pocket more than 8 cm.\]
* Oligohydramnios (AFI less than 5 cm).
* Suspected intrauterine infection if Maternal fever is present as a constant feature plus one or more of the following:-

  * Maternal leucocytosis (more than 15,000)
  * purulent vaginal discharge
  * Fetal tachycardia more than 180 bpm.
* Growth restriction.
* Major antepartum hemorrhage
* Major maternal medical disorders such as diabetes, hypertension, systemic lupus,liver and kidney dysfunction .
* Multiple gestation pregnancy.
* Signs of fetal non reassuring CTG
* Signs of fetal abnormal CTG
* Lethal fetal anomaly incompatible with life.
* Premature Rupture of membrane.

  --Contraindication for the use of Nifedipine and/or Nicorandil such as drug allergy, cardiac disease, liver disease and kidney disease
* previous caesarean section
B: Inclusion Criteria:

* pregnant women with preterm labor admitted to hospital and treated with tocolysis
* pregnant women less than 28.0 and those women from 28.0 to 32.0 with a sonographic cervical length \< 15 mm
* single pregnancy
* normal amniotic fluid
* normal arterial ductus

Exclusion Criteria:

* Age below 18 years
* previous use of indomethacin in the index pregnancy
* chorioamnionitis, preterm prelabour rupture of membranes or those fetal or maternal pathologies which could be responsible of an iatrogenic preterm delivery.
* oligohydramnios
* allergy to NSAID
* previous history of gastrointestinal bleeding
* use of NSAID contraindicated
* not adherence to the study
C: Inclusion Criteria:

* Clinical diagnosis of preterm labour
* Women with singleton pregnancies

Exclusion Criteria:

* Women with preterm prelabour rupture of membranes
* Women with any indication for emergency delivery for whom prolongation of pregnancy is contraindicated
D: Inclusion Criteria:

1. Gestational age between 24 to 34 weeks which had been documented by a definite LMP and sonography up to 20 weeks.
2. All women fulfilled the criteria of preterm labor. The diagnosis of preterm labor required the presence of 4 uterine contractions or more over 30 minutes, each lasting at least 30 seconds, and documented cervical change. The cervical criteria were met when either of the following was present:

   1. Nulliparous women: a single cervical examination demonstrating dilatation of 0 cm to 4 cm and effacement of at least 50%
   2. Multiparous women: a single cervical examination demonstrating dilatation of 1 cm to 4 cm and effacement of at least 50%.
3. Provision of written informed consent

Exclusion Criteria:

1. Chorioamnionitis
2. Preterm rupture of membranes
3. Vaginal bleeding
4. Major fetal malformations
5. Severe hypertensive disorders
6. Intrauterine growth restriction (\< 5th percentile).
7. Non-reassuring fetal heart rate
8. Maternal contraindications

   1. Chronic hypertension
   2. Systolic blood pressure \< 90 mmHg
   3. Cardiovascular disease
   4. Elevated hepatic enzymes
9. Congenital or acquired uterine malformation

Answer: B