Please select the eligibility criteria that correspond to the clinical trial below.
Title: Prospective, Double-blind, Randomized Study to Evaluate a Single Shot Adductor Canal Nerve Block Versus Femoral Nerve Block Combined With LIA (Local Infiltration Analgesia): Early Postoperative Period Functional Outcomes After Total Knee Replacement
Brief Summary: The purpose of this study is to determine if patients undergoing a Total Knee Arthroplasty who receive a single shot Adductor Canal nerve block and local infiltration will have improved functional outcomes compared to individuals who receive a femoral nerve block and local infiltration during the first 24 hours post surgery.


Options:
A: Inclusion Criteria:

* TKA within 72 hours and VAS\>60 during 45 degrees active flexion of the knee despite conventional pain medication
* informed consent
* ASA 1-3
* BMI 18-40

Exclusion Criteria:

* Unable to communicate in Danish
* Allergic reactions toward ropivacaine
* Alcohol and or drug abuse
* Unable to cooperate
* Known sensory disturbances in the lower limbs
B: Inclusion Criteria:

* Patients for total knee arthroplasty having medicare insurance

Exclusion Criteria:

* Alcohol, drug abuser Narcotics addiction
C: Inclusion Criteria:

* Subject is 40-80 years of age and skeletally mature
* Subject BMI is \< 40
* Subject has been selected by the surgeon for TKA.
* Subject is taking less than 30 mg of Morphine per day.
* Subject is willing and able to sign a written consent form
* The subject has the mental capacity and the willingness to comply with the specified follow-up evaluations, and can be contacted by telephone by the site personnel.
* The subject is not pregnant, does not intend to become pregnant and has a significant other mirroring her intentions.

Exclusion Criteria:

* Subject is not neurologically intact (sensory, motor, and reflex deficit)
* Subject has pain in the limb scheduled for surgery that is out of proportion of expected pain usual for this pathology
* Subject scheduled for simultaneous bilateral knee replacement
* Subject has a history of any invasive malignancy (except non-melanoma skin cancer), unless treated with curative intent and with no clinical signs or symptoms of the malignancy for 5 years
* Subject with prior reconstructive knee surgery on the operated limb
* Subject with primary bone tumor in the knee area
* Subject anticipates having a lower extremity surgery other than the investigational surgery during the course of the study
* Subject has a history of substance abuse
* Subject is currently involved in another study or have received investigational product or treatment within the last 30 days
* Subject is pregnant or planning on becoming pregnant during the study period
* Subject is accepting workers' compensation
D: Inclusion Criteria:

* ASA I-III
* Age: 40-75
* Unilateral TKA
* Use of Spinal anesthesia

Exclusion Criteria:

* Allergy to any of the study medications
* Intolerance to morphine
* Contraindication to a spinal anesthetic
* Intraoperative use of any volatile anesthetic
* Chronic opioid use
* ASA Class 4-5
* Rheumatoid arthritis or Diabetes mellitus with neuropathy
* Liver or kidney failure
* BMI above 40
* Severe COPD

Answer: C