Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Combined Smoking Cessation and Cognitive Processing Therapy for PTSD
Brief Summary: Posttraumatic stress disorder (PTSD) and cigarette smoking are both associated with significant impairment in Veterans and cost to the Veterans' Affairs (VA) system. Though research suggests smoking is linked with PTSD symptoms, existing smoking cessation treatments targeting PTSD smokers do not include PTSD treatment. The purpose of this study is to examine a treatment that combines evidence based treatment for PTSD (cognitive processing therapy, or CPT) with smoking cessation treatment for PTSD and a mobile text messaging program. The study objectives are to evaluate feasibility of the treatment and to examine effectiveness of CPT and smoking cessation treatment combined compared to smoking cessation treatment without CPT. Fifty Veteran smokers with PTSD will participate in fourteen study sessions, ending with the final follow-up session six months after the scheduled quit date.


Options:
A: Intervention Type: DRUG; Name: varenicline (CP-526,555); Assigned to Arm(s): N/A
B: Arm Label: CPT+ICSC; Type: EXPERIMENTAL; Interventions: Behavioral: Cognitive Processing Therapy (CPT), Drug: Bupropion, Drug: nicotine replacement therapy (NRT), Behavioral: Integrated Care for Smoking Cessation (ICSC), Behavioral: smokefreeVET | Arm Label: ICSC only; Type: ACTIVE_COMPARATOR; Interventions: Drug: Bupropion, Drug: nicotine replacement therapy (NRT), Behavioral: Integrated Care for Smoking Cessation (ICSC), Behavioral: smokefreeVET | Intervention Type: BEHAVIORAL; Name: Cognitive Processing Therapy (CPT); Assigned to Arm(s): CPT+ICSC | Intervention Type: DRUG; Name: Bupropion; Assigned to Arm(s): CPT+ICSC, ICSC only | Intervention Type: DRUG; Name: nicotine replacement therapy (NRT); Assigned to Arm(s): CPT+ICSC, ICSC only | Intervention Type: BEHAVIORAL; Name: Integrated Care for Smoking Cessation (ICSC); Assigned to Arm(s): CPT+ICSC, ICSC only | Intervention Type: BEHAVIORAL; Name: smokefreeVET; Assigned to Arm(s): CPT+ICSC, ICSC only
C: Arm Label: Placebo (Slow Metabolizers); Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: Varenicline (Slow Metabolizers); Type: ACTIVE_COMPARATOR; Interventions: Drug: Varenicline | Arm Label: Transdermal Nicotine (Slow Metabolizers); Type: ACTIVE_COMPARATOR; Interventions: Drug: Transdermal Nicotine | Arm Label: Placebo (Normal Metabolizers); Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: Varenicline (Normal Metabolizers); Type: ACTIVE_COMPARATOR; Interventions: Drug: Varenicline | Arm Label: Transdermal Nicotine (Normal Metabolizers); Type: ACTIVE_COMPARATOR; Interventions: Drug: Transdermal Nicotine | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): Varenicline (Normal Metabolizers), Varenicline (Slow Metabolizers) | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo (Normal Metabolizers), Placebo (Slow Metabolizers) | Intervention Type: DRUG; Name: Transdermal Nicotine; Assigned to Arm(s): Transdermal Nicotine (Normal Metabolizers), Transdermal Nicotine (Slow Metabolizers)
D: Arm Label: Group Cognitive Behavioral Therapy; Type: EXPERIMENTAL; Interventions: Behavioral: Group Cognitive Behavioral Therapy, Drug: Transdermal Nicotine Patch | Arm Label: General Health Education; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: General Health Education, Drug: Transdermal Nicotine Patch | Intervention Type: BEHAVIORAL; Name: Group Cognitive Behavioral Therapy; Assigned to Arm(s): Group Cognitive Behavioral Therapy | Intervention Type: BEHAVIORAL; Name: General Health Education; Assigned to Arm(s): General Health Education | Intervention Type: DRUG; Name: Transdermal Nicotine Patch; Assigned to Arm(s): General Health Education, Group Cognitive Behavioral Therapy

Answer: B