Please select the eligibility criteria that correspond to the clinical trial below.
Title: Pathway Taking Into Account PeriConceptional Environment for Infertile Couple
Brief Summary: Infertility is defined as the inability to conceive after 12 months of unprotected intercourse, It affects approximately one in six couples pregnancy. Many lifestyle factors of the couple's pre and peri-conceptional environment (weight, diet, alcohol, tobacco, coffee, drugs, exercise, stress, sleep, pollution...) are risk factors for infertility. Weight gain, in both members of the couple, is associated with an increased risk of Assisted Reproduction Technology (ART) failure and adverse pregnancy outcome, while healthy lifestyle makes the risk of infertility three times less likely to happen. Idiopathic infertility may greatly benefit from lifestyle factors optimization.


Options:
A: Inclusion Criteria:

* Women aged from 18 to 40 years old.
* PCOS diagnosis (according to Rotterdam criteria).
* Mild or moderate male factor, tubal factor or unknown infertility.

Exclusion Criteria:

* Follicle stimulation hormone (third of day of menstruation) \> 10 milli international units/L.
* Endometriosis (III o IV).
* Congenital adrenal hyperplasia.
* Cushing syndrome.
* Hyperprolactinemia.
* Thyroid disease.
* Androgenic hormone secretor tumors.
* Patients included in this trial did not take either oral contraceptives, steroids or other medications that could modify the ovarian function, insulin sensitivity or lipid metabolism 3 months before the onset of the trial.
* Severe male factor (sperm concentration \< 5 mill/ml).
* Patients undergoing oocyte vitrification to avoid hyperstimulation syndrome will be excluded.
B: Inclusion Criteria:

* Diagnose of female infertility and indication for treatment with in vitro fertilization
* Body Mass Index (BMI) equal or greater than 30 kg/m² or BMI \> 25 kg/m² with increased waist circumference (\> 80 cm);
* Being not treated (diet) for weight loss/gain and maintaining stable body weight in the three months prior to the study;
* Not having stomach/digestive problems
* Not having the knowledge of cardiovascular disease history;
* Non-smokers;
* Not using any medication.

Exclusion Criteria:

* Patients with BMI equal or higher than 40 kg/m² (morbid obesity)
* Patients who are already receiving some type of nutritional intervention
* Patients with co-morbidities that may interfere with reproductive capacity (genetic and/or endocrine disorders, diabetes mellitus, cancer, liver or kidney failure), alcoholics, individuals who have contact (work) with heavy metals or chemicals (exposure to solvents and pesticides)
* Lack of adherence to the proposed dietary treatment
C: Inclusion Criteria:

* Infertile heterosexual couples about to start a first IVF-cycle (with or without ICSI) with infertility defined as the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse
* Women of couples aged ≤ 38 years
* Both partners possess a smartphone
* Both partners understand and speak Dutch
* Written informed consent after been informed on all aspects of the study

Exclusion Criteria:

* Couples with previous IVF/ICSI treatment cycles
* Couples where one of the partners has special dietary requirements including but not limited to patients that underwent bariatric surgery, patients with coeliac disease or renal disease
* Couples where one of the partners has specific movement's constraints including but not limited to patients with cerebral palsy or hemiparesis
* Couples starting IVF/ICSI with preimplantation genetic diagnosis (PGD)
* Couples using donor gametes or donor embryos
D: Inclusion Criteria:

* Couple attending a visit in an ART reproductive center (1st care regardless of the center regardless of the number of attempts in the center or in another center)
* Heterosexual infertile couple (absence of pregnancy after 12 months of unprotected intercourse)
* Men aged from 18 to 45 and women aged from 18 to 38
* Couple having not shown any opposition to the use of their data (observational study) and given their informed written consent to collect their biological samples
* Couple with good understanding of the French language
* Couple with computer equipment including webcam and internet access at home
* Affiliation to the French health insurance organism
* No-cons to the practice of adapted physical activity (non stabilized disease: diabetes, anemia, aplastic anemia, severe malnutrition, severe osteoporosis, heart or lung disease)
* Signing of the informed consent form

Exclusion Criteria:

* BMI upper 40 for one or both members of the couple
* Viral infection for one or both members of the couple (infection with HIV, Hepatitis B or C)
* Ongoing pregnancy
* One or both member of the couple medically treated for diabetes mellitus
* One or both member of the couple medically treated for a psychotic disorder
* Inability to comply with care program"
* Couple already enroll in the study

Answer: D