Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Long-term Varenicline Treatment for Smoking Cessation
Brief Summary: This is a clinical study of the efficacy and safety of up to 52 weeks of varenicline therapy in conjunction with individual counseling for smoking cessation. Adult volunteers in generally good health, smoking 5 or more cigarettes per day, will receive 13 weeks of open-label varenicline therapy. At 12 weeks after their target quit date, they will be assigned in a random, double-blind manner to either 40 additional weeks of varenicline or placebo. It is hypothesized that biochemically-confirmed abstinence rates will be higher for the varenicline group at 52 weeks. Participants will be followed for an additional 26 weeks post-treatment.


Options:
A: Arm Label: Extended treatment; Type: EXPERIMENTAL; Interventions: Drug: varenicline, Behavioral: Individual smoking cessation counseling | Arm Label: Standard treatment; Type: ACTIVE_COMPARATOR; Interventions: Drug: varenicline, Behavioral: Individual smoking cessation counseling | Intervention Type: DRUG; Name: varenicline; Assigned to Arm(s): Extended treatment, Standard treatment | Intervention Type: DRUG; Name: varenicline; Assigned to Arm(s): Extended treatment, Standard treatment | Intervention Type: BEHAVIORAL; Name: Individual smoking cessation counseling; Assigned to Arm(s): Extended treatment, Standard treatment
B: Arm Label: Participants; Type: N/A; Interventions: N/A
C: Arm Label: Bupropion SR; Type: ACTIVE_COMPARATOR; Interventions: Drug: Bupropion SR | Arm Label: Nicotine Patch; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine Patch | Arm Label: Placebo Patch and Placebo Pill; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo Patch and Placebo Pill | Arm Label: Delayed-quit control; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DRUG; Name: Bupropion SR; Assigned to Arm(s): Bupropion SR | Intervention Type: DRUG; Name: Nicotine Patch; Assigned to Arm(s): Nicotine Patch | Intervention Type: DRUG; Name: Placebo Patch and Placebo Pill; Assigned to Arm(s): Placebo Patch and Placebo Pill
D: Arm Label: High Intensity Counseling + Long Acting NRT + PRN NRT; Type: EXPERIMENTAL; Interventions: Drug: High Intensity Counseling + Long Acting NRT + PRN NRT | Arm Label: High Intensity Counseling + bupropion + PRN NRT; Type: EXPERIMENTAL; Interventions: Drug: High Intensity Counseling + bupropion + PRN NRT | Arm Label: High Intensity Counseling + varenicline + PRN NRT; Type: EXPERIMENTAL; Interventions: Drug: High Intensity Counseling + varenicline + PRN NRT | Arm Label: High Intensity Counseling + Long Acting NRT; Type: EXPERIMENTAL; Interventions: Drug: High Intensity Counseling + Long Acting NRT | Arm Label: High Intensity Counseling + bupropion; Type: EXPERIMENTAL; Interventions: Drug: High Intensity Counseling + bupropion | Arm Label: High Intensity Counseling + varenicline; Type: EXPERIMENTAL; Interventions: Drug: High Intensity Counseling + varenicline | Arm Label: Low Intensity Counseling + Long Acting NRT + PRN NRT; Type: EXPERIMENTAL; Interventions: Drug: Low Intensity Counseling + Long Acting NRT + PRN NRT | Arm Label: Low Intensity Counseling + bupropion + PRN NRT; Type: EXPERIMENTAL; Interventions: Drug: Low Intensity Counseling + bupropion + PRN NRT | Arm Label: Low Intensity Counseling + varenicline + PRN NRT; Type: EXPERIMENTAL; Interventions: Drug: Low Intensity Counseling + varenicline + PRN NRT | Arm Label: Low Intensity Counseling + Long Acting NRT; Type: EXPERIMENTAL; Interventions: Drug: Low Intensity Counseling + Long Acting NRT | Arm Label: Low Intensity Counseling + bupropion; Type: EXPERIMENTAL; Interventions: Drug: Low Intensity Counseling + bupropion | Arm Label: Low Intensity Counseling + varenicline; Type: EXPERIMENTAL; Interventions: Drug: Low Intensity Counseling + varenicline | Intervention Type: DRUG; Name: High Intensity Counseling + Long Acting NRT + PRN NRT; Assigned to Arm(s): High Intensity Counseling + Long Acting NRT + PRN NRT | Intervention Type: DRUG; Name: High Intensity Counseling + bupropion + PRN NRT; Assigned to Arm(s): High Intensity Counseling + bupropion + PRN NRT | Intervention Type: DRUG; Name: High Intensity Counseling + varenicline + PRN NRT; Assigned to Arm(s): High Intensity Counseling + varenicline + PRN NRT | Intervention Type: DRUG; Name: High Intensity Counseling + Long Acting NRT; Assigned to Arm(s): High Intensity Counseling + Long Acting NRT | Intervention Type: DRUG; Name: High Intensity Counseling + bupropion; Assigned to Arm(s): High Intensity Counseling + bupropion | Intervention Type: DRUG; Name: High Intensity Counseling + varenicline; Assigned to Arm(s): High Intensity Counseling + varenicline | Intervention Type: DRUG; Name: Low Intensity Counseling + Long Acting NRT + PRN NRT; Assigned to Arm(s): Low Intensity Counseling + Long Acting NRT + PRN NRT | Intervention Type: DRUG; Name: Low Intensity Counseling + bupropion + PRN NRT; Assigned to Arm(s): Low Intensity Counseling + bupropion + PRN NRT | Intervention Type: DRUG; Name: Low Intensity Counseling + varenicline + PRN NRT; Assigned to Arm(s): Low Intensity Counseling + varenicline + PRN NRT | Intervention Type: DRUG; Name: Low Intensity Counseling + Long Acting NRT; Assigned to Arm(s): Low Intensity Counseling + Long Acting NRT | Intervention Type: DRUG; Name: Low Intensity Counseling + bupropion; Assigned to Arm(s): Low Intensity Counseling + bupropion | Intervention Type: DRUG; Name: Low Intensity Counseling + varenicline; Assigned to Arm(s): Low Intensity Counseling + varenicline

Answer: A