Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase II Trial of Chemoradiotherapy and Local Excision for uT2uN0 Rectal Cancer
Brief Summary: RATIONALE: Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Oxaliplatin may make tumor cells more sensitive to radiation therapy. Giving capecitabine and oxaliplatin together with radiation therapy before surgery may shrink the tumor so it can be removed.

PURPOSE: This phase II trial is studying how well giving capecitabine and oxaliplatin together with radiation therapy works in treating patients who are undergoing surgery for stage I rectal cancer.


Options:
A: Arm Label: Total Mesorectal Excision; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Additional TME surgery | Arm Label: Adjuvant chemoradiotherapy; Type: EXPERIMENTAL; Interventions: Radiation: Adjuvant chemoradiotherapy, Drug: capecitabine | Intervention Type: RADIATION; Name: Adjuvant chemoradiotherapy; Assigned to Arm(s): Adjuvant chemoradiotherapy | Intervention Type: PROCEDURE; Name: Additional TME surgery; Assigned to Arm(s): Total Mesorectal Excision | Intervention Type: DRUG; Name: capecitabine; Assigned to Arm(s): Adjuvant chemoradiotherapy
B: Arm Label: Standard TME surgery; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Standard TME surgery | Arm Label: Long course concurrent chemoradiation; Type: EXPERIMENTAL; Interventions: Drug: Long course concurrent chemoradiation with capecitabine and radiotherapy | Arm Label: Short course radiotherapy; Type: EXPERIMENTAL; Interventions: Radiation: Short course radiotherapy | Intervention Type: PROCEDURE; Name: Standard TME surgery; Assigned to Arm(s): Standard TME surgery | Intervention Type: DRUG; Name: Long course concurrent chemoradiation with capecitabine and radiotherapy; Assigned to Arm(s): Long course concurrent chemoradiation | Intervention Type: RADIATION; Name: Short course radiotherapy; Assigned to Arm(s): Short course radiotherapy
C: Arm Label: Chemoradiotherapy+TEM; Type: ACTIVE_COMPARATOR; Interventions: Drug: Capecitabine (Xeloda), Radiation: 50.4 Gy, Procedure: Transanal Endoscopic Microsurgery | Arm Label: Total Mesorectal Excision; Type: OTHER; Interventions: Procedure: Total Mesorectal Excision | Intervention Type: DRUG; Name: Capecitabine (Xeloda); Assigned to Arm(s): Chemoradiotherapy+TEM | Intervention Type: RADIATION; Name: 50.4 Gy; Assigned to Arm(s): Chemoradiotherapy+TEM | Intervention Type: PROCEDURE; Name: Transanal Endoscopic Microsurgery; Assigned to Arm(s): Chemoradiotherapy+TEM | Intervention Type: PROCEDURE; Name: Total Mesorectal Excision; Assigned to Arm(s): Total Mesorectal Excision
D: Arm Label: Treatment (capecitabine, oxaliplatin, radiotherapy, surgery); Type: EXPERIMENTAL; Interventions: Drug: capecitabine, Drug: oxaliplatin, Procedure: neoadjuvant therapy, Radiation: radiation therapy | Intervention Type: DRUG; Name: capecitabine; Assigned to Arm(s): Treatment (capecitabine, oxaliplatin, radiotherapy, surgery) | Intervention Type: DRUG; Name: oxaliplatin; Assigned to Arm(s): Treatment (capecitabine, oxaliplatin, radiotherapy, surgery) | Intervention Type: PROCEDURE; Name: neoadjuvant therapy; Assigned to Arm(s): Treatment (capecitabine, oxaliplatin, radiotherapy, surgery) | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): Treatment (capecitabine, oxaliplatin, radiotherapy, surgery)

Answer: D