Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: The Effect of 30mcg and Levonorgestrel 150 Combined Oral Contraceptive, Etonogestrel-releasing Subdermal Implant and Levonorgestrel-releasing Intrauterine System on Breast-Milk Production and Infant Growth in Fully Breast-Feeding Women
Brief Summary: The investigators propose a randomized clinical trial comparing the effect of 30 mcg ethinyl estradiol and LNG 150 combination oral contraceptive pills versus placebo, or LNG-IUS or Etonogestrel-releasing contraceptive implant (Implanon)on breast-milk intake and infant growth in exclusively breastfeeding mother-infant pairs. Mother-infant pairs will be randomly assigned either 30 microgram ethinyl estradiol combination oral contraceptive pills or identical placebo to start on post-partum day number 42 or Implanon implants or a LNG-IUS. All women will be offered nonhormonal contraceptives prior to randomization. The pairs will then be followed for four weeks. During this follow-up period, breast-milk intake will be quantified by administering deuterium oxide to exclusively breast-feeding mothers and measuring the enrichment of deuterium oxide in the saliva of their infants, otherwise known as the dose-to-mother method of Coward.17 Additionally, maternal and infant anthropometric measurements will be collected -- both as a value necessary to implement the breast-milk quantification method, as well as an outcome for analysis, and a daily diary will be kept by the women participating in the study that records infant feeds and diaper changes.


Options:
A: Arm Label: Combined oral contraceptive; Type: ACTIVE_COMPARATOR; Interventions: Drug: 30 mcg EE and 150 LNG oral contraceptive (Microvlar), Device: TCu380A intrauterine device | Arm Label: Levonorgestrel intrauterine system; Type: ACTIVE_COMPARATOR; Interventions: Device: LNG-IUS, Device: TCu380A intrauterine device | Arm Label: Implanon; Type: ACTIVE_COMPARATOR; Interventions: Device: Implanon, Device: TCu380A intrauterine device | Arm Label: TCu380A intrauterine device; Type: ACTIVE_COMPARATOR; Interventions: Device: TCu380A copper-intrauterine device, Device: TCu380A intrauterine device | Intervention Type: DEVICE; Name: LNG-IUS; Assigned to Arm(s): Levonorgestrel intrauterine system | Intervention Type: DEVICE; Name: Implanon; Assigned to Arm(s): Implanon | Intervention Type: DRUG; Name: 30 mcg EE and 150 LNG oral contraceptive (Microvlar); Assigned to Arm(s): Combined oral contraceptive | Intervention Type: DEVICE; Name: TCu380A copper-intrauterine device; Assigned to Arm(s): TCu380A intrauterine device | Intervention Type: DEVICE; Name: TCu380A intrauterine device; Assigned to Arm(s): Combined oral contraceptive, Implanon, Levonorgestrel intrauterine system, TCu380A intrauterine device
B: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: Etonogestrel contraceptive implant | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Drug: Etonogestrel contraceptive implant | Intervention Type: DRUG; Name: Etonogestrel contraceptive implant; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Etonogestrel contraceptive implant; Assigned to Arm(s): 2
C: Arm Label: Study Arm A; Type: ACTIVE_COMPARATOR; Interventions: Drug: Combined estrogen-progestin pill | Arm Label: Study Arm B; Type: ACTIVE_COMPARATOR; Interventions: Drug: Progestin-only pill | Intervention Type: DRUG; Name: Combined estrogen-progestin pill; Assigned to Arm(s): Study Arm A | Intervention Type: DRUG; Name: Progestin-only pill; Assigned to Arm(s): Study Arm B
D: Arm Label: etonogestrel implant; Type: EXPERIMENTAL; Interventions: Drug: etonogestrel implant | Arm Label: depot medroxyprogesterone acetate; Type: ACTIVE_COMPARATOR; Interventions: Drug: depot medroxyprogesterone acetate | Intervention Type: DRUG; Name: etonogestrel implant; Assigned to Arm(s): etonogestrel implant | Intervention Type: DRUG; Name: depot medroxyprogesterone acetate; Assigned to Arm(s): depot medroxyprogesterone acetate

Answer: A