Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase II, Randomized, Parallel-group, Open-label, Multicenter Study to Evaluate the Effects of Rituximab on Immune Responses in Subjects With Active Rheumatoid Arthritis Receiving Background Methotrexate
Brief Summary: This was a Phase II, randomized, open-label, multicenter study designed to evaluate the immune response to vaccines after administration of 1000 mg of rituximab in subjects with active rheumatoid arthritis (RA) who were receiving background methotrexate (MTX).


Options:
A: Arm Label: Double-blind/Open Label Rituximab; Type: EXPERIMENTAL; Interventions: Biological: IDEC-C2B8 (rituximab), Drug: Methotrexate, Drug: Etanercept, Drug: Adalimumab, Drug: Methylprednisolone, Dietary Supplement: Folate | Arm Label: Double-blind Placebo/Open Label Rituximab; Type: OTHER; Interventions: Drug: Placebo, Drug: Methotrexate, Drug: Etanercept, Drug: Adalimumab, Drug: Methylprednisolone, Dietary Supplement: Folate | Intervention Type: BIOLOGICAL; Name: IDEC-C2B8 (rituximab); Assigned to Arm(s): Double-blind/Open Label Rituximab | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Double-blind Placebo/Open Label Rituximab | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): Double-blind Placebo/Open Label Rituximab, Double-blind/Open Label Rituximab | Intervention Type: DRUG; Name: Etanercept; Assigned to Arm(s): Double-blind Placebo/Open Label Rituximab, Double-blind/Open Label Rituximab | Intervention Type: DRUG; Name: Adalimumab; Assigned to Arm(s): Double-blind Placebo/Open Label Rituximab, Double-blind/Open Label Rituximab | Intervention Type: DRUG; Name: Methylprednisolone; Assigned to Arm(s): Double-blind Placebo/Open Label Rituximab, Double-blind/Open Label Rituximab | Intervention Type: DIETARY_SUPPLEMENT; Name: Folate; Assigned to Arm(s): Double-blind Placebo/Open Label Rituximab, Double-blind/Open Label Rituximab
B: Arm Label: Rituximab + methotrexate (Group A); Type: EXPERIMENTAL; Interventions: Drug: Rituximab, Drug: Methotrexate, Drug: Methylprednisone, Biological: C. albicans, Biological: Tetanus toxoid adsorbed booster vaccine, Biological: 23-valent pneumococcal polysaccharide vaccine, Biological: Keyhole limpet hemocyanin | Arm Label: Methotrexate (Group B); Type: ACTIVE_COMPARATOR; Interventions: Drug: Methotrexate, Biological: C. albicans, Biological: Tetanus toxoid adsorbed booster vaccine, Biological: 23-valent pneumococcal polysaccharide vaccine, Biological: Keyhole limpet hemocyanin | Intervention Type: DRUG; Name: Rituximab; Assigned to Arm(s): Rituximab + methotrexate (Group A) | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): Methotrexate (Group B), Rituximab + methotrexate (Group A) | Intervention Type: DRUG; Name: Methylprednisone; Assigned to Arm(s): Rituximab + methotrexate (Group A) | Intervention Type: BIOLOGICAL; Name: C. albicans; Assigned to Arm(s): Methotrexate (Group B), Rituximab + methotrexate (Group A) | Intervention Type: BIOLOGICAL; Name: Tetanus toxoid adsorbed booster vaccine; Assigned to Arm(s): Methotrexate (Group B), Rituximab + methotrexate (Group A) | Intervention Type: BIOLOGICAL; Name: 23-valent pneumococcal polysaccharide vaccine; Assigned to Arm(s): Methotrexate (Group B), Rituximab + methotrexate (Group A) | Intervention Type: BIOLOGICAL; Name: Keyhole limpet hemocyanin; Assigned to Arm(s): Methotrexate (Group B), Rituximab + methotrexate (Group A)
C: Arm Label: Placebo Plus Methotrexate; Type: PLACEBO_COMPARATOR; Interventions: Drug: Methotrexate, Other: Placebo | Arm Label: Rituximab plus Methotrexate; Type: EXPERIMENTAL; Interventions: Drug: MabThera/Rituxan, Drug: Methotrexate | Intervention Type: DRUG; Name: MabThera/Rituxan; Assigned to Arm(s): Rituximab plus Methotrexate | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): Placebo Plus Methotrexate, Rituximab plus Methotrexate | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo Plus Methotrexate
D: Arm Label: Rituximab (0.5 g x 2) + Methotrexate; Type: EXPERIMENTAL; Interventions: Drug: folate, Drug: methotrexate, Drug: methylprednisolone, Drug: rituximab | Arm Label: Rituximab (1.0 g x 2) + Methotrexate; Type: EXPERIMENTAL; Interventions: Drug: folate, Drug: methotrexate, Drug: methylprednisolone, Drug: rituximab | Arm Label: Placebo + Methotrexate; Type: PLACEBO_COMPARATOR; Interventions: Drug: folate, Drug: methotrexate, Drug: methylprednisolone, Drug: placebo | Intervention Type: DRUG; Name: folate; Assigned to Arm(s): Placebo + Methotrexate, Rituximab (0.5 g x 2) + Methotrexate, Rituximab (1.0 g x 2) + Methotrexate | Intervention Type: DRUG; Name: methotrexate; Assigned to Arm(s): Placebo + Methotrexate, Rituximab (0.5 g x 2) + Methotrexate, Rituximab (1.0 g x 2) + Methotrexate | Intervention Type: DRUG; Name: methylprednisolone; Assigned to Arm(s): Placebo + Methotrexate, Rituximab (0.5 g x 2) + Methotrexate, Rituximab (1.0 g x 2) + Methotrexate | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Placebo + Methotrexate | Intervention Type: DRUG; Name: rituximab; Assigned to Arm(s): Rituximab (0.5 g x 2) + Methotrexate, Rituximab (1.0 g x 2) + Methotrexate

Answer: B