Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Single-blind, Placebo-controlled, 4-Week Treatment Study of the Safety and Biologic Activity of Escalating Multiple Oral Doses of FG-4592 in Subjects With Chronic Kidney Disease Not Requiring Dialysis
Brief Summary: The primary objective of the study is to evaluate the safety, tolerability, and pharmacodynamic effects of different oral doses of roxadustat administered 2 times a week (BIW) or 3 times a week (TIW) for up to 4 weeks to participants with chronic kidney disease (CKD) not requiring dialysis.


Options:
A: Arm Label: Cohort A-1 (Roxadustat 1.0 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-2 (Roxadustat 1.5 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-3 (Roxadustat 2.0 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-4 (Roxadustat 1.8 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-5 (Roxadustat 1.8 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-6 (Roxadustat 1.3 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-7 (Weight Tiered Roxadustat 70-100-150 mg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-8 (Weight Tiered Roxadustat 70-120-200 mg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-9 (Roxadustat 2.0 mg/kg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort A-10 (Weight Tiered Roxadustat 70-120-200 mg); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohorts A (Epoetin Alfa); Type: ACTIVE_COMPARATOR; Interventions: Drug: Epoetin Alfa | Arm Label: Cohort B-1 (Roxadustat 1.5 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort B-2 (Roxadustat 2.0 mg/kg TIW); Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Cohort B (Epoetin Alfa); Type: ACTIVE_COMPARATOR; Interventions: Drug: Epoetin Alfa | Arm Label: Cohort B (Placebo); Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Intervention Type: DRUG; Name: Roxadustat; Assigned to Arm(s): Cohort A-1 (Roxadustat 1.0 mg/kg TIW), Cohort A-10 (Weight Tiered Roxadustat 70-120-200 mg), Cohort A-2 (Roxadustat 1.5 mg/kg TIW), Cohort A-3 (Roxadustat 2.0 mg/kg TIW), Cohort A-4 (Roxadustat 1.8 mg/kg TIW), Cohort A-5 (Roxadustat 1.8 mg/kg TIW), Cohort A-6 (Roxadustat 1.3 mg/kg TIW), Cohort A-7 (Weight Tiered Roxadustat 70-100-150 mg), Cohort A-8 (Weight Tiered Roxadustat 70-120-200 mg), Cohort A-9 (Roxadustat 2.0 mg/kg), Cohort B-1 (Roxadustat 1.5 mg/kg TIW), Cohort B-2 (Roxadustat 2.0 mg/kg TIW) | Intervention Type: DRUG; Name: Epoetin Alfa; Assigned to Arm(s): Cohort B (Epoetin Alfa), Cohorts A (Epoetin Alfa) | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Cohort B (Placebo)
B: Arm Label: Roxadustat; Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Roxadustat; Assigned to Arm(s): Roxadustat | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: Vadadustat; Type: EXPERIMENTAL; Interventions: Drug: Vadadustat | Arm Label: Darbepoetin alfa; Type: ACTIVE_COMPARATOR; Interventions: Drug: Darbepoetin alfa | Intervention Type: DRUG; Name: Vadadustat; Assigned to Arm(s): Vadadustat | Intervention Type: DRUG; Name: Darbepoetin alfa; Assigned to Arm(s): Darbepoetin alfa
D: Arm Label: Roxadustat 0.7 mg/kg BIW; Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Roxadustat 0.7 mg/kg TIW; Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Roxadustat 1.0 mg/kg BIW; Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Roxadustat 1.0 mg/kg TIW; Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Roxadustat 1.5 mg/kg BIW; Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Roxadustat 1.5 mg/kg TIW; Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Roxadustat 2.0 mg/kg BIW; Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Roxadustat 2.0 mg/kg TIW; Type: EXPERIMENTAL; Interventions: Drug: Roxadustat | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Roxadustat; Assigned to Arm(s): Roxadustat 0.7 mg/kg BIW, Roxadustat 0.7 mg/kg TIW, Roxadustat 1.0 mg/kg BIW, Roxadustat 1.0 mg/kg TIW, Roxadustat 1.5 mg/kg BIW, Roxadustat 1.5 mg/kg TIW, Roxadustat 2.0 mg/kg BIW, Roxadustat 2.0 mg/kg TIW | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo

Answer: D