Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Behavioral Smoking Cessation Treatment for People Living With HIV/AIDS
Brief Summary: In this proposed study with People Living with HIV/AIDS (PLWHA), we will use a stepped care model called a Sequential Multiple Assignment Randomized Trial (SMART) to examine the efficacy of low- and high-intensity smoking cessation treatments for nicotine dependent PLWHA that incorporate the current standard of care and prize-based contingency management. Intervention will be administered in a community-based HIV integrated care clinic in downtown Detroit, which has the highest prevalence rates of HIV/AIDS and smoking in Michigan. Phase 1 will last 4 weeks, and will involve brief intervention to help participants stop smoking. For phase 2, participants will be assigned to different study arms depending on whether they are Responders (reduced their smoking) or Non-responders (continued to smoke).

1. Phase 1: We hypothesize that brief high-magnitude prize contingency management will result in greater reduction in smoking than standard of care alone.
2. Phase 2a: We hypothesize that non-responders who are assigned to contingency management will be more likely to reduce their smoking throughout treatment and to abstain from smoking at all follow-up points.
3. Phase 2b: We hypothesize that responders who are assigned to monitoring and low-magnitude prize contingency management will be more likely to maintain their reduced or abstinent smoking status at all follow-up time-points.


Options:
A: Arm Label: Usual care; Type: PLACEBO_COMPARATOR; Interventions: Behavioral: Usual care | Arm Label: Lung Age; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Lung age | Arm Label: Contingency Management; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Contingency Management | Arm Label: Lung age + Contingency Management; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Lung age + Contingency Management | Intervention Type: BEHAVIORAL; Name: Usual care; Assigned to Arm(s): Usual care | Intervention Type: BEHAVIORAL; Name: Lung age; Assigned to Arm(s): Lung Age | Intervention Type: BEHAVIORAL; Name: Contingency Management; Assigned to Arm(s): Contingency Management | Intervention Type: BEHAVIORAL; Name: Lung age + Contingency Management; Assigned to Arm(s): Lung age + Contingency Management
B: Arm Label: Phase 1: Standard of Care (A); Type: EXPERIMENTAL; Interventions: Drug: Bupropion, Behavioral: Brief Counseling | Arm Label: Phase 1: Standard of Care (B); Type: EXPERIMENTAL; Interventions: Drug: Bupropion, Behavioral: Brief Counseling, Behavioral: High-magnitude prize contingency management | Arm Label: Phase 2a Non-Responders (A); Type: EXPERIMENTAL; Interventions: Drug: Bupropion, Behavioral: Brief Counseling, Behavioral: Monitored support to quit smoking | Arm Label: Phase 2a: Non-Responders (B); Type: EXPERIMENTAL; Interventions: Drug: Bupropion, Behavioral: Monitored support to quit smoking, Behavioral: Prize contingency management for abstinence | Arm Label: Phase 2b: Responders (A); Type: EXPERIMENTAL; Interventions: Drug: Bupropion, Behavioral: No additional treatment | Arm Label: Phase 2b: Responders (B); Type: EXPERIMENTAL; Interventions: Drug: Bupropion, Behavioral: Monitored support to quit smoking, Behavioral: Low intensity prize contingency management | Intervention Type: DRUG; Name: Bupropion; Assigned to Arm(s): Phase 1: Standard of Care (A), Phase 1: Standard of Care (B), Phase 2a Non-Responders (A), Phase 2a: Non-Responders (B), Phase 2b: Responders (A), Phase 2b: Responders (B) | Intervention Type: BEHAVIORAL; Name: Brief Counseling; Assigned to Arm(s): Phase 1: Standard of Care (A), Phase 1: Standard of Care (B), Phase 2a Non-Responders (A) | Intervention Type: BEHAVIORAL; Name: High-magnitude prize contingency management; Assigned to Arm(s): Phase 1: Standard of Care (B) | Intervention Type: BEHAVIORAL; Name: Monitored support to quit smoking; Assigned to Arm(s): Phase 2a Non-Responders (A), Phase 2a: Non-Responders (B), Phase 2b: Responders (B) | Intervention Type: BEHAVIORAL; Name: No additional treatment; Assigned to Arm(s): Phase 2b: Responders (A) | Intervention Type: BEHAVIORAL; Name: Prize contingency management for abstinence; Assigned to Arm(s): Phase 2a: Non-Responders (B) | Intervention Type: BEHAVIORAL; Name: Low intensity prize contingency management; Assigned to Arm(s): Phase 2b: Responders (B)
C: Arm Label: Original contingent vouchers schedule; Type: EXPERIMENTAL; Interventions: Behavioral: Voucher-based incentives | Arm Label: Revised contingent vouchers schedule; Type: EXPERIMENTAL; Interventions: Behavioral: Voucher-based incentives | Arm Label: Non-contingent vouchers schedule; Type: SHAM_COMPARATOR; Interventions: Behavioral: Voucher-based incentives | Intervention Type: BEHAVIORAL; Name: Voucher-based incentives; Assigned to Arm(s): Non-contingent vouchers schedule, Original contingent vouchers schedule, Revised contingent vouchers schedule
D: Arm Label: Group commitment contracts; Type: EXPERIMENTAL; Interventions: Behavioral: Group commitment contract, Behavioral: Smoking cessation education and counseling | Arm Label: Education and counseling; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Smoking cessation education and counseling | Intervention Type: BEHAVIORAL; Name: Group commitment contract; Assigned to Arm(s): Group commitment contracts | Intervention Type: BEHAVIORAL; Name: Smoking cessation education and counseling; Assigned to Arm(s): Education and counseling, Group commitment contracts

Answer: B