Please select the eligibility criteria that correspond to the clinical trial below.
Title: Reducing Hazardous Alcohol Use & Human Immunodeficiency Virus (HIV) Viral Load: A Randomized Controlled Trial (RCT) in Antiretroviral Therapy (ART) Clinics in Vietnam
Brief Summary: The purpose of this study is to compare the effectiveness of two interventions \[a Brief Intervention (BI) and a Motivational Enhancement Therapy+Cognitive Behavioral Therapy (MET+CBT) Intervention\], against each other and with an assessment-only control, in improving both alcohol- and HIV-related outcomes, among hazardous and heavy drinking HIV-infected antiretroviral therapy (ART) clinic clients in Thai Nguyen, Vietnam.


Options:
A: Inclusion Criteria:

* Female sex worker, defined as a woman who self reports exchange of any type of sex including oral, anal, and vaginal sex for money or gifts within the six months prior to study enrollment;
* Self-identifies as a woman;
* 18 years or older;
* Scores between 7-19 on the AUDIT questionnaire;
* Willing to participate in the study and all data collection procedures;
* Lives in Mombasa or plans on residing in Mombasa for 12 months following study enrollment;
* Currently participating in the APHIA II sex worker peer education program; and
* Documentation of negative tests for gonorrhea, Chlamydia, and trichomoniasis.

Exclusion Criteria:

* Scores less than 7 (low-risk drinking) or more than 19 (high-risk drinking/alcohol dependence) on the AUDIT questionnaire;
* Plans to be away in the next 12 months for more than six months or relocate away from the study site;
* Currently participating in another HIV intervention study; or
* Has any other condition that, in the opinion of the investigator or designee, would preclude provision of informed consent, make participation in the study unsafe, complicate interpretation of study outcome data, or otherwise with achieving the study objectives.
B: Inclusion Criteria:

* Men and women older than 18 years and 50 years
* Achieving a moderate risk score in the ASSIST screening questionnaire.
* Without any similar intervention in the last 3 months. (ie. AUDIT test).

Exclusion Criteria:

* Pregnant women.
* Users with cognitive disabilities.
* Users with language and communication disabilities.
C: Inclusion Criteria:

* Currently a client on ART at the clinic
* Hazardous drinking, measured using the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) instrument: AUDIT-C score \>= 4 for men, AUDIT-C score \>=3 for women
* Plan on residing in Thai Nguyen province for the next 24 months

Exclusion Criteria:

* Unwilling to provide informed consent
* Unable to participate in study activities due to psychological disturbance, cognitive impairment or threatening behavior
* Unwilling to provide locator information
* Currently participating in other HIV, drug use or alcohol programs or interventions
D: Inclusion Criteria:

* HIV-infected adult (≥18 years) prescribed antiretroviral therapy (ART) for at least 6 months;
* Current heavy alcohol use (AUDIT-C positive for prior 3 month drinking and positive EtG urine test);
* Positive tuberculin skin test (TST) (≥5 mm induration);
* AST and ALT \<2x the upper limit of normal (ULN);
* Fluent in Runyankole or English;
* No history of active TB, TB treatment, or TB preventive therapy;
* Lives within 2-hour travel time or 60 km of the study site.

Exclusion Criteria:

* Prescribed nevirapine (NVP, an ART drug that is declining in usage due to high risk for hepatotoxicity);
* Plans to move out of the catchment area within 6 months;
* Prescribed anti-convulsion medications or history of recurring seizures;
* ALT or AST elevations (\>2X ULN);
* Suspected or confirmed active TB as determined by symptom screening and followed by chest X-ray and sputum testing;
* History of prior active TB treatment or prior IPT.
* Pregnant at time of screening

Answer: C