Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase II Randomized Trial for Early-stage Squamous Cell Carcinoma of the Oropharynx: Radiotherapy vs Trans-oral Robotic Surgery (ORATOR)
Brief Summary: The historical standard treatment for early-stage squamous cell carcinoma of the oropharynx is radiation therapy. Some patients require chemotherapy with the radiation, and some patients require surgery if the tumour or lymph nodes have not responded after radiation.

This study will compare radiation therapy with a new surgical treatment called transoral robotic surgery (TORS). TORS is a new surgical approach using a robot to assist the surgeon in removing the tumour, potentially with fewer side effects than older surgical techniques.


Options:
A: Arm Label: Arm I; Type: ACTIVE_COMPARATOR; Interventions: Drug: cisplatin, Radiation: 3-dimensional conformal radiation therapy, Radiation: intensity-modulated radiation therapy | Arm Label: Arm II; Type: EXPERIMENTAL; Interventions: Biological: panitumumab, Radiation: 3-dimensional conformal radiation therapy, Radiation: accelerated radiation therapy, Radiation: intensity-modulated radiation therapy | Intervention Type: BIOLOGICAL; Name: panitumumab; Assigned to Arm(s): Arm II | Intervention Type: DRUG; Name: cisplatin; Assigned to Arm(s): Arm I | Intervention Type: RADIATION; Name: 3-dimensional conformal radiation therapy; Assigned to Arm(s): Arm I, Arm II | Intervention Type: RADIATION; Name: accelerated radiation therapy; Assigned to Arm(s): Arm II | Intervention Type: RADIATION; Name: intensity-modulated radiation therapy; Assigned to Arm(s): Arm I, Arm II
B: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: Docetaxel, Cisplatin, 5-fluorouracil (5-FU), radiotherapy | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Drug: Cisplatin, 5-fluorouracil (5-FU), radiotherapy | Arm Label: 3; Type: EXPERIMENTAL; Interventions: Other: Cisplatin + radiotherapy | Intervention Type: DRUG; Name: Docetaxel, Cisplatin, 5-fluorouracil (5-FU), radiotherapy; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Cisplatin, 5-fluorouracil (5-FU), radiotherapy; Assigned to Arm(s): 2 | Intervention Type: OTHER; Name: Cisplatin + radiotherapy; Assigned to Arm(s): 3
C: Intervention Type: BIOLOGICAL; Name: bleomycin sulfate; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: fluorouracil; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: leucovorin calcium; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: methotrexate; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: vincristine sulfate; Assigned to Arm(s): N/A | Intervention Type: RADIATION; Name: low-LET cobalt-60 gamma ray therapy; Assigned to Arm(s): N/A | Intervention Type: RADIATION; Name: low-LET photon therapy; Assigned to Arm(s): N/A | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): N/A
D: Arm Label: Radiotherapy plus or minus Chemotherapy; Type: ACTIVE_COMPARATOR; Interventions: Radiation: Radiotherapy | Arm Label: Transoral Robotic Surgery + Neck Dissection; Type: EXPERIMENTAL; Interventions: Procedure: Transoral Robotic Surgery + Neck Dissection | Intervention Type: RADIATION; Name: Radiotherapy; Assigned to Arm(s): Radiotherapy plus or minus Chemotherapy | Intervention Type: PROCEDURE; Name: Transoral Robotic Surgery + Neck Dissection; Assigned to Arm(s): Transoral Robotic Surgery + Neck Dissection

Answer: D