Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomised, Open-label Trial of a Multimodal Intervention (Exercise, Nutrition and Antiinflammatory Medication) Plus Standard Care Versus Standard Care Alone to Prevent/Attenuate Cachexia in Advanced Cancer Patients Undergoing Chemotherapy
Brief Summary: Cancer cachexia is a multi-factorial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment.

There is an urgency for improving management, but there is no consensus on the optimal treatment for cancer cachexia. Several single therapies for cancer cachexia have been examined in clinical trials, with disappointing overall results. As multiple factors are responsible for the development of cachexia, it has been argued that optimal cachexia interventions should target all components: multimodal therapy for a multimodal problem.

The overall aim of this study is to early prevent the development of cachexia rather than treatment late in the disease trajectory. From a patient perspective a short term effect will be to improve physical and psychological function, to reduce symptom burden and to improve survival. In other words live a longer and better life during and after chemotherapy. Direct effects of the cachexia intervention are expected to be reduction of weight and muscle loss, and improved physical activity and quality of life.


Options:
A: Arm Label: Training Group; Type: EXPERIMENTAL; Interventions: Other: Exercise | Arm Label: Control Group; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: OTHER; Name: Exercise; Assigned to Arm(s): Training Group
B: Arm Label: Exercise; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Physical exercise, Other: best supportive care | Arm Label: No exercise; Type: OTHER; Interventions: Other: best supportive care | Intervention Type: BEHAVIORAL; Name: Physical exercise; Assigned to Arm(s): Exercise | Intervention Type: OTHER; Name: best supportive care; Assigned to Arm(s): Exercise, No exercise
C: Arm Label: multimodal intervention; Type: EXPERIMENTAL; Interventions: Other: standard care, Other: nutritional supplements and advice, Other: home-based self-assisted exercise program, Drug: Ibuprofen | Arm Label: standard care; Type: ACTIVE_COMPARATOR; Interventions: Other: standard care | Intervention Type: OTHER; Name: standard care; Assigned to Arm(s): multimodal intervention, standard care | Intervention Type: OTHER; Name: nutritional supplements and advice; Assigned to Arm(s): multimodal intervention | Intervention Type: OTHER; Name: home-based self-assisted exercise program; Assigned to Arm(s): multimodal intervention | Intervention Type: DRUG; Name: Ibuprofen; Assigned to Arm(s): multimodal intervention
D: Arm Label: Immediate Lifestyle Intervention - Maintenance Program; Type: EXPERIMENTAL; Interventions: Behavioral: Lifestyle Intervention, Behavioral: Maintenance Intervention | Arm Label: Immediate Lifestyle Intervention - No Maintenance Program; Type: EXPERIMENTAL; Interventions: Behavioral: Lifestyle Intervention | Arm Label: Delayed Lifestyle Intervention - Maintenance Program; Type: EXPERIMENTAL; Interventions: Behavioral: Lifestyle Intervention, Behavioral: Maintenance Intervention | Arm Label: Delayed Lifestyle Intervention - No Maintenance Program; Type: EXPERIMENTAL; Interventions: Behavioral: Lifestyle Intervention | Intervention Type: BEHAVIORAL; Name: Lifestyle Intervention; Assigned to Arm(s): Delayed Lifestyle Intervention - Maintenance Program, Delayed Lifestyle Intervention - No Maintenance Program, Immediate Lifestyle Intervention - Maintenance Program, Immediate Lifestyle Intervention - No Maintenance Program | Intervention Type: BEHAVIORAL; Name: Maintenance Intervention; Assigned to Arm(s): Delayed Lifestyle Intervention - Maintenance Program, Immediate Lifestyle Intervention - Maintenance Program

Answer: C