Please select the eligibility criteria that correspond to the clinical trial below.
Title: Clinic, Family & Community Collaboration to Treat Overweight and Obese Children
Brief Summary: Stanford GOALS is a large-scale, community-based randomized controlled trial of an innovative, interdisciplinary, multi-component, multi-level, multi-setting (MMM) approach to treating overweight and obese children. Primary Research Question: Will a 3-year, innovative, interdisciplinary, multi-component, multi-level, multi-setting (MMM) community-based intervention to treat overweight and obese children significantly reduce BMI compared to an enhanced standard care/health and nutrition education active comparison intervention?


Options:
A: Inclusion Criteria:

* Parental consent
* 7.5-9.5 years
* Capable of performing exercise
* Absence of school-identified learning disability
* IQ \> 85
* Tanner Scales score \<= 2
* ADHD Rating Scales score \> 85%

Exclusion Criteria:

* Non-consent of guardian
* Above or Below age range
* Any physical disability that prohibits exercise
* School-identified learning disability
* IQ \< 85
* Tanner Scales Score \> 2
* ADHD Rating Scale score \< 85%
B: Inclusion Criteria:

* 7-11 years of age
* BMI greater than or equal to the 85th percentile for age and sex on the 2000 U.S. Centers for Disease Control and Prevention (CDC) BMI reference

Exclusion Criteria:

* Have been diagnosed with a medical condition affecting growth (a genetic or metabolic disease/syndrome associated with obesity, Type 1 diabetes, Type 2 diabetes taking medication, chronic gastrointestinal diseases, Chronic renal diseases, uncorrected structural heart disease, heart failure, heart transplant, anorexia nervosa or bulimia nervosa or binge eating disorder (present or past), AIDS or HIV infection, pregnancy);
* Take medications affecting growth (systemic corticosteroids more than 2 weeks in the past year, insulin, oral hypoglycemics, thyroid hormone, growth hormone);
* Have a condition limiting their participation in the interventions (e.g., unable to participate in routine physical education classes at school, requiring oxygen supplementation for exertion, developmental or physical disability preventing participation in interventions, children or parents/guardians who cannot medically participate in mild dietary restrictions and/or increased physical activity for any reason);
* Have a condition limiting participation in the assessments (child or primary caregiver not able to read surveys in English or Spanish, child two or more grade levels delayed in school for reading and writing in her native language);
* Are unable to read, understand or complete informed consent in English or Spanish;
* Plan to move from the San Francisco Bay Area within the next 36 months.
* Are deemed to have another characteristic that makes them unsuitable for participation in the study in the judgment of the Principal Investigator.
C: Inclusion Criteria:

* Preadolescent children of Tanner stage of I, II or III.
* Children of 8 to 11 years-old,
* Overweight or obese defined based on the sex-and-age specific body mass index standards of Cole (2002).
* Girls must not have menstruation.

Exclusion Criteria:

* Children with Attention-Deficit Hyperactivity Disorder or any other psychiatric disorder.
* Left-handed children.
* Children with medical problem that prevent to practice physical activity.
D: Inclusion Criteria:

* BMI \> 27 kg/m2 (adults)

Exclusion Criteria:

* weight loss of more than 5kg in the last 2 months
* pregnancy, breastfeeding
* patients with:

  * severe heart failure
  * impaired hepatic or renal function
  * anaemia
  * disturbed coagulation (biopsies will not be taken in those subjects)
  * infection, malabsorption
  * severe hypertension
  * cancer within the last 5 years
  * eating disorders or any other psychiatric condition that would interact with the trial intervention
  * any other endocrine disorder
* changes of smoking habits or diets within the last 3 months prior to study inclusion

Answer: B