Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Pragmatic Investigation of optimaL Oxygen Targets (PILOT) Trial
Brief Summary: Mechanical ventilation of ICU patients universally involves titration of the fraction of inspired oxygen (FiO2) to maintain arterial oxygen saturation (SpO2). Despite decades of ICU practice, however, the optimal SpO2 target remains unknown. Current guidelines offer divergent recommendations as to the optimal SpO2 target. Therefore, we propose a 2,250-patient cluster-randomized cluster-crossover trial comparing a lower SpO2 target (90%; range 88-92%), an intermediate SpO2 target (94%; range 92-96%), and a higher SpO2 target (98%; range 96-100%) with regard to the outcome of days alive and free of invasive mechanical ventilation.


Options:
A: Arm Label: Low normal MAP and low normal PaO2; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal MAP, Other: Low normal PaO2. | Arm Label: High normal MAP and low normal PaO2; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal MAP, Other: Low normal PaO2. | Arm Label: Low normal MAP and high normal PaO2; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal MAP, Other: High normal PaO2 | Arm Label: High normal MAP and high normal PaO2; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal MAP, Other: Low normal PaO2. | Intervention Type: OTHER; Name: Low normal MAP; Assigned to Arm(s): Low normal MAP and high normal PaO2, Low normal MAP and low normal PaO2 | Intervention Type: OTHER; Name: High normal MAP; Assigned to Arm(s): High normal MAP and high normal PaO2, High normal MAP and low normal PaO2 | Intervention Type: OTHER; Name: Low normal PaO2.; Assigned to Arm(s): High normal MAP and high normal PaO2, High normal MAP and low normal PaO2, Low normal MAP and low normal PaO2 | Intervention Type: OTHER; Name: High normal PaO2; Assigned to Arm(s): Low normal MAP and high normal PaO2
B: Arm Label: Oxygen reduction; Type: EXPERIMENTAL; Interventions: Drug: Oxygen | Arm Label: Standard Care; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oxygen | Intervention Type: DRUG; Name: Oxygen; Assigned to Arm(s): Oxygen reduction, Standard Care
C: Arm Label: Group 1; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: Low normal PaO2, Other: Low normal MAP | Arm Label: Group 2; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: Low normal PaO2, Other: Low normal MAP | Arm Label: Group 3; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: High normal PaO2, Other: Low normal MAP | Arm Label: Group 4; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: High normal PaO2, Other: Low normal MAP | Arm Label: Group 5; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: Low normal PaO2, Other: High normal MAP | Arm Label: Group 6; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: Low normal PaO2, Other: High normal MAP | Arm Label: Group 7; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: High normal PaO2, Other: High normal MAP | Arm Label: Group 8; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: High normal PaO2, Other: High normal MAP | Intervention Type: OTHER; Name: Low normal PaCO2; Assigned to Arm(s): Group 1, Group 3, Group 5, Group 7 | Intervention Type: OTHER; Name: High normal PaCO2; Assigned to Arm(s): Group 2, Group 4, Group 6, Group 8 | Intervention Type: OTHER; Name: Low normal PaO2; Assigned to Arm(s): Group 1, Group 2, Group 5, Group 6 | Intervention Type: OTHER; Name: High normal PaO2; Assigned to Arm(s): Group 3, Group 4, Group 7, Group 8 | Intervention Type: OTHER; Name: Low normal MAP; Assigned to Arm(s): Group 1, Group 2, Group 3, Group 4 | Intervention Type: OTHER; Name: High normal MAP; Assigned to Arm(s): Group 5, Group 6, Group 7, Group 8
D: Arm Label: Lower SpO2 Target; Type: ACTIVE_COMPARATOR; Interventions: Other: Lower SpO2 Target | Arm Label: Intermediate SpO2 Target; Type: ACTIVE_COMPARATOR; Interventions: Other: Intermediate SpO2 Target | Arm Label: Higher SpO2 Target; Type: ACTIVE_COMPARATOR; Interventions: Other: Higher SpO2 Target | Intervention Type: OTHER; Name: Lower SpO2 Target; Assigned to Arm(s): Lower SpO2 Target | Intervention Type: OTHER; Name: Intermediate SpO2 Target; Assigned to Arm(s): Intermediate SpO2 Target | Intervention Type: OTHER; Name: Higher SpO2 Target; Assigned to Arm(s): Higher SpO2 Target

Answer: D