Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase 2, MultiCenter, Randomized, Placebo-Controlled, Double-Blind, Dose Finding Study to Determine the Safety and Efficacy of SCH 619734 for the Treatment of Chemotherapy Induced Nausea and Vomiting (CINV) in Subjects Receiving Highly Emetogenic Chemotherapy (HEC)
Brief Summary: This is a Phase 2, randomized, multicenter, parallel-group, double-blind, placebo-controlled study of various doses of SCH 619734 in subjects receiving cisplatin-based chemotherapy. Ondansetron and dexamethasone will be concurrently administered with SCH 619734 before initiation of chemotherapy on Day 1. Subjects will record nausea and vomiting in the SPNV Subject Diary through Day 6. The quality of life assessment as measured by the Functional Living Index-Emesis Questionnaire (FLIE) will be used to measure the effect of chemotherapy-induced nausea and vomiting (CINV) on daily life. Blood samples for SCH 619734 pharmacokinetic assessments will be collected. The study is to be conducted in conformance with Good Clinical Practice.


Options:
A: Arm Label: Arm A: Aprepitant, Then Placebo; Type: EXPERIMENTAL; Interventions: Drug: Aprepitant, Drug: Placebo | Arm Label: Arm B: Placebo, Then Aprepitant; Type: EXPERIMENTAL; Interventions: Drug: Aprepitant, Drug: Placebo | Intervention Type: DRUG; Name: Aprepitant; Assigned to Arm(s): Arm A: Aprepitant, Then Placebo, Arm B: Placebo, Then Aprepitant | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Arm A: Aprepitant, Then Placebo, Arm B: Placebo, Then Aprepitant
B: Arm Label: Control; Type: PLACEBO_COMPARATOR; Interventions: Drug: Dexamethasone, Drug: Placebo, Drug: Ondansetron | Arm Label: Single Dose IV; Type: EXPERIMENTAL; Interventions: Drug: Casopitant, Drug: Dexamethasone, Drug: Ondansetron | Intervention Type: DRUG; Name: Casopitant; Assigned to Arm(s): Single Dose IV | Intervention Type: DRUG; Name: Dexamethasone; Assigned to Arm(s): Control, Single Dose IV | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Control | Intervention Type: DRUG; Name: Ondansetron; Assigned to Arm(s): Control, Single Dose IV
C: Arm Label: SCH 619734 Dose 1; Type: EXPERIMENTAL; Interventions: Drug: SCH 619734 Dose 1 | Arm Label: SCH 619734 Dose 2; Type: EXPERIMENTAL; Interventions: Drug: SCH 619734 Dose 2 | Arm Label: SCH 619734 Dose 3; Type: EXPERIMENTAL; Interventions: Drug: SCH 619734 Dose 3 | Arm Label: SCH 619734 Dose 4; Type: EXPERIMENTAL; Interventions: Drug: SCH 619734 Dose 4 | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: SCH 619734 Dose 1; Assigned to Arm(s): SCH 619734 Dose 1 | Intervention Type: DRUG; Name: SCH 619734 Dose 2; Assigned to Arm(s): SCH 619734 Dose 2 | Intervention Type: DRUG; Name: SCH 619734 Dose 3; Assigned to Arm(s): SCH 619734 Dose 3 | Intervention Type: DRUG; Name: SCH 619734 Dose 4; Assigned to Arm(s): SCH 619734 Dose 4 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
D: Arm Label: Arm I; Type: ACTIVE_COMPARATOR; Interventions: Drug: dexamethasone, Drug: palonosetron hydrochloride, Drug: prochlorperazine, Drug: placebo | Arm Label: Arm II; Type: EXPERIMENTAL; Interventions: Drug: dexamethasone, Drug: granisetron hydrochloride, Drug: prochlorperazine, Drug: placebo | Arm Label: Arm III; Type: ACTIVE_COMPARATOR; Interventions: Drug: aprepitant, Drug: dexamethasone, Drug: palonosetron hydrochloride, Drug: placebo | Arm Label: Arm IV; Type: EXPERIMENTAL; Interventions: Drug: dexamethasone, Drug: palonosetron hydrochloride, Drug: prochlorperazine, Drug: placebo | Intervention Type: DRUG; Name: aprepitant; Assigned to Arm(s): Arm III | Intervention Type: DRUG; Name: dexamethasone; Assigned to Arm(s): Arm I, Arm II, Arm III, Arm IV | Intervention Type: DRUG; Name: granisetron hydrochloride; Assigned to Arm(s): Arm II | Intervention Type: DRUG; Name: palonosetron hydrochloride; Assigned to Arm(s): Arm I, Arm III, Arm IV | Intervention Type: DRUG; Name: prochlorperazine; Assigned to Arm(s): Arm I, Arm II, Arm IV | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Arm I, Arm II, Arm III, Arm IV

Answer: C