Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Recurrent Urinary Tract Infections in Adult Women: a Pilot Study With Oral D Mannose
Brief Summary: Background- In recurrent urinary tract infections (RUTIs) usual prophylactic antibiotic regimes do not change the long term risk of recurrence.

Objective- D-Mannose is a sugar, it sticks to E. coli bacteria, the aim of the study was to evaluate its efficacy in the treatment and prophylaxis of recurrent UTIs.

Design, setting and participants- : In this crossover trial female patient were eligible for the study if they had recurrent UTIs, that is three ore more episodes during the preceding 12 months. Suitable patients were randomly assigned to antibiotic treatment with trimethoprim/sulfamethoxazole or to a regimen of oral D Mannose for 24 weeks, and received the other intervention in the second phase of the study.

Outcome measurements and statistical analysis- The time to recurrence of UTI, bladder pain (VAS p) and urinary urgency (VAS u) were evaluated at the end of antibiotic therapy and at the and of 24 weeks fo D Mannose. The results for quantitative variables were expressed as mean values and SD as they were all normally distributed (Shapiro-Wilk test). T-test for paired data was used to analyze differences of time of recurrence, VAS pain, Vas urgency and number of voidings between treatment. Data analysis was performed with STATA statistical package (release 11,1, 2010, Stata Corporation, College Station, Texas, USA).


Options:
A: Arm Label: Methenamine augmentation; Type: EXPERIMENTAL; Interventions: Drug: Methenamine Hippurate 1000 MG, Drug: Vaginal estrogen, Dietary Supplement: D-mannose | Arm Label: No methenamine augmentation; Type: ACTIVE_COMPARATOR; Interventions: Drug: Vaginal estrogen, Dietary Supplement: D-mannose | Intervention Type: DRUG; Name: Methenamine Hippurate 1000 MG; Assigned to Arm(s): Methenamine augmentation | Intervention Type: DRUG; Name: Vaginal estrogen; Assigned to Arm(s): Methenamine augmentation, No methenamine augmentation | Intervention Type: DIETARY_SUPPLEMENT; Name: D-mannose; Assigned to Arm(s): Methenamine augmentation, No methenamine augmentation
B: Arm Label: D Mannose; Type: EXPERIMENTAL; Interventions: Dietary Supplement: D Mannose, Drug: trimethoprim/sulfamethoxazole | Arm Label: trimethoprim/sulfamethoxazole; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: D Mannose, Drug: trimethoprim/sulfamethoxazole | Intervention Type: DIETARY_SUPPLEMENT; Name: D Mannose; Assigned to Arm(s): D Mannose, trimethoprim/sulfamethoxazole | Intervention Type: DRUG; Name: trimethoprim/sulfamethoxazole; Assigned to Arm(s): D Mannose, trimethoprim/sulfamethoxazole
C: Arm Label: mannose; Type: EXPERIMENTAL; Interventions: Drug: Mannose | Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Lactose | Intervention Type: DRUG; Name: Mannose; Assigned to Arm(s): mannose | Intervention Type: DRUG; Name: Lactose; Assigned to Arm(s): placebo
D: Arm Label: Treatment; Type: EXPERIMENTAL; Interventions: Dietary Supplement: WelTract | Arm Label: Control; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: WelTract; Assigned to Arm(s): Treatment | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo; Assigned to Arm(s): Control

Answer: B