Please select the eligibility criteria that correspond to the clinical trial below.
Title: CABG Off or On Pump Revascularization Study (CORONARY)
Brief Summary: I. Main Research Question:

* To compare the risks and benefits of Off-pump Coronary artery bypass surgery (CABG) to On-pump CABG and to determine if one is better than the other.
* The purpose of this pilot study is also to see the rate of recruitment with expertise-based randomization across different hospital settings.

II. Small RCT studies and meta-analyses done so far have not been able to conclusively say which of the procedure is better. A large randomized study is required to establish the risks and benefits associated with both the off-pump and on-pump CABG surgical procedures.

III. The study will look at which of the two techniques reduce major risks associated with CABG.


Options:
A: Inclusion Criteria:

* Patients with coronary artery disease confirmed by coronary angiography.
* Patients undergoing cardiac surgery such as elective coronary bypass artery grafting (CABG), valve replacement or aortic surgery.
* All patients will not be under statins treatment for at least 6 months before their inclusion to the study.

Exclusion Criteria:

* Acute coronary syndrome during the last 2 months
* Renal failure (creatinine \> 2,2 mg/dl)
* Severe liver disease. Prospective follow-up of liver enzymes will be performed by the physicians in charge, as indicated by the relative guidelines regarding statins use and according to the current clinical practice.
* Any chronic/acute inflammatory disease, autoimmune disease and/or cancer
* Use of anti-inflammatory drugs or vitamins supplements
B: Inclusion Criteria:

* consecutive patients scheduled for the elective off-pump CABG surgery

Exclusion Criteria:

* prior statin use
* previous episodes of atrial fibrillation
* impaired renal function with serum creatinine \>2mg/dL
* serum aspartate aminotransferase or alanine aminotransferase concentrations more than 3 times the upper limit of normal
* a malignancy or inflammatory disease
C: Inclusion Criteria:

Patients who have been diagnosed with coronary artery disease (single, double or triple disease) will be eligible if they:

1. require isolated CABG with median sternotomy
2. are able to give their informed written consent
3. are\> 21 years of age and
4. have one or more of the following risk factors:

   * ≥ 70 years
   * peripheral vascular disease (previous peripheral bypass or amputation or ABI \<0.80)
   * Cerebrovascular disease (history of stroke, TIA)
   * Renal insufficiency (creatinine above upper limit of normal)
   * \>60 years of age and one of the following:

     * diabetes (oral hypoglycemic agent and/or insulin)
     * urgent revascularization (waiting in hospital)
     * LV ejection fraction \<35%
     * current or recent smoker.
   * 55-59 years of age and two of the following:

     * diabetes (oral hypoglycemic agent and/or insulin)
     * urgent revascularization (waiting in hospital)
     * LV ejection fraction \<35%
     * current or recent smoker.

Exclusion Criteria:

Patients will be excluded if they have one of the following:

1. concomitant cardiac procedure associated with CABG,
2. contra-indications to off-pump CABG or on-pump CABG (calcified aorta, intramuscular LAD, calcified coronaries, small target vessels)
3. concomitant life-threatening disease likely to limit life expectancy to less than 2 years,
4. prior enrollment in this trial
5. emergency CABG surgery (immediate revascularization for hemodynamic instability) OR
6. redo CABG.
D: Inclusion Criteria:

* Cardiac surgical patients in whom the use of cardiopulmonary bypass was planned
* Written informed consent of patient
* Age \> 18 years
* And having at least one ore more of the following risk factors for postoperative AKI:

  * Age =/\> 70 years
  * Preoperative plasma creatinine \>120 µmol/L, New York Heart Association class III/IV or LVEF \<35%
  * Insulin dependent diabetes mellitus
  * Valve surgery (with or without coronary artery bypass graft)
  * Redo cardiac surgery

Exclusion Criteria:

* An emergency operation is indicated (within 24 hours after hospital admission or on intra-aortic balloon pump)
* Pregnancy is confirmed or breastfeeding is present
* A renal allograft is present
* Preoperative acute renal failure within 6 weeks (acute rise in serum creatinine \> 50% from baseline) is present
* Pre-operative end stage renal disease (serum creatinine \> 300 µmol/L) is present
* Chronic moderate to high dose corticosteroid therapy (\>10 mg/d prednisone or equivalent) is present
* Known Allergy to Atorvastatin

Answer: C