TrialPanorama/Dataset huggingface dataset:
Please select the outcome measures that correspond to the clinical trial below.
Title: PRONTO: Obstetric and Neonatal Emergency Training Program: A Cluster-Randomized Trial to Measure Impact
Brief Summary: Rates and causes of maternal mortality in Mexico have dropped only slightly; thus, reaching the internationally established Millennium Development Milestones (MDM) is still a distant goal. A fundamental part of reducing maternal and infant mortality is ensuring an adequate and timely response to obstetric emergencies. PRONTO2: Obstetric and Neonatal Emergency Training Program is an innovative training strategy based on simulations designed to train hospital personnel to respond to obstetric emergencies. The objective of this study is to implement PRONTO2 in selected hospitals to measure the effectiveness of the intervention in influencing key behaviors in hospital practices, as well as measuring maternal and neonatal outcomes in intervention versus control hospitals.


Options:
A: Perinatal mortality (12 months)
B: Knowledge test by written test as multiple-choice questions (MCQ). (The participants will get a knowledge test at the training day they will participate in. Ten training days will be conducted in a 3 months period)
C: institutional twenty-four hour newborn mortality rate (1 day); institutional intrapartum stillbirth rate (1 day)
D: The primary outcome was the proportion of deliveries at greater than or equal to 20 weeks gestation in which one or more adverse maternal and/or neonatal outcomes occurred (Adverse Outcome Index).

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: PRONTO: Obstetric and Neonatal Emergency Training Program: A Cluster-Randomized Trial to Measure Impact
Brief Summary: Rates and causes of maternal mortality in Mexico have dropped only slightly; thus, reaching the internationally established Millennium Development Milestones (MDM) is still a distant goal. A fundamental part of reducing maternal and infant mortality is ensuring an adequate and timely response to obstetric emergencies. PRONTO2: Obstetric and Neonatal Emergency Training Program is an innovative training strategy based on simulations designed to train hospital personnel to respond to obstetric emergencies. The objective of this study is to implement PRONTO2 in selected hospitals to measure the effectiveness of the intervention in influencing key behaviors in hospital practices, as well as measuring maternal and neonatal outcomes in intervention versus control hospitals.


Options:
A: increase the proportion of institutional deliveries in intervention vs. control clusters (Up to 15 months)
B: Composite of either >28 week / >1000 gram stillbirth or 7 day neonatal mortality rate (7 days post delivery)
C: Neonatal mortality (7 days)
D: Perinatal mortality (12 months)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: PRONTO: Obstetric and Neonatal Emergency Training Program: A Cluster-Randomized Trial to Measure Impact
Brief Summary: Rates and causes of maternal mortality in Mexico have dropped only slightly; thus, reaching the internationally established Millennium Development Milestones (MDM) is still a distant goal. A fundamental part of reducing maternal and infant mortality is ensuring an adequate and timely response to obstetric emergencies. PRONTO2: Obstetric and Neonatal Emergency Training Program is an innovative training strategy based on simulations designed to train hospital personnel to respond to obstetric emergencies. The objective of this study is to implement PRONTO2 in selected hospitals to measure the effectiveness of the intervention in influencing key behaviors in hospital practices, as well as measuring maternal and neonatal outcomes in intervention versus control hospitals.


Options:
A: Perinatal Mortality (Perinatal mortality data collected at 6 weeks post-delivery. Comparison will include the pre-intervention period of 12 months and the post-intervention period of 12 months.)
B: mortality (day 28)
C: Neonatal mortality (7 days)
D: Perinatal mortality (12 months)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Randomized Clinical Trial to Improve Colon Cancer Screening in Poor Rural Iowa Counties
Brief Summary: The goal of the study is to conduct a randomized clinical trial to test several office-based strategies for improving colon cancer screening among individuals who are regular patients at 16 family practice physician offices in the state of Iowa. These offices are members of the Iowa Research Network (IRENE), a rural practice-based research network. The interventions to be tested are increasing in intensity from the usual care provided in the office, to physician chart reminders, mailed educational materials to patients, a fecal immunochemical test with postage-paid return envelope, and a telephone call designed to determine attitudes and barriers to screening, and to motivate subjects to get screened. Our main research questions are: 1)do attitudes toward CRC screening change after providing educational materials about CRC screening? 2)do mailed educational materials and a FIT, with or without a telephone reminder, result in increased rates of CRC testing with the FIT?


Options:
A: Phase 1: patient who've received interventions based on evidence proportion informed by the indicators (9 months); Phase 2: increase of prescription of evidence based treatment in clinical practice (6 months)
B: colorectal cancer screening (15 months)
C: Episiotomies; Oxytocin use in third stage of labor
D: Cervical spine radiography ordering proportions (12 months)

Answer: B
Please select the outcome measures that correspond to the clinical trial below.
Title: Randomized Clinical Trial to Improve Colon Cancer Screening in Poor Rural Iowa Counties
Brief Summary: The goal of the study is to conduct a randomized clinical trial to test several office-based strategies for improving colon cancer screening among individuals who are regular patients at 16 family practice physician offices in the state of Iowa. These offices are members of the Iowa Research Network (IRENE), a rural practice-based research network. The interventions to be tested are increasing in intensity from the usual care provided in the office, to physician chart reminders, mailed educational materials to patients, a fecal immunochemical test with postage-paid return envelope, and a telephone call designed to determine attitudes and barriers to screening, and to motivate subjects to get screened. Our main research questions are: 1)do attitudes toward CRC screening change after providing educational materials about CRC screening? 2)do mailed educational materials and a FIT, with or without a telephone reminder, result in increased rates of CRC testing with the FIT?


Options:
A: The primary outcome is improvement in the overall composite of all metrics eligible for intervention regardless of their selection as targets. (12 months)
B: Resolution or improvement in screened chronic condition; Improved communication with primary care doctor; Improved patient satisfaction; Improved physician satisfaction
C: The following dependant variables were measured in this study;; Diabetes medical error in the 12 months post-intervention, Glycated hemoglobin (A1c) values and A1c test rates in the 12 months post-intervention, and; LDL-cholesterol levels and test rates in the 12 months post-intervention.
D: colorectal cancer screening (15 months)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Randomized Clinical Trial to Improve Colon Cancer Screening in Poor Rural Iowa Counties
Brief Summary: The goal of the study is to conduct a randomized clinical trial to test several office-based strategies for improving colon cancer screening among individuals who are regular patients at 16 family practice physician offices in the state of Iowa. These offices are members of the Iowa Research Network (IRENE), a rural practice-based research network. The interventions to be tested are increasing in intensity from the usual care provided in the office, to physician chart reminders, mailed educational materials to patients, a fecal immunochemical test with postage-paid return envelope, and a telephone call designed to determine attitudes and barriers to screening, and to motivate subjects to get screened. Our main research questions are: 1)do attitudes toward CRC screening change after providing educational materials about CRC screening? 2)do mailed educational materials and a FIT, with or without a telephone reminder, result in increased rates of CRC testing with the FIT?


Options:
A: Cardiac Medication Use (3 and 12 months)
B: The primary outcome is the proportion of patients starting prescription osteoporosis treatment within 3 months of fracture recognition (3 months)
C: colorectal cancer screening (15 months)
D: Compliance rates with care guidelines (12 months)

Answer: C
Please select the outcome measures that correspond to the clinical trial below.
Title: Medium Term Health Coaching and Life-long Monitoring in Cardiovascular Disease in Norrbotten
Brief Summary: The purpose of this study is to evaluate whether the introduction of large-scale personalized and technology supported telemonitoring and health coaching interventions produces benefits in terms of health related quality of life, health status and empowerment of patients with a cardiovascular disease. In addition, the trials evaluate the economical and organizational impact of the new services and examine their acceptability by patients and health professionals.


Options:
A: Death or non-fatal myocardial infarction (Up to 10 months)
B: Change in HbA1c (12 Months)
C: HbA1c; Muscular strength
D: SF-36 (12 months follow-up)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Contingency Management for Persons With Severe Mental Illness
Brief Summary: Contingency management is efficacious for treating cocaine abuse, but contingency management interventions have rarely been applied to patients with severe and persistent mental health problems. This pilot project will estimate effect sizes of contingency management for reducing cocaine use in patients receiving psychiatric care at a large community based mental health program. In total, 30 cocaine abusing patients will be randomized to one of two 8-week treatment conditions: standard care or standard care with contingency management. Patients in both conditions will provide breath and urine samples for toxicology testing twice per week. In the contingency management condition, patients will receive the opportunity to win prizes for submitting cocaine negative urine samples. The investigators expect that patients receiving contingency management will evidence reductions in cocaine use and may show improvements in psychiatric symptoms and psychosocial functioning relative to patients in standard care. Effect size estimates obtained from this study will be used to guide larger scale and longer duration evaluations of contingency management for dually diagnosed patients.


Options:
A: reduction in drug use (8 weeks)
B: Addiction Severity Index Alcohol Composite (Baseline, end of treatment (month 3), 3-month post-treatment follow-up); Addiction Severity Index Drug Composite (Baseline, end of treatment (3 months), and 3-month post-treatment followup); Brief Addiction Monitor (Baseline, end of treatment (month 3), 3-month post-treatment follow-up)
C: Relapse (Through hospitalization completion, an average of 14 days); Relapse (Through the 8-week period of arm 1 or 2.); Relapse (At 1 month follow-up after Arm 1 or 2); Relapse (At 3 months follow-up after Arm 1 or 2); Relapse (At 6 months follow-up after Arm 1 or 2); Treatment retention (Through hospitalization completion, an average of 14 days); Treatment retention (Through the 8-week period of arm 1 or 2); Treatment retention (At 1 month follow-up after completing Arm 1 or 2); Treatment retention (At 3 months follow-up after completing Arm 1 or 2); Treatment retention (At 6 months follow-up after completing Arm 1 or 2)
D: longest continuous period of cocaine abstinence (Week 8)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Contingency Management for Persons With Severe Mental Illness
Brief Summary: Contingency management is efficacious for treating cocaine abuse, but contingency management interventions have rarely been applied to patients with severe and persistent mental health problems. This pilot project will estimate effect sizes of contingency management for reducing cocaine use in patients receiving psychiatric care at a large community based mental health program. In total, 30 cocaine abusing patients will be randomized to one of two 8-week treatment conditions: standard care or standard care with contingency management. Patients in both conditions will provide breath and urine samples for toxicology testing twice per week. In the contingency management condition, patients will receive the opportunity to win prizes for submitting cocaine negative urine samples. The investigators expect that patients receiving contingency management will evidence reductions in cocaine use and may show improvements in psychiatric symptoms and psychosocial functioning relative to patients in standard care. Effect size estimates obtained from this study will be used to guide larger scale and longer duration evaluations of contingency management for dually diagnosed patients.


Options:
A: longest continuous period of cocaine abstinence (Week 8)
B: abused drug abstinence measured by observed urine specimen testing weeks 1-52, and bimonthly months 13-18
C: Non-concordant unprotected anal intercourse (Baseline, 6, 12, 18, 24 weeks)
D: Stimulant drug use as measured by urine analysis (Treatment phase: 12 weeks (3 measurements a week), Follow Up Phase: 3 months (1 measuresment a month))

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: Contingency Management for Persons With Severe Mental Illness
Brief Summary: Contingency management is efficacious for treating cocaine abuse, but contingency management interventions have rarely been applied to patients with severe and persistent mental health problems. This pilot project will estimate effect sizes of contingency management for reducing cocaine use in patients receiving psychiatric care at a large community based mental health program. In total, 30 cocaine abusing patients will be randomized to one of two 8-week treatment conditions: standard care or standard care with contingency management. Patients in both conditions will provide breath and urine samples for toxicology testing twice per week. In the contingency management condition, patients will receive the opportunity to win prizes for submitting cocaine negative urine samples. The investigators expect that patients receiving contingency management will evidence reductions in cocaine use and may show improvements in psychiatric symptoms and psychosocial functioning relative to patients in standard care. Effect size estimates obtained from this study will be used to guide larger scale and longer duration evaluations of contingency management for dually diagnosed patients.


Options:
A: Health of Nations Outcome Scale (HONOS) (Baseline, 6 months, 12 months, 18 months,)
B: Cannabis use reduction in the follow-up (Baseline, 16 weeks (posttreatment), at 3 and 6 months and at one year of follow up.); Improvement in the development of psychotic disorder (Baseline, 16 weeks (posttreatment), at 3 and 6 months and at one year of follow up); Changes in the components of the endogenous cannabinoid system (Baseline, 16 weeks (posttreatment), at 3 and 6 months and at one year of follow up); Normalizing the possible alterations in the endogenous cannabinoid system (Baseline, 16 weeks (posttreatment), at 3 and 6 months and at one year of follow up)
C: longest continuous period of cocaine abstinence (Week 8)
D: Cognitive/Affective Functional Outcomes (Baseline, 6-month, 12-month and 18 month)

Answer: C
Please select the outcome measures that correspond to the clinical trial below.
Title: Effects of Bariatric Surgery in Swedish Obese Subjects
Brief Summary: The purpose of the Swedish Obese Subjects (SOS) study is to examine the long-term effects of bariatric surgery on overall mortality and obesity-related co-morbidities.


Options:
A: Overall mortality (10 years)
B: BMIZ-score evolution in 2 years. (2 years)
C: Body Mass Index (kg/m2) (2 years after treatment initiation)
D: growth disorders (18 years); obesity (18 years)

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: Randomised, Double-blind, Parallel-group, Placebo-controlled, Fixed-dose Study of [Azilect®] Rasagiline in Levodopa-treated Parkinson's Patients With Motor Fluctuations in China
Brief Summary: The rationale for conducting this study is to evaluate the efficacy, tolerability, and safety of rasagiline compared to placebo in levodopa-treated Parkinson's Disease (PD) Chinese patients with motor fluctuations. Azilect® (Rasagiline) is indicated for the treatment of idiopathic PD as monotherapy (without levodopa) or as adjunct therapy (with levodopa) in patients with end of dose fluctuations.


Options:
A: Change From Baseline in Mean Total Daily OFF Time Using Parkinson's Disease Patient Diary (Baseline and Weeks 4, 8, 12, and 16)
B: Change of Berg Balance Scale (BBS) (15 minutes/session; measured at weeks 0, 6, and 12 of the experiment)
C: 306A Efficacy: Change in Orthostatic Hypotension Questionnaire Score (OHQ) (Baseline, Week 8); 306B Efficacy: Change in Dizziness/Lightheadedness/Feeling Faint/Feeling Like You Might Black Out (OHSA Item 1) (Baseline, Week1)
D: Number of Participants With Treatment-Emergent Adverse Events [Safety & Tolerability] (8 weeks)

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: Intra-abdominal at Cesarean Section: A Randomized Controlled Trial
Brief Summary: The purpose of this study is to determine if intra-abdominal irrigation at the time of cesarean delivery increased maternal GI discomfort without affecting infection rates.

We hypothesized that avoiding intra-operative irrigation at the time of cesarean delivery will decrease intra-operative nausea and vomiting without increasing maternal infectious morbidity, post-operative pain, return of bowel function, or time to discharge.


Options:
A: Drainage volume (7 days)
B: Post-operative infection (6 weeks)
C: N/A
D: Intra-operative nausea (intra-operative)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Intra-abdominal at Cesarean Section: A Randomized Controlled Trial
Brief Summary: The purpose of this study is to determine if intra-abdominal irrigation at the time of cesarean delivery increased maternal GI discomfort without affecting infection rates.

We hypothesized that avoiding intra-operative irrigation at the time of cesarean delivery will decrease intra-operative nausea and vomiting without increasing maternal infectious morbidity, post-operative pain, return of bowel function, or time to discharge.


Options:
A: Incidence of Nausea and Vomiting (intraoperative 2-3 hours); Incidence of Nausea and Vomiting (2 hrs postoperative); Incidence of Nausea and Vomiting (24hrs postoperative)
B: Incidence of Post-operative Nausea and/or Vomiting (48 hours)
C: Occurrence of Intra-operative and Post-operative Vomiting (During surgery (1 hour) and thru 72 hours after surgery)
D: Intra-operative nausea (intra-operative)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Effect of Sugammadex Compared With Usual Care for Reversal of Neuromuscular Blockade Induced by Rocuronium on Incidence of Residual Blockade at PACU Entry
Brief Summary: This study will compare the incidence of residual neuromuscular blockade in participants who undergo reversal of neuromuscular blockade with sugammadex compared to those who undergo reversal of neuromuscular blockade with usual care (neostigmine/glycopyrrolate).


Options:
A: Incidence of Residual Neuromuscular Blockade (NMB) as Defined by a Train-of-Four (TOF) Ratio <0.9 at Post Anesthesia Care Unit (PACU) Entry (At PACU entry on Day 1)
B: Percentage of Participants With Delirium Using the CAM Over Time (Baseline, hospital interviews, weeks 2, 4 and 6)
C: The incidence of explicit recall of events during the surgical and anesthetic periods. (Three years)
D: The initial day and number of days there is a significant change from baseline in the mean Delirium Observation Screening (DOS) score, and/or delirium is diagnosed according to the DSM-IV criteria. (Assessed within 1 to 7 days after initiation of the study intervention.)

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: COMPARATIVE STUDY OF DIAGNOSTIC VALUE FOR THE ECHOTIP® PROCORE™ 22 Gauge NEEDLE VERSUS ECHOTIP® 22 Gauge IN THE DIAGNOSIS OF PANCREATIC SOLID TUMORS UNDER ENDOSCOPIC ULTRASONOGRAPHY : THE "PICORE" STUDY
Brief Summary: The negative predictive value of fine needle aspiration under ultrasound endoscopy (EUS) for the diagnostic of solid pancreatic masses is 70% on average in the current literature with 22 gauge needles. There is a wide variability of this rate across studies (from 38 to 92%). In case of negativity of the biopsy, the risk of missing a pancreatic cancer whose prognosis is severe and extensive treatment, remains important. To improve the sensitivity of EUS echo endoscopy, several methods were used. A new needle (Echo Tip ® HD ProCore ™) has received CE Mark in the field of EUS. This instrument combines the comfortable and handy size of 22 Gauge and innovative design (window lateralized bevel) with in vitro studies obtaining core biopsy. In addition, a single pass through the tumor is achieved with this hand against several (2-3 minimum) with the current hardware. The theoretical goal is to have a tissue material more abundant during the sampling, without increasing morbidity and increase the diagnostic accuracy. A preliminary prospective study with this material has shown interesting results (increase the diagnostic accuracy of 15%).

To determine the diagnostic gain with this new hand, it seemed essential to propose a prospective comparative study (22 gauge needle ProCore ™ versus the old EchoTip ® 22-Gauge) randomized (randomization of the order of the needles) in crossover (on the same lesion) in samples of pancreatic solid tumors. The caliber of 22 gauge is the gauge most often used for punctures under ultrasound endoscopy, resulting in less morbidity. Puncture by the 2 needles on the same injury can limit the effect of variability between patients and thereby have a better power for the investigators study without increasing the risk of complications (the needle ProCore ™ does not require that one pass through the tumor). The study of pancreatic solid tumors is one that poses the biggest diagnostic problem still present in the investigators daily practice. The aim of this study is to compare the diagnostic accuracy of the needle ProCore™ versus EchoTip® in etiological cyto histological diagnostic for pancreatic solid tumors under EUS.


Options:
A: Assess the yield of combination modalities in the diagnosis of pancreatic cysts using EUS/FNA, Fiber optics (direct visualization probe), and prototype needle based confocal laser-induced endomicroscopy miniprobe (nCLE) (From the date of imaging until follow up for 6 months to two years.)
B: Value of endoscopic ultrasound elastography for the differential diagnoses of pancreatic masses. (18 months)
C: Diagnostic accuracy of fine needle aspiration Echo Tip® HD ProCore™ versus EchoTip® in the etiological cyto histological in pancreatic solid tumors explored under endoscopy ultrasonography. (6 months)
D: number of passes (up to 12 months)

Answer: C