Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: First Prospective Intergroup Translational Research Trial Assessing the Potential Predictive Value of p53 Using a Functional Assay in Yeast in Patients With Locally Advanced/Inflammatory or Large Operable Breast Cancer Prospectively Randomised to a Taxane Versus a Non Taxane Regimen
Brief Summary: RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Currently patients with breast cancer are treated with one of several very similar combinations of drugs. Analysis of biomarkers in tumor tissue may help doctors predict how well patients with breast cancer will respond to treatment and help doctors choose the best drug regimen to treat each patient.

PURPOSE: This randomized phase III trial is studying giving different regimens of chemotherapy and comparing how well they work in treating women with large operable or locally advanced or inflammatory breast cancer. This study is also looking at whether analyzing a specific biomarker (p53) in tumor tissue may help doctors predict how well patients will respond to treatment and help doctors choose the best drug to treat each patient.


Options:
A: Arm Label: BIBW 2992; Type: EXPERIMENTAL; Interventions: Drug: BIBW 2992 | Arm Label: Cisplatin/Pemetrexed; Type: ACTIVE_COMPARATOR; Interventions: Drug: Pemetrexed, Drug: Cisplatin | Intervention Type: DRUG; Name: Pemetrexed; Assigned to Arm(s): Cisplatin/Pemetrexed | Intervention Type: DRUG; Name: BIBW 2992; Assigned to Arm(s): BIBW 2992 | Intervention Type: DRUG; Name: Cisplatin; Assigned to Arm(s): Cisplatin/Pemetrexed
B: Intervention Type: DRUG; Name: Abacavir; Assigned to Arm(s): N/A
C: Arm Label: PGx-treatment; Type: EXPERIMENTAL; Interventions: Drug: Isoniazid | Arm Label: STD-treatment; Type: ACTIVE_COMPARATOR; Interventions: Drug: isoniazed | Intervention Type: DRUG; Name: Isoniazid; Assigned to Arm(s): PGx-treatment | Intervention Type: DRUG; Name: isoniazed; Assigned to Arm(s): STD-treatment
D: Arm Label: non taxane based chemotherapy; Type: ACTIVE_COMPARATOR; Interventions: Biological: filgrastim, Drug: cyclophosphamide, Drug: epirubicin hydrochloride, Drug: fluorouracil, Genetic: microarray analysis, Other: immunohistochemistry staining method, Other: laboratory biomarker analysis, Procedure: biopsy, Procedure: conventional surgery, Procedure: neoadjuvant therapy, Radiation: radiation therapy | Arm Label: taxane based chemotherapy; Type: EXPERIMENTAL; Interventions: Drug: docetaxel, Drug: epirubicin hydrochloride, Genetic: microarray analysis, Other: immunohistochemistry staining method, Other: laboratory biomarker analysis, Procedure: biopsy, Procedure: conventional surgery, Procedure: neoadjuvant therapy, Radiation: radiation therapy | Intervention Type: BIOLOGICAL; Name: filgrastim; Assigned to Arm(s): non taxane based chemotherapy | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): non taxane based chemotherapy | Intervention Type: DRUG; Name: docetaxel; Assigned to Arm(s): taxane based chemotherapy | Intervention Type: DRUG; Name: epirubicin hydrochloride; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy | Intervention Type: DRUG; Name: fluorouracil; Assigned to Arm(s): non taxane based chemotherapy | Intervention Type: GENETIC; Name: microarray analysis; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy | Intervention Type: OTHER; Name: immunohistochemistry staining method; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy | Intervention Type: OTHER; Name: laboratory biomarker analysis; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy | Intervention Type: PROCEDURE; Name: biopsy; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy | Intervention Type: PROCEDURE; Name: neoadjuvant therapy; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): non taxane based chemotherapy, taxane based chemotherapy

Answer: D