Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Neuroblastoma Study Phase II Study of Various Therapies in Patients With Neuroblastoma
Brief Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill tumor cells. Combining these therapies may kill more tumor cells.

PURPOSE: Phase II trial to study the effectiveness of combining chemotherapy and radiation therapy with or without peripheral stem cell transplantation in treating patients who have neuroblastoma.


Options:
A: Arm Label: R0: COJEC plus G-CSF; Type: EXPERIMENTAL; Interventions: Drug: Carboplatin, Drug: Etoposide, Drug: Cisplatin, Drug: Cyclophosphamide, Drug: G-CSF | Arm Label: R0: COJEC; Type: ACTIVE_COMPARATOR; Interventions: Drug: Vincristine, Drug: Carboplatin, Drug: Etoposide, Drug: Cisplatin, Drug: Cyclophosphamide | Arm Label: R1: BuMel MAT; Type: ACTIVE_COMPARATOR; Interventions: Drug: Busulfan, Drug: Melphalan | Arm Label: R1: CEM MAT; Type: EXPERIMENTAL; Interventions: Drug: Carboplatin, Drug: Etoposide, Drug: Melphalan | Arm Label: R2: ch14.18/CHO; Type: ACTIVE_COMPARATOR; Interventions: Drug: ch14.18/CHO | Arm Label: R2: ch14.18/CHO plus Aldesleukin; Type: EXPERIMENTAL; Interventions: Drug: Aldesleukin, Drug: ch14.18/CHO | Arm Label: R3: COJEC Induction; Type: ACTIVE_COMPARATOR; Interventions: Drug: Vincristine, Drug: Carboplatin, Drug: Etoposide, Drug: Cisplatin, Drug: Cyclophosphamide | Arm Label: R3: Modified N7; Type: EXPERIMENTAL; Interventions: Drug: Vincristine, Drug: Etoposide, Drug: Cisplatin, Drug: Cyclophosphamide, Drug: Doxorubicin | Arm Label: R4: cnt inf ch14.18/CHO; Type: ACTIVE_COMPARATOR; Interventions: Drug: ch14.18/CHO | Arm Label: R4: cnt inf ch14.18/CHO plus Aldesleukin; Type: EXPERIMENTAL; Interventions: Drug: Aldesleukin, Drug: ch14.18/CHO | Intervention Type: DRUG; Name: Vincristine; Assigned to Arm(s): R0: COJEC, R3: COJEC Induction, R3: Modified N7 | Intervention Type: DRUG; Name: Aldesleukin; Assigned to Arm(s): R2: ch14.18/CHO plus Aldesleukin, R4: cnt inf ch14.18/CHO plus Aldesleukin | Intervention Type: DRUG; Name: ch14.18/CHO; Assigned to Arm(s): R2: ch14.18/CHO, R2: ch14.18/CHO plus Aldesleukin, R4: cnt inf ch14.18/CHO, R4: cnt inf ch14.18/CHO plus Aldesleukin | Intervention Type: DRUG; Name: Carboplatin; Assigned to Arm(s): R0: COJEC, R0: COJEC plus G-CSF, R1: CEM MAT, R3: COJEC Induction | Intervention Type: DRUG; Name: Etoposide; Assigned to Arm(s): R0: COJEC, R0: COJEC plus G-CSF, R1: CEM MAT, R3: COJEC Induction, R3: Modified N7 | Intervention Type: DRUG; Name: Cisplatin; Assigned to Arm(s): R0: COJEC, R0: COJEC plus G-CSF, R3: COJEC Induction, R3: Modified N7 | Intervention Type: DRUG; Name: Cyclophosphamide; Assigned to Arm(s): R0: COJEC, R0: COJEC plus G-CSF, R3: COJEC Induction, R3: Modified N7 | Intervention Type: DRUG; Name: Doxorubicin; Assigned to Arm(s): R3: Modified N7 | Intervention Type: DRUG; Name: G-CSF; Assigned to Arm(s): R0: COJEC plus G-CSF | Intervention Type: DRUG; Name: Busulfan; Assigned to Arm(s): R1: BuMel MAT | Intervention Type: DRUG; Name: Melphalan; Assigned to Arm(s): R1: BuMel MAT, R1: CEM MAT
B: Intervention Type: BIOLOGICAL; Name: filgrastim; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: carboplatin; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: cisplatin; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: dacarbazine; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: etoposide; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: ifosfamide; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: melphalan; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: tretinoin; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: vincristine sulfate; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: vindesine; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: autologous bone marrow transplantation; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: peripheral blood stem cell transplantation; Assigned to Arm(s): N/A | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): N/A
C: Arm Label: Arm I (unpurged PBSC collection); Type: EXPERIMENTAL; Interventions: Biological: filgrastim, Drug: carboplatin, Drug: cisplatin, Drug: cyclophosphamide, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: isotretinoin, Drug: melphalan, Drug: topotecan hydrochloride, Drug: vincristine sulfate, Procedure: autologous bone marrow transplantation, Procedure: bone marrow ablation with stem cell support, Procedure: conventional surgery, Procedure: peripheral blood stem cell transplantation, Radiation: radiation therapy | Arm Label: Arm II (unpurged PBSC collection); Type: EXPERIMENTAL; Interventions: Drug: carboplatin, Drug: cisplatin, Drug: cyclophosphamide, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: isotretinoin, Drug: melphalan, Drug: topotecan hydrochloride, Drug: vincristine sulfate, Procedure: autologous bone marrow transplantation, Procedure: bone marrow ablation with stem cell support, Procedure: conventional surgery, Procedure: peripheral blood stem cell transplantation, Radiation: radiation therapy | Intervention Type: BIOLOGICAL; Name: filgrastim; Assigned to Arm(s): Arm I (unpurged PBSC collection) | Intervention Type: DRUG; Name: carboplatin; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: cisplatin; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: etoposide; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: isotretinoin; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: melphalan; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: topotecan hydrochloride; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: vincristine sulfate; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: PROCEDURE; Name: autologous bone marrow transplantation; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: PROCEDURE; Name: bone marrow ablation with stem cell support; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: PROCEDURE; Name: peripheral blood stem cell transplantation; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection)
D: Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: vincristine sulfate; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): N/A

Answer: B