Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: PeRioperative OXygen Fraction - Effect on Surgical Site Infection and Pulmonary Complications After Abdominal Surgery (The PROXI-trial)
Brief Summary: Aim: To investigate the effect of high intra- and postoperative oxygen concentration (80%, as opposed to normally 30%) on surgical wound infection and pulmonary complications after abdominal surgery.

Background: Surgical wound infection is a common and serious complication. Tissue oxygen tension is often low after surgery and the resistance against infection depends on this factor through bacterial killing by neutrophils. Oxygen is a substrate in this reaction, and it is hypothesized that by increasing the arterial oxygen tension, the risk of surgical wound infection is reduced. Previous studies to test this hypothesis have shown entirely different results. Hence, the clinical decision between high and normal oxygen concentration is still controversial.

Primary hypothesis of study: Use of 80% oxygen decreases the incidence of surgical wound infection after abdominal surgery.

Secondary objectives: To investigate the effect 80% oxygen on pulmonary complications (atelectasis, pneumonia, respiratory insufficiency), second operation, mortality and length of postoperative hospitalization and admission to intensive care unit after abdominal surgery.


Options:
A: Arm Label: High-normal PaO2; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oxygen | Arm Label: Low-normal PaO2; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oxygen | Intervention Type: DRUG; Name: Oxygen; Assigned to Arm(s): High-normal PaO2, Low-normal PaO2
B: Arm Label: Low normal MAP and low normal PaO2; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal MAP, Other: Low normal PaO2. | Arm Label: High normal MAP and low normal PaO2; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal MAP, Other: Low normal PaO2. | Arm Label: Low normal MAP and high normal PaO2; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal MAP, Other: High normal PaO2 | Arm Label: High normal MAP and high normal PaO2; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal MAP, Other: Low normal PaO2. | Intervention Type: OTHER; Name: Low normal MAP; Assigned to Arm(s): Low normal MAP and high normal PaO2, Low normal MAP and low normal PaO2 | Intervention Type: OTHER; Name: High normal MAP; Assigned to Arm(s): High normal MAP and high normal PaO2, High normal MAP and low normal PaO2 | Intervention Type: OTHER; Name: Low normal PaO2.; Assigned to Arm(s): High normal MAP and high normal PaO2, High normal MAP and low normal PaO2, Low normal MAP and low normal PaO2 | Intervention Type: OTHER; Name: High normal PaO2; Assigned to Arm(s): Low normal MAP and high normal PaO2
C: Arm Label: A; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oxygen | Arm Label: B; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oxygen | Intervention Type: DRUG; Name: Oxygen; Assigned to Arm(s): A, B
D: Arm Label: Lower SpO2 Target; Type: ACTIVE_COMPARATOR; Interventions: Other: Lower SpO2 Target | Arm Label: Intermediate SpO2 Target; Type: ACTIVE_COMPARATOR; Interventions: Other: Intermediate SpO2 Target | Arm Label: Higher SpO2 Target; Type: ACTIVE_COMPARATOR; Interventions: Other: Higher SpO2 Target | Intervention Type: OTHER; Name: Lower SpO2 Target; Assigned to Arm(s): Lower SpO2 Target | Intervention Type: OTHER; Name: Intermediate SpO2 Target; Assigned to Arm(s): Intermediate SpO2 Target | Intervention Type: OTHER; Name: Higher SpO2 Target; Assigned to Arm(s): Higher SpO2 Target

Answer: C