Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A 12 Week Study to Evaluate the Effect of Fluticasone Furoate (FF, GW685698)/Vilanterol (VI, GW642444) 100/25 mcg Inhalation Powder Delivered Once Daily Via a Novel Dry Powder Inhaler (NDPI) on Arterial Stiffness Compared With Tiotropium Bromide 18 mcg Delivered Once Daily Via a HandiHaler in Subjects With Chronic Obstructive Pulmonary Disease (COPD).
Brief Summary: This study is designed to evaluate the effect of fluticasone furoate (FF, GW685698)/vilanterol (VI, GW642444) Inhalation Powder once daily (QD) on arterial stiffness compared with Tiotropium QD over 12 week treatment period in subjects with COPD and aortic pulse wave velocity (aPWV) \> 12.0 m/s at Visit 1. Arterial stiffness will be measured as aPWV. This is a comparator, randomised, double-blind, double-dummy, parallel group, multi-centre study. Subjects who meet the eligibility criteria at Screening and meet the randomization criteria at the end of a 2-week Run-In period will enter a 12-week treatment period. There will be an approximate 7-day Follow-up period after the treatment period.


Options:
A: Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo to tiotropium + olodaterol | Arm Label: tiotropium + olodaterol high dose with BM; Type: EXPERIMENTAL; Interventions: Drug: tiotropium +olodaterol | Arm Label: tiotropium; Type: ACTIVE_COMPARATOR; Interventions: Drug: tiotropium | Arm Label: tiotropium + olodaterol with exercise training and BM; Type: EXPERIMENTAL; Interventions: Drug: tiotropium+olodaterol | Intervention Type: DRUG; Name: placebo to tiotropium + olodaterol; Assigned to Arm(s): placebo | Intervention Type: DRUG; Name: tiotropium+olodaterol; Assigned to Arm(s): tiotropium + olodaterol with exercise training and BM | Intervention Type: DRUG; Name: tiotropium +olodaterol; Assigned to Arm(s): tiotropium + olodaterol high dose with BM | Intervention Type: DRUG; Name: tiotropium; Assigned to Arm(s): tiotropium
B: Arm Label: Relovair; Type: EXPERIMENTAL; Interventions: Drug: fluticasone furoate (FF, GW685698)/vilanterol (VI, GW642444) 100/25 mcg Novel Dry Powder Inhaler (NDPI) | Arm Label: Tiotropium; Type: ACTIVE_COMPARATOR; Interventions: Drug: Tiotropium | Intervention Type: DRUG; Name: fluticasone furoate (FF, GW685698)/vilanterol (VI, GW642444) 100/25 mcg Novel Dry Powder Inhaler (NDPI); Assigned to Arm(s): Relovair | Intervention Type: DRUG; Name: Tiotropium; Assigned to Arm(s): Tiotropium
C: Arm Label: Glyco 25; Type: EXPERIMENTAL; Interventions: Drug: Glycopyrrolate | Arm Label: Glyco 50; Type: EXPERIMENTAL; Interventions: Drug: Glycopyrrolate | Arm Label: Glyco 100; Type: EXPERIMENTAL; Interventions: Drug: Glycopyrrolate | Arm Label: BDP/FF 400/24; Type: ACTIVE_COMPARATOR; Interventions: Drug: Comparator | Intervention Type: DRUG; Name: Glycopyrrolate; Assigned to Arm(s): Glyco 25 | Intervention Type: DRUG; Name: Glycopyrrolate; Assigned to Arm(s): Glyco 50 | Intervention Type: DRUG; Name: Glycopyrrolate; Assigned to Arm(s): Glyco 100 | Intervention Type: DRUG; Name: Comparator; Assigned to Arm(s): BDP/FF 400/24
D: Arm Label: GFF MDI; Type: EXPERIMENTAL; Interventions: Drug: GFF MDI | Arm Label: GP MDI; Type: EXPERIMENTAL; Interventions: Drug: GP MDI | Arm Label: FF MDI; Type: EXPERIMENTAL; Interventions: Drug: FF MDI | Arm Label: Open-label tiotropium bromide inhalation powder; Type: ACTIVE_COMPARATOR; Interventions: Drug: Open-label tiotropium bromide inhalation powder (Spiriva® Handihaler®) | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo MDI | Intervention Type: DRUG; Name: GFF MDI; Assigned to Arm(s): GFF MDI | Intervention Type: DRUG; Name: GP MDI; Assigned to Arm(s): GP MDI | Intervention Type: DRUG; Name: FF MDI; Assigned to Arm(s): FF MDI | Intervention Type: DRUG; Name: Open-label tiotropium bromide inhalation powder (Spiriva® Handihaler®); Assigned to Arm(s): Open-label tiotropium bromide inhalation powder | Intervention Type: DRUG; Name: Placebo MDI; Assigned to Arm(s): Placebo

Answer: B