Please select the eligibility criteria that correspond to the clinical trial below.
Title: High and Low Carbohydrate Weight Loss Approaches to Type 2 Diabetes Mellitus (The Diabetes Dietary Study (DDS))
Brief Summary: The purpose of this study is to determine the effects of a low-carbohydrate diet compared to a low-fat/high-carbohydrate diet on glucose control in patients who have Type 2 Diabetes.


Options:
A: Inclusion Criteria:

* Diagnosis of type 2 diabetes
* HbA1c 7-10%
* BMI (kg/m2) \> 25 and \< 40 and weight \< 280 lb.
* Skill at and willingness to perform capillary blood glucose self-monitoring ---Insulin (changed to long-acting basal during run-in) or sulfonylurea treatment

Exclusion Criteria:

* Age \> 65
* Weight \>280 lb
* Health conditions that may interfere with study participation or for which the study interventions may be contraindicated. These include: kidney stones or kidney disease (creatinine \> 1.3 and 1.5 mg/dL for females and males, respectively; proteinuria \> 300 ug/g creatinine); liver or gall bladder disease; significant heart disease (myocardial infarction in the past six months, prior or current evidence of congestive heart failure, other evidence of left ventricular (LV) dysfunction) or other indices of active cardiac abnormalities, (angina, electrocardiogram evidence of ischemia or transmural myocardial infarction), significant anemia; and cancer (other than effectively treated non melanomatous skin cancer and surgically treated cervical cancer in situ).
* Current hypokalemia defined as serum potassium levels \<3.5 mg/dL.
* Osteoporosis
* Type 1 diabetes (history of ketoacidosis or undetectable fasting C-peptide levels)
* History of severe or repeated hypoglycemia, or hypoglycemia unawareness. Lack of recourse to another person in the immediate vicinity in the unlikely event that they require outside assistance for severe hypoglycemia.
* Triglyceride levels \> 400 mg/dL.
* Inability or unwillingness to comply with any aspects of the dietary and research protocol.
* Weight changes \> 10 lbs in the past three months.
* History of binge eating disorder or other eating disorders.
* Pregnancy or intention to become pregnant in the next 12 months.
* Current oral hypoglycemic medication that raises the blood insulin level
B: Inclusion Criteria:

* Age 18 to 35 years
* Body mass index (BMI) ≥ 30 kg/m2
* Access to a working telephone
* Conversant in English
* Written medical clearance from a primary care physician or nurse practitioner, ruling out any pre-existing or complicating medical condition

Exclusion Criteria:

* Body weight \>300 lbs
* Major medical illness (heart, kidney or liver disease; diabetes; cancer; endocrinopathy; psychiatric illness) or other active medical problem
* An obesity-associated genetic syndrome (e.g., Prader-Willi)
* An abnormal screening laboratory test (ALT, creatinine, BUN, hematocrit)
* Fasting blood glucose ≥ 126 mg/dl)
* Taking any prescription medication that affects body weight (glucocorticoids, neuropsychiatric agents), blood pressure, or serum cholesterol concentrations
* Currently smoking (1 cigarette during any of the last 7 days)
* Previous diagnosis of an eating disorder (anorexia nervosa, bulimia, binge-eating disorder)
* If female, not pregnant or planning to become pregnant in the next 18 months and not lactating
* Failure to complete the pre-enrollment visits
C: Inclusion Criteria:

* Age: 18-80 years old.
* Body mass index between 27.5 - 40.
* Steady weight in last 3 months (±3 kg).
* Informed consent provided.

Exclusion Criteria:

* Presence of uncontrolled endocrinological pathology (including hypothyroidism).
* Type 2 diabetes mellitus with bad metabolic control (HbA1c \> 8%).
* Lipid-lowering drugs in the last 3 months.
* Intake of functional foods with plant sterols in the past 6 weeks.
* Vitamin supplements intake.
* Hormone replacement therapy.
* Consumption of Orlistat in the last 2 months
* High intake of alcohol (\> 30 gr./day).
* Any serious disease which involves less than 1 year life expectancy or, in investigators judgment, limit the follow-up of an homogeneous diet throughout the study.
* Pregnancy or intention of pregnancy during the study.
D: Inclusion Criteria:

* BMI\>27
* age\>40
* History of CHD or diabetes in any age or BMI level

Exclusion Criteria:

* Pregnant or lactating women.
* Active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.
* Serum creatinine \> 3 mg/dl.
* Liver dysfunction ( ³ 2 fold level of ALT and AST enzymes).
* Participation in another trial in which active intervention is being received.
* Any intestinal problem that would prevent the patient from eating one of the test diets (for example, gastric stapling that might prevent consumption of vegetables).

Answer: A