Please select the eligibility criteria that correspond to the clinical trial below.
Title: A RENEW Intervention for Elderly Cancer Survivors
Brief Summary: RATIONALE: Exercise may help improve mobility and relieve fatigue and/or weakness in cancer survivors. It is not yet known whether exercise is more effective than standard therapy in improving mobility and reducing fatigue and/or weakness in older cancer survivors.

PURPOSE: This randomized clinical trial is studying exercise to see how well it works compared to standard therapy in improving mobility and reducing fatigue and/or weakness in older cancer survivors.


Options:
A: Inclusion Criteria:

* histologically confirmed breast cancer.
* mentally competent.
* physician approval to participate in the study.
* free from chronic medical and orthopaedic conditions.
* no current or planned pregnancy.
* ability to read and understand English.
* must be in the post treatment phase of their cancer trajectory.
* willing to accept random assignment.
* not currently participating in another QoL intervention.
* no known or active metastatic disease.
B: Inclusion Criteria:

* Female
* Age 21-75
* Diagnosed with a primary breast cancer Stage 0-IIIa
* Current tamoxifen or aromatase inhibitor use is allowed
* At least 3 months post treatment (e.g., surgery, chemotherapy, or radiation therapy)
* BMI: 24 kg/m2 or greater (If Asian or Asian-American BMI: 23 kg/m2 or greater)
* No contraindications to participating in a yoga program
* Able to come for clinic visits, and attend weekly classes, and fill out questionnaires and logs in English
* Gives informed consent, agrees to be randomly assigned

Exclusion Criteria:

* Plans to leave the study area within the follow-up period
* Is pregnant or plans to become pregnant during the study period.
* History of myocardial infarction (heart attack) or stroke in the previous 6 months, or diabetes (current diagnosis)
* Has practiced yoga more than 1 time per month in the past six months.
* Current use of medications likely to interfere with adherence to interventions or study outcomes
* Alcohol or drug abuse, significant mental illness (as assessed by study staff impression)
C: DISEASE CHARACTERISTICS:

* Survivor of breast, prostate, colon, lung, lymphoma, ovarian, bladder, or esophageal cancer with no evidence of disease
* At least moderate levels of fatigue and/or weakness
* Impaired mobility but ambulatory and medically able to participate in an exercise regimen

  * No impaired knee flexion, defined as \< 90º

PATIENT CHARACTERISTICS:

* Folstein Mini-Mental Status Examination score ≥ 23
* No extreme claustrophobia
* No diagnosed chronic fatigue syndrome/disorder
* No neurological impairments, including the following:

  * Central nervous system disorder (e.g., multiple sclerosis or Parkinson's disease)
  * Neurological insult (cerebrovascular attack) that manifests in a mobility disorder
* No myopathic disease (e.g., focal myopathy) that effects skeletal muscle structure/function
* No rheumatological disease that has an effect on muscle and/or mobility (e.g., polymyalgia rheumatica)

PRIOR CONCURRENT THERAPY:

* More than 6 months since prior regular aerobic or resistance exercise

  * Regular exercise defined as 2-3 times per week
* At least 6 months since prior cancer treatment (surgery, radiation, and/or chemotherapy )
* No concurrent cancer-related treatment other than hormonal therapy
D: Inclusion Criteria:

* Female 18 y and over,
* Diagnosed with invasive breast cancer (Stage I-III) within two years of enrolment and no evidence, or clinical suspicion, of metastatic disease,
* Post-surgery and had no surgery planned for the next six months at least,
* Had fully completed adjuvant therapy (radiotherapy and/or chemotherapy) not including hormonal therapy,
* No previous malignancy except in the case of ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS), basal cell carcinoma or cervical carcinoma in situ, or where the patient has been disease-free for 10 years,
* No concomitant medical or psychiatric problems that might prevent completion of treatment or follow-up,
* Willing to be randomised, and willing to maintain contact with the investigators over the six months

Exclusion Criteria:

* No evidence of invasive breast cancer (i.e. only pre-invasive disease identified),
* Previous invasive breast cancer (surgically treated DCIS or LCIS is allowed),
* Inability to participate in PA because of severe disability (e.g. severe arthritic conditions), psychiatric illness and vulnerable subjects, such as pregnant women.
* Any other patient where PA was not approved by their oncologist due to the presence of one or more contraindications to exercise in cancer patients.

Answer: C