Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Physicians' Health Study II: Trial of Vitamins in the Chemoprevention of Cancer, CVD, and Eye Disease
Brief Summary: The use of vitamin E, vitamin C, beta carotene, and/or multivitamins may keep cancer, cardiovascular disease, eye diseases, or cognitive decline from occurring. This randomized clinical trial studied vitamin E, vitamin C, beta carotene, and/or multivitamins to see how well they work compared with placebos in preventing cancer, cardiovascular disease, eye disease, and cognitive decline in male doctors aged 50 years and older.


Options:
A: Arm Label: Arm 1; Type: EXPERIMENTAL; Interventions: Drug: dl-alpha-tocopherol | Arm Label: Arm 2; Type: EXPERIMENTAL; Interventions: Drug: Memantine | Arm Label: Arm 3; Type: EXPERIMENTAL; Interventions: Drug: dl-alpha-tocopherol, Drug: Memantine | Arm Label: Arm 4; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: dl-alpha-tocopherol; Assigned to Arm(s): Arm 1 | Intervention Type: DRUG; Name: Memantine; Assigned to Arm(s): Arm 2 | Intervention Type: DRUG; Name: dl-alpha-tocopherol; Assigned to Arm(s): Arm 3 | Intervention Type: DRUG; Name: Memantine; Assigned to Arm(s): Arm 3 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Arm 4
B: Arm Label: Folic acid (400mcg) + Vitamin B12 (100 mcg); Type: EXPERIMENTAL; Interventions: Drug: Folate (400mcg) and Vitamin B12 (100 mcg) | Arm Label: Mediated physical activity promotion; Type: EXPERIMENTAL; Interventions: Behavioral: mediated physical activity promotion | Arm Label: Mental health literacy; Type: EXPERIMENTAL; Interventions: Behavioral: Mental health literacy | Arm Label: Placebo tablet; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo | Arm Label: Nutrition information; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Nutrition information | Arm Label: Pain and arthritis management information; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: pain and arthritis management information | Intervention Type: DRUG; Name: Folate (400mcg) and Vitamin B12 (100 mcg); Assigned to Arm(s): Folic acid (400mcg) + Vitamin B12 (100 mcg) | Intervention Type: BEHAVIORAL; Name: mediated physical activity promotion; Assigned to Arm(s): Mediated physical activity promotion | Intervention Type: BEHAVIORAL; Name: Mental health literacy; Assigned to Arm(s): Mental health literacy | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Placebo tablet | Intervention Type: BEHAVIORAL; Name: Nutrition information; Assigned to Arm(s): Nutrition information | Intervention Type: BEHAVIORAL; Name: pain and arthritis management information; Assigned to Arm(s): Pain and arthritis management information
C: Arm Label: vitamin supplements; Type: EXPERIMENTAL; Interventions: Drug: Folic Acid, Drug: Vitamin B6, Drug: Vitamin B12 | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo | Intervention Type: DRUG; Name: Folic Acid; Assigned to Arm(s): vitamin supplements | Intervention Type: DRUG; Name: Vitamin B6; Assigned to Arm(s): vitamin supplements | Intervention Type: DRUG; Name: Vitamin B12; Assigned to Arm(s): vitamin supplements | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Placebo
D: Arm Label: Vitamin E; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Vitamin E | Arm Label: Vitamin C; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Vitamin C | Arm Label: Multivitamin; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Multivitamin | Arm Label: Beta-carotene; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Beta-carotene | Intervention Type: DIETARY_SUPPLEMENT; Name: Vitamin E; Assigned to Arm(s): Vitamin E | Intervention Type: DIETARY_SUPPLEMENT; Name: Vitamin C; Assigned to Arm(s): Vitamin C | Intervention Type: DIETARY_SUPPLEMENT; Name: Multivitamin; Assigned to Arm(s): Multivitamin | Intervention Type: DIETARY_SUPPLEMENT; Name: Beta-carotene; Assigned to Arm(s): Beta-carotene

Answer: D