Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Improving Outcome Measures For Physiotherapy Trials of Airway Clearance in Adults With Cystic Fibrosis
Brief Summary: This is a randomised controlled cross-over trial involving adult cystic fibrosis (CF) patients from the Royal Brompton Hospital, London investigating outcome measures used in airway clearance trials.

Each participant will attend the research facility for two visits. Participants will be randomly assigned to the order that they perform the study sessions. Visit A will involve a period of rest for up to 60 minutes in-between assessments; Visit B will involve a session of airway clearance (ACT) utilising ACBT supervised by a specialist physiotherapist in adult CF.

Participants will perform the outcome measure (OM) tests of impulse oscillation system (IOS), lung clearance index (LCI), and spirometry, then either rest (visit A) or perform a supervised ACBT session (visit B) using electronic impedance tomography (EIT) during the session. IOS, LCI and spirometry will be repeated after the session. Sputum will be collected throughout the ACT or rest sessions and for 30 minutes after each of these sessions is completed. Questionnaires asking patient views on the OMs will be completed at the end of each study visit.

Analysis will be based upon differences in outcome measures and in-between study days.


Options:
A: Arm Label: Usual Airway Clearance Technique; Type: ACTIVE_COMPARATOR; Interventions: Other: Usual airway clearance | Arm Label: High Frequency Chest Wall Oscillation (HFCWO); Type: EXPERIMENTAL; Interventions: Device: High Frequency Chest Wall Oscillation (HFCWO) | Intervention Type: DEVICE; Name: High Frequency Chest Wall Oscillation (HFCWO); Assigned to Arm(s): High Frequency Chest Wall Oscillation (HFCWO) | Intervention Type: OTHER; Name: Usual airway clearance; Assigned to Arm(s): Usual Airway Clearance Technique
B: Arm Label: A; Type: ACTIVE_COMPARATOR; Interventions: Other: Positive Expiratory Pressure (PEP) | Arm Label: B; Type: ACTIVE_COMPARATOR; Interventions: Other: High Frequency Chest Wall Oscillation (HFCWO) using InCourage Vest System | Intervention Type: OTHER; Name: Positive Expiratory Pressure (PEP); Assigned to Arm(s): A | Intervention Type: OTHER; Name: High Frequency Chest Wall Oscillation (HFCWO) using InCourage Vest System; Assigned to Arm(s): B
C: Arm Label: USUAL CARE; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: INHALATION WITH PEP DEVICE; Type: ACTIVE_COMPARATOR; Interventions: Device: INHALATION WITH PEP DEVICE (Acapella Duet) | Intervention Type: DEVICE; Name: INHALATION WITH PEP DEVICE (Acapella Duet); Assigned to Arm(s): INHALATION WITH PEP DEVICE
D: Arm Label: Visit A; Type: ACTIVE_COMPARATOR; Interventions: Other: Rest period | Arm Label: Visit B; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Airway clearance session using the Active Cycle of Breathing Techniques (ACBT) | Intervention Type: PROCEDURE; Name: Airway clearance session using the Active Cycle of Breathing Techniques (ACBT); Assigned to Arm(s): Visit B | Intervention Type: OTHER; Name: Rest period; Assigned to Arm(s): Visit A

Answer: D