Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Phase I Placebo-Controlled Study of the Infectivity, Safety and Immunogenicity of a Single Dose of a Recombinant Live-attenuated Respiratory Syncytial Virus Vaccine, LID cp ΔM2-2, Lot RSV#009B, Delivered as Nose Drops to RSV-Seronegative Infants and Children 6 to 24 Months of Age
Brief Summary: The purpose of this study is to evaluate the safety, infectivity, and immunogenicity of a single dose of a recombinant live-attenuated respiratory syncytial virus (RSV) vaccine in RSV-seronegative infants and children 6 to 24 months of age.

This study is a companion study to IMPAACT 2012.


Options:
A: Arm Label: 1 and 2 - Adults; Type: EXPERIMENTAL; Interventions: Biological: rHPIV1 84/del170/942A, Lot PIV1 #104A vaccine | Arm Label: 3A - Seropositive Children; Type: EXPERIMENTAL; Interventions: Biological: rHPIV1 84/del170/942A, Lot PIV1 #104A vaccine | Arm Label: 3B - Seropositive Children; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Arm Label: 4A - Seronegative Infants and Children; Type: EXPERIMENTAL; Interventions: Biological: rHPIV1 84/del170/942A, Lot PIV1 #104A vaccine | Arm Label: 4B - Seronegative Infants and Children; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Arm Label: 5A - Seronegative Infants and Children; Type: EXPERIMENTAL; Interventions: Biological: rHPIV1 84/del170/942A, Lot PIV1 #104A vaccine | Arm Label: 5B - Seronegative Infants and Children; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Intervention Type: BIOLOGICAL; Name: rHPIV1 84/del170/942A, Lot PIV1 #104A vaccine; Assigned to Arm(s): 1 and 2 - Adults, 3A - Seropositive Children, 4A - Seronegative Infants and Children, 5A - Seronegative Infants and Children | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): 3B - Seropositive Children, 4B - Seronegative Infants and Children, 5B - Seronegative Infants and Children
B: Arm Label: RSV LID cp ΔM2-2 Vaccine; Type: EXPERIMENTAL; Interventions: Biological: RSV LID cp ΔM2-2 Vaccine | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Intervention Type: BIOLOGICAL; Name: RSV LID cp ΔM2-2 Vaccine; Assigned to Arm(s): RSV LID cp ΔM2-2 Vaccine | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: Group 1: RSV vaccine; Type: EXPERIMENTAL; Interventions: Biological: RSV ΔNS2 Δ1313 I1314L Vaccine | Arm Label: Group 1: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Arm Label: Group 2: RSV vaccine; Type: EXPERIMENTAL; Interventions: Biological: RSV ΔNS2 Δ1313 I1314L Vaccine | Arm Label: Group 2: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Arm Label: Group 3: RSV vaccine; Type: EXPERIMENTAL; Interventions: Biological: RSV ΔNS2 Δ1313 I1314L Vaccine | Arm Label: Group 3: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Arm Label: Group 4: RSV vaccine; Type: EXPERIMENTAL; Interventions: Biological: RSV ΔNS2 Δ1313 I1314L Vaccine | Arm Label: Group 4: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Intervention Type: BIOLOGICAL; Name: RSV ΔNS2 Δ1313 I1314L Vaccine; Assigned to Arm(s): Group 1: RSV vaccine, Group 2: RSV vaccine, Group 3: RSV vaccine, Group 4: RSV vaccine | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Group 1: Placebo, Group 2: Placebo, Group 3: Placebo, Group 4: Placebo
D: Arm Label: GSK3389245A_LD GROUP; Type: EXPERIMENTAL; Interventions: Biological: GSK3389245A_LD GROUP | Arm Label: GSK3389245A_HD GROUP; Type: EXPERIMENTAL; Interventions: Biological: GSK3389245A_HD GROUP | Arm Label: Bexsero Group; Type: ACTIVE_COMPARATOR; Interventions: Biological: Bexsero | Arm Label: Placebo Group; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: BIOLOGICAL; Name: GSK3389245A_LD GROUP; Assigned to Arm(s): GSK3389245A_LD GROUP | Intervention Type: BIOLOGICAL; Name: GSK3389245A_HD GROUP; Assigned to Arm(s): GSK3389245A_HD GROUP | Intervention Type: BIOLOGICAL; Name: Bexsero; Assigned to Arm(s): Bexsero Group | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo Group

Answer: B