Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Korean Multicenter, Randomized, Double-Blind, Clinical Trial to Evaluate the Efficacy and Tolerability of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting in the First Cycle of Moderately Emetogenic Chemotherapies (MEC, Non-AC Regimes) With Broad Range of Tumor Types (KMEC Study)
Brief Summary: This is an efficacy and safety study to compare aprepitant with ondansetron for the prevention of nausea and vomiting in the first cycle of moderately emetogenic chemotherapy (MEC) in participants with solid tumors. MECs include a number of commonly used cancer chemotherapeutic drugs including: oxaliplatin-based, irinotecan-based, and carboplatin-based regimens.

The primary hypothesis of this study is that the Aprepitant Regimen is superior to the Control (ondansetron) Regimen with respect to the percentage of participants with No Vomiting Overall (in the 120 hours following initiation of MEC) in participants with solid tumors.


Options:
A: Arm Label: 1; Type: OTHER; Interventions: Drug: aprepitant, Drug: Comparator: ondansetron, Drug: Comparator: dexamethasone, Drug: Comparator; Placebo (unspecified) | Arm Label: 2; Type: OTHER; Interventions: Drug: Comparator: ondansetron, Drug: Comparator: dexamethasone, Drug: Comparator: fosaprepitant dimeglumine, Drug: Comparator; Placebo (unspecified) | Intervention Type: DRUG; Name: aprepitant; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Comparator: ondansetron; Assigned to Arm(s): 1, 2 | Intervention Type: DRUG; Name: Comparator: dexamethasone; Assigned to Arm(s): 1, 2 | Intervention Type: DRUG; Name: Comparator: fosaprepitant dimeglumine; Assigned to Arm(s): 2 | Intervention Type: DRUG; Name: Comparator; Placebo (unspecified); Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Comparator; Placebo (unspecified); Assigned to Arm(s): 2
B: Intervention Type: DRUG; Name: Palonosetron; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: Granisetron; Assigned to Arm(s): N/A
C: Arm Label: Aprepitant Regimen; Type: EXPERIMENTAL; Interventions: Drug: Aprepitant, Drug: Ondansetron, Drug: Dexamethasone, Drug: Ondansetron Placebo, Drug: Rescue Therapy (granisetron, dolasetron, tropisetron or ondansetron; metoclopramide or alizapride). | Arm Label: Control Regimen; Type: ACTIVE_COMPARATOR; Interventions: Drug: Aprepitant Placebo, Drug: Ondansetron, Drug: Dexamethasone, Drug: Rescue Therapy (granisetron, dolasetron, tropisetron or ondansetron; metoclopramide or alizapride). | Intervention Type: DRUG; Name: Aprepitant; Assigned to Arm(s): Aprepitant Regimen | Intervention Type: DRUG; Name: Aprepitant Placebo; Assigned to Arm(s): Control Regimen | Intervention Type: DRUG; Name: Ondansetron; Assigned to Arm(s): Aprepitant Regimen, Control Regimen | Intervention Type: DRUG; Name: Dexamethasone; Assigned to Arm(s): Aprepitant Regimen, Control Regimen | Intervention Type: DRUG; Name: Ondansetron Placebo; Assigned to Arm(s): Aprepitant Regimen | Intervention Type: DRUG; Name: Rescue Therapy (granisetron, dolasetron, tropisetron or ondansetron; metoclopramide or alizapride).; Assigned to Arm(s): Aprepitant Regimen, Control Regimen
D: Arm Label: Control; Type: PLACEBO_COMPARATOR; Interventions: Drug: Dexamethasone, Drug: Placebo, Drug: Ondansetron | Arm Label: Single Dose IV; Type: EXPERIMENTAL; Interventions: Drug: Casopitant, Drug: Dexamethasone, Drug: Ondansetron | Intervention Type: DRUG; Name: Casopitant; Assigned to Arm(s): Single Dose IV | Intervention Type: DRUG; Name: Dexamethasone; Assigned to Arm(s): Control, Single Dose IV | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Control | Intervention Type: DRUG; Name: Ondansetron; Assigned to Arm(s): Control, Single Dose IV

Answer: C