Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Response and Adaptation to Aerobic Exercise in Patients With Pulmonary Hypertension: Initial Studies for Establishing Guidelines
Brief Summary: This study will determine if a rehabilitation exercise program can help people with pulmonary hypertension (PH) increase their physical activity. Patients with PH have an increase in blood pressure in the pulmonary blood vessels (artery, vein or capillaries) that leads to shortness of breath, dizziness, fainting and other symptoms.

Healthy volunteers and people with pulmonary hypertension between 21 and 75 years of age may be eligible for this study.

All participants undergo the following tests and procedures:

* Medical history and physical examination
* 6-minute walk test: Subjects walk as fast as they can for 6 minutes on a walking track to determine their ability to participate in physical activity.
* Questionnaires: Subjects complete nine questionnaires related to their fatigue, daily physical activity, mood, and so forth.
* Maximum treadmill test: The exercise begins at an easy level and gradually increases until the subject says he or she can no longer continue or the investigator decides it is not safe to continue. Subjects are fitted with a mask, electrodes and light sensors to measure how well the heart is working and how well the muscles use oxygen.

Patients with pulmonary hypertension undergo the following additional procedures:

* Activity monitoring: Patients wear a monitor for 3 days that measures movement and heart rate.
* Group assignment: Patients are randomly assigned to Group 1 (education plus aerobic exercise) or Group 2 (education followed by exercise).
* Group 1 patients will attend classes three days a week at either Inova Fairfax Hospital Pulmonary Rehabilitation Center or The National Institutes of Health for 10 weeks. Two sessions a week will include a 1 hour education session as well as a 30-45 minute track or treadmill exercise session. The third session will only include exercise. During the education patients will learn about a healthy lifestyle with pulmonary hypertension. After the 10 weeks of education and exercise, subjects repeat the 6-minute walk test, maximum treadmill test and questionnaires.
* Group 2 patients participate in 2; 1-hour educational session at either the Inova Pulmonary Rehabilitation Center or The National Institutes of Health for 10 weeks. After the classes, they repeat the 6-minute walk test, maximum treadmill test and questionnaires. The following 10 weeks will consist of 3 days a week of 30-45 minute track or treadmill walking at either Inova or NIH, after which they again repeat the questionnaires, treadmill and walk tests.


Options:
A: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Other: Aerobic exercise | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Other: Aerobic exercise | Intervention Type: OTHER; Name: Aerobic exercise; Assigned to Arm(s): 1, 2
B: Arm Label: Patients with PAH; Type: EXPERIMENTAL; Interventions: Other: home cardiac rehabilitation and respiratory rehabilitation | Arm Label: Patients with HFREF; Type: EXPERIMENTAL; Interventions: Other: home cardiac rehabilitation and respiratory rehabilitation | Arm Label: Patients with IHD; Type: EXPERIMENTAL; Interventions: Other: home cardiac rehabilitation and respiratory rehabilitation | Arm Label: Control group; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: OTHER; Name: home cardiac rehabilitation and respiratory rehabilitation; Assigned to Arm(s): Patients with HFREF, Patients with IHD, Patients with PAH
C: Arm Label: Exercise and Respiratory Training; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Exercise and Respiratory Training | Intervention Type: BEHAVIORAL; Name: Exercise and Respiratory Training; Assigned to Arm(s): Exercise and Respiratory Training
D: Arm Label: Placebo group; Type: PLACEBO_COMPARATOR; Interventions: N/A | Arm Label: Exercise Group Galileo PAH; Type: ACTIVE_COMPARATOR; Interventions: Device: Exercise Group Galileo PAH | Intervention Type: DEVICE; Name: Exercise Group Galileo PAH; Assigned to Arm(s): Exercise Group Galileo PAH

Answer: A