Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Double-Blind, Placebo Controlled, Parallel Group Study of Patiromer for the Enablement of Spironolactone Use for Blood Pressure Control in Patients With Resistant Hypertension and Chronic Kidney Disease
Brief Summary: The purpose of this study is to determine if patiromer treatment in chronic kidney disease (CKD) subjects receiving spironolactone for the treatment of resistant hypertension will result in more persistent use of spironolactone through prevention of hyperkalemia and lead to improved blood pressure control compared with treatment with spironolactone alone (placebo).


Options:
A: Arm Label: patiromer; Type: ACTIVE_COMPARATOR; Interventions: Drug: patiromer | Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo | Intervention Type: DRUG; Name: patiromer; Assigned to Arm(s): patiromer | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): placebo
B: Arm Label: Stratum 1: 8.4 g/d patiromer; Type: EXPERIMENTAL; Interventions: Drug: patiromer, Drug: losartan, Drug: spironolactone | Arm Label: Stratum 1: 16.8 g/d patiromer; Type: EXPERIMENTAL; Interventions: Drug: patiromer, Drug: losartan, Drug: spironolactone | Arm Label: Stratum 1: 25.2 g/d patiromer; Type: EXPERIMENTAL; Interventions: Drug: patiromer, Drug: losartan, Drug: spironolactone | Arm Label: Stratum 2: 16.8 g/d patiromer; Type: EXPERIMENTAL; Interventions: Drug: patiromer, Drug: losartan, Drug: spironolactone | Arm Label: Stratum 2: 25.2 g/d patiromer; Type: EXPERIMENTAL; Interventions: Drug: patiromer, Drug: losartan, Drug: spironolactone | Arm Label: Stratum 2: 33.6 g/d patiromer; Type: EXPERIMENTAL; Interventions: Drug: patiromer, Drug: losartan, Drug: spironolactone | Intervention Type: DRUG; Name: patiromer; Assigned to Arm(s): Stratum 1: 8.4 g/d patiromer | Intervention Type: DRUG; Name: patiromer; Assigned to Arm(s): Stratum 2: 16.8 g/d patiromer | Intervention Type: DRUG; Name: patiromer; Assigned to Arm(s): Stratum 1: 16.8 g/d patiromer | Intervention Type: DRUG; Name: patiromer; Assigned to Arm(s): Stratum 1: 25.2 g/d patiromer | Intervention Type: DRUG; Name: patiromer; Assigned to Arm(s): Stratum 2: 25.2 g/d patiromer | Intervention Type: DRUG; Name: patiromer; Assigned to Arm(s): Stratum 2: 33.6 g/d patiromer | Intervention Type: DRUG; Name: losartan; Assigned to Arm(s): Stratum 1: 16.8 g/d patiromer, Stratum 1: 25.2 g/d patiromer, Stratum 1: 8.4 g/d patiromer, Stratum 2: 16.8 g/d patiromer, Stratum 2: 25.2 g/d patiromer, Stratum 2: 33.6 g/d patiromer | Intervention Type: DRUG; Name: spironolactone; Assigned to Arm(s): Stratum 1: 16.8 g/d patiromer, Stratum 1: 25.2 g/d patiromer, Stratum 1: 8.4 g/d patiromer, Stratum 2: 16.8 g/d patiromer, Stratum 2: 25.2 g/d patiromer, Stratum 2: 33.6 g/d patiromer
C: Arm Label: Sodium zirconium cyclosilicate 10 g three times daily; Type: EXPERIMENTAL; Interventions: Drug: Sodium zirconium cyclosilicate | Arm Label: Placebo once daily; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: Sodium zirconium cyclosilicate 5 g once daily; Type: EXPERIMENTAL; Interventions: Drug: Sodium zirconium cyclosilicate | Arm Label: Sodium zirconium cyclosilicate 10 g once daily; Type: EXPERIMENTAL; Interventions: Drug: Sodium zirconium cyclosilicate | Arm Label: Sodium zirconium cyclosilicate 15 g once daily; Type: EXPERIMENTAL; Interventions: Drug: Sodium zirconium cyclosilicate | Intervention Type: DRUG; Name: Sodium zirconium cyclosilicate; Assigned to Arm(s): Sodium zirconium cyclosilicate 10 g once daily, Sodium zirconium cyclosilicate 10 g three times daily, Sodium zirconium cyclosilicate 15 g once daily, Sodium zirconium cyclosilicate 5 g once daily | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo once daily
D: Arm Label: Group 1 - Patiromer; Type: EXPERIMENTAL; Interventions: Drug: Patiromer, Drug: Spironolactone | Arm Label: Group 2 - Placebo; Type: EXPERIMENTAL; Interventions: Drug: Placebo, Drug: Spironolactone | Intervention Type: DRUG; Name: Patiromer; Assigned to Arm(s): Group 1 - Patiromer | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Group 2 - Placebo | Intervention Type: DRUG; Name: Spironolactone; Assigned to Arm(s): Group 1 - Patiromer, Group 2 - Placebo

Answer: D