Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Prostatic Artery Embolization vs. Conventional Transurethral Prostatectomy in the Treatment of Benign Prostatic Hyperplasia: A Prospective Randomized Trial
Brief Summary: Benign prostatic hyperplasia (BPH) is a prevalent entity, affecting over 50% of men older than 60 years. The clinical picture of the disease includes lower urinary tract symptoms such as interrupted and weak urinary stream, nocturia, urgency and leaking and even sexual dysfunction in some individuals. Medical therapy is usually the first-line treatment. However, the efficacy of drugs like alpha-blockers is limited, and as disease progresses more invasive treatment options have to be taken into consideration. In cases with moderate to severe lower urinary tract symptoms (LUTS) transurethral resection of the prostate (TUR-P) is the standard treatment. TURP, however, is limited to prostates smaller than 60-80ml and the procedure is associated with a complication rate. The cumulative short-term morbidity rate is around 11% and the necessity for surgical revision is as high as 6%. Bleeding requiring transfusions and transurethral resection syndrome represent potentially serious threats to elderly and frail patients. Prostatic artery embolization (PAE) has been suggested as a minimal invasive alternative procedure, which can be performed in an outpatient setting with rapid recovery and low morbidity.

The investigators hypothesize that PAE is non-inferior in the treatment of symptomatic BPH compared to conventional and established TUR-P.


Options:
A: Arm Label: UroLift System; Type: ACTIVE_COMPARATOR; Interventions: Device: UroLift System | Arm Label: Cystoscopy; Type: SHAM_COMPARATOR; Interventions: Other: Cystoscopy | Arm Label: Crossover; Type: ACTIVE_COMPARATOR; Interventions: Device: Crossover | Intervention Type: DEVICE; Name: UroLift System; Assigned to Arm(s): UroLift System | Intervention Type: OTHER; Name: Cystoscopy; Assigned to Arm(s): Cystoscopy | Intervention Type: DEVICE; Name: Crossover; Assigned to Arm(s): Crossover
B: Arm Label: UroLift System; Type: ACTIVE_COMPARATOR; Interventions: Device: UroLift System | Arm Label: Transurethral Resection of the Prostate; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Transurethral Resection of the Prostate | Intervention Type: DEVICE; Name: UroLift System; Assigned to Arm(s): UroLift System | Intervention Type: PROCEDURE; Name: Transurethral Resection of the Prostate; Assigned to Arm(s): Transurethral Resection of the Prostate
C: Arm Label: Participants Aged 40 Years or Over; Type: N/A; Interventions: N/A
D: Arm Label: Prostatic artery embolization; Type: EXPERIMENTAL; Interventions: Procedure: Prostatic artery embolization | Arm Label: Conventional monopolar transurethral prostatectomy; Type: OTHER; Interventions: Procedure: monopolar transurethral prostatectomy | Intervention Type: PROCEDURE; Name: Prostatic artery embolization; Assigned to Arm(s): Prostatic artery embolization | Intervention Type: PROCEDURE; Name: monopolar transurethral prostatectomy; Assigned to Arm(s): Conventional monopolar transurethral prostatectomy

Answer: D