Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized Controlled Trial on Weaning Preterm Neonates From Nasal Continuous Positive Airway Pressure
Brief Summary: There is little data published concerning the best approach to nasal continuous positive airway pressure (nCPAP) weaning. Potential complications associated with prolonged nCPAP therapy include gastric distension, nasal trauma,pneumothorax,agitation and nosocomial infection. Moreover, Infants on nCPAP may also require more intensive nursing care and the use of extra equipment. Therefore, minimizing the amount of time that a patient requires CPAP may be beneficial. On the other hand, removing CPAP too early may lead to complications that include: increasing apnea, increased oxygen requirement, increased work of breathing, the need to re-start CPAP, and intubation and mechanical ventilation. Moreover, an experimental study have demonstrated an improvement in lung growth after the prolonged use of CPAP.

Nasal cannula (NC) flows at 1-2 L/min may also generate a positive pressure in the airway of preterm infants. The use of NC flow to generate positive airway pressure would minimize many of the application issues of nCPAP. However, NC systems used in neonates routinely employ gas that is inadequately warmed and humidified, limiting the use of such flows due to increased risk of nasal mucosa injury, and possibly increasing the risk for nosocomial infection.

The purpose of this randomized controlled trial is to evaluate the clinical impact of two methods for weaning preterm infants from nCPAP.


Options:
A: Arm Label: HHFNC; Type: ACTIVE_COMPARATOR; Interventions: Other: Nasal CPAP, Other: Humidified High Flow Nasal Cannula (HHFNC) | Arm Label: nCPAP; Type: ACTIVE_COMPARATOR; Interventions: Other: Nasal CPAP, Other: Humidified High Flow Nasal Cannula (HHFNC) | Intervention Type: OTHER; Name: Nasal CPAP; Assigned to Arm(s): HHFNC, nCPAP | Intervention Type: OTHER; Name: Humidified High Flow Nasal Cannula (HHFNC); Assigned to Arm(s): HHFNC, nCPAP
B: Arm Label: NIMV- nasal respiratory support; Type: EXPERIMENTAL; Interventions: Device: NIMV with SLE ventilator vs HFNC via Vapotherm | Arm Label: HFNC- nasal respiratory support with HFNC; Type: EXPERIMENTAL; Interventions: Device: NIMV with SLE ventilator vs HFNC via Vapotherm | Intervention Type: DEVICE; Name: NIMV with SLE ventilator vs HFNC via Vapotherm; Assigned to Arm(s): HFNC- nasal respiratory support with HFNC, NIMV- nasal respiratory support
C: Arm Label: CPAP group; Type: EXPERIMENTAL; Interventions: Device: CPAP | Arm Label: Nasal Cannula Group; Type: EXPERIMENTAL; Interventions: Device: Nasal Cannula | Intervention Type: DEVICE; Name: CPAP; Assigned to Arm(s): CPAP group | Intervention Type: DEVICE; Name: Nasal Cannula; Assigned to Arm(s): Nasal Cannula Group
D: Arm Label: HFNC; Type: EXPERIMENTAL; Interventions: Device: Respiratory support HFNC, Device: Respiratory support NCPAP | Arm Label: nCPAP; Type: ACTIVE_COMPARATOR; Interventions: Device: Respiratory support HFNC, Device: Respiratory support NCPAP | Intervention Type: DEVICE; Name: Respiratory support HFNC; Assigned to Arm(s): HFNC, nCPAP | Intervention Type: DEVICE; Name: Respiratory support NCPAP; Assigned to Arm(s): HFNC, nCPAP

Answer: C