Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Efficacy, Durability and Safety of Standardized Fecal Microbiota Transplantation in Patients With Moderate to Severe Ulcerative Colitis
Brief Summary: The gut microbiota is considered to constitute a "microbial organ" which has pivotal roles in the intestinal diseases and body's metabolism. Evidence from animal and human studies strongly supports the link between intestinal bacteria and inflammatory bowel diseases (IBD). Dozens of studies reported its efficacy in treatment of severe Clostridium difficile colitis. Preliminary studies using FMT for Ulcerative Colitis (UC), Crohn's diseases, irritable bowel syndrome (IBS) and constipation have also met with some success. This is an initial step into investigating the potential efficacy of standardized fecal bacteriotherapy through mid-gut (at least below duodenal papilla) for UC, the investigators propose to determine the efficiency and safety of FMT in a series of 500 patients with moderate to severe UC (Montreal classification).


Options:
A: Arm Label: Metronidazole+doxycylcine+terbinafine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Metronidazole, Drug: Doxycycline, Drug: Terbinafine | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Metronidazole; Assigned to Arm(s): Metronidazole+doxycylcine+terbinafine | Intervention Type: DRUG; Name: Doxycycline; Assigned to Arm(s): Metronidazole+doxycylcine+terbinafine | Intervention Type: DRUG; Name: Terbinafine; Assigned to Arm(s): Metronidazole+doxycylcine+terbinafine | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
B: Arm Label: Standardized FMT; Type: EXPERIMENTAL; Interventions: Procedure: Standardized FMT | Arm Label: Traditional treatments; Type: EXPERIMENTAL; Interventions: Drug: Traditional treatments | Intervention Type: PROCEDURE; Name: Standardized FMT; Assigned to Arm(s): Standardized FMT | Intervention Type: DRUG; Name: Traditional treatments; Assigned to Arm(s): Traditional treatments
C: Arm Label: co-transplantation of FMT and pectin; Type: EXPERIMENTAL; Interventions: Other: co-transplantation of FMT and pectin | Arm Label: single fecal microbiota transplantation; Type: ACTIVE_COMPARATOR; Interventions: Other: single fecal microbiota transplantation | Arm Label: give pectin 20g/d; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: pure give pectin 20g/d for five days | Intervention Type: OTHER; Name: co-transplantation of FMT and pectin; Assigned to Arm(s): co-transplantation of FMT and pectin | Intervention Type: OTHER; Name: single fecal microbiota transplantation; Assigned to Arm(s): single fecal microbiota transplantation | Intervention Type: DIETARY_SUPPLEMENT; Name: pure give pectin 20g/d for five days; Assigned to Arm(s): give pectin 20g/d
D: Arm Label: Control; Type: SHAM_COMPARATOR; Interventions: Biological: Placebo | Arm Label: Treatment; Type: EXPERIMENTAL; Interventions: Biological: Fecal Microbiota Transplant | Intervention Type: BIOLOGICAL; Name: Fecal Microbiota Transplant; Assigned to Arm(s): Treatment | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Control

Answer: B