Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Double-Blinded, Placebo-Controlled, Phase I/II, Dose-Ranging Study of the Safety, Reactogenicity, and Immunogenicity of Intramuscular Inactivated Influenza A/H7N7 Vaccine in Healthy Adults
Brief Summary: The purpose of this study is to evaluate the safety, any adverse events or side effects, and the body's immune response to an experimental flu vaccine \[Inactivated Influenza A/H7N7 Vaccine\] being given in increasing doses. Researchers will try to find the smallest dose of flu vaccine needed to cause antibody responses against the flu virus in both single and repeat doses. The study will enroll 125 healthy adults ranging in age from 18 to 40 years old. Subjects will be given 2 doses of the vaccine 28 days apart. Study procedures will include obtaining a medical history, physical exam, blood sample collections, and use of patient memory aids. The volunteers will be in the study for about 7 months.


Options:
A: Arm Label: TIV; Type: ACTIVE_COMPARATOR; Interventions: Biological: Fluzone | Arm Label: LAIV; Type: ACTIVE_COMPARATOR; Interventions: Biological: Flumist | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Physiologic saline | Intervention Type: BIOLOGICAL; Name: Fluzone; Assigned to Arm(s): TIV | Intervention Type: BIOLOGICAL; Name: Flumist; Assigned to Arm(s): LAIV | Intervention Type: OTHER; Name: Physiologic saline; Assigned to Arm(s): Placebo
B: Arm Label: Influenza vaccine; Type: EXPERIMENTAL; Interventions: Biological: Inactivated seasonal influenza vaccine (split virus, Vero cell-derived) | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Phosphate buffered saline | Intervention Type: BIOLOGICAL; Name: Inactivated seasonal influenza vaccine (split virus, Vero cell-derived); Assigned to Arm(s): Influenza vaccine | Intervention Type: OTHER; Name: Phosphate buffered saline; Assigned to Arm(s): Placebo
C: Arm Label: pandemic vaccine 1; Type: EXPERIMENTAL; Interventions: Biological: pandemic vaccine 1 | Arm Label: pandemic vaccine 2; Type: EXPERIMENTAL; Interventions: Biological: pandemic vaccine 2 | Arm Label: pandemic vaccine 5; Type: EXPERIMENTAL; Interventions: Biological: pandemic vaccine 5 | Arm Label: pandemic vaccine 6; Type: EXPERIMENTAL; Interventions: Biological: pandemic vaccine 6 | Arm Label: pandemic vaccine 9; Type: EXPERIMENTAL; Interventions: Biological: pandemic vaccine 9 | Arm Label: pandemic vaccine 10; Type: EXPERIMENTAL; Interventions: Biological: pandemic vaccine 10 | Arm Label: pandemic vaccine 11; Type: EXPERIMENTAL; Interventions: Biological: pandmeic vaccine 11 | Arm Label: pandemic vaccine 12; Type: EXPERIMENTAL; Interventions: Biological: pandmeic vaccine 12 | Arm Label: pandemic vaccine 13; Type: EXPERIMENTAL; Interventions: Biological: pandmic vaccine 13 | Arm Label: placebo group 14; Type: PLACEBO_COMPARATOR; Interventions: Biological: placebo group 14 | Intervention Type: BIOLOGICAL; Name: pandemic vaccine 1; Assigned to Arm(s): pandemic vaccine 1 | Intervention Type: BIOLOGICAL; Name: pandemic vaccine 2; Assigned to Arm(s): pandemic vaccine 2 | Intervention Type: BIOLOGICAL; Name: pandemic vaccine 5; Assigned to Arm(s): pandemic vaccine 5 | Intervention Type: BIOLOGICAL; Name: pandemic vaccine 6; Assigned to Arm(s): pandemic vaccine 6 | Intervention Type: BIOLOGICAL; Name: pandemic vaccine 9; Assigned to Arm(s): pandemic vaccine 9 | Intervention Type: BIOLOGICAL; Name: pandemic vaccine 10; Assigned to Arm(s): pandemic vaccine 10 | Intervention Type: BIOLOGICAL; Name: pandmeic vaccine 11; Assigned to Arm(s): pandemic vaccine 11 | Intervention Type: BIOLOGICAL; Name: pandmeic vaccine 12; Assigned to Arm(s): pandemic vaccine 12 | Intervention Type: BIOLOGICAL; Name: pandmic vaccine 13; Assigned to Arm(s): pandemic vaccine 13 | Intervention Type: BIOLOGICAL; Name: placebo group 14; Assigned to Arm(s): placebo group 14
D: Arm Label: 90 mcg of Influenza A/H7N7; Type: EXPERIMENTAL; Interventions: Biological: Influenza A/H7N7 Vaccine | Arm Label: 15 mcg of Influenza A/H7N7; Type: EXPERIMENTAL; Interventions: Biological: Influenza A/H7N7 Vaccine | Arm Label: 7.5 mcg of Influenza A/H7N7; Type: EXPERIMENTAL; Interventions: Biological: Influenza A/H7N7 Vaccine | Arm Label: 45 mcg of Influenza A/H7N7; Type: EXPERIMENTAL; Interventions: Biological: Influenza A/H7N7 Vaccine | Arm Label: Saline placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: BIOLOGICAL; Name: Influenza A/H7N7 Vaccine; Assigned to Arm(s): 15 mcg of Influenza A/H7N7, 45 mcg of Influenza A/H7N7, 7.5 mcg of Influenza A/H7N7, 90 mcg of Influenza A/H7N7 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Saline placebo

Answer: D