Please select the eligibility criteria that correspond to the clinical trial below.
Title: Fortified Rice for School Children in Cambodia: Effects on Micronutrient Status, Growth, Cognition and Health.
Brief Summary: Rice fortification has been shown to be safe and effective in improving micronutrient status in many studies around the world. However, most studies have been done in Latin America, Africa and India. There are no studies available from Cambodia. Moreover, there is no data available on whether fortified rice can reduce the prevalence of anemia in school children in Cambodia, nor whether there will be additional benefits, such as better learning capability of school children or fewer days missed due to better health. To inform WFP, Cambodian policy and the public on the potential benefits of fortified rice on health and development for Cambodian school children, an intervention study will be conducted in Kampung Speu province during the 2012 - 2013 school year. The study will be conducted by IRD, PATH and WFP. Sixteen schools will be selected to receive either the normal rice provided by the WFP school meal program, or fortified rice instead of normal rice. Three (3) different types of fortified rice will be tested, to identify the best type of fortified rice. In addition, 4 schools with no school meal program will be selected to serve as control. School attendance and morbidity will be followed in all children in the participating schools over the whole school year. Biochemical indicators of micronutrient status will be determined in a subgroup of children (25% of the children), which requires collection of blood, urine and stool samples.


Options:
A: Inclusion Criteria:

* Children, aged 8-12 years, both sexes, attending the local primary schools
* No known or reported history of significant chronic illness
* Free of acute illness and febrile and gastrointestinal problems

Exclusion Criteria:

* Children with severe vitamin A deficiency with a clinical sign of Bioit's spot or ocular signs of xerophthalmia will be excluded
* Children who have serum retinol \< 0.7 umol/L
B: Inclusion Criteria:

* signed informed consent by parent / caretaker
* age between 6 and 14 yrs
* visiting selected school
* taking part in school meal program

Exclusion Criteria:

* any chronic illness affecting growth (such as HIV)
* no informed consent
* severe anemia which will require direct treatment
C: Inclusion Criteria:

* Apparently healthy school going children
* not severely malnourished weight-for-height z-score ≥-2 not severely anemic (Hb\<8g/dl)
* Age: 7-10 years
* Not taking any food supplements/fortified drinks
* Not planning to move out during the study duration

Exclusion Criteria:

* Age: \<7 and \>10 years
* Severe anemia (Hb \< 8 g/dl)
* Severely malnourished children with weight-for-height z-score \<-3 will be excluded.
* Cardiovascular disease on clinical examination or history
* Underlying respiratory disease with impairment of lung function
* Physical disability which can interfere or limit performance of tests
* Recent history (3 months prior) of serious infections, injuries and/ or surgeries
* Any food allergy or food intolerance
* Participation in any nutritional study in the last 1year
* Children consuming nutritional supplements and/ or health food drinks
D: Inclusion Criteria:

* Signed informed consent from at least one guardian
* Ages 5.50 months to 6.49 months
* Availability during the period of the study
* Permanent resident of the area

Exclusion Criteria:

* WHZ \< -2.0 z-scores or presence of oedema
* History of peanut allergy
* Severe illness warranting hospital referral
* Concurrent participation of the child in another clinical trial with intervention to the child

Answer: B