Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: N/A
Brief Summary: Lumbosacral radiculopathy is one of the leading of cause of disability in the U.S. and worldwide. Among recent reviews evaluating epidural steroid injections, some 1 but not all 2 concluded them to be effective in the long-term. In our own double-blind, placebo-controlled study evaluating epidural etanercept, the results showed significant benefit in favor of the etanercept group, but no subject was included with a duration of pain \> 9 months, and the results of this study have yet to be replicated.

Currently, epidural steroid injections are the most frequently performed procedures in pain clinics across the U.S. However, epidural steroids may benefit only a select group of patients. The literature on treating sciatica is notable for a lack of randomized comparative studies involving various treatments. The objective of this project is to conduct a 3-arm study to determine the efficacy of 1) transforaminal epidural corticosteroids; and 2) transforaminal epidural etanercept, in patients with lumbosacral radiculopathy.


Options:
A: Arm Label: DXM 4 mg; Type: EXPERIMENTAL; Interventions: Procedure: Lumbar Transforaminal Epidural Steroid Injection | Arm Label: DXM 8 mg; Type: EXPERIMENTAL; Interventions: Procedure: Lumbar Transforaminal Epidural Steroid Injection | Arm Label: DXM 12 mg; Type: EXPERIMENTAL; Interventions: Procedure: Lumbar Transforaminal Epidural Steroid Injection | Intervention Type: PROCEDURE; Name: Lumbar Transforaminal Epidural Steroid Injection; Assigned to Arm(s): DXM 12 mg, DXM 4 mg, DXM 8 mg
B: Arm Label: Group I; Type: OTHER; Interventions: Procedure: Lumbar Interlaminar Epidural, Procedure: Lumbar Interlaminar Epidural injection | Arm Label: Group II; Type: OTHER; Interventions: Procedure: Lumbar Interlaminar Epidural, Procedure: Lumbar Interlaminar Epidural injection | Intervention Type: PROCEDURE; Name: Lumbar Interlaminar Epidural; Assigned to Arm(s): Group I, Group II | Intervention Type: PROCEDURE; Name: Lumbar Interlaminar Epidural injection; Assigned to Arm(s): Group I, Group II
C: Arm Label: Epidural Steroid injection; Type: EXPERIMENTAL; Interventions: Procedure: Epidural steroid with local anesthetic injection, Drug: Epidural steroid injection | Arm Label: Epidural local anesthetic injection; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Epidural local anesthetic injection, Drug: Epidural local anesthetic injection | Intervention Type: PROCEDURE; Name: Epidural steroid with local anesthetic injection; Assigned to Arm(s): Epidural Steroid injection | Intervention Type: PROCEDURE; Name: Epidural local anesthetic injection; Assigned to Arm(s): Epidural local anesthetic injection | Intervention Type: DRUG; Name: Epidural steroid injection; Assigned to Arm(s): Epidural Steroid injection | Intervention Type: DRUG; Name: Epidural local anesthetic injection; Assigned to Arm(s): Epidural local anesthetic injection
D: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: etanercept | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Drug: methylprednisolone | Arm Label: 3; Type: PLACEBO_COMPARATOR; Interventions: Drug: normal saline | Intervention Type: DRUG; Name: etanercept; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: methylprednisolone; Assigned to Arm(s): 2 | Intervention Type: DRUG; Name: normal saline; Assigned to Arm(s): 3

Answer: D