Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Safety and Efficacy of Probiotics in Bangladeshi Infants
Brief Summary: Here the investigators propose to preliminarily investigate the safety and effects of probiotics in infants in Bangladesh through a pilot randomized clinical trial. The investigators hypothesize that two probiotics are safe for infants in Bangladesh and may have an effect on biomarkers of gut health and immunity. The specific aims of this pilot are: i) to confirm the safety of administering probiotic strains to infants in low-income countries, ii) to determine the effects of dosing frequency on colonization and persistence of probiotics in the GI tract, iii) to measure markers of intestinal and immune function and microbiota structure.


Options:
A: Arm Label: daily probiotic; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Lactobacillus reuteri DSM 17938, Dietary Supplement: Bifidobacterium longum infantis | Arm Label: weekly probiotic; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Lactobacillus reuteri DSM 17938, Dietary Supplement: Bifidobacterium longum infantis | Arm Label: bi-weekly probiotic; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Lactobacillus reuteri DSM 17938, Dietary Supplement: Bifidobacterium longum infantis | Arm Label: control; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DIETARY_SUPPLEMENT; Name: Lactobacillus reuteri DSM 17938; Assigned to Arm(s): bi-weekly probiotic, daily probiotic, weekly probiotic | Intervention Type: DIETARY_SUPPLEMENT; Name: Bifidobacterium longum infantis; Assigned to Arm(s): bi-weekly probiotic, daily probiotic, weekly probiotic
B: Arm Label: Probiotics; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Probiotics | Arm Label: Probiotics + Dietary counseling; Type: EXPERIMENTAL; Interventions: Behavioral: Dietary counselling and probiotics | Arm Label: Dietary counseling + placebo; Type: EXPERIMENTAL; Interventions: Behavioral: Dietary counselling and placebo | Arm Label: Prebiotics; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Prebiotics | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo capsules | Arm Label: Control; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: Dietary counselling and placebo; Assigned to Arm(s): Dietary counseling + placebo | Intervention Type: BEHAVIORAL; Name: Dietary counselling and probiotics; Assigned to Arm(s): Probiotics + Dietary counseling | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo capsules; Assigned to Arm(s): Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: Probiotics; Assigned to Arm(s): Probiotics | Intervention Type: DIETARY_SUPPLEMENT; Name: Prebiotics; Assigned to Arm(s): Prebiotics
C: Arm Label: Lactobacillus reuteri; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Lactobacillus reuteri | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: Lactobacillus reuteri; Assigned to Arm(s): Lactobacillus reuteri | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo; Assigned to Arm(s): Placebo
D: Intervention Type: DRUG; Name: Mixture of probiotic bacteria and prebiotic oligosaccharide; Assigned to Arm(s): N/A

Answer: A