Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Health Effects After Anthracycline and Radiation Therapy (HEART): Dexrazoxane and Prevention of Anthracycline-Related Cardiomyopathy
Brief Summary: This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment. Studying samples of blood in the laboratory from patients receiving dexrazoxane hydrochloride may help doctors learn more about the effects of dexrazoxane hydrochloride on cells. It may also help doctors understand how well patients respond to treatment.


Options:
A: Arm Label: Ancillary-Correlative (laboratory biomarker analysis); Type: N/A; Interventions: Other: Assessment of Therapy Complications, Other: Laboratory Biomarker Analysis, Other: Quality-of-Life Assessment, Other: Questionnaire Administration | Intervention Type: OTHER; Name: Assessment of Therapy Complications; Assigned to Arm(s): Ancillary-Correlative (laboratory biomarker analysis) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Ancillary-Correlative (laboratory biomarker analysis) | Intervention Type: OTHER; Name: Quality-of-Life Assessment; Assigned to Arm(s): Ancillary-Correlative (laboratory biomarker analysis) | Intervention Type: OTHER; Name: Questionnaire Administration; Assigned to Arm(s): Ancillary-Correlative (laboratory biomarker analysis)
B: Arm Label: Cancer survivors; Type: N/A; Interventions: N/A | Arm Label: Sibling Controls; Type: N/A; Interventions: N/A
C: Intervention Type: DRUG; Name: asparaginase (E. Coli); Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: asparaginase (Erwina); Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: dexrazoxane; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: doxorubicin; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: cranial radiation (once daily fractionation); Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: cranial radiation (twice-daily fractionation); Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: Intrathecal chemotherapy without radiation; Assigned to Arm(s): N/A
D: Arm Label: Arm 1; Type: EXPERIMENTAL; Interventions: Biological: bleomycin sulfate, Biological: filgrastim, Drug: cyclophosphamide, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: prednisone, Drug: vincristine sulfate, Radiation: radiation therapy | Arm Label: Arm 2; Type: EXPERIMENTAL; Interventions: Biological: bleomycin sulfate, Biological: filgrastim, Drug: cyclophosphamide, Drug: dexrazoxane hydrochloride, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: prednisone, Drug: vincristine sulfate, Radiation: radiation therapy | Intervention Type: BIOLOGICAL; Name: bleomycin sulfate; Assigned to Arm(s): Arm 1, Arm 2 | Intervention Type: BIOLOGICAL; Name: filgrastim; Assigned to Arm(s): Arm 1, Arm 2 | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): Arm 1, Arm 2 | Intervention Type: DRUG; Name: dexrazoxane hydrochloride; Assigned to Arm(s): Arm 2 | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): Arm 1, Arm 2 | Intervention Type: DRUG; Name: etoposide; Assigned to Arm(s): Arm 1, Arm 2 | Intervention Type: DRUG; Name: prednisone; Assigned to Arm(s): Arm 1, Arm 2 | Intervention Type: DRUG; Name: vincristine sulfate; Assigned to Arm(s): Arm 1, Arm 2 | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): Arm 1, Arm 2

Answer: A