Please select the eligibility criteria that correspond to the clinical trial below.
Title: RAPID: Reducing Pain; Preventing Depression
Brief Summary: The primary question addressed by this prevention study is to explore if improving pain and disability reduces episodes of Major Depression among seniors with knee osteoarthritis (OA) and mild depressive symptoms.


Options:
A: Inclusion Criteria:

* Had unilateral or bilateral knee OA
* Knee OA K\&L grade ≥ 2
* VAS = 3 cm over the previous 24 hours
* Able to walk ≥ 6-meter distances with or without an aid

Exclusion Criteria:

* Had knee or lower limb surgery
* Oral corticosteroid use (current\\ 4 weeks)
* Altered sensation around knee and shoulder
* Exhibited cognitive difficulties
* Intra-articular corticosteroid or hyaluronic acid injection within 6 months
* Had leg sciatica
* Contraindication to manual therapy
B: Inclusion Criteria:

* Knee pain on most days
* Either isolated patellofemoral osteoarthritis or mixed patellofemoral and tibiofemoral osteoarthritis, as based on x-ray

Exclusion Criteria:

* Bed- or chair-bound, usually uses an ambulation aid to walk (e.g., cane, crutch, or walker), or uses a wheelchair
* Pain emanating more from the back or hip than from the knee, as determined by screening questionnaire
* Low pain score on the visual analog scale (VAS) (less than 4 out of 10)
* Plans to move from the area within 10 months of study screening
* Symptomatic comorbid disease that limits activities more than knee pain does, as determined by screening questionnaire (e.g., congestive heart failure, chronic obstructive pulmonary disease)
* Receiving corticosteroid injections in the month before study entry, or receiving hyaluronan in the 6-month period before study entry. No other treatments will result in exclusion, although for patients taking glucosamine and/or chondroitin and/or a non-steroidal anti-inflammatory drug (NSAID), they must have taken these treatments for at least 2 months before study entry and must commit to not start a new treatment during the study.
* Bilateral total knee replacements or plans for a total knee replacement of the affected knee in the next 6 months
* Morbidly obese (body mass index greater than 35), as brace fitting and prevention of slippage of the brace will be difficult
* Known other causes of arthritis, including rheumatoid arthritis, systemic lupus erythematosus, gout, psoriatic arthritis, and pseudogout
* Skin breakdown at the site where the brace will be applied
* Failure to pass the run-in test, or the brace falls down the leg during the run-in
C: Inclusion Criteria:

* 40 years of age or older
* Meet the American College of Rheumatology (ACR) clinical criteria for a diagnosis of knee OA. The ACR clinical criteria for knee OA includes knee pain plus 3 of the following 6 criteria:
* age \> 50 years,
* morning stiffness of \< 30 minutes,
* crepitus on active movement,
* tenderness of the bony margins of the joint,
* bony enlargement of the joint noted on exam,
* lack of palpable warmth of the synovium. Based on this criteria, a subject who is less than 50 years but has knee pain and 3 of the other 5 criteria would also be classified as having knee OA.

Exclusion Criteria:

* do not meet the ACR clinical criteria for knee OA,
* are scheduled for total knee arthroplasty (TKA) surgery,
* have undergone TJA surgery on any lower extremity joint,
* exhibit uncontrolled hypertension (i.e. individuals not currently taking medication for hypertension whose systolic blood pressure is greater than 140 mm Hg or diastolic blood pressure greater than 90 mm Hg at rest),
* have complaints of low back pain or other lower extremity joint pain that affects function at the time of recruitment,
* have a history of neurological disorders that would affect lower extremity function (stroke, peripheral neuropathy, parkinson's disease, multiple sclerosis, etc.),
* are women who are pregnant.
D: Inclusion Criteria:

1. \>/= age 60
2. meets accepted clinical criteria for knee OA based on the American College of Rheumatology 1986 clinical criteria guidelines.
3. Western Ontario and McMaster University Arthritis Index (WOMAC) pain subscale score in the range of 7-15 (to minimize including subjects with knee OA so severe they may be better served by arthroplasty)
4. PHQ-9 scores 1-9, with at least one of the cardinal symptoms of depression (low mood or anhedonia) endorsed.
5. Modified Mini Mental State (3MS) Examination \>/= 80.
6. Has or is willing to establish care with a personal physician prior to any experimental procedures.

Exclusion Criteria:

1. Major Depressive Episode or anxiety disorder within the past 1 year
2. Currently taking an antidepressant
3. History of bipolar or schizophrenia
4. Drug or alcohol use disorder within the past 12 months
5. Receiving knee-related workers compensation or involved in knee pain-related litigation.
6. Currently taking an anti-anxiety medicine \> 4 times/week for the past 4 weeks.

Answer: D