Please select the eligibility criteria that correspond to the clinical trial below.
Title: The Efficacy of Targinact® Treatment With Respect to Quality of Life (Overall Health Assessment) in Chronic Severe Pain Patients Compared to Previous Analgesic Treatment: a Non-interventional, Observational Study.
Brief Summary: This non-interventional, observational study evaluates the efficacy of Targinact with regard to quality of life in daily clinical practice in Belgium compared to the previous analgesic treatment.


Options:
A: Inclusion criteria:

Patients enrolled in the study are patients who

* are eligible for Targinact® treatment according to the Targinact® SPC AND
* who have previously been treated with WHO step 1, 2 or 3 analgesics

Exclusion criteria are based on the Targinact® SPC.
B: Inclusion Criteria:

1. Advanced medical illness with a life expectancy of 1 to 6 months
2. No clinically significant laxation within 48 hours prior to the first dose of study drug
3. On stable opioid and laxative regimen for a least 3 days prior to treatment
4. Age greater than 18years
5. Females of child-bearing age must have a negative pregnancy test.

Exclusion Criteria:

1. Females who are pregnant or nursing.
2. Previous treatment with MNTX or prior treatment with naltrexone or naloxone for treatment of OIC
3. Any disease process suggestive of gastrointestinal obstruction
4. Fecal ostomy.
C: Inclusion Criteria:

* 18 years of age and older
* Negative pregnancy test (serum or urine) at screening for all women of childbearing potential
* Advanced Medical Illness (i.e., terminal illness, such as incurable cancer or end of stage AIDS) with life expectancy of ≥ 1 month
* patient must sign ICF

Exclusion Criteria:

* Women who are pregnant and/or nursing
* Previous treatment with MNTX
* Participation in any other studies involving investigational products within 30 days prior to screening
D: Inclusion Criteria:

* Age ≥ 18 years
* Receiving palliative care
* Life expectancy ≥ 2 weeks
* Able to give informed consent
* Receiving opioid treatment with either morphine sulphate, oxycodone or fentanyl
* Opioid treatment, both

  * On a regular schedule (not just as needed or rescue doses) for the control of pain or dyspnea for at least 2 weeks before the first dose of methylnaltrexone, and
  * On a stable opioid regimen for at least 3 days before the first dose of methylnaltrexone. This is defined as no dose reduction of ≥ 50%, dose increases are permitted. If rescue medication is prescribed of a different type of opioid than the regular dosed opioid, the rescue medication should be switched to the same type as the regular dosed opioid for at least 3 days before the first dose of methylnaltrexone.
* Has diagnosis of constipation, defined as either

  * \< 3 bowel movements during the previous week by history and no clinically notable laxation\* in the 24 hours before the first dose of methylnaltrexone, or
  * No clinically notable laxation\* in the 48 hours before the first dose of methylnaltrexone.
* Constipation is defined as opioid induced, determined by investigator
* On stable laxative regimen for ≥ 3 days before the first dose of methylnaltrexone. This is defined as at least one type of laxative in an adequate dosing regimen, (e.g. macrogol 2 packets daily, magnesium(hydr)oxide 500 mg three times daily, bisacodyl 10 mg daily or sennoside A+B 10 ml daily) or at least two types of laxatives in a suboptimal dose with patient characteristics hampering optimal treatment.
* If the subject is a woman with presumed child bearing potential; negative urine pregnancy test at screening
* Surgically sterile or agrees to use a medically acceptable method of birth control or practice sexual abstinence for the duration of the methylnaltrexone treatment and the following 15 days. \~

  * including laxation after rescue laxative or enema \~ not necessary for postmenopausal women

Exclusion Criteria:

* Previous treatment with methylnaltrexone
* Known or suspected mechanical gastrointestinal obstruction
* Presence of an other cause of bowel dysfunction that is considered to be a major contribution to the constipation according to investigator
* Presence of a peritoneal catheter for intraperitoneal chemotherapy or dialysis
* Clinically relevant active diverticular disease
* History of bowel surgery within 10 days before first dose of methylnaltrexone
* Fecal ostomy
* Use of vinca alkaloids within previous 4 months
* Body weight \<38 kg
* Renal failure defined as EGFR \<30 ml/min per 1.73m2 or requires dialysis.
* Known or suspected allergy to methylnaltrexone or similar compounds (e.g. naltrexone or naloxone)
* Participation in a study with investigational products within 30 days before first dose of methylnaltrexone.
* Pregnant or nursing
* Clinically important abnormalities that may interfere with participation or compliance to the study, determined by investigator

Additional exclusion criteria for the immunologic and angiogenic analysis part of the study:

* Chemotherapy or treatment with tyrosine kinase inhibitor during 4 weeks before inclusion or treatment scheduled during participation in this study.
* Treatment with high dose corticosteroids during 2 weeks before inclusion in this study. This is defined as the equivalent of 30 mg of prednisone per day for ≥ 2 consecutive days.

Answer: A