Please select the eligibility criteria that correspond to the clinical trial below.
Title: Home-based Computerized Cognitive Rehabilitation in Chronic Stage Stroke
Brief Summary: This study evaluates the effectiveness of Guttmann NeuroPersonalTrainer (GNPT), a tele-rehabilitation platform developed as a tool for the cognitive rehabilitation of chronic stroke patients. All patients will receive this treatment but in different order: half will receive GNPT and the other half will receive sham cognitive training; after a washout period of three months, crossover will occur and participants from the GNPT condition will receive sham cognitive training, while participants originally from the control intervention will receive GNPT.


Options:
A: Inclusion Criteria:

1. Ischemic or hemorrhagic stroke occurring at least 6 months prior to enrollment
2. Age range from 20 to 90 years
3. MMSE score ≥ 19
4. MoCA\<26
5. Self- or informant-reported memory or cognitive complaints or CDR scale ≤ 0.5
6. Able to follow the study instruction
7. Adequate cardiopulmonary function to perform aerobic exercise
8. Able to walk with or without assistive devices

Exclusion Criteria:

1. Unstable medical history (e.g., recent myocardial infarction) that might limit participation
2. Concomitant with other neurological disorders (e.g., Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis)
3. Current participation in another interventional trial
B: Inclusion Criteria:

* to be over 18 years old,
* to have been diagnosed with stroke
* an occurrence of the injury of 12 month period ore more (chronic stage)
* cognitive impairment confirmed by pre-intervention neuropsychological assessment

Exclusion Criteria:

* diagnosis of language deficits or aphasia
* motor impairment concerning upper limbs that may incapacitate them for the use of the computer
* severe alteration of the visual field or perceptual problems
* health status that may require further intervention or admission to a medical center during the study;
* neurological or psychiatric history
* substance abuse.
C: Inclusion Criteria:

* Diagnosis of ischemic or hemorrhagic stroke
* Modified Rankin Score (mRS) of \<4 at screening
* Recently discharged from the hospital or rehabilitation program
* Male or female ≥18 years of age
* Less than ideal physical activity ≥ 3 months prior to enrollment (less than ideal physical (as defined by the American Heart Association)
* Able to walk ≥10 meters with or without assistance

Exclusion Criteria:

* Unable to follow instructions for exercise and cognitive interventions
* Any uncontrolled medical condition expected to limit life expectancy or interfere with participation in the trial (i.e. unstable cancer, severe depression or anxiety by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria)
* Abnormal stress test, as determined by the treating physician (unless cardiology clearance provided)
* Active substance abuse or alcohol dependence
* Less than 6th grade reading level
* Uncorrected vision or hearing deficits that would preclude administration of the cognitive measures
* Unwilling or unable to provide written informed consent
D: Inclusion Criteria:

* Acute Stroke (\<3 months since the discharge to their homes)
* A score from 20 to 50 on Barthel Index
* A score from 35 to 75 on Functional Independence Measure

Exclusion Criteria:

* Severe cognitive impairment (scoring 0-17 in the Mini-Mental State Examination)
* Inability to walk 3 meters without physical assistance
* Inability to stay standing more than 30 "without physical support
* Serious communication or comprehension problems
* Surgical intervention in lower limbs 12 months prior to recruitment
* Secondary neurological pathology
* Severe cardiovascular, respiratory, orthopedic or metabolic problems

Answer: B