Please select the eligibility criteria that correspond to the clinical trial below.
Title: Effect of Transcranial Direct Current Stimulation and Electro Acupuncture in Pain, Functional Capability and Cortical Excitability in Patients With Osteoarthritis.
Brief Summary: The objective of this study is to evaluate the efficacy of transcranial direct current stimulation (tDCS) and electro acupuncture (EAC) compared to sham treatment in reducing pain, improving functional capacity and functioning of the neuro-immune-endocrine system in patients with chronic pain due to knee osteoarthritis.


Options:
A: Inclusion Criteria:

* English speaking adults (\>18 years of age)
* Provided with a diagnosis of knee OA by a physician
* Self-report of having experienced pain and disability related to knee OA for at least 6 months.

Exclusion Criteria:

* Skin conditions in which application of phototherapy may be contra-indicated (skin cancer, people receiving radiation therapy)
* History of total joint arthroplasty of the affected knee
* Red flags suggestive of non-musculoskeletal etiology (i.e. fever/chills, unrelenting night pain, multi-segmental or bilateral loss of sensation, sudden unexplained weight loss).
B: Inclusion Criteria:

* diagnosed (and radiologically verified) I-III stage knee osteoarthritis, has no contraindications (exclusion criteria) to participate in research, are willing to follow studies protocol and gives informed approval to participate in this research in written form.

Exclusion Criteria:

* Rheumatoid arthritis or other systemic rheumatoid disease (LE, sclerodermia,.. etc)
* Fragile, very sensitive skin or it's lesions in areas where tapes are to be applied
* Inability to do functional tests according study protocol due to very impaired knee function or severe comorbidities.
* Diagnosed or suspected cancer in areas where tapes to be applied
* \< than 6 months after intra-articular injections in knee joint
* Constant usage of analgesic medicament due to comorbidities
* Pregnancy
* History of Kinesio Taping method applications in the past
* Need for orthotics
* Unwillingness not to use local ointments in knee region during participation in study period (i.e. 2 months)
C: Inclusion Criteria:

* 40 years of age or older
* Meet the American College of Rheumatology (ACR) clinical criteria for a diagnosis of knee OA. The ACR clinical criteria for knee OA includes knee pain plus 3 of the following 6 criteria:
* age \> 50 years,
* morning stiffness of \< 30 minutes,
* crepitus on active movement,
* tenderness of the bony margins of the joint,
* bony enlargement of the joint noted on exam,
* lack of palpable warmth of the synovium. Based on this criteria, a subject who is less than 50 years but has knee pain and 3 of the other 5 criteria would also be classified as having knee OA.

Exclusion Criteria:

* do not meet the ACR clinical criteria for knee OA,
* are scheduled for total knee arthroplasty (TKA) surgery,
* have undergone TJA surgery on any lower extremity joint,
* exhibit uncontrolled hypertension (i.e. individuals not currently taking medication for hypertension whose systolic blood pressure is greater than 140 mm Hg or diastolic blood pressure greater than 90 mm Hg at rest),
* have complaints of low back pain or other lower extremity joint pain that affects function at the time of recruitment,
* have a history of neurological disorders that would affect lower extremity function (stroke, peripheral neuropathy, parkinson's disease, multiple sclerosis, etc.),
* are women who are pregnant.
D: Inclusion Criteria:- Provision of informed consent to participate.

* Women with over 18 years old,with chronic pain because of primary osteoarthritis of the knee.
* Pain stable for at least three months. Score greater than or equal to 3 cm (0 cm = "no pain" and "worst possible pain" = 10cm) on Visual Analog Scale (VAS) for pain perception at baseline.
* No contraindications to electroacupuncture, transcranial direct current stimulation or transcranial magnetic stimulation.

Exclusion Criteria:-Clinically significant or unstable disorder, medical or psychiatric.

* Presence of neurological or rheumatic comorbidity.
* Pregnancy.
* Already having been treated with acupuncture.
* Having performed with corticosteroid infiltration in the last six weeks or are using this.
* Having performed with hyaluronic acid infiltration in the last year.
* Previous surgery on the limb to be treated or have surgical program for the next 6 months.

Answer: D