Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Etoricoxibe - Preemptive and Postoperative Analgesia for Abdominal and Thoracic Surgery
Brief Summary: This randomised placebo controlled double-blinded bicentre study (phase III) was designed to evaluate the preemptive and postoperative analgetic impact of etoricoxibe in open abdominal and thoracic surgery. Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2).

Therefore 120 patients (ASA-risk 1-2) with upcoming abdominal or thoracic surgery should be included into this study. Patients are randomly allocated to either the preemptive or the postoperative Etoricoxibe group. These two groups are divided each into two arms. Preemptive group patients get Etoricoxibe either twice (before and after surgery) or just a single preoperative dose. Postoperative group patients get placebo before surgery and either a drug application or a placebo again after surgery (so called 2x2 factorial study design).

Cumulative use of morphine as assessed within first 48 hours after surgery is the primary trial outcome indicating the analgesic potency of Etoricoxibe.

In addition, changes in patients level of sensibilisation will be measured with help of quantitative sensory testing (a standardised procedure) before and after surgery (secondary outcome). In addition pharmacogenetic testing will provide information about genetic aberrations (so called polymorphisms) of the patients enzymes that should be compared to the individual reaction regarding Etoricoxibe.

The results will give hint about the analgesic impact of etoricoxibe in acute postoperative pain. There will be findings for preemptive analgesia and nerval processes. All this could lead to an improvement of postoperative pain relief while administrating preemptively a COX-2 selective inhibitor before surgery.


Options:
A: Arm Label: Dexketoprofen trometamol; Type: EXPERIMENTAL; Interventions: Drug: Dexketoprofen trometamol | Arm Label: Preoperative control; Type: PLACEBO_COMPARATOR; Interventions: Drug: Preoperative control | Intervention Type: DRUG; Name: Dexketoprofen trometamol; Assigned to Arm(s): Dexketoprofen trometamol | Intervention Type: DRUG; Name: Preoperative control; Assigned to Arm(s): Preoperative control
B: Arm Label: Treatment A:; Type: ACTIVE_COMPARATOR; Interventions: Drug: Paracetamol (1g x 4), Drug: Ibuprofen (400 mg x 4) | Arm Label: Treatment B:; Type: ACTIVE_COMPARATOR; Interventions: Drug: Paracetamol (1g x 4), Drug: Placebo (x4) | Arm Label: Treatment C:; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ibuprofen (400 mg x 4), Drug: Placebo (x4) | Arm Label: Treatment D:; Type: ACTIVE_COMPARATOR; Interventions: Drug: Paracetamol (0,5 g x 4), Drug: Ibuprofen (200 mg x 4) | Intervention Type: DRUG; Name: Paracetamol (1g x 4); Assigned to Arm(s): Treatment A:, Treatment B: | Intervention Type: DRUG; Name: Ibuprofen (400 mg x 4); Assigned to Arm(s): Treatment A:, Treatment C: | Intervention Type: DRUG; Name: Paracetamol (0,5 g x 4); Assigned to Arm(s): Treatment D: | Intervention Type: DRUG; Name: Ibuprofen (200 mg x 4); Assigned to Arm(s): Treatment D: | Intervention Type: DRUG; Name: Placebo (x4); Assigned to Arm(s): Treatment B:, Treatment C:
C: Arm Label: Preemptive; Type: ACTIVE_COMPARATOR; Interventions: Drug: Etoricoxibe | Arm Label: Postoperative; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Etoricoxibe; Assigned to Arm(s): Preemptive | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Postoperative
D: Arm Label: Group ETORICOXIB PREOP; Type: EXPERIMENTAL; Interventions: Drug: Etoricoxib, Drug: Placebo | Arm Label: Group ETORICOXIB POSTOP; Type: EXPERIMENTAL; Interventions: Drug: Etoricoxib, Drug: Placebo | Arm Label: Group PLACEBO; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Etoricoxib; Assigned to Arm(s): Group ETORICOXIB POSTOP, Group ETORICOXIB PREOP | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Group ETORICOXIB POSTOP, Group ETORICOXIB PREOP, Group PLACEBO

Answer: C