Please select the eligibility criteria that correspond to the clinical trial below.
Title: Buying Time: Improving Sleep to Promote Cognitive Function in Older Adults
Brief Summary: The purpose of this study is to investigate whether a comprehensive group education combined with a lifestyle "activation" program that includes (a) sleep hygiene course, (b) physical activity promotion, and (c) bright light therapy, can improve both sleep quality and cognitive function among 96 community-dwelling older adults.


Options:
A: Inclusion Criteria:

* Male or post-menopausal female out-patients diagnosed with Alzheimer's disease
* Patients should have mild to moderate dementia as evidenced by a Mini-Mental State Examination score of 10-24 inclusive at screening
* The patient must show a history of cognitive decline that has been gradual in onset and progressive over a period of at least six months
* There must be evidence of sustained memory deterioration in an otherwise alert patient, plus additional impairment in at least one of the following five areas: orientation, judgement and problem solving, functioning in community affairs, functioning in home and hobbies, or functioning in personal care
* The caregiver resides with the patient and is able to speak with the investigative team about the patient's activities, medication use and adverse events. In addition, the caregiver will participate in assessment interviews and complete questionnaires for themselves and the patients. The caregiver will monitor their own sleep, the patient's sleep, and complete questionnaires regarding sleep patterns and care giving activities

Exclusion Criteria:

* Neurodegenerative disorders such as Parkinson's disease, Pick's disease or Huntington's chorea, Down's syndrome, Creutzfeldt-Jacob disease
* One of the following conditions possibly resulting in cognitive impairment: acute cerebral trauma or injuries secondary to chronic trauma, hypoxic cerebral damage, e.g., post resuscitation (cardiac arrest, post anesthesia, secondary to severe self-poisoning episode, or secondary to severe hypovolemia)
* Patients with the following medical conditions: any history of epilepsy or convulsions except for febrile convulsions during childhood, clinically significant: endocrine disease, metabolic disease, psychiatric disease, cardiovascular disease, peptic ulcer disease, hepatic disease, renal disease, pulmonary disturbances or urinary outflow obstruction
* Use of any agent for the treatment of dementia (approved, experimental or over the counter agents) including patients who have previously received tacrin, donepazil, metrifonate, rivastigmine tartrate, galantamine, or memantine for treatment of Alzheimer's disease
B: Inclusion Criteria:

* A clinical diagnosis of Alzheimer's disease or Mild Cognitive Impairment
* Subjective complaint of sleep disruption, unsatisfactory sleep, early morning awakening, early bedtime, or excessive daytime sleepiness. Such complaint can be made by either the potential participant or by the caregiver.

Exclusion Criteria:

* Participation in any other clinical drug trial
* Liver failure
* Believed by the investigator to be unwilling or unable to follow the protocol
* Active liver or coronary disease
C: Inclusion Criteria:

* \>= 55 Years old
* MMSE 14-26
* Prodromal Alzheimer's Disease (AD), AD or Mild Cognitive Impairment (MCI) due to AD
* Participation of a caregiver

Exclusion Criteria:

* Profound hearing or visual impairment
* Seizure Disorder
* Use of memantine (Namenda or Namzaric)
* Implantable devices (non-MR compatible)
D: Inclusion Criteria:

* Sleep complaints
* Community-dwelling (not in a long term care facility)
* Read, write, and speak English
* Able to walk independently
* In sufficient health to participate in regular physical activity

Exclusion Criteria:

* Diagnosis of obstructive sleep apnea
* Receiving continuous positive air pressure (CPAP) treatment
* Diagnosed with dementia of any type
* At high risk for cardiac complications during physical activity or unable to self-regulate activity or understand recommended activity level
* Have a clinically important peripheral neuropathy or sever musculoskeletal or joint disease that impairs mobility

Answer: D