Please select the outcome measures that correspond to the clinical trial below.
Title: Effects of NAC Supplementation on Skeletal Muscle Performance Following Aseptic Injury Induced by Exercise
Brief Summary: In this investigation the investigators utilized NAC administration to foster GSH availability during an 8-day period following eccentric exercise-induced muscle damage in order to test our hypotheses: i) antioxidant supplementation does not disturb performance and adaptations induced by exercise-induced muscle injury and ii) redox status perturbations in skeletal muscle are pivotal for the regulation of muscle' inflammatory response and repair.


Options:
A: Change in reduced glutathione in blood (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in reduced glutathione in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise); Change in protein carbonyls in red blood cells and serum (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in protein carbonyls in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise); Change in thiobarbituric acid reactive substances in red blood cells and serum (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in thiobarbituric acid reactive substances in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise); Change in oxidized glutathione in red blood cells and blood (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in total antioxidant capacity in serum (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in oxidized glutathione in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise); Change in catalase activity in red blood cells and serum (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in glutathione peroxidase activity in red blood cells (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in creatine kinase activity in plasma (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in C-reactive protein in plasma (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in macrophage infiltration in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise); Change in white blood cell count in blood (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in neutrophil count in blood (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in fatty acid binding protein in plasma (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in cortisol concentration in blood (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in testosterone concentration in plasma (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in cytokine concentration in plasma (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in adhesion molecule concentration in blood (one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise); Change in intracellular signalling proteins in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise); Change in myogenic determination factor (MyoD) protein levels in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise); Change in tumor necrosis factor α in muscle (one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise)
B: Improvement of muscle effort tolerance after antioxidant supplementation (duration study 3 years)
C: Change in physical performance from using Placebo to using Pomegranate juice (3min after Placebo and Pomegranate training sessions); Change in Acute Hematological responses from using Placebo to using Pomegranate juice (3min after Placebo and Pomegranate training sessions); Change in Acute Biochemical responses from using Placebo to using Pomegranate juice (3min after Placebo and Pomegranate training sessions); Change in Delayed Hematological responses from using Placebo to using Pomegranate juice (48h after Placebo and Pomegranate training sessions); Change in Delayed Biochemical responses from using Placebo to using Pomegranate juice (48h after Placebo and Pomegranate training sessions)
D: PGC-1alpha mRNA expression in skeletal muscle PPARgamma mRNA expression in skeletal muscle Serum malondialdehyde concentration (after 4 weeks)

Answer: A