Please select the eligibility criteria that correspond to the clinical trial below.
Title: Multicentre Controlled, Randomized Clinical Trial to Compare the Efficacy and Safety of Ambulatory Treatment of Mild Acute Diverticulitis Without Antibiotics With the Standard Treatment With Antibiotics
Brief Summary: Patients with mild acute diverticulitis (modified Neff 0 grade), following the inclusion criteria and giving informed consent, will be included in the study protocol and will be randomly assigned to one of the treatment arms: symptomatic treatment with NSAID plus antibiotic vs symptomatic treatment with NSAID only. They will be followed-up at 48 hours, 7 days, 30 days and 3 months from the onset of the episode.


Options:
A: Inclusion Criteria:

* Patient's written informed consent. Adequate cognitive capacity.
* Adequate family support
* No acute diverticulitis episode in the last 3 months
* mNeff 0 acute diverticulitis (abdominal computed tomography scan)
* No antibiotic treatment in the last 2 weeks
* Immunocompetence\*
* No significant comorbidities\*\*
* Good oral tolerance
* Good symptom control
* Maximum one of the following SIRS criteria (\* T\>38 ºC or \<36ºC, L\>12,000 or \<4000/uL, HR\>90 bpm, RR\<20 rpm) or CRP\>15 mg/dL

Exclusion Criteria:

* Women in pregnancy or breastfeeding
* Age \<18 years or \> 80 years.
* Absence of the patient's written informed consent. Inadequate cognitive capacity.
* Inadequate family support
* Acute diverticulitis episode in the last 3 months
* Moderate acute diverticulitis (mNeff grade I or upper)
* Antibiotic treatment in the last 2 weeks
* Inflammatory bowel disease
* Immunodepression\*
* Presence of significant comorbidities\*\*
* Bad oral tolerance
* Poor symptom control
* More than one of the following SIRS criteria (\* T\>38 ºC or \<36ºC, L\>12,000 or \<4000/uL, HR\>90 bpm, RR\<20 rpm) or CRP\>15 mg/dL

(\*) Immunocompetence is the absence and immunodepression is the presence of any of the following: active neoplastic disease/hematologic malignancy/HIV with low CD4+ count/long-term corticosteroid treatment/immunosuppressant therapy/transplant/splenectomy/genetic immunodeficiency.

(\*\*) We consider significant comorbidities any of the following: poorly controlled diabetes mellitus (HbA1\>7mg/dl), cardiologic event in the last 3 months, decompensation of hepatopathy in the last 3 months, renal chronic insufficiency in dialysis programme.
B: Inclusion Criteria:

* adults with CT sign of acute colonic uncomplicated diverticulitis
* elevated CRP and LPK
* Temp.38c or more

Exclusion Criteria:

* patients with peritonitis, sepsis or CT- sign of complicated diverticulitis with abscesses or free abdominal air
* pregnancy
* immunological incompetence and immunosuppressive therapy
C: Inclusion Criteria:

* Only left-sided uncomplicated (mild) acute diverticulitis;
* Clinical suspicion of acute diverticulitis. For acute diagnostic work-up: ultrasound or CT proven diverticulitis. In the case of diverticulitis-negative ultrasound in clinically suspected patients an intravenous contrast-enhanced CT scan is mandatory for confirmation of diverticulitis or exclusion of other pathology. CT for Hinchey/Ambrosetti classification (which is a CT-based classification system) is needed for all patients, but can be delayed 1 day in those with ultrasound diagnosis. Staging diverticulitis is defined according the modified Hinchey/Ambrosetti staging, only stages 1a and 1b and "mild" diverticulitis (1a Confined pericolic inflammation, 1b Confined small (smaller than 5cm) pericolic abscess) are included;
* All patients with informed consent.

Exclusion Criteria:

* Previous radiological (ultrasound and/or CT) proven episode of diverticulitis;
* Colonic cancer;
* Inflammatory bowel disease (ulcerative colitis, Crohn's disease);
* Hinchey stages 2, 3 and 4 or "severe" diverticulitis according to the Ambrosetti criteria, which require surgical or percutaneous treatment;
* Disease with expected survival of less than 6 months;
* Contraindication for the use of the study medication (e.g. patients with advanced renal failure or allergy to antibiotics used in this study);
* Pregnancy, breastfeeding;
* ASA (American Society of Anaesthesiologists) classification \> III;
* Immunocompromised patients;
* Clinical suspicion of bacteraemia (i.e. sepsis);
* The inability of reading/understanding and filling in the questionnaires;
* Antibiotic use in the 4 weeks before admittance.
D: Inclusion Criteria:

* Right-sided colonic diverticulitis
* Uncomplicated diverticulitis

Exclusion Criteria:

* Pregnancy
* Refuse to investigation
* Immunosuppressive therapy or immunologic incompetence
* Colonic diverticulitis except right-sided diverticulitis
* Complicated diverticulitis
* Disorder of psychology or cognition
* Allergic reaction to antibiotics being used in the study (3rd generation cephalosporin, quinolone, metronidazole)

Answer: A