Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Safety of Adenosine 2A Agonist Lexiscan in Children and Adults With Sickle Cell Disease
Brief Summary: Sickle cell disease (SCD) is an inherited blood disorder that causes the red blood cells to change their shape from a round shape to a half-moon/crescent or sickled shape. People who have SCD have a different type of protein that carries oxygen in their blood (hemoglobin) then people without SCD. This different type of hemoglobin makes the red blood cells change into a crescent shape under certain conditions. Sickle-shaped cells are a problem because they often get stuck in blood vessels blocking the flow of blood, and cause inflammation and injury to the important areas in the body. Lexiscan is drug that may prevent this inflammation and injury caused by the sickle shaped cells. This drug is approved by the FDA to be used as a fast infusion during a heart stress test in people who are unable to exercise enough to put stress on their heart by making it beat faster. Lexiscan has never been studied in patients with SCD and has never been given as a long infusion.


Options:
A: Arm Label: Stage 1; Type: EXPERIMENTAL; Interventions: Drug: Lexiscan | Arm Label: Stage 2; Type: EXPERIMENTAL; Interventions: Drug: Lexiscan | Arm Label: Stage 3; Type: EXPERIMENTAL; Interventions: Drug: Lexiscan | Arm Label: Stage 4; Type: EXPERIMENTAL; Interventions: Drug: Lexiscan | Arm Label: Stage 2B; Type: EXPERIMENTAL; Interventions: Drug: Lexiscan | Intervention Type: DRUG; Name: Lexiscan; Assigned to Arm(s): Stage 1, Stage 2, Stage 2B, Stage 3, Stage 4
B: Arm Label: Magnesium group; Type: EXPERIMENTAL; Interventions: Drug: Intravenous Magnesium Sulfate | Arm Label: Placebo group; Type: PLACEBO_COMPARATOR; Interventions: Drug: Normal Saline Placebo | Intervention Type: DRUG; Name: Intravenous Magnesium Sulfate; Assigned to Arm(s): Magnesium group | Intervention Type: DRUG; Name: Normal Saline Placebo; Assigned to Arm(s): Placebo group
C: Arm Label: Placebo Pills and Placebo Liquid; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo Pills and Placebo Liquid | Arm Label: Hydroxyurea Pills and Placebo Liquid; Type: ACTIVE_COMPARATOR; Interventions: Drug: Hydroxyurea | Arm Label: Placebo Pills and Magnesium Pidolate Liquid; Type: ACTIVE_COMPARATOR; Interventions: Drug: Magnesium Pidolate | Arm Label: Hydroxyurea Pills and Magnesium Pidolate Liquid; Type: ACTIVE_COMPARATOR; Interventions: Drug: Hydroxyurea, Drug: Magnesium Pidolate | Intervention Type: DRUG; Name: Hydroxyurea; Assigned to Arm(s): Hydroxyurea Pills and Magnesium Pidolate Liquid, Hydroxyurea Pills and Placebo Liquid | Intervention Type: DRUG; Name: Magnesium Pidolate; Assigned to Arm(s): Hydroxyurea Pills and Magnesium Pidolate Liquid, Placebo Pills and Magnesium Pidolate Liquid | Intervention Type: OTHER; Name: Placebo Pills and Placebo Liquid; Assigned to Arm(s): Placebo Pills and Placebo Liquid
D: Intervention Type: DRUG; Name: hormone replacement therapy; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: estrogens; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: progestins; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: estrogen replacement therapy; Assigned to Arm(s): N/A | Intervention Type: BEHAVIORAL; Name: diet, fat-restricted; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: calcium; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: vitamin D; Assigned to Arm(s): N/A | Intervention Type: BEHAVIORAL; Name: dietary supplements; Assigned to Arm(s): N/A

Answer: A