TrialPanorama/Dataset huggingface dataset:
Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Double-blind, Randomized, Multicenter Study to Evaluate the Safety and Efficacy of Evolocumab, Compared With Ezetimibe, in Hypercholesterolemic Subjects Unable to Tolerate an Effective Dose of a HMG-CoA Reductase Inhibitor Due to Muscle Related Side Effects
Brief Summary: The primary objective of this study was to evaluate the effect of 24 weeks of evolocumab administered subcutaneously (SC) every month, compared with ezetimibe, on low-density lipoprotein cholesterol (LDL-C) levels in adults with high cholesterol who are unable to tolerate an effective dose of a statin due to muscle-related side effects (MRSE).


Options:
A: Inclusion Criteria:

* Male or female ≥ 18 to ≤ 80 years of age
* Subject not at LDL-C goal
* History of statin intolerance
* Lipid lowering therapy has been stable prior to enrolment for at least 4 weeks
* Fasting triglycerides ≤ 400 mg/dL

Exclusion Criteria:

* New York Heart Association (NYHA) III or IV heart failure
* Uncontrolled cardiac arrhythmia
* Uncontrolled hypertension
* Type 1 diabetes
* Poorly controlled type 2 diabetes
* Uncontrolled hypothyroidism or hyperthyroidism
B: Inclusion Criteria:

* Clinically stable participants may be eligible to enroll within 10 days following hospital admission with high-risk acute coronary syndrome (either ST-elevation myocardial infarction \[STEMI\] or Non-STEMI or unstable angina)
* Participants not taking a statin must have an LDL-C of 125 mg/dl or less. Participants taking a statin must have an LDL-C of 100 mg/dl or less.

Exclusion Criteria:

* Pregnant or lactating woman, or intending to become pregnant
* Participant with active liver disease or persistent unexplained serum transaminase elevation
* History of alcohol or drug abuse
* History of sensitivity to statin or ezetimibe
* A participant for whom discontinuation of existing lipid lowering regimen poses an unacceptable risk.
C: Inclusion criteria:

* Participants with heterozygous familial hypercholesterolemia who were not adequately controlled with their lipid-modifying therapy.

Exclusion criteria:

* Age \< 18 years
* LDL-C \< 160 mg/dL (\< 4.14 mmol/L) at the screening visit (Week-3).
* Fasting serum triglycerides \> 400 mg/dL (\> 4.52 mmol/L) during the screening period.
* Known history of homozygous familial hypercholesterolemia.

The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.
D: Inclusion criteria:

Healthy subjects.

Exclusion criteria:

Healthy subjects with history or presence of clinically relevant illness.

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Answer: A
Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Randomized Controlled SMS Intervention For Improving Medication Adherence in Adult Stroke Patients
Brief Summary: The impact of medications used for secondary stroke prevention relies heavily upon patient adherence. Adherence is defined as "the extent to which a person's behavior - taking medication, following a diet, and/or executing lifestyle changes, corresponds with agreed recommendations from a health care provider." It is said that optimal adherence to medications may reduce the risk of a poor outcome by 26%.

The purpose of this study which is a non-pharmacologic behavioral study is to encourage adherence to medications in stroke survivors by tailored and specific SMS reminders. (Short Text Messages). These SMS reminders will support and assist stroke patients to take medications as prescribed and on time. We hypothesise that SMS will improve the adherence of patients to stroke medications by 2 points on the Morisky Medication Adherence Scale.


Options:
A: Inclusion Criteria:

* Adults (\> 18 years)
* Heart failure of any etiology
* Vulnerable period after episode of acute decompensation
* Cellular telephony acess;
* Left Ventricular Ejection Fraction (LVEF \<40%),

Exclusion Criteria:

* Cardiac transplant wait list;
* Surgical or percutaneous (coronary or valvular) treatment at last 3 months
* HF terminal ;
* Life expectancy \<1 year;
* Another drug or device study at last 30 days
* Prior randomization in the study
B: Inclusion Criteria:

* Participants with coronary artery disease defined as history of myocardial infarction and PCI
* History of diabetes
* Capability to read and send text messages

Exclusion Criteria:

* Assumed poor adherence
* Do not have an active mobile phone
C: Inclusion Criteria:

* Adults \> 18 years
* Diagnosed with stroke at least one month ago on neuroimaging (CT or MRI)
* Taking more than one drug for risk factor control
* Possessing a personal mobile phone
* Modified Rankin scores \<3 (to exclude severely disabled persons)
* Able to operate sms
* Do not intend to travel outside the country in the next 2 months (because the followup period is 2 months and during this period mobile communication through sms is required)
* Give informed consent

Exclusion Criteria:

* Chronic Renal Failure (because such patients keep getting admitted often and also have several contraindications for therapy)

  * Any known malignancy
  * Enrolled in another study
D: Inclusion criteria for participants are:

* having a medical diagnosis of CHD
* being eighteen years old or older
* having an antihypertensive medication regimen that lasts for forty-nine days or more at the enrollment
* being able to read messages through mobile phone
* having a mobile phone which can receive messages from WeChat, and can receive daily reminders from BB Reminder
* having no obvious cognitive impairment
* patients with comorbidities can be included in the study, but during the study, antihypertensive medications are their only prescribed medications (this will be screened by the cardiologist).

Answer: C
Please select the eligibility criteria that correspond to the clinical trial below.
Title: German: Effekte Eines Telemonitorisch überwachten Ergometertrainings Bei Patienten Mit Einer COPD Nach Exazerbation: Eine Prospektiv Randomisierte Studie
Brief Summary: Home ergometer training combined with online monitoring and regular telephone support could prove to be a cost-effective method to improve physical performance and quality of life in COPD patients.

The primary objective of the study is to demonstrate a significantly higher daily workout time in patients that are monitored during home ergometer training with telephone support compared to conventional home ergometer training. Consequently we expect an increased quality of life related to the illness and a decreasing BODE-Index. A post-interventional lower BODE-Index correlates with a reduced risk of hospitalisation and mortality.


Options:
A: Inclusion Criteria:

* A diagnosis of COPD (FEV1/FVC \< 70% in a stable phase of the disease)
* Age \> 18 years
* Referred for conventional COPD rehabilitation
* Compliant patient willing to fulfill the study requirements
* Signed informed consent (Oxygen therapy is not an obstacle for participation).

Exclusion Criteria:

* Musculoskeletal disorders limiting training
* Dizziness, significant sensory or motor disabilities, dementia or terminal malignant disease precluding training
* Severe comorbidities such as i.e. unstable heart disease, dysregulated diabetes, known malignant disease, any other illness making the patient inappropriate for participating in the study
* Non-compliant patient
* Severe vision or hearing impairment
* Non-Danish speaking
* Unwillingness or inability to follow the protocol
* COPD exacerbation in the preceding 6 weeks
B: Inclusion Criteria:

* participants must have a diagnosed COPD, be over 40 years and have no other medical barriers to participate in training at home with the e-health program.

Exclusion Criteria:

* medical barriers to participate in training at home with the e-health program.
C: Inclusion Criteria:

* COPD

Exclusion Criteria:

* tumor diseases
* unstable coronary heart disease
* untreated cardiac valve disease
* incapable of giving consent
D: Inclusion Criteria:

* confirmed diagnosis of COPD by spirometry (post-bronchodilator FEV1/FVC \< 0.70);
* at least 2 self-reported exacerbations in the previous 12 months, i.e. a change for ≥ 2 consecutive days in either ≥ 2 major symptoms (dyspnea, sputum purulence, sputum amount) or any 1 major symptom plus any ≥ 1 minor symptoms (colds, wheeze, sore throat, cough).

Exclusion Criteria:

* severe co-morbid conditions that prohibit participation;
* unable to communicate in the Dutch language;
* difficulties using a smartphone;

Answer: C
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Effectiveness of Chlorhexidine Wipe for Prevention of Multidrug-resistant Organisms in Intensive Care Unit Patients
Brief Summary: The purpose of this study is to determine 2% chlorhexidine wipes are effective in preventing of colonization of multi-drug resistant bacteria in intensive care unit patients.


Options:
A: Inclusion Criteria:

* All patients admitted to study units during the proposed study interval are eligible for inclusion in the study

Exclusion Criteria:

* Patients with known allergies to chlorhexidine gluconate or any other ingredients in the product
* Patients with burns that include a high percentage of disrupted body surface area
* Use in patients undergoing lumbar punctures or contact with the meninges
* Patients with large open skin wounds; and
* Children less than 18 years old
B: Inclusion Criteria:

* Adults over 18 years
* Expected length of stay \> 48h in intensive care unit
* Informed written consent

Exclusion Criteria:

* Cerebral death
* Care limitation
* Neutropenia
* Documented MRSA on admission
* Patients receiving antistaphylococcal topical antibiotics on admission
C: Inclusion Criteria:

* Inclusion criteria will include all HCA hospitals that reside in US states where physicians do NOT routinely prescribe decolonization for MRSA + ICU patients.

Exclusion Criteria:

* Exclusion criteria will include hospitals where ICU physicians often prescribe decolonization for MRSA+ ICU patients.
* Dedicated burn ICUs will also be excluded due to the inability to perform routine bathing.
* Finally, since the intent is to assess the intervention in adult ICUs, pediatric hospitals will be excluded although patients \<13 years old that are admitted to participating adult ICUs will be included in the unit-based intervention.
D: Inclusion Criteria:

* Age \> 18 years
* Admission in critical care unit eg. ICU, respiratory care unit, Cardiac care unit with in 24 hours
* Expected duration of critical care unit admission \> 48 hours

Exclusion Criteria:

* History of chlorhexidine allergy

Answer: D
Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Comprehensive Simulation-based Curriculum as a Means to Enhance Technical and Non-technical Skills in Colonoscopy: a Randomized Control Trial
Brief Summary: Colonoscopy is a commonly used medical procedure. Medical and surgical residents learning colonoscopy typically learn the procedure experientially but simulation based teaching is increasingly being integrated into training programs. The optimal manner to teach colonoscopy on virtual-reality simulators is uncertain. We aim to test a curriculum in simulation-based colonoscopy with self-directed learning on simulators.


Options:
A: Inclusion Criteria:

* post graduate year 1 and 2 general surgical residents
* completed less than 10 laparoscopic cholecystectomies or appendectomies as the primary surgeon
B: Inclusion Criteria:

* Trainee endoscopists from the gastroenterology and general surgery programs at the University of Toronto

Exclusion Criteria:

* Greater than 20 colonoscopies performed
C: Inclusion Criteria:

* GI trainees who met the minimum endoscopy training experience

Exclusion Criteria:

* GI trainees with no endoscopy experience
D: Inclusion Criteria:

* Men and women aged 50-69 years

Exclusion Criteria:

* Personal history of colorectal cancer, colorectal adenoma, colorectal polyposis, or inflammatory bowel disease
* Family history of colorectal polyposis, Lynch syndrome or familial colorectal cancer (2 or more first-degree relatives diagnosed with colorectal cancer or one first-degree relative diagnosed with colorectal cancer before the age of 60)
* Severe comorbidity
* Previous total colectomy
* Not signed informed consent to participate

Answer: B
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Telephone Symptom Management for Advanced Lung Cancer Patients and Caregivers
Brief Summary: The goal of this project is to examine the physical and psychological health benefits of a novel, telephone-delivered symptom management intervention for advanced lung cancer patients and their family caregivers.


Options:
A: Inclusion Criteria:

* Outpatients
* with cancer related pain ≥ 3 on a scale of 0-10 during the last two weeks,
* estimated life expectancy of \> 6 months as assessed by the physician,
* 18 years of age or older,
* able to understand, read and write German,
* have access to a telephone,
* live in a 1 hour distance around Freiburg or are willing to travel to Freiburg for each visit, agree to participate and give written in-formed consent

Exclusion Criteria:

* documented previous or current psychiatric disorder or cognitive impairment as assessed by the physician (that is, unable to understand and provide informed consent),
* visual or hearing impairment that prevents adequate communication,
* a named FC who is not willing to participate in the study
B: Inclusion Criteria:

* Are diagnosed with any type of cancer
* Are over 18 years of age
* Have finished the second chemotherapy cycle
* Expected prognosis of at least 12 months
* Karnofsky level of ≥ 60/100.
* Report three symptoms: fatigue, pain and sleep disturbance at severity level of equal or above 3 during the past 7 days.
* Ability to communicate in Vietnamese

Exclusion Criteria:

* Inability to complete questionnaires or participate in the intervention due to literacy level or communication impairment.
* Have been diagnosed with major psychiatric morbidity such as suicidal tendencies or schizophrenia.

Involved in other clinical trials
C: DISEASE CHARACTERISTICS:

* Diagnosis of cancer AND 1 or both of the following:

  * Clinical depression

    * Depression must be of at least moderate severity (PHQ-9 score ≥ 10)

      * Depressed mood and/or anhedonia endorsed
    * No depression directly precipitated by cancer therapy for which depression is a well known side effect (e.g., interferon, corticosteroids)
  * Cancer-related pain

    * Pain must be at least moderate in severity (Brief Pain Inventory score ≥ 6), persisted despite using ≥ 2 analgesics, and cancer-related
    * If the only pain is due to a pre-existing condition (e.g., migraine, headache, arthritis, etc), the patient may not be eligible

PATIENT CHARACTERISTICS:

* Life expectancy ≥ 6 months
* Must speak English
* Not pregnant
* Fertile patients must use effective contraception
* No moderately severe cognitive impairment
* No schizophrenia or other psychosis
* No disability claim currently being adjudicated for pain

PRIOR CONCURRENT THERAPY:

* See Disease Characteristics
* Not in hospice care
D: Inclusion Criteria:

* Clinical diagnosis of lung cancer
* Must be able to speak and read English

Exclusion Criteria:

* No working phone service
* Does not have a family caregiver

Answer: D
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Randomized Controlled Trial of Adjunctive Social Media for More Effective Contraceptive Counseling
Brief Summary: The scope of this project was to provide evidence that better contraceptive choices are made with more effective counseling as well as improvement in patients' contraceptive knowledge. Specifically we wanted to evaluate the use of social media as a means for effective patient counseling.


Options:
A: Inclusion Criteria:

* currently enrolled in the Cedar Project
* completed main Cedar Project Baseline questionnaire and attended at least one follow-up visit since 2009
* had not tested positive for HIV
* joined study in Vancouver or Prince George
* alive at initiation of Cedar Project mHealth study
B: Inclusion Criteria:

* Reside in the study community
* Must be 16 years or older
* Able and willing to provide informed consent/assent for study procedures
* HIV negative uncircumcised men must be age 16 - 49 years and have access to secure text messaging to be randomized to strategies for male circumcision.

Exclusion Criteria:

* N/A
C: Inclusion/exclusion criteria are generally lenient in order to ensure that our sample is as representative as possible of the overall HIV+/METH+ population.

Inclusion Criteria:

* Ability to provide informed consent
* 18 years or older at the time of enrollment
* HIV-infected
* DSM-IV diagnosis of methamphetamine abuse or dependence in the past 30 days
* Taking at least one medication to treat HIV illness
* Indication of less than 100% adherence to antiretroviral (ART) medication
* Willingness to use electronic monitoring caps to track ART medication
* Willingness to respond to text messages

Exclusion Criteria:

* Axis I psychiatric diagnosis of psychotic disorder or mood disorder with psychotic features
* Presence of a neurological condition (beyond HIV infection) known to impact cognitive functioning (e.g., Huntington's Disease, Stroke)
* Unwillingness or inability to use electronic medication monitoring technology
* Unwillingness or inability to use daily text messaging
D: Inclusion Criteria:

* 18-45 years of age
* English speaking

Exclusion Criteria:

* \<18 or \>45 years old
* Non-English speaking

Answer: D
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Randomized Controlled Trial of Adjunctive Social Media for More Effective Contraceptive Counseling
Brief Summary: The scope of this project was to provide evidence that better contraceptive choices are made with more effective counseling as well as improvement in patients' contraceptive knowledge. Specifically we wanted to evaluate the use of social media as a means for effective patient counseling.


Options:
A: Inclusion Criteria:

* HIV seropositivity
* Being on ART for at least three month
* Age 15 to 19 years as at last birthday
* Use of personal mobile phone
* Poor adherence to ART

Exclusion Criteria:

Adolescents who are too ill to require hospital admission will be excluded from the study.
B: Inclusion Criteria:

* 18-45 years of age
* English speaking

Exclusion Criteria:

* \<18 or \>45 years old
* Non-English speaking
C: Inclusion Criteria:

* The inclusion criteria includes being a child from the HDSS site, being less than 14 days of age with parent/guardian or at least one person in the household having a working mobile phone connection and parent/guardian providing consent to participate in the study.

Exclusion Criteria:

* The exclusion criteria includes a child from outside HDSS area or family plans to stay in the catchment area for less than 20 weeks
D: Inclusion Criteria:

Women between 18 and 40 years old are eligible for inclusion if they have had a safe normal delivery of a live infant delivery at a Jacaranda Health facility. Eligible women must reside in a 20 km radius from the Jacaranda Health's hospital facility in peri-urban Nairobi. Women must provide a phone number to where they expect that can be reached 2 weeks postpartum.

Exclusion Criteria:

Women who elect to leave the Jacaranda Health facility before the recommended 24 hours, against medical advice, postpartum are not eligible to participate in the postpartum care study. Women and their newborns who are referred to another hospital for higher level emergency obstetric or neonatal care will not be eligible to participate. Women who relocate outside the defined geographic area surrounding the hospital after their delivery are also not eligible.

Answer: B
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Take a Stand ! - a Cluster Randomized Controlled Intervention Study at Four Office-based Workplaces Aiming to Reduce Occupational Sitting Time
Brief Summary: The purpose of the study is to test an intervention aiming to reduce sitting time during work hours among office workers.

Expectations according to outcome measures: Sitting time reduced by 1 hour pr. day (primary). Number of prolonged periods reduced by 1 pr. day (primary). Number of breaks increased by 3 pr. day (primary). 20 % of participants report a reduction of musculoskeletal pain (secondary). A reduction in waist circumference of 1 cm (secondary). A reduction of 0.5 % in bodyfat (secondary).


Options:
A: Inclusion Criteria:

* regional Northern California KP employees

Exclusion Criteria:

* none
B: Inclusion Criteria:

* being employed

Exclusion Criteria:

* not being able to stand
C: Inclusion Criteria:

* Overweight and moderate obese patients (BMI: 25-34,9 kg/m2).
* Be 6 or more than 6 hours daily sitting.
* Able to walk and stand up from a chair unaided.
* Subjects who can guarantee a year continuity in the study.

Exclusion Criteria:

* Recommended contradictions to advising physical activity to overweight and obese people.
* Have an obesity surgical operation.
D: Inclusion Criteria:

1. Workplaces should be:

   * Office-based with sedentary workers
   * Able to include four sections of about equal size (about 25 people) and which could be separated to minimize spill-over effects (e.g. four different addresses, buildings or floors).
   * Have a management willing to collaborate about the project by participating at meetings and at kick-off.
   * Should have at least some financial resources to make structural changes at the work place.
2. Individuals should be:

   * Adults \>18 years
   * Sedentary office-based work-
   * Understanding of Danish
   * Without sickness or disabilities affecting their ability to stand or walk
   * Not pregnant
   * Working more than 4 days a week (\>30 h)

Exclusion Criteria:

* Not providing signed informed consent.

Answer: D