Please select the eligibility criteria that correspond to the clinical trial below.
Title: Demonstration of the Effectiveness of Treatment by Therapeutic Body Wraps in Children and Adolescents Suffering From Autism Spectrum Disorder With Severe Injurious Behavior.
Brief Summary: Severe injurious behaviors in children with autism spectrum disorder are challenging. First line treatment approaches include behavioral techniques but pharmacotherapy is frequently required despite frequent adverse effects in youths.

Therapeutic body wraps has been reported in small series or case reports, but has never been assessed in the context of a randomized controlled trial.

The present study is an exploratory, multicenter, randomized, controlled, open label with blinded outcome assessment (PROBE design) trial of the effect of wet versus dry therapeutic body wraps in children presenting with autism spectrum disorder and severe injurious behavior.


Options:
A: Inclusion Criteria:

1. Adult patient (18 years and older)
2. Knee arthroscopy not combined with open surgery.
3. Patients eligible for surgical treatment.
4. Patients are willing and able to continue study participation to ensure completion of all procedures and observations required by the study.
5. Written informed consent

Exclusion Criteria:

1. Diagnostic arthroscopy
2. Patients concomitantly treated systemically with strong concurrent CYP3A4 and P-gp-inhibitors, i.e. azole-antimycotics or HIV protease inhibitors.
3. Hypersensitivity to the active substance or to any of the excipients of study drug
4. Pregnant women or breast-feeding.
5. Hepatic disease associated with coagulopathy and clinically relevant bleeding risk
6. Known thrombophilia (hereditary or acquired)
7. Mandatory anticoagulation.
8. Known severe bleeding tendency
9. Clinically significant active bleeding.
10. Severe renal failure (GFR\<30mL/min/1.73m2)
11. Patients participating in another clinical trial.
12. Recent mayor surgery (6 to 12 weeks)
B: Inclusion Criteria:

* a current diagnosis of autism, Asperger syndrome, atypical autism according ICD-10 criteria confirmed by specialized clinical assessment;
* presenting severe behavioural disturbances such as hetero and self-injurious behaviours, automutilation, severe motor hyperactivity, severe stereotypies.
* having a systematically consultation by a neuro pediatric.

Exclusion Criteria:

* children with known organic syndrome and/or non-stabilized neuropediatric (e.g. seizures) or medical (e.g. diabetes mellitus) comorbidities.
* patients with stabilized seizure condition, antiepileptic medication should be stable for at least 4 weeks.
C: Inclusion Criteria:

All patients in need of immobilization of the lower leg with a plaster cast (or equivalent of a cast) for a minimum of one week for the following indications:

* Trauma of the lower leg
* Surgery of the lower leg followed by lower leg immobilization with a plaster cast
* Non-traumatic indications

Exclusion Criteria:

* Contra-indications for LMWH use (recent major bleeding, bleeding disorder, allergy)
* Pregnancy
* Pre-existent indication for anticoagulation therapy, either LMWH or vitamin K antagonists.
* History of venous thromboembolism (indication for anticoagulation therapy for prophylaxis of recurrence)
* Mental of physical disability to fulfill study requirements
* Insufficient knowledge of the Dutch language
* Previous participation in the Pot-(K)Cast study
D: Inclusion Criteria:

* Meniscectomy
* Diagnostic Arthroscopy
* Removal of corpora libera

Exclusion Criteria:

* Contra-indications for LMWH use (recent major bleeding, bleeding disorder, allergy)
* Pregnancy
* Pre-existent indication for anticoagulation therapy, either LMWH or vitamin K antagonists.
* History of venous thromboembolism (indication for anticoagulation therapy for prophylaxis of recurrence)
* Mental of physical disability to fulfill study requirements
* Insufficient knowledge of the Dutch language
* Previous participation in the Pot-(K)Cast study

Answer: B