Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Duration of Bronchoprotection of the Long Acting Muscarinic Antagonists Tiotropium and Glycopyrronium Against Methacholine Induced Bronchoconstriction
Brief Summary: The study will assess the duration of protection of single doses of 2 different long acting muscarinic antagonists against methacholine induced bronchoconstriction.


Options:
A: Arm Label: Subjects receiving FF/UMEC/VI (100/62.5/25) mcg+ CIS; Type: EXPERIMENTAL; Interventions: Drug: FF/UMEC/VI, Drug: Albuterol/salbutamol, Device: ELLIPTA DPI, Device: Metered Dose Inhaler, Device: Connected Inhaler System | Arm Label: Subjects receiving FF/UMEC/VI (200/62.5/25) mcg+ CIS; Type: EXPERIMENTAL; Interventions: Drug: FF/UMEC/VI, Drug: Albuterol/salbutamol, Device: ELLIPTA DPI, Device: Metered Dose Inhaler, Device: Connected Inhaler System | Arm Label: Subjects receiving FP/SAL(250/50) mcg + TIO 5 mcg; Type: ACTIVE_COMPARATOR; Interventions: Drug: FP/SAL, Drug: Tiotropium, Drug: Albuterol/salbutamol, Device: DISKUS DPI, Device: RESPIMAT inhaler, Device: Metered Dose Inhaler | Arm Label: Subjects receiving FP/SAL(500/50) mcg + TIO 5 mcg; Type: ACTIVE_COMPARATOR; Interventions: Drug: FP/SAL, Drug: Tiotropium, Drug: Albuterol/salbutamol, Device: DISKUS DPI, Device: RESPIMAT inhaler, Device: Metered Dose Inhaler | Intervention Type: DRUG; Name: FF/UMEC/VI; Assigned to Arm(s): Subjects receiving FF/UMEC/VI (100/62.5/25) mcg+ CIS, Subjects receiving FF/UMEC/VI (200/62.5/25) mcg+ CIS | Intervention Type: DRUG; Name: FP/SAL; Assigned to Arm(s): Subjects receiving FP/SAL(250/50) mcg + TIO 5 mcg, Subjects receiving FP/SAL(500/50) mcg + TIO 5 mcg | Intervention Type: DRUG; Name: Tiotropium; Assigned to Arm(s): Subjects receiving FP/SAL(250/50) mcg + TIO 5 mcg, Subjects receiving FP/SAL(500/50) mcg + TIO 5 mcg | Intervention Type: DRUG; Name: Albuterol/salbutamol; Assigned to Arm(s): Subjects receiving FF/UMEC/VI (100/62.5/25) mcg+ CIS, Subjects receiving FF/UMEC/VI (200/62.5/25) mcg+ CIS, Subjects receiving FP/SAL(250/50) mcg + TIO 5 mcg, Subjects receiving FP/SAL(500/50) mcg + TIO 5 mcg | Intervention Type: DEVICE; Name: ELLIPTA DPI; Assigned to Arm(s): Subjects receiving FF/UMEC/VI (100/62.5/25) mcg+ CIS, Subjects receiving FF/UMEC/VI (200/62.5/25) mcg+ CIS | Intervention Type: DEVICE; Name: DISKUS DPI; Assigned to Arm(s): Subjects receiving FP/SAL(250/50) mcg + TIO 5 mcg, Subjects receiving FP/SAL(500/50) mcg + TIO 5 mcg | Intervention Type: DEVICE; Name: RESPIMAT inhaler; Assigned to Arm(s): Subjects receiving FP/SAL(250/50) mcg + TIO 5 mcg, Subjects receiving FP/SAL(500/50) mcg + TIO 5 mcg | Intervention Type: DEVICE; Name: Metered Dose Inhaler; Assigned to Arm(s): Subjects receiving FF/UMEC/VI (100/62.5/25) mcg+ CIS, Subjects receiving FF/UMEC/VI (200/62.5/25) mcg+ CIS, Subjects receiving FP/SAL(250/50) mcg + TIO 5 mcg, Subjects receiving FP/SAL(500/50) mcg + TIO 5 mcg | Intervention Type: DEVICE; Name: Connected Inhaler System; Assigned to Arm(s): Subjects receiving FF/UMEC/VI (100/62.5/25) mcg+ CIS, Subjects receiving FF/UMEC/VI (200/62.5/25) mcg+ CIS
B: Arm Label: LAMA Treatment; Type: EXPERIMENTAL; Interventions: Drug: Glycopyrronium | Arm Label: uLABA Treatment; Type: EXPERIMENTAL; Interventions: Drug: Indacaterol | Arm Label: Combo Treatment; Type: EXPERIMENTAL; Interventions: Drug: Glycopyrronium, Drug: Indacaterol | Intervention Type: DRUG; Name: Glycopyrronium; Assigned to Arm(s): Combo Treatment, LAMA Treatment | Intervention Type: DRUG; Name: Indacaterol; Assigned to Arm(s): Combo Treatment, uLABA Treatment
C: Arm Label: tiotropium; Type: EXPERIMENTAL; Interventions: Drug: Tiotropium, Device: Respimat, Device: Breezehaler | Arm Label: glycopyrronium; Type: EXPERIMENTAL; Interventions: Drug: glycopyrronium, Device: Respimat, Device: Breezehaler | Intervention Type: DRUG; Name: Tiotropium; Assigned to Arm(s): tiotropium | Intervention Type: DRUG; Name: glycopyrronium; Assigned to Arm(s): glycopyrronium | Intervention Type: DEVICE; Name: Respimat; Assigned to Arm(s): glycopyrronium, tiotropium | Intervention Type: DEVICE; Name: Breezehaler; Assigned to Arm(s): glycopyrronium, tiotropium
D: Arm Label: Fluticasone furoate/GW642444; Type: EXPERIMENTAL; Interventions: Drug: Fluticasone Furoate/GW642444 | Arm Label: Fluticasone propionate; Type: ACTIVE_COMPARATOR; Interventions: Drug: Fluticasone propionate | Intervention Type: DRUG; Name: Fluticasone Furoate/GW642444; Assigned to Arm(s): Fluticasone furoate/GW642444 | Intervention Type: DRUG; Name: Fluticasone propionate; Assigned to Arm(s): Fluticasone propionate

Answer: C