Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Multi-centre, Double-blind, Randomised, Parallel-group, Active Controlled Study to Evaluate the Efficacy, Safety and Tolerability of Tafenoquine (SB-252263, WR238605) in Subjects With Plasmodium Vivax Malaria.
Brief Summary: The purpose of this two part study is to test the safety and efficacy of Tafenoquine (with Cholorquine) as a radical cure for Plasmodium vivax (P.vivax) malaria relative to the control Chloroquine.Part 1 aims to select an efficacious and well tolerated dose that can be co-administered with Chloroquine. Part 2 will investigate the safety and efficacy of the selected dose (300 mg tafenoquine) in the treatment and radical cure of Plasmodium Vivax Malaria.


Options:
A: Arm Label: Tafenoquine 300 milligram (mg) single dose; Type: EXPERIMENTAL; Interventions: Drug: Tafenoquine 150 mg | Arm Label: Matched Placebo 300mg single dose; Type: PLACEBO_COMPARATOR; Interventions: Drug: Matched placebo 150mg | Intervention Type: DRUG; Name: Tafenoquine 150 mg; Assigned to Arm(s): Tafenoquine 300 milligram (mg) single dose | Intervention Type: DRUG; Name: Matched placebo 150mg; Assigned to Arm(s): Matched Placebo 300mg single dose
B: Arm Label: Cohort 1 Tafenoquine; Type: EXPERIMENTAL; Interventions: Drug: Tafenoquine | Arm Label: Cohort 1-Chloroquine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Chloroquine + Primaquine | Arm Label: Cohort 2 Tafenoquine; Type: EXPERIMENTAL; Interventions: Drug: tafenoquine | Arm Label: Cohort 2 Chloroquine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Chloroquine + Primaquine | Intervention Type: DRUG; Name: Tafenoquine; Assigned to Arm(s): Cohort 1 Tafenoquine | Intervention Type: DRUG; Name: Chloroquine + Primaquine; Assigned to Arm(s): Cohort 1-Chloroquine | Intervention Type: DRUG; Name: tafenoquine; Assigned to Arm(s): Cohort 2 Tafenoquine | Intervention Type: DRUG; Name: Chloroquine + Primaquine; Assigned to Arm(s): Cohort 2 Chloroquine
C: Arm Label: Tafenoquine+ Chloroquine; Type: EXPERIMENTAL; Interventions: Drug: Tafenoquine, Drug: Chloroquine, Drug: Primaquine Placebo | Arm Label: Primaquine+ Chloroquine; Type: EXPERIMENTAL; Interventions: Drug: Tafenoquine Placebo, Drug: Chloroquine, Drug: Primaquine | Intervention Type: DRUG; Name: Tafenoquine; Assigned to Arm(s): Tafenoquine+ Chloroquine | Intervention Type: DRUG; Name: Tafenoquine Placebo; Assigned to Arm(s): Primaquine+ Chloroquine | Intervention Type: DRUG; Name: Chloroquine; Assigned to Arm(s): Primaquine+ Chloroquine, Tafenoquine+ Chloroquine | Intervention Type: DRUG; Name: Primaquine; Assigned to Arm(s): Primaquine+ Chloroquine | Intervention Type: DRUG; Name: Primaquine Placebo; Assigned to Arm(s): Tafenoquine+ Chloroquine
D: Arm Label: Tafenoquine 50mg; Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Tafenoquine 50mg | Arm Label: Tafenoquine 100mg; Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Tafenoquine 100mg | Arm Label: Tafenoquine 300mg; Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Tafenoquine 300mg | Arm Label: Tafenoquine 600mg; Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Tafenoquine 600mg | Arm Label: Primaquine 15mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Primaquine 15mg | Arm Label: Chloroquine only; Type: PLACEBO_COMPARATOR; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg | Arm Label: Tafenoquine 300mg (Part 2); Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg (Part 2 ), Drug: Chloroquine 300mg (Part 2 ), Drug: Tafenoquine 300mg (Part 2) | Arm Label: Primaquine 15mg (Part 2); Type: ACTIVE_COMPARATOR; Interventions: Drug: Chloroquine 600mg (Part 2 ), Drug: Chloroquine 300mg (Part 2 ), Drug: Primaquine 15mg (Part2 ) | Arm Label: Chloroquine only (Part 2); Type: PLACEBO_COMPARATOR; Interventions: Drug: Chloroquine 600mg (Part 2 ), Drug: Chloroquine 300mg (Part 2 ) | Intervention Type: DRUG; Name: Chloroquine 600mg; Assigned to Arm(s): Chloroquine only, Primaquine 15mg, Tafenoquine 100mg, Tafenoquine 300mg, Tafenoquine 50mg, Tafenoquine 600mg | Intervention Type: DRUG; Name: Chloroquine 300mg; Assigned to Arm(s): Chloroquine only, Primaquine 15mg, Tafenoquine 100mg, Tafenoquine 300mg, Tafenoquine 50mg, Tafenoquine 600mg | Intervention Type: DRUG; Name: Tafenoquine 50mg; Assigned to Arm(s): Tafenoquine 50mg | Intervention Type: DRUG; Name: Tafenoquine 100mg; Assigned to Arm(s): Tafenoquine 100mg | Intervention Type: DRUG; Name: Tafenoquine 300mg; Assigned to Arm(s): Tafenoquine 300mg | Intervention Type: DRUG; Name: Tafenoquine 600mg; Assigned to Arm(s): Tafenoquine 600mg | Intervention Type: DRUG; Name: Primaquine 15mg; Assigned to Arm(s): Primaquine 15mg | Intervention Type: DRUG; Name: Chloroquine 600mg (Part 2 ); Assigned to Arm(s): Chloroquine only (Part 2), Primaquine 15mg (Part 2), Tafenoquine 300mg (Part 2) | Intervention Type: DRUG; Name: Chloroquine 300mg (Part 2 ); Assigned to Arm(s): Chloroquine only (Part 2), Primaquine 15mg (Part 2), Tafenoquine 300mg (Part 2) | Intervention Type: DRUG; Name: Tafenoquine 300mg (Part 2); Assigned to Arm(s): Tafenoquine 300mg (Part 2) | Intervention Type: DRUG; Name: Primaquine 15mg (Part2 ); Assigned to Arm(s): Primaquine 15mg (Part 2)

Answer: D