Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase IIb, Randomized, Placebo-Controlled, Dose-Finding Clinical Trial to Study the Safety and Efficacy of MK-8237 Using an Environmental Exposure Chamber in Subjects With House Dust Induced Allergic Rhinitis/Rhinoconjunctivitis
Brief Summary: The purpose of this study is to evaluate the dose-related effectiveness, the safety and the tolerability of MK-8237, compared to placebo, in the treatment of house dust mite (HDM)-induced allergic rhinitis/rhinoconjunctivitis in adults. The primary hypothesis is that administration of MK-8237, compared to placebo, results in dose-related improvement in the average total nasal symptom score (TNSS) determined during environmental exposure chamber (EEC) challenge.


Options:
A: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Arm Label: Birch pollen allergen extract; Type: EXPERIMENTAL; Interventions: Biological: Birch pollen allergen extract | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Placebo | Intervention Type: BIOLOGICAL; Name: Birch pollen allergen extract; Assigned to Arm(s): Birch pollen allergen extract
B: Arm Label: MK-8237; Type: EXPERIMENTAL; Interventions: Biological: MK-8237 tablets, Drug: Rescue Medication: Self-Injectable Epinephrine, Drug: Rescue Medication: Loratadine tablets, Drug: Rescue Medication: Olopatadine ophthalmic drops, Drug: Rescue Medication: Mometasone furoate nasal spray | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo tablets, Drug: Rescue Medication: Self-Injectable Epinephrine, Drug: Rescue Medication: Loratadine tablets, Drug: Rescue Medication: Olopatadine ophthalmic drops, Drug: Rescue Medication: Mometasone furoate nasal spray | Intervention Type: BIOLOGICAL; Name: MK-8237 tablets; Assigned to Arm(s): MK-8237 | Intervention Type: BIOLOGICAL; Name: Placebo tablets; Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: Rescue Medication: Self-Injectable Epinephrine; Assigned to Arm(s): MK-8237, Placebo | Intervention Type: DRUG; Name: Rescue Medication: Loratadine tablets; Assigned to Arm(s): MK-8237, Placebo | Intervention Type: DRUG; Name: Rescue Medication: Olopatadine ophthalmic drops; Assigned to Arm(s): MK-8237, Placebo | Intervention Type: DRUG; Name: Rescue Medication: Mometasone furoate nasal spray; Assigned to Arm(s): MK-8237, Placebo
C: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: MK-8237 6 Developmental Units (DU); Type: EXPERIMENTAL; Interventions: Drug: MK-8237 6 DU | Arm Label: MK-8237 12 DU; Type: EXPERIMENTAL; Interventions: Drug: MK-8237 12 DU | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: MK-8237 6 DU; Assigned to Arm(s): MK-8237 6 Developmental Units (DU) | Intervention Type: DRUG; Name: MK-8237 12 DU; Assigned to Arm(s): MK-8237 12 DU
D: Arm Label: Short ragweed pollen allergen extract; Type: EXPERIMENTAL; Interventions: Biological: Short ragweed pollen allergen extract, Drug: Self-injectable epinephrine, Drug: Albuterol/Salbutamol, Drug: Loratadine, Drug: Olopatadine, Drug: Mometasone furoate monohydrate | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo, Drug: Self-injectable epinephrine, Drug: Albuterol/Salbutamol, Drug: Loratadine, Drug: Olopatadine, Drug: Mometasone furoate monohydrate | Intervention Type: BIOLOGICAL; Name: Short ragweed pollen allergen extract; Assigned to Arm(s): Short ragweed pollen allergen extract | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: Self-injectable epinephrine; Assigned to Arm(s): Placebo, Short ragweed pollen allergen extract | Intervention Type: DRUG; Name: Albuterol/Salbutamol; Assigned to Arm(s): Placebo, Short ragweed pollen allergen extract | Intervention Type: DRUG; Name: Loratadine; Assigned to Arm(s): Placebo, Short ragweed pollen allergen extract | Intervention Type: DRUG; Name: Olopatadine; Assigned to Arm(s): Placebo, Short ragweed pollen allergen extract | Intervention Type: DRUG; Name: Mometasone furoate monohydrate; Assigned to Arm(s): Placebo, Short ragweed pollen allergen extract

Answer: C