Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Intermittent Screening and Treatment (IST) or Intermittent Preventive Treatment (IPT) With Dihydroartemisinin-Piperaquine, Versus IPT With Sulfadoxine-Pyrimethamine for the Control of Malaria in Pregnancy in Kenya: a Randomized Controlled Trial
Brief Summary: Malaria in pregnancy (MiP) due to Plasmodium falciparum infection is a major cause of maternal morbidity and poor birth outcomes. Intermittent preventive treatment in pregnancy (IPTp) with Sulfadoxine pyrimethamine (SP), the administration of SP at predefined intervals in the second and third trimesters of pregnancy irrespective of the presence of malaria parasitemia, is currently recommended for HIV-negative women in all areas with stable moderate to high transmission of malaria. Due to increasing resistance to SP, it is no longer used as a treatment for symptomatic malaria, and the efficacy of IPTp-SP seems to be decreased. This study aims to look at a new drug, Dihydroartemisinin-Piperaquine (DP) for IPTp, as well as to explore the strategy of intermittent screening and treatment in pregnancy (ISTp) with DP. This strategy uses increased screening at time of focused antenatal care (FANC) with treatment of women who screen positive.

The hypothesis is that the efficacy of both IPTp-DP and ISTp-DP will be associated with a reduction in malaria infection at delivery among HIV(-) women when compared to IPTp-SP, in an area with decreasing malaria transmission and high levels of SP resistance in Kenya.


Options:
A: Arm Label: IPTp-DHA-PPQ; Type: EXPERIMENTAL; Interventions: Drug: Dihydroartemisinin-piperaquine (DHA-PPQ) | Arm Label: IPTp-Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo Oral Tablet | Intervention Type: DRUG; Name: Dihydroartemisinin-piperaquine (DHA-PPQ); Assigned to Arm(s): IPTp-DHA-PPQ | Intervention Type: DRUG; Name: Placebo Oral Tablet; Assigned to Arm(s): IPTp-Placebo
B: Arm Label: Trial 1: IPTp-SP+LLITNs; Type: ACTIVE_COMPARATOR; Interventions: Drug: Sulphadoxine-pyrimethamine | Arm Label: Trial 1: IPTp-MQ (full dose) + LLITNs; Type: EXPERIMENTAL; Interventions: Drug: Mefloquine (full dose) | Arm Label: Trial 1: IPTp-MQ (split dose)+LLITNs; Type: EXPERIMENTAL; Interventions: Drug: Mefloquine (split dose) | Arm Label: Trial 2: CTX+IPTp-Placebo+LLITNs; Type: EXPERIMENTAL; Interventions: Drug: placebo | Arm Label: Trial 2: CTX + IPTp-MQ+ LLITNs; Type: EXPERIMENTAL; Interventions: Drug: mefloquine | Intervention Type: DRUG; Name: Sulphadoxine-pyrimethamine; Assigned to Arm(s): Trial 1: IPTp-SP+LLITNs | Intervention Type: DRUG; Name: Mefloquine (full dose); Assigned to Arm(s): Trial 1: IPTp-MQ (full dose) + LLITNs | Intervention Type: DRUG; Name: Mefloquine (split dose); Assigned to Arm(s): Trial 1: IPTp-MQ (split dose)+LLITNs | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Trial 2: CTX+IPTp-Placebo+LLITNs | Intervention Type: DRUG; Name: mefloquine; Assigned to Arm(s): Trial 2: CTX + IPTp-MQ+ LLITNs
C: Arm Label: 3 dose SP pregnancy / 3 monthly DP infancy; Type: ACTIVE_COMPARATOR; Interventions: Drug: 3 dose sulfadoxine-pyrimethamine (SP) for adult women during pregnancy, Drug: 3-monthly dihydroartemisinin-piperaquine (DP) for infants | Arm Label: 3 dose DP pregnancy / 3 monthly DP infancy; Type: ACTIVE_COMPARATOR; Interventions: Drug: 3 dose dihydroartemisinin-piperaquine (DP) for adult women during pregnancy, Drug: 3-monthly dihydroartemisinin-piperaquine (DP) for infants | Arm Label: 3 dose DP pregnancy / monthly DP infancy; Type: ACTIVE_COMPARATOR; Interventions: Drug: 3 dose dihydroartemisinin-piperaquine (DP) for adult women during pregnancy, Drug: Monthly dihydroartemisinin-piperaquine (DP) for infants | Arm Label: monthly DP pregnancy / 3 monthly DP infancy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Monthly dihydroartemisinin-piperaquine (DP) for adult women during pregnancy, Drug: 3-monthly dihydroartemisinin-piperaquine (DP) for infants | Arm Label: monthly DP pregnancy / monthly DP infancy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Monthly dihydroartemisinin-piperaquine (DP) for adult women during pregnancy, Drug: Monthly dihydroartemisinin-piperaquine (DP) for infants | Intervention Type: DRUG; Name: Monthly dihydroartemisinin-piperaquine (DP) for adult women during pregnancy; Assigned to Arm(s): monthly DP pregnancy / 3 monthly DP infancy, monthly DP pregnancy / monthly DP infancy | Intervention Type: DRUG; Name: 3 dose dihydroartemisinin-piperaquine (DP) for adult women during pregnancy; Assigned to Arm(s): 3 dose DP pregnancy / 3 monthly DP infancy, 3 dose DP pregnancy / monthly DP infancy | Intervention Type: DRUG; Name: 3 dose sulfadoxine-pyrimethamine (SP) for adult women during pregnancy; Assigned to Arm(s): 3 dose SP pregnancy / 3 monthly DP infancy | Intervention Type: DRUG; Name: Monthly dihydroartemisinin-piperaquine (DP) for infants; Assigned to Arm(s): 3 dose DP pregnancy / monthly DP infancy, monthly DP pregnancy / monthly DP infancy | Intervention Type: DRUG; Name: 3-monthly dihydroartemisinin-piperaquine (DP) for infants; Assigned to Arm(s): 3 dose DP pregnancy / 3 monthly DP infancy, 3 dose SP pregnancy / 3 monthly DP infancy, monthly DP pregnancy / 3 monthly DP infancy
D: Arm Label: IPTp-DP; Type: EXPERIMENTAL; Interventions: Drug: IPTp-DP | Arm Label: ISTp-DP; Type: EXPERIMENTAL; Interventions: Drug: ISTp-DP | Arm Label: IPTp-SP; Type: ACTIVE_COMPARATOR; Interventions: Drug: IPTp-SP | Intervention Type: DRUG; Name: IPTp-SP; Assigned to Arm(s): IPTp-SP | Intervention Type: DRUG; Name: IPTp-DP; Assigned to Arm(s): IPTp-DP | Intervention Type: DRUG; Name: ISTp-DP; Assigned to Arm(s): ISTp-DP

Answer: D