Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC Study) Population
Brief Summary: The project is a passive follow-up of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort. Originally, this was a large, randomized, double-blind, placebo-controlled, 2x2 factorial primary prevention trial testing the effects of alpha-tocopherol and beta-carotene supplementation on cancer incidence and mortality. The study was conducted in Finland as a collaboration between the U.S. National Cancer Institute (NCI) and the National Public Health Institute of Finland. NCI has maintained passive surveillance of the cohort through Finnish national registries, including the cancer registry.

The primary purpose of the ATBC cohort follow-up is to use the existing risk factor data and biological specimens (i.e., serum, whole blood, DNA, red blood cells, and toenails) to test hypotheses relevant to cancer etiology, survival, early detection, and prevention. These data and biospecimens continue to provide an invaluable resource for the study of biochemical, nutritional, genetic, and molecular hypotheses. These analyses are made all the more informative and powerful by the addition of cases identified annually during the follow-up period, and the research benefits from a longer pre-diagnosis period (now over 30 years).


Options:
A: Arm Label: Healthy Volunteers; Type: N/A; Interventions: N/A
B: Intervention Type: DRUG; Name: Natural source Vitamin E 400IU/day; Assigned to Arm(s): N/A
C: Intervention Type: BEHAVIORAL; Name: dietary supplements; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: vitamin C; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: vitamin E; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: beta-carotene; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: folic acid/Vitamin B6/Vitamin B12; Assigned to Arm(s): N/A
D: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Arm Label: 50ug selenium enriched yeast; Type: EXPERIMENTAL; Interventions: Dietary Supplement: 50ug selenium enriched yeast | Arm Label: 100ug selenium enriched yeast; Type: EXPERIMENTAL; Interventions: Dietary Supplement: 100ug selenium enriched yeast | Arm Label: 200ug selenium enriched yeast; Type: EXPERIMENTAL; Interventions: Dietary Supplement: 200ug selenium enriched yeast | Arm Label: Control onion; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Control onion | Arm Label: Enriched onion; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Enriched onion | Intervention Type: DIETARY_SUPPLEMENT; Name: 50ug selenium enriched yeast; Assigned to Arm(s): 50ug selenium enriched yeast | Intervention Type: DIETARY_SUPPLEMENT; Name: 100ug selenium enriched yeast; Assigned to Arm(s): 100ug selenium enriched yeast | Intervention Type: DIETARY_SUPPLEMENT; Name: 200ug selenium enriched yeast; Assigned to Arm(s): 200ug selenium enriched yeast | Intervention Type: DIETARY_SUPPLEMENT; Name: Control onion; Assigned to Arm(s): Control onion | Intervention Type: DIETARY_SUPPLEMENT; Name: Enriched onion; Assigned to Arm(s): Enriched onion | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo

Answer: A