Please select the eligibility criteria that correspond to the clinical trial below.
Title: REducing Deaths Due to OXidative Stress The REDOXS© Study
Brief Summary: The purpose of this study is to determine whether providing high dose glutamine and antioxidants to critically ill patients will be associated with improved survival.


Options:
A: Inclusion Criteria:

1. Deep 2nd and/or 3rd degree burns requiring grafting
2. Patient meets one of the following 4 criteria:

   1. Patients 18 - 39 years of age with ≥ 20% TBSA\* burn
   2. Patients 18 - 39 years of age with ≥ 15% TBSA\* burn and with inhalation injury
   3. Patients 40 - 59 years of age with ≥ 15% TBSA\* burn
   4. Patients ≥ 60 years of age ≥ 10% TBSA\* \*TBSA - Total Body Surface Area

Exclusion Criteria:

1. \> 72 hrs from admission to ICU to time of consent.
2. Patients younger than 18 years of age.
3. a) Patients without known renal disease and renal dysfunction defined as a serum creatinine \>171 µmol/L or a urine output of less than 500 mL/last 24 hours (or 80 mL/last 4 hours if a 24 hour period of observation is not available).

   b) Patients with acute on chronic renal failure (pre-dialysis) with an absolute increase of \>80 µmol/L from baseline or pre-admission creatinine or a urine output of \<500 mL/last 24 hours (or 80 mL/last 4 hours).

   c) Patients with chronic renal failure on dialysis will be excluded.
4. Liver cirrhosis - Child-Pugh class C liver disease
5. Pregnant or lactating females.
6. Contra-indication for EN: intestinal occlusion or perforation, intra-abdominal injury.
7. Patients with injuries from high voltage electrical contact.
8. Patients who are moribund (not expected to survive the next 72 hours).
9. Patients with extreme body sizes: BMI \< 18 or \> 50
10. Enrollment in another industry sponsored ICU intervention study.
11. Received glutamine supplement for \> 24 hrs prior to randomization
12. Known allergy to maltodextrin, corn starch, corn, corn products or glutamine.
B: Inclusion Criteria:

* Age between 18 and 75 years (inclusive).
* Moderate to severe trauma, as defined by an Injury Severity Score (ISS) \> 12 points were included in the study
* Traumatic patients who required total parenteral nutrition

Exclusion Criteria:

* Patients who were under 17 and over 76 years of age,
* Patients whose life expectancy was less than 5 days
* Patientes allergic to glutamine.
* Patients with any basic pathology included any serious immune system condition (diabetes, HIV, lupus, etc.) or who, in their long-term treatment prior to admission to ICU, received corticoids or any other immunosuppressant medication.
* Pregnant women.
C: Inclusion Criteria:

* Age 18-58 years
* Patients admitted with a diagnosis of multiple trauma requiring enteral feeding for \> 48 hours
* Expected length of stay in ICU \> 48 hours
* Has a functional access for enteral tube feeding and a central access for administration of test solution
* Negative Beta HCG (pregnancy test) in females (18-60 years)

Exclusion Criteria:

* Age \< 18 years
* Significant hepatic failure (Patients with Childs C Cirrhosis)
* Severe renal failure (estimated glomerular filtration rate \[eGFR\] \< 50 ml/min)
* Patients with severe metabolic acidosis (pH \<7.35)
* Not expected to be in the ICU \> 48 hours (due to imminent death)
* Unable to tolerate enteral nutrition within 72 hours
* Enrolment in other ICU intervention study if contraindicated
* Patients in whom parenteral nutrition is required from the outset
* Absolute contraindication to enteral nutrition
D: Inclusion Criteria:

* Mechanically ventilated patients \> or = 18 years old
* 2 or more organ failures related to acute illness

Exclusion Criteria:

* \> 24 hours from admission to ICU
* Patients who are moribund
* Lack of commitment to aggressive care
* Absolute contraindication to enteral nutrients
* Severe acquired brain injury
* Routine elective cardiac surgery
* Primary admission of burns \> 30% body surface area
* Weight \< 50 kgms or \> 200 kgms
* Pregnant or lactating patients
* Previous randomization in this study
* Enrollment in a related ICU interventional study
* Child's class C liver disease
* Metastatic cancer with life expectancy \< 6 months
* Seizure disorder requiring anticonvulsant medication

Answer: D