Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Double-Blind Study of the Efficacy and Safety of REGN727 Added-on to Rosuvastatin Versus Ezetimibe Added-on to Rosuvastatin Versus Rosuvastatin Dose Increase in Patients Who Are Not Controlled on Rosuvastatin
Brief Summary: To evaluate the reduction of low-density lipoprotein cholesterol (LDL-C) by alirocumab (REGN727/SAR236553) as an add-on therapy to other LMT in patients with hypercholesterolemia at high cardiovascular (CV) risk.


Options:
A: Arm Label: Evolocumab; Type: EXPERIMENTAL; Interventions: Biological: Evolocumab | Intervention Type: BIOLOGICAL; Name: Evolocumab; Assigned to Arm(s): Evolocumab
B: Arm Label: Rosuvastatin 20 mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Rosuvastatin, Drug: Placebo | Arm Label: Ezetimibe 10 mg + Rosuvastatin 10 mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Rosuvastatin, Drug: Ezetimibe, Drug: Placebo | Arm Label: Alirocumab 75 mg/up to 150 mg + Rosuvastatin 10 mg; Type: EXPERIMENTAL; Interventions: Drug: Alirocumab, Drug: Rosuvastatin, Drug: Placebo | Arm Label: Rosuvastatin 40 mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Rosuvastatin, Drug: Placebo | Arm Label: Ezetimibe 10 mg + Rosuvastatin 20 mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Rosuvastatin, Drug: Ezetimibe, Drug: Placebo | Arm Label: Alirocumab 75 mg/ up to 150 mg + Rosuvastatin 20 mg; Type: EXPERIMENTAL; Interventions: Drug: Alirocumab, Drug: Rosuvastatin, Drug: Placebo | Intervention Type: DRUG; Name: Alirocumab; Assigned to Arm(s): Alirocumab 75 mg/ up to 150 mg + Rosuvastatin 20 mg, Alirocumab 75 mg/up to 150 mg + Rosuvastatin 10 mg | Intervention Type: DRUG; Name: Rosuvastatin; Assigned to Arm(s): Alirocumab 75 mg/ up to 150 mg + Rosuvastatin 20 mg, Alirocumab 75 mg/up to 150 mg + Rosuvastatin 10 mg, Ezetimibe 10 mg + Rosuvastatin 10 mg, Ezetimibe 10 mg + Rosuvastatin 20 mg, Rosuvastatin 20 mg, Rosuvastatin 40 mg | Intervention Type: DRUG; Name: Ezetimibe; Assigned to Arm(s): Ezetimibe 10 mg + Rosuvastatin 10 mg, Ezetimibe 10 mg + Rosuvastatin 20 mg | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Alirocumab 75 mg/ up to 150 mg + Rosuvastatin 20 mg, Alirocumab 75 mg/up to 150 mg + Rosuvastatin 10 mg, Ezetimibe 10 mg + Rosuvastatin 10 mg, Ezetimibe 10 mg + Rosuvastatin 20 mg, Rosuvastatin 20 mg, Rosuvastatin 40 mg
C: Arm Label: Alirocumab 75 mg Q2W/Up to 150 mg Q2W; Type: EXPERIMENTAL; Interventions: Drug: Alirocumab, Drug: Statins, Drug: Antihyperglycemic Drug | Arm Label: Usual Care; Type: ACTIVE_COMPARATOR; Interventions: Drug: Statins, Drug: Ezetimibe, Drug: Fenofibrate, Drug: Nicotinic acid, Drug: Omega-3 fatty acids, Drug: Antihyperglycemic Drug | Intervention Type: DRUG; Name: Alirocumab; Assigned to Arm(s): Alirocumab 75 mg Q2W/Up to 150 mg Q2W | Intervention Type: DRUG; Name: Statins; Assigned to Arm(s): Alirocumab 75 mg Q2W/Up to 150 mg Q2W, Usual Care | Intervention Type: DRUG; Name: Ezetimibe; Assigned to Arm(s): Usual Care | Intervention Type: DRUG; Name: Fenofibrate; Assigned to Arm(s): Usual Care | Intervention Type: DRUG; Name: Nicotinic acid; Assigned to Arm(s): Usual Care | Intervention Type: DRUG; Name: Omega-3 fatty acids; Assigned to Arm(s): Usual Care | Intervention Type: DRUG; Name: Antihyperglycemic Drug; Assigned to Arm(s): Alirocumab 75 mg Q2W/Up to 150 mg Q2W, Usual Care
D: Arm Label: Bococizumab 150mg; Type: EXPERIMENTAL; Interventions: Biological: Bococizumab 150mg | Arm Label: Bococizumab 75mg; Type: EXPERIMENTAL; Interventions: Biological: Bococizumab 75mg | Arm Label: Bococizumab 150mg placebo; Type: PLACEBO_COMPARATOR; Interventions: Biological: Bococizumab 150mg placebo | Arm Label: Bococizumab 75mg placebo; Type: PLACEBO_COMPARATOR; Interventions: Biological: Bococizumab 75mg placebo | Intervention Type: BIOLOGICAL; Name: Bococizumab 150mg; Assigned to Arm(s): Bococizumab 150mg | Intervention Type: BIOLOGICAL; Name: Bococizumab 75mg; Assigned to Arm(s): Bococizumab 75mg | Intervention Type: BIOLOGICAL; Name: Bococizumab 150mg placebo; Assigned to Arm(s): Bococizumab 150mg placebo | Intervention Type: BIOLOGICAL; Name: Bococizumab 75mg placebo; Assigned to Arm(s): Bococizumab 75mg placebo

Answer: B