Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: AIEOP LLA 2000 Multicenter Study for the Diagnosis and Treatment of Childhood Acute Lymphoblastic Leukemia
Brief Summary: RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more effective in treating young patients with acute lymphoblastic leukemia.

PURPOSE: Thisphase III trial is studying several different combination chemotherapy regimens to compare how well they work in treating young patients with acute lymphoblastic leukemia.


Options:
A: Arm Label: PEG-asparaginase 6 weeks intervals; Type: EXPERIMENTAL; Interventions: Drug: PEG Asparaginase at six weeks interval | Arm Label: PEG-Asparaginase 2 weeks intervals; Type: ACTIVE_COMPARATOR; Interventions: Drug: PEG Asparaginase at two weeks interval | Intervention Type: DRUG; Name: PEG Asparaginase at six weeks interval; Assigned to Arm(s): PEG-asparaginase 6 weeks intervals | Intervention Type: DRUG; Name: PEG Asparaginase at two weeks interval; Assigned to Arm(s): PEG-Asparaginase 2 weeks intervals
B: Arm Label: Stratum I (radiotherapy, chemoprotective agent); Type: EXPERIMENTAL; Interventions: Drug: Amifostine, Other: Laboratory Biomarker Analysis, Radiation: Radiation Therapy | Arm Label: Stratum II (chemotherapy, chemoprotective agent, radiotherapy); Type: EXPERIMENTAL; Interventions: Drug: Amifostine, Drug: Cisplatin, Drug: Fluorouracil, Other: Laboratory Biomarker Analysis, Radiation: Radiation Therapy | Intervention Type: DRUG; Name: Amifostine; Assigned to Arm(s): Stratum I (radiotherapy, chemoprotective agent), Stratum II (chemotherapy, chemoprotective agent, radiotherapy) | Intervention Type: DRUG; Name: Cisplatin; Assigned to Arm(s): Stratum II (chemotherapy, chemoprotective agent, radiotherapy) | Intervention Type: DRUG; Name: Fluorouracil; Assigned to Arm(s): Stratum II (chemotherapy, chemoprotective agent, radiotherapy) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Stratum I (radiotherapy, chemoprotective agent), Stratum II (chemotherapy, chemoprotective agent, radiotherapy) | Intervention Type: RADIATION; Name: Radiation Therapy; Assigned to Arm(s): Stratum I (radiotherapy, chemoprotective agent), Stratum II (chemotherapy, chemoprotective agent, radiotherapy)
C: Arm Label: I; Type: EXPERIMENTAL; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: prednisone, Drug: Vincristine | Arm Label: II; Type: EXPERIMENTAL; Interventions: Drug: dexamethasone, Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: Vincristine | Arm Label: Reintensification Arm I; Type: EXPERIMENTAL; Interventions: Drug: Asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: doxorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: thioguanine, Drug: Vincristine | Arm Label: Reintensification Arm II; Type: EXPERIMENTAL; Interventions: Drug: Asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: doxorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: thioguanine, Drug: Vincristine | Arm Label: Reintensification Arm III; Type: EXPERIMENTAL; Interventions: Drug: Asparaginase, Drug: cytarabine, Drug: doxorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: Vincristine | Arm Label: Reintensification Arm IV; Type: EXPERIMENTAL; Interventions: Drug: Etoposide, Drug: Ifosfamide, Drug: Methotrexate, Drug: Vincristine, Drug: Vindesine | Arm Label: Reintensification Arm V; Type: EXPERIMENTAL; Interventions: Drug: Etoposide, Drug: Ifosfamide, Drug: Methotrexate, Drug: Vincristine, Drug: Vindesine | Intervention Type: DRUG; Name: dexamethasone; Assigned to Arm(s): II | Intervention Type: DRUG; Name: asparaginase; Assigned to Arm(s): I, II | Intervention Type: DRUG; Name: Asparaginase; Assigned to Arm(s): Reintensification Arm I, Reintensification Arm II, Reintensification Arm III | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II | Intervention Type: DRUG; Name: cytarabine; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II, Reintensification Arm III | Intervention Type: DRUG; Name: daunorubicin; Assigned to Arm(s): I, II | Intervention Type: DRUG; Name: doxorubicin; Assigned to Arm(s): Reintensification Arm I, Reintensification Arm II, Reintensification Arm III | Intervention Type: DRUG; Name: Etoposide; Assigned to Arm(s): Reintensification Arm IV, Reintensification Arm V | Intervention Type: DRUG; Name: Ifosfamide; Assigned to Arm(s): Reintensification Arm IV, Reintensification Arm V | Intervention Type: DRUG; Name: mercaptopurine; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II, Reintensification Arm III | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II, Reintensification Arm III, Reintensification Arm IV, Reintensification Arm V | Intervention Type: DRUG; Name: prednisone; Assigned to Arm(s): I | Intervention Type: DRUG; Name: thioguanine; Assigned to Arm(s): Reintensification Arm I, Reintensification Arm II | Intervention Type: DRUG; Name: Vincristine; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II, Reintensification Arm III, Reintensification Arm IV, Reintensification Arm V | Intervention Type: DRUG; Name: Vindesine; Assigned to Arm(s): Reintensification Arm IV, Reintensification Arm V
D: Arm Label: SC-PEG (Arm A); Type: ACTIVE_COMPARATOR; Interventions: Drug: SC-PEG | Arm Label: Oncaspar (Arm B); Type: ACTIVE_COMPARATOR; Interventions: Drug: Oncaspar | Intervention Type: DRUG; Name: SC-PEG; Assigned to Arm(s): SC-PEG (Arm A) | Intervention Type: DRUG; Name: Oncaspar; Assigned to Arm(s): Oncaspar (Arm B)

Answer: C