Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Two-Phase Randomized Controlled Clinical Trial of Buprenorphine/Naloxone Treatment Plus Standard Medical Management or Enhanced Medical Management for Opioid Analgesic Dependence
Brief Summary: The purpose of this study is to determine whether treatment outcome for subjects dependent on prescription opioid analgesics can be improved by adding individual drug counseling to the prescription of buprenorphine/naloxone with standard medical management. This will be examined during: a) an initial four-week treatment with taper; b) a 12-week stabilization treatment for those who do not respond successfully to the initial treatment; and c) a long-term follow-up assessment at 1.5 years, 2.5 years, and 3.5 years after treatment.


Options:
A: Arm Label: Buprenorphine/Nx; Type: EXPERIMENTAL; Interventions: Drug: Buprenorphine/naloxone | Arm Label: Methadone; Type: ACTIVE_COMPARATOR; Interventions: Drug: Methadone | Intervention Type: DRUG; Name: Buprenorphine/naloxone; Assigned to Arm(s): Buprenorphine/Nx | Intervention Type: DRUG; Name: Methadone; Assigned to Arm(s): Methadone
B: Arm Label: 1-week buprenorphine taper; Type: EXPERIMENTAL; Interventions: Drug: buprenorphine taper followed by naltrexone maintenance, Behavioral: Behavioral therapy | Arm Label: 2-week buprenorphine taper; Type: EXPERIMENTAL; Interventions: Drug: buprenorphine taper followed by naltrexone maintenance, Behavioral: Behavioral therapy | Arm Label: 4-week buprenorphine taper; Type: EXPERIMENTAL; Interventions: Drug: buprenorphine taper followed by naltrexone maintenance, Behavioral: Behavioral therapy | Intervention Type: DRUG; Name: buprenorphine taper followed by naltrexone maintenance; Assigned to Arm(s): 1-week buprenorphine taper, 2-week buprenorphine taper, 4-week buprenorphine taper | Intervention Type: BEHAVIORAL; Name: Behavioral therapy; Assigned to Arm(s): 1-week buprenorphine taper, 2-week buprenorphine taper, 4-week buprenorphine taper
C: Arm Label: Buprenorphine/Nx with EMM; Type: EXPERIMENTAL; Interventions: Behavioral: Enhanced Medical Management (EMM) of Prescription Opiate Abuse | Arm Label: Buprenorphine/Nx with SMM; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Standard Medical Management (SMM) of Prescription Opiate Abuse | Intervention Type: BEHAVIORAL; Name: Standard Medical Management (SMM) of Prescription Opiate Abuse; Assigned to Arm(s): Buprenorphine/Nx with SMM | Intervention Type: BEHAVIORAL; Name: Enhanced Medical Management (EMM) of Prescription Opiate Abuse; Assigned to Arm(s): Buprenorphine/Nx with EMM
D: Arm Label: Methadone Maintenance; Type: EXPERIMENTAL; Interventions: Drug: Methadone | Arm Label: Holistic Health Recovery Program; Type: EXPERIMENTAL; Interventions: Behavioral: Holistic Health Recovery Program | Arm Label: Methadone Maintenance and Holistic Health Recovery Prorgram; Type: EXPERIMENTAL; Interventions: Drug: Methadone, Behavioral: Holistic Health Recovery Program | Arm Label: Standard of Care; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DRUG; Name: Methadone; Assigned to Arm(s): Methadone Maintenance, Methadone Maintenance and Holistic Health Recovery Prorgram | Intervention Type: BEHAVIORAL; Name: Holistic Health Recovery Program; Assigned to Arm(s): Holistic Health Recovery Program, Methadone Maintenance and Holistic Health Recovery Prorgram

Answer: C