Please select the eligibility criteria that correspond to the clinical trial below.
Title: Intracytoplasmic Sperm Injection (ICSI) Versus Conventional in Vitro Fertilization (IVF) in Couples With Non-severe Male Infertility: a Randomized Controlled Trial
Brief Summary: A multicenter, parallel-controlled(1:1 treatment ratio), open-label, randomized clinical trials regarding fertilization and pregnancy outcomes between ICSI and conventional IVF among couples with no-severe male-factor infertility in China.


Options:
A: Inclusion Criteria:

* Infertile couples scheduled for their first or second IVF/ICSI cycle.
* Men with non-severe male infertility: Sperm concentration 5,000,000-15,000,000/ml or sperm with progressive motility (type A+B) 10-32%.
* Women received either gonadotrophin-releasing hormone agonist protocol or gonadotrophin-releasing hormone antagonist protocol as their controlled ovarian hyperstimulation treatment.
* Informed consent obtained.

Exclusion Criteria:

* Couple with contraindication for IVF or ICSI.
* Couples receiving donor sperm or donor eggs.
* Couples undergoing PGD and PGS.
* Sperm concentration with progressive motility used for insemination \<100,000/ml on the day of oocyte retrieval.
* Women with 0 oocytes after oocyte retrieval.
* Using frozen semen.
* Poor fertilization in previous cycle (≤ 25%).
B: Inclusion Criteria:

* Sperm parameters Sperm concentration before capacitation: \>15\*106 per ml (WHO) Total motility (PR+NP,%): \>40 (WHO) Progressive motility (PR,%):\>32 (WHO) Sperm concentration after capacitation: \>0.6\*106 per ml (not WHO defined) Progressive motility (PR,%):\>65 (WHO)
* ≥10 COCs after oocyte retrieval
* BMI ≤30 kg/m2
* Female age 18 to ≤ 40 years
* All ovarian stimulation protocols
* Fresh ejaculates
* Presence or absence of sperm morphology data: as the investigators do not have a diagnostic sperm analysis for all participants, the presence or absence of \>4% normal morphology (WHO) will not be taken into account, even with known low (\<4%) normal morphology
* Couples requesting PGT-A
* Arab population

Exclusion Criteria:

* If after denudation (ICSI) only 2 mature oocytes are obtained
* If all time lapse spaces are occupied
* If the volume to be added after IVF is insufficient to perform IVF on all needed oocytes
* Presence of \>1 \*106 per ml round cells in the ejaculate
* If a couple's previous cycle was included in the study
C: Inclusion Criteria:

* Women 18-42 years of age (both included) at the beginning of the ovarian stimulation
* BMI 18-35 kg/m2
* Indication for IVF due to tubal factor infertility, unexplained infertility, PCOS or light to moderate decreased semen quality
* Women treated with gonadotrophin in a standard short or long protocol and receiving ovulation trigger for oocyte pick up
* First treatment cycle for the couple
* Male partner with normal or non-severely decreased sperm parameters, where the sperm sample (purified) on the day of oocyte pick up is expected to contain a minimum of 2 million/mL progressive motile spermatozoa. Alternatively use of donorsperm.
* Willing to sign the informed consent

Exclusion Criteria:

* Ovarian cysts \>4 cm
* Known liver or kidney disease
* Previous IVF or ICSI treatment with current partner
* Use of donor oocytes or frozen oocytes
* Unregulated thyroid disease
* Endometriosis stage 3-4
* Hypogonadotropic hypogonadism
* Severe comorbidity (e.g. diabetes or cardiovascular disease)
* Not speaking / understanding Danish or English language
* Not willing to sign the informed consent
D: Inclusion Criteria:

* Having ≤ 2 IVF/ICSI cycles
* Total sperm count and motility are normal (WHO, 2010)
* Antagonist protocol
* Agree to have ≤ 2 embryos transferred
* Not participating in another IVF study at the same time

Exclusion Criteria:

* In-vitro maturation (IVM) cycles
* Using frozen semen
* Poor fertilization in previous cycle (≤ 25%)

Answer: A