Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Trial of a Positive Psychology Intervention to Reduce Suicide Risk in Patients With Major Depression
Brief Summary: In this study, the investigators will perform an exploratory randomized trial of Positive Psychology (PP). The trial will consist of 50 participants and will compare the impact of a phone-based PP intervention vs. an attentional control condition, in Major Depressive Disorder (MDD) patients who are hospitalized for SI or following a suicide attempt. This is a 12 week trial with 6 weeks of intervention and two blinded follow-up assessments at 6 and 12 weeks.

Specific Aim #1: To assess the feasibility and acceptability of the phone-based PP intervention in this high-risk population.

Hypotheses: The intervention will be feasible (with most patients completing at least 4/6 PP and with follow-up data from at least 80% of subjects). The ratings of ease and subjective helpfulness of the exercise and other mental states as measured before and after each PP exercise will be more than 6 out of 10 and higher than the same ratings obtained from subjects in the control condition.

Specific Aim #2: To examine the impact of the six-session PP intervention on positive psychological well-being.

Hypothesis: Compared to control subjects, subjects randomized to PP will have greater scores on scales of optimism (measured via the Life Orientation Test-Revised \[LOT-R\]), gratitude (Gratitude Questionnaire-6 \[GQ-6\]), and positive affect (Positive Affect Negative Affect Schedule \[PANAS\]) at 6 and 12 weeks.

Specific Aim #3 (primary aim): To assess the impact of the PP intervention on key suicide risk factors.

Hypothesis: PP subjects will have greater scores on scales of hopelessness (Beck Hopelessness Scale \[BHS\]; primary study outcome measure), suicidal ideation (SI) (Concise Health Risk Tracking scale \[CHRT\]), and depression (Quick Inventory of Depressive Symptomatology-Self Report \[QIDS-SR\]) at 6 and 12 weeks.

We will also measure impact on readmission and suicide attempts to assess these key outcomes.


Options:
A: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Drug: Lamotrigine | Arm Label: 2; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Lamotrigine; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): 2
B: Arm Label: Brief Cognitive Behavioral Therapy (BCBT); Type: EXPERIMENTAL; Interventions: Behavioral: Brief Cognitive Behavioral Therapy (BCBT) | Arm Label: Treatment As Usual (TAU); Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Treatment As Usual (TAU) | Intervention Type: BEHAVIORAL; Name: Brief Cognitive Behavioral Therapy (BCBT); Assigned to Arm(s): Brief Cognitive Behavioral Therapy (BCBT) | Intervention Type: BEHAVIORAL; Name: Treatment As Usual (TAU); Assigned to Arm(s): Treatment As Usual (TAU)
C: Arm Label: Peer Mentorship intervention; Type: EXPERIMENTAL; Interventions: Behavioral: Peer mentorship | Arm Label: Enhanced Usual Care (EUC); Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Enhanced Usual Care | Intervention Type: BEHAVIORAL; Name: Peer mentorship; Assigned to Arm(s): Peer Mentorship intervention | Intervention Type: BEHAVIORAL; Name: Enhanced Usual Care; Assigned to Arm(s): Enhanced Usual Care (EUC)
D: Arm Label: Positive Psychology; Type: EXPERIMENTAL; Interventions: Behavioral: Positive Psychology | Arm Label: Organizational Skills; Type: SHAM_COMPARATOR; Interventions: Behavioral: Control Condition | Intervention Type: BEHAVIORAL; Name: Positive Psychology; Assigned to Arm(s): Positive Psychology | Intervention Type: BEHAVIORAL; Name: Control Condition; Assigned to Arm(s): Organizational Skills

Answer: D