Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Multi-center, Randomized, Double-blind, Dose-ranging Study to Evaluate GSK573719 in Combination With Fluticasone Furoate, Fluticasone Furoate Alone, and an Active Control of Fluticasone Furoate/Vilanterol Combination in Subjects With Asthma
Brief Summary: Brief Summary: The purpose of this study is to characterize the dose response of GSK573719 in combination with Fluticasone furoate 100mcg in patients with asthma. Treatment with inhaled Fluticasone furoate and Fluticasone furoate/Vilanterol are included as an active control.

Detailed Description: Long acting muscarinic receptor antagonists (anti-cholinergic bronhcodilator) exert their effects via distinct and complementary bronchodilator mechanisms on large and small airways. Most of the experience with older anti-cholinergics had been with acute use and little is known about their effect in chronic use in asthma. This is a multicenter, randomized, double-blind, crossover study to evaluate 5 doses of inhaled GSK573719 inhaled over 14 days in patients with asthma. Fluticasone furoate (100 mcg) and Fluticasone furoate/Vilanterol (100/59mcg) will be included as an active comparator. Each eligible subject will receive a sequence of 3 of 7 potential treatments for a total of 3 treatment periods per subject. The total duration of subject participation is approximately 14 weeks.


Options:
A: Arm Label: Tiotropium daily dose q.d.; Type: EXPERIMENTAL; Interventions: Drug: Tiotropium 5 µg q.d. | Arm Label: Tiotropium half daily dose b.i.d.; Type: EXPERIMENTAL; Interventions: Drug: Tiotropium 2.5 µg b.i.d | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Tiotropium 2.5 µg b.i.d; Assigned to Arm(s): Tiotropium half daily dose b.i.d. | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: Tiotropium 5 µg q.d.; Assigned to Arm(s): Tiotropium daily dose q.d.
B: Arm Label: tiotropium low dose once daily; Type: EXPERIMENTAL; Interventions: Drug: tiotropium bromide 1.25µg once daily | Arm Label: tiotropium medium dose once daily; Type: EXPERIMENTAL; Interventions: Drug: tiotropium bromide 2.5µg once daily | Arm Label: tiotropium high dose once daily; Type: EXPERIMENTAL; Interventions: Drug: tiotropium bromide high dose once daily | Arm Label: Placebo once daily; Type: PLACEBO_COMPARATOR; Interventions: Drug: Tiotropium matching Placebo once daily | Intervention Type: DRUG; Name: tiotropium bromide 2.5µg once daily; Assigned to Arm(s): tiotropium medium dose once daily | Intervention Type: DRUG; Name: Tiotropium matching Placebo once daily; Assigned to Arm(s): Placebo once daily | Intervention Type: DRUG; Name: tiotropium bromide high dose once daily; Assigned to Arm(s): tiotropium high dose once daily | Intervention Type: DRUG; Name: tiotropium bromide 1.25µg once daily; Assigned to Arm(s): tiotropium low dose once daily
C: Arm Label: Fluticasone Furoate (FF); Type: ACTIVE_COMPARATOR; Interventions: Drug: FF | Arm Label: Fluticasone Furoate /Vilanterol (VI); Type: ACTIVE_COMPARATOR; Interventions: Drug: FF/VI | Arm Label: Fluticasone Furoate/GSK573719; Type: EXPERIMENTAL; Interventions: Drug: FF/GSK573719 | Intervention Type: DRUG; Name: FF/GSK573719; Assigned to Arm(s): Fluticasone Furoate/GSK573719 | Intervention Type: DRUG; Name: FF/GSK573719; Assigned to Arm(s): Fluticasone Furoate/GSK573719 | Intervention Type: DRUG; Name: FF/GSK573719; Assigned to Arm(s): Fluticasone Furoate/GSK573719 | Intervention Type: DRUG; Name: FF/GSK573719; Assigned to Arm(s): Fluticasone Furoate/GSK573719 | Intervention Type: DRUG; Name: FF/GSK573719; Assigned to Arm(s): Fluticasone Furoate/GSK573719 | Intervention Type: DRUG; Name: FF; Assigned to Arm(s): Fluticasone Furoate (FF) | Intervention Type: DRUG; Name: FF/VI; Assigned to Arm(s): Fluticasone Furoate /Vilanterol (VI)
D: Intervention Type: DRUG; Name: Tiotropium bromide; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: Salmeterol xinafoate; Assigned to Arm(s): N/A

Answer: C