Please select the eligibility criteria that correspond to the clinical trial below.
Title: Time Restricted Feeding for Weight Loss and Cardio-protection
Brief Summary: Time restricted feeding (TRF) is a novel form of intermittent fasting that involves confining the period of food intake to 8 h/d (e.g. 10 am to 6 pm) without calorie counting. TRF is effective for weight loss and cardio-protection in obese adults. It is of great interest to see whether subjects can adhere to TRF for longer periods of time, and to see what degree of weight loss that can be achieved with TRF. Accordingly, the aims of this trial are: Aim 1: To determine if TRF can be implemented to facilitate weight loss in obese adults, and Aim 2: To determine if TRF can produce clinically meaningful reductions in plasma lipids, blood pressure, insulin resistance, and inflammatory markers.


Options:
A: Inclusion Criteria:

1. The volunteer (male or non-pregnant female, any ethnicity) must be \>18 years of age.
2. The volunteer must either have a body mass index of 25.0-35.0 kg/m2 or the combination of a body mass index of 18.5-24.9 kg/m2 and two or more previously or currently measured symptoms of the metabolic syndrome (fasting glucose≥110 mg/dL, triglycerides≥150 mg/dL, high-density lipoprotein cholesterol\<40 mg/dL in males or \<50 mg/dL in females, systolic blood pressure≥130 mmHg or diastolic blood pressure≥85 mmHg, or waist circumference≥40 inches in males or ≥36 inches in females \[glucose and cholesterol levels may be self-reported\]).
3. The volunteer has not routinely participated in caloric restriction (deliberate limitation of caloric intake of \<80% than the FDA-recommended daily caloric intake) within the last 2 years, has not participated in extended fasting (\>12 hours at a time) for at least a year, and does not deliberately skip meals as a routine dietary practice.

Exclusion Criteria:

1. Body mass index \<18.5 or \>35 kg/m2.
2. Current active cancer treatment, treatment with immunosuppressive medications, or solid organ transplantation within 1 year.
3. Presence of immunosuppressive disease, myocardial infarction, peripheral vascular disease, or stroke within the past year.
4. Use of insulin.
5. Although it is unlikely fasting will harm the pregnant or lactating woman, the dietary restrictions placed on the participant for the duration of the study may conflict with dietary recommendations for pregnant or lactating women. Women of child bearing potential, therefore, will meet an exclusion if they become pregnant.
B: Inclusion Criteria:

* Male and female; body mass index (BMI) between 20-30 kg/m2;
* Age between 35-65 years; sedentary (light exercise less than 1h per week) or moderately active (1 to 2h per week);
* Weight stable for \>3 months prior to the beginning of the study;
* Able to give written informed consent;
* Female subjects must be post-menopausal for at least 2 years and can not be on hormone replacement therapy (HRT).

Exclusion Criteria:

* Diabetic;
* History of cardiovascular disease, i.e. myocardial infarction or stroke;
* History of cancer;
* Taking glucose lowering medication;
* Taking weight loss medication
C: Inclusion Criteria:

* Male or female
* Body mass index (BMI) between 30.0 and 40 kg/m2
* Age between 25 and 65 years
* Sedentary (light exercise less than 1 h per week) or moderately active (moderate exercise 1 to 2 h per week)
* Weight stable for \>3 months prior to the beginning of the study (gain or loss \<4 kg)
* Able to give written informed consent

Exclusion Criteria:

* Smoker
* Diabetic
* History of cardiovascular disease (myocardial infarction or stroke)
* Taking weight loss medications
* History of eating disorders
* Night-shift workers
* Perimenopausal
* Pregnant or trying to become pregnant
D: Inclusion Criteria:

* Female between 18 and 30 years of age
* Current university affiliation
* Weighing at least 110 pounds
* Generally healthy
* Resistance-trained
* Schedule availability to complete supervised resistance training
* Body fat percentage between 15 and 29%

Exclusion Criteria:

* Pregnant or trying to become pregnant
* Currently breastfeeding
* Any disease, condition or orthopedic limitation that would prevent safe participation in resistance training or time-restricted feeding
* Current smoker
* Presence of pacemaker or other electrical implant
* Allergic to dairy proteins

Answer: C