Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Mechanical Bowel Preparation for Elective Colorectal Surgery. A Multicenter Randomized Study
Brief Summary: Mechanical bowel preparation (MBP) is common practice in elective colorectal surgery. In recent literature the value of MBP is subject of discussion. We conducted a multicenter, randomized study with the goal of comparing outcome of elective colorectal resections and primary anastomoses with and without mechanical bowel preparation in terms of anastomotic leakage and other septic complications.

Within the setting of a multicenter randomized trial,1433 patients were randomized before elective colorectal surgery to receive either MBP or to have no MBP but a normal meal on the day before operation. The primary endpoint was anastomotic leakage. Secondary endpoints were septic complications (wound infection, urinary infection, pneumonia, pelvic abscesses), fascia dehiscence and death.

The incidence of anastomotic leakage was similar in both groups: 5.1% in patients without MBP versus 4.9% in patients with MBP (p=0.93; 95% confidence interval for the difference (no MBP minus MBP) ranges from -2.3% tot +2.7%). There were no significant differences in other septic complications, fascia dehiscence, or mortality. Fecal contamination, number of days until resumption of a normal diet, and duration of hospital stay were similar in both groups.

This study shows that elective colorectal surgery can be safely done without MBP. Therefore, MBP should be abandoned in elective colorectal surgery.


Options:
A: Arm Label: Mechanical Bowel Preparation and Oral Antibiotics; Type: EXPERIMENTAL; Interventions: Drug: Oral Antibiotics, Drug: Mechanical Bowel Preparation | Arm Label: Mechanical Bowel Preparation Only; Type: ACTIVE_COMPARATOR; Interventions: Drug: Placebo, Drug: Mechanical Bowel Preparation | Intervention Type: DRUG; Name: Oral Antibiotics; Assigned to Arm(s): Mechanical Bowel Preparation and Oral Antibiotics | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Mechanical Bowel Preparation Only | Intervention Type: DRUG; Name: Mechanical Bowel Preparation; Assigned to Arm(s): Mechanical Bowel Preparation Only, Mechanical Bowel Preparation and Oral Antibiotics
B: Intervention Type: DRUG; Name: polyethylene glycol bowel lavage solution; Assigned to Arm(s): N/A
C: Arm Label: Oral Antibiotics; Type: N/A; Interventions: Drug: Paromomycin Sulfate Powder | Arm Label: iv Antibiotics; Type: N/A; Interventions: N/A | Intervention Type: DRUG; Name: Paromomycin Sulfate Powder; Assigned to Arm(s): Oral Antibiotics
D: Arm Label: Oral with Intravenous; Type: EXPERIMENTAL; Interventions: Drug: Oral antibiotic, Drug: Intravenous antibiotic, Drug: Mechanical Bowel Preparation | Arm Label: Intravenous; Type: ACTIVE_COMPARATOR; Interventions: Drug: Intravenous antibiotic, Drug: Mechanical Bowel Preparation | Intervention Type: DRUG; Name: Oral antibiotic; Assigned to Arm(s): Oral with Intravenous | Intervention Type: DRUG; Name: Intravenous antibiotic; Assigned to Arm(s): Intravenous, Oral with Intravenous | Intervention Type: DRUG; Name: Mechanical Bowel Preparation; Assigned to Arm(s): Intravenous, Oral with Intravenous

Answer: B