Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: The ProtecT Trial - Evaluating the Effectiveness of Treatments for Clinically Localised Prostate Cancer
Brief Summary: RATIONALE: Radical prostatectomy is surgery to remove the entire prostate. Radiation therapy uses high-energy x-rays or other types of radiation to kill tumor cells. Sometimes the tumor may not need treatment until it progresses. In this case, active surveillance may be sufficient. It is not yet known which treatment regimen is more effective for localized prostate cancer.

PURPOSE: This randomized phase III trial is studying active monitoring to see how well it works compared with radical prostatectomy or radiation therapy in treating patients with localized prostate cancer.


Options:
A: Arm Label: Placebo + prednisone; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Drug: Prednisone | Arm Label: Abiraterone + prednisone; Type: EXPERIMENTAL; Interventions: Drug: Abiraterone acetate, Drug: Prednisone | Intervention Type: DRUG; Name: Abiraterone acetate; Assigned to Arm(s): Abiraterone + prednisone | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo + prednisone | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): Abiraterone + prednisone, Placebo + prednisone
B: Arm Label: Radical prostatectomy; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Radical prostatectomy | Arm Label: Conformal radiation therapy; Type: ACTIVE_COMPARATOR; Interventions: Radiation: Conformal radiation therapy | Arm Label: Active monitoring; Type: ACTIVE_COMPARATOR; Interventions: Other: Active monitoring | Intervention Type: PROCEDURE; Name: Radical prostatectomy; Assigned to Arm(s): Radical prostatectomy | Intervention Type: RADIATION; Name: Conformal radiation therapy; Assigned to Arm(s): Conformal radiation therapy | Intervention Type: OTHER; Name: Active monitoring; Assigned to Arm(s): Active monitoring
C: Arm Label: Arm A; Type: ACTIVE_COMPARATOR; Interventions: Other: Androgen Deprivation Therapy, Drug: Docetaxel | Arm Label: Arm B; Type: EXPERIMENTAL; Interventions: Drug: abiraterone acetate, Other: Androgen Deprivation Therapy, Drug: Docetaxel | Arm Label: Arm C; Type: EXPERIMENTAL; Interventions: Radiation: radiotherapy, Other: Androgen Deprivation Therapy, Drug: Docetaxel | Arm Label: Arm D; Type: EXPERIMENTAL; Interventions: Drug: abiraterone acetate, Radiation: radiotherapy, Other: Androgen Deprivation Therapy, Drug: Docetaxel | Intervention Type: DRUG; Name: abiraterone acetate; Assigned to Arm(s): Arm B, Arm D | Intervention Type: RADIATION; Name: radiotherapy; Assigned to Arm(s): Arm C, Arm D | Intervention Type: OTHER; Name: Androgen Deprivation Therapy; Assigned to Arm(s): Arm A, Arm B, Arm C, Arm D | Intervention Type: DRUG; Name: Docetaxel; Assigned to Arm(s): Arm A, Arm B, Arm C, Arm D
D: Arm Label: Abiraterone acetate plus prednisone/prednisolone; Type: EXPERIMENTAL; Interventions: Drug: Abiraterone acetate, Drug: Prednisone/prednisolone | Arm Label: Placebo plus prednisone/prednisolone; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Drug: Prednisone/prednisolone | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo plus prednisone/prednisolone | Intervention Type: DRUG; Name: Abiraterone acetate; Assigned to Arm(s): Abiraterone acetate plus prednisone/prednisolone | Intervention Type: DRUG; Name: Prednisone/prednisolone; Assigned to Arm(s): Abiraterone acetate plus prednisone/prednisolone, Placebo plus prednisone/prednisolone

Answer: B