Please select the eligibility criteria that correspond to the clinical trial below.
Title: Cognitive Training to Enhance VA Work Program Outcomes
Brief Summary: The purpose of this study is to determine whether augmenting work services with cognitive remediation can improve vocational outcomes for psychiatrically disabled participants in VA work services.


Options:
A: Inclusion Criteria:

* verified (Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, SCID) diagnosis of schizophrenia spectrum disorder
* outpatient in treatment
* written informed consent
* fluent in a Scandinavian language

Exclusion Criteria:

* chest pain during exercise
* unstable angina pectoris
* suspicion of recent myocardial infarction
* uncontrollable arrhythmia
* acute infection with lymphadenopathy
* malignant hypertension
* neurological disorder
* severe physical disability
* medical condition incompatible with particiption
* comorbid diagnosis of mild mental retardation
* pregnancy
B: Inclusion Criteria:

1. Subjects must be between 18 and 65 years old, inclusive, at the time of study screening
2. Subjects must have a diagnosis of schizophrenia as defined by an interview.
3. Subjects must demonstrate adequate decisional capacity, in the judgment of the consenting study staff member, to make a choice about participating in this research study.
4. Subjects must have been clinically stable (non-acute) for 8 weeks prior to consent; in the judgment of the Site Principal Investigator.
5. Subjects must have been maintained on a stable treatment of antipsychotics and/or other concomitant psychotropic treatment for at least 6 weeks prior to consent.
6. Subjects must have learned English before the age of 12 to ensure valid neuropsychological results.
7. Subjects must have the visual, auditory, and motor capacity to use the computerized intervention in the judgment of the consenting study staff person.
8. Subjects must have no more than a moderately severe rating on hallucinations and unusual thought content.

Exclusion Criteria:

1. Subjects should not have had a psychiatric hospitalization in the 8 weeks prior to consent.
2. Subjects who appear to be intoxicated or under the influence of a controlled substance on any day of assessment must be rescheduled or discontinued based upon the discretion of the site staff evaluator.
3. Subjects should not have a history of mental retardation or pervasive developmental disorder; or other neurological disorder (e.g., Traumatic Brain Injury, epilepsy, Parkinson's Disease.)
4. Subjects should not have been treated within 3 years of the date of consent with a computer-based cognitive training program manufactured by Posit Science.
5. Subjects should not be participating in a concurrent clinical trial that, in the judgment of the Site Principal Investigator, could affect the outcome of this one.
6. Subjects must not show suicidal ideation or behaviors.
C: Inclusion Criteria:

* Participant in VA work services
* Chronic and disabling psychiatric illness

Exclusion Criteria:

* Neurological Disease that may affect cognition
* Primary substance abuse
* Developmental Disability
D: Inclusion Criteria:

* Males and females between ages 18-55.
* Have capacity to give informed consent.
* English speaking.
* Have a DSM-IV diagnosis of schizophrenia.
* Taking antipsychotic medication for at least 8 weeks and on current doses for 4 weeks, and/or injectable depot antipsychotics with no change in last 3 months.
* Medically cleared to exercise.

Exclusion Criteria:

* Lacks capacity to give informed consent.
* Have used street drugs within the past 4 weeks.
* Have history of of hypertension of cardiac conditions.
* Have history of active suicidal ideation or serious self-destructive behavior.
* Have history of violence or aggressive behavior.
* Have history of neurological or medical conditions known to seriously affect the brain.
* Pregnant or nursing.
* Completing more than 2 hours of moderate or higher levels of aerobic exercise per week.
* Participation in a study of cognition during the previous 2 months.

Answer: C