Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: ALL-BFM 2000 Multi-Center Study for the Treatment of Children and Adolescents With Acute Lymphoblastic Leukemia
Brief Summary: RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more effective in treating young patients with acute lymphoblastic leukemia.

PURPOSE: Thisphase III trial is studying several different combination chemotherapy regimens to compare how well they work in treating young patients with acute lymphoblastic leukemia.


Options:
A: Arm Label: Induction Prot I/Dexa - reinduction Prot III; Type: EXPERIMENTAL; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin hydrochloride, Drug: dexamethasone, Drug: doxorubicin hydrochloride, Drug: ifosfamide, Drug: mercaptopurine, Drug: methotrexate, Drug: prednisone, Drug: thioguanine, Drug: vincristine sulfate, Drug: vindesine, Radiation: radiation therapy | Arm Label: Induction Prot I/Pred - reinduction Prot III; Type: EXPERIMENTAL; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin hydrochloride, Drug: dexamethasone, Drug: doxorubicin hydrochloride, Drug: ifosfamide, Drug: mercaptopurine, Drug: methotrexate, Drug: prednisone, Drug: thioguanine, Drug: vincristine sulfate, Drug: vindesine, Radiation: radiation therapy | Arm Label: Induction Prot I/Dexa - reinduction Prot II; Type: EXPERIMENTAL; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin hydrochloride, Drug: dexamethasone, Drug: doxorubicin hydrochloride, Drug: ifosfamide, Drug: mercaptopurine, Drug: methotrexate, Drug: prednisone, Drug: thioguanine, Drug: vincristine sulfate, Drug: vindesine, Radiation: radiation therapy | Arm Label: Induction Prot I/Pred - reinduction Prot II; Type: ACTIVE_COMPARATOR; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin hydrochloride, Drug: dexamethasone, Drug: doxorubicin hydrochloride, Drug: ifosfamide, Drug: mercaptopurine, Drug: methotrexate, Drug: prednisone, Drug: thioguanine, Drug: vincristine sulfate, Drug: vindesine, Radiation: radiation therapy | Arm Label: Induction Prot I/Dexa - reinduction 2x Prot III; Type: EXPERIMENTAL; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin hydrochloride, Drug: dexamethasone, Drug: doxorubicin hydrochloride, Drug: ifosfamide, Drug: mercaptopurine, Drug: methotrexate, Drug: prednisone, Drug: thioguanine, Drug: vincristine sulfate, Drug: vindesine, Radiation: radiation therapy | Arm Label: Induction Prot I/Pred - reinduction 2x Prot III; Type: EXPERIMENTAL; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin hydrochloride, Drug: dexamethasone, Drug: doxorubicin hydrochloride, Drug: ifosfamide, Drug: mercaptopurine, Drug: methotrexate, Drug: prednisone, Drug: thioguanine, Drug: vincristine sulfate, Drug: vindesine, Radiation: radiation therapy | Arm Label: Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III; Type: EXPERIMENTAL; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin hydrochloride, Drug: dexamethasone, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: ifosfamide, Drug: mercaptopurine, Drug: methotrexate, Drug: prednisone, Drug: thioguanine, Drug: vincristine sulfate, Drug: vindesine, Radiation: radiation therapy | Arm Label: Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III; Type: EXPERIMENTAL; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin hydrochloride, Drug: dexamethasone, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: ifosfamide, Drug: mercaptopurine, Drug: methotrexate, Drug: prednisone, Drug: thioguanine, Drug: vincristine sulfate, Drug: vindesine, Radiation: radiation therapy | Arm Label: Induction Prot I/Dexa - reinduction 6 HR courses + Prot II; Type: EXPERIMENTAL; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin hydrochloride, Drug: dexamethasone, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: ifosfamide, Drug: mercaptopurine, Drug: methotrexate, Drug: prednisone, Drug: thioguanine, Drug: vincristine sulfate, Drug: vindesine, Radiation: radiation therapy | Arm Label: Induction Prot I/Pred - reinduction 6 HR courses + Prot II; Type: ACTIVE_COMPARATOR; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin hydrochloride, Drug: dexamethasone, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: ifosfamide, Drug: mercaptopurine, Drug: methotrexate, Drug: prednisone, Drug: thioguanine, Drug: vincristine sulfate, Drug: vindesine, Radiation: radiation therapy | Intervention Type: DRUG; Name: asparaginase; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 2x Prot III, Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Dexa - reinduction Prot II, Induction Prot I/Dexa - reinduction Prot III, Induction Prot I/Pred - reinduction 2x Prot III, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction Prot II, Induction Prot I/Pred - reinduction Prot III | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 2x Prot III, Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Dexa - reinduction Prot II, Induction Prot I/Dexa - reinduction Prot III, Induction Prot I/Pred - reinduction 2x Prot III, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction Prot II, Induction Prot I/Pred - reinduction Prot III | Intervention Type: DRUG; Name: cytarabine; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 2x Prot III, Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Dexa - reinduction Prot II, Induction Prot I/Dexa - reinduction Prot III, Induction Prot I/Pred - reinduction 2x Prot III, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction Prot II, Induction Prot I/Pred - reinduction Prot III | Intervention Type: DRUG; Name: daunorubicin hydrochloride; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 2x Prot III, Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Dexa - reinduction Prot II, Induction Prot I/Dexa - reinduction Prot III, Induction Prot I/Pred - reinduction 2x Prot III, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction Prot II, Induction Prot I/Pred - reinduction Prot III | Intervention Type: DRUG; Name: dexamethasone; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 2x Prot III, Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Dexa - reinduction Prot II, Induction Prot I/Dexa - reinduction Prot III, Induction Prot I/Pred - reinduction 2x Prot III, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction Prot II, Induction Prot I/Pred - reinduction Prot III | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 2x Prot III, Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Dexa - reinduction Prot II, Induction Prot I/Dexa - reinduction Prot III, Induction Prot I/Pred - reinduction 2x Prot III, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction Prot II, Induction Prot I/Pred - reinduction Prot III | Intervention Type: DRUG; Name: etoposide; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II | Intervention Type: DRUG; Name: ifosfamide; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 2x Prot III, Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Dexa - reinduction Prot II, Induction Prot I/Dexa - reinduction Prot III, Induction Prot I/Pred - reinduction 2x Prot III, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction Prot II, Induction Prot I/Pred - reinduction Prot III | Intervention Type: DRUG; Name: mercaptopurine; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 2x Prot III, Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Dexa - reinduction Prot II, Induction Prot I/Dexa - reinduction Prot III, Induction Prot I/Pred - reinduction 2x Prot III, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction Prot II, Induction Prot I/Pred - reinduction Prot III | Intervention Type: DRUG; Name: methotrexate; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 2x Prot III, Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Dexa - reinduction Prot II, Induction Prot I/Dexa - reinduction Prot III, Induction Prot I/Pred - reinduction 2x Prot III, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction Prot II, Induction Prot I/Pred - reinduction Prot III | Intervention Type: DRUG; Name: prednisone; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 2x Prot III, Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Dexa - reinduction Prot II, Induction Prot I/Dexa - reinduction Prot III, Induction Prot I/Pred - reinduction 2x Prot III, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction Prot II, Induction Prot I/Pred - reinduction Prot III | Intervention Type: DRUG; Name: thioguanine; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 2x Prot III, Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Dexa - reinduction Prot II, Induction Prot I/Dexa - reinduction Prot III, Induction Prot I/Pred - reinduction 2x Prot III, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction Prot II, Induction Prot I/Pred - reinduction Prot III | Intervention Type: DRUG; Name: vincristine sulfate; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 2x Prot III, Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Dexa - reinduction Prot II, Induction Prot I/Dexa - reinduction Prot III, Induction Prot I/Pred - reinduction 2x Prot III, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction Prot II, Induction Prot I/Pred - reinduction Prot III | Intervention Type: DRUG; Name: vindesine; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 2x Prot III, Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Dexa - reinduction Prot II, Induction Prot I/Dexa - reinduction Prot III, Induction Prot I/Pred - reinduction 2x Prot III, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction Prot II, Induction Prot I/Pred - reinduction Prot III | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): Induction Prot I/Dexa - reinduction 2x Prot III, Induction Prot I/Dexa - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Dexa - reinduction 6 HR courses + Prot II, Induction Prot I/Dexa - reinduction Prot II, Induction Prot I/Dexa - reinduction Prot III, Induction Prot I/Pred - reinduction 2x Prot III, Induction Prot I/Pred - reinduction 3 HR courses + 3x Prot III, Induction Prot I/Pred - reinduction 6 HR courses + Prot II, Induction Prot I/Pred - reinduction Prot II, Induction Prot I/Pred - reinduction Prot III
B: Arm Label: asparaginase medac; Type: ACTIVE_COMPARATOR; Interventions: Drug: asparaginase | Arm Label: recombinant asparaginase; Type: EXPERIMENTAL; Interventions: Drug: recombinant asparaginase | Intervention Type: DRUG; Name: asparaginase; Assigned to Arm(s): asparaginase medac | Intervention Type: DRUG; Name: recombinant asparaginase; Assigned to Arm(s): recombinant asparaginase
C: Arm Label: Stratum I (radiotherapy, chemoprotective agent); Type: EXPERIMENTAL; Interventions: Drug: Amifostine, Other: Laboratory Biomarker Analysis, Radiation: Radiation Therapy | Arm Label: Stratum II (chemotherapy, chemoprotective agent, radiotherapy); Type: EXPERIMENTAL; Interventions: Drug: Amifostine, Drug: Cisplatin, Drug: Fluorouracil, Other: Laboratory Biomarker Analysis, Radiation: Radiation Therapy | Intervention Type: DRUG; Name: Amifostine; Assigned to Arm(s): Stratum I (radiotherapy, chemoprotective agent), Stratum II (chemotherapy, chemoprotective agent, radiotherapy) | Intervention Type: DRUG; Name: Cisplatin; Assigned to Arm(s): Stratum II (chemotherapy, chemoprotective agent, radiotherapy) | Intervention Type: DRUG; Name: Fluorouracil; Assigned to Arm(s): Stratum II (chemotherapy, chemoprotective agent, radiotherapy) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Stratum I (radiotherapy, chemoprotective agent), Stratum II (chemotherapy, chemoprotective agent, radiotherapy) | Intervention Type: RADIATION; Name: Radiation Therapy; Assigned to Arm(s): Stratum I (radiotherapy, chemoprotective agent), Stratum II (chemotherapy, chemoprotective agent, radiotherapy)
D: Arm Label: I; Type: EXPERIMENTAL; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: prednisone, Drug: Vincristine | Arm Label: II; Type: EXPERIMENTAL; Interventions: Drug: dexamethasone, Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: daunorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: Vincristine | Arm Label: Reintensification Arm I; Type: EXPERIMENTAL; Interventions: Drug: Asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: doxorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: thioguanine, Drug: Vincristine | Arm Label: Reintensification Arm II; Type: EXPERIMENTAL; Interventions: Drug: Asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: doxorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: thioguanine, Drug: Vincristine | Arm Label: Reintensification Arm III; Type: EXPERIMENTAL; Interventions: Drug: Asparaginase, Drug: cytarabine, Drug: doxorubicin, Drug: mercaptopurine, Drug: Methotrexate, Drug: Vincristine | Arm Label: Reintensification Arm IV; Type: EXPERIMENTAL; Interventions: Drug: Etoposide, Drug: Ifosfamide, Drug: Methotrexate, Drug: Vincristine, Drug: Vindesine | Arm Label: Reintensification Arm V; Type: EXPERIMENTAL; Interventions: Drug: Etoposide, Drug: Ifosfamide, Drug: Methotrexate, Drug: Vincristine, Drug: Vindesine | Intervention Type: DRUG; Name: dexamethasone; Assigned to Arm(s): II | Intervention Type: DRUG; Name: asparaginase; Assigned to Arm(s): I, II | Intervention Type: DRUG; Name: Asparaginase; Assigned to Arm(s): Reintensification Arm I, Reintensification Arm II, Reintensification Arm III | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II | Intervention Type: DRUG; Name: cytarabine; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II, Reintensification Arm III | Intervention Type: DRUG; Name: daunorubicin; Assigned to Arm(s): I, II | Intervention Type: DRUG; Name: doxorubicin; Assigned to Arm(s): Reintensification Arm I, Reintensification Arm II, Reintensification Arm III | Intervention Type: DRUG; Name: Etoposide; Assigned to Arm(s): Reintensification Arm IV, Reintensification Arm V | Intervention Type: DRUG; Name: Ifosfamide; Assigned to Arm(s): Reintensification Arm IV, Reintensification Arm V | Intervention Type: DRUG; Name: mercaptopurine; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II, Reintensification Arm III | Intervention Type: DRUG; Name: Methotrexate; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II, Reintensification Arm III, Reintensification Arm IV, Reintensification Arm V | Intervention Type: DRUG; Name: prednisone; Assigned to Arm(s): I | Intervention Type: DRUG; Name: thioguanine; Assigned to Arm(s): Reintensification Arm I, Reintensification Arm II | Intervention Type: DRUG; Name: Vincristine; Assigned to Arm(s): I, II, Reintensification Arm I, Reintensification Arm II, Reintensification Arm III, Reintensification Arm IV, Reintensification Arm V | Intervention Type: DRUG; Name: Vindesine; Assigned to Arm(s): Reintensification Arm IV, Reintensification Arm V

Answer: A