Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, 32 Week Double-blind, Parallel-group, Multicenter Study to Compare the Efficacy and Safety of Initiating Treatment With Combination (Aliskiren/Amlodipine) Therapy in Comparison With the Sequential add-on Treatment Strategies in Patients With Essential Hypertension
Brief Summary: This study will compare the safety and efficacy of initial combination treatment with aliskiren + amlodipine to sequential add-on treatment strategies with aliskiren or amlodipine in patients with hypertension.


Options:
A: Arm Label: Benazepril/amlodipine; Type: EXPERIMENTAL; Interventions: Drug: Benazepril/amlodipine 20/5 mg - Dose Level 1 from Day 1 to Month 1, Drug: Benazepril/amlodipine 40/5 mg - Dose Level 2 from Month 1 to Month 2, Drug: Benazepril/amlodipine 40/10 mg - Dose Level 3 from Month 2 to Month 3 and thereafter | Arm Label: Benazepril/hydrochlorothiazide; Type: ACTIVE_COMPARATOR; Interventions: Drug: Benazepril/hydrochlorothiazide 20/12.5 mg - Dose Level 1 from Day 1 to Month 1, Drug: Benazepril/hydrochlorothiazide 40/12.5 mg - Dose Level 2 from Month 1 to Month 2, Drug: Benazepril/hydrochlorothiazide 40/25 mg - Dose Level 3 from Month 2 to Month 3 and thereafter | Intervention Type: DRUG; Name: Benazepril/amlodipine 20/5 mg - Dose Level 1 from Day 1 to Month 1; Assigned to Arm(s): Benazepril/amlodipine | Intervention Type: DRUG; Name: Benazepril/amlodipine 40/5 mg - Dose Level 2 from Month 1 to Month 2; Assigned to Arm(s): Benazepril/amlodipine | Intervention Type: DRUG; Name: Benazepril/amlodipine 40/10 mg - Dose Level 3 from Month 2 to Month 3 and thereafter; Assigned to Arm(s): Benazepril/amlodipine | Intervention Type: DRUG; Name: Benazepril/hydrochlorothiazide 20/12.5 mg - Dose Level 1 from Day 1 to Month 1; Assigned to Arm(s): Benazepril/hydrochlorothiazide | Intervention Type: DRUG; Name: Benazepril/hydrochlorothiazide 40/12.5 mg - Dose Level 2 from Month 1 to Month 2; Assigned to Arm(s): Benazepril/hydrochlorothiazide | Intervention Type: DRUG; Name: Benazepril/hydrochlorothiazide 40/25 mg - Dose Level 3 from Month 2 to Month 3 and thereafter; Assigned to Arm(s): Benazepril/hydrochlorothiazide
B: Arm Label: A-1, B-1; Type: ACTIVE_COMPARATOR; Interventions: Drug: trandolapril | Arm Label: A-2, B-2; Type: ACTIVE_COMPARATOR; Interventions: Drug: trandolapril/verapamil | Arm Label: A-3; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo | Arm Label: A-4; Type: ACTIVE_COMPARATOR; Interventions: Drug: verapamil | Intervention Type: DRUG; Name: trandolapril; Assigned to Arm(s): A-1, B-1 | Intervention Type: DRUG; Name: trandolapril/verapamil; Assigned to Arm(s): A-2, B-2 | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): A-3 | Intervention Type: DRUG; Name: verapamil; Assigned to Arm(s): A-4
C: Arm Label: Combination Therapy; Type: EXPERIMENTAL; Interventions: Drug: Losartan and hydrochlorothiazide | Arm Label: Monotherapy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Hydrochlorothiazide switched over with Losartan at 8 weeks | Intervention Type: DRUG; Name: Losartan and hydrochlorothiazide; Assigned to Arm(s): Combination Therapy | Intervention Type: DRUG; Name: Hydrochlorothiazide switched over with Losartan at 8 weeks; Assigned to Arm(s): Monotherapy
D: Arm Label: Aliskiren + Amlodipine; Type: EXPERIMENTAL; Interventions: Drug: Amlodipine, Drug: hydrochlorothiazide, Drug: Aliskiren | Arm Label: Aliskiren Start - Amlodipine Add-On; Type: EXPERIMENTAL; Interventions: Drug: Amlodipine, Drug: hydrochlorothiazide, Drug: Aliskiren | Arm Label: Amlodipine Start- Aliskiren Add-On; Type: EXPERIMENTAL; Interventions: Drug: Amlodipine, Drug: hydrochlorothiazide, Drug: Aliskiren | Intervention Type: DRUG; Name: Amlodipine; Assigned to Arm(s): Aliskiren + Amlodipine, Aliskiren Start - Amlodipine Add-On, Amlodipine Start- Aliskiren Add-On | Intervention Type: DRUG; Name: hydrochlorothiazide; Assigned to Arm(s): Aliskiren + Amlodipine, Aliskiren Start - Amlodipine Add-On, Amlodipine Start- Aliskiren Add-On | Intervention Type: DRUG; Name: Aliskiren; Assigned to Arm(s): Aliskiren + Amlodipine, Aliskiren Start - Amlodipine Add-On, Amlodipine Start- Aliskiren Add-On

Answer: D