Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized Controlled Trial of Live Attenuated Vaccine Versus Trivalent Inactivated Vaccine in Hutterite Children
Brief Summary: There is uncertainty about whether a live attenuated vaccine (LAIV) offers additional benefit over inactivated trivalent influenza vaccine (TIV) in providing indirect benefit to those who are unvaccinated through herd immunity. The goal of this randomized clinical trial is to determine whether immunizing children in Hutterite colonies with LAIV can provide increased community-wide protection over TIV. Children aged 3 to 15 years in Hutterite colonies from Alberta and Saskatchewan will be randomized to one of two regimens: TIV or LAIV. The primary outcome of this study will be laboratory-confirmed influenza as detected by PCR in all participants (i.e vaccine recipients and nonrecipients). Secondary outcomes will include influenza-like illness, hospitalization, pneumonia, death, antibiotic use, absenteeism.


Options:
A: Arm Label: Influenza vaccine LAIV; Type: EXPERIMENTAL; Interventions: Biological: Trivalent Inactivated Vaccine | Arm Label: Influenza vaccine TIV; Type: ACTIVE_COMPARATOR; Interventions: Biological: Live Attenuated Influenza Vaccine | Intervention Type: BIOLOGICAL; Name: Trivalent Inactivated Vaccine; Assigned to Arm(s): Influenza vaccine LAIV | Intervention Type: BIOLOGICAL; Name: Live Attenuated Influenza Vaccine; Assigned to Arm(s): Influenza vaccine TIV
B: Intervention Type: BIOLOGICAL; Name: CAIV-T; Assigned to Arm(s): N/A
C: Arm Label: TIV-adj; Type: EXPERIMENTAL; Interventions: Biological: Adjuvanted trivalent inactivated subunit influenza vaccine | Arm Label: Flu-control; Type: ACTIVE_COMPARATOR; Interventions: Biological: Non-adjuvanted trivalent inactivated subunit influenza vaccine or non-adjuvanted trivalent inactivated split influenza vaccine | Arm Label: Non-flu Control; Type: SHAM_COMPARATOR; Interventions: Biological: Meningococcal C conjugate vaccine or tick-borne encephalitis vaccine | Intervention Type: BIOLOGICAL; Name: Adjuvanted trivalent inactivated subunit influenza vaccine; Assigned to Arm(s): TIV-adj | Intervention Type: BIOLOGICAL; Name: Non-adjuvanted trivalent inactivated subunit influenza vaccine or non-adjuvanted trivalent inactivated split influenza vaccine; Assigned to Arm(s): Flu-control | Intervention Type: BIOLOGICAL; Name: Meningococcal C conjugate vaccine or tick-borne encephalitis vaccine; Assigned to Arm(s): Non-flu Control
D: Arm Label: Afluria Cohort A; Type: EXPERIMENTAL; Interventions: Biological: CSL's Influenza Virus Vaccine (Afluria) | Arm Label: Afluria Cohort B; Type: EXPERIMENTAL; Interventions: Biological: CSL's Influenza Virus Vaccine (Afluria) | Arm Label: Afluria Cohort C; Type: EXPERIMENTAL; Interventions: Biological: CSL's Influenza Virus Vaccine (Afluria) | Arm Label: Fluzone Cohort A; Type: ACTIVE_COMPARATOR; Interventions: Biological: Influenza Virus Vaccine (Fluzone) | Arm Label: Fluzone Cohort B; Type: ACTIVE_COMPARATOR; Interventions: Biological: Influenza Virus Vaccine (Fluzone) | Arm Label: Fluzone Cohort C; Type: ACTIVE_COMPARATOR; Interventions: Biological: Influenza Virus Vaccine (Fluzone) | Intervention Type: BIOLOGICAL; Name: CSL's Influenza Virus Vaccine (Afluria); Assigned to Arm(s): Afluria Cohort A, Afluria Cohort B, Afluria Cohort C | Intervention Type: BIOLOGICAL; Name: Influenza Virus Vaccine (Fluzone); Assigned to Arm(s): Fluzone Cohort A, Fluzone Cohort B, Fluzone Cohort C

Answer: A