Please select the eligibility criteria that correspond to the clinical trial below.
Title: Randomised Controlled Trial of Percutaneous Transluminal Angioplasty (PTA) Versus a Supervised Exercise Programme (SEP) in the Management of Intermittent Claudication (IC) Due to Femoro-popliteal Disease
Brief Summary: Intermittent Claudication (IC)is a common condition characterised by pain in the muscles of the legs on exertion caused by "hardening of the arteries" and a reduced blood supply. The investigators know that the vast majority of people suffering from this condition remain stable and do not deteriorate, and thus in general the viability of legs is not at risk. The main aim of treatment, therefore, is to try and improve walking thus reducing the impact this problem has on patients life style. There are many methods of management of intermittent claudication, but the investigators do not know which produces the best results. This study aims to compare the short and medium term outcomes of exercise programmes, percutaneous transluminal angioplasty and a combination of the two treatments for patients with intermittent claudication.


Options:
A: Inclusion Criteria:

* PAD stage 2 or 3 according to Fontaine,
* Surgical or radiological intervention indicated

Exclusion Criteria:

* No insurance for physiotherapy,
* Insufficient command of the Dutch language,
* Serious cardiopulmonary limitations (NYHA 3-4,)
* Major amputation,
* Serious co-morbidity prohibiting physical training
B: Inclusion Criteria:

* Men and women ages 70 to 89
* Residency in the area for at least 9 months in the next year
* Summary score of under 10 on the Established Populations for Epidemiologic Studies of the Elderly (EPESE) physical performance battery; ability to complete the 400 m walk test within 15 minutes without sitting and without the use of an assistive device (including a cane) or the help of another person
* Able to understand and perform the required study procedures; no diagnosis of dementia
* Sedentary lifestyle, i.e., has spent less than 20 minutes per week in the past month getting regular physical activity
* Willing to give informed consent, willing to be randomized to either intervention, and to follow the protocol for the group to which they have been assigned
* Successful completion of the behavioral run-in

Exclusion Criteria:

* Potential difficulty adhering to either intervention
* Unable or unwilling to give informed consent or accept randomization
* Participation may be unsafe
* Serious health conditions that would interfere with the intervention goals
* Already physically active to a degree that the adoption of an activity program would be of little additional benefit
* Self-reported inability to walk two blocks
* Use of walker or assistive device to complete the 400 m walk
C: Inclusion Criteria:

* Symptomatic unilateral Intermittent Claudication Femoro-popliteal lesion Angioplastiable lesion on duplex \> 3 months on BMT

Exclusion Criteria:

* Critical ischaemia Incapacitating systemic disease Inability to tolerate treadmill testing Ischaemic changes on ECG during treadmill testing Ipsilateral surgery / PTA in previous 6 months
D: Inclusion Criteria:

* Age 40 years and older
* Diabetes mellitus
* Peripheral arterial disease
* Leg symptoms

Exclusion Criteria:

* Myocardial infarction within 3 months of enrollment
* Inability to walk for exercise secondary to chest pain, dyspnea, or poor balance
* Prior major amputation

Answer: C