Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Efficacy of Higher Albendazole and Ivermectin Doses on Wuchereria Bancrofti Microfilarial Clearance in Malawi, Open Label Study
Brief Summary: Albendazole and ivermectin are currently used in combination for annual mass treatment of lymphatic filariasis in Africa. Although the drugs have been donated, the cost of such programmes is very high and has proven to be a major impediment to the success of programmes in many countries with limited financial resources.

Data from albendazole treatment of other filarial infections and one study comparing single to multi-dose Diethycarbamazine/albendazole in lymphatic filariasis suggest that increased dose and/or frequency of albendazole dosing may be more effective in clearing microfilariae. It is essential to determine whether such higher doses are indeed beneficial since this could have far-reaching effects on the conduct and management of the main mass treatment programmes and also in the management of programmes as they near elimination.


Options:
A: Arm Label: DEC + ALB sequential; Type: EXPERIMENTAL; Interventions: Drug: Diethylcarbamazine, Drug: Albendazole | Arm Label: DEC + ALB co-admin; Type: EXPERIMENTAL; Interventions: Drug: Diethylcarbamazine, Drug: Albendazole | Arm Label: DEC + DOXY co-admin; Type: EXPERIMENTAL; Interventions: Drug: Diethylcarbamazine, Drug: Doxycycline | Arm Label: Diethylcarbamazine (DEC); Type: ACTIVE_COMPARATOR; Interventions: Drug: Diethylcarbamazine | Intervention Type: DRUG; Name: Diethylcarbamazine; Assigned to Arm(s): DEC + ALB co-admin, DEC + ALB sequential, DEC + DOXY co-admin, Diethylcarbamazine (DEC) | Intervention Type: DRUG; Name: Albendazole; Assigned to Arm(s): DEC + ALB co-admin, DEC + ALB sequential | Intervention Type: DRUG; Name: Doxycycline; Assigned to Arm(s): DEC + DOXY co-admin
B: Arm Label: standard treatment; Type: ACTIVE_COMPARATOR; Interventions: Drug: Diethylcarbamazine, Drug: Albendazole | Arm Label: DEC 6 mg/kg + Alb 400 mg x 1; Type: EXPERIMENTAL; Interventions: Drug: Diethylcarbamazine, Drug: Albendazole | Arm Label: DEC + ALB + IVM; Type: EXPERIMENTAL; Interventions: Drug: Diethylcarbamazine, Drug: Albendazole, Drug: Ivermectin | Intervention Type: DRUG; Name: Diethylcarbamazine; Assigned to Arm(s): DEC + ALB + IVM, DEC 6 mg/kg + Alb 400 mg x 1, standard treatment | Intervention Type: DRUG; Name: Albendazole; Assigned to Arm(s): DEC + ALB + IVM, DEC 6 mg/kg + Alb 400 mg x 1, standard treatment | Intervention Type: DRUG; Name: Ivermectin; Assigned to Arm(s): DEC + ALB + IVM
C: Arm Label: albendazole 400mg and ivermectin 200mcg/kg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Albendazole 400mg and ivermectin 200mcg/kg | Arm Label: Albendazole 800mg and ivermectin 400mcg/kg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Albendazole and ivermectin | Arm Label: Albendazole 400mg and ivermectin 200mcg/kg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Albendazole 400mg and ivermectin 200mcg/kg | Arm Label: Albendazole 800mg and ivermectin 400mcg /kg bi-annually; Type: ACTIVE_COMPARATOR; Interventions: Drug: albendazole 800mg and ivermectin 400mcg/kg bi-annually | Intervention Type: DRUG; Name: Albendazole 400mg and ivermectin 200mcg/kg; Assigned to Arm(s): Albendazole 400mg and ivermectin 200mcg/kg, albendazole 400mg and ivermectin 200mcg/kg | Intervention Type: DRUG; Name: Albendazole and ivermectin; Assigned to Arm(s): Albendazole 800mg and ivermectin 400mcg/kg | Intervention Type: DRUG; Name: Albendazole 400mg and ivermectin 200mcg/kg; Assigned to Arm(s): Albendazole 400mg and ivermectin 200mcg/kg, albendazole 400mg and ivermectin 200mcg/kg | Intervention Type: DRUG; Name: albendazole 800mg and ivermectin 400mcg/kg bi-annually; Assigned to Arm(s): Albendazole 800mg and ivermectin 400mcg /kg bi-annually
D: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Drug: albendazole + ivermectin + praziquantel | Arm Label: 2; Type: PLACEBO_COMPARATOR; Interventions: Drug: albendazole + ivermectin + (1 week later) praziquantel | Intervention Type: DRUG; Name: albendazole + ivermectin + praziquantel; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: albendazole + ivermectin + (1 week later) praziquantel; Assigned to Arm(s): 2

Answer: C