Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase 3, Randomized, Placebo-Controlled, Blinded, Multicenter Study of the Induction and Maintenance of Clinical Response and Remission by MLN0002 in Patients With Moderate to Severe Ulcerative Colitis
Brief Summary: The primary purpose of this study was to determine the effect of vedolizumab induction treatment on clinical response at 6 weeks and to determine the effect of vedolizumab maintenance treatment on clinical remission at 52 weeks.


Options:
A: Arm Label: 0.03 mg/kg or placebo iv; Type: OTHER; Interventions: Biological: Single dose-group A | Arm Label: 0.1 mg/kg or placebo iv; Type: OTHER; Interventions: Biological: Single dose-group A, Biological: Multiple dose- Group B | Arm Label: 0.3 mg/kg or placebo iv; Type: OTHER; Interventions: Biological: Single dose-group A, Biological: Multiple dose- Group B | Arm Label: 1.0 mg/kg or placebo iv; Type: EXPERIMENTAL; Interventions: Biological: Single dose-group A | Arm Label: 3.0 mg/kg or placebo sc; Type: OTHER; Interventions: Biological: Single dose-group A | Arm Label: 10 mg/kg or placebo iv; Type: OTHER; Interventions: Biological: Single dose-group A | Arm Label: 0.3 mg/kg or placebo sc; Type: OTHER; Interventions: Biological: Single dose-group A, Biological: Multiple dose-Group B | Arm Label: 0.1 mg/kg or placebo iv (multiple dose); Type: OTHER; Interventions: Biological: Multiple dose- Group B | Arm Label: 0.3 mg/kg or placebo iv (multiple dose); Type: OTHER; Interventions: Biological: Multiple dose- Group B | Arm Label: 3.0 mg/kg or placebo iv; Type: OTHER; Interventions: Biological: Multiple dose- Group B | Arm Label: 0.1 mg/kg or placebo sc; Type: OTHER; Interventions: Biological: Multiple dose- Group B | Arm Label: 0.3 mg/kg or placebo sc (multiple dose); Type: OTHER; Interventions: Biological: Multiple dose-Group B | Intervention Type: BIOLOGICAL; Name: Single dose-group A; Assigned to Arm(s): 0.03 mg/kg or placebo iv | Intervention Type: BIOLOGICAL; Name: Single dose-group A; Assigned to Arm(s): 0.1 mg/kg or placebo iv | Intervention Type: BIOLOGICAL; Name: Multiple dose- Group B; Assigned to Arm(s): 0.1 mg/kg or placebo iv (multiple dose) | Intervention Type: BIOLOGICAL; Name: Single dose-group A; Assigned to Arm(s): 0.3 mg/kg or placebo iv | Intervention Type: BIOLOGICAL; Name: Multiple dose- Group B; Assigned to Arm(s): 0.3 mg/kg or placebo iv (multiple dose) | Intervention Type: BIOLOGICAL; Name: Single dose-group A; Assigned to Arm(s): 1.0 mg/kg or placebo iv | Intervention Type: BIOLOGICAL; Name: Single dose-group A; Assigned to Arm(s): 3.0 mg/kg or placebo sc | Intervention Type: BIOLOGICAL; Name: Single dose-group A; Assigned to Arm(s): 10 mg/kg or placebo iv | Intervention Type: BIOLOGICAL; Name: Single dose-group A; Assigned to Arm(s): 0.3 mg/kg or placebo sc | Intervention Type: BIOLOGICAL; Name: Multiple dose-Group B; Assigned to Arm(s): 0.3 mg/kg or placebo sc | Intervention Type: BIOLOGICAL; Name: Multiple dose- Group B; Assigned to Arm(s): 0.1 mg/kg or placebo iv | Intervention Type: BIOLOGICAL; Name: Multiple dose- Group B; Assigned to Arm(s): 0.3 mg/kg or placebo iv | Intervention Type: BIOLOGICAL; Name: Multiple dose- Group B; Assigned to Arm(s): 3.0 mg/kg or placebo iv | Intervention Type: BIOLOGICAL; Name: Multiple dose- Group B; Assigned to Arm(s): 0.1 mg/kg or placebo sc | Intervention Type: BIOLOGICAL; Name: Multiple dose-Group B; Assigned to Arm(s): 0.3 mg/kg or placebo sc (multiple dose)
B: Arm Label: 15 mg BID; Type: EXPERIMENTAL; Interventions: Drug: CP- 690 550 | Arm Label: 10 mg BID; Type: EXPERIMENTAL; Interventions: Drug: CP- 690 550 | Arm Label: 3 mg BID; Type: EXPERIMENTAL; Interventions: Drug: CP- 690 550 | Arm Label: 0.5 mg BID; Type: EXPERIMENTAL; Interventions: Drug: CP- 690 550 | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Intervention Type: DRUG; Name: CP- 690 550; Assigned to Arm(s): 15 mg BID | Intervention Type: DRUG; Name: CP- 690 550; Assigned to Arm(s): 10 mg BID | Intervention Type: DRUG; Name: CP- 690 550; Assigned to Arm(s): 3 mg BID | Intervention Type: DRUG; Name: CP- 690 550; Assigned to Arm(s): 0.5 mg BID | Intervention Type: OTHER; Name: placebo; Assigned to Arm(s): Placebo
C: Arm Label: Vedolizumab; Type: EXPERIMENTAL; Interventions: Drug: vedolizumab | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Intervention Type: DRUG; Name: vedolizumab; Assigned to Arm(s): Vedolizumab | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Placebo
D: Intervention Type: DRUG; Name: SPD476 (mesalazine); Assigned to Arm(s): N/A

Answer: C