Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomized Trial of Antimicrobials Versus Placebo in Addition to Fecal Microbiota Therapy in for the Induction of Remission in Active Ulcerative Colitis
Brief Summary: The investigators will test the hypothesis that giving antibiotics prior to fecal transplant therapy for active UC increases the proportion of patients in remission at the end of treatment. The investigators will randomize patients aged 18 or over with active UC to antibiotics (metronidazole 500mg, doxycycline 100mg, Terbinafine 250 mg, all twice daily for two weeks); or identical placebo. At the end of two weeks the investigators will give all patients fecal transplant therapy twice per week for eight weeks from an anonymous donor stool.). Patients will complete a validated UC questionnaire, have a flexible sigmoidoscopy to assess the degree of inflammation in the colon and complete general and disease specific quality of life questionnaire as well as a questionnaire on anxiety and depression. Patients will complete the same questionnaires again at the end of treatment at week 9 when they will also have a repeat flexible sigmoidoscopy. The main outcome that will be assessed is the proportion of patients in remission from their UC at the end of treatment.


Options:
A: Arm Label: Treatment in part 1; Type: ACTIVE_COMPARATOR; Interventions: Other: Fecal Microbiota Transplantation | Arm Label: Placebo in part 2; Type: PLACEBO_COMPARATOR; Interventions: Other: Normal Saline | Intervention Type: OTHER; Name: Fecal Microbiota Transplantation; Assigned to Arm(s): Treatment in part 1 | Intervention Type: OTHER; Name: Normal Saline; Assigned to Arm(s): Placebo in part 2
B: Arm Label: Metronidazole+doxycylcine+terbinafine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Metronidazole, Drug: Doxycycline, Drug: Terbinafine | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Metronidazole; Assigned to Arm(s): Metronidazole+doxycylcine+terbinafine | Intervention Type: DRUG; Name: Doxycycline; Assigned to Arm(s): Metronidazole+doxycylcine+terbinafine | Intervention Type: DRUG; Name: Terbinafine; Assigned to Arm(s): Metronidazole+doxycylcine+terbinafine | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: Fecal Microbiota Transplantation; Type: ACTIVE_COMPARATOR; Interventions: Biological: Fecal Microbiota Transplantation | Arm Label: Sham Fecal Microbiota Transplantation; Type: SHAM_COMPARATOR; Interventions: Biological: Sham Fecal Microbiota Transplantation | Intervention Type: BIOLOGICAL; Name: Fecal Microbiota Transplantation; Assigned to Arm(s): Fecal Microbiota Transplantation | Intervention Type: BIOLOGICAL; Name: Sham Fecal Microbiota Transplantation; Assigned to Arm(s): Sham Fecal Microbiota Transplantation
D: Arm Label: colonoscope via of FMT; Type: N/A; Interventions: Device: colonoscope | Arm Label: Transendoscopic enteral tubing; Type: N/A; Interventions: Device: transendoscopic enteral tubing | Intervention Type: DEVICE; Name: transendoscopic enteral tubing; Assigned to Arm(s): Transendoscopic enteral tubing | Intervention Type: DEVICE; Name: colonoscope; Assigned to Arm(s): colonoscope via of FMT

Answer: B