Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Protocol for an Randomised Controlled Trial of Smoking Cessation Success Rate With or Without a Genetic Test, "Respiragene", to Assess Lung Cancer Risk - an Exploratory Study
Brief Summary: Professor RP Young (Associate Professor of Medicine and Molecular Medicine, School of Biological Sciences, University of Auckland) and his team have developed a reliable genetic test "Respiragene" based on 20 single nucleotide polymorphisms that can be used (together with details of personal and family history) to calculate a smoker's lifetime risk of developing lung cancer. The expectation is that whatever the score (estimated lifetime risk will vary from 5% to 50%) the result will counter "optimism bias" of the smoker and encourage smoking cessation and this assumption is supported by previous research on similar tests and smoking cessation. The investigators plan to recruit two groups of subjects for smoking cessation but only one group will have the Respiragene test. Eight weekly smoking cessation sessions will be carried out at a Surrey primary care medical centre and will follow the usual format for National Health Service smoking cessation clinics using Champix (varenicline), counselling and the carbon monoxide breath meter but with added: evaluation questionnaires, fagerstrom nicotine addiction score, salivary cotinine (metabolite of nicotine) test. The main outcome measures will be estimation of smoking cessation at 4 weeks and six months after the completion of the seven smoking cessation sessions. Successful smoking cessation has to be confirmed by negative salivary cotinine at 4 weeks and six months and questionnaires will be used to estimate the influence of the Respiragene test compared with standard procedures such as counselling and the carbon monoxide breath readings.


Options:
A: Arm Label: Usual care; Type: PLACEBO_COMPARATOR; Interventions: Behavioral: Usual care | Arm Label: Lung Age; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Lung age | Arm Label: Contingency Management; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Contingency Management | Arm Label: Lung age + Contingency Management; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Lung age + Contingency Management | Intervention Type: BEHAVIORAL; Name: Usual care; Assigned to Arm(s): Usual care | Intervention Type: BEHAVIORAL; Name: Lung age; Assigned to Arm(s): Lung Age | Intervention Type: BEHAVIORAL; Name: Contingency Management; Assigned to Arm(s): Contingency Management | Intervention Type: BEHAVIORAL; Name: Lung age + Contingency Management; Assigned to Arm(s): Lung age + Contingency Management
B: Arm Label: Spirometry and a brief advice to quit smoking; Type: EXPERIMENTAL; Interventions: Behavioral: Spirometry and a brief advice to quit smoking | Arm Label: Brief advice to quit smoking; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Brief advice to quit smoking | Intervention Type: BEHAVIORAL; Name: Spirometry and a brief advice to quit smoking; Assigned to Arm(s): Spirometry and a brief advice to quit smoking | Intervention Type: BEHAVIORAL; Name: Brief advice to quit smoking; Assigned to Arm(s): Brief advice to quit smoking
C: Arm Label: Personalized Risk Information; Type: ACTIVE_COMPARATOR; Interventions: Other: Personalized Heart Attack and Stroke Risk | Arm Label: Standard Education; Type: OTHER; Interventions: Other: Standard Education | Intervention Type: OTHER; Name: Personalized Heart Attack and Stroke Risk; Assigned to Arm(s): Personalized Risk Information | Intervention Type: OTHER; Name: Standard Education; Assigned to Arm(s): Standard Education
D: Arm Label: Control group; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Respiragene test and risk score; Type: EXPERIMENTAL; Interventions: Genetic: Respiragene test and risk score | Intervention Type: GENETIC; Name: Respiragene test and risk score; Assigned to Arm(s): Respiragene test and risk score

Answer: D