Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Randomized Controlled Trial for Investigating a Novel Integrated Care Concept (NICC) for Patients Suffering From Chronic Cardiovascular Disease: CardioCare MV
Brief Summary: Cardiovascular diseases are the number 1 cause of death globally and represent a major economic burden on health care systems. The investigators have developed a novel integrated care concept (NICC) which combines telemedicine with intensive support by a call center, an integrated care network including in- and outpatient care providers and guideline therapy for patients with heart failure (HF), atrial fibrillation (AF) or therapy resistant hypertension (TRH). The aim of the study is to show that NICC is preferable over guideline therapy alone. We aim at including approximately 890 patients. Patients could be enrolled either directly at the Care-Center (location: University Hospital of Rostock) or at one of the advanced treatments rooms of the Care-Center (outpatient cardiological specialist practices).

The ethics commission's statement of the University of Rostock is available for amendment 2 since 20.08.2019 at the number A2017-0117.


Options:
A: Inclusion Criteria:

* Registered at the Primary Healthcare Center as diabetics and/or hypertensive or diagnosed with or suspected to have diabetes and/or hypertension
* Aged 40 years or more
* Lebanese or Palestinian nationality

Exclusion Criteria:

* aged less than 40 years
* Non-Lebanese / Non-Palestinian
* No exclusion based on gender, educational and literacy level, disability, or presence of other medical conditions
B: Inclusion Criteria:

1. age 21 years or older
2. a clinical diagnosis of hypertension with uncontrolled BP in the previous three months, currently taking or about to take anti-hypertensive medications
3. received high school or above level of education
4. active user of smart phone (Android or Apple) and mobile Apps
5. the average of three BP measurements during the screening visit at the CHC is ≥ 140/90 mm Hg, or ≥ 130/80 mm Hg if the patient has diabetes or renal diseases;
6. being able to give informed consent.

Exclusion Criteria:

* acute coronary syndrome
* heart failure
* cardiac arrhythmia
* stroke within the past three months
* renal failure
* cancer
* dementia, severe or acute psychiatric illness, pregnancy or intention to be pregnant in the next 18 months, and hospitalization within 3 months.
* additional exclusion criteria include participation in another clinical trial, arm
* circumference \>32 centimeters that may affect the accuracy of BP measurement due to cuff size limit of the tele-monitor's, and unwillingness to comply with the 12 month intervention duration.
C: Inclusion Criteria:

* Age 18 years or older
* Hypertension
* BP \> 140/90 mmHg or \> 130/80 mmHg if patient has diabetes at the initial screening visit using an approved automated BP monitor.
* If on drug therapy, continuous drug therapy with the same dosing interval for 8 weeks prior to and throughout the screening period. May be drug naive.
* Written informed consent
* Hypertension for at least 12 weeks before screening and throughout the screening period (according to the patient or their medical practitioner)
* Must have a cell phone plan (in Canada) and be willing to maintain the plan during the study. For Tanzania, must have a cell phone under a locally available Tanzanian carrier.
* Must be willing to take occasional local calls from study team members
* One or more of BMI \> 30 kg/m2, diabetes, smoking, over age 40, previous history of CAD including stroke and heart attack
* An identified health care provider in the community (ie. Family Physician/Nurse Practitioner in Canada or Community Nurse/Clinical officer in Tanzania)

Exclusion Criteria:

* Change in antihypertensive medication during the 8 weeks before enrolment
* No cell phone plan compatible with the study.
* Poorly controlled hypertension with BP \> 180/110 mmHg
* No primary health care provider
* Active malignant disease (except non-melanoma skin cancer)
* Unable or unwilling to visit health care provider
* Unable to read the SMS messages (English in Canada and Kiswahili in Tanzania)
* Participation in a clinical trial or receipt of investigational compound or treatment in the 3 months prior to the initial screening visit.
* Planned elective surgery during the study period except for cataract surgery
* \*For BP screening study, must not be on an antihypertensive in the last 6 months.
D: Inclusion Criteria:

1. Heart failure (I50, NYHA II-IV) or atrial fibrillation (I48, EHRA II-IV) or resistant hypertension (I10-15, ≥ 3 antihypertensive medicines from different drug classes, SBP \> 140 /90mmHg or ≥ 4 antihypertensives irrespective of the blood pressure, with at least one drug being a diuretic).
2. Member of health insurance company AOK Nordost or Techniker Krankenkasse (TK).
3. Inscription to integrated care contract with the health insurance company.
4. Residence in Mecklenburg-Vorpommern.
5. Age ≥ 18 years.
6. Written informed consent.

Exclusion Criteria:

1. Pregnancy, suspected pregnancy or breast-feeding period.
2. Participation in another clinical trial up to 30 days before inclusion in this trial.
3. Cognitive deficits: patients need to be able to read and understand German language as presented on a tablet.
4. Chronic kidney disease requiring dialysis or creatinine clearance \< 15 ml/min.

Answer: D