TrialPanorama/Dataset huggingface dataset:
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Bup/Nx - Facilitated Rehab for Opioid Dependent Adolescents
Brief Summary: The purpose of this study is to compare two 3-month treatments for adolescents/young adults who are addicted to heroin: buprenorphine/naloxone combined with psychosocial therapy and treatment as usual, a 7-14 day detoxification with buprenorphine and three weeks of psychosocial therapy.


Options:
A: Inclusion Criteria:

* HIV-infected and receiving continuity care in the Johns Hopkins HIV Clinic
* 18 years of age or older
* Meets DSM-IV criteria for opioid dependence
* Seeks agonist-based treatment for opioid dependence
* Willing and able to provide written informed consent
* Willing to be contacted by mail and telephone for study follow-up visit reminders
* Willing to authorize release of information for substance abuse treatment to the study for a period of 12 months
* If female, negative urine pregnancy test and willingness to practice birth control while on study if sexually active (barrier method or progesterone-containing contraception product)
* Verbal approval from participant's primary HIV clinician

Exclusion Criteria:

* Currently receiving methadone, naloxone, buprenorphine, or levomethadyl acetate (LAAM) as part of a licensed opioid treatment program
* History of allergic reaction to buprenorphine or naloxone
* Active medical need for opioid-based pain control
* Active benzodiazepine abuse or dependence
* Active alcohol dependence
* Alanine aminotransferase level that is more than 5 times the upper limit of normal
* Other condition that, in the opinion of the principal investigator, makes participation in the study unsafe or follow-up highly unlikely
B: Male and non-pregnant female subjects seeking outpatient treatment for opioid dependence with physiological features without serious medical or psychiatric disorders.
C: Inclusion Criteria:

* 18 years old or older
* Physically dependent on opioids
* Meet DSM-IV criteria for opioid dependence

Exclusion Criteria:

* Known allergy or sensitivity to buprenorphine or naloxone
* Unstable psychiatric disorder
* Pregnant or lactating females
* Liver function test results greater than 5 times the upper limit of normal range
D: Inclusion Criteria:

* chronic back pain
* opioid addiction
* not successful with abstinence
* at least 18 years old
* able to understand spoken English
* live in Western New York State (Erie or Niagara county)
* have health insurance or ability to pay for health care
* no methadone or buprenorphine treatment within past year
* not member of a vulnerable population (e.g., pregnancy, prisoner)

Exclusion Criteria:

* homelessness
* unable to give consent (e.g., dementia, psychosis)
* serious heart or lung disease
* taking a medication that could interact with methadone or buprenorphine
* pregnancy

Answer: B
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Bup/Nx - Facilitated Rehab for Opioid Dependent Adolescents
Brief Summary: The purpose of this study is to compare two 3-month treatments for adolescents/young adults who are addicted to heroin: buprenorphine/naloxone combined with psychosocial therapy and treatment as usual, a 7-14 day detoxification with buprenorphine and three weeks of psychosocial therapy.


Options:
A: Inclusion Criteria:

* Females are not pregnant or lactating
* Subjects meet DSM-IV criteria for opiate dependence, are medically and psychiatrically stable, and do not have a current history of benzodiazepine dependence abuse, dependence, or treatment
B: Male and non-pregnant female subjects seeking outpatient treatment for opioid dependence with physiological features without serious medical or psychiatric disorders.
C: Inclusion Criteria:

* Healthy males
* Ages 18-35
* No allergies to morphine or palonosetron
* No history of addiction or substance abuse

Exclusion Criteria:

* Female
* Younger than 18 or older than 35
* History of substance abuse
* Raynaud's disease or coronary artery disease
* Allergies to morphine or palonosetron
D: Inclusion Criteria:

* Current DSM-IV diagnosis of opiate dependence
* Reads and understands English

Exclusion Criteria:

* Serious medical disorders (e.g., uncontrolled hypertension, acute or chronic active hepatitis, kidney failure, uncontrolled diabetes)
* Psychiatric conditions that require intensive services (e.g., depression with suicidal ideation, psychosis)
* Mental retardation or other disorder that might limit ability to give informed consent
* Pregnant

Answer: B
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Bup/Nx - Facilitated Rehab for Opioid Dependent Adolescents
Brief Summary: The purpose of this study is to compare two 3-month treatments for adolescents/young adults who are addicted to heroin: buprenorphine/naloxone combined with psychosocial therapy and treatment as usual, a 7-14 day detoxification with buprenorphine and three weeks of psychosocial therapy.


Options:
A: Male and non-pregnant female subjects seeking outpatient treatment for opioid dependence with physiological features without serious medical or psychiatric disorders.
B: Inclusion Criteria:

* current opiate or cocaine use
* HCV seronegative
* able to complete the study procedures in English

Exclusion Criteria:

* current enrollment in a formal substance abuse treatment program
C: Inclusion Criteria:

* age 15-30 years old
* self-reported illicit drug injection within the past 6 months
* live in the geographic region under study and plan to stay for \>12 months
* willing to provide a blood sample for serologic testing
* willing to provide basic contact information for follow-up
* able to communicate in English
* had not participated in the pilot study or previously enrolled in the trial
* not concurrently participating in other HIV or HCV intervention trials
* tested HIV and HCV seronegative at baseline

Exclusion Criteria:

-
D: Inclusion Criteria:

* 18 to 70 years patients needing methadone for their opioid dependence who are either naives of methadone treatment (prescribed) since at least 1 month
* need to switch from buprenorphine to methadone treatment
* negative test for pregnancy

Exclusion Criteria:

* co-dependent on alcohol and benzodiazepines,
* inmates,
* pregnant women,
* individual in irregular situation or who cannot be joined by phone.

Answer: A
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Motivational Enhancement Therapy (MET) to Improve Treatment Utilization in Pregnant Substance Users
Brief Summary: The purpose of this study is to compare Motivational Enhancement Therapy (MET) with standard drug abuse treatment among pregnant women.


Options:
A: Inclusion Criteria:

* Pregnancy \<30 weeks
* Have not attended drug treatment in past 28 days
* Not needing residential treatment (except detox)
* Not at risk for suicide/homicide
* Have no pending legal charges (except drug treatment)
B: Inclusion Criteria: 1

* 12-18
* speak English

Exclusion Criteria:

* cognitive impairment
C: Inclusion Criteria:

* Male or Female age 18 or older
* Serum antibody and polymerase chain reaction positive for hepatitis C
* Drinking greater than 7 drinks for each of the proceeding 2 weeks or one day heavy drinking day per week for 2 week (heavy drinking day:\>4 drinks in one day)
* Diagnosed with alcohol abuse or dependence

Exclusion Criteria:

* Diagnosis of cocaine, methamphetamine or opioid dependence within the past 6 months
* Unable to attend clinic appointments
* Any known pre-existing medical conditions that could interfere with participation in the protocol, such as: CNS trauma, known cognitive impairment, dementia, encephalopathy from liver disease, acute psychiatric instability, such as significant psychosis, mania, or elevated risk for suicide
D: Inclusion Criteria:

* Self-report of illicit and/or prescription drug misuse in the past three-months. Presenting at the emergency department for medical care.

Exclusion Criteria:

Not age appropriate, in custody, medically unstable, actively psychotic, suicidal

-

Answer: A
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Women's Treatment for Trauma and Substance Use Disorders
Brief Summary: The purpose of this study is to compare the effectiveness of adding Seeking Safety to standard substance abuse treatment to adding a control condition: Women's Health Education to standard substance abuse treatment.


Options:
A: Inclusion Criteria:

* Male and female inpatients 18 years of age or older.
* Participants will have a current DSM-IV diagnosis of alcohol abuse or dependence.
* Able to understand/speak English
* Participants will have signed a witnessed informed consent.

Exclusion Criteria:

* Cognitive impairment (e.g., mental retardation)
* Participants who meet current DSM-IV criteria for bipolar disorder, schizophrenia, or dementia
* Participants who are homeless, without contact person
* Participants enrolled in a methadone maintenance treatment program.
B: Inclusion Criteria:

* 18 yo
* meets Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for alcohol dependence

Exclusion Criteria:

* acute medical or psychiatric problems that require inpatient treatment (e.g., acute psychosis, or suicide/homicide risk)
* reading ability below the fifth grade level
* lack of reliable transportation to the treatment site, or excessive commuting distance
* inability to understand English
C: Inclusion Criteria - Women with a diagnosis of substance abuse or dependence who also have either full or sub-threshold DSM-IV PTSD.

Exclusion Criteria:

- Women will be excluded from the study who have current psychotic disorders, or a history of active psychosis (past two months); women with a diagnosis of substance abuse or dependence who also have either full or sub-threshold DSM-IV PTSD; and women who have current psychotic disorders, or a history of active psychosis (past two months).
D: Inclusion Criteria:

To be eligible for the study participants must:

1. Be 18 years or older
2. Live in RI or MA within 20 miles of Providence and plan to remain in the area for the next 6 months
3. Meet DSM-IV criteria for alcohol abuse or dependence in the last six months
4. Do not expect to attend residential alcohol or drug treatment upon release
5. Report STI/HIV sexual risk defined as unprotected heterosexual sex at least three times in the three months prior to incarceration
6. Speak English.
7. Be currently held at the Rhode Island Adult Correctional Institutions Jail facility

Women will be excluded from participation if they:

1. Cannot provide the name of at least two locator persons who will know where they can be found.

Answer: C
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Women's Treatment for Trauma and Substance Use Disorders
Brief Summary: The purpose of this study is to compare the effectiveness of adding Seeking Safety to standard substance abuse treatment to adding a control condition: Women's Health Education to standard substance abuse treatment.


Options:
A: Inclusion Criteria:

* Exposed to a traumatic event at an adult age
* Primary PTSD diagnosis according to the DSM-5 criteria
* At least one PTSD related problem (depressive, anxiety or sleep disorders, pain, psychosocial stressors, inadequate social support, substance use disorder)
* Being fluent in French.

Exclusion Criteria:

* Schizophrenia diagnostic, current or past psychotic episodes, bipolar disorder, organic cerebral disorder or intellectual deficiency
* Presence of a trouble linked to a substance developed prior to the traumatic event
* Physical condition preventing participation in the study (e.g. cerebral trauma)
* Presence of active suicide ideas.
B: Inclusion Criteria:

* 18 years of age or older,
* willing to undertake the qigong intervention program,
* available for all testing points,
* receptive to random allocation, and
* assessed to be abused by an intimate partner in the preceding year or longer, based on the Chinese Abuse Assessment Screen.

Exclusion Criteria:

* had participated in qigong training or other mind body intervention within the previous 6 months, or
* have serious medical conditions that might limit their participation in qigong exercise (based on our previous experience, such conditions include cancer, severe obesity, narcolepsy, major depressive disorder, schizophrenia), or
* have psychiatric disorders, or
* use medication or other psychological intervention for stress, or
* are abused by someone who is not their intimate partner.
C: Inclusion Criteria:

* Pregnant or postpartum women (up to 6 months after delivery)
* Age 18 or older
* Seeking mental health treatment at The Center for Women's Behavioral Health (WBH) at Women and Infants Hospital (WIH)
* Endorsed any IPV during the past 12 months as measured by the Woman Abuse Screening Tool (WAST)

Exclusion Criteria:

* Inability to provide informed consent (e.g., due to psychosis, intoxication, or other clear cognitive impairment)
* Inability to understand English (understand the consent form when read aloud and assessments that are narrated by computer)
D: Inclusion Criteria - Women with a diagnosis of substance abuse or dependence who also have either full or sub-threshold DSM-IV PTSD.

Exclusion Criteria:

- Women will be excluded from the study who have current psychotic disorders, or a history of active psychosis (past two months); women with a diagnosis of substance abuse or dependence who also have either full or sub-threshold DSM-IV PTSD; and women who have current psychotic disorders, or a history of active psychosis (past two months).

Answer: D
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Benefits & Risks of Popular Weight Loss Diets
Brief Summary: This study will compare the safety and effectiveness of three popular weight loss plans. These plans will be compared with the USDA Dietary Guidelines.


Options:
A: Inclusion Criteria:

* healthy, slightly overweight (body mass index, BMI = 25-30 kg/m2) women, premenopausal, non-alcoholic (\< 14 units alcohol/w)

Exclusion Criteria:

* smoking, elite athletes, food allergies, pregnant, lactating, on medication, blood donation 3 months before, during and 3 months after the completion of the study
B: Inclusion Criteria

* Body mass index (BMI) between 27 and 40 kg/m2
* Weight stable for last 2 months
* Not actively on a weight loss plan
* No plans to move from the area over the next 2 years
* Willing to accept random assignment

Exclusion Criteria

* Pregnant or breastfeeding
* Within 6 months of giving birth or planning to become pregnant in the next 2 years
* Diabetes (type 1 or 2) or history of gestational diabetes
* Renal or liver disease, active neoplasms, or recent myocardial infarction
* Hyper- or hypothyroidism
* Lipid lowering medications or medications known to affect weight/energy expenditure
* Excessive alcohol intake (self-reported, \> 3 drinks/day)
* Postmenopausal, including surgical menopause
* Currently under psychiatric care or severely clinically depressed (\> 17 on Beck Inventory)
C: Inclusion Criteria:

* abdominal obesity

Exclusion Criteria:

* BMI \> 45, previous weight change
D: Inclusion criteria

1. Males age 18 to 35 years
2. BMI less than or equal to 25 for age and gender

Exclusion criteria

1. weight \> 300 lbs
2. largest body circumference \> 144cm
3. body shape incompatible with MRI scanner or equipment
4. MRI exclusion criteria
5. large fluctuations in body weight (5% over preceding 6 months, 2.5% during the study)
6. known medical problems that may affect metabolism or hormones
7. diabetes mellitus (fasting plasma glucose ≥126 mg/dL)
8. other abnormal laboratory screening tests
9. taking any medications or dietary supplements that might affect body weight, appetite, or energy expenditure
10. smoking or illicit substance abuse
11. high levels of physical activity (\>30 minutes per day, \> 4days per week)
12. currently following a weight loss diet
13. allergies or intolerance to eggs, vanilla extract, equal, canola oil, milk, cornstarch, corn syrup

Answer: B
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Benefits & Risks of Popular Weight Loss Diets
Brief Summary: This study will compare the safety and effectiveness of three popular weight loss plans. These plans will be compared with the USDA Dietary Guidelines.


Options:
A: Inclusion Criteria:

* Self-identify as African American
* Be between the ages of 18-65 years
* Body Mass Index between 25- 49.9 kg/m2
* Live in the Columbia, SC/Midlands area
* Be able to attend all monitoring and weekly class visits
* Be willing to be randomized to either diet

Exclusion Criteria:

* Currently following a vegan diet
* Diagnosed with diabetes that is controlled by medication
* Currently pregnant or breastfeeding (or plan to become pregnant in the next 24 months)
* Under the age of 18 years old
* Over the age of 65 years old
* Currently participating in a weight loss program
* Has lost more than 10 pounds in the past 6 months
* Diagnosed with stroke or heart attack
B: Postmenopausal women ages 50 to 79.
C: Inclusion Criteria:

* Male or female subjects \> 18 years of age
* Clinical diagnosis of type 2 diabetes mellitus or on insulin or oral hypoglycemic agents
* Body mass index of \> 30 kg/m2
* The subject must we willing and able to monitor their blood glucose with a glucometer at least 2 times per week.
D: Inclusion Criteria

* Body mass index (BMI) between 27 and 40 kg/m2
* Weight stable for last 2 months
* Not actively on a weight loss plan
* No plans to move from the area over the next 2 years
* Willing to accept random assignment

Exclusion Criteria

* Pregnant or breastfeeding
* Within 6 months of giving birth or planning to become pregnant in the next 2 years
* Diabetes (type 1 or 2) or history of gestational diabetes
* Renal or liver disease, active neoplasms, or recent myocardial infarction
* Hyper- or hypothyroidism
* Lipid lowering medications or medications known to affect weight/energy expenditure
* Excessive alcohol intake (self-reported, \> 3 drinks/day)
* Postmenopausal, including surgical menopause
* Currently under psychiatric care or severely clinically depressed (\> 17 on Beck Inventory)

Answer: D
Please select the eligibility criteria that correspond to the clinical trial below.
Title: N/A
Brief Summary: The purpose of this study is to compare the effects of three types of treatments for depressed teenagers who have attempted suicide.


Options:
A: Inclusion Criteria:

* Hospitalization in a participating psychiatric facility
* Suicidal ideation, intent, or attempt

Exclusion Criteria:

* Severe physical or cognitive impairment that makes informed consent, nominations, or participation in assessments impossible
B: Inclusion Criteria:

* At least one suicide attempt or interrupted attempt within the past 45 days
* Continuously reside with a primary caretaker (parent, legal guardian, foster parent) for at least 6 months that can provide legal consent
C: Inclusion Criteria:

* Child and adolescent patients with bipolar I disorder, manic or mixed episode with or without psychotic features

Exclusion Criteria:

* Patients with certain other psychological disorders
* Patients with a co-morbid serious, uncontrolled systemic illness
* Patients with significant risk of committing suicide
D: Inclusion Criteria:

* Suicidal ideation (SIQ-JR \> 30)
* Moderate depressed mood (BDI-II \> 19)
* At least one parent/caregiver willing to participate

Exclusion Criteria:

* Psychosis
* Mental retardation or other significant cognitive impairment

Answer: B
Please select the eligibility criteria that correspond to the clinical trial below.
Title: N/A
Brief Summary: The purpose of this study is to compare the effects of three types of treatments for depressed teenagers who have attempted suicide.


Options:
A: Inclusion Criteria:

* Meets criteria for alcohol use disorder and major depressive disorder.

Exclusion Criteria:

* Meets criteria for bipolar disorder, schizoaffective disorder, or schizophrenia.
* Hyper- or hypothyroidism, significant cardiac, neurologic, or renal impairment, and those with significant liver disease.
* Receiving antipsychotic or antidepressant medication in the month prior to entering the study.
* Use of any illicit substance abuse or dependence other than cannabis abuse (and alcohol abuse).
* History of intravenous drug use.
* Pregnancy, inability or unwillingness to use contraceptive methods.
* Inability to read or understand study forms
* Less than 15 years of age or over 18 years of age will be excluded.
B: Inclusion Criteria:

* Age 13-19
* Diagnosis of Major Depression

Exclusion Criteria:

* History of mania/hypomania
* Current psychotic symptoms
* Substance dependence
* Medical conditions (contraindication for sertraline)
* Pregnancy
* Past treatment with sertraline
C: Inclusion criteria:

* Major depressive disorder, dysthymic disorder, or bipolar disorder (Type I or II)
* IQ greater than 70
* At least one parent/caregiver willing to participate in the study
* Able to attend six or more of the eight treatment sessions with at least 1 parent
D: Inclusion Criteria:

* At least one suicide attempt or interrupted attempt within the past 45 days
* Continuously reside with a primary caretaker (parent, legal guardian, foster parent) for at least 6 months that can provide legal consent

Answer: D
Please select the eligibility criteria that correspond to the clinical trial below.
Title: Community-Based Cognitive Therapy for Suicide Attempters
Brief Summary: This study will determine the effectiveness of cognitive behavioral therapy (CBT) in preventing future suicide attempts in repeat suicide attempters.


Options:
A: Inclusion Criteria:

* Age 18 to 27
* Currently enrolled in college
* Meet at least 4 of 9 Criteria of BPD (DSM-V) with one criterion being self-harm (e.g. cut, burn, or hit self)

Exclusion Criteria:

* have a current major psychiatric disorder diagnosis, or other gross cognitive impairment (as identified in the phone screen or the SCID I measure) or
* have undergone DBT or
* are suicidal and require full DBT and/or hospitalization or
* are currently in any other individual or group therapy
* unable to attend weekly visits over 8 weeks, starting March 24, 2014
B: Inclusion Criteria:

* Current diagnosis of Axis I anxiety disorder (based on M.I.N.I.)
* Diagnosis of comorbid personality disorder (based on SCID II) or depressive disorder (based on M.I.N.I.)
* Age: 18 to 65 years
* Sufficient knowledge of the Polish language
* Written informed consent of the patient

Exclusion Criteria:

* Organic disorder
* Acute substance related disorders
* Schizophrenia, bipolar affective disorder
* Severe depression \[over 26 points in Beck Questionnaire\] or bipolar disorder.
* Dissocial personality disorder, schizotypal personality disorder
* Current suicidal ideation with a high risk of suicide
* Restriction of intellectual capacity
* Serious unstable medical problems/complications
* Concurrent psychotherapeutic treatment
* Failed treatment of CBT or psychodynamic psychotherapy for anxiety
C: Inclusion Criteria:

* Suicide attempt within 48 hours prior to being evaluated at the hospital
* English speaking
* Able to provide 2 verifiable contacts

Exclusion Criteria:

* Acute, unstable, or severe Axis III disorder or a severe Axis I disorder that may prevent safe participation in outpatient psychotherapy
D: Inclusion Criteria:

We propose to include all patients at the participating sites who:

* Complete PHQ questionnaire and respond to item 9 (regarding thoughts of death or self-harm) "more than half the days" or "nearly every day"
* Are currently enrolled in one of the four participating health systems
* Are age 18 or older
* Recent use of Epic Secure Messaging

Exclusion Criteria:

* Recorded diagnosis of dementia or developmental delay
* Previously invited to participate in the UH2 pilot trial
* Non-English speaker

Answer: C