Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Efficacy and Safety of Targeting Lower Arterial Oxygen Saturations to Reduce Oxygen Toxicity and Oxidative Stress in Very Preterm Infants: The Canadian Oxygen Trial (COT)
Brief Summary: Study Question: In infants who are born at gestational ages of 23 0/7 to 27 6/7 weeks, does lowering the concentration of supplemental oxygen to target an arterial oxygen saturation by pulse oximetry (SpO2)of 85-89% compared with 91-95%, from the day of birth until the baby's first discharge home, increase the probability of survival without severe neurosensory disability to a corrected age of 18 months?


Options:
A: Arm Label: High Oxygen saturation; Type: EXPERIMENTAL; Interventions: Procedure: Higher oxygen saturation target range (91%-95%) | Arm Label: Lower oxygen saturation; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Lower oxygen saturation (85%-89%) | Intervention Type: PROCEDURE; Name: Higher oxygen saturation target range (91%-95%); Assigned to Arm(s): High Oxygen saturation | Intervention Type: PROCEDURE; Name: Lower oxygen saturation (85%-89%); Assigned to Arm(s): Lower oxygen saturation
B: Arm Label: Surfactant and Low Oxygen; Type: EXPERIMENTAL; Interventions: Drug: Surfactant, Drug: Supplemental oxygen with target saturation of 85 to 89% | Arm Label: Surfactant and High Oxygen; Type: EXPERIMENTAL; Interventions: Drug: Surfactant, Drug: Supplemental oxygen with target saturation of 91 to 95% | Arm Label: CPAP and Low Oxygen; Type: EXPERIMENTAL; Interventions: Device: Continuous Positive Airway Pressure (CPAP), Drug: Supplemental oxygen with target saturation of 85 to 89% | Arm Label: CPAP and High Oxygen; Type: EXPERIMENTAL; Interventions: Device: Continuous Positive Airway Pressure (CPAP), Drug: Supplemental oxygen with target saturation of 91 to 95% | Intervention Type: DRUG; Name: Surfactant; Assigned to Arm(s): Surfactant and High Oxygen, Surfactant and Low Oxygen | Intervention Type: DEVICE; Name: Continuous Positive Airway Pressure (CPAP); Assigned to Arm(s): CPAP and High Oxygen, CPAP and Low Oxygen | Intervention Type: DRUG; Name: Supplemental oxygen with target saturation of 85 to 89%; Assigned to Arm(s): CPAP and Low Oxygen, Surfactant and Low Oxygen | Intervention Type: DRUG; Name: Supplemental oxygen with target saturation of 91 to 95%; Assigned to Arm(s): CPAP and High Oxygen, Surfactant and High Oxygen
C: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Other: Titration of oxygen therapy | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Other: Titration of oxygen therapy | Intervention Type: OTHER; Name: Titration of oxygen therapy; Assigned to Arm(s): 1, 2
D: Arm Label: Low Oxygen Strategy; Type: EXPERIMENTAL; Interventions: Procedure: Titration of oxygen during newborn resuscitation in delivery room | Arm Label: Traditional Oxygen strategy ( TOX); Type: ACTIVE_COMPARATOR; Interventions: Procedure: Titration of oxygen during newborn resuscitation in delivery room | Intervention Type: PROCEDURE; Name: Titration of oxygen during newborn resuscitation in delivery room; Assigned to Arm(s): Low Oxygen Strategy, Traditional Oxygen strategy ( TOX)

Answer: C