Please select the eligibility criteria that correspond to the clinical trial below.
Title: Improving the Delivery of Intensive Gait Training in the Clinical Setting to Augment Community Ambulation
Brief Summary: The purpose of this study is to demonstrate the efficacy of intensive locomotor interventions early post stroke. An intensive locomotor training (LT) program will be compared to an active control, conventional physical therapy. It is proposed that an early and intensive stepping paradigm that is not typically employed early in physical therapy will lead to superior outcomes and improved community mobility. A randomized, blinded, controlled trial will test subjects with moderate to severe locomotor dysfunction in individuals post-stroke to compare walking-related outcomes after intensive gait training (including treadmill, overground, stair training, and skilled walking training) to outcomes after conventional physical therapy.


Options:
A: Inclusion Criteria:

* Informed consent
* Clinical diagnosis of first or recurrent stroke, hemorrhage or infarct.
* Recruited within 24 hours of onset of stroke symptoms
* Admission in a stroke care unit
* Consciousness: At a minimum patient must at least react to verbal commands.

Exclusion Criteria:

* pre stroke mRS of 3,4 or 5
* Deterioration in patients condition resulting in direct admission to ICU, decision to palliate or surgery.
* Concurrent diagnosis of rapidly deteriorating disease
* Unstable coronary or other medical condition that is judged by the investigator to impose a hazard to the patient by involvement
* Patients unable to be mobilized within 24 hours of onset. (eg bed rest policy post tPA, lower limb fracture)
* Other interventional trials
* Systolic BP less than 110 or greater than 220mmHg
* Oxygen saturation of less than 92 % with supplementation
* Resting heart rate of less than 40 or greater than 110 beats per minute
* Temperature of greater than 38.5 degrees C
B: Inclusion Criteria:

* subacute (\<6 months) stroke
* 18-75 years old
* history of history of unilateral, supratentorial, ischemic or hemorrhage stroke
* able to walk 10m without physical assistance
* gait speed less than or equal to .8m/s
* medical clearance

Exclusion Criteria:

* significant cardiorespiratory or metabolic disease that may limit exercise participation
* weight limit \> 250 lbs (limit of most counter-weight safety systems)
* history of previous orthopedic or neurological conditions which may impair walking.
* women of childbearing potential will not be excluded, although women who are pregnant will be excluded due to potential forces at trunk from the harness applied at the waist.
* subjects with scores \< 23 on the Mini Mental Status Exam

  * Exclusion for transcranial magnetic stimulation (TMS):
* pacemaker
* metal implants in the head region
* history of epilepsy or seizures
* skull fractures or skull deficits
* concussion within the last 6 months
* unexplained recurring headaches
* medications that lower seizure threshold
* pregnancy

  * Exclusion for the MRI:
* aneurysm clip or coil
* metal or wire implants
* heart valve prosthesis
C: Inclusion Criteria:

* Mild-moderate hemiparetic gait
* \> 6 months post-stroke
* Able to perform flywheel leg-press exercise

Exclusion Criteria:

* Unstable angina
* Congestive heart failure
* Severe arterial disease
* Major depression
* Dementia
* Chronic pain
* Psychotic alterations
D: Inclusion Criteria:

* diagnosed with stroke
* 18 years of age or older
* community dwelling
* able to walk 10m independently, with or without an assistive device
* medically approved by a physician to participate
* able to tolerate 60 minutes of activity with rest intervals
* able to independently follow instructions

Exclusion Criteria:

* involved in an active rehabilitation program

Answer: B