Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Lactobacillus Reuteri in Treatment of Functional Abdominal Pain and Chronic Constipation in Children - Randomized, Double Blind, Placebo Controlled Study
Brief Summary: Beneficial therapeutic effect of probiotics has been reported in children with irritable bowel syndrome, but not consistently in other functional gastrointestinal disorders. Although there is evidence that probiotics increase stool frequency and decrease stool consistency in healthy individuals the evidence for efficacy in constipation is limited.

Children with functional abdominal pain (FAP) and constipation will be included in the study. Children with FAP will be randomized in one of two groups and will receive either L. reuteri in a daily dose of 108 CFU, or placebo during three months. Children with chronic constipation will receive either L. reuteri in a daily dose of 108 CFU and lactulose, or placebo and lactulose. Frequency and intensity of episodes of abdominal pain during and after intervention will be recorded in children with FAP. Frequency of defecation, stool consistency and need for lactulose will be recorded in children with chronic constipation.


Options:
A: Arm Label: Probiotics supplementation; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Probiotics | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: Probiotics; Assigned to Arm(s): Probiotics supplementation | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo; Assigned to Arm(s): Placebo
B: Arm Label: Probiotic/abdominal pain; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Administration of L.reuteri in children with abdominal pain | Arm Label: Placebo/abdominal pain; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Administration of placebo in children with abdominal pain | Arm Label: Probiotic/constipation; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Administration of L.reuteri in children with constipation | Arm Label: Placebo/chronic constipation; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Administration of placebo in children with constipation | Intervention Type: DIETARY_SUPPLEMENT; Name: Administration of L.reuteri in children with abdominal pain; Assigned to Arm(s): Probiotic/abdominal pain | Intervention Type: DIETARY_SUPPLEMENT; Name: Administration of placebo in children with abdominal pain; Assigned to Arm(s): Placebo/abdominal pain | Intervention Type: DIETARY_SUPPLEMENT; Name: Administration of L.reuteri in children with constipation; Assigned to Arm(s): Probiotic/constipation | Intervention Type: DIETARY_SUPPLEMENT; Name: Administration of placebo in children with constipation; Assigned to Arm(s): Placebo/chronic constipation
C: Arm Label: Mixture of three Bifidobacteria; Type: ACTIVE_COMPARATOR; Interventions: Drug: Mixture of three Bifidobacteria | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Mixture of three Bifidobacteria | Intervention Type: DRUG; Name: Mixture of three Bifidobacteria; Assigned to Arm(s): Mixture of three Bifidobacteria, Placebo
D: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo | Arm Label: Saccharomyces cerevisiae CNCM I-3856; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Saccharomyces cerevisiae CNCM I-3856 | Intervention Type: DIETARY_SUPPLEMENT; Name: Saccharomyces cerevisiae CNCM I-3856; Assigned to Arm(s): Saccharomyces cerevisiae CNCM I-3856 | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo; Assigned to Arm(s): Placebo

Answer: B