Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Urgent vs. Early Endoscopy in High Risk Patients With UGIB
Brief Summary: Acute upper gastrointestinal bleeding (UGIB) is one of the commonest medical emergencies. The condition accounts for 150 per 100,000 populations. A National United Kingdom reported a crude overall mortality rate of 10%. While bleeding stops spontaneously in majority of patients at their presentation, there remains a subgroup of patients who continue to bleed or develop recurrent bleeding. In these patients, the mortality increases manifolds. If these high-risk patients can be identified, early interventions may improve their outcomes.

Several prognostic indices are in use for the purpose of patient stratification. They include the Rockall, Glasgow-Blatchford (GBS) and the Baylor scores. The Rockall score is a composite score which incorporates clinical parameters as well as findings during endoscopy which was derived to predict mortality. The GBS is a pre-endoscopy or a clinical score for the prediction for the need of further intervention loosely defined as the need for transfusion, endoscopy or surgery. It has been shown to be accurate in identifying low risk patients for early discharge.


Options:
A: Arm Label: Over-the-scope Clips; Type: EXPERIMENTAL; Interventions: Device: Over-the-scope Clips | Arm Label: standard treatment; Type: ACTIVE_COMPARATOR; Interventions: Device: Hemo-clipping, Device: thermo-coagulation, Drug: Epinephrine | Intervention Type: DEVICE; Name: Over-the-scope Clips; Assigned to Arm(s): Over-the-scope Clips | Intervention Type: DEVICE; Name: Hemo-clipping; Assigned to Arm(s): standard treatment | Intervention Type: DEVICE; Name: thermo-coagulation; Assigned to Arm(s): standard treatment | Intervention Type: DRUG; Name: Epinephrine; Assigned to Arm(s): standard treatment
B: Arm Label: Urgent endoscopy; Type: ACTIVE_COMPARATOR; Interventions: Other: Urgent endoscopy | Arm Label: Early endoscopy; Type: PLACEBO_COMPARATOR; Interventions: Other: Early endoscopy | Intervention Type: OTHER; Name: Urgent endoscopy; Assigned to Arm(s): Urgent endoscopy | Intervention Type: OTHER; Name: Early endoscopy; Assigned to Arm(s): Early endoscopy
C: Arm Label: TC-325; Type: EXPERIMENTAL; Interventions: Device: Endoscopic Application of a Hemostatic Powder TC-325 | Arm Label: standard treatment; Type: ACTIVE_COMPARATOR; Interventions: Device: Hemo-clipping, Drug: Epinephrine, Device: thermo-coagulation | Intervention Type: DEVICE; Name: Endoscopic Application of a Hemostatic Powder TC-325; Assigned to Arm(s): TC-325 | Intervention Type: DEVICE; Name: Hemo-clipping; Assigned to Arm(s): standard treatment | Intervention Type: DRUG; Name: Epinephrine; Assigned to Arm(s): standard treatment | Intervention Type: DEVICE; Name: thermo-coagulation; Assigned to Arm(s): standard treatment
D: Arm Label: Erythromycin; Type: ACTIVE_COMPARATOR; Interventions: Drug: Erythromycin | Arm Label: Placebo Group endoscopic therapy; Type: NO_INTERVENTION; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Erythromycin; Assigned to Arm(s): Erythromycin | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo Group endoscopic therapy

Answer: B