Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Safety and Efficacy of Four Intramuscular Interventions for the Management of Acute Psychomotor Agitation
Brief Summary: This study aims to evaluate the efficacy and safety of four options of medications in the management of acute psychomotor agitation,or violence and aggression situations in health services. All of the treatment options are already approved and currently used for this purpose. The options are: haloperidol plus midazolam, haloperidol plus promethazine, olanzapine and ziprasidone. The investigators hypothesized that all treatment options are effective in the treatment of acute agitation, but the combination haloperidol plus promethazine could elicit more adverse affects than the others.


Options:
A: Arm Label: Aripiprazole depot 300 or 400 mg; Type: EXPERIMENTAL; Interventions: Drug: Aripiprazole depot 300 or 400 mg, Drug: Placebo tablets | Arm Label: Aripiprazole 10-30 mg orally; Type: ACTIVE_COMPARATOR; Interventions: Drug: Aripiprazole 10-30 mg orally, Drug: Placebo depot | Arm Label: Aripiprazole depot 25 or 50 mg; Type: EXPERIMENTAL; Interventions: Drug: Aripiprazole depot 25 or 50 mg, Drug: Placebo tablets | Intervention Type: DRUG; Name: Aripiprazole depot 300 or 400 mg; Assigned to Arm(s): Aripiprazole depot 300 or 400 mg | Intervention Type: DRUG; Name: Aripiprazole 10-30 mg orally; Assigned to Arm(s): Aripiprazole 10-30 mg orally | Intervention Type: DRUG; Name: Aripiprazole depot 25 or 50 mg; Assigned to Arm(s): Aripiprazole depot 25 or 50 mg | Intervention Type: DRUG; Name: Placebo depot; Assigned to Arm(s): Aripiprazole 10-30 mg orally | Intervention Type: DRUG; Name: Placebo tablets; Assigned to Arm(s): Aripiprazole depot 25 or 50 mg, Aripiprazole depot 300 or 400 mg
B: Arm Label: Cariprazine 3mg; Type: EXPERIMENTAL; Interventions: Drug: Cariprazine | Arm Label: Cariprazine 6mg; Type: EXPERIMENTAL; Interventions: Drug: Cariprazine | Arm Label: Aripiprazole 10mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Aripiprazole | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Cariprazine; Assigned to Arm(s): Cariprazine 3mg, Cariprazine 6mg | Intervention Type: DRUG; Name: Aripiprazole; Assigned to Arm(s): Aripiprazole 10mg | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: ziprasidone injection; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ziprasidone | Arm Label: haloperidol + midazolam, injection; Type: ACTIVE_COMPARATOR; Interventions: Drug: haloperidol + midazolam | Arm Label: haloperidol + promethazine, injection; Type: ACTIVE_COMPARATOR; Interventions: Drug: haloperidol+promethazine | Arm Label: olanzapine, injection; Type: ACTIVE_COMPARATOR; Interventions: Drug: olanzapine | Intervention Type: DRUG; Name: haloperidol+promethazine; Assigned to Arm(s): haloperidol + promethazine, injection | Intervention Type: DRUG; Name: haloperidol + midazolam; Assigned to Arm(s): haloperidol + midazolam, injection | Intervention Type: DRUG; Name: olanzapine; Assigned to Arm(s): olanzapine, injection | Intervention Type: DRUG; Name: Ziprasidone; Assigned to Arm(s): ziprasidone injection
D: Intervention Type: DRUG; Name: Paliperidone ER; Assigned to Arm(s): N/A

Answer: C