Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: pRotective vEntilation With Veno-venouS Lung assisT in Respiratory Failure
Brief Summary: This is a trial of a new way of treating patients with respiratory failure. The investigators propose to deliver a multi-centre clinical trial to determine whether veno-venous extracorporeal carbon dioxide removal (VV-ECCO2R) and lower tidal volume mechanical ventilation improves outcomes and is cost-effective, in comparison with standard care in patients who are mechanically ventilated for acute hypoxaemic respiratory failure


Options:
A: Arm Label: ECMO arm; Type: EXPERIMENTAL; Interventions: Device: ECMO (Quadrox®, Jostra®, Maquet®) | Arm Label: conventional arm; Type: ACTIVE_COMPARATOR; Interventions: Other: conventional care | Intervention Type: DEVICE; Name: ECMO (Quadrox®, Jostra®, Maquet®); Assigned to Arm(s): ECMO arm | Intervention Type: OTHER; Name: conventional care; Assigned to Arm(s): conventional arm
B: Arm Label: One single arm; Type: EXPERIMENTAL; Interventions: Device: ECCO2R will be initiated during the 2-hour run-in time, Other: Neuromuscular blocking agents (NMBA), Device: Ventilation, Other: Level of carbon dioxide released at the end of expiration, Other: Respiratory Rate, Other: Sweep gas flow, Other: Ventilation will be adapted, Other: Respiratory rate will be adapted | Intervention Type: DEVICE; Name: ECCO2R will be initiated during the 2-hour run-in time; Assigned to Arm(s): One single arm | Intervention Type: OTHER; Name: Neuromuscular blocking agents (NMBA); Assigned to Arm(s): One single arm | Intervention Type: DEVICE; Name: Ventilation; Assigned to Arm(s): One single arm | Intervention Type: OTHER; Name: Level of carbon dioxide released at the end of expiration; Assigned to Arm(s): One single arm | Intervention Type: OTHER; Name: Respiratory Rate; Assigned to Arm(s): One single arm | Intervention Type: OTHER; Name: Sweep gas flow; Assigned to Arm(s): One single arm | Intervention Type: OTHER; Name: Ventilation will be adapted; Assigned to Arm(s): One single arm | Intervention Type: OTHER; Name: Respiratory rate will be adapted; Assigned to Arm(s): One single arm
C: Arm Label: Standard Care; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: ECCO2R to enable lower tidal volume mechanical ventilation; Type: EXPERIMENTAL; Interventions: Device: VV-ECCO2R to enable lower tidal volume mechanical ventilation | Intervention Type: DEVICE; Name: VV-ECCO2R to enable lower tidal volume mechanical ventilation; Assigned to Arm(s): ECCO2R to enable lower tidal volume mechanical ventilation
D: Arm Label: ECMO Facilitated Resuscitation; Type: EXPERIMENTAL; Interventions: Device: Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation | Arm Label: Standard ACLS Resuscitation; Type: OTHER; Interventions: Device: Standard Advanced Cardiac Life Support (ACLS) Resuscitation | Intervention Type: DEVICE; Name: Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation; Assigned to Arm(s): ECMO Facilitated Resuscitation | Intervention Type: DEVICE; Name: Standard Advanced Cardiac Life Support (ACLS) Resuscitation; Assigned to Arm(s): Standard ACLS Resuscitation

Answer: C