Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Obstructive Sleep Apnea in WTC Responders: Role of Nasal Pathology
Brief Summary: The goal of the study is to examine the possible underlying causes of sleep apnea (a disorder in which there are problems with breathing during sleep) in World Trade Center Responders. The study will look at the relationship between sleep apnea and various nose and throat conditions. Specifically, the study will look at upper airway disease (problems with the nose and throat), nasal inflammation, and nasal resistance (the amount of airflow through the nose). Subjects will have a physical exam and answer questions about nasal symptoms and sleeping problems. Nasal lavage (washing the inner nasal passages) will be performed on the subjects and markers of inflammation will be measured in the lavage fluid. Rhinomanometry (measuring the airflow through the nose) will also be performed to measure the degree of airflow obstruction. All subjects will be asked to perform in-home sleep apnea monitoring. Those subjects who are diagnosed with sleep apnea will test two treatment methods. Sleep apnea is treated by using a CPAP (continuous positive airway pressure) device. This device blows air into a mask worn by the patient during sleep. The two treatment methods that will be tested are the fixed pressure CPAP (pressure is constant during use) and CPAP-flex (pressure decreases when the subject exhales). Patients will be randomly assigned to one treatment method for one month then crossed to the other treatment method for the next month. The investigators will determine if patients with certain nasal conditions (high nasal resistance) are more likely to use CPAP-flex rather than CPAP.


Options:
A: Arm Label: Fixed CPAP; Type: EXPERIMENTAL; Interventions: Device: Fixed CPAP | Arm Label: Auto-adjusting CPAP; Type: ACTIVE_COMPARATOR; Interventions: Device: Auto-adjusting CPAP | Intervention Type: DEVICE; Name: Fixed CPAP; Assigned to Arm(s): Fixed CPAP | Intervention Type: DEVICE; Name: Auto-adjusting CPAP; Assigned to Arm(s): Auto-adjusting CPAP
B: Arm Label: Auto Aflex; Type: ACTIVE_COMPARATOR; Interventions: Device: Auto AFlex | Arm Label: Auto CPAP; Type: ACTIVE_COMPARATOR; Interventions: Device: Auto CPAP | Arm Label: CPAP; Type: ACTIVE_COMPARATOR; Interventions: Device: CPAP | Intervention Type: DEVICE; Name: Auto AFlex; Assigned to Arm(s): Auto Aflex | Intervention Type: DEVICE; Name: Auto CPAP; Assigned to Arm(s): Auto CPAP | Intervention Type: DEVICE; Name: CPAP; Assigned to Arm(s): CPAP
C: Arm Label: Standard CPAP; Type: ACTIVE_COMPARATOR; Interventions: Device: Standard CPAP | Arm Label: CPAP - Flex; Type: ACTIVE_COMPARATOR; Interventions: Device: CPAP - Flex | Intervention Type: DEVICE; Name: Standard CPAP; Assigned to Arm(s): Standard CPAP | Intervention Type: DEVICE; Name: CPAP - Flex; Assigned to Arm(s): CPAP - Flex
D: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Device: life style modification, noninvasive ventilation, CPAP | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Device: life style modification, noninvasive ventilation, CPAP | Arm Label: 3; Type: ACTIVE_COMPARATOR; Interventions: Device: life style modification, noninvasive ventilation, CPAP | Arm Label: 4; Type: ACTIVE_COMPARATOR; Interventions: Device: life style modification, noninvasive ventilation, CPAP | Arm Label: 5; Type: ACTIVE_COMPARATOR; Interventions: Device: life style modification, noninvasive ventilation, CPAP | Intervention Type: DEVICE; Name: life style modification, noninvasive ventilation, CPAP; Assigned to Arm(s): 1, 2, 3, 4, 5

Answer: C