Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: N/A
Brief Summary: A randomized, double-blind trial of docosahexaenoic and arachidonic acid supplementation in breast-fed preterm infants

Background:

Docosahexaenoic acid (DHA) and arachidonic acid (AA) are essential for preterm infants. Human milk and preterm formulas contain DHA and AA, but at lower concentrations than required to approximate utero accretion rate.

Objective:

To evaluate the effect of a high dose DHA and AA supplement to breast-fed preterm infants in the early neonatal period. Primary endpoints are neurodevelopment at 6 and 20 months of age.

Design:

A randomized double-blind placebo-controlled study is carried out in four Norwegian neonatal centers.

Subjects and methods:

Infants with birth weight \< 1.5 kg are randomized to either an intervention or a control group. All infants receive fortified human milk, and a daily dose of 0.5 ml study oil per 100 ml milk. Infants in the intervention group receive oil with DHA and AA (Formulaid, Martek, USA), while the control oil contains vegetable oil without DHA or AA. Blood samples are collected at birth (cord), and at start and stop of the intervention. Plasma is analyzed for fatty acid pattern using high performance liquid chromatography.


Options:
A: Intervention Type: PROCEDURE; Name: Supplement of fatty acid (DHA and AA); Assigned to Arm(s): N/A
B: Arm Label: Commercially available infant formula A; Type: EXPERIMENTAL; Interventions: Other: Infant Formula milk based | Arm Label: Commercially available infant formula B; Type: ACTIVE_COMPARATOR; Interventions: Other: Infant formula milk based | Intervention Type: OTHER; Name: Infant Formula milk based; Assigned to Arm(s): Commercially available infant formula A | Intervention Type: OTHER; Name: Infant formula milk based; Assigned to Arm(s): Commercially available infant formula B
C: Arm Label: low docosahexaenoic acid formula; Type: EXPERIMENTAL; Interventions: Dietary Supplement: low docosahexaenoic acid formula | Arm Label: medium docosahexaenoic acid formula; Type: EXPERIMENTAL; Interventions: Dietary Supplement: medium docosahexaenoic acid formula | Arm Label: high docosahexaenoic acid formula; Type: EXPERIMENTAL; Interventions: Dietary Supplement: high docosahexaenoic acid formula | Arm Label: human milk; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: breast milk | Intervention Type: DIETARY_SUPPLEMENT; Name: low docosahexaenoic acid formula; Assigned to Arm(s): low docosahexaenoic acid formula | Intervention Type: DIETARY_SUPPLEMENT; Name: medium docosahexaenoic acid formula; Assigned to Arm(s): medium docosahexaenoic acid formula | Intervention Type: DIETARY_SUPPLEMENT; Name: high docosahexaenoic acid formula; Assigned to Arm(s): high docosahexaenoic acid formula | Intervention Type: DIETARY_SUPPLEMENT; Name: breast milk; Assigned to Arm(s): human milk
D: Arm Label: 1; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Docosahexaenoic acid (DHA) | Intervention Type: DIETARY_SUPPLEMENT; Name: Docosahexaenoic acid (DHA); Assigned to Arm(s): 2

Answer: A