Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase 1b Study to Evaluate the Safety and Immunogenicity of MEDI7510 in Older Adults
Brief Summary: The goal of this study is to evaluate the safety, tolerability and immunogenicity of ascending doses of adjuvant in combination with a single dosage level of RSV sF in adults 60 years or older who are healthy or who have stable, chronic underlying medical conditions. This study will also provide preliminary safety and immunogenicity data to support concurrent dosing of MEDI7510 with influenza vaccine (IIV), and to assess the safety of MEDI7510 at a dose previously assessed in the Phase 1a study.


Options:
A: Arm Label: MEDI7510 (120 mcg sF + 1 mcg GLA), Cohort 1; Type: EXPERIMENTAL; Interventions: Biological: MEDI7510 | Arm Label: MEDI7510 (120 mcg sF + 2.5 mcg GLA), Cohort 2; Type: EXPERIMENTAL; Interventions: Biological: MEDI7510, Biological: IIV | Arm Label: MEDI7510 (120 mcg sF + 5 mcg GLA), Cohort 3; Type: EXPERIMENTAL; Interventions: Biological: MEDI7510 | Arm Label: MEDI7510 (80 mcg sF + 2.5 mcg GLA), Cohort 4; Type: EXPERIMENTAL; Interventions: Biological: MEDI7510 | Arm Label: Inactivated Influenza Vaccine (IIV); Type: ACTIVE_COMPARATOR; Interventions: Biological: IIV | Intervention Type: BIOLOGICAL; Name: MEDI7510; Assigned to Arm(s): MEDI7510 (120 mcg sF + 1 mcg GLA), Cohort 1, MEDI7510 (120 mcg sF + 2.5 mcg GLA), Cohort 2, MEDI7510 (120 mcg sF + 5 mcg GLA), Cohort 3, MEDI7510 (80 mcg sF + 2.5 mcg GLA), Cohort 4 | Intervention Type: BIOLOGICAL; Name: IIV; Assigned to Arm(s): Inactivated Influenza Vaccine (IIV), MEDI7510 (120 mcg sF + 2.5 mcg GLA), Cohort 2
B: Arm Label: Group 1: DS-Cav1 (50 mcg); Type: EXPERIMENTAL; Interventions: Biological: VRC-RSVRGP084-00-VP | Arm Label: Group 2: DS-Cav1 (50 mcg) + alum; Type: EXPERIMENTAL; Interventions: Biological: VRC-RSVRGP084-00-VP, Other: Aluminum Hydroxide Suspension | Arm Label: Group 3: DS-Cav1 (150 mcg); Type: EXPERIMENTAL; Interventions: Biological: VRC-RSVRGP084-00-VP | Arm Label: Group 4: DS-Cav1 (150 mcg) + alum; Type: EXPERIMENTAL; Interventions: Biological: VRC-RSVRGP084-00-VP, Other: Aluminum Hydroxide Suspension | Arm Label: Group 5: DS-Cav1 (500 mcg); Type: EXPERIMENTAL; Interventions: Biological: VRC-RSVRGP084-00-VP | Arm Label: Group 6:DS-Cav1 (500 mcg) + alum; Type: EXPERIMENTAL; Interventions: Biological: VRC-RSVRGP084-00-VP, Other: Aluminum Hydroxide Suspension | Intervention Type: BIOLOGICAL; Name: VRC-RSVRGP084-00-VP; Assigned to Arm(s): Group 1: DS-Cav1 (50 mcg), Group 2: DS-Cav1 (50 mcg) + alum, Group 3: DS-Cav1 (150 mcg), Group 4: DS-Cav1 (150 mcg) + alum, Group 5: DS-Cav1 (500 mcg), Group 6:DS-Cav1 (500 mcg) + alum | Intervention Type: OTHER; Name: Aluminum Hydroxide Suspension; Assigned to Arm(s): Group 2: DS-Cav1 (50 mcg) + alum, Group 4: DS-Cav1 (150 mcg) + alum, Group 6:DS-Cav1 (500 mcg) + alum
C: Arm Label: RSV vaccine formulation 1 Group; Type: EXPERIMENTAL; Interventions: Biological: RSV vaccine GSK3003895A (formulation 1) | Arm Label: RSV vaccine formulation 2 Group; Type: EXPERIMENTAL; Interventions: Biological: RSV vaccine GSK3003898A (formulation 2) | Arm Label: RSV vaccine formulation 3 Group; Type: EXPERIMENTAL; Interventions: Biological: RSV vaccine GSK3003899A (formulation 3) | Arm Label: Boostrix Group; Type: ACTIVE_COMPARATOR; Interventions: Biological: Boostrix | Intervention Type: BIOLOGICAL; Name: RSV vaccine GSK3003895A (formulation 1); Assigned to Arm(s): RSV vaccine formulation 1 Group | Intervention Type: BIOLOGICAL; Name: RSV vaccine GSK3003898A (formulation 2); Assigned to Arm(s): RSV vaccine formulation 2 Group | Intervention Type: BIOLOGICAL; Name: RSV vaccine GSK3003899A (formulation 3); Assigned to Arm(s): RSV vaccine formulation 3 Group | Intervention Type: BIOLOGICAL; Name: Boostrix; Assigned to Arm(s): Boostrix Group
D: Arm Label: RSV group; Type: EXPERIMENTAL; Interventions: Biological: RSV vaccine GSK3003891A | Arm Label: Boostrix group; Type: ACTIVE_COMPARATOR; Interventions: Biological: Boostrix | Intervention Type: BIOLOGICAL; Name: RSV vaccine GSK3003891A; Assigned to Arm(s): RSV group | Intervention Type: BIOLOGICAL; Name: Boostrix; Assigned to Arm(s): Boostrix group

Answer: A