TrialPanorama/Dataset huggingface dataset:
Please select the outcome measures that correspond to the clinical trial below.
Title: Immunization Schedule Alert Platform: Determining ISAP SMS Efficacy in Improving Childhood Immunization Timeliness and Completeness in Nigeria
Brief Summary: The ISAP study is investigating the efficacy of SMS messages in improving routine childhood Immunization timeliness and completeness in Nigeria.


Options:
A: Postpartum Contraceptive Uptake (Through study completion, an average of six months); Skilled Birth (Through study completion, an average of six months); Immunisation (Through study completion, an average of six months)
B: Proportion of timely and complete vaccine uptake after ISAP SMS Intervention (12 months)
C: Count of Women Who Have Excess Gestational Weight Gain (Approximately 6 months (from 10-13 weeks gestation to 35-36 weeks gestation))
D: Self-reported adherence on antiretroviral therapy (12 months post-partum); Adherence on antiretroviral therapy (12 months post-partum); Adherence on antiretroviral therapy (infant) (12 months post-partum); Retention in care (12 months post-partum); Adherence on antiretroviral therapy (dried blood spots) (12 months post-partum)

Answer: B
Please select the outcome measures that correspond to the clinical trial below.
Title: Immunization Schedule Alert Platform: Determining ISAP SMS Efficacy in Improving Childhood Immunization Timeliness and Completeness in Nigeria
Brief Summary: The ISAP study is investigating the efficacy of SMS messages in improving routine childhood Immunization timeliness and completeness in Nigeria.


Options:
A: The proportion of women who successfully complete key PMTCT transition points from antenatal to six weeks postpartum. (~ 6 months); Initiation of Infant prophylaxis, Facility delivery and receipt of results of 6 weeks early infant diagnosis by DNA PCR (~ 6 months)
B: Biometrically confirmed abstinence (3-6 months); Quitline call rates (1-6 months); Knowledge as measured by survey items (1-6 months)
C: Proportion of timely and complete vaccine uptake after ISAP SMS Intervention (12 months)
D: Self-reported completion of a full course of PEP medications and receipt of a final HIV test result from their nPEP provider 12 weeks after the index exposure (12 weeks)

Answer: C
Please select the outcome measures that correspond to the clinical trial below.
Title: A Feasibility Randomised Controlled Study of an Innovative Postnatal Breastfeeding Peer Counselling Programme
Brief Summary: A feasibility study is proposed in the current study as women who had given birth to their first babies recruited to a previous project specifically expressed the need for postnatal breastfeeding support from peer counsellors at home and there is evidence that this could be of benefit for women and their infants. Evidence of whether women in Hong Kong who had peer counsellors have better breastfeeding outcomes compared to women who had standard care however is not available. Prior to undertaking a definitive trial, the investigators need to know if women would be willing to be recruited and randomised to an intervention or standard care.


Options:
A: Change in target behaviour: zinc use (six weeks post-intervention); Change in target behaviour: correct ORS preparation (six weeks post-intervention); Change in target behaviour: Exclusive breastfeeding (six weeks post-intervention); Change in target behaviour: Handwashing with soap (six weeks post-intervention)
B: Use of iron-folic acid supplements (IFA tablets used during 9 months of last pregnancy among recently delivered women with children <6 months of age by June 2016); Use of calcium supplements (Calcium tablets used during 9 months of last pregnancy among recently delivered women with children <6 months of age by June 2016); Dietary diversity during pregnancy (Pregnant women in second and third trimester of pregnancy (4-9 months) by June- August 2016); Dietary micronutrient intakes (Pregnant women in second and third trimester of pregnancy (4-9 months) by June- August 2016); Coverage of maternal nutrition intervention (1 year)
C: Number of Participants Completing Qualitative Interviews on the Peer Counselling Breastfeeding Intervention (through study completion, an average of 6 months)
D: Maternal stress and anxiety (Baselibne to 12 weeks); Breast milk volume at 12 weeks assessed non-invasively using stable isotope techniques (12 weeks); Breast milk cortisol concentrations at 12 weeks (12 weeks); Infant behaviour measured using a 3-day diary at 12 weeks (12 weeks); Infant weight and body composition measured using stable isotopes at 12 weeks (12 weeks); Physiological changes (maternal saliva cortisol, breast milk cortisol and milk volume) before and after physiological-mini test in intervention group at 2,6 and 12 weeks. (2,6,12 weeks)

Answer: C
Please select the outcome measures that correspond to the clinical trial below.
Title: Effectiveness of PGT-A by Using IVF Versus ICSI for Non-male Factor Infertility: a Pilot Study
Brief Summary: The investigators want to investigate if the use of conventional in vitro fertilization (IVF) can generate more euploid embryos as compared to intracytoplasmic sperm injection (ICSI).

To verify this, the investigators will inject half of the oocytes by ICSI and the other half of the oocytes will be inseminated by conventional IVF. The most important aim is to see if IVF is able to generate more euploid embryos.


Options:
A: Ongoing pregnancy resulting in live birth after the first embryo transfer of the started treatment cycle. (At 12 weeks of gestation)
B: Ongoing pregnancy leading to live birth after the first cycle with embryo transfer (After 22 weeks of gestation)
C: Cumulative live birth rate from first live birth episode of a study cycle (Minimum follow-up time is one year after inclusion)
D: Ploidy state: euploid or aneuploid (7 days)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Effect of Two add-on Software Interventions for Improving Hand Washing and Sanitation in Rural Tanzania: an Impact Evaluation
Brief Summary: BACKGROUND. Diarrhea is ubiquitous, particularly among people in low- and middle-income countries. Unsafe drinking water, poor sanitation, and insufficient hygiene are responsible for nearly 90% of diarrhea-related mortalities. Despite extensive knowledge that has been obtained in recent years, there is no consensus as to the most efficacious approach to improve Water, Sanitation, and Hygiene behavior and health. With this study, we want to determine whether multi-faceted contextualized and non-contextualized WASH interventions have a differential impact.

OBJECTIVES. The primary objective is to determine the effectiveness of a contextualized and non-contextualized add-on intervention for improving hand washing (HW) behavior. Secondary objectives include the impact on latrine use, health, coverage of HW and latrine infrastructure, quality of life, and cost-effectiveness.


Options:
A: Reported diarrhoea in children <5 years (7-day recall, assessed 4 times during 3-month follow-up rounds)
B: Length-for-Age Z-scores (Measured 24 months after intervention); Diarrhea Prevalence (Measured 12 and 24 months after intervention)
C: Change in hand washing behavior (The outcome is measured at baseline, and after 1 and 2 years of intervention. In addition, a measurement will occur 1 year after the intervention has finished to see whether improvements have been maintained.)
D: Combined prevalence of bacterial and protozoan enteric infections (12 month follow-up)

Answer: C
Please select the outcome measures that correspond to the clinical trial below.
Title: Computer Assisted Family Intervention to Treat Self- Harm Disparities in Latinas and Sexual/Gender Minority Youth (CA CIFFTA)
Brief Summary: This study is designed to refine and test the efficacy of a computer assisted culturally informed and flexible/adaptive intervention for Latino adolescents for whom self-harm behaviors are a health disparity-specifically, Latinas and sexual/gender minority youth.


Options:
A: Change From Baseline in Scores on the Patient Health Questionnaire (PHQ-9) Scale at Week 6 (Baseline, Week 1, Week 2, Week 3, Week 4, Week 5)
B: Columbia Suicide Severity Rating Scale (CSSRS) Suicide Ideation (Baseline, 4 months post baseline, 12 months post baseline)
C: Client Satisfaction Questionnaire (Immediately following Brief Intervention)
D: Change on the severity of borderline personality disorder measured by Borderline Personality Symptom List (BSL-23). (Baseline and up to 12 months after inclusion.)

Answer: B
Please select the outcome measures that correspond to the clinical trial below.
Title: Computer Assisted Family Intervention to Treat Self- Harm Disparities in Latinas and Sexual/Gender Minority Youth (CA CIFFTA)
Brief Summary: This study is designed to refine and test the efficacy of a computer assisted culturally informed and flexible/adaptive intervention for Latino adolescents for whom self-harm behaviors are a health disparity-specifically, Latinas and sexual/gender minority youth.


Options:
A: Columbia Suicide Severity Rating Scale (CSSRS) Suicide Ideation (Baseline, 4 months post baseline, 12 months post baseline)
B: Beck scale for suicidal ideation (six months)
C: Reduced Self-harm (3 months)
D: Clinical changes after 16 sessions of Dialectical Behavioral Therapy. (4 months); Neural changes after 16 sessions of Dialectical Behavioral Therapy. (4 months); Neuropsychological changes after 16 sessions of Dialectical Behavioral Therapy. (4 months)

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: Cold Therapy for Pain Control Following Caesarean Section at Erlanger Baroness Hospital
Brief Summary: Cold Therapy has been used for a variety of procedures and has been studied in several but not recently studied for reducing postop pain following Caesarean Sections. The hypothesis is that Cold Therapy will reduce postop pain and increase patients mobility and improve care of her newborn.


Options:
A: Intensity of pain after cesarean (after TENS application)
B: pain, to be evaluated using a numerical rating score (NRS) on a 100mm scale (0= no pain whatsoever, 100 = unbearable pain). (4 weeks)
C: Pain score by visual analogue scale (VAS) on movement at 48 hours postoperatively (48 hours)
D: Post Operative Pain (48 hours after surgery)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: A Multicenter, Randomized, Placebo-controlled, Parallel-arm Study to Investigate the Efficacy, Pharmacokinetics, and Safety of CSL312 in Subjects With Hereditary Angioedema
Brief Summary: This is a multicenter, randomized, placebo-controlled, parallel-arm, phase 2 study to investigate the clinical efficacy, pharmacokinetics, and safety of CSL312 as prophylaxis to prevent attacks in subjects with HAE.


Options:
A: Number of HAE Attacks (28 days)
B: The Mean Time Normalized Number of HAE Attacks Per Month in Subjects With C1-INH HAE During Treatment Period 1 (13 weeks)
C: Rate of Investigator Confirmed Hereditary Angioedema (HAE) Attacks During Treatment Period (From Day 0 to Day 182)
D: Part 1: The Rate of Expert-confirmed HAE Attacks During Dosing in the Entire 24-week Treatment Period (Day 1 to Day 168) (24 weeks); Part 2: To Evaluate the Long-term Safety and Tolerability of Berotralstat 110 and 150 mg in Subjects With HAE (Part 1: 24 weeks (Week 0 to 24 to 52), Part 2: 28 weeks (Week 24 to 52)); Part 3: To Evaluate the Long-term Safety and Tolerability of Berotralstat Administered QD Over a 52- to up to 104-week Administration Period in Subjects With HAE. (Part 3: Week 52 to up to Week 104.)

Answer: B
Please select the outcome measures that correspond to the clinical trial below.
Title: Prospective, Multicentre Trial to Assess the Diagnostic Accuracy of the Truenat Assays at Intended Settings of Use
Brief Summary: Consenting adults presenting with signs and symptoms compatible with pulmonary tuberculosis will be interviewed for demographic and medical information, and then will be asked to provide 3-4 expectorated sputum specimens. In the study laboratory, sputa will be tested using conventional and investigational diagnostic tests for tuberculosis and rifampin resistance.


Options:
A: Treatment time (Up to 8 weeks)
B: Treatment time (Up to 8 weeks)
C: Time to TB treatment initiation (8 weeks follow up)
D: Diagnostic accuracy (Sensitivity and Specificity) of the Truenat MTB assay (Day 1)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Prospective, Multicentre Trial to Assess the Diagnostic Accuracy of the Truenat Assays at Intended Settings of Use
Brief Summary: Consenting adults presenting with signs and symptoms compatible with pulmonary tuberculosis will be interviewed for demographic and medical information, and then will be asked to provide 3-4 expectorated sputum specimens. In the study laboratory, sputa will be tested using conventional and investigational diagnostic tests for tuberculosis and rifampin resistance.


Options:
A: Number of MDR TB Cases Amongst New TB Cases and Previously Treated TB Cases (2 months after enrollment)
B: Treatment time (Up to 8 weeks)
C: Diagnostic accuracy (Sensitivity and Specificity) of the Truenat MTB assay (Day 1)
D: Treatment time (Up to 8 weeks)

Answer: C
Please select the outcome measures that correspond to the clinical trial below.
Title: Prospective, Multicentre Trial to Assess the Diagnostic Accuracy of the Truenat Assays at Intended Settings of Use
Brief Summary: Consenting adults presenting with signs and symptoms compatible with pulmonary tuberculosis will be interviewed for demographic and medical information, and then will be asked to provide 3-4 expectorated sputum specimens. In the study laboratory, sputa will be tested using conventional and investigational diagnostic tests for tuberculosis and rifampin resistance.


Options:
A: Estimate the diagnostic accuracy of the Xpert MTB/XDR assay for INH and ETH resistance detection (Day 1); Estimate the diagnostic accuracy of the Xpert MTB/XDR assay for fluoroquinolone resistance detection (Day 1); Estimate the diagnostic accuracy of the Xpert MTB/XDR assay for second-line injectable resistance detection (Day 1)
B: Retention in care with viral suppression (48 weeks after HIV testing)
C: increase TB case detection (6 months)
D: Diagnostic accuracy (Sensitivity and Specificity) of the Truenat MTB assay (Day 1)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Prospective, Multicentre Trial to Assess the Diagnostic Accuracy of the Truenat Assays at Intended Settings of Use
Brief Summary: Consenting adults presenting with signs and symptoms compatible with pulmonary tuberculosis will be interviewed for demographic and medical information, and then will be asked to provide 3-4 expectorated sputum specimens. In the study laboratory, sputa will be tested using conventional and investigational diagnostic tests for tuberculosis and rifampin resistance.


Options:
A: Diagnostic accuracy (Sensitivity and Specificity) of the Truenat MTB assay (Day 1)
B: Retention in care with viral suppression (48 weeks after HIV testing)
C: Treatment time (Up to 8 weeks)
D: increase TB case detection (6 months)

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: Prospective, Multicentre Trial to Assess the Diagnostic Accuracy of the Truenat Assays at Intended Settings of Use
Brief Summary: Consenting adults presenting with signs and symptoms compatible with pulmonary tuberculosis will be interviewed for demographic and medical information, and then will be asked to provide 3-4 expectorated sputum specimens. In the study laboratory, sputa will be tested using conventional and investigational diagnostic tests for tuberculosis and rifampin resistance.


Options:
A: increase TB case detection (6 months)
B: Treatment time (Up to 8 weeks)
C: Tuberculosis diagnostic algorithm (3 years)
D: Diagnostic accuracy (Sensitivity and Specificity) of the Truenat MTB assay (Day 1)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Prospective, Multicentre Trial to Assess the Diagnostic Accuracy of the Truenat Assays at Intended Settings of Use
Brief Summary: Consenting adults presenting with signs and symptoms compatible with pulmonary tuberculosis will be interviewed for demographic and medical information, and then will be asked to provide 3-4 expectorated sputum specimens. In the study laboratory, sputa will be tested using conventional and investigational diagnostic tests for tuberculosis and rifampin resistance.


Options:
A: Retention in care with viral suppression (48 weeks after HIV testing)
B: Diagnostic accuracy (Sensitivity and Specificity) of the Truenat MTB assay (Day 1)
C: TB diagnostic sensitivity among adults (>12 years old). Sensitivity proportions will be estimated using laboratory data on TB diagnoses (see "Description" below). (Patients will be followed for an average of about 6 months each, and TB diagnostic sensitivity will be estimated at each clinical visit where the patient tests culture-positive for TB, with clinic visits occuring every one to 3 months.); All-cause mortality (Patients will be followed for an average of about 6 months each, with vital status assessed across the 6 month follow-up period.)
D: Correlation between baseline clinical characteristics and presence of microbiologically confirmed active tuberculosis. (Two years); Comparison of ART outcome in patients taking concomitant anti-tuberculosis therapy and those only taking ART. (Three years)

Answer: B
Please select the outcome measures that correspond to the clinical trial below.
Title: Prospective, Multicentre Trial to Assess the Diagnostic Accuracy of the Truenat Assays at Intended Settings of Use
Brief Summary: Consenting adults presenting with signs and symptoms compatible with pulmonary tuberculosis will be interviewed for demographic and medical information, and then will be asked to provide 3-4 expectorated sputum specimens. In the study laboratory, sputa will be tested using conventional and investigational diagnostic tests for tuberculosis and rifampin resistance.


Options:
A: Point estimates of sensitivity and specificity of FujiLAM, with 95% confidence intervals, using the defined eMRS. (Day 1); Point estimates of sensitivity and specificity of FujiLAM, with 95% confidence intervals, using the defined CRS. (Day 1); Diagnostic yield, with 95% confidence interval, of FujiLAM test among eMRS positive patients and AlereLAM, Smear and Ultra (sputum, urine) as comparators (on Day 1 specimens). (Day 1)
B: Retention in care with viral suppression (48 weeks after HIV testing)
C: Diagnostic accuracy (Sensitivity and Specificity) of the Truenat MTB assay (Day 1)
D: Time to TB treatment initiation (8 weeks follow up)

Answer: C
Please select the outcome measures that correspond to the clinical trial below.
Title: Stockholm Preterm Interaction-Based Intervention
Brief Summary: Extreme premature Children will at discharge from Karolinska Hospital and Södersjukhuset in Stockholm be asked to participate in a study, examining the effects of a home-visit based post-discharge program aiming at facilitating the interaction between infants and parents, improving the development of the children, and the parental mental health. The study is a randomized controlled Trial (RCT), hence 50% of the participants will be offered treatment as usual (TAU) with addition of an extended follow-up program. The interaction-based program consists of one initial visit at the hospital followed by nine home-visits and two telephone calls during the child's first year of life. The interventionists are skilled Healthcare professionals with several years of experience from caring for premature infants and their parents. All interventionists have successfully completed a one year further education program, delivered one day per week and containing theoretical lectures, practice with actual cases, supervision on the cases, visits to the different parts of the neonatal care chain and discussions with a representative from the premature family association Sweden.


Options:
A: Parent-child interaction (12 months corrected age.)
B: Index of Multisensory Processing (IMP) (At enrollment up to 36 weeks gestation (prior to intervention), and at intervention completion up to 42 weeks gestation)
C: Motor Development. (18 Months)
D: Bonding between primary caregiver and infant (6 months)

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: WhatsApp Embedded in Routine Service Delivery for Smoking Cessation: Effects on Success Rates in a Randomized Controlled Study
Brief Summary: Background: Recently, the use of communication technologies and social media applications has become increasingly widespread to strengthen efforts for smoking cessation. The purpose of this study is; to assess the effect on success rate of the WhatsApp application which is embedded in the smoking cessation policlinic service delivery.

Materials and Methods: A randomized controlled intervention study was conducted with 132 volunteers who were followed up at the EUTF Smoking Cessation Policlinic between March-July 2017. The intervention content based on transtheoretic model was prepared and 60 WhatsApp messages were delivered to participants for 3 months of follow up. For data collection, initial interview form and follow up form consisting sociodemographic characteristics, smoking status, medical condition and treatment, were used. The success rate at first and third months were assessed by the point-prevalence regarding the previous week. Intention-to-treat analysis was used. For secondary outcomes; number of follow-ups, change in weight and continuity of medication were evaluated.

Findings: Success rate in the first month was 65.9% for intervention group and 40.9% in the control group; for the third month it was 50.0% in the intervention group and 30.7% in the control group. Being in the intervention group increased the success rate by 3,50 (1,30-9,44) times in the first month and 2,50 (1,08-6,40) times in the third month. The intervention was the only parameter effective in the two follow-up periods; the difference in success rate caused by gender, marital status and work-related social class has been eliminated after adjustment for the intervention.


Options:
A: Self-reported continuous abstinence of smoking and exhaled carbon monoxide levels less than 10 ppm as measured and recorded by the research nurse at weeks 12 and 52. (1 year)
B: Smoking abstinence assessed by self-reported and biochemically verified by salivary cotinine (6 months)
C: Participant smoking status. (6 and 12 month follow-up)
D: Quitting success rates at the end of the 1st, 3rd and 6th month (6 months)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Indian Postpartum Care: A-randomised Trial to Improve Maternal Health Six Weeks After Birth
Brief Summary: After the child birth most women experience major health issues such as depression, severe fatigue, back pain, perineal pain, mastitis, urinary or faecal incontinence, sexual problems and relationship problems with partners. That all lead to poorer emotional and mental health and factors contributing isolation, exhaustion and physical health problems.

'Sava Mahina (6-week period) is a traditional practice for postpartum women in India, which include special diet, lifestyle and supportive care. The current multicenter randomized controlled trial (RCT) aims to evaluate outcomes of Indian postpartum care on women.


Options:
A: Number of Participants With Combined Common Mental Disorders (CMDs, i.e. Anxiety and Depression). (6 weeks postpartum)
B: Number of significantly improved child and maternal outcomes (2 Years)
C: Parents breastfeeding self efficacy (7 days post partum)
D: Change in Post-natal depression (6 weeks following child birth)

Answer: D