Please select the eligibility criteria that correspond to the clinical trial below.
Title: A Double-Blind, Phase 3, Two-Week, Placebo Controlled Study of Methylnaltrexone(MNTX) for the Relief of Constipation Due to Opioid Therapy in Advance Medical Illness.
Brief Summary: To determine the efficacy of subcutaneous MNTX to relieve opioid-induced constipation in patients with advanced medical illness.


Options:
A: Inclusion Criteria:

* Histologically or cytologically confirmed neoplasm
* 18 years of age or older
* Have received opioids for analgesia for at least 2 weeks and been on a stable regimen of opioids and laxatives for 3 or more days before study entry
* Fewer than three laxation during the preceding week and no laxation within 24 hours before study entry, or no laxation within 48 hours before study entry
* Life expectancy of at least 6 months
* World Health Organization Performance Status 0-3
* Women of childbearing potential must have a negative pregnancy test
* Breastfeeding should be discontinued prior to study entry
* Ability to understand and the willingness to sign a written informed consent document.
* Laboratory values within a week of study entry:

Absolute neutrophil count \> 1,500/microliter Hemoglobin \> 7 g/dL Platelet count \> 100,000/microliter Calculated calcium \< 10.5 mg/dL Calculated creatinine clearance \> 30 mg.min Alanine aminotransferase \< 3 x upper limit of normal (ULN) Aspartate aminotransferase \< 3 x ULN Alkaline phosphatase \< 2.5 x ULN Bilirubin \< 1.5 x ULN

Exclusion Criteria:

* Constipation not primarily caused by opioids, such as mechanical gastrointestinal obstruction or ongoing vinca alkaloid administration
* Indwelling peritoneal catheter
* Clinically active diverticular disease
* Fecal impaction
* Acute surgical abdomen
* Fecal ostomy
* Peritoneal carcinomatosis
* Known hypersensitivity to methylnaltrexone, naltrexone, or naloxone
* Administration of any investigational drug or experimental product within the previous 30 days
* Initiation of a new bowel regimen or prokinetic agents within a week of study entry
B: Inclusion Criteria:

* 18 years of age and older
* Negative pregnancy test (serum or urine) at screening for all women of childbearing potential
* Advanced Medical Illness (i.e., terminal illness, such as incurable cancer or end of stage AIDS) with life expectancy of ≥ 1 month
* patient must sign ICF

Exclusion Criteria:

* Women who are pregnant and/or nursing
* Previous treatment with MNTX
* Participation in any other studies involving investigational products within 30 days prior to screening
C: Inclusion Criteria:

* Patient is receiving a minimum total daily dose of 30 mg of oral morphine, or equianalgesic amount\[s\] of 1 or more other opioid therapies, for a minimum of 4 weeks for chronic pain or cancer relate pain Presence of OIC in the past 2 weeks

  * (for cancer patients only) Patient has a current diagnosis of cancer that is not currently in remission and has cancer-related pain Internet access and is able and willing to complete a longitudinal web-based survey
  * Patient is able to understand and comply with the requirements of the study, as judged by the investigator (includes ability to read and write and to use

Exclusion Criteria:

* Patient is unable or refuses to provide informed consent;

  * Patient does not have access to a computer with internet connectivity, or is unable to use a computer to complete the web-based survey; Based on clinical judgment, patient has a history of chronic constipation (i.e. clinical diagnosis, note in the medical record, or patient history);
  * Patient has a history of (or current) colon cancer (primary or metastatic) (i.e., clinical diagnosis Patient has received an investigational medication to treat constipation or participated in any study involving investigational compound naloxegol within ≤90 days prior to the baseline visit
D: Inclusion criteria:

Patients enrolled in the study are patients who

* are eligible for Targinact® treatment according to the Targinact® SPC AND
* who have previously been treated with WHO step 1, 2 or 3 analgesics

Exclusion criteria are based on the Targinact® SPC.

Answer: B