Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Carbon Dioxide, Oxygen and Mean Arterial Pressure After Cardiac Arrest and Resuscitation - Targeting High vs. Low Normal Values
Brief Summary: The COMACARE trial is a pilot multicenter randomized trial to assess the feasibility and effect on brain injury markers of targeting low or high normal arterial oxygen tension (PaO2), arterial carbon dioxide tension (PaCO2) and mean arterial pressure (MAP) in comatose, mechanically ventilated patients after out-of-hospital cardiac arrest. Using factorial design, participants are randomized at admission to intensive care unit to one of eight groups targeting either low or high normal values of PaO2, PaCO2 and MAP for 36 h. In this way, investigators will be assessing the feasibility and effect of all three variables at the same time.

The primary outcome is serum concentration of neuron-specific enolase (NSE) at 48 h after cardiac arrest. Feasibility outcome is between-group separation in PaO2, PaCO2 and MAP levels. Secondary outcomes include continuous monitoring of cerebral oxygenation, EEG and ECG for 48 h, the levels of NSE, S100B and cardiac troponin at randomization and 24, 48 and 72 h after cardiac arrest and neurological assessment at 6 months after cardiac arrest.


Options:
A: Arm Label: Liberal Oxygenation (LO) group; Type: ACTIVE_COMPARATOR; Interventions: Drug: Modulation of Inspired Fraction of Oxygen (FiO2) | Arm Label: Conservative Oxygenation (CO) group; Type: EXPERIMENTAL; Interventions: Drug: Modulation of Inspired Fraction of Oxygen (FiO2) | Intervention Type: DRUG; Name: Modulation of Inspired Fraction of Oxygen (FiO2); Assigned to Arm(s): Conservative Oxygenation (CO) group, Liberal Oxygenation (LO) group
B: Arm Label: Liberal oxygen; Type: ACTIVE_COMPARATOR; Interventions: Drug: Liberal Oxygen | Arm Label: Titrated oxygen; Type: EXPERIMENTAL; Interventions: Drug: Titrated Oxygen | Intervention Type: DRUG; Name: Titrated Oxygen; Assigned to Arm(s): Titrated oxygen | Intervention Type: DRUG; Name: Liberal Oxygen; Assigned to Arm(s): Liberal oxygen
C: Arm Label: High-normal PaO2; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oxygen | Arm Label: Low-normal PaO2; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oxygen | Intervention Type: DRUG; Name: Oxygen; Assigned to Arm(s): High-normal PaO2, Low-normal PaO2
D: Arm Label: Group 1; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: Low normal PaO2, Other: Low normal MAP | Arm Label: Group 2; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: Low normal PaO2, Other: Low normal MAP | Arm Label: Group 3; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: High normal PaO2, Other: Low normal MAP | Arm Label: Group 4; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: High normal PaO2, Other: Low normal MAP | Arm Label: Group 5; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: Low normal PaO2, Other: High normal MAP | Arm Label: Group 6; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: Low normal PaO2, Other: High normal MAP | Arm Label: Group 7; Type: ACTIVE_COMPARATOR; Interventions: Other: Low normal PaCO2, Other: High normal PaO2, Other: High normal MAP | Arm Label: Group 8; Type: ACTIVE_COMPARATOR; Interventions: Other: High normal PaCO2, Other: High normal PaO2, Other: High normal MAP | Intervention Type: OTHER; Name: Low normal PaCO2; Assigned to Arm(s): Group 1, Group 3, Group 5, Group 7 | Intervention Type: OTHER; Name: High normal PaCO2; Assigned to Arm(s): Group 2, Group 4, Group 6, Group 8 | Intervention Type: OTHER; Name: Low normal PaO2; Assigned to Arm(s): Group 1, Group 2, Group 5, Group 6 | Intervention Type: OTHER; Name: High normal PaO2; Assigned to Arm(s): Group 3, Group 4, Group 7, Group 8 | Intervention Type: OTHER; Name: Low normal MAP; Assigned to Arm(s): Group 1, Group 2, Group 3, Group 4 | Intervention Type: OTHER; Name: High normal MAP; Assigned to Arm(s): Group 5, Group 6, Group 7, Group 8

Answer: D