Please select the eligibility criteria that correspond to the clinical trial below.
Title: Impact of Intensive Exercise Training Compared to Inactive Controls on Coronary Collateral Circulation and Plaque Composition in Patients With Significant Stable Coronary Artery Disease
Brief Summary: Exercise training in patients with coronary artery disease is able to correct several risk factors. Furthermore endothelial function can be improved.

There are some hinds for improved collateral circulation after exercise training, nevertheless there is no study showing significant improvement/ increase in coronary collaterals. This might be due to technique of collateral measurement. Therefore we conduct a study were coronary blod flow before and after 4 weeks of exercise training were measured.


Options:
A: Inclusion Criteria:

* Patients of all ages with CHD verified by MI and/or Percutaneous Coronary Intervention (PCI) and/or coronary artery by-pass surgery (CABG) within 12 months before planned start of the intervention.
* Patients should be stable regarding their cardiac conditions and have optimised cardiac medication not substantially changed during the last month, completed heart school in hospital care (if applicable), listed at one of five specific primary health care centres agreed to join the project at time of inclusion.

Exclusion Criteria:

* Planned CABG or other causes demanding continued cardiologist care; e.g. on-going contact with heart failure clinic due to drug titration or investigations e.g. myocardial scintigraphy to detect ischemia before a new PCI
* Life expectancy ≤ 1 year, documented psychiatric disease that render difficulties to cooperate with other people or obvious abuse of alcohol or narcotics.
* Patients will also be excluded if they are unable to communicate or read the Swedish language and if they participate in other studies affecting the results.
B: Inclusion Criteria:

* informed consent
* age ≥70 years old
* hospital admission for acute coronary syndrome
* coronary artery angiography and successfully percutaneous coronary revascularization
* result of the short physical performance battery test at the inclusion visit between 4 and 9

Exclusion Criteria:

* chronic heart failure (new york heart association classification III-IV)
* left ventricle ejection fraction \<30%.
* severe aortic or mitral valvulopathy
* three vessel coronary artery disease or left main coronary artery disease requiring surgical coronary revascularization
* need of staged percutaneous coronary intervention
* severe cognitive impairment (defined as short portable mental status questionnaire \< 4)
* physical limitation/impairment not permitting physical activity training annd program
* life expectancy \<12 months
C: Inclusion Criteria:

* stable CAD
* min.1 coronary artery stenosis \>50%
* patient is symptomatic ( CCS 1-3)or has documented myocardial ischemia during stress test
* angina threshold \>75 Watt
* informed consent

Exclusion Criteria:

* Age \<18 oder \>75
* akut coronary syndrome within 2 weeks
* LV-EF \< 40 %
* significant valve diseases
* reduced patient compliance
* muscular disorder
* bronchial asthma or COLD stadium III and IV
D: Inclusion Criteria:

* History of coronary artery disease with or without intervention (PCI/CABG/conservative)
* History of a cardiac rehabilitation (CR) program
* Clinically stable without inducible ischemia or high risk ventricular arrhythmia, confirmed by the last available maximal ergospirometry test
* Age ≥18 years
* Willing and physically able to follow an app based telerehabilitation program and other study procedures in a four months follow-up period
* Evidence of a personally signed and dated informed consent, indicating that the subject (or legally-recognised representative) has been informed of all pertinent aspects of the study
* Possession of and/or able to use an Android smartphone
* Dutch speaking and understanding

Exclusion Criteria:

* Recent PCI or CABG procedure, and still included in a CR program
* Orthopedic, neurologic or any other pathologic condition which makes the patient physically unable to follow an app based telerehabilitation program
* Planned interventional procedure or surgery in the next four months
* Pregnant females
* Present cardiovascular complaints
* Participation in other cardiac rehabilitation program trials, focusing on exercise outcome
* Any condition which in the opinion of the investigator would make it unsafe or unsuitable for the patient to participate in this study or a life expectancy of less than 4 months based on investigators judgement

Answer: C