Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Active-control, Double-blind, Double-dummy Study to Evaluate the Efficacy and Safety of Tafenoquine for the Treatment of Plasmodium Vivax in Adults
Brief Summary: This Phase II study is designed to determine whether a single 600 mg dose or 400mg/day for 3 days of tafenoquine is efficacious, and well tolerated for clearing P. vivax malaria infection (blood schizontocidal and gametocytocidal activity) and preventing P. vivax relapse (hypnozoite eradication). It will also further establish the safety and tolerability of these doses of tafenoquine.


Options:
A: Arm Label: Tafenoquine 300 milligram (mg) single dose; Type: EXPERIMENTAL; Interventions: Drug: Tafenoquine 150 mg | Arm Label: Matched Placebo 300mg single dose; Type: PLACEBO_COMPARATOR; Interventions: Drug: Matched placebo 150mg | Intervention Type: DRUG; Name: Tafenoquine 150 mg; Assigned to Arm(s): Tafenoquine 300 milligram (mg) single dose | Intervention Type: DRUG; Name: Matched placebo 150mg; Assigned to Arm(s): Matched Placebo 300mg single dose
B: Arm Label: Tafenoquine+ Chloroquine; Type: EXPERIMENTAL; Interventions: Drug: Tafenoquine, Drug: Chloroquine, Drug: Primaquine Placebo | Arm Label: Primaquine+ Chloroquine; Type: EXPERIMENTAL; Interventions: Drug: Tafenoquine Placebo, Drug: Chloroquine, Drug: Primaquine | Intervention Type: DRUG; Name: Tafenoquine; Assigned to Arm(s): Tafenoquine+ Chloroquine | Intervention Type: DRUG; Name: Tafenoquine Placebo; Assigned to Arm(s): Primaquine+ Chloroquine | Intervention Type: DRUG; Name: Chloroquine; Assigned to Arm(s): Primaquine+ Chloroquine, Tafenoquine+ Chloroquine | Intervention Type: DRUG; Name: Primaquine; Assigned to Arm(s): Primaquine+ Chloroquine | Intervention Type: DRUG; Name: Primaquine Placebo; Assigned to Arm(s): Tafenoquine+ Chloroquine
C: Arm Label: Cohort 1 Tafenoquine; Type: EXPERIMENTAL; Interventions: Drug: Tafenoquine | Arm Label: Cohort 1-Chloroquine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Chloroquine + Primaquine | Arm Label: Cohort 2 Tafenoquine; Type: EXPERIMENTAL; Interventions: Drug: tafenoquine | Arm Label: Cohort 2 Chloroquine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Chloroquine + Primaquine | Intervention Type: DRUG; Name: Tafenoquine; Assigned to Arm(s): Cohort 1 Tafenoquine | Intervention Type: DRUG; Name: Chloroquine + Primaquine; Assigned to Arm(s): Cohort 1-Chloroquine | Intervention Type: DRUG; Name: tafenoquine; Assigned to Arm(s): Cohort 2 Tafenoquine | Intervention Type: DRUG; Name: Chloroquine + Primaquine; Assigned to Arm(s): Cohort 2 Chloroquine
D: Arm Label: Tafenoquine 50mg; Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Tafenoquine 50mg | Arm Label: Tafenoquine 100mg; Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Tafenoquine 100mg | Arm Label: Tafenoquine 300mg; Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Tafenoquine 300mg | Arm Label: Tafenoquine 600mg; Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Tafenoquine 600mg | Arm Label: Primaquine 15mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg, Drug: Primaquine 15mg | Arm Label: Chloroquine only; Type: PLACEBO_COMPARATOR; Interventions: Drug: Chloroquine 600mg, Drug: Chloroquine 300mg | Arm Label: Tafenoquine 300mg (Part 2); Type: EXPERIMENTAL; Interventions: Drug: Chloroquine 600mg (Part 2 ), Drug: Chloroquine 300mg (Part 2 ), Drug: Tafenoquine 300mg (Part 2) | Arm Label: Primaquine 15mg (Part 2); Type: ACTIVE_COMPARATOR; Interventions: Drug: Chloroquine 600mg (Part 2 ), Drug: Chloroquine 300mg (Part 2 ), Drug: Primaquine 15mg (Part2 ) | Arm Label: Chloroquine only (Part 2); Type: PLACEBO_COMPARATOR; Interventions: Drug: Chloroquine 600mg (Part 2 ), Drug: Chloroquine 300mg (Part 2 ) | Intervention Type: DRUG; Name: Chloroquine 600mg; Assigned to Arm(s): Chloroquine only, Primaquine 15mg, Tafenoquine 100mg, Tafenoquine 300mg, Tafenoquine 50mg, Tafenoquine 600mg | Intervention Type: DRUG; Name: Chloroquine 300mg; Assigned to Arm(s): Chloroquine only, Primaquine 15mg, Tafenoquine 100mg, Tafenoquine 300mg, Tafenoquine 50mg, Tafenoquine 600mg | Intervention Type: DRUG; Name: Tafenoquine 50mg; Assigned to Arm(s): Tafenoquine 50mg | Intervention Type: DRUG; Name: Tafenoquine 100mg; Assigned to Arm(s): Tafenoquine 100mg | Intervention Type: DRUG; Name: Tafenoquine 300mg; Assigned to Arm(s): Tafenoquine 300mg | Intervention Type: DRUG; Name: Tafenoquine 600mg; Assigned to Arm(s): Tafenoquine 600mg | Intervention Type: DRUG; Name: Primaquine 15mg; Assigned to Arm(s): Primaquine 15mg | Intervention Type: DRUG; Name: Chloroquine 600mg (Part 2 ); Assigned to Arm(s): Chloroquine only (Part 2), Primaquine 15mg (Part 2), Tafenoquine 300mg (Part 2) | Intervention Type: DRUG; Name: Chloroquine 300mg (Part 2 ); Assigned to Arm(s): Chloroquine only (Part 2), Primaquine 15mg (Part 2), Tafenoquine 300mg (Part 2) | Intervention Type: DRUG; Name: Tafenoquine 300mg (Part 2); Assigned to Arm(s): Tafenoquine 300mg (Part 2) | Intervention Type: DRUG; Name: Primaquine 15mg (Part2 ); Assigned to Arm(s): Primaquine 15mg (Part 2)

Answer: C