Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Treatment of Childhood Nasopharyngeal Carcinoma With Neoadjuvant Chemotherapy and Concomitant Chemoradiotherapy: A Groupwide Phase III Study
Brief Summary: This phase III trial is studying how well radiation therapy, amifostine, and chemotherapy work in treating young patients with newly diagnosed nasopharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs, such as amifostine, may protect normal cells from the side effects of radiation therapy. Drugs used in chemotherapy, such as cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with amifostine and chemotherapy may kill more tumor cells.


Options:
A: Arm Label: Intramuscular native E coli L-asparaginase (IM-EC); Type: ACTIVE_COMPARATOR; Interventions: Drug: asparaginase, Drug: cyclophosphamide, Drug: cytarabine, Drug: dexamethasone, Drug: dexrazoxane hydrochloride, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: leucovorin calcium, Drug: mercaptopurine, Drug: methotrexate, Drug: methylprednisolone, Drug: prednisolone, Drug: therapeutic hydrocortisone, Drug: vincristine sulfate, Radiation: radiation therapy | Arm Label: Intravenous PEG-asparaginase (IV-PEG); Type: EXPERIMENTAL; Interventions: Drug: cyclophosphamide, Drug: cytarabine, Drug: dexamethasone, Drug: dexrazoxane hydrochloride, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: leucovorin calcium, Drug: mercaptopurine, Drug: methotrexate, Drug: methylprednisolone, Drug: pegaspargase, Drug: prednisolone, Drug: therapeutic hydrocortisone, Drug: vincristine sulfate, Radiation: radiation therapy | Intervention Type: DRUG; Name: asparaginase; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC) | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: cytarabine; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: dexamethasone; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: dexrazoxane hydrochloride; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: etoposide; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: leucovorin calcium; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: mercaptopurine; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: methotrexate; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: methylprednisolone; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: pegaspargase; Assigned to Arm(s): Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: prednisolone; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: therapeutic hydrocortisone; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: DRUG; Name: vincristine sulfate; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG) | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): Intramuscular native E coli L-asparaginase (IM-EC), Intravenous PEG-asparaginase (IV-PEG)
B: Arm Label: Stratum I (radiotherapy, chemoprotective agent); Type: EXPERIMENTAL; Interventions: Drug: Amifostine, Other: Laboratory Biomarker Analysis, Radiation: Radiation Therapy | Arm Label: Stratum II (chemotherapy, chemoprotective agent, radiotherapy); Type: EXPERIMENTAL; Interventions: Drug: Amifostine, Drug: Cisplatin, Drug: Fluorouracil, Other: Laboratory Biomarker Analysis, Radiation: Radiation Therapy | Intervention Type: DRUG; Name: Amifostine; Assigned to Arm(s): Stratum I (radiotherapy, chemoprotective agent), Stratum II (chemotherapy, chemoprotective agent, radiotherapy) | Intervention Type: DRUG; Name: Cisplatin; Assigned to Arm(s): Stratum II (chemotherapy, chemoprotective agent, radiotherapy) | Intervention Type: DRUG; Name: Fluorouracil; Assigned to Arm(s): Stratum II (chemotherapy, chemoprotective agent, radiotherapy) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Stratum I (radiotherapy, chemoprotective agent), Stratum II (chemotherapy, chemoprotective agent, radiotherapy) | Intervention Type: RADIATION; Name: Radiation Therapy; Assigned to Arm(s): Stratum I (radiotherapy, chemoprotective agent), Stratum II (chemotherapy, chemoprotective agent, radiotherapy)
C: Arm Label: Exposed; Type: N/A; Interventions: N/A | Arm Label: Unexposed; Type: N/A; Interventions: N/A
D: Arm Label: asparaginase medac; Type: ACTIVE_COMPARATOR; Interventions: Drug: asparaginase | Arm Label: recombinant asparaginase; Type: EXPERIMENTAL; Interventions: Drug: recombinant asparaginase | Intervention Type: DRUG; Name: asparaginase; Assigned to Arm(s): asparaginase medac | Intervention Type: DRUG; Name: recombinant asparaginase; Assigned to Arm(s): recombinant asparaginase

Answer: B