Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomized Single Center Comparative Study of the Treatment of Insufficient Greater Saphenous Vein: Surgery vs Ultrasound Guided Sclerotherapy With Foam and Endovenous Laser Therapy
Brief Summary: For more than 100 years, surgery has been the standard of care of varicose veins of the legs. The down side of surgery is that it requires anesthesia, leaves scars, and has a relatively high recurrence rate in the long term (up to 40%). In the last decade, several new techniques have become available but they have not yet been compared to surgery. This trail will evaluate the effectiveness, patients' perspective and cost effectiveness of surgery and non-invasive techniques such as ultrasound guided sclerotherapy with foam and endovenous laser therapy.


Options:
A: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Drug: Varisolve (Polidocanol Endovenous Microfoam) | Arm Label: 2; Type: PLACEBO_COMPARATOR; Interventions: Drug: Agitated Saline | Intervention Type: DRUG; Name: Varisolve (Polidocanol Endovenous Microfoam); Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Agitated Saline; Assigned to Arm(s): 2
B: Arm Label: EndoVenous Laser Ablation; Type: ACTIVE_COMPARATOR; Interventions: Device: EVLA, Drug: Lidocaine with 1:200,000 epinephrine solution, Drug: Sodium Bicarbonate | Arm Label: MechanoChemical Ablation (ClariVein®); Type: ACTIVE_COMPARATOR; Interventions: Device: ClariVein®, Drug: Lidocaine with 1:200,000 epinephrine solution, Drug: Sodium Tetradecyl Sulphate | Intervention Type: DEVICE; Name: EVLA; Assigned to Arm(s): EndoVenous Laser Ablation | Intervention Type: DEVICE; Name: ClariVein®; Assigned to Arm(s): MechanoChemical Ablation (ClariVein®) | Intervention Type: DRUG; Name: Lidocaine with 1:200,000 epinephrine solution; Assigned to Arm(s): EndoVenous Laser Ablation, MechanoChemical Ablation (ClariVein®) | Intervention Type: DRUG; Name: Lidocaine with 1:200,000 epinephrine solution; Assigned to Arm(s): EndoVenous Laser Ablation | Intervention Type: DRUG; Name: Sodium Bicarbonate; Assigned to Arm(s): EndoVenous Laser Ablation | Intervention Type: DRUG; Name: Sodium Tetradecyl Sulphate; Assigned to Arm(s): MechanoChemical Ablation (ClariVein®)
C: Arm Label: Polidocanol injectable foam 0.125%; Type: EXPERIMENTAL; Interventions: Drug: Polidocanol injectable foam (PEM) | Arm Label: Polidocanol injectable foam 0.5%; Type: EXPERIMENTAL; Interventions: Drug: Polidocanol injectable foam (PEM) | Arm Label: Polidocanol injectable foam 1.0%; Type: EXPERIMENTAL; Interventions: Drug: Polidocanol injectable foam (PEM) | Arm Label: Polidocanol injectable foam 2.0%; Type: EXPERIMENTAL; Interventions: Drug: Polidocanol injectable foam (PEM) | Arm Label: Vehicle; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo Vehicle | Intervention Type: DRUG; Name: Polidocanol injectable foam (PEM); Assigned to Arm(s): Polidocanol injectable foam 0.125%, Polidocanol injectable foam 0.5%, Polidocanol injectable foam 1.0%, Polidocanol injectable foam 2.0% | Intervention Type: DRUG; Name: Placebo Vehicle; Assigned to Arm(s): Vehicle
D: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Procedure: crossectomy and short stripping | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Procedure: ultrasound guided sclerotherapy with foam | Arm Label: 3; Type: ACTIVE_COMPARATOR; Interventions: Procedure: endovenous laser therapy | Intervention Type: PROCEDURE; Name: crossectomy and short stripping; Assigned to Arm(s): 1 | Intervention Type: PROCEDURE; Name: ultrasound guided sclerotherapy with foam; Assigned to Arm(s): 2 | Intervention Type: PROCEDURE; Name: endovenous laser therapy; Assigned to Arm(s): 3

Answer: D