Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Combination With Intravenous Iron Supplementation or Doubling Erythropoietin Dose for Patients With Chemotherapy-induced Anaemia Inadequately Responsive to Initial Erythropoietin Treatment Alone
Brief Summary: A multicentre, randomized, open-label, parallel-group, active controlled non-inferiority study


Options:
A: Arm Label: Arm A (ibrutinib, rituximab); Type: EXPERIMENTAL; Interventions: Drug: Ibrutinib, Other: Laboratory Biomarker Analysis, Other: Pharmacogenomic Study, Other: Quality-of-Life Assessment, Biological: Rituximab | Arm Label: Arm B (rituximab, fludarabine phosphate, cyclophosphamide); Type: ACTIVE_COMPARATOR; Interventions: Drug: Cyclophosphamide, Drug: Fludarabine Phosphate, Other: Laboratory Biomarker Analysis, Other: Pharmacogenomic Study, Other: Quality-of-Life Assessment, Biological: Rituximab | Intervention Type: DRUG; Name: Cyclophosphamide; Assigned to Arm(s): Arm B (rituximab, fludarabine phosphate, cyclophosphamide) | Intervention Type: DRUG; Name: Fludarabine Phosphate; Assigned to Arm(s): Arm B (rituximab, fludarabine phosphate, cyclophosphamide) | Intervention Type: DRUG; Name: Ibrutinib; Assigned to Arm(s): Arm A (ibrutinib, rituximab) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Arm A (ibrutinib, rituximab), Arm B (rituximab, fludarabine phosphate, cyclophosphamide) | Intervention Type: OTHER; Name: Pharmacogenomic Study; Assigned to Arm(s): Arm A (ibrutinib, rituximab), Arm B (rituximab, fludarabine phosphate, cyclophosphamide) | Intervention Type: OTHER; Name: Quality-of-Life Assessment; Assigned to Arm(s): Arm A (ibrutinib, rituximab), Arm B (rituximab, fludarabine phosphate, cyclophosphamide) | Intervention Type: BIOLOGICAL; Name: Rituximab; Assigned to Arm(s): Arm A (ibrutinib, rituximab), Arm B (rituximab, fludarabine phosphate, cyclophosphamide)
B: Arm Label: iron isomaltoside 1000; Type: EXPERIMENTAL; Interventions: Drug: iron isomaltoside 1000 | Arm Label: iron sulphate; Type: ACTIVE_COMPARATOR; Interventions: Drug: iron sulphate | Intervention Type: DRUG; Name: iron isomaltoside 1000; Assigned to Arm(s): iron isomaltoside 1000 | Intervention Type: DRUG; Name: iron sulphate; Assigned to Arm(s): iron sulphate
C: Arm Label: Arm A (lenalidomide); Type: ACTIVE_COMPARATOR; Interventions: Procedure: Bone Marrow Biopsy, Other: Laboratory Biomarker Analysis, Drug: Lenalidomide | Arm Label: Arm B (lenalidomide, epoetin alfa); Type: EXPERIMENTAL; Interventions: Procedure: Bone Marrow Biopsy, Biological: Epoetin Alfa, Other: Laboratory Biomarker Analysis, Drug: Lenalidomide | Intervention Type: PROCEDURE; Name: Bone Marrow Biopsy; Assigned to Arm(s): Arm A (lenalidomide), Arm B (lenalidomide, epoetin alfa) | Intervention Type: BIOLOGICAL; Name: Epoetin Alfa; Assigned to Arm(s): Arm B (lenalidomide, epoetin alfa) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Arm A (lenalidomide), Arm B (lenalidomide, epoetin alfa) | Intervention Type: DRUG; Name: Lenalidomide; Assigned to Arm(s): Arm A (lenalidomide), Arm B (lenalidomide, epoetin alfa)
D: Arm Label: EPO plus sustained iron dextran; Type: EXPERIMENTAL; Interventions: Drug: Erythropoietins (EPO), Drug: Sustained iron dextran supplementation | Arm Label: EPO plus aggressive iron dextran; Type: EXPERIMENTAL; Interventions: Drug: Erythropoietins (EPO), Drug: Aggressive iron dextran supplementation | Arm Label: Double EPO; Type: ACTIVE_COMPARATOR; Interventions: Drug: Erythropoietins (EPO) | Intervention Type: DRUG; Name: Erythropoietins (EPO); Assigned to Arm(s): EPO plus aggressive iron dextran, EPO plus sustained iron dextran | Intervention Type: DRUG; Name: Aggressive iron dextran supplementation; Assigned to Arm(s): EPO plus aggressive iron dextran | Intervention Type: DRUG; Name: Erythropoietins (EPO); Assigned to Arm(s): Double EPO | Intervention Type: DRUG; Name: Sustained iron dextran supplementation; Assigned to Arm(s): EPO plus sustained iron dextran

Answer: D