Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomised, Double-Blind, Placebo-Controlled, Multi-Centre Phase 3 Study to Determine the Treatment Effect of Denosumab in Subjects With Non-Metastatic Breast Cancer Receiving Aromatase Inhibitor Therapy.
Brief Summary: The purpose of this study is to determine whether denosumab compared to placebo, will reduce the rate of first clinical fracture in women with non-metastatic breast cancer receiving (non-steroidal) aromatase inhibitor therapy.


Options:
A: Arm Label: Zometa; Type: EXPERIMENTAL; Interventions: Drug: Zometa, Drug: Epirubicin, Drug: Docetaxel, Drug: Trastuzumab, Radiation: External beam radiation, Procedure: Modified radical mastectomy or breast conserving surgery with axillary lymph node dissection | Arm Label: No Zometa; Type: ACTIVE_COMPARATOR; Interventions: Drug: Epirubicin, Drug: Docetaxel, Drug: Trastuzumab, Radiation: External beam radiation, Procedure: Modified radical mastectomy or breast conserving surgery with axillary lymph node dissection | Intervention Type: DRUG; Name: Zometa; Assigned to Arm(s): Zometa | Intervention Type: DRUG; Name: Epirubicin; Assigned to Arm(s): No Zometa, Zometa | Intervention Type: DRUG; Name: Docetaxel; Assigned to Arm(s): No Zometa, Zometa | Intervention Type: DRUG; Name: Trastuzumab; Assigned to Arm(s): No Zometa, Zometa | Intervention Type: RADIATION; Name: External beam radiation; Assigned to Arm(s): No Zometa, Zometa | Intervention Type: PROCEDURE; Name: Modified radical mastectomy or breast conserving surgery with axillary lymph node dissection; Assigned to Arm(s): No Zometa, Zometa
B: Arm Label: Pamidronate and placebo; Type: ACTIVE_COMPARATOR; Interventions: Drug: Pamidronate, Drug: placebo | Arm Label: Zoledronic acid and placebo; Type: ACTIVE_COMPARATOR; Interventions: Drug: Zoledronic acid, Drug: placebo | Intervention Type: DRUG; Name: Pamidronate; Assigned to Arm(s): Pamidronate and placebo | Intervention Type: DRUG; Name: Zoledronic acid; Assigned to Arm(s): Zoledronic acid and placebo | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Pamidronate and placebo, Zoledronic acid and placebo
C: Arm Label: AZ (Arimidex+Zoledronate); Type: ACTIVE_COMPARATOR; Interventions: Drug: anastrozole, Drug: zoledronic acid, Other: goserelin | Arm Label: TZ (Tamoxifen+Zoledronate); Type: ACTIVE_COMPARATOR; Interventions: Drug: tamoxifen, Drug: zoledronic acid, Other: goserelin | Arm Label: AC (Arimidex Control); Type: ACTIVE_COMPARATOR; Interventions: Drug: anastrozole, Other: goserelin | Arm Label: TC (Tamoxifen Control); Type: ACTIVE_COMPARATOR; Interventions: Drug: tamoxifen, Other: goserelin | Intervention Type: DRUG; Name: tamoxifen; Assigned to Arm(s): TC (Tamoxifen Control), TZ (Tamoxifen+Zoledronate) | Intervention Type: DRUG; Name: anastrozole; Assigned to Arm(s): AC (Arimidex Control), AZ (Arimidex+Zoledronate) | Intervention Type: DRUG; Name: zoledronic acid; Assigned to Arm(s): AZ (Arimidex+Zoledronate), TZ (Tamoxifen+Zoledronate) | Intervention Type: OTHER; Name: goserelin; Assigned to Arm(s): AC (Arimidex Control), AZ (Arimidex+Zoledronate), TC (Tamoxifen Control), TZ (Tamoxifen+Zoledronate)
D: Arm Label: Denosumab; Type: EXPERIMENTAL; Interventions: Biological: Denosumab, Drug: Non-steroidal aromatase inhibitor therapy | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Drug: Non-steroidal aromatase inhibitor therapy | Arm Label: SubStudy: Zoledronic Acid; Type: EXPERIMENTAL; Interventions: Drug: Zoledronic Acid | Arm Label: Substudy: Standard of Care; Type: OTHER; Interventions: Other: Standard of Care | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo | Intervention Type: BIOLOGICAL; Name: Denosumab; Assigned to Arm(s): Denosumab | Intervention Type: DRUG; Name: Non-steroidal aromatase inhibitor therapy; Assigned to Arm(s): Denosumab, Placebo | Intervention Type: DRUG; Name: Zoledronic Acid; Assigned to Arm(s): SubStudy: Zoledronic Acid | Intervention Type: OTHER; Name: Standard of Care; Assigned to Arm(s): Substudy: Standard of Care

Answer: D