Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Early Salvage With High Dose Chemotherapy and Stem Cell Transplantation in Advanced Stage Hodgkin's Lymphoma Patients With Positive PET After Two Courses of ABVD (PET-2 Positive) and Comparison of RT Versus no RT in PET-2 Negative Patients
Brief Summary: The purpose of this study is to define an improvement in patients:

* To evaluate if patients resistant to the initial treatment for residual PET-positive masses after the first two courses of ABVD (PET-2 positive), can be salvaged by early shift to high-dose chemotherapy supported by stem cell rescue
* To analyse if patients achieving early complete response (PET-2 negative), can be spared the adjuvant radiotherapy on areas of initial bulky disease, at the end of the planned six courses of ABVD. To answer this question, PET-2 negative patients will be randomized between radiotherapy versus no radiotherapy at the end of ABVD therapy.


Options:
A: Arm Label: PET pos; Type: EXPERIMENTAL; Interventions: Drug: ESCALATED BEACOPP | Arm Label: PET negative; Type: OTHER; Interventions: Drug: CONVENTIONAL ABVD | Intervention Type: DRUG; Name: ESCALATED BEACOPP; Assigned to Arm(s): PET pos | Intervention Type: DRUG; Name: CONVENTIONAL ABVD; Assigned to Arm(s): PET negative
B: Arm Label: Arm A; Type: OTHER; Interventions: Drug: ABVD | Arm Label: Arm B; Type: OTHER; Interventions: Drug: ABVD and Radiotherapy | Intervention Type: DRUG; Name: ABVD; Assigned to Arm(s): Arm A | Intervention Type: DRUG; Name: ABVD and Radiotherapy; Assigned to Arm(s): Arm B
C: Arm Label: Arm I; Type: ACTIVE_COMPARATOR; Interventions: Biological: bleomycin sulfate, Drug: dacarbazine, Drug: doxorubicin hydrochloride, Drug: vinblastine sulfate | Arm Label: Arm II; Type: ACTIVE_COMPARATOR; Interventions: Drug: dacarbazine, Drug: doxorubicin hydrochloride, Drug: vinblastine sulfate | Arm Label: BEACOPP-14 chemotherapy; Type: EXPERIMENTAL; Interventions: Biological: bleomycin sulfate, Biological: filgrastim, Biological: pegfilgrastim, Drug: cyclophosphamide, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: prednisolone, Drug: procarbazine hydrochloride, Drug: vincristine sulfate | Arm Label: BEACOPP-escalated chemotherapy; Type: EXPERIMENTAL; Interventions: Biological: bleomycin sulfate, Biological: filgrastim, Biological: pegfilgrastim, Drug: cyclophosphamide, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: prednisolone, Drug: procarbazine hydrochloride, Drug: vincristine sulfate | Intervention Type: BIOLOGICAL; Name: bleomycin sulfate; Assigned to Arm(s): Arm I, BEACOPP-14 chemotherapy, BEACOPP-escalated chemotherapy | Intervention Type: BIOLOGICAL; Name: filgrastim; Assigned to Arm(s): BEACOPP-14 chemotherapy, BEACOPP-escalated chemotherapy | Intervention Type: BIOLOGICAL; Name: pegfilgrastim; Assigned to Arm(s): BEACOPP-14 chemotherapy, BEACOPP-escalated chemotherapy | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): BEACOPP-14 chemotherapy, BEACOPP-escalated chemotherapy | Intervention Type: DRUG; Name: dacarbazine; Assigned to Arm(s): Arm I, Arm II | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): Arm I, Arm II, BEACOPP-14 chemotherapy, BEACOPP-escalated chemotherapy | Intervention Type: DRUG; Name: etoposide; Assigned to Arm(s): BEACOPP-14 chemotherapy, BEACOPP-escalated chemotherapy | Intervention Type: DRUG; Name: prednisolone; Assigned to Arm(s): BEACOPP-14 chemotherapy, BEACOPP-escalated chemotherapy | Intervention Type: DRUG; Name: procarbazine hydrochloride; Assigned to Arm(s): BEACOPP-14 chemotherapy, BEACOPP-escalated chemotherapy | Intervention Type: DRUG; Name: vinblastine sulfate; Assigned to Arm(s): Arm I, Arm II | Intervention Type: DRUG; Name: vincristine sulfate; Assigned to Arm(s): BEACOPP-14 chemotherapy, BEACOPP-escalated chemotherapy
D: Arm Label: doxorubicin + vinblastine + gemcitabine; Type: EXPERIMENTAL; Interventions: Drug: doxorubicin hydrochloride, Drug: gemcitabine hydrochloride, Drug: vinblastine, Procedure: fludeoxyglucose F 18 positron-emission tomography (PET) scan, Procedure: CT scan | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): doxorubicin + vinblastine + gemcitabine | Intervention Type: DRUG; Name: gemcitabine hydrochloride; Assigned to Arm(s): doxorubicin + vinblastine + gemcitabine | Intervention Type: DRUG; Name: vinblastine; Assigned to Arm(s): doxorubicin + vinblastine + gemcitabine | Intervention Type: PROCEDURE; Name: fludeoxyglucose F 18 positron-emission tomography (PET) scan; Assigned to Arm(s): doxorubicin + vinblastine + gemcitabine | Intervention Type: PROCEDURE; Name: CT scan; Assigned to Arm(s): doxorubicin + vinblastine + gemcitabine

Answer: B