Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase 2B, Multi-Center, Randomized, Double-Blinded, Parallel-Arm , Study to Assess Efficacy and Safety of 3'-Aminomethylnicotine-P. Aeruginosa r-Exoprotein A Conjugate Vaccine (NicVAX®) or Placebo Co-Administered With Varenicline (Champix®) as an Aid in Smoking Cessation
Brief Summary: The purpose of this study is to evaluate the efficacy and safety of NicVAX co-administered with varenicline as an aid in smoking cessation over a one-year period in smokers who want to quit smoking.


Options:
A: Arm Label: Varenicline Tartrate; Type: ACTIVE_COMPARATOR; Interventions: Drug: Varenicline Tartrate | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Varenicline Tartrate; Assigned to Arm(s): Varenicline Tartrate | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
B: Arm Label: Tailored intervention; Type: EXPERIMENTAL; Interventions: Drug: Nicotine replacement therapy - Transdermal nicotine patch, Drug: Nicotine replacement therapy - Nicotine gum, Drug: Nicotine replacement therapy - Nicotine lozenge, Drug: Bupropion, Drug: Varenicline, Drug: Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum, Drug: Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge, Drug: Combination pharmacotherapy - Transdermal nicotine patch + bupropion, Behavioral: Tailored behavioral intervention, Behavioral: Alcohol use risk reduction, Behavioral: Behavioral activation for depressive symptoms, Behavioral: Behavioral management of postcessation weight gain | Arm Label: Enhanced standard of care; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine replacement therapy - Transdermal nicotine patch, Drug: Nicotine replacement therapy - Nicotine gum, Drug: Nicotine replacement therapy - Nicotine lozenge, Drug: Bupropion, Drug: Varenicline, Drug: Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum, Drug: Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge, Drug: Combination pharmacotherapy - Transdermal nicotine patch + bupropion, Behavioral: Tobacco quitline referral | Intervention Type: DRUG; Name: Nicotine replacement therapy - Transdermal nicotine patch; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: DRUG; Name: Nicotine replacement therapy - Nicotine gum; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: DRUG; Name: Nicotine replacement therapy - Nicotine lozenge; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: DRUG; Name: Bupropion; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: DRUG; Name: Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: DRUG; Name: Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: DRUG; Name: Combination pharmacotherapy - Transdermal nicotine patch + bupropion; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: BEHAVIORAL; Name: Tobacco quitline referral; Assigned to Arm(s): Enhanced standard of care | Intervention Type: BEHAVIORAL; Name: Tailored behavioral intervention; Assigned to Arm(s): Tailored intervention | Intervention Type: BEHAVIORAL; Name: Alcohol use risk reduction; Assigned to Arm(s): Tailored intervention | Intervention Type: BEHAVIORAL; Name: Behavioral activation for depressive symptoms; Assigned to Arm(s): Tailored intervention | Intervention Type: BEHAVIORAL; Name: Behavioral management of postcessation weight gain; Assigned to Arm(s): Tailored intervention
C: Intervention Type: DRUG; Name: CP-526,555 (varenicline); Assigned to Arm(s): N/A
D: Arm Label: NicVAX conjugate vaccine; Type: EXPERIMENTAL; Interventions: Biological: NicVAX vaccine, Drug: Varenicline | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo, Drug: Varenicline | Intervention Type: BIOLOGICAL; Name: NicVAX vaccine; Assigned to Arm(s): NicVAX conjugate vaccine | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): NicVAX conjugate vaccine, Placebo

Answer: D