Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: The Canadian HIV Quit Smoking Trial: Tackling the Co-morbidities of Depression and Cardiovascular Disease in HIV+ Smokers
Brief Summary: The objectives of this trial are:

Primary objectives:

1. To determine among HIV+ individuals whether varenicline or NRT is more effective at helping individuals remain abstinent from smoking tobacco.
2. To determine among HIV+ individuals whether varenicline or NRT has the lowest side-effect profile.
3. To determine if the HIV tailored Quit Smoking Counselling Intervention, plus smoking cessation drug therapy, improves smoking cessation rates compared to smoking cessation drug therapy alone with usual care.

Secondary objective:

1. To determine whether the use of varenicline/NRT is safe in HIV+ patients who exhibit depressive symptoms.

Hypothesis:

That varenicline will result in higher quit smoking rates and that NRT will result in a lower side effect profile. Further, the HIV tailored quit smoking intervention will result in higher rates of smoking cessation over and above the pharmacological treatment alone. And finally, varenicline will be safe to use for HIV + individuals who exhibit depressive symptoms.


Options:
A: Arm Label: High Intensity Counseling + Long Acting NRT + PRN NRT; Type: EXPERIMENTAL; Interventions: Drug: High Intensity Counseling + Long Acting NRT + PRN NRT | Arm Label: High Intensity Counseling + bupropion + PRN NRT; Type: EXPERIMENTAL; Interventions: Drug: High Intensity Counseling + bupropion + PRN NRT | Arm Label: High Intensity Counseling + varenicline + PRN NRT; Type: EXPERIMENTAL; Interventions: Drug: High Intensity Counseling + varenicline + PRN NRT | Arm Label: High Intensity Counseling + Long Acting NRT; Type: EXPERIMENTAL; Interventions: Drug: High Intensity Counseling + Long Acting NRT | Arm Label: High Intensity Counseling + bupropion; Type: EXPERIMENTAL; Interventions: Drug: High Intensity Counseling + bupropion | Arm Label: High Intensity Counseling + varenicline; Type: EXPERIMENTAL; Interventions: Drug: High Intensity Counseling + varenicline | Arm Label: Low Intensity Counseling + Long Acting NRT + PRN NRT; Type: EXPERIMENTAL; Interventions: Drug: Low Intensity Counseling + Long Acting NRT + PRN NRT | Arm Label: Low Intensity Counseling + bupropion + PRN NRT; Type: EXPERIMENTAL; Interventions: Drug: Low Intensity Counseling + bupropion + PRN NRT | Arm Label: Low Intensity Counseling + varenicline + PRN NRT; Type: EXPERIMENTAL; Interventions: Drug: Low Intensity Counseling + varenicline + PRN NRT | Arm Label: Low Intensity Counseling + Long Acting NRT; Type: EXPERIMENTAL; Interventions: Drug: Low Intensity Counseling + Long Acting NRT | Arm Label: Low Intensity Counseling + bupropion; Type: EXPERIMENTAL; Interventions: Drug: Low Intensity Counseling + bupropion | Arm Label: Low Intensity Counseling + varenicline; Type: EXPERIMENTAL; Interventions: Drug: Low Intensity Counseling + varenicline | Intervention Type: DRUG; Name: High Intensity Counseling + Long Acting NRT + PRN NRT; Assigned to Arm(s): High Intensity Counseling + Long Acting NRT + PRN NRT | Intervention Type: DRUG; Name: High Intensity Counseling + bupropion + PRN NRT; Assigned to Arm(s): High Intensity Counseling + bupropion + PRN NRT | Intervention Type: DRUG; Name: High Intensity Counseling + varenicline + PRN NRT; Assigned to Arm(s): High Intensity Counseling + varenicline + PRN NRT | Intervention Type: DRUG; Name: High Intensity Counseling + Long Acting NRT; Assigned to Arm(s): High Intensity Counseling + Long Acting NRT | Intervention Type: DRUG; Name: High Intensity Counseling + bupropion; Assigned to Arm(s): High Intensity Counseling + bupropion | Intervention Type: DRUG; Name: High Intensity Counseling + varenicline; Assigned to Arm(s): High Intensity Counseling + varenicline | Intervention Type: DRUG; Name: Low Intensity Counseling + Long Acting NRT + PRN NRT; Assigned to Arm(s): Low Intensity Counseling + Long Acting NRT + PRN NRT | Intervention Type: DRUG; Name: Low Intensity Counseling + bupropion + PRN NRT; Assigned to Arm(s): Low Intensity Counseling + bupropion + PRN NRT | Intervention Type: DRUG; Name: Low Intensity Counseling + varenicline + PRN NRT; Assigned to Arm(s): Low Intensity Counseling + varenicline + PRN NRT | Intervention Type: DRUG; Name: Low Intensity Counseling + Long Acting NRT; Assigned to Arm(s): Low Intensity Counseling + Long Acting NRT | Intervention Type: DRUG; Name: Low Intensity Counseling + bupropion; Assigned to Arm(s): Low Intensity Counseling + bupropion | Intervention Type: DRUG; Name: Low Intensity Counseling + varenicline; Assigned to Arm(s): Low Intensity Counseling + varenicline
B: Arm Label: Tailored intervention; Type: EXPERIMENTAL; Interventions: Drug: Nicotine replacement therapy - Transdermal nicotine patch, Drug: Nicotine replacement therapy - Nicotine gum, Drug: Nicotine replacement therapy - Nicotine lozenge, Drug: Bupropion, Drug: Varenicline, Drug: Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum, Drug: Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge, Drug: Combination pharmacotherapy - Transdermal nicotine patch + bupropion, Behavioral: Tailored behavioral intervention, Behavioral: Alcohol use risk reduction, Behavioral: Behavioral activation for depressive symptoms, Behavioral: Behavioral management of postcessation weight gain | Arm Label: Enhanced standard of care; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine replacement therapy - Transdermal nicotine patch, Drug: Nicotine replacement therapy - Nicotine gum, Drug: Nicotine replacement therapy - Nicotine lozenge, Drug: Bupropion, Drug: Varenicline, Drug: Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum, Drug: Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge, Drug: Combination pharmacotherapy - Transdermal nicotine patch + bupropion, Behavioral: Tobacco quitline referral | Intervention Type: DRUG; Name: Nicotine replacement therapy - Transdermal nicotine patch; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: DRUG; Name: Nicotine replacement therapy - Nicotine gum; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: DRUG; Name: Nicotine replacement therapy - Nicotine lozenge; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: DRUG; Name: Bupropion; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: DRUG; Name: Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: DRUG; Name: Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: DRUG; Name: Combination pharmacotherapy - Transdermal nicotine patch + bupropion; Assigned to Arm(s): Enhanced standard of care, Tailored intervention | Intervention Type: BEHAVIORAL; Name: Tobacco quitline referral; Assigned to Arm(s): Enhanced standard of care | Intervention Type: BEHAVIORAL; Name: Tailored behavioral intervention; Assigned to Arm(s): Tailored intervention | Intervention Type: BEHAVIORAL; Name: Alcohol use risk reduction; Assigned to Arm(s): Tailored intervention | Intervention Type: BEHAVIORAL; Name: Behavioral activation for depressive symptoms; Assigned to Arm(s): Tailored intervention | Intervention Type: BEHAVIORAL; Name: Behavioral management of postcessation weight gain; Assigned to Arm(s): Tailored intervention
C: Arm Label: Varenicline; Type: EXPERIMENTAL; Interventions: Drug: varenicline | Arm Label: Sugar pill; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Intervention Type: DRUG; Name: varenicline; Assigned to Arm(s): Varenicline | Intervention Type: OTHER; Name: placebo; Assigned to Arm(s): Sugar pill
D: Arm Label: NRT arm; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine Replacement Therapy (NRT) | Arm Label: NRT and HIV Tailored Quit Smoking Counseling; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine Replacement Therapy (NRT), Behavioral: HIV Tailored Quit Smoking Counseling | Arm Label: Varenicline (VR) Arm; Type: ACTIVE_COMPARATOR; Interventions: Drug: Varenicline | Arm Label: Varenicline (VR) and HIV Tailored Quit Smoking Counseling; Type: ACTIVE_COMPARATOR; Interventions: Drug: Varenicline, Behavioral: HIV Tailored Quit Smoking Counseling | Intervention Type: DRUG; Name: Nicotine Replacement Therapy (NRT); Assigned to Arm(s): NRT and HIV Tailored Quit Smoking Counseling, NRT arm | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): Varenicline (VR) Arm, Varenicline (VR) and HIV Tailored Quit Smoking Counseling | Intervention Type: BEHAVIORAL; Name: HIV Tailored Quit Smoking Counseling; Assigned to Arm(s): NRT and HIV Tailored Quit Smoking Counseling, Varenicline (VR) and HIV Tailored Quit Smoking Counseling

Answer: D