Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Phase III Trial Comparing Nicotine Inhaler Versus Bupropion Versus Nicotine Inhaler Plus Bupropion For Smoking Cessation Efficacy And Relapse Prevention
Brief Summary: RATIONALE: Use of a nicotine inhaler and/or bupropion may be effective in helping people stop smoking and prevent them from starting smoking again. It is not yet known whether a nicotine inhaler or bupropion are more effective alone or combined for stopping smoking.

PURPOSE: Randomized phase III trial to compare the effectiveness of the nicotine inhaler or bupropion alone to that of the nicotine inhaler combined with bupropion in helping people to stop smoking and prevent starting smoking again.


Options:
A: Arm Label: Extended Patch Treatment; Type: EXPERIMENTAL; Interventions: Drug: 24-weeks of nicotine patch | Arm Label: Standard Patch Treatment; Type: ACTIVE_COMPARATOR; Interventions: Drug: Standard Patch Treatment | Intervention Type: DRUG; Name: Standard Patch Treatment; Assigned to Arm(s): Standard Patch Treatment | Intervention Type: DRUG; Name: 24-weeks of nicotine patch; Assigned to Arm(s): Extended Patch Treatment
B: Arm Label: Arm I: nicotine inhaler cartridges; Type: EXPERIMENTAL; Interventions: Drug: nicotine | Arm Label: Arm II: bupropion; Type: EXPERIMENTAL; Interventions: Drug: bupropion hydrochloride | Arm Label: Arm III: nicotine inhaler cartridges; Type: EXPERIMENTAL; Interventions: Drug: nicotine | Arm Label: Arm IV: bupropion; Type: EXPERIMENTAL; Interventions: Drug: bupropion hydrochloride | Arm Label: Arm V: placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Arm Label: Arm VI: nicotine inhaler cartridges; Type: EXPERIMENTAL; Interventions: Drug: nicotine | Arm Label: Arm VII: placebo inhaler; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Arm Label: Arm VIII: nicotine inhaler cartridges; Type: EXPERIMENTAL; Interventions: Drug: nicotine | Arm Label: Arm IX: placebo inhaler cartridges; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Arm Label: Arm X: bupropion; Type: EXPERIMENTAL; Interventions: Drug: bupropion hydrochloride | Arm Label: Arm XI: placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Arm Label: Arm XII: nicotine inhaler cartridges; Type: EXPERIMENTAL; Interventions: Drug: nicotine | Arm Label: Arm XIII: placebo inhaler cartridges; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Arm Label: Arm XIV: nicotine inhaler cartridges; Type: EXPERIMENTAL; Interventions: Drug: nicotine | Arm Label: Arm XV: placebo inhaler cartridges; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Intervention Type: OTHER; Name: placebo; Assigned to Arm(s): Arm IX: placebo inhaler cartridges, Arm V: placebo, Arm VII: placebo inhaler, Arm XI: placebo, Arm XIII: placebo inhaler cartridges, Arm XV: placebo inhaler cartridges | Intervention Type: DRUG; Name: bupropion hydrochloride; Assigned to Arm(s): Arm II: bupropion, Arm IV: bupropion, Arm X: bupropion | Intervention Type: DRUG; Name: nicotine; Assigned to Arm(s): Arm I: nicotine inhaler cartridges, Arm III: nicotine inhaler cartridges, Arm VI: nicotine inhaler cartridges, Arm VIII: nicotine inhaler cartridges, Arm XII: nicotine inhaler cartridges, Arm XIV: nicotine inhaler cartridges
C: Arm Label: Varenicline Tartrate; Type: ACTIVE_COMPARATOR; Interventions: Drug: Varenicline Tartrate | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Varenicline Tartrate; Assigned to Arm(s): Varenicline Tartrate | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
D: Arm Label: Nicotine Replacement Therapy Responder; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine Patches | Arm Label: Pre-Quit Rescue to Bupropion & Nicotine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine patches, then bupropion & nicotine patches (Pre-Quit) | Arm Label: Pre-Quit Rescue to Varenicline; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine patches, then varenicline (Pre-Quit) | Arm Label: Pre-Quit Rescue to Nicotine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine patches, then nicotine patches (Pre-Quit) | Arm Label: Post-Quit Rescue to Bupropion & Nicotine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine patches, then bupropion & nicotine patches (Post-Quit) | Arm Label: Post-Quit Rescue to Varenicline; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine patches, then varenicline (Post-Quit) | Arm Label: Post-Quit Rescue to Nicotine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine patches, then nicotine patches (Post-Quit) | Intervention Type: DRUG; Name: Nicotine Patches; Assigned to Arm(s): Nicotine Replacement Therapy Responder | Intervention Type: DRUG; Name: Nicotine patches, then bupropion & nicotine patches (Pre-Quit); Assigned to Arm(s): Pre-Quit Rescue to Bupropion & Nicotine | Intervention Type: DRUG; Name: Nicotine patches, then varenicline (Pre-Quit); Assigned to Arm(s): Pre-Quit Rescue to Varenicline | Intervention Type: DRUG; Name: Nicotine patches, then nicotine patches (Pre-Quit); Assigned to Arm(s): Pre-Quit Rescue to Nicotine | Intervention Type: DRUG; Name: Nicotine patches, then bupropion & nicotine patches (Post-Quit); Assigned to Arm(s): Post-Quit Rescue to Bupropion & Nicotine | Intervention Type: DRUG; Name: Nicotine patches, then varenicline (Post-Quit); Assigned to Arm(s): Post-Quit Rescue to Varenicline | Intervention Type: DRUG; Name: Nicotine patches, then nicotine patches (Post-Quit); Assigned to Arm(s): Post-Quit Rescue to Nicotine

Answer: B