Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomized, Observer Blinded, Controlled Trial to Evaluate the Safety and Immunogenicity of a New Formulation of Euvichol® (Killed Bivalent Whole Cell Oral Cholera Vaccine Manufactured by EuBiologics Co. Ltd.) in Healthy Individuals
Brief Summary: * Number of doses and intervals: Two doses, 2 weeks apart
* Method of administration: Oral administration
* Volume of vaccine to be administered: 1.5 mL/dose
* Observational period: 4 weeks (2 weeks after each dose)
* Number of visits: 3 visits

  1. Visit 1: Screening and enrollment (1st dosing)
  2. Visit 2: 2nd dosing 2 weeks after 1st dose (14+3 days)
  3. Visit 3: 2 weeks after the 2nd dose (28+3 days), end of subject participation. This study will be carried out in healthy adults and children, at two sites, enrollment will be competitive between the sites. Subjects will be stratified according to age into adults (18\~40 years of age) and children (1\~17 years of age). According to the pre-generated randomization list, the participants will be randomized to the test or comparator groups (Visit 1) and will be given either the test vaccine or the comparator vaccine. For immunogenicity assessment, blood sample will be taken at Visit 1 (prior to vaccination), Visit 2 (prior to vaccination), and at the end-of-study Visit (Visit 3). For Safety assessment: the participants will be observed for 30 minutes post vaccination and instructed to record solicited adverse events that occur up to 6 days after vaccination on the participant diary card.

This study is observer-blind: vaccine administrator and vaccine safety evaluator will be two distinct persons to avoid bias of safety assessment. Trial staff other than the vaccine administrator will remain blinded and will not handle the investigational product.


Options:
A: Arm Label: cholvax; Type: EXPERIMENTAL; Interventions: Biological: Cholvax | Arm Label: shanchol; Type: ACTIVE_COMPARATOR; Interventions: Biological: Shanchol | Intervention Type: BIOLOGICAL; Name: Cholvax; Assigned to Arm(s): cholvax | Intervention Type: BIOLOGICAL; Name: Shanchol; Assigned to Arm(s): shanchol
B: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Biological: rBS-WC vaccine | Intervention Type: BIOLOGICAL; Name: rBS-WC vaccine; Assigned to Arm(s): 1
C: Arm Label: Vaccine arm; Type: ACTIVE_COMPARATOR; Interventions: Biological: ShanChol | Arm Label: Vaccine plus hygiene and safe water arm; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Vaccine and behaviour | Arm Label: Non-intervention arm; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BIOLOGICAL; Name: ShanChol; Assigned to Arm(s): Vaccine arm | Intervention Type: BEHAVIORAL; Name: Vaccine and behaviour; Assigned to Arm(s): Vaccine plus hygiene and safe water arm
D: Arm Label: study group; Type: EXPERIMENTAL; Interventions: Biological: Test Oral Cholera Vaccine | Arm Label: comparator group; Type: ACTIVE_COMPARATOR; Interventions: Biological: Euvichol® | Intervention Type: BIOLOGICAL; Name: Test Oral Cholera Vaccine; Assigned to Arm(s): study group | Intervention Type: BIOLOGICAL; Name: Euvichol®; Assigned to Arm(s): comparator group

Answer: D