Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomized Phase 3b Study of Three Treatment Regimens in Subjects With Previously Untreated Multiple Myeloma Who Are Not Considered Candidates for High-Dose Chemotherapy and Autologous Stem Cell Transplantation: VELCADE, Thalidomide, and Dexamethasone Versus VELCADE and Dexamethasone Versus VELCADE, Melphalan, and Prednisone
Brief Summary: This is a randomized, open label, multicenter clinical trial to compare the efficacy and safety of Velcade (bortezomib) and dexamethasone versus Velcade, thalidomide, and dexamethasone versus Velcade, melphalan, and prednisone in patients with previously untreated multiple myeloma not considered candidates for high-dose chemotherapy and autologous stem cell transplantation.


Options:
A: Arm Label: Bortezomib and Dexamethasone (VD); Type: EXPERIMENTAL; Interventions: Drug: Bortezomib, Drug: Dexamethasone | Arm Label: Bortezomib, Thalidomide, and Dexamethasone (VTD); Type: EXPERIMENTAL; Interventions: Drug: Bortezomib, Drug: Dexamethasone, Drug: Thalidomide | Arm Label: Bortezomib, Melphalan and Prednisone (VMP); Type: EXPERIMENTAL; Interventions: Drug: Bortezomib, Drug: Melphalan, Drug: Prednisone | Intervention Type: DRUG; Name: Bortezomib; Assigned to Arm(s): Bortezomib and Dexamethasone (VD), Bortezomib, Melphalan and Prednisone (VMP), Bortezomib, Thalidomide, and Dexamethasone (VTD) | Intervention Type: DRUG; Name: Dexamethasone; Assigned to Arm(s): Bortezomib and Dexamethasone (VD), Bortezomib, Thalidomide, and Dexamethasone (VTD) | Intervention Type: DRUG; Name: Melphalan; Assigned to Arm(s): Bortezomib, Melphalan and Prednisone (VMP) | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): Bortezomib, Melphalan and Prednisone (VMP) | Intervention Type: DRUG; Name: Thalidomide; Assigned to Arm(s): Bortezomib, Thalidomide, and Dexamethasone (VTD)
B: Arm Label: A; Type: PLACEBO_COMPARATOR; Interventions: Drug: thalidomide, Drug: placebo | Arm Label: B; Type: ACTIVE_COMPARATOR; Interventions: Drug: thalidomide, Drug: placebo | Intervention Type: DRUG; Name: thalidomide; Assigned to Arm(s): A, B | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): A, B
C: Arm Label: MPR+R; Type: EXPERIMENTAL; Interventions: Drug: Lenalidomide: Double-blind Induction, Drug: Melphalan, Drug: Prednisone, Drug: Aspirin, Drug: Lenalidomide: Double-blind Maintenance, Drug: Lenalidomide: Open-label | Arm Label: MPR+p; Type: EXPERIMENTAL; Interventions: Drug: Lenalidomide: Double-blind Induction, Drug: Melphalan, Drug: Prednisone, Drug: Aspirin, Drug: Placebo, Drug: Lenalidomide: Open-label | Arm Label: MPp+p; Type: OTHER; Interventions: Drug: Melphalan, Drug: Prednisone, Drug: Aspirin, Drug: Placebo, Drug: Lenalidomide: Open-label | Intervention Type: DRUG; Name: Lenalidomide: Double-blind Induction; Assigned to Arm(s): MPR+R, MPR+p | Intervention Type: DRUG; Name: Melphalan; Assigned to Arm(s): MPR+R, MPR+p, MPp+p | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): MPR+R, MPR+p, MPp+p | Intervention Type: DRUG; Name: Aspirin; Assigned to Arm(s): MPR+R, MPR+p, MPp+p | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): MPR+p, MPp+p | Intervention Type: DRUG; Name: Lenalidomide: Double-blind Maintenance; Assigned to Arm(s): MPR+R | Intervention Type: DRUG; Name: Lenalidomide: Open-label; Assigned to Arm(s): MPR+R, MPR+p, MPp+p
D: Arm Label: Rd; Type: ACTIVE_COMPARATOR; Interventions: Drug: Lenalidomide, dexamethasone | Arm Label: MPR; Type: EXPERIMENTAL; Interventions: Drug: Melphalan, Prednisone, Lenalidomide | Arm Label: CPR; Type: EXPERIMENTAL; Interventions: Drug: Cyclophosphamide, Prednisone, Lenalidomide | Intervention Type: DRUG; Name: Melphalan, Prednisone, Lenalidomide; Assigned to Arm(s): MPR | Intervention Type: DRUG; Name: Cyclophosphamide, Prednisone, Lenalidomide; Assigned to Arm(s): CPR | Intervention Type: DRUG; Name: Lenalidomide, dexamethasone; Assigned to Arm(s): Rd

Answer: A