Please select the eligibility criteria that correspond to the clinical trial below.
Title: Web-Based Weight Loss & Weight Maintenance Intervention for Older Rural Women
Brief Summary: This project will evaluate an Internet delivery strategy to address weight loss and maintenance among rural midlife and older women.


Options:
A: Inclusion Criteria:

* Age ≥ 18 and ≤ 65 years of age
* HIV positive, on a stable combination antiretroviral regimen for \> 6 months, including but not limited to either 2 nucleoside reverse transcriptase inhibitors (NRTI) and a non-nucleoside reverse transcriptase inhibitors (NNRTI) or protease inhibitor (PI), or a triple NRTI regimen
* Ability and motivation to modify behavior and make lifestyle changes
* NCEP-Adult Treatment Panel III defined metabolic syndrome, as defined by 3 out of 5 of the following: 1) Waist circumference greater than 102 cm (40 in) in men and 88 cm (35 in) in women, 2) Triglycerides ≥ 150 mg/dL or current anti-lipolytic drug treatment, 3) high-density lipoprotein less than 40mg/dL in men and 50 mg/dL in women, 4) Blood pressure ≥ 130/85 mmHg or current antihypertensive drug treatment, 5) Fasting glucose ≥ 100 mg/dL

Exclusion Criteria:

* Any new serious opportunistic infection within the past 6 weeks
* History of unstable angina, aortic stenosis, uncontrolled hypertension, severe neuropathy, arthritis or other contraindication to exercise
* Current therapy with insulin or other diabetic agent, fasting blood sugar \> 126
* Requiring parenteral nutrition or parenteral glucocorticoid therapy or oral glucocorticoid therapy
* Estrogen, progestational derivative, or ketoconazole use within 3 months
* New antiretroviral regimen in the past 6 months
* Serum creatinine \> 1.5 mg/dL (males) and 1.4 mg/dL (females), serum glutamic pyruvic transaminase-liver function (SGPT), \> 2.5 upper limit of normal (ULN), Lactate \> 2.0 ULN, hemoglobin \< 10.0 mg/dL
* Current substance and/or alcohol abuse
* Known hypersensitivity to Metformin
* Congestive heart failure requiring pharmacologic treatment
* Use of cimetidine or planned use during the study period
* Hypertrophic obstructive cardiomyopathy
* Pregnant or actively seeking pregnancy, breastfeeding
* Testosterone use for non-physiologic purposes, or physiologic testosterone replacement for \< 3 months.
* Presence of active AIDS including cancers
* Current viral, bacterial or other infections (excluding HIV)
* Weight loss in the past 3 months of greater than 10 pounds
* Nitrates or other medications that can alter endothelial function
* Contraindication to beta blocker or nitroglycerin use
* Patients with previous allergic reactions to iodine-containing contrast media or to iodine
B: Inclusion Criteria:

* female (25-50 years old)
* pre-menopausal
* BMI between 25 and 40 kg/m2
* willing to attend weekly meetings (during 1 year)
* willing to not participate in other formal or informal weight loss program during the first year of the study (intervention group only).

Exclusion Criteria:

* major/chronic illness
* taking (or having taken in the previous year) medication known to interfere with body weight regulation, including anti-depressive medication
C: Inclusion Criteria:

* women aged 40-69
* overweight or Class I \& II obese (BMI 28 to 39.9)or BMI 40 to 45 with physician clearance
* state a commitment to losing weight
* speak and read English
* able to communicate over the telephone
* able to use a computer with minimal assistance and complete electronic forms and surveys
* have access to and are able to access the Internet
* commitment to access the website as required by the research intervention including weekly self-reporting of calories and fat grams, weekly self-reporting of physical activity, pedometer steps, and body weight, and weekly (or more often) participation in other website components as determined by group to which randomized and phase of intervention
* have or are willing to obtain an email account
* have access to a DVD player
* able to walk without an assistive device
* answer 'no' to all questions on the Physical Activity Readiness Questionnaire (PAR-Q) or obtain clearance from their physician to become more active

Exclusion Criteria:

* diagnosed with Type 1 diabetes
* diagnosed with Type 2 diabetes and require insulin
* ≥ 10% weight loss in last six months
* enrolled in a weight loss management program
* enrolled in a formal program of cardiac rehabilitation or undergoing physical rehabilitation
* taking medications that affect weight loss or weight gain
* other physical or medical restrictions that would preclude following the minimum recommendations for moderate physical activity and healthy eating.
D: Inclusion Criteria:

* mother of infant aged 2-12 months
* sedentary
* healthy, able to do moderate intensity physical activity
* BMI = 18.5-40
* not planning to become pregnant in next year
* woman aged 18-45
* able speak and read English

Exclusion Criteria:

* pregnant
* planning to leave Oahu, Hawaii in the next year (permanently move away)
* a diagnosis of cancer, coronary heart disease (including atrial fibrillation), insulin-dependent diabetes mellitus (IDDM), and other atherosclerotic cardiovascular diseases (e.g., stroke),

Answer: C