Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: The Effect of Quetiapine on Psychotic-Like Symptoms in Borderline Personality Disordered Patients: A Randomised Placebo-Controlled Trial
Brief Summary: In patients with schizophrenia, 'atypical' antipsychotics such as clozapine may be effective in the treatment of psychosis. In patients with borderline personality disorder (BPD), as far as the investigators know, no well designed controlled studies have been performed on the effect of one of the newer atypical antipsychotics on psychotic symptoms.

It is of interest to investigate the benefit of quetiapine treatment in these types of patients. Quetiapine possibly gives less side-effects because of the expected lack of elevated prolactin levels, which is of importance in this patient group, overrepresented by young females. In this double blind, randomized, placebo controlled, 8 week, parallel group, multi-center study, quetiapine (in flexible doses between 200 mg/day and 600 mg/day) will be compared with the placebo.


Options:
A: Arm Label: Ketamine; Type: EXPERIMENTAL; Interventions: Other: Baseline evaluation, Drug: 1st perfusion of ketamine, Other: Follow-up between perfusions, Drug: 2nd perfusion of ketamine | Arm Label: Placebo/Control; Type: PLACEBO_COMPARATOR; Interventions: Other: Baseline evaluation, Drug: 1st perfusion of saline, Other: Follow-up between perfusions, Drug: 2nd perfusion of saline | Intervention Type: OTHER; Name: Baseline evaluation; Assigned to Arm(s): Ketamine, Placebo/Control | Intervention Type: DRUG; Name: 1st perfusion of ketamine; Assigned to Arm(s): Ketamine | Intervention Type: DRUG; Name: 1st perfusion of saline; Assigned to Arm(s): Placebo/Control | Intervention Type: OTHER; Name: Follow-up between perfusions; Assigned to Arm(s): Ketamine, Placebo/Control | Intervention Type: DRUG; Name: 2nd perfusion of ketamine; Assigned to Arm(s): Ketamine | Intervention Type: DRUG; Name: 2nd perfusion of saline; Assigned to Arm(s): Placebo/Control
B: Arm Label: 1; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Drug: Quetiapine fumarate | Intervention Type: DRUG; Name: Quetiapine fumarate; Assigned to Arm(s): 2 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): 1
C: Intervention Type: DRUG; Name: Topiramate; Assigned to Arm(s): N/A
D: Arm Label: Telephone-based management; Type: EXPERIMENTAL; Interventions: Behavioral: Treatment as Usual | Arm Label: iFightDepression for Suicide; Type: EXPERIMENTAL; Interventions: Behavioral: Treatment as Usual | Arm Label: Treatment as Usual; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Telephone-based management, Behavioral: iFightDepression for Suicide | Arm Label: Self Awareness of Mental Health; Type: EXPERIMENTAL; Interventions: Behavioral: Treatment as Usual, Behavioral: Self Awareness of Mental Health | Intervention Type: BEHAVIORAL; Name: Telephone-based management; Assigned to Arm(s): Treatment as Usual | Intervention Type: BEHAVIORAL; Name: iFightDepression for Suicide; Assigned to Arm(s): Treatment as Usual | Intervention Type: BEHAVIORAL; Name: Treatment as Usual; Assigned to Arm(s): Self Awareness of Mental Health, Telephone-based management, iFightDepression for Suicide | Intervention Type: BEHAVIORAL; Name: Self Awareness of Mental Health; Assigned to Arm(s): Self Awareness of Mental Health

Answer: B