Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: An Open-Label Multicenter, Randomized, Phase 3 Study of S-1 in Combination With Cisplatin Against 5-Fu in Combination W/ Cisplatin in Patients W/ Advanced Gastric Cancer Previously Untreated W/ Chemotherapy for Advanced Disease
Brief Summary: This is an open-label, international, two-arm, parallel, randomized, Phase 3 study evaluating the efficacy and safety of S-1/cisplatin versus 5-FU/cisplatin in patients with advanced gastric cancer previously untreated with chemotherapy for advanced disease. Patients will be randomly assigned (1:1) to S-1/cisplatin (experimental arm) or 5-FU/cisplatin (control arm). Patients will be stratified by number of metastatic sites (one vs. more than one), locally advanced or metastatic disease, prior adjuvant therapy (yes or no), measurable or non-measurable disease, and center.


Options:
A: Arm Label: Surgery + HIPEC + Systemic Chemotherapy; Type: EXPERIMENTAL; Interventions: Drug: Oxaliplatin, Drug: Irinotecan, Drug: 5-Fluorouracil, Drug: Leucovorin, Procedure: Gastrectomy and/or metastasectomy | Arm Label: Systemic Chemotherapy Alone; Type: EXPERIMENTAL; Interventions: Drug: Oxaliplatin, Drug: Irinotecan, Drug: 5-Fluorouracil, Drug: Leucovorin | Intervention Type: DRUG; Name: Oxaliplatin; Assigned to Arm(s): Surgery + HIPEC + Systemic Chemotherapy, Systemic Chemotherapy Alone | Intervention Type: DRUG; Name: Irinotecan; Assigned to Arm(s): Surgery + HIPEC + Systemic Chemotherapy, Systemic Chemotherapy Alone | Intervention Type: DRUG; Name: 5-Fluorouracil; Assigned to Arm(s): Surgery + HIPEC + Systemic Chemotherapy, Systemic Chemotherapy Alone | Intervention Type: DRUG; Name: Leucovorin; Assigned to Arm(s): Surgery + HIPEC + Systemic Chemotherapy, Systemic Chemotherapy Alone | Intervention Type: PROCEDURE; Name: Gastrectomy and/or metastasectomy; Assigned to Arm(s): Surgery + HIPEC + Systemic Chemotherapy
B: Arm Label: A; Type: ACTIVE_COMPARATOR; Interventions: Drug: S-1/Cisplatin | Arm Label: B; Type: ACTIVE_COMPARATOR; Interventions: Drug: 5-FU/cisplatin | Intervention Type: DRUG; Name: S-1/Cisplatin; Assigned to Arm(s): A | Intervention Type: DRUG; Name: 5-FU/cisplatin; Assigned to Arm(s): B
C: Arm Label: ramucirumab; Type: EXPERIMENTAL; Interventions: Biological: ramucirumab, Other: Best Supportive Care (BSC) | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Other: Best Supportive Care (BSC) | Intervention Type: BIOLOGICAL; Name: ramucirumab; Assigned to Arm(s): ramucirumab | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo | Intervention Type: OTHER; Name: Best Supportive Care (BSC); Assigned to Arm(s): Placebo, ramucirumab
D: Arm Label: Trastuzumab, Fluoropyrimidine, Cisplatin; Type: EXPERIMENTAL; Interventions: Drug: Trastuzumab, Drug: Fluorouracil, Drug: Cisplatin, Drug: Capecitabine | Arm Label: Fluoropyrimidine, Cisplatin; Type: ACTIVE_COMPARATOR; Interventions: Drug: Fluorouracil, Drug: Cisplatin, Drug: Capecitabine | Intervention Type: DRUG; Name: Trastuzumab; Assigned to Arm(s): Trastuzumab, Fluoropyrimidine, Cisplatin | Intervention Type: DRUG; Name: Fluorouracil; Assigned to Arm(s): Fluoropyrimidine, Cisplatin, Trastuzumab, Fluoropyrimidine, Cisplatin | Intervention Type: DRUG; Name: Cisplatin; Assigned to Arm(s): Fluoropyrimidine, Cisplatin, Trastuzumab, Fluoropyrimidine, Cisplatin | Intervention Type: DRUG; Name: Capecitabine; Assigned to Arm(s): Fluoropyrimidine, Cisplatin, Trastuzumab, Fluoropyrimidine, Cisplatin

Answer: B