Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Examination of Palonosetron and Hydroxyzine Pre-treatment as a Possible Method to Reduce the Objective Signs of Experimentally-induced Acute Opioid Withdrawal in Humans: a Double-blind, Randomized, Placebo-controlled Crossover Study
Brief Summary: Opioid medications are commonly used for pain relief. When given over time, physical dependence can occur. This results in unpleasant side effects--such as agitation and nausea--if opioid medications are suddenly stopped. We are interested in knowing if a medication named Ondansetron can help ease or prevent symptoms associated with opioid withdrawal. We are also interested in knowing if a similar (but more potent FDA-approved drug, palonosetron) can more effectively treat withdrawal symptoms with or without combination with an antihistamine called hydroxyzine (vistaril).


Options:
A: Arm Label: Sequence 1: Placebo, Combo, Palonosetron; Type: EXPERIMENTAL; Interventions: Drug: Palonosetron, Drug: Hydroxyzine, Other: Placebo | Arm Label: Sequence 2: Palonosetron, Combo, Placebo; Type: EXPERIMENTAL; Interventions: Drug: Palonosetron, Drug: Hydroxyzine, Other: Placebo | Arm Label: Sequence 3: Combo, Placebo, Palonosetron; Type: EXPERIMENTAL; Interventions: Drug: Palonosetron, Drug: Hydroxyzine, Other: Placebo | Arm Label: Sequence 4: Placebo, Palonosetron, Combo; Type: EXPERIMENTAL; Interventions: Drug: Palonosetron, Drug: Hydroxyzine, Other: Placebo | Arm Label: Sequence 5: Combo, Palonosetron, Placebo; Type: EXPERIMENTAL; Interventions: Drug: Palonosetron, Drug: Hydroxyzine, Other: Placebo | Arm Label: Sequence 6: Palonosetron, Placebo, Combo; Type: EXPERIMENTAL; Interventions: Drug: Palonosetron, Drug: Hydroxyzine, Other: Placebo | Intervention Type: DRUG; Name: Palonosetron; Assigned to Arm(s): Sequence 1: Placebo, Combo, Palonosetron, Sequence 2: Palonosetron, Combo, Placebo, Sequence 3: Combo, Placebo, Palonosetron, Sequence 4: Placebo, Palonosetron, Combo, Sequence 5: Combo, Palonosetron, Placebo, Sequence 6: Palonosetron, Placebo, Combo | Intervention Type: DRUG; Name: Hydroxyzine; Assigned to Arm(s): Sequence 1: Placebo, Combo, Palonosetron, Sequence 2: Palonosetron, Combo, Placebo, Sequence 3: Combo, Placebo, Palonosetron, Sequence 4: Placebo, Palonosetron, Combo, Sequence 5: Combo, Palonosetron, Placebo, Sequence 6: Palonosetron, Placebo, Combo | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Sequence 1: Placebo, Combo, Palonosetron, Sequence 2: Palonosetron, Combo, Placebo, Sequence 3: Combo, Placebo, Palonosetron, Sequence 4: Placebo, Palonosetron, Combo, Sequence 5: Combo, Palonosetron, Placebo, Sequence 6: Palonosetron, Placebo, Combo
B: Arm Label: Buprenorphine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Buprenorphine, Drug: Vivitrol | Arm Label: Oral naltrexone; Type: ACTIVE_COMPARATOR; Interventions: Drug: oral naltrexone, Drug: Buprenorphine, Drug: Vivitrol | Intervention Type: DRUG; Name: oral naltrexone; Assigned to Arm(s): Oral naltrexone | Intervention Type: DRUG; Name: Buprenorphine; Assigned to Arm(s): Buprenorphine, Oral naltrexone | Intervention Type: DRUG; Name: Vivitrol; Assigned to Arm(s): Buprenorphine, Oral naltrexone
C: Intervention Type: DRUG; Name: Buprenorphine/naloxone; Assigned to Arm(s): N/A
D: Arm Label: Treatment as usual; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Linkage; Type: EXPERIMENTAL; Interventions: Behavioral: Linkage | Intervention Type: BEHAVIORAL; Name: Linkage; Assigned to Arm(s): Linkage

Answer: A