Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Extended Follow-up of a Randomized Placebo-controlled Trial of Local Steroid Injection in Carpal Tunnel Syndrome
Brief Summary: Between 2008 and 2012 the investigators performed a single-center randomized double-blind placebo-controlled trial to assess the efficacy of local injection of two different doses of methylprednisolone (80 mg and 40 mg) in patients with carpal tunnel syndrome (CTS), aged 18 to 70 years, not previously treated with steroid injection. The primary outcomes were change in the CTS symptom severity score at 10 weeks and rate of carpal tunnel release surgery on the study hand at 1 year. In the trial 111 patients were randomized (37 in each of the 3 groups: 80 mg methylprednisolone, 40 mg methylprednisolone and placebo) and all completed the 1-year follow-up. The investiators plan an extended follow-up 5 to 7 years after injection.


Options:
A: Arm Label: Tocilizumab + Methotrexate; Type: EXPERIMENTAL; Interventions: Drug: methotrexate, Drug: tocilizumab [RoActemra/Actemra] | Arm Label: Tocilizumab + Placebo Methotrexate; Type: ACTIVE_COMPARATOR; Interventions: Drug: placebo MTX, Drug: tocilizumab [RoActemra/Actemra] | Arm Label: Methotrexate + Placebo Tocilizumab; Type: ACTIVE_COMPARATOR; Interventions: Drug: methotrexate, Drug: placebo TCZ | Intervention Type: DRUG; Name: methotrexate; Assigned to Arm(s): Methotrexate + Placebo Tocilizumab, Tocilizumab + Methotrexate | Intervention Type: DRUG; Name: placebo MTX; Assigned to Arm(s): Tocilizumab + Placebo Methotrexate | Intervention Type: DRUG; Name: placebo TCZ; Assigned to Arm(s): Methotrexate + Placebo Tocilizumab | Intervention Type: DRUG; Name: tocilizumab [RoActemra/Actemra]; Assigned to Arm(s): Tocilizumab + Methotrexate, Tocilizumab + Placebo Methotrexate
B: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Procedure: Early Carpal Tunnel Release for Mild or Moderate CTS, Other: MR Nerve Imaging for CTS | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Early Carpal Tunnel Release for Mild or Moderate CTS, Other: MR Nerve Imaging for CTS | Intervention Type: PROCEDURE; Name: Early Carpal Tunnel Release for Mild or Moderate CTS; Assigned to Arm(s): 1, 2 | Intervention Type: OTHER; Name: MR Nerve Imaging for CTS; Assigned to Arm(s): 1, 2
C: Arm Label: A; Type: ACTIVE_COMPARATOR; Interventions: Drug: Methylprednisolone 40 mg | Arm Label: B; Type: ACTIVE_COMPARATOR; Interventions: Drug: Methylprednisolone 80 mg | Arm Label: C; Type: PLACEBO_COMPARATOR; Interventions: Drug: Sodium chloride | Intervention Type: DRUG; Name: Methylprednisolone 40 mg; Assigned to Arm(s): A | Intervention Type: DRUG; Name: Methylprednisolone 80 mg; Assigned to Arm(s): B | Intervention Type: DRUG; Name: Sodium chloride; Assigned to Arm(s): C
D: Arm Label: Methylprednisolone 80 mg; Type: EXPERIMENTAL; Interventions: Drug: Methylprednisolone 80 mg | Arm Label: Methylprednisolone 40 mg; Type: EXPERIMENTAL; Interventions: Drug: Methylprednisolone 40 mg | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: Saline | Intervention Type: DRUG; Name: Methylprednisolone 80 mg; Assigned to Arm(s): Methylprednisolone 80 mg | Intervention Type: DRUG; Name: Methylprednisolone 40 mg; Assigned to Arm(s): Methylprednisolone 40 mg | Intervention Type: OTHER; Name: Saline; Assigned to Arm(s): Placebo

Answer: D