Please select the eligibility criteria that correspond to the clinical trial below.
Title: Metabolic Adaptations to Six Month Caloric Restriction
Brief Summary: This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet improves biomarkers of aging and prevents some age-related chronic diseases such as cancer, diabetes, and cardiovascular disease. The three sites that are participating in the CALERIE trial represent a diversity of subject populations and interventional strategies.


Options:
A: Inclusion Criteria:

* Non-smoking, healthy, but overweight/obese men and women with no known cardiovascular or metabolic diseases as assessed by a medical history and a comprehensive medical examination by their physicians
* Sedentary or lightly active (\<30 min, 2d/wk of structured physical activity) as assessed by a Physical Activity questionnaire
* Overweight or obese (BMI\>27.5 kg/m2; % body fat\>30%)
* Weight stable (+/-2kg) for at least 6 months prior to beginning the study

Exclusion Criteria:

* History of cardiometabolic disease (e.g. diabetes, heart disease, etc) and/or cancer and presently taking medications for these conditions
* Pregnant or may be pregnant, are allergic to milk products or are anorexic or bulimic
B: Inclusion Criteria:

* age \>= 18 years
* recurrence of a histologically confirmed glioblastoma or gliosarcoma
* at least 6 months after first surgery
* at least 6 months after first radiotherapy
* interdisciplinary recommendation for reirradiation
* karnofsky performance status \>= 60, ECOG \<= 2
* creatinine \<= 2,0 mg/dl, urea \<= 100 mg/dl
* ALAT, ASAT \<= 7x upper normal limit

Exclusion Criteria:

* bowel obstruction, subileus
* insulin-dependent diabetes
* decompensated heart failure (NYHA \> 2)
* myocardial infarction within the last 6 months, symptomatic atrial fibrillation
* severe acute infection
* malnutrition, cachexia
* other medical conditions that might increase the risk of the dietary intervention
* pregnancy
* uncontrolled thyroid function
* pancreatic insufficiency
* dementia or other clinically relevant alterations of the mental status which could impair the ability of the patient to apply to the diet or understand the informed consent of the study
C: Inclusion Criteria:

* Resident of greater Baton Rouge area for 1 year or longer
* Men between ages 25-50
* Women between ages 25-45
* Body Mass Index (BMI) between 25-30 (never having had BMI greater than 32)
* Healthy, non-smokers with no history of cardiovascular disease, high blood pressure, diabetes, eating disorder, or major psychiatric disorder

Exclusion Criteria:

* Pregnant or breastfeeding
* Personal history of cardiovascular disease or elevated high blood pressure (higher than 160/90 mmHg)
* Abnormal electrocardiogram (EKG)
* Personal history of diabetes
* Personal history of major psychiatric disorders
* Personal history of eating disorder
* Smoking
* Exercising regularly (more than twice a week)
* Individuals with alcoholism or other substance abuse
* Post obese (never have had a BMI greater than 32)
* Regular use of medications, except oral contraceptives
* Individuals who were ever injured by a metallic foreign body which was not removed
* Individuals who wear braces on their teeth, have non-removable false teeth, or non-removable bridgework
* Individuals in occupations requiring full alertness and motor skills (airline pilots, etc.) where even a small chance of postural dizziness would be unacceptable.
D: Inclusion Criteria:

* Females;
* Aged between 18 and 59 years old;
* Body mass index equal or greater 25 kg/m²;
* Agree to sign the informed consent.

Exclusion Criteria:

* Any chronic health conditions (e.g. chronic renal failure, autoimmune, heart, and liver disease);
* Thyroid diseases or medications for its treatment;
* Medications known to affect total energy expenditure;
* Use of steroids, immunosuppressants or non-steroidal anti-inflammatory drugs, weight-loss medications, oral hypoglycemic agents or insulin and any medications that influence metabolic and/or inflammatory parameters;
* Previous surgery for weight loss;
* Pregnancy or breast-feeding;
* Smoking;
* Alcohol use (\>2 doses/day).

Answer: C