Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase 3, Randomized, Controlled, Open-label Study of VELCADE (Bortezomib) Melphalan-Prednisone (VMP) Compared to Daratumumab in Combination With VMP (D-VMP), in Subjects With Previously Untreated Multiple Myeloma Who Are Ineligible for High-dose Therapy
Brief Summary: The purpose of this study is to determine if the addition of daratumumab to velcade (bortezomib) melphalan-prednisone (VMP) will prolong progression-free survival (PFS) compared with VMP alone in participants with previously untreated multiple myeloma who are ineligible for high dose chemotherapy and autologous stem cell transplant (ASCT).


Options:
A: Arm Label: Part 1: VMP+Siltuximab 11 mg/kg; Type: EXPERIMENTAL; Interventions: Drug: Siltuximab11 mg/kg, Drug: Velcade (bortezomib), Drug: Melphalan, Drug: Prednisone | Arm Label: Part 2, Arm A: VMP+Siltuximab 8.3 mg/kg or 11 mg/kg; Type: EXPERIMENTAL; Interventions: Drug: Siltuximab 8.3 mg/kg or 11 mg/kg, Drug: Velcade (bortezomib), Drug: Melphalan, Drug: Prednisone | Arm Label: Part 2, Arm B: VMP; Type: ACTIVE_COMPARATOR; Interventions: Drug: Velcade (bortezomib), Drug: Melphalan, Drug: Prednisone | Intervention Type: DRUG; Name: Siltuximab11 mg/kg; Assigned to Arm(s): Part 1: VMP+Siltuximab 11 mg/kg | Intervention Type: DRUG; Name: Siltuximab 8.3 mg/kg or 11 mg/kg; Assigned to Arm(s): Part 2, Arm A: VMP+Siltuximab 8.3 mg/kg or 11 mg/kg | Intervention Type: DRUG; Name: Velcade (bortezomib); Assigned to Arm(s): Part 1: VMP+Siltuximab 11 mg/kg | Intervention Type: DRUG; Name: Velcade (bortezomib); Assigned to Arm(s): Part 2, Arm A: VMP+Siltuximab 8.3 mg/kg or 11 mg/kg | Intervention Type: DRUG; Name: Melphalan; Assigned to Arm(s): Part 1: VMP+Siltuximab 11 mg/kg | Intervention Type: DRUG; Name: Melphalan; Assigned to Arm(s): Part 2, Arm A: VMP+Siltuximab 8.3 mg/kg or 11 mg/kg | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): Part 1: VMP+Siltuximab 11 mg/kg | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): Part 2, Arm A: VMP+Siltuximab 8.3 mg/kg or 11 mg/kg | Intervention Type: DRUG; Name: Velcade (bortezomib); Assigned to Arm(s): Part 2, Arm B: VMP | Intervention Type: DRUG; Name: Melphalan; Assigned to Arm(s): Part 2, Arm B: VMP | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): Part 2, Arm B: VMP
B: Arm Label: A (Thalidomide & Dexamethasone); Type: EXPERIMENTAL; Interventions: Drug: A (Thalidomide + Dexamethasone) | Arm Label: B (Dexamethasone and placebo); Type: PLACEBO_COMPARATOR; Interventions: Drug: B (Placebo + Dexamethasone) | Intervention Type: DRUG; Name: A (Thalidomide + Dexamethasone); Assigned to Arm(s): A (Thalidomide & Dexamethasone) | Intervention Type: DRUG; Name: B (Placebo + Dexamethasone); Assigned to Arm(s): B (Dexamethasone and placebo)
C: Arm Label: Treatment Arm A (VMP Alone); Type: ACTIVE_COMPARATOR; Interventions: Drug: Velcade, Drug: Melphalan, Drug: Prednisone | Arm Label: Treatment Arm B (D-VMP); Type: EXPERIMENTAL; Interventions: Drug: Velcade, Drug: Melphalan, Drug: Prednisone, Drug: Daratumumab IV, Drug: Dexamethasone, Drug: Daratumumab SC | Intervention Type: DRUG; Name: Velcade; Assigned to Arm(s): Treatment Arm A (VMP Alone), Treatment Arm B (D-VMP) | Intervention Type: DRUG; Name: Melphalan; Assigned to Arm(s): Treatment Arm A (VMP Alone), Treatment Arm B (D-VMP) | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): Treatment Arm A (VMP Alone), Treatment Arm B (D-VMP) | Intervention Type: DRUG; Name: Daratumumab IV; Assigned to Arm(s): Treatment Arm B (D-VMP) | Intervention Type: DRUG; Name: Dexamethasone; Assigned to Arm(s): Treatment Arm B (D-VMP) | Intervention Type: DRUG; Name: Daratumumab SC; Assigned to Arm(s): Treatment Arm B (D-VMP)
D: Arm Label: A; Type: PLACEBO_COMPARATOR; Interventions: Drug: thalidomide, Drug: placebo | Arm Label: B; Type: ACTIVE_COMPARATOR; Interventions: Drug: thalidomide, Drug: placebo | Intervention Type: DRUG; Name: thalidomide; Assigned to Arm(s): A, B | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): A, B

Answer: C