Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Phase III Trial Comparing Conventional Adjuvant Temozolomide With Dose-Intensive Temozolomide in Patients With Newly Diagnosed Glioblastoma
Brief Summary: RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with temozolomide may kill more tumor cells. It is not yet known which schedule of temozolomide when given together with radiation therapy is more effective in treating glioblastoma or gliosarcoma.

PURPOSE: This randomized phase III trial is studying two different schedules of temozolomide to compare how well they work when given together with radiation therapy in treating patients with newly diagnosed glioblastoma or gliosarcoma.


Options:
A: Arm Label: Cilengitide + Temozolomide + Radiotherapy; Type: EXPERIMENTAL; Interventions: Drug: Cilengitide, Drug: Temozolomide, Radiation: Radiotherapy | Arm Label: Temozolomide + Radiotherapy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Temozolomide, Radiation: Radiotherapy | Intervention Type: DRUG; Name: Cilengitide; Assigned to Arm(s): Cilengitide + Temozolomide + Radiotherapy | Intervention Type: DRUG; Name: Temozolomide; Assigned to Arm(s): Cilengitide + Temozolomide + Radiotherapy, Temozolomide + Radiotherapy | Intervention Type: RADIATION; Name: Radiotherapy; Assigned to Arm(s): Cilengitide + Temozolomide + Radiotherapy, Temozolomide + Radiotherapy
B: Arm Label: Rindopepimut/GM-CSF plus Temozolomide; Type: EXPERIMENTAL; Interventions: Drug: Rindopepimut (CDX-110) with GM-CSF, Drug: Temozolomide | Arm Label: KLH plus Temozolomide; Type: ACTIVE_COMPARATOR; Interventions: Drug: Temozolomide, Drug: KLH | Intervention Type: DRUG; Name: Rindopepimut (CDX-110) with GM-CSF; Assigned to Arm(s): Rindopepimut/GM-CSF plus Temozolomide | Intervention Type: DRUG; Name: Temozolomide; Assigned to Arm(s): KLH plus Temozolomide, Rindopepimut/GM-CSF plus Temozolomide | Intervention Type: DRUG; Name: KLH; Assigned to Arm(s): KLH plus Temozolomide
C: Arm Label: Conventional adjuvant TMZ; Type: ACTIVE_COMPARATOR; Interventions: Drug: Concurrent temozolomide, Radiation: Concurrent radiation therapy, Drug: 100mg/m2 adjuvant temozolomide days 1 to 5 of 28 day cycle | Arm Label: Dose-dense adjuvant TMZ; Type: EXPERIMENTAL; Interventions: Drug: Concurrent temozolomide, Radiation: Concurrent radiation therapy, Drug: 75mg/m2 adjuvant temozolomide days 1-21 of 28 day cycle | Arm Label: No adjuvant TMZ (not randomized ); Type: OTHER; Interventions: Drug: Concurrent temozolomide, Radiation: Concurrent radiation therapy | Intervention Type: DRUG; Name: Concurrent temozolomide; Assigned to Arm(s): Conventional adjuvant TMZ, Dose-dense adjuvant TMZ, No adjuvant TMZ (not randomized ) | Intervention Type: RADIATION; Name: Concurrent radiation therapy; Assigned to Arm(s): Conventional adjuvant TMZ, Dose-dense adjuvant TMZ, No adjuvant TMZ (not randomized ) | Intervention Type: DRUG; Name: 100mg/m2 adjuvant temozolomide days 1 to 5 of 28 day cycle; Assigned to Arm(s): Conventional adjuvant TMZ | Intervention Type: DRUG; Name: 75mg/m2 adjuvant temozolomide days 1-21 of 28 day cycle; Assigned to Arm(s): Dose-dense adjuvant TMZ
D: Arm Label: Temozolomide; Type: ACTIVE_COMPARATOR; Interventions: Drug: temozolomide, Genetic: DNA methylation analysis, Procedure: quality-of-life assessment | Arm Label: Radiation; Type: ACTIVE_COMPARATOR; Interventions: Genetic: DNA methylation analysis, Procedure: quality-of-life assessment, Radiation: Radiation | Intervention Type: DRUG; Name: temozolomide; Assigned to Arm(s): Temozolomide | Intervention Type: GENETIC; Name: DNA methylation analysis; Assigned to Arm(s): Radiation, Temozolomide | Intervention Type: PROCEDURE; Name: quality-of-life assessment; Assigned to Arm(s): Radiation, Temozolomide | Intervention Type: RADIATION; Name: Radiation; Assigned to Arm(s): Radiation

Answer: C