Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Macronutrient Composition of Diet and Risk Factors for Cardiovascular Disease
Brief Summary: The objective of this trial is to examine the long-term effects of a diet low in carbohydrates, as compared to one low in fat, on cardiovascular disease risk factors, including blood pressure (BP), body weight and composition, serum lipids, plasma glucose, insulin, adipocytokines (adiponectin, leptin, resistin), and C-reactive protein (CRP) among obese adults.

The investigators will test the following hypotheses:

Hypothesis 1: Compared to a low fat diet, a diet low in carbohydrates will reduce systolic and diastolic BP over 12 months; Hypothesis 2: Compared to a low fat diet, a diet low in carbohydrates will reduce body weight, total percent body fat, and waist circumference over 12 months; Hypothesis 3: Compared to a low fat diet, a diet low in carbohydrates will reduce serum levels of LDL-cholesterol and triglycerides and increase serum levels of HDL-cholesterol over 12 months; Hypothesis 4: Compared to a low fat diet, a diet low in carbohydrates will reduce plasma levels of glucose and insulin levels over 12 months; and Hypothesis 5: Compared to a low fat diet, a diet low in carbohydrates will reduce plasma levels of leptin, resistin, and CRP and increase plasma levels of adiponectin over 12 months.


Options:
A: Arm Label: low-fat diet; Type: EXPERIMENTAL; Interventions: Behavioral: low-fat diet | Arm Label: moderate-fat diet; Type: EXPERIMENTAL; Interventions: Behavioral: moderate-fat diet | Arm Label: high-fat diet; Type: EXPERIMENTAL; Interventions: Behavioral: high-fat diet | Intervention Type: BEHAVIORAL; Name: low-fat diet; Assigned to Arm(s): low-fat diet | Intervention Type: BEHAVIORAL; Name: moderate-fat diet; Assigned to Arm(s): moderate-fat diet | Intervention Type: BEHAVIORAL; Name: high-fat diet; Assigned to Arm(s): high-fat diet
B: Arm Label: Control; Type: EXPERIMENTAL; Interventions: Behavioral: Exercise - Aerobic and Resistance, Behavioral: Dietary - Caloric Restriction | Arm Label: Dairy Protein; Type: EXPERIMENTAL; Interventions: Behavioral: Exercise - Aerobic and Resistance, Behavioral: Dietary - Caloric Restriction | Arm Label: High Dairy Protein; Type: EXPERIMENTAL; Interventions: Behavioral: Exercise - Aerobic and Resistance, Behavioral: Dietary - Caloric Restriction | Intervention Type: BEHAVIORAL; Name: Exercise - Aerobic and Resistance; Assigned to Arm(s): Control, Dairy Protein, High Dairy Protein | Intervention Type: BEHAVIORAL; Name: Dietary - Caloric Restriction; Assigned to Arm(s): Control, Dairy Protein, High Dairy Protein
C: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Behavioral: low carbohydrate diet | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: low fat diet | Intervention Type: BEHAVIORAL; Name: low carbohydrate diet; Assigned to Arm(s): 1 | Intervention Type: BEHAVIORAL; Name: low fat diet; Assigned to Arm(s): 2
D: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: NNR (Nordic Nutrition Recommendations) | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: MPD (Modified paleolithic diet) | Intervention Type: BEHAVIORAL; Name: NNR (Nordic Nutrition Recommendations); Assigned to Arm(s): 1 | Intervention Type: BEHAVIORAL; Name: MPD (Modified paleolithic diet); Assigned to Arm(s): 2

Answer: C