Please select the eligibility criteria that correspond to the clinical trial below.
Title: Diet and Exercise in Type 2 Diabetes - a Randomized Controlled Trial
Brief Summary: The investigators investigate if combined progressive aerobic training and resistance training improve metabolic control and fat mass in patients with type 2 diabetes who are eating a modified paleolithic diet. The investigators randomize 40 participants to two groups: 1) Modified paleolithic diet and exercise under observation 3 sessions/week, 2) Modified paleolithic diet and general advice about exercise.

The investigators primary hypothesis is that in patients with type 2 diabetes decreases fat mass more with progressive exercise under observation and a modified paleolithic diet than with general advice about exercise and a modified paleolithic diet.


Options:
A: Inclusion Criteria:

* Body Mass Index \> 27 kg/m2
* No chronic medication (except oral contraceptives and L-Thyroxine) or possibility to stop medication for study duration
* Able to give written informed consent

Exclusion Criteria:

* Pregnancy and nursing
* Severe cardiovascular, liver, kidney, hepatic or orthopedic disease that need treatment
* Metabolic or endocrine disease that need treatment
* Hypertension blood pressure \> 160/95 mmHg or need of \> 2 drugs
* Previous stroke or cerebral ischemia
* Significant neurologic or psychiatric disease
* Any kind of eating disorder
* Bariatric surgery in the past
* Drug or alcohol abuse
* Any cancer in the past
* Acute and chronic infections
* Metallic implants (e.g. pace makers) or conditions that do not allow MRI scans
* Body weight \> 130 kg
B: DISEASE CHARACTERISTICS: Primary operable stage I (tumors at least 1 cm), stage II, and stage IIIA invasive breast carcinoma Treatment within the past 4 years by total mastectomy and axillary dissection, or breast sparing surgical removal of cancer with clear macroscopic margins and axillary dissection followed by adjuvant breast radiation No evidence of recurrent disease or new breast cancer since completion of initial local treatment confirmed within the past 6 months by physician evaluation, except stage I mastectomy, for which physician evaluation can be within 1 year prior to randomization Hormone receptor status: Not specified

PATIENT CHARACTERISTICS: Age: 18 to 70 at time of diagnosis Sex: Female Menopausal status: Not specified Performance status: Not specified Life expectancy: At least 10 years (excluding breast cancer) Hematopoietic: Not specified Hepatic: No cirrhosis Renal: Not specified Other: Not pregnant Accessible geographically and by telephone Able to communicate dietary data via 24-hour food recall Able to commit to the intervention schedule No comorbidity requiring a specific diet or taking a medication which contraindicates consuming a high fiber diet (e.g., systemic scleroderma, other digestive malabsorption syndromes, and insulin dependent diabetes) No other primary or recurrent invasive cancer within the past 10 years except nonmelanoma skin cancer or carcinoma in situ of the cervix

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No concurrent chemotherapy Endocrine therapy: No concurrent estrogen replacement therapy, including vaginal estrogen creams Radiotherapy: See Disease Characteristics Surgery: See Disease Characteristics Other: No concurrent enrollment in another clinical trial that has dietary restrictions or endpoints similar to this study
C: Inclusion Criteria:

* Having type 2 diabetes for at least three months prior to screening and treated with any antihyperglycemic medication
* A1C ≥7 %
* Consuming \<3 servings of dairy products per day
* On stable dose of diabetes, blood pressure or cholesterol medications for 3 months
* Body weight is within 10% of current weight over the last 6 months before starting the study

Exclusion Criteria:

* Pregnancy or lactation
* Lactose intolerance
* Allergy to milk or any of its components
* Use of orlistat
* History of pancreatitis
* History of gastric bypass surgery or sleeve gastrectomy
* Active malignancy
* History of recent cardiovascular event
* Having a heart pacemaker
* Enrollment in other studies that may affect study outcomes
D: Inclusion Criteria:

* type 2 diabetes less than 10 years
* BMI 27-35
* women only after menopause
* diabetes treatment with diet and/or metformin
* HbA1c between 45 and 94

Exclusion Criteria:

* nicotine use
* insulin
* betablockers
* estrogens orally
* blod pressure \>160/100
* macroalbuminuria
* malignancy during the past 5 years
* alcoholism
* depression
* cardiovascular disease/stroke
* liver disease
* serious lung disease, GI disease or kidney disease
* more than 30 minutes/5 days a week of moderate exercise during the last 6 months
* resistance training during the past 6 months
* official weight loosing program during the past year
* obesity surgery
* night work
* MADRS-S (Montgomery Asberg Depression Rating Scale) \>20 points
* AUDIT \>14 points for women, \>16 points for men
* not possible to obtain venous sampling

Answer: D