Please select the eligibility criteria that correspond to the clinical trial below.
Title: Efficacy of Conservative Versus Surgical Therapy for Carpal Tunnel Syndrome: a Randomised Clinical Trial
Brief Summary: It is a randomized clinical trial comparing surgical and conservative (physical therapy) treatments for women with carpal tunnel syndrome (CTS). The purpose of the study is to determine the efficacy of physical therapy versus endoscopic surgery in pain and disability in women with carpal tunnel syndrome at medium and long-term follow-up periods. We hypothesized that proper physical therapy approach can be equally effective than surgical intervention for improving pain and function in patients with carpal tunnel syndrome.


Options:
A: Inclusion Criteria:

* Paresthesias involving 2 digits on hand diagram
* Willingness and ability to complete interviews

Exclusion Criteria:

* Evidence of denervation on EDS
* Abnormal 2-pt discrimination or thenar atrophy
* Prior wrist surgery or acute external trauma
* MRI contraindications
* Metallic hardware in wrists
B: Inclusion Criteria:

* adult patients, \>/=18 years of age
* early rheumatoid arthritis (disease symptoms \<1 year) according to ACR criteria
* disease activity DAS28 \>2.6
* body weight \</=110kg, BMI \</=36

Exclusion Criteria:

* rheumatic autoimmune disease other than RA
* current inflammatory joint disease other than RA
* previous treatment with any DMARD or biologic drug used in the treatment of RA
* intra-articular, parenteral or oral glucocorticoids used for the arthritis
C: Inclusion Criteria:

* pain and paresthesia in the median nerve distribution without extra-median nerve territory symptoms;
* increasing symptoms during night;
* Tinel sign;
* Phalen sign;
* self-reported hand strength deficits.
* Deficits of sensory and motor nerve conduction of the median nerve according to standardized guidelines of the American Association of Electrodiagnosis, American Academy of Neurology, and the American Academy of Physical Medicine and Rehabilitation

Exclusion Criteria:

* if any sensory/motor deficit in ulnar or radial nerve was present;
* previous interventions with surgery or steroid injections;
* multiple diagnoses of the upper extremity (i.e., cervical radiculopathy, lateral epicondylalgia);
* history of neck, shoulder or arm trauma;
* history of a systemic disease causing CTS (e.g. diabetes mellitus, or thyroid disease);
* history of systemic musculoskeletal conditions (e.g. rheumatoid arthritis, fibromyalgia);
* if the patient was actively involved with or seeking litigation at the time of the study;
* pregnancy.
D: Inclusion Criteria:

* Primary idiopathic CTS
* Symptoms of classic or probable CTS according to the Katz diagnostic criteria (numbness and/or tingling in at least 2 of the 4 median nerve innervated fingers)
* Failed treatment with wrist splinting (2 months)
* Nerve conduction tests showing median neuropathy at the wrist or, if normal, two orthopedic surgeons independently make CTS diagnosis
* Symptom severity that warranted referral for consideration for surgery

Exclusion Criteria:

* Previous steroid injection for CTS
* Thenar muscle atrophy
* Sensory deficit (two-point discrimination \>8 mm)
* Diabetes, thyroid disorder, or inflammatory disease
* Polyneuropathy or vibration-induced neuropathy
* Current pregnancy
* Previous carpal tunnel surgery on the study hand
* Surgery on the contralateral hand in the past 2 months
* Inability to respond to questionnaires
* Severe medical illness
* Known drug/alcohol abuse

Answer: C