Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Comparison of High Dose Rapid Schedule With Conventional Schedule Chemotherapy for Stage 4 Neuroblastoma Over the Age of One Year
Brief Summary: RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Giving combination chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. A bone marrow transplant, using bone marrow from the patient, may be able to replace blood-forming cells that were destroyed by chemotherapy. It is not yet know which combination chemotherapy schedule is more effective, when given before surgery and an autologous bone marrow transplant, in treating patients with disseminated neuroblastoma.

PURPOSE: This randomized phase III trial is studying two different chemotherapy schedules to compare how well they work in treating young patients who are undergoing surgery and an autologous bone marrow transplant for disseminated neuroblastoma.


Options:
A: Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: vincristine sulfate; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): N/A
B: Intervention Type: DRUG; Name: carboplatin; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: cisplatin; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: etoposide; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: melphalan; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: vincristine sulfate; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: autologous bone marrow transplantation; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): N/A
C: Arm Label: Arm I (isotretinoin) (closed to accrual as of 4/16/2009); Type: ACTIVE_COMPARATOR; Interventions: Drug: Isotretinoin, Other: Laboratory Biomarker Analysis, Other: Pharmacological Study, Other: Quality-of-Life Assessment | Arm Label: Arm II (sargramostim, dinutuximab, aldesleukin, isotretinoin); Type: EXPERIMENTAL; Interventions: Biological: Aldesleukin, Biological: Dinutuximab, Drug: Isotretinoin, Other: Laboratory Biomarker Analysis, Other: Pharmacological Study, Other: Quality-of-Life Assessment, Biological: Sargramostim | Intervention Type: BIOLOGICAL; Name: Aldesleukin; Assigned to Arm(s): Arm II (sargramostim, dinutuximab, aldesleukin, isotretinoin) | Intervention Type: BIOLOGICAL; Name: Dinutuximab; Assigned to Arm(s): Arm II (sargramostim, dinutuximab, aldesleukin, isotretinoin) | Intervention Type: DRUG; Name: Isotretinoin; Assigned to Arm(s): Arm I (isotretinoin) (closed to accrual as of 4/16/2009), Arm II (sargramostim, dinutuximab, aldesleukin, isotretinoin) | Intervention Type: OTHER; Name: Laboratory Biomarker Analysis; Assigned to Arm(s): Arm I (isotretinoin) (closed to accrual as of 4/16/2009), Arm II (sargramostim, dinutuximab, aldesleukin, isotretinoin) | Intervention Type: OTHER; Name: Pharmacological Study; Assigned to Arm(s): Arm I (isotretinoin) (closed to accrual as of 4/16/2009), Arm II (sargramostim, dinutuximab, aldesleukin, isotretinoin) | Intervention Type: OTHER; Name: Quality-of-Life Assessment; Assigned to Arm(s): Arm I (isotretinoin) (closed to accrual as of 4/16/2009), Arm II (sargramostim, dinutuximab, aldesleukin, isotretinoin) | Intervention Type: BIOLOGICAL; Name: Sargramostim; Assigned to Arm(s): Arm II (sargramostim, dinutuximab, aldesleukin, isotretinoin)
D: Arm Label: Arm I (unpurged PBSC collection); Type: EXPERIMENTAL; Interventions: Biological: filgrastim, Drug: carboplatin, Drug: cisplatin, Drug: cyclophosphamide, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: isotretinoin, Drug: melphalan, Drug: topotecan hydrochloride, Drug: vincristine sulfate, Procedure: autologous bone marrow transplantation, Procedure: bone marrow ablation with stem cell support, Procedure: conventional surgery, Procedure: peripheral blood stem cell transplantation, Radiation: radiation therapy | Arm Label: Arm II (unpurged PBSC collection); Type: EXPERIMENTAL; Interventions: Drug: carboplatin, Drug: cisplatin, Drug: cyclophosphamide, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: isotretinoin, Drug: melphalan, Drug: topotecan hydrochloride, Drug: vincristine sulfate, Procedure: autologous bone marrow transplantation, Procedure: bone marrow ablation with stem cell support, Procedure: conventional surgery, Procedure: peripheral blood stem cell transplantation, Radiation: radiation therapy | Intervention Type: BIOLOGICAL; Name: filgrastim; Assigned to Arm(s): Arm I (unpurged PBSC collection) | Intervention Type: DRUG; Name: carboplatin; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: cisplatin; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: etoposide; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: isotretinoin; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: melphalan; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: topotecan hydrochloride; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: DRUG; Name: vincristine sulfate; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: PROCEDURE; Name: autologous bone marrow transplantation; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: PROCEDURE; Name: bone marrow ablation with stem cell support; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: PROCEDURE; Name: peripheral blood stem cell transplantation; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection) | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): Arm I (unpurged PBSC collection), Arm II (unpurged PBSC collection)

Answer: B