TrialPanorama/Dataset huggingface dataset:
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Comparing Air Insufflation, Water Immersion and Water Exchange Methods During Minimal Sedated Colonoscopy, a Randomized, Controlled Trial
Brief Summary: In minimally sedated Asian patients in a community setting the investigators showed that a limited volume of water infusion instead of air insufflation in either the rectal sigmoid colon or the whole colon significantly reduced pain score during colonoscopy. Cecal intubation rate was not compromised. The reduction of pain score ranges from 25% to 32 % in our previous studies.1, 2 In contrast, several US reports described the successful use larger volumes of water infused throughout the entire colon in patients undergoing colonoscopy which result in a greater reduction of the pain score, averaging about 56%.3-5 A recent review suggested that the cause of the difference might lies in the timing of water removal.6 Specifically, the investigators group removed the infused water predominantly during withdrawal phase (water immersion) and the U.S. group removed water during insertion phase (water exchange).

This prospective, randomized controlled trial compared water exchange or water immersion with traditional air insufflation in patients undergoing minimally sedated colonoscopy. The investigators test the hypothesis that water exchange can reduce more pain than water immersion in the investigators clinical setting.


Options:
A: Arm Label: CO2; Type: EXPERIMENTAL; Interventions: Procedure: CO2 | Arm Label: Warm Water irrigation; Type: EXPERIMENTAL; Interventions: Procedure: Warm water | Intervention Type: PROCEDURE; Name: CO2; Assigned to Arm(s): CO2 | Intervention Type: PROCEDURE; Name: Warm water; Assigned to Arm(s): Warm Water irrigation
B: Arm Label: Arm 1: Study Treatment; Type: EXPERIMENTAL; Interventions: Procedure: Colonoscopy | Arm Label: Arm 2: Control Treatment; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: PROCEDURE; Name: Colonoscopy; Assigned to Arm(s): Arm 1: Study Treatment
C: Arm Label: Water Immersion Colonoscopy; Type: EXPERIMENTAL; Interventions: Procedure: water immersion colonoscopy | Arm Label: Standard Air Colonoscopy; Type: ACTIVE_COMPARATOR; Interventions: Procedure: standard air colonoscopy | Intervention Type: PROCEDURE; Name: water immersion colonoscopy; Assigned to Arm(s): Water Immersion Colonoscopy | Intervention Type: PROCEDURE; Name: standard air colonoscopy; Assigned to Arm(s): Standard Air Colonoscopy
D: Arm Label: air insufflation; Type: PLACEBO_COMPARATOR; Interventions: Procedure: air insufflation | Arm Label: water immersion; Type: ACTIVE_COMPARATOR; Interventions: Procedure: water immersion | Arm Label: water exchange; Type: ACTIVE_COMPARATOR; Interventions: Procedure: water exchange | Intervention Type: PROCEDURE; Name: air insufflation; Assigned to Arm(s): air insufflation | Intervention Type: PROCEDURE; Name: water immersion; Assigned to Arm(s): water immersion | Intervention Type: PROCEDURE; Name: water exchange; Assigned to Arm(s): water exchange

Answer: D
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Evaluation of Sleep Position Trainer for Positional Sleep Apnea Patients After Therapy With Mandibular Advancement Device (MAD)
Brief Summary: The investigators will perform a clinical trial comparing mandibular advancement device (MAD) therapy with sleep positional trainer (SPT) and the combination of MAD and SPT in patients with positional sleep apnea using MAD. Patients are invited for 2 consecutive polysomnographies (PSGs) in randomized order: one PSG with SPT, one PSG with SPT and MAD. PSGs are performed at the Antwerp University Hospital.


Options:
A: Arm Label: Elevated body position; Type: ACTIVE_COMPARATOR; Interventions: Procedure: elevated body position | Arm Label: supine body position; Type: ACTIVE_COMPARATOR; Interventions: Procedure: supine body position | Intervention Type: PROCEDURE; Name: elevated body position; Assigned to Arm(s): Elevated body position | Intervention Type: PROCEDURE; Name: supine body position; Assigned to Arm(s): supine body position
B: Arm Label: Sleep position trainer; Type: EXPERIMENTAL; Interventions: Device: sleep position trainer | Arm Label: Oral Appliance Therapy; Type: ACTIVE_COMPARATOR; Interventions: Device: Oral Appliance Therapy | Intervention Type: DEVICE; Name: sleep position trainer; Assigned to Arm(s): Sleep position trainer | Intervention Type: DEVICE; Name: Oral Appliance Therapy; Assigned to Arm(s): Oral Appliance Therapy
C: Arm Label: SPT in patients with MAD; Type: OTHER; Interventions: Device: Sleep Position Trainer (SPT) | Intervention Type: DEVICE; Name: Sleep Position Trainer (SPT); Assigned to Arm(s): SPT in patients with MAD
D: Intervention Type: DEVICE; Name: Nasal CPAP (Continuous Positive Airway Pressure); Assigned to Arm(s): N/A

Answer: C
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Oral Paracetamol Versus Oral Ibuprofen Treatment
Brief Summary: The purpose of this study is to determine whether oral paracetamol or ibuprofen has a better or same efficacy and tolerance in closure of patent ductus arteriosus in preterm infants.


Options:
A: Arm Label: early ibuprofen; Type: EXPERIMENTAL; Interventions: Drug: Early ibuprofen | Arm Label: Late Ibuprofen expectant group (placebo); Type: OTHER; Interventions: Other: Late ibuprofen expectant group (placebo) | Intervention Type: DRUG; Name: Early ibuprofen; Assigned to Arm(s): early ibuprofen | Intervention Type: OTHER; Name: Late ibuprofen expectant group (placebo); Assigned to Arm(s): Late Ibuprofen expectant group (placebo)
B: Arm Label: Oral paracetamol; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oral paracetamol | Arm Label: Oral ibuprofen; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oral ibuprofen | Intervention Type: DRUG; Name: Oral paracetamol; Assigned to Arm(s): Oral paracetamol | Intervention Type: DRUG; Name: Oral ibuprofen; Assigned to Arm(s): Oral ibuprofen
C: Arm Label: Early Treatment with cyclooxygenase inhibitors; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ibuprofen, Drug: Indomethacin | Arm Label: Expectative Treatment; Type: SHAM_COMPARATOR; Interventions: Other: Expectative Management | Intervention Type: DRUG; Name: Ibuprofen; Assigned to Arm(s): Early Treatment with cyclooxygenase inhibitors | Intervention Type: OTHER; Name: Expectative Management; Assigned to Arm(s): Expectative Treatment | Intervention Type: DRUG; Name: Indomethacin; Assigned to Arm(s): Early Treatment with cyclooxygenase inhibitors
D: Arm Label: I; Type: ACTIVE_COMPARATOR; Interventions: Drug: intravenous ibuprofen | Arm Label: O; Type: ACTIVE_COMPARATOR; Interventions: Drug: oral ibuprofen | Intervention Type: DRUG; Name: oral ibuprofen; Assigned to Arm(s): O | Intervention Type: DRUG; Name: intravenous ibuprofen; Assigned to Arm(s): I

Answer: B
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Oral Paracetamol Versus Oral Ibuprofen Treatment
Brief Summary: The purpose of this study is to determine whether oral paracetamol or ibuprofen has a better or same efficacy and tolerance in closure of patent ductus arteriosus in preterm infants.


Options:
A: Arm Label: Oral paracetamol; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oral paracetamol | Arm Label: Oral ibuprofen; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oral ibuprofen | Intervention Type: DRUG; Name: Oral paracetamol; Assigned to Arm(s): Oral paracetamol | Intervention Type: DRUG; Name: Oral ibuprofen; Assigned to Arm(s): Oral ibuprofen
B: Arm Label: ACS (Group 1); Type: ACTIVE_COMPARATOR; Interventions: Drug: Betamethason Sodium Phosphate | Arm Label: Placebo (Group 2); Type: PLACEBO_COMPARATOR; Interventions: Drug: Normal saline | Intervention Type: DRUG; Name: Betamethason Sodium Phosphate; Assigned to Arm(s): ACS (Group 1) | Intervention Type: DRUG; Name: Normal saline; Assigned to Arm(s): Placebo (Group 2)
C: Arm Label: Paracetamol; Type: EXPERIMENTAL; Interventions: Drug: Paracetamol | Arm Label: Ibuprofen; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ibuprofen | Intervention Type: DRUG; Name: Paracetamol; Assigned to Arm(s): Paracetamol | Intervention Type: DRUG; Name: Ibuprofen; Assigned to Arm(s): Ibuprofen
D: Arm Label: Ibuprofen group; Type: N/A; Interventions: Drug: Ibuprofen (Sanofi, Istanbul, Turkey) | Arm Label: Paracetamol group; Type: N/A; Interventions: Drug: Paracetamol (GlaxoSmithKline, Istanbul, Turkey) | Intervention Type: DRUG; Name: Ibuprofen (Sanofi, Istanbul, Turkey); Assigned to Arm(s): Ibuprofen group | Intervention Type: DRUG; Name: Paracetamol (GlaxoSmithKline, Istanbul, Turkey); Assigned to Arm(s): Paracetamol group

Answer: A
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Impact of Early Parenteral Nutrition Completing Enteral Nutrition in Paediatric Critically Ill Patients
Brief Summary: In the PEPaNIC trial it is investigated whether withholding parenteral nutrition during the first week in critically ill children is beneficial, compared to the current standard of the early start of parenteral nutrition.


Options:
A: Arm Label: Early parenteral nutrition; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Late parenteral nutrition; Type: EXPERIMENTAL; Interventions: Other: Late parenteral nutrition | Intervention Type: OTHER; Name: Late parenteral nutrition; Assigned to Arm(s): Late parenteral nutrition
B: Arm Label: Group A; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Preterm infants formula A | Arm Label: Group B; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Preterm infants formula B | Intervention Type: DIETARY_SUPPLEMENT; Name: Preterm infants formula A; Assigned to Arm(s): Group A | Intervention Type: DIETARY_SUPPLEMENT; Name: Preterm infants formula B; Assigned to Arm(s): Group B
C: Arm Label: A; Type: ACTIVE_COMPARATOR; Interventions: Drug: conventional insulin therapy (Actrapid IV only for excessive hyperglycemia) | Arm Label: B; Type: EXPERIMENTAL; Interventions: Drug: intensive insulin therapy (Actrapid IV to normoglycemia) | Intervention Type: DRUG; Name: intensive insulin therapy (Actrapid IV to normoglycemia); Assigned to Arm(s): B | Intervention Type: DRUG; Name: conventional insulin therapy (Actrapid IV only for excessive hyperglycemia); Assigned to Arm(s): A
D: Arm Label: Tight Glycemic Control 1 (TGC-1); Type: ACTIVE_COMPARATOR; Interventions: Drug: Insulin | Arm Label: Tight Glycemic Control 2 (TGC-2); Type: ACTIVE_COMPARATOR; Interventions: Drug: Insulin | Intervention Type: DRUG; Name: Insulin; Assigned to Arm(s): Tight Glycemic Control 1 (TGC-1) | Intervention Type: DRUG; Name: Insulin; Assigned to Arm(s): Tight Glycemic Control 2 (TGC-2)

Answer: A
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Can Rhodiola Crenulata Intake Improve Oxygen Saturation and Decrease the Incidence of Acute Mountain Sickness.
Brief Summary: Traditional folk medicine in the Arctic and Himalayan areas used Rhodiola species to enhance physical endurance, prevent aging, resist acute mountain sickness (AMS), and to treat fatigue, depression, anemia, impotence and respiratory infections. Rhodiola crenulata are widely used to prevent AMS in Himalayan areas and Lhasa in Tibet but none was examined by human study. The investigators conducted a randomized, double blind, placebo controlled, crossover study to investigate the efficacy of Rhodiola crenulata in preventing AMS.


Options:
A: Arm Label: Rhodiola crenulata-placebo sequence; Type: ACTIVE_COMPARATOR; Interventions: Drug: Rhodiola crenulata, Drug: placebo | Arm Label: Placebo-Rhodiola crenulata sequence; Type: ACTIVE_COMPARATOR; Interventions: Drug: Rhodiola crenulata, Drug: placebo | Intervention Type: DRUG; Name: Rhodiola crenulata; Assigned to Arm(s): Placebo-Rhodiola crenulata sequence, Rhodiola crenulata-placebo sequence | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Placebo-Rhodiola crenulata sequence, Rhodiola crenulata-placebo sequence
B: Arm Label: Dexamethasone; Type: ACTIVE_COMPARATOR; Interventions: Drug: Dexamethasone | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Dexamethasone; Assigned to Arm(s): Dexamethasone | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: Telmisartan/nifedipine; Type: EXPERIMENTAL; Interventions: Drug: Telmisartan, Drug: Nifedipine | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo | Intervention Type: DRUG; Name: Telmisartan; Assigned to Arm(s): Telmisartan/nifedipine | Intervention Type: DRUG; Name: Nifedipine; Assigned to Arm(s): Telmisartan/nifedipine | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Placebo
D: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: Aminophylline; Type: ACTIVE_COMPARATOR; Interventions: Drug: Aminophylline | Arm Label: Methazolamide; Type: ACTIVE_COMPARATOR; Interventions: Drug: Methazolamide | Arm Label: Aminophylline+Methazolamide; Type: ACTIVE_COMPARATOR; Interventions: Drug: Aminophylline+Methazolamide | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo | Intervention Type: DRUG; Name: Aminophylline; Assigned to Arm(s): Aminophylline | Intervention Type: DRUG; Name: Methazolamide; Assigned to Arm(s): Methazolamide | Intervention Type: DRUG; Name: Aminophylline+Methazolamide; Assigned to Arm(s): Aminophylline+Methazolamide

Answer: A
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Effectiveness of Noradrenaline to Control Intraoperative Arterial Pressure in High-risk Surgical Patients: A Multicentre Prospective Randomized Controlled Trial
Brief Summary: The purpose of this study is to evaluate whether a preventive strategy of intraoperative arterial hypotension using noradrenaline can reduce the incidence of postoperative organ failure.


Options:
A: Arm Label: Noradrenaline; Type: EXPERIMENTAL; Interventions: Other: noradrenaline | Arm Label: Ephedrine chorhydrate; Type: EXPERIMENTAL; Interventions: Other: Ephedryne chorydrate | Intervention Type: OTHER; Name: noradrenaline; Assigned to Arm(s): Noradrenaline | Intervention Type: OTHER; Name: Ephedryne chorydrate; Assigned to Arm(s): Ephedrine chorhydrate
B: Arm Label: Increased bloodpressure during CPB; Type: EXPERIMENTAL; Interventions: Procedure: Increased bloodpressure during CPB. | Arm Label: Regular bloodpressure during CPB; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: PROCEDURE; Name: Increased bloodpressure during CPB.; Assigned to Arm(s): Increased bloodpressure during CPB
C: Arm Label: 1; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebos | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Drug: hydrocortisone and fludrocortisone and placebo | Arm Label: 3; Type: ACTIVE_COMPARATOR; Interventions: Drug: recombinant human activated protein C and placebos | Arm Label: 4; Type: ACTIVE_COMPARATOR; Interventions: Drug: recombinant human activated protein C and hydrocortisone and fludrocortisone | Intervention Type: DRUG; Name: placebos; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: hydrocortisone and fludrocortisone and placebo; Assigned to Arm(s): 2 | Intervention Type: DRUG; Name: recombinant human activated protein C and placebos; Assigned to Arm(s): 3 | Intervention Type: DRUG; Name: recombinant human activated protein C and hydrocortisone and fludrocortisone; Assigned to Arm(s): 4
D: Arm Label: 1; Type: N/A; Interventions: N/A | Arm Label: 2; Type: N/A; Interventions: N/A

Answer: A
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Attachment Based Family Therapy (ABFT) for Suicidal Adolescents
Brief Summary: This study will evaluate the efficacy of attachment based family therapy (ABFT) for treatment of suicidality in adolescents. The study will compare 16 weeks of treatment with ABFT to a control condition Family Enhanced Non-directive Supportive Therapy (FE-NST).


Options:
A: Arm Label: Zolpidem-CR; Type: ACTIVE_COMPARATOR; Interventions: Drug: Zolpidem-CR | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Zolpidem-CR; Assigned to Arm(s): Zolpidem-CR | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
B: Arm Label: Family-Enhanced Non-directive Supportive Therapy; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Family-Enhanced Non-directive Supportive Therapy | Arm Label: Attachment-Based Family Therapy; Type: EXPERIMENTAL; Interventions: Behavioral: Attachment-Based Family Therapy | Intervention Type: BEHAVIORAL; Name: Attachment-Based Family Therapy; Assigned to Arm(s): Attachment-Based Family Therapy | Intervention Type: BEHAVIORAL; Name: Family-Enhanced Non-directive Supportive Therapy; Assigned to Arm(s): Family-Enhanced Non-directive Supportive Therapy
C: Arm Label: therapy; Type: EXPERIMENTAL; Interventions: Behavioral: Cognitive behavioural therapy | Arm Label: Standard treatment; Type: ACTIVE_COMPARATOR; Interventions: Other: Standard treatment | Intervention Type: BEHAVIORAL; Name: Cognitive behavioural therapy; Assigned to Arm(s): therapy | Intervention Type: OTHER; Name: Standard treatment; Assigned to Arm(s): Standard treatment
D: Arm Label: Cognitive Therapy; Type: OTHER; Interventions: Behavioral: Cognitive Therapy | Arm Label: Enriched Care; Type: OTHER; Interventions: Other: Enriched Care | Intervention Type: BEHAVIORAL; Name: Cognitive Therapy; Assigned to Arm(s): Cognitive Therapy | Intervention Type: OTHER; Name: Enriched Care; Assigned to Arm(s): Enriched Care

Answer: B
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Attachment Based Family Therapy (ABFT) for Suicidal Adolescents
Brief Summary: This study will evaluate the efficacy of attachment based family therapy (ABFT) for treatment of suicidality in adolescents. The study will compare 16 weeks of treatment with ABFT to a control condition Family Enhanced Non-directive Supportive Therapy (FE-NST).


Options:
A: Arm Label: Study participants; Type: EXPERIMENTAL; Interventions: Other: EMA | Intervention Type: OTHER; Name: EMA; Assigned to Arm(s): Study participants
B: Arm Label: Family-Enhanced Non-directive Supportive Therapy; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Family-Enhanced Non-directive Supportive Therapy | Arm Label: Attachment-Based Family Therapy; Type: EXPERIMENTAL; Interventions: Behavioral: Attachment-Based Family Therapy | Intervention Type: BEHAVIORAL; Name: Attachment-Based Family Therapy; Assigned to Arm(s): Attachment-Based Family Therapy | Intervention Type: BEHAVIORAL; Name: Family-Enhanced Non-directive Supportive Therapy; Assigned to Arm(s): Family-Enhanced Non-directive Supportive Therapy
C: Arm Label: Intervention (2Share) + treatment as usual; Type: EXPERIMENTAL; Interventions: Behavioral: 2Share | Arm Label: Treatment as usual; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: BEHAVIORAL; Name: 2Share; Assigned to Arm(s): Intervention (2Share) + treatment as usual
D: Arm Label: MBT therapy plus treatment as usual; Type: EXPERIMENTAL; Interventions: Other: Mentalization-Based Group Therapy for Adolescents | Arm Label: Treatment as usual alone; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: OTHER; Name: Mentalization-Based Group Therapy for Adolescents; Assigned to Arm(s): MBT therapy plus treatment as usual

Answer: B
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomized Double-blind Trial of Two Parallel Groups Design to Evaluate the Efficacy of Smoking Cessation With Combined (Varenicline Plus Nicotine Patches) Versus Monotherapy (Varenicline Plus Placebo Patches)
Brief Summary: The purpose of this study is to assess the efficacy of smoking cessation by using varenicline as monotherapy (VRN + placebo patches) or combined therapy (VRN + nicotine patches).


Options:
A: Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo | Arm Label: varenicline; Type: EXPERIMENTAL; Interventions: Drug: Varenicline | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): placebo | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): varenicline
B: Intervention Type: DRUG; Name: varenicline; Assigned to Arm(s): N/A
C: Arm Label: Varenicline & nicotine patches; Type: EXPERIMENTAL; Interventions: Drug: Varenicline, Drug: Nicotine patches | Arm Label: Varenicline & placebo patches; Type: PLACEBO_COMPARATOR; Interventions: Drug: Varenicline, Drug: Placebo (nicotine patches) | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): Varenicline & nicotine patches, Varenicline & placebo patches | Intervention Type: DRUG; Name: Nicotine patches; Assigned to Arm(s): Varenicline & nicotine patches | Intervention Type: DRUG; Name: Placebo (nicotine patches); Assigned to Arm(s): Varenicline & placebo patches
D: Arm Label: Active; Type: EXPERIMENTAL; Interventions: Drug: Varenicline Tartrate | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Varenicline Tartrate; Assigned to Arm(s): Active | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo

Answer: C
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomized Double-blind Trial of Two Parallel Groups Design to Evaluate the Efficacy of Smoking Cessation With Combined (Varenicline Plus Nicotine Patches) Versus Monotherapy (Varenicline Plus Placebo Patches)
Brief Summary: The purpose of this study is to assess the efficacy of smoking cessation by using varenicline as monotherapy (VRN + placebo patches) or combined therapy (VRN + nicotine patches).


Options:
A: Arm Label: Varenicline & nicotine patches; Type: EXPERIMENTAL; Interventions: Drug: Varenicline, Drug: Nicotine patches | Arm Label: Varenicline & placebo patches; Type: PLACEBO_COMPARATOR; Interventions: Drug: Varenicline, Drug: Placebo (nicotine patches) | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): Varenicline & nicotine patches, Varenicline & placebo patches | Intervention Type: DRUG; Name: Nicotine patches; Assigned to Arm(s): Varenicline & nicotine patches | Intervention Type: DRUG; Name: Placebo (nicotine patches); Assigned to Arm(s): Varenicline & placebo patches
B: Arm Label: Varenicline; Type: EXPERIMENTAL; Interventions: Drug: Varenicline | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): Varenicline | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: Extended Varenicline Pretreatment; Type: EXPERIMENTAL; Interventions: Drug: Extended Varenicline Pretreatment | Arm Label: Short-term Varenicline Pretreatment; Type: EXPERIMENTAL; Interventions: Drug: Short-term Varenicline Pretreatment | Intervention Type: DRUG; Name: Extended Varenicline Pretreatment; Assigned to Arm(s): Extended Varenicline Pretreatment | Intervention Type: DRUG; Name: Short-term Varenicline Pretreatment; Assigned to Arm(s): Short-term Varenicline Pretreatment
D: Arm Label: varenicline and buproprion SR; Type: ACTIVE_COMPARATOR; Interventions: Drug: Varenicline, Drug: bupropion SR | Arm Label: varenicline and placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Varenicline, Drug: placebo | Intervention Type: DRUG; Name: Varenicline; Assigned to Arm(s): varenicline and buproprion SR, varenicline and placebo | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): varenicline and placebo | Intervention Type: DRUG; Name: bupropion SR; Assigned to Arm(s): varenicline and buproprion SR

Answer: A