Please select the eligibility criteria that correspond to the clinical trial below.
Title: Evaluation of a Mobile Preconception Lifestyle Programme in Couples Undergoing in Vitro Fertilisation: a Multicentre Randomized Controlled Trial (PreLiFe-RCT)
Brief Summary: The aim of the PreLiFe RCT is to assess the effects of a new mobile preconception lifestyle programme (PreLiFE-programme) for couples undergoing IVF. Couples about to start IVF will be randomized between an attention control programme or the PreLiFe-programme for 12 months or until an ongoing pregnancy is confirmed by ultrasound.This study will examine whether the PreLiFe-programme results in a higher cumulative ongoing pregnancy rate within 12 months as compared to an attention control programme. Secondary outcomes include changes in diet, physical activity, personal wellbeing, body mass index, waist circumference, quality of life and other reproductive outcomes including clinical pregnancy and time to pregnancy. Additionally, the partners' support and the feasibility of the PreLiFe-programme will be evaluated.


Options:
A: Inclusion criteria

* Indication for IVF/ICSI for the couple
* Woman's age \>18\< 38 years at randomization
* First, second or third IVF/ICSI treatment
* BMI \> or = 30.0 \<35.0 kg/m2
* Willing to participate and to sign informed consent

Exclusion Criteria:

* Diabetes mellitus treated with insulin
* Oocyte or sperm donation planned
* Preimplantation genetic diagnosis (PGD) treatment planned
* Azoospermia known at randomization
* Patient not having adequate knowledge of Swedish (to understand patient information and questionnaires)
* QEWP-R questionnaire indicating binge eating disorder for the woman
* Previous participation in the study
B: Inclusion Criteria:

* Infertile heterosexual couples about to start a first IVF-cycle (with or without ICSI) with infertility defined as the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse
* Women of couples aged ≤ 38 years
* Both partners possess a smartphone
* Both partners understand and speak Dutch
* Written informed consent after been informed on all aspects of the study

Exclusion Criteria:

* Couples with previous IVF/ICSI treatment cycles
* Couples where one of the partners has special dietary requirements including but not limited to patients that underwent bariatric surgery, patients with coeliac disease or renal disease
* Couples where one of the partners has specific movement's constraints including but not limited to patients with cerebral palsy or hemiparesis
* Couples starting IVF/ICSI with preimplantation genetic diagnosis (PGD)
* Couples using donor gametes or donor embryos
C: Inclusion Criteria:

* Women with a pregnancy wish within 1 year;
* Aged 18-40 years;
* Overweight/obesity (BMI ≥ 25 kg/m2).

Exclusion Criteria:

* Haemodynamically significant heart disease;
* Restrictive lung disease;
* Congenital metabolic disease;
* Mentally retarded;
* Bariatric surgery;
* Diabetes type II, dependent on medicine.
D: Inclusion Criteria:

* Couple attending a visit in an ART reproductive center (1st care regardless of the center regardless of the number of attempts in the center or in another center)
* Heterosexual infertile couple (absence of pregnancy after 12 months of unprotected intercourse)
* Men aged from 18 to 45 and women aged from 18 to 38
* Couple having not shown any opposition to the use of their data (observational study) and given their informed written consent to collect their biological samples
* Couple with good understanding of the French language
* Couple with computer equipment including webcam and internet access at home
* Affiliation to the French health insurance organism
* No-cons to the practice of adapted physical activity (non stabilized disease: diabetes, anemia, aplastic anemia, severe malnutrition, severe osteoporosis, heart or lung disease)
* Signing of the informed consent form

Exclusion Criteria:

* BMI upper 40 for one or both members of the couple
* Viral infection for one or both members of the couple (infection with HIV, Hepatitis B or C)
* Ongoing pregnancy
* One or both member of the couple medically treated for diabetes mellitus
* One or both member of the couple medically treated for a psychotic disorder
* Inability to comply with care program"
* Couple already enroll in the study

Answer: B