Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Oxygen Therapy During Acute Respiratory Failure in Immuno-compromised Patients
Brief Summary: In immunocompromised patients, Acute Respiratory Failure (ARF) is associated with a high case-fatality, particularly when invasive Mechanical Ventilation (MV) is required. In the most hypoxemic patients, oxygen administration through High Flow Nasal Cannula (HFNC) has been reported as an alternative to the venturi mask. The aim of this study is to compare HFNC and venturi mask on early respiratory deterioration and patient's comfort in that setting. The investigators planned a prospective randomized study in 4 Intensive Care Units (ICUs). As respiratory deterioration occurs early after ICU admission, patients are randomized to receive two hours of oxygen therapy either through HFNC or venturi mask. The primary endpoint is defined as the need for invasive or noninvasive MV in the 2-hour period. Secondary endpoints include comfort, dyspnea and thirst.


Options:
A: Arm Label: Venturi group; Type: ACTIVE_COMPARATOR; Interventions: Device: Venturi mask, Drug: Oxygen | Arm Label: HFNC group; Type: EXPERIMENTAL; Interventions: Device: High Flow Nasal Canula (HFNC), Drug: Oxygen | Intervention Type: DEVICE; Name: High Flow Nasal Canula (HFNC); Assigned to Arm(s): HFNC group | Intervention Type: DEVICE; Name: Venturi mask; Assigned to Arm(s): Venturi group | Intervention Type: DRUG; Name: Oxygen; Assigned to Arm(s): HFNC group, Venturi group
B: Arm Label: High Flow Conditioned Oxygen Therapy; Type: EXPERIMENTAL; Interventions: Device: Optiflow (Fisher&Paykel) | Arm Label: Standard Oxygen Therapy; Type: ACTIVE_COMPARATOR; Interventions: Device: Nasal cannulae or controlled oxygen concentration mask | Intervention Type: DEVICE; Name: Optiflow (Fisher&Paykel); Assigned to Arm(s): High Flow Conditioned Oxygen Therapy | Intervention Type: DEVICE; Name: Nasal cannulae or controlled oxygen concentration mask; Assigned to Arm(s): Standard Oxygen Therapy
C: Arm Label: O2 conventional : standard low flow therapy; Type: ACTIVE_COMPARATOR; Interventions: Other: O2 conventional | Arm Label: O2-HNF : high flow nasal oxygen therapy; Type: EXPERIMENTAL; Interventions: Device: O2-HFN : high flow nasal oxygen therapy | Arm Label: O2-HFN/NPPV; Type: EXPERIMENTAL; Interventions: Device: O2-HFN/NPPV : association of high flow nasal oxygen therapy and non invasive positive pressure ventilation | Intervention Type: OTHER; Name: O2 conventional; Assigned to Arm(s): O2 conventional : standard low flow therapy | Intervention Type: DEVICE; Name: O2-HFN : high flow nasal oxygen therapy; Assigned to Arm(s): O2-HNF : high flow nasal oxygen therapy | Intervention Type: DEVICE; Name: O2-HFN/NPPV : association of high flow nasal oxygen therapy and non invasive positive pressure ventilation; Assigned to Arm(s): O2-HFN/NPPV
D: Arm Label: BIPAP; Type: ACTIVE_COMPARATOR; Interventions: Device: Non invasive ventilation (VNI) | Arm Label: OPTIFLOW; Type: EXPERIMENTAL; Interventions: Device: Non invasive ventilation | Intervention Type: DEVICE; Name: Non invasive ventilation (VNI); Assigned to Arm(s): BIPAP | Intervention Type: DEVICE; Name: Non invasive ventilation; Assigned to Arm(s): OPTIFLOW

Answer: A