Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Effect of a Polyphenol Rich Diet on Vascular and Platelet Function- a Randomised Control Trial
Brief Summary: Previous work has shown that increasing fruit and vegetable intake in patients with high blood pressure improves cardiovascular function. Research indicates that this may be partly owing to compounds called polyphenols, which are found in abundance in fruits and vegetables and other foods such as wine, tea and dark chocolate. The investigators now wish to test if consuming fruits and vegetables (including berries which are very rich in polyphenols), as well as dark chocolate, has further benefits for cardiovascular function. A total of 110 subjects with high blood pressure will be recruited and asked to follow a low polyphenol diet (2 portions of fruit and vegetables daily and no berries or dark chocolate) for four weeks (a washout period). They will then be randomised to continue this diet or to consume 6 portions of fruits and vegetables (to include 1 portion berries) and 1 portion of dark chocolate daily for 8 weeks. The fruit, vegetables and dark chocolate will be provided free of charge and delivered to the homes of the participants who are randomised to the high fruit and vegetable arm of the study.

Assessment of microvascular and platelet function will be undertaken before and after consuming this diet. Improvements in these tests of cardiovascular function have previously been linked to reduced risks of heart disease in people with high blood pressure. This study will provide evidence as to whether or not a polyphenol rich diet can reduce the risk of developing heart disease.


Options:
A: Arm Label: Intervention A; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Flavonoid enrichment (cocoa / soy compounds) | Arm Label: Intervention B; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Flavonoid enrichment (cocoa / soy compounds) | Intervention Type: DIETARY_SUPPLEMENT; Name: Flavonoid enrichment (cocoa / soy compounds); Assigned to Arm(s): Intervention A | Intervention Type: DIETARY_SUPPLEMENT; Name: Flavonoid enrichment (cocoa / soy compounds); Assigned to Arm(s): Intervention B
B: Arm Label: Control; Type: ACTIVE_COMPARATOR; Interventions: Other: Control breakfast, Other: High glycemic index breakfast, Other: Low glycemic index breakfast | Arm Label: Intervention 1; Type: EXPERIMENTAL; Interventions: Other: Control breakfast, Other: High glycemic index breakfast, Other: Low glycemic index breakfast | Arm Label: Intervention 2; Type: EXPERIMENTAL; Interventions: Other: Control breakfast, Other: High glycemic index breakfast, Other: Low glycemic index breakfast | Intervention Type: OTHER; Name: Control breakfast; Assigned to Arm(s): Control, Intervention 1, Intervention 2 | Intervention Type: OTHER; Name: High glycemic index breakfast; Assigned to Arm(s): Control, Intervention 1, Intervention 2 | Intervention Type: OTHER; Name: Low glycemic index breakfast; Assigned to Arm(s): Control, Intervention 1, Intervention 2
C: Arm Label: Low- polyphenol diet; Type: OTHER; Interventions: Other: Two portions of fruit and vegetables per day (excluding berries and dark chocolate) | Arm Label: High-polyphenol diet; Type: ACTIVE_COMPARATOR; Interventions: Other: Six portions of fruit and vegetables per day (one of which must be berries) and 50g dark chocolate. | Intervention Type: OTHER; Name: Two portions of fruit and vegetables per day (excluding berries and dark chocolate); Assigned to Arm(s): Low- polyphenol diet | Intervention Type: OTHER; Name: Six portions of fruit and vegetables per day (one of which must be berries) and 50g dark chocolate.; Assigned to Arm(s): High-polyphenol diet
D: Arm Label: flavanol rich intervention; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Flavanol (410 mg) | Arm Label: flavanol free intervention; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Control (no flavanols) | Intervention Type: DIETARY_SUPPLEMENT; Name: Flavanol (410 mg); Assigned to Arm(s): flavanol rich intervention | Intervention Type: DIETARY_SUPPLEMENT; Name: Control (no flavanols); Assigned to Arm(s): flavanol free intervention

Answer: C