Please select the eligibility criteria that correspond to the clinical trial below.
Title: Correction of Myopia Evaluation Trial 2 (COMET2): A Randomized Trial of the Effect of Progressive Addition Lenses Versus Single Vision Lenses on Low Myopia Associated With Large Accommodative Lags and Near Esophoria in Children
Brief Summary: The purpose of the study is to determine if progressive addition lenses (PALs) versus single vision lenses (SVLs) slow the progression of low myopia in children with poor accommodative responses (i.e., large accommodative lags) and near esophoria.


Options:
A: Inclusion Criteria:

* Myopia (refractive sphere): \> 5.75D
* Astigmatism: \< ½ of myopia; with-the-rule astigmatism (axes 180 +/- 30) ≤1.25D; astigmatism of other axes ≤ 0.50D
* Spherical equivalent (SE): \> 5.75D
* Anisometropia: ≤ 1.50D in both refractive sphere, refractive cylinder and SE
* Best corrected monocular visual acuity: equal to or better than 0.10 in logMAR scale in both eyes
* Willingness for randomization
* Availability for follow-up for at least 2 years

Exclusion Criteria:

* Strabismus at distance or near
* Contraindication for contact lens wear and orthokeratology (e.g. limbus to limbus corneal cylinder and dislocated corneal apex
* Systemic or ocular conditions which may affect contact lens wear (e.g. allergy and medication)
* Systemic or ocular conditions which may affect refractive development (e.g. Down syndrome, ptosis)
B: Inclusion Criteria:

* Be between 8 and 12 years of age inclusive.
* Best-corrected visual acuity by manifest refraction of +0.10 logMAR.
* Spherical Equivalent Refractive Error between -0.75 and -4.00 D
* inclusive astigmatism: \< -0.75 D and anisometropia: \< 1.00 D
* Possess wearable and visually functional eyeglasses.
* Agree to wear the assigned contact lenses for a minimum of 10 hours per day, - at least 6 days per week, for the duration of the 3 year study.

Exclusion Criteria:

* Subject has previously or currently wears contact lenses or rigid gas permeable contact lenses, including orthokeratology lenses.
* Subject is currently or within 30 days prior to this study has been an active participant in another clinical study.
* Current or prior use of bifocals, progressive addition lenses, atropine, pirenzepine or ANY other myopia control treatment.
* Regular use of ocular medications (prescription or over-the-counter), artificial tears, or wetting agents.
* Current use of systemic medications which may significantly affect contact lens wear, tear film production, pupil size, accommodation or refractive state.
* A known allergy to fluorescein, benoxinate, proparacaine or tropicamide.
* Strabismus by cover test at far (4 m) or near (40 cm) wearing distance correction.
* Any ocular, systemic or neuro-developmental conditions that could influence refractive development.
C: Inclusion Criteria:

* Myopia between -0.50 and -6.00
* Eso fixation disparity at 33cm with distance correction
* Astigmatism 1.00 or less
* Ability to wear soft contact lenses

Exclusion Criteria:

* Presence of ocular disease preventing wear of contacts
* Pregnancy or nursing
* Use of certain medications
D: Inclusion Criteria:

* Refractive error determined by cycloplegic autorefraction which meets all of the following:

  1. Spherical equivalent: -0.50 to -3.00 D in both eyes
  2. Astigmatism \<= 1.5 D in both eyes
  3. Anisometropia \<= 1.00 D difference between eyes in spherical equivalent
* Visual acuity is at least 20/20 with best subjective refraction in both eyes
* Accommodative response at near (33 cm) is less than 2.0D by non-cycloplegic autorefraction
* Near esophoria (\>= 2.0 PD) present by alternate prism and cover test (APCT) at near using best refractive correction determined from non-cycloplegic subjective refraction

Exclusion Criteria:

* Strabismus present by cover-uncover test at far, near, and/or near with +2.00D over best subjective refraction
* Current or prior use of PALs, bifocals, or contact lenses in either eye (prior or current use of SVLs is allowed)

Answer: D