Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Efficacy, Safety and Immunogenicity Study of GSK Biologicals' Herpes Zoster Vaccine GSK1437173A in Adults Aged 70 Years or Older
Brief Summary: The purpose of this observer-blind study is to evaluate the efficacy, safety and immunogenicity of GSK Biologicals' candidate Herpes Zoster (HZ) vaccine in adults aged ≥ 70 years.

Two studies (Zoster-006 \[NCT01165177\] and Zoster-022 \[NCT01165229\]) will be conducted concurrently to evaluate efficacy of GSK1437173A vaccine. A pooled analysis of data from both studies combined will be conducted contingent on each study achieving its objectives. This protocol posting also deals with the outcome measures related to the pooled analysis.


Options:
A: Arm Label: A - Live zoster vaccine; Type: ACTIVE_COMPARATOR; Interventions: Biological: Zostavax, Biological: Placebo | Arm Label: B - recombinant zoster vaccine; Type: ACTIVE_COMPARATOR; Interventions: Biological: HZ/su vaccine | Arm Label: C - Live zoster vaccine; Type: ACTIVE_COMPARATOR; Interventions: Biological: Zostavax, Biological: Placebo | Arm Label: D - recombinant zoster vaccine; Type: ACTIVE_COMPARATOR; Interventions: Biological: HZ/su vaccine | Intervention Type: BIOLOGICAL; Name: Zostavax; Assigned to Arm(s): A - Live zoster vaccine, C - Live zoster vaccine | Intervention Type: BIOLOGICAL; Name: HZ/su vaccine; Assigned to Arm(s): B - recombinant zoster vaccine, D - recombinant zoster vaccine | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): A - Live zoster vaccine, C - Live zoster vaccine
B: Arm Label: GSK1437173A _LD Group; Type: EXPERIMENTAL; Interventions: Biological: Herpes Zoster vaccine GSK1437173A Low Dose | Arm Label: GSK1437173A _MD Group; Type: EXPERIMENTAL; Interventions: Biological: Herpes Zoster vaccine GSK1437173A Medium Dose | Arm Label: GSK1437173A _HD Group; Type: EXPERIMENTAL; Interventions: Biological: Herpes Zoster vaccine GSK1437173A High Dose | Arm Label: Placebo + GSK1437173A _HD Group; Type: PLACEBO_COMPARATOR; Interventions: Biological: Herpes Zoster vaccine GSK1437173A High Dose, Biological: Placebo | Arm Label: GSK1437173A_MODIFIED GROUP; Type: ACTIVE_COMPARATOR; Interventions: Biological: Herpes Zoster vaccine GSK1437173A Modified | Intervention Type: BIOLOGICAL; Name: Herpes Zoster vaccine GSK1437173A Low Dose; Assigned to Arm(s): GSK1437173A _LD Group | Intervention Type: BIOLOGICAL; Name: Herpes Zoster vaccine GSK1437173A Medium Dose; Assigned to Arm(s): GSK1437173A _MD Group | Intervention Type: BIOLOGICAL; Name: Herpes Zoster vaccine GSK1437173A High Dose; Assigned to Arm(s): GSK1437173A _HD Group, Placebo + GSK1437173A _HD Group | Intervention Type: BIOLOGICAL; Name: Herpes Zoster vaccine GSK1437173A Modified; Assigned to Arm(s): GSK1437173A_MODIFIED GROUP | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Placebo + GSK1437173A _HD Group
C: Arm Label: Co-Ad Group; Type: EXPERIMENTAL; Interventions: Biological: Herpes Zoster vaccine GSK 1437173A, Biological: Licensed pneumococcal polysaccharide conjugate vaccine (23-valent, adsorbed), Pneumovax 23™ | Arm Label: Control Group; Type: ACTIVE_COMPARATOR; Interventions: Biological: Herpes Zoster vaccine GSK 1437173A, Biological: Licensed pneumococcal polysaccharide conjugate vaccine (23-valent, adsorbed), Pneumovax 23™ | Intervention Type: BIOLOGICAL; Name: Herpes Zoster vaccine GSK 1437173A; Assigned to Arm(s): Co-Ad Group, Control Group | Intervention Type: BIOLOGICAL; Name: Licensed pneumococcal polysaccharide conjugate vaccine (23-valent, adsorbed), Pneumovax 23™; Assigned to Arm(s): Co-Ad Group, Control Group
D: Arm Label: Zoster vaccine group; Type: EXPERIMENTAL; Interventions: Biological: Herpes Zoster Vaccine GSK1437173A | Arm Label: Placebo group; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Intervention Type: BIOLOGICAL; Name: Herpes Zoster Vaccine GSK1437173A; Assigned to Arm(s): Zoster vaccine group | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Placebo group

Answer: D