Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Prospective, Randomized, Multi-Center Trial of Initial Trophic Enteral Feeding Followed by Advancement to Full-Calorie Enteral Feeding vs. Early Advancement to Full-Calorie Enteral Feeding in Patients With Acute Lung Injury (ALI) or Acute Respiratory Distress Syndrome (ARDS) and Prospective, Randomized, Blinded, Placebo-Controlled, Multi-Center Trial of Omega-3 Fatty Acid, Gamma-Linolenic Acid, and Anti-Oxidant Supplementation in the Management of Acute Lung Injury (ALI) or Acute Respiratory Distress Syndrome (ARDS)
Brief Summary: Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are medical conditions that occur when there is severe inflammation and increased fluids in both lungs, making it difficult for the lungs to function properly. Hospital treatment for a person with ALI/ARDS often includes the use of a breathing machine, or ventilator, until the person is able to breathe without assistance. Initiating proper nutrition through a feeding tube early in a person's hospital stay may help to improve recovery, but the optimal timing, composition, and amount of feeding treatments are unknown. This study will evaluate whether early or delayed full-calorie feeding through a feeding tube is more effective in reducing recovery time and increasing survival rates in people with ALI/ARDS. The study will also determine whether supplementing the feedings with omega-3 fatty acids and antioxidants benefits people with ALI/ARDS.


Options:
A: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Behavioral: Minimal (Trophic) Feeding | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Behavioral: Full Feeding | Intervention Type: BEHAVIORAL; Name: Minimal (Trophic) Feeding; Assigned to Arm(s): 1 | Intervention Type: BEHAVIORAL; Name: Full Feeding; Assigned to Arm(s): 2
B: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Behavioral: Minimal (Trophic) Feeding, Dietary Supplement: Omega-3 Fatty Acids and Antioxidant Supplements | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Behavioral: Full Feeding, Dietary Supplement: Omega-3 Fatty Acids and Antioxidant Supplements | Arm Label: 3; Type: EXPERIMENTAL; Interventions: Behavioral: Minimal (Trophic) Feeding, Dietary Supplement: Placebo | Arm Label: 4; Type: PLACEBO_COMPARATOR; Interventions: Behavioral: Full Feeding, Dietary Supplement: Placebo | Intervention Type: BEHAVIORAL; Name: Minimal (Trophic) Feeding; Assigned to Arm(s): 1, 3 | Intervention Type: BEHAVIORAL; Name: Full Feeding; Assigned to Arm(s): 2, 4 | Intervention Type: DIETARY_SUPPLEMENT; Name: Omega-3 Fatty Acids and Antioxidant Supplements; Assigned to Arm(s): 1, 2 | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo; Assigned to Arm(s): 3, 4
C: Arm Label: Full enteral feeding; Type: ACTIVE_COMPARATOR; Interventions: Other: Initial enteral feeding | Arm Label: Modified full enteral feeding; Type: EXPERIMENTAL; Interventions: Other: Initial enteral feeding, Drug: metoclopramide or mosapride | Arm Label: Permissive underfeeding; Type: EXPERIMENTAL; Interventions: Other: Initial enteral feeding | Intervention Type: OTHER; Name: Initial enteral feeding; Assigned to Arm(s): Full enteral feeding, Modified full enteral feeding, Permissive underfeeding | Intervention Type: DRUG; Name: metoclopramide or mosapride; Assigned to Arm(s): Modified full enteral feeding
D: Arm Label: TARGET protocol EN 1.5 kcal/mL; Type: EXPERIMENTAL; Interventions: Dietary Supplement: TARGET protocol EN 1.5 kcal/mL | Arm Label: TARGET protocol EN 1.0 kcal/mL; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: TARGET protocol EN 1.0 kcal/mL | Intervention Type: DIETARY_SUPPLEMENT; Name: TARGET protocol EN 1.5 kcal/mL; Assigned to Arm(s): TARGET protocol EN 1.5 kcal/mL | Intervention Type: DIETARY_SUPPLEMENT; Name: TARGET protocol EN 1.0 kcal/mL; Assigned to Arm(s): TARGET protocol EN 1.0 kcal/mL

Answer: B