Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Phase III Trial Comparing Docetaxel Every Third Week to Biweekly Docetaxel Monotherapy in Metastatic Hormone Refractory Prostate Cancer Patients - PROSTY Trial
Brief Summary: RATIONALE: Drugs used in chemotherapy, such as docetaxel and prednisone, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known which schedule of docetaxel and prednisone is more effective in treating prostate cancer.

PURPOSE: This randomized phase III trial is studying two different schedules of docetaxel and prednisone to compare how well they work in treating patients with metastatic prostate cancer.


Options:
A: Arm Label: Abiraterone acetate + Prednisone + ADT; Type: EXPERIMENTAL; Interventions: Drug: Abiraterone acetate, Drug: Prednisone, Other: Androgen deprivation therapy (ADT) | Arm Label: Placebo + Androgen Deprivation Therapy (ADT); Type: PLACEBO_COMPARATOR; Interventions: Other: Androgen deprivation therapy (ADT), Drug: Abiraterone acetate Placebo, Drug: Prednisone Placebo | Intervention Type: DRUG; Name: Abiraterone acetate; Assigned to Arm(s): Abiraterone acetate + Prednisone + ADT | Intervention Type: DRUG; Name: Prednisone; Assigned to Arm(s): Abiraterone acetate + Prednisone + ADT | Intervention Type: OTHER; Name: Androgen deprivation therapy (ADT); Assigned to Arm(s): Abiraterone acetate + Prednisone + ADT, Placebo + Androgen Deprivation Therapy (ADT) | Intervention Type: DRUG; Name: Abiraterone acetate Placebo; Assigned to Arm(s): Placebo + Androgen Deprivation Therapy (ADT) | Intervention Type: DRUG; Name: Prednisone Placebo; Assigned to Arm(s): Placebo + Androgen Deprivation Therapy (ADT)
B: Arm Label: Arm I; Type: EXPERIMENTAL; Interventions: Drug: docetaxel, Drug: prednisone | Arm Label: Arm II; Type: EXPERIMENTAL; Interventions: Drug: docetaxel, Drug: prednisone | Intervention Type: DRUG; Name: docetaxel; Assigned to Arm(s): Arm I, Arm II | Intervention Type: DRUG; Name: prednisone; Assigned to Arm(s): Arm I, Arm II
C: Arm Label: Hormonotherapy + chemotherapy; Type: EXPERIMENTAL; Interventions: Drug: antiandrogen therapy, Drug: docetaxel, Drug: goserelin acetate, Procedure: orchiectomy | Arm Label: Hormonotherapy alone; Type: ACTIVE_COMPARATOR; Interventions: Drug: antiandrogen therapy, Drug: goserelin acetate, Procedure: orchiectomy | Intervention Type: DRUG; Name: antiandrogen therapy; Assigned to Arm(s): Hormonotherapy + chemotherapy, Hormonotherapy alone | Intervention Type: DRUG; Name: docetaxel; Assigned to Arm(s): Hormonotherapy + chemotherapy | Intervention Type: DRUG; Name: goserelin acetate; Assigned to Arm(s): Hormonotherapy + chemotherapy, Hormonotherapy alone | Intervention Type: PROCEDURE; Name: orchiectomy; Assigned to Arm(s): Hormonotherapy + chemotherapy, Hormonotherapy alone
D: Arm Label: Androgen-Deprivation Therapy and Docetaxel; Type: EXPERIMENTAL; Interventions: Drug: androgen-deprivation therapy, Drug: docetaxel | Arm Label: Androgen-Deprivation Therapy alone; Type: ACTIVE_COMPARATOR; Interventions: Drug: androgen-deprivation therapy | Intervention Type: DRUG; Name: androgen-deprivation therapy; Assigned to Arm(s): Androgen-Deprivation Therapy alone, Androgen-Deprivation Therapy and Docetaxel | Intervention Type: DRUG; Name: docetaxel; Assigned to Arm(s): Androgen-Deprivation Therapy and Docetaxel

Answer: B