Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Swiss PACK-CXL (Photoactivated Chromophore for Infectious Keratitis Cross-linking) Multicenter Trial for the Treatment of Infectious Keratitis
Brief Summary: To assess the safety and efficacy of PACK-CXL (photoactivated chromophore for infectious keratitis cross-linking) as a firstline treatment for infectious corneal infiltrates and early corneal ulcers, and compare it to the current standard of care, antimicrobial therapy.


Options:
A: Arm Label: Active Treatment Arm; Type: EXPERIMENTAL; Interventions: Drug: Riboflavin, Drug: Dextran, Device: UVA Light Source | Arm Label: Control Treatment Arm; Type: ACTIVE_COMPARATOR; Interventions: Drug: Riboflavin, Drug: Dextran | Intervention Type: DRUG; Name: Riboflavin; Assigned to Arm(s): Active Treatment Arm, Control Treatment Arm | Intervention Type: DRUG; Name: Dextran; Assigned to Arm(s): Active Treatment Arm, Control Treatment Arm | Intervention Type: DEVICE; Name: UVA Light Source; Assigned to Arm(s): Active Treatment Arm
B: Arm Label: antibiotic treatment alone; Type: ACTIVE_COMPARATOR; Interventions: Drug: antibiotic treatment | Arm Label: Crosslinking + Antibiotic; Type: EXPERIMENTAL; Interventions: Device: Crosslinking, Drug: antibiotic treatment | Intervention Type: DEVICE; Name: Crosslinking; Assigned to Arm(s): Crosslinking + Antibiotic | Intervention Type: DRUG; Name: antibiotic treatment; Assigned to Arm(s): Crosslinking + Antibiotic, antibiotic treatment alone
C: Arm Label: Treatment (PACK-CXL); Type: EXPERIMENTAL; Interventions: Device: PACK-CXL | Arm Label: Antimicrobial therapy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Cefazolin in combination with either tobramycin or gentamicin, Drug: Cycloplegic agents (cyclopentolate 1% eye drops), Drug: Fluoroquinolones (Besifloxacin ; ciprofloxacin ; gatifloxacin ; levofloxacin ; moxifloxacin ; ofloxacin ), Drug: Corticosteroids (prednisolone acetate 0.5% or 1% eye drops) | Intervention Type: DEVICE; Name: PACK-CXL; Assigned to Arm(s): Treatment (PACK-CXL) | Intervention Type: DRUG; Name: Cefazolin in combination with either tobramycin or gentamicin; Assigned to Arm(s): Antimicrobial therapy | Intervention Type: DRUG; Name: Cycloplegic agents (cyclopentolate 1% eye drops); Assigned to Arm(s): Antimicrobial therapy | Intervention Type: DRUG; Name: Fluoroquinolones (Besifloxacin ; ciprofloxacin ; gatifloxacin ; levofloxacin ; moxifloxacin ; ofloxacin ); Assigned to Arm(s): Antimicrobial therapy | Intervention Type: DRUG; Name: Corticosteroids (prednisolone acetate 0.5% or 1% eye drops); Assigned to Arm(s): Antimicrobial therapy
D: Arm Label: Collagen crosslinking group; Type: EXPERIMENTAL; Interventions: Procedure: collagen crosslinking group, Drug: Topical anti-fungal therapy | Arm Label: standard medical therapy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Topical anti-fungal therapy | Intervention Type: PROCEDURE; Name: collagen crosslinking group; Assigned to Arm(s): Collagen crosslinking group | Intervention Type: DRUG; Name: Topical anti-fungal therapy; Assigned to Arm(s): Collagen crosslinking group, standard medical therapy

Answer: C