Please select the eligibility criteria that correspond to the clinical trial below.
Title: Relapse Prevention Trial in Top End Aboriginal People With Chronic Mental Illness
Brief Summary: A new treatment for indigenous people with mental illness in remote communities has been developed. The study hypothesis is that this new treatment will result in better outcomes for clients and carers than the outcomes of clients and carers who do not receive the treatment. The treatment is a combination of a talking treatment and sharing of stories about mental health. The treatment will be delivered to the client with their chosen carer and with the local Aboriginal Mental Health Worker or Health Worker. The treatment will be given by the research team - a psychiatrist and an indigenous research officer. The trial will compare two groups of clients - a control group which is receiving 'treatment as usual', and the group which receives the new treatment. Measures of social functioning and symptoms of mental illness will be administered at base line and every six months for two years.


Options:
A: Inclusion Criteria:

* Cases and Controls must:

  * Be able to understand the study and provide written informed consent.
  * Be male or female 18 -35 years of age.
  * Be in generally good health
  * If female of childbearing potential, have a negative serum pregnancy test on study day

Cases must:

* Meet criteria for cannabis dependence as primary diagnosis as determined by the Substance Abuse module of SCID (Structured Clinical Interview for DSM-IV).
* Not currently seeking treatment for cannabis dependence.
* Have a positive urine drug test for cannabis on the study day
* Avoid alcohol and other recreational drug use (except cannabis and/or nicotine) for 48 h before testing.

Exclusion Criteria:

* Cases and Controls must not:

  * Be pregnant or lactating
  * Have implanted electrical medical device (e.g. pacemaker, vagal nerve stimulator)
  * Have non-secure metallic foreign bodies
  * Have met criteria for another axis 1 diagnosis in the past 6 months
  * Receive psychotropically active or vasoactive medications (within 6 weeks of screen day)
  * Have chronic medical illness
  * Have epilepsy
  * Have a history of head injury that required hospitalization
  * Have claustrophobia
  * Have orthopedic or other problems precluding them from performing exercise protocol
  * Have body mass index (BMI) less than 19 kg/m2
  * Weighing more than 275 pounds (MRI table limit)

Cases must not:

* Have current dependence, as determined by the SCID, on any psychoactive substance other than nicotine and/or cannabinoid
* Have any serious medical or psychiatric illnesses and/or clinically significant symptoms, which in the judgment of the PI or his/her designee would make them unsafe, or would make compliance with the study protocol difficult or put the study staff at undue risk
B: Inclusion Criteria:

* 18 years or older
* Moderate risk category on the ASSIST scores

Exclusion Criteria:

* planning to move out of New Mexico in the next year
* receipt of formal drug abuse treatment or a brief intervention for drug use in the past month.
C: Inclusion Criteria:

* motivation to change cannabis use
* age 16 or older
* current (12 mth) regular cannabis use (at least 2 days a week)
* informed consent to the study procedures and assessments

Exclusion Criteria:

* current alcohol or any illicit drug dependence syndrome according to DSM-IV other than due to cannabis
* lifetime history of any psychotic disorder
* current severe episode of Major depression
* current panic-agoraphobic disorder (severe)
* severe learning disability, brain damage or pervasive developmental disorder
* currently acute suicidality
* not fluent in german language
* any other current treatment for cannabis use disorders
D: Inclusion Criteria:

* Participants will be recruited by Aboriginal Mental Health Workers - or nominated by mental health staff or the General Practitioner. The treating doctors or local mental health team will be notified of the nomination in each case and, if they have no concerns, the Aboriginal Mental Health Worker will arrange the information and consent session with the research team. The participants will be clients who have a primary chronic mental illness, are aged over 18 years, are able to give informed consent, and are current clients. The diagnoses for inclusion are Schizophrenia, Delusional disorder, Schizoaffective disorder, Drug-induced psychosis, Non-specific psychoses, and Affective disorders. The criteria for chronicity for the purposes of the project are defined by two or more episodes of illness severe enough to require medical intervention and treatment. The carer will be identified by discussion between the client and the Aboriginal Mental Health Worker or Health Worker.

Exclusion Criteria:

People aged less than 18 years, and people with known Intellectual disability or organic brain disorders will be excluded. People with illnesses which have not recurred, or which are not likely to recur will be excluded.

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Answer: D