Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Does the Type of Drain Influence the Postoperative Pancreatic Fistula Rate After Pancreatic Resection?
Brief Summary: Pancreatic resection is the only potentially curative modality of treatment for pancreatic neoplasm. The mortality associated with this procedure decreased rapidly in the past decades. However, the morbidity associated with pancreatic resection remains high. The main reason for postoperative morbidity is postoperative pancreatic fistula (POPF), which is regarded as the most ominous complication following pancreatic resection. Its reported incidence varies in the surgical literature from 10% to \>30%.

Recently published studies showed that the placement of intraoperative drains, manipulation with the drains, timing of removal of the drain, and especially the type of drain, have significant effect on the postoperative complications, and especially POPF.

Controversy exists regarding the type of intraoperatively placed drain. Nowadays, the two most commonly used systems are closed suction drainage and closed gravity drainage. Open systems have been abandoned in most centers as they are obsolete.

Our hypothesis is that the closed suction drain will have better results as it is more effective than the gravity drainage. However, some surgeons claim that the suction system can actively suck the pancreatic juice through the anastomosis or suture and thus promote the development of POPF.

The aim of this study is to compare closed suction drains and closed gravity drains after pancreatic resection in a randomized controlled study.

The primary end-point is the postoperative pancreatic fistula rate. The secondary end-point is the postoperative morbidity.


Options:
A: Arm Label: SOM230; Type: EXPERIMENTAL; Interventions: Drug: Pasireotide (SOM230) | Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Other: placebo | Intervention Type: DRUG; Name: Pasireotide (SOM230); Assigned to Arm(s): SOM230 | Intervention Type: OTHER; Name: placebo; Assigned to Arm(s): placebo
B: Arm Label: Closed suction drain; Type: ACTIVE_COMPARATOR; Interventions: Procedure: closed suction drain | Arm Label: Closed gravity drain; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Closed gravity drain | Intervention Type: PROCEDURE; Name: Closed gravity drain; Assigned to Arm(s): Closed gravity drain | Intervention Type: PROCEDURE; Name: closed suction drain; Assigned to Arm(s): Closed suction drain
C: Arm Label: Early drain removal; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Postoperative drain removal | Arm Label: Standard drain removal; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Postoperative drain removal | Intervention Type: PROCEDURE; Name: Postoperative drain removal; Assigned to Arm(s): Early drain removal, Standard drain removal
D: Arm Label: No Drains; Type: EXPERIMENTAL; Interventions: Procedure: No Drains | Arm Label: Drains; Type: EXPERIMENTAL; Interventions: Procedure: Drains | Intervention Type: PROCEDURE; Name: No Drains; Assigned to Arm(s): No Drains | Intervention Type: PROCEDURE; Name: Drains; Assigned to Arm(s): Drains

Answer: B