Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Same Day Community-based ART Initiation Versus Clinic-based Pre-ART Assessment and Counselling for Individuals Newly Tested HIV-positive During Community-based HIV Testing in Rural Lesotho - a Randomized Controlled Trial
Brief Summary: The CASCADE-trial is a two-armed open-label randomized controlled trial conducted in rural Lesotho. Participants who were tested HIV-positive during community-based HIV testing and counseling campaigns are randomized to the intervention or control arm. Allocation is 1:1 with parallel assignment.

Participants in the control arm follow the standard of care after a community-based HIV test result: They are referred to the nearest clinic where they will receive baseline laboratory testing and adherence counseling. After at least 2 clinic visits for adherence counseling they can start anti-retroviral therapy (ART). After ART-initiation they have to attend monthly follow-up at the clinic for drug refill. Individuals randomized to the intervention arm are proposed same day community-based ART initiation combined with less frequent follow-up visits. The primary outcomes are linkage to care at 3 months and viral suppression at 12 months after having tested HIV-positive during the community-based HIV testing and counseling campaigns.


Options:
A: Arm Label: Standard group, non-pregnant adults; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Standard group, pregnant women; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Rapid group, non-pregnant adults; Type: EXPERIMENTAL; Interventions: Other: Rapid ART initiation | Arm Label: Rapid group, pregnant women; Type: EXPERIMENTAL; Interventions: Other: Rapid ART initiation | Intervention Type: OTHER; Name: Rapid ART initiation; Assigned to Arm(s): Rapid group, non-pregnant adults, Rapid group, pregnant women
B: Arm Label: Immediate ARV treatment initiation; Type: EXPERIMENTAL; Interventions: Drug: Immediate ARV treatment initiation with TDF/FTC/EFV | Arm Label: South African recommendation guided ARV initiation; Type: OTHER; Interventions: Other: South African recommendation guided ARV (TDF/FTC/EFV) initiation | Intervention Type: DRUG; Name: Immediate ARV treatment initiation with TDF/FTC/EFV; Assigned to Arm(s): Immediate ARV treatment initiation | Intervention Type: OTHER; Name: South African recommendation guided ARV (TDF/FTC/EFV) initiation; Assigned to Arm(s): South African recommendation guided ARV initiation
C: Arm Label: Immediate ART; Type: EXPERIMENTAL; Interventions: Other: Strategy: Immediate ART | Arm Label: Deferred ART; Type: ACTIVE_COMPARATOR; Interventions: Other: Strategy: Deferred ART | Intervention Type: OTHER; Name: Strategy: Immediate ART; Assigned to Arm(s): Immediate ART | Intervention Type: OTHER; Name: Strategy: Deferred ART; Assigned to Arm(s): Deferred ART
D: Arm Label: Standard of care; Type: ACTIVE_COMPARATOR; Interventions: Other: Standard of care | Arm Label: Same-day ART initiation with less frequent follow-up visits; Type: EXPERIMENTAL; Interventions: Other: Same-day ART initiation | Intervention Type: OTHER; Name: Same-day ART initiation; Assigned to Arm(s): Same-day ART initiation with less frequent follow-up visits | Intervention Type: OTHER; Name: Standard of care; Assigned to Arm(s): Standard of care

Answer: D