Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Treating PTSD in Patients With Borderline Personality Disorder
Brief Summary: Individuals with borderline personality disorder (BPD) are the quintessential multi-problem patients, often presenting to treatment with numerous dysfunctional behaviors and comorbid diagnoses. Dialectical Behavior Therapy (DBT) is a comprehensive, cognitive-behavioral treatment for BPD that has been shown effective in reducing the primary problems it is designed to treat; namely, the frequency and severity of self-injurious and suicidal behavior, maintenance in treatment, and severe problems in living. However, the DBT treatment manual does not currently include a protocol specifying when or how to treat posttraumatic stress disorder (PTSD), a comorbid diagnosis that is prevalent in BPD patients and may maintain or exacerbate BPD criterion behaviors. Similarly, many of the existing treatment outcome studies for PTSD have excluded suicidal, substance abusing, and multiply diagnosed patients, thereby making it difficult to determine the generalizability of these approaches to individuals with BPD. The research proposed here is focused on the development of a protocol based on Prolonged Exposure therapy to treat PTSD in BPD patients that can be integrated into standard DBT, as well as the initial evaluation of this protocol's feasibility, acceptability, and efficacy. The treatment development and pilot testing process will occur in two phases, including measure development and standardization of the treatment protocol via clinical pre-testing (Phase 1); and pilot and feasibility testing of the intervention via a randomized controlled trial (RCT) comparing standard DBT + PTSD Protocol to standard DBT Only (Phase 2). Information gathered during the pilot RCT will be used to inform the design and conduct of a subsequent full-scale RCT. This research has the potential to significantly expand and improve upon the most empirically supported treatment currently available for BPD, while also demonstrating that exposure treatments for PTSD can be implemented safely and effectively in a BPD population.


Options:
A: Arm Label: CARMS therapy + TAU; Type: EXPERIMENTAL; Interventions: Other: Cognitive AppRoaches to coMbatting Suicidality (CARMS) | Arm Label: TAU; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: OTHER; Name: Cognitive AppRoaches to coMbatting Suicidality (CARMS); Assigned to Arm(s): CARMS therapy + TAU
B: Arm Label: Brief Cognitive Behavioral Therapy (BCBT); Type: EXPERIMENTAL; Interventions: Behavioral: Brief Cognitive Behavioral Therapy (BCBT) | Arm Label: Treatment As Usual (TAU); Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Treatment As Usual (TAU) | Intervention Type: BEHAVIORAL; Name: Brief Cognitive Behavioral Therapy (BCBT); Assigned to Arm(s): Brief Cognitive Behavioral Therapy (BCBT) | Intervention Type: BEHAVIORAL; Name: Treatment As Usual (TAU); Assigned to Arm(s): Treatment As Usual (TAU)
C: Arm Label: Standard DBT + PTSD Protocol; Type: EXPERIMENTAL; Interventions: Behavioral: Dialectical Behavior Therapy, Behavioral: PTSD Protocol | Arm Label: Standard DBT; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Dialectical Behavior Therapy | Intervention Type: BEHAVIORAL; Name: Dialectical Behavior Therapy; Assigned to Arm(s): Standard DBT, Standard DBT + PTSD Protocol | Intervention Type: BEHAVIORAL; Name: PTSD Protocol; Assigned to Arm(s): Standard DBT + PTSD Protocol
D: Arm Label: Informational Sessions; Type: SHAM_COMPARATOR; Interventions: Behavioral: Informational sessions describing BPD characteristics | Arm Label: Condensed-DBT treatment intervention; Type: EXPERIMENTAL; Interventions: Behavioral: Condensed-DBT treatment intervention | Intervention Type: BEHAVIORAL; Name: Informational sessions describing BPD characteristics; Assigned to Arm(s): Informational Sessions | Intervention Type: BEHAVIORAL; Name: Condensed-DBT treatment intervention; Assigned to Arm(s): Condensed-DBT treatment intervention

Answer: C