Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Evaluation of the Safety and Efficacy of Dihydroartemisinin-piperaquine for Intermittent Preventive Treatment of Malaria in HIV-infected Pregnant Women
Brief Summary: Trial to evaluate the safety and efficacy of DHA-PPQ for Intermittent Preventive Treatment (IPTp) in HIV-infected pregnant women receiving cotrimoxazole prophylaxis (CTXp) and antiretroviral (ARV) drugs and using long lasting insecticide treated nets will be conducted in Mozambique and Gabon where malaria and HIV infection are moderate to highly prevalent. In addition, the possibility for a PK interaction between DHA-PPQ and ARV drugs will be assessed in a sub-sample of participants. Women will receive ARV therapy according to national guidelines and their infants will be followed until one year of age to evaluate the impact of DHA-PPQ on MTCT-HIV.


Options:
A: Arm Label: IPTp-DHA-PPQ; Type: EXPERIMENTAL; Interventions: Drug: Dihydroartemisinin-piperaquine (DHA-PPQ) | Arm Label: IPTp-Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo Oral Tablet | Intervention Type: DRUG; Name: Dihydroartemisinin-piperaquine (DHA-PPQ); Assigned to Arm(s): IPTp-DHA-PPQ | Intervention Type: DRUG; Name: Placebo Oral Tablet; Assigned to Arm(s): IPTp-Placebo
B: Arm Label: 3 dose SP pregnancy / 3 monthly DP infancy; Type: ACTIVE_COMPARATOR; Interventions: Drug: 3 dose sulfadoxine-pyrimethamine (SP) for adult women during pregnancy, Drug: 3-monthly dihydroartemisinin-piperaquine (DP) for infants | Arm Label: 3 dose DP pregnancy / 3 monthly DP infancy; Type: ACTIVE_COMPARATOR; Interventions: Drug: 3 dose dihydroartemisinin-piperaquine (DP) for adult women during pregnancy, Drug: 3-monthly dihydroartemisinin-piperaquine (DP) for infants | Arm Label: 3 dose DP pregnancy / monthly DP infancy; Type: ACTIVE_COMPARATOR; Interventions: Drug: 3 dose dihydroartemisinin-piperaquine (DP) for adult women during pregnancy, Drug: Monthly dihydroartemisinin-piperaquine (DP) for infants | Arm Label: monthly DP pregnancy / 3 monthly DP infancy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Monthly dihydroartemisinin-piperaquine (DP) for adult women during pregnancy, Drug: 3-monthly dihydroartemisinin-piperaquine (DP) for infants | Arm Label: monthly DP pregnancy / monthly DP infancy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Monthly dihydroartemisinin-piperaquine (DP) for adult women during pregnancy, Drug: Monthly dihydroartemisinin-piperaquine (DP) for infants | Intervention Type: DRUG; Name: Monthly dihydroartemisinin-piperaquine (DP) for adult women during pregnancy; Assigned to Arm(s): monthly DP pregnancy / 3 monthly DP infancy, monthly DP pregnancy / monthly DP infancy | Intervention Type: DRUG; Name: 3 dose dihydroartemisinin-piperaquine (DP) for adult women during pregnancy; Assigned to Arm(s): 3 dose DP pregnancy / 3 monthly DP infancy, 3 dose DP pregnancy / monthly DP infancy | Intervention Type: DRUG; Name: 3 dose sulfadoxine-pyrimethamine (SP) for adult women during pregnancy; Assigned to Arm(s): 3 dose SP pregnancy / 3 monthly DP infancy | Intervention Type: DRUG; Name: Monthly dihydroartemisinin-piperaquine (DP) for infants; Assigned to Arm(s): 3 dose DP pregnancy / monthly DP infancy, monthly DP pregnancy / monthly DP infancy | Intervention Type: DRUG; Name: 3-monthly dihydroartemisinin-piperaquine (DP) for infants; Assigned to Arm(s): 3 dose DP pregnancy / 3 monthly DP infancy, 3 dose SP pregnancy / 3 monthly DP infancy, monthly DP pregnancy / 3 monthly DP infancy
C: Intervention Type: DRUG; Name: Monthly sulfadoxine/pyrimethamine; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: 2-dose sulfadoxine/pyrimethamine; Assigned to Arm(s): N/A
D: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: Cotrimoxazole | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Drug: Sulfadoxine-pyrimethamine | Arm Label: 3; Type: EXPERIMENTAL; Interventions: Drug: Cotrimoxazole | Arm Label: 4; Type: ACTIVE_COMPARATOR; Interventions: Drug: Sulfadoxine-pyrimethamine | Intervention Type: DRUG; Name: Cotrimoxazole; Assigned to Arm(s): 1, 3 | Intervention Type: DRUG; Name: Sulfadoxine-pyrimethamine; Assigned to Arm(s): 2, 4

Answer: A