Please select the eligibility criteria that correspond to the clinical trial below.
Title: Neuroscience-Guided Cognitive Remediation in Adolescents at Risk for Psychosis
Brief Summary: This study will evaluate the effectiveness of intensive computerized cognitive training in preventing the onset of psychotic disorder and improving adaptive functioning in adolescents at high risk of schizophrenia.


Options:
A: Inclusion Criteria:

* Participant in VA work services
* Chronic and disabling psychiatric illness

Exclusion Criteria:

* Neurological Disease that may affect cognition
* Primary substance abuse
* Developmental Disability
B: Inclusion Criteria:

1. Subjects must be between 18 and 65 years old, inclusive, at the time of study screening
2. Subjects must have a diagnosis of schizophrenia as defined by an interview.
3. Subjects must demonstrate adequate decisional capacity, in the judgment of the consenting study staff member, to make a choice about participating in this research study.
4. Subjects must have been clinically stable (non-acute) for 8 weeks prior to consent; in the judgment of the Site Principal Investigator.
5. Subjects must have been maintained on a stable treatment of antipsychotics and/or other concomitant psychotropic treatment for at least 6 weeks prior to consent.
6. Subjects must have learned English before the age of 12 to ensure valid neuropsychological results.
7. Subjects must have the visual, auditory, and motor capacity to use the computerized intervention in the judgment of the consenting study staff person.
8. Subjects must have no more than a moderately severe rating on hallucinations and unusual thought content.

Exclusion Criteria:

1. Subjects should not have had a psychiatric hospitalization in the 8 weeks prior to consent.
2. Subjects who appear to be intoxicated or under the influence of a controlled substance on any day of assessment must be rescheduled or discontinued based upon the discretion of the site staff evaluator.
3. Subjects should not have a history of mental retardation or pervasive developmental disorder; or other neurological disorder (e.g., Traumatic Brain Injury, epilepsy, Parkinson's Disease.)
4. Subjects should not have been treated within 3 years of the date of consent with a computer-based cognitive training program manufactured by Posit Science.
5. Subjects should not be participating in a concurrent clinical trial that, in the judgment of the Site Principal Investigator, could affect the outcome of this one.
6. Subjects must not show suicidal ideation or behaviors.
C: Inclusion Criteria:

* Clinical diagnosis of schizophrenia or schizoaffective disorder
* Between 18-65 years of age
* Clinically stable
* Fluent in English

Exclusion Criteria:

* Recent hospitalization, in the past 3 months
* History of traumatic brain injury
* Neurological disorders
* Inability to participate in the study soberly
D: Inclusion Criteria:

* Meets criteria from the Structured Interview of Prodromal Syndromes for the diagnosis of a prodromal syndrome
* Good general physical health
* English is first language
* Clinically stable (e.g., outpatient status for at least 8 weeks before study entry;on stable doses of medications for at least 1 month before study entry)

Exclusion Criteria:

* Confirmed neurological disorder

Answer: D