Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Comparative Study of Influenza Vaccines in Adults - FLU-VACS
Brief Summary: The purpose of this study is to compare 2 licensed flu vaccines to each other and to placebo (inactive substance). The study will be conducted among healthy adult participants aged 18-49 years and is expected to last 3 years. During year 1, participants will be assigned to receive 1 of the 2 licensed flu vaccines or placebo, given as either nasal spray (live-attenuated vaccine or placebo) or injection (inactivated vaccine or placebo). Participants will receive the same assigned vaccine or placebo during year 2. During year 3, participants will be followed, but will not receive flu vaccine. Each year blood samples will be collected before and 1 month after each vaccination and at the end of each flu season in order to measure how the body responds to the vaccine and how well participants were protected from the flu. During the flu season, participants with flu-like illness will provide information on symptoms and provide a throat swab to test for virus identification.


Options:
A: Intervention Type: BIOLOGICAL; Name: CAIV-T; Assigned to Arm(s): N/A
B: Arm Label: Group 4: Placebo: Intramuscular; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Arm Label: Group 3: Placebo: Nasal; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo | Arm Label: Group 1: FluMist™; Type: EXPERIMENTAL; Interventions: Biological: Cold-adapted live attenuated influenza virus vaccine, trivalent | Arm Label: Group 2: Fluzone®/Fluvirin; Type: EXPERIMENTAL; Interventions: Biological: Trivalent inactivated influenza vaccine | Intervention Type: BIOLOGICAL; Name: Cold-adapted live attenuated influenza virus vaccine, trivalent; Assigned to Arm(s): Group 1: FluMist™ | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Group 4: Placebo: Intramuscular | Intervention Type: BIOLOGICAL; Name: Trivalent inactivated influenza vaccine; Assigned to Arm(s): Group 2: Fluzone®/Fluvirin | Intervention Type: BIOLOGICAL; Name: Trivalent inactivated influenza vaccine; Assigned to Arm(s): Group 2: Fluzone®/Fluvirin | Intervention Type: OTHER; Name: Placebo; Assigned to Arm(s): Group 3: Placebo: Nasal
C: Arm Label: Influenza A (H5N1) 18-64Y Group; Type: EXPERIMENTAL; Interventions: Biological: Influenza A (H5N1) Virus Monovalent Vaccine, Adjuvanted | Arm Label: Placebo 18-64Y Group; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Arm Label: Influenza A (H5N1) >64Y Group; Type: EXPERIMENTAL; Interventions: Biological: Influenza A (H5N1) Virus Monovalent Vaccine, Adjuvanted | Arm Label: Placebo >64Y Group; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Arm Label: Influenza A (H5N1) Group; Type: EXPERIMENTAL; Interventions: Biological: Influenza A (H5N1) Virus Monovalent Vaccine, Adjuvanted | Arm Label: Placebo Group; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Arm Label: Influenza A (H5N1) 18-60Y Group; Type: EXPERIMENTAL; Interventions: Biological: Influenza A (H5N1) Virus Monovalent Vaccine, Adjuvanted | Arm Label: Placebo 18-60Y Group; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Arm Label: Influenza A (H5N1) >60Y Group; Type: EXPERIMENTAL; Interventions: Biological: Influenza A (H5N1) Virus Monovalent Vaccine, Adjuvanted | Arm Label: Placebo >60Y Group; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo | Intervention Type: BIOLOGICAL; Name: Influenza A (H5N1) Virus Monovalent Vaccine, Adjuvanted; Assigned to Arm(s): Influenza A (H5N1) 18-60Y Group, Influenza A (H5N1) 18-64Y Group, Influenza A (H5N1) >60Y Group, Influenza A (H5N1) >64Y Group, Influenza A (H5N1) Group | Intervention Type: BIOLOGICAL; Name: Placebo; Assigned to Arm(s): Placebo 18-60Y Group, Placebo 18-64Y Group, Placebo >60Y Group, Placebo >64Y Group, Placebo Group
D: Arm Label: split-virion, adjuvanted H1N1 vaccine of 7.5 μg; Type: EXPERIMENTAL; Interventions: Biological: Experimental: split-virion, adjuvanted H1N1 vaccine of 7.5 μg | Arm Label: split-virion, adjuvanted H1N1 vaccine of 15 μg; Type: EXPERIMENTAL; Interventions: Biological: Experimental: split-virion, adjuvanted H1N1 vaccine of 15 μg | Arm Label: split-virion, adjuvanted H1N1 vaccine of 30 μg; Type: EXPERIMENTAL; Interventions: Biological: Experimental: split-virion, adjuvanted H1N1 vaccine of 30 μg | Arm Label: split-virion, non-adjuvanted H1N1 vaccine of 15 μg; Type: EXPERIMENTAL; Interventions: Biological: Experimental: split-virion, non-adjuvanted H1N1 vaccine of 15 μg | Arm Label: Placebo control; Type: PLACEBO_COMPARATOR; Interventions: Biological: Placebo Comparator: Placebo control | Arm Label: split-virion, non-adjuvanted H1N1 vaccine of 30 μg; Type: EXPERIMENTAL; Interventions: Biological: split-virion, non-adjuvanted H1N1 vaccine of 30 μg | Intervention Type: BIOLOGICAL; Name: split-virion, non-adjuvanted H1N1 vaccine of 30 μg; Assigned to Arm(s): split-virion, non-adjuvanted H1N1 vaccine of 30 μg | Intervention Type: BIOLOGICAL; Name: Experimental: split-virion, adjuvanted H1N1 vaccine of 7.5 μg; Assigned to Arm(s): split-virion, adjuvanted H1N1 vaccine of 7.5 μg | Intervention Type: BIOLOGICAL; Name: Experimental: split-virion, adjuvanted H1N1 vaccine of 15 μg; Assigned to Arm(s): split-virion, adjuvanted H1N1 vaccine of 15 μg | Intervention Type: BIOLOGICAL; Name: Experimental: split-virion, adjuvanted H1N1 vaccine of 30 μg; Assigned to Arm(s): split-virion, adjuvanted H1N1 vaccine of 30 μg | Intervention Type: BIOLOGICAL; Name: Experimental: split-virion, non-adjuvanted H1N1 vaccine of 15 μg; Assigned to Arm(s): split-virion, non-adjuvanted H1N1 vaccine of 15 μg | Intervention Type: BIOLOGICAL; Name: Placebo Comparator: Placebo control; Assigned to Arm(s): Placebo control

Answer: B