TrialPanorama/Dataset huggingface dataset:
Please select the outcome measures that correspond to the clinical trial below.
Title: Effects of Food Form and Fitness on Appetite and Digestion.
Brief Summary: Energy-yielding fluids induce weaker appetitive and compensatory dietary responses than energy-matched semi-solids or solids. This is problematic because the high and increasing contribution of energy from beverages in the diet may enhance positive energy balance and weight gain. The prevailing view of the overweight/obesity problem is that it stems from a small, sustained positive energy balance. It follows then that only small changes, perhaps manipulations in the rheological characteristics of the diet, will be required to correct the problem. Certain populations that are more prone to weight gain may benefit from such manipulations. Obese individuals have a higher beverage intake and experience greater weight loss with reductions in beverage intake. Further, there is evidence that obese individuals consume more energy after a liquid pre-load than their lean counterparts, yet there is no difference in energy intake after a solid load. In contrast, habitual exercisers have been shown to have an increased accuracy of short-term regulation of food intake at meals following liquid preloads. A better understanding of the mechanisms by which beverages and energy-matched solid food forms elicit differential appetitive and dietary responses in these populations needed. This research will attempt to identify the influence of physical fitness and body fat on the ability to compensate for the energy content of solid and liquid preloads by reduction in energy intake at a subsequent ad libitum meal (i.e., acute compensation) and over the course of the day (i.e., short-term compensation). Furthermore, this study will examine the cognitive contribution to differential responses to energy-matched beverage and solid food forms and the effects of mastication on appetite, GI transit, glycemic response, and selected endocrine responses.


Options:
A: Purchase of sugar-sweetened beverages (4 months)
B: Change of energy intake. (24 hours)
C: Body mass index (BMI) >= 85th percentile, adjusted for gender and age (baseline, end of 7th grade, end of study); Fasting glucose (mg/dL) (baseline, end of study); Fasting insulin (mU/mL) (baseline, end of study)
D: Change in body weight from baseline (4 weeks)

Answer: B
Please select the outcome measures that correspond to the clinical trial below.
Title: Duloxetine Versus Placebo in the Acute Treatment of Patients With Major Depressive Disorder and Associated Painful Physical Symptoms
Brief Summary: The purpose of this study is to find out if 60 mg of duloxetine given once a day by mouth for 8 weeks to patients diagnosed with major depressive disorder, who also report associated painful physical symptoms, is better than placebo when treating depression and its associated painful symptoms.


Options:
A: Change From Week 8 to Week 16 Endpoint in 24 Hour Average Pain Item Score on the Brief Pain Inventory (BPI) Modified Short Form (Week 8, Week 16)
B: Change From Baseline in the Brief Pain Inventory-Short Form (BPI-SF) Average Pain Score During the 8-Week Treatment Period (Day 1 through 8 weeks); Change From Baseline in the Montgomery-Asberg Depression Rating Scale (MADRS) Total Score at Week 8 (Baseline, 8 weeks)
C: Patient's Global Impressions of Improvement (PGI-I) at Week 12 (12 weeks)
D: assess efficacy of duloxetine (QD) vs placebo on pain in patients, w/ or w/o MDD during a 6-month therapy phase; evaluate change in pain measured by Brief Pain Inventory score; evaluate endpoint of patient-reported improvement on the Patient's Global Impression of Improvement scale

Answer: B
Please select the outcome measures that correspond to the clinical trial below.
Title: Evaluation of Pharmacokinetics and Profile of Clinical Response of Subacute Lisdexamfetamine Dimesylate (Vyvanse) Treatment vs. Clinical Response to Subacute Immediate Release Mixed Amphetamine Salt Therapy in Adult ADHD
Brief Summary: The purpose of this study is to examine the effectiveness and length of effect of Vyvanse on lessening Attention-Deficit/Hyperactivity Disorder symptoms in adults. The study will also investigate the safety and tolerability of Vyvanse in adults with ADHD.


Options:
A: Attention Deficit Hyperactivity Disorder- Rating Scale (ADHS-RS) (12 weeks)
B: Change from Baseline in the ADHD-rating scale 4th Edition (ADHD-RS-IV) total score to the Endpoint assessment. (Baseline, and the Endpoint (average of weeks 5, 6, 7).)
C: Maximum Plasma Concentration (Cmax) of d-Amphetamine for Vyvanse and Adderall XR Alone and in Combination With Prilosec OTC (0 through 96 hours after dosing); Time of Maximum Plasma Concentration (Tmax) of d-Amphetamine for Vyvanse and Adderall XR Alone and in Combination With Prilosec OTC (0 through 96 hours after dosing); Area Under the Steady-state Plasma Concentration-time Curve (AUC) of d-Amphetamine for Vyvanse and Adderall XR Alone and in Combination With Prilosec OTC (0 through 96 hours after dosing); Terminal Half-life (T 1/2) of d-Amphetamine for Vyvanse and Adderall XR Alone and in Combination With Prilosec OTC (0 through 96 hours after dosing); Cmax of l-Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC (0 through 96 hours after dosing); Tmax of l-Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC (0 through 96 hours after dosing); AUC of l-Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC (0 through 96 hours after dosing); T 1/2 of l-Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC (0 through 96 hours after dosing); Cmax of Total Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC (0 through 96 hours after dosing); Tmax of Total Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC (0 through 96 hours after dosing); AUC of Total Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC (0 through 96 hours after dosing); T 1/2 of Total Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC (0 through 96 hours after dosing)
D: Change from baseline in the sum of the inattention and hyperactivity/impulsivity subscale scores of the investigator-rated Conners' Adult ADHD Rating Scale at the end of the double-blind phase (5 weeks) compared with placebo.

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: The Effect of an Aerobic Training Programme on the Aerobic Capacity, Functional Behavior and the Cardiovascular Risk Factors in Stroke Patients
Brief Summary: This study aims to investigate the effect of aerobic exercise on the aerobic capacity, the daily functioning, post-stroke fatigue , depression and cardiovascular risk factors in stroke patients.


Options:
A: VO2-peak, strength, walking, activities of daily living (baseline , after 12 weeks training. Follow-up measurements after 6 months, 1 and 2 years after baseline.)
B: modified Rankin Score (3 months)
C: Trunk Impairment Scale Norwegian Version (12 weeks); ActiGraph WgtX-BT (13 weeks)
D: Glucose area under the curve (0 weeks and 2 weeks)

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: The Effect of an Aerobic Training Programme on the Aerobic Capacity, Functional Behavior and the Cardiovascular Risk Factors in Stroke Patients
Brief Summary: This study aims to investigate the effect of aerobic exercise on the aerobic capacity, the daily functioning, post-stroke fatigue , depression and cardiovascular risk factors in stroke patients.


Options:
A: Change in 10 meter walk test (Pre Test, 4 weeks, 8 weeks, 3 month follow up)
B: VO2-peak, strength, walking, activities of daily living (baseline , after 12 weeks training. Follow-up measurements after 6 months, 1 and 2 years after baseline.)
C: Upper Extremity motor control of Fugl-Meyer Assessment (FMA-UE) (before and after 4 weeks intervention)
D: Subjective Index of Physical and Social Outcome (SIPSO) (baseline and 1 year); Subjective Index of Social Integration (Subscale of SIPSO) (baseline and one year); Subjective Index of Physical Integration (Subscale of SIPSO) (baseline and one year)

Answer: B
Please select the outcome measures that correspond to the clinical trial below.
Title: Phase III (c) The Effect of Azithromycin in Patients With COPD and Chronic Productive Cough
Brief Summary: The purpose of this study is to demonstrate the efficacy of azithromycin to produce a significant change in the cough-related health status, measured with the Dutch version of the Leicester Cough Questionnaire in patiënts with COPD gold classification 2-4 and chronic productive coughing.


Options:
A: Mean change in the Leicester Cough Questionnaire (LCQ) scores. (2 years)
B: Time to clinical failure (Will be assessed between day 1 (from 1 hour after first drug intake) till day 90 (24 hours after last study drug intake))
C: Exacerbation Frequency; Airway Inflammation
D: myeloperoxidase in induced sputum (3 weeks)

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: Phase III (c) The Effect of Azithromycin in Patients With COPD and Chronic Productive Cough
Brief Summary: The purpose of this study is to demonstrate the efficacy of azithromycin to produce a significant change in the cough-related health status, measured with the Dutch version of the Leicester Cough Questionnaire in patiënts with COPD gold classification 2-4 and chronic productive coughing.


Options:
A: Number of exacerbations after 48 weeks of intermittent pulse treatment (After 48 weeks of treatment)
B: Exacerbation Frequency; Airway Inflammation
C: Overall Survival (Up to 9 years); Progression-free Survival (From the date of enrollment to first progression or death or last contact, if alive and progression free.)
D: Mean change in the Leicester Cough Questionnaire (LCQ) scores. (2 years)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Phase III (c) The Effect of Azithromycin in Patients With COPD and Chronic Productive Cough
Brief Summary: The purpose of this study is to demonstrate the efficacy of azithromycin to produce a significant change in the cough-related health status, measured with the Dutch version of the Leicester Cough Questionnaire in patiënts with COPD gold classification 2-4 and chronic productive coughing.


Options:
A: Clinical Attachment Level (6 months)
B: Number of Unscheduled Face-to-face Physician Visits (Clinic Visits, ER Visits, and Hospitalizations) (5 to 8 months)
C: degree of food stasis (when endoscopy is performed.)
D: Mean change in the Leicester Cough Questionnaire (LCQ) scores. (2 years)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Remote Ischemic Preconditioning in Cardiac Surgery: a Pilot Randomized Controlled Trial
Brief Summary: Main Research Questions:

1. Is a large trial of patients undergoing heart surgery comparing a simple procedure of temporarily stopping blood flow to the leg with a blood pressure cuff (called remote ischemic preconditioning) to a sham procedure possible?
2. Does the remote ischemic preconditioning procedure before heart surgery help protect the heart and kidneys?

What is Being Studied:

A simple procedure known as remote ischemic preconditioning. The procedure is performed by inflating a pressurized cuff the thigh to temporarily stop blood flow to the arm or leg. This procedure causes the body to have a stress response that, at the cellular level, may protect major organs like the heart and kidney from the damage caused to them by the much larger stress of cardiac surgery. Reducing this damage may improve patient's recovery after surgery and help them live longer.

Why is this study important?:

This research is important because up to 1 in every 20 patients that undergo heart surgery die before even leaving hospital. Preventing heart and kidney damage at the time of surgery with remote ischemic preconditioning may reduce patient deaths.


Options:
A: The primary outcome measure is postoperative neurocognitive dysfunction. (Preoperative, 1 week and 3 months after surgery)
B: Mitochondrial respiration (1 hour)
C: Peak CK-MB within 24 hours after surgery (24 hours)
D: Perioperative extent of myocardial injury as measured by cardiac troponin I serum release over 72 hours after CABG surgery and its area under the curve (AUC). (72 hours postoperatively after CABG surgery)

Answer: C
Please select the outcome measures that correspond to the clinical trial below.
Title: The Effect After 12 Weeks of Having Received a Pedometer and a Pedometer Program on Physical Activity, Health Measurements, Self-rated Health, Stress, and Sleep Quality: a Randomized Controlled Trial
Brief Summary: Physical activity is associated with a reduced risk of several chronic diseases in addition to all-cause mortality. Hence for public health purposes, knowledge of effective interventions to increase the physical activity level in the population is important.

The objective of this randomized controlled trial was to examine the effect 12 weeks after having received a pedometer and a pedometer program on physical activity, health measurements, self-rated health, stress, and sleep quality.

A total of 223 men and 445 women were randomly assigned to either a pedometer group (n = 333) in which participants received a pedometer and pedometer program or a control group (n = 335). Of the participants included in the study 198 and 178 completed the health examination, and 192 and 187 completed the questionnaire at follow up in the pedometer group and in the control group, respectively.


Options:
A: Physical activity (walking time, sitting time, physical activity level in leisure time) (12 weeks)
B: Feasibility and acceptability of intervention (2 months)
C: Aerobic Fitness; Resting Blood Pressure; Body Fatness; Blood Lipids; C-reactive Protein
D: Primary outcome measure was step count (6-weeks)

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: Effect of a Longitudinal, Multifactorial Community-based Nursing Intervention on Mortality in Chronically Ill Older Adults
Brief Summary: Care coordination, disease management, geriatric care management, and preventive programs for chronically ill older adults vary in design and their impact on long-term health outcomes is not well established. This study investigates whether a community-based nursing intervention improves longevity and impact on cardiovascular risk factors in this population. The results reflect the impact of one of the study sites (Health Quality Partners) selected by the Centers for Medicare and Medicaid Services (CMS) to participate in the Medicare Coordinated Care Demonstration, a national demonstration designed to identify promising models of care coordination for chronically ill older adults. The study began in April 2002.


Options:
A: Composite: Proportion of patients with any risk factor as defined in secondary outcome measures to 9, who have received any high risk prescriptions of anti-inflammatory drugs or antiplatelets as defined in secondary outcome measures 1 to 9 (8 weeks)
B: All-cause mortality (within 5 years of enrollment)
C: New Advance Care Planning Documentation in the Medical Record at 9 Months (9 months after study enrollment)
D: Combined Effect of Intervention on SCL-20, Systolic Blood Pressure, LDL and HbA1c (Baseline to 12 months); Symptom Checklist-20 Score at Baseline, 6 Months and 12 Months (Measured at Baseline, 6 Months, 12 months); Systolic Blood Pressure at Baseline, 6 Months and 12 Months (Measured at Baseline, 6 Months, 12 months); LDL Cholesterol at Baseline and 12 Months (Measured at Baseline and 12 months); Glycated Hemoglobin (HbA1c) at Baseline, 6 Months and 12 Months (Measured at Baseline, 6 months and 12 months)

Answer: B
Please select the outcome measures that correspond to the clinical trial below.
Title: Effect of a Longitudinal, Multifactorial Community-based Nursing Intervention on Mortality in Chronically Ill Older Adults
Brief Summary: Care coordination, disease management, geriatric care management, and preventive programs for chronically ill older adults vary in design and their impact on long-term health outcomes is not well established. This study investigates whether a community-based nursing intervention improves longevity and impact on cardiovascular risk factors in this population. The results reflect the impact of one of the study sites (Health Quality Partners) selected by the Centers for Medicare and Medicaid Services (CMS) to participate in the Medicare Coordinated Care Demonstration, a national demonstration designed to identify promising models of care coordination for chronically ill older adults. The study began in April 2002.


Options:
A: composite of all-cause mortality, non-fatal myocardial infarction, non-fatal stroke (every six months for an average of 5.4 years)
B: Cardiac Medication Use (3 and 12 months)
C: The reduction of systolic blood pressure in the nurse administered intervention will be 5 mm hg lower than those patients randomized to an education control group over 12 months of follow-up (12 months)
D: All-cause mortality (within 5 years of enrollment)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Effect of a Longitudinal, Multifactorial Community-based Nursing Intervention on Mortality in Chronically Ill Older Adults
Brief Summary: Care coordination, disease management, geriatric care management, and preventive programs for chronically ill older adults vary in design and their impact on long-term health outcomes is not well established. This study investigates whether a community-based nursing intervention improves longevity and impact on cardiovascular risk factors in this population. The results reflect the impact of one of the study sites (Health Quality Partners) selected by the Centers for Medicare and Medicaid Services (CMS) to participate in the Medicare Coordinated Care Demonstration, a national demonstration designed to identify promising models of care coordination for chronically ill older adults. The study began in April 2002.


Options:
A: Prevalence of latent heart failure and COPD. (6 months)
B: Change in Hemoglobin A1C (Hemoglobin A1C levels will be measured at baseline, 6-, and 12- months.); Change in Patient Health Questionnaires-9 During Intervention (PHQ-9 will be assessed at baseline, 6-, and 12- months.)
C: Comorbidities treatment (6 months later); Auto-DAS: Patient education to calculate his Disease Activity Score (6 months after)
D: All-cause mortality (within 5 years of enrollment)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Effect of a Longitudinal, Multifactorial Community-based Nursing Intervention on Mortality in Chronically Ill Older Adults
Brief Summary: Care coordination, disease management, geriatric care management, and preventive programs for chronically ill older adults vary in design and their impact on long-term health outcomes is not well established. This study investigates whether a community-based nursing intervention improves longevity and impact on cardiovascular risk factors in this population. The results reflect the impact of one of the study sites (Health Quality Partners) selected by the Centers for Medicare and Medicaid Services (CMS) to participate in the Medicare Coordinated Care Demonstration, a national demonstration designed to identify promising models of care coordination for chronically ill older adults. The study began in April 2002.


Options:
A: The primary outcome is defined by the number of patients free from clinically relevant adverse treatment events and/or drug interactions in each treatment arm at end of study. (6 months)
B: Health Care Consumption (1 year); Dependence in Activities of Daily Living (1 year); Satisfaction With Health and Social Care (1 year)
C: All-cause mortality (within 5 years of enrollment)
D: Mean # Participants Who Had Hospitalizations or ED Visits Compared to Usual Care in a High Risk Group of Adults ≥ 60 Years of Age With Mixed Chronic Disease. (12 months)

Answer: C
Please select the outcome measures that correspond to the clinical trial below.
Title: Work Place Adjusted Intelligent Physical Exercise Reducing Musculoskeletal Pain in Shoulder and Neck (VIMS) - Industrial Workers
Brief Summary: The purpose of this study is to investigate the effect of specific resistance training on neck/shoulder pain in industrial workers.


Options:
A: Pain of the neck and shoulders (At week 0 (baseline) and week 20 (follow-up)); Pain in the arm/hand (At week 0 (baseline) and week 20 (follow-up))
B: Sick leave (2 years)
C: Oswestry Disability Index (3 months)
D: Modified Oswestry Disability Index (12 months)

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: Work Place Adjusted Intelligent Physical Exercise Reducing Musculoskeletal Pain in Shoulder and Neck (VIMS) - Industrial Workers
Brief Summary: The purpose of this study is to investigate the effect of specific resistance training on neck/shoulder pain in industrial workers.


Options:
A: Pain of the neck and shoulders (At week 0 (baseline) and week 20 (follow-up)); Pain in the arm/hand (At week 0 (baseline) and week 20 (follow-up))
B: Pain (Measured 3 months after the accident); Functional activity (Measured 3 months after the accident); Mood (Measured 3 months after the accident)
C: Reduction in number of days per month with headache and shoulders pain after 6 months.Proportion of subjects with more than 4 days with headache and shoulder pain at the baseline that will have reduction in pain frequency of more than 50%, after 6 months (6 months)
D: Return-to-work=the proportion of patients who during 1-18 months regained a degree of work ability>0 for at least 30 days in succession. (18 months.)

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: Work Place Adjusted Intelligent Physical Exercise Reducing Musculoskeletal Pain in Shoulder and Neck (VIMS) - Industrial Workers
Brief Summary: The purpose of this study is to investigate the effect of specific resistance training on neck/shoulder pain in industrial workers.


Options:
A: Neck Disability Index (4 weeks, 6 months)
B: Patient-rated pain (0-10 scale, 11 box) (short term = 12 weeks; long term = 52 weeks)
C: Reduction in number of days per month with headache and shoulders pain after 6 months.Proportion of subjects with more than 4 days with headache and shoulder pain at the baseline that will have reduction in pain frequency of more than 50%, after 6 months (6 months)
D: Pain of the neck and shoulders (At week 0 (baseline) and week 20 (follow-up)); Pain in the arm/hand (At week 0 (baseline) and week 20 (follow-up))

Answer: D