Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Routine Administration of Folic Acid and Vitamin B12 to Prevent Childhood Infections in Young Indian Children
Brief Summary: Hypothesis: Supplementation of two recommended daily allowances (RDA) of folic acid with or without simultaneous administration of vitamin B12 reduces the rates of acute lower respiratory tract infections (ALRI), clinical pneumonia and diarrhea.

Design/Methods We will conduct a preventive randomized placebo controlled clinical trial of folic acid and vitamin B12 supplementation in 1000 children aged 6 to 30 months living in a low to middle-income socioeconomic setting in New Delhi, India. Children aged 6-30 months will be identified through a survey. Eligible and willing Children aged 6-30 months will be randomized to 4 treatment groups. Trial to enrollment informed consent will be obtained by the Study Physician/Supervisor. At enrollment a baseline form will be filled and the child weight and length taken. The baseline blood samples will be collected. The supplements will be given daily for 6 months. Morbidity will be ascertained through biweekly home visits by field workers.


Options:
A: Arm Label: micronutrient powder (MNP); Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: MNP, Dietary Supplement: therapeutic placebo supplement | Arm Label: placebo powder; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: therapeutic placebo supplement, Dietary Supplement: placebo powder | Arm Label: preventive zinc supplements; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: preventive zinc supplement, Dietary Supplement: therapeutic placebo supplement | Arm Label: therapeutic zinc supplements; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: therapeutic zinc supplement, Dietary Supplement: preventive placebo supplement | Intervention Type: DIETARY_SUPPLEMENT; Name: MNP; Assigned to Arm(s): micronutrient powder (MNP) | Intervention Type: DIETARY_SUPPLEMENT; Name: preventive zinc supplement; Assigned to Arm(s): preventive zinc supplements | Intervention Type: DIETARY_SUPPLEMENT; Name: therapeutic zinc supplement; Assigned to Arm(s): therapeutic zinc supplements | Intervention Type: DIETARY_SUPPLEMENT; Name: preventive placebo supplement; Assigned to Arm(s): therapeutic zinc supplements | Intervention Type: DIETARY_SUPPLEMENT; Name: therapeutic placebo supplement; Assigned to Arm(s): micronutrient powder (MNP), placebo powder, preventive zinc supplements | Intervention Type: DIETARY_SUPPLEMENT; Name: placebo powder; Assigned to Arm(s): placebo powder
B: Arm Label: A; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo | Arm Label: B; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Folic Acid | Arm Label: C; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Vitamin B12 | Arm Label: D; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Folic acid and vitamin B12 | Intervention Type: DIETARY_SUPPLEMENT; Name: Folic Acid; Assigned to Arm(s): B | Intervention Type: DIETARY_SUPPLEMENT; Name: Vitamin B12; Assigned to Arm(s): C | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo; Assigned to Arm(s): A | Intervention Type: DIETARY_SUPPLEMENT; Name: Folic acid and vitamin B12; Assigned to Arm(s): D
C: Arm Label: Zinc sulphate; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Zinc sulfate as dietary supplementation | Arm Label: Zinc Amino Acid Chelate; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Zinc amino acid chelate as dietary supplementation | Arm Label: Milk without fortification; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Milk without fortification without zinc | Intervention Type: DIETARY_SUPPLEMENT; Name: Zinc sulfate as dietary supplementation; Assigned to Arm(s): Zinc sulphate | Intervention Type: DIETARY_SUPPLEMENT; Name: Zinc amino acid chelate as dietary supplementation; Assigned to Arm(s): Zinc Amino Acid Chelate | Intervention Type: DIETARY_SUPPLEMENT; Name: Milk without fortification without zinc; Assigned to Arm(s): Milk without fortification
D: Arm Label: Zinc fortified group; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Zinc fortified food, Other: Placebo supplement | Arm Label: Non-fortified group; Type: PLACEBO_COMPARATOR; Interventions: Other: Placebo supplement, Dietary Supplement: Non-fortified food | Arm Label: Zinc supplement group; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Zinc supplement, Dietary Supplement: Non-fortified food | Intervention Type: DIETARY_SUPPLEMENT; Name: Zinc fortified food; Assigned to Arm(s): Zinc fortified group | Intervention Type: DIETARY_SUPPLEMENT; Name: Zinc supplement; Assigned to Arm(s): Zinc supplement group | Intervention Type: OTHER; Name: Placebo supplement; Assigned to Arm(s): Non-fortified group, Zinc fortified group | Intervention Type: DIETARY_SUPPLEMENT; Name: Non-fortified food; Assigned to Arm(s): Non-fortified group, Zinc supplement group

Answer: B