Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Preventing Atopic Dermatitis and ALLergies in Children
Brief Summary: The primary objective is of the PreventADALL study is to test if primary prevention of allergic diseases is possible by simple and low cost strategies, and secondary to asses the impact of xenobiotic exposure and microbiota in and on the body and the environment on allergic disease development.

The secondary objective is an exploratory focus to investigate early life risk factors for development of non-communicable diseases, including asthma and allergic diseases as well as for diseases that may share common risk factors, including cardiovascular disease, obesity and diabetes.

Design: A multi-national population-based prospective birth cohort with a factorial designed randomized controlled intervention trial of two clinical interventions; skin care 0-9 months and early food introduction by 3-4 months, thereafter observation only.

Recruitment in three cities (Oslo, Ostfold and Stockholm) of approximately 2500 mother-child pairs is done in two steps; first pregnant women are recruited and enrolled at the 18-weeks ultrasound investigation (n=approximately 2700) and thereafter their new-born babies are included.

Randomization into four groups is done by the postal code or "township" to ensure all four intervention-groups within each "township".

Visits for biological and environmental sampling, observations and investigations will be at the relevant pediatric departments (at 3-6-12-24-36 months of age) and through childhood into adulthood thereafter, provided sufficient funding.


Options:
A: Arm Label: Domestic ion-exchange water softener; Type: EXPERIMENTAL; Interventions: Device: Domestic ion-exchange water softener | Arm Label: Usual hard water supply; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DEVICE; Name: Domestic ion-exchange water softener; Assigned to Arm(s): Domestic ion-exchange water softener
B: Arm Label: Twice daily use treatment with EpiCeram; Type: ACTIVE_COMPARATOR; Interventions: Drug: EpiCeram | Arm Label: Standard skin care; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DRUG; Name: EpiCeram; Assigned to Arm(s): Twice daily use treatment with EpiCeram
C: Arm Label: Daily Emollient; Type: EXPERIMENTAL; Interventions: Other: Participant choice of over-the-counter emollients: Vaseline, Vanicream, CeraVe Healing Ointment, CeraVe cream, Cetaphil cream | Arm Label: Natural Skin; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: OTHER; Name: Participant choice of over-the-counter emollients: Vaseline, Vanicream, CeraVe Healing Ointment, CeraVe cream, Cetaphil cream; Assigned to Arm(s): Daily Emollient
D: Arm Label: Observation only; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Food intervention; Type: EXPERIMENTAL; Interventions: Other: Food intervention | Arm Label: Skin care; Type: EXPERIMENTAL; Interventions: Other: Skin care | Arm Label: Food intervention and skin care; Type: EXPERIMENTAL; Interventions: Other: Food intervention, Other: Skin care | Intervention Type: OTHER; Name: Food intervention; Assigned to Arm(s): Food intervention, Food intervention and skin care | Intervention Type: OTHER; Name: Skin care; Assigned to Arm(s): Food intervention and skin care, Skin care

Answer: D