Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Targeted Disruption to Cancer Metabolism Through Dietary Macronutrient Modification
Brief Summary: The objective of this investigation is to examine the effects of 12 weeks of usual care plus a ketogenic diet (KD) or usual care plus dietary recommendations endorsed by the Academy of Nutrition and Dietetics (AND) in women with ovarian and endometrial cancer. Participants undergo testing at baseline and at 12 weeks; the testing consists of blood draws, questionnaires, and measures of body composition. The baseline visit also includes a meeting with a registered dietitian to discuss the guidelines of the assigned diet.

It is hypothesized that the KD group will have improved cancer outcome measures, beneficial body composition changes, reduced fasting concentrations of glucose and insulin, and higher ratings of patient satisfaction with the diet relative to the AND group.


Options:
A: Arm Label: Less Intensive Group; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Less Intensive | Arm Label: Intensive Group; Type: EXPERIMENTAL; Interventions: Behavioral: Intensive Group | Intervention Type: BEHAVIORAL; Name: Less Intensive; Assigned to Arm(s): Less Intensive Group | Intervention Type: BEHAVIORAL; Name: Intensive Group; Assigned to Arm(s): Intensive Group
B: Arm Label: Wait-list control; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Lifestyle counseling; Type: EXPERIMENTAL; Interventions: Behavioral: behavioral dietary and exercise intervention | Intervention Type: BEHAVIORAL; Name: behavioral dietary and exercise intervention; Assigned to Arm(s): Lifestyle counseling
C: Arm Label: Usual care plus ketogenic diet; Type: EXPERIMENTAL; Interventions: Other: Ketogenic diet | Arm Label: Usual care plus AND diet; Type: PLACEBO_COMPARATOR; Interventions: Other: AND diet | Intervention Type: OTHER; Name: Ketogenic diet; Assigned to Arm(s): Usual care plus ketogenic diet | Intervention Type: OTHER; Name: AND diet; Assigned to Arm(s): Usual care plus AND diet
D: Arm Label: Arm 1: ScaleDown (only first 16 patients); Type: EXPERIMENTAL; Interventions: Behavioral: ScaleDown, Behavioral: Enhanced Usual Care Packets, Other: 12-Item Short Form Health Survey, Other: International Physical Activity Questionnaire short form, Other: Multidimensional Body Self Relations Questionnaire - Appearance Subscales, Other: Cancer-Related Body Image Scale, Other: Patient Health Questionnaire 9-Item Version | Arm Label: Arm 2: Enhanced Usual Care; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Enhanced Usual Care Packets, Other: 12-Item Short Form Health Survey, Other: International Physical Activity Questionnaire short form, Other: Multidimensional Body Self Relations Questionnaire - Appearance Subscales, Other: Cancer-Related Body Image Scale, Other: Patient Health Questionnaire 9-Item Version | Arm Label: Arm 3: iOTA; Type: EXPERIMENTAL; Interventions: Behavioral: Enhanced Usual Care Packets, Other: 12-Item Short Form Health Survey, Other: International Physical Activity Questionnaire short form, Other: Multidimensional Body Self Relations Questionnaire - Appearance Subscales, Other: Cancer-Related Body Image Scale, Other: Patient Health Questionnaire 9-Item Version, Behavioral: iOTA | Intervention Type: BEHAVIORAL; Name: ScaleDown; Assigned to Arm(s): Arm 1: ScaleDown (only first 16 patients) | Intervention Type: BEHAVIORAL; Name: Enhanced Usual Care Packets; Assigned to Arm(s): Arm 1: ScaleDown (only first 16 patients), Arm 2: Enhanced Usual Care, Arm 3: iOTA | Intervention Type: OTHER; Name: 12-Item Short Form Health Survey; Assigned to Arm(s): Arm 1: ScaleDown (only first 16 patients), Arm 2: Enhanced Usual Care, Arm 3: iOTA | Intervention Type: OTHER; Name: International Physical Activity Questionnaire short form; Assigned to Arm(s): Arm 1: ScaleDown (only first 16 patients), Arm 2: Enhanced Usual Care, Arm 3: iOTA | Intervention Type: OTHER; Name: Multidimensional Body Self Relations Questionnaire - Appearance Subscales; Assigned to Arm(s): Arm 1: ScaleDown (only first 16 patients), Arm 2: Enhanced Usual Care, Arm 3: iOTA | Intervention Type: OTHER; Name: Cancer-Related Body Image Scale; Assigned to Arm(s): Arm 1: ScaleDown (only first 16 patients), Arm 2: Enhanced Usual Care, Arm 3: iOTA | Intervention Type: OTHER; Name: Patient Health Questionnaire 9-Item Version; Assigned to Arm(s): Arm 1: ScaleDown (only first 16 patients), Arm 2: Enhanced Usual Care, Arm 3: iOTA | Intervention Type: BEHAVIORAL; Name: iOTA; Assigned to Arm(s): Arm 3: iOTA

Answer: C