Please select the eligibility criteria that correspond to the clinical trial below.
Title: An 18-month Randomized Controlled Trial of a Low Glycemic Load Diet
Brief Summary: The primary aim of this study is to compare the effects of an experimental low-glycemic load diet with those of a conventional low-fat diet among obese young adults in an 18-month randomized-controlled trial.


Options:
A: Inclusion Criteria:

* Age 18 to 35 years
* Body mass index (BMI) ≥ 30 kg/m2
* Access to a working telephone
* Conversant in English
* Written medical clearance from a primary care physician or nurse practitioner, ruling out any pre-existing or complicating medical condition

Exclusion Criteria:

* Body weight \>300 lbs
* Major medical illness (heart, kidney or liver disease; diabetes; cancer; endocrinopathy; psychiatric illness) or other active medical problem
* An obesity-associated genetic syndrome (e.g., Prader-Willi)
* An abnormal screening laboratory test (ALT, creatinine, BUN, hematocrit)
* Fasting blood glucose ≥ 126 mg/dl)
* Taking any prescription medication that affects body weight (glucocorticoids, neuropsychiatric agents), blood pressure, or serum cholesterol concentrations
* Currently smoking (1 cigarette during any of the last 7 days)
* Previous diagnosis of an eating disorder (anorexia nervosa, bulimia, binge-eating disorder)
* If female, not pregnant or planning to become pregnant in the next 18 months and not lactating
* Failure to complete the pre-enrollment visits
B: Inclusion Criteria:

* Body Mass Index (BMI) between 25 and 40 kg/m2
* Physical examination and vital signs normal, or is considered abnormal, but clinically insignificant by researcher.
* In the case of individuals with chronic stable dose drug treatment and during the last 3 previous months at baseline, the investigator will assess their possible inclusion.

Exclusion Criteria:

* BMI less than 25 or higher than 40 kg/m2
* Pregnant women
* Breastfeeding period. If artificial feeding until 6 months after birth.
* Type 1 diabetes
* Severe kidney diseases
* Severe digestive system diseases
* Electrolyte disorders (disorders of sodium, potassium, calcium, chlorine, phosphorus, magnesium)
* Acute cardiovascular diseases
* Cancer
* Anemia
* Eating disorders
* Recent prescription drug treatment (without stable doses scheduled)
* Drug therapy that can influence weight loss as corticosteroids.
* Some type of cognitive impairment and / psychic
* Subjects in which poor collaboration or, in the investigator's opinion, have difficulty following the procedures of the study is foreseen
* Lack of commitment (at the discretion of the investigator) with the intervention, suspected non-compliance, or real difficulties to follow the development of the study.
C: Inclusion Criteria:

* Diabetes mellitus, Type 2.
* HgbA1c \> 6.0% at screening. This is to confirm the diabetes diagnosis.
* Aged 18 years old and older
* BMI 25 and above.

Exclusion Criteria:

* Condition that will make it difficult for participation. Such as:

  * cancer
  * liver failure
  * unstable coronary artery disease
  * severe emphysema
  * bulimia or strong history of bulimia
  * vegan
* Laboratory evidence of organ dysfunction

  * Abnormal kidney function (serum creatinine)
  * thyroid stimulating hormone out of normal range
* Previous use or new changes in medications that can interfere with the measures used in the study:

  * current use of insulin and no immediate plans to start or increase diabetic mediations.
  * more than 3 oral hypoglycemic medications.
  * use of systemic (oral or IV) corticosteroids in the 6 months prior
  * severe autoimmune disorders
  * initiation of psychiatric medications in past 2 months.
* Weight loss confounds

  * Current use of weight loss medications or supplements.
  * History of or planned weight loss surgery.
* Other

  * Pregnant or planning to get pregnant in the next year, breastfeeding, less than 6 months post-partum.
  * Unable or unwilling to do home glucose monitoring.
D: Inclusion Criteria:

* Men or women aged 22 - 75 years, any race/ethnicity
* BMI of 30 - 45 k/m2
* Willing and able to provide informed consent

Exclusion Criteria:

* History of self-reported clinical CVD (angina/myocardial infarction, coronary revascularization, heart failure, stroke/transient ischemic attack, peripheral arterial disease)
* Medical condition in which a low-carbohydrate diet may not be advised (diabetes, renal disease, cancer requiring treatment during the past year, osteoporosis, untreated thyroid disease, gout)
* Current use of more than 2 antihypertensive or more than 2 cholesterol-lowering medications
* For women, current pregnancy or breastfeeding or plans to become pregnant during the study period
* Consumption of more than 21 alcoholic beverages per week
* Currently on a diet or using prescription weight loss medications, underwent weight loss surgery, and/or experienced weight loss \>15 pounds within 6 months of study entry
* Plans to move out of the study area (\>1 hour from study site) or difficulty to come to the study site
* Participation of another household member in the study; employees or persons living with employees of the study
* Participation in other lifestyle intervention trials currently
* At the discretion of the study coordinator

Answer: A