Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Effect of Montelukast on the Airway Remodeling in Asthma Patients: Physiological-radiological Correlation
Brief Summary: The distal lung contributes to asthmatic airway remodeling which is observed from early onset of the disease. Cysteinyl leukotrienes (CysLT) play important role in the pathogenesis of airway remodeling and antileukotrienes work to exert a certain degree of anti-inflammatory effect. The cysteinyl leukotriene antagonist Montelukast has been in vivo shown to significantly inhibit ovalbumin induced airway smooth muscle hyperplasia and subepithelial fibrosis in sensitized mice. This study aims to evaluate if Montelukast could reverse airway remodeling in asthma patients by a non-invasive approach-HRCT.


Options:
A: Intervention Type: DRUG; Name: fluticasone propionate/salmeterol; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: fluticasone propionate; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: montelukast; Assigned to Arm(s): N/A
B: Arm Label: Placebo pill; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo | Arm Label: Singular pill; Type: EXPERIMENTAL; Interventions: Drug: singular | Intervention Type: DRUG; Name: singular; Assigned to Arm(s): Singular pill | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): Placebo pill
C: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: montelukast sodium | Intervention Type: DRUG; Name: montelukast sodium; Assigned to Arm(s): 1
D: Arm Label: Fluticasone Propionate/Salmeterol/Montelukast (FSC+MON); Type: ACTIVE_COMPARATOR; Interventions: Drug: fluticasone propionate/salmeterol (FSC), Drug: montelukast (MON), Drug: placebo nasal, Drug: ADVAIR DISKUS | Arm Label: Fluticasone Propionate/Salmeterol (FSC); Type: ACTIVE_COMPARATOR; Interventions: Drug: fluticasone propionate/salmeterol (FSC), Drug: placebo nasal, Drug: ADVAIR DISKUS, Drug: placebo capsule | Arm Label: Fluticasone Prop/Salmeterol/Flut Prop Nasal Spray (FSC+FPANS); Type: ACTIVE_COMPARATOR; Interventions: Drug: fluticasone propionate/salmeterol (FSC), Drug: fluticasone propionate (FP), Drug: ADVAIR DISKUS, Drug: placebo capsule | Arm Label: Montelukast (MON); Type: ACTIVE_COMPARATOR; Interventions: Drug: montelukast (MON), Drug: placebo nasal, Drug: placebo DISKUS | Intervention Type: DRUG; Name: fluticasone propionate/salmeterol (FSC); Assigned to Arm(s): Fluticasone Prop/Salmeterol/Flut Prop Nasal Spray (FSC+FPANS), Fluticasone Propionate/Salmeterol (FSC), Fluticasone Propionate/Salmeterol/Montelukast (FSC+MON) | Intervention Type: DRUG; Name: montelukast (MON); Assigned to Arm(s): Fluticasone Propionate/Salmeterol/Montelukast (FSC+MON), Montelukast (MON) | Intervention Type: DRUG; Name: fluticasone propionate (FP); Assigned to Arm(s): Fluticasone Prop/Salmeterol/Flut Prop Nasal Spray (FSC+FPANS) | Intervention Type: DRUG; Name: placebo nasal; Assigned to Arm(s): Fluticasone Propionate/Salmeterol (FSC), Fluticasone Propionate/Salmeterol/Montelukast (FSC+MON), Montelukast (MON) | Intervention Type: DRUG; Name: ADVAIR DISKUS; Assigned to Arm(s): Fluticasone Prop/Salmeterol/Flut Prop Nasal Spray (FSC+FPANS), Fluticasone Propionate/Salmeterol (FSC), Fluticasone Propionate/Salmeterol/Montelukast (FSC+MON) | Intervention Type: DRUG; Name: placebo capsule; Assigned to Arm(s): Fluticasone Prop/Salmeterol/Flut Prop Nasal Spray (FSC+FPANS), Fluticasone Propionate/Salmeterol (FSC) | Intervention Type: DRUG; Name: placebo DISKUS; Assigned to Arm(s): Montelukast (MON)

Answer: B