Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)
Brief Summary: This study is looking at the efficacy, durability, safety, and tolerability of multiple single doses of Ketamine vs. active placebo for treating patients with treatment resistant depression who are taking an antidepressant that is not working for them.


Options:
A: Arm Label: IV normal saline; Type: PLACEBO_COMPARATOR; Interventions: Drug: IV normal saline | Arm Label: IV GLYX-13; Type: EXPERIMENTAL; Interventions: Drug: GLYX-13 | Arm Label: SC GLYX-13; Type: EXPERIMENTAL; Interventions: Drug: GLYX-13 | Intervention Type: DRUG; Name: GLYX-13; Assigned to Arm(s): IV GLYX-13, SC GLYX-13 | Intervention Type: DRUG; Name: IV normal saline; Assigned to Arm(s): IV normal saline
B: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: AZD6765 | Arm Label: 2; Type: EXPERIMENTAL; Interventions: Drug: AZD6765 | Arm Label: 3; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: AZD6765; Assigned to Arm(s): 1, 2 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): 3
C: Arm Label: Part 1: Block A MK-8777; Type: EXPERIMENTAL; Interventions: Drug: MK-8777 | Arm Label: Part 1: Block A Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: Part 1: Block B MK-8777; Type: EXPERIMENTAL; Interventions: Drug: MK-8777 | Arm Label: Part 1: Block B Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: Part 1: Block C MK-8777; Type: EXPERIMENTAL; Interventions: Drug: MK-8777 | Arm Label: Part 1: Block C Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: Part 1: Block D MK-8777; Type: EXPERIMENTAL; Interventions: Drug: MK-8777 | Arm Label: Part 1: Block D Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: Part 2: MK-8777 200 mg; Type: EXPERIMENTAL; Interventions: Drug: MK-8777 | Arm Label: Part 2: MK-8777 800 mg; Type: EXPERIMENTAL; Interventions: Drug: MK-8777 | Arm Label: Part 2: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: MK-8777; Assigned to Arm(s): Part 1: Block A MK-8777, Part 1: Block B MK-8777, Part 1: Block C MK-8777, Part 1: Block D MK-8777, Part 2: MK-8777 200 mg, Part 2: MK-8777 800 mg | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Part 1: Block A Placebo, Part 1: Block B Placebo, Part 1: Block C Placebo, Part 1: Block D Placebo, Part 2: Placebo
D: Arm Label: Ketamine 0.1mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ketamine | Arm Label: Ketamine 0.2mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ketamine | Arm Label: Ketamine 0.5mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ketamine | Arm Label: Ketamine 1.0mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ketamine | Arm Label: Midazolam (Active Placebo); Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo Midazolam | Intervention Type: DRUG; Name: Ketamine; Assigned to Arm(s): Ketamine 0.1mg | Intervention Type: DRUG; Name: Ketamine; Assigned to Arm(s): Ketamine 0.2mg | Intervention Type: DRUG; Name: Ketamine; Assigned to Arm(s): Ketamine 0.5mg | Intervention Type: DRUG; Name: Ketamine; Assigned to Arm(s): Ketamine 1.0mg | Intervention Type: DRUG; Name: Placebo Midazolam; Assigned to Arm(s): Midazolam (Active Placebo)

Answer: D