Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Novel Treatment For Chronic Posttraumatic Stress Disorder (PTSD) Using Post-Reactivation Propranolol
Brief Summary: Objective: To use propranolol to treat established chronic post traumatic stress disorder (PTSD) by reducing reconsolidation of the reactivated trauma memory.

Hypothesis: A series of treatments with propranolol, in comparison to placebo, will produce a significant reduction in PTSD symptom severity in participants with chronic PTSD.

Study Design: This is a double-blind, placebo-controlled, randomized study. Methodology: Twenty-five participants per group with chronic PTSD will be recruited. On their first visit psychodiagnostic and psychometric evaluation will take place. In addition, script-preparation for the script-driven imagery procedure will occur. Following this, the participants will return each week for a period of 6 weeks to participate in the reactivation sessions with propranolol or placebo (participants assigned to the propranolol condition will receive propranolol throughout, and participants assigned to the placebo condition will receive placebo throughout). Two weeks later, the participants will return for a follow-up of the psychodiagnostic and psychometric evaluation, as well as psychophysiological assessment using script-driven imagery procedure.

Data Analysis: A two-factor analysis of variance (ANOVA) for repeated measures will be performed on study completers. The Drug factor will have two levels: propranolol and placebo. The Time factor will have two levels: pre-treatment and post-treatment. We predict a significant Drug x Time interaction, more precisely a greater decrease in PTSD severity in the propranolol than in the placebo group. The psychophysiological data will be contrasted to a normative cutoff score for PTSD.


Options:
A: Arm Label: Propranolol; Type: EXPERIMENTAL; Interventions: Drug: Propranolol is available in generic form as the Wyeth product under the trade name Inderal. | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Propranolol is available in generic form as the Wyeth product under the trade name Inderal. | Intervention Type: DRUG; Name: Propranolol is available in generic form as the Wyeth product under the trade name Inderal.; Assigned to Arm(s): Placebo, Propranolol
B: Arm Label: Ganaxolone; Type: EXPERIMENTAL; Interventions: Drug: Ganaxolone | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Ganaxolone; Assigned to Arm(s): Ganaxolone | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
C: Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Arm Label: GSK561679; Type: EXPERIMENTAL; Interventions: Drug: GSK561679 | Intervention Type: DRUG; Name: GSK561679; Assigned to Arm(s): GSK561679 | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
D: Arm Label: CBT no choice; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Cognitive behavioral therapy (CBT) | Arm Label: CBT choice; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Cognitive behavioral therapy (CBT) | Arm Label: sertraline no choice; Type: ACTIVE_COMPARATOR; Interventions: Drug: Sertraline | Arm Label: sertraline choice; Type: ACTIVE_COMPARATOR; Interventions: Drug: Sertraline | Intervention Type: DRUG; Name: Sertraline; Assigned to Arm(s): sertraline choice, sertraline no choice | Intervention Type: BEHAVIORAL; Name: Cognitive behavioral therapy (CBT); Assigned to Arm(s): CBT choice, CBT no choice

Answer: A