Please select the eligibility criteria that correspond to the clinical trial below.
Title: Enhancing Standard Cardiac Rehabilitation With Stress Management Training in Patients With Heart Disease
Brief Summary: The purpose of this study is to assess the extent to which combining exercise and stress management training (SMT) is more effective at improving biomarkers in vulnerable cardiac patients compared to exercise-based cardiac rehabilitation alone.


Options:
A: Inclusion Criteria:

* Age over 18 years
* STEMI (ST-elevated myocardial infarction) or non-STEMI
* Stable circulatory condition
* Numeric Rating Scale (NRS) (0-10): a score of at least 5 for "pain (during MI)" plus a score of at least 5 for "fear of dying (until admission to the CCU)" and/or "making sorrows and feeling helpless (when being told about having MI)"
* Written informed consent

Exclusion Criteria

* Participating in any other randomized-controlled trial run by the Cardiology Department of the University Hospital of Bern
* Emergency coronary artery bypass graft surgery
* Comorbid serious disease likely to cause death within 1 year
* Current clinically severe depression
* Not fully oriented to the situation, person, and place
* Cognitive impairment according to an adapted short version of the Mini-Mental State Examination
* Insufficient knowledge of German language in reading and understanding
* Affirmation of suicidal ideation in the last two weeks
B: Inclusion Criteria:

* Hospitalized for ACS defined as unstable angina or MI
* BDI greater or equal to 10 and \< 15 2-6 months post-ACS on each of 2 occasions, or BDI greater than 15 on one occasion
* Age at least 35 years
* Fluent in English or Spanish
* Able to complete baseline assessment within 2-6 months of index ACS event
* Able and willing to provide informed consent

Exclusion Criteria:

* Presence of non-cardiac condition likely to terminate fatally within 1 year
* Inaccessibility for intervention or follow-up (e.g., plans to move from the area)
* Cognitive impairment
* Need for immediate psychiatric intervention (i.e., requiring hospitalization or psychiatric intervention within 72 hours)
* Suicidal ideation
* Major psychiatric co-morbidity (current or by history) including active psychosis, bipolar disorder, or overt personality disorder
* Active substance abuse or dependency
* Chronic renal failure (receiving chronic dialysis treatment, or estimated glomerular filtration rate"...\[eGFR\] \< 30 ml/min/1.73 m2) or moderate/severe liver disease (e.g., esophageal varices, portal hypertension, encephalopathy, GI bleeding)
* Participation in another clinical trial for the treatment of depression.
C: Inclusion Criteria:

* Patients younger than 75 years with a recent acute MI (\< 3 months)
* Depression and/or anxiety score of \> 7 on one or both of the HADS subscales (concerns only the intervention, not the reference group)

Exclusion Criteria:

* Patients that are scheduled for a coronary artery bypass surgery (CABG)
* Unable or unwilling to use computer or Internet
* Difficulties in reading or understanding Swedish
* A life expectancy of less than a year
* Anticipated poor compliance (multi-disease, substance abuse etc.)
* Highly depressed or suicidal (MADRS-score \> 29 or MADRS item 9 \> 3)
D: Inclusion Criteria:

* Diagnosis of Coronary Heart Disease (CHD)
* Eligibility for Cardiac Rehabilitation (CR) in North Carolina
* Capacity to give informed consent and follow study procedures

Exclusion Criteria:

* Received heart transplant
* LVEF \< 30%
* Labile ECG changes prior to testing
* Currently using a pacemaker
* Resting BP \> 200/120 mm Hg
* Left main disease \> 50%
* Unable to comply with assessment procedures
* Unwilling or unable to be randomized to treatment groups
* Primary diagnosis of the following psychiatric disorders: schizophrenia, dementia, current delirium, or other psychotic disorder
* Current alcohol or substance abuse disorder
* Acute suicide risk
* Actively undergoing ongoing psychiatric treatment

Answer: D