Please select the eligibility criteria that correspond to the clinical trial below.
Title: Intensive Diet and Exercise for Arthritis
Brief Summary: The purpose of this study is to compare the effects of a calorie-restricting diet, exercise, and a combination of both in reducing knee inflammation and compressive forces in obese and overweight adults with knee osteoarthritis (OA).


Options:
A: Inclusion Criteria:- Provision of informed consent to participate.

* Women with over 18 years old,with chronic pain because of primary osteoarthritis of the knee.
* Pain stable for at least three months. Score greater than or equal to 3 cm (0 cm = "no pain" and "worst possible pain" = 10cm) on Visual Analog Scale (VAS) for pain perception at baseline.
* No contraindications to electroacupuncture, transcranial direct current stimulation or transcranial magnetic stimulation.

Exclusion Criteria:-Clinically significant or unstable disorder, medical or psychiatric.

* Presence of neurological or rheumatic comorbidity.
* Pregnancy.
* Already having been treated with acupuncture.
* Having performed with corticosteroid infiltration in the last six weeks or are using this.
* Having performed with hyaluronic acid infiltration in the last year.
* Previous surgery on the limb to be treated or have surgical program for the next 6 months.
B: Inclusion Criteria:

* • Female subjects aged 60 years and over, non-obese (BMI between 18.5 and 24.9 kg / m2), with diagnosis of knee OA according to the criteria of the American College of Rheumatology (Altman et al. , 1986), which are: knee pain most of the day during the last weeks and age greater than 60 years (mandatory criteria), and at least two of the following criteria: stiffness after rest less than 30 minutes, crackle in the affected knee , joint increase of firm consistency, absence of temperature increase and painful hypersensitivity to palpation;

  * Individuals with radiographic signs of degeneration of the knee joint;
  * Individuals with any degree of degeneration according to the Kellgren-Lawrence scale;
  * Individuals with a pain scale above 3 according to NPRS;
  * Stiffness in the knee for at least 6 months prior to screening;
  * Stiffness during the beginning of activities;
  * Intermittent swelling;
  * Never have used KT;
  * Individuals with no history of associated joint disease or systemic rheumatic disease and / or history of surgery in the affected lower limb;
  * Individuals who are not under physiotherapeutic treatment during the intervention;
  * Individuals without neurological, vestibular, visual or auditory deficits that make evaluations impossible.

Exclusion Criteria:

* • Individuals who report pain during the procedure;

  * Individuals who do not complete the treatment time or who do not perform the evaluation procedures correctly, making it impossible to collect any of the data investigated;
  * Individuals with allergy to bandage or cutaneous injury in the region where KT will be applied;
  * Individuals who present hypertensive peak during the evaluations.
C: Inclusion Criteria:

* Grade II to III radiographic tibiofemoral OA of one or both knees
* Body mass index (BMI) of 27 to 37
* Sedentary lifestyle, defined as not participating in more than 30 minutes of formal exercise per week within the 6 months prior to study entry

Exclusion Criteria:

* Significant comorbidity that may pose a safety risk to the participant or otherwise interfere with the study. More information about this criterion can be found in the protocol.
* Previous acute knee injury
* Knee injection within 1 month of study entry
* Knee surgery within 6 months of study entry
* Knee OA other than tibiofemoral OA
* Unwilling or unable to change eating and physical activity habits due to environment
* Cannot speak or read English
* Excess alcohol use (21 or more drinks per week)
* Unable to finish the 18-month study or unlikely to comply with the study
* Unable to undergo MRI of the knee
* Significant cognitive impairment
D: Inclusion Criteria:

* English speaking adults (\>18 years of age)
* Provided with a diagnosis of knee OA by a physician
* Self-report of having experienced pain and disability related to knee OA for at least 6 months.

Exclusion Criteria:

* Skin conditions in which application of phototherapy may be contra-indicated (skin cancer, people receiving radiation therapy)
* History of total joint arthroplasty of the affected knee
* Red flags suggestive of non-musculoskeletal etiology (i.e. fever/chills, unrelenting night pain, multi-segmental or bilateral loss of sensation, sudden unexplained weight loss).

Answer: C