Please select the eligibility criteria that correspond to the clinical trial below.
Title: D-cycloserine Adjunctive Treatment for PTSD in Adolescents
Brief Summary: The purpose of this study is to show whether D-cycloserine in combination with cognitive behavioral therapy (CBT) is more effective than CBT plus placebo to reduce symptoms of posttraumatic stress disorder (PTSD) in 13-18 year-old children.


Options:
A: Inclusion Criteria:

* Certain number of PTSD symptoms plus functional impairment
* Must be able to swallow pills

Exclusion Criteria:

* Serious kidney or liver disease
* Epilepsy
* Bipolar disorder
* Psychosis
B: Inclusion Criteria:

* The child must receive a principal diagnosis of OCD at Baseline, based on DSM-IV criteria. This diagnosis will be derived from the Anxiety Disorder Interview Schedule for DSM-IV-Child Interview Schedule - Parent version (ADIS-IV-P), and must reflect a clinical severity rating of 4 or above
* CY-BOCS Total Score ≥ 16
* Be between the ages of 8 and 17 years
* Score ≥ 80 on the Peabody Picture Vocabulary Test-3rd Edition (Dunn \& Dunn, 1997)
* At least one parent available to accompany the child to all sessions;
* English speaking.

Exclusion Criteria:

* Psychosis, pervasive developmental disorder, bipolar disorder, or current suicidal intent measured by the ADIS-IV-P and all available clinical information
* Principal diagnosis other than OCD
* Youth with mental rituals, incompleteness, or hoarding symptoms as E/RP exercises would be more difficult to conduct/monitor than those with overt rituals
* Unavailability of at least one caregiver to participate in the treatment
* Refusal of parent to accept random assignment to treatment condition
* A positive diagnosis in the caregiver of mental retardation, psychosis, clinically significant tics, or other psychiatric disorders or conditions that would limit their ability to understand E/RP (based on clinical interview)
* Weight less than 25.0 kg or greater than 80.0kg
* Epilepsy, renal insufficiency, and current or past history of alcohol abuse (DCS is contraindicated for such conditions)
* Pregnant or having unprotected sex \[in females\] as the effects of DCS on pregnant youth are unknown
* General poor physical health as determined by medical physical and laboratory tests.
C: Inclusion Criteria:

1. Diagnosis of OEF-OIF (Operations Enduring Freedom or Iraqi Freedom) Combat Related PTSD;
2. Female participants of childbearing potential must agree to use an effective method of birth control (i.e., oral contraceptive, Norplant, diaphragm, condom, or spermicide) during the course of the study, or to remain abstinent from sex, to ensure they do not become pregnant during the course of the study;
3. Ability to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments;
4. Participants must be literate in English;
5. Patients must be medically healthy and willing to take the study drug;
6. VRE stimuli available must be consistent with subject's trauma.

Exclusion Criteria:

1. Lifetime or current diagnosis of schizophrenia or other psychotic disorder, bipolar disorder;
2. Participation in a clinical trial during the previous 3 months;
3. Current evidence or history of significant unstable medical illness or organic brain impairment, including stroke, CNS tumor, demyelinating disease, cardiac, pulmonary, gastrointestinal, renal or hepatic impairment;
4. Patients who in the investigator's judgment pose a current suicidal or homicidal risk;
5. Alcohol, medication, or illegal substance dependence within the past 90 days;
6. Treatment with any other concomitant medication with primarily CNS activity, or treatment with any medication that the PI judges not acceptable for this study;
7. history of seizures;
8. Pregnancy or lactation.
D: Inclusion Criteria:

* Certain number of PTSD symptoms plus functional impairment
* Must be able to swallow pills

Exclusion Criteria:

* Serious kidney or liver disease
* Epilepsy
* Bipolar
* Psychosis

Answer: A