Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: RANDOMISED TRIAL OF ADJUVANT CHEMOTHERAPY WITH HIGH-DOSE DOXORUBICIN, IFOSFAMIDE AND LENOGRASTIM IN HIGH GRADE SOFT TISSUE SARCOMA
Brief Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether giving chemotherapy after surgery is more effective than surgery alone in treating soft tissue sarcoma.

PURPOSE: Randomized phase III trial to compare the effectiveness of surgery with or without chemotherapy in treating patients who have soft tissue sarcoma.


Options:
A: Arm Label: Group 1; Type: EXPERIMENTAL; Interventions: Biological: dactinomycin, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: ifosfamide, Drug: vincristine sulfate, Procedure: conventional surgery, Radiation: radiation therapy | Arm Label: Group 2, arm I; Type: EXPERIMENTAL; Interventions: Biological: dactinomycin, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: ifosfamide, Drug: vincristine sulfate, Procedure: conventional surgery, Radiation: radiation therapy | Arm Label: Group 2, arm II; Type: EXPERIMENTAL; Interventions: Biological: dactinomycin, Drug: busulfan, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: ifosfamide, Drug: melphalan, Drug: vincristine sulfate, Procedure: autologous hematopoietic stem cell transplantation, Procedure: conventional surgery, Radiation: radiation therapy | Intervention Type: BIOLOGICAL; Name: dactinomycin; Assigned to Arm(s): Group 1, Group 2, arm I, Group 2, arm II | Intervention Type: DRUG; Name: busulfan; Assigned to Arm(s): Group 2, arm II | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): Group 1, Group 2, arm I, Group 2, arm II | Intervention Type: DRUG; Name: etoposide; Assigned to Arm(s): Group 1, Group 2, arm I, Group 2, arm II | Intervention Type: DRUG; Name: ifosfamide; Assigned to Arm(s): Group 1, Group 2, arm I, Group 2, arm II | Intervention Type: DRUG; Name: melphalan; Assigned to Arm(s): Group 2, arm II | Intervention Type: DRUG; Name: vincristine sulfate; Assigned to Arm(s): Group 1, Group 2, arm I, Group 2, arm II | Intervention Type: PROCEDURE; Name: autologous hematopoietic stem cell transplantation; Assigned to Arm(s): Group 2, arm II | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): Group 1, Group 2, arm I, Group 2, arm II | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): Group 1, Group 2, arm I, Group 2, arm II
B: Arm Label: Regimen A; Type: EXPERIMENTAL; Interventions: Biological: filgrastim, Drug: cyclophosphamide, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: ifosfamide, Drug: vincristine sulfate, Procedure: adjuvant therapy, Procedure: conventional surgery, Procedure: neoadjuvant therapy, Radiation: brachytherapy, Radiation: radiation therapy | Arm Label: Regimen B; Type: EXPERIMENTAL; Interventions: Biological: filgrastim, Drug: cyclophosphamide, Drug: doxorubicin hydrochloride, Drug: etoposide, Drug: ifosfamide, Drug: vincristine sulfate, Procedure: adjuvant therapy, Procedure: conventional surgery, Procedure: neoadjuvant therapy, Radiation: brachytherapy, Radiation: radiation therapy | Intervention Type: BIOLOGICAL; Name: filgrastim; Assigned to Arm(s): Regimen A, Regimen B | Intervention Type: DRUG; Name: cyclophosphamide; Assigned to Arm(s): Regimen A, Regimen B | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): Regimen A, Regimen B | Intervention Type: DRUG; Name: etoposide; Assigned to Arm(s): Regimen A, Regimen B | Intervention Type: DRUG; Name: ifosfamide; Assigned to Arm(s): Regimen A, Regimen B | Intervention Type: DRUG; Name: vincristine sulfate; Assigned to Arm(s): Regimen A, Regimen B | Intervention Type: PROCEDURE; Name: adjuvant therapy; Assigned to Arm(s): Regimen A, Regimen B | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): Regimen A, Regimen B | Intervention Type: PROCEDURE; Name: neoadjuvant therapy; Assigned to Arm(s): Regimen A, Regimen B | Intervention Type: RADIATION; Name: brachytherapy; Assigned to Arm(s): Regimen A, Regimen B | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): Regimen A, Regimen B
C: Arm Label: Trabectedin; Type: EXPERIMENTAL; Interventions: Drug: Trabectedin | Arm Label: Dacarbazine; Type: ACTIVE_COMPARATOR; Interventions: Drug: Dacarbazine | Intervention Type: DRUG; Name: Trabectedin; Assigned to Arm(s): Trabectedin | Intervention Type: DRUG; Name: Dacarbazine; Assigned to Arm(s): Dacarbazine
D: Intervention Type: BIOLOGICAL; Name: filgrastim; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: doxorubicin hydrochloride; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: ifosfamide; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: isolated perfusion; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: adjuvant therapy; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): N/A | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): N/A

Answer: D