Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Effects and Mechanisms of Intensive Robot-Assisted Therapy in Patients With Subacute Stroke: Outcomes in Brain/Movement Reorganization, Sensorimotor and Daily Functions, and Physiological Markers.
Brief Summary: Robot-assisted training (RT) devices developed to date have a significant impact on stroke rehabilitation. Several research groups have developed the robotic devices and examined their efficacy on improving upper limb function after stroke. All these robotic devices have been applied in stroke rehabilitation and their efficacy are evaluated, but the scientific evidence for the mechanisms of RT-induced recovery, the optimal treatment intensity, and the impact on physiological responses is still lacking.

This trial is to examine (1) the immediate effects of treatment intensity in RT on sensorimotor impairments and functional performance in patients with subacute stroke; (2) the long-term benefits of treatment intensity in RT by conducting a 6-month follow up evaluation; and (3) the effects of RT on cortical/movement reorganization as well as on the physiological markers of inflammation, oxidative stress, and erythrocyte deformability. These overall findings will help better understanding of the efficacy of RT on functional outcomes, brain and movement reorganization, and physiological markers.


Options:
A: Arm Label: Higher-intensity RT group; Type: EXPERIMENTAL; Interventions: Device: RT, Behavioral: Conventional rehabilitation (CR) | Arm Label: Lower-intensity RT group; Type: EXPERIMENTAL; Interventions: Device: RT, Behavioral: Conventional rehabilitation (CR) | Arm Label: Conventional rehabilitation (CR) group; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Conventional rehabilitation (CR) | Intervention Type: DEVICE; Name: RT; Assigned to Arm(s): Higher-intensity RT group, Lower-intensity RT group | Intervention Type: BEHAVIORAL; Name: Conventional rehabilitation (CR); Assigned to Arm(s): Conventional rehabilitation (CR) group, Higher-intensity RT group, Lower-intensity RT group
B: Arm Label: Mirror therapy with tDCS; Type: EXPERIMENTAL; Interventions: Behavioral: Mirror Therapy with tDCS | Arm Label: Mirror Therapy; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Mirror Therapy | Arm Label: Control Intervention; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Control Intervention | Arm Label: Mirror Therapy with sham-tDCS; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Mirror Therapy with sham-tDCS | Intervention Type: BEHAVIORAL; Name: Mirror Therapy with tDCS; Assigned to Arm(s): Mirror therapy with tDCS | Intervention Type: BEHAVIORAL; Name: Mirror Therapy with sham-tDCS; Assigned to Arm(s): Mirror Therapy with sham-tDCS | Intervention Type: BEHAVIORAL; Name: Mirror Therapy; Assigned to Arm(s): Mirror Therapy | Intervention Type: BEHAVIORAL; Name: Control Intervention; Assigned to Arm(s): Control Intervention
C: Intervention Type: OTHER; Name: Visumotor Upper Extremity Training; Assigned to Arm(s): N/A | Intervention Type: OTHER; Name: Anodal/Sham tDCS; Assigned to Arm(s): N/A
D: Arm Label: Device-assisted therapy; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Device-assisted therapy | Arm Label: Therapy-based occupational therapy; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Therapy-based occupational therapy | Intervention Type: BEHAVIORAL; Name: Device-assisted therapy; Assigned to Arm(s): Device-assisted therapy | Intervention Type: BEHAVIORAL; Name: Therapy-based occupational therapy; Assigned to Arm(s): Therapy-based occupational therapy

Answer: A