TrialPanorama/Dataset huggingface dataset:
Please select the outcome measures that correspond to the clinical trial below.
Title: Effectiveness of Cognitive-Behavioral Therapy for Children With High-Functioning Autism Spectrum Disorder and Anxiety
Brief Summary: Many children and adolescents with autism spectrum disorder (ASD) experience high levels of anxiety which can further inhibit their ability to master developmental tasks such as succeeding in school and developing and maintaining friendships. Despite the need for effective treatments for children with ASD and anxiety, there have been few studies that have addressed this issue. Recently, preliminary evidence has supported the use of cognitive-behavioral therapy (CBT) to treat anxiety disorders in children with ASD.

This study will utilize a CBT treatment program called Coping Cat. Coping Cat has been found to be one of the most effective treatments for typically developing children with anxiety and has also been shown to be effective for treating anxiety in children with other disorders such as physical impairments, selective mutism, and Attention Deficit Hyperactivity Disorder. The investigators goal is to demonstrate that Coping Cat is an effective treatment for children with ASD and anxiety. Finding effective treatments for children with ASD and anxiety could increase adaptive social relationships, decrease stress among families, and prevent the maintenance of anxiety into adulthood.


Options:
A: Score on anxiety diagnostic interview after treatment or waitlist (post-treatment); Score on anxiety rating scale after treatment or waitlist (post-treatment)
B: Anxiety Disorders Interview Schedule - Child/Parent Version (Post Treatment (16 weeks))
C: Pediatric Anxiety Rating Scale (After an average of 16 weeks (Post-treatment))
D: N/A

Answer: B
Please select the outcome measures that correspond to the clinical trial below.
Title: Comparison of Adaptive Servo Ventilation(Bipap® Auto SV Advanced) and Oxgen Therapy in Chronic Heart Failure Patients Complicated With Central Sleep Apnea
Brief Summary: The aim of this study is to compare the effects of Adaptive Servo Ventilation (Bipap® auto SV Advanced) and oxygen therapy in chronic heart failure patients complicated with central sleep apnea.


Options:
A: All Cause Mortality or Unplanned Hospitalisation/Prolongation of Hospitalisation for Worsening Heart Failure (time to first event, assessed for up to 70 weeks); Cardiovascular Mortality or Unplanned Hospitalisation/Prolongation of Hospitalisation for Worsening Heart Failure (time to first event, assessed for up to 70 weeks); All Cause Mortality or All Cause Unplanned Hospitalisation/Prolongation of Hospitalisation (time to first event, assessed for up to 70 weeks)
B: Left ventricular ejection fraction confirmed by echocardiography (three months)
C: apnea-hypopnea index (at 6 weeks)
D: Global Rank Endpoint (Baseline, 6 months)

Answer: B
Please select the outcome measures that correspond to the clinical trial below.
Title: Comparison of Adaptive Servo Ventilation(Bipap® Auto SV Advanced) and Oxgen Therapy in Chronic Heart Failure Patients Complicated With Central Sleep Apnea
Brief Summary: The aim of this study is to compare the effects of Adaptive Servo Ventilation (Bipap® auto SV Advanced) and oxygen therapy in chronic heart failure patients complicated with central sleep apnea.


Options:
A: Global Rank Endpoint (Baseline, 6 months)
B: improvement of isovolumetric relaxation time (30 minutes)
C: Left ventricular ejection fraction confirmed by echocardiography (three months)
D: All Cause Mortality or Unplanned Hospitalisation/Prolongation of Hospitalisation for Worsening Heart Failure (time to first event, assessed for up to 70 weeks); Cardiovascular Mortality or Unplanned Hospitalisation/Prolongation of Hospitalisation for Worsening Heart Failure (time to first event, assessed for up to 70 weeks); All Cause Mortality or All Cause Unplanned Hospitalisation/Prolongation of Hospitalisation (time to first event, assessed for up to 70 weeks)

Answer: C
Please select the outcome measures that correspond to the clinical trial below.
Title: Can Motivational Interviewing be Effective for Smoking Cessation?
Brief Summary: The purpose of this study is to determine, among a sample of general adult smokers, the effectiveness of three different counseling interventions for motivating quit attempts among smokers not yet ready to quit.


Options:
A: A Serious Quit Attempt in Which the Participant Intends to Permanently Stop Smoking (From study enrollment through six month follow-up); A 24 Hour Serious Quit Attempt in Which the Participant Intends to Permanently Stop Smoking (From study enrollment through six month follow-up)
B: Breath carbon monoxide (Throughout study - one year)
C: 7-day point prevalence abstinence from smoking (6 months after enrollment)
D: Quit Attempt(s) (Any time within 26 weeks)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Can Motivational Interviewing be Effective for Smoking Cessation?
Brief Summary: The purpose of this study is to determine, among a sample of general adult smokers, the effectiveness of three different counseling interventions for motivating quit attempts among smokers not yet ready to quit.


Options:
A: Quit Attempt(s) (Any time within 26 weeks)
B: 7-day Point Prevalence Abstinence From Cigarettes (24 months)
C: smoking abstinence: self reported abstinence (12 or more months) (12 months)
D: Tobacco Abstinence (3 months)

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: Can Motivational Interviewing be Effective for Smoking Cessation?
Brief Summary: The purpose of this study is to determine, among a sample of general adult smokers, the effectiveness of three different counseling interventions for motivating quit attempts among smokers not yet ready to quit.


Options:
A: smoking cessation (6-months)
B: Smoking abstinence (2 years)
C: Quit Attempt(s) (Any time within 26 weeks)
D: Point prevalence abstinence

Answer: C
Please select the outcome measures that correspond to the clinical trial below.
Title: The Personal Health Care Partner Project, Conversational IT for Better, Safer Pediatric Primary Care
Brief Summary: Interactive telephony technologies offer a potentially highly effective, patient-centered communication modality by guiding parents at home through interactive discussions that can gather information and actively reinforce recommendations and treatments. Interactive telephony systems are particularly well suited for use in vulnerable populations since access to the telephone is nearly universal, and the system does not rely on reading printed text. The investigators propose to develop and evaluate an integrated patient-centered health information system, the Personal Health Partner (PHP). The PHP will use fully automated, interactive, conversations to gather personal health data and counsel parents before scheduled visits, exchange that data with the child's primary care clinician via the electronic health record (EHR), and offer personalized follow-up assessment and counseling after visits. The information technology-based approach to be evaluated in this project will link parents and children outside the clinical setting with their primary care center and will offer comprehensive assessments AND counseling to reinforce and support parental behavior change.


Options:
A: completing CRC screening test (1 and 6 months post education)
B: Personal Health Partner (PHP) assessment with electronic health record (EHR) data exchange before pediatric primary care visits (2 week -1day before doctor's appointment and 1 week after appointment)
C: Percentage of participants with controlled blood pressure, as defined by the following criteria: less than 130/80 mm Hg for participants with diabetes or chronic kidney disease; less than 140/90 mm Hg for all other participants (Measured at Year 1)
D: The primary outcome is improvement in the overall composite of all metrics eligible for intervention regardless of their selection as targets. (12 months)

Answer: B
Please select the outcome measures that correspond to the clinical trial below.
Title: The Personal Health Care Partner Project, Conversational IT for Better, Safer Pediatric Primary Care
Brief Summary: Interactive telephony technologies offer a potentially highly effective, patient-centered communication modality by guiding parents at home through interactive discussions that can gather information and actively reinforce recommendations and treatments. Interactive telephony systems are particularly well suited for use in vulnerable populations since access to the telephone is nearly universal, and the system does not rely on reading printed text. The investigators propose to develop and evaluate an integrated patient-centered health information system, the Personal Health Partner (PHP). The PHP will use fully automated, interactive, conversations to gather personal health data and counsel parents before scheduled visits, exchange that data with the child's primary care clinician via the electronic health record (EHR), and offer personalized follow-up assessment and counseling after visits. The information technology-based approach to be evaluated in this project will link parents and children outside the clinical setting with their primary care center and will offer comprehensive assessments AND counseling to reinforce and support parental behavior change.


Options:
A: Personal Health Partner (PHP) assessment with electronic health record (EHR) data exchange before pediatric primary care visits (2 week -1day before doctor's appointment and 1 week after appointment)
B: Change in body mass index (BMI) (Measured at Year 2)
C: Weight (Measured at Month 24)
D: Changes in Diabetes Self-management Behaviors as Measured by Summary of Diabetes Self-Care Activities (SDSCA) Scale (Baseline and 1 year); Changes in Minutes of Moderate Physical Activity (Baseline and 1 year); Changes in Minutes of Vigorous Exercise (Baseline and 1 year)

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: A Multi-center, Placebo-Controlled, Dose Ranging Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Following Oral Administration of PSI-7977 in Combination With Pegylated Interferon and Ribavirin in Treatment-Naïve Patients With Chronic HCV Infection Genotype 1, and an Open Label Assessment of PSI-7977 in Patients With HCV Genotypes 2 or 3
Brief Summary: Genotype 1: Participants with genotype 1 hepatitis C (HCV) infection were randomized to receive sofosbuvir (GS-7977; PSI-7977) 200 mg or 400 mg, or matching placebo, plus pegylated interferon alfa 2a (PEG) and ribavirin (RBV) for 12 weeks, followed by PEG+RBV for an up to an additional 36 weeks. Randomization was stratified by IL28B status (CC, CT, TT) and HCV RNA level (\< 800,000 IU/ml or ≥ 800,000 IU/ml) at baseline. Participants were randomized in a 2:2:1 manner; those who achieved an extended rapid virologic response (eRVR) (HCV RNA \< lower limit of detection \[15 IU/mL\] from Weeks 4 through 12) received an additional 12 weeks of PEG+RBV. Subjects not achieving eRVR received an additional 36 weeks of PEG+RBV.

Genotype 2 and 3: Participants with genotype 2 or 3 hepatitis C (HCV) received sofosbuvir 400 mg plus PEG+RBV for 12 weeks.


Options:
A: Proportion of treated subjects in each of the naive arms with sustained virologic response (SVR12) (Post treatment 12 week)
B: Percentage of Subjects With Undetectable Plasma Hepatitis C Virus (HCV) Ribonucleic Acid (RNA) at Week 24 After the Completion of Study Drug Dosing (24 weeks after the completion of study drug dosing (up to Week 72))
C: Percentage of Participants With Sustained Virologic Response at Post Treatment Week 12 (SVR12) (Follow-up Week 12)
D: Percentage of Participants Who Experienced Adverse Events During the Sofosbuvir Treatment Period (Baseline to Week 12 plus 30 days)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Lipoic Acid for Neuroprotection in Secondary Progressive MS
Brief Summary: The purpose of the study is to determine if lipoic acid can protect the brain and slow disability in secondary progressive multiple sclerosis.


Options:
A: MRI disease activity measured by the number of new T1-enhancing lesions during the six months of treatment.; MRI disease activity measured by the number of new T1-hypo-intensive lesions (black holes) after 24 months of treatment.
B: Brain Atrophy by MRI (% change brain volume from baseline to year 2)
C: Fasting and postprandial lipid oxidation in grams per hour, assessed by indirect calorimetry, after 3 months intake of green tea extract versus placebo (Three months)
D: Annualized Relapse Rate (ARR) in Participants With Relapsing Multiple Sclerosis (MS) at 96 Weeks In Double Blind Period (Week 96)

Answer: B
Please select the outcome measures that correspond to the clinical trial below.
Title: High Flow Nasal Cannula Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome: a Randomized, Controlled, Prospective Study
Brief Summary: The investigators hypothesize that while the extremely low birthweight (ELBW) infants (\<1000 g) may need NIMV for the treatment of RDS, larger infants or the smaller ones post extubation may enjoy the comfort benefits associated with HFNC while getting coparable respiratory support to NIMV.


Options:
A: combined rate of mortality and neurodevelopmental disability in survivors at a corrected age of 18 months. (corrected age of 18 months)
B: The percent of infants who will fail NRS and need endotracheal ventilation or will be switched to another mode of NRS. (1 year)
C: The rate of successful extubation with either mode of NCPAP (Day 7 post primary extubation)
D: Composite of survival to 36 weeks gestational age, free of moderate-severe bronchopulmonary dysplasia (36 weeks gestational age)

Answer: B
Please select the outcome measures that correspond to the clinical trial below.
Title: High Flow Nasal Cannula Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome: a Randomized, Controlled, Prospective Study
Brief Summary: The investigators hypothesize that while the extremely low birthweight (ELBW) infants (\<1000 g) may need NIMV for the treatment of RDS, larger infants or the smaller ones post extubation may enjoy the comfort benefits associated with HFNC while getting coparable respiratory support to NIMV.


Options:
A: Duration of NIV Support (10 days); Failure of NIV Support (10 days)
B: Incidence of Mechanical Ventilation via endotracheal tube after non-invasive respiratory support. (At 7 days after non-invasive respiratorynsupport.)
C: Need for Endotracheal Ventilation in the First 72 hs of Life (first 72 hs of life); Mechanical Ventilation Within the First 72h of Life in the Two Study Groups.(NIPPV vs NCPAP) (first 3 days of life(72hours))
D: The percent of infants who will fail NRS and need endotracheal ventilation or will be switched to another mode of NRS. (1 year)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: High Flow Nasal Cannula Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome: a Randomized, Controlled, Prospective Study
Brief Summary: The investigators hypothesize that while the extremely low birthweight (ELBW) infants (\<1000 g) may need NIMV for the treatment of RDS, larger infants or the smaller ones post extubation may enjoy the comfort benefits associated with HFNC while getting coparable respiratory support to NIMV.


Options:
A: The percent of infants who will fail NRS and need endotracheal ventilation or will be switched to another mode of NRS. (1 year)
B: Duration of oxygen use (3 months)
C: Patient comfort (EDIN score) (48 h (CPAP 24 h and HFNC 24 h); cumulative EDIN score for each 24 epoch is calculated and a change between the two interventions are assessed)
D: Compare extubation success rate, defined as % infants remaining extubated for > 72 hrs, among infants managed with HHFNC versus nCPAP (72 hrs)

Answer: A
Please select the outcome measures that correspond to the clinical trial below.
Title: High Flow Nasal Cannula Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome: a Randomized, Controlled, Prospective Study
Brief Summary: The investigators hypothesize that while the extremely low birthweight (ELBW) infants (\<1000 g) may need NIMV for the treatment of RDS, larger infants or the smaller ones post extubation may enjoy the comfort benefits associated with HFNC while getting coparable respiratory support to NIMV.


Options:
A: Patient comfort (EDIN score) (48 h (CPAP 24 h and HFNC 24 h); cumulative EDIN score for each 24 epoch is calculated and a change between the two interventions are assessed)
B: Compare extubation success rate, defined as % infants remaining extubated for > 72 hrs, among infants managed with HHFNC versus nCPAP (72 hrs)
C: Death or Chronic Lung Disease (at 36 weeks postmenstrual age); Death (36 weeks adjusted age)
D: The percent of infants who will fail NRS and need endotracheal ventilation or will be switched to another mode of NRS. (1 year)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Ultrasound Guidance for Radial Arterial Blood Sampling
Brief Summary: The investigators aim to determine if ultrasound guidance results in improved technique when drawing blood via a radial artery puncture.


Options:
A: Success rate of arterial or femoral catheter placement (1 day)
B: success rate of radial artery cathertrization (postoperate 72 hours)
C: Is only one puncture attempt necessary to attain the radial artery? yes/no (maximum two hours)
D: Quick Disabilities of the Arm Shoulder and Hand (DASH) Questionnaire Score (0-100) (1 year); Thumb and Forefinger Pinch Strength Test (1 year); Hand Grip Strength Test (1 month)

Answer: C
Please select the outcome measures that correspond to the clinical trial below.
Title: Ultrasound Guidance for Radial Arterial Blood Sampling
Brief Summary: The investigators aim to determine if ultrasound guidance results in improved technique when drawing blood via a radial artery puncture.


Options:
A: Successful rate without extra vascular damage (Through study completion, an average of 1 year.)
B: success rate of radial artery cathertrization (postoperate 72 hours)
C: Is only one puncture attempt necessary to attain the radial artery? yes/no (maximum two hours)
D: Arterial catheterization time (Interval between contact of the ultrasound transducer with the skin and confirmation of an arterial waveform on the monitor, an expected average of 200 seconds)

Answer: C
Please select the outcome measures that correspond to the clinical trial below.
Title: Ultrasound Guidance for Radial Arterial Blood Sampling
Brief Summary: The investigators aim to determine if ultrasound guidance results in improved technique when drawing blood via a radial artery puncture.


Options:
A: First Pass Success When Attempting Arterial Catheterization. (Immediate, upon study entry)
B: The proportion of patients who only needs one puncture attempt in order to successfully extract enough blood to make an arterial blood gas analysis (up to 1 hour after arterial puncture)
C: Time Needed to Correctly Insert the Arterial or Midline Catheter. (Immediately following intervention (within 2 hours))
D: Is only one puncture attempt necessary to attain the radial artery? yes/no (maximum two hours)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Preoperative Single-dose Steroid Application for the Treatment of Nausea and Vomiting After Thyroid Surgery
Brief Summary: The study is to compare the postoperative recovery, as determined by postoperative nausea and vomiting (PONV) after preoperative application of single-dose dexamethasone versus saline in patients undergoing partial or total thyroidectomy.


Options:
A: • Proportion of patients with Complete Response (no nausea, no vomiting, no retching, and no use of rescue medication) during the first 24 hours after surgery (1-24 hours post-operatively)
B: Incidence of Postoperative Nausea and Vomiting (postoperative 24 hours)
C: Cumulative 24 Hour Oral Morphine Equivalent Consumption (24 hours (Day 1))
D: Incidence of Postoperative Nausea and Vomiting (within 48 hours after surgery)

Answer: D
Please select the outcome measures that correspond to the clinical trial below.
Title: Effect of Internet, Mobil Applications and SMS-based Encouragements to Intensive Exercise in Adolescents With Congenital Heart Disease
Brief Summary: All over the world 0.8 % of all live children are born with a Congenital Heart Disease (CHD) due to genetic end environmental causes. Advanced treatment and care has enhanced survival substantially, and adults with CHD are a growing population requiring continuous monitoring and care. Presently 25% of young adults acquire complicating Cardio Vascular Diseases (CVD) in young adulthood amongst other co-morbidities.

It is known that adolescents with CHD are not as physical fit (PF) as their cardiac capability allows, most likely for reasons concerning safety, ability plus inactive everyday life. However, in 2006 The European Society of Cardiology states, that regular exercise at recommended levels can be performed and should be encouraged in all patients with CHD. Training programmes in hospitals have an effect on PF and Quality of Life (QoL) for the few, as most adolescents' find it impossible to fit into everyday life.

It is the investigators hypothesis that an eHealth intervention, to facilitate intensive exercise in the patients' neighbourhood environs, may improve physical fitness more efficiently than standard lifestyle education.

The purpose of the study is to create evidence to recommend an efficient, fun and safe cardiac rehabilitation programme to adolescents with CHD.

Primary outcome measure

Cardiopulmonary exercise capacity: Online V02 max bicycle test

Secondary outcome measure

Level of physical exercise: Actigraph and Questionnaire

Tertiary outcome measure

Quality of Life: PedsQl

Prevail is a national prospective, randomized clinical trial including 216 adolescents aged 13-16 years, who have had cardiac surgery in childhood owing to complex CHD. The patients included are all recommended to be as physical active as their healthy peers and pursue the principle guideline from The National Board of Health: "All children and young people must be physically active for at least 60 minutes a day, preferably longer". Patients with mental retardation and FEV1 at baseline \< 80% of predicted are excluded.

The risk of participating in the purposed trial is not regarded as higher than everyday daily living.

Results will be interpreted according to affiliation to health related fitness clusters.


Options:
A: Patient-reported health status (EuroQol-5D) (Baseline); Patient-reported psychosocial functioning (Hospital Anxiety and Depression Scale) (Baseline); Patient-reported behavioral outcomes (Health Behavior Scale - Congenital Heart Disease) (Baseline); Patient-reported quality of life (Linear Analog Scale Quality of Life;Satisfaction with Life Scale) (Baseline)
B: Maximal inspiratory pressure in kilopascal (12 weeks)
C: Cardiopulmonary exercise capacity (12 months)
D: Cardiac disease knowledge (12 months)

Answer: C