Please select the eligibility criteria that correspond to the clinical trial below.
Title: Early Prediction and Aspirin for Prevention of Preeclampsia
Brief Summary: This is a randomized controlled trial to estimate the efficacy of low dose aspirin for preventing preeclampsia in women identified as high risk. The investigators hypothesize that the risk of preeclampsia in women identified by a first trimester multiparameter predictive model to be at high risk will be significantly reduced by initiating low dose aspirin early in pregnancy.


Options:
A: Inclusion Criteria:

* Singleton pregnancy undergoing ultrasound examination at 9 0/7 - 14 6/7 weeks
* any one or more factors identified as high risk from the identified risk factors: Chronic hypertension, prepregnancy diabetes mellitus, previous preeclampsia, obesity (BMI \>30), bilateral uterine artery notches preeclampsia risk score greater than 6, low PAPP-A ( \< 0.52 MoM)

Exclusion Criteria:

* Multiple gestations,
* fetal aneuploidy
* major fetal structural anomaly
* bleeding disorder
* allergy to aspirin
* women already on aspirin or heparin.
B: Inclusion Criteria:

* Singleton pregnancy;
* Live fetus;

Exclusion Criteria:

* Multiple pregnancy;
* Major fetal defects identified at 11-13 weeks of assessment;
* Non-viable fetus (missed spontaneous abortion or stillbirth).
C: Inclusion Criteria:

* Singleton pregnancy with a pre-pregnancy diagnosis of type I or type II diabetes of at least 6 months' duration

Exclusion Criteria:

* • Aspirin hypersensitivity (prior bronchospasm/ urticarial/ angioedema with aspirin)

  * Peptic ulcer disease
  * Known bleeding diathesis
  * Multifetal gestation
  * Severe early-onset preeclampsia in a previous pregnancy
  * Patient already on aspirin
  * Established chronic renal disease/ macroalbuminuria
  * Chronic hypertension (antihypertensive therapy in first trimester)
  * Current selective serotonin reuptake inhibitor (SSRI) use (or SSRI use within 7 days)
  * Inability to speak or read English
  * Age less than 18 years
  * Use of any other investigational medicinal product within previous 30 days
  * Presence of any illness or condition that might interfere with the patient's ability to comply with the study procedures
D: Inclusion Criteria:

* Nulliparous women between 18 - 40 years of age. Minors who are ≥ 14 years of age may be enrolled if permitted by the country's ethical guidelines.
* No more than two previous first trimester pregnancy losses
* No medical contraindications to aspirin;
* Single live intrauterine pregnancy (IUP) between 6 0/7 and 13 6/7 weeks GA corroborated by an early dating ultrasound and with presence of a heartbeat.

Exclusion Criteria:

* Women prescribed daily aspirin for more than 7 days;
* Multiple gestations;
* Fetal anomaly by ultrasound (Note most fetal anomalies are not detectable by ultrasounds done at this early gestation. Subsequent discovery of a fetal anomaly is not viewed as an exclusion.);
* Hemoglobin \< 7.0 gm/dl at screening;
* Any other medical conditions that may be considered a contraindication per the judgment of the site investigator (e.g., Lupus, Type 1 Diabetes, or any other known significant disease)
* Blood pressure ≥ 140/90 (Systolic blood pressure ≥ 140 and diastolic ≥ 90 at screening)

Answer: A