Please select the eligibility criteria that correspond to the clinical trial below.
Title: The Diabetes Community Lifestyle Improvement Program (D-CLIP): A Translation Randomized Trial of a Culturally Specific Lifestyle Intervention for Diabetes Prevention in India
Brief Summary: People from the Indian subcontinent are more likely to get diabetes, even at younger ages. The Diabetes Community Lifestyle Improvement Program (D-CLIP) will test in a randomized trial if a culturally specific, community-based lifestyle and metformin (for individuals who do not respond to lifestyle change alone) intervention for men and women living in Chennai, India can effectively prevent type 2 diabetes in high-risk individuals. Lifestyle interventions are programs that seek to prevent disease by promoting changes in health behaviors, improved diet, increased physical activity, and weight loss. The results of this program will be used to make policy and public health recommendations, which will result in broader diabetes prevention efforts. The research team hypothesizes that this program will result in improvements in health (diabetes prevention, weight loss, and improvements in other markers of chronic disease) for intervention participants compared to participants in the control arm of the study.


Options:
A: Inclusion Criteria:

* Live in or near Chennai, India
* Aged 20-65 years
* A BMI \>22 kg/m2 and/or a waist circumference \>90 cm for men and \>80 cm for women
* No prior diabetes diagnosis, except for gestational diabetes
* At high risk of developing diabetes (pre-diabetes) as defined by a casual capillary glucose greater than or equal to 110 (measured during screening) AND Baseline fasting glucose of 100-125 mg/dL and/or 2-hour post-load glucose of 140-199 mg/dL
* Willingness to consent to randomization

Exclusion Criteria:

* Does not fulfill inclusion criteria
* Currently pregnant or breastfeeding
* History of or biomarkers indicating heart disease, serious illness, cancer diagnosis in the past 5 years, or other conditions that may impede or prohibit participation in an unsupervised diet change and physical activity program.
B: Inclusion Criteria:

* Adults age 20-55 inclusive
* BMI between 25 and 35 inclusive (overweight and Class 1 obese subjects)
* PC Computer with an available USB port, speakers and high-speed internet access in a secure setting (home or private office)
* Fluency in English (spoken and written)
* Have a Primary Care Physician
* Answer "No" to all 7 questions on PAR-Q OR have letter from PCP clearing them to take part in study

Exclusion Criteria:

* Disability, medical or surgical condition preventing or precluding moderate physical activity.
* Cognitive impairment.
C: Inclusion Criteria:

* high risk for gestational diabetes
* fasting glucose 4.8-5.5 mmol/l and 2-hour glucose of OGTT \<7.8 mmol/l

Exclusion Criteria:

* normal glucose tolerance at weeks 8-12
* gestational diabetes at weeks 8-12
D: Inclusion Criteria:

* Patients from one single health care centre with a diagnosis of:

  * Typ 2 diabetes,
  * Hypertension,
  * Obesity or
  * Dyslipidemia

Exclusion Criteria:

* Coronary heart
* Disease,
* Stroke,
* TIA,
* BP \>180/105,
* Dementia; or
* Severe psychiatric disease

Answer: A