Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in Bangladesh
Brief Summary: Oral polio and rotavirus vaccines are significantly less effective in children living in the developing world. Tropical enteropathy, which is associated with intestinal inflammation, decreased absorption and increased permeability, may contribute substantially to oral vaccine failure in developing country settings. Other possible causes of oral vaccine underperformance include malnutrition, interference with maternal or breastmilk antibodies, changes in gut microbiota, and genetic susceptibility.

Primary Objective: to determine whether tropical enteropathy impairs the efficacy of oral polio and rotavirus vaccines in children in Bangladesh.

Secondary Objectives: 1) to determine the impact of an IPV (inactivated polio vaccine) boost on the efficacy of OPV (oral polio vaccine) and 2) to determine the efficacy of Rotarix oral rotavirus vaccine to prevent rotavirus diarrhea

The polio and rotavirus randomized clinical trials are embedded as secondary objectives within the exploratory study of tropical enteropathy. The primary and secondary outcome measures are relevant to the randomized clinical trials.


Options:
A: Intervention Type: DRUG; Name: Zinc; Assigned to Arm(s): N/A
B: Arm Label: Rotarix + No IPV (inactivated polio vaccine); Type: EXPERIMENTAL; Interventions: Biological: Rotarix | Arm Label: Rotarix + IPV (inactivated polio vaccine); Type: EXPERIMENTAL; Interventions: Biological: IPV (inactivated polio vaccine), Biological: Rotarix | Arm Label: No Rotarix + No IPV (inactivated polio vaccine); Type: NO_INTERVENTION; Interventions: N/A | Arm Label: No Rotarix + IPV (inactivated polio vaccine); Type: EXPERIMENTAL; Interventions: Biological: IPV (inactivated polio vaccine) | Intervention Type: BIOLOGICAL; Name: IPV (inactivated polio vaccine); Assigned to Arm(s): No Rotarix + IPV (inactivated polio vaccine), Rotarix + IPV (inactivated polio vaccine) | Intervention Type: BIOLOGICAL; Name: Rotarix; Assigned to Arm(s): Rotarix + IPV (inactivated polio vaccine), Rotarix + No IPV (inactivated polio vaccine)
C: Arm Label: 1; Type: EXPERIMENTAL; Interventions: Drug: Zinc and vitamin A single dose at enrollment | Arm Label: 2; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo and vitamin A single dose at enrollment | Intervention Type: DRUG; Name: Zinc and vitamin A single dose at enrollment; Assigned to Arm(s): 1 | Intervention Type: DRUG; Name: Placebo and vitamin A single dose at enrollment; Assigned to Arm(s): 2
D: Arm Label: LNS-Zn5; Type: EXPERIMENTAL; Interventions: Dietary Supplement: LNS-Zn5 | Arm Label: LNS-Zn10; Type: EXPERIMENTAL; Interventions: Dietary Supplement: LNS-Zn10 | Arm Label: LNS-Zn0; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: LNS-Zn0 | Arm Label: Suppl-Zn5; Type: EXPERIMENTAL; Interventions: Dietary Supplement: Suppl-Zn5 | Arm Label: Delayed intervention group; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DIETARY_SUPPLEMENT; Name: LNS-Zn5; Assigned to Arm(s): LNS-Zn5 | Intervention Type: DIETARY_SUPPLEMENT; Name: LNS-Zn10; Assigned to Arm(s): LNS-Zn10 | Intervention Type: DIETARY_SUPPLEMENT; Name: LNS-Zn0; Assigned to Arm(s): LNS-Zn0 | Intervention Type: DIETARY_SUPPLEMENT; Name: Suppl-Zn5; Assigned to Arm(s): Suppl-Zn5

Answer: B