Please select the eligibility criteria that correspond to the clinical trial below.
Title: Immunological and Genomic Effects of an Online Mindfulness Program for Stress Management
Brief Summary: This is a prospective parallel non-blinded randomized study with two arms, an intervention group and an active control group.

Sixty healthy, but stressed nurses will be randomly assigned to either participate in a 6-week internet-based mindfulness meditation program produced by the Cleveland Clinic called Stress Free Now for Healers or to listen to relaxing music for at least 5 minutes a day for 6 weeks, and pre-post comparisons will be made for RNA expression profiles, plasma cytokine concentrations, telomerase activity, 6-point salivary cortisol and several self-reported assessments of physical and mental health.


Options:
A: Inclusion Criteria:

* Healthy male and female CCF nurses
* Abbreviated perceived stress scale (PSS-4) ≥ 7
* English speaking
* No history of major chronic medical conditions and/or diseases
* Able to provide informed consent and comply with study protocol

Exclusion Criteria:

* Significant chronic medical condition and/or disease
* Smoking
* Pregnancy
* Current use of antidepressants or any other psychiatric medication
* Current diagnosis of anxiety and/or depression
* History of any psychiatric diagnosis other than anxiety or depression
* Estrogen or hormone replacement therapy use
* Diagnosis of post-traumatic stress disorder
* Current use of any immunosuppressive medication
* No current or past meditation practice
B: Inclusion Criteria:

* Any consented medical intern from Emergency Medecine, Internal Medicine, Pediatrics, Family Practice, OBGYN and Surgery Depratments in-coming to University of California San Francisco in the study year.

Exclusion Criteria:

* Current personal mindfulness practice, once a week or more frequent;
* Use of medications with Central Nervous System effects;
* Lifetime history of an organic mental illness;
* Acute or chronic immune or inflammatory disorders;
* Pregnancy;
C: Inclusion criteria

* Nurses working in inpatient oncology-hematology, outpatient chemotherapy, or BMT unit Exclusion criteria
* Providing care for pediatric oncology patients
* Being a nurse manager
* Not providing direct patient care
D: Inclusion Criteria:

1. Adult ≥ 18 years old
2. Employed as a critical care nurse at Florida Hospital in an adult ICU, PICU, PCVICU, or Level 3 NICU at the Altamonte, Orlando, or Winter Park campus
3. Able to speak, read, and understand English fluently
4. Able to provide informed consent
5. Meet ≥ 2 stress experience level parameters on the Stress Mindset Measure - General (SMM-G)
6. Meet ≤ 4.3 on the Brief Resilience Scale (BRS)
7. Willing to attend a full-day training program at HPI on the designated training date
8. Willing and able to comply with all study procedures and requirements for the duration of the study.

Exclusion Criteria:

1. Meet \< 2 stress experience level parameters on the SMM-G
2. Meet \> 4.3 on the BRS
3. Receive a high score of ≥ 27 on the Emotional Exhaustion domain and/or a high score of ≥ 13 on the Depersonalization domain of the Maslach Burnout Inventory (MBI)

Answer: A