Please select the eligibility criteria that correspond to the clinical trial below.
Title: Multi-Port vs. Single-port Cholecystectomy
Brief Summary: The aim of this study is to compare results of the new surgical strategy to the traditional 4-ports technique for cholecystectomy in a randomized controlled trial (RCT). In particular we are going to investigate the procedures in terms of overall morbidity, while taking into considerations skin-incision's related morbidity, postoperative pain and cosmetic results which are the hypothetical benefits of the new approach. Other parameters are supposed to be unchanged, considering evidences from recent literature.

Surgical procedures:

4 ports cholecystectomy (4PC): a 12mmHg pneumoperitoeum is created either by a 10mm umbilical Hasson's port or by a Verress needle followed by a 10mm umbilical port insertion; further one 10mm and two 5mm ports are placed according to the preferred technique.

Single Port Access cholecystectomy (SPC): the single-port device is inserted through the umbilicus, by means of an adeguate incision, as the only access to the abdominal cavity. A trans-abdominal suture in right hypochondrium is placed through the gallbladder wall of the fundus to retract it.

Primary endpoint: overall morbidity rate (at 60 days from surgery)

Secondary endpoints:

1. skin-incision's related morbidity rate (at 60 days from surgery)
2. perioperative pain
3. cosmetic results
4. long-term morbidity (12 months)
5. intraoperative time
6. "conversion SPC to 4PC" rate
7. "conversion to laparotomy" rate
8. hospital stay


Options:
A: Inclusion Criteria:

* age: 18-75
* BMI: \<30
* ASA: I-III
* absence of non-correctable coagulopathy (international normalized ratio \>1,5, or platelet count \<90 × 109/l).
* diagnosis: cholelithiasis (gallstones \< 2 cm in diameter) gallbladder dyskinesia

Exclusion Criteria:

* cholecystitis
* suspected presence of common duct stones
* suspected presence of biliary cancer
* Previous abdominal surgery
* Previous umbilical surgery
B: Inclusion Criteria:

* age over 18 and under 65
* symptomatic cholelithiasis with an indication for performing laparoscopic surgery
* absence of any gynecological condition that could complicate the procedure (pelvic inflammatory disease or endometriosis)
* perforated hymen
* agreement on the patient's part not to use the vagina for two weeks after the surgery
* signed specific informed consent upon providing specific information about the new surgical approach.

Exclusion Criteria:

* age under 18 or over 65
* unperforated hymen
* presence of illness or condition with an increased risk of pelvic damage with transvaginal approach.
C: Inclusion Criteria:

* Pre-operative diagnosis of one of the following:

  * Pancreatic cholecystitis
  * Biliary cholic
  * Biliary dyskinesia
  * Choledocholithiasis status post endoscopic retrograde cholangiopancreatography/sphincterotomy
  * Gallbladder polyps
  * Other diagnosis at the discretion of the surgeon

Exclusion Criteria:

* Acute cholecystitis
* Gallstones \> 2.5cm in length on ultrasound
* Suspected presence of common duct stones
* History of jaundice
* History of gallstone pancreatic
D: Inclusion Criteria:

* age 18-75
* BMI \< 35
* no previous upper GI or right colonic surgery with severe adhesions gallstones with absence of clinical signs of acute cholecystitis, bile duct stones or pancreatitis.
* ASA I-III
* Nassar grade of difficulty in performing a laparoscopic cholecystectomy I-III
* diagnosis: cholelithiasis

Exclusion Criteria:

* cholecystitis
* existence of common duct stones
* presence of biliary cancer
* Previous abdominal surgery on organs of the supramesocolic space

Answer: A