TrialPanorama/Dataset huggingface dataset:
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Study of Perineal Protection Device
Brief Summary: Objective:

To investigate the protective effects of a newly invented device for reducing tears in the perineum during vaginal childbirth.

Design:

A multicenter randomized control trial performed at three hospitals in Sweden, in Helsingborg, Lund and Malmö. Participants recruited are women with vaginal delivery (N=1200), cephalic presentation. They will be randomized to an intervention group, with a perineal protection device, and a control group deliver as normal.

Main outcome measures:

The effect on the frequency and extension of perineal ruptures grade I, II and anal sphincter rupture are measured.


Options:
A: Arm Label: Anterior shoulder; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Primary delivery of anterior shoulder | Arm Label: Posterior shoulder; Type: EXPERIMENTAL; Interventions: Procedure: Primary delivery posterior shoulder | Intervention Type: PROCEDURE; Name: Primary delivery of anterior shoulder; Assigned to Arm(s): Anterior shoulder | Intervention Type: PROCEDURE; Name: Primary delivery posterior shoulder; Assigned to Arm(s): Posterior shoulder
B: Arm Label: I; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Ritgens maneuver | Arm Label: II; Type: OTHER; Interventions: Procedure: Standard care (Manual support of the perineum) | Intervention Type: PROCEDURE; Name: Ritgens maneuver; Assigned to Arm(s): I | Intervention Type: PROCEDURE; Name: Standard care (Manual support of the perineum); Assigned to Arm(s): II
C: Arm Label: Perineal device used; Type: OTHER; Interventions: Device: Perineal protection device | Arm Label: No intervention; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DEVICE; Name: Perineal protection device; Assigned to Arm(s): Perineal device used
D: Arm Label: Perineal Massage & Control; Type: EXPERIMENTAL; Interventions: Other: Perineal massage in childbirth | Intervention Type: OTHER; Name: Perineal massage in childbirth; Assigned to Arm(s): Perineal Massage & Control

Answer: C
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Study of Perineal Protection Device
Brief Summary: Objective:

To investigate the protective effects of a newly invented device for reducing tears in the perineum during vaginal childbirth.

Design:

A multicenter randomized control trial performed at three hospitals in Sweden, in Helsingborg, Lund and Malmö. Participants recruited are women with vaginal delivery (N=1200), cephalic presentation. They will be randomized to an intervention group, with a perineal protection device, and a control group deliver as normal.

Main outcome measures:

The effect on the frequency and extension of perineal ruptures grade I, II and anal sphincter rupture are measured.


Options:
A: Arm Label: I; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Ritgens maneuver | Arm Label: II; Type: OTHER; Interventions: Procedure: Standard care (Manual support of the perineum) | Intervention Type: PROCEDURE; Name: Ritgens maneuver; Assigned to Arm(s): I | Intervention Type: PROCEDURE; Name: Standard care (Manual support of the perineum); Assigned to Arm(s): II
B: Arm Label: CONTROL; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: VOCALIZATION; Type: EXPERIMENTAL; Interventions: Other: vocalization | Intervention Type: OTHER; Name: vocalization; Assigned to Arm(s): VOCALIZATION
C: Arm Label: hands on; Type: EXPERIMENTAL; Interventions: Procedure: hands on | Arm Label: hands off; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: PROCEDURE; Name: hands on; Assigned to Arm(s): hands on
D: Arm Label: Perineal device used; Type: OTHER; Interventions: Device: Perineal protection device | Arm Label: No intervention; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DEVICE; Name: Perineal protection device; Assigned to Arm(s): Perineal device used

Answer: D
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Community Based Management of Fast Breathing in Infants Aged < 60 Days: A Double-Blind, Randomized Placebo-Controlled Trial in Low-income Settlements of Karachi
Brief Summary: The aim of the study is to determine optimal management of isolated fast breathing in young infants in a trial design conducted in primary care settings.

The investigators hypothesized that proportion of infants who fail therapy will be 4% in each group. A 6% or less difference in failure rate will be considered equivalent.


Options:
A: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Dietary Supplement: Vitamin A | Arm Label: 2; Type: PLACEBO_COMPARATOR; Interventions: Dietary Supplement: Placebo | Intervention Type: DIETARY_SUPPLEMENT; Name: Vitamin A; Assigned to Arm(s): 1 | Intervention Type: DIETARY_SUPPLEMENT; Name: Placebo; Assigned to Arm(s): 2
B: Arm Label: Amoxicillin; Type: ACTIVE_COMPARATOR; Interventions: Drug: Amoxicillin | Arm Label: Sugar Syrup; Type: PLACEBO_COMPARATOR; Interventions: Drug: Sugar Syrup | Intervention Type: DRUG; Name: Amoxicillin; Assigned to Arm(s): Amoxicillin | Intervention Type: DRUG; Name: Sugar Syrup; Assigned to Arm(s): Sugar Syrup
C: Arm Label: ICCM delivered by VHT; Type: ACTIVE_COMPARATOR; Interventions: Other: ICCM delivered by VHT | Arm Label: ICCM delivered by VHT with cell phone; Type: ACTIVE_COMPARATOR; Interventions: Other: ICCM delivered by VHT, Other: ICCM delivered by VHT with Cell Phone | Arm Label: Health outcomes in communities with no ICCM; Type: ACTIVE_COMPARATOR; Interventions: Other: No intervention | Intervention Type: OTHER; Name: ICCM delivered by VHT; Assigned to Arm(s): ICCM delivered by VHT, ICCM delivered by VHT with cell phone | Intervention Type: OTHER; Name: ICCM delivered by VHT with Cell Phone; Assigned to Arm(s): ICCM delivered by VHT with cell phone | Intervention Type: OTHER; Name: No intervention; Assigned to Arm(s): Health outcomes in communities with no ICCM
D: Arm Label: nothing at home level; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Home management of malaria; Type: EXPERIMENTAL; Interventions: Other: home/community case management | Arm Label: Home management of malaria and pneumonia; Type: EXPERIMENTAL; Interventions: Other: home/community case management | Intervention Type: OTHER; Name: home/community case management; Assigned to Arm(s): Home management of malaria, Home management of malaria and pneumonia

Answer: B
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Acceptance & Commitment Therapy for Smoking Cessation (Aka PATH Study - Partnering to Achieve Tobacco-free Health)
Brief Summary: The overall aim of this 5-year project is to capitalize on the strong theoretical and promising empirical evidence for Acceptance \& Commitment Therapy (ACT) as an intervention for smoking cessation by comparing the effectiveness of ACT against standard cognitive behavioral therapy (CBT) counseling when both are offered with nicotine replacement therapy (NRT) and delivered within a real world healthcare setting.


Options:
A: Arm Label: Group psychotherapy group; Type: EXPERIMENTAL; Interventions: Behavioral: An online 5-week professional identity group psychotherapy | Arm Label: Controlled message push group; Type: OTHER; Interventions: Other: Message push | Intervention Type: BEHAVIORAL; Name: An online 5-week professional identity group psychotherapy; Assigned to Arm(s): Group psychotherapy group | Intervention Type: OTHER; Name: Message push; Assigned to Arm(s): Controlled message push group
B: Arm Label: Mindfulness-Based Treatment Group (MBAT); Type: EXPERIMENTAL; Interventions: Behavioral: MBAT Group Therapy, Drug: Nicotine | Arm Label: Standard Care Group; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine, Behavioral: Group Therapy | Arm Label: Usual Care Group; Type: ACTIVE_COMPARATOR; Interventions: Drug: Nicotine, Behavioral: Individual Therapy | Intervention Type: BEHAVIORAL; Name: MBAT Group Therapy; Assigned to Arm(s): Mindfulness-Based Treatment Group (MBAT) | Intervention Type: DRUG; Name: Nicotine; Assigned to Arm(s): Mindfulness-Based Treatment Group (MBAT), Standard Care Group, Usual Care Group | Intervention Type: BEHAVIORAL; Name: Group Therapy; Assigned to Arm(s): Standard Care Group | Intervention Type: BEHAVIORAL; Name: Individual Therapy; Assigned to Arm(s): Usual Care Group
C: Arm Label: ACT; Type: EXPERIMENTAL; Interventions: Other: Acceptance & Commitment Therapy (ACT) | Arm Label: CBT; Type: ACTIVE_COMPARATOR; Interventions: Other: Cognitive Behavioral Therapy (CBT) | Intervention Type: OTHER; Name: Acceptance & Commitment Therapy (ACT); Assigned to Arm(s): ACT | Intervention Type: OTHER; Name: Cognitive Behavioral Therapy (CBT); Assigned to Arm(s): CBT
D: Arm Label: Passive control group; Type: NO_INTERVENTION; Interventions: N/A | Arm Label: Planned intervention - mantra meditation; Type: EXPERIMENTAL; Interventions: Behavioral: Mantra Meditation | Intervention Type: BEHAVIORAL; Name: Mantra Meditation; Assigned to Arm(s): Planned intervention - mantra meditation

Answer: C
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Global SYMPLICITY Registry (GSR) Denervation Findings in Real World (DEFINE)
Brief Summary: This is a prospective, multi-center, single-arm, non-interventional and open-label registry. The purpose of the registry is to document the long-term safety and effectiveness of renal denervation in a real world patient population with hypertension GSR DEFINE is the continuation of the Global SYMPLICITY Registry and collectively will enroll approximately 5000 patients with hypertension who undergo the renal denervation procedure, from over 300 sites worldwide. Subjects included in GSR DEFINE will be followed for a minimum of 1 year and up to 5 years post-procedure. Patients with uncontrolled hypertension will be enrolled in accordance with the inclusion criteria specified in the protocol.


Options:
A: Arm Label: Renal Denervation Treatment; Type: N/A; Interventions: Device: Medtronic Renal Denervation System | Intervention Type: DEVICE; Name: Medtronic Renal Denervation System; Assigned to Arm(s): Renal Denervation Treatment
B: Arm Label: Renal Denervation; Type: EXPERIMENTAL; Interventions: Device: Renal Denervation (Symplicity® Renal Denervation System) | Arm Label: Control; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DEVICE; Name: Renal Denervation (Symplicity® Renal Denervation System); Assigned to Arm(s): Renal Denervation
C: Arm Label: Renal Denervation; Type: EXPERIMENTAL; Interventions: Device: Symplicity Spyral™ multi-electrode renal denervation system | Arm Label: Sham Procedure; Type: SHAM_COMPARATOR; Interventions: Procedure: Sham Procedure | Intervention Type: DEVICE; Name: Symplicity Spyral™ multi-electrode renal denervation system; Assigned to Arm(s): Renal Denervation | Intervention Type: PROCEDURE; Name: Sham Procedure; Assigned to Arm(s): Sham Procedure
D: Arm Label: Circumferential PVI; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Circumferential PV isolation | Arm Label: Circumferential PVI+renal denervation; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Circumferential PVI+renal denervation | Intervention Type: PROCEDURE; Name: Circumferential PV isolation; Assigned to Arm(s): Circumferential PVI | Intervention Type: PROCEDURE; Name: Circumferential PVI+renal denervation; Assigned to Arm(s): Circumferential PVI+renal denervation

Answer: A
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Self-administered Intravaginal 2% Lidocaine Gel Prior to Intrauterine Device Insertion in Nulliparous Women: a Randomized Controlled Trial
Brief Summary: This study is designed to evaluate if self-inserted intravaginal 2% lidocaine gel is effective at decreasing pain during intrauterine device insertion in nulliparous women.


Options:
A: Arm Label: LNG-IUS; Type: N/A; Interventions: Other: Evaluation of uterine size and posture with ultrasound, IUD insertion, one year follow-up. | Arm Label: Cu-IUD; Type: N/A; Interventions: Other: Evaluation of uterine size and posture with ultrasound, IUD insertion, one year follow-up. | Intervention Type: OTHER; Name: Evaluation of uterine size and posture with ultrasound, IUD insertion, one year follow-up.; Assigned to Arm(s): Cu-IUD, LNG-IUS
B: Arm Label: intracervical anesthesia; Type: ACTIVE_COMPARATOR; Interventions: Drug: Intracervical anesthesia with lidocaine 2% | Arm Label: ibuprofen; Type: ACTIVE_COMPARATOR; Interventions: Drug: ibuprofen 400 mg | Intervention Type: DRUG; Name: Intracervical anesthesia with lidocaine 2%; Assigned to Arm(s): intracervical anesthesia | Intervention Type: DRUG; Name: ibuprofen 400 mg; Assigned to Arm(s): ibuprofen
C: Arm Label: Group 1: Intravaginal 2% lidocaine gel; Type: EXPERIMENTAL; Interventions: Drug: Lidocaine | Arm Label: Group 2: Intravaginal placebo gel; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Lidocaine; Assigned to Arm(s): Group 1: Intravaginal 2% lidocaine gel | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Group 2: Intravaginal placebo gel
D: Arm Label: Control Group; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo gel | Arm Label: Study Group; Type: EXPERIMENTAL; Interventions: Drug: 2% lidocaine gel | Intervention Type: DRUG; Name: 2% lidocaine gel; Assigned to Arm(s): Study Group | Intervention Type: DRUG; Name: Placebo gel; Assigned to Arm(s): Control Group

Answer: C
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Controlled Randomized Study of Protack, Securestrap and Glubran Glue as Fixation Devices in Laparoscopic Ventral Herniotomy
Brief Summary: Clinical, controlled, randomized, prospective study. Ventral hernias between 2(1.5)cm and 7 cm, laparoscopic surgery with intraperitoneal onlay mesh.

Three randomization groups of 25 patients giving a total of 75 patients. Mesh is fixated with either Protack, Securestrap or Glubran II. Primary outcome: postoperative pain on the 2nd postoperative day. Secondary outcomes: pain, quality of life, recurrence and adhesions at 1, 6, 12, 24, 36, 48 and 60 months postoperative.


Options:
A: Arm Label: 1; Type: OTHER; Interventions: Procedure: Open mesh repair of ventral incisional hernia, Procedure: Laparoscopic mesh repair of ventral incisional hernia | Intervention Type: PROCEDURE; Name: Open mesh repair of ventral incisional hernia; Assigned to Arm(s): 1 | Intervention Type: PROCEDURE; Name: Laparoscopic mesh repair of ventral incisional hernia; Assigned to Arm(s): 1
B: Arm Label: fixation with Protack; Type: EXPERIMENTAL; Interventions: Procedure: laparoscopic ventral herniotomy, Device: Protack | Arm Label: fixation with Securestrap; Type: EXPERIMENTAL; Interventions: Procedure: laparoscopic ventral herniotomy, Device: Securestrap | Arm Label: fixation with Glubran; Type: EXPERIMENTAL; Interventions: Procedure: laparoscopic ventral herniotomy, Device: Glubran | Intervention Type: PROCEDURE; Name: laparoscopic ventral herniotomy; Assigned to Arm(s): fixation with Glubran, fixation with Protack, fixation with Securestrap | Intervention Type: DEVICE; Name: Protack; Assigned to Arm(s): fixation with Protack | Intervention Type: DEVICE; Name: Securestrap; Assigned to Arm(s): fixation with Securestrap | Intervention Type: DEVICE; Name: Glubran; Assigned to Arm(s): fixation with Glubran
C: Arm Label: Group A; Type: OTHER; Interventions: Procedure: Laparoscopic incisional or ventral hernia repair | Arm Label: Group B; Type: OTHER; Interventions: Procedure: Laparoscopic incisional or ventral hernia repair | Intervention Type: PROCEDURE; Name: Laparoscopic incisional or ventral hernia repair; Assigned to Arm(s): Group A, Group B
D: Arm Label: 0; Type: ACTIVE_COMPARATOR; Interventions: Procedure: laparoscopic correction of hernia with mesh | Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Procedure: laparoscopic correction of hernia with mesh | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Procedure: laparoscopic correction of hernia with mesh | Intervention Type: PROCEDURE; Name: laparoscopic correction of hernia with mesh; Assigned to Arm(s): 0, 1, 2

Answer: B
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Pain Relief Trial Utilizing the Infiltration of a Multivesicular Liposome Formulation of Bupivacaine, EXPAREL(R): A Phase 4 Health Economic Trial in Adult Patients Undergoing Laparoscopic Colectomy (IMPROVE-Lap Colectomy)
Brief Summary: This study is designed to compare the standard of care against EXPAREL (bupivacaine liposome injectable suspension) to determine if total opioid consumption is reduced when using EXPAREL, therefore possibly reducing total hospital costs.


Options:
A: Arm Label: Bupivacaine HCl; Type: ACTIVE_COMPARATOR; Interventions: Drug: Bupivacaine HCl | Arm Label: SKY0402; Type: OTHER; Interventions: Drug: SKY0402 | Intervention Type: DRUG; Name: Bupivacaine HCl; Assigned to Arm(s): Bupivacaine HCl | Intervention Type: DRUG; Name: SKY0402; Assigned to Arm(s): SKY0402
B: Arm Label: IV morphine sulfate; Type: ACTIVE_COMPARATOR; Interventions: Drug: IV morphine sulfate | Arm Label: EXPAREL; Type: EXPERIMENTAL; Interventions: Drug: EXPAREL (bupivacaine liposome injectable suspension) | Intervention Type: DRUG; Name: IV morphine sulfate; Assigned to Arm(s): IV morphine sulfate | Intervention Type: DRUG; Name: EXPAREL (bupivacaine liposome injectable suspension); Assigned to Arm(s): EXPAREL
C: Arm Label: Bupivacaine HCl 105mg; Type: ACTIVE_COMPARATOR; Interventions: Drug: Bupivacaine HCl | Arm Label: SKY0402 low dose; Type: EXPERIMENTAL; Interventions: Drug: SKY0402 | Arm Label: SKY0402 Middle dose; Type: EXPERIMENTAL; Interventions: Drug: SKY0402 | Arm Label: SKY0402 High dose; Type: EXPERIMENTAL; Interventions: Drug: SKY0402 | Intervention Type: DRUG; Name: Bupivacaine HCl; Assigned to Arm(s): Bupivacaine HCl 105mg | Intervention Type: DRUG; Name: SKY0402; Assigned to Arm(s): SKY0402 High dose, SKY0402 Middle dose, SKY0402 low dose
D: Arm Label: IV Morphine Sulfate or Sponsor-approved Equivalent; Type: ACTIVE_COMPARATOR; Interventions: Drug: IV morphine sulfate or Sponsor-approved equivalent | Arm Label: EXPAREL; Type: EXPERIMENTAL; Interventions: Drug: EXPAREL | Intervention Type: DRUG; Name: IV morphine sulfate or Sponsor-approved equivalent; Assigned to Arm(s): IV Morphine Sulfate or Sponsor-approved Equivalent | Intervention Type: DRUG; Name: EXPAREL; Assigned to Arm(s): EXPAREL

Answer: D
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Structured Non-operative Treatment of Knee Osteoarthritis - a Randomized Controlled Trial of Pain, Physical Function and Quality of Life With 12months Follow-up
Brief Summary: The purpose of this study is to test whether an algorithm for systematic non-surgical treatment consisting of corrective insoles, neuromuscular training, weight loss, patient education and pharmacological treatment with paracetamol, non steroidal anti inflammatory drugs (NSAIDs) and Pantoprazole provides further improvement in pain, function and quality of life than standard non-surgical treatment (information on the disease and how to treat it) in patients with knee osteoarthritis.

The H1-hypothesis is that the treatment algorithm results in a greater increase in quality of life and functional capacity and greater reduction in pain than standard treatment at the primary endpoint, which is follow-up 12months after the start of the treatment.

See statistical analysis plan available under "Links" for further description of the study.


Options:
A: Intervention Type: DRUG; Name: Diclofenac sodium gel 1%; Assigned to Arm(s): N/A
B: Arm Label: MEDIC; Type: ACTIVE_COMPARATOR; Interventions: Other: Neuromuscular training (NEMEX-TJR), Drug: Paracetamol, Drug: Burana, Drug: Pantoprazole, Behavioral: Dietary counseling, Behavioral: Patient education, Other: Insoles | Arm Label: Standard treatment; Type: ACTIVE_COMPARATOR; Interventions: Behavioral: Information | Intervention Type: OTHER; Name: Neuromuscular training (NEMEX-TJR); Assigned to Arm(s): MEDIC | Intervention Type: BEHAVIORAL; Name: Information; Assigned to Arm(s): Standard treatment | Intervention Type: DRUG; Name: Paracetamol; Assigned to Arm(s): MEDIC | Intervention Type: DRUG; Name: Burana; Assigned to Arm(s): MEDIC | Intervention Type: DRUG; Name: Pantoprazole; Assigned to Arm(s): MEDIC | Intervention Type: BEHAVIORAL; Name: Dietary counseling; Assigned to Arm(s): MEDIC | Intervention Type: BEHAVIORAL; Name: Patient education; Assigned to Arm(s): MEDIC | Intervention Type: OTHER; Name: Insoles; Assigned to Arm(s): MEDIC
C: Arm Label: Huo-Luo-Xiao-Ling; Type: ACTIVE_COMPARATOR; Interventions: Drug: HLXL | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: HLXL | Intervention Type: DRUG; Name: HLXL; Assigned to Arm(s): Huo-Luo-Xiao-Ling, Placebo
D: Intervention Type: DRUG; Name: Glucosamine sulfate; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: Acetaminophen; Assigned to Arm(s): N/A

Answer: B