Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Supplemental Parenteral Nutrition in Critically Ill Adults: A Pilot Randomised Controlled Trial
Brief Summary: One of the essential treatments for assisting patients in their recovery from illness is the provision of nutrition in a liquid form which is delivered into the stomach or as a fluid into the vein. Until recently the benefits of nutrition were undervalued in the critically ill, however, it has now become clear that targeted nutrition can positively affect a person's outcome. This is particularly important for patients who are significantly unwell and require increased amounts of nutrition to support recovery. Inadequate nutrition therapy leads them to rapidly lose weight, predominantly in the form of muscle loss which greatly contributes to their poor recovery.

Whilst nutrition is essential for recovery, there are several issues with the delivery of nutrition via the stomach (the most commonly used method of delivering nutrition in the critically ill). For many reasons, patients are unable to tolerate large quantities of nutrition via the stomach and in addition to this there are hospital or procedural reasons for nutrition being turned off for lengthy periods of time. As such, this results in patients being delivered only about half of the nutrition that is planned. One potential way to overcome this is to deliver nutrition via the vein, whilst nutrition into the stomach continues, with the aim to meet the energy gap that is lost by inadequate nutrition via the stomach.

In this study of 100 patients, we will deliver combined nutrition via the vein and stomach in 50 patients and the other 50 patients will receive nutrition as per normal practice. We will measure important outcomes for these patients to determine if this allows us to meet significantly more of their nutrition needs. This study will also help us determine how best to design a larger study of this strategy.


Options:
A: Arm Label: Standard Care; Type: OTHER; Interventions: Other: Standard Care | Arm Label: Supplemental PN; Type: EXPERIMENTAL; Interventions: Other: Supplemental PN | Intervention Type: OTHER; Name: Supplemental PN; Assigned to Arm(s): Supplemental PN | Intervention Type: OTHER; Name: Standard Care; Assigned to Arm(s): Standard Care
B: Arm Label: EN only; Type: EXPERIMENTAL; Interventions: Other: Withholding PN during the first week of ICU stay | Arm Label: EN plus early PN; Type: ACTIVE_COMPARATOR; Interventions: Drug: Oliclinomel N71000 OR N71000E // Clinimix N17G35 OR N17G35E | Intervention Type: OTHER; Name: Withholding PN during the first week of ICU stay; Assigned to Arm(s): EN only | Intervention Type: DRUG; Name: Oliclinomel N71000 OR N71000E // Clinimix N17G35 OR N17G35E; Assigned to Arm(s): EN plus early PN
C: Arm Label: Enteral Nutrition + Parenteral Nutrition; Type: EXPERIMENTAL; Interventions: Drug: Olimel (5.7%E / N9E) | Arm Label: Enteral Nutrition Only; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: DRUG; Name: Olimel (5.7%E / N9E); Assigned to Arm(s): Enteral Nutrition + Parenteral Nutrition
D: Arm Label: Early Goal-Directed Nutrition; Type: EXPERIMENTAL; Interventions: Other: Early Goal-Directed Nutrition | Arm Label: ASPEN-guidelines; Type: ACTIVE_COMPARATOR; Interventions: Other: ASPEN-guidelines | Intervention Type: OTHER; Name: Early Goal-Directed Nutrition; Assigned to Arm(s): Early Goal-Directed Nutrition | Intervention Type: OTHER; Name: ASPEN-guidelines; Assigned to Arm(s): ASPEN-guidelines

Answer: A