Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Randomised, Double-blind, 5 Treatment Arms, 4-period, Incomplete Cross-over Study to Determine the Effect of 6 Weeks Treatment of Orally Inhaled Tiotropium + Olodaterol Fixed Dose Combination (FDC) (2.5 / 5 µg; and 5 / 5 µg) (Delivered by the Respimat® Inhaler) Compared With Tiotropium (5 µg), Olodaterol (5 µg ) and Placebo (Delivered by the Respimat® Inhaler) on Lung Hyperinflation and Exercise Endurance Time During Constant Work Rate Cycle Ergometry in Patients With Chronic Obstructive Pulmonary Disease (COPD) [MORACTO TM 1]
Brief Summary: The primary objective of this trial is to investigate the effect of 6 weeks treatment with tiotropium + olodaterol fixed dose combination inhalation solution on lung hyperinflation and exercise tolerance in patients with COPD


Options:
A: Arm Label: NVA237 + indacaterol; Type: ACTIVE_COMPARATOR; Interventions: Drug: NVA237 50 µg and indacaterol 150 µg | Arm Label: Placebo to NVA237 + indacaterol; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo to NVA237 and indacaterol 150 µg | Intervention Type: DRUG; Name: NVA237 50 µg and indacaterol 150 µg; Assigned to Arm(s): NVA237 + indacaterol | Intervention Type: DRUG; Name: Placebo to NVA237 and indacaterol 150 µg; Assigned to Arm(s): Placebo to NVA237 + indacaterol
B: Arm Label: Tiotropium + olodaterol High dose QD; Type: EXPERIMENTAL; Interventions: Drug: tiotropium + olodaterol, Device: Respimat | Arm Label: Tiotropium + olodaterol Low dose QD; Type: EXPERIMENTAL; Interventions: Drug: Tiotropium + Olodaterol, Device: Respimat | Arm Label: Tiotropium 5 mcg QD; Type: ACTIVE_COMPARATOR; Interventions: Drug: Tiotropium, Device: Respimat | Arm Label: Olodaterol 5 mcg QD; Type: ACTIVE_COMPARATOR; Interventions: Drug: Olodaterol, Device: Respimat | Arm Label: Placebo QD; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo, Device: Respimat | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo QD | Intervention Type: DRUG; Name: Tiotropium; Assigned to Arm(s): Tiotropium 5 mcg QD | Intervention Type: DRUG; Name: Olodaterol; Assigned to Arm(s): Olodaterol 5 mcg QD | Intervention Type: DRUG; Name: tiotropium + olodaterol; Assigned to Arm(s): Tiotropium + olodaterol High dose QD | Intervention Type: DRUG; Name: Tiotropium + Olodaterol; Assigned to Arm(s): Tiotropium + olodaterol Low dose QD | Intervention Type: DEVICE; Name: Respimat; Assigned to Arm(s): Olodaterol 5 mcg QD, Placebo QD, Tiotropium + olodaterol High dose QD, Tiotropium + olodaterol Low dose QD, Tiotropium 5 mcg QD
C: Arm Label: indacaterol and glycopyrronium bromide (QVA149); Type: EXPERIMENTAL; Interventions: Drug: indacaterol and glycopyrronium bromide (QVA149) | Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo | Arm Label: tiotropium; Type: ACTIVE_COMPARATOR; Interventions: Drug: tiotropium | Intervention Type: DRUG; Name: indacaterol and glycopyrronium bromide (QVA149); Assigned to Arm(s): indacaterol and glycopyrronium bromide (QVA149) | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): placebo | Intervention Type: DRUG; Name: tiotropium; Assigned to Arm(s): tiotropium
D: Arm Label: tiotropium + olodaterol low dose; Type: EXPERIMENTAL; Interventions: Drug: olodaterol, Drug: tiotropium | Arm Label: tiotropium + olodaterol high dose; Type: EXPERIMENTAL; Interventions: Drug: olodaterol, Drug: tiotropium | Arm Label: tiotropium; Type: ACTIVE_COMPARATOR; Interventions: Drug: tiotropium | Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo | Intervention Type: DRUG; Name: olodaterol; Assigned to Arm(s): tiotropium + olodaterol high dose, tiotropium + olodaterol low dose | Intervention Type: DRUG; Name: tiotropium; Assigned to Arm(s): tiotropium, tiotropium + olodaterol high dose, tiotropium + olodaterol low dose | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): placebo

Answer: B