TrialPanorama/Dataset huggingface dataset:
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Remote Ischemic Postconditioning During Percutaneous Coronary Interventions.
Brief Summary: Angioplasty is a commonly performed procedure for treating blockage of the blood vessels in the heart. Although this procedure is usually successful, it is often accompanied by a small degree of damage to the heart (i.e., small heart attack).

The purpose of this study is to find out if inflating a blood pressure cuff on the arm or the leg at the time of angioplasty for several minutes has a beneficial effect.

Patients will be assigned to one of three treatment groups: inflating blood pressure cuff on the arm, inflating blood pressure cuff on the leg and a control group.


Options:
A: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Procedure: remote ischemic postconditioning | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Procedure: remote ischemic postconditioning | Arm Label: 3; Type: PLACEBO_COMPARATOR; Interventions: Procedure: remote ischemic postconditioning | Intervention Type: PROCEDURE; Name: remote ischemic postconditioning; Assigned to Arm(s): 1, 2, 3
B: Arm Label: Thrombolysis + Remote perconditioning; Type: EXPERIMENTAL; Interventions: Procedure: Thrombolysis + remote perconditioning | Arm Label: Thrombolysis; Type: ACTIVE_COMPARATOR; Interventions: Drug: Actilyse | Intervention Type: DRUG; Name: Actilyse; Assigned to Arm(s): Thrombolysis | Intervention Type: PROCEDURE; Name: Thrombolysis + remote perconditioning; Assigned to Arm(s): Thrombolysis + Remote perconditioning
C: Arm Label: Remote preconditioning; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Remote ischemic preconditioning | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Procedure: Placebo | Intervention Type: PROCEDURE; Name: Remote ischemic preconditioning; Assigned to Arm(s): Remote preconditioning | Intervention Type: PROCEDURE; Name: Placebo; Assigned to Arm(s): Placebo
D: Intervention Type: PROCEDURE; Name: remote ischemic preconditioning; Assigned to Arm(s): N/A

Answer: A
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Prevention of Hypertension in Patients With Pre-hypertension: PREVER-prevention Study
Brief Summary: The incidence of hypertension in individuals with pre-hypertension was 80% in ten years in a study conducted in Southern Brazil. The effectiveness of non-drug interventions to prevent hypertension is low in the long term. It may be hypothesized that a population-based drug intervention could reduce relevantly the burden of hypertension and cardiovascular disease.

Diuretics are at least as efficacious as other blood pressure-lowering drugs, are well tolerated, have longer duration of action and the advantage of very low cost to be used in a population intervention. Chlorthalidone is the more efficacious agent. Its main limitation is to induce hypokalemia in a proportion of patients, an adverse effect that can be antagonized by a potassium-sparing diuretic, as amiloride.

A study with this objective is therefore recommendable in Brazil, in order to support a plan of precocious intervention in individuals with pre-hypertension. Such a study was demanded and funded by the Health and Technology Ministries in Brazil.


Options:
A: Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo | Arm Label: chlortalidone-amiloride; Type: EXPERIMENTAL; Interventions: Drug: Chlorthalidone plus amiloride | Intervention Type: DRUG; Name: Chlorthalidone plus amiloride; Assigned to Arm(s): chlortalidone-amiloride | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): placebo
B: Intervention Type: DRUG; Name: Telmisartan; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: Combination of Telmisartan and Ramipril; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: Ramipril; Assigned to Arm(s): N/A
C: Intervention Type: DRUG; Name: Inhibitors, ACE; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: amlodipine; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: lisinopril; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: doxazosin; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: chlorthalidone; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: pravastatin; Assigned to Arm(s): N/A | Intervention Type: BEHAVIORAL; Name: diet, fat-restricted; Assigned to Arm(s): N/A
D: Intervention Type: DRUG; Name: Ramipril; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: Rosiglitazone; Assigned to Arm(s): N/A

Answer: A
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Prevention of Hypertension in Patients With Pre-hypertension: PREVER-prevention Study
Brief Summary: The incidence of hypertension in individuals with pre-hypertension was 80% in ten years in a study conducted in Southern Brazil. The effectiveness of non-drug interventions to prevent hypertension is low in the long term. It may be hypothesized that a population-based drug intervention could reduce relevantly the burden of hypertension and cardiovascular disease.

Diuretics are at least as efficacious as other blood pressure-lowering drugs, are well tolerated, have longer duration of action and the advantage of very low cost to be used in a population intervention. Chlorthalidone is the more efficacious agent. Its main limitation is to induce hypokalemia in a proportion of patients, an adverse effect that can be antagonized by a potassium-sparing diuretic, as amiloride.

A study with this objective is therefore recommendable in Brazil, in order to support a plan of precocious intervention in individuals with pre-hypertension. Such a study was demanded and funded by the Health and Technology Ministries in Brazil.


Options:
A: Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo | Arm Label: chlortalidone-amiloride; Type: EXPERIMENTAL; Interventions: Drug: Chlorthalidone plus amiloride | Intervention Type: DRUG; Name: Chlorthalidone plus amiloride; Assigned to Arm(s): chlortalidone-amiloride | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): placebo
B: Intervention Type: DRUG; Name: Indapamide SR 1.5mg; Perindopril 2-4mg; Assigned to Arm(s): N/A
C: Intervention Type: DRUG; Name: valsartan; Assigned to Arm(s): N/A
D: Intervention Type: DRUG; Name: Aliskiren; Assigned to Arm(s): N/A

Answer: A
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Prevention of Hypertension in Patients With Pre-hypertension: PREVER-prevention Study
Brief Summary: The incidence of hypertension in individuals with pre-hypertension was 80% in ten years in a study conducted in Southern Brazil. The effectiveness of non-drug interventions to prevent hypertension is low in the long term. It may be hypothesized that a population-based drug intervention could reduce relevantly the burden of hypertension and cardiovascular disease.

Diuretics are at least as efficacious as other blood pressure-lowering drugs, are well tolerated, have longer duration of action and the advantage of very low cost to be used in a population intervention. Chlorthalidone is the more efficacious agent. Its main limitation is to induce hypokalemia in a proportion of patients, an adverse effect that can be antagonized by a potassium-sparing diuretic, as amiloride.

A study with this objective is therefore recommendable in Brazil, in order to support a plan of precocious intervention in individuals with pre-hypertension. Such a study was demanded and funded by the Health and Technology Ministries in Brazil.


Options:
A: Arm Label: placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: placebo | Arm Label: chlortalidone-amiloride; Type: EXPERIMENTAL; Interventions: Drug: Chlorthalidone plus amiloride | Intervention Type: DRUG; Name: Chlorthalidone plus amiloride; Assigned to Arm(s): chlortalidone-amiloride | Intervention Type: DRUG; Name: placebo; Assigned to Arm(s): placebo
B: Intervention Type: DRUG; Name: Ramipril; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: Rosiglitazone; Assigned to Arm(s): N/A
C: Arm Label: Blood pressure; Type: PLACEBO_COMPARATOR; Interventions: Drug: Perindopril-indapamide | Arm Label: Glucose control; Type: OTHER; Interventions: Drug: Gliclazide MR-based glucose lowering | Intervention Type: DRUG; Name: Perindopril-indapamide; Assigned to Arm(s): Blood pressure | Intervention Type: DRUG; Name: Gliclazide MR-based glucose lowering; Assigned to Arm(s): Glucose control
D: Arm Label: felodipine group, active, pill; Type: ACTIVE_COMPARATOR; Interventions: Drug: Felodipine | Arm Label: placebo, no treatment, pill; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Felodipine; Assigned to Arm(s): felodipine group, active, pill | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): placebo, no treatment, pill

Answer: A
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Randomized Clinical Trial Comparing Axillary Dissection "by Principle" and Axillary Dissection Based on the Histological Result of the Sentinel Node, in Patients With Breast Carcinoma of Small Size
Brief Summary: The purpose of this study is to evaluate the disease free and overall survival of patients with breast carcinomas of small size, i.e., not greater than 2.0 cm and with clinically non palpable axillary lymph nodes, undergoing either conservative surgery and axillary dissection, or a similar treatment for the primary tumor and rapid analysis of the sentinel lymph node, the result of which determines axillary node dissection or its avoidance is based.


Options:
A: Arm Label: QUART; Type: ACTIVE_COMPARATOR; Interventions: Procedure: quadrantectomy and axillary dissection | Arm Label: QURT (SN-); Type: EXPERIMENTAL; Interventions: Procedure: quadrantectomy + sentinel node biopsy | Intervention Type: PROCEDURE; Name: quadrantectomy and axillary dissection; Assigned to Arm(s): QUART | Intervention Type: PROCEDURE; Name: quadrantectomy + sentinel node biopsy; Assigned to Arm(s): QURT (SN-)
B: Intervention Type: PROCEDURE; Name: Conventional surgery; Assigned to Arm(s): N/A
C: Intervention Type: DRUG; Name: tamoxifen citrate; Assigned to Arm(s): N/A | Intervention Type: PROCEDURE; Name: conventional surgery; Assigned to Arm(s): N/A
D: Arm Label: axillary lymph node dissection; Type: ACTIVE_COMPARATOR; Interventions: Procedure: axillary lymph node dissection, Procedure: lymphoscintigraphy, Procedure: therapeutic conventional surgery | Arm Label: axillary radiotherapy; Type: EXPERIMENTAL; Interventions: Procedure: lymphoscintigraphy, Procedure: therapeutic conventional surgery, Radiation: radiation therapy | Intervention Type: PROCEDURE; Name: axillary lymph node dissection; Assigned to Arm(s): axillary lymph node dissection | Intervention Type: PROCEDURE; Name: lymphoscintigraphy; Assigned to Arm(s): axillary lymph node dissection, axillary radiotherapy | Intervention Type: PROCEDURE; Name: therapeutic conventional surgery; Assigned to Arm(s): axillary lymph node dissection, axillary radiotherapy | Intervention Type: RADIATION; Name: radiation therapy; Assigned to Arm(s): axillary radiotherapy

Answer: A
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Effect of a Higher Than Maximum 450IU Gonadotropin Dose on Patient Outcomes in an In-Vitro Fertilization Setting: a Randomized Controlled Non-infertility Trial
Brief Summary: This goal of this study is to evaluate the outcomes from in vitro fertilization cycles where a 450 IU daily dose of gonadotropins is administered compared to those where a 600 IU daily dose is administered for women who are at risk of a poor ovarian response in order to determine if one dose or the other results in improved cycle outcomes.


Options:
A: Arm Label: 450 IU daily dose of gonadotrophin; Type: ACTIVE_COMPARATOR; Interventions: Drug: menotropins for injection, Drug: urofollitropin for injection | Arm Label: 600 IU daily dose of gonadotrophin; Type: EXPERIMENTAL; Interventions: Drug: menotropins for injection, Drug: urofollitropin for injection | Intervention Type: DRUG; Name: menotropins for injection; Assigned to Arm(s): 450 IU daily dose of gonadotrophin, 600 IU daily dose of gonadotrophin | Intervention Type: DRUG; Name: urofollitropin for injection; Assigned to Arm(s): 450 IU daily dose of gonadotrophin, 600 IU daily dose of gonadotrophin
B: Arm Label: Highly Purified Menotrophin; Type: EXPERIMENTAL; Interventions: Drug: Highly purified menotrophin | Arm Label: Recombinant FSH; Type: ACTIVE_COMPARATOR; Interventions: Drug: Recombinant FSH | Intervention Type: DRUG; Name: Highly purified menotrophin; Assigned to Arm(s): Highly Purified Menotrophin | Intervention Type: DRUG; Name: Recombinant FSH; Assigned to Arm(s): Recombinant FSH
C: Arm Label: A; Type: EXPERIMENTAL; Interventions: Drug: Follitropin Delta (FE 999049) | Arm Label: B; Type: ACTIVE_COMPARATOR; Interventions: Drug: Follitropin Alfa (GONAL-F) | Intervention Type: DRUG; Name: Follitropin Delta (FE 999049); Assigned to Arm(s): A | Intervention Type: DRUG; Name: Follitropin Alfa (GONAL-F); Assigned to Arm(s): B
D: Arm Label: AMH-group; Type: EXPERIMENTAL; Interventions: Other: AMH-analysis | Arm Label: Non-AMH-group; Type: NO_INTERVENTION; Interventions: N/A | Intervention Type: OTHER; Name: AMH-analysis; Assigned to Arm(s): AMH-group

Answer: A
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Comparison Between Diuretics and Angiotensin-receptor Blocker Agents in Patients With Stage I Hypertension: PREVER-treatment Study
Brief Summary: High blood pressure is the major risk factor for Cardiovascular disease (CVD). The prevalence of hypertension in Brazil was established in population-based studies conducted in different cities and States, varying from 22.3 to 44% of adults.

The benefit of drug treatment of hypertension to prevent major cardiovascular events was consistently demonstrated in a large series of clinical trials controlled by placebo.

Diuretics are at least as efficacious as other blood pressure-lowering drugs, are well tolerated, have longer duration of action and the advantage of very low cost to be used in a population intervention. Chlorthalidone is the more efficacious agent. Its main limitation is to induce hypokalemia in a proportion of patients, an adverse effect that can be antagonized by a potassium-sparing diuretic, as amiloride.

A study comparing diuretic with an ARB agent is therefore recommendable in Brazil, in order to support the decisions of the Health Secretary in regard to blood pressure agents supply for the Brazilian population. Such a study was demanded and funded by the Health and Technology Ministries in Brazil.


Options:
A: Arm Label: Aliskiren; Type: EXPERIMENTAL; Interventions: Drug: Aliskiren | Arm Label: Placebo; Type: PLACEBO_COMPARATOR; Interventions: Drug: Placebo | Intervention Type: DRUG; Name: Aliskiren; Assigned to Arm(s): Aliskiren | Intervention Type: DRUG; Name: Placebo; Assigned to Arm(s): Placebo
B: Arm Label: Chlorthalidone plus amiloride; Type: ACTIVE_COMPARATOR; Interventions: Drug: Chlorthalidone plus amiloride | Arm Label: losartan; Type: EXPERIMENTAL; Interventions: Drug: losartan | Intervention Type: DRUG; Name: losartan; Assigned to Arm(s): losartan | Intervention Type: DRUG; Name: Chlorthalidone plus amiloride; Assigned to Arm(s): Chlorthalidone plus amiloride
C: Intervention Type: DRUG; Name: Telmisartan; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: Combination of Telmisartan and Ramipril; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: Ramipril; Assigned to Arm(s): N/A
D: Arm Label: Combination Therapy; Type: EXPERIMENTAL; Interventions: Drug: Losartan and hydrochlorothiazide | Arm Label: Monotherapy; Type: ACTIVE_COMPARATOR; Interventions: Drug: Hydrochlorothiazide switched over with Losartan at 8 weeks | Intervention Type: DRUG; Name: Losartan and hydrochlorothiazide; Assigned to Arm(s): Combination Therapy | Intervention Type: DRUG; Name: Hydrochlorothiazide switched over with Losartan at 8 weeks; Assigned to Arm(s): Monotherapy

Answer: B
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: A Comparison Between Diuretics and Angiotensin-receptor Blocker Agents in Patients With Stage I Hypertension: PREVER-treatment Study
Brief Summary: High blood pressure is the major risk factor for Cardiovascular disease (CVD). The prevalence of hypertension in Brazil was established in population-based studies conducted in different cities and States, varying from 22.3 to 44% of adults.

The benefit of drug treatment of hypertension to prevent major cardiovascular events was consistently demonstrated in a large series of clinical trials controlled by placebo.

Diuretics are at least as efficacious as other blood pressure-lowering drugs, are well tolerated, have longer duration of action and the advantage of very low cost to be used in a population intervention. Chlorthalidone is the more efficacious agent. Its main limitation is to induce hypokalemia in a proportion of patients, an adverse effect that can be antagonized by a potassium-sparing diuretic, as amiloride.

A study comparing diuretic with an ARB agent is therefore recommendable in Brazil, in order to support the decisions of the Health Secretary in regard to blood pressure agents supply for the Brazilian population. Such a study was demanded and funded by the Health and Technology Ministries in Brazil.


Options:
A: Arm Label: Aliskiren + Amlodipine; Type: EXPERIMENTAL; Interventions: Drug: Amlodipine, Drug: hydrochlorothiazide, Drug: Aliskiren | Arm Label: Aliskiren Start - Amlodipine Add-On; Type: EXPERIMENTAL; Interventions: Drug: Amlodipine, Drug: hydrochlorothiazide, Drug: Aliskiren | Arm Label: Amlodipine Start- Aliskiren Add-On; Type: EXPERIMENTAL; Interventions: Drug: Amlodipine, Drug: hydrochlorothiazide, Drug: Aliskiren | Intervention Type: DRUG; Name: Amlodipine; Assigned to Arm(s): Aliskiren + Amlodipine, Aliskiren Start - Amlodipine Add-On, Amlodipine Start- Aliskiren Add-On | Intervention Type: DRUG; Name: hydrochlorothiazide; Assigned to Arm(s): Aliskiren + Amlodipine, Aliskiren Start - Amlodipine Add-On, Amlodipine Start- Aliskiren Add-On | Intervention Type: DRUG; Name: Aliskiren; Assigned to Arm(s): Aliskiren + Amlodipine, Aliskiren Start - Amlodipine Add-On, Amlodipine Start- Aliskiren Add-On
B: Arm Label: Chlorthalidone plus amiloride; Type: ACTIVE_COMPARATOR; Interventions: Drug: Chlorthalidone plus amiloride | Arm Label: losartan; Type: EXPERIMENTAL; Interventions: Drug: losartan | Intervention Type: DRUG; Name: losartan; Assigned to Arm(s): losartan | Intervention Type: DRUG; Name: Chlorthalidone plus amiloride; Assigned to Arm(s): Chlorthalidone plus amiloride
C: Intervention Type: DRUG; Name: Telmisartan; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: Combination of Telmisartan and Ramipril; Assigned to Arm(s): N/A | Intervention Type: DRUG; Name: Ramipril; Assigned to Arm(s): N/A
D: Intervention Type: DRUG; Name: Delapril, Delapril-Manidipine Fixed combination; Assigned to Arm(s): N/A

Answer: B
Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Structured Management of Patients With Suspicion of Appendicitis Using a Clinical Score and Selective Imaging
Brief Summary: Patients with acute abdominal pain and suspicion of appendicitis are common. The management of these patients is controversial with large variations between hospitals. The clinical diagnosis is regarded as insufficient necessitating the use of diagnostic techniques like ultrasound, computerized tomography and diagnostic laparoscopy. However, the role of these diagnostic techniques is not clear.

This aim of this prospective interventional study is to analyze the impact of the implementation of a clinical score to improve the clinical diagnosis and to serve as a basis for a structured management of these patients by comparison of the results after the implementation of the score with that of a baseline period. In the group of patients with indeterminate diagnosis according to the clinical score, the value of diagnostic imaging will be evaluated and compared with a period of in-hospital observation by randomization. The hypothesis is that a clinical score will decrease the use of unnecessary diagnostic imaging and unnecessary admissions to hospital for observation.


Options:
A: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Other: Omnipaque | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Other: Omnipaque | Intervention Type: OTHER; Name: Omnipaque; Assigned to Arm(s): 1, 2
B: Arm Label: Operative treatment; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Appendicectomy | Arm Label: Antibiotic treatment; Type: ACTIVE_COMPARATOR; Interventions: Drug: Ertapenem | Intervention Type: PROCEDURE; Name: Appendicectomy; Assigned to Arm(s): Operative treatment | Intervention Type: DRUG; Name: Ertapenem; Assigned to Arm(s): Antibiotic treatment
C: Arm Label: A; Type: ACTIVE_COMPARATOR; Interventions: Procedure: appendectomy | Arm Label: B; Type: ACTIVE_COMPARATOR; Interventions: Drug: amoxicillin/clavulanate potassium | Intervention Type: DRUG; Name: amoxicillin/clavulanate potassium; Assigned to Arm(s): B | Intervention Type: PROCEDURE; Name: appendectomy; Assigned to Arm(s): A
D: Arm Label: Diagnostic imaging; Type: EXPERIMENTAL; Interventions: Procedure: Diagnostic imaging | Arm Label: Repeat examination after observation; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Diagnostic imaging | Intervention Type: PROCEDURE; Name: Diagnostic imaging; Assigned to Arm(s): Diagnostic imaging, Repeat examination after observation

Answer: D