Please select the eligibility criteria that correspond to the clinical trial below.
Title: Use of Pathological Phenotype to Determine Optimal Management for Moderate to Severe Preschool Wheeze
Brief Summary: This is a single-centre, randomised-controlled trial, comparing management of preschool wheeze. It specifically aims to compare management of preschool wheeze using current clinical guidelines to management determined by eosinophilic inflammation and infection. Participants will be children aged 1-5 years who have recurrent wheezing and will be allocated to one of two treatment groups, either current clinical care or pathological phenotype based management. They will be asked to make 2 study visits to the Royal Brompton Hospital over the course of 4 months.


Options:
A: Inclusion Criteria:

* Reported recurrent wheeze, needing at least 2 courses of oral steroids in the last 12 months, at least one course of oral steroids in the last 6 months
* Past wheeze confirmed by a clinician

Exclusion Criteria:

* Any known cardiac disease
* Any chronic respiratory condition (other than preschool wheeze) diagnosed by a physician
* Any chronic condition that increases susceptibility to respiratory tract infections such as severe developmental delay and feeding difficulty/unsafe swallow Prematurity \<34 weeks, or requirement of ventilation in the newborn period History of neonatal chronic lung disease Family not contactable by telephone
B: Inclusion Criteria:

* provider-diagnosed persistent asthma
* prescription of an ICS in accordance in NHLBI Expert Panel Report 3 guidelines for at least 30 days prior to enrollment
* Asthma Control Test (ACT) score less than 20 (indicating lack of current control)
* no provider-diagnosed exacerbation in the 30 days prior to enrollment
* possession of a text-enabled cell phone and a plan to keep it throughout the study period
* agreement by parents (or participants over 18 years old) to any charges levied by their cell phone carrier for text messages associated with the study if they do not have an unlimited texting plan
* speak and read English

Exclusion Criteria:

* another chronic lung disease (which would complicate measurement of asthma control)
* cognitive or psychiatric disorder that the treating clinician judges would impair study participation
* use of Advair diskus for their ICS (for which no reliable electronic monitor exists)
* current enrollment in another asthma intervention study
C: Inclusion Criteria:

* Physician diagnosis of persistent asthma defined by treatment with at least one daily controller medication
* Fluent English speaking
* Subject must have access to an iOS or Android device in order to download and use the mobile health application
* At least one Emergency Department or Urgent Care visit due to asthma exacerbation in the 12 months prior to enrollment

Exclusion Criteria:

* No prescription/recommendation to use a daily controller medication
* Non-English speaking
* Lack of access to an iOS or Android device
* Current or prior use of AsthmaCare mobile health application at any time. Research assistant will assess by reviewing beforehand a complete list of people who have already downloaded the app
D: Inclusion Criteria:

1. patients having mild or moderate persistent asthma
2. 6 months-3 years
3. taking regular inhaled steroids, with no change in their medication in the last month.

Exclusion Criteria:

Participants who had severe persistent asthma or another respiratory disease or did not live in Shanghai were excluded.

Answer: A