Please select the eligibility criteria that correspond to the clinical trial below.
Title: Pilot Study of the Effect of Hyperbaric Oxygen Treatment on Behavioral and Biomarker Measures in Children With Autism
Brief Summary: The purpose of this study is to increase the understanding of the effect of Hyperbaric Oxygen Treatment (HBOT) on the behavior and functioning of children with autism. The main goal of this study is to demonstrate that HBOT is safe and tolerable in autistic children, and to measure the effect of HBOT on specific chemicals in their blood that may play a role in the child's behavior.


Options:
A: Inclusion Criteria:

* Male and female children 2-10 years diagnosed with autism, PDD, or Aspergers
* No anticipated changes in treatment for the study duration (e.g., diet, nutrients)
* No additional biomedical treatments started 6 weeks prior to enrollment
* No changes in dietary management for 3 months prior to enrollment
* Access to Thoughtful House on a daily basis, or as necessary for the study participation
* In addition, the child participant must be:

  * Ambulatory or require minimum support walking, per parent
  * Able to sit still for 5 minutes or longer with a preferred toy item, per parent
  * Adequate vision and hearing for the purposes of test administration, per parent
  * Adequate arm-hand-finger coordination (i.e., able to point) for learning and cognitive tasks used in outcome measurement, per parent
  * Stable and controlled medical disorder
  * Under the care of a caregiver willing to participate by attending regularly scheduled appointments and completing the necessary measures
B: Inclusion Criteria:

* Age 18 years or older, who had ischemic stroke and 60 patients who had hemorrhagic stroke 6-18 months prior to their inclusion in the study.

Exclusion Criteria:

* Dynamic neurologic improvement or worsening during the last 4 weeks.
* Had been treated with HBO for any other reason prior to their inclusion.
* Have any other indication for HBOT
* Chest pathology incompatible with pressure changes
* Inner ear disease
* Patients suffering from claustrophobia.
* Inability to give written informed consent.
C: Inclusion Criteria:

* DSM-IV diagnosis of Autistic Disorder, confirmed with Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
* HBOT naïve

Exclusion Criteria:

* DSM-IV diagnosis of Pervasive Developmental Disorder other than Autistic Disorder including PDD-NOS (Pervasive Developmental Disorder, not otherwise specified) and Asperger's Syndrome
* Uncontrolled seizures
* Ear infection
* Uncontrolled asthma
* Inability to equalize ear pressure
* Fragile X syndrome
* Current therapy consisting of chelation
D: Inclusion Criteria:

1. Diagnosis of DSM-IV defined autism and meets cut off for autism on the Autism Diagnostic Inventory-Revised (ADI-R) or Social Communication Questionnaire (SCQ) and the Autism Diagnostic Observation Scale (ADOS).
2. Age 3 to 8 years.
3. Nonverbal IQ of 50 or above.
4. Parental agreement to continue present dietary, behavioral or psychotropic drug treatment but not change treatment during 20 week intervention.

Exclusion Criteria:

1. Clinical evidence of seizure disorder
2. Active infection with fever
3. Fragile X or other known genetic cause of autism
4. Perinatal brain injury (e.g. cerebral palsy)
5. Previous adequate trial (at least 20 session) of HBOT
6. Inability to clear ears in the HBOT chambers

Answer: D