Please select the arm or intervention descriptions that belong to the clinical trial below.
Title: Duration of Red Blood Cell Storage Prior to Transfusion and Non-Transferrin-Bound Iron
Brief Summary: This study will determine the minimal duration of red blood cell (RBC) storage that leads to increases in circulating non-transferrin-bound iron in healthy human volunteers post-transfusion. The results from this study will help guide national guidelines for appropriate duration of RBC storage prior to transfusion, which is currently 6 weeks by Food and Drug Administration (FDA) criteria. The overall objective of this research is to improve the safety of refrigerated storage of red blood cells before transfusion.


Options:
A: Arm Label: Short storage; Type: EXPERIMENTAL; Interventions: Biological: Blood transfusion | Arm Label: Long storage arm; Type: ACTIVE_COMPARATOR; Interventions: Biological: Blood transfusion | Intervention Type: BIOLOGICAL; Name: Blood transfusion; Assigned to Arm(s): Long storage arm, Short storage
B: Arm Label: Short-storage RBC; Type: ACTIVE_COMPARATOR; Interventions: Biological: RBC transfusion | Arm Label: Prolonged-storage RBC; Type: ACTIVE_COMPARATOR; Interventions: Biological: RBC transfusion | Intervention Type: BIOLOGICAL; Name: RBC transfusion; Assigned to Arm(s): Prolonged-storage RBC, Short-storage RBC
C: Arm Label: Transfusion of PRBC stored for 1 week; Type: ACTIVE_COMPARATOR; Interventions: Procedure: Blood Transfusion, Other: Packed red blood cells | Arm Label: Transfusion of PRBC stored for 2 weeks; Type: EXPERIMENTAL; Interventions: Procedure: Blood Transfusion, Other: Packed red blood cells | Arm Label: Transfusion of PRBC stored for 3 weeks; Type: EXPERIMENTAL; Interventions: Procedure: Blood Transfusion, Other: Packed red blood cells | Arm Label: Transfusion of PRBC stored for 4 weeks; Type: EXPERIMENTAL; Interventions: Procedure: Blood Transfusion, Other: Packed red blood cells | Arm Label: Transfusion of PRBC stored for 5 weeks; Type: EXPERIMENTAL; Interventions: Procedure: Blood Transfusion, Other: Packed red blood cells | Arm Label: Transfusion of PRBC stored for 6 weeks; Type: EXPERIMENTAL; Interventions: Procedure: Blood Transfusion, Other: Packed red blood cells | Intervention Type: PROCEDURE; Name: Blood Transfusion; Assigned to Arm(s): Transfusion of PRBC stored for 1 week, Transfusion of PRBC stored for 2 weeks, Transfusion of PRBC stored for 3 weeks, Transfusion of PRBC stored for 4 weeks, Transfusion of PRBC stored for 5 weeks, Transfusion of PRBC stored for 6 weeks | Intervention Type: OTHER; Name: Packed red blood cells; Assigned to Arm(s): Transfusion of PRBC stored for 1 week, Transfusion of PRBC stored for 2 weeks, Transfusion of PRBC stored for 3 weeks, Transfusion of PRBC stored for 4 weeks, Transfusion of PRBC stored for 5 weeks, Transfusion of PRBC stored for 6 weeks
D: Arm Label: 1; Type: ACTIVE_COMPARATOR; Interventions: Other: RBC transfusion of 5 days or less storage age | Arm Label: 2; Type: ACTIVE_COMPARATOR; Interventions: Other: RBC transfusion of conventional storage age | Intervention Type: OTHER; Name: RBC transfusion of 5 days or less storage age; Assigned to Arm(s): 1 | Intervention Type: OTHER; Name: RBC transfusion of conventional storage age; Assigned to Arm(s): 2

Answer: C