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Black Death
The Black Death (also known as the Pestilence, the Great Mortality or the Plague) was a bubonic plague pandemic occurring in Western Eurasia and North Africa from 1346 to 1353. It is the most fatal pandemic recorded in human history, causing the deaths of 75–200 million people, peaking in Europe from 1347 to 1351. Bubonic plague is caused by the bacterium Yersinia pestis spread by fleas, but during the Black Death it probably also took a secondary form, spread by person-to-person contact via aerosols, causing pneumonic plague.The Black Death was the beginning of the second plague pandemic. The plague created religious, social and economic upheavals, with profound effects on the course of European history.
The origin of the Black Death is disputed. Genetic analysis points to the evolution of Yersinia pestis in the Tian Shan mountains on the border between Kyrgyzstan and China 2,600 years ago. The immediate territorial origins of the Black Death and its outbreak remains unclear with some pointing towards Central Asia, China, the Middle East and Europe. The pandemic was reportedly first introduced to Europe during the siege of the Genoese trading port of Kaffa in Crimea by the Golden Horde army of Jani Beg in 1347. From Crimea, it was most likely carried by fleas living on the black rats that travelled on Genoese ships, spreading through the Mediterranean Basin and reaching North Africa, Western Asia and the rest of Europe via Constantinople, Sicily and the Italian Peninsula. There is evidence that once it came ashore, the Black Death mainly spread person-to-person as pneumonic plague, thus explaining the quick inland spread of the epidemic, which was faster than would be expected if the primary vector was rat fleas causing bubonic plague. In 2022, it was discovered that there was a sudden surge of deaths in what is today Kyrgyzstan from the Black Death in the late 1330s; when combined with genetic evidence, this implies that the initial spread may not have been due to Mongol conquests in the 14th century, as previously speculated.The Black Death was the second great natural disaster to strike Europe during the Late Middle Ages (the first one being the Great Famine of 1315–1317) and is estimated to have killed 30 percent to 60 percent of the European population, as well as about one-third of the population of the Middle East. The plague might have reduced the world population from c. 475 million to 350–375 million in the 14th century. There were further outbreaks throughout the Late Middle Ages and, with other contributing factors (the Crisis of the Late Middle Ages), the European population did not regain its level in 1300 until 1500. Outbreaks of the plague recurred around the world until the early 19th century.

Names
European writers contemporary with the plague described the disease in Latin as pestis or pestilentia, 'pestilence'; epidemia, 'epidemic'; mortalitas, 'mortality'. In English prior to the 18th century, the event was called the "pestilence" or "great pestilence", "the plague" or the "great death". Subsequent to the pandemic "the furste moreyn" (first murrain) or "first pestilence" was applied, to distinguish the mid-14th century phenomenon from other infectious diseases and epidemics of plague.The 1347 pandemic plague was not referred to specifically as "black" in the time of occurrence in any European language, though the expression "black death" had occasionally been applied to fatal disease beforehand. "Black death" was not used to describe the plague pandemic in English until the 1750s; the term is first attested in 1755, where it translated Danish: den sorte død, lit. 'the black death'. This expression as a proper name for the pandemic had been popularized by Swedish and Danish chroniclers in the 15th and early 16th centuries, and in the 16th and 17th centuries was transferred to other languages as a calque: Icelandic: svarti dauði, German: der schwarze Tod, and French: la mort noire. Previously, most European languages had named the pandemic a variant or calque of the Latin: magna mortalitas, lit. 'Great Death'.The phrase 'black death' – describing Death as black – is very old. Homer used it in the Odyssey to describe the monstrous Scylla, with her mouths "full of black Death" (Ancient Greek: πλεῖοι μέλανος Θανάτοιο, romanized: pleîoi mélanos Thanátoio). Seneca the Younger may have been the first to describe an epidemic as 'black death', (Latin: mors atra) but only in reference to the acute lethality and dark prognosis of disease. The 12th–13th century French physician Gilles de Corbeil had already used atra mors to refer to a "pestilential fever" (febris pestilentialis) in his work On the Signs and Symptoms of Diseases (De signis et symptomatibus aegritudium). The phrase mors nigra, 'black death', was used in 1350 by Simon de Covino (or Couvin), a Belgian astronomer, in his poem "On the Judgement of the Sun at a Feast of Saturn" (De judicio Solis in convivio Saturni), which attributes the plague to an astrological conjunction of Jupiter and Saturn. His use of the phrase is not connected unambiguously with the plague pandemic of 1347 and appears to refer to the fatal outcome of disease.The historian Cardinal Francis Aidan Gasquet wrote about the Great Pestilence in 1893 and suggested that it had been "some form of the ordinary Eastern or bubonic plague". In 1908, Gasquet said use of the name atra mors for the 14th-century epidemic first appeared in a 1631 book on Danish history by J. I. Pontanus: "Commonly and from its effects, they called it the black death" (Vulgo & ab effectu atram mortem vocitabant).

Previous plague epidemics
Research from 2017 suggests plague first infected humans in Europe and Asia in the Late Neolithic-Early Bronze Age. Research in 2018 found evidence of Yersinia pestis in an ancient Swedish tomb, which may have been associated with the "Neolithic decline" around 3000 BCE, in which European populations fell significantly. This Y. pestis may have been different from more modern types, with bubonic plague transmissible by fleas first known from Bronze Age remains near Samara.The symptoms of bubonic plague are first attested in a fragment of Rufus of Ephesus preserved by Oribasius; these ancient medical authorities suggest bubonic plague had appeared in the Roman Empire before the reign of Trajan, six centuries before arriving at Pelusium in the reign of Justinian I. In 2013, researchers confirmed earlier speculation that the cause of the Plague of Justinian (541–542 CE, with recurrences until 750) was Y. pestis. This is known as the first plague pandemic. In 610, the Chinese physician Chao Yuanfang described a "malignant bubo" "coming in abruptly with high fever together with the appearance of a bundle of nodes beneath the tissue." The Chinese physician Sun Simo who died in 652 also mentioned a "malignant bubo" and plague that was common in Lingnan (Guangzhou). Ole Jørgen Benedictow believes that this indicates it was an offshoot of the first plague pandemic which made its way eastward to Chinese territory by around 600.

14th-century plague
Causes
Early theory
The most authoritative contemporary account is found in a report from the medical faculty in Paris to Philip VI of France. It blamed the heavens, in the form of a conjunction of three planets in 1345 that caused a "great pestilence in the air" (miasma theory). Muslim religious scholars taught that the pandemic was a "martyrdom and mercy" from God, assuring the believer's place in paradise. For non-believers, it was a punishment. Some Muslim doctors cautioned against trying to prevent or treat a disease sent by God. Others adopted preventive measures and treatments for plague used by Europeans. These Muslim doctors also depended on the writings of the ancient Greeks.

Predominant modern theory
Due to climate change in Asia, rodents began to flee the dried-out grasslands to more populated areas, spreading the disease. The plague disease, caused by the bacterium Yersinia pestis, is enzootic (commonly present) in populations of fleas carried by ground rodents, including marmots, in various areas, including Central Asia, Kurdistan, Western Asia, North India, Uganda and the western United States.Y. pestis was discovered by Alexandre Yersin, a pupil of Louis Pasteur, during an epidemic of bubonic plague in Hong Kong in 1894; Yersin also proved this bacillus was present in rodents and suggested the rat was the main vehicle of transmission. The mechanism by which Y. pestis is usually transmitted was established in 1898 by Paul-Louis Simond and was found to involve the bites of fleas whose midguts had become obstructed by replicating Y. pestis several days after feeding on an infected host. This blockage starves the fleas and drives them to aggressive feeding behaviour and attempts to clear the blockage by regurgitation, resulting in thousands of plague bacteria being flushed into the feeding site, infecting the host. The bubonic plague mechanism was also dependent on two populations of rodents: one resistant to the disease, which act as hosts, keeping the disease endemic, and a second that lacks resistance. When the second population dies, the fleas move on to other hosts, including people, thus creating a human epidemic.

DNA evidence
Definitive confirmation of the role of Y. pestis arrived in 2010 with a publication in PLOS Pathogens by Haensch et al. They assessed the presence of DNA/RNA with polymerase chain reaction (PCR) techniques for Y. pestis from the tooth sockets in human skeletons from mass graves in northern, central and southern Europe that were associated archaeologically with the Black Death and subsequent resurgences. The authors concluded that this new research, together with prior analyses from the south of France and Germany, "ends the debate about the cause of the Black Death, and unambiguously demonstrates that Y. pestis was the causative agent of the epidemic plague that devastated Europe during the Middle Ages". In 2011, these results were further confirmed with genetic evidence derived from Black Death victims in the East Smithfield burial site in England. Schuenemann et al. concluded in 2011 "that the Black Death in medieval Europe was caused by a variant of Y. pestis that may no longer exist".Later in 2011, Bos et al. reported in Nature the first draft genome of Y. pestis from plague victims from the same East Smithfield cemetery and indicated that the strain that caused the Black Death is ancestral to most modern strains of Y. pestis.Since this time, further genomic papers have further confirmed the phylogenetic placement of the Y. pestis strain responsible for the Black Death as both the ancestor of later plague epidemics including the third plague pandemic and as the descendant of the strain responsible for the Plague of Justinian. In addition, plague genomes from significantly earlier in prehistory have been recovered.DNA taken from 25 skeletons from 14th century London have shown plague is a strain of Y. pestis almost identical to that which hit Madagascar in 2013. Further DNA evidence also proves the role of Y. Pestis and traces the source to the Tian Shan Mountains in Kyrgyzstan.

Alternative explanations
It is recognised that an epidemiological account of plague is as important as an identification of symptoms, but researchers are hampered by the lack of reliable statistics from this period. Most work has been done on the spread of the disease in England, and even estimates of overall population at the start vary by over 100% as no census was undertaken in England between the time of publication of the Domesday Book of 1086 and the poll tax of the year 1377. Estimates of plague victims are usually extrapolated from figures for the clergy.
Mathematical modelling is used to match the spreading patterns and the means of transmission. A research in 2018 challenged the popular hypothesis that "infected rats died, their flea parasites could have jumped from the recently dead rat hosts to humans". It suggested an alternative model in which "the disease was spread from human fleas and body lice to other people". The second model claims to better fit the trends of death toll because the rat-flea-human hypothesis would have produced a delayed but very high spike in deaths, which contradict historical death data.Lars Walløe complains that all of these authors "take it for granted that Simond's infection model, black rat → rat flea → human, which was developed to explain the spread of plague in India, is the only way an epidemic of Yersinia pestis infection could spread", whilst pointing to several other possibilities. Similarly, Monica Green has argued that greater attention is needed to the range of (especially non-commensal) animals that might be involved in the transmission of plague.Archaeologist Barney Sloane has argued that there is insufficient evidence of the extinction of numerous rats in the archaeological record of the medieval waterfront in London and that the disease spread too quickly to support the thesis that Y. pestis was spread from fleas on rats; he argues that transmission must have been person to person. This theory is supported by research in 2018 which suggested transmission was more likely by body lice and fleas during the second plague pandemic.

Summary
Although academic debate continues, no single alternative solution has achieved widespread acceptance. Many scholars arguing for Y. pestis as the major agent of the pandemic suggest that its extent and symptoms can be explained by a combination of bubonic plague with other diseases, including typhus, smallpox and respiratory infections. In addition to the bubonic infection, others point to additional septicaemic (a type of "blood poisoning") and pneumonic (an airborne plague that attacks the lungs before the rest of the body) forms of plague, which lengthen the duration of outbreaks throughout the seasons and help account for its high mortality rate and additional recorded symptoms. In 2014, Public Health England announced the results of an examination of 25 bodies exhumed in the Clerkenwell area of London, as well as of wills registered in London during the period, which supported the pneumonic hypothesis. Currently, while osteoarcheologists have conclusively verified the presence of Y. pestis bacteria in burial sites across northern Europe through examination of bones and dental pulp, no other epidemic pathogen has been discovered to bolster the alternative explanations.

Transmission
Lack of hygiene
The importance of hygiene was recognised only in the nineteenth century with the development of the germ theory of disease; until then streets were commonly filthy, with live animals of all sorts around and human parasites abounding, facilitating the spread of transmissible disease.By the early fourteenth century so much filth had collected inside urban Europe that French and Italian cities were naming streets after human waste. In medieval Paris, several street names were inspired by merde, the French word for "shit". There were rue Merdeux, rue Merdelet, rue Merdusson, rue des Merdons and rue Merdiere—as well as a rue du Pipi.Pigs, cattle, chickens, geese, goats and horses roamed the streets of medieval London and Paris. Medieval homeowners were supposed to police their housefronts, including removing animal dung, but most urbanites were as careless as William E. Cosner, a resident of the London suburb of Farringdon Without. A complaint lodged against Cosner charges that "men could not pass [by his house] for the stink [of] . . . horse dung and horse piss."One irate Londoner complained that the runoff from the local slaughterhouse had made his garden "stinking and putrid", while another charged that the blood from slain animals flooded nearby streets and lanes, "making a foul corruption and abominable sight to all dwelling near." In much of medieval Europe, sanitation legislation consisted of an ordinance requiring homeowners to shout, "Look out below!" three times before dumping a full chamber pot into the street.Early Christians, who thought self-abnegation a cardinal virtue, considered bathing, if not a vice, then a temptation. "Who knows what impure thoughts might arise in a tub of warm water? With this danger in mind, St. Benedict declared, "To those who are well, and especially to the young, bathing shall seldom be permitted." St. Agnes took the injunction to heart and died without ever bathing.

Territorial origins
According to a team of medical geneticists led by Mark Achtman that analysed the genetic variation of the bacterium Yersinia pestis "evolved in or near China" over 2,600 years ago. Later research by a team led by Galina Eroshenko places the origins more specifically in the Tian Shan mountains on the border between Kyrgyzstan and China. However more recent research notes that the previous sampling had a very heavy East Asian bias and that sampling since then has discovered strains of Y. pestis in the Caucasus region that were previously thought to be restricted to China. There is also no physical or specific textual evidence of the Black Death in 14th century China. As a result, China's place in the sequence of the plague's spread is still debated to this day. According to Charles Creighton, records of epidemics in 14th century China suggest nothing more than typhus and major Chinese outbreaks of epidemic disease post-date the European epidemic by several years. The earliest Chinese descriptions of the bubonic plague do not appear until the 1640s.Nestorian graves dating to 1338–1339 near Issyk-Kul in Kyrgyzstan have inscriptions referring to plague, which has led some historians and epidemiologists to think they mark the outbreak of the epidemic; this is supported by recent direct findings of Y. pestis DNA in teeth samples from graves in the area with inscriptions referring to "pestilence" as the cause of death. Epidemics killed an estimated 25 million across Asia during the fifteen years before the Black Death reached Constantinople in 1347.
The evidence does not suggest, at least at present, that these mortality crises were caused by plague. Although some scholars, including McNeill and Cao, see the 1333 outbreak as a prelude to the outbreaks in Europe from the late 1340s to the early 1350s, scholars of the Yuan and Ming periods remain skeptical about such an interpretation. Nonetheless, the remarkably high mortality rates during the Datong mortality should discourage us from rejecting the possibility of localized/regional outbreaks of plague in different parts of China, albeit differing in scale from, and unrelated to, the pandemic mortality of the Black Death. What we lack is any indication of a plague pandemic that engulfed vast territories of the Yuan Empire and later moved into western Eurasia through Central Asia.
According to John Norris, evidence from Issyk-Kul indicates a small sporadic outbreak characteristic of transmission from rodents to humans with no wide-scale impact. According to Achtman, the dating of the plague suggests that it was not carried along the Silk Road, and its widespread appearance in that region probably postdates the European outbreak. There are no records of the symptoms of the Black Death from Mongol sources or writings from travelers east of the Black Sea prior to the Crimean outbreak in 1346. Finally, the Silk Road had already been heavily disrupted before the spread of the Black Death. Western and Middle Eastern traders found it difficult to trade on the Silk Road by 1325 and impossible by 1340, making spread of the plague less likely.Others still favor an origin in China or even Kurdistan, and not Central Asia. According to the theory of Chinese origin, the disease may have traveled along the Silk Road with Mongol armies and traders, or it could have arrived via ship, but this theory is still contested. It is speculated that rats aboard Zheng He's ships in the 15th century may have carried the plague to Southeast Asia, India and Africa.
Research on the Delhi Sultanate and the Yuan Dynasty shows no evidence of any serious epidemic in fourteenth-century India and no specific evidence of plague in fourteenth-century China, suggesting that the Black Death may not have reached these regions. Ole Benedictow argues that since the first clear reports of the Black Death come from Kaffa, the Black Death most likely originated in the nearby plague focus on the northwestern shore of the Caspian Sea.
Demographic historians estimate that China's population fell by at least 15 percent, and perhaps as much as a third, between 1340 and 1370. This population loss coincided with the Black Death that ravaged Europe and much of the Islamic world in 1347–52. However, there is a conspicuous lack of evidence for pandemic disease on the scale of the Black Death in China at this time. War and famine – and the diseases that typically accompanied them – probably were the main causes of mortality in the final decades of Mongol rule.
Monica H. Green suggests that the reason why other parts of Eurasia outside the west do not contain the same evidence of the Black Plague is because there were actually four strains of Yersinia pestis that became predominant in different parts of the world. Mongol records of illness such as food poisoning may have been referring to the Black Plague. Another theory is that the Black Death originated near Europe and cycled through the Mediterranean, Northern Europe and Russia before making its way to China. Other historians such as John Norris and Ole Benedictaw believe the Black Death likely originated in Europe or the Middle East and never reached China.

European outbreak
Plague was reportedly first introduced to Europe via Genoese traders from their port city of Kaffa in the Crimea in 1347. During a protracted siege of the city, in 1345–1346 the Mongol Golden Horde army of Jani Beg, whose mainly Tatar troops were suffering from the disease, catapulted infected corpses over the city walls of Kaffa to infect the inhabitants, though it is more likely that infected rats travelled across the siege lines to spread the epidemic to the inhabitants. As the disease took hold, Genoese traders fled across the Black Sea to Constantinople, where the disease first arrived in Europe in summer 1347.The epidemic there killed the 13-year-old son of the Byzantine emperor, John VI Kantakouzenos, who wrote a description of the disease modelled on Thucydides's account of the 5th century BCE Plague of Athens, but noting the spread of the Black Death by ship between maritime cities. Nicephorus Gregoras also described in writing to Demetrios Kydones the rising death toll, the futility of medicine, and the panic of the citizens. The first outbreak in Constantinople lasted a year, but the disease recurred ten times before 1400.Carried by twelve Genoese galleys, plague arrived by ship in Sicily in October 1347; the disease spread rapidly all over the island. Galleys from Kaffa reached Genoa and Venice in January 1348, but it was the outbreak in Pisa a few weeks later that was the entry point to northern Italy. Towards the end of January, one of the galleys expelled from Italy arrived in Marseilles.From Italy, the disease spread northwest across Europe, striking France, Spain (the epidemic began to wreak havoc first on the Crown of Aragon in the spring of 1348), Portugal and England by June 1348, then spread east and north through Germany, Scotland and Scandinavia from 1348 to 1350. It was introduced into Norway in 1349 when a ship landed at Askøy, then spread to Bjørgvin (modern Bergen) and Iceland. Finally, it spread to northwestern Russia in 1351. Plague was somewhat more uncommon in parts of Europe with less developed trade with their neighbours, including the majority of the Basque Country, isolated parts of Belgium and the Netherlands, and isolated Alpine villages throughout the continent.According to some epidemiologists, periods of unfavourable weather decimated plague-infected rodent populations and forced their fleas onto alternative hosts, inducing plague outbreaks which often peaked in the hot summers of the Mediterranean, as well as during the cool autumn months of the southern Baltic region. Among many other culprits of plague contagiousness, malnutrition, even if distantly, also contributed to such an immense loss in European population, since it weakened immune systems.

Western Asian and North African outbreak
The disease struck various regions in the Middle East and North Africa during the pandemic, leading to serious depopulation and permanent change in both economic and social structures. As infected rodents infected new rodents, the disease spread across the region, entering also from southern Russia.
By autumn 1347, plague had reached Alexandria in Egypt, transmitted by sea from Constantinople; according to a contemporary witness, from a single merchant ship carrying slaves. By late summer 1348 it reached Cairo, capital of the Mamluk Sultanate, cultural centre of the Islamic world, and the largest city in the Mediterranean Basin; the Bahriyya child sultan an-Nasir Hasan fled and more than a third of the 600,000 residents died. The Nile was choked with corpses despite Cairo having a medieval hospital, the late 13th century bimaristan of the Qalawun complex. The historian al-Maqrizi described the abundant work for grave-diggers and practitioners of funeral rites, and plague recurred in Cairo more than fifty times over the following one and a half centuries.During 1347, the disease travelled eastward to Gaza by April; by July it had reached Damascus, and in October plague had broken out in Aleppo. That year, in the territory of modern Lebanon, Syria, Israel and Palestine, the cities of Ascalon, Acre, Jerusalem, Sidon and Homs were all infected. In 1348–1349, the disease reached Antioch. The city's residents fled to the north, but most of them ended up dying during the journey. Within two years, the plague had spread throughout the Islamic world, from Arabia across North Africa. The pandemic spread westwards from Alexandria along the African coast, while in April 1348 Tunis was infected by ship from Sicily. Tunis was then under attack by an army from Morocco; this army dispersed in 1348 and brought the contagion with them to Morocco, whose epidemic may also have been seeded from the Islamic city of Almería in al-Andalus.Mecca became infected in 1348 by pilgrims performing the Hajj. In 1351 or 1352, the Rasulid sultan of the Yemen, al-Mujahid Ali, was released from Mamluk captivity in Egypt and carried plague with him on his return home. During 1348, records show the city of Mosul suffered a massive epidemic, and the city of Baghdad experienced a second round of the disease.

Signs and symptoms
Bubonic plague
Symptoms of the disease include fever of 38–41 °C (100–106 °F), headaches, painful aching joints, nausea and vomiting, and a general feeling of malaise. Left untreated, of those that contract the bubonic plague, 80 percent die within eight days.Contemporary accounts of the pandemic are varied and often imprecise. The most commonly noted symptom was the appearance of buboes (or gavocciolos) in the groin, neck and armpits, which oozed pus and bled when opened. Boccaccio's description:

In men and women alike it first betrayed itself by the emergence of certain tumours in the groin or armpits, some of which grew as large as a common apple, others as an egg ... From the two said parts of the body this deadly gavocciolo soon began to propagate and spread itself in all directions indifferently; after which the form of the malady began to change, black spots or livid making their appearance in many cases on the arm or the thigh or elsewhere, now few and large, now minute and numerous. As the gavocciolo had been and still was an infallible token of approaching death, such also were these spots on whomsoever they showed themselves.
This was followed by acute fever and vomiting of blood. Most people died two to seven days after initial infection. Freckle-like spots and rashes, which could have been caused by flea-bites, were identified as another potential sign of plague.

Pneumonic plague
Lodewijk Heyligen, whose master the Cardinal Colonna died of plague in 1348, noted a distinct form of the disease, pneumonic plague, that infected the lungs and led to respiratory problems. Symptoms include fever, cough and blood-tinged sputum. As the disease progresses, sputum becomes free-flowing and bright red. Pneumonic plague has a mortality rate of 90 to 95 percent.

Septicaemic plague
Septicaemic plague is the least common of the three forms, with a mortality rate near 100%. Symptoms are high fevers and purple skin patches (purpura due to disseminated intravascular coagulation). In cases of pneumonic and particularly septicaemic plague, the progress of the disease is so rapid that there would often be no time for the development of the enlarged lymph nodes that were noted as buboes.

Consequences
Deaths
There are no exact figures for the death toll; the rate varied widely by locality. In urban centres, the greater the population before the outbreak, the longer the duration of the period of abnormal mortality. It killed some 75 to 200 million people in Eurasia. A study published in 2022 of pollen samples across Europe between 1250 and 1450 was used to estimate changes in agricultural output before and after the Black Death. The authors found great variability in different regions, with evidence for high mortality in areas of Scandinavia, France, western Germany, Greece and central Italy, but uninterrupted agricultural growth in central and eastern Europe, Iberia and Ireland.The mortality rate of the Black Death in the 14th century was far greater than the worst 20th-century outbreaks of Y. pestis plague, which occurred in India and killed as much as 3% of the population of certain cities. The overwhelming number of deceased bodies produced by the Black Death caused the necessity of mass burial sites in Europe, sometimes including up to several hundred or several thousand skeletons. The mass burial sites that have been excavated have allowed archaeologists to continue interpreting and defining the biological, sociological, historical and anthropological implications of the Black Death.According to medieval historian Philip Daileader, it is likely that over four years, 45–50% of the European population died of plague. Norwegian historian Ole Benedictow suggests it could have been as much as 60% of the European population. In 1348, the disease spread so rapidly that before any physicians or government authorities had time to reflect upon its origins, about a third of the European population had already perished. In crowded cities, it was not uncommon for as much as 50% of the population to die. Half of Paris' population of 100,000 people died. In Italy, the population of Florence was reduced from between 110,000 and 120,000 inhabitants in 1338 down to 50,000 in 1351. At least 60% of the population of Hamburg and Bremen perished, and a similar percentage of Londoners may have died from the disease as well, with a death toll of approximately 62,000 between 1346 and 1353. Florence's tax records suggest that 80% of the city's population died within four months in 1348. Before 1350, there were about 170,000 settlements in Germany, and this was reduced by nearly 40,000 by 1450. The disease bypassed some areas, with the most isolated areas being less vulnerable to contagion. Plague did not appear in Douai in Flanders until the turn of the 15th century, and the impact was less severe on the populations of Hainaut, Finland, northern Germany and areas of Poland. Monks, nuns and priests were especially hard-hit since they cared for people with the Black Death.

The physician to the Avignon Papacy, Raimundo Chalmel de Vinario (Latin: Magister Raimundus, lit. 'Master Raymond'), observed the decreasing mortality rate of successive outbreaks of plague in 1347–48, 1362, 1371 and 1382 in his 1382 treatise On Epidemics (De epidemica). In the first outbreak, two thirds of the population contracted the illness and most patients died; in the next, half the population became ill but only some died; by the third, a tenth were affected and many survived; while by the fourth occurrence, only one in twenty people were sickened and most of them survived. By the 1380s in Europe, it predominantly affected children. Chalmel de Vinario recognised that bloodletting was ineffective (though he continued to prescribe bleeding for members of the Roman Curia, whom he disliked), and said that all true cases of plague were caused by astrological factors and were incurable; he himself was never able to effect a cure.The most widely accepted estimate for the Middle East, including Iraq, Iran and Syria, during this time, is for a death toll of about a third of the population. The Black Death killed about 40% of Egypt's population. In Cairo, with a population numbering as many as 600,000, and possibly the largest city west of China, between one third and 40% of the inhabitants died within eight months.Italian chronicler Agnolo di Tura recorded his experience from Siena, where plague arrived in May 1348:

Father abandoned child, wife husband, one brother another; for this illness seemed to strike through the breath and sight. And so they died. And none could be found to bury the dead for money or friendship. Members of a household brought their dead to a ditch as best they could, without priest, without divine offices ... great pits were dug and piled deep with the multitude of dead. And they died by the hundreds both day and night ... And as soon as those ditches were filled more were dug ... And I, Agnolo di Tura ... buried my five children with my own hands. And there were also those who were so sparsely covered with earth that the dogs dragged them forth and devoured many bodies throughout the city. There was no one who wept for any death, for all awaited death. And so many died that all believed it was the end of the world.

Economic
It has been suggested that the plague, like some others in history, disproportionately affected the poorest people, who were already in generally worse physical condition than the wealthier citizens.  Nevertheless, with such a large overall population decline from the pandemic, wages soared in response to a labour shortage. On the other hand, in the quarter century after the Black Death in England, it is clear many labourers, artisans and craftsmen, those living from money-wages alone, did suffer a reduction in real incomes owing to rampant inflation. Landowners were also pushed to substitute monetary rents for labour services in an effort to keep tenants.

Environmental
A study performed by Thomas Van Hoof of the Utrecht University suggests that the innumerable deaths brought on by the pandemic cooled the climate by freeing up land and triggering reforestation. This may have led to the Little Ice Age.

Persecutions
Renewed religious fervour and fanaticism bloomed in the wake of the Black Death. Some Europeans targeted "various groups such as Jews, friars, foreigners, beggars, pilgrims", lepers and Romani, blaming them for the crisis. Lepers, and others with skin diseases such as acne or psoriasis, were killed throughout Europe.
Because 14th-century healers and governments were at a loss to explain or stop the disease, Europeans turned to astrological forces, earthquakes and the poisoning of wells by Jews as possible reasons for outbreaks. Many believed the epidemic was a punishment by God for their sins, and could be relieved by winning God's forgiveness.There were many attacks against Jewish communities. In the Strasbourg massacre of February 1349, about 2,000 Jews were murdered. In August 1349, the Jewish communities in Mainz and Cologne were annihilated. By 1351, 60 major and 150 smaller Jewish communities had been destroyed. During this period many Jews relocated to Poland, where they received a warm welcome from King Casimir the Great.

Social
One theory that has been advanced is that the devastation in Florence caused by the Black Death, which hit Europe between 1348 and 1350, resulted in a shift in the world view of people in 14th-century Italy and led to the Renaissance. Italy was particularly badly hit by the pandemic, and it has been speculated that the resulting familiarity with death caused thinkers to dwell more on their lives on Earth, rather than on spirituality and the afterlife. It has also been argued that the Black Death prompted a new wave of piety, manifested in the sponsorship of religious works of art.This does not fully explain why the Renaissance occurred in Italy in the 14th century. The Black Death was a pandemic that affected all of Europe in the ways described, not only Italy. The Renaissance's emergence in Italy was most likely the result of the complex interaction of the above factors, in combination with an influx of Greek scholars following the fall of the Byzantine Empire. As a result of the drastic reduction in the populace the value of the working class increased, and commoners came to enjoy more freedom. To answer the increased need for labour, workers travelled in search of the most favorable position economically.Prior to the emergence of the Black Death, the workings of Europe were run by the Catholic Church and the continent was considered a feudalistic society, composed of fiefs and city-states. The pandemic completely restructured both religion and political forces; survivors began to turn to other forms of spirituality and the power dynamics of the fiefs and city-states crumbled.Cairo's population, partly owing to the numerous plague epidemics, was in the early 18th century half of what it was in 1347. The populations of some Italian cities, notably Florence, did not regain their pre-14th century size until the 19th century. The demographic decline due to the pandemic had economic consequences: the prices of food dropped and land values declined by 30–40% in most parts of Europe between 1350 and 1400. Landholders faced a great loss, but for ordinary men and women it was a windfall. The survivors of the pandemic found not only that the prices of food were lower but also that lands were more abundant, and many of them inherited property from their dead relatives, and this probably destabilised feudalism.The word "quarantine" has its roots in this period, though the concept of isolating people to prevent the spread of disease is older. In the city-state of Ragusa (modern Dubrovnik, Croatia), a thirty-day isolation period was implemented in 1377 for new arrivals to the city from plague-affected areas. The isolation period was later extended to forty days, and given the name "quarantino" from the Italian word for "forty".

Recurrences
Second plague pandemic
The plague repeatedly returned to haunt Europe and the Mediterranean throughout the 14th to 17th centuries. According to Jean-Noël Biraben, the plague was present somewhere in Europe in every year between 1346 and 1671. (Note that some researchers have cautions about the uncritical use of Biraben's data.) The second pandemic was particularly widespread in the following years: 1360–63; 1374; 1400; 1438–39; 1456–57; 1464–66; 1481–85; 1500–03; 1518–31; 1544–48; 1563–66; 1573–88; 1596–99; 1602–11; 1623–40; 1644–54; and 1664–67. Subsequent outbreaks, though severe, marked the retreat from most of Europe (18th century) and northern Africa (19th century). The historian George Sussman argued that the plague had not occurred in East Africa until the 1900s. However, other sources suggest that the Second pandemic did indeed reach Sub-Saharan Africa.According to historian Geoffrey Parker, "France alone lost almost a million people to the plague in the epidemic of 1628–31." In the first half of the 17th century, a plague killed some 1.7 million people in Italy. More than 1.25 million deaths resulted from the extreme incidence of plague in 17th-century Spain.The Black Death ravaged much of the Islamic world. Plague could be found in the Islamic world almost every year between 1500 and 1850. Sometimes the outbreaks affected small areas, while other outbreaks affected multiple regions. Plague repeatedly struck the cities of North Africa. Algiers lost 30,000–50,000 inhabitants to it in 1620–21, and again in 1654–57, 1665, 1691 and 1740–42. Cairo suffered more than fifty plague epidemics within 150 years from the plague's first appearance, with the final outbreak of the second pandemic there in the 1840s. Plague remained a major event in Ottoman society until the second quarter of the 19th century. Between 1701 and 1750, thirty-seven larger and smaller epidemics were recorded in Constantinople, and an additional thirty-one between 1751 and 1800. Baghdad has suffered severely from visitations of the plague, and sometimes two-thirds of its population had died.

Third plague pandemic
The third plague pandemic (1855–1859) started in China in the mid-19th century, spreading to all inhabited continents and killing 10 million people in India alone. The investigation of the pathogen that caused the 19th-century plague was begun by teams of scientists who visited Hong Kong in 1894, among whom was the French-Swiss bacteriologist Alexandre Yersin, after whom the pathogen was named.Twelve plague outbreaks in Australia between 1900 and 1925 resulted in well over 1,000 deaths, chiefly in Sydney. This led to the establishment of a Public Health Department there which undertook some leading-edge research on plague transmission from rat fleas to humans via the bacillus Yersinia pestis.The first North American plague epidemic was the San Francisco plague of 1900–1904, followed by another outbreak in 1907–1908.

Modern-day
Modern treatment methods include insecticides, the use of antibiotics, and a plague vaccine. It is feared that the plague bacterium could develop drug resistance and again become a major health threat. One case of a drug-resistant form of the bacterium was found in Madagascar in 1995. A further outbreak in Madagascar was reported in November 2014. In October 2017, the deadliest outbreak of the plague in modern times hit Madagascar, killing 170 people and infecting thousands.An estimate of the case fatality rate for the modern bubonic plague, following the introduction of antibiotics, is 11%, although it may be higher in underdeveloped regions.

See also
Black Death in England
Black Death in medieval culture
Crisis of the Late Middle Ages
Flagellant
Globalization and disease
List of epidemics
Second plague pandemic
Timeline of plague
Passage 2:
Patricia Millardet
Patricia Millardet (24 March 1957 − 13 April 2020) was a French movie and television actress, who played judge Silvia Conti in the Italian mafia series La piovra.She died of a heart attack in 2020 at the age of 63.

Partial filmography
Passage 3:
La Rosiere de Pessac
La Rosière de Pessac (The Virgin of Pessac) is the title of two hour-long films directed by Jean Eustache (in 1968 and 1979 respectively).  The films cover an annual ceremony, held in Eustache's place of birth, in which the mayor and his associates nominate a girl as the town's most virtuous.  Thus, the girls chosen in those two years are eponymous subjects of these documentaries.

External links
La Rosière de Pessac at IMDb
La Rosière de Pessac at IMDb
Passage 4:
Orlando furioso (Vivaldi, 1714)
Orlando furioso RV 819 (Italian pronunciation: [orˈlando fuˈrjoːzo, -so], Teatro San Angelo, Venice 1714) is a three-act opera surviving in manuscript in Antonio Vivaldi's personal library, only partly related to his better known Orlando furioso (RV 728) of 1727. It is a recomposition of an Orlando furioso written by Giovanni Alberto Ristori which had been very successfully staged by Vivaldi and his father's impresa in 1713, and whose music survives in a few fragments retained in the score of RV 819. Therefore, Vivaldi's first cataloguer Peter Ryom did not assign the opera a RV number, but catalogued it as RV Anh. 84. The libretto was by Grazio Braccioli.

Authorship
Federico Maria Sardelli, according to the studies of Reinhard Strohm, argues that Orlando RV 819 was entirely recomposed by Vivaldi, starting from the original Ristori's opera that Vivaldi himself had already changed during the numerous representations of the season 1713. He assigned to it the catalogue number RV 819. One suggestion is that Vivaldi avoided putting his own name on the opera having himself only recently taken direction of the Teatro San Angelo. Against this others consider that the bulk of the opera is a copy of Ristori's lost work.

Opera
Unlike the Orlando furioso (RV 728) of 1727, in which the role of Orlando is sung by a contralto, the 1714 opera assigns the title role to a bass. The third act is missing and the rest of the score (evidently used in performances by the composer) is incomplete. Two arias are lost, seven arias are incomplete (only the bass part is extant) and three arias are identical with extant arias in RV 727 and RV 729.

Recording
The French label Naïve, which had already recorded the more famous Orlando furioso and Orlando finto pazzo for its Vivaldi Edition, released a recording of the July 20, 2012 première at the Festival de Beaune, with Sardelli conducting Modo Antiquo and singers including Riccardo Novaro as Orlando, Gaëlle Arquez as Angelica, Romina Basso as Alcina and Teodora Gheorghiu as Bradamante. Given the heavily defective nature of the surviving manuscript, Sardelli had to reconstruct or compose ex novo the seven incomplete arias, in a Vivaldian style.

See also
List of operas by Antonio Vivaldi
Passage 5:
Denmark Place fire
The Denmark Place fire occurred on 16 August 1980 at 18 Denmark Place in Central London. The fire, caused by arson, killed 37 people of eight nationalities, most of whom were Spanish or Latin American, who were patrons of two unlicensed bars in the building. At the time, The Sunday Times suggested that it could be "the worst mass murder in British history".

Background
There were two unlicensed bars on the top two floors of 18 Denmark Place: The Spanish Rooms, a late night bar frequented by locals, including Irish and Jamaican immigrants; and Rodo's, also known as El Dandy, a salsa club popular with South American immigrants. Access to both of these bars was obtained by shouting up from the street below in order to obtain a key. The only way into both of these clubs was through a locked front door and up some stairs leading to a landing. 
Access to the club on the lower floor was via this landing and access to the club on the upper floor was via a fire escape enclosed with plywood. Both bars, being unlicensed, were obscured from the outside world by boarded up windows and the door on Denmark Street that led to the fire escape was bolted shut. The Metropolitan Police were aware of the clubs and were planning to shut them both down on Monday 18 August. A farewell party was being thrown over the weekend.

The fire
On the night of 16 August 1980, John Thompson, a Scottish-born petty criminal aged 42, entered The Spanish Rooms and drank there. He believed that the barman had overcharged him for the drink. After fighting with the barman he was ejected from the building and the door was locked behind him. Thompson found a 2-gallon container outside the club, hailed a taxi and then travelled to a 24-hour petrol station in Camden where he filled the container with petrol. He then returned to 18 Denmark Place, poured the petrol through the letterbox of the front door and put a lit piece of paper through.Fire quickly took hold in the premises owing to the largely timber construction of the building. Both bars were badly damaged. There were estimated to be 150 people within the building at the time. People could not escape easily due to the boarded up windows, the locked fire escape and general lack of fire safety precautions owing to the bars' unlicensed status.The fire burned quickly through the wooden staircase, destroying the main entrance and exit to the bars. Some patrons tried to escape via the back door but found that this was locked. Others smashed windows and jumped out onto the street below. On Denmark Street there was a music shop that backed onto the clubs and some patrons were found here trapped behind the security shutters. One firefighter managed to rescue six people from this area.
When firefighters were called to the fire at around 03:30 they could see smoke seeping from the shuttered windows. When an attempt was made to force the locked front door open they were showered with sparks and embers and were forced to retreat. Once firefighters were able to access the front door it took four minutes to break it down – behind it they found that the staircase was completely on fire.
The speed of the fire was so rapid that many of the bar patrons died where they were sitting or standing. An officer from the London Fire Brigade described the scene:

People seem to have died on the spot without even having time to move an inch. Some were slumped at tables. Seven were at the bar and appear to have fallen as they stood, with drinks still in their hands.

Aftermath
In May 1981, Thompson was convicted on a specimen charge of murdering one of the victims, Archibald Campbell (aged 63) and sentenced to life imprisonment. He died of lung cancer on 16 August 2008, the 28th anniversary of the fire.There was comparatively little publicity about the fire, and no formal enquiry into it. The families of some of those who died were not aware of the circumstances. In 2022, after redevelopment of the site, a plaque was placed on a wall in memory.

See also
Blue Bird Café fire, 1972 fire in Montreal started in retaliations by patrons refused entry who then lit petrol in front of main entrance and only exit; also killed 37.
Happy Land fire, 1990 fire in New York City at illegally operated nightclub started the same way by aggrieved ejected patron; resulting 87 fatalities is the worst mass murder in city history caused by a single person.
Clerkenwell cinema fire, 1994 fire in London at an illegally operated adult cinema, intentionally started by an aggrieved patron.
Ghost Ship warehouse fire, 2016 fire at illegally operated nightclub in California that killed 37
Passage 6:
List of bones of the human skeleton
The human skeleton of an adult consists of around 206 bones, depending on the counting of sternum (which may alternatively be included as the manubrium, body of sternum, and the xiphoid process). It is composed of 270 bones at the time of birth, but later decreases to 206: 80 bones in the axial skeleton and 126 bones in the appendicular skeleton. Many small accessory bones, such as sesamoid bones, are not included in this count.

Introduction
As a person ages, some bones fuse, a process which typically lasts until sometime within the third decade of life. Therefore, the number of bones in an individual may be evaluated differently throughout a lifetime. In addition, the bones of the skull and face are counted as separate bones, despite being fused naturally. Some reliable sesamoid bones such as the pisiform are counted, while others, such as the hallux sesamoids, are not.
Individuals may have more or fewer bones than the average (even accounting for developmental stage) owing to anatomical variations. The most common variations include sutural (wormian) bones, which are located along the sutural lines on the back of the skull, and sesamoid bones which develop within some tendons, mainly in the hands and feet. Some individuals may also have additional (i.e., supernumerary) cervical ribs or lumbar vertebrae. Amputations or other injuries may result in the loss of bones. Complete bone fractures may split one bone into multiple pieces. Other genetic conditions may result in abnormally higher (e.g. polydactyly or conjoined twins) or lower (e.g. oligodactyly) counts of bones.

Bones
The axial skeleton, comprising the spine, chest and head, contains 80 bones. The appendicular skeleton, comprising the arms and legs, including the shoulder and pelvic girdles, contains 126 bones, bringing the total for the entire skeleton to 206 bones. Infants are born with about 270 bones with most of it being cartilage, but will later fuse together and decrease over time to 206 bones.

Spine (vertebral column)
A fully grown adult features 26 bones in the spine, whereas a child can have 34.

Cervical vertebrae (7 bones)
Thoracic vertebrae (12 bones)
Lumbar vertebrae (5 bones)
Sacrum (5 bones at birth, fused into one after adolescence)
Coccygeal vertebrae/Cordal (set of 4 bones at birth; some or all fuse together, but there seems to be a disagreement between researchers as to what the most common number should be. Some say the most common is 1, others say 2 or 3, with 4 being the least likely. It is counted as 1 in this article.)

Chest (thorax)
There are 25 bones in the chest. The chest contains cartilage for the lungs to fill with air. 

Sternum (1 or 3 bones. It is counted as 1 in this article.)
Ribs (24, in 12 pairs)
Cervical ribs are extra ribs that occur in some people.

Head
There are 23 bones in the skull. Including the bones of the middle ear and the hyoid bone, the head contains 29 bones.

Cranial bones (8)
Occipital bone
Parietal bones (2)
Frontal bone
Temporal bones (2)
Sphenoid bone (sometimes counted as facial)
Ethmoid bone (sometimes counted as facial)
Facial bones (15)
Nasal bones (2)
Maxillae (upper jaw) (2)
Lacrimal bone (2)
Zygomatic bone (cheek bones) (2)
Palatine bone (2)
Inferior nasal concha (2)
Vomer (1)
Hyoid bone (1)
Mandible (1)
Middle ears (6 bones in total, 3 on each side)
Malleus (2)
Incus (2)
Stapes (2)

Upper limb (arm and forearm) and hand
There are a total of 64 bones in the arms, 32 in each arm

Upper arm bones (6 bones in total; 3 on each side)
Humerus (2)
Pectoral girdle (shoulder)
Scapula (2)
Clavicle (2)
Lower arm bones (4 bones in total, 2 on each side) left bone
Ulna (2) (Lined up with pinky)
Radius (2) (Lined up with thumb)
Hand (54 bones in total; 27 in each hand)
Carpals
Scaphoid bone (2)
Lunate bone (2)
Triquetral bone (2)
Pisiform bone (2)
Trapezium (2)
Trapezoid bone (2)
Capitate bone (2)
Hamate bone (2)
Metacarpals (10 bones in total; 5 on each side)
Phalanges of the hand (28 bones in total, 14 on each hand)
Proximal phalanges (10 bones in total; 5 on each side)
Intermediate phalanges (8 bones in total; 4 on each side)
Distal phalanges (10 bones in total; 5 on each side)

Pelvis (pelvic girdle)
The pelvis (or hip bone) is made up of three regions that have fused to form two coxal bones. They are the ilium, ischium, and pubis.

The sacrum and coccyx attach to the two hip bones to form the pelvis, but are more important to the spinal column, where they are counted.The pelvis is one of two bones used to determine the sex of a skeleton, which is determined by examining the size of the greater sciatic notch (also known as the pelvic opening).

Lower limb (thigh and leg) and foot
There are a total of 60 bones in the legs.

Femur (2)
Patella or kneecap (2)
Tibia (2)
Fibula (2)
Foot (52 bones in total, 26 per foot)
Tarsus/Tarsals
Calcaneus or heel bone (2)
Talus (2)
Navicular bone (2)
Medial cuneiform bone (2)
Intermediate cuneiform bone (2)
Lateral cuneiform bone (2)
Cuboid bone (2)
Metatarsals (10)
Phalanges of the foot (28 bones in total, 14 per foot)
Proximal phalanges (10)
Intermediate phalanges (8)
Distal phalanges (10)

See also
List of skeletal muscles of the human body
List of nerves of the human body
Circulatory system
Blood vessel
Passage 7:
2010 Elazığ earthquake
The 2010 Elazığ earthquake was a 6.1 Mw earthquake that occurred on 8 March 2010 at 02:32 UTC (04:32 local time). The epicentre was Başyurt in Elazığ Province, in eastern Turkey. Initial reports in global media said as many as 57 people had died. By 10 March, reports in the Turkish media placed the death toll at 41 and later, the death toll rose to 42. Another 74 were injured, many after falling and jumping from buildings. A stampede through the streets led to further injuries.The earthquake came one week to the day after the Turkish Chamber of Civil Engineers sent a report to parliament detailing inadequate building projects and the possibility that Istanbul would be destroyed by an earthquake, which could kill tens of thousands of people, at some point in the next three decades.

Earthquake
The quake occurred on the East Anatolian Fault, a major transform fault which represents  the boundary between the Anatolian Plate and the Arabian Plate.

Damage
According to officials, most of the deaths occurred in three villages: Okçular, Yukarı Kanatlı and Kayalı. At least five villages, though, suffered loss of life. Villagers fled buildings, spending the night outside and lighting fires in the streets for warmth.Thirty houses collapsed in Okçular, and the death toll is at least 17. Reports from the scene indicate "the village is totally flattened" and "everything has been knocked down – there is not a stone in place".At least 25 people died in Yukarı Demirci, and emergency services went to Kovancılar.Many people used vehicles and taxis to drive to the hospital. Most were asleep at the time the quake struck, with four sleeping sisters perishing in one house. Farm animals were also killed, and minarets fell down.

Aftershocks
Several aftershocks were felt, the strongest measuring 5.5 (at 09:47 local time), 5.1 (at 12:14) and 5.3 (at 13:12). A total of over 20 aftershocks were counted within a short time following the quake. Villagers were told to stay away from buildings for several days due to the potential of further aftershocks.Onur Tan et al. (2011) analyzed 2130 aftershocks (ML≥0.3) and reported in Geophysical Research Letters.

Response
Turkey: Four government ministers, including Deputy Prime Minister Cemil Çiçek, visited the scene as soon as news of the earthquake was reported. The Red Crescent and Turkey's disaster management centre donated blankets and tents. Prime Minister Recep Tayyip Erdoğan later arrived. Pakistan: Prime Minister Yousaf Raza Gillani sent a condolence message to his Turkish counterpart Recep Tayyip Erdoğan over the loss of lives and property and said that "We have learnt with utter sense of shock and profound sadness the news of the massive earthquake that has hit your beautiful country, today. Our hearts go out to our Turkish brethren over the loss of precious lives and destruction of property. I wish to convey, on behalf of the people and Government of Pakistan and on my own behalf our deepest condolences and commiserations to the people and Government of Turkey in bearing this enormous natural calamity." Israel: Defense Minister Ehud Barak ordered an aid proposal to be put together but later said that Turkey informed Israel that it did not require assistance at this time.

See also
2020 Elazığ earthquake
List of earthquakes in 2010
List of earthquakes in Turkey
Passage 8:
La Cantuta massacre
La Cantuta massacre took place in Peru on 18 July 1992, during the presidency of Alberto Fujimori. Supposed members of Shining Path, including a university professor and nine students from Lima's La Cantuta University, were abducted, tortured, and killed by Grupo Colina, a military death squad. The incident occurred two days after the Shining Path's Tarata bombing, which killed over 40 people in Lima Province.
The massacre was one of the crimes cited in the conviction of Fujimori on 7 April 2009, for human rights abuses.

Context
The Enrique Guzmán y Valle National Education University (Universidad Nacional de Educación Enrique Guzmán y Valle, or "UNE"; better known as "La Cantuta", from the neighbourhood in which it stands) was founded as a teacher-training college in 1822, granted its university charter in 1965, closed down by the military government in 1977, and reopened in 1980.Because of its remote location, far away from the centre of Lima, the fact that most of its students hailed from the impoverished interior of the country, and that most of them intended to enter the highly politicised teaching profession, La Cantuta gained a reputation as hotbed of radical politics, such as communism and anarchism as early as the late 1950s and early 1960s. A series of student-led protest actions on the campus — including the blocking of the railway line linking Lima with the interior of the country — that led to the suspension of its activities in 1977.With the return of democratic rule in 1980, President Belaúnde reopened the university. The radical elements among the students and lecturers were quick to return, and by the mid-1980s the country's two main insurgent groups, Shining Path (Sendero Luminoso) and the Túpac Amaru Revolutionary Movement (MRTA), had a strong presence on campus, being widely regarded as 2 very legitimate organisations. By the early 1990s, due to a strategic withdrawal by MRTA and the fragmentation of the other left-wing groups on campus, legal and illegal alike, Sendero Luminoso had the upper hand. This was in spite of operations such as that of 13 February 1987, when 4000 police officers conducted night-time raids at the dormitories of three state universities (including La Cantuta); 20 April 1989, when a joint force of police and army descended on La Cantuta University and San Marcos National University and arrested over 500 students on charges of subversion; or 22 May 1991, when, in response to a hostage crisis and rumors of an explosive device squirreled away on campus, Fujimori sent the army in to restore law and order at La Cantuta. Graffiti alluding to Sendero Luminoso and its leader, Abimael Guzmán, were painted over with patriotic slogans; students went about their business only after passing checkpoints and under close supervision from the armed forces; and the campus remained under military control for several years.

Abduction of July 1992
In the pre-dawn hours of 18 July 1992, two days after the Tarata bombing, members of the Army Intelligence Service (SIE) and the Army Directorate of Intelligence (DINTE), most of whom were attached to the recently established Grupo Colina death squad, burst into the residences of the Enrique Guzmán y Valle National University.Once inside, the troops forced all the students to leave their rooms and lie belly-down on the floor. Nine students believed to be linked to the Tarata Bombing — Bertila Lozano Torres, Dora Oyague Fierro, Luis Enrique Ortiz Perea, Armando Richard Amaro Cóndor, Robert Édgar Teodoro Espinoza, Heráclides Pablo Meza, Felipe Flores Chipana, Marcelino Rosales Cárdenas, and Juan Gabriel Mariños Figueroa — were separated from the others and taken away. Meanwhile, in the staff residences, a group of soldiers broke into the home of professor Hugo Muñoz Sánchez. After searching his bedroom, they gagged the professor and led him away.

Prosecutions and amnesty
In April 1993, a group of Peruvian military officers anonymously released a document detailing the events at La Cantuta. Their document claimed the death squad had abducted the victims, tortured and murdered them, and then hurriedly buried them; later, they claimed, after questions had been raised in Congress, that the armed forces had exhumed, incinerated, and reburied the bodies in another location. The military whistleblowers named the members of Grupo Colina involved, identified the operations chief as Major Santiago Martín Rivas, and suggested that the group operated on the orders of Vladimiro Montesinos, head of the National Intelligence Service (SIN) and a close advisor to President Fujimori.
On 6 May, Lt. Gen. Humberto Robles Espinoza, the army's third highest-ranking officer, publicly denounced a number of human rights violations committed by the SIN and the armed forces, including the La Cantuta killings. He was later dismissed from duty and subjected to death threats, and finally fled the country for political asylum in Argentina.In June 1993, Justo Arizapana Vicente, a recycler, and his friend Guillermo Cataroca, leaked a marked map to congress man Roger Cáceres Velásquez and Radio Comas journalist Juan Jara Berrospi. Cáceres then shared the map with Ricardo Uceda at the news magazine Sí, who published it in July of that year. Mariella Barreto, an agent of the Peruvian Army Intelligence Service, is also sometimes credited with leaking this map to a Peruvian magazine. An investigation of the site indicated on the map by the public prosecutor revealed four clandestine graves. Forensic tests conducted on the remains, and on another set of bones found at another site, revealed that they belonged to Muñoz Sánchez and the students Luis Enrique Ortiz Perea, Armando Amaro Condor, and Juan Gabriel Mariños Figueroa, and that at least some of them had been tortured prior to receiving an execution-style coup-de-grâce to the base of the neck. Barreto was murdered some years later: her decapitated and dismembered corpse, showing signs of ante-mortem torture, was found in March 1997. A few weeks after Mariella Barreto's death, her colleague Leonor La Rosa, was on TV in a hospital bed, declaring she had been tortured and that Barreto had been killed in retaliation for leaking information to the press about the Groupo Colina's plan to intimidate journalists and politicians from the opposition.The military authorities had begun an investigation into the killings in May 1993. In addition, in December 1993, a civilian prosecutor filed criminal charges against several named members of the military. A conflict of jurisdiction thus arose between the military and civilian courts. The controversy was placed before the Supreme Court which, on 3 February 1994, ruled that it was unable to reach agreement on which venue should apply. Consequently, on the night of 7 February, Congress enacted a new law whereby the Supreme Court could decide such matters with a simple majority, instead of a unanimous vote. By a three-to-two vote of the Supreme Court's criminal division, the case was placed under military jurisdiction.On 21 February 1994, the Supreme Council of Military Justice (CSJM) sentenced ten of the perpetrators to prison sentences of between one and 20 years.Following Fujimori's landslide re-election in April 1995, in another all-night session on 14 June 1995, Congress enacted law No. 26479, the "Amnesty Law", ordering the release of all police officers, soldiers, and civil servants convicted of or charged with civilian or military crimes during Peru's War on Terrorism. On 15 July, the Supreme Council of Military Justice ordered the release of all the individuals convicted for the La Cantuta killings.

Repeal of the Amnesty Law
The Amnesty Law was repealed after the Fujimori government in 2000 and, on 21 March 2001, Attorney General Nelly Calderón presented charges against Fujimori, accusing him of being one of the "co-authors" of this massacre and of the 1991 Barrios Altos massacre. She presented evidence that Fujimori, acting in concert with SIN supremo Vladimiro Montesinos, exercised control over Grupo Colina. The charges alleged that the group could not have committed crimes of this magnitude without Fujimori's express orders or consent, and that the formation and function of the Colina group was part of an overall counter-insurgency policy that involved systematic violations of human rights.

Prosecutions and apology
In November 2005, Fujimori was detained in Chile. Peruvian authorities filed for his extradition to face charges arising from various incidents during his presidency, including the La Cantuta massacre, and he was returned to Peru on 22 September 2007.
On 8 April 2008, a court found a number of people, including Julio Salazar, guilty of kidnapping, homicide, and forced disappearance.In October 2007, pursuant to a 2006 ruling from the Inter-American Court of Human Rights, the government extended a formal apology for the massacre and undertook to make amends to the victims' next-of-kin, including compensation in the amount of US$1.8 million.

Fujimori's trial
During the trial of Alberto Fujimori, it was asserted by former Colina member José William Tena Jacinto that at least two of the victims were positively identified as Shining Path members.Lieutenant Aquilino Portella and the Dean of the Social Science Department of the University, Claudio Cajahuaringa, have also claimed that Professor Hugo Muñoz Sánchez and student Bertila Lozano Torres were involved with Shining Path. In the case of Lozano, it was claimed that documents allegedly in her possession revealed that she was indeed an actual member of the insurgent organization.In 2009 it was determined by a judicial ruling that not a single one of the victims in La Cantuta massacre was linked to any terrorist organization, it was in the same ruling that condemned Fujimori to a 25 years imprisonment for crimes against humanity.

See also
List of massacres in Peru

Notes
External links
"The La Canuta Case". APRODEH.
La Cantuta Case – Inter-American Commission on Human Rights
La Cantuta Case vs. Peru – Inter-American Court of Human Rights
La Cantuta – Truth and Reconciliation Commission, final report (PDF; Spanish)
La Cantuta – overview (MIT Western Hemisphere Project)
La Cantuta – summary of events (Spanish)
Questions and answers about Fujimori's criminal prosecution – Human Rights Watch
Passage 9:
La Silvia
La Silvia (RV 734) is an dramma pastorale per musica in three acts by Antonio Vivaldi to an Italian libretto by Enrico Bissari. It was first performed on 28 August 1721 at the Teatro Regio Ducale in Milan on the occasion of the birthday celebrations of the Austrian Empress Elisabeth Christine, wife of Emperor Charles VI of Austria.

Background
In 1718 Vivaldi had been nominated maestro di cappella di camera, at the court of Philipp von Hessen-Darmstadt in Mantua for whom he composed Armida al campo d'Egitto, Teuzzone, Scanderbeg (all 1718) and then Tito Manlio (1719) and La Candace (1720). On his return to Venice, following performance of La verità in cimento at the Teatro Sant'Angelo, Vivaldi, thinly disguised as "Aldiviva", became, along with Giovanni Porta, Anna Maria Strada and others, one of the principal targets of the gentleman-composer Benedetto Marcello's satirical pamphlet Il teatro alla moda (written 1718-1719, published 1720).Bissari's text had originally been written in 1710 as a play for Princess Teresa Kunegunda Sobieska, second wife of the Bavarian elector Maximillian II Emmanuel. The opera was performed again in Milan in 1723 and 1724. 8 of the arias are preserved in the Biblioteca Nazionale di Torino.

Roles
Recordings
2001 (reconstruction of nine surviving arias) Roberta Invernizzi, Gloria Banditelli, John Elwes, Philippe Cantor.  Ensemble Baroque de Nice, dir. Gilbert Bezzina. Ligia. 1CD.
Passage 10:
Giovanni Cifolelli
Giovanni Cifolelli was an Italian mandolin virtuoso and dramatic composer whose date and place of birth are unknown. In 1764 he made his appearance in Paris as a mandolin virtuoso and was highly esteemed, both as a performer and teacher. He published his Method for the mandolin while residing in Paris, which met with great success throughout France, being the most popular of its period.
His chief works were the operas L'Italienne and Pierre et Lucette, the former being an opera bouffe in one act (with the storyline or libretto by Nicolas-Étienne Framery). These works were commissioned by the Comedie Italienne, Paris, and were produced at this theatre successfully, in 1770 and 1774. Several of the songs and duets in Pierre and Lucette were exceedingly popular in France, and they were republished in Paris in 1775 and 1780.

Works
L'Italienne  : comédie en 1 acte, mêlée d'ariettes (Paris, 1770)
Pierre et Lucette, comédie en deux actes et en prose mêlée d'ariettes (Paris, 1774)
Airs détachés de Perin et Lucette, comédie en deux actes, mêlées d'ariettes par M. Davesne (Paris, 1775)
Ariette nouvelle avec accompagnement de deux violons et basse
Non, laisse moi, laisse moi, Lucas. Duo (1775)

Answer the question based on the given passages. Only give me the answer and do not output any other words.

Question: How many times did plague occur in the birthplace of La Silvia's composer?



Answer: 22