prompt_front: Now, answer the following question based on the text below, only give me the answer and do not output any other words.

Question: What kind of ultracold neutral plasmas does this study focus on?

Read the following text and answer briefly.

Context 1: \section{Introduction}

Ultracold neutral plasmas studied in the laboratory offer access to a regime of plasma physics that scales to describe thermodynamic aspects of important high-energy-density systems, including strongly coupled astrophysical plasmas \cite{VanHorn,Burrows}, as well as terrestrial sources of neutrons \cite{Hinton,Ichimaru_fusion,Atzeni,Boozer} and x-ray radiation \cite{Rousse,Esarey}   Yet, under certain conditions, low-temperature laboratory plasmas evolve with dynamics that are governed by the quantum mechanical properties of their constituent particles, and in some cases by coherence with an external electromagnetic field    

The relevance of ultracold plasmas to such a broad scope of problems in classical and quantum many-body physics has given rise to a great deal of experimental and theoretical research on these systems since their discovery in the late 90s   A series of reviews affords a good overview of progress in the last twenty years \cite{Gallagher,Killian_Science,PhysRept,Lyon}   Here, we focus on the subset of ultracold neutral plasmas that form via kinetic rate processes from state-selected Rydberg gases, and emphasize in particular the distinctive dynamics found in the evolution of molecular ultracold plasmas   

While molecular beam investigations of threshold photoionization spectroscopy had uncovered relevant effects a few years earlier \cite{Scherzer,Alt}, the field of ultracold plasma physics began in earnest with the 1999 experiment of Rolston and coworkers on metastable xenon atoms cooled in a magneto optical trap (MOT) \cite{Killian}   

This work and many subsequent efforts tuned the photoionization energy as a means to form a plasma of very low electron temperature built on a strongly coupled cloud of ultracold ions   Experiment and theory soon established that fast processes associated with disorder-induced heating and longer-time electron-ion collisional rate processes act to elevate the ion temperatures to around one degree Kelvin, and constrain the effective initial electron temperature to a range above 30 K \cite{Kuzmin,Hanson,Laha}   

This apparent limit on the thermal energy of the electrons can be more universally expressed for an expanding plasma by saying that the electron correlation parameter, $\Gamma_e$, does not exceed 0 25, where, 
\begin{equation}
\Gamma_e = \frac{e^2}{4\pi \epsilon_0 a_{ws}}\frac{1}{k_B T_e}
\label{eqn:gamma_e}
\end{equation}
defines the ratio of the average unscreened electron-electron potential energy to the electron kinetic energy   $a_{ws}$ is the Wigner-Seitz radius, related to the electron density by, $\rho_e = 1/(\frac{4}{3} \pi a_{ws}^3)$   These plasmas of weakly coupled electrons and strongly coupled ions have provided an important testing ground for ion transport theory and the study of electron-ion collision physics \cite{Strickler} 

Soon after the initial reports of ultracold plasmas formed by direct photoionization, a parallel effort began with emphasis on the plasma that forms spontaneously by Penning ionization and electron-impact avalanche in a dense ultracold Rydberg gas \cite{Mourachko}   This process affords less apparent control of the initial electron temperature   But, pulsed field-ionization measurements soon established that the photoionized plasma and that formed by the avalanche of a Rydberg gas both evolve to quasi-equilibria of electrons, ions and high-Rydberg neutrals \cite{Rolston_expand,Gallagher}   

Early efforts to understand plasmas formed by Rydberg gas avalanche paid particular attention to the process of initiation   Evolution to plasma in effusive atomic beams was long known for high-Rydberg gases of caesium and well explained by coupled rate equations \cite{Vitrant}   But, low densities and ultracold velocity distributions were thought to exclude Rydberg-Rydberg collisional mechanisms in a MOT   

In work on ultracold Rydberg gases of Rb and Cs, Gallagher, Pillet and coworkers describe the initial growth of electron signal by a model that includes ionization by blackbody radiation and collisions with a background of uncooled Rydberg atoms \cite{Mourachko,Gallagher,Li,Comparat,Tanner}  This picture was subsequently refined to include many-body excitation and autoionization, as well as attractive dipole-dipole interactions \cite{Viteau,Pillet}, later confirmed by experiments at Rice \cite{Mcquillen}   

The Orsay group also studied the effect of adding Rydberg atoms to an established ultracold plasma   They found that electron collisions in this environment completely ionize added atoms, even when selected to have deep binding energies \cite{Vanhaecke}   They concluded from estimates of electron trapping efficiency that the addition of Rydberg atoms does not significantly alter the electron temperature of the plasma   

Tuning pair distributions by varying the wavelength of the excitation laser, Weidem\"uller and coworkers confirmed the mechanical effects of van der Waals interactions on the rates of Penning ionization in ultracold $^{87}$Rb Rydberg gases \cite{Amthor_mech}   They recognized blackbody radiation as a possible means of final-state redistribution, and extended this mechanical picture to include long-range repulsive interactions \cite{Amthor_model}   This group later studied the effects of spatial correlations in the spontaneous avalanche of Rydberg gases in a regime of strong blockade, suggesting a persistence of initial spatial correlations \cite{RobertdeSaintVincent}   

Robicheaux and coworkers have recently investigated the question of prompt many-body ionization from the point of view of Monte Carlo classical trajectory calculations \cite{Goforth}   For atoms on a regular or random grid driven classically by an electromagnetic field, they find that many-body excitation enhances prompt ionization by about twenty percent for densities greater than $5 6 \times 10^{-3}/(n_0^2 a_0)^3$, where $n_0$ is the principal quantum number of the Rydberg gas and $a_0$ is the Bohr radius   They observed that density fluctuations (sampled from the distribution of nearest neighbour distances) have a greater effect, and point to the possible additional influence of secondary electron-Rydberg collisions and the Penning production of fast atoms not considered by the model, but already observed by Raithel and coworkers \cite{Knuffman}   

The Raithel group also found direct evidence for electron collisional $\ell$-mixing in a Rb MOT \cite{Dutta}, and used selective field ionization to monitor evolution to plasma on a microsecond timescale in ultracold $^{85}$Rb $65d$ Rydberg gases with densities as low as $10^8$ cm$^{-3}$ \cite{WalzFlannigan}   Research by our group at UBC has observed very much the same dynamics in the relaxation of Xe Rydberg gases of similar density prepared in a molecular beam \cite{Hung2014}   In both cases, the time evolution to avalanche is well-described by coupled rate equations (see below), assuming an initializing density of Penning electrons determined by Robicheaux's criterion \cite{Robicheaux05}, applied to an Erlang distribution of Rydberg-Rydberg nearest neighbours   

Theoretical investigations of ultracold plasma physics have focused for the most part on the long- and short-time dynamics of plasmas formed by direct photoionization \cite{PhysRept,Lyon}   In addition to studies mentioned above, key insights on the evolution dynamics of Rydberg gases have been provided by studies of Pohl and coworkers exploring the effects of ion correlations and recombination-reionization on the hydrodynamics of plasma expansion \cite{Pohl:2003,PPR}   Further research has drawn upon molecular dynamics (MD) simulations to reformulate rate coefficients for the transitions driven by electron impact between highly excited Rydberg states \cite{PVS}, and describe an effect of strong coupling as it suppresses three-body recombination \cite{Bannasch:2011}   MD simulations confirm the accuracy of coupled rate equation descriptions for systems with $\Gamma$ as large as 0 3   Newer calculations suggest a strong connection between the order created by dipole blockade in Rydberg gases and the most favourable correlated distribution of ions in a corresponding strongly coupled ultracold plasma \cite{Bannasch:2013}   

Tate and coworkers have studied ultracold plasma avalanche and expansion theoretically as well as experimentally   Modelling observed expansion rates, they recently found that $^{85}$Rb atoms in a MOT form plasmas with effective initial electron temperatures determined by initial Rydberg density and the selected initial binding energy, to the extent that these parameters determine the fraction of the excited atoms that ionize by electron impact in the avalanche to plasma \cite{Forest}   This group also returned to the question of added Rydberg atoms, and managed to identify a crossover in $n_0$, depending on the initial electron temperature, that determines whether added Rydberg atoms of a particular initial binding energy act to heat or cool the electron temperature \cite{Crockett}    

Our group has focused on the plasma that evolves from a Rydberg gas under the low-temperature conditions of a skimmed, seeded supersonic molecular beam   In work on nitric oxide starting in 2008 \cite{Morrison2008,Plasma_expan,Morrison_shock,PCCP}, we established an initial kinetics of electron impact avalanche ionization that conforms with coupled rate equation models \cite{Saquet2011,Saquet2012,Scaling,haenelCP} and agrees at early times with the properties of ultracold plasmas that evolve from ultracold atoms in a MOT   We have also observed unique properties of the NO ultracold plasma owing to the fact that its Rydberg states dissociate \cite{Haenel2017}, and identified relaxation pathways that may give rise to quantum effects \cite{SousMBL,SousNJP}   The remainder of this review focuses on the nitric oxide ultracold plasma and the unique characteristics conferred by its evolution from a Rydberg gas in a laser-crossed molecular beam   


\section{Avalanche to strong coupling in a molecular Rydberg gas}

\subsection{The molecular beam ultracold plasma compared with a MOT}

When formed with sufficient density, a Rydberg gas of principal quantum number $n_0>30$ undergoes a spontaneous avalanche to form an ultracold plasma \cite{Li,Morrison2008,RobertdeSaintVincent}   Collisional rate processes combine with ambipolar hydrodynamics to govern the properties of the evolving plasma   For a molecular Rydberg gas, neutral fragmentation, occurs in concert with electron-impact ionization, three-body recombination and electron-Rydberg inelastic scattering   Neutral dissociation combined with radial expansion in a shaped distribution of charged particles, can give rise to striking effects of self-assembly and spatial correlation \cite{Schulz-Weiling2016,Haenel2017}    

The formation of a molecular ultracold plasma requires the conditions of local temperature and density afforded by a high mach-number skimmed supersonic molecular beam   Such a beam propagates at high velocity in the laboratory, with exceedingly well-defined hydrodynamic properties, including a propagation-distance-dependent density and sub-Kelvin temperature in the moving frame \cite{MSW_tutorial}   The low-temperature gas in a supersonic molecular beam differs in three important ways from the atomic gas laser-cooled in a magneto-optical trap (MOT) 

The milli-Kelvin temperature of the gas of ground-state NO molecules entrained in a beam substantially exceeds the sub-100 micro-Kelvin temperature of laser-cooled atoms in a MOT   However, the evolution to plasma tends to erase this distinction, and the two further characteristics that distinguish a beam offer important advantages for ultracold plasma physics:  Charged-particle densities in a molecular beam can exceed those attainable in a MOT by orders of magnitude   A great many different chemical substances can be seeded in a free-jet expansion, and the possibility this affords to form other molecular ultracold plasmas, introduces interesting and potentially important new degrees of freedom governing the dynamics of their evolution 


\subsection{Supersonic molecular beam temperature and particle density}

Seeded in a skimmed supersonic molecular beam, nitric oxide forms different phase-space distributions in the longitudinal (propagation) and transverse coordinate dimensions   As it propagates in $z$, the NO molecules reach a terminal laboratory velocity, $u_{\parallel}$, of about 1400 ${\rm ms^{-1}}$, which varies with the precise seeding ratio   

The distribution of $v_{\parallel}$, narrows to define a local temperature, $T_{\parallel}$, of approximately 0 5 K   The beam forms a Gaussian spatial distribution in the transverse coordinates, $x$ and $y$   In this plane, the local velocity, $v_{\perp}(r)$ is defined for any radial distance almost entirely by the divergence velocity of the beam, $u_{\perp}(r)$   Phase-space sorting cools the temperature in the transverse coordinates, $T_{\perp}$ to a value as low as $\sim 5$ mK \cite{MSW_tutorial}   

The stagnation pressure and seeding ratio determine the local density distribution as a function of $z$   For example, expanding from a stagnation pressure of 500 kPa with a 1:10 seeding ratio, a molecular beam propagates 2 5 cm to a skimmer and then 7 5 cm to a point of laser interaction, where it contains NO at a peak density of $1 6 \times 10^{14}$ cm$^{-3}$   

Here, crossing the molecular beam with a laser beam tuned to the transition sequence, ${\rm X} ~^2 \Pi_{1/2} ~N'' = 1 \xrightarrow{\omega_1} {\rm A} ~^2\Sigma^+ ~N'=0  \xrightarrow{\omega_2} n_0 f(2)$ forms a Gaussian ellipsoidal volume of Rydberg gas in a single selected principal quantum number, $n_0$, orbital angular momentum, $\ell = 3$, NO$^+$ core rotational quantum number, $N^+ = 2$ and total angular momentum neglecting spin, $N=1$   

A typical $\omega_1$ pulse energy of 2 $\mu$J and a Gaussian width of 0 2 mm serves to drive the first step of this sequence in a regime of linear absorption   Overlapping this volume by an $\omega_2$ pulse with sufficient fluence to saturate the second step forms a Rydberg gas ellipsoid with a nominal peak density of $5 \times 10^{12}$ cm$^{-3}$  \cite{Morrison2008,MSW_tutorial}   Fluctuations in the pulse energy and longitudinal mode of $\omega_1$ cause the real density to vary   For certain experiments, we find it convenient to saturate the $\omega_1$ transition, and vary the density of Rydberg gas by delaying $\omega_2$   An $\omega_1$-$\omega_2$ delay, $\Delta t$, reduces the Rydberg gas density by a precise factor, $e^{-\Delta t/\tau}$, where $\tau$ is the 200 ns radiative lifetime of NO ${\rm A} ~^2\Sigma^+ ~N'=0$ \cite{Carter,Hancock} 


\subsection{Penning ionization}

The density distribution of a Rydberg gas defines a local mean nearest neighbour distance, or Wigner-Seitz radius of $ a_{ws} =  \left(3/4 \pi \rho \right)^{1/3} $, where $\rho$ refers to the local Rydberg gas density   For example, a Rydberg gas with a density of $ \rho_0=0 5 \times 10^{12}$ cm$^{-3} $ forms an Erlang distribution \cite{Torquato 1990} of nearest neighbour separations with a mean value of $ 2 a_{ws}=1 6$  $\mu$m   

A semi-classical model \cite{Robicheaux05} suggests that 90 percent of Rydberg molecule pairs separated by a critical distance, $ r_c = 1 8 \cdot 2 n_0^2 a_0 $ or less undergo Penning ionization within 800 Rydberg periods   We can integrate the Erlang distribution from $ r=0 $ to the critical distance $r = r_c$ for a Rydberg gas of given $n_0$, to define the local density of Penning electrons ($ \rho_e$ at $t=0$) produced by this prompt interaction, for any given initial local density, $\rho_0$ by the expression:
\begin{equation}
\rho_e(\rho_0,n_0) = \frac{0 9}{2} \cdot 4 \pi \rho_0 ^2\int_0^{r_{c}} r^2 \mathrm{e}^{-\frac{4\pi}{3}\rho_0 r^3}\mathrm{d}r \quad 
\label{eqn:Erlang}
\end{equation}

Evaluating this definite integral yields an equation in closed form that predicts the Penning electron density for any particular initial Rydberg density and principal quantum number 
\begin{equation}
\rho_e(\rho_0,n_0) =\frac{0 9 \rho_0}{2}(1-\mathrm{e}^{-\frac{4\pi}{3}\rho_0 r_c^3}) \quad 
\label{Eq:PenDens}
\end{equation}
\begin{figure}[h!]
\centering
\includegraphics[scale=0 33]{Penning_Latice pdf}
\caption{Distributions of ion-ion nearest neighbours following Penning ionization and electron-impact avalanche simulated for a predissociating molecular Rydberg gas of initial principal quantum number, $n_0$, from 30 to 80, and density of 10$^{12}$ cm$^{-3}$   Dashed lines mark corresponding values of $a_{ws}$  Calculated by counting ion distances after relaxation to plasma in 10$^6$-particle stochastic simulations  Integrated areas proportional to populations surviving neutral dissociation }
\label{fig:PL}
\end{figure}

Prompt Penning ionization acts on the portion of the initial nearest-neighbour distribution in the Rydberg gas that lies within $r_c$   When a molecule ionizes, its collision partner relaxes to a lower principal quantum number, $n'<n_0/\sqrt{2}$   This close-coupled interaction disrupts the separability of Rydberg orbital configurations in the Penning partner   This causes mixing with core penetrating states that are strongly dissociative   Penning partners are thus very likely to dissociate, leaving a spatially isolated distribution of ions   We refer to the spatial correlation that results as a Penning lattice \cite{Sadeghi:2014}   The extent of this effect varies depending on the local density and the selected initial principal quantum number   Figure \ref{fig:PL} shows the degree to which Rydberg gases with initial principal quantum numbers from 30 to 80 form a Penning lattice for an initial density of $1 \times 10^{12} ~{\rm cm}^{-3}$   

\subsection{Spontaneous electron-impact avalanche}

The electrons produced by prompt Penning ionization start an electron impact avalanche   The kinetics of this process are well described by a set of coupled rate equations that account for state-to-state electron-Rydberg inelastic scattering, electron-impact ionization and three-body ion-electron recombination \cite{PPR,Saquet2011,Saquet2012,Scaling} using detailed rate coefficients,  $k_{ij}$, $k_{i,ion}$ and $k_{i,tbr}$ validated by MD simulations \cite{PVS}   
\begin{eqnarray}
-\frac{d\rho_i}{dt}&=&\sum_{j}{k_{ij}\rho_e\rho_i}-\sum_{j}{k_{ji}\rho_e\rho_j} \nonumber\\
&& +k_{i,ion}\rho_e\rho_i-k_{i,tbr}\rho^3_e 
  \label{level_i}
\end{eqnarray}
\noindent and,
\begin{equation}
\frac{d\rho_e}{dt}=\sum_{i}{k_{i,ion}\rho_e^2}-\sum_{i}{k_{i,tbr}\rho^3_e}
  \label{electron}
\end{equation}

The relaxation of Rydberg molecules balances with collisional ionization to determine an evolving temperature of avalanche electrons to conserve total energy per unit volume  
\begin{equation}
E_{tot}=\frac{3}{2}k_BT_e(t)\rho_e(t)-R\sum_i{\frac{\rho_i(t)}{n_i^2}},
  \label{energy}
\end{equation}
Here, for simplicity, we neglect the longer-time effects of Rydberg predissociation and electron-ion dissociative recombination \cite{Saquet2012} 

Such calculations show that the conversion from Rydberg gas to plasma occurs on a timescale determined largely by the local Penning electron density, or Penning fraction, $P_f = \rho_e/\rho_0$, which depends on the local density of Rydberg molecules and their initial principal quantum number   

Avalanche times predicted by coupled rate equation calculations range widely   For example, in a model developed for experiments on xenon, simulations predict that a Rydberg gas with $n_0 = 42$ at a density of $8 8 \times 10^8 ~{\rm cm}^{-3}$ ($P_f = 6 \times 10^{-5}$) avalanches with a half time of  40 $\mu$s \cite{Hung2014}   At an opposite extreme, rate equations estimate that a Rydberg gas of NO with $n_0=60$ at a density of $1 \times 10^{12} ~{\rm cm}^{-3}$ ($P_f = 0 3$) rises to plasma in about 2 ns \cite{Saquet2012}   

\begin{figure}[h!]
\centering
\includegraphics[width=  49 \textwidth]{SFI_n=49 pdf}
   \caption{Contour plots showing SFI signal as a function the applied field for an $nf(2)$ Rydberg gas with an initial principal quantum number, $n_0=49$   Each frame represents 4,000 SFI traces, sorted by initial Rydberg gas density   Ramp field beginning at 0 and 150 ns (top, left to right), and  300 and 450 ns (bottom) after the $\omega_2$ laser pulse   The two bars of signal most evident at early ramp field delay times represent the field ionization of the $49f(2)$ Rydberg state respectively to NO$^+$ X $^1\Sigma^+$ cation rotational states, $N^+=0$ and 2   The signal waveform extracted near zero applied field represents the growing population of plasma electrons   
   }
\label{fig:SFI}
\end{figure}

Selective field ionization (SFI) probes the spectrum of binding energies in a Rydberg gas   Applied as a function of time after photoexcitation, SFI maps the evolution from a state of selected initial principal quantum number, $n_0$, to plasma \cite{Haenel2017}   Figure \ref{fig:SFI} shows SFI spectra taken at a sequence of delays after the formation of $49f(2)$ Rydberg gases of varying density     

Here, we can see that a $49f(2)$ Rydberg gas with an estimated initial density $\rho_0 = 3 \times 10^{11} ~{\rm cm}^{-3}$ relaxes to plasma on a timescale of about 500 ns   Observations such as these agree well with the predictions of coupled rate-equation calculations   We can understand this variation in relaxation dynamics with $\rho_0$ and $n_0$ quite simply in terms of the corresponding density of prompt Penning electrons these conditions afford to initiate the avalanche to plasma   

Figure \ref{fig:scaled_rise} illustrates this, showing how rise times predicted by coupled rate-equation simulations for a large range of initial densities and principal quantum number match when plotted as a function of time scaled by the ultimate plasma frequency and fraction of prompt Penning electrons   The dashed line gives an approximate account of the scaled rate of avalanche under all conditions of Rydberg gas density and initial principal quantum number in terms of the simple sigmoidal function:

\begin{equation}
\frac{\rho_e}{\rho_0} = \frac{a}{b+e^{-c\tau}},
  \label{scaledEq1}
\end{equation}
where,
\begin{equation}
\tau = t \omega_e P_f^{3/4},
  \label{scaledEq2}
\end{equation}
in which $\omega_e$ is the plasma frequency after avalanche, $P_f$ is the fraction of prompt Penning electrons, and $a = 0 00062$,  $b =   0 00082$ and $c =     0 075$ are empirical coefficients   

\begin{figure}[h!]
\centering
\includegraphics[width=  4 \textwidth]{sim_analytical_density pdf}
   \caption{Rise in fractional electron density as a function of time scaled by the plasma frequency, $\omega_e$ and fraction, $\rho_e(t=0)/\rho_0 = P_f$, of prompt Penning electrons   Simulation results shown for $n_0 = 30$, 50 and 70 with initial densities, $\rho_0 = 10^9,~10^{10},~10^{11},~{\rm and}~10^{12}~{\rm cm}^{-3}$   
   }
\label{fig:scaled_rise}
\end{figure}


\subsection{Evolution to plasma in a Rydberg gas Gaussian ellipsoid}

As outlined above, the local density and principal quantum number together determine the rate at which a Rydberg gas avalanches to plasma   Our experiment crosses a 2 mm wide cylindrically Gaussian molecular beam with a 1 mm diameter TEM$_{00}$ $\omega_1$ laser beam to produce a Gaussian ellipsoidal distribution of molecules excited to the A $^2\Sigma^+$ $v=0, ~N'=0$ intermediate state   A larger diameter $\omega_2$ pulse then drives a second step that forms a Rydberg gas in a single $n_0f(2)$ state with the spatial distribution of the intermediate state   

We model this shaped Rydberg gas as a system of 100 concentric ellipsoidal shells of varying density \cite{haenelCP}   Coupled rate equations within each shell describe the avalanche to plasma   This rate process proceeds from shell to shell with successively longer induction periods, determined by the local density as detailed above   The rising conversion of Rydberg molecules to ions plus neutral dissociation products conserves the particle number in each shell   We assume that local space charge confines electrons to shells, conserving quasi-neutrality   Electrons exchange kinetic energy at the boundaries of each shell, which determines a single plasma electron temperature   

\begin{figure}[h!]
\centering
\includegraphics[width=  5 \textwidth]{shell_model_100}
   \caption{(top frame) Cross-sectional contour diagram in the $x,y$ plane for $z=0$ describing the distribution of ion plus electron density over 100 shells of Gaussian ellipsoid with initial dimensions, $\sigma_x= 0 75$ mm and $\sigma_y= \sigma_z = 0 42$ mm and an initial $n_0 = 50$ Rydberg gas density, $\rho_0 = 2 \times 10^{11}$ cm$^{3}$ after an evolution time of 100 ns   (bottom frame) Curves describing the (dashed) ascending ion and (solid) descending Rydberg gas densities of each shell as functions of evolution time, for $t=20$, 40, 60, 80 and 100 ns   
   }
\label{fig:shell}
\end{figure}

The upper frame of Figure \ref{fig:shell} shows contours of NO$^+$ ion density after 100 ns obtained from a shell-model coupled rate-equation simulation of the avalanche of a Gaussian ellipsoidal Rydberg gas of nitric oxide with a selected initial state, $50f(2)$ and a density of $2 \times 10^{11}$ cm$^{-3}$   Here, we simulate a relaxation that includes channels of predissociation at every Rydberg level and redistributes the energy released to electrons, which determines a uniform rising electron temperature for all shells   

For comparison, the lower frame plots curves describing the ion density of each shell as a function of time from 20 to 100 ns, as determined by applying Eq \ref{scaledEq1} for the local conditions of initial Rydberg gas density   This numerical approximation contains no provision for predissociation   Coupled rate-equation simulations for uniform volumes show that predissociation depresses yield to some degree, but has less effect on the avalanche kinetics \cite{Saquet2012}   Therefore, we can expect sets of numerically estimated shell densities, scaled to agree with the simulated ion density at the elapsed time of 100 ns to provide a reasonable account of the earlier NO$^+$ density profiles as a function of time    


\begin{figure}[h!]
\centering
\includegraphics[width=  4 \textwidth]{Shell_pop}
   \caption{Global population fractions of particles as they evolve in the avalanche of a shell-model ellipsoidal Rydberg gas with the initial principal quantum number and density distribution of Figure \ref{fig:shell}
   }
\label{fig:shell_yields}
\end{figure}

For each time step, the difference, $\rho_0 - \rho_e$ defines the neutral population of each shell   We assign a fraction of this population to surviving Rydberg molecules, such that the total population of NO$^*$ as a function of time agrees with the prediction of the shell-model simulation, as shown in Figure \ref{fig:shell_yields}   We consider the balance of this neutral population to reflect NO$^*$ molecules that have dissociated to form N($^4$S) $+$ O($^3$P)   Figure \ref{fig:shell} plots these surviving Rydberg densities as a function of radial distance for each evolution time   At the initial density of this simulation, note at each time step that a higher density of Rydberg molecules encloses the tail of the ion density distribution in $x$    

\subsection{Plasma expansion and NO$^+$ - NO$^*$ charge exchange as an avenue of quench}

We regard the ions as initially stationary   The release of electrons creates a radial electric potential gradient, which gives rise to a force, $-e\nabla \phi_{k,j}(t)$, that accelerates the ions in shell $j$ in direction $k$ according to \cite{Sadeghi 2012}:

\begin{align}
\frac{-e}{m'}\nabla \phi_{k,j}(t) = & \frac{\partial u_{k,j}(t)}{\partial t} \notag  \\
= & \frac{k_BT_e(t)}{m'\rho_j(t)} \frac{\rho_{j+1}(t) - \rho_j(t)}{r_{k,j+1}(t) - r_{k,j}(t)},
  \label{dr_dt}
\end{align}

\noindent where $\rho_j(t)$ represents the density of ions in shell $j$   

The instantaneous velocity, $u_{k,j}(t)$ determines the change in the radial coordinates of each shell, $r_{k,j}(t)$, 
\begin{equation}
\frac{\partial r_{k,j}(t)}{\partial t}=u_{k,j}(t) = \gamma_{k,j}(t) r_{k,j}(t),
  \label{dr_dt}
\end{equation}
\noindent which in turn determines shell volume and thus its density, $ \rho_j(t)$    
The electron temperature supplies the thermal energy that drives this ambipolar expansion   Ions accelerate and $T_e$ falls according to: 

\begin{equation}
\frac{3k_B}{2}\frac{\partial T_e(t)}{\partial t}= -\frac{m'}{\sum_{j}{N_j}}\sum_{k,j}{N_j u_{k,j}(t)\frac{\partial u_{k,j}(t)}{\partial t}},
  \label{dr_dt}
\end{equation}
\noindent where we define an effective ion mass, $m'$, that recognizes the redistribution of the electron expansion force over all the NO$^+$ charge centres by resonant ion-Rydberg charge exchange, which occurs with a very large cross section \cite{PPR}   
\begin{equation}
m' =\left (1+ \frac{\rho^*_{j}(t)}{ \rho_j(t)}\right) m ,
  \label{dr_dt}
\end{equation}
\noindent in which $\rho^*_{j}(t)$ represents the instantaneous Rydberg density in shell $j$ 

The initial avalanche in the high-density core of the ellipsoid leaves few Rydberg molecules, so this term has little initial effect   Rydberg molecules predominate in the lower-density wings   There, momentum sharing by charge exchange assumes a greater importance   

We see this most directly in the $\omega_2$ absorption spectrum of transitions to states in the $n_0 f(2)$ Rydberg series, detected as the long-lived signal that survives a flight time of 400 $\mu$s to reach the imaging detector   The balance between the rising density of ions and the falling density of Rydberg molecules depends on the initial density of electrons produced by prompt Penning ionization   As clear from Eq \ref{Eq:PenDens}, this Penning fraction depends sensitively on the principal quantum number, and for all principal quantum numbers, on the initial Rydberg gas density   

\begin{figure}[h!]
\centering
\includegraphics[width=  4 \textwidth]{w2_spectra}
   \caption{Double-resonant spectra of nitric oxide Rydberg states in the $nf$ series converging to NO$^+$ $v=0$, $N^+=2$ (designated, $nf(2)$), derived from the late-peak signal obtained after a flight time of 400 $\mu$s by scanning $\omega_2$ for $\omega_1$ tuned to NO A $^2\Sigma^+$ $v=0$, $N'=0$ for initial $nf(2)$ densities from top to bottom of 0 07, 0 10, 0 13, 0 19, 0 27, 0 30, 0 32 and $3 \times 10^{12}$ cm$^{3}$   
  }
\label{fig:w2_spectra}
\end{figure}

Figure \ref{fig:w2_spectra} shows a series of $\omega_2$ late-signal excitation spectra for a set of initial densities   Here, we see a clear consequence of the higher-order dependence of Penning fraction - and thus the NO$^+$ ion - NO$^*$ Rydberg molecule balance - on $n_0$, the $\omega_2$-selected Rydberg gas initial principal quantum number   This Penning-regulated NO$^+$ ion - NO$^*$ Rydberg molecule balance appears necessary as a critical factor in achieving the long ultracold plasma lifetime required to produce this signal   We are progressing in theoretical work that explains the stability apparently conferred by this balance   


\subsection{Bifurcation and arrested relaxation}

Ambipolar expansion quenches electron kinetic energy as the initially formed plasma expands   Core ions follow electrons into the wings of the Rydberg gas   There, recurring charge exchange between NO$^+$ ions and NO$^*$ Rydberg molecules redistributes the ambipolar force of the expanding electron gas, equalizing ion and Rydberg velocities   This momentum matching effectively channels electron energy through ion motion into the overall $\pm x$ motion of gas volumes in the laboratory   The internal kinetic energy of the plasma, which at this point is defined almost entirely by the ion-Rydberg relative motion, falls   Spatial correlation develops, and over a period of 500 ns, the system forms the plasma/high-Rydberg quasi-equilibrium dramatically evidenced by the SFI results in Figure \ref{fig:SFI}   

\begin{figure}[h!]
\centering
\includegraphics[width=  4 \textwidth]{Bifurcation pdf}
   \caption{$x,y$ detector images of ultracold plasma volumes produced by 2:1 aspect ratio ellipsoidal Rydberg gases with selected initial state, $40f(2)$ after a flight time of 402 $\mu$s over a distance of 575 mm   Lower frame displays the distribution in $x$ of the charge integrated in $y$ and $z$   Both images represent the unadjusted raw signal acquired in each case after 250 shots   
   }
\label{fig:bifurcation}
\end{figure}

In the wings, momentum redistribution owing to cycles of ion-Rydberg charge transfer retards radial expansion \cite{Pohl2003,PPR}   By redirecting electron energy from ambipolar acceleration to $\pm x$ plasma motion, NO$^+$ to NO$^*$ charge exchange dissipates electron thermal energy   This redistribution of energy released in the avalanche of the Rydberg gas to plasma, causes the ellipsoidal Rydberg gas to bifurcate \cite{Schulz-Weiling2016,Haenel2017}, forming very long-lived, separating charged-particle distributions   We capture the electron signal from these recoiling volumes on an imaging detector as pictured in Figure \ref{fig:bifurcation}   Here, momentum matching preserves density and enables ions and Rydberg molecules to relax to positions that minimize potential energy, building spatial correlation   

The semi-classical description of avalanche and relaxation outlined above forms an important point of reference from which to interpret our experimental observations   The laser crossed molecular beam illumination geometry creates a Rydberg gas with a distinctively shaped high-density spatial distribution   This initial condition has an evident effect on the evolution dynamics   We have developed semi-classical models that explicitly consider the coupled rate and hydrodynamic processes governing the evolution from Rydberg gas to plasma using a realistic, ellipsoidal representation of the ion/electron and Rydberg densities \cite{haenelCP}   No combination of initial conditions can produce a simulation that conforms classically with the state of arrested relaxation we observe experimentally  


\subsection{A molecular ultracold plasma state of arrested relaxation}

Thus, we find that spontaneous avalanche to plasma splits the core of an ellipsoidal Rydberg gas of nitric oxide  As ambipolar expansion quenches the electron temperature of this core plasma, long-range, resonant charge transfer from ballistic ions to frozen Rydberg molecules in the wings of the ellipsoid quenches the ion-Rydberg molecule relative velocity distribution  This sequence of steps gives rise to a remarkable mechanics of self-assembly, in which the kinetic energy of initially formed hot electrons and ions drives an observed separation of plasma volumes  These dynamics redistribute ion momentum, efficiently channeling electron energy into a reservoir of mass-transport  This starts a process that evidently anneals separating volumes to a state of cold, correlated ions, electrons and Rydberg molecules  

We have devised a three-dimensional spin model to describe this arrested state of the ultracold plasma in terms of two, three and four-level dipole-dipole energy transfer interactions (spin flip-flops), together with Ising interactions that arise from the concerted pairwise coupling of resonant pairs of dipoles \cite{SousMBL,SousNJP}   

The Hamiltonian includes the effects of onsite disorder owing to the broad spectrum of states populated in the ensemble and the unique electrostatic environment of every dipole   Extending ideas developed for simpler systems \cite{Burin1,Sondhi}, one can make a case for slow dynamics, including an arrest in the relaxation of NO Rydberg molecules to predissociating states of lower principal quantum number 

Systems of higher dimension ought to thermalize by energy transfer that spreads from rare but inevitable ergodic volumes (Griffiths regions) \cite{Sarang2, Roeck_griffith, RareRegions_rev, Thermal_inclusions}   However, a feature in the self-assembly of the molecular ultracold plasma may preclude destabilization by rare thermal domains:  Whenever the quenched plasma develops a delocalizing Griffiths region, the local predissociation of relaxing NO molecules promptly proceeds to deplete that region to a void of no consequence 

In summary, the classical dynamics of avalanche and bifurcation appear to create a quenched condition of low temperature and high disorder in which dipole-dipole interactions drive self-assembly to a localized state purified by the predissociation of thermal regions   We suggest that this state of the quenched ultracold plasma offers an experimental platform for studying quantum many-body physics of disordered systems  \\

\section{Acknowledgments}
This work was supported by the US Air Force Office of Scientific Research (Grant No  FA9550-17-1-0343), together with the Natural Sciences and Engineering research Council of Canada (NSERC), the Canada Foundation for Innovation (CFI) and the British Columbia Knowledge Development Fund (BCKDF)  


Context 2: Vitamin K - Wikipedia
(Redirected from Vitamin k)
This article needs more medical references for verification or relies too heavily on primary sources  Please review the contents of the article and add the appropriate references if you can  Unsourced or poorly sourced material may be challenged and removed  (November 2015)
This article is about the family of vitamers  For vitamin K1 the form usually used as a supplement, see Phytomenadione 
Vitamin K structures  MK-4 and MK-7 are both subtypes of K2 
Vitamin K deficiency, Warfarin overdose
Vitamin K is a group of structurally similar, fat-soluble vitamins the human body requires for complete synthesis of certain proteins that are prerequisites for blood coagulation and which the body also needs for controlling binding of calcium in bones and other tissues  The vitamin K-related modification of the proteins allows them to bind calcium ions, which they cannot do otherwise  Without vitamin K, blood coagulation is seriously impaired, and uncontrolled bleeding occurs  Low levels of vitamin K also weaken bones and promote calcification of arteries and other soft tissues[citation needed] 
Chemically, the vitamin K family comprises 2-methyl-1,4-naphthoquinone (3-) derivatives  Vitamin K includes two natural vitamers: vitamin K1 and vitamin K2 [1] Vitamin K2, in turn, consists of a number of related chemical subtypes, with differing lengths of carbon side chains made of isoprenoid groups of atoms 
Vitamin K1, also known as phylloquinone, is made by plants, and is found in highest amounts in green leafy vegetables because it is directly involved in photosynthesis  It may be thought of as the plant form of vitamin K  It is active as a vitamin in animals and performs the classic functions of vitamin K, including its activity in the production of blood-clotting proteins  Animals may also convert it to vitamin K2 
Bacteria in the gut flora can also convert K1 into vitamin K2  In addition, bacteria typically lengthen the isoprenoid side chain of vitamin K2 to produce a range of vitamin K2 forms, most notably the MK-7 to MK-11 homologues of vitamin K2  All forms of K2 other than MK-4 can only be produced by bacteria, which use these forms in anaerobic respiration  The MK-7 and other bacterially derived forms of vitamin K2 exhibit vitamin K activity in animals, but MK-7's extra utility over MK-4, if any, is unclear and is a matter of investigation 
Three synthetic types of vitamin K are known: vitamins K3, K4, and K5  Although the natural K1 and all K2 homologues and synthetic K4 and K5 have proven nontoxic, the synthetic form K3 (menadione) has shown toxicity [2]
1 2 Cardiovascular health
1 4 Coumarin poisoning
4 1 Conversion of vitamin K1 to vitamin K2
4 2 Vitamin K2
6 Absorption and dietary need
7 Dietary reference intake
10 Biochemistry
10 1 Function in animals
10 2 Gamma-carboxyglutamate proteins
10 3 Methods of assessment
10 4 Function in bacteria
11 Injection in newborns
11 3 Controversy
A review of 2014 concluded that there is positive evidence that monotherapy using MK-4, one of the forms of Vitamin K2, reduces fracture incidence in post-menopausal women with osteoporosis, and suggested further research on the combined use of MK-4 with bisphosphonates  In contrast, an earlier review article of 2013 concluded that there is no good evidence that vitamin K supplementation helps prevent osteoporosis or fractures in postmenopausal women [3]
A Cochrane systematic review of 2006 suggested that supplementation with Vitamin K1 and with MK4 reduces bone loss; in particular, a strong effect of MK-4 on incident fractures among Japanese patients was emphasized [4]
A review article of 2016 suggested to consider, as one of several measures for bone health, increasing the intake of foods rich in vitamins K1 and K2 [5]
Cardiovascular health[edit]
Adequate intake of vitamin K is associated with the inhibition of arterial calcification and stiffening,[6] but there have been few interventional studies and no good evidence that vitamin K supplementation is of any benefit in the primary prevention of cardiovascular disease [7]
One 10-year population study, the Rotterdam Study, did show a clear and significant inverse relationship between the highest intake levels of menaquinone (mainly MK-4 from eggs and meat, and MK-8 and MK-9 from cheese) and cardiovascular disease and all-cause mortality in older men and women [8]
Vitamin K has been promoted in supplement form with claims it can slow tumor growth; there is however no good medical evidence that supports such claims [9]
Coumarin poisoning[edit]
Vitamin K is part of the suggested treatment regime for poisoning by rodenticide (coumarin poisoning) [10]
Although allergic reaction from supplementation is possible, no known toxicity is associated with high doses of the phylloquinone (vitamin K1) or menaquinone (vitamin K2) forms of vitamin K, so no tolerable upper intake level (UL) has been set [11]
Blood clotting (coagulation) studies in humans using 45 mg per day of vitamin K2 (as MK-4)[12] and even up to 135 mg per day (45 mg three times daily) of K2 (as MK-4),[13] showed no increase in blood clot risk  Even doses in rats as high as 250 mg/kg, body weight did not alter the tendency for blood-clot formation to occur [14]
Unlike the safe natural forms of vitamin K1 and vitamin K2 and their various isomers, a synthetic form of vitamin K, vitamin K3 (menadione), is demonstrably toxic at high levels  The U S  FDA has banned this form from over-the-counter sale in the United States because large doses have been shown to cause allergic reactions, hemolytic anemia, and cytotoxicity in liver cells [2]
Phylloquinone (K1)[15][16] or menaquinone (K2) are capable of reversing the anticoagulant activity of the anticoagulant warfarin (tradename Coumadin)  Warfarin works by blocking recycling of vitamin K, so that the body and tissues have lower levels of active vitamin K, and thus a deficiency of vitamin K 
Supplemental vitamin K (for which oral dosing is often more active than injectable dosing in human adults) reverses the vitamin K deficiency caused by warfarin, and therefore reduces the intended anticoagulant action of warfarin and related drugs [17] Sometimes small amounts of vitamin K are given orally to patients taking warfarin so that the action of the drug is more predictable [17] The proper anticoagulant action of the drug is a function of vitamin K intake and drug dose, and due to differing absorption must be individualized for each patient [citation needed] The action of warfarin and vitamin K both require two to five days after dosing to have maximum effect, and neither warfarin or vitamin K shows much effect in the first 24 hours after they are given [18]
The newer anticoagulants dabigatran and rivaroxaban have different mechanisms of action that do not interact with vitamin K, and may be taken with supplemental vitamin K [19][20]
Vitamin K2 (menaquinone)  In menaquinone, the side chain is composed of a varying number of isoprenoid residues  The most common number of these residues is four, since animal enzymes normally produce menaquinone-4 from plant phylloquinone 
A sample of phytomenadione for injection, also called phylloquinone
The three synthetic forms of vitamin K are vitamins K3 (menadione), K4, and K5, which are used in many areas, including the pet food industry (vitamin K3) and to inhibit fungal growth (vitamin K5) [21]
Conversion of vitamin K1 to vitamin K2[edit]
Vitamin K1 (phylloquinone) – both forms of the vitamin contain a functional naphthoquinone ring and an aliphatic side chain  Phylloquinone has a phytyl side chain 
The MK-4 form of vitamin K2 is produced by conversion of vitamin K1 in the testes, pancreas, and arterial walls [22] While major questions still surround the biochemical pathway for this transformation, the conversion is not dependent on gut bacteria, as it occurs in germ-free rats[23][24] and in parenterally-administered K1 in rats [25][26] In fact, tissues that accumulate high amounts of MK-4 have a remarkable capacity to convert up to 90% of the available K1 into MK-4 [27][28] There is evidence that the conversion proceeds by removal of the phytyl tail of K1 to produce menadione as an intermediate, which is then condensed with an activated geranylgeranyl moiety (see also prenylation) to produce vitamin K2 in the MK-4 (menatetrione) form [29]
Vitamin K2[edit]
Main article: Vitamin K2
Vitamin K2 (menaquinone) includes several subtypes  The two subtypes most studied are menaquinone-4 (menatetrenone, MK-4) and menaquinone-7 (MK-7) 
Vitamin K1, the precursor of most vitamin K in nature, is a stereoisomer of phylloquinone, an important chemical in green plants, where it functions as an electron acceptor in photosystem I during photosynthesis  For this reason, vitamin K1 is found in large quantities in the photosynthetic tissues of plants (green leaves, and dark green leafy vegetables such as romaine lettuce, kale and spinach), but it occurs in far smaller quantities in other plant tissues (roots, fruits, etc )  Iceberg lettuce contains relatively little  The function of phylloquinone in plants appears to have no resemblance to its later metabolic and biochemical function (as "vitamin K") in animals, where it performs a completely different biochemical reaction 
Vitamin K (in animals) is involved in the carboxylation of certain glutamate residues in proteins to form gamma-carboxyglutamate (Gla) residues  The modified residues are often (but not always) situated within specific protein domains called Gla domains  Gla residues are usually involved in binding calcium, and are essential for the biological activity of all known Gla proteins [30]
At this time[update], 17 human proteins with Gla domains have been discovered, and they play key roles in the regulation of three physiological processes:
Blood coagulation: prothrombin (factor II), factors VII, IX, and X, and proteins C, S, and Z[31]
Bone metabolism: osteocalcin, also called bone Gla protein (BGP), matrix Gla protein (MGP),[32] periostin,[33] and the recently discovered Gla-rich protein (GRP) [34][35]
Vascular biology: growth arrest-specific protein 6 (Gas6)[36]
Unknown function: proline-rich γ-carboxyglutamyl proteins (PRGPs) 1 and 2, and transmembrane γ-carboxy glutamyl proteins (TMGs) 3 and 4 [37]
Like other lipid-soluble vitamins (A, D and E), vitamin K is stored in the fatty tissue of the human body 
Absorption and dietary need[edit]
Previous theory held that dietary deficiency is extremely rare unless the small intestine was heavily damaged, resulting in malabsorption of the molecule  Another at-risk group for deficiency were those subject to decreased production of K2 by normal intestinal microbiota, as seen in broad spectrum antibiotic use [38] Taking broad-spectrum antibiotics can reduce vitamin K production in the gut by nearly 74% in people compared with those not taking these antibiotics [39] Diets low in vitamin K also decrease the body's vitamin K concentration [40] Those with chronic kidney disease are at risk for vitamin K deficiency, as well as vitamin D deficiency, and particularly those with the apoE4 genotype [41] Additionally, in the elderly there is a reduction in vitamin K2 production [42]
The National Academy of Medicine (NAM) updated an estimate of what constitutes an adequate intake (AI) for vitamin K in 2001  The NAM does not distinguish between K1 and K2 – both are counted as vitamin K  At that time there was not sufficient evidence to set the more rigorous estimated average requirement (EAR) or recommended dietary allowance (RDA) given for most of the essential vitamins and minerals  The current daily AIs for vitamin K for adult women and men are 90 μg and 120 μg respectively  The AI for pregnancy and lactation is 90 μg  For infants up to 12 months the AI is 2–2 5 μg, and for children aged 1 to 18 years the AI increases with age from 30 to 75 μg  As for safety, the FNB also sets tolerable upper intake levels (known as ULs) for vitamins and minerals when evidence is sufficient  In the case of vitamin K no UL is set, as evidence for adverse effects is not sufficient  Collectively EARs, RDAs, AIs and ULs are referred to as dietary reference intakes [43] The European Food Safety Authority reviewed the same safety question and did not set an UL [44]
For U S  food and dietary supplement labeling purposes, the amount in a serving is expressed as a percentage of daily value (%DV)  For vitamin K labeling purposes the daily value was 80 μg, but as of May 2016 it has been revised upwards to 120 μg  A table of the pre-change adult daily values is provided at reference daily intake  Food and supplement companies have until 28 July 2018 to comply with the change 
See also: Vitamin K2 § Dietary sources
K1 (μg)[45]
Kale, cooked
Collards, cooked
Collards, raw
Swiss chard, cooked
Swiss chard, raw
Turnip greens, raw
Romaine lettuce, raw
Table from "Important information to know when you are taking: Warfarin (Coumadin) and Vitamin K", Clinical Center, National Institutes of Health Drug Nutrient Interaction Task Force [46]
Vitamin K1 is found chiefly in leafy green vegetables such as dandelion greens (which contain 778 4 μg per 100 g, or 741% of the recommended daily amount), spinach, swiss chard, lettuce and Brassica vegetables (such as cabbage, kale, cauliflower, broccoli, and brussels sprouts) and often the absorption is greater when accompanied by fats such as butter or oils; some fruits, such as avocados, kiwifruit and grapes, are also high in vitamin K  By way of reference, two tablespoons of parsley contains 153% of the recommended daily amount of vitamin K [47] Some vegetable oils, notably soybean oil, contain vitamin K, but at levels that would require relatively large calorie consumption to meet the USDA-recommended levels [48] colonic bacteria synthesize a significant portion of humans' vitamin K needs; newborns often receive a vitamin K shot at birth to tide them over until their colons become colonized at five to seven days of age from the consumption of breast milk 
The tight binding of vitamin K1 to thylakoid membranes in chloroplasts makes it less bioavailable  For example, cooked spinach has a 5% bioavailability of phylloquinone, however, fat added to it increases bioavailability to 13% due to the increased solubility of vitamin K in fat [49]
Main article: Vitamin K deficiency
Average diets are usually not lacking in vitamin K, and primary deficiency is rare in healthy adults  Newborn infants are at an increased risk of deficiency  Other populations with an increased prevalence of vitamin K deficiency include those who suffer from liver damage or disease (e g  alcoholics), cystic fibrosis, or inflammatory bowel diseases, or have recently had abdominal surgeries  Secondary vitamin K deficiency can occur in people with bulimia, those on stringent diets, and those taking anticoagulants  Other drugs associated with vitamin K deficiency include salicylates, barbiturates, and cefamandole, although the mechanisms are still unknown  Vitamin K1 deficiency can result in coagulopathy, a bleeding disorder [50]Symptoms of K1 deficiency include anemia, bruising, nosebleeds and bleeding of the gums in both sexes, and heavy menstrual bleeding in women 
Osteoporosis[51][52] and coronary heart disease[53][54] are strongly associated with lower levels of K2 (menaquinone)  Vitamin K2 (as menaquinones MK-4 through MK-10) intake level is inversely related to severe aortic calcification and all-cause mortality [8]
Function in animals[edit]
Mechanism of action of vitamin K1 
The function of vitamin K2 in the animal cell is to add a carboxylic acid functional group to a glutamate (Glu) amino acid residue in a protein, to form a gamma-carboxyglutamate (Gla) residue  This is a somewhat uncommon posttranslational modification of the protein, which is then known as a "Gla protein"  The presence of two −COOH (carboxylic acid) groups on the same carbon in the gamma-carboxyglutamate residue allows it to chelate calcium ions  The binding of calcium ions in this way very often triggers the function or binding of Gla-protein enzymes, such as the so-called vitamin K-dependent clotting factors discussed below 
Within the cell, vitamin K undergoes electron reduction to a reduced form called vitamin K hydroquinone, catalyzed by the enzyme vitamin K epoxide reductase (VKOR) [55] Another enzyme then oxidizes vitamin K hydroquinone to allow carboxylation of Glu to Gla; this enzyme is called gamma-glutamyl carboxylase[56][57] or the vitamin K-dependent carboxylase  The carboxylation reaction only proceeds if the carboxylase enzyme is able to oxidize vitamin K hydroquinone to vitamin K epoxide at the same time  The carboxylation and epoxidation reactions are said to be coupled  Vitamin K epoxide is then reconverted to vitamin K by VKOR  The reduction and subsequent reoxidation of vitamin K coupled with carboxylation of Glu is called the vitamin K cycle [58] Humans are rarely deficient in vitamin K1 because, in part, vitamin K1 is continuously recycled in cells [59]
Warfarin and other 4-hydroxycoumarins block the action of VKOR [60] This results in decreased concentrations of vitamin K and vitamin K hydroquinone in tissues, such that the carboxylation reaction catalyzed by the glutamyl carboxylase is inefficient  This results in the production of clotting factors with inadequate Gla  Without Gla on the amino termini of these factors, they no longer bind stably to the blood vessel endothelium and cannot activate clotting to allow formation of a clot during tissue injury  As it is impossible to predict what dose of warfarin will give the desired degree of clotting suppression, warfarin treatment must be carefully monitored to avoid overdose 
Gamma-carboxyglutamate proteins[edit]
Main article: Gla domain
The following human Gla-containing proteins ("Gla proteins") have been characterized to the level of primary structure: blood coagulation factors II (prothrombin), VII, IX, and X, anticoagulant proteins C and S, and the factor X-targeting protein Z  The bone Gla protein osteocalcin, the calcification-inhibiting matrix Gla protein (MGP), the cell growth regulating growth arrest specific gene 6 protein (Gas6), and the four transmembrane Gla proteins (TMGPs), the function of which is at present unknown  Gas6 can function as a growth factor to activate the Axl receptor tyrosine kinase and stimulate cell proliferation or prevent apoptosis in some cells  In all cases in which their function was known, the presence of the Gla residues in these proteins turned out to be essential for functional activity 
Gla proteins are known to occur in a wide variety of vertebrates: mammals, birds, reptiles, and fish  The venom of a number of Australian snakes acts by activating the human blood-clotting system  In some cases, activation is accomplished by snake Gla-containing enzymes that bind to the endothelium of human blood vessels and catalyze the conversion of procoagulant clotting factors into activated ones, leading to unwanted and potentially deadly clotting 
Another interesting class of invertebrate Gla-containing proteins is synthesized by the fish-hunting snail Conus geographus [61] These snails produce a venom containing hundreds of neuroactive peptides, or conotoxins, which is sufficiently toxic to kill an adult human  Several of the conotoxins contain two to five Gla residues [62]
Methods of assessment[edit]
Vitamin K status can be assessed by:
The prothrombin time (PT) test measures the time required for blood to clot  A blood sample is mixed with citric acid and put in a fibrometer; delayed clot formation indicates a deficiency  This test is insensitive to mild deficiency, as the values do not change until the concentration of prothrombin in the blood has declined by at least 50% [63]
Undercarboxylated prothrombin (PIVKA-II); in a study of 53 newborns, found "PT (prothrombin time) is a less sensitive marker than PIVKA II",[64] and as indicated above, PT is unable to detect subclinical deficiencies that can be detected with PIVKA-II testing 
Plasma phylloquinone was found to be positively correlated with phylloquinone intake in elderly British women, but not men,[65] but an article by Schurgers et al  reported no correlation between FFQ[further explanation needed] and plasma phylloquinone [66]
Urinary γ-carboxyglutamic acid responds to changes in dietary vitamin K intake  Several days are required before any change can be observed  In a study by Booth et al , increases of phylloquinone intakes from 100 μg to between 377 and 417 μg for five days did not induce a significant change  Response may be age-specific [67]
Undercarboxylated osteocalcin (UcOc) levels have been inversely correlated with stores of vitamin K[68] and bone strength in developing rat tibiae  Another study following 78 post-menopausal Korean women found a supplement regimen of vitamins K and D, and calcium, but not a regimen of vitamin D and calcium, was inversely correlated with reduced UcOc levels [69]
Function in bacteria[edit]
Many bacteria, such as Escherichia coli found in the large intestine, can synthesize vitamin K2 (menaquinone-7 or MK-7, up to MK-11),[70] but not vitamin K1 (phylloquinone)  In these bacteria, menaquinone transfers two electrons between two different small molecules, during oxygen-independent metabolic energy production processes (anaerobic respiration) [71] For example, a small molecule with an excess of electrons (also called an electron donor) such as lactate, formate, or NADH, with the help of an enzyme, passes two electrons to menaquinone  The menaquinone, with the help of another enzyme, then transfers these two electrons to a suitable oxidant, such fumarate or nitrate (also called an electron acceptor)  Adding two electrons to fumarate or nitrate converts the molecule to succinate or nitrite plus water, respectively 
Some of these reactions generate a cellular energy source, ATP, in a manner similar to eukaryotic cell aerobic respiration, except the final electron acceptor is not molecular oxygen, but fumarate or nitrate  In aerobic respiration, the final oxidant is molecular oxygen (O2), which accepts four electrons from an electron donor such as NADH to be converted to water  E  coli, as facultative anaerobes, can carry out both aerobic respiration and menaquinone-mediated anaerobic respiration 
Injection in newborns[edit]
The blood clotting factors of newborn babies are roughly 30–60% that of adult values; this may be due to the reduced synthesis of precursor proteins and the sterility of their guts  Human milk contains 1–4 μg/L of vitamin K1, while formula-derived milk can contain up to 100 μg/L in supplemented formulas  Vitamin K2 concentrations in human milk appear to be much lower than those of vitamin K1  Occurrence of vitamin K deficiency bleeding in the first week of the infant's life is estimated at 0 25–1 7%, with a prevalence of 2–10 cases per 100,000 births [72] Premature babies have even lower levels of the vitamin, so they are at a higher risk from this deficiency 
Bleeding in infants due to vitamin K deficiency can be severe, leading to hospitalization, blood transfusions, brain damage, and death  Supplementation can prevent most cases of vitamin K deficiency bleeding in the newborn  Intramuscular administration is more effective in preventing late vitamin K deficiency bleeding than oral administration [73][74]
As a result of the occurrences of vitamin K deficiency bleeding, the Committee on Nutrition of the American Academy of Pediatrics has recommended 0 5–1 mg of vitamin K1 be administered to all newborns shortly after birth [74]
In the UK vitamin K supplementation is recommended for all newborns within the first 24 hours [75] This is usually given as a single intramuscular injection of 1 mg shortly after birth but as a second-line option can be given by three oral doses over the first month [76]
Controversy arose in the early 1990s regarding this practice, when two studies suggested a relationship between parenteral administration of vitamin K and childhood cancer,[77] however, poor methods and small sample sizes led to the discrediting of these studies, and a review of the evidence published in 2000 by Ross and Davies found no link between the two [78] Doctors reported emerging concerns in 2013,[79] after treating children for serious bleeding problems  They cited lack-of newborn vitamin K administration, as the reason that the problems occurred, and recommended that breastfed babies could have an increased risk unless they receive a preventative dose 
In the early 1930s, Danish scientist Henrik Dam investigated the role of cholesterol by feeding chickens a cholesterol-depleted diet [80] He initially replicated experiments reported by scientists at the Ontario Agricultural College (OAC) [81] McFarlane, Graham and Richardson, working on the chick feed program at OAC, had used chloroform to remove all fat from chick chow  They noticed that chicks fed only fat-depleted chow developed hemorrhages and started bleeding from tag sites [82] Dam found that these defects could not be restored by adding purified cholesterol to the diet  It appeared that – together with the cholesterol – a second compound had been extracted from the food, and this compound was called the coagulation vitamin  The new vitamin received the letter K because the initial discoveries were reported in a German journal, in which it was designated as Koagulationsvitamin  Edward Adelbert Doisy of Saint Louis University did much of the research that led to the discovery of the structure and chemical nature of vitamin K [83] Dam and Doisy shared the 1943 Nobel Prize for medicine for their work on vitamin K (K1 and K2) published in 1939  Several laboratories synthesized the compound(s) in 1939 [84]
For several decades, the vitamin K-deficient chick model was the only method of quantifying vitamin K in various foods: the chicks were made vitamin K-deficient and subsequently fed with known amounts of vitamin K-containing food  The extent to which blood coagulation was restored by the diet was taken as a measure for its vitamin K content  Three groups of physicians independently found this: Biochemical Institute, University of Copenhagen (Dam and Johannes Glavind), University of Iowa Department of Pathology (Emory Warner, Kenneth Brinkhous, and Harry Pratt Smith), and the Mayo Clinic (Hugh Butt, Albert Snell, and Arnold Osterberg) [85]
The first published report of successful treatment with vitamin K of life-threatening hemorrhage in a jaundiced patient with prothrombin deficiency was made in 1938 by Smith, Warner, and Brinkhous [86]
The precise function of vitamin K was not discovered until 1974, when three laboratories (Stenflo et al ,[87] Nelsestuen et al ,[88] and Magnusson et al [89]) isolated the vitamin K-dependent coagulation factor prothrombin (factor II) from cows that received a high dose of a vitamin K antagonist, warfarin  It was shown that, while warfarin-treated cows had a form of prothrombin that contained 10 glutamate (Glu) amino acid residues near the amino terminus of this protein, the normal (untreated) cows contained 10 unusual residues that were chemically identified as γ-carboxyglutamate (Gla)  The extra carboxyl group in Gla made clear that vitamin K plays a role in a carboxylation reaction during which Glu is converted into Gla 
The biochemistry of how vitamin K is used to convert Glu to Gla has been elucidated over the past thirty years in academic laboratories throughout the world 
^ "Vitamin K Overview"  University of Maryland Medical Center  ^ a b Higdon, Jane (Feb 2008)  "Vitamin K"  Linus Pauling Institute, Oregon State University  Retrieved 12 Apr 2008  ^ Hamidi, M  S ; Gajic-Veljanoski, O ; Cheung, A  M  (2013)  "Vitamin K and bone health"  Journal of Clinical Densitometry (Review)  16 (4): 409–413  doi:10 1016/j jocd 2013 08 017  PMID 24090644  ^ Cockayne, S ; Adamson, J ; Lanham-New, S ; Shearer, M  J ; Gilbody, S; Torgerson, D  J  (Jun 2006)  "Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials"  Archives of Internal Medicine (Review)  166 (12): 1256–1261  doi:10 1001/archinte 166 12 1256  PMID 16801507  ^ O'Keefe, J  H ; Bergman, N ; Carrera Bastos, P ; Fontes Villalba, M ; Di Nicolantonio, J  J ; Cordain, L  (2016)  "Nutritional strategies for skeletal and cardiovascular health: hard bones, soft arteries, rather than vice versa"  Open Heart (Review)  3 (1): e000325  doi:10 1136/openhrt-2015-000325  PMC 4809188  PMID 27042317  ^ Maresz, K  (Feb 2015)  "Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health"  Integrative Medicine (Review)  14 (1): 34–39  PMC 4566462  PMID 26770129  ^ Hartley, L ; Clar, C ; Ghannam, O ; Flowers, N ; Stranges, S ; Rees, K  (Sep 2015)  "Vitamin K for the primary prevention of cardiovascular disease"  The Cochrane Database of Systematic Reviews (Systematic review)  9 (9): CD011148  doi:10 1002/14651858 CD011148 pub2  PMID 26389791  ^ a b Geleijnse, J  M ; Vermeer, C ; Grobbee, D  E ; Schurgers, L  J ; Knapen, M  H ; van der Meer, I  M ; Hofman, A ; Witteman, J  C  (Nov 2004)  "Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study"  Journal of Nutrition  134 (11): 3100–3105  PMID 15514282  ^ Ades, T  B , ed  (2009)  "Vitamin K"  American Cancer Society Complete Guide to Complementary and Alternative Cancer Therapies (2nd ed )  American Cancer Society  pp  558–563  ISBN 978-0-944235-71-3  ^ Lung, D  (Dec 2015)  Tarabar, A , ed  "Rodenticide Toxicity Treatment & Management"  Medscape  WebMD  ^ Rasmussen, S  E ; Andersen, N  L ; Dragsted, L  O ; Larsen, J  C  (Mar 2006)  "A safe strategy for addition of vitamins and minerals to foods"  European Journal of Nutrition  45 (3): 123–135  doi:10 1007/s00394-005-0580-9  PMID 16200467  ^ Ushiroyama, T ; Ikeda, A ; Ueki, M (Mar 2002)  "Effect of continuous combined therapy with vitamin K2 and vitamin D3 on bone mineral density and coagulofibrinolysis function in postmenopausal women"  Maturitas  41 (3): 211–221  doi:10 1016/S0378-5122(01)00275-4  PMID 11886767  ^ Asakura, H ; Myou, S ; Ontachi, Y ; Mizutani, T ; Kato, M ; Saito, M ; Morishita, E ; Yamazaki, M ; Nakao, S  (Dec 2001)  "Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency"  Osteoporosis International  12 (12): 996–1000  doi:10 1007/s001980170007  PMID 11846334  ^ Ronden, J  E ; Groenen-van Dooren, M  M ; Hornstra, G ; Vermeer, C  (Jul 1997)  "Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains"  Atherosclerosis  132 (1): 61–67  doi:10 1016/S0021-9150(97)00087-7  PMID 9247360  ^ Ansell, J ; Hirsh, J ; Poller, L ; Bussey, H ; Jacobson, A ; Hylek, E (Sep 2004)  "The pharmacology and management of the vitamin K antagonists: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy"  Chest  126 (3 Suppl ): 204S–233S  doi:10 1378/chest 126 3_suppl 204S  PMID 15383473  ^ Crowther, M  A ; Douketis, J  D ; Schnurr, T ; Steidl, L ; Mera, V ; Ultori, C ; Venco, A ; Ageno, W  (Aug 2002)  "Oral vitamin K lowers the international normalized ratio more rapidly than subcutaneous vitamin K in the treatment of warfarin-associated coagulopathy  A randomized, controlled trial"  Annals of Internal Medicine  137 (4): 251–254  doi:10 7326/0003-4819-137-4-200208200-00009  PMID 12186515  ^ a b "Important Information to Know When You Are Taking: Warfarin (Coumadin) and Vitamin K" (PDF)  National Institute of Health Clinical Center Drug-Nutrient Interaction Task Force  Retrieved 17 Apr 2015  ^ "Guidelines For Warfarin Reversal With Vitamin K" (PDF)  American Society of Health-System Pharmacists  Retrieved 17 Apr 2015  ^ "Pradaxa Drug Interactions"  Pradaxapro com  19 Mar 2012  Retrieved 21 Apr 2013  ^ Bauersachs, R ; Berkowitz, S  D ; Brenner, B ; Buller, H  R ; Decousus, H ; Gallus, A  S ; Lensing, A  W ; Misselwitz, F ; Prins, M  H ; Raskob, G  E ; Segers, A ; Verhamme, P ; Wells, P ; Agnelli, G ; Bounameaux, H ; Cohen, A ; Davidson, B  L ; Piovella, F ; Schellong, S  (Dec 2010)  "Oral rivaroxaban for symptomatic venous thromboembolism"  New England Journal of Medicine  363 (26): 2499–2510  doi:10 1056/NEJMoa1007903  PMID 21128814  ^ McGee, W  (1 Feb 2007)  "Vitamin K"  MedlinePlus  Retrieved 2 Apr 2009  ^ Shearer, M  J ; Newman, P  (Oct 2008)  "Metabolism and cell biology of vitamin K"  Thrombosis and Haemostasis  100 (4): 530–547  doi:10 1160/TH08-03-0147  PMID 18841274  ^ Davidson, R  T ; Foley, A  L ; Engelke, J  A ; Suttie, J  W  (Feb 1998)  "Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria"  Journal of Nutrition  128 (2): 220–223  PMID 9446847  ^ Ronden, J  E ; Drittij-Reijnders, M  J ; Vermeer, C ; Thijssen, H  H  (Jan 1998)  "Intestinal flora is not an intermediate in the phylloquinone–menaquinone-4 conversion in the rat"  Biochimica et Biophysica Acta  1379 (1): 69–75  doi:10 1016/S0304-4165(97)00089-5  PMID 9468334  ^ Thijssen, H   H ; Drittij-Reijnders, M  J  (Sep 1994)  "Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4"  The British Journal of Nutrition  72 (3): 415–425  doi:10 1079/BJN19940043  PMID 7947656  ^ Will, B  H ; Usui, Y ; Suttie, J  W  (Dec 1992)  "Comparative metabolism and requirement of vitamin K in chicks and rats"  Journal of Nutrition  122 (12): 2354–2360  PMID 1453219  ^ Davidson, R  T ; Foley, A  L ; Engelke, J  A ; Suttie, J  W  (Feb 1998)  "Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria"  Journal of Nutrition  128 (2): 220–223  PMID 9446847  ^ Ronden, J  E ; Drittij-Reijnders, M  J ; Vermeer, C ; Thijssen, H  H  (Jan 1998)  "Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat"  Biochimica et Biophysica Acta  1379 (1): 69–75  doi:10 1016/S0304-4165(97)00089-5  PMID 9468334  ^ Al Rajabi, Ala (2011)  The Enzymatic Conversion of Phylloquinone to Menaquinone-4 (PhD thesis)  Tufts University, Friedman School of Nutrition Science and Policy  ^ Furie, B ; Bouchard, B  A ; Furie, B  C  (Mar 1999)  "Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid"  Blood  93 (6): 1798–1808  PMID 10068650  ^ Mann, K  G  (Aug 1999)  "Biochemistry and physiology of blood coagulation"  Thrombosis and Haemostasis  82 (2): 165–174  PMID 10605701  ^ Price, P  A  (1988)  "Role of vitamin-K-dependent proteins in bone metabolism"  Annual Review of Nutrition  8: 565–583  doi:10 1146/annurev nu 08 070188 003025  PMID 3060178  ^ Coutu, D  L ; Wu, J  H ; Monette, A ; Rivard, G  E ; Blostein, M  D ; Galipeau, J (Jun 2008)  "Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells"  Journal of Biological Chemistry  283 (26): 17991–18001  doi:10 1074/jbc M708029200  PMID 18450759  ^ Viegas, C  S ; Simes, D  C ; Laizé, V ; Williamson, M  K ; Price, P  A ; Cancela, M  L  (Dec 2008)  "Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates"  Journal of Biological Chemistry
Context 3: We want to make sure you completely understand what using Broadjam is all about  So please email us at info@broadjam com if anything is unclear 
THIS AGREEMENT IS A CONTRACT 
IT CONTAINS IMPORTANT INFORMATION REGARDING YOUR LEGAL RIGHTS, REMEDIES AND OBLIGATIONS, INCLUDING VARIOUS LIMITATIONS AND EXCLUSIONS 
PLEASE READ THIS AGREEMENT CAREFULLY, AND PRINT IT, BEFORE CLICKING "I ACCEPT"
SIGNING UP FOR A BROADJAM ACCOUNT MEANS YOU ACCEPT THIS AGREEMENT AND UNDERSTAND THAT IT WILL BIND YOU LEGALLY  BROWSING THE SITE WITHOUT AN ACCOUNT ALSO BINDS YOU TO APPLICABLE PROVISIONS OF THIS AGREEMENT 
You acknowledge that you have read, understand and agree to be bound by this Agreement  If you do not agree with any provision of this Agreement, do not use the Site or any Service 
As between you (whether you are an individual representing yourself, or acting as the representative for a group, band, business entity or association) and Broadjam, Inc , (referred to as "we," "us" or "Broadjam"), this Agreement contains the terms and conditions that govern your use of the website found at www broadjam com, any and all of its mobile version(s) and/or applications, any of its sub-domains (collectively, the "Site"), as well as any authorized activity made available by us to Users (each a "Service" and collectively, the "Services")  Unless otherwise indicated, the term "Site" shall include the Services and Site Content (as defined herein), and the term "Services" includes Mobile Services  Some particularized Services may be subject to additional terms and conditions set forth in separate agreements  Broadjam is a Delaware corporation with its principal place of business at PO Box 930556 Verona, WI 53593  You and Broadjam may be referred to collectively herein as the "Parties" and individually as a "Party "
1 04 Policies; Materials; Intellectual Property 
1 05 Co-Branding, Framing, Metatags and Linking 
1 07 Digital Millennium Copyright Act (DMCA) Policy 
1 12 Copyright and Trademark Notices 
1 14 Special Admonitions for International Use 
1 16 Links or Pointers to Other Sites 
1 18 Modifications to Agreement and Services 
1 20 Acceptance of Electronic Contract 
2 02 Term and Service Benefits 
2 03 Accuracy and Posting of Information and Materials 
2 06 Modifications to Subscriber's Account 
3 03 Hosting Subscriber's Representations, Warranties and Obligations 
4 06 Complimentary Weekly Submission Credits 
4 07 Complimentary Monthly Submission Credits 
4 10 Broadjam Music Software Refunds 
This Agreement applies generally to all Users  Provisions applying only to certain types of Users (such as Subscribers and Hosting Subscribers) are so designated 
We may change or modify this Agreement at any time and such changes or modifications will become effective upon being posted to the Site  We will indicate at the top of its first page the date this Agreement was last revised  If you do not agree to abide by this or any future versions of the Agreement, do not use or access (or continue to use or access) the Site or Services  It is your responsibility to check the Site regularly to determine if there have been changes to the Agreement and to review such changes  Without limiting the foregoing: if we make changes to the Agreement that we deem to be material, those with Broadjam accounts will receive a message in their Broadjam inbox  If you do not have a Broadjam account, you will not receive this direct message 
(a) "Artist" means any individual or group, whether or not organized as a legal entity, that made any creative contribution to Materials you post at, on or through the Site 
(b) "Person" means any individual, corporation, partnership, association or other group of persons, whether or not organized as a legal entity, including legal successors or representatives of the foregoing 
(c) "Materials" means any and all works of authorship posted to the Site by any User, whether copyrightable or not, including but not limited to sound recordings, musical compositions, lyrics, pictures, graphics, photographs, text, videos and other audiovisual work, album and other artwork, liner notes, compilations, derivative works and collective works 
(d) "User" means any Person who visits the Site for any purpose, authorized or unauthorized  The term, "User" includes but is not limited to those who submit Material to or in any manner avail themselves of any Service offered at, on or through the Site  The term, "User" also includes but is not limited to, Subscribers and Hosting Subscribers 
(e) "Term" means the period of time during which this Agreement is in effect as between Broadjam and You  Termination of your Broadjam account for any reason shall terminate the Term  Termination shall not be effective with respect to any provision of this Agreement that is either specifically designated as surviving termination, or should reasonably survive in order to accomplish the objectives of this Agreement 
(b) Broadjam shall have the right to review all Materials and in its sole discretion to remove or refuse to post any Materials for any reason 
(c) Except for Materials, the entire Site and its contents, including but not limited to text, graphics, logos, layout, design, button icons, images, compilations, object code, source code, multimedia content (including but not limited to images, illustrations, audio and video clips), html and other mark up languages, all scripts within the Site or associated therewith and all other work and intellectual property of any type or kind, whether patentable or copyrightable or not (hereinafter, without limitation, "Site Content"), is the property of Broadjam or its content suppliers and are protected by United States and international copyright laws with All Rights Reserved  All Site databases and the compilation of any/all Site Content are the exclusive property of Broadjam and are protected by United States and international copyright laws with All Rights Reserved  All software used on the Site or incorporated into it is the property of Broadjam or its software suppliers and is protected by United States and international copyright laws with All Rights Reserved 
(d) The Site is protected by all applicable federal and international intellectual property laws  No portion of the Site may be reprinted, republished, modified or distributed in any form without Broadjam's express written permission  You agree not to reproduce, reverse engineer, decompile, disassemble or modify any portion of the Site  Certain content may be licensed from third parties and all such third party content and all intellectual property rights related to such content belong to the respective third parties 
(e) You acknowledge that Broadjam retains exclusive ownership of the Site and all intellectual property rights associated therewith  Except as expressly provided herein, you are not granted any rights or license to patents, copyrights, trade secrets or trademarks with respect to the Site or any Service, and Broadjam reserves all rights not expressly granted hereunder  You shall promptly notify Broadjam in writing upon your discovery of any unauthorized use or infringement of the Site or any Service or Broadjam's patents, copyrights, trade secrets, trademarks or other intellectual property rights  The Site contains proprietary and confidential information that is protected by copyright laws and international treaty provisions 
(f) Violations of this Agreement may result in civil or criminal liability  We have the right to investigate occurrences, which may involve such violations and may involve, provide information to and cooperate with, law enforcement authorities in prosecuting users who are involved in such violations 
(h) If applicable, You agree to comply with the Acceptable Use Policies ("AUPs") of vendors providing bandwidth, merchant or related services to Broadjam  Broadjam will provide links to applicable AUPs upon your written request 
(i) "Broadjam," "Broadjam Top 10," "Metajam", "broadjam com", "Musicians of Broadjam," Mini MoB, PRIMO MoB and all other trademarks, service marks, logos, labels, product names, service names and trade dress appearing on the Site, registered and unregistered (collectively, the "Marks") are owned exclusively or are licensed by Broadjam  Marks not owned by Broadjam or its subsidiaries are the property of their respective owners, who may or may not be affiliated with, connected to, or sponsored by Broadjam  Other trademarks, service marks, logos, labels, product names and service names appearing in Material posted on the Site and not owned by Broadjam or its organizational affiliates, are the property of their respective owners  You agree not to copy, display or otherwise use any Marks without Broadjam's prior written permission  The Marks may never be used in any manner likely to cause confusion, disparage or dilute the Marks and/or in connection with any product or service that is not authorized or sponsored by Broadjam 
(j) You may not remove or alter, or cause to be removed or altered, any copyright, trademark, trade name, service mark, or any other proprietary notice or legend appearing on the Site 
Co-Branding  You may not co-brand the Site  For purposes of this Agreement, "co-branding" means to display a name, logo, trademark, or other means of attribution or identification of Broadjam in such a manner as is reasonably likely to give the impression that you have the right to display, publish,or distribute the Site or content accessible within the Site, including but not limited to Materials  You agree to cooperate with Broadjam in causing any unauthorized co-branding immediately to cease 
You may not frame or use framing techniques to enclose any Broadjam trademark, logo, or other proprietary information (including but not limited to images, text, page layout, and form) without Broadjam's express written consent  You may not use any metatags or any other "hidden text" using Broadjam's name or trademarks without Broadjam's express written consent  Any such unauthorized use shall result in the immediate and automatic termination of all permission, rights and/or licenses granted to you by Broadjam and may also result in such additional action as Broadjam deems necessary to protect and enforce its legal rights 
Hosting Subscriber expressly acknowledges that Broadjam is the sole and exclusive worldwide owner of all Broadjam Marks, as such term is defined in this Agreement 
Hosting Subscriber expressly acknowledges that this license is granted in consideration of and is conditioned upon Hosting Subscriber's full compliance with the terms and conditions of this Agreement, these additional conditions applying to Hosting Subscribers, and all Policies appearing on the Site 
This license shall terminate immediately upon expiration or termination of Hosting Subscriber's hosting subscription or Broadjam membership or if, in Broadjam's absolute discretion and without the necessity of written notice, Hosting Subscriber has failed to comply with any of the terms or conditions of this Agreement or any Policies appearing on the Site 
Hosting Subscriber agrees to display the following disclaimer prominently at the foot of the home page of Hosting Subscriber's Website: "Hosted by Broadjam  [Hosting Subscriber's Name Here] is not affiliated with Broadjam, Inc  and Broadjam bears no responsibility for the content or use of this site "
No use of Hosting Subscriber's Custom Homepage Link and no content on Hosting Subscriber's Website will dilute, tarnish, blur or otherwise diminish the value of the BROADJAM mark; and Hosting Subscriber will not use, publish or advertise the Custom Homepage Link for any purpose other than identifying the location of Hosting Subscriber's Website; and Upon Broadjam's request Hosting Subscriber will provide Broadjam with hard copy samples of any and all advertising, promotional and other tangible materials bearing the Custom Homepage Link, and will provide Broadjam with URLs to any sites or materials anywhere on the Internet pointing to, linking to or otherwise referring to the Custom Homepage Link 
The appearance, position and other aspects of the link must not be such as to damage or dilute the goodwill associated with our name and Marks or create any false appearance that we are associated with or sponsor the linking site 
Subject to applicable law, we reserve the right to revoke our consent to any link at any time in our sole discretion 
You shall retain full ownership and copyright of any and all Materials you submit to Broadjam, at all times, subject only to the rights and licenses you grant to Broadjam pursuant to this Agreement or any other applicable agreement  Without limiting any other provisions of this Agreement: you authorize and direct us to make and retain such copies of your Materials as we deem necessary in order to facilitate the storage, use and display of such Materials in accordance with your chosen account settings 
Your Materials shall not be considered assets of Broadjam in the event of a voluntary or involuntary bankruptcy 
If you believe that Materials in which you hold an ownership interest have been posted to the Site or otherwise submitted to Broadjam without your permission, you must, and hereby agree, immediately to notify Broadjam's Copyright Agent  Broadjam recommends that you register your Materials with the US Copyright Office  While Broadjam takes commercially reasonable steps to ensure that the rights of its members are not violated by Users, Broadjam has no obligation to pursue legal action against any alleged infringer of any rights in or to your Materials 
You are solely responsible at your own cost and expense for creating backup copies and replacing any Materials you post or store on the Site or otherwise provide to Broadjam 
The Site may be available via mobile devices and applications  We may provide without limitation the ability from such devices and applications to access your account, upload content to the Site and to send and receive messages, instant messages, Materials, and other types of communications that may be developed (collectively the "Mobile Services")  Your mobile carrierâs normal messaging, data and other rates and fees may apply when using the Mobile Services  In addition, downloading, installing, or using certain Mobile Services may be prohibited or restricted by your mobile carrier, and not all Mobile Services may work with all mobile carriers or devices  When available, by using any Mobile Services, you agree that we may communicate with you regarding Broadjam and the Site by multimedia messaging service, short message service, text message or other electronic means to your mobile device and that certain information about your usage of the Mobile Services may be communicated to us 
Section 512 of the Copyright Law of the United States (17 U S C  Â§512) limits liability for copyright infringement by service providers if the service provider has designated an agent for notification of claimed infringement by providing contact information to the Copyright Office and through theservice provider's website 
Broadjam has designated an agent to receive notification of alleged copyright infringement (our agent is identified below)  This Section 1 07 is without prejudice or admission as to the applicability of the Digital Millennium Copyright Act, 17 U S C , Section 512, to Broadjam 
Upon receipt of a valid claim (i e , a claim in which all required information is substantially provided) Broadjam will undertake to have the disputed Material removed from public view  We will also notify the user who posted the allegedly infringing Material that we have removed or disabled access to that Material  Broadjam has no other role to play either in prosecuting or defending claims of infringement, and cannot be held accountable in any case for damages, regardless of whether a claim of infringement is found to be true or false  Please note: If you materially misrepresent that Material infringes your copyright interests, you may be liable for damages (including court costs and attorneys fees) and could be subject to criminal prosecution for perjury 
Our designated agent will present your counter notification to the person who filed the infringement complaint  Once your counter notification has been delivered, Broadjam is allowed under the provisions of Section 512 to restore the removed Material in not less than ten or more than fourteen days, unless the complaining party serves notice of intent to obtain a court order restraining the restoration 
It is Broadjam's policy to terminate subscribers and account holders who are found to be repeat infringers 
Broadjam's designated agent is Elizabeth T Russell 
By accepting this Agreement and/or submitting Materials to Broadjam, you expressly warrant and represent the following to Broadjam and acknowledge that Broadjam is relying upon such warranties and representations: (a) That all factual assertions you have made and will make to us are true and complete; that you have reached the age of majority and are otherwise competent to enter into contracts in your jurisdiction; that you are at least 18 years of age; and that, in any event, you are deriving benefits from this Agreement and from visiting the Site 
(b) That you have obtained and hold all rights, approvals, consents, licenses and/or permissions, in proper legal form, necessary to submit Materials on the terms provided herein and to grant Broadjam the nonexclusive licenses set forth herein



ground_truth: A subset that form via kinetic rate processes from state-selected Rydberg gases.

prompt_front: Now, answer the following question based on the text below, only give me the answer and do not output any other words.

Question: What are the three synthetic types of vitamin K?

Read the following text and answer briefly.

Context 2:  283 (52): 36655–36664  doi:10 1074/jbc M802761200  PMC 2605998  PMID 18836183  ^ Viegas, C  S ; Cavaco, S ; Neves, P  L ; Ferreira, A ; João, A ; Williamson, M  K ; Price, P  A ; Cancela, M  L ; Simes, D  C  (Dec 2009)  "Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications"  American Journal of Pathology  175 (6): 2288–2298  doi:10 2353/ajpath 2009 090474  PMC 2789615  PMID 19893032  ^ Hafizi, S ; Dahlbäck, B  (Dec 2006)  "Gas6 and protein S  Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily"  The FEBS Journal  273 (23): 5231–5244  doi:10 1111/j 1742-4658 2006 05529 x  PMID 17064312  ^ Kulman, J  D ; Harris, J  E ; Xie, L ; Davie, E  W  (May 2007)  "Proline-rich Gla protein 2 is a cell-surface vitamin K-dependent protein that binds to the transcriptional coactivator Yes-associated protein"  Proceedings of the National Academy of Sciences of the United States of America  104 (21): 8767–8772  doi:10 1073/pnas 0703195104  PMC 1885577  PMID 17502622  ^ "Vitamin K"  MedlinePlus  US National Library of Medicine, National Institutes of Health  Sep 2016  Retrieved 26 May 2009  ^ Conly, J; Stein, K  (Dec 1994)  "Reduction of vitamin K2 concentrations in human liver associated with the use of broad spectrum antimicrobials"  Clinical and Investigative Medicine  17 (6): 531–539  PMID 7895417  ^ Ferland, G ; Sadowski, J  A ; O'Brien, M  E  (Apr 1993)  "Dietary induced subclinical vitamin K deficiency in normal human subjects"  Journal of Clinical Investigation  91 (4): 1761–1768  doi:10 1172/JCI116386  PMC 288156  PMID 8473516  ^ Holden, R  M ; Morton, A  R ; Garland, J  S ; Pavlov, A ; Day, A  G ; Booth, S  L  (Apr 2010)  "Vitamins K and D status in stages 3-5 chronic kidney disease"  Clinical Journal of the American Society of Nephrology  5 (4): 590–597  doi:10 2215/CJN 06420909  PMC 2849681  PMID 20167683  ^ Hodges, S  J ; Pilkington, M  J ; Shearer, M  J ; Bitensky, L ; Chayen, J (Jan 1990)  "Age-related changes in the circulating levels of congeners of vitamin K2, menaquinone-7 and menaquinone-8"  Clinical Science  78 (1): 63–66  PMID 2153497  ^ "Vitamin K"  Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (PDF)  National Academy Press  2001  p  162–196  ^ Tolerable Upper Intake Levels For Vitamins And Minerals (PDF), European Food Safety Authority, 2006 ^ a b Rhéaume-Bleue, p  42
^ "Important information to know when you are taking: Warfarin (Coumadin) and Vitamin K" (PDF)  National Institutes of Health Clinical Center  ^ "Nutrition Facts and Information for Parsley, raw"  Nutritiondata com  Retrieved 21 Apr 2013  ^ "Nutrition facts, calories in food, labels, nutritional information and analysis"  Nutritiondata com  13 Feb 2008  Retrieved 21 Apr 2013  ^ "Vitamin K"  Vivo colostate edu  2 Jul 1999  Retrieved 21 Apr 2013  ^ "Vitamin K"  Micronutrient Data Centre  ^ Ikeda, Y ; Iki, M ; Morita, A ; Kajita, E ; Kagamimori, S ; Kagawa, Y ; Yoneshima, H  (May 2006)  "Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study"  Journal of Nutrition  136 (5): 1323–1328  PMID 16614424  ^ Katsuyama, H ; Ideguchi, S ; Fukunaga, M ; Saijoh, K ; Sunami, S  (Jun 2002)  "Usual dietary intake of fermented soybeans (Natto) is associated with bone mineral density in premenopausal women"  Journal of Nutritional Science and Vitaminology  48 (3): 207–215  doi:10 3177/jnsv 48 207  PMID 12350079  ^ Sano, M ; Fujita, H ; Morita, I ; Uematsu, H ; Murota, S  (Dec 1999)  "Vitamin K2 (menatetrenone) induces iNOS in bovine vascular smooth muscle cells: no relationship between nitric oxide production and gamma-carboxylation"  Journal of Nutritional Science and Vitaminology  45 (6): 711–723  doi:10 3177/jnsv 45 711  PMID 10737225  ^ Gast, G  C ; de Roos, N  M ; Sluijs, I ; Bots, M  L ; Beulens, J  W ; Geleijnse, J  M ; Witteman, J  C ; Grobbee, D  E ; Peeters, P  H ; van der Schouw, Y  T  (Sep 2009)  "A high menaquinone intake reduces the incidence of coronary heart disease"  Nutrition, Metabolism, and Cardiovascular Diseases  19 (7): 504–510  doi:10 1016/j numecd 2008 10 004  PMID 19179058  ^ Oldenburg, J ; Bevans, C  G ; Müller, C  R ; Watzka, M  (2006)  "Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle"  Antioxidants & Redox Signaling  8 (3–4): 347–353  doi:10 1089/ars 2006 8 347  PMID 16677080  ^ Suttie, J  W  (1985)  "Vitamin K-dependent carboxylase"  Annual Review of Biochemistry  54: 459–477  doi:10 1146/annurev bi 54 070185 002331  PMID 3896125  ^ Presnell, S  R ; Stafford, D  W  (Jun 2002)  "The vitamin K-dependent carboxylase"  Thrombosis and Haemostasis  87 (6): 937–946  PMID 12083499  ^ Stafford, D  W  (Aug 2005)  "The vitamin K cycle"  Journal of Thrombosis and Haemostasis  3 (8): 1873–1878  doi:10 1111/j 1538-7836 2005 01419 x  PMID 16102054  ^ Rhéaume-Bleue, p  79 
^ Whitlon, D  S ; Sadowski, J  A ; Suttie, J  W  (Apr 1978)  "Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition"  Biochemistry  17 (8): 1371–1377  doi:10 1021/bi00601a003  PMID 646989  ^ Terlau, H ; Olivera, B  M  (Jan 2004)  "Conus venoms: a rich source of novel ion channel-targeted peptides"  Physiological Reviews  84 (1): 41–68  doi:10 1152/physrev 00020 2003  PMID 14715910  ^ Buczek, O ; Bulaj, G ; Olivera, BM (Dec 2005)  "Conotoxins and the posttranslational modification of secreted gene products"  Cellular and Molecular Life Sciences  62 (24): 3067–3079  doi:10 1007/s00018-005-5283-0  PMID 16314929  ^ "Prothrombin Time"  WebMD  ^ Dituri, F ; Buonocore, G ; Pietravalle, A ; Naddeo, F ; Cortesi, M; Pasqualetti, P; Tataranno M  L ; R , Agostino (Sep 2012)  "PIVKA-II plasma levels as markers of subclinical vitamin K deficiency in term infants"  Journal of Maternal, Fetal & Neonatal Medicine  25 (9): 1660–1663  doi:10 3109/14767058 2012 657273  PMID 22280352  ^ Thane, C  W ; Bates, C  J ; Shearer, M  J ; Unadkat, N; Harrington, D  J ; Paul, A  A ; Prentice, A ; Bolton-Smith, C  (Jun 2002)  "Plasma phylloquinone (vitamin K1) concentration and its relationship to intake in a national sample of British elderly people"  British Journal of Nutrition  87 (6): 615–622  doi:10 1079/BJNBJN2002582  PMID 12067432  ^ McKeown, N  M ; Jacques, P  F ; Gundberg, C  M ; Peterson, J  W ; Tucker, K  L ; Kiel, D  P ; Wilson, P  W ; Booth, SL (Jun 2002)  "Dietary and nondietary determinants of vitamin K biochemical measures in men and women" (PDF)  Journal of Nutrition  132 (6): 1329–1334  PMID 12042454  ^ Yamano, M ; Yamanaka, Y ; Yasunaga, K ; Uchida, K  (Sep 1989)  "Effect of vitamin K deficiency on urinary gamma-carboxyglutamic acid excretion in rats"  Nihon Ketsueki Gakkai Zasshi  52 (6): 1078–1086  PMID 2588957  ^ Matsumoto, T ; Miyakawa, T ; Yamamoto, D  (Mar 2012)  "Effects of vitamin K on the morphometric and material properties of bone in the tibiae of growing rats"  Metabolism  61 (3): 407–414  doi:10 1016/j metabol 2011 07 018  PMID 21944271  ^ Je, S -H ; Joo, N -S ; Choi, B -H ; Kim, K -M ; Kim, B -T ; Park, S -B ; Cho, D -Y ; Kim, K -N ; Lee, D -J  (Aug 2011)  "Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral density in Korean postmenopausal women over sixty-years-old"  Journal of Korean Medical Science  26 (8): 1093–1098  doi:10 3346/jkms 2011 26 8 1093  PMC 3154347  PMID 21860562  ^ Bentley, R ; Meganathan, R  (Sep 1982)  "Biosynthesis of vitamin K (menaquinone) in bacteria" (PDF)  Microbiological Reviews  46 (3): 241–280  PMC 281544  PMID 6127606  ^ Haddock, B  A ; Jones, C  W  (Mar 1977)  "Bacterial respiration" (PDF)  Bacteriological Reviews  41 (1): 47–99  PMC 413996  PMID 140652  ^ Shearer, M  J  (Jan 1995)  "Vitamin K"  Lancet  345 (8944): 229–234  doi:10 1016/S0140-6736(95)90227-9  PMID 7823718  ^ Greer, J  P ; Foerster, J ; Lukens, J  N ; Rodgers, G  M ; Paraskevas, F ; Glader, B  (eds )  Wintrobe's Clinical Hematology (11th ed )  Philadelphia, Pennsylvania: Lippincott, Williams and Wilkens  ^ a b American Academy of Pediatrics Committee on Fetus Newborn  (Jul 2003)  "Controversies concerning vitamin K and the newborn  American Academy of Pediatrics Committee on Fetus and Newborn" (PDF)  Pediatrics  112 (1 1): 191–192  doi:10 1542/peds 112 1 191  PMID 12837888  ^ Logan, S ; Gilbert, R  (1998)  "Vitamin K For Newborn Babies" (PDF)  Department of Health  Retrieved 12 Oct 2014  ^ "Postnatal care: Routine postnatal care of women and their babies [CG37]"  www nice org uk  NICE  Jul 2006  Retrieved 12 Oct 2014  ^ Parker, L ; Cole, M ; Craft, A  W ; Hey, E  N  (1998)  "Neonatal vitamin K administration and childhood cancer in the north of England: retrospective case-control study"  BMJ (Clinical Research Edition)  316 (7126): 189–193  doi:10 1136/bmj 316 7126 189  PMC 2665412  PMID 9468683  ^ McMillan, D  D  (1997)  "Routine administration of vitamin K to newborns"  Paediatric Child Health  2 (6): 429–431  ^ "Newborns get rare disorder after parents refused shots"  Having four cases since February just at Vanderbilt was a little bit concerning to me ^ Dam, C  P  H  (1935)  "The Antihaemorrhagic Vitamin of the Chick: Occurrence And Chemical Nature"  Nature  135 (3417): 652–653  doi:10 1038/135652b0  ^ Dam, C  P  H  (1941)  "The discovery of vitamin K, its biological functions and therapeutical application" (PDF)  Nobel Prize Laureate Lecture  ^ McAlister, V  C  (2006)  "Control of coagulation: a gift of Canadian agriculture" (PDF)  Clinical and Investigative Medicine  29 (6): 373–377  ^ MacCorquodale, D  W ; Binkley, S  B ; Thayer, S  A ; Doisy, E  A  (1939)  "On the constitution of Vitamin K1"  Journal of the American Chemical Society  61 (7): 1928–1929  doi:10 1021/ja01876a510  ^ Fieser, L  F  (1939)  "Synthesis of Vitamin K1"  Journal of the American Chemical Society  61 (12): 3467–3475  doi:10 1021/ja01267a072  ^ Dam, C  P  H  (12 Dec 1946)  "The discovery of vitamin K, its biological functions and therapeutical application" (PDF)  Nobel Prize lecture  ^ Warner, E  D ; Brinkhous, K  M ; Smith, H  P  (1938)  "Bleeding Tendency of Obstructive Jaundice"  Proceedings of the Society of Experimental Biology and Medicine  37 (4): 628–630  doi:10 3181/00379727-37-9668P  ^ Stenflo, J; Fernlund, P ; Egan, W ; Roepstorff, P  (Jul 1974)  "Vitamin K dependent modifications of glutamic acid residues in prothrombin"  Proceedings of the National Academy of Sciences of the United States of America  71 (7): 2730–2733  doi:10 1073/pnas 71 7 2730  PMC 388542  PMID 4528109  ^ Nelsestuen, G  L ; Zytkovicz, T  H ; Howard, J  B  (Oct 1974)  "The mode of action of vitamin K  Identification of gamma-carboxyglutamic acid as a component of prothrombin" (PDF)  Journal of Biological Chemistry  249 (19): 6347–6350  PMID 4214105  ^ Magnusson, S ; Sottrup-Jensen, L ; Petersen, T  E ; Morris, H  R ; Dell, A  (Aug 1974)  "Primary structure of the vitamin K-dependent part of prothrombin"  FEBS Letters  44 (2): 189–193  doi:10 1016/0014-5793(74)80723-4  PMID 4472513  Bibliography[edit]
Rhéaume-Bleue, Kate (2012)  Vitamin K2 and the Calcium Paradox  John Wiley & Sons, Canada  ISBN 1-118-06572-7  External links[edit]
"Vitamin K: Another Reason to Eat Your Greens"  v
TPP / ThDP (B1)
FMN, FAD (B2)
NAD+, NADH, NADP+, NADPH (B3)
Coenzyme A (B5)
PLP / P5P (B6)
THFA / H4FA, DHFA / H2FA, MTHF (B9)
AdoCbl, MeCbl (B12)
Phylloquinone (K1), Menaquinone (K2)
non-vitamins
Coenzyme B
Heme / Haem (A, B, C, O)
Molybdopterin/Molybdenum cofactor
THMPT / H4MPT
Fe2+, Fe3+
vitamins: see vitamins
Antihemorrhagics (B02)
(coagulation)
Phytomenadione (K1)
Menadione (K3)
intrinsic: IX/Nonacog alfa
VIII/Moroctocog alfa/Turoctocog alfa
extrinsic: VII/Eptacog alfa
common: X
II/Thrombin
I/Fibrinogen
XIII/Catridecacog
combinations: Prothrombin complex concentrate (II, VII, IX, X, protein C and S)
Carbazochrome
thrombopoietin receptor agonist (Romiplostim
Eltrombopag)
Tetragalacturonic acid hydroxymethylester
Epinephrine/Adrenalone
amino acids (Aminocaproic acid
Aminomethylbenzoic acid)
serpins (Aprotinin
Alfa1 antitrypsin
Camostat) 
Context 3:  (c) That no other rights, approvals, consents, licenses and/or permissions are required from any other person or entity to submit your Materials on the terms provided herein or to grant Broadjam the nonexclusive licenses set forth herein 
(d) That your Materials are original; that your Materials were either created solely by you or, by written assignment, you have acquired all worldwide intellectual property rights in and to your Materials; that if your Materials contain any "samples" or excerpts from copyrightable work the rights to which are owned in whole or in part by any person or entity other than you, that you have obtained and hold all rights, approvals, consents, licenses and/or permissions, in proper legal form, necessary to use and include such work in your Materials; and that your Materials do not otherwise infringe on the intellectual property rights of any person or entity 
(e) That neither your Materials nor any comments or reviews you post on the Site violate any common law or statutory patent, copyright, privacy, publicity, trademark or trade secret rights of any person or entity and are not libelous, defamatory, obscene or otherwise actionable at law or equity 
(f) That you have neither intentionally nor with gross negligence submitted any Materials containing or producing any virus or other harmful code or other information that could damage or otherwise interfere with our computer systems or data and/or that of our customers 
(g) You agree to sign and deliver to Broadjam any additional documents that Broadjam may request to confirm Broadjam's rights and your warranties and representations under this Agreement 
(h) You acknowledge that Broadjam is relying upon the representations, warranties and covenants you have made herein  You agree to and hereby do indemnify Broadjam, its licensees, assigns and customers against, and hold them harmless from, any loss, expense (including reasonable attorney fees and expenses), or damage occasioned by any claim, demand, suit, recovery, or settlement arising out of any breach or alleged breach of any of the representations, warranties or covenants made herein or arising out of any failure by you to fulfill any of the representations, warranties, or covenants you have made herein 
(i) All representations, warranties or covenants made herein by you shall survive termination of this Agreement 
(j) All warranties and representations made by you herein are made for the benefit of Broadjam and its sub-licensees and may be enforced separately by Broadjam and/or by any contractually designated sub-licensee of Broadjam 
In consideration of Broadjam's efforts to provide your work with public exposure, you expressly authorize Broadjam and its sub-licensees to transmit, stream, broadcast, publicly display and publicly perform in any manner, form or media whether now known or hereafter devised, worldwide, any ofthe Materials you submit to Broadjam, in accordance with the provisions of this section  Without limitation to other licenses you may be inferred to have granted in order to accomplish the foregoing, you expressly grant Broadjam and its sub-licensees the following worldwide, non-exclusive, royalty-free, sublicenseable and transferable licenses with respect to any and all Materials you submit 
Public performance license for musical works  If you are a member of any collective rights management or performing rights society ("PRS"), worldwide, licensing and compensation for public performances of your Material consisting of musical works (including qualifying performances by Broadjam and any of its sub-licensees) shall be made solely by your PRS and pursuant to your affiliation agreement with your PRS  If you are not affiliated with a PRS, or if any performance by Broadjam or any of its sub-licensees does not qualify as a performance under your affiliation agreement with your PRS: you hereby grant Broadjam and its sub-licensees a nonexclusive, royalty-free, direct license to publicly perform all musical compositions included in your Materials, worldwide, in any media formats and through any media channels now known or hereafter devised 
Public performance license for sound recordings  If you are a member of SoundExchange or any other collective rights management organization for sound recordings ("CRMO"), worldwide, licensing and compensation for public performances of your Material consisting of sound recordings (including qualifying performances by Broadjam and any of its sub-licensees) shall be made solely by your CRMO and pursuant to your affiliation agreement with your CRMO  If you are not affiliated with a CRMO, or if any performance by Broadjam or any of its sub-licensees does not qualify as a performance under your affiliation agreement with your CRMO: you hereby grant Broadjam and its sublicensees a nonexclusive, royalty-free license to publicly perform (by means of digital audio transmission and all other means) all sound recordings included in your Materials, worldwide, in any media formats and through any media channels now known or hereafter devised 
Reproduction licenses for compositions and sound recordings  Although copyright law is evolving to accommodate the digital environment, certain key issues remain unresolved  One such issue is the extent to which reproduction licenses are required for musical works and sound recordings made available on interactive streaming services  We choose to resolve the issue contractually  Accordingly, you hereby grant Broadjam and its sub-licensees nonexclusive reproduction licenses for all musical works and sound recordings included in your Materials; provided, however, that unless by separate agreement you have chosen to make your Materials available for sale through Broadjam's digital download store, such reproduction licenses are limited in scope and apply only to the extent necessary to make your Materials publicly available via Broadjam's interactive streaming services  Podcasts  From time to time Broadjam may invite you to submit your Materials for inclusion in downloadable content files known as "podcasts " Podcasts are non-live entertainment programs spotlighting the work of Broadjam members and are made available for download in unprotected media, free of charge, at the Site  Broadjam will not include your Materials in podcasts without your consent  If you choose to grant such consent, however, you also (and hereby do) grant to Broadjam and its sub-licensees all licenses reasonably required for podcasting, including nonexclusive reproduction and public performance licenses for all musical works, and nonexclusive reproduction and public performance licenses for all sound recordings, embodied in any Materials of yours selected for inclusion in Broadjam podcasts  You further release Broadjam and its sub-licensees for any and all liability arising from any alleged failure by Broadjam or any of its sub-licensees to obtain appropriate licenses for the use of any Materials of yours selected for inclusion in Broadjam podcasts 
You may at any time opt to make Materials you have uploaded to Broadjam available to other Broadjam members free of charge ("Free Songs")  The Broadjam Free Songs feature is designed to help you further circulate your music  Your songs will not be designated as Free Songs without your express consent  Broadjam makes your Free Songs available for download in unprotected media, free of charge, in the Broadjam Downloads Store ("BDS")  If you choose to designate your songs as Free Songs, you expressly authorize Broadjam and its sub-licensees to reproduce, transmit, stream, broadcast, publicly display and publicly perform in any manner, form or media whether now known or hereafter devised, such Free Songs in accordance with the provisions of this section  You may at any time choose to change the status of a song from Free" to Not Free" and vice versa in your User Profile  Broadjam shall not make any payments to you for songs downloaded by Broadjam members during the time period in which you designated your songs as Free Songs  You further release Broadjam and its sub-licensees for any and all liability arising from any unauthorized exercise of copyright rights in connection with your Materials that you have chosen to designate as Free Songs 
Broadjam shall have the right and license to use, and license others to use, your Materials for the purpose of promoting our products and services, and to use all names, likenesses, biographical materials, logos, trademarks or trade names of you and all individuals performing on or otherwise represented in your Materials without any payment to you or any other Persons, entities, groups or associations, in accordance with the provisions of this section  All rights and licenses you grant to Broadjam pursuant to this section shall terminate, with respect to specific Materials, when, in accordance with this Agreement, you exercise your right to request removal of such Materials 
You represent and warrant that you have exclusive authority to grant all licenses that are granted to Broadjam and its sub-licensees in this Agreement  You understand that Broadjam is relying on this representation and warranty  You agree to and hereby do indemnify Broadjam, its licensees, assigns and customers against, and hold them harmless from, any loss, expense (including reasonable attorney fees and expenses), or damage occasioned by any claim, demand, suit, recovery, or settlement arising out of any breach or alleged breach of any of the representations, warranties or covenants made herein or arising out of any failure by you to fulfill any of the representations, warranties, or covenants you have made herein 
Sub-licensees designated by Broadjam to transmit, stream, broadcast, publicly display and/or publicly perform your Materials may pay a fee to Broadjam for facilitating access to such Materials and you hereby agree that Broadjam shall be entitled to collect and retain 100% of all such facilitation fees without any obligation to you 
(a) You acknowledge that the Site may from time to time encounter technical or other problems and may not necessarily continue uninterrupted or without technical or other errors and that Broadjam shall not be responsible to you or others for any such interruptions, errors or problems or for discontinuance of any Broadjam Service  Broadjam provides no assurances whatever that any of your Materials will ever be accessed or used by Broadjam, its visitors, Subscribers or sub-licensees nor, if so accessed or used, that your Materials will continue to be available for any particular length or period of time 
(b) A possibility exists that the Site or any Service could include inaccuracies or errors, or information or materials that violate this Agreement  Additionally, a possibility exists that unauthorized alterations could be made by third parties to the Site or any Service  Although we attempt to ensure the integrity of the Site and every Service, we make no guarantees as to their completeness or correctness  In the event that a situation arises in which the Site's or any Services' completeness or correctness is in question, you agree to contact us including, if possible, a description of the material to be checked and the location (URL) where such material can be found, as well as information sufficient to enable us to contact you  We will make best efforts to address your concerns as soon as reasonably practicable  For copyright infringement claims, see Broadjam's Digital Millennium Copyright (DMCA) Policy, set forth in Section 1 07 of this Agreement 
(c) The Site and any Service may be discontinued at any time, with or without reason or cause 
(d) Broadjam disclaims any and all responsibility for the deletion, failure to store, misdelivery or untimely delivery of any information or Material  Broadjam disclaims any and all responsibility for harm resulting from downloading or accessing any information or Material on the Internet or through the Site 
(e) THIS SITE, INCLUDING ANY CONTENT OR INFORMATION CONTAINED WITHIN IT OR ANY SITE-RELATED SERVICE, IS PROVIDED "AS IS," WITH NO REPRESENTATIONS OR WARRANTIES OF ANY KIND, EITHER EXPRESSED OR IMPLIED  TO THE FULLEST EXTENT PERMISSIBLE PURSUANT TO APPLICABLE LAW, BROADJAM AND ITS AFFILIATES, LICENSORS, SUPPLIERS, ADVERTISERS, SPONSORS AND AGENTS DISCLAIM ALL WARRANTIES, EXPRESS OR IMPLIED, INCLUDING, WITHOUT LIMITATION, IMPLIED WARRANTIES OF TITLE, NON-INFRINGEMENT, ACCURACY, MERCHANTABILITY, AND FITNESS FOR A PARTICULAR PURPOSE, AND ANY WARRANTIES THAT MAY ARISE FROM COURSE OF DEALING, COURSE OF PERFORMANCE OR USAGE OF TRADE  BROADJAM AND ITS AFFILIATES, LICENSORS, SUPPLIERS, ADVERTISERS, SPONSORS AND AGENTS DISCLAIM ANY AND ALL WARRANTIES REGARDING THE SECURITY, RELIABILITY, TIMELINESS, AND PERFORMANCE OF ANY BROADJAM SERVICE  BROADJAM AND ITS AFFILIATES, LICENSORS, SUPPLIERS, ADVERTISERS, SPONSORS AND AGENTS DISCLAIM ANY AND ALL WARRANTIES FOR ANY INFORMATION OR ADVICE OBTAINED THROUGH THE SITE  NO OPINION, ADVICE OR STATEMENT OF BROADJAM OR ITS AFFILIATES, LICENSORS, SUPPLIERS, ADVERTISERS, SPONSORS, AGENTS, MEMBERS OR VISITORS, WHETHER MADE ON THE SITE OR OTHERWISE, SHALL CREATE ANY WARRANTY  BROADJAM AND ITS AFFILIATES, LICENSORS, SUPPLIERS, ADVERTISERS, SPONSORS AND AGENTS DISCLAIM ANY AND ALL WARRANTIES FOR SERVICES OR GOODS RECEIVED THROUGH OR ADVERTISED ON THE SITE OR RECEIVED THROUGH ANY LINKS APPEARING ANYWHERE ON THE SITE, AS WELL AS FOR ANY INFORMATION OR ADVICE RECEIVED THROUGH ANY LINKS PROVIDED ANYWHERE ON THE SITE 
(f) BROADJAM AND ITS AFFILIATES, LICENSORS, SUPPLIERS, ADVERTISERS, SPONSORS AND AGENTS DO NOT WARRANT THAT YOUR USE OF THE SITE WILL BE UNINTERRUPTED, ERROR-FREE OR SECURE, THAT DEFECTS WILL BE CORRECTED, OR THAT THE SITE OR THE SERVER(S) ON WHICH THE SITE IS HOSTED ARE FREE OF VIRUSES OR OTHER HARMFUL COMPONENTS  YOU ACKNOWLEDGE THAT YOU ARE RESPONSIBLE FOR OBTAINING AND MAINTAINING ALL TELEPHONE, COMPUTER HARDWARE AND OTHER EQUIPMENT NEEDED TO ACCESS AND USE THE SITE, AND ALL CHARGES RELATED THERETO  YOU ASSUME ALL RESPONSIBILITY AND RISK FOR YOUR USE OF THE SITE AND ANY SERVICE AND YOUR RELIANCE THEREON  YOU UNDERSTAND AND AGREE THAT YOU DOWNLOAD OR OTHERWISE OBTAIN MATERIAL, INFORMATION OR DATA THROUGH THE USE OF THE SITE AT YOUR OWN DISCRETION AND RISK AND THAT YOU WILL BE SOLELY RESPONSIBLE FOR ANY DAMAGES TO YOUR COMPUTER SYSTEM OR LOSS OF DATA THAT RESULTS FROM THE DOWNLOAD OF SUCH MATERIAL, INFORMATION OR DATA 
(g) SOME STATES OR OTHER JURISDICTIONS DO NOT ALLOW THE EXCLUSION OF IMPLIED WARRANTIES, SO THE ABOVE EXCLUSIONS MAY NOT APPLY TO YOU  YOU MAY ALSO HAVE OTHER RIGHTS THAT VARY FROM STATE TO STATE AND JURISDICTION TO JURISDICTION  PROVIDED, HOWEVER, THAT TO THE EXTENT PERMITTED BY APPLICABLE LAW YOU HEREBY WAIVE THE PROVISIONS OF ANY STATE LAW LIMITING OR PROHIBITING SUCH EXCLUSIONS 
(a) NEITHER BROADJAM NOR ANY OF OUR AFFILIATES, LICENSORS, SUPPLIERS, ADVERTISERS OR SPONSORS, NOR OUR OR THEIR DIRECTORS, OFFICERS, EMPLOYEES, CONSULTANTS, AGENTS OR OTHER REPRESENTATIVES (TOGETHER, FOR PURPOSES OF THIS SECTION, "BROADJAM"), ARE RESPONSIBLE OR LIABLE FOR ANY INDIRECT, INCIDENTAL, CONSEQUENTIAL, SPECIAL, EXEMPLARY, PUNITIVE OR OTHER DAMAGES (INCLUDING, WITHOUT LIMITATION, DAMAGES FOR LOSS OF BUSINESS, LOSS OF DATA OR LOST PROFITS), UNDER ANY CONTRACT, NEGLIGENCE, WARRANTY, STRICT LIABILITY OR OTHER THEORY ARISING OUT OF OR RELATING IN ANY WAY TO USE OR MISUSE OF OR RELIANCE ON THE SITE OR ANY BROADJAM SERVICE OR ANY LINKED SITE, EVEN IF BROADJAM HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES, AND IN NO EVENT SHALL BROADJAM'S TOTAL CUMULATIVE LIABILITY UNDER THIS AGREEMENT EXCEED THE TOTAL AMOUNT PAID BY YOU, IF ANY, TO ACCESS THE SITE  SUCH LIMITATION OF LIABILITY SHALL APPLY WHETHER THE DAMAGES ARISE FROM USE OR MISUSE OF AND/OR RELIANCE ON THE SITE OR ANY BROADJAM SERVICE, FROM INABILITY TO USE THE SITE OR ANY BROADJAM SERVICE, OR FROM THE INTERRUPTION, SUSPENSION, OR TERMINATION OF THE SITE OR ANY BROADJAM SERVICE (INCLUDING SUCH DAMAGES INCURRED BY THIRD PARTIES)  THIS LIMITATION SHALL ALSO APPLY WITH RESPECT TO DAMAGES INCURRED BY REASON OF OTHER SERVICES OR GOODS RECEIVED THROUGH OR ADVERTISED ON THE SITE OR RECEIVED THROUGH ANY LINKS PROVIDED AT, IN OR THROUGH THE SITE, AS WELL AS BY REASON OF ANY INFORMATION OR ADVICE RECEIVED THROUGH OR ADVERTISED ON THE SITE OR RECEIVED THROUGH ANY LINKS PROVIDED ON THE SITE OR ANY BROADJAM SERVICE  THIS LIMITATION SHALL ALSO APPLY, WITHOUT LIMITATION, TO THE COSTS OF PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES, LOST PROFITS, AND LOST DATA  SUCH LIMITATION SHALL FURTHER APPLY WITH RESPECT TO THE PERFORMANCE OR NONPERFORMANCE OF THE SITE OR ANY BROADJAM SERVICE OR ANY INFORMATION OR MERCHANDISE THAT APPEARS ON, OR IS LINKED OR RELATED IN ANY WAY TO, THE SITE OR ANY BROADJAM SERVICE  SUCH LIMITATION SHALL APPLY NOTWITHSTANDING ANY FAILURE OF ESSENTIAL PURPOSE OF ANY LIMITED REMEDY AND TO THE FULLEST EXTENT PERMITTED BY LAW 
(b) SOME STATES OR OTHER JURISDICTIONS DO NOT ALLOW THE EXCLUSION OR LIMITATION OF LIABILITY FOR INCIDENTAL OR CONSEQUENTIAL DAMAGES, SO THE ABOVE LIMITATIONS AND EXCLUSIONS MAY NOT APPLY TO YOU  PROVIDED, HOWEVER, THAT TO THE EXTENT PERMITTED BY APPLICABLE LAW YOU HEREBY WAIVE THE PROVISIONS OF ANY STATE LAW LIMITING OR PROHIBITING SUCH EXCLUSIONS OR LIMITATIONS 
(c) WITHOUT LIMITING THE FOREGOING, UNDER NO CIRCUMSTANCES SHALL BROADJAM BE HELD LIABLE FOR ANY DELAY OR FAILURE IN PERFORMANCE RESULTING DIRECTLY OR INDIRECTLY FROM ACTS OF NATURE, FORCES, OR CAUSES BEYOND ITS REASONABLE CONTROL, INCLUDING, WITHOUT LIMITATION, INTERNET FAILURES, COMPUTER EQUIPMENT FAILURES, TELECOMMUNICATION EQUIPMENT FAILURES, OTHER EQUIPMENT FAILURES, ELECTRICAL POWER FAILURES, STRIKES, LABOR DISPUTES, RIOTS, INSURRECTIONS, CIVIL DISTURBANCES, SHORTAGES OF LABOR OR MATERIALS, FIRES, FLOODS, STORMS, EXPLOSIONS, ACTS OF GOD, EPIDEMIC, WAR, GOVERNMENTAL ACTIONS, ORDERS OF DOMESTIC OR FOREIGN COURTS OR TRIBUNALS, NON-PERFORMANCE OF THIRD PARTIES, OR LOSS OF OR FLUCTUATIONS IN HEAT, LIGHT, OR AIR CONDITIONING 
(a) All content included on this Site, including but not limited to text, graphics, logos, button icons, images, data compilations, code and source code, multimedia content, including but not limited to images, illustrations, audio and video clips, html and other mark up languages, and all scripts within the Site or associated therewith, are the property of Broadjam or its content suppliers and is protected by United States and international copyright laws with All Rights Reserved  The compilation of all content on this Site is the exclusive property of Broadjam and is protected by United States and international copyright laws with All Rights Reserved  All software used on this site is the property of Broadjam or its software suppliers and is protected by United States and international copyright laws with All Rights Reserved 
(b) "Broadjam," "Broadjam Top 10," "Metajam", "broadjam com", "Musicians of Broadjam," Mini MoB, PRIMO MoB and other trademarks, service marks, logos, labels, product names and service names appearing on the Site (collectively, the "Marks") are owned or licensed by Broadjam  Marks not owned by Broadjam or its subsidiaries are the property of their respective owners, who may or may not be affiliated with, connected to, or sponsored by Broadjam 
(c) You agree not to copy, display or otherwise use any Marks without Broadjam's prior written permission  The Marks may never be used in any manner likely to cause confusion, disparage or dilute the Marks and/or in connection with any product or service that is not authorized or sponsored by Broadjam 
(a) We make no representation that products or services available on or through the Site or any Service are appropriate or available for use in other locations other than the United States  Those who choose to access the Site or any Service from other locations do so on their own initiative and at their own risk, and are responsible for compliance with local laws, if and to the extent local laws are applicable  By accessing the Site or using any Services you are consenting to have your personal data transferred to and processed in the United States 
(b) Products, including software, made available through the Site or any Service are further subject to United States export controls  You agree to comply with all applicable laws regarding the transmission of technical data exported from the United States or the country in which you reside  No such products may be downloaded or otherwise exported or re-exported (i) into (or to a national or resident of) any country to which the U S  has embargoed goods; or (ii) to anyone on the U S  Treasury Department's list of Specially Designated Nationals or the U S  Commerce Department's Table of Deny Orders  By downloading any product available through the Site or any Service, you represent and warrant that you are not located in, under the control of, or a national or resident of any such country or on any such list  We reserve the right to limit the availability of the Site and/or any Service or product described thereon to any person, geographic area or jurisdiction, at any time and in our sole discretion, and to limit the quantities of any such Service or product that we provide 
Broadjam may also provide access to certain services (including, without limitation and by way of example only: advertising, promotion, and submission processing services for contests, radio play, publishing, placement and licensing opportunities) that are supplied by others ("Third Party Services")  YOU EXPRESSLY ACKNOWLEDGE THAT BROADJAM BEARS NO RESPONSIBILITY FOR THIRD PARTY SERVICES; BROADJAM EXPRESSLY DISCLAIMS ANY/ALL LIABILITY FOR THIRD PARTY SERVICES; AND BROADJAM MAKES NO WARRANTY, REPRESENTATION OR GUARANTEE TO YOU REGARDING ANY ASPECT OF THIRD PARTY SERVICES  ANY CLAIM YOU MAY HAVE REGARDING ANY THIRD PARTY SERVICE MUST BE PURSUED DIRECTLY AND EXCLUSIVELY WITH THE INDIVIDUAL OR GROUP, WHETHER OR NOT ORGANIZED AS A LEGAL ENTITY (THE "THIRD PARTY PROVIDER"), THAT SUPPLIED THE THIRD PARTY SERVICE  BROADJAM IS NOT A PARTY TO ANY RULES, CONTRACTS OR OTHER AGREEMENTS BETWEEN YOU AND ANY THIRD PARTY PROVIDER, AND YOU EXPRESSLY AGREE NOT TO JOIN OR ATTEMPT TO JOIN BROADJAM AS A PARTY IN ANY DISPUTE BETWEEN YOU AND ANY THIRD PARTY PROVIDER 
Upon receipt of your written request, Broadjam will remove any of your Materials from the Site within a reasonable period of time  Broadjam's licenses to use such Materials will continue for any copies of such Materials that may have been disseminated in any format or media prior to the actual removal of such Materials from the Site 
You agree that, at any time, Broadjam may revise, change or modify any terms and conditions of this Agreement and/or any aspect of any Service, without notice to you  You can review the most current version of this Agreement at any time at: http://www broadjam com  When using any Service, you and Broadjam shall also be subject to any guidelines, Policies or rules applicable to such Service which may be posted on the Site from time to time  All such guidelines, Policies or rules are hereby incorporated by reference into this Agreement and you agree to their terms  Any such revisions, changes or modifications shall be binding and effective immediately upon posting of same to the Site 
(a) Your rights under this Agreement are not assignable and any attempt by your creditors to obtain an interest in your rights under this Agreement, whether by attachment, levy, garnishment or otherwise, renders this Agreement voidable at Broadjam's option 
(b) This Agreement is binding onthe Parties and their respective heirs, legatees, executors, successors and assigns  Except for Policies and other agreements incorporated by reference herein, this Agreement is the entire agreement between the Parties and supersedes all prior written or oral agreements between the Parties relating to the subject matter hereof  If any portion of this Agreement is found to be void or unenforceable, the remaining portion shall be enforceable with the invalid portion removed, giving all reasonable construction to permit the essential purposes of the Agreement to be achieved  The Parties' various rights and remedies hereunder shall be construed to be cumulative 
(c) This Agreement shall be deemed to have been made in the State of Wisconsin, and it shall be governed by the substantive laws of the State of Wisconsin without regard to any applicable conflict of laws provisions  The Parties submit to jurisdiction in the state and federal courts sitting in Dane County, Wisconsin, and you hereby waive any jurisdictional, venue or inconvenient forum objections  Provided, however, that if we are sued or joined in an action in any other court or forum in respect of any matter which may give rise to a claim by us hereunder, you consent to the jurisdiction of such court or forum over any such claim  Nothing in this paragraph or Agreement constitutes our consent to the assertion of personal jurisdiction over Broadjam otherwise than in Wisconsin 
(d) Nothing contained in this Agreement shall be construed to require the commission of any act contrary to law  Nothing in this Agreement shall be construed or deemed to create any partnership, agency, joint venture, employment or franchise relationship between the Parties 
(e) Each Party hereto agrees to execute all further and additional documents as may be necessary or desirable to effectuate and carry out the provisions of this Agreement 
(f) Captions and headings used in this Agreement are for purposes of convenience only and shall not be deemed to limit, affect the scope, meaning or intent of this Agreement, nor shall they otherwise be given any legal effect 
(g) No breach of this Agreement by Broadjam shall be deemed material unless the Party alleging such breach shall have given Broadjam written notice of such breach, and Broadjam shall fail to cure such breach within thirty (30) days after its receipt of such notice 
(h) All notices required to be sent to Broadjam under this Agreement shall be in writing and shall be sent by certified mail, return receipt requested, postage paid, or by overnight delivery service, to Broadjam Inc , 211 S  Paterson St  Ste  360 Madison, WI 53703 Attention: Legal (or such other address or addresses as may be designated by Broadjam herein) 
(i) All duties, liabilities, obligations, warranties, representations, covenants, authorizations, agreements and restrictions undertaken by and/or imposed upon you in connection with this Agreement shall be deemed to apply jointly and severally to all members collectively and each member individually of any group at any time comprising the Artist whose recordings or other Materials you post, upload or otherwise make available to Broadjam  You affirmatively represent that you have the authority to bind all such individuals to the terms and conditions of this Agreement 
(j) You agree that regardless of any statute or law to the contrary, any claim or cause of action against Broadjam, arising out of or related to use of the Site or any Service, must be filed within one (1) year after such claim or cause of action arose or be forever barred 
Sacramento, California 95834, or by telephone at (800) 952-5210 
available by contacting Broadjam at the above address, Attention: Customer Service 
(m) This Agreement has no intended third party beneficiaries 
(a) This Article II applies to any Person (hereinafter a "Subscriber") who subscribes to any member subscription service offered by Broadjam, including but not limited to, by way of example, Mini MoB or PRIMO MoB (hereinafter a "Subscription Service")



ground_truth: Vitamins K3, K4, and K5.

prompt_front: Now, answer the following question based on the text below, only give me the answer and do not output any other words.

Question: What are the restrictions on the use of Broadjam's servers?

Read the following text and answer briefly.

Context 3:  For purposes of this Agreement all Subscribers are also Users as defined herein 
(b) You agree to provide true, accurate, current and complete information about yourself as prompted by the subscription registration processes (such information being your "Account Information")  You further agree that, in providing such Account Information, you will not knowingly omit or misrepresent any material facts or information and that you will promptly enter corrected or updated Account Information, or otherwise advise us promptly in writing of any such changes or updates  You further consent and authorize us to verify your Account Information as required for your use of and access to the Site and any Service, as applicable 
(c) As a Subscriber, you will receive a unique username and password in connection with your account (collectively referred to herein as your "Username")  You agree that you will not allow another person to use your Username to access and use the Site or any Service under any circumstances  You are solely and entirely responsible for maintaining the confidentiality of your Username and for any charges, damages, liabilities or losses incurred or suffered as a result of your failure to do so  Broadjam is not liable for any harm caused by or related to the theft of your Username, your disclosure of your Username, or your authorization to allow another person to access and use the Site or any Service using your Username  Furthermore, you are solely and entirely responsible for any and all activities that occur under your account, including, but not limited to, any charges incurred relating to the Site or any Service  You agree to immediately notify us of any unauthorized use of your account or any other breach of security known to you  You acknowledge that the complete privacy of your data transmitted while using the Site or any Service cannot be guaranteed 
The term of any Subscription Service shall commence when the Subscriber initiates payment for such Subscription Service or, if the Subscription Service is complimentary, when the Subscriber registers for such Subscription Service  All Subscription Services will extend for an initial period of oneyear (the "Term") and, unless terminated as provided herein, shall renew automatically for successive one-year periods  During the Term, the Subscriber shall be afforded the full use and benefit of the applicable Subscription Service as described on the Site (the "Service Benefits"), which Service Benefits may be revised by Broadjam from time to time without notice to the Subscriber  Due to technical considerations, certain Service Benefits may not be available to the Subscriber immediately upon commencement of the Term, but shall be provided to the Subscriber as soon as commercially reasonable  Please direct any questions about Subscription Services or Service Benefits to Broadjam by email at: customerservice@broadjam com or by US mail at: Broadjam Inc , 100 S  Baldwin St  Ste  #204, Madison, WI 53703, Attn: Customer Service 
(b) maintain and update such information as needed to keep it current, complete and accurate 
Subscriber acknowledges that Broadjam relies and will rely upon the accuracy of such information as supplied by Subscriber 
(a) Termination by Subscriber  Subscriber may terminate any Subscription Service at any time by providing Broadjam with written notice pursuant to this Agreement  Written notice will be followed by a confirmation request from Broadjam Customer Service  Confirmation is required to implement termination  Such termination will be effective after the paid period  In the case of termination by the Subscriber, the period that is already paid for will not be reimbursed  The Subscription Service will remain active until the end of the paid period 
(a) As consideration for a Subscription Service, Subscriber agrees to pay Broadjam all applicable subscription fees as posted on the Site at the time Subscriber applies for the Subscription Service  All subscription fees are due immediately pursuant to the payment option Subscriber chooses, and are non-refundable except as otherwise provided herein  Broadjam may exercise all available remedies to collect fees due and owing for any Subscription Service 
(b) Broadjam may, at its sole discretion and for any Subscription Service, offer Subscriber the option to pay Subscriber's annual subscription fee in monthly installments (a "Payment Plan")  If Subscriber elects a Payment Plan, Subscriber agrees to provide Broadjam with a valid credit card number, which Broadjam will charge on a monthly basis for twelve (12) consecutive months, in an amount each month equal to 1/12th of the subscription fee for the Subscription Service, plus a finance charge, until the Subscription Service is terminated pursuant to this Agreement  By providing credit card billing information, Subscriber shall be authorizing Broadjam to charge that credit card until termination of the Subscription Service  Broadjam shall have the right immediately to discontinue Subscriber's Service Benefits if Broadjam does not receive payment when due 
In order to change any of Subscriber's account information, Subscriber must use the User Name and the Password that Subscriber selected when Subscriber registered as a Broadjam User  In no event will Broadjam be liable for any unauthorized use or misuse of Subscriber's User Name and Password 
Subscriber agrees that Subscriber's failure to abide by any provision of this Agreement or any Broadjam operating rule or policy, Subscriber's willful provision of inaccurate or unreliable information as part of the application process, Subscriber's failure to update Subscriber's information to keep it current, complete or accurate, and/or Subscriber's failure to respond to inquiries from Broadjam concerning the accuracy of Subscriber's account information shall be considered a material breach of this Agreement  If within ten (10) calendar days after Broadjam provides notice (in any form and via any method of delivery) to Subscriber of such material breach, Subscriber fails to provide evidence, reasonably satisfactory to Broadjam, that Subscriber has not breached its obligations under this Agreement, Broadjam may terminate all Services, Subscription and otherwise, without further notice to Subscriber 
This Article III applies to any Person (hereinafter a "Hosting Subscriber") who subscribes to any web hosting subscription service offered by Broadjam, including but not limited to, by way of example, PRIMO MoB (hereinafter a "Hosting Service")  For purposes of this Agreement all Hosting Subscribers are also Subscribers and Users as defined herein 
Hosting Subscriber's Website will not be used in connection with any illegal activity 
(b) Hosting Subscriber is responsible for ensuring that there is no excessive overloading on Broadjam's DNS or servers  Broadjam prohibits the use of software or scripts run on its servers that cause the server to load beyond a reasonable level, as determined by Broadjam  Hosting Subscriber agrees that Broadjam reserves the right to remove Hosting Subscriber's Website temporarily or permanently from its hosting servers if Hosting Subscriber's Website threatens the stability of Broadjam's network 
(c) Hosting Subscriber may not use Broadjam's servers or Hosting Subscriber's Website as a source, intermediary, reply to address, or destination address for mail bombs, Internet packet flooding, packet corruption, denial of service, or any other abusive activities  Server hacking or other perpetration of security breaches is strictly prohibited and Broadjam reserves the right to remove websites that contain information about hacking or links to such information  Use of Hosting Subscriber's Website as an anonymous gateway is prohibited 
engage in any other activity deemed by Broadjam to be in conflict with the spirit or intent of this Agreement or any Broadjam policy 
Subject to the terms and conditions of this Agreement, Broadjam shall attempt to provide Hosting Services for twenty-four (24) hours a day, seven (7) days a week throughout the term of Hosting Subscriber's subscription  Hosting Subscriber agrees that from time to time the Hosting Service may be inaccessible or inoperable for any reason, including, without limitation, equipment malfunctions; periodic maintenance procedures or repairs which Broadjam may undertake from time to time; or causes beyond the control of Broadjam or which are not reasonably foreseeable by Broadjam, including, without limitation, interruption or failure of telecommunication or digital transmission links, hostile network attacks, network congestion or other failures  Hosting Subscriber agrees that Broadjam makes no representation or assurance that Hosting Services will be available on a continuous or uninterrupted basis 
At all times, Hosting Subscriber shall bear full risk of loss and damage to Hosting Subscriber's Website and all of Hosting Subscriber's Website content  Hosting Subscriber is solely responsible for maintaining the confidentiality of Hosting Subscriber's Password and account information  Hosting Subscriber agrees that Hosting Subscriber is solely responsible for all acts, omissions and use under and charges incurred with Hosting Subscriber's account or password or any of Hosting Subscriber's Website content  Hosting Subscriber shall be solely responsible for undertaking measures to: (i) prevent any loss or damage to Hosting Subscriber's Website content; (ii) maintain independent archival and backup copies of Hosting Subscriber's Website content; (iii) ensure the security, confidentiality and integrity of all of Hosting Subscriber's Website content transmitted through or stored on Broadjam servers; and (iv) ensure the confidentiality of Hosting Subscriber's password  Broadjam's servers and Hosting Services are not an archive and Broadjam shall have no liability to Hosting Subscriber or any other person for loss, damage or destruction of any of Hosting Subscriber's content  If Hosting Subscriber's password is lost, stolen or otherwise compromised, Hosting Subscriber shall promptly notify Broadjam, whereupon Broadjam shall suspend access to Hosting Subscriber's Website by use of such password and issue a replacement password to Hosting Subscriber or Hosting Subscriber's authorized representative  Broadjam will not be liable for any loss that Hosting Subscriber may incur as a result of someone else using Hosting Subscriber's password or account, either with or without Hosting Subscriber's knowledge  However, Hosting Subscriber could be held liable for losses incurred by Broadjam or another party due to someone else using Hosting Subscriber's account or password 
(a) Broadjam does not tolerate the transmission of spam  We monitor all traffic to and from our Web servers for indications of spamming and maintain a spam abuse compliant center to register allegations of spam abuse  Customers suspected to be using Broadjam products and services for the purposeof sending spam are fully investigated  Once Broadjam determines there is a problem with spam, Broadjam will take the appropriate action to resolve the situation  Our spam abuse compliant center can be reached by email at hosting@broadjam com 
(c) Broadjam will not allow its servers or services to be used for the purposes of spam as described above  In order to use our products and services, Hosting Subscriber shall abide by all applicable laws and regulations, including but not limited to the Can-Spam Act of 2003 and the Telephone Consumer Protection Act, as well as Broadjam's no-spam policies  Commercial advertising and/or bulk emails or faxes may only be sent to recipients who have already "opted-in" to receive messages from the sender specifically  They must include a legitimate return address and reply-to address, the sender's physical address, and an opt-out method in the footer of the email or fax  Upon request by Broadjam, conclusive proof of optin may be required for an email address or fax number 
(d) If Broadjam determines that Hosting Services are being used in association with spam, Broadjam will re-direct, suspend, or cancel such Hosting Service for a period of no less than 2 days  The Hosting Subscriber will be required to respond by email to Broadjam stating that Hosting Subscriber will cease to send spam and/or have spam sent on their behalf  Broadjam will require a non-refundable reactivation fee to be paid before Hosting Subscriber's Website, email boxes and/or other Hosting Services are reactivated  In the event Broadjam determines the abuse has not stopped after services have been restored the first time, Broadjam may terminate all Services associated with the Hosting Subscriber 
This Article IV applies to all Users 
Fees and prices appearing on the Site are based on United States dollars  Payments for any Service or purchase made on or through the Site shall be made to Broadjam in United States dollars, except as provided in Section 4 05 herein 
You agree to pay for all fees and charges incurred under your Broadjam account or Username  If you have configured the account associated with your Username (your "Account") to pay for Services or purchases with a credit or debit card or similar form of payment (a "Card" payment method), you authorize any and all charges and fees incurred under your Account to be billed from time to time to your Card account  Regardless of the method of payment, it is your sole responsibility to advise Broadjam of any billing problems or discrepancies within thirty (30) days after such discrepancies or problems become known to you  Your Card issuer agreement governs the use of your designated Card account in connection with any fee, purchase or Service; you must refer exclusively to such issuer agreement, and not this Agreement, to determine your rights and liabilities as a Cardholder  If you submit a payment that results in Broadjam being charged non-sufficient funds, chargeback fees, or other similar fees, you agree to reimburse all such fees 
Monthly Billing Subscriptions  No refunds will be issued for monthly billing subscriptions  If monthly billing is selected and is not cancelled by the end of the monthly period (30 days from the sign up date), your Card will be billed at the beginning of the next 30 day period  In order to avoid additional charges to your Card, you must contact Broadjam Customer Service by email (customerservice@broadjam com) at least 5 days before your next billing period, to cancel your Subscription Service  Your email should include the following: registered name on the account, registered email address on the account, and the service to be cancelled  Notice will be followed by a confirmation request from Broadjam Customer Service  Confirmation is required to implement cancellation 
(a) Merchants who elect to be paid in Purchase Credits ("PCs") for sales at Broadjam, Buyers who choose to purchase PCs and Users who otherwise obtain PCs (collectively, "Holders" of PCs) shall hold PCs subject to the provisions of this Section 4 05 as well as all rules and policies posted on the Site relating to PCs 
(b) PCS ARE NONRETURNABLE AND NONREFUNDABLE 
(c) PCs do not have an expiration date  However, if there exists rules defined by the laws of your state that require Broadjam to terminate your right to use PCs if you have not used them within a specified number of years  Under those laws, Broadjam will attempt to contact you before terminating your right to use PCs 
(e) Holders shall have no right to demand cash or any other thing of value in exchange for PCs, except as provided in Section 4 05 (d) 
(f) Interest shall not accrue on PCs 
(a) Buyers who choose to purchase the Primo MoB membership which includes complimentary Weekly Submission Credits ("WSCs") for the term of the membership purchased for use towards Music Licensing Opportunities services and shall hold WSCs subject to the provisions of this Section 4 06 as well as all rules and policies posted on the Site relating to WSCs 
(b) WSCs ARE NONRETURNABLE AND NONREFUNDABLE 
(c) One WSC is available for use each week for the duration of the membership purchased  One WSC is available each week starting Sunday at 12:00 am midnight CST  If unused, each WSC will expire on the following Sunday at 11:59 pm CST 
ii  wholly controlled by Broadjam 
(f) Holders shall have no right to demand cash or any other thing of value in exchange for WSCs, except as provided in Section 4 06 (e) 
(g) Interest shall not accrue on WSCs 
(a) Buyers who choose to purchase the Film/TV membership which includes complimentary Monthly Submission Credits ("MSCs") for the term of the membership purchased for use towards Music Licensing Opportunities services and shall hold MSCs subject to the provisions of this Section 4 07 as well as all rules and policies posted on the Site relating to MSCs 
(b) MSCs ARE NONRETURNABLE AND NONREFUNDABLE 
(c) One MSC is available for use each month for the duration of the membership purchased  One MSC is available each month starting the first day of the month at 12:00 am midnight CST  If unused, each WSC will expire on the last day of the month at 11:59 pm CST 
(f) Holders shall have no right to demand cash or any other thing of value in exchange for MSCs, except as provided in Section 4 07 (e) 
(g) Interest shall not accrue on MSCs 
Checks issued by Broadjam to any User, for any purpose, are VOID after 180 days from the date of issue  Users who fail to cash Broadjam-issued checks within such 180-day period will be charged a $2 00 fee for re-depositing funds from the stale check to the User's account  Users requesting replacement checks will be charged an additional $5 00 fee for issuance of the replacement check 
The following shall apply if you purchase Broadjam's Deliveries services 
Refunds will not be issued for Broadjam Deliveries services  If you experience a technical problem related to Broadjam Deliveries services, Broadjam will take steps in accordance with Section 1 10 to ensure your transaction is completed successfully  Broadjam may at its sole discretion convey complimentary services to you in the event of a verified technical problem 
The following shall apply if you purchase Broadjam's Music Software services 
Refunds will not be issued for Music Software services  If you experience a technical problem related to Broadjam Music Software services, Broadjam will take steps in accordance with Section 1 10 to ensure your transaction is completed successfully  Broadjam may at its sole discretion convey complimentary services to you in the event of a verified technical problem 



ground_truth: No excessive overloading and no use for illegal activity.