prompt_front: Now, answer the following question based on the text below, only give me the answer and do not output any other words.

Question: How are thalassemias classified?

Read the following text and answer briefly.

Context 1: Thalassaemia minor | definition of Thalassaemia minor by Medical dictionary
Thalassaemia minor | definition of Thalassaemia minor by Medical dictionary
https://medical-dictionary thefreedictionary com/Thalassaemia+minor
(redirected from Thalassaemia minor)
Related to Thalassaemia minor: thalassaemia major
Thalassemia describes a group of inherited disorders characterized by reduced or absent amounts of hemoglobin, the oxygen-carrying protein inside the red blood cells  There are two basic groups of thalassemia disorders: alpha thalassemia and beta thalassemia  These conditions cause varying degrees of anemia, which can range from insignificant to life threatening 
All types of thalassemias are considered quantitative diseases of hemoglobin, because the quantity of hemoglobin produced is reduced or absent  Usual adult hemoglobin is made up of three components: alpha globin, beta globin, and heme  Thalassemias are classified according to the globin that is affected, hence the names alpha and beta thalassemia  Although both classes of thalassemia affect the same protein, the alpha and beta thalassemias are distinct diseases that affect the body in different ways 
Beta thalassemia may be the most best-known type of thalassemia and is also called Cooley's anemia  It is caused by a change in the gene for the beta globin component of hemoglobin  Beta thalassemia causes variable anemia that can range from moderate to severe, depending in part on the exact genetic change underlying the disease  Beta thalassemia can be classified based on clinical symptoms  Beta thalassemia major usually causes severe anemia that can occur within months after birth  If left untreated, severe anemia can result in insufficient growth and development, as well as other common physical complications that can lead to a dramatically decreased life-expectancy  Fortunately, in developed countries beta thalassemia is usually identified by screening in the newborn period, before symptoms have developed  Children who are identified early can be started on ongoing blood transfusion therapy as needed  Although transfusion therapy prevents many of the complications of severe anemia, the body is unable to eliminate the excess iron contained in the transfused blood  Over time, the excess iron deposits in tissues and organs, resulting in damage and organ failure  Another medication must be administered to help the body eliminate the excess iron and prevent iron-over-load complications  Beta thalassemia intermedia describes the disease in individuals who have moderate anemia that only requires blood transfusions intermittently, if at all 
Alpha thalassemia is the result of changes in the genes for the alpha globin component of hemoglobin  There are two main types of alpha thalassemia disease: hemoglobin H disease and alpha thalassemia major  The two diseases are quite different from beta thalassemia as well as from one another  Individuals with hemoglobin H disease can experience events of hemolytic anemia—anemia caused by the rapid breakdown of the red blood cells  These events are thought to be triggered by various environmental causes, such as infection and/or exposure to certain chemicals  Hemoglobin H disease is in most cases milder than beta thalassemia  It does not generally require transfusion therapy  Alpha thalassemia major is a very serious disease that results in severe anemia that begins even before birth  Most affected babies do not survive to be born or die shortly after birth 
The thalassemias are among the most common genetic diseases worldwide  Both alpha and beta thalassemia have been described in individuals of almost every ancestry, but the conditions are more common among certain ethnic groups  Unaffected carriers of all types of thalassemia traits do not experience health problems  In fact, the thalassemia trait is protective against malaria, a disease caused by blood-borne parasites transmitted through mosquito bites  According to a widely accepted theory, most genetic changes—mutations—that cause thalassemia occurred multiple generations ago  Coincidentally, these mutations increased the likelihood that carriers would survive malaria infection  Survivors passed the mutation onto their offspring, and the trait became established throughout areas where malaria is common  As populations migrated, so did the thalassemia traits 
Beta thalassemia trait is seen most commonly in people with the following ancestry: Mediterranean (including North African, and particularly Italian and Greek), Middle Eastern, Indian, African, Chinese, and Southeast Asian (including Vietnamese, Laotian, Thai, Singaporean, Filipino, Cambodian, Malaysian, Burmese, and Indonesian)  Alpha-thalassemia trait is seen with increased frequency in the same ethnic groups  However, there are different types of alpha thalassemia traits within these populations  The frequency of hemoglobin H disease and alpha thalassemia major depends on the type of alpha thalassemia trait  The populations in which alpha thalassemia diseases are most common include Southeast Asians and Chinese (particularly Southern Chinese) 
It is difficult to obtain accurate prevalence figures for various types of thalassemia within different populations  This difficulty arises due to testing limitations in determining exact genetic diagnoses, as well as the fact that many studies have focused on small, biased hospital populations 
Two studies reflect prevalence figures that can be helpful counseling families and determining who to screen for beta thalassemia  Between the years of 1990 and 1996, the State of California screened more than 3 1 million infants born in the state for beta thalassemia  Approximately 1 in 114,000 infants had beta thalassemia major, with prevalence rates being highest among Asian Indians (about one in 4,000), Southeast Asians (about one in 10,000), and Middle Easterners (about one in 7,000)  Another type of beta thalassemia disease, E/beta thalassemia, was represented in approximately one in 110,000 births, all of which occurred in families of Southeast Asian ancestry  Among Southeast Asians, the prevalence of E/beta thalassemia was approximately one in 2,600 births  This is in keeping with the observation that hemoglobin E trait carrier rates are relatively high within the Southeast Asian population: 16% in a study of 768 immigrants to California, and up to 25% in some specific Southeast Asian populations such as Cambodians  While these California studies address some of the limitations of earlier population studies, the pattern observed in California is expected to be different in other areas of the United States and the world  For example, Italians are underrepresented in this population when compared to the population of the East Coast of the United States 
Determining prevalence figures for alpha thalassemia is even more difficult due to increased limitations in diagnostic testing  All types of alpha thalassemia disease are most common among people of Southeast Asian and Chinese descent, for reasons that become clearer with an understanding of the underlying genetics of alpha thalassemia  One study of 500 pregnant women in Northern Thailand estimated a frequency of one in 500 pregnancies affected by alpha thalassemia major, for example  Prevalence of alpha thalassemia disease is significantly lower in the United States primarily because of immigration patterns; although at least one state, California, has observed growing hemoglobin H disease incidence rates that are high enough to justify universal newborn screening for the condition 
Humans normally make several types of the oxygen-carrying protein hemoglobin  An individual's stage in development determines whether he or she makes primarily embryonic, fetal, or adult hemoglobins  All types of hemoglobin are made of three components: heme, alpha (or alpha-like) globin, and beta (or beta-like) globin  All types of thalassemia are caused by changes in either the alpha- or beta-globin gene  These changes cause little or no globin to be produced  The thalassemias are, therefore, considered quantitative hemoglobin diseases  All types of thalassemias are recessively inherited, meaning that a genetic change must be inherited from both the mother and the father  The severity of the disease is influenced by the exact thalassemia mutations inherited, as well as other genetic and environmental factors  There are rare exceptions, notably with beta thalassemia, where globin gene mutations exhibit a dominant pattern of inheritance in which only one gene needs to be altered in order to see disease expression  Scientists continue to study the causes  For instance, a new mutation for alpha-thalassemia was discovered for the first time among Iranian patients in 2004 
BETA-THALASSEMIA  Most individuals have two normal copies of the beta globin gene, which is located on chromosome 11 and makes the beta globin component of normal adult hemoglobin, hemoglobin A  There are approximately 100 genetic mutations that have been described that cause beta thalassemia, designated as either beta0 or beta + mutations  No beta globin is produced with a beta0 mutation, and only a small fraction of the normal amount of beta globin is produced with a beta + mutation 
When an individual has one normal beta globin gene and one with a beta thalassemia mutation, he or she is said to carry the beta thalassemia trait  Beta thalassemia trait, like other hemoglobin traits, is protective against malaria infection  Trait status is generally thought not to cause health problems, although some women with beta thalassemia trait may have an increased tendency toward anemia during pregnancy 
When two members of a couple carry the beta thalassemia trait, there is a 25% chance that each of their children will inherit beta thalassemia disease by inheriting two beta thalassemia mutations, one from each parent  The clinical severity of the beta thalassemia disease—whether an individual has beta thalassemia intermedia or beta thalassemia major—will depend largely on whether the mutations inherited are beta0 thalassemia or beta + thalassemia mutations  Two beta0 mutations generally lead to beta thalassemia major, and two beta+ thalassemia mutations generally lead to beta thalassemia intermedia  Inheritance of one beta0 and one beta + thalassemia mutation tends to be less predictable 
Although relatively uncommon, there are other thalassemia-like mutations that can affect the beta globin gene  Hemoglobin E is the result of a substitution of a single nucleotide  This change results in a structurally altered hemoglobin that is produced in decreased amounts  Therefore, hemoglobin E is unique in that it is both a quantitative (i e  thalassemia-like) and qualitative trait  When co-inherited with a beta thalassemia trait, it causes a disease that is almost indistinguishable from beta thalassemia disease  Large deletions around and including the beta globin gene can lead to delta/beta thalassemia or hereditary persistence of fetal hemoglobin (HPFH)  Interestingly, delta/beta thalassemia trait behaves very similarly to beta thalassemia trait in its clinical manifestations  However, HPFH trait does not tend to cause hemoglobin disease when co-inherited with a second thalassemia or other beta globin mutation 
ALPHA-THALASSEMIA  Most individuals have four normal copies of the alpha globin gene, two copies on each chromosome 16  These genes make the alpha globin component of normal adult hemoglobin, which is called hemoglobin A  Alpha globin is also a component of fetal hemoglobin and the other major adult hemoglobin called hemoglobin A2  Mutations of the alpha globin genes are usually deletions of the gene, resulting in absent production of alpha globin  Since there are four genes (instead of the usual two) to consider when looking at alpha globin gene inheritance, there are several alpha globin types that are possible 
Absence of one alpha globin gene leads to a condition known as silent alpha thalassemia trait  This condition causes no health problems and can be detected only by special genetic testing  Alpha thalassemia trait occurs when two alpha globin genes are missing  This can occur in two ways  The genes may be deleted from the same chromosome, causing the 'cis' type of alpha thalassemia trait  Alternately, they may be deleted from different chromosomes, causing the 'trans' type of alpha thalassemia trait  In both instances, there are no associated health problems, although the trait status may be detected by more routine blood screening 
Hemoglobin H disease results from the deletion of three alpha globin genes, such that there is only one functioning gene  Typically, this can occur when one parent carries the silent alpha thalassemia trait, and the other parent carries the 'cis' type of the alpha thalassemia trait  In this situation, there is a 25% chance for hemoglobin H disease in each of such a couple's children 
Hemoglobin H disease-like symptoms can also be a part of a unique condition called alpha thalassemia mental retardation syndrome  Alpha thalassemia mental retardation syndrome can be caused by a deletion of a significant amount of chromosome 16, affecting the alpha globin genes  This is usually not inherited, but rather occurs sporadically in the affected individual  Affected individuals have mild hemoglobin H disease, mild-to-moderate mental retardation, and characteristic facial features  This syndrome can also occur as a sex-linked form in which a mutation is inherited in a particular gene on the X-chromosome  This gene influences alpha globin production, as well as various other developmental processes  Individuals affected with this form of the syndrome tend to have more severe mental retardation, delayed development, nearly absent speech, characteristic facial features, and genital-urinary abnormalities  The remaining discussion will focus only on aspects of hemoglobin H disease 
Alpha thalassemia major results from the deletion of all four alpha globin genes, such that there are no functioning alpha globin genes  This can occur when both parents carry the 'cis' type of the alpha thalassemia trait  In this situation, there is a 25% chance for alpha thalassemia major in each of such a couple's children 
Beta thalassemia major is characterized by severe anemia that can begin months after birth  In the United States and other developed countries beta thalassemia is identified and treated early and effectively  Therefore, the following discussion of symptoms applies primarily to affected individuals in the past and unfortunately in some underdeveloped countries now  If untreated, beta thalassemia major can lead to severe lethargy, paleness, and delays in growth and development  The body attempts to compensate by producing more blood, which is made inside the bones in the marrow  However, this is ineffective without the needed genetic instructions to make enough functioning hemoglobin  Instead, obvious bone expansion and changes occur that cause characteristic facial and other changes in appearance, as well as increased risk of fractures  Severe anemia taxes other organs in the body—such as the heart, spleen, and liver—which must work harder than usual  This can lead to heart failure, as well as enlargement and other problems of the liver and spleen  When untreated, beta thalassemia major generally results in childhood death, usually due to heart failure  In 2004, the first known heart attack associated with beta thalassemia major was reported  Fortunately, in developed countries diagnosis is usually made early, often before symptoms have begun  This allows for treatment with blood transfusion therapy, which can prevent most of the complications of the severe anemia caused by beta thalassemia major  Individuals with beta thalassemia intermedia have a more moderate anemia that may only require treatment with transfusion intermittently, such as when infections occur and stress the body  As a person with beta thalassemia intermedia gets older, however, the need for blood transfusions may increase to the point that they are required on a regular basis  When this occurs their disease becomes more similar to beta thalassemia major  Other genetic and environmental factors can influence the course of the disease as well  For example, co-inheritance of one or two alpha thalassemia mutations can tend to ameliorate some of the symptoms of beta thalassemia disease, which result in part from an imbalance in the amount of alpha- and beta-globin present in the red blood cells 
Hemoglobin h disease
Absence of three alpha globin genes causes an imbalance of alpha and beta globin proteins in the red blood cells  The excess beta globin proteins tend to come together to form hemoglobin H, which is unable to release oxygen to the tissues  In addition, hemoglobin H tends to precipitate out in the cells, causing damage to the red blood cell membrane  When affected individuals are exposed to certain drugs and chemicals known to make the membrane more fragile, the cells are thought to become vulnerable to breakdown in large numbers, a complication called hemolytic anemia  Fever and infection are also considered to be triggers of hemolytic anemia in hemoglobin H disease  This can result in fatigue, paleness, and a yellow discoloration of the skin and whites of eyes called jaundice  Usually, the anemia is mild enough not to require treatment  Severe anemia events may require blood transfusion, however, and are usually accompanied by such other symptoms as dark feces or urine and abdominal or back pain  These events are uncommon in hemoglobin H disease, although they occur more frequently in a more serious type of hemoglobin H disease called hemoglobin H/Constant Spring disease  Individuals effected with this type of hemoglobin H disease are also more likely to have enlargement of and other problems with the spleen 
Alpha thalassemia major
Because alpha globin is a necessary component of all major hemoglobins and some minor hemoglobins, absence of all functioning alpha globin genes leads to serious medical consequences that begin even before birth  Affected fetuses develop severe anemia as early as the first trimester of pregnancy  The placenta, heart, liver, spleen, and adrenal glands may all become enlarged  Fluid can begin collecting throughout the body as early as the start of the second trimester, causing damage to developing tissues and organs  Growth retardation is also common  Affected fetuses usually miscarry or die shortly after birth  In addition, women carrying affected fetuses are at increased risk of developing complications of pregnancy and delivery  Up to 80% of such women develop toxemia, a disturbance of metabolism that can potentially lead to convulsions and coma  Other maternal complications include premature delivery and increased rates of delivery by cesarean section, as well as hemorrhage after delivery 
Thalassemia may be suspected if an individual shows signs that are suggestive of the disease  In all cases, however, laboratory diagnosis is essential to confirm the exact diagnosis and to allow for the provision of accurate genetic counseling about recurrence risks and testing options for parents and affected individuals  Screening is likewise recommended to determine trait status for individuals of high-risk ethnic groups 
The following tests are used to screen for thalassemia disease and/or trait:
hemoglobin electrophoresis with quantitative hemoglobin A2 and hemoglobin F
free erythrocyte-protoporphyrin (or ferritin or other studies of serum iron levels)
A complete blood count will identify low levels of hemoglobin, small red blood cells, and other red blood cell abnormalities that are characteristic of a thalassemia diagnosis  Since thalassemia trait can sometimes be difficult to distinguish from iron deficiency, tests to evaluate iron levels are important  A hemoglobin electrophoresis is a test that can help identify the types and quantities of hemoglobin made by an individual  This test uses an electric field applied across a slab of gel-like material  Hemoglobins migrate through this gel at various rates and to specific locations, depending on their size, shape, and electrical charge  Isoelectric focusing and high-performance liquid chromatography (HPLC) use similar principles to separate hemoglobins and can be used instead of or in various combinations with hemoglobin electrophoresis to determine the types and quantities of hemoglobin present  Hemoglobin electrophoresis results are usually within the normal range for all types of alpha thalassemia  However, hemoglobin A2 levels and sometimes hemoglobin F levels are elevated when beta thalassemia disease or trait is present  Hemoglobin electrophoresis can also detect structurally abnormal hemoglobins that may be co-inherited with a thalassemia trait to cause thalassemia disease (i e , hemoglobin E) or other types of hemoglobin disease (i e , sickle hemoglobin)  Sometimes DNA testing is needed in addition to the above screening tests  This can be performed to help confirm the diagnosis and establish the exact genetic type of thalassemia 
Diagnosis of thalassemia can occur under various circumstances and at various ages  Several states offer thalassemia screening as part of the usual battery of blood tests done for newborns  This allows for early identification and treatment  Thalassemia can be identified before birth through the use of prenatal diagnosis  Chorionic villus sampling (CVS) can be offered as early as 10 weeks of pregnancy and involves removing a sample of the placenta made by the baby and testing the cells  CVS carries a risk of causing a miscarriage that is between 0 5%-1%  Amniocentesis is generally offered between 15 and 22 weeks of pregnancy, but can sometimes be offered earlier  Two to three tablespoons of the fluid surrounding the baby is removed  This fluid contains fetal cells that can be tested  The risk of miscarriage associated with amniocentesis ranges from 0 33-0 5%  Pregnant woman and couples may choose prenatal testing in order to prepare for the birth of a baby that may have thalassemia  Alternately, knowing the diagnosis during pregnancy allows for the option of pregnancy termination  Preimplantation genetic diagnosis (PGD) is a relatively new technique that involves in-vitro fertilization followed by genetic testing of one cell from each developing embryo  Only the embryos unaffected by sickle cell disease are transferred back into the uterus  PGD is currently available on a research basis only and is relatively expensive 
Individuals with beta thalassemia major receive regular blood transfusions, usually on a monthly basis  This helps prevent severe anemia and allows for more normal growth and development  Transfusion therapy does have limitations, however  Individuals can develop reactions to certain proteins in the blood—called a transfusion reaction  This can make locating appropriately matched donor blood more difficult  Although blood supplies in the United States are very safe, particularly relative to the past and to other areas of the world, there remains an increased risk of exposure to such blood-borne infections as hepatitis  Additionally, the body is not able to get rid of the excess iron that accompanies each transfusion  An additional medication called desferoxamine is administered, usually five nights per week over a period of several hours, using an automatic pump that can be used during sleep or taken anywhere the person goes  This medication is able to bind to the excess iron, which can then be eliminated through urine  If desferoxamine is not used regularly or is unavailable, iron overload can develop and cause tissue damage and organ damage and failure  The heart, liver, and endocrine organs are particularly vulnerable  Desferoxamine itself may rarely produce allergic or toxic side effects, including hearing damage  Signs of desferoxamine toxicity are screened for and generally develop in individuals who overuse the medication when body iron levels are sufficiently low  Overall, however, transfusion and desferoxamine therapy have increased the life expectancy of individuals with the most severe types of beta thalassemia major to the 4th or 5th decade  This can be expected to improve with time and increased developments in treatment, as well as for those with more mild forms of the disease 
New treatments offer additional options for some individuals with beta thalassemia major  There are various medications that target the production of red blood cells (i e  erythropoeitin) or fetal hemoglobin (i e  hydroxyurea and butyrate)  Their effectiveness in ameliorating the severity of beta thalassemia is currently being investigated  Another promising new treatment is bone marrow transplantation, in which the bone marrow of an affected individual is replaced with the bone marrow of an unaffected donor  If successful, this treatment can provide a cure  However, there is an approximately 10-15% chance the procedure could be unsuccessful (i e  the thalassemia returns); result in complications (i e  graft-versus-host disease); or result in death  The risk for specific individuals depends on current health status, age, and other factors  Because of the risks involved and the fact that beta thalassemia is a treatable condition, transplant physicians require a brother or sister donor who has an identically matched tissue type, called HLA type  HLA type refers to the unique set of proteins present on each individual's cells, which allows the immune system to recognize "self" from "foreign " HLA type is genetically determined, so there is a 25% chance for two siblings to be a match  Transplant physicians and researchers are also investigating ways to improve the safety and effectiveness of bone marrow transplantation  Using newborn sibling umbilical cord blood—the blood from the placenta that is otherwise discarded after birth but contains cells that can go on to make bone marrow—seems to provide a safer and perhaps more effective source of donor cells  Donors and recipients may not have to be perfect HLA matches for a successful transplant using cord blood cells  Trials are also underway to determine the effectiveness of "partial transplants," in which a safer transplant procedure is used to replace only a percentage of the affected individual's bone marrow  Other possible treatments on the horizon may include gene therapy techniques aimed at increasing the amount of normal hemoglobin the body is able to make 
Hemoglobin H disease is a relatively mild form of thalassemia that may go unrecognized  It is not generally considered a condition that will reduce one's life expectancy  Education is an important part of managing the health of an individual with hemoglobin H disease  It is important to be able to recognize the signs of severe anemia that require medical attention  It is also important to be aware of the medications, chemicals, and other exposures to avoid due to the theoretical risk they pose of causing a severe anemia event  When severe anemia occurs, it is treated with blood transfusion therapy  For individuals with hemoglobin H disease, this is rarely required  For those with the hemoglobin H/Constant Spring form of the disease, the need for transfusions may be intermittent or ongoing, perhaps on a monthly basis and requiring desferoxamine treatment  Individuals with this more severe form of the disease may also have an increased chance of requiring removal of an enlarged and/or overactive spleen 
Anemia — A blood condition in which the level of hemoglobin or the number of red blood cells falls below normal values  Common symptoms include paleness, fatigue, and shortness of breath 
Bilirubin — A yellow pigment that is the end result of hemoglobin breakdown  This pigment is metabolized in the liver and excreted from the body through the bile  Bloodstream levels are normally low; however, extensive red cell destruction leads to excessive bilirubin formation and jaundice 
Bone marrow — A spongy tissue located in the hollow centers of certain bones, such as the skull and hip bones  Bone marrow is the site of blood cell generation 
Bone marrow transplantation — A medical procedure used to treat some diseases that arise from defective blood cell formation in the bone marrow  Healthy bone marrow is extracted from a donor to replace the marrow in an ailing individual  Proteins on the surface of bone marrow cells must be identical or very closely matched between a donor and the recipient 
Desferoxamine — The primary drug used in iron chelation therapy  It aids in counteracting the life-threatening buildup of iron in the body associated with long-term blood transfusions 
Globin — One of the component protein molecules found in hemoglobin  Normal adult hemoglobin has a pair each of alpha-globin and beta-globin molecules 
Heme — The iron-containing molecule in hemoglobin that serves as the site for oxygen binding 
Hemoglobin — Protein-iron compound in the blood that carries oxygen to the cells and carries carbon dioxide away from the cells 
Hemoglobin A — Normal adult hemoglobin that contains a heme molecule, two alpha-globin molecules, and two beta-globin molecules 
Hemoglobin electrophoresis — A laboratory test that separates molecules based on their size, shape, or electrical charge 
Hepatomegaly — An abnormally large liver 
HLA type — Refers to the unique set of proteins called human leukocyte antigens  These proteins are present on each individual's cell and allow the immune system to recognize 'self' from 'foreign'  HLA type is particularly important in organ and tissue transplantation 
Hydroxyurea — A drug that has been shown to induce production of fetal hemoglobin  Fetal hemoglobin has a pair of gamma-globin molecules in place of the typical beta-globins of adult hemoglobin  Higher-than-normal levels of fetal hemoglobin can ameliorate some of the symptoms of thalassemia 
Iron overload — A side effect of frequent blood transfusions in which the body accumulates abnormally high levels of iron  Iron deposits can form in organs, particularly the heart, and cause life-threatening damage 
Jaundice — Yellowing of the skin or eyes due to excess of bilirubin in the blood 
Mutation — A permanent change in the genetic material that may alter a trait or characteristic of an individual, or manifest as disease, and can be transmitted to offspring 
Placenta — The organ responsible for oxygen and nutrition exchange between a pregnant mother and her developing baby 
Red blood cell — Hemoglobin-containing blood cells that transport oxygen from the lungs to tissues  In the tissues, the red blood cells exchange their oxygen for carbon dioxide, which is brought back to the lungs to be exhaled 
Screening — Process through which carriers of a trait may be identified within a population 
Splenomegaly — Enlargement of the spleen 
Because alpha thalassemia major is most often a condition that is fatal in the prenatal or newborn period, treatment has previously been focused on identifying affected pregnancies in order to provide appropriate management to reduce potential maternal complications  Pregnancy termination provides one form of management  Increased prenatal surveillance and early treatment of maternal complications is an approach that is appropriate for mothers who wish to continue their pregnancy with the knowledge that the baby will most likely not survive  In recent years, there have been a handful of infants with this condition who have survived long-term  Most of these infants received experimental treatment including transfusions before birth, early delivery, and even bone marrow transplantation before birth, although the latter procedure has not yet been successful  For those infants that survive to delivery, there seems to be an increased risk of developmental problems and physical effects, particularly heart and genital malformations  Otherwise, their medical outlook is similar to a child with beta thalassemia major, with the important exception that ongoing, life-long blood transfusions begin right at birth 
As discussed above, the prognosis for individuals with the most serious types of thalassemia has improved drastically in the last several years following recent medical advances in transfusion, chemo-, and transplantation therapy  Advances continue and promise to improve the life expectancy and quality of life further for affected individuals 
"First Known Heart Attack Associated With Beta-thalassemia Major Reported " Heart Disease Weekly February 22, 2004: 10 
"Novel Alpha-thalassemia Mutations Identified " Hematology Week January 26, 2004: 19 
Children's Blood Foundation  333 East 38th St , Room 830, New York, NY 10016-2745  (212) 297-4336  cfg@nyh med cornell edu 
Cooley's Anemia Foundation, Inc  129-09 26th Ave  #203, Flushing, NY 11354  (800) 522-7222 or (718) 321-2873  http://www thalassemia org 
March of Dimes Birth Defects Foundation  1275 Mamaroneck Ave , White Plains, NY 10605  (888) 663-4637  resourcecenter@modimes org  http://www modimes org 
National Heart, Lung, and Blood Institute  PO Box 30105, Bethseda, MD 20824-0105  (301) 592-8573  nhlbiinfo@rover nhlbi nih gov  http://www nhlbi nih gov 
National Organization for Rare Disorders (NORD)  PO Box 8923, New Fairfield, CT 06812-8923  (203) 746-6518 or (800) 999-6673  Fax: (203) 746-6481  http://www rarediseases org 
Bojanowski J  "Alpha Thalassemia Major: The Possibility of Long-Term Survival " Pamphlet from the Northern California Comprehensive Thalassemia Center  (1999) 
Children's Hospital Oakland, Northern California Comprehensive Thalassemia Center website  http://www thalassemia com 
Cooley's Anemia Foundation, Inc  website  http://www thalassemia org/gohome html 
Joint Center for Sickle Cell and Thalassemic Disorders website  http://cancer mgh harvard edu/medOnc/sickle htm 
[thal″ah-se´me-ah]
a heterogeneous group of hereditary hemolytic anemias marked by a decreased rate of synthesis of one or more hemoglobin polypeptide chains, classified according to the chain involved (α, β, δ); the two major categories are α- and β-thalassemia 
α-thalassemia (alpha-thalassemia) that caused by diminished synthesis of alpha chains of hemoglobin  The homozygous form is incompatible with life, the stillborn infant displaying severe hydrops fetalis  The heterozygous form may be asymptomatic or marked by mild anemia 
β-thalassemia (beta-thalassemia) that caused by diminished synthesis of beta chains of hemoglobin  The homozygous form is called t  major and the heterozygous form is called t  minor 
thalassemia ma´jor the homozygous form of β-thalassemia, in which hemoglobin A is completely absent; it appears in the newborn period and is marked by hemolytic, hypochromic, microcytic anemia; hepatosplenomegaly; skeletal deformation; mongoloid facies; and cardiac enlargement 
thalassemia mi´nor the heterozygous form of β-thalassemia; it is usually asymptomatic, but there may be mild anemia 
sickle cell–thalassemia a hereditary anemia involving simultaneous heterozygosity for hemoglobin S and thalassemia 
thal·as·se·mi·a
, thalassanemia (thal'ă-sē'mē-ă, thă-las-ă-nē'mē-ă),
Any of a group of inherited disorders of hemoglobin metabolism in which there is impaired synthesis of one or more of the polypeptide chains of globin; several genetic types exist, and the corresponding clinical picture may vary from barely detectable hematologic abnormality to severe and fatal anemia 
[G  thalassa, the sea, + haima, blood]
/thal·as·se·mia/ (thal″ah-se´me-ah) a heterogeneous group of hereditary hemolytic anemias marked by a decreased rate of synthesis of one or more hemoglobin polypeptide chains, classified according to the chain involved (α, β, δ); the two major categories are α- and β-thalassemia 
α-thalassemia that caused by diminished synthesis of alpha chains of hemoglobin  The homozygous form is incompatible with life, the stillborn infant displaying severe hydrops fetalis  The heterozygous form may be asymptomatic or marked by mild anemia 
β-thalassemia that caused by diminished synthesis of beta chains of hemoglobin  The homozygous form is called t  major and the heterozygous form is called t  minor 
thalassemia ma´jor the homozygous form of &#x03B2;, in which hemoglobin A is completely absent; it appears in the newborn period and is marked by hemolytic, hypochromic, microcytic anemia, hepatosplenomegaly, skeletal deformation, mongoloid facies, and cardiac enlargement 
thalassemia mi´nor the heterozygous form of &#x03B2;, usually asymptomatic, although there is sometimes mild anemia 
(thăl′ə-sē′mē-ə)
An inherited form of anemia occurring chiefly among people of Mediterranean descent, caused by faulty synthesis of part of the hemoglobin molecule  Also called Mediterranean anemia 
thal′as·se′mic adj 
[thal′əsē′mē·ə]
Etymology: Gk, thalassa, sea, a + haima, without blood
production and hemolytic anemia characterized by microcytic, hypochromic red blood cells  Thalassemia is caused by inherited deficiency of alpha- or beta-globin synthesis  See also hemochromatosis, hemosiderosis 
Beta thalassemia, clinical thalassemia, Cooley's anemia, Mediterranean anemia, thalassemia major Hematology A group of genetic diseases by underproduction of hemoglobin due to mutations in the beta globin gene, which is more common in Mediterraneans Heredity Parents are carriers–heterozygotes; one in 4 children is homozygous for the mutation and thus has full-blown disease Clinical See Anemia  Cf Sickle cell anemia 
α-thalassemia
Hemoglobin Barts Hematology An inherited condition caused by a defect in the synthesis of the Hb α chain; Hb Barts hemoglobinopathy is characterized by the presence of 4 gamma chains; it is more common in southeast Asians; the most severe form of alpha thalassemia causes stillbirth due to hydrops fetalis Heredity Parents are carriers–heterozygotes; one in 4 children is homozygous for the mutation and thus has full-blown disease Clinical Pallor, fatiguability, FTT, fever, infections, diarrhea Management Transfusions
Thalassemia major Hematology A hemoglobinopathy caused by a defect in the synthesis of Hb β chain Clinical Pallor, fatigability, FTT, fever due to infections, diarrhea, bone deformities, hepatosplenomegaly Management Transfusions, but iron overload can damage the heart, liver, and endocrine systems, ergo iron chelation–early use of deferiprone, deferoxamine ↓ transfusion-related iron overload and may protect against DM, cardiac disease, early death
δ-thalassemia
Hematology A condition characterized by a defect of Hb A2–α2δ2; because Hb A2 comprises only 3% of the circulating Hb, even its complete absence; δ-thalassemia has little clinical or hematologic impact
γ-thalassemia
Hematology A condition characterized by a defect of gamma–γ Hb chains found in Hb F–α2γ2; because Hb F is present primarily in the fetus and newborns, it is rarely seen outside of the neonatal period, but may cause transient neonatal hemolytic anemia 
, thalassanemia (thal'ă-sē'mē-ă, -ă-să-nē'mē-ă)
Any of a group of inherited disorders of hemoglobin metabolism in which there is impaired synthesis of one or more of the polypeptide chains of globin; several genetic types exist, and the corresponding clinical picture may vary from barely detectable hematologic abnormality to severe and fatal anemia  People of Mediterranean, extraction are more often affected than others by this type of anemia 
Synonym(s): thalassaemia, thalassanaemia 
Any of a group of inherited disorders of hemoglobin metabolism with impaired synthesis of one or more polypeptide chains of globin; several genetic types exist 
<a href="https://medical-dictionary thefreedictionary com/Thalassaemia+minor">thalassemia</a>
Barts hemoglobin
beta hemoglobinopathy
beta-delta thalassemia
beta-thalassaemia
Bite Cell
black gallstone
I know of a couple, totally unrelated and unbeknownst to them, who are silent carriers of Thalassaemia minor 
Pakistan: Genetic factor: All in the genes
But, unfortunately, when one person with thalassaemia minor carrier happens to marry another with the same diagnosis, there is a strong possibility that their child would be thalassaemia major, as happened in the case of Taneja 
' My life depends upon a monthly blood transfusion '
0] thalassaemia demonstrates variable severity, ranging from a condition similar to [beta] thalassaemia minor to something approaching thalassaemia major 
A retrospective review of homozygous haemoglobin E patients
Thal, Alan P 
thalame
thalamencephalic
thalamencephalon
thalamic
thalamic fasciculus
thalamic nucleus
thalamic pain syndrome
thalamic peduncle
thalamic radiation
thalamo-
thalamocoele
thalamocortical
thalamocortical fibers
thalamogeniculate artery
thalamolenticular
thalamoperforating artery
thalamostriate radiation
thalamotuberal artery
Thalassaemia minor
thalassaemiaor Cooley's disease
thalassemic facies
thalasso-
Thalassobacter
Thalassobacter utilis
thalassoplankton
thalassoposia
thalidomide neuropathy
Thalidomider
thallium poisoning
Thalarctos
THALAS
Thalasaemia
Thalassaemia Association of Malaysia
thalassaemia major
Thalassaemias
thalassaemic
thalassanaemia
Thalassemia Action Group
Thalassemia Clinical Research Network
thalassemia syndrome
Context 2: The future of mobile CPUs, part 1: Today’s fork in the road | Ars Technica
2013 may be a big year for the evolution of smartphones and tablets 
Mobile computing's rise from niche market to the mainstream is among the most significant technological trends in our lifetimes  And to a large extent, it's been driven by the bounty of Moore’s Law—the rule that transistor density doubles every 24 months  Initially, most mobile devices relied on highly specialized hardware to meet stringent power and size budgets  But with so many transistors available, devices inevitably grew general-purpose capabilities  Most likely, that wasn't even the real motivation  The initial desire was probably to reduce costs by creating a more flexible software ecosystem with better re-use and faster time to market  As such, the first smartphones were very much a novelty, and it took many years before the world realized the potential of such devices  Apple played a major role by creating innovative smartphones that consumers craved and quickly adopted 
To some extent, this is where we still stand today  Smartphones are still (relatively) expensive and primarily interesting to the developed world  But over the next 10 years, this too will change  As Moore’s Law rolls on, the cost of a low-end smartphone will decline  At some point, the incremental cost will be quite minimal and many feature phones of today will be supplanted by smartphones  A $650 unsubsidized phone is well beyond the reach of most of the world compared to a $20 feature phone, but a $30 to $40 smartphone would naturally be very popular 
In this grand progression, 2013 will certainly be a significant milestone for mobile devices, smartphones and beyond  It's likely to be the first year in which tablets out-ship notebooks in the US  And in the coming years, this will lead to a confluence of high-end tablets and ultra-mobile notebooks as the world figures out how these devices co-exist, blend, hybridize, and/or merge 
Against this backdrop, in this two-part series, we'll explore the major trends and evolution for mobile SoCs  More importantly, we'll look to where the major vendors are likely going in the next several years 
Tablet and phone divergence
While phones and tablets are mobile devices that often share a great deal of software, it's becoming increasingly clear the two are very different products  These two markets have started to diverge and will continue doing so over time 
From a technical perspective, smartphones are far more compact and power constrained  Smartphone SoCs are limited to around 1W, both by batteries and by thermal dissipation  The raison d’etre of a smartphone is connectivity, so a cellular modem is an absolute necessity  For the cost sensitive-models that make up the vast majority of the market, the modem is integrated into the SoC itself  High-end designs favor discrete modems with a greater power budget instead  The main smartphone OSes today are iOS and Android, though Windows is beginning to make an appearance (perhaps with Linux or BlackBerry on the horizon)  Just as importantly, phone vendors like HTC must pass government certification and win the approval of carriers  There is very much a walled-garden aspect, where carriers control which devices can be attached to their networks, and in some cases devices can only be sold through a certain carrier  The business model places consumers quite far removed from the actual hardware 
In contrast, tablets are far more akin to the PC both technically and economically  The power budget for tablet SoCs is much greater, up to 4W for a passively cooled device and as high as 7-8W for systems with fans  This alone means there is a much wider range of tablet designs than smartphones  Moreover, the default connectivity for tablets is Wi-Fi rather than a cellular modem  The vast majority of tablets do not have cellular modems, and even fewer customers actually purchase a wireless data plan  As a result, cellular modems are almost always optional discrete components of the platform  The software ecosystem is relatively similar, with Microsoft, Apple, and Google OSes available  Because tablets eschew cellular modems, the time to market is faster, and they are much more commonly sold directly to consumers rather than through carriers  In terms of usage models, tablets are much more PC-like, with reasonable-sized screens that make games and media more attractive 
Looking forward, these distinctions will likely become more pronounced  Many tablets today use high-end smartphone SoCs, but the difference in power targets and expected performance is quite large  As the markets grow in volume, SoCs will inevitably bifurcate to focus on one market or the other  Even today, Apple is doing so, with the A6 for phones and the larger A6X for tablets  Other vendors may need to wait a few years to have the requisite volume, but eventually the two markets will be clearly separate 
Horizontal business model evolution
Another aspect of the mobile device market that is currently in flux and likely to change in the coming years is the business model for the chip and system vendors  Currently, Apple is the only company truly pursuing a vertically integrated model, where all phones and tablets are based on Apple’s own SoC designs and iOS  The tight integration between hardware and software has been a huge boon for Apple, and it has yielded superb products 
Samsung is one of the few others companies that takes a vertically integrated approach to phones and tablets, although in truth its strategy seems to be ambivalent on that point  Unlike Apple, Samsung’s SoCs are readily available to third parties, and some Samsung devices, such as the S7562 Galaxy S Duos, use SoCs from competitors  More recently though, there has been a trend of Samsung devices using Samsung SoCs, at least for the premier products  For the moment, Samsung’s approach is best characterized as a hybrid, particularly as the company lacks a bespoke OS 
The rest of the major SoC vendors (e g , Intel, Qualcomm, Nvidia, TI, Mediatek, etc ) have stayed pretty far away from actual mobile devices  These companies tend to focus on horizontal business models that avoid competing with customers or suppliers 
In the long term, mobile devices are likely to evolve similarly to the PC and favor a horizontal business model  The real advantage is one of flexibility; as costs drop and the market expands, it will be increasingly necessary for vendors like HTC to offer a wide range of phones based on radically different SoCs  While a vertically integrated company like Apple can focus and maintain leadership in a specific (and highly lucrative) niche, it would be very difficult to expand in many growing areas of the market  The differences between an iPhone 6 and a $20 feature phone are tremendous and would be very difficult for a single company to bridge 
However, SoC vendors will attempt to reap the benefits of vertical integration by providing complete reference platforms to OEMs  Conceptually, this is a form of "optional" system integration, where the phone vendor or carrier can get the entire platform from the SoC supplier  This has the principal advantages of reducing time to market while also providing a baseline quality and experience for consumers  Currently, this approach has mostly been tested in emerging markets, but it's likely to become more common over time  There is a crucial distinction between reference platforms and vertical integration  Namely, OEMs can always choose to customize a platform to differentiate, and the SoC vendor avoids dealing with consumers directly  Typically, most of the customization is in terms of software on top of a base operating system 
Quote:Moreover, that will make the transition to a 10nm node even more difficult, as the foundries will have to move from 20nm interconnects to 10nm interconnects and skip a generation The advances in technology lately allowing components on such a small scale to even be envisioned, much less planned for, are truly amazing 
Off topic: show
I present the first generation 'non-technical' rock:
I don't think your horizontal market development theory is supported by facts  Samsung and Apple are more vertically oriented than their competition, for starters  I know this article is narrowly focused on the hardware, but MS and Intel getting into hardware, Amazon getting into hardware, Google buying Moto, this is all vertical integration  How can you support the idea that this trend will be reversed with no real justification? I'm sure mobile chips will continue to specialize, but I don't think this means what you think it means  Automobile companies started making their own engines and with rare exceptions, never went back to being more horizontal  Same with retail and their store brands  Same with cloud companies and their servers  Same with mobile companies and their OSs  The horizontal market of PCs created by long-lasting standards and loose hegemony is the exception, not the norm 
Why wouldn't the foundries be able close the process gap with Intel? Is it a matter of money? Scale?
I'm not so sure about several things:1- Moore's law's relevance  Moore's Law is about ICs  ICs are not as big a part of mobile computers as they are of desktops, even of laptops: screens, batteries, radios are a huge part of tablets' and phones' costs, as opposed to the bare SoC + RAM 2- The tablet vs phone dichotomy  For some reason (probably price insensitivity due to subsidies), Phones have a tendency to be more powerful than Tablets, ie phone SoCs are more than good enough for tablets  Since the OS and peripherals are the same, it makes more sense to design and build just one type of SoC, and just disable the phone-modem part of it (even the other radios are still required: BT, Wifi, GPS   ), same as Intel disable cache and cores for their entry-level CPUs  Once you're fabbing a SoC, it makes more sense to make more of the same than to setup a separate run of a cut-down SoC on an older process, unless volumes are huge  We might still be getting previous-generation, well amortized SoCs in cheaper tablets, though 3- On the contrary, I see a tablet and phone convergence (the ugly phablet)  I'm patiently waiting for the new 6"+ phones to replace my Nook Color and Galaxy Note 1 with a single device 4- The advantage of diversity ? Software is becoming ever more important than hardware  Multiplying SoCs means multiplying product development costs, making support and updates more difficult    Again, unless volumes are huge, OEMs are probaly better off going the way of the car industry and using modular "platforms" housed in different chassis with various screen sizes, keyboards, radios, digitizers   I'm wondering why the "single device" trend does not figure in your analysis  Is it stillborn ? Does it have no impact nor dependency on/with SoCs ?
Samsung has its own bespoke OS: Bada and it is used on an extensive line of devices  I think there are numbers somewhere that it outsold Windows Phone 7 for a time 
gypsumfantastic wrote:Why wouldn't the foundries be able close the process gap with Intel? Is it a matter of money? Scale?First mover advantage 
SoC? System on a Chip I guess?
You're way off on the Moore's Law/cost of smartphones point  The processors used in today's high-end smartphones are already cheap, around $25  And there are less expensive options if you want a lower end product  In fact, the hardware in the whole smartphone is relatively cheap  Analyst's estimate the Z10's materials cost around $160, the iPhone 5 around $140  They're using expensive glass and metals, then there's the battery, memory, etc  which means the processor is a small factor of the cost And then there's the jump from $140 in materials to the unsubsidized costs  The reason these phones cost $650 is because of the high margins these companies are able to get and the high cost of hardware design and/or software development  But the point is that making the processors 4 times better/cheaper isn't going to change the economics of the smartphone  What will change the economics is commoditized designs and software and cheaper materials all around  Then you'll have a $50 smartphone that's decent 
Last edited by ggeezz on Wed Feb 13, 2013 9:17 am
bigterp wrote:SoC? System on a Chip I guess?Yup 
gypsumfantastic wrote:Why wouldn't the foundries be able close the process gap with Intel? Is it a matter of money? Scale?Money and momentum, the x86 market is a huge money maker for Intel so it is able to recoup its huge investments for advanced foundries 
Quote:Currently, the only products using 3D integration are FPGAs from Xilinx,Doesn't Sony use it in the PS Vita? I thought I read somewhere that they had the CPU, main memory (2 dies) and video memory, so 4 dies in total, sitting on top of each other all on the same chip 
renoX wrote:gypsumfantastic wrote:Why wouldn't the foundries be able close the process gap with Intel? Is it a matter of money? Scale?Money and momentum, the x86 market is a huge money maker for Intel so it is able to recoup its huge investments for advanced foundries Exactly and I would clarify that it's all about margins, the difference between what it costs to make a chip and what it sells for  The margins for desktop and server processors is huge because a) the whole product is expensive so $200 to $1000 for the chip is acceptable, and b) Intel has huge advantages in that space and little competition So Intel can afford to do the R&D to stay ahead of the curve and keep their position  When your smartphone chip sells for $25 you can't do the R&D to leapfrog a company that sells Xeons for $1000 and Core i5's for $200 
I am happy to see Kanter here at Ars, I like his writing and he maintains Real World Tech, where Linus Torvalds often shows up to comment on CPU arch and other interesting topics 
ggeezz wrote:renoX wrote:gypsumfantastic wrote:Why wouldn't the foundries be able close the process gap with Intel? Is it a matter of money? Scale?Money and momentum, the x86 market is a huge money maker for Intel so it is able to recoup its huge investments for advanced foundries Exactly and I would clarify that it's all about margins, the difference between what it costs to make a chip and what it sells for  The margins for desktop and server processors is huge because a) the whole product is expensive so $200 to $1000 for the chip is acceptable, and b) Intel has huge advantages in that space and little competition So Intel can afford to do the R&D to stay ahead of the curve and keep their position  When your smartphone chip sells for $25 you can't do the R&D to leapfrog a company that sells Xeons for $1000 and Core i5's for $200 Spot on Intel are able to piggyback other development efforts off the highly lucrative mainstream x86 market which generates the huge sums of money to fund their amazing fab technology The question for the future is how the economics will stack up when overall device costs fall significantly and there is a big downward pressure on SoC prices  In that situation, can Intel still justify bringing their A-game to a market where products are essentially commoditised and you have processors selling for a only a few dollars each?The lesson from their previous involvement in the DRAM market is that they probably won't want to be involved because there isn't enough money to be made to justify manufacturing phone SoCs on a cutting edge, or near cutting edge process  In that scenario, Intel may not totally abandon the market but they might just stick to manufacturing SoCs on nodes that are a step or two behind the state of the art 
solomonrex wrote:I don't think your horizontal market development theory is supported by facts  Samsung and Apple are more vertically oriented than their competition, for starters  I know this article is narrowly focused on the hardware, but MS and Intel getting into hardware, Amazon getting into hardware, Google buying Moto, this is all vertical integration  How can you support the idea that this trend will be reversed with no real justification? I'm sure mobile chips will continue to specialize, but I don't think this means what you think it means  Automobile companies started making their own engines and with rare exceptions, never went back to being more horizontal  Same with retail and their store brands  Same with cloud companies and their servers  Same with mobile companies and their OSs  The horizontal market of PCs created by long-lasting standards and loose hegemony is the exception, not the norm Yea, each year Amazon, MS, Apple and Google look more and more the same 
Intel cannot abandon the phone/tablet market  Desktop/laptop sales are stagnating/decreasing and phones/tablets are on the rise  This trend is only going to increase going forward But you're right, they're going to have use their fabs that are a step or two behind the cutting the edge  But they're going to have to up their game in the tablet space to even be able to do that 
gypsumfantastic wrote:Why wouldn't the foundries be able close the process gap with Intel? Is it a matter of money? Scale?Intel's called Chipzilla for a reason up
Lagrange wrote:The question for the future is how the economics will stack up when overall device costs fall significantly and there is a big downward pressure on SoC prices  In that situation, can Intel still justify bringing their A-game to a market where products are essentially commoditised and you have processors selling for a only a few dollars each?The lesson from their previous involvement in the DRAM market is that they probably won't want to be involved because there isn't enough money to be made to justify manufacturing phone SoCs on a cutting edge, or near cutting edge process  In that scenario, Intel may not totally abandon the market but they might just stick to manufacturing SoCs on nodes that are a step or two behind the state of the art I think the processing is a bigger advantage than many realize  If Intel can stay ahead in process design - which this article seems to indicate - they should have a major advantage  All else being equal a 14nm chip should be significantly faster and more efficient than the same chip at 22nm  Add in the fact that yields increase geometrically - you can fit a lot more 14nm chips on a given wafer size vs 22nm (or 32nm for the other manufacturers ) and you have a very appealing proposition  And then add in the fact that Intel actually has a pretty good graphics stack and IP  It's not a sure thing by any means, but I suspect ARM may have just prodded a sleeping giant edit: Also worth noting, Intel, TSMC, and Samsung are the only manufacturers who are building out 450nm wafers  This will increase yields dramatically  Of course Samsung and TSMC will build ARM out, but it definitely puts quite a bit of pressure on all other manufacturers  As the article mentions Intel and Samsung are the only ones who control production top to bottom, and Samsung must share some of the benefits with ARM 
As someone who has worked in the semiconductor industry for longer than contemporary fanboys have existed, I'm getting a bit fed-up seeing many of these articles which rewrite history with analyses distorted by the lens of the contemporary Apple or Samsung fanboy The mobile industry moved to horizontal integration a long time ago  Better indicators than these odd contemporary obsessions with the relatively non-innovative Samsung and Apple where when Motorola spun out its semiconductor division as Freescale, Nokia stopped making it's own custom designs with TI and ST, and Ericsson spun out it's Ericsson Mobile Platforms division and formed ST-Ericsson with ST The true innovation in the mobile market was done a decade or more ago mainly by Moto/Nokia/Ericsson/TI/Qualcomm, and Samsung and Apple had little to do with it  Under the hood most stuff has been on a simple linear evolutionary path by the SoC providers since then  The phone manufacturers have then mainly been simply sticking these off-the-shelf SoCs (and their included low-level software stacks) in a box, a job made all the easier with the SoC manufacturer collaboration providing the bulk of the work for the AOSP 
Last edited by paul5ra on Wed Feb 13, 2013 11:06 am
introiboad wrote:I am happy to see Kanter here at Ars, I like his writing and he maintains Real World Tech, where Linus Torvalds often shows up to comment on CPU arch and other interesting topics Indeed  Most tech writing in this area is atrocious  This piece is one of the few well informed articles I've read in a long time 
ggeezz wrote:Intel cannot abandon the phone/tablet market  Desktop/laptop sales are stagnating/decreasing and phones/tablets are on the rise  This trend is only going to increase going forward But you're right, they're going to have use their fabs that are a step or two behind the cutting the edge  But they're going to have to up their game in the tablet space to even be able to do that The word you're looking for is Haswell, as far as I know 
Mabsark
ggeezz wrote:Intel cannot abandon the phone/tablet market  Desktop/laptop sales are stagnating/decreasing and phones/tablets are on the rise  This trend is only going to increase going forward But you're right, they're going to have use their fabs that are a step or two behind the cutting the edge  But they're going to have to up their game in the tablet space to even be able to do that Actually, that trend will not simply keep increasing going forward  The reason desktop/laptop sales are stagnating/decreasing is due to the fact that most people already have one and therefore don't need to buy another one  The exact same thing will happen with tablets as well  Sales are increasing now because people without tablets are buying them  When most people already own a tablet, they won't be buying a new one every year and therefore sales will stagnate/decrease The PC market is saturated and in a couple of years, the tablet market will be saturated too  Basically, in order to increase sales in a saturated market, you need to increase the population growth or decrease the longevity of the product 
gypsumfantastic wrote:Why wouldn't the foundries be able close the process gap with Intel? Is it a matter of money? Scale?Probably a mix of a lot of things  One big thing was during this recession, Intel was the ONLY fab company that didn't scale back their R&D  That alone gave Intel a large advantage Intel has almost always been ahead  One of the reasons could be that Intel works with much higher margins than many of the commodity companies like Samsung and TSMC Outside of the P4 flop and some of the monopolistic abuses, Intel has typically been selling to high end customers that are willing to pay a premium for "the best" Intel has a large benefit of having a relatively "good name" when it comes to CPUs, so they can effectively charge a brand-name premium I'm sure there are other reasons, and probably better reasons, but these are the main ones that I think of 
Mabsark wrote:Actually, that trend will not simply keep increasing going forward  The reason desktop/laptop sales are stagnating/decreasing is due to the fact that most people already have one and therefore don't need to buy another one  The exact same thing will happen with tablets as well
Context 3: The major actions taken by the board of directors and council during the national meeting in Chicago were reported in C&EN, April 30 (page 32) 
The Society Committee on Budget & Finance met on Saturday, March 24, to review the society's 2006 financial performance  The society ended 2006 with a net contribution from operations of $12 2 million, on revenues of $424 0 million and expenses of $411 8 million  This was $7 8 million favorable to the approved budget 
After including the results of the Member Insurance Program and new ventures, the society's overall net contribution for 2006 was $11 5 million, which was $7 4 million favorable to the approved budget  The favorable variance was primarily attributable to higher than budgeted electronic services revenue and investment income, as well as expense savings from lower than budgeted health care costs and reduced IT spending  In addition, the society ended the year in compliance with the board-established financial guidelines 
The Society Committee on Education (SOCED) received an update from President Catherine Hunt on the thematic programming featured in Chicago focusing on the sustainability of energy, food, and water  President-Elect Bruce Bursten solicited input from the committee pertaining to the central role of education in his agenda  SOCED received a presentation from the Membership Affairs Committee on its white paper on membership requirements 
Committee members strongly support the proposal to include undergraduates as members of the society, but they requested that financial arrangements be clearly spelled out in the petition to ensure that the highly successful Student Affiliates program remains intact  The committee discussed the Education Division programs that were reviewed in 2006 and those that will be reviewed in 2007, under the auspices of the Program Review Advisory Group  SOCED received an update from the Committee on Professional Training regarding the draft ACS guidelines for approval of bachelor's degree programs in chemistry 
Committee members discussed the report prepared by the Globalization Task Force, focusing on those sections relevant to education  The committee suggested initiatives related to the new ACS strategic plan, including a potential program that would engage retired chemists in the K-12 classroom  SOCED created a task force to consider the role of online, or "virtual," simulations in the chemistry laboratory, recognizing the value of online/virtual experiences as a supplement to, but not a replacement for, hands-on laboratory experiments 
The committee ratified two interim actions taken since the Dec  3, 2006, meeting: to remove the financial restriction of the ACS Petroleum Research Fund (ACS PRF) Supplement for Underrepresented Minority Research Programs (SUMR) and to contact nominators whose nominations for the Volunteer Service Award had expired and to invite them to reactivate their nomination packet for the 2008 Volunteer Service Award 
Acting under delegated authority, the committee voted to accept the recommendations of the ACS Petroleum Research Fund Advisory Board (February 2007 meeting) for funding grants totaling $5 2 million; voted to recommend to the board a screened list of six nominees (due to a two-way tie for fifth place) for the 2008 Priestley Medal; voted to recommend to the board a screened list of five nominees for the 2008 Award for Volunteer Service to ACS; on the recommendation of the ACS Committee on Frasch Foundation Grants, voted to recommend to the board that it recommend to the trustee (US Trust) of the Frasch Foundation 12 grants for research in agricultural chemistry for the period of 2007–12; voted to recommend to the ACS Board of Directors that a new national award be established, the "ACS Award for Affordable Green Chemistry," sponsored by Rohm and Haas; and voted to recommend to the ACS Board of Directors that a new endowment be established, the "Affordable Green Chemistry Endowment Fund," to support the award 
The committee also reviewed the final report from the Special Board Task Force on the Review of the ACS National Awards Program, chaired by Ronald Breslow; established a Canvassing & Selection Subcommittee; and reviewed a list of external awards for which ACS may want to nominate candidates  The committee agreed to include the list of significant external awards in the awards locator database that is being developed 
The committee was updated on efforts to reconcile ACS's technical divisions' desires to leverage national meeting content using the Internet with our journal editors' concerns about prior publication issues  A conference call on this issue was scheduled for April 21, 2007 
The committee received a presentation on the recent actions of the ACS Board of Directors International Strategy Group (ISG)  The group's charge is to develop recommendations for a short- and long-term international strategy for the society 
The committee was updated on the status of the activities of the Board Oversight Group on Leadership Development (BOG)  Potential solutions for the unexpectedly high cost of facilitator training and transitioning from the current Leaders Conference format to the newly designed curriculum were presented to the committee 
The committee reviewed plans for conducting the 2007 Membership Satisfaction Survey  Preliminary results are expected in May or June with a final report to be delivered to the board at the 2007 Boston national meeting 
The committee received a briefing on the status of the MORE Project: Multidisciplinary Opportunities though Resource Enhancement  Twenty-eight proposals were received, and a decision on which proposals to support will be made in early May 
The chair led a discussion on draft 2007 committee goals, and committee members offered several suggestions related to successfully meeting them  One suggestion was to modify a communications goal to make it more completely reflect the duties of the committee outlined in the board regulations  The chair and committee members will examine the suggestion and revisit the question after the board retreat where board committee duties will be examined 
ACS President Hunt discussed her 2007-08 Presidential Task Force on Enhancing Science & Technology, which is charged with developing advocacy best practices that can enhance ACS's attainment of its public policy priorities  The task force is composed of a diverse set of ACS members as well as former U S  Representative and chairman of the House Science Committee, Sherwood Boehlert, who will cochair the task force 
• Results of the 2007 Public Policy Priorities Survey, which resulted in a four-tiered ranking of ACS's 2007 public policies  The ranking will help focus staff resources in conducting outreach and advocacy on behalf of ACS members 
• The hiring of a communications consulting firm for 2007 to assist ACS in implementing the initial phase of the ACS Strategic Communications Plan 
• Creation of a pilot ACS state government affairs advocacy program  Committee members agreed to the creation of a pilot, and staff will propose an initial list of states, policy focus, and a budget to carry out the program 
The committee met in executive session on March 23 and in open session jointly with the Joint Board-Council Committee on Publications and the Division of Chemical Information on March 26 
The committee heard from Chemical Abstracts Service (CAS) management on a range of issues including a report on continuing database building efforts, product enhancements, and CAS's centennial celebration plans 
The Committee on Chemical Safety (CCS) provides advice on the handling of chemicals and seeks to ensure safe facilities, designs, and operations by calling attention to potential hazards and stimulating education in safe practices 
CCS has several publications (many downloadable), including the flagship publication, "Safety in Academic Chemistry Labs" (SACL)  Work has recently started on the translation of SACL into Arabic  This is in addition to the online Spanish version of SACL  Also online are the "Student Lab Code of Conduct for Secondary Science Programs" and a security vulnerability analysis checklist  A K-12 restricted hazardous substances list is under development  The third edition of the "Chemical Safety Manual for Small Businesses" will be ready soon 
The committee's Task Force on Laboratory Environment, Health & Safety is working on a new edition of "Laboratory Waste Management " Task force members also commented on the recent Environmental Protection Agency Proposed Rule for Hazardous Waste in Academic Laboratories  Our Video Safety Resources Task Force is developing video resources to be distributed over the Web 
CCS has been involved in collaborations for the updating of publications like "Prudent Practices in the Laboratory" and "ACS Guidelines for the Teaching of High School Chemistry " Along with other ACS units, CCS is exploring participating in the EPA's School Chemicals Cleanout Campaign 
The Committee on Chemists with Disabilities (CWD) met at the 233rd ACS national meeting, Chicago, on Monday, March 26  Judy Summers-Gates reported on the Joint Subcommittee on Diversity meeting  This subcommittee is made up of representatives of the five committees that support people in chemistry (as opposed to a category of the profession): CWD, Committee on Minority Affairs, Committee on Technician Affairs, Women Chemists Committee, and Younger Chemists Committee, and its goal is to develop ways to coordinate the efforts of the five groups 
The CWD Ambassador Program that was announced at CWD's 25th anniversary celebration at the Washington, D C , meeting was discussed  Zelda Wasserman reported on the status of the letter from CWD to the ACS Board regarding captioning of ACS video materials  Janelle Kasper-Wolf, of ACS staff, discussed adding new questions to the ACS annual employment salary survey to obtain information for the committee 
At the Chicago national meeting, the Committee on Community Activities (CCA) partnered with the ACS Education Division and the Office of the President to host "Chemistry In Action—It's Easy Being Green" at the Peggy Notebaert Nature Museum on Saturday, March 24  More than 250 children participated in the hands-on activities focused on recycling  ACS President Hunt presented a Salutes to Excellence plaque to the museum for its dedication to community outreach 
The Chemists Celebrate Earth Day celebration occurred in 120 local sections with 138 coordinators leading the efforts within their communities  This represents an increase of more than 30% in local section and coordinator participation from 2006 
CCA was featured in C&EN's April 16th issue on page 53  A shortcut to CCA's homepage was created: chemistry org/committees/cca html 
During the Boston national meeting, CCA and the Office of Community Activities will celebrate National Chemistry Week's 20th Anniversary and its theme, "The Many Faces of Chemistry " A special outreach event is being planned for Sunday, Aug  19  Hands-on activities will focus on health and wellness 
The Committee on Corporation Associates (CCA) advises and influences ACS to ensure that its products and services are of value to industrial members and their companies  CCA vice chair, Roslyn White (SC Johnson), provided an overview of recent interactions between Corporation Associates and the U K -based Society of Chemical Industry (SCI) 
CCA gave feedback to a recommendations report from the ACS Board Committee on Professional & Member Relations Task Force on Globalization  Presentations were also received from the ACS Green Chemistry Institute and SCI 
Staff reported on the Department of Industry Member Programs' activities since the San Francisco meeting  The report covered the Regional Industrial Innovation Awards, the World Congress on Industrial Biotechnology, the Analytical Pavilion sponsored by C&EN, and the ACS/Pharma Leaders Meeting 
The Awards/Finance & Grants Subcommittee reported that CCA received two funding proposals that total $7,500  Funding was provided to the following: The Committee on Economic & Professional Affairs at $3,000 for the Chicago symposium on "Benefits Trends for the Chemical Workforce" and the Office of Graduate Education and the Department of Career Development & Management at $4,500 for a workshop on "Preparing for Life after Graduate School," to be held in conjunction with the 39th Central Regional Meeting 
The subcommittee also requested that ACS staff provide CCA with an official annual statement of Corporation Associates' financial reserves as of Jan  1 of each year 
The Programs Subcommittee reported on planned programming activities in 2007 and beyond between CCA and SCI  The subcommittee gave an update on a Boston symposium cosponsored by Corporation Associates and the Medicinal Chemistry Division featuring past ACS Heroes of Chemistry from the pharmaceutical industry 
By request of the subcommittee, representatives from Chemical Abstracts Service gave an overview on AnaVist—a tool with potential applications for CCA's efforts to provide member companies with industry-relevant information and reports  The subcommittee also requested that CCA earmark approximately $20,000 of Corporation Associates funds in 2008 for its activities 
The Educational Outreach Subcommittee reported on its decision to collaborate with the Graduate Student Symposium Programming Committee of the Chemical Education Division on a graduate student industry roundtable program in Boston 
The subcommittee requested $5,000 in support of this effort  The subcommittee also discussed a request for corporate executive support of an American Association of Physics Teachers initiative to promote undergraduate research 
The Committee on Environmental Improvement (CEI) continues to be focused on the sustainability of the chemical enterprise  In Chicago, the committee introduced a multiyear effort to make ACS meetings more sustainable  This effort is designed to take advantage of the large size and diverse programs of the society to lead in the sustainability arena by "walking the talk "
The committee held a dialogue with representatives of the U S  Environmental Protection Agency who are trying to "green" federal conferences and work with the travel and tourism industry to change practices and shrink the environmental footprint of meetings  The committee also used advertising and student volunteers to engage individual meeting participants in a campaign to increase recycling by asking "Are you sustainable?" Moving forward, CEI looks forward to working closely with the Committee on Meetings & Expositions to advance this agenda 
CEI was also pleased to participate in the meeting theme on sustainability through the ACS presidential programming  CEI cohosted the Monday presidential luncheon to discuss sustainability issues with the Committee on Science and is leading the follow-up to that luncheon, which will include recommendations on advancing sustainability in the three focal areas of the meeting—energy, food, and water 
The committee also continued its dialogue with the Committee on Corporation Associates about a collaborative workshop  This activity, tentatively slated for the New Orleans meeting, will seek additional insights from chemical and allied products companies about public policy barriers that limit adoption of more sustainable products and practices as well as policy incentives that would lead to increased sustainability in the chemical enterprise 
At its Chicago meeting, the committee welcomed the president of the Jordanian Chemical Society and the past-president of the Arab Union of Chemists 
The committee was briefed on Pittcon 2007, where, with financial support from the Society of Analytical Chemists of Pittsburgh, ACS coordinated participation of a scientific delegation from Adriatic nations 
The committee heard reports on the 2007 Frontiers of Chemical Science III: Research & Education in the Middle East meeting; the 2007 Transatlantic Frontiers of Chemistry meeting, which was jointly sponsored by ACS, the German Chemical Society, and the Royal Society of Chemistry; planned workshops to engage U S  and Chinese early-career scientists in chemical biology, supramolecular, and new materials chemistry; and ACS Discovery Corps U S /Brazil Research Collaboration Project in Biomass Conversion to Biofuels, Biomaterials & Chemicals 
The committee discussed Latin American engagement opportunities created through Puerto Rico's involvement in three key chemical science events there: the 2009 ACS Southeast Regional Meeting, the 2008 Federation of Latin American Chemical Associations (FLAQ) meeting, and the proposed IUPAC 2011 Congress & General Assembly 
The committee heard reports on letter-writing efforts by the ACS president to government officials in Libya and Mexico expressing concerns about challenges to the scientific freedom and human rights of scientists there 
The Committee on Minority Affairs (CMA) approved new vision, mission, and values statements at the Chicago national meeting  The mission of CMA is to increase the participation of minority chemical scientists and influence policy on behalf of minorities in ACS and the chemical enterprise 
An aggressive new strategic plan was approved by CMA to guide its activities over the next three years  By the end of 2009, CMA will increase the number of ACS Scholars that graduate to 100 per year, add 100 new minorities to leadership positions in ACS, engage in several collaborations, and increase the number of minority members of ACS by 5,000  CMA will focus initially on increasing minorities in ACS leadership  In working toward this goal, CMA began work on two new leadership-development programs for minority chemists 
CMA continues to support the work of the Joint Subcommittee on Diversity (JSD) in developing programs, products, and services to ensure full participation of all members in ACS  In Chicago, JSD premiered a diversity booth at the meeting exposition hall and cosponsored symposia 
The Committee on Patents & Related Matters (CPRM) discussed proposed legislative and regulatory changes to the U S  patent system as well as open-access legislation and the potential effects such matters might have on industry and academia as well as on ACS 
CPRM also continued its work on several new educational tools to assist and inform members on patent issues and other intellectual property matters important to a successful career in the chemical enterprise  Many of these tools are now available on the committee's expanded website, membership acs org/C/CPRM/ 
At the March 2007 meeting, the Committee on Professional Training (CPT) reviewed 42 new and additional information reports from ACS-approved chemistry programs  CPT held conferences with four schools seeking approval, discussed three updates and five site visit reports, and approved three new schools  The total number of ACS-approved chemistry programs is now 642 
The committee released the full draft of the ACS guidelines for review and comment  Copies of the draft were distributed to the department chairs at all ACS-approved schools, the chairs of all ACS committees, and the chairs of all ACS technical divisions 
Several CPT members met with the ACS technical divisions during the Chicago meeting to present an overview of the draft and obtain feedback  The draft guidelines document is available on the CPT website, and the committee invites any comments to be sent to cpt@acs org 
In other business, the committee continued development of the two workshops with minority-serving institutions that will be held in 2007  The committee reviewed the editorial policies for the 2007 edition of the ACS Directory of Graduate Research, which is using a new protocol for retrieving research publication titles in an effort to improve the accuracy of the directory 
C&EN finished 2006 with an exceptionally strong editorial package  The first months of 2007 are proving to be equally successful in fulfilling the magazine's mission of keeping its readers informed  On the advertising side, revenues in 2006 increased for the second year in a row, and the early months of 2007 show continuing positive signs  The most significant editorial achievement was the successful launch of the redesign of the print edition of C&EN with the Oct  16, 2006, issue 
The Subcommittee on Copyright has successfully updated the Copyright Module on the ACS Publications website  The subcommittee is looking into the possibility of conducting copyright programs at future ACS national and regional meetings 
The final monitoring reports for Chemistry of Materials, Journal of Agricultural & Food Chemistry, and Molecular Pharmaceutics were presented and accepted by the committee  Journal of Chemical Information & Modeling, Organic Letters, Accounts of Chemical Research, and the Journal of Chemical Theory & Computation will be monitored next 
3  Examining the scientific basis of public policies related to the chemical sciences and making recommendations to the appropriate ACS units 
In the first of these areas, ComSci partnered with President Hunt and the Committee on Environmental Improvement in planning and hosting a sustainability luncheon that featured roundtable discussions centering on a key sustainability question  At the Boston national meeting, ComSci will deliver a full-day program on the subject of "Partnerships in Innovation & Competitiveness "
Regarding the second thrust, ComSci will present two programs in Boston: a box lunch that will feature two speakers taking opposing sides on the subject of "Genetic Screening & Diagnostic Testing: Do You Really Want to Know?" and a symposium titled "Creating & Sustaining International Research Collaborations "
In support of the last thrust, ComSci is planning two events for 2008: "Balancing Security & Openness" will gather data to determine if the recent emphasis on security is hindering scientific progress and "Transitioning Chemical Science to Commercially Successful Products "
The Women Chemists Committee (WCC) hosted more than 70 attendees at its open meeting recently in Chicago, where representatives from Iota Sigma Pi, Women in Science & Engineering, the Association of Women in Science, and the Chicago local section helped WCC celebrate the committee's 80th anniversary 
The Women in Industry Breakfast was also highly successful with a new format of speed networking  More than 100 participants had the opportunity to practice their elevator speeches and make several professional connections  A related workshop will be offered by WCC in Boston 
In Chicago, WCC sponsored two symposia, "Women Achieving Success: The ACS as a Platform in Leadership Development" in honor of Madeleine Joullié's 80th birthday and the ACS Award for Encouraging Women into Careers in the Chemical Sciences: Symposium in Honor of Bojan H  Jennings 
More than 225 ACS meeting attendees were present for the biannual WCC Luncheon and heard the keynote speaker Laura Kiessling, 2007 Francis P  Garvan-John Olin Medal Recipient  Twelve women presented their research at this meeting with funding by the WCC/Eli Lilly Travel Grant Award  WCC members also spent time educating expo attendees on programs offered by the ACS Office of Diversity Programs at its new booth 
In Chicago, the Younger Chemists Committee (YCC) welcomed its new committee members with an information session centered on YCC's charter as well as on its strategic plan: to make ACS relevant to younger chemists, to involve younger chemists in all levels of the society, and to integrate younger chemists into the profession 
In January, YCC again hosted a Leadership Development Workshop during the ACS Leaders Conference  There were more than 80 applications for the 15 awards, which covered travel and registration for the conference  YCC plans to again fund the travel awards and provide leadership training for young chemists in 2008  YCC also solicited applications and selected a new graduate student representative on the Graduate Education Advisory Board 
During the Chicago meeting, YCC programs included "Starting a Successful Research Program at a Predominantly Undergraduate Institution," "Career Experiences at the Interface of Chemistry & Biology," and "Chemistry Pedagogy 101 "
In addition to these programs, YCC cosponsored five programs with various committees and divisions  YCC continues to reach out to ACS committees and divisions and has initiated liaisonships with 11 technical divisions to encourage technical programming that highlights the contributions of younger chemists  Looking forward to Boston, YCC is planning symposia including "The Many Faces of Chemistry: International Opportunities for Chemists"; "Being a Responsible Chemist: Ethics, Politics & Policy"; and "Changing Landscapes of the Bio-Pharma Industry "
The Committee on Committees (ConC) conducted its annual training session for new national committee chairs at the ACS Leaders Conference in January 2007  ConC's interactive session for committee chairs in Chicago served as an opportune follow-on and a forum for informative interchange among seasoned and new chairs 
ConC began developing its recommendations for the 2008 committee chair appointments for consideration by the president-elect and chair of the board  ConC continues to focus efforts to identify members with the skills and expertise specified by the committee chairs using the councilor preference form 
The form will be sent to councilors in May  ConC also seeks the names of noncouncilor members for consideration for service on council-related committees, especially those with no prior appointment 
As part of ongoing activities with the joint CPC-Board Governance Review Task Force, ConC has collected data on committee liaisons to other committees  This information will be distributed to committee chairs  The number of liaisons indicates that unofficial but strong communication channels exist within the ACS committee structure 
On Sunday evening, the Committee on Nominations & Elections (N&E) sponsored its fifth successful Town Hall Meeting for President-Elect Nominees  An estimated 200 people attended this session  This forum facilitated communication among the 2008 president-elect nominees, councilors, and other members  N&E will hold another Town Hall Meeting featuring the candidates for director-at-large at the fall meeting in Boston 
Now that voting over the Internet has become an accepted procedure for ACS national elections, the ACS technical divisions and local sections have expressed strong interest in using this method for their elections  N&E has developed protocols for elections for local sections and divisions  This document will be forwarded to the appropriate committees for their review and distribution 
N&E is responsible for reviewing annually the distribution of member populations within the six electoral districts to ensure that the districts have equitable representation  According to bylaw V, section 4(a), the member population of each electoral district must be within 10% of the result of dividing by six the number of members whose addresses lie within these districts  The committee is happy to report that the six electoral districts are in compliance 
The committee has developed a petition on election procedures for president-elect and district director  The proposed election mechanism provides for a preferential (ranked) ballot and an "instant runoff " N&E continues to address the areas of campaigning and the timing of our national election process  Between the Chicago and Boston meetings, the committee plans to sponsor online forums for input from councilors and other interested members on these issues 
In response to member concerns regarding the collection of signatures for petition candidates, N&E reviewed the society's bylaws  The bylaws state that an endorsement is required, but does not stipulate the method of endorsement  N&E has determined that original or electronic signatures are acceptable and will establish appropriate procedures for receipt of electronic signatures 
The Committee on Constitution & Bylaws (C&B), acting for the council, issued new certified bylaws to the Corning Section, the Portland Section, the Division of Colloid & Surface Chemistry, and the Division of Chemical Education  The committee reviewed new proposed amendments for the Division of Medicinal Chemistry, the Columbus Section, the Detroit Section, and the Southern Arizona Section 
Three petitions were presented to council for action at this meeting  Regarding the "Petition on Election Procedures 2006," a motion to separate the petition was approved, and the petition was divided  Provisions affecting bylaw V, sec  2d, bylaw V, sec  3c, and bylaw V, sec  4f, which deal with election procedures and the timing of run-off elections, were approved by council and will become effective following confirmation by the board of directors 
The second part of the petition regarding bylaw V, sec  2c, and bylaw V, sec  3b, which deal with signature requirements for petition candidates for president-elect and director-at-large respectively, was recommitted to the Committee on Nominations & Elections, which has primary substantive responsibility for the petition 
The Committee on Nominations & Elections was asked to reconsider the signature requirements, procedures for acceptance of electronic signatures, and recommendations from the Governance Review Task Force on election procedures 
The second petition presented to council for action was the "Petition on Rules for Nominating Members of N&E for National Offices " This petition was not approved by council  The third petition, the "Petition on Multiyear Dues," was amended by incidental motion on the council floor, calling for the petition to become effective when technical components are instituted to track payments, but no later than Jan  1, 2010  Council approved the incidental motion and then approved the petition 
The committee reviewed one petition for consideration, the "Petition on Local Section Affiliations," which will be submitted to council for action at the fall 2007 meeting in Boston 
The committee met with representatives of the Committee on Membership Affairs and the Governance Review Task Force to continue discussions on proposals currently being formulated on membership requirements and student membership  In addition, the committee discussed election issues of concern to the Southern California Section 
We hope you enjoyed the presidential and division thematic program, "Sustainability of Energy, Food & Water" in Chicago  A small, dedicated group of volunteers and staff labored tirelessly to create and coordinate this programming; to them the Committee on Divisional Activities (DAC) offers sincere thanks 
DAC has committed to transfer the process of choosing and organizing future national meeting themes to a body that represents all divisions  We made substantial progress in Chicago, where division, secretariat, and committee representatives convened to discuss national meeting program concepts  They proposed themes for the 2008 Philadelphia national meeting as well as a framework for a future national programming group 
Divisions have successfully served their members fortunate enough to attend national meetings  To maximize benefits to division members, DAC encourages divisions to consider extending the reach of the content they deliver at national meetings through Internet-based distribution channels and will support worthy efforts in this direction via Innovative Program Grants 
The committee voted in Chicago to propose modifications to the division funding formula that will more greatly reward interdisciplinary programming  The new formula will also be simpler and more transparent to divisions  DAC will present the revised plan to council for action in Boston 
The Committee on Economic & Professional Affairs (CEPA), working with ACS staff in the Departments of Career Management & Development and Member Research & Technology, continues to update and implement its strategic plan to address the career needs of society members 
Specifically, the committee reviewed and revised existing workshops and materials to help ACS members get jobs  CEPA is developing new programs to address the needs of mid- and late-career chemists to ensure their continued competitiveness in the workplace and to ease their career transitions  New initiatives in these areas include the development of workshops, online training, surveys to assess member needs, suggested changes to public policies, and updates to professional and ethical workplace guidelines  As a result of discussions at the Public Policy Roundtable, which was held in San Francisco, a background paper is being developed on trends in health care issues 
The newly revised "Chemical Professional's Code of Conduct" was presented to council, which approved it  The Standards & Ethics Subcommittee is preparing a revision of the "Academic Professional Guidelines" to be presented to council for consideration in Boston 
CEPA reviewed the Globalization Task Force Report  As our science diffuses around the globe, we want to make sure that our members are aware of the economic and professional challenges they will face and that they have the tools they need to succeed  Therefore, CEPA made a commitment to work with other committees, divisions, and ACS staff to develop programs and policies that position our membership to compete in the global workforce 
CEPA heard and discussed a presentation on the proposal from the Membership Affairs Committee on broadening the requirements of membership  CEPA supports the spirit of this proposal and encourages further detailed studies to assess financial impacts on local sections and student affiliates chapters 
The Local Section Activities Committee (LSAC) recognized local sections celebrating significant anniversaries in 2007, including Savannah River (50 years), Northeast Tennessee (75 years), and the St  Louis and Syracuse local sections (both celebrating 100 years) 
LSAC hosted the local section leaders track in conjunction with the ACS Leaders Conference in Baltimore on Jan  26–28  A total of 135 delegates from 124 local sections participated in the weekend leadership conference 
LSAC also hosted a Local Section Summit on March 2–4 in Arlington, Va  The summit focused on practical operational issues that will support local sections' long-term success  Specific areas that were discussed include the development of a multiyear plan to expand or develop programming for local sections, opportunities to encourage innovation and experimentation within and among local sections, and capitalizing on existing opportunities to facilitate partnerships between local sections and other ACS groups 
Following the San Francisco national meeting, LSAC launched a local section Science Café minigrant program  Fifty-five local sections accepted LSAC invitation to host Science Cafés in 2007 
A DVD entitled "ACS Close to Home: Local Sections Connecting Chemistry & the Community" was released earlier this year  The video provides a seven-minute overview of the many outreach and educational programs sponsored by local sections and the critical role they play in positively influencing the public's perception of chemistry and its practitioners  Copies of the DVD were sent to all local section officers 
The Committee on Meetings & Expositions (M&E) reported that the 233rd ACS national meeting hosted 14,520 attendees  This included 7,152 chemical scientists, 5,059 students, 1,283 exhibitors, 119 precollege teachers, 573 exposition visitors, and 453 guests  The exposition had 424 booths with 268 companies 
The 10 2006 regional meetings set a new standard for excellence with attendance exceeding 8,000, a 30% increase in average meeting attendance compared to the 2005 meetings  A total of 4,717 abstracts were submitted  A region summit was held in February at which the final report of the ReACT study group was reviewed 
The practice of tracking the number of presenter no-shows continues  M&E will collaborate with the Committee on Divisional Activities to study options for addressing this problem  Suggestions will be presented at the Boston meeting for implementation in 2008 
It is the intent of M&E to pursue the goal of making our meetings "greener " We will communicate with staff and governance units to identify actions for both the short and long term 
The American Institute of Chemical Engineers (AIChE) and ACS will hold their 2008 spring meetings simultaneously in New Orleans  An ad hoc working group consisting of members from M&E, DAC, and AIChE are actively exploring joint programming opportunities for this meeting 
The Committee on Membership Affairs (MAC) met in executive session on Saturday and Sunday in Chicago and reported that the ACS closed 2006 with 160,491 members, our highest year-end membership count since 2002  Of the 17,857 applications processed in 2006, more than 1,000 came from the Member-Get-a-Member campaign in which many councilors participated  The society's retention rate in 2006 remained strong at 92%  The committee also reported that recruitment for the first two months of 2007 netted 2,844 new applications—729 more than for the same time period last year 
MAC continues to work with deliberate speed on the proposed new bylaw language for members, student members, and society affiliates-the three ways to connect to the society  The committee received input from the Governance Review Task Force and its action teams, the Council Policy Committee, the board of directors, the Committee on Constitution & Bylaws, and several other committees between the San Francisco and Chicago meetings  These interactions have resulted in the current bylaw change recommendations 
In Chicago, representatives from MAC attended several committee meetings and all seven councilor caucuses to summarize the current proposal for membership changes, answer questions, and seek input  In addition, all committee chairs were invited to have their respective committees review these bylaw changes and respond to MAC—if possible—before council met on Wednesday  MAC received 11 responses: eight supported the proposed changes as is, and three supported the proposed language with specified changes or considerations 
The comprehensive petition will likely represent the most significant and voluminous change in the ACS bylaws that has occurred in decades, and MAC is proud to be among the leaders in its development and in efforts to get it right the first time  Hundreds of individuals have contributed to this major effort, since MAC began such discussions at the spring 2004 national meeting 
The Committee on Ethics met in Chicago and discussed the possibility of organizing and scheduling a committee retreat in the near future to enable the committee to move from the current stage of exploring the needs and interests of ACS members to setting priorities for the next few years 
The Project SEED program offers summer research opportunities for high school students from economically disadvantaged families  Since its inception in 1968, the program has had a significant impact on the lives of more than 8,400 students  At the selection meeting in March, the committee approved research projects for 340 SEED I students and 98 SEED II students for this summer in more than 100 institutions 
The 2006 annual assessment surveys from 300 students indicate that 78% of the Project SEED participants are planning to major in a chemistry-related science, and 66% aspire to continue to graduate education  This program is made possible by contributions from industry, academia, local sections, ACS friends and members, the ACS Petroleum Research Fund, and the Project SEED Endowment 
The committee formally submitted a request to ConC to amend the Project SEED acronym and the committee duties described in the Supplementary Information of the "ACS Charter, Constitution, Bylaws & Regulations "
In Chicago, the committee's agenda focused on the ACS Strategic Plan and how Project SEED fits into it, the Program Review Advisory Group (PRAG) review of the Project SEED program, the committee's review of an online application form, and planning of the 40th anniversary celebration to be held at the Philadelphia meeting in the fall of 2008  The committee selected a task force to review the criteria for selection of the Project SEED ChemLuminary Award 
3  Making ACS relevant to technicians 
Last year, CTA, along with the Division of Chemical Technicians, the Committee on Economic & Professional Affairs, and ChemTechLinks, started the Equipping the 2015 Chemical Technology Workforce initiative  This year, the initiative awarded six $500 minigrants to activities and programs that support the educational and professional development of chemical technicians 
We are pleased to announce that the winners of the minigrants are the ACS Division of Environmental Chemistry; the Chemical Technician Program Chair for the 39th ACS Central Regional Meeting in Covington, Ky ; Delta College, University Center, Mich ; Grand Rapids Community College, in Michigan; Mount San Antonio College, Walnut, Calif ; and Southwestern College in Chula Vista, Calif 
The winners are collaborating with industry, academia, and ACS local sections on such activities as chemical technology career fairs for high school students, discussion panels on employability skills for technicians, and technical programming at regional and national meetings on the vital role technicians have in the chemical enterprise 
Because of the enthusiastic response to the minigrants, Equipping the 2015 Chemical Technology Workforce will be supporting another round of minigrants to be distributed in the fall  Details will be available on the website  For more information, go to www ChemTechLinks org and click on "Equipping the 2015 Chemical Technology Workforce "
CTA has also joined with the Joint Subcommittee on Diversity, formerly known as the Collaboration of Committees Working Group  Because this group is focused on increasing diversity in ACS and the chemical enterprise, we believe that this is an opportunity to raise awareness of the value of technicians  CTA looks forward to collaborating on the promotion of traditionally underrepresented chemical professionals 
In 2007, CTA will be placing renewed focus on distribution of the ACS Chemical Technology Student Recognition Award  The award recognizes academic excellence in students preparing for careers as chemical technicians  For more information on the award, please visit the CTA website at chemistry org/committees/cta 



ground_truth: According to the globin that is affected (alpha or beta).

prompt_front: Now, answer the following question based on the text below, only give me the answer and do not output any other words.

Question: How are smartphones and tablets different from a technical perspective?

Read the following text and answer briefly.

Context 2:  Sales are increasing now because people without tablets are buying them  When most people already own a tablet, they won't be buying a new one every year and therefore sales will stagnate/decrease The PC market is saturated and in a couple of years, the tablet market will be saturated too  Basically, in order to increase sales in a saturated market, you need to increase the population growth or decrease the longevity of the product That's true as long as most people are still buying both a tablet and a laptop when each needs to be replaced  I think the assumption is that, as you say, the tablet market will saturate, with people just replacing existing ones, but the desktop/laptop market could decrease much farther than that, if most people stop replacing them at all  I'm not sure of the likelihood of that, but I think that's where this idea comes from 
ggeezz wrote:Intel cannot abandon the phone/tablet market  Desktop/laptop sales are stagnating/decreasing and phones/tablets are on the rise  This trend is only going to increase going forward But you're right, they're going to have use their fabs that are a step or two behind the cutting the edge  But they're going to have to up their game in the tablet space to even be able to do that The upcoming Haswell chip is showing to consume 1/3 the power of IvyBridge at peak, consumes 1/20th the power at idle, all the while maintaining Identical or better performance This chip should actually compete with ARM CPUs on both power/performance and idle I am expecting a large war 
Apple once again is dictating the performance in the mobile industry  Nice to see others being able to keep the pace, as well 
paul5ra wrote:As someone who has worked in the semiconductor industry for longer than contemporary fanboys have existed, I'm getting a bit fed-up seeing many of these articles which rewrite history with analyses distorted by the lens of the contemporary Apple or Samsung fanboy The mobile industry moved to horizontal integration a long time ago  Better indicators than these odd contemporary obsessions with the relatively non-innovative Samsung and Apple where when Motorola spun out its semiconductor division as Freescale, Nokia stopped making it's own custom designs with TI and ST, and Ericsson spun out it's Ericsson Mobile Platforms division and formed ST-Ericsson with ST The true innovation in the mobile market was done a decade or more ago mainly by Moto/Nokia/Ericsson/TI/Qualcomm, and Samsung and Apple had little to do with it  Under the hood most stuff has been on a simple evolutionary path by the SoC providers since then Yeah, and most of the innovation in the automobile industry came about before Henry Ford came into the business  Doesn't change the fact that cars would probably have been an asterisk in the history books under "toys for rich people" if it weren't for him The same applies to to mobile computing for Apple, Samsung, et al 
SheldonRoss wrote:Lagrange wrote:The question for the future is how the economics will stack up when overall device costs fall significantly and there is a big downward pressure on SoC prices  In that situation, can Intel still justify bringing their A-game to a market where products are essentially commoditised and you have processors selling for a only a few dollars each?The lesson from their previous involvement in the DRAM market is that they probably won't want to be involved because there isn't enough money to be made to justify manufacturing phone SoCs on a cutting edge, or near cutting edge process  In that scenario, Intel may not totally abandon the market but they might just stick to manufacturing SoCs on nodes that are a step or two behind the state of the art I think the processing is a bigger advantage than many realize  If Intel can stay ahead in process design - which this article seems to indicate - they should have a major advantage  All else being equal a 14nm chip should be significantly faster and more efficient than the same chip at 22nm  Add in the fact that yields increase geometrically - you can fit a lot more 14nm chips on a given wafer size vs 22nm (or 32nm for the other manufacturers ) and you have a very appealing proposition  And then add in the fact that Intel actually has a pretty good graphics stack and IP  My point was that Intel might have a one or two process advantage over the rest of the industry at the cutting edge but that doesn't mean that they can afford to manufacture on those processes for very low margin parts  If the SoC market becomes increasingly commoditised, there isn't going to be the money to justify making them in a state of the art fab Remember that one of the big selling points of Itanium was that it would make use of process advantages that were effectively paid for by the mainstream x86 market  That didn't quite work out in practice and Itanium processors were often well behind Xeons in process technology 
paul5ra wrote:As someone who has worked in the semiconductor industry for longer than contemporary fanboys have existed, I'm getting a bit fed-up seeing many of these articles which rewrite history with analyses distorted by the lens of the contemporary Apple or Samsung fanboy The mobile industry moved to horizontal integration a long time ago  Better indicators than these odd contemporary obsessions with the relatively non-innovative Samsung and Apple where when Motorola spun out its semiconductor division as Freescale, Nokia stopped making it's own custom designs with TI and ST, and Ericsson spun out it's Ericsson Mobile Platforms division and formed ST-Ericsson with ST The true innovation in the mobile market was done a decade or more ago mainly by Moto/Nokia/Ericsson/TI/Qualcomm, and Samsung and Apple had little to do with it  Under the hood most stuff has been on a simple linear evolutionary path by the SoC providers since then  The phone manufacturers have then mainly been simply sticking these off-the-shelf SoCs (and their included low-level software stacks) in a box, a job made all the easier with the SoC manufacturer collaboration providing the bulk of the work for the AOSP Just goes to show that people who have worked in an industry for a long time don't always understand what that industry is doing You haven't been working in it long enough to seem to know that it was Acorn and Apple that invented the mobile ARM CPU in the first place  All those companies you've mentioned have just been working off Acorn and Apple's pioneering work  Now, Apple is back at it again, very successfully, and all the companies you mentioned that produce chips with ARM IP in them are licensing them from the company Acorn and Apple formed—ARM 
Last edited by melgross on Wed Feb 13, 2013 11:13 am
Mark Havel wrote:ggeezz wrote:Intel cannot abandon the phone/tablet market  Desktop/laptop sales are stagnating/decreasing and phones/tablets are on the rise  This trend is only going to increase going forward But you're right, they're going to have use their fabs that are a step or two behind the cutting the edge  But they're going to have to up their game in the tablet space to even be able to do that The word you're looking for is Haswell, as far as I know If tablets move into the $100-200 range, is there going to be room for Haswell?So long as there is a higher-end tablet market, then Haswell will be able to shine, but it's going to be a much more powerful and costly part than the sort of ARM based hardware that often runs tablets  If we see a race to the bottom where price is the dominant motivator behind purchases, then a high performance SoC will struggle to make its mark 
melgross wrote:paul5ra wrote:As someone who has worked in the semiconductor industry for longer than contemporary fanboys have existed, I'm getting a bit fed-up seeing many of these articles which rewrite history with analyses distorted by the lens of the contemporary Apple or Samsung fanboy The mobile industry moved to horizontal integration a long time ago  Better indicators than these odd contemporary obsessions with the relatively non-innovative Samsung and Apple where when Motorola spun out its semiconductor division as Freescale, Nokia stopped making it's own custom designs with TI and ST, and Ericsson spun out it's Ericsson Mobile Platforms division and formed ST-Ericsson with ST The true innovation in the mobile market was done a decade or more ago mainly by Moto/Nokia/Ericsson/TI/Qualcomm, and Samsung and Apple had little to do with it  Under the hood most stuff has been on a simple linear evolutionary path by the SoC providers since then  The phone manufacturers have then mainly been simply sticking these off-the-shelf SoCs (and their included low-level software stacks) in a box, a job made all the easier with the SoC manufacturer collaboration providing the bulk of the work for the AOSP Just goes to show that people who have worked in an industry for a long time don't always understand what that industry is doing You haven't been working in it long enough to seem to know that it was Acorn and Apple that invented the mobile ARM CPU in the first place  All those companies you've mentioned have just been working off Acorn and Apple's pioneering work  Now, Apple is back at it again, very successfully, and all the companies you mentioned that produce chips with ARM IP in them are licensing them from the company Acorn and Apple formed—ARM Of course I realise ARM IP has indeed been a major driving factor too (though only one if several architectures before ARM became dominant), though I see ARM's influence on the mobile industry as having nothing to do with modern day Apple and only one small piece of the puzzle  My point is that the hard electrical engineering, mathematics, DSP, semiconductor physics/chemistry, RF engineering, analogue design, CAD etc  that make modern telecommunications possible has very little to do with the fashion companies who consumers (and unfortunately much of the tech media) associate with it and give the credit (though in this respect Samsung does deserve a bit more credit for their work on NAND flash and displays)  The industry simply would not exist TODAY without the overwhelming horizontal integration that already dominates 
Quote:In the long term, mobile devices are likely to evolve similarly to the PC and favor a horizontal business model  The real advantage is one of flexibility; as costs drop and the market expands, it will be increasingly necessary for vendors like HTC to offer a wide range of phones based on radically different SoCs  You don't mention in the article that each SoC necessarily requires a bit of parallel dev work unlike the PC  In the PC world there is a standard BIOS and HW architecture that allows for pluggable designs  On a highly integrated SoC this is untrue  HTC suffers because it has to support radically different SoCs, their drivers and boot loaders, etc  Quote:While a vertically integrated company like Apple can focus and maintain leadership in a specific (and highly lucrative) niche, it would be very difficult to expand in many growing areas of the market  The differences between an iPhone 6 and a $20 feature phone are tremendous and would be very difficult for a single company to bridge It's only difficult because Apple chooses to ignore that market, not because they can't  If they can release a $99 Apple TV, they can surely cobble together a $20 feature phone if they chose to eschew 8GB of NAND, BT, WiFi, a specialized dock connector, LTE, and their specialized processors  In other words, build the equivalent of an iPod shuffle with a horrible screen and no OS to speak of 
paul5ra wrote:melgross wrote:paul5ra wrote:As someone who has worked in the semiconductor industry for longer than contemporary fanboys have existed, I'm getting a bit fed-up seeing many of these articles which rewrite history with analyses distorted by the lens of the contemporary Apple or Samsung fanboy The mobile industry moved to horizontal integration a long time ago  Better indicators than these odd contemporary obsessions with the relatively non-innovative Samsung and Apple where when Motorola spun out its semiconductor division as Freescale, Nokia stopped making it's own custom designs with TI and ST, and Ericsson spun out it's Ericsson Mobile Platforms division and formed ST-Ericsson with ST The true innovation in the mobile market was done a decade or more ago mainly by Moto/Nokia/Ericsson/TI/Qualcomm, and Samsung and Apple had little to do with it  Under the hood most stuff has been on a simple linear evolutionary path by the SoC providers since then  The phone manufacturers have then mainly been simply sticking these off-the-shelf SoCs (and their included low-level software stacks) in a box, a job made all the easier with the SoC manufacturer collaboration providing the bulk of the work for the AOSP Just goes to show that people who have worked in an industry for a long time don't always understand what that industry is doing You haven't been working in it long enough to seem to know that it was Acorn and Apple that invented the mobile ARM CPU in the first place  All those companies you've mentioned have just been working off Acorn and Apple's pioneering work  Now, Apple is back at it again, very successfully, and all the companies you mentioned that produce chips with ARM IP in them are licensing them from the company Acorn and Apple formed—ARM Of course I realise ARM IP has indeed been a major driving factor too (though only one if several architectures before ARM became dominant), though I see ARM's influence on the mobile industry as having nothing to do with modern day Apple and only one piece of the puzzle  My point is that the hard electrical engineering, mathematics, DSP, semiconductor physics/chemistry, RF engineering, analogue design,etc  that make modern telecommunications possible has very little to do with the fashion companies who consumers (and unfortunately much of the tech media) associate with it and give the credit (though in this respect Samsung does deserve a bit more credit for their work on NAND flash and displays)  The industry simply would not exist TODAY without the overwhelming horizontal integration that already dominates Yes the efforts of these companies getting cellular communications standardized were immense  And the technology matured  And then they didn't do much with it  It took some youngin's to look at the problem fresh and add the UI that make today's smartphones work  As we have all seen, the moment your technology has matured is the moment you are screwed because someone else now has the opportunity to look at it as a black box and make something new  Each of those manufacturers knew that smartphones would eventually be awesome, but none of them had the UI and software design to make a truly breakout product  Imagine if Motorola would have been smart enough to buy the Android guys instead of Google  Instead, Google bought a bunch of patents on that cellular black box to try to defend it's platform And when you think about it, which consumes more man years of engineering effort per year at this point     iterating that cellular black box or developing the OS, services and apps that power today's smartphones?
Intel had better decide that they are competing in this space "for real", or they are screwed  They've already let the Atom languish for five years, during which ARM has completely caught up in performance Just like Tim Cook said, if you don't cannibalize your own markets someone else will do it for you Whether Intel will embrace that concept in time remains to be seen  Personally, I hope they don't; if Intel transforms into a chipless Fab company (like TSMC) everyone benefits 
I still think Samsung has the advantage long term because they have both the SOC and the memory products  As mentioned in the article, TSV's (Through Silicon Via's) are going to be quite a disruption  Today, people normally stack an LPDDR2 package on top of their SOC package (POP or Package On Package)  Within the LPDDR2 package, you could have a stack of DRAM die typically with wire bonding connecting the die within the package Once you more to TSV's, you can have a LOT more connections between the SOC and its DRAM's  While this is being standardized through JEDEC (http://www jedec org/category/technolog     a/3d-ics-0), Samsung has all the pieces in house to do whatever they want  You could see a 512 bit or higher bus from the SOC to the memory  The trick is that the memory and the SOC need to line up with each other when you stack them  This gives Samsung an inherent advantage This isn't just going to impact mobile either  Take a look at that JEDEC link  It also lists High Bandwidth Memory (HBM)  This is a 1024 bit bus that provides 128GBytes/s to 256GBytes/s of bandwidth to a stack of up to 8 DRAM's  Here is your processor that includes 8-16 cores and 4GBytes of really, really, fast DRAM    No DIMMs required  How many of them do you want in your server rack?If I was Intel or Apple, I would be thinking seriously about making some investments in Micron to guarantee they make some compelling DRAM's to integrate with their SOC's and processors    otherwise Samsung is going to blow them out of the water on bandwidth 
Great_Scott wrote:Intel had better decide that they are competing in this space "for real", or they are screwed  They've already let the Atom languish for five years, during which ARM has completely caught up in performance Just like Tim Cook said, if you don't cannibalize your own markets someone else will do it for you Whether Intel will embrace that concept in time remains to be seen  Personally, I hope they don't; if Intel transforms into a chipless Fab company (like TSMC) everyone benefits It's true that Atom has stood still for too long, but honestly it's pretty amazing how Atom is still competitive with current ARM chips  The Z2760 is even 32nm vs 28nm of the latest Krait and A15 chips But that's all changing with Atom moving to the tick tock schedule this year  It wouldn't even surprise me to see Apple move to Intel chips for IOS And I don't see how Intel moving to a chipless Fab company would help everyone  It certainly wouldn't help Intel 
Mabsark wrote:ggeezz wrote:Intel cannot abandon the phone/tablet market  Desktop/laptop sales are stagnating/decreasing and phones/tablets are on the rise  This trend is only going to increase going forward But you're right, they're going to have use their fabs that are a step or two behind the cutting the edge  But they're going to have to up their game in the tablet space to even be able to do that Actually, that trend will not simply keep increasing going forward  The reason desktop/laptop sales are stagnating/decreasing is due to the fact that most people already have one and therefore don't need to buy another one  The exact same thing will happen with tablets as well  Sales are increasing now because people without tablets are buying them  When most people already own a tablet, they won't be buying a new one every year and therefore sales will stagnate/decrease The PC market is saturated and in a couple of years, the tablet market will be saturated too  Basically, in order to increase sales in a saturated market, you need to increase the population growth or decrease the longevity of the product Yes and no  I'm not sure the tablet market will saturate in a "couple of years " It may be more like 5 years  But that's a quibble Here's the real issue  Right now Apple wants you to own an iPhone AND iPad AND Macbook AND iWatch AND Apple TV  Microsoft, OTOH, is making the Surface so that you could ditch your laptop and just use a Surface  Not everyone, but some people If 5 years from now, we're in a world where a significant number of people use a Surface-type device instead of a laptop, then the PC market is going to contract significantly  Maybe some of the tablet-like devices will use moderately expensive Intel chips, but some of them are going to use cheaper chips 
GravyGraphics wrote:I still think Samsung has the advantage long term because they have both the SOC and the memory products  As mentioned in the article, TSV's (Through Silicon Via's) are going to be quite a disruption  Today, people normally stack an LPDDR2 package on top of their SOC package (POP or Package On Package)  Within the LPDDR2 package, you could have a stack of DRAM die typically with wire bonding connecting the die within the package Once you more to TSV's, you can have a LOT more connections between the SOC and its DRAM's  While this is being standardized through JEDEC (http://www jedec org/category/technolog     a/3d-ics-0), Samsung has all the pieces in house to do whatever they want  You could see a 512 bit or higher bus from the SOC to the memory  The trick is that the memory and the SOC need to line up with each other when you stack them  This gives Samsung an inherent advantage This isn't just going to impact mobile either  Take a look at that JEDEC link  It also lists High Bandwidth Memory (HBM)  This is a 1024 bit bus that provides 128GBytes/s to 256GBytes/s of bandwidth to a stack of up to 8 DRAM's  Here is your processor that includes 8-16 cores and 4GBytes of really, really, fast DRAM    No DIMMs required  How many of them do you want in your server rack?If I was Intel or Apple, I would be thinking seriously about making some investments in Micron to guarantee they make some compelling DRAM's to integrate with their SOC's and processors    otherwise Samsung is going to blow them out of the water on bandwidth Why not AMD? Last I checked they still made memory   and processors/GPUs 



ground_truth: Smartphones are more compact and power constrained.

prompt_front: Now, answer the following question based on the text below, only give me the answer and do not output any other words.

Question: How many people attend the 233rd ACS national meeting?

Read the following text and answer briefly.

Context 4: Slide the toggle according to arrow direction toopen the battery case  12 EN
Power on the Controller ❷ First Start: The Controller will start automaticallyafter removing the insulating paper  Others: Short press the Home button for 1second until the status indicator flashes blue Power on the VR Headset ❸ Long press the Power button for 2 seconds untilthe status indicator turns blue Wear Your Headset for a Comfortable Fit and View ❹ Adjust the strap dial to turn the strap so that the back of your head rests on the padding  Fine-tune thelength and position of the strap to give a clear view  * Note: You can use this product with prescription glasses or lenses insert  13 EN
Fine-tune the Top Strap ❺ Fine-tune the head strap to reduce pressure on the forehead  Interpupillary Distance (IPD) Adjustment ❻ In System Setting, go to “Setting” ► “Display” to adjust IPD, tap “+” or “-” button to slightly adjust IPDuntil the picture is clear  14 64mm Please note that inappropriate IPD setting may cause ghosting or eyestrain Accurate IPD setting helps you get a clear imaging and ease eyestrain  EN
Product Details VR Headset Status Indicator Legend Blue: Powered on with battery over 20% Yellow: Charging: Battery is less than 98% Red: Charging: Battery is less than 20% Green: Charging: Battery is more than 98% or charge complete Blue flashing: Shutting down Red flashing: Battery is less than 20% Off: Sleeping or Powered off Power Power on: Long press for 2 seconds Power off: Long press for 5 seconds Hardware reset: Long press for 10 seconds Short press to enter sleep or wake up Status Indicator Face Cushion Volume ① ② ③ ④ ⑤ ⑥ ⑦ ⑧ RGB See Through Camera Do not block during use  Top Strap Removable Strap Dial Tracking Cameras Do not block during use  ⑨ ⑩ ⑪ USB-C Interface Left/Right Speaker Proximity Sensor The system wakes upwhen the VR headset isput on, sleeps when VRheadset is taken off  ⑫ ⑬ Eye Tracking Cameras Pro version only  Do not block during use  Face Tracking Camera Pro version only  Do not block during use  15 EN
Controller Status Indicator Legend Off: Connected or Powered off Blue: Firmware updating in progress Blue flashing: Searching for connection Red and blue flashing alternately: Pairing in progress 16 Joystick Menu ③ ① ② Home Power on: Short pressPower off: Long press for 6 secondsReturn home screen: Short pressScreen recentering: Press for 1 secondStatus Indicator Grip Capture Trigger ④ ⑤ ⑥ ⑦ ⑧ ⑨ Battery Case Open: Slide down the toggle andpop up the battery case  Lock: Push the battery case to lock  Tracking Ring Do not block during use  * Note: Pass the Controller Lanyardthrough the string as shown andlock at the end of the Controller EN
Operating Instructions Headset Control Mode If the Controller is not connected, you can interact with the home screen by moving your head to directthe crosshairs over your intended selection and clicking the Volume Up/Down button on the VR Headset  Switch the pointer of the master Controller In the home screen, short press the Trigger of the corresponding Controller to switch the pointer of themaster Controller  Screen re-centering Wear the VR Headset and look straight ahead, press and hold the Home button of the Controller or VRHeadset ( or the Volume Down button of the VR Headset in head control mode) for more than 1 second tore-center the screen  Disconnect the Controller Press and hold the Home button until the status indicator turns red and the Controller vibrates Controllers will automatically shut down to save power in the following cases:When the VR Headset enters deep sleep (a while after the VR Headset is taken off)When the Controller is unpairedWhen the VR Headset is powered off Add a new Controller If you need to add a new Controller (the VR Headset can only connect one left Controller and one rightController) or reconnect with an unpaired Controller  Go to “Settings” ► “Controller”, click on “Pair” Press and hold the Home button and the Trigger of the Controller at the same time until the red and bluelights of the Controller flashing alternately, and then follow the instructions on the VR Headset screen  Sleep / Wake up Option 1 (Proximity Sensor) Take off VR Headset for automatic sleeping: wear the VR Headset for automat- ic waking up  Option 2 (POWER Button) Press the Power button of the VR Headset for manual sleeping or waking up  Hardware reset VR Headset reset If the visual in the VR Headset freezes, or the VR Headset does not respond after short press the Powerbutton, you can press the Power button of the VR Headset for more than 10 seconds to reboot the VRHeadset  Controller reset If the virtual Controller, the Home button or any buttons of the Controller doesn\'t respond, remove andreinstall the battery case to restart the Controller  The VR Headset Adjustment This device has no myopia adjustment function  The VR Headset allows wearing most standard glasseswith a frame width of less than 150mm  to install Glasses Spacer to increase the space  You can install or not according to your situation  17 EN
Install Glasses Spacer Install Nose Pad If you have glasses collision with headset lens or pressure on the bridge of nose, please follow the pictureto install Glasses Spacer to increase the space  You can install or not according to your situation  If you feel light leaking from your nose, please follow the picture to install Nose Pad to block the light You can consider having it installed at your own discretion  Disassemble the Face Cushion  Install the Glasses Spacer on the Headset  ❸ ❶ ❷ Install the Face Cushion on the Glasses Spacer  Disassemble the Face Cushion  Install the Nose Pad on the Face Cushion  ❶ ❷ Install the Face Cushion on the Headset  ❸ * Note: Disassemble the Glasses Spacer 18 EN
Replace Face Cushion The Face Cushion will have the following phenomena such as color change, surface fluff, soft texture afterlong-term use and repeated cleaning  You can replace a new Face Cushion as needed  Replace Top Strap ❶ ❷ Disassemble the Face Cushion  Pinch the metal buckle of the top strap asshown, press it down and pull it out Install the Face Cushion on  ❸ ❷ ❶ • Purchase high-quality and trending apps • Join PICO Community and explore the VR worldwith other PICO players• Manage your device with ease • Engage in diverse and interactive activities • More exciting features waiting for you 19 EN
'



ground_truth: There are 14,520 attendees, including 7,152 chemical scientists, 5,059 students, 1,283 exhibitors, 119 precollege teachers, 573 exposition visitors, and 453 guests.