prompt_front: Now, answer the following question based on the text below, only give me the answer and do not output any other words.

Question: How is electricity used in everyday life?

Read the following text and answer briefly.

Context 1: For other uses, see Electricity (disambiguation) 
"Electric" redirects here  For other uses, see Electric (disambiguation) 
Lightning is one of the most dramatic effects of electricity 
Electricity is the set of physical phenomena associated with the presence and motion of matter that has a property of electric charge  In early days, electricity was considered as being not related to magnetism  Later on, many experimental results and the development of Maxwell's equations indicated that both electricity and magnetism are from a single phenomenon: electromagnetism  Various common phenomena are related to electricity, including lightning, static electricity, electric heating, electric discharges and many others 
The presence of an electric charge, which can be either positive or negative, produces an electric field  The movement of electric charges is an electric current and produces a magnetic field 
When a charge is placed in a location with a non-zero electric field, a force will act on it  The magnitude of this force is given by Coulomb's law  Thus, if that charge were to move, the electric field would be doing work on the electric charge  Thus we can speak of electric potential at a certain point in space, which is equal to the work done by an external agent in carrying a unit of positive charge from an arbitrarily chosen reference point to that point without any acceleration and is typically measured in volts 
electronics which deals with electrical circuits that involve active electrical components such as vacuum tubes, transistors, diodes and integrated circuits, and associated passive interconnection technologies 
Electrical phenomena have been studied since antiquity, though progress in theoretical understanding remained slow until the seventeenth and eighteenth centuries  Even then, practical applications for electricity were few, and it would not be until the late nineteenth century that electrical engineers were able to put it to industrial and residential use  The rapid expansion in electrical technology at this time transformed industry and society, becoming a driving force for the Second Industrial Revolution  Electricity's extraordinary versatility means it can be put to an almost limitless set of applications which include transport, heating, lighting, communications, and computation  Electrical power is now the backbone of modern industrial society 
Long before any knowledge of electricity existed, people were aware of shocks from electric fish  Ancient Egyptian texts dating from 2750 BCE referred to these fish as the "Thunderer of the Nile", and described them as the "protectors" of all other fish  Electric fish were again reported millennia later by ancient Greek, Roman and Arabic naturalists and physicians  Several ancient writers, such as Pliny the Elder and Scribonius Largus, attested to the numbing effect of electric shocks delivered by catfish and electric rays, and knew that such shocks could travel along conducting objects  Patients suffering from ailments such as gout or headache were directed to touch electric fish in the hope that the powerful jolt might cure them  Possibly the earliest and nearest approach to the discovery of the identity of lightning, and electricity from any other source, is to be attributed to the Arabs, who before the 15th century had the Arabic word for lightning ra‘ad (رعد) applied to the electric ray 
Ancient cultures around the Mediterranean knew that certain objects, such as rods of amber, could be rubbed with cat's fur to attract light objects like feathers  Thales of Miletus made a series of observations on static electricity around 600 BCE, from which he believed that friction rendered amber magnetic, in contrast to minerals such as magnetite, which needed no rubbing  Thales was incorrect in believing the attraction was due to a magnetic effect, but later science would prove a link between magnetism and electricity  According to a controversial theory, the Parthians may have had knowledge of electroplating, based on the 1936 discovery of the Baghdad Battery, which resembles a galvanic cell, though it is uncertain whether the artifact was electrical in nature 
Benjamin Franklin conducted extensive research on electricity in the 18th century, as documented by Joseph Priestley (1767) History and Present Status of Electricity, with whom Franklin carried on extended correspondence 
Electricity would remain little more than an intellectual curiosity for millennia until 1600, when the English scientist William Gilbert wrote De Magnete, in which he made a careful study of electricity and magnetism, distinguishing the lodestone effect from static electricity produced by rubbing amber  He coined the New Latin word electricus ("of amber" or "like amber", from ἤλεκτρον, elektron, the Greek word for "amber") to refer to the property of attracting small objects after being rubbed  This association gave rise to the English words "electric" and "electricity", which made their first appearance in print in Thomas Browne's Pseudodoxia Epidemica of 1646 
Further work was conducted in the 17th and early 18th centuries by Otto von Guericke, Robert Boyle, Stephen Gray and C  F  du Fay  Later in the 18th century, Benjamin Franklin conducted extensive research in electricity, selling his possessions to fund his work  In June 1752 he is reputed to have attached a metal key to the bottom of a dampened kite string and flown the kite in a storm-threatened sky  A succession of sparks jumping from the key to the back of his hand showed that lightning was indeed electrical in nature  He also explained the apparently paradoxical behavior of the Leyden jar as a device for storing large amounts of electrical charge in terms of electricity consisting of both positive and negative charges 
In 1791, Luigi Galvani published his discovery of bioelectromagnetics, demonstrating that electricity was the medium by which neurons passed signals to the muscles  Alessandro Volta's battery, or voltaic pile, of 1800, made from alternating layers of zinc and copper, provided scientists with a more reliable source of electrical energy than the electrostatic machines previously used  The recognition of electromagnetism, the unity of electric and magnetic phenomena, is due to Hans Christian Ørsted and André-Marie Ampère in 1819–1820  Michael Faraday invented the electric motor in 1821, and Georg Ohm mathematically analysed the electrical circuit in 1827  Electricity and magnetism (and light) were definitively linked by James Clerk Maxwell, in particular in his "On Physical Lines of Force" in 1861 and 1862 
While the early 19th century had seen rapid progress in electrical science, the late 19th century would see the greatest progress in electrical engineering  Through such people as Alexander Graham Bell, Ottó Bláthy, Thomas Edison, Galileo Ferraris, Oliver Heaviside, Ányos Jedlik, William Thomson, 1st Baron Kelvin, Charles Algernon Parsons, Werner von Siemens, Joseph Swan, Reginald Fessenden, Nikola Tesla and George Westinghouse, electricity turned from a scientific curiosity into an essential tool for modern life 
In 1887, Heinrich Hertz:843–44 discovered that electrodes illuminated with ultraviolet light create electric sparks more easily  In 1905, Albert Einstein published a paper that explained experimental data from the photoelectric effect as being the result of light energy being carried in discrete quantized packets, energising electrons  This discovery led to the quantum revolution  Einstein was awarded the Nobel Prize in Physics in 1921 for "his discovery of the law of the photoelectric effect"  The photoelectric effect is also employed in photocells such as can be found in solar panels and this is frequently used to make electricity commercially 
The first solid-state device was the "cat's-whisker detector" first used in the 1900s in radio receivers  A whisker-like wire is placed lightly in contact with a solid crystal (such as a germanium crystal) to detect a radio signal by the contact junction effect  In a solid-state component, the current is confined to solid elements and compounds engineered specifically to switch and amplify it  Current flow can be understood in two forms: as negatively charged electrons, and as positively charged electron deficiencies called holes  These charges and holes are understood in terms of quantum physics  The building material is most often a crystalline semiconductor 
The solid-state device came into its own with the invention of the transistor in 1947  Common solid-state devices include transistors, microprocessor chips, and RAM  A specialized type of RAM called flash RAM is used in USB flash drives and more recently, solid-state drives to replace mechanically rotating magnetic disc hard disk drives  Solid state devices became prevalent in the 1950s and the 1960s, during the transition from vacuum tubes to semiconductor diodes, transistors, integrated circuit (IC) and the light-emitting diode (LED) 
The presence of charge gives rise to an electrostatic force: charges exert a force on each other, an effect that was known, though not understood, in antiquity :457 A lightweight ball suspended from a string can be charged by touching it with a glass rod that has itself been charged by rubbing with a cloth  If a similar ball is charged by the same glass rod, it is found to repel the first: the charge acts to force the two balls apart  Two balls that are charged with a rubbed amber rod also repel each other  However, if one ball is charged by the glass rod, and the other by an amber rod, the two balls are found to attract each other  These phenomena were investigated in the late eighteenth century by Charles-Augustin de Coulomb, who deduced that charge manifests itself in two opposing forms  This discovery led to the well-known axiom: like-charged objects repel and opposite-charged objects attract 
The force acts on the charged particles themselves, hence charge has a tendency to spread itself as evenly as possible over a conducting surface  The magnitude of the electromagnetic force, whether attractive or repulsive, is given by Coulomb's law, which relates the force to the product of the charges and has an inverse-square relation to the distance between them :35 The electromagnetic force is very strong, second only in strength to the strong interaction, but unlike that force it operates over all distances  In comparison with the much weaker gravitational force, the electromagnetic force pushing two electrons apart is 1042 times that of the gravitational attraction pulling them together 
Study has shown that the origin of charge is from certain types of subatomic particles which have the property of electric charge  Electric charge gives rise to and interacts with the electromagnetic force, one of the four fundamental forces of nature  The most familiar carriers of electrical charge are the electron and proton  Experiment has shown charge to be a conserved quantity, that is, the net charge within an electrically isolated system will always remain constant regardless of any changes taking place within that system  Within the system, charge may be transferred between bodies, either by direct contact, or by passing along a conducting material, such as a wire :2–5 The informal term static electricity refers to the net presence (or 'imbalance') of charge on a body, usually caused when dissimilar materials are rubbed together, transferring charge from one to the other 
The charge on electrons and protons is opposite in sign, hence an amount of charge may be expressed as being either negative or positive  By convention, the charge carried by electrons is deemed negative, and that by protons positive, a custom that originated with the work of Benjamin Franklin  The amount of charge is usually given the symbol Q and expressed in coulombs; each electron carries the same charge of approximately −1 6022×10−19 coulomb  The proton has a charge that is equal and opposite, and thus +1 6022×10−19 coulomb  Charge is possessed not just by matter, but also by antimatter, each antiparticle bearing an equal and opposite charge to its corresponding particle 
The movement of electric charge is known as an electric current, the intensity of which is usually measured in amperes  Current can consist of any moving charged particles; most commonly these are electrons, but any charge in motion constitutes a current  Electric current can flow through some things, electrical conductors, but will not flow through an electrical insulator 
By historical convention, a positive current is defined as having the same direction of flow as any positive charge it contains, or to flow from the most positive part of a circuit to the most negative part  Current defined in this manner is called conventional current  The motion of negatively charged electrons around an electric circuit, one of the most familiar forms of current, is thus deemed positive in the opposite direction to that of the electrons  However, depending on the conditions, an electric current can consist of a flow of charged particles in either direction, or even in both directions at once  The positive-to-negative convention is widely used to simplify this situation 
The process by which electric current passes through a material is termed electrical conduction, and its nature varies with that of the charged particles and the material through which they are travelling  Examples of electric currents include metallic conduction, where electrons flow through a conductor such as metal, and electrolysis, where ions (charged atoms) flow through liquids, or through plasmas such as electrical sparks  While the particles themselves can move quite slowly, sometimes with an average drift velocity only fractions of a millimetre per second,:17 the electric field that drives them itself propagates at close to the speed of light, enabling electrical signals to pass rapidly along wires 
Current causes several observable effects, which historically were the means of recognising its presence  That water could be decomposed by the current from a voltaic pile was discovered by Nicholson and Carlisle in 1800, a process now known as electrolysis  Their work was greatly expanded upon by Michael Faraday in 1833  Current through a resistance causes localised heating, an effect James Prescott Joule studied mathematically in 1840 :23–24 One of the most important discoveries relating to current was made accidentally by Hans Christian Ørsted in 1820, when, while preparing a lecture, he witnessed the current in a wire disturbing the needle of a magnetic compass  He had discovered electromagnetism, a fundamental interaction between electricity and magnetics  The level of electromagnetic emissions generated by electric arcing is high enough to produce electromagnetic interference, which can be detrimental to the workings of adjacent equipment 
In engineering or household applications, current is often described as being either direct current (DC) or alternating current (AC)  These terms refer to how the current varies in time  Direct current, as produced by example from a battery and required by most electronic devices, is a unidirectional flow from the positive part of a circuit to the negative :11 If, as is most common, this flow is carried by electrons, they will be travelling in the opposite direction  Alternating current is any current that reverses direction repeatedly; almost always this takes the form of a sine wave :206–07 Alternating current thus pulses back and forth within a conductor without the charge moving any net distance over time  The time-averaged value of an alternating current is zero, but it delivers energy in first one direction, and then the reverse  Alternating current is affected by electrical properties that are not observed under steady state direct current, such as inductance and capacitance :223–25 These properties however can become important when circuitry is subjected to transients, such as when first energised 
The concept of the electric field was introduced by Michael Faraday  An electric field is created by a charged body in the space that surrounds it, and results in a force exerted on any other charges placed within the field  The electric field acts between two charges in a similar manner to the way that the gravitational field acts between two masses, and like it, extends towards infinity and shows an inverse square relationship with distance  However, there is an important difference  Gravity always acts in attraction, drawing two masses together, while the electric field can result in either attraction or repulsion  Since large bodies such as planets generally carry no net charge, the electric field at a distance is usually zero  Thus gravity is the dominant force at distance in the universe, despite being much weaker 
A hollow conducting body carries all its charge on its outer surface  The field is therefore zero at all places inside the body :88 This is the operating principal of the Faraday cage, a conducting metal shell which isolates its interior from outside electrical effects 
The principles of electrostatics are important when designing items of high-voltage equipment  There is a finite limit to the electric field strength that may be withstood by any medium  Beyond this point, electrical breakdown occurs and an electric arc causes flashover between the charged parts  Air, for example, tends to arc across small gaps at electric field strengths which exceed 30 kV per centimetre  Over larger gaps, its breakdown strength is weaker, perhaps 1 kV per centimetre  The most visible natural occurrence of this is lightning, caused when charge becomes separated in the clouds by rising columns of air, and raises the electric field in the air to greater than it can withstand  The voltage of a large lightning cloud may be as high as 100 MV and have discharge energies as great as 250 kWh 
A pair of AA cells  The + sign indicates the polarity of the potential difference between the battery terminals 
The concept of electric potential is closely linked to that of the electric field  A small charge placed within an electric field experiences a force, and to have brought that charge to that point against the force requires work  The electric potential at any point is defined as the energy required to bring a unit test charge from an infinite distance slowly to that point  It is usually measured in volts, and one volt is the potential for which one joule of work must be expended to bring a charge of one coulomb from infinity :494–98 This definition of potential, while formal, has little practical application, and a more useful concept is that of electric potential difference, and is the energy required to move a unit charge between two specified points  An electric field has the special property that it is conservative, which means that the path taken by the test charge is irrelevant: all paths between two specified points expend the same energy, and thus a unique value for potential difference may be stated :494–98 The volt is so strongly identified as the unit of choice for measurement and description of electric potential difference that the term voltage sees greater everyday usage 
For practical purposes, it is useful to define a common reference point to which potentials may be expressed and compared  While this could be at infinity, a much more useful reference is the Earth itself, which is assumed to be at the same potential everywhere  This reference point naturally takes the name earth or ground  Earth is assumed to be an infinite source of equal amounts of positive and negative charge, and is therefore electrically uncharged—and unchargeable 
Electric potential is a scalar quantity, that is, it has only magnitude and not direction  It may be viewed as analogous to height: just as a released object will fall through a difference in heights caused by a gravitational field, so a charge will 'fall' across the voltage caused by an electric field  As relief maps show contour lines marking points of equal height, a set of lines marking points of equal potential (known as equipotentials) may be drawn around an electrostatically charged object  The equipotentials cross all lines of force at right angles  They must also lie parallel to a conductor's surface, otherwise this would produce a force that will move the charge carriers to even the potential of the surface 
Ørsted's discovery in 1821 that a magnetic field existed around all sides of a wire carrying an electric current indicated that there was a direct relationship between electricity and magnetism  Moreover, the interaction seemed different from gravitational and electrostatic forces, the two forces of nature then known  The force on the compass needle did not direct it to or away from the current-carrying wire, but acted at right angles to it  Ørsted's slightly obscure words were that "the electric conflict acts in a revolving manner " The force also depended on the direction of the current, for if the flow was reversed, then the force did too 
Ørsted did not fully understand his discovery, but he observed the effect was reciprocal: a current exerts a force on a magnet, and a magnetic field exerts a force on a current  The phenomenon was further investigated by Ampère, who discovered that two parallel current-carrying wires exerted a force upon each other: two wires conducting currents in the same direction are attracted to each other, while wires containing currents in opposite directions are forced apart  The interaction is mediated by the magnetic field each current produces and forms the basis for the international definition of the ampere 
This relationship between magnetic fields and currents is extremely important, for it led to Michael Faraday's invention of the electric motor in 1821  Faraday's homopolar motor consisted of a permanent magnet sitting in a pool of mercury  A current was allowed through a wire suspended from a pivot above the magnet and dipped into the mercury  The magnet exerted a tangential force on the wire, making it circle around the magnet for as long as the current was maintained 
Experimentation by Faraday in 1831 revealed that a wire moving perpendicular to a magnetic field developed a potential difference between its ends  Further analysis of this process, known as electromagnetic induction, enabled him to state the principle, now known as Faraday's law of induction, that the potential difference induced in a closed circuit is proportional to the rate of change of magnetic flux through the loop  Exploitation of this discovery enabled him to invent the first electrical generator in 1831, in which he converted the mechanical energy of a rotating copper disc to electrical energy  Faraday's disc was inefficient and of no use as a practical generator, but it showed the possibility of generating electric power using magnetism, a possibility that would be taken up by those that followed on from his work 
Italian physicist Alessandro Volta showing his "battery" to French emperor Napoleon Bonaparte in the early 19th century 
The ability of chemical reactions to produce electricity, and conversely the ability of electricity to drive chemical reactions has a wide array of uses 
Electrochemistry has always been an important part of electricity  From the initial invention of the Voltaic pile, electrochemical cells have evolved into the many different types of batteries, electroplating and electrolysis cells  Aluminium is produced in vast quantities this way, and many portable devices are electrically powered using rechargeable cells 
A basic electric circuit  The voltage source V on the left drives a current I around the circuit, delivering electrical energy into the resistor R  From the resistor, the current returns to the source, completing the circuit 
An electric circuit is an interconnection of electric components such that electric charge is made to flow along a closed path (a circuit), usually to perform some useful task 
Electric power is the rate at which electric energy is transferred by an electric circuit  The SI unit of power is the watt, one joule per second 
Electricity generation is often done with electric generators, but can also be supplied by chemical sources such as electric batteries or by other means from a wide variety of sources of energy  Electric power is generally supplied to businesses and homes by the electric power industry  Electricity is usually sold by the kilowatt hour (3 6 MJ) which is the product of power in kilowatts multiplied by running time in hours  Electric utilities measure power using electricity meters, which keep a running total of the electric energy delivered to a customer  Unlike fossil fuels, electricity is a low entropy form of energy and can be converted into motion or many other forms of energy with high efficiency 
Electronics deals with electrical circuits that involve active electrical components such as vacuum tubes, transistors, diodes, optoelectronics, sensors and integrated circuits, and associated passive interconnection technologies  The nonlinear behaviour of active components and their ability to control electron flows makes amplification of weak signals possible and electronics is widely used in information processing, telecommunications, and signal processing  The ability of electronic devices to act as switches makes digital information processing possible  Interconnection technologies such as circuit boards, electronics packaging technology, and other varied forms of communication infrastructure complete circuit functionality and transform the mixed components into a regular working system 
Today, most electronic devices use semiconductor components to perform electron control  The study of semiconductor devices and related technology is considered a branch of solid state physics, whereas the design and construction of electronic circuits to solve practical problems come under electronics engineering 
Thus, the work of many researchers enabled the use of electronics to convert signals into high frequency oscillating currents, and via suitably shaped conductors, electricity permits the transmission and reception of these signals via radio waves over very long distances 
Early 20th-century alternator made in Budapest, Hungary, in the power generating hall of a hydroelectric station (photograph by Prokudin-Gorsky, 1905–1915) 
In the 6th century BC, the Greek philosopher Thales of Miletus experimented with amber rods and these experiments were the first studies into the production of electrical energy  While this method, now known as the triboelectric effect, can lift light objects and generate sparks, it is extremely inefficient  It was not until the invention of the voltaic pile in the eighteenth century that a viable source of electricity became available  The voltaic pile, and its modern descendant, the electrical battery, store energy chemically and make it available on demand in the form of electrical energy  The battery is a versatile and very common power source which is ideally suited to many applications, but its energy storage is finite, and once discharged it must be disposed of or recharged  For large electrical demands electrical energy must be generated and transmitted continuously over conductive transmission lines 
Electrical power is usually generated by electro-mechanical generators driven by steam produced from fossil fuel combustion, or the heat released from nuclear reactions; or from other sources such as kinetic energy extracted from wind or flowing water  The modern steam turbine invented by Sir Charles Parsons in 1884 today generates about 80 percent of the electric power in the world using a variety of heat sources  Such generators bear no resemblance to Faraday's homopolar disc generator of 1831, but they still rely on his electromagnetic principle that a conductor linking a changing magnetic field induces a potential difference across its ends  The invention in the late nineteenth century of the transformer meant that electrical power could be transmitted more efficiently at a higher voltage but lower current  Efficient electrical transmission meant in turn that electricity could be generated at centralised power stations, where it benefited from economies of scale, and then be despatched relatively long distances to where it was needed 
Since electrical energy cannot easily be stored in quantities large enough to meet demands on a national scale, at all times exactly as much must be produced as is required  This requires electricity utilities to make careful predictions of their electrical loads, and maintain constant co-ordination with their power stations  A certain amount of generation must always be held in reserve to cushion an electrical grid against inevitable disturbances and losses 
Electricity is a very convenient way to transfer energy, and it has been adapted to a huge, and growing, number of uses  The invention of a practical incandescent light bulb in the 1870s led to lighting becoming one of the first publicly available applications of electrical power  Although electrification brought with it its own dangers, replacing the naked flames of gas lighting greatly reduced fire hazards within homes and factories  Public utilities were set up in many cities targeting the burgeoning market for electrical lighting  In the late 20th century and in modern times, the trend has started to flow in the direction of deregulation in the electrical power sector 
The resistive Joule heating effect employed in filament light bulbs also sees more direct use in electric heating  While this is versatile and controllable, it can be seen as wasteful, since most electrical generation has already required the production of heat at a power station  A number of countries, such as Denmark, have issued legislation restricting or banning the use of resistive electric heating in new buildings  Electricity is however still a highly practical energy source for heating and refrigeration, with air conditioning/heat pumps representing a growing sector for electricity demand for heating and cooling, the effects of which electricity utilities are increasingly obliged to accommodate 
Electricity is used within telecommunications, and indeed the electrical telegraph, demonstrated commercially in 1837 by Cooke and Wheatstone, was one of its earliest applications  With the construction of first intercontinental, and then transatlantic, telegraph systems in the 1860s, electricity had enabled communications in minutes across the globe  Optical fibre and satellite communication have taken a share of the market for communications systems, but electricity can be expected to remain an essential part of the process 
The effects of electromagnetism are most visibly employed in the electric motor, which provides a clean and efficient means of motive power  A stationary motor such as a winch is easily provided with a supply of power, but a motor that moves with its application, such as an electric vehicle, is obliged to either carry along a power source such as a battery, or to collect current from a sliding contact such as a pantograph  Electrically powered vehicles are used in public transportation, such as electric buses and trains, and an increasing number of battery-powered electric cars in private ownership 
Electronic devices make use of the transistor, perhaps one of the most important inventions of the twentieth century, and a fundamental building block of all modern circuitry  A modern integrated circuit may contain several billion miniaturised transistors in a region only a few centimetres square 
A voltage applied to a human body causes an electric current through the tissues, and although the relationship is non-linear, the greater the voltage, the greater the current  The threshold for perception varies with the supply frequency and with the path of the current, but is about 0 1 mA to 1 mA for mains-frequency electricity, though a current as low as a microamp can be detected as an electrovibration effect under certain conditions  If the current is sufficiently high, it will cause muscle contraction, fibrillation of the heart, and tissue burns  The lack of any visible sign that a conductor is electrified makes electricity a particular hazard  The pain caused by an electric shock can be intense, leading electricity at times to be employed as a method of torture  Death caused by an electric shock is referred to as electrocution  Electrocution is still the means of judicial execution in some jurisdictions, though its use has become rarer in recent times 
Electricity is not a human invention, and may be observed in several forms in nature, a prominent manifestation of which is lightning  Many interactions familiar at the macroscopic level, such as touch, friction or chemical bonding, are due to interactions between electric fields on the atomic scale  The Earth's magnetic field is thought to arise from a natural dynamo of circulating currents in the planet's core  Certain crystals, such as quartz, or even sugar, generate a potential difference across their faces when subjected to external pressure  This phenomenon is known as piezoelectricity, from the Greek piezein (πιέζειν), meaning to press, and was discovered in 1880 by Pierre and Jacques Curie  The effect is reciprocal, and when a piezoelectric material is subjected to an electric field, a small change in physical dimensions takes place 
§Bioelectrogenesis in microbial life is a prominent phenomenon in soils and sediment ecology resulting from anaerobic respiration  The microbial fuel cell mimics this ubiquitous natural phenomenon 
Some organisms, such as sharks, are able to detect and respond to changes in electric fields, an ability known as electroreception, while others, termed electrogenic, are able to generate voltages themselves to serve as a predatory or defensive weapon  The order Gymnotiformes, of which the best known example is the electric eel, detect or stun their prey via high voltages generated from modified muscle cells called electrocytes  All animals transmit information along their cell membranes with voltage pulses called action potentials, whose functions include communication by the nervous system between neurons and muscles  An electric shock stimulates this system, and causes muscles to contract  Action potentials are also responsible for coordinating activities in certain plants 
In the 19th and early 20th century, electricity was not part of the everyday life of many people, even in the industrialised Western world  The popular culture of the time accordingly often depicted it as a mysterious, quasi-magical force that can slay the living, revive the dead or otherwise bend the laws of nature  This attitude began with the 1771 experiments of Luigi Galvani in which the legs of dead frogs were shown to twitch on application of animal electricity  "Revitalization" or resuscitation of apparently dead or drowned persons was reported in the medical literature shortly after Galvani's work  These results were known to Mary Shelley when she authored Frankenstein (1819), although she does not name the method of revitalization of the monster  The revitalization of monsters with electricity later became a stock theme in horror films 
As the public familiarity with electricity as the lifeblood of the Second Industrial Revolution grew, its wielders were more often cast in a positive light, such as the workers who "finger death at their gloves' end as they piece and repiece the living wires" in Rudyard Kipling's 1907 poem Sons of Martha  Electrically powered vehicles of every sort featured large in adventure stories such as those of Jules Verne and the Tom Swift books  The masters of electricity, whether fictional or real—including scientists such as Thomas Edison, Charles Steinmetz or Nikola Tesla—were popularly conceived of as having wizard-like powers 
With electricity ceasing to be a novelty and becoming a necessity of everyday life in the later half of the 20th century, it required particular attention by popular culture only when it stops flowing, an event that usually signals disaster  The people who keep it flowing, such as the nameless hero of Jimmy Webb’s song "Wichita Lineman" (1968), are still often cast as heroic, wizard-like figures 
Ampère's circuital law, connects the direction of an electric current and its associated magnetic currents 
^ Diogenes Laertius  R D  Hicks (ed )  "Lives of Eminent Philosophers, Book 1 Chapter 1 "  Perseus Digital Library  Tufts University  Retrieved 5 February 2017  Aristotle and Hippias affirm that, arguing from the magnet and from amber, he attributed a soul or life even to inanimate objects 
^ Aristotle  Daniel C  Stevenson (ed )  "De Animus (On the Soul) Book 1 Part 2 (B4 verso)"  The Internet Classics Archive  Translated by J A  Smith  Retrieved 5 February 2017  Thales, too, to judge from what is recorded about him, seems to have held soul to be a motive force, since he said that the magnet has a soul in it because it moves the iron 
^ a b c Guarnieri, M  (2014)  "Electricity in the age of Enlightenment"  IEEE Industrial Electronics Magazine  8 (3): 60–63  doi:10 1109/MIE 2014 2335431 
^ Srodes, James (2002), Franklin: The Essential Founding Father, Regnery Publishing, pp  92–94, ISBN 0-89526-163-4 It is uncertain if Franklin personally carried out this experiment, but it is popularly attributed to him 
^ a b Guarnieri, M  (2014)  "The Big Jump from the Legs of a Frog"  IEEE Industrial Electronics Magazine  8 (4): 59–61, 69  doi:10 1109/MIE 2014 2361237 
^ Hertz, Heinrich (1887)  "Ueber den Einfluss des ultravioletten Lichtes auf die electrische Entladung"  Annalen der Physik  267 (8): S  983–1000  Bibcode:1887AnP   267  983H  doi:10 1002/andp 18872670827 
^ "The Nobel Prize in Physics 1921"  Nobel Foundation  Retrieved 2013-03-16 
^ John Sydney Blakemore, Solid state physics, pp  1–3, Cambridge University Press, 1985 ISBN 0-521-31391-0 
^ Richard C  Jaeger, Travis N  Blalock, Microelectronic circuit design, pp  46–47, McGraw-Hill Professional, 2003 ISBN 0-07-250503-6 
^ "The repulsive force between two small spheres charged with the same type of electricity is inversely proportional to the square of the distance between the centres of the two spheres " Charles-Augustin de Coulomb, Histoire de l'Academie Royal des Sciences, Paris 1785 
^ Sewell, Tyson (1902), The Elements of Electrical Engineering, Lockwood, p  18   The Q originally stood for 'quantity of electricity', the term 'electricity' now more commonly expressed as 'charge' 
^ a b Berkson, William (1974), Fields of Force: The Development of a World View from Faraday to Einstein, Routledge, p  370, ISBN 0-7100-7626-6 Accounts differ as to whether this was before, during, or after a lecture 
^ "Lab Note #105 EMI Reduction – Unsuppressed vs  Suppressed"  Arc Suppression Technologies  April 2011  Retrieved March 7, 2012 
^ Almost all electric fields vary in space  An exception is the electric field surrounding a planar conductor of infinite extent, the field of which is uniform 
^ Paul J  Nahin (9 October 2002)  Oliver Heaviside: The Life, Work, and Times of an Electrical Genius of the Victorian Age  JHU Press  ISBN 978-0-8018-6909-9 
^ "The Bumpy Road to Energy Deregulation"  EnPowered  2016-03-28 
^ a b c d e f g h Van Riper, op cit , p  71 
Look up electricity in Wiktionary, the free dictionary 
Basic Concepts of Electricity chapter from Lessons In Electric Circuits Vol 1 DC book and series 
Context 2: \section{Introduction}
Cognitive deficit of older adults is one of the biggest global public health challenges in elderly care  Approximately 5 2 million people of 65 and older are suffered with any form of cognitive impairments in United States in 2012 \cite{stat12}  Dementia is one of the major causes of the cognitive impairments which is more acute among 85 and older population (50\%) \cite{stat12}  However, the costs (financial and time) of health care and long-term care for individuals with Alzheimer's (special form of dementia) or other dementias are substantial  For example, during 2016, about 15 9 million family and friends in United States provided 18 2 billion hours of unpaid assistance to those with cognitive impairments which is a contribution to the nation valued at \$230 1 billion  One the other hand, total payments for all individuals with all form of cognitive impairments are estimated at \$259 billion  Total annual payments for health care, long-term care and hospice care for people with Alzheimer's or other dementias are projected to increase from \$259 billion in 2017 to more than \$1 1 trillion in 2050  Among the above costs, a significant amount are relevant to clinical and diagnostic tests \cite{stat17}  Although clinical and diagnostic tests have become more precise in identifying dementia, studies have shown that there is a high degree of underrecognition especially in early detection  However, there are many advantages to obtaining an early and accurate diagnosis when cognitive symptoms are first noticed as the root cause findings of impairment always lessen the progress of impairment status and sometimes symptoms can be reversible and cured 

With the proliferation of emerging ubiquitous computing technologies, many mobile and wearable devices have been available to capture continuous functional and physiological behavior of older adults  Wearable sensors are now capable of estimating number of steps being taken, physical activity levels, sleep patterns and physiological outcomes (heart rate, skin conductance) of older adults \cite{sano15}  Ambient sensors also help capture the movement patterns of objects and humans for activity and behavior recognition \cite{dawadi14,dawadi15}  Researchers also proved the existence of correlations between cognitive impairment and everyday task performance \cite{dawadi14, akl15,alam16} as well as physiological symptoms \cite{alam16,sano15}  Although current studies showed some successes in IoT-assisted cognitive health assessment in different domains individually, there are several existing challenges in developing and validating a fully automated multi-modal assessment model 

\begin{enumerate}
\item \emph{Real-time IoT System}: A real-time IoT system must include a continuous and fault tolerant data streaming capability among central hub, wearable sensors and ambient sensors regardless of network communication protocol (WiFi, Ethernet, Bluetooth etc ) which are not available in existing researches 
\item \emph{Multi-modal Context Fusion}: Though several offline clinically validated cognitive health assessment tools exist \cite{wai03, starling99, krapp07, yesavage82, zung71}, there is no universally accepted method for IoT-assisted automatic cognitive health assessment in smart home environment that can fuse multi-modal sensor contexts altogether  For example, some researchers showed ambient sensors based Activities of Daily Livigin (ADLs) sequence pattern can signify the cognitive health status of older adults \cite{akl15, dawadi15}  Researchers also showed wearable Electrodermal Activity pattern analysis may carry the significance of cognitive status \cite{sano15}  However, for validation of IoT based cognitive health assessment, self-reported surveys, clinical diagnosis and observation based tools are used individually by prior researchers \cite{akl15, dawadi15, sano15, alam16} 
\end{enumerate}

Regarding aforementioned challenges for the automation of cognitive health assessment, \emph{AutoCogniSys} considers (i) reproducibility of our model in any smart home system consists of ambient motion sensors, wearable accelerometer (ACC) sensors, wearable Electrodermal Activity (EDA) and Photoplethysmography (PPG) sensors individually or combined streams; (ii) context awareness based on ambient motion sensors and wearable ACC sensors in any types of activities such as hand gestural, postural and complex ADLs; and (iii) high accuracy, i e , a recall rate of over 90\% with less than 5\% false positive rate  More specifically, \emph{AutoCogniSys} extends our existing work \cite{alam16} in three dimensions,

\emph{(1) True Automation:} We first investigate the correlations of cognitive impairment with human activities and stress where we manually labeled activities, extract the corresponding physiological sensor (EDA and PPG) features of each activity, and use statistical method to find correlations  Then, we propose automatic complex activity recognition based on a Hierarchical Dynamic Bayesian Network (HDBN) model, fine-grained extraction of physiological sensor features and finally machine learning classification of cognitive impairment 

\emph{(2) Noises Elimination:} We define different types of noises on ACC, EDA and PPG sensors, propose extensive signal processing techniques to remove noises and show significant improvement can be achieved in cognitive impairment classification 

\emph{(3) Implementation and Evaluation:} Finally, we design and implement IoT system and analytic methods and minimize the human involvement to automate our proposed cognitive health assessment approach by considering effective smart home sensor customization and deployment, data collection, screening, cleaning and filtering, feature computation, normalization and classification, and activity  model training 

\textbf{Research Questions:} \emph{AutoCogniSys} consequently tackles the following key research questions 

$\bullet$ Can we detect simultaneously the periodic rhythms of  both hand gestures and postural activities from wrist-worn ACC sensor signal for diverse population (population with same activity but diverse ways such as walking with walker, stretcher or normally)? If so, how can we incorporate the hand gesture, posture and ambient sensor data streams to help improve the ADLs recognition models?

$\bullet$ How can we exploit and relate the micro-activity features into noise free physiological sensor signals processing to automate cognitive health assessment process? What are the critical roles of clinical survey and technology guided assessment methodologies and their inter-relationships for automating the different intermediate steps of cognitive health assessment process?

To tackle these, we make the following \textbf{key contributions}:

$\bullet$ We employ an extensive signal deconvolution technique that in conjunction with machine learning technique helps facilitate a wrist-worn ACC-based multi-label (hand gestural and postural) activity recognition for diverse population  We then leverage multi-label context sets with ambient and object sensor signals for complex activity recognition based on HDBN model 

$\bullet$ We propose a novel collaborative filter for EDA signal processing by postulating signal as a mixture of three components: \emph{tonic phase, phasic phase} and \emph{motion artifacts}, and employ convex optimization technique for filtering out the motion artifacts  We also propose a novel PPG signal processing technique to filter out the inherent motion artifacts and noises using improved Periodic Moving Average Filtering (PMAF) technique 

$\bullet$  We design and prototype an IoT system consisting of multiple devices (wearable wrist band, IP camera, object and ambient sensors) connected with central hub via WiFi, Ethernet and Bluetooth communication protocols  We collected data from 22 older adults living in a continuing care retirement community center in a very natural setting (IRB \#HP-00064387) 

$\bullet$ Finally, we employ statistical and machine learning techniques to jointly correlate the activity performance metrics and stress (EDA and PPG) features that helps achieve max  93\% of cognitive impairment status detection accuracy  We evaluate \emph{AutoCogniSys} on 5 clinically validated offline assessment tools as ground truth 
\section{Related Works}
\emph{AutoCogniSys} builds on previous works on wearable devices based low-level (postural and hand gestural) activity recognition and their integration with ambient sensors to recognize complex ADLs, the underlying signal processing and applications on cognitive health assessment automation 
\subsection{Wearable Sensor Signal Processing}
Wearable sensors can be two types: physical and physiological  Physical sensors (accelerometer, gyroscope etc ) signal values change over the movements of the sensor devices  Physiological sensors change over physiological condition of body such as EDA changes over stress and PPG changes over heart rate  However, physical movements also impose noises on physiological sensor signals which is called \emph{motion artifacts} 
\subsubsection{Physiological Signal Processing}
A continuous and descrete decomposition of EDA, and time and frequency domain analytics of PPG signal have been investigated before to extract relevant physiological features which were contaminated with noises and motion artifacts \cite{alam16}  \cite{setz10} denoised and classified EDA from cognitive load and stress with accuracy higher than 80\%  Though motion artifacts removal techniques such as exponential smoothing \cite{hern11} and low-pass filters \cite{poh10, hernandez14} provide significant improvement in filtering EDA signals, wavelet transforms offer more sophisticated refinement for any kind of physiological sensors such as electroencephalogram \cite{krish06, zikov02}, electrocardiogram \cite{erc06,alfa08}, and PPG \cite{lee03}  \cite{chen15} proposed a stationary wavelet transform (SWT) based motion artifacts removal technique  `cvxEDA' proposed  a convex optimization technique considering EDA as a mixture of white gaussian noise, tonic and phasic components where white gaussian noise includes motion artifacts and external noises \cite{greco16}  \emph{AutoCogniSys} intelligently combines SWT and `cvxEDA' together to remove noises and motion artifacts from EDA signal  On the other hand, it is more difficult to remove motion artifacts from PPG signal due to its periodicity of nature \cite{wang13}  Researchers proposed different methods such as frequency analytics \cite{garde13,wang13}, statistical analytics \cite{peng14} and digital filter \cite{lee10} to reduce noises and motion artifacts from PPG  \emph{AutoCogniSys} used Periodic Moving Average Filter (PMAF) in this regard \cite{lee07} 
\subsubsection{Physical Sensor Signal Processing}
ACC based hand gesture recognition has been explored by several researchers in past such as discrete hidden markov model \cite{liu10}, artificial neural network \cite{arce11}, weighted naive bayes and dynamic time warping \cite{mace13}  Akl et  al  proposed 18 gesture dictionary based Support Vector Machine (SVM) classifier \cite{akl11}  Wrist-worn ACC based postural activity recognition approach has been proposed using Decision Tree, Random Forest, Support Vector Machines, K-Nearest Neighbors, Naive Bayes and deep neural networks \cite{gj14, wang16}, the accuracy stagnates at 85\% using SVM method \cite{martin16}  However, neither of past works proposed any technique that can provide single body worn ACC sensor-based multiple body contexts recognition nor works efficiently for diverse posture say walking normally, with walker, with double walker or wheel chair  Our proposed 8-hand gesture recognition technique assisted sparse-deconvolution method improves classification performances on both normal and diverse postures  However, we incorporated hand gestures and postures in conjunction with ambient sensors into single-inhabitant HDBN model \cite{alam16b} that provides significant improvement in complex activity recognition 
\subsection{Cognitive Health Assessment}
Smart home environment has been used for providing automated health monitoring and assessment in the ageing population before \cite{dawadi14, gong15, akl15, dawadi15}  `SmartFABER' proposed a non-intrusive sensor network based continuous smart home environmental sensor data acquisition and a novel hybrid statistical and knowledge-based technique to analyz the data to estimate behavioral anomalies for early detection of mild-cognitively impairment \cite{riboni16}  \cite{skubic15} presented an example of unobtrusive, continuous monitoring system for the purpose of assessing early health changes to alert caregivers about the potential signs of health hazards  Though, prior researches proposed a sequence of ambient motion sensor streams as complex activity components in activity based health assessment \cite{dawadi14, gong15, akl15, dawadi15}, we consider inclusion of an wearable wrist-band with in-built ACC sensor to detect hand gesture and posture, augmenting with the ambient sensor readings to help recognize complex activities as well as cognitive health assessment of older adults  Additionally, we propose intelligent use of physiological features of skin through different physiological sensor signals (EDA, PPG) processing in daily activity tasks and incorporate context-awareness for automation of cognitive health assessment that have not been explored before 
\begin{figure}[!htb]
\begin{center}
   \epsfig{file=flowchart pdf,height=1 6in, width=3 5in}
\caption{Overall flow of \emph{AutoCogniSys} pipeline }
   \label{fig:overview}
\end{center}
\end{figure}
\section{Overall Architecture}
We first investigate existing IoT-based cognitive health care frameworks that covers every aspects of wearable (physical, physiological) and ambient (passive infrared and object) sensor signals computing  \emph{AutoCogniSys} is comprised of three component modules: (i)~sensing, (ii)~processing, and (iii)~analysis  The `sensing' module consists of clinical assessment tools (surveys, observation and clinical backgrounds) and sensing signals (ambient and wearable sensors)  `Sensor processing' module is comprised of three sub-modules: a)~clinical assessment feature extraction from assessment tools; b)~ambient sensor feature extraction; and c)~wearable sensor processing (noise removal, segmentation, feature extraction, classification etc )  `Analysis' module is comprised of machine learning and statistical analytics-based score prediction of cognitive impairment  Automation of each module's functionality and inter-intra modular transactions without human interference can be called {\it true automation} of cognitive health assessment  Fig ~\ref{fig:overview} shows the overall flow of \emph{AutoCogniSys} which is discussed in details in the following sections 
\subsection{Demographic Ground Truth Data Collection}
Currently in standard clinical practice and research, the most accurate evaluations of cognitive health assessment are one-to-one observation and supervision tasks/questionnaires for monitoring an individual's functional abilities and behavior \cite{resnick15}  In the first stage of this pilot study, we have investigated current literatures and carefully chosen the clinically proven functional and behavioral health assessment survey tools \cite{resnick15}  On the other hand, to cross check with the survey based evaluations, we have also chosen clinically justified observation based behavioral assessment methods  First, following the resident consent, our clinical research evaluator collects demographic and descriptive data (age, gender, race, ethnicity, marital status, education and medical commodities)  She has performed two types of clinical assessments: (1) \emph{Observation based} where the resident's cognition is assessed using the Saint Louis University Mental Status (SLUMS) scale \cite{wai03}  (2) \emph{Survey based} where five widely used and clinically well validated surveys are taken into account: (a) \emph{Yale Physical Activity Survey} \cite{starling99}; (b) \emph{Lawton Instrumental Activities of Daily Living}; (c) \emph{Barthel Index of Activities of Daily Living} \cite{krapp07}; (d) \emph{Geriatric Depression Rating scale} \cite{yesavage82}; and (e) \emph{Zung Self-Rating Anxiety scale} \cite{zung71} 
\subsection{Smart Environment Creation}
For an ideal IoT-based system, instrumenting and deploying it at each participant's natural living environment warrants for assembling a flexible set of hardware and software interfaces to ease the system configuration, setup, and network discovery processes  The sensor system placed in the residences of volunteers needs to meet several specific physiological signals and activity monitoring needs  However, we must confirm that the devices are reliable with potential for re-deployment as well as appear unintimidating to the participants  Inspired by the above requirements, we developed a real testbed IoT system, {\it SenseBox}, by customizing Cloud Engine PogoPlug Mobile base station firmware to integrate with WiFi (connect ambient and object sensors) and Bluetooth (connect wristband) protocol  The smart home components are as follows: (i) PogoPlug base server with a continuous power supply, (ii) 3 binary Passive Infrared sensors in three different rooms (kitchen, livingroom and bedroom) to capture room level occupancy, (iii) 7 binary object sensors attached with closet door, entry door, telephone, broom, laundry basket, trash can and trash box, (iv) three IP cameras in the appropriate positions to collect the ground truth data and (v) an Empatica E4 \cite{empatica} wrist-band (integrated sensors: PPG at 64 Hz, EDA at 4 Hz, Body temperature at 1 Hz and a triaxial ACC at 32 Hz) on the participant's dominating hand 
\section{Activity Recognition}
We aim to detect single wrist-worn ACC sensor based hand gesture and postural activities and insert these into an HDBN graphical model in conjunction with ambient and object sensor values for complex activity recognition  We consider the recognition problem asan activity tupple of $\langle gesture,posture,ambient,object \rangle$  Though, Alam et  al  provides significant performance improvement for single wrist-worn ACC sensor aided 18-hand gesture based postural activity recognition in lab environment \cite{alam17}, it faces some practical challenges in real-time smart environment with older adults due to the diversity of their postures  For example, some older adults use walker, double walking sticks or wheel chair for walking in which cases collecting 18 hand gestures and corresponding postural activities for training requires endless efforts and carefulness  To reduce the complexity of ground truth labeling and later state space explosion for graphical model (HDBN), we propose to use rotational normalization method that can merge some hand-gestures subject to directional differences and forms an 8-hand gesture model  However, our proposed Feature Weight Naive Bayes (FWNB) classifier adds significant improvement on Alam et  al  proposed sparse-deconvolution method as well as recognition in diverse postural environment 
\begin{figure}[!htb]
\begin{center}
   \epsfig{file=hand_gestures pdf,height=0 5in, width=3in}
   \vspace{- 2in}
\caption{8 hand gesture dictionary with direction}
   \label{fig:hand_gestures}
   \vspace{- 2in}
\end{center}
\end{figure}
\subsection{Hand Gesture Recognition}
\label{sec:hand_gesture}
\emph{AutoCogniSys} proposes an 8-gesture dictionary (as shown in Fig  \ref{fig:hand_gestures}) and a Feature Weighted Naive Bayesian (FWNB) framework for building, modeling and recognizing hand gestures  The method comprises of the following steps: (i) \emph{Preprocessing:} wrist-worn ACC sensor provided 3-axis data are passed through 0 4Hz low-pass filter to remove the data drift  (ii) \emph{Rotation normalization:} Normalizing the rotation of hand gestures provides greater accuracy and allows for more realistic, orientation-independent motion  At first, we find the best fit plane of the acceleration vectors thus if the motion lies in a single plane, then the acceleration vectors of a closed shape should on average lie in that main plane  Then, we take all acceleration segments between points of inflection to form one single vector called reference vector that provides us the general direction of user's motion  After that, each vector is normalized relative to the reference vector  This normalization helps remove a lot of hand gestures from prior considered 18 hand gestures resulting a reduced dictionary of 8 gestures  (iii) \emph{Feature Weighted Naive Bayesian model:} Naive Bayes classifier is light-weight and efficient technique for hand gesture recognition  We extract 12 ACC features \cite{alam17} and calculate weight for each feature type based on the similarity of feature measures of the trained gestures (0$<$weight$<$1)  While recognizing gestures, the proximity of each feature measure to the average trained feature measure of each gesture type is calculated by a normal distribution  Then, the proximity value is multiplied by the feature weight that was calculated in the training phase   All of these multiplied values are added together and the system predicts the gesture type with the greatest value as the user gesture  In the learning data points, there should be static postural activities (such as sitting, lying etc ) to avoid unexpected noises over wrist-worn ACC sensors  In the final hand gesture dictionary, we save the reference vector as our signal dictionary 
\subsection{Postural Activity Recognition}
In normal lab environment, wrist-worn ACC sensor signal is a mixture (convolution) of actual hand gesture and postural activity relevant signals \cite{alam17}  \emph{AutoCogniSys} improves the idea by reducing the number of hand gestures and postural activities to 8 (as shown in Fig \ref{fig:hand_gestures}) using rotation normalization and 4 (walking, sitting, standing and lying)  Then, we use sparse-deconvolution method (with 31\% signal reconstruction error) to get Approximately Sparse Factor  The summary of the entire process is stated bellow:

{\it Building Deconvolution Method:} We first consider the wrist-worn ACC sensor signals (3-axis values) as a convolution of hand gesture and postural activity effects and build a deconvolution framework  The deconvolution framework takes a known signal (hand gesture effects) and a equalizer parameter ($\lambda$) as input and provides an Approximately Sparse Factor signal (postural activity effects) as output  For 3-axis ACC signals, we need to learn associated 3 equalizer parameters for each hand gesture  Moreover, each equalizer parameter is involved with 4 postural activities that results a total 96 ($8\times 3\times 4$) equalizer parameters to learn  

{\it Learning Classification Model:} We use the Approximately Sparse Factor signal to extract 12 statistical features and SVM with sequential machine optimization (SMO) \cite{cao06} for postural activity recognition 

{\it Prediction Model:} After recognizing the hand gestures following the method explained in Sec ~\ref{sec:hand_gesture}, we take the corresponding reference vector as known signal and extract the Approximately Sparse Factor signals incorporating corresponding 3 equalizer parameters ($\lambda$) for the sparse-deconvolution method  Then, we apply feature extraction and prior learned SMO based SVM classifier \cite{cao06} to classify final postural activity  Fig ~\ref{fig:deconvolution} illustrates a single axis example of the deconvolution 

\begin{figure}[!htb]
\begin{center}

   \epsfig{file=deconvolution pdf,height=1 6in, width=3in}
   \vspace{- 15in}
\caption{Sample deconvolution example of X-axis  The raw x-axis of accelerometer signal, reference vector of the sample gesture and the extracted corresponding ASF signal of walking }
   \label{fig:deconvolution}
\end{center}
\vspace{- 15in}
\end{figure}

\subsection{Complex Activity Recognition}
We build a HDBN based complex activity recognition framework for single inhabitant scenario smart home environment \cite{alam16b} taking the advantage of detected hand gestural and postural activities along with the ambient and object sensor streams  At first, we obtain instant hand gestural and postural activities from our above proposed models, and additionally motion sensor and object sensor readings from our IoT-system for every time instant generating a 4-hierarchy of HDBN model  Considering the context set $\langle gestural, postural, ambient,object\rangle$ as a hierarchical activity structure (extending two 2-hierarchical HDBN \cite{alam16b}), we build complex activity recognition model for single inhabitant scenario  Finally, we infer the most-likely sequence of complex activities (and their time boundaries), utilizing the well-known Expectation Maximization (EM) algorithm \cite{dempster77} for training and the Viterbi algorithm \cite{forney73} for run-time inference 
\section{Automatic Activity Features Estimation}
The effects of cognitive ability on daily activity performance have been studied before \cite{dawadi14,akl15}  They experimentally and clinically validated that cognitive impairment highly reduces the daily activity performances and this activity performance can be computed as an indicator of cognitive ability status of older adults  The standard activity features refer to completeness of task (TC), sequential task ability (SEQ), interruption avoidance capabilities (INT) etc  In current behavioral science literature, the above activity features carry specific definition based on the sub-tasks involved with a complex activity \cite{dawadi14,akl15}  Completeness of task refers to how many sub-tasks are missed by the participants  Sequential task ability refers to how many sequences of sub-tasks are missed referring the gerontologist defined standard sequences of the sub-task for the particular complex activity  Interruption avoidance capability refers to how many times the participants stop or interleave while doing any sub-task  The final goal of activity features estimation is to provide overall task score  The task score is proportional to the functional ability of participants in performance daily activities  Our behavioral scientist team, comprises with Nursing professor, gerontologist and retirement community caregivers, carefully discus, optimize and choose 87 sub-tasks in total for 13 complex activities 

Each of the sub-task comprises with sequential occurrences of hand gesture and postural activities  However, no researchers ever considered hand gesture for activity features estimation due to complexity of multi-modal wearable and ambient sensors synchronization and multi-label activity classification \cite{dawadi14,akl15}  \emph{AutoCogniSys} exploited single wrist-worn sensor based hand gesture and postural activity recognition, and proposed an activity features (TC, SEQ and INT) estimation method including these two parameters in conjunction with object and ambient sensor features that provide significant improvement of cognitive health assessment of older adults 
\subsection{Machine Learning Based Complex Activity Features Estimation}
In current cognitive health assessment literature, complex activity features can be defined as $\langle TC,SEQ,INT,TS\rangle$  We used supervised method to estimate TC, SEQ and INT, and unsupervised method to estimate TS  We first, formulate the automated scoring as a supervised  machine learning problem in which machine learning algorithms learn a function that maps $\langle${\it hand gesture, posture, object, ambient sensor}$\rangle$ feature set to the direct observation scores  We use bagging ensemble method to learn the mapping function and SMO based SVM \cite{cao06} as base classifier  The learner averages by boostrapping individual numeric predictions to combine the base classifier predictions and generates an output for each data point that corresponds to the highest-probability label  We train three classifiers considering observation as ground truth for TC, SEQ and INT scores and test on the testing dataset  We derive unsupervised scores using dimensionality reduction technique for each feature set  First, we take all features of each activity, apply optimal discriminant analysis technique as a dimensionality reduction process \cite{zhang09} and reduce the feature sets into single dimensional value which represents the automated task completeness scores of the particular user activity  A min-max normalization is applied that provides us a uniform range of the variables using $
z_i=\frac{x_i-min(x)}{max(x)-min(x)}$ equation where $x=\{x1,\ldots,x_n\}$ and $z_i$ is $i^{th}$ normalized data  The final single dimensional score represents machine learning based TS score 
\section{Physiological Sensor Signals Processing}
The autonomic nervous system (ANS) restrains the body's physiological activities including the heart rate, skin gland secretion, blood pressure, and respiration  The ANS is divided into sympathetic (SNS) and parasympathetic (PNS) branches  While SNS actuates the body's resources for action under arousal conditions, PNS attenuates the body to help regain the steady state  Mental arousal (say stress, anxiety etc ) activates the sweat gland causing the increment and reduction of  Skin Conductance on SNS and PNS physiological conditions respectively  However, Instant Heart Rate also has similar effect on SNS and PNS physiological condtions i e , a higher value of heart rate is the effect of SNS and lower value is the outcome of PNS  EDA and PPG sensors are widely used to estimate the instant value of skin conductance and heart rate respectively \cite{alam16} 
\subsection{EDA Sensor Signal Processing}
EDA is the property of the human body that causes continuous variation in the electrical characteristics of the skin which varies with the state of sweat glands in the skin  There are three types of arousal: \emph{cognitive, affective and physical}  \emph{Cognitive} arousal occurs when a person tries to solve any problem using her cognitive ability  \emph{Affective} arousal occurs when a person is worried, frightened or angry either doing daily activities or in resting position  On the other hand, \emph{physical} arousal is related to the brain command to move bodily parts which is imposed on the total arousal as an artifact, called \emph{motion artifact}  However, there are always some noises due to the weather conditions (temperature, humidity etc ) and device motion  This \emph{motion artifact} can be the prime cause of signal contamination of physiological outcomes while performing daily activities which must be removed  \emph{AutoCogniSys} proposes an EDA sensor signal processing method consists of three steps: (i) noise and motion artifacts removal, (ii) separation of tonic component and phasic component (explained later) from contamination free EDA signal and (iii) feature extraction on the response window 
\subsubsection{Motion Artifacts Removal}
There are many types of motion artifacts but the unsual steep rise is the mostly occured ones associated with EDA signal while performing daily activities \cite{edel67}  We use well-known steep rising noises reduction technique, SWT \cite{chen15}  We first consider EDA signal as a mixture of a slow variant tonic and fast variant phasic component, i e , SWT coefficient is modeled as a mixture of two Gaussian components, phasic (close to zero valued signal) and tonic (high rising signal)  After expanding EDA signal into multiple levels of scaling and wavelet coefficients, we choose adaptively a threshold limit at each level based on the statistical estimation of the wavelet coefficients' distribution, and employ that on the wavelet coefficients of all levels  Finally, an inverse wavelet transform technique is applied to the thresholded wavelet coefficients to obtain the artifacts free EDA signal  Fig~ \ref{fig:eda_artifact_removal} shows a sample of raw and motion artifacts free EDA signal 

\begin{figure}[!htb]
\begin{center}
\vspace{- 1in}
   \epsfig{file=eda_signal_artifact pdf,height=1 6in, width=3 5in}
\caption{Dashed line represents noisy EDA signal and solid red line represents \emph{AutoCogniSys} proposed motion artifact free EDA signal}
   \label{fig:eda_artifact_removal}
\end{center}
\end{figure}
\subsubsection{Convex Optimization Technique to EDA Deconvolution}
After the motion artifact removal, we consider EDA as the sum of three components for $N$ sample: a slow tonic driver ($t$), fast (compact, bursty) non-negative sparse phasic driver ($r$) and a reminder error term ($\epsilon_r$) 
\begin{equation}
\label{eq:eda_signal}
y = t + r + \epsilon_r
\end{equation}
This additive error $\epsilon_r$ is a White Gaussian Noise  The central problem associated with the deconvolution method is to get tonic $t$ component from the above equation  \cite{greco16} showed that EDA signal deconvolution (separation of tonic, phasic and noise terms from EDA signal) is a quadratic optimization problem and defined tonic component as follows:
\begin{equation}
\label{eq:tonic}
t = Bl + Cd,
\end{equation}
where $B$ is a tall matrix whose columns are cubic $B$-spline basis functions, $l$ is the vector of spline coefficients, $C$ is a $N\times 2$ matrix, $d$ is a $2\times 1$ vector with the offset and slope coefficients for the linear trend  The above equation is subject to the following optimization problem,
\begin{eqnarray}
minimize \frac{1}{2} {||Mq + Bl + Cd- y||}^2_2 +\alpha {||Aq||}_1 + \frac{\lambda}{2} {||l||}^2_2\\
subject\;to\; Aq \geq 0\nonumber
\end{eqnarray}
where $M$ and $A$ are tridiagonal matrices and $q$ is an auxiliary variable
Context 3: McPherson County (standard abbreviation: MP) is a county located in the U S  state of Kansas   As of the 2020 census, the county population was 30,223  The largest city and county seat is McPherson  The county is named for Civil War General James B  McPherson 

History

Early history

For many millennia, the Great Plains of North America was inhabited by nomadic Native Americans  From the 16th century to 18th century, the Kingdom of France claimed ownership of large parts of North America  In 1762, after the French and Indian War, France secretly ceded New France to Spain, per the Treaty of Fontainebleau  In 1802, Spain returned most of the land to France, but keeping title to about 7,500 square miles 

In 1803, most of the land for modern day Kansas was acquired by the United States from France as part of the 828,000 square mile Louisiana Purchase for 2 83 cents per acre  In 1848, after the Mexican–American War, the Treaty of Guadalupe Hidalgo with Spain brought into the United States all or part of land for ten future states, including southwest Kansas  In 1854, the Kansas Territory was organized, then in 1861 Kansas became the 34th U S  state 

19th century

From the 1820s to 1870s, the Santa Fe Trail passed through, what is now McPherson County  The trail entered the county, east of Canton, then south of Galva, then north of Inman, and west towards Lyons  In 1855, Charles O  Fuller established a ranch adjacent to the Running Turkey Creek Crossing about two miles south and one mile east of Galva  Fuller's Ranch provided accommodations for travelers on the Santa Fe Trail and was probably the first white settlement in McPherson County 

Peketon County was established in 1860, by the passage of a bill by S  N  Wood:  An act to establish Peketon County  Section 1  - That all that territory west of the sixth principal meridian and south of Township 16, in Kansas Territory, be and the same is hereby erected into a county, to be known by the name of Peketon County  On February 17, 1865, Peketon County was abolished, and McPherson County was made a part of Marion County, which extended from the west line of Chase County to the present western boundary of Kansas 

In 1868, Solomon Stephens and L  N  Holmberg were appointed Justices of the Peace—the first officers in what is now McPherson County  The next year (1869) occurred the first election for the township, now the county of McPherson  McPherson was regularly organized as a county in the spring of 1870, a mass meeting being held at Sweadal  Sweadal, the county seat thus selected, was located about one mile and a half southwest of the present site of Lindsborg  In September, however, the County Commissioners resolved to meet at the latter place, McPherson which had already been located some two years 

In April, 1873, a petition was filed for the county seat re-location  It was signed by 483 voters, and a special election was accordingly ordered for June 10  Upon that day, McPherson received 605 votes, New Gottland 325, King City 3 and Lindsborg 1; McPherson's majority over all, 276  In May the McPherson Town Company had offered, as an inducement for the location of the county seat at this point, the free use of rooms for ten years, and the donation of two squares of land on the town site  The offer was accepted the next month, the County Commissioners selecting blocks 56 and 65  Thus the county seat was established at McPherson and has remained since 

As early as 1875, city leaders of Marion held a meeting to consider a branch railroad from Florence  In 1878, Atchison, Topeka and Santa Fe Railway and parties from Marion County and McPherson County chartered the Marion and McPherson Railway Company   In 1879, a branch line was built from Florence to McPherson, in 1880 it was extended to Lyons, in 1881 it was extended to Ellinwood  The line was leased and operated by the Atchison, Topeka and Santa Fe Railway  The line from Florence to Marion, was abandoned in 1968  In 1992, the line from Marion to McPherson was sold to Central Kansas Railway  In 1993, after heavy flood damage, the line from Marion to McPherson was abandoned  The original branch line connected Florence, Marion, Canada, Hillsboro, Lehigh, Canton, Galva, McPherson, Conway, Windom, Little River, Mitchell, Lyons, Chase, then connected with the original AT&SF main line at Ellinwood 

In 1887, the Chicago, Kansas and Nebraska Railway extended its main line from Herington to Pratt   This main line connected Herington, Ramona, Tampa, Durham, Waldeck, Canton, Galva, McPherson, Groveland, Inman, Medora, Hutchinson, Whiteside, Partridge, Arlington,  Langdon, Turon, Preston, Natrona, Pratt   In 1888, this main line was extended to Liberal   Later, this line was extended to Tucumcari, New Mexico and Santa Rosa, New Mexico, where it made a connection with the Southern Pacific from El Paso, Texas   The Chicago, Kansas and Nebraska Railway was absorbed by the Chicago, Rock Island and Pacific Railway  This line is also called the "Golden State Route" 

20th century
The National Old Trails Road, also known as the Ocean-to-Ocean Highway, was established in 1912, and was routed through Windom, Conway, McPherson 

Geography

According to the U S  Census Bureau, the county has a total area of , of which  is land and  (0 3%) is water 

Adjacent counties
 Saline County (north)
 Dickinson County (northeast)
 Marion County (east)
 Harvey County (southeast)
 Reno County (southwest)
 Rice County (west)
 Ellsworth County (northwest)

Major highways
  Interstate 135
  U S  Route 56
  U S  Route 81
  K-4
  K-61
  K-153

Demographics

The McPherson Micropolitan Statistical Area includes all of McPherson County 

2000 census
As of the census of 2000, there were 29,554 people, 11,205 households, and 7,966 families residing in the county   The population density was 33 people per square mile (13/km2)   There were 11,830 housing units at an average density of 13 per square mile (5/km2)   The racial makeup of the county was 96 53% White, 0 81% Black or African American, 0 34% Native American, 0



ground_truth: Electricity is used for transport, heating, lighting, communications, and computation.

prompt_front: Now, answer the following question based on the text below, only give me the answer and do not output any other words.

Question: What types of sensors are now capable of estimating physical activity levels and physiological outcomes of older adults?

Read the following text and answer briefly.

Context 2:  After solving the above equation, we can get the optimal values for $\{q,l,d\}$ that can be used to obtain tonic component from the equation~\ref{eq:tonic}  The reminder of the equation~\ref{eq:eda_signal} ($r+\epsilon_r$) is considered as a mixture of White Gaussian Noise ($\epsilon_r$) and a fast variant phasic component ($r$)  We employ butterworth low-pass filter (5Hz) and hanning smoothing with window size 4 (optimal) to remove $\epsilon_r$ from phasic component ($r$) 
\subsection{PPG Signal Processing}
PPG is used mainly for measuring the oxygen saturation in the blood and blood volume changes in skin  An ideal PPG signal processing must contain the following steps: noise and motion artifacts removal, heart rate detection, heart rate variability estimation and feature extraction 
\subsubsection{PPG Signal Noise and Motion Artifacts Removal}
Similar to EDA signal, PPG signal is also contaminated with motion artifacts and noises  However, unlike EDA signal, PPG produce quasiperiodicity in a time series spectrum \cite{mete30}  We use Periodic Moving Average Filter (PMAF) to remove motion artifacts and noises \cite{lee07}  We first segment the PPG signal on periodic boundaries and then average the $m^{th}$ samples of each period  After filtering the input PPG signal with a 5-Hz $8^{th}$-order Butterworth low-pass filter, we estimate the maximum and minimum value of each period  The mean of each period are obtained from the maximum and minimum values applying the zero crossing method  These points of the means help determine the boundaries of each period  Then, interpolation or decimation is performed to ensure that each period had the same number of samples \cite{lee07}  
\subsubsection{Heart Rate and Heart Rate Variability Estimation}
We first apply PMAF on PPG signal to remove noises and motion artifacts, refine PPG by smoothing the signal using 1-dimensional Gaussian Filter and Convolution, calculate first derivative of the convoluted signal and finally find the differences between two consecutive peak values which is called HRV \cite{sel08}  The occurrences of total peak values (R-peak or beat) in each minute is called Heart Rate (HR) with an unit of Beat Per Minute  The signal value property of HRV and HR are inversely proportional which means the mental arousal that increases HR should decrease HRV in the time segment window  Fig~\ref{fig:ppg_artifact_removal} shows a sample of the noisy and filtered PPG signal and their corresponding Instant Heart Rate 
\begin{figure}[!htb]
\vspace{- 1in}
\begin{center}
   \epsfig{file=ppg_artifact_removal pdf,height=1 4in, width=3 5in}
   \vspace{- 15in}
\caption{Top figure illustrates the noisy signal (dotted line) and filtered signal from PPG sensor based on our filtering method  Bottom figure illustrates instant heart rate calculated from noisy signal (dotted line) and filtered signal}
   \label{fig:ppg_artifact_removal}
\end{center}
\vspace{- 15in}
\end{figure}
\subsection{Physiological Sensor Signal Feature Extraction}
Using the above mentioned methods, we removed the noises and motion artifacts from EDA and PPG signals and generated two time series signal from EDA (tonic and phasic components) and one time series signal from PPG (HRV)  Then, we segment each of the time series signal based on our prior detected complex activities such that each response window starts and ends with the starting and ending points of each complex activity  We extract 7 statistical time-series features for EDA (as shown in Table~\ref{tab:eda_features}) and 8 features for HRV (Table~\ref{tab:hrv_features}) within the response window) 

\begin{table}[!t]
\begin{center}

\renewcommand{\arraystretch}{1}
\caption{EDA Features Within The Response Window}
\begin{scriptsize}


\label{tab:eda_features}
\begin{tabular}{|c|l|}
\hline
\bfseries Features& \bfseries Description\\
\hline
nSCR & Number of SCRs within response window (wrw)\\
\hline
Latency & Response latency of first significant SCR wrw\\
\hline
AmpSum & Sum of SCR-amplitudes of significant SCRs wrw\\
\hline
SCR & Average phasic driver wrw\\
\hline
ISCR & Area (i e  time integral) of phasic driver wrw\\
\hline
PhasicMax & Maximum value of phasic activity wrw\\
\hline
Tonic & Mean tonic activity wrw\\
\hline
\end{tabular}
\end{scriptsize}
\end{center}
\end{table}



\begin{table}[!t]
  \begin{center}
\renewcommand{\arraystretch}{1}
\vspace{- 3in}
\caption{Heart Rate Variability features}
\label{tab:hrv_features}
\begin{scriptsize}
\begin{tabular}{|c|l|}

\hline
\bfseries Feature& \bfseries Description\\
\hline
$\overline{RR}$&Mean RR intervals\\
\hline
SDNN&Standard deviation of RR intervals\\
\hline
SDSD&Std of successive RR interval differences\\
\hline
RMSSD&Root mean square of successive differences\\
\hline
NN50&\#successive intervals differing more than 50 ms\\
\hline
pNN50&relative amount of NN50\\
\hline
HRVTI&Total number of RR intervals/height of the histogram\\
\hline
TINN&Width of RR histogram through triangular interpolation\\
\hline
\end{tabular}
\end{scriptsize}
  \end{center}
\end{table}
\section{Experimental Evaluation}
In this section, we explain our data collection, available benchmark dataset, baseline methods and evaluation 
\subsection{Datasets and Baseline Methods}
We validate and compare \emph{AutoCogniSys} with baseline methods on both publicly available and our collected datasets 
\subsubsection{RCC Dataset: Collection and Ground Truth Annotation}
For collecting Retirement Community Center Dataset (RCC Dataset), we recruited 22 participants (19 females and 3 males) with age range from 77-93 (mean 85 5, std 3 92) in a continuing care retirement community with the appropriate institutional IRB approval and signed consent  The gender diversity in the recruited participants reflects the gender distribution (85\% female and 15\% male) in the retirement community facility  A trained gerontology graduate student evaluator completes surveys with participants to fill out the surveys  Participants are given a wrist band to wear on their dominant hand, and concurrently another trained IT graduate student have the IoT system setup in participants' own living environment (setup time 15-30 minutes)  The participants are instructed to perform 13 \emph{complex ADLs}  Another project member remotely monitors the sensor readings, videos and system failure status  The entire session lasts from 2-4 hours of time depending on participants' physical and cognitive ability 

We follow the standard protocol to annotate demographics and activities mentioned in the IRB  Two graduate students are engaged to annotate activities (postural, gestural and complex activity) whereas the observed activity performances are computed by the evaluator  Two more graduate students are engaged to validate the annotations on the videos  In overall, we are able to annotate 13 complex activities (total 291 samples) labeling for each participant; 8 hand gestures (total 43561 samples) and 4 postural activities (total 43561 samples) labeling  Annotation of postural and complex activities outcomes no difficulties from recorded videos  However, annotation of hand-gestures is extremely difficult in our scenario  We used video based hand tracker that can track and sketch wrist movements from a video episode \cite{hugo14}  This sketching can help us significantly to identify which particular hand gesture is being performed in the time segment 
\subsubsection{EES Datasets: EDA and PPG Sensor Datasets}
We used Eight-Emotion Sentics (EES) dataset to validate \emph{AutoCogniSys} proposed physiological signal processing approaches \cite{picard01}  The dataset consists of measurements of four physiological signals (PPG/Blood Volume Pulse, electromyogram, respiration and Skin Conductance/EDA) and eight affective states (neutral, anger, hate, grief, love, romantic love, joy, and reverence)  The study was taken once a day in a session lasting around 25 minutes for 20 days of recordings from an individual participant  We consider only PPG and EDA for all of the affective states in our study 
\subsubsection{Baseline Methods}
Though no frameworks ever combined all modalities together into real-time automated cognitive health assessment, we evaluate \emph{AutoCogniSys} performance by comparing the performances of its components individually with upto date relevant works  For hand gesture and postural activity recognition, we consider \cite{alam17} proposed method as baseline  For complex activity recognition, we compare our hand gesture and postural activity classifiers aided HDBN model with three-level Dynamic Bayesian Network \cite{zhu12} framework  For activity performance estimation, activity performance based cognitive health assessment; and EDA and PPG based cognitive health assessment, we have considered \cite{alam16} proposed method as baseline 
\subsection{Activity Recognition Evaluation}
The standard definition for \emph{accuracy} in any classification problem is $\frac{TP+TN}{TP+TN+FP+FN}$ where $TP,TN,FP$ and $FN$ are defined as true positive, true negative, false positive and false negative  For complex activity recognition evaluation, we additionally consider \emph{start/end duration error} as performance metric that can be explained as follows: consider that the true duration of ``cooking'' is 30 minutes (10:05 AM - 10:35 AM) and our algorithm predicts 29 minutes (10 10 - to 10 39 AM)  Then, the start/end duration error is 9 minutes ($|$5 minutes delayed start$|$ + $|$4 minutes hastened end$|$), in an overall error of e g , 30\% (9/30=0 3)  We measure cross-participant accuracy using leave-two-participants-out method for performance metrics, i e , we take out two of the participants' data points from the entire dataset, train our proposed classification models, test the model accuracy on the two left-out participants relevant data points, and continue the process for entire dataset 

\begin{figure*}[!htb]
\begin{minipage}{0 45\textwidth}
\begin{center}
   \epsfig{file=hand_gesture_accuracy pdf,height=1 6in, width=3in}
\caption{Feature Weighted Naive Bayes (FWNB) classification accuracy comparisons with baseline approaches (graphical signatures of all hand gestures are shown) }
   \label{fig:hand_gesture_accuracy}
\end{center}
\end{minipage}
\begin{minipage}{0 29\textwidth}
\begin{center}
\vspace{- 12in}
   \epsfig{file=posture_accuracy_normal pdf,height=1 6in, width=2 1in}
\caption{4-class postural level activity recognition performance and comparisons with baseline method}
   \label{fig:posture_accuracy_normal}
\end{center}
\end{minipage}
\begin{minipage}{0 25\textwidth}
 \begin{center}
 \vspace{- 12in}
   \epsfig{file=posture_accuracy_extended pdf,height=1 6in, width=2 1in}
\caption{6-class diverse postural activity recognition framework accuracy comparisons with the baseline approach }
   \label{fig:posture_accuracy_extended}
\end{center}
 \end{minipage}
\end{figure*}

Fig~\ref{fig:hand_gesture_accuracy} displays Feature Weighted Naive Bayes (FWNB) based the 8-hand gestural activity recognition accuracies comparisons with the baseline methods which clearly depicts the outperformance of our method (5\% improvement) with an overall accuracy of 92\% (FP rate 6 7\%) in RCC dataset  For postural activity recognition, dataset achieving 91\% postural activity recognition accuracy (FP rate 9 5\%) which outperforms the baseline approach significantly (8\% improvement)  Now, we expand the postural activities for RCC datasets into 3 diverse `walking' postures: `normal walking', `walking with walker', `walking with single stick' and the accuracy goes down to 88\% (FP 7 9\%)  Fig ~\ref{fig:posture_accuracy_normal} and Fig ~\ref{fig:posture_accuracy_extended} illustrate 4-class postural and extended 6-class postural classifier accuracies respectively which clearly posit that \emph{AutoCogniSys} outperforms in each case of postural activities as well as overall performances (8\% and 7\% improvement respectively) 

For complex activity classification, we choose RCC dataset to train our HDBN model  Our leave-two-participants out method results an accuracy of 85\% (FP Rate 3 6\%, precision 84 2\%, recall 84 5\%, ROC Area 98 2\%) with a start/end duration error of 9 7\%  We run the entire evaluation for baseline complex activity recognition algorithm too achieving an overall accuracy of 78\% (FP Rate 5 2\%, precision 79 6\%, recall 78 5\%, ROC Area 82 7\%) which is clearly lower performed method than our approach  Fig  \ref{fig:complex_activity_roc} and Fig~\ref{fig:complex_activity_accuracy} illustrate the ROC curve and each complex activity recognition accuracy comparisons with baseline method which depict the outperformance of our framework over baseline methods (7\% improvement)  Fig~\ref{fig:complex_activity_accuracy} also shows that inclusion of postural activity improves the final complex activity recognition (4\% improvement) 
 \begin{figure}  [!htb]
  \begin{minipage}{0 15\textwidth}
 \begin{center}
   \epsfig{file=complex_activity_roc pdf,height=1 4in, width=1 1in}
\caption{ROC curve for complex activity recognition}
   \label{fig:complex_activity_roc}
\end{center}
\end{minipage}
\begin{minipage}{0 33\textwidth}
\begin{center}

   \epsfig{file=complex_activity_accuracy pdf,height=1 4in, width=2 3in}
\caption{Complex ADLs recognition accuracy improvement and comparison with baseline \cite{zhu12} and HMM based method}
   \label{fig:complex_activity_accuracy}
\end{center}

\end{minipage}
\end{figure}

\subsection{Quantification of Performance Score}
To characterize both the qualitative and quantitative health assessment performance scores, we start with four different feature groups ranging from both functional and physiological health measures: (i) observation based activity features, (ii) automatic activity performance features, (iii) EDA features and (iv) PPG features 

In \emph{observation based activity features}, we design a complex activity set comprised of multiple subtasks which are involved with task {\it interruption, completion and sequencing}  Participants are instructed to perform the complex activities while the trained evaluator observed the aforementioned functional activity performance measures  Each incorrect attempt of performance measure will be assigned one point thus higher score reflects lower performance of functional activities \cite{dawadi14}  We first detect hand gesture and postural activities  Then, we feed the low-level activity contexts (gestural and postural) combined with ambient contexts (object and ambient motion sensor readings) into HDBN for single inhabitant model \cite{alam16b} to recognize complex activities  The complex activity recognition framework provides both activity labels and activity window (start-end points)  Then, we extract features of object sensor, ambient sensor, gestural activity and postural activity events for each activity window  The features are number of occurrences, mean number of occurrences, consecutive 1, 2, 3, $\ldots$ 20 occurrences, top 10, 20, 30, $\ldots$, 90 percentile etc (29 features in total)  In \emph{physiological features} we first detect 13 complex activities using HDBN algorithm which provides activity labels and activity window (start-end points), apply noise reduction, motion artifacts removal, extract 7 EDA features and 8 HRV features for each activity and take the mean of them over time (minutes) to get 15 (7+8) complex activity physiological features set for each participant  In summary, we extract 3 observation based activity features, 29 automatic activity performance features, 7 EDA features and 8 HRV features 
\subsection{Physiological Signal Processing Performance Evaluation}
Standard evaluation technique should use both experimental and publicly available datasets to confirm the outperformance of the novel approaches  We first evaluate our physiological signal processing techniques using a publicly available dataset (EES Dataset \cite{picard01}) to detect 8 human emotions  Then, in next section, we evaluate our methods in assessing cognitive health status of older adults using RCC dataset 

For EDA, we first apply SWT method to remove motion artifacts and noises  Then, we use cvxEDA method to separate tonic and phasic components of EDA  Then, we extract 7 EDA features on a sliding window of 4 seconds  Finally, we feed the 7 EDA features into a SMO based SVM algorithm \cite{cao06}  We use 10-fold cross validation to classify eight emotions achieving 87\% of overall accuracy (FP rate 6\%)  For PPG, we first apply our proposed PMAF based noises and motion artifacts removal technique  Then, we calculate HRV and perform time-domain feature extraction to extract 8 HRV features on a sliding window of 4 seconds  We feed these features into a SMO based SVM algorithm \cite{cao06}  Our 10-fold cross validation shows accuracy of 79\% (FP rate 11 5\%) of detecting 8 emotions on EES Dataset  Fig  \ref{fig:ees_eda} and Fig  \ref{fig:ees_ppg} clearly depict that \emph{AutoCogniSys} proposed EDA and PPG signal processing techniques significantly improve the accuracy over the baseline \cite{alam16} method (10\% and 12\% improvement) 

\begin{figure}[!htb]
\begin{minipage}{0 24\textwidth}
\begin{center}
   \epsfig{file=ees_eda pdf,height=1 2in, width=1 8in}
\caption{(EES Databaset) EDA features based Eight Emotion classification accuracy comparisons with baseline method}
   \label{fig:ees_eda}
\end{center}
\end{minipage}
\begin{minipage}{0 23\textwidth}
\begin{center}
   \epsfig{file=ees_ppg pdf,height=1 2in, width=1 7in}
\caption{(EES Dataset) PPG features based 8-Emotion classification accuracy comparisons with baseline method}
   \label{fig:ees_ppg}
\end{center}
\end{minipage}

\end{figure}
\subsection{Evaluation of Performance Scores}
The feature subsets used in the experimentation for observation and survey based clinical assessments and technology guided physiological and activity initiated health assessments are depicted in Table~\ref{tab:feature_subset}  From our 6 demographics surveys, we find significant distributions in terms of cognition only for SLUMS Score (S-Score)  Based on that, we divide our participants pool into three groups: \emph{Not Cognitively Impaired (NCI), Mild Cognitively Impaired (MCI) and Cognitively Impaired (CI)} where the number of participants are $5$, $7$ and $10$ respectively 
\begin{table}[!t]
\begin{scriptsize}


{\centering 
\renewcommand{\arraystretch}{ 6}
\caption{Feature Subsets}
\label{tab:feature_subset}
\begin{tabular}{|l|L{5 5cm}|}
\hline
\bfseries Feature& \bfseries Description\\
\hline
Observation & Task Completeness (TC), Sequencing (SEQ), Interruptions (INT)\\
\hline
Survey & SLUMS Score (S-Score), ZUNG Score (Z-Score), IADL Score (I-Score), Yale Score (YPAS), Barthel Score (B-Score), GDS Score (G-Score)\\
\hline
EDA  and HRV & 7 and 8 Features\\
\hline
Activity Performance& Supervised (TC, SEQ, INT), Unsupervised\\
\hline
Arousal& EDA and HRV features of each complex activity window\\
\hline

\end{tabular}
}
\end{scriptsize}
\end{table}


\begin{figure}[!htb]
\begin{center}
   \epsfig{file=group_correlation pdf,height=1in, width=3 3in}
\caption{\emph{AutoCogniSys} Proposed Method Based Group Correlation analysis ( $r-value$) NCI, MCI and CI represent not cognitive, mild cognitive and cognitively impaired group of population  TC, INT, SEQ, EDA and HRV represent task completeness, interruption scores, sequencing scores, electrodermal activity features and heart rate variability features}
   \label{fig:group_correlation}
\end{center}
\vspace{- 2in}
\end{figure}
\begin{figure}[!htb]
\begin{center}
   \epsfig{file=group_correlation_baseline pdf,height=1in, width=3 3in}
\caption{Baseline \cite{alam16} method based Group Correlation analysis ( $r-value$)}
   \label{fig:group_correlation_baseline}
   \vspace{- 25in}
\end{center}
\end{figure}

\subsection{Statistical Correlation Analysis of Cognitive Health}
We used Pearson correlation coefficients with significance on $p<0 05$* for individual feature and partial correlation coefficients with significance on $p<0 005$** for group of features correlation analysis  Fig  \ref{fig:group_correlation} and Fig  \ref{fig:group_correlation_baseline} show the group correlation analysis results based on \emph{AutoCogniSys} proposed framework and baseline \cite{alam16} framework respectively  It can be clearly depicted that our proposed framework improves the correlation with the ground truths 
\subsection{Machine Learning Classification of Cognitive Health}
We evaluate using machine learning classifiers to predict cognitive status of older adults using both individual modalities and combined features  We use leave-two-participants out method to train and test classification accuracy 

We first choose the individual activity features (machine learning method based interruption scores, sequencing scores, unsupervised scores) and their combined features to train and test cognitive impairment status classification for SMO based SVM algorithm \cite{cao06}  The classification accuracies are 72\%, 69\%, 76\% and 83\% respectively  Then we consider 7 EDA-activity features and 8 HRV-activity features individually in training and testing phase of SMO based SVM algorithm \cite{cao06} resulting 85\% and 80\% accuracy respectively 

\begin{figure}[!htb]
\begin{minipage}{0 24\textwidth}
\begin{center}
   \epsfig{file=combined_classification pdf,height=1 2in, width=1 7in}
   \vspace{- 15in}
\caption{Individual and combined classification accuracies comparison with baseline method for cognitive impairment status detection}
   \label{fig:combined_classification}
\end{center}
\end{minipage}
\begin{minipage}{0 23\textwidth}
\begin{center}
   \epsfig{file=each_activity_cognitive_assessment pdf,height=1 2in, width=1 7in}

\caption{Machine learning based cognitive health assessment accuracy for each complex activity in terms of activity, EDA and HRV features }
   \label{fig:each_activity_cognitive_assessment}
\end{center}
\end{minipage}
\end{figure}

For combined classifier, we first applied sequential forward feature selection to find the best combinations of 1- 3 features for cognitive impairment classification group MCI, NCI and CI in terms of combined activity features (29 features), EDA-activity features (7 features) and HRV-activity features (8) features  Our final combined classifier (SMO based SVM algorithm \cite{cao06}) provides an accuracy of {\bf 93\%} in detecting the cognitive impairment status of older adults  Fig  \ref{fig:combined_classification} shows our proposed individual and combined methods outperform the baseline \cite{alam16} significantly (13\% improvement)  Fig  \ref{fig:each_activity_cognitive_assessment} shows the cognitive impairment status prediction accuracy for each modality (activity feature, EDA and HRV) per individual complex activity 
\subsection{Discussion}
If we exclude the postural activities from automated activity performance scoring, we find reduced statistical correlation with original task completeness performance for \{NCI, MCI, CI\} participant group (INT 0 53*, SEQ 0 21' and unsupervised 0 49')  However, if we skip our proposed motion artifact removal stage, we find reduced statistical correlation with \{NCI, MCI\} and \{MCI, CI\} groups of participants (EDA and HRV correlations respectively \{0 51*, -0 51*\} and \{-0 53*,0 46\})  To test our proposed motion artifacts removal impact on EDA signals more rigorously, we choose 5 random participants, engage one expert motion artifact annotator to annotate motion artifacts segment on each participant's first 30 minutes of complex dataset using recorded video and apply both baseline and our methods to detect motion artifact segments  While baseline method achieves 75 5\% (FP rate 20 3\%) accuracy in detecting motion artifact segments, \emph{AutoCogniSys} outperforms achieving 89 9\% (FP rate 8 9\%) accuracy  In terms of experience, we have seen 100\% acceptance of wearing wrist-band,  71\% of acceptance for signing consent on using cameras and 0\% failure rate of collecting continuous data 
\section{Conclusion}
We propose, \emph{AutoCogniSys}, an IoT inspired design approach combining wearable and ambient sensors embedded smart home design, extensive signal processing, machine learning algorithms and statistical analytics to automate cognitive health assessment in terms of complex activity performances and physiological responses of daily events  Additionally, our postural activity detection approach in diverse population cum improved activity performance measurement and fundamental physiological sensor artifacts removal from physiological sensors help facilitate the automated cross-sectional cognitive health assessment of the older adults  Our efficient evaluation on each modality (physical, physiological and ambient) and each activity mode proves that any of the mode (say single activity and single sensor) also can provide significant improved cognitive health assessment measure 




Context 3: 32% Asian, 0 06% Pacific Islander, 0 79% from other races, and 1 16% from two or more races   1 94% of the population were Hispanic or Latino of any race  37 1% were of German, 12 9% Swedish, 12 1% American, 6 7% English and 6 3% Irish ancestry according to Census 2000 

There were 11,205 households, out of which 33 00% had children under the age of 18 living with them, 62 50% were married couples living together, 6 00% had a female householder with no husband present, and 28 90% were non-families  25 50% of all households were made up of individuals, and 11 80% had someone living alone who was 65 years of age or older   The average household size was 2 49 and the average family size was 2 99 

In the county, the population was spread out, with 25 40% under the age of 18, 10 30% from 18 to 24, 25 20% from 25 to 44, 21 80% from 45 to 64, and 17 30% who were 65 years of age or older   The median age was 38 years  For every 100 females there were 95 90 males   For every 100 females age 18 and over, there were 92 90 males 

The median income for a household in the county was $41,138, and the median income for a family was $48,243  Males had a median income of $33,530 versus $21,175 for females  The per capita income for the county was $18,921   About 4 20% of families and 6 60% of the population were below the poverty line, including 5 20% of those under age 18 and 8 10% of those age 65 or over 

Government

Presidential elections
McPherson county is often carried by Republican candidates  The last time a Democratic candidate has carried this county was in 1964 by Lyndon B  Johnson 

Laws
Following amendment to the Kansas Constitution in 1986, the county remained a prohibition, or "dry", county until 1996, when voters approved the sale of alcoholic liquor by the individual drink with a 30 percent food sales requirement 

Education

Colleges
 McPherson College in McPherson
 Bethany College in Lindsborg
 Central Christian College in McPherson

Unified school districts
 Smoky Valley USD 400
 McPherson USD 418
 Canton-Galva USD 419
 Moundridge USD 423
 Inman USD 448

School district office in neighboring county
 Goessel USD 411
 Little River-Windom USD 444

Museums
 Birger Sandzén Memorial Gallery in Lindsborg
 McCormick-Deering Days Museum in Inman
 McPherson Museum in McPherson
 Lindsborg Old Mill & Swedish Heritage Museum in Lindsborg
 Kansas Motorcycle Museum in Marquette

Communities

Cities

 Canton
 Galva
 Inman
 Lindsborg
 Marquette
 McPherson (county seat) 
 Moundridge
 Windom

Unincorporated communities
† means a Census-Designated Place (CDP) by the United States Census Bureau 
 Conway
 Elyria†
 Groveland
 Johnstown
 New Gottland
 Roxbury†

Ghost towns
 Alta Mills
 Battle Hill
 Christian
 Doles Park
 Elivon
 King City
 Sweadal

Townships
McPherson County is divided into twenty-five townships   The cities of Lindsborg and McPherson are considered governmentally independent and are excluded from the census figures for the townships   In the following table, the population center is the largest city (or cities) included in that township's population total, if it is of a significant size 

See also
 List of people from McPherson County, Kansas
 National Register of Historic Places listings in McPherson County, Kansas
 McPherson Valley Wetlands
 Maxwell Wildlife Refuge

References

Notes

Further reading

 Wheeler, Wayne Leland  "An Analysis of Social Change in a Swedish-Immigrant Community: The Case of Lindsborg, Kansas " (PhD dissertation, University of Missouri-Columbia; ProQuest Dissertations Publishing, 1959  5905657) 

County
 Through the Years: A Pictorial History of McPherson County; McPherson Sentinel' Heritage House Publishing Co; 1992 
 McPherson County First Courthouse Built About 1869 or 1870; Lindsborg News-Record; March 30, 1959 
 Pioneer Life and Lore of McPherson County, Kansas; Edna Nyquist; Democratic-Opinion Press; 1932 
 A History of the Church of the Brethren in Kansas (includes McPherson College history); Elmer LeRoy Craik; McPherson Daily; Republican Press; 397 pages; 1922 
 Portrait and Biographical Record of Dickinson, Saline, McPherson, and Marion Counties, Kansas; Chapman Bros; 614 pages; 1893 
 Standard Atlas of McPherson County, Kansas; Geo  A  Ogle & Co; 82 pages; 1921 
 Plat Book of McPherson County, Kansas; North West Publishing Co; 50 pages; 1903 
 Edwards' Atlas of McPherson County, Kansas; John P  Edwards; 51 pages; 1884 

Trails
 The Story of the Marking of the Santa Fe Trail by the Daughters of the American Revolution in Kansas and the State of Kansas; Almira Cordry; Crane Co; 164 pages; 1915  (Download 4MB PDF eBook)
 The National Old Trails Road To Southern California, Part 1 (LA to KC); Automobile Club Of Southern California; 64 pages; 1916  (Download 6 8MB PDF eBook)

Mennonite Settlements
 Impact of Mennonite settlement on the cultural landscape of Kansas; Brenda Martin; Kansas State University; 1985/1988  
 Mennonite settlement : the relationship between the physical and cultural environment; Susan Movle; University of Utah; 1975/1886 
 Status of Mennonite women in Kansas in their church and home relationships; Eva Harshbarger; Bluffton College; 1925/1945 

External links

County
 
 McPherson County - Directory of Public Officials
Historical
 , from Hatteberg's People'' on KAKE TV news
Maps
 McPherson County Maps: Current, Historic, KDOT
 Kansas Highway Maps: Current, Historic, KDOT
 Kansas Railroad Maps: Current, 1996, 1915, KDOT and Kansas Historical Society

 
Kansas counties
1867 establishments in Kansas
Populated places established in 1867



ground_truth: Wearable sensors.

prompt_front: Now, answer the following question based on the text below, only give me the answer and do not output any other words.

Question: What was the population of McPherson County according to the 2020 census?

Read the following text and answer briefly.

Context 4:  283 (52): 36655–36664  doi:10 1074/jbc M802761200  PMC 2605998  PMID 18836183  ^ Viegas, C  S ; Cavaco, S ; Neves, P  L ; Ferreira, A ; João, A ; Williamson, M  K ; Price, P  A ; Cancela, M  L ; Simes, D  C  (Dec 2009)  "Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications"  American Journal of Pathology  175 (6): 2288–2298  doi:10 2353/ajpath 2009 090474  PMC 2789615  PMID 19893032  ^ Hafizi, S ; Dahlbäck, B  (Dec 2006)  "Gas6 and protein S  Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily"  The FEBS Journal  273 (23): 5231–5244  doi:10 1111/j 1742-4658 2006 05529 x  PMID 17064312  ^ Kulman, J  D ; Harris, J  E ; Xie, L ; Davie, E  W  (May 2007)  "Proline-rich Gla protein 2 is a cell-surface vitamin K-dependent protein that binds to the transcriptional coactivator Yes-associated protein"  Proceedings of the National Academy of Sciences of the United States of America  104 (21): 8767–8772  doi:10 1073/pnas 0703195104  PMC 1885577  PMID 17502622  ^ "Vitamin K"  MedlinePlus  US National Library of Medicine, National Institutes of Health  Sep 2016  Retrieved 26 May 2009  ^ Conly, J; Stein, K  (Dec 1994)  "Reduction of vitamin K2 concentrations in human liver associated with the use of broad spectrum antimicrobials"  Clinical and Investigative Medicine  17 (6): 531–539  PMID 7895417  ^ Ferland, G ; Sadowski, J  A ; O'Brien, M  E  (Apr 1993)  "Dietary induced subclinical vitamin K deficiency in normal human subjects"  Journal of Clinical Investigation  91 (4): 1761–1768  doi:10 1172/JCI116386  PMC 288156  PMID 8473516  ^ Holden, R  M ; Morton, A  R ; Garland, J  S ; Pavlov, A ; Day, A  G ; Booth, S  L  (Apr 2010)  "Vitamins K and D status in stages 3-5 chronic kidney disease"  Clinical Journal of the American Society of Nephrology  5 (4): 590–597  doi:10 2215/CJN 06420909  PMC 2849681  PMID 20167683  ^ Hodges, S  J ; Pilkington, M  J ; Shearer, M  J ; Bitensky, L ; Chayen, J (Jan 1990)  "Age-related changes in the circulating levels of congeners of vitamin K2, menaquinone-7 and menaquinone-8"  Clinical Science  78 (1): 63–66  PMID 2153497  ^ "Vitamin K"  Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (PDF)  National Academy Press  2001  p  162–196  ^ Tolerable Upper Intake Levels For Vitamins And Minerals (PDF), European Food Safety Authority, 2006 ^ a b Rhéaume-Bleue, p  42
^ "Important information to know when you are taking: Warfarin (Coumadin) and Vitamin K" (PDF)  National Institutes of Health Clinical Center  ^ "Nutrition Facts and Information for Parsley, raw"  Nutritiondata com  Retrieved 21 Apr 2013  ^ "Nutrition facts, calories in food, labels, nutritional information and analysis"  Nutritiondata com  13 Feb 2008  Retrieved 21 Apr 2013  ^ "Vitamin K"  Vivo colostate edu  2 Jul 1999  Retrieved 21 Apr 2013  ^ "Vitamin K"  Micronutrient Data Centre  ^ Ikeda, Y ; Iki, M ; Morita, A ; Kajita, E ; Kagamimori, S ; Kagawa, Y ; Yoneshima, H  (May 2006)  "Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study"  Journal of Nutrition  136 (5): 1323–1328  PMID 16614424  ^ Katsuyama, H ; Ideguchi, S ; Fukunaga, M ; Saijoh, K ; Sunami, S  (Jun 2002)  "Usual dietary intake of fermented soybeans (Natto) is associated with bone mineral density in premenopausal women"  Journal of Nutritional Science and Vitaminology  48 (3): 207–215  doi:10 3177/jnsv 48 207  PMID 12350079  ^ Sano, M ; Fujita, H ; Morita, I ; Uematsu, H ; Murota, S  (Dec 1999)  "Vitamin K2 (menatetrenone) induces iNOS in bovine vascular smooth muscle cells: no relationship between nitric oxide production and gamma-carboxylation"  Journal of Nutritional Science and Vitaminology  45 (6): 711–723  doi:10 3177/jnsv 45 711  PMID 10737225  ^ Gast, G  C ; de Roos, N  M ; Sluijs, I ; Bots, M  L ; Beulens, J  W ; Geleijnse, J  M ; Witteman, J  C ; Grobbee, D  E ; Peeters, P  H ; van der Schouw, Y  T  (Sep 2009)  "A high menaquinone intake reduces the incidence of coronary heart disease"  Nutrition, Metabolism, and Cardiovascular Diseases  19 (7): 504–510  doi:10 1016/j numecd 2008 10 004  PMID 19179058  ^ Oldenburg, J ; Bevans, C  G ; Müller, C  R ; Watzka, M  (2006)  "Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle"  Antioxidants & Redox Signaling  8 (3–4): 347–353  doi:10 1089/ars 2006 8 347  PMID 16677080  ^ Suttie, J  W  (1985)  "Vitamin K-dependent carboxylase"  Annual Review of Biochemistry  54: 459–477  doi:10 1146/annurev bi 54 070185 002331  PMID 3896125  ^ Presnell, S  R ; Stafford, D  W  (Jun 2002)  "The vitamin K-dependent carboxylase"  Thrombosis and Haemostasis  87 (6): 937–946  PMID 12083499  ^ Stafford, D  W  (Aug 2005)  "The vitamin K cycle"  Journal of Thrombosis and Haemostasis  3 (8): 1873–1878  doi:10 1111/j 1538-7836 2005 01419 x  PMID 16102054  ^ Rhéaume-Bleue, p  79 
^ Whitlon, D  S ; Sadowski, J  A ; Suttie, J  W  (Apr 1978)  "Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition"  Biochemistry  17 (8): 1371–1377  doi:10 1021/bi00601a003  PMID 646989  ^ Terlau, H ; Olivera, B  M  (Jan 2004)  "Conus venoms: a rich source of novel ion channel-targeted peptides"  Physiological Reviews  84 (1): 41–68  doi:10 1152/physrev 00020 2003  PMID 14715910  ^ Buczek, O ; Bulaj, G ; Olivera, BM (Dec 2005)  "Conotoxins and the posttranslational modification of secreted gene products"  Cellular and Molecular Life Sciences  62 (24): 3067–3079  doi:10 1007/s00018-005-5283-0  PMID 16314929  ^ "Prothrombin Time"  WebMD  ^ Dituri, F ; Buonocore, G ; Pietravalle, A ; Naddeo, F ; Cortesi, M; Pasqualetti, P; Tataranno M  L ; R , Agostino (Sep 2012)  "PIVKA-II plasma levels as markers of subclinical vitamin K deficiency in term infants"  Journal of Maternal, Fetal & Neonatal Medicine  25 (9): 1660–1663  doi:10 3109/14767058 2012 657273  PMID 22280352  ^ Thane, C  W ; Bates, C  J ; Shearer, M  J ; Unadkat, N; Harrington, D  J ; Paul, A  A ; Prentice, A ; Bolton-Smith, C  (Jun 2002)  "Plasma phylloquinone (vitamin K1) concentration and its relationship to intake in a national sample of British elderly people"  British Journal of Nutrition  87 (6): 615–622  doi:10 1079/BJNBJN2002582  PMID 12067432  ^ McKeown, N  M ; Jacques, P  F ; Gundberg, C  M ; Peterson, J  W ; Tucker, K  L ; Kiel, D  P ; Wilson, P  W ; Booth, SL (Jun 2002)  "Dietary and nondietary determinants of vitamin K biochemical measures in men and women" (PDF)  Journal of Nutrition  132 (6): 1329–1334  PMID 12042454  ^ Yamano, M ; Yamanaka, Y ; Yasunaga, K ; Uchida, K  (Sep 1989)  "Effect of vitamin K deficiency on urinary gamma-carboxyglutamic acid excretion in rats"  Nihon Ketsueki Gakkai Zasshi  52 (6): 1078–1086  PMID 2588957  ^ Matsumoto, T ; Miyakawa, T ; Yamamoto, D  (Mar 2012)  "Effects of vitamin K on the morphometric and material properties of bone in the tibiae of growing rats"  Metabolism  61 (3): 407–414  doi:10 1016/j metabol 2011 07 018  PMID 21944271  ^ Je, S -H ; Joo, N -S ; Choi, B -H ; Kim, K -M ; Kim, B -T ; Park, S -B ; Cho, D -Y ; Kim, K -N ; Lee, D -J  (Aug 2011)  "Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral density in Korean postmenopausal women over sixty-years-old"  Journal of Korean Medical Science  26 (8): 1093–1098  doi:10 3346/jkms 2011 26 8 1093  PMC 3154347  PMID 21860562  ^ Bentley, R ; Meganathan, R  (Sep 1982)  "Biosynthesis of vitamin K (menaquinone) in bacteria" (PDF)  Microbiological Reviews  46 (3): 241–280  PMC 281544  PMID 6127606  ^ Haddock, B  A ; Jones, C  W  (Mar 1977)  "Bacterial respiration" (PDF)  Bacteriological Reviews  41 (1): 47–99  PMC 413996  PMID 140652  ^ Shearer, M  J  (Jan 1995)  "Vitamin K"  Lancet  345 (8944): 229–234  doi:10 1016/S0140-6736(95)90227-9  PMID 7823718  ^ Greer, J  P ; Foerster, J ; Lukens, J  N ; Rodgers, G  M ; Paraskevas, F ; Glader, B  (eds )  Wintrobe's Clinical Hematology (11th ed )  Philadelphia, Pennsylvania: Lippincott, Williams and Wilkens  ^ a b American Academy of Pediatrics Committee on Fetus Newborn  (Jul 2003)  "Controversies concerning vitamin K and the newborn  American Academy of Pediatrics Committee on Fetus and Newborn" (PDF)  Pediatrics  112 (1 1): 191–192  doi:10 1542/peds 112 1 191  PMID 12837888  ^ Logan, S ; Gilbert, R  (1998)  "Vitamin K For Newborn Babies" (PDF)  Department of Health  Retrieved 12 Oct 2014  ^ "Postnatal care: Routine postnatal care of women and their babies [CG37]"  www nice org uk  NICE  Jul 2006  Retrieved 12 Oct 2014  ^ Parker, L ; Cole, M ; Craft, A  W ; Hey, E  N  (1998)  "Neonatal vitamin K administration and childhood cancer in the north of England: retrospective case-control study"  BMJ (Clinical Research Edition)  316 (7126): 189–193  doi:10 1136/bmj 316 7126 189  PMC 2665412  PMID 9468683  ^ McMillan, D  D  (1997)  "Routine administration of vitamin K to newborns"  Paediatric Child Health  2 (6): 429–431  ^ "Newborns get rare disorder after parents refused shots"  Having four cases since February just at Vanderbilt was a little bit concerning to me ^ Dam, C  P  H  (1935)  "The Antihaemorrhagic Vitamin of the Chick: Occurrence And Chemical Nature"  Nature  135 (3417): 652–653  doi:10 1038/135652b0  ^ Dam, C  P  H  (1941)  "The discovery of vitamin K, its biological functions and therapeutical application" (PDF)  Nobel Prize Laureate Lecture  ^ McAlister, V  C  (2006)  "Control of coagulation: a gift of Canadian agriculture" (PDF)  Clinical and Investigative Medicine  29 (6): 373–377  ^ MacCorquodale, D  W ; Binkley, S  B ; Thayer, S  A ; Doisy, E  A  (1939)  "On the constitution of Vitamin K1"  Journal of the American Chemical Society  61 (7): 1928–1929  doi:10 1021/ja01876a510  ^ Fieser, L  F  (1939)  "Synthesis of Vitamin K1"  Journal of the American Chemical Society  61 (12): 3467–3475  doi:10 1021/ja01267a072  ^ Dam, C  P  H  (12 Dec 1946)  "The discovery of vitamin K, its biological functions and therapeutical application" (PDF)  Nobel Prize lecture  ^ Warner, E  D ; Brinkhous, K  M ; Smith, H  P  (1938)  "Bleeding Tendency of Obstructive Jaundice"  Proceedings of the Society of Experimental Biology and Medicine  37 (4): 628–630  doi:10 3181/00379727-37-9668P  ^ Stenflo, J; Fernlund, P ; Egan, W ; Roepstorff, P  (Jul 1974)  "Vitamin K dependent modifications of glutamic acid residues in prothrombin"  Proceedings of the National Academy of Sciences of the United States of America  71 (7): 2730–2733  doi:10 1073/pnas 71 7 2730  PMC 388542  PMID 4528109  ^ Nelsestuen, G  L ; Zytkovicz, T  H ; Howard, J  B  (Oct 1974)  "The mode of action of vitamin K  Identification of gamma-carboxyglutamic acid as a component of prothrombin" (PDF)  Journal of Biological Chemistry  249 (19): 6347–6350  PMID 4214105  ^ Magnusson, S ; Sottrup-Jensen, L ; Petersen, T  E ; Morris, H  R ; Dell, A  (Aug 1974)  "Primary structure of the vitamin K-dependent part of prothrombin"  FEBS Letters  44 (2): 189–193  doi:10 1016/0014-5793(74)80723-4  PMID 4472513  Bibliography[edit]
Rhéaume-Bleue, Kate (2012)  Vitamin K2 and the Calcium Paradox  John Wiley & Sons, Canada  ISBN 1-118-06572-7  External links[edit]
"Vitamin K: Another Reason to Eat Your Greens"  v
TPP / ThDP (B1)
FMN, FAD (B2)
NAD+, NADH, NADP+, NADPH (B3)
Coenzyme A (B5)
PLP / P5P (B6)
THFA / H4FA, DHFA / H2FA, MTHF (B9)
AdoCbl, MeCbl (B12)
Phylloquinone (K1), Menaquinone (K2)
non-vitamins
Coenzyme B
Heme / Haem (A, B, C, O)
Molybdopterin/Molybdenum cofactor
THMPT / H4MPT
Fe2+, Fe3+
vitamins: see vitamins
Antihemorrhagics (B02)
(coagulation)
Phytomenadione (K1)
Menadione (K3)
intrinsic: IX/Nonacog alfa
VIII/Moroctocog alfa/Turoctocog alfa
extrinsic: VII/Eptacog alfa
common: X
II/Thrombin
I/Fibrinogen
XIII/Catridecacog
combinations: Prothrombin complex concentrate (II, VII, IX, X, protein C and S)
Carbazochrome
thrombopoietin receptor agonist (Romiplostim
Eltrombopag)
Tetragalacturonic acid hydroxymethylester
Epinephrine/Adrenalone
amino acids (Aminocaproic acid
Aminomethylbenzoic acid)
serpins (Aprotinin
Alfa1 antitrypsin
Camostat) 



ground_truth: 30,223.