Fig. 7. Chemical synthesis of TLN648. Reagents and conditions: ( A ) InCl 3  (5 mol %), acetone, 56 °C, 24 to 72 h; ( B ) 1 M HCl in diethyl ether (1 equiv), acetonitrile, room temperature, 5 to 10 min; ( C ) dicyandiamide (1.01 equiv), ethanol, H 2 O, reflux, 18 h.