Figure 2 Axial T2w images and Sagittal T1w at the Midline MRI shows diffuse hypomyelination with a slight hyperintense T2-signal throughout the white matter, stable at different ages. On sagittal images, corpus callosum is very thin. Basal ganglia are normal. Both supratentorial and infratentorial white matter are affected, note the involvement of cortico spinal tract (arrow), the medial lemniscus (arrow head), and the caudate tail (open arrow) well contrasted by adjacent hypomyelinated white matter.