Fig. 2 HIV-1 infection induces damage on cytokine and chemokine networks formed by alternative MDMs that are not restored even under HAART. The analysis of correlation between the cytokines and chemokines released by unstimulated, LPS- or β-glucan-stimulated alternative MDMs was performed using Spearman's two-tailed test. The network was built using Cytoscape software (v3.2.0). Solid lines indicate strong correlations and dash-dot lines are representative of moderate correlations. All the black lines represent positive correlation between the targets and the red lines are representative of negative correlations.