Figure 1 Histological examination of SI-induced retina damage in SD rats, C57BL/6J and BALB/C mice. Animals were peritoneally (i.p.) injected with SI (50 mg/kg). (A) Representative images of normal and SI-damaged retinas of SD rats at Week 1 and Week 2, post SI injection. (B) ONL disorganization in SI-damaged retina of SD rats at Week 2. (C) Normal and SI-damaged retinas of C57BL/6J mice at Week 1 and Week 3. (D) ONL disorganization of SI-damaged retinas of C57BL/6J mice at Week 1. (E) Normal and SI-damaged retinas of BLAB/C mice at Week 1 and Week 3. (F) ONL disorganization of SI-damaged retinas of BLAB/C mice at Week 1. All boxed areas in (A-F) are shown with 3× magnification, below each image. Asterisks (A-F) indicate ONL disorganization. Arrows (A,C,E) indicate swelled RPE cells. Orange arrow heads at the left side (A,C,E) indicate the OLM. Toluidine blue (A,B) and hematoxylin and eosin (H&E) staining (C-F). Scale bars: 50 μm in (A,C,E); 200 μm in (B,D,F). SI, sodium iodate; SD, Sprague-Dawley; RPE, retina pigment epithelium; OS, outer segment; IS, inner segment; ONL, outer nuclear layer; OLM, outer limiting membrane.