
 Fig . 9. Mutational analysis in BPXV-P60-SB239063 and BPXV-P60-Control viruses. Whole genome sequences of BPXV-P60-SB239063 and BPXV-P60-Control viruses were compared with BPXV P0 virus to identify the mutations in the passaged viruses ( A ). Resistance-associated (SB239063-resistant) mutations were identified by comparing the genome of BPXV-P60-SB239063 and BPXV-P60-Control. Two unique mutations, one nonsynonymous mutation (C201Y) in the coding region of Ribonucleoside-diphosphate reductase ( B ) and one point mutation (C-A) in the promoter region of Ser/Thr kinase ( C ) were identified in BPXV-P60-SB239063 as compared to BPXV-P60-Control.