
 Fig . 8. Resistant virus switches its preference to utilize p38-Υ. p38-α KO, p38-Υ KO or WT Vero cells, in triplicates, were infected with BPXV P0, BPXV-P60-SB239063 or BPXV-P60-Control viruses at an MOI of 0.1. Infectious progeny virus particles released at 48 hpi were quantified by plaque assay ( A ). The viral titers were further analyzed to determine fold-suppression in KO cells (p38-α KO or p38-Y KO) as compared to the WT Vero cells. Fold suppression of P0 ( B ), P60-Control ( C ) and P60-SB239063 ( D ) virus is shown. Error bars indicate SD. Pair-wise statistical comparisons were performed using Student’s  t -test. (*** =  P  < 0.001). Values are means ± SD and representative of the result of at least three independent experiments.