Fig. 7 Thrombotic Pathways Leading to Atheroma Calcification.  Classical coagulation pathways converge to a common thrombin-activated fibrinogenic clot formation, which is regulated by a set of serine proteases or coagulation factors. Thrombin also activates the PAR-1/PAR-4 pathway, which in conjunction with lipoxides and inflammatory stimuli converts resting leukocytes to the activated state in platelet-rich-plasma. Both coagulation mechanisms result in thrombotic plaque development, rupture, and ACVD complications. Figure generated using the ‘Coagulation Cascade’ template from  BioRender . LT – leukotriene; PAR – protease activated receptor; TX – thromboxane. Fig. 7