Figure 3. Biochemical responses in patients with  RET -mutant
MTC included in the PAS: (a) calcitonin and (b) CEA. *Biochemical response evaluable populations comprised
 RET -mutant MTC patients in the PAS with
abnormal baseline levels of calcitonin or CEA, respectively $ CR was defined as normalization of serum levels following
treatment; PR was ⩾ 50% decrease from baseline serum levels; SD was
between +50% and −50% change from baseline serum levels; progressive
disease was ⩾ 50% increase from baseline serum levels; maintained
for a minimum of 4 weeks. Objective biochemical response rate was
defined as the proportion of patients achieving a complete or
partial biochemical response. CI was calculated using the
Clopper–Pearson method. CEA, carcinoembryonic antigen; CI, confidence interval; CR, complete
response; MTC, medullary thyroid cancer; PAS, primary analysis set;
PR, partial response; RET, REarranged during Transfection; SD,
stable disease.