Timbrt/Liver-Text-OA huggingface dataset:
Question: What are the genetic changes related to ataxia with vitamin E deficiency ?
Answer: Mutations in the TTPA gene cause ataxia with vitamin E deficiency. The TTPA gene provides instructions for making the -tocopherol transfer protein (TTP), which is found in the liver and brain. This protein controls distribution of vitamin E obtained from the diet (also called -tocopherol) to cells and tissues throughout the body. Vitamin E helps cells prevent damage that might be done by free radicals.  TTPA gene mutations impair the activity of the TTP protein, resulting in an inability to retain and use dietary vitamin E. As a result, vitamin E levels in the blood are greatly reduced and free radicals accumulate within cells. Nerve cells (neurons) in the brain and spinal cord (central nervous system) are particularly vulnerable to the damaging effects of free radicals and these cells die off when they are deprived of vitamin E. Nerve cell damage can lead to problems with movement and other features of ataxia with vitamin E deficiency.
Question: What is (are) Gallbladder Cancer ?
Answer: Key Points
                    - Gallbladder cancer is a disease in which malignant (cancer) cells form in the tissues of the gallbladder.    - Being female can increase the risk of developing gallbladder cancer.     - Signs and symptoms of gallbladder cancer include jaundice, fever, and pain.     - Gallbladder cancer is difficult to detect (find) and diagnose early.     - Tests that examine the gallbladder and nearby organs are used to detect (find), diagnose, and stage gallbladder cancer.     - Certain factors affect the prognosis (chance of recovery) and treatment options.
                
                
                    Gallbladder cancer is a disease in which malignant (cancer) cells form in the tissues of the gallbladder.
                    Gallbladder cancer is a rare disease in which malignant (cancer) cells are found in the tissues of the gallbladder. The gallbladder is a pear-shaped organ that lies just under the liver in the upper abdomen. The gallbladder stores bile, a fluid made by the liver to digest fat. When food is being broken down in the stomach and intestines, bile is released from the gallbladder through a tube called the common bile duct, which connects the gallbladder and liver to the first part of the small intestine.      The wall of the gallbladder has 3 main layers of tissue.          -  Mucosal (inner) layer.    - Muscularis (middle, muscle) layer.     -  Serosal (outer) layer.        Between these layers is supporting connective tissue. Primary gallbladder cancer starts in the inner layer and spreads through the outer layers as it grows.
                
                
                    Gallbladder cancer is difficult to detect (find) and diagnose early.
                    Gallbladder cancer is difficult to detect and diagnose for the following reasons:         - There are no signs or symptoms in the early stages of gallbladder cancer.    - The symptoms of gallbladder cancer, when present, are like the symptoms of many other illnesses.    - The gallbladder is hidden behind the liver.         Gallbladder cancer is sometimes found when the gallbladder is removed for other reasons. Patients with gallstones rarely develop gallbladder cancer.
Question: What is (are) Langerhans Cell Histiocytosis ?
Answer: Key Points
                    - Langerhans cell histiocytosis is a type of cancer that can damage tissue or cause lesions to form in one or more places in the body.    - Family history or having a parent who was exposed to certain chemicals may increase the risk of LCH.    - The signs and symptoms of LCH depend on where it is in the body.         - Skin and nails     - Mouth     - Bone     - Lymph nodes and thymus     - Endocrine system      - Central nervous system (CNS)     - Liver and spleen     - Lung     - Bone marrow        - Tests that examine the organs and body systems where LCH may occur are used to detect (find) and diagnose LCH.    - Certain factors affect prognosis (chance of recovery) and treatment options.
                
                
                    Langerhans cell histiocytosis is a type of cancer that can damage tissue or cause lesions to form in one or more places in the body.
                    Langerhans cell histiocytosis (LCH) is a rare cancer that begins in LCH cells (a type of dendritic cell which fights infection). Sometimes there are mutations (changes) in LCH cells as they form. These include mutations of the  BRAF  gene. These changes may make the LCH cells grow and multiply quickly. This causes LCH cells to build up in certain parts of the body, where they can damage tissue or form lesions.    LCH is not a disease of the Langerhans cells that normally occur in the skin.   LCH may occur at any age, but is most common in young children. Treatment of LCH in children is different from treatment of LCH in adults. The treatments for LCH in children and adults are described in separate sections of this summary.   Check the list of NCI-supported cancer clinical trials that are now accepting patients with childhood Langerhans cell histiocytosis. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI website.
Question: What is the outlook for Langerhans Cell Histiocytosis ?
Answer: LCH in organs such as the skin, bones, lymph nodes, or pituitary gland usually gets better with treatment and is called "low- risk". LCH in the spleen, liver, or bone marrow is harder to treat and is called "high-risk".    The prognosis (chance of recovery) and treatment options depend on the following:          - Whether there are mutations of the BRAF gene.    - How old the patient is when diagnosed with LCH.    - How many organs or body systems the cancer affects.    - Whether the cancer is found in the liver, spleen, bone marrow, or certain bones in the skull.    - How quickly the cancer responds to initial treatment.    - Whether the cancer has just been diagnosed or has come back (recurred).        In infants up to one year of age, LCH may go away without treatment.
Question: What are the stages of Langerhans Cell Histiocytosis ?
Answer: Key Points
                    - There is no staging system for Langerhans cell histiocytosis (LCH).    - Treatment of LCH is based on where LCH cells are found in the body and how many body systems are affected.
                
                
                    There is no staging system for Langerhans cell histiocytosis (LCH).
                    The extent or spread of cancer is usually described as stages. There is no staging system for LCH.
                
                
                    Treatment of LCH is based on where LCH cells are found in the body and how many body systems are affected.
                    LCH is described as single-system disease or multisystem disease, depending on how many body systems are affected:          -  Single-system LCH: LCH is found in one part of an organ or body system (unifocal) or in more than one part of that organ or body system (multifocal). Bone is the most common single place for LCH to be found.    -  Multisystem LCH: LCH occurs in two or more organs or body systems or may be spread throughout the body. Multisystem LCH is less common than single-system LCH.        LCH may affect low-risk organs or high-risk organs:         -  Low-risk organs include the skin, bone, lungs, lymph nodes, gastrointestinal tract, pituitary gland, and central nervous system (CNS).    -  High-risk organs include the liver, spleen, and bone marrow.
Question: What is (are) Primary Myelofibrosis ?
Answer: Key Points
                    - Primary myelofibrosis is a disease in which abnormal blood cells and fibers build up inside the bone marrow.    - Symptoms of primary myelofibrosis include pain below the ribs on the left side and feeling very tired.    - Certain factors affect prognosis (chance of recovery) and treatment options for primary myelofibrosis.
                
                
                    Primary myelofibrosis is a disease in which abnormal blood cells and fibers build up inside the bone marrow.
                    The bone marrow is made of tissues that make blood cells (red blood cells, white blood cells, and platelets) and a web of fibers that support the blood-forming tissues. In primary myelofibrosis (also called chronic idiopathic myelofibrosis), large numbers of blood stem cells become blood cells that do not mature properly (blasts). The web of fibers inside the bone marrow also becomes very thick (like scar tissue) and slows the blood-forming tissues ability to make blood cells. This causes the blood-forming tissues to make fewer and fewer blood cells. In order to make up for the low number of blood cells made in the bone marrow, the liver and spleen begin to make the blood cells.
Question: How to diagnose Myelodysplastic/ Myeloproliferative Neoplasms ?
Answer: Tests that examine the blood and bone marrow are used to detect (find) and diagnose myelodysplastic/myeloproliferative neoplasms. The following tests and procedures may be used:         -   Physical exam and history : An exam of the body to check general signs of health, including checking for signs of disease such as an enlarged spleen and liver. A history of the patients health habits and past illnesses and treatments will also be taken.     -   Complete blood count (CBC) with differential : A procedure in which a sample of blood is drawn and checked for the following:                - The number of red blood cells and platelets.       - The number and type of white blood cells.      - The amount of hemoglobin (the protein that carries oxygen) in the red blood cells.       - The portion of the sample made up of red blood cells.              -   Peripheral blood smear : A procedure in which a sample of blood is checked for blast cells, the number and kinds of white blood cells, the number of platelets, and changes in the shape of blood cells.    -   Blood chemistry studies : A procedure in which a blood sample is checked to measure the amounts of certain substances released into the blood by organs and tissues in the body. An unusual (higher or lower than normal) amount of a substance can be a sign of disease.     -   Bone marrow aspiration and biopsy : The removal of a small piece of bone and bone marrow by inserting a needle into the hipbone or breastbone. A pathologist views both the bone and bone marrow samples under a microscope to look for abnormal cells.  The following tests may be done on the sample of tissue that is removed:               -  Cytogenetic analysis : A test in which cells in a sample of blood or bone marrow are viewed under a microscope to look for certain changes in the chromosomes. The cancer cells in myelodysplastic/myeloproliferative neoplasms do not contain the Philadelphia chromosome that is present in chronic myelogenous leukemia.      -  Immunocytochemistry : A test that uses antibodies to check for certain antigens in a sample of bone marrow. The antibody is usually linked to a radioactive substance or a dye that causes the cells in the sample to light up under a microscope. This type of test is used to tell the difference between myelodysplastic/myeloproliferative neoplasms, leukemia, and other conditions.
Question: What is (are) Liver (Hepatocellular) Cancer ?
Answer: Key Points
                    - Liver cancer is a disease in which malignant (cancer) cells form in the tissues of the liver.    - Liver cancer is less common in the United States than in other parts of the world.    - Having hepatitis or cirrhosis can increase the risk of developing liver cancer.
                
                
                    Liver cancer is a disease in which malignant (cancer) cells form in the tissues of the liver.
                    The liver is one of the largest organs in the body. It has four lobes and fills the upper right side of the abdomen inside the rib cage. Three of the many important functions of the liver are:         - To filter harmful substances from the blood so they can be passed from the body in stools and urine.    - To make bile to help digest fats from food.    - To store glycogen (sugar), which the body uses for energy.         See the following PDQ summaries for more information about liver (hepatocellular) cancer:         -  Liver (Hepatocellular) Cancer Prevention     -  Adult Primary Liver Cancer Treatment     -  Childhood Liver Cancer Treatment
                
                
                    Liver cancer is less common in the United States than in other parts of the world.
                    Liver cancer is uncommon in the United States, but is the fourth most common cancer in the world. In the United States, men, especially Chinese American men, have a greater risk of developing liver cancer.
Question: Who is at risk for Liver (Hepatocellular) Cancer? ?
Answer: Having hepatitis or cirrhosis can increase the risk of developing liver cancer. Anything that increases the chance of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer. People who think they may be at risk should discuss this with their doctor. Risk factors for liver cancer include:         - Having hepatitis B or hepatitis C; having both hepatitis B and hepatitis C increases the risk even more.    - Having cirrhosis, which can be caused by:                -  hepatitis (especially hepatitis C); or      - drinking large amounts of alcohol for many years or being an alcoholic.             - Eating foods tainted with aflatoxin (poison from a fungus that can grow on foods, such as grains and nuts, that have not been stored properly).
Question: Who is at risk for Bile Duct Cancer (Cholangiocarcinoma)? ?
Answer: Having colitis or certain liver diseases can increase the risk of bile duct cancer. Anything that increases your risk of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer. People who think they may be at risk should discuss this with their doctor.    Risk factors for bile duct cancer include the following conditions:         - Primary sclerosing cholangitis (a progressive disease in which the bile ducts become blocked by inflammation and scarring).    -  Chronic ulcerative colitis.    -  Cysts in the bile ducts (cysts block the flow of bile and can cause swollen bile ducts, inflammation, and infection).    - Infection with a Chinese liver fluke parasite.
Question: What are the symptoms of Bile Duct Cancer (Cholangiocarcinoma) ?
Answer: Signs of bile duct cancer include jaundice and pain in the abdomen. These and other signs and symptoms may be caused by bile duct cancer or by other conditions. Check with your doctor if you have any of the following:         -  Jaundice (yellowing of the skin or whites of the eyes).    - Dark urine.    - Clay colored stool.    - Pain in the abdomen.    -  Fever.    - Itchy skin.    -  Nausea and vomiting.    - Weight loss for an unknown reason.
Question: What is (are) Extragonadal Germ Cell Tumors ?
Answer: Key Points
                    - Extragonadal germ cell tumors form from developing sperm or egg cells that travel from the gonads to other parts of the body.    - Age and gender can affect the risk of extragonadal germ cell tumors.     - Signs and symptoms of extragonadal germ cell tumors include breathing problems and chest pain.     - Imaging and blood tests are used to detect (find) and diagnose extragonadal germ cell tumors.    - Certain factors affect prognosis (chance of recovery) and treatment options.
                
                
                    Extragonadal germ cell tumors form from developing sperm or egg cells that travel from the gonads to other parts of the body.
                    " Extragonadal" means outside of the gonads (sex organs). When cells that are meant to form sperm in the testicles or eggs in the ovaries travel to other parts of the body, they may grow into extragonadal germ cell tumors. These tumors may begin to grow anywhere in the body but usually begin in organs such as the pineal gland in the brain, in the mediastinum (area between the lungs), or in the retroperitoneum (the back wall of the abdomen).     Extragonadal germ cell tumors can be benign (noncancer) or malignant (cancer). Benign extragonadal germ cell tumors are called benign teratomas. These are more common than malignant extragonadal germ cell tumors and often are very large.   Malignant extragonadal germ cell tumors are divided into two types, nonseminoma and seminoma. Nonseminomas tend to grow and spread more quickly than seminomas. They usually are large and cause signs and symptoms. If untreated, malignant extragonadal germ cell tumors may spread to the lungs, lymph nodes, bones, liver, or other parts of the body.   For information about germ cell tumors in the ovaries and testicles, see the following PDQ summaries:         -  Ovarian Germ Cell Tumors Treatment     -  Testicular Cancer Treatment
Question: What are the symptoms of Gastrointestinal Carcinoid Tumors ?
Answer: Some gastrointestinal carcinoid tumors have no signs or symptoms in the early stages.Signs and symptoms may be caused by the growth of the tumor and/or the hormones the tumor makes. Some tumors, especially tumors of the stomach or appendix, may not cause signs or symptoms. Carcinoid tumors are often found during tests or treatments for other conditions.    Carcinoid tumors in the small intestine (duodenum, jejunum, and ileum), colon, and rectum sometimes cause signs or symptoms as they grow or because of the hormones they make. Other conditions may cause the same signs or symptoms. Check with your doctor if you have any of the following:         -  Duodenum  Signs and symptoms of GI carcinoid tumors in the duodenum (first part of the small intestine, that connects to the stomach) may include the following:                  -  Abdominal pain.       -  Constipation.       -  Diarrhea.       - Change in stool color.       -  Nausea.       -  Vomiting.       -  Jaundice (yellowing of the skin and whites of the eyes).       - Heartburn.                -  Jejunum and ileum  Signs and symptoms of GI carcinoid tumors in the jejunum (middle part of the small intestine) and ileum (last part of the small intestine, that connects to the colon) may include the following:                  -  Abdominal pain.       - Weight loss for no known reason.       - Feeling very tired.       - Feeling bloated       -  Diarrhea.       -  Nausea.       - Vomiting.                -  Colon  Signs and symptoms of GI carcinoid tumors in the colon may include the following:                  - Abdominal pain.       - Weight loss for no known reason.                -  Rectum  Signs and symptoms of GI carcinoid tumors in the rectum may include the following:                  -  Blood in the stool.       - Pain in the rectum.       -  Constipation.
Question: what research (or clinical trials) is being done for Liver (Hepatocellular) Cancer ?
Answer: Cancer prevention clinical trials are used to study ways to prevent cancer.
                    Cancer prevention clinical trials are used to study ways to lower the risk of developing certain types of cancer. Some cancer prevention trials are conducted with healthy people who have not had cancer but who have an increased risk for cancer. Other prevention trials are conducted with people who have had cancer and are trying to prevent another cancer of the same type or to lower their chance of developing a new type of cancer. Other trials are done with healthy volunteers who are not known to have any risk factors for cancer.    The purpose of some cancer prevention clinical trials is to find out whether actions people take can prevent cancer. These may include eating fruits and vegetables, exercising, quitting smoking, or taking certain medicines, vitamins, minerals, or food supplements.
                
                
                    New ways to prevent liver cancer are being studied in clinical trials.
                    Clinical trials are taking place in many parts of the country. Information about clinical trials can be found in the Clinical Trials section of the NCI website. Check NCI's list of cancer clinical trials for liver cancer prevention trials that are now accepting patients.
Question: What is (are) Neuroblastoma ?
Answer: Key Points
                    - Neuroblastoma is a disease in which malignant (cancer) cells form in neuroblasts (immature nerve tissue) in the adrenal gland, neck, chest, or spinal cord.    - Neuroblastoma is sometimes caused by a gene mutation (change) passed from the parent to the child.    - Signs and symptoms of neuroblastoma include bone pain and a lump in the abdomen, neck, or chest.     - Tests that examine many different body tissues and fluids are used to detect (find) and diagnose neuroblastoma.    - A biopsy is done to diagnose neuroblastoma.    - Certain factors affect prognosis (chance of recovery) and treatment options.
                
                
                    Neuroblastoma is a disease in which malignant (cancer) cells form in neuroblasts (immature nerve tissue) in the adrenal gland, neck, chest, or spinal cord.
                    Neuroblastoma often begins in the nerve tissue of the adrenal glands. There are two adrenal glands, one on top of each kidney in the back of the upper abdomen. The adrenal glands make important hormones that help control heart rate, blood pressure, blood sugar, and the way the body reacts to stress. Neuroblastoma may also begin in nerve tissue in the neck, chest, abdomen or pelvis.      Neuroblastoma most often begins in infancy and may be diagnosed in the first month of life. It is found when the tumor begins to grow and cause signs or symptoms. Sometimes it forms before birth and is found during a fetal ultrasound.   By the time neuroblastoma is diagnosed, the cancer has usually metastasized (spread). Neuroblastoma spreads most often to the lymph nodes, bones, bone marrow, and liver. In infants, it also spreads to the skin.
Question: What is (are) Pancreatic Cancer ?
Answer: Key Points
                    - Pancreatic cancer is a disease in which malignant (cancer) cells form in the tissues of the pancreas.    - Smoking and health history can affect the risk of pancreatic cancer.    - Signs and symptoms of pancreatic cancer include jaundice, pain, and weight loss.    - Pancreatic cancer is difficult to detect (find) and diagnose early.    - Tests that examine the pancreas are used to detect (find), diagnose, and stage pancreatic cancer.    - Certain factors affect prognosis (chance of recovery) and treatment options.
                
                
                    Pancreatic cancer is a disease in which malignant (cancer) cells form in the tissues of the pancreas.
                    The pancreas is a gland about 6 inches long that is shaped like a thin pear lying on its side. The wider end of the pancreas is called the head, the middle section is called the body, and the narrow end is called the tail. The pancreas lies between the stomach and the spine.     The pancreas has two main jobs in the body:         - To make juices that help digest (break down) food.    - To make hormones, such as insulin and glucagon, that help control blood sugar levels. Both of these hormones help the body use and store the energy it gets from food.         The digestive juices are made by exocrine pancreas cells and the hormones are made by endocrine pancreas cells. About 95% of pancreatic cancers begin in exocrine cells.   This summary is about exocrine pancreatic cancer. For information on endocrine pancreatic cancer, see the PDQ summary on Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment.   For information on pancreatic cancer in children, see the PDQ summary on Unusual Cancers of Childhood Treatment.