乔春华

苏州大学教授
乔春华,苏州大学药学院，特聘教授，博士生导师，合成药物化学教研室主任·
研究方向：1）对耐药菌敏感核苷类抗结核药物的研究；2）抗细胞凋亡Bcl-2蛋白抑制剂的设计、合成与评价。3）抗寄生虫药物的设计与合成研究。
人物经历
教育简历
1989.9-1993.7东北师范大学化学系，学士学位（化学），吉林长春
1993.8-1996.7北京师范大学化学系，硕士学位（有机化学），北京
1999.9-2004.8美国凯斯西部保留地大学（Case Western Reserve University）化学系,博士学位（有机化学）
工作简历
1996.8-1999.7中国科学院北京化学研究所，研究助理，北京
2004.9-2005.4美国密执根大学（University of Michigan）化学系，博士后
2005.5-2007,12美国明尼苏达大学（University of Minnesota）药物设计中心，博士后
2008,2-苏州大学药学院，特聘教授，博士生导师，合成药物化学教研室主任。
研究方向
1）对耐药菌敏感核苷类抗结核药物的研究；2）抗细胞凋亡Bcl-2蛋白抑制剂的设计、合成与评价。3）抗寄生虫药物的设计与合成研究。
主要贡献
发表论文
1XingYan, Jinglei Chen, Chunhua Qiao* Phosphomolybdic Acid Catalyzed Synthesis of 1,2,4,5-Tetraoxanes,Syn Lett. Accepted
2Wei Yin, Chunhua Qiao* Synthesis of Epigoitrin from (R)-(+)-4-Hydroxy-γ-butyrolactone，J. Hetercyl.Chem. Accepted.
3Zhaoli Zhang, Jinglei Chen, Qiongming Xu，Chunhua Qiao*Efficient Synthesis of Hydroxytyrosol from 3,4-Dihydroxybenzaldehyde.Synth. Commun. In press.
4Chunhua Qiao, Amol Gulpte, Helena Boshoff, Daniel J. Wilson, Eric Bennett,Clifton E. Barry III, and Courtney C. Aldrich,“5’-O-[(N-Acyl)sulfamoyl]adenosines as Antitubercular Agents that Inhibit MbtA: An Adenylation Enzyme Required for Siderophore Biosynthesis of the Mycobactins.J. Med.Chem.2007,50, 6080-6094.
5Chunhua Qiao, Daniel J. Wilson,Eric Bennett, and Courtney C. Aldrich,“A Mechanism-Based Aryl Carrier Protein/Thiolation Domain Affinity Probe”J. Am. Chem. Soc.2007,129, 6350-6351.
6Chunhua Qiao, Daniel J. Wilson,Eric Bennett, and Courtney C. Aldrich,“A Mechanism-Based Aryl Carrier Protein/Thiolation Domain Affinity Probe”J. Am. Chem. Soc.2007,129, 6350-6351
5Chunhua Qiao,Ke-Qing Ling, Eric M. Shepard, David M. Dooley, and Lawrence M. Sayre,“Mechanism-Based Cofactor Derivatization of a Copper Amine Oxidase by a Branched Primary Amine Recruits the Oxidase Activity of the Enzyme to Turn Inactivator into Substrate”J. Am. Chem. Soc.2006,128, 6206-6219
6Ravindranadh Somu, Helena Boshoff,Chunhua Qiao,Eric Bennett, Clifton E. Barry III, and Courtney C. Aldrich,“Rationally Designed Nucleoside Antibiotics that Inhibit Siderophore Biosynthesis ofMycobacterium tuberculosis”J. Med. Chem.2006,49, 31-34.
7Miri Yoon, Anjali Patwardhan,Chunhua Qiao,Steven O. Mansoorabadi, Ann L. Menefee, George H. Reed, and E. Neil G. Marsh,“Reaction of Adenosylcobalamin-Dependent Glutamate Mutase with 2-Thiolglutarate”Biochemistry,2006,45,11650-11657
8Chunhua Qiao,andE. Neil G. Marsh,“Mechanism of Benzylsuccinate Synthase: Stereochemistry of Toluene Addition to Fumarate and Maleate”J. Am. Chem. Soc.2005,127, 8608-8609
9Chunhua Qiao,Heung-Bae Jeon, and Lawrence M. Sayre,“Selective Inhibition of Plasma Amine Oxidase by Homopropargylamine, a New Inactivator Motif”J. Am. Chem. Soc.2004,126,8038-8045
10Zbynek Lamplot, Marek Sebela, Michal Malon, Rene Lenobel, Karel Lemr, Jan Havlis, Pavel Pec,Chunhua Qiao, Lawrence M. Sayre,“1,5-Diamino-2-pentyne is both a substrate and inactivator of plant copper amine oxidases”Eur. J. Biochem.,2004, 271(23/24), 4696-4708
11Heung-Bae Jeon, Younghee Lee,Chunhua Qiao, He Huang, and Lawrence M. Sayre,“Inhibition of Bovine Plasma Amine Oxidase by 1,4-diamino-2-butenes and-2-butynes”Bioorg. Med. Chem.,2003,11, 4631-4641
研究基金项目
2009-2010：Rhodanine（罗丹宁）衍生物作为新型抗肿瘤药物的研究负责人
课题编号：2009ZX09103-129，创新药物重大专项侯选药物资助，130万。
2011-2013：泛酸合成酶抑制剂作为抗结核药物的研究。课题来源：国家自然科学基金委。课题编号：81072514。32万。
2011-1012：水产用环丙沙星免疫试剂盒的研制。课题来源:苏州市科技局。课题编号：SYN201005； 资助额度：10万。
获奖记录
1998中科院北京化学所优秀青年科技工作者
2004美国PPG奖优秀博士毕业生，2004 PPG Merit Award, Outstanding Graduate Performance
2008苏州市引进紧缺高层次人才
2009苏州大学2009陈金荣生命科学英才奖科研成果二等奖
2011江苏省第四期“333高层次人才培养工程”