何亚文

上海交通大学教授
何亚文，男，2006年毕业于新加坡国立大学生物系，上海交通大学生命科学与技术学院教授，博士生导师。
个人履历
1992年于华中师范大学获生物学学士学位，1995年于中国科学院华南植物研究所获植物生理学硕士学位；1995-1997年在中国科学院华南植物研究所工作，任助理研究员；1997年9月赴新加坡国立大学(National University of Singapore, NUS) 留学，1999年9月获植物学硕士学位；1999年12月加入新加坡分子农业生物学院 (Institute of Molecular Agrobiology)， 任Assistant Research Officer； 2002年加入新加坡分子与细胞生物研究院 (Institute of Molecular and Cell Biology, IMCB)，任Junior Research Fellow，2006年获NUS-IMCB联合培养理学博士学位（研究型）；2007年继续在分子与细胞生物研究院任Research Fellow，从事黄单胞菌群体感应和低氧感应分子机理研究。2010年6月加入上海交通大学生命科学与技术学院，建立微生物群体感应与合成生物学研究室，成为微生物代谢国家重点实验室和代谢与发育科学国际联合实验室独立PI。
研究方向
1. 植物病原微生物群体感应分子机制及基因表达调控网络；
2. 黄单胞菌-植物相互作用攻防战的分子机制
3. 微生物源绿色农药研制与新型生物防治技术。
发表论文
Chen B, LiRF, Zhou L, Qiu JH, Song K, Tang JL,He Ya-Wen.The phytopathogenXanthomonas campestrisutilizes the divergentlytranscribed pobA/pobR locus for 4-hydroxybenzoic acid recognition anddegradation  to promote virulence.Molecular Microbiology,2020 Nov;114(5):870-886.
Jin ZJ, ZhouL, Sun S, Cui Y, Song K, Zhang X,He Ya-Wen.Identification of a Strong Quorum Sensing- and Thermo-Regulated Promoter forthe Biosynthesis of a New Metabolite Pesticide Phenazine-1-carboxamide inPseudomonas strainPA1201.ACS Synthetic Biology.2020 Jul 17;9(7):1802-1812.
He Ya-Wen, Cao XQ, Poplawsky AR Dr. Chemicalstructure, biological roles, biosynthesis and regulation of the yellowxanthomonadin pigments in the phytopathogenXanthomonas.MolecularPlant Microbe Interactions. 2020, 33(5):705-714.
Sun S, Tan LT, Fang YL, Jin ZJ, ZhouL, Goh BH, Lee LH, Zhou J,He Ya-Wen.Overexpression of oxyR Increases Phenazine-1-Carboxylic Acid Biosynthesis viaSmall RNA phrS in the Rhizobacterium StrainPseudomonasPA1201.MolecularPlant Microbe Interactions.2020 Mar;33(3):488-498.
Cao XQ, Ouyang XY, Chen B, Song K,Zhou L, Jiang BL, Tang JL, Ji G, Poplawsky AR,He Ya-Wen. Genetic Interference Analysis Reveals that Both3-Hydroxybenzoic Acid and 4-Hydroxybenzoic Acid Are Involved in XanthomonadinBiosynthesis in the PhytopathogenXanthomonascampestrispv.campestris.Phytopathology.2020 Feb;110(2):278-286.
Keswani C, Singh HB, García-Estrada C,Caradus J,He Ya-Wen,Mezaache-Aichour S, Glare TR, Borriss R, Sansinenea E. Antimicrobial secondarymetabolites from agriculturally important bacteria as next-generationpesticides.Applied Microbiology and Biotechnology.2020Feb;104(3):1013-1034.
Yang Q, Song L, Miao Z, Su M, Liang W,He Ya-Wen. Acetylation of BcHptLysine 161 RegulatesBotrytis cinereaSensitivity to Fungicides, Multistress Adaptation and Virulence.FrontMicrobiol.2020 Jan 8;10: 2965.
Thawai C, Bunbamrung N,Pittayakhajonwut P, Chongruchiroj S, Pratuangdejkul J,He Ya-Wen,Tadtong S, Sareedenchai V, Prombutara P, Qian Y. A novel diterpene agentisolated fromMicrobispora hainanensisstrain CSR-4 and itsin vitroandin silicoinhibition effects on acetylcholine esterase enzyme.SciRep. 2020 Jul 6;10(1):11058.
Law JW, Chan KG,He Ya-Wen, Khan TM, Ab Mutalib NS, Goh BH, Lee LH. Diversity ofStreptomyces spp. from mangrove forest of Sarawak (Malaysia) and screening oftheir antioxidant and cytotoxic activities.Sci Rep.2019 Dec3;9(1):15262.
Chee PY, Mang M, Lau ES, Tan LT,He Ya-Wen, Lee WL, Pusparajah P, ChanKG, Lee LH, Goh BH. Epinecidin-1, an Antimicrobial Peptide Derived From Grouper(Epinephelus coioides): Pharmacological Activities and Applications.FrontMicrobiol.2019 Nov 20;10:2631.
Keswani C, Singh HB, Hermosa R,García-Estrada C, Caradus J,He Ya-Wen,Mezaache-Aichour S, Glare TR, Borriss R, Vinale F, Sansinenea E. Antimicrobialsecondary metabolites from agriculturally important fungi as next biocontrolagents.Appl Microbiol Biotechnol.2019 Dec;103(23-24):9287-9303.
Zhou L, Li M, Wang XY, Liu H, Sun S,Chen H, Poplawsky A,He Ya-Wen.Biosynthesis of Coenzyme Q in the PhytopathogenXanthomonas campestrisvia a Yeast-Like Pathway.MolPlant Microbe Interact. 2019，32(2):217-226.
Diab AA, Cao XQ, Chen H, Song K, ZhouL, Chen B,He Ya-Wen. BDSF Isthe Predominant In-Planta Quorum-Sensing Signal Used DuringXanthomonas campestrisInfection andPathogenesis in Chinese Cabbage.Mol Plant Microbe Interact. 2019, 32(2):240-254.
Thawai C,He Ya-Wen, Tadtong S.Jishengellazingiberissp. nov., isolated from root tissue ofZingiber montanum.Int J Syst Evol Microbiol. 2018 Oct;68(10):3345-3350.
Cao, XQ, Zhou L, Chen B,He Ya-Wen. Biosynthesis ofXanthomonasyellow pigment xanthomonadinsinvolves an ATP-dependent 3- HBA:ACP ligase and an unusual type II polyketidesynthesis pathway.Molecular Microbiology.2018, Oct; 110(1):16-32.
Qi X, Qu H, Yang D, Zhou L,He Ya-Wen, Yu Y, Qu J, Liu J. Lowerrespiratory tract microbial composition was diversified inPseudomonas aeruginosaventilator-associated pneumonia patients.RespirRes.2018 Jul 27;19(1):139.
Fang Y L, Chen B, Zhou L,He Ya-Wen. The mechanismunderlying the regulatory roles of anti-activator QslA on the biosynthesis of phenazine-1-carboxylicacid inPseudomonas aeruginosaPA1201.Frontiers in Microbiology. 2018, Jul 25; 9:1584.
Zhou L, Sun S, Zhang W,He Ya-Wen. Ultra-PerformanceLiquid Chromatography/Mass Spectrometry for the Detection and Quantification ofDiffusible Signal Factor (DSF) Family Quorum-Sensing Signals.MethodsMol Biol.2018, 1673:97-105.
Sun S, Chen B, Jin ZJ, Zhou L,Fang YL, Thawai C, Rampioni G,He Ya-Wen.Characterization of the multiple molecular mechanisms underlying RsaL controlof phenazine-1-carboxylic acid biosynthesis in the rhizosphere bacteriumPseudomonas aeruginosaPA1201.MolecularMicrobiology. 2017, 104(6):931-947.
Zhou L, Wang X, Zhang W, Sun S,He Ya-Wen. Extraction, Purification andQuantification of Diffusible Signal Factor Family Quorum Sensing SignalMolecules inXanthomonas.Bio-protocol,2017, 7(6): e2190.
Zhou L, Zhang LH, Cámara M,He Ya-Wen. The DSF Family of QuorumSensing Signals: Diversity, Biosynthesis, and Turnover inXanthomonas.Trends in Microbiology. 2017,25(4):293-303.
Sun S, Zhou L, Jin K, Jiang H,He Ya-Wen. Quorum sensing systemsdifferentially regulate the production of phenazine-1-carboxylic acid in therhizobacteriumPseudomonas aeruginosaPA1201.ScientificReports, 2016, 6:30352.
Wang Xing-Yu, Zhou Lian, Yang J,Ji Guang-Hai,He Ya-Wen. TheRpfB-Dependent Quorum Sensing Signal Turnover System Is Required for Adaptationand Virulence in the PathogenXanthomonas.MolecularPlant-Microbe Interactions. 2016, 29(3):220-30.
Zhou Lian, Jiang Haixia, SunShuang, Yang Dandan, Jin Kaiming,HeYa-Wen. Biotechnological potential of a rhizospherePseudomonas aeruginosastrain producingphenazine-1-carboxylic acid and phenazine-1-carboxamide.World Journal of Microbiology andBiotechnology, 2016, 32(3):50.
Zhou Lian*, Wang Xing-Yu*, SunShuang, Yang Li-Chao, Jiang Bo-Le,HeYa-Wen.Identification and Characterization of Naturally OccurringDSF-Family Quorum Sensing Signal Turnover System in the PhytopathogenXanthomonas.Environmental Microbiology,2015, 17(11):4646–4658.
Jin Kaiming*, Zhou Lian*, JiangHaixia, Sun Shuang, Fang Yunling, Liu Jianhua, Zhang Xuehong,He Ya-Wen. Engineering thecentral biosynthetic and secondary metabolic pathways ofPseudomonas aeruginosastrain PA1201 to improvephenazine-1-carboxylic acid production.Metabolic Engineering, 2015,32:30-38.
Wang Jia-Yuan*, Zhou Lian*, ChenBo, Sun Shuang, Zhang Wei, Li Ming, Tang H, Jiang Bo-Le, Tang Ji-Liang,He Ya-Wen. A functional4-hydroxybenzoate degradation pathway in the phytopathogenXanthomonas campestrisis required for full pathogenicity.ScientificReports, 2015, 5: 18456.
Zhou Lian, Yu Yonghong, ChenXiping, Diab AA, Ruan Lifang, He Jin, Wang Haihong,HeYa-Wen. The Multiple DSF-family QS Signals are synthesizedfrom Carbohydrate and Branched-chain Amino Acids via the FAS Elongation Cycle.ScientificReports, 2015, 5:13294.
Xu Shu, Pan X, Luo J, Wu J, ZhouZ, Liang X,He Ya-Wen,ZhouMingguo. Effects of phenazine-1-carboxylic acid on the biology of theplant-pathogenic bacteriumXanthomonasoryzaepv.oryzae.PesticideBiochemistry and Physiology, 2015, 117:39-46.
Xu Jing, Zhou Lian, Venturi V,He Ya-Wen, Kojima M, Sakakibari H,Höfte M, De Vleesschauwer D. Phytohormone-mediated interkingdom signalingshapes the outcome of rice-Xanthomonasoryzaepv.oryzaeinteractions.BMCPlant Biology,2015,15: 10.
Zhou Lian*, Wang Jia-Yuan*, WangJianhe, Poplawsky A, Lin Shuangjun, Zhu Bangshang, Chang Changqing, ZhouTieling, Zhang Lian-Hui,HeYa-Wen.Thediffusible factor (DF) synthase XanB2 is a bifunctional chorismatase that linksthe shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways.MolecularMicrobiology,2013, 87(1): 80-93.
Zhou Lian, Huang Tin-Wei, SunShuang, Wang Jia-Yuan, Chen Gongyou, Poplawsky AR,He Ya-Wen.  The rice acterialpathogenXanthomonas oryzaepv.oryzaeproduces 3-hydroxybenzoic acidand 4-hydroxybenzoic acid via XanB2 for use in xanthomonadin, ubiquinone andexopolysaccharide biosynthesis.Molecular Plant-Microbe Interactions.2013, 26(10):1239-48.
Qian Guoliang, Wang Y, Liu Y, XuF,He Ya-Wen, Du Liangcheng, VenturiV, Fan Jiaqing, Hu Boshi, Liu Fengquan.Lysobacterenzymogenesuses two distinct cell-cell signaling systems for differentialregulation of secondary metabolite biosynthesis and colony morphology.Appliedand Environmental Microbiology.2013, 79(21): 6604-6616.
Wu Da-Qiang, Ye Jing, Ou Hong-Yu,Wei Xue, Huang Xianqing,He Ya-Wenand Xu Yuquan. Genomic analysis and temperature-dependenttranscriptome profiles of the rhizosphere originating strainPseudomonas aeruginosaM18.BMCGenomics，2011, 12：438.
Zhou L, Vorholter FJ, He YQ, Jiang BL, Tang JL, Xu Y, Puhler A, He YW* (2011) Gene discovery by genome-wide CDS re-prediction and microarray-based transcriptional analysis in phytopathogen Xanthomonas campestris. BMC Genomics,12(1):359（* corresponding authors).
He YW*, Wu J, Zhou L, Yang F, Jiang BL, Tang JL, Bai L, Xu Y, Deng Z, Zhang LH* (2011) Xanthomonas campestris diffusible factor is 3-hydroxybenzoic acid and associated with xanthomonadin biosynthesis, cell viability, antioxidant activity and systemic invasion. Mol Plant Microbe Interact. 24(8):948-57（*corresponding authors).
He YW*, Wu JE, Cha JS, Zhang LH* (2010) Rice bacterial blight pathogen Xanthomonas oryzae pv. oryzae produces multiple DSF-family signals in regulation of virulence factor production. BMC Microbiology,10:187 (* corresponding authors).
Cheng Z&, He YW&, Lim SC&, Qamra R&, Walsh MA, Zhang LH, Song H (2010) Structural Basis of the Sensor-Synthase Interaction in Autoinduction of the Quorum Sensing Signal DSF Biosynthesis. Structure,18(9):1199-1209 (& equal contributors).
Tao F, He YW, Wu DH, Swarup S, Zhang LH (2010) The cyclic nucleotide monophosphate domain of Xanthomonas campestris global regulator Clp defines a new class of cyclic di-GMP effectors. The Journal of Bacteriology, 192(4):1020-9.
HE YW, Boon C, Zhou L, Zhang LH (2009) Co-regulation of Xanthomonas campestris virulence by quorum sensing and a novel two-component regulatory system RavS/RavR. Molecular Microbiology, 71(6):1464-1476.
He YW, Zhang LH (2008) Quorum Sensing and Virulence Regulation in Xanthomonas campestris. FEMS Microbiology Reviews, 32: 842-857.
Boon C, Deng Y, Wang LH, He YW, Xu JL, Fan Y, Pan SQ, Zhang LH (2008) A novel DSF-like signal from Burkholderia cenocepacia interferes with Candida albicans morphological transition. International Society of Microbial Ecology Journal (ISMEJ), 2(1):27-36.
He YW, Ng YJ, Xu M, Lin K and Zhang LH (2007) Xanthomonas campestris cell-cell communication involves a nucleotide receptor protein Clp and a hierarchical signaling network. Molecular Microbiology, 64(2):281-292.
He YW, Wang C, Zhou L, Song H, Dow JM, Zhang LH (2006) Dual signaling functions of the hybrid sensor kinase RpfC of Xanthomonas campestris involve either phosphorelay or receiver domain-protein interaction. The Journal of Biological Chemistry, 281:33414 – 33421.
Ryan RP, Fouhy Y, Lucey JF, Crossman LC, Spiro S, He YW, Zhang LH, Heeb S, Camara M, Williams P, Dow JM (2006) Cell-cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover. Proceedings of National Academy of Science of USA, 103(17):6712-6717.
He YW, Xu M, Lin K, Ng YJ, Wen CM, Wang LH, Liu ZD, Zhang HB, Dong YH, Dow JM and Zhang LH (2006) Genome scale analysis of diffusible signal factor regulon in Xanthomonas campestris pv. campestris: identification of novel cell-cell communication-dependent genes and functions. Molecular Microbiology, 59(2):610-622.
Wang LH, He YW, Gao YF, Wu JE, Dong YH, Wang RB, He CZ, Wang SX, Weng LX, Xu JL, Tay L, Fang RX, Zhang LH (2004) A bacterial cell-cell communication signal with cross-kingdom structural analogs. Molecular Microbiology, 51(3):903-12.
Lo J&, Lee S&, Xu M&, Liu F&, Ruan H&, Eun A&, He YW&, Ma W&, Wang W, Wen Z, Peng J (2003) 15,000 unique zebrafish est clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome Research,13:455-466. (&equal contributors).
Lee S, Cheng H, King KE, Wang W, He YW, Hussain A, Lo J, Harberd NP, Peng J (2002) Gibberellin regulates Arabidopsis seed germination via RGL2, a GAI/RGA-like gene whose expression is up-regulated following imbibition. Genes and Development, 16:646-658.
He YW and Loh CS (2002) Induction of early bolting in Arabidopsis thaliana by triacontanol, cerium and lanthanum is correlated with increased endogenous concentration of isopentenyl adenosine (iPAdos). Journal of Experimental Botany, 53 (368):505-512.
He YW and Loh CS (2000) Cerium and lanthanum promote floral initiation and reproductive growth of Arabidopsis thaliana. Plant Science, 159:117-1