徐宏喜

上海中医药大学首席教授
徐宏喜，男，汉族，现为上海中医药大学首席教授、上海中医药大学中药学院名誉院长、国家中组部特聘教授，上海市首批特聘专家，香港中文大学中医学院客座教授；兼任国务院学位委员会中药学学科评议组秘书长、教育部高等学校中药学类专业教指委委员、国家药典委员会委员、中华中医药学会中药实验药理学分会主任委员、上海市药学会中药专业委员会主任委员、国际现代化中医药学术会议联席主席等职。磐龙玉矿物药国际研究院院长、创新药物研发上海高校工程中心主任、上海中医药大学附属曙光医院双聘教授。1994年获得日本富山医科药科大学国立和汉药研究所药学博士学位。并于新加坡国立大学化学系及加拿大Dalhousie大学微生物学系进行博士后研究工作。曾先后受聘于香港中文大学中药研究中心科学主任、香港和记黄埔(中国)有限公司副总经理兼高级医药顾问，上海和黄药业有限公司董事兼研究开发总监。2001至2010年,担任香港赛马会中药研究院副总裁兼中药研究室主任。徐教授已发表SCI论文370多篇，被引数1.7万多次，H-index指数为70，i10-index 指数为273 (Google Scholar)。于2014年连续8年入选中国高被引用学者榜。先后主持40余项国家级及国内外企业合作研发项目。获得16项美国专利授权和38项中国专利授权，PCT专利1项，三项中药抗病毒专利及成果成功转让。培养博士后25人，博士及硕士研究生90余人，主编十三五规划教材《中药药理学》等专著7部。
人物介绍
徐教授的主要社会兼职包括：国家药典会天然药物专业委员会委员、教育部高等学校中药类专业教学指导委员会委员、中华中医药学会中药实验药理学分会主任委员、中国中医药信息研究会中药材及饮片质量分会名誉会长、世界中医药学会联合会中药分析专业委员会副会长、世界中医药学会联合会中药鉴定专业委员会副会长、全国中医药高等教育学会中药教育研究会第三届理事会副理事长、中国整合药学联盟第一届理事会副理事长、国际现代化中医药学术会议联席主席、现代化中医药国际协会创会董事、香港中药药理学会副会长、上海市药学会中药专业委员会主任委员、上海市药理学会中药药理专业委员会主任委员、国际国内十余种学术刊物的编委等职。先后70余次应邀前往美国、日本、新加坡、马来西亚、葡萄牙、法国、英国、南非、比利时、新西兰、澳大利亚、韩国、巴西、加拿大、奥地利、印度等国家以及中国台湾地区、中国香港地区、中国澳门地区等地做特邀学术报告或学术会议交流。
曾任上海中医药大学中药学院院长。
研究方向
主要研究领域包括中药活性成分及药效评价研究，中药保健产品及新药开发研究等。重点进行病毒、肿瘤、耐药菌及炎症等疾病的中药防治与药效评价研究，阐明中药药效物质基础及作用机制，研发具有自主知识产权的创新药物。
抗病毒及抗耐药菌中药药理机制研究
从事中药及其活性成分抗病毒及抗耐药菌药理作用机制研究。已建立抗病毒（HSV和EV71）筛选平台及基于MgrA靶标蛋白荧光探针的高通量筛选体系，致力于阐明中药抗病毒和抗金黄色葡萄球菌耐药菌活性的物质基础，揭示其药效作用机制，发现活性强、毒性小、选择性高的中药活性组分及先导化合物。
抗肿瘤中药药理作用机制研究
从事中药及其活性成分抗肿瘤药理作用机制研究。已建立分子、细胞及动物水平的抗肿瘤药物筛选及药效评价模型，重点开展肝癌、前列腺癌及胰腺癌的体内外药效筛选和药效评价，致力于从中草药和天然产物中寻找抗肿瘤先导化合物，阐明其诱导肿瘤细胞凋亡、调节自噬、抑制转移及防止复发等药效作用机制。近年来重点开展中国产藤黄属植物中具有抗肿瘤活性的PPAPs类和xanthones类成分的鉴定及其作用机制研究。
中药研究论文
1. Y. Y. Li, Y. Lu, S.W.Wang, Z.J.Han, F.X.Zhu, Y. M. Ni, R. Liang, Y. Zhang, Q. B. Leng, G. Wei, G. C. Shi, R. H. Zhu, D. Li, H. K. Wang, S. G. Zheng, H. X. Xu, A.Tsun, B. Li, USP21 prevents the generation of T-helper-1-like Treg cells, Nature Communications, 7: 13559 (2016).
2. M.Wong, YT. Sun, Z.C.Xi, G.Milazzo, R.C. Poulos, C.Bartenhagen, J.L. Bell, C.Mayoh, N.Ho, A. E. Tee, X.Q.Chen, Y.Li, R.Ciaccio, P.Y. Liu, C.C. Jiang, Q.Lan, N.Jayatilleke, B.B. Cheung, M.Haber, M.D. Norris, X.D. Zhang, G.M. Marshall, J. Y. Wang, S.Hüttelmaier, M.Fischer, J.W. H. Wong, H.X.Xu, G.Perini, Q.H.Dong, R.E. George, T.Liu, JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma, Nature Communications, 10(1):3319. (2019).
3. Y. Z. Lao, G. Wan, Z. Y. Liu, X. Y. Wang, P. Ruan, W. Xu, D. Q. Xu, W. D. Xie, Y. Zhang,H. X. Xu, N. H. Xu, The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation, Autophagy, 10(5): 1-14 (2014).
4. G. Wan, W. D. Xie, Z. Y. Liu, W. Xu, Y. Z. Lao, N. Huang, K. Cui, M. J. Liao, J. He, Y. Y. Jiang, Burton B Yang, H. X. Xu, N. H. Xu, Y. Zhang, Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway, Autophagy, 10(1): 70-79 (2014).
5. M.H.Feng, B.Q.Tang, N.Z.Wang,H. X. Xu, X.F.Jiang, Ligand Controlled Regiodivergent C1 Insertion on Arynes for Construction of Phenanthridinone and Acridone Alkaloids., Angewandte Chemie (International ed. in English), 54(49), 14960-4 (2015).
6. G. Lin, J. Y. Wang, N. Li, M. Li, H. Gao, Y. Ji, F. Zhang, H. L. Wang, Y. Zhou, Y. Ye, H. X. Xu, J. Zheng, Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum, Journal of Hepatology, 54(4):666-73 (2011).
7. H. L. Zhao, Y. Sui, C. F. Qiao, K. Y. Yip, R. K. K. Leung, S. K. W. Tsui, H. M. Lee, H. K. T. Wong, X. Zhu, J. J. Siu, L. He, J. Guan, L. Z. Liu,H. X. Xu, P. C. Y. Tong, J. C. N. Chan, Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression, Diabetes, 61(4), 933-943 (2012).
8. L.Bi, C.L.Xie, M.Yao, S.S.T.Hnit, S.Vignarajan, Y.Wang, Q.Wang, Z.C.Xi, H.X. Xu, Z.Li, P.D.Souza, A.Tee, M.Wong, T.Liu, X.D.Zhao, J.Zhou, L.Xu, Q.H.Dong, The histone chaperone complex FACT promotes proliferative switch of G0 cancer cells, International Journal of Cancer, 145(1):164-178. (2018)
9. Y. Lu, N.M.Kim, Y.W.Jiang, H.Zhang, D. Zheng, F.X. Zhu, R. Liang, B. Li, H.X.Xu, Cambogin suppresses dextran sulphate sodium‐induced colitis by enhancing Treg cell stability and function. British Journal of Pharmacology, 175: 1085–1099 (2018)
10. Y. Liao, X. Liu, J. Yang, Y.Z. Lao, X.W.Yang, X.N.Li, J.J.Zhang, Z.J.Ding,H. X. Xuand G. Xu, Hypersubones A and B, New Polycyclic Acylphloroglucinols with Intriguing Adamantane Type Cores from Hypericum subsessile, Organic Letters, 17 (5), 1172–1175(2015).
11. Y.Qiu, Y.M.Sun, D.Q.Xu, Y.Y.Yang, X.J.Liu, Y.Wei, Y.H.Chen, Z.H.Feng, S.Li, Md.R.Ferdous, Y.X.Zhao, H.X.Xu, Y.Z.Lao, Q.R.Ding，Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue，EBioMedicine, 37:344-355. (2018)
12. M. H. Feng, B .Q. Tang, H. X. Xu, X. F. Jiang, Collective Synthesis of Phenanthridinone through C-H Activation Involving a Pd-Catalyzed Aryne Multicomponent Reaction, Organic Letters, 18(17):4352-5(2016).
13. L.Wang, L.Sun, X.Y.Wang, R.Wu, H.Zhou, C.W.Zheng, H.X.Xu, Me2AlSEt-Promoted Domino Dieckmann Cyclization Enables the Total Synthesis of Polycyclic Polyprenylated, Organic Letters, 21,19,8075-8079 (2019)
14. Y.L.Wang, Y.S.Ye, W.W.Fu, R.Wu, Q.Xiang, Y.Z.Lao, J.L.Yang, H.S.Tan, X.W.Yang, B.C.Yang, H.X.Xu, G.Xu, Garsubelone A, the First Dimeric Polycyclic Polyprenylated Acylphloroglucinols with Complicated Heptacyclic Architecture from Garcinia subelliptica, Organic Letters,21(5):1534-1537. (2019)
15. X. W. Yang, X. Deng,X. Liu, C. Y. Wu,X. N. Li,B. Wu, H. R. Luo, Y. Li,H. X. Xu, Q. S. Zhao, G. Xu, Hypercohin A, a new polycyclic polyprenylated acylphloroglucinol possessing an unusual
bicyclo[5.3.1]hendecane core from Hypericum cohaerens, Chemical Communications, 48: 5998-6000 (2012).
16. L.Zhang, J.L.Feng, S.Y.Kong, M.Wu, Z.C.Xia, B.J.Zhang, W.W.Fu, Y.Z.Lao, H.S.Tan, H. X. Xu. Nujiangexathone A, a novel compound from Garcinia nujiangensis, suppresses cervical cancer growth by targeting hnRNPK, Cancer letters, 380(2):447-456 (2016).
17. C. Feng, L. Y. Zhou, T. Yu, G. Xu, H. L. Tian, J. J. Xu,H. X. Xu, K. Q. Luo, A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation, International Journal of Cancer, 131(6): 1445-1454 (2012).
18. Z.C.Xi, M.Yao, Y.Li, C.L.Xie, J. Holst, T. Liu, S.F.Cai, Y.Z.Lao, H.S.Tan,H. X. Xuand Q.H. Dong,Guttiferone Kimpedes cell cycle re-entry of quiescent prostate cancer cellsvia stabilization of FBXW7 and subsequent c-MYC degradation, Cell Death & Disease, 7(6):e2252(2016).
19. L.F.Xu, X.X.Meng, N.H.Xu, W.W.Fu, H.S.Tan, L.Zhang, Q.J.Zhou, J.N.Qian, S.W.Tu, X.T. Li, Y.Z. Lao, H.X.Xu, Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth, Cell Death & Disease, 9 (3) : 262 (2018)
20. Y.Li, Z.C.Xi, X.Q. Chen, S.F. Cai, C. Liang, Z. Wang, Y.Y. Li, H.S. Tan, Y.Z. Lao, H.X.Xu, Natural compound Oblongifolin C confers gemcitabine resistance in pancreatic cancer by downregulating Src/MAPK/ERK pathways, Cell Death Disease, 9(5):538 (2018)
21. J.Zhang, Z.Q.Zheng, M.Wu, L.Zhang, J.Wang, W.W.Fu, N.H.Xu, Z.L.Zhao, Y.Z.Lao, H.X.Xu, The natural compound neobractatin inhibits tumor metastasis by upregulating the RNA-binding-protein MBNL2. Cell Death & Disease, 10(8):554 (2019).
22. D.Zheng, H.Zhang, C.W.Zheng, Y.Z.Lao, D.Q.Xu, L.B.Xiao, H.X.Xu, Garciyunnanimines A–C, novel cytotoxic polycyclic polyprenylated acylphloroglucinol imines from Garcinia yunnanensis, Organic Chemistry Frontiers, 4, 2102–2108(2017).
23. K.K. Shen, J.L.Xie, H. Wang, H.Zhang, M.Y.Yu, F.F. Lu, H.S. Tan, H. X. Xu, Cambogin induces caspase-independent apoptosis through the ROS/JNK pathway and epigenetic regulation in breast cancer cells, Molecular Cancer Therapeutics, 14(7):1738-1749. (2015).
24. H.Zhang, J.M.Jiang, L.Han, Y.Z.Lao, D.Zheng, Y.Y.Chen, S.J.Wan, C.W.Zheng, H.S.Tan, Z.G.Li, H.X.Xu, Uncariitannin, a polyphenolic polymer from Uncaria gambier, attenuates Staphylococcus aureus virulence through an MgrA-mediated regulation of α-hemolysin. Pharmacological Research, 147:104328. (2019)
25. X. H. Pang, J. Y. Song, Y. J. Zhu, H. X. Xu, L. F. Huang, S. L. Chen, Applying plant DNA barcodes for Rosaceae species identification, Cladistics, 27(2), 165-170 (2011).
26. X.Y. Wang, Y. Z. Lao, N.H. Xu, Z.C. Xu, M. Wu, H. Wang, X. Li, H.S. Tan, M.H. Sun, H. X. Xu, Oblongifolin C inhibits metastesis by up-regulating keratin 18 and tubulins, Scientific Reports, 5:10293-10305. (2015).
27. Y.Lu, S.F.Cai, J.Nie, Y.Y. Li, G.C.Shi, J.M.Hao, W.W.Fu, H.S.Tan, S.L.Chen, B. Li,H. X. Xu,The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma, Biochemical Pharmacology, 100:61-72(2015).
28. W. L. Ting Kan, C. Yin,H. X. Xu, G. Xu, K. K. W. To, C. H. Cho, J. A. Rudd, G. Lin, Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G0/G1 cell cycle arrest and apoptosis, International Journal of Cancer, 132(3): 707-716 (2013).
29. N.Kim, P.Lertnimitphun, Y.W.Jiang, H.S.Tan, H.Zhou, Y.Lu, H. X. Xu, Andrographolide inhibits inflammatory responses in LPS-stimulated macrophages and murine acute colitis through activating AMPK. Biochemical pharmacology, 170:113646. (2019)
30. Q. B. Han, S. Cheung, J.Tai, C. F. Qiao, J. Z. Song, T. F. Tso, H. D. Sun, H. X. Xu, Maoecrystal Z, a Cytotoxic Diterpene from Isodon eriocalyx with an Unique Skeleton, Organic Letters, 8 (21), 4727-4730 (2006).
31. T. W. D. Chan, P. P. H. But, S. W. Cheng, I. M. Y. Kwok, F. W. Lau, H. X. Xu, Differentiation and authentication of Panax ginseng, Panax quinquefolius and ginseng products by using HPLC/MS, Analytical Chemistry, 72(6), 1281-1287 (2000).
32. H.Zhang, D.Zheng, Z.J.Ding, Y.Z.Lao, H.S.Tan, H.X.Xu, UPLC-PDA-QTOFMS-guided isolation of prenylated xanthones and benzoylphloroglucinols from the leaves of Garcinia oblongifolia and their migration-inhibitory activity，Scientific Reports, 6: 35789 (2016).