徐凌燕

华东师范大学生命科学学院研究员
徐凌燕，华东师范大学生命科学学院研究员、博士生导师，带领应激与代谢稳态课题组，致力于研究代谢器官响应营养和衰老应激，参与代谢稳态调控的关键分子和作用机制。
个人经历
2001-2005复旦大学生命科学学院    生物化学与分子生物学专业     理学学士
2005-2010    中国科学院上海生命科学研究院健康科学研究所
生物化学与分子生物学/内分泌代谢病专业    硕博连读    理学博士
导师：宁光(中国工程院院士)
2010-2011    中国科学院上海生命科学研究院   内分泌与代谢病实验室    助理研究员
2011-2016美国国立卫生研究院National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)   博士后
导师：Elisabetta Mueller (师从哈佛大学医学院美国国家科学院院士Bruce Spiegelman)
2017-           华东师范大学生命科学学院      生命医学研究所      研究员
所获荣誉
入选“上海市浦江人才计划（A类）”
入选华东师范大学青年高层次人才“紫江学者”项目 “紫江青年学者”
科学研究
研究领域
随着现代社会生活方式的改变，过度的营养摄入、运动缺乏以及老龄化引起的能量代谢异常和线粒体损伤，在中老年人群中导致“中年发福”现象高发，推动肥胖，糖尿病和脂肪肝等代谢性疾病在世界范围内快速增长，严重危害人类健康。脂肪和肝脏是响应营养和衰老应激，调控机体糖脂代谢变化的重要器官，然而具体的调控分子和机制尚不清晰。因此阐明脂肪和肝脏中关键分子的应激响应机制，以及代谢稳态的调控网络，对于防治代谢性疾病具有重要意义。本课题组长期研究脂肪和肝脏响应营养和衰老应激，参与代谢稳态调控的关键分子和作用机制：(1) 鉴定并系统解析营养过剩引起的合成增加、分解降低，以及在肥胖和脂肪肝发生发展中的影响和调控机制；(2) 创新性发现衰老应激中细胞糖脂代谢和能量平衡紊乱的发生机制和内源性调控。
科研成果
近年来发表SCI论文32篇；其中以第一和通讯作者（含共同）身份在Cell Metabolism, PNAS(两篇), Journal of Hepatology, Hepatology, Aging Cell(两篇)等国际著名学术期刊发表文章27篇，影响因子合计约180，引用500余次。2017年于华东师范大学生命科学学院建立实验室以来，在Journal of Hepatology, Hepatology, Oncogene, Molecular Metabolism (Cover Story) 等国际著名学术期刊发表SCI论文15篇，其中以通讯作者（含共同）身份发表论文9篇。工作受到Nat Med, Nat Rev Endocrinol, Cell Metab, Mol Cell等杂志引用和评论，F1000 “Exceptional”推荐，新闻媒体等亮点报道。入选上海市 “浦江人才计划”和华东师范大学青年高层次人才计划“紫江青年学者”等人才项目。
部分发表论文
1. Liu C*, Zhou B*, Meng M*, Zhao W, Wang D, Yuan Y, Zheng Y, Qiu J, Li Y, Li G, Xiong X, Bian H, Zhang H, Wang H, Ma X#, Hu C#,Xu L#, Lu Y#.FOXA3 induction under endoplasmic reticulum stress contributes to non-alcoholic fatty liver disease.J Hepatol2021, S0168-8278(21)00090-8.
2. Qiu J*, Zhang Z*, Wang S*, Chen Y*, Liu C, Xu S, Wang D, Su J, Ni M, Yu J, Cui X, Ma L, Hu T, Hu Y, Gu X#, Ma X#, Wang J#,Xu L#. Transferrin Receptor Functionally Marks Thermogenic Adipocytes.Front Cell Dev Biol. 2020, 8:572459.
3.Xu L*, Ma X*, Verma N, Perie L, Pendse J, Shamloo S, Marie Josephson A, Wang D, Qiu J, Guo M, Ping X, Allen M, Noguchi A, Springer D, Shen F, Liu C, Zhang S, Li L, Li J, Xiao J, Lu J, Du Z, Luo J, Aleman JO, Leucht P, Mueller E. PPARγ agonists delay age-associated metabolic disease and extend longevity.Aging Cell. 2020 Nov;19(11):e13267.
5. Guo M*, Qiu J*, Shen F*, Wang S, Yu J, Zuo H, Yao J, Xu S, Hu T, Wang D, Zhao Y, Hu Y, Shen F, Ma X#, Lu J#, Gu X#,Xu L#. Comprehensive analysis of circular RNA profiles in skeletal muscles of aging mice and after aerobic exercise intervention.Aging (Albany NY).2020 Mar 17;12. doi: 10.18632/aging.102932.
6. Zhou B*, Liu C*,Xu L*, Yuan Y, Zhao J, Zhao W, Chen Y, Qiu J, Meng M, Zheng Y, Wang D, Gao X, Li X, Zhao Q, Wei X, Wu D, Zhang H, Hu C, Zhuo X, Zheng M, Wang H#, Lu Y#, Ma X#. N6-methyladenosine Reader Protein Ythdc2 Suppresses Liver Steatosis via Regulation of mRNA Stability of Lipogenic Genes.Hepatology.2020 Mar 9. doi: 10.1002/hep.31220.
8. Cheng X*, Qiu J*, Wang S, Yang Y, Guo M, Wang D, Luo Q,Xu L#. Comprehensive circular RNA profiling identifies CircFAM120A as a new biomarker of hypoxic lung adenocarcinoma.Ann Transl Med.2019;7(18):442.
9. Wang D*, Cheng X*, Li Y, Guo M, Zhao W, Qiu J, Zheng Y, Meng M, Ping X, Chen X, Wang S, Luo J, Luo Q, Ma X#,Xu L#. C/EBPδ-Slug-Lox1 axis promotes metastasis of lung adenocarcinoma via oxLDL uptake.Oncogene. 2020 Jan;39(4):833-848. doi: 10.1038/s41388-019-1015-z.
10. Ma X, Feng D, Lu Y, Sun N, Wang J,Xu L. Editorial: Novel Strategies Targeting Obesity and Metabolic Diseases.Front Physiol.2019 May 29;10:668. doi: 10.3389/fphys.2019.00668.
11. Yue L*，Zhao W*, Wang D*, Meng M, Zheng Y, Li Y, Qiu J, Yu J, Yan Y, Lu P, Sun Y, Fu J, Wang J, Zhang Q,Xu L#, Ma X#, Silver nanoparticles inhibit beige fat function and promote adiposity.Mol Metab.2019 Apr;22:1-11. doi: 10.1016/j.molmet.2019.01.005.
12. Ma X, Wang D, Zhao W,Xu L. Deciphering the Roles of PPARγ in Adipocytes via Dynamic Change of Transcription Complex.Front. Endocrinol2018; 9:473.
13.Xu L, Zhao W, Wang D, Ma X. Chinese Medicine in the Battle against Obesity and Metabolic Diseases.Front Physiol2018; 9:850.
14.Xu L*, Ma X*, Verma NK, Wang D, Gavrilova O, Proia RL, Finkel T, Mueller E. Ablation of PPARγ in subcutaneous fat exacerbates age-associated obesity and metabolic decline.Aging Cell2018; 17.
15. Alexaki A, Clarke BA, Gavrilova O, Ma Y, Zhu H, Ma X,Xu L, Tuymetova G, Larman BC, Allende ML, Dunn TM, Proia RL. De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis.J Biol Chem2017; 292:3929-3939.
16.Ma X*,Xu L*, Muller E. Forkhead box A3 Mediates Glucocorticoid Receptor Function in Adipose Tissue.Proc Natl Acad Sci USA2016; 113:3377-3382.
17.Xu L*, Ma X*, Bagattin A, Mueller E. The transcriptional coactivator PGC1α protects against hyperthermic stress via cooperation with the heat shock factor HSF1.Cell Death & Disease2016; 7:e2102.
18. Ma X,Xu L, Mueller E. Calorie hoarding and thrifting: Foxa3 finds a way.Adipocyte2015; 4:325-328.
19. Ma X*,Xu L*, Alberobello AT, Gavrilova O, Bagattin A, Skarulis M, Liu J, Finkel T, Mueller E. Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis.
Cell Metab.2015; 22:695-708.
20. Ma X*,Xu L*, Gavrilova O, Mueller E. Role of forkhead box protein A3  in age-associated metabolic decline.Proc Natl Acad Sci USA2014; 111:14289-14294.
21.Xu L*, Panel V*, Ma X*, Du C, Hugendubler L, Gavrilova O, Liu A, McLaughlin T, Kaestner KH, Mueller E. The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion.Mol Cell Biol2013; 33:3392-3399.
22. Qi Y, Li X, Ma X,Xu L, Zhang X, Jiang X, Hong J, Cui B, Ning G, Wang S. The role of osteopontin in the induction of the CD40 ligand in Graves' disease.Clin Endocrinol (Oxf)2014; 80:128-134.
23. Li X*, Qi Y*, Ma X*, Huang F, Guo H, Jiang X, Hong J, Lin D, Cui B, Ning G#,Xu L#, Wang S#. Chemokine (C-C motif) ligand 20, a potential biomarker for Graves' disease, is regulated by osteopontin.PLoS One2013; 8:e64277.
24. Liu R*, Ma X*,Xu L*, Wang D, Jiang X, Zhu W, Cui B, Ning G, Lin D, Wang S. Differential MicroRNA Expression in Peripheral Blood Mononuclear Cells from Graves' Disease Patients.J Clin Endocrinol Metab2012; 97:E968-E972.
25.Xu L*, Ma X*, Wang Y*, Li X, Qi Y, Cui B, Li X, Ning G, Wang S. The expression and pathophysiological role of osteopontin in Graves' disease.J Clin Endocrinol Metab2011; 96:E1866-E1870.
26. Ma X*,Xu L*, Wang S, Cui B, Li X, Xu J, Ning G. Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis.J Hepatol2011; 55:445-452.
27.Xu L*, Ma X*, Cui B, Li X, Ning G, Wang S. Selection of reference genes for qRT-PCR in high fat diet-induced hepatic steatosis mice model.Mol Biotechnol2011; 48:255-262.
28.Xu L*, Ma X*, Li JL, Li X, Xu J, Ning G, Wang S. SRC-3 deficient mice developed fat redistribution under high fat diet.Endocrine2010; 38:60-66.
30. Ma X*,Xu L*, Wang S, Chen H, Xu J, Li X, Ning G. Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis.Lab Invest2009; 89: 903-914.