赖德华

中山大学生命科学学院副教授
赖德华，男，博士，中山大学生命科学学院副教授、硕士生导师。
研究方向
分子寄生虫学及进化
寄生虫是一类特殊的动物，需要寄生在一个或多个宿主体内。我们不仅研究寄生虫的形态、生活史、感染力、抗药性等基本寄生虫学特征，还研究基因及蛋白功能与进化。
个人经历
2013 – 至今	副教授 硕士生导师	中山大学
2014 – 至今	广东省动物学会理事	广东省动物学会
2017 – 至今	原生动物学分会理事	中国动物学会
2018 – 至今	广东省寄生虫学会理事	广东省寄生虫学会
2010 – 2012	居里夫人访问学者	英国牛津大学
2011 – 2012	英国STEM大使	Researchers in Residence
2008 – 2010	博士后	捷克南波希米亚大学
2003 – 2008	博士	中山大学
1999 – 2003	学士	中山大学
讲授课程
滨海动物学实习（本科大一暑假）
生物化学（本科大二）
学术规范与论文写作（研究生第一年第二学期）
学术成就
一直从事人兽共患寄生虫的研究，并取得显著成绩，2005年迄今，在PNAS、the Lancet Infectious Diseases和Molecular Biology and Evolution等国际顶级学术期刊杂志发表论文多篇，SCI论文四十余篇，影响因子10及以上有10篇，得到寄生生物领域国内外同行认可。
研究成果加深了学术界对寄生生物的生物学特性在细胞，蛋白及分子水平上的认识，在物种形成及进化等宏观方面做出了积极贡献，也为寄生虫的控制及药物靶点设计提供了重要的理论基础。
承担课题
主持的科研基金:
2018–2021国家自然科学基金面上项目(31772445)
利用iNOS基因敲除大鼠研究宿主NO对弓形虫增殖与分化的调控
2016–2020广东省自然科学基金杰出青年项目(2016A030306048)
人畜共患病原体锥虫的遗传特性及分化调控
2015–2018广州市珠江科技新星专项项目(201506010011)
人畜共患锥虫的遗传特性及分化调控
2015–2018广东省自然科学基金面上项目(2014A030313164)
利用布氏锥虫BBCP蛋白研究真核生物中心体的蛋白组成及蛋白功能
2015 – 2017国家自然科学基金青年项目(31402029)
利用布氏锥虫BBCP蛋白研究真核生物中心体的蛋白组成及蛋白功能
参加的科研基金:
2017–2020国家重点研发计划畜禽重大疫病防控与高效安全养殖综合技术研发(2017YFD0500400)畜禽重要胞内寄生原虫的寄生与免疫机制研究1856万
2016–2018国家重点研发计划生物安全关键技术专项(2016YFC1200500)重要热带病传播相关的入侵媒介生物及其病原体的生物学特性研究1277万
2015–2018广东省自然科学基金重点项目(2015A030311042)
布氏锥虫分化机理的分子基础
论文专著
Gao JM#, He ZH#, Xie YT, Hide G, Lai DH*, Lun ZR* (2019) The association between Toxoplasma gondii infection and postpartum blues. J. Affect. Disorders 250:404–409.
Zhang X, Li SJ, Li Z, He CY, Hide G, Lai DH*, Lun ZR* (2019) Cell cycle and cleavage events during in vitro cultivation of bloodstream forms of Trypanosoma lewisi, a zoonotic pathogen. Cell Cycle. 18(5):552–567. doi: 10.1080/15384101.2019.1577651
Bando H, Sakaguchi N, Lee Y, Pradipta A, Ma JS, Tanaka S, Lai DH, Liu J, Lun Z-R, Nishikawa Y, Sasai M and Yamamoto M (2018) Toxoplasma effector TgIST targets host IDO1 to antagonize the IFN-g-induced anti-parasitic response in human cells. Front. Immunol. 9:207 doi: 10.3389/fimmu.2018.02073
An R, Tang Y, Chen L, Cai H, Lai DH, Liu K, Wan L, Gong L, Yu L, Luo Q, Shen J, Lun ZR, Ayala FJ, Du J. (2018) Encephalitis is mediated by ROP18 of Toxoplasma gondii, a severe pathogen in AIDS patients. Pro. Nat. Acad. Sci. USA. 115(23):E5344–E5352. doi: 10.1073/pnas.1801118115
Zhang X, Hong XK, Li SJ, Lai DH, Hide G, Lun ZR, Wen YZ. (2018) The effect of normal human serum on the mouse trypanosome Trypanosoma musculi in vitro and in vivo. Exp. Parasitol. 184:115–120.
Shen J#, Lai DH#, Wilson RA, Chen YF, Wang LF, Yu ZL, Li MY, He P, Hide G, Sun X, Yang TB, Wu ZD*, Ayala FJ*, Lun ZR*. (2017) Nitric oxide blocks the development of the human parasite Schistosoma japonicum. Proc. Natl. Acad. Sci. USA. 114 (38): 10214–10219. doi: 10.1073/pnas.1708578114. (影响因子: 9.6) 2017.9.5
Hong XK, Zhang X, Fusco OA, Lan YG, Lun ZR, Lai DH*(通讯作者). (2017) PCR-based identification of Trypanosoma lewisi and Trypanosoma musculi using maxicircle kinetoplast DNA. Acta Tropica. 171:207–212. (影响因子: 2.4)
Li K, Zhou S, Guo Q, Chen X, Lai DH, Lun ZR, Guo X. (2017) The eIF3 complex of Trypanosoma brucei: composition conservation does not imply the conservation of structural assembly and subunits function. RNA. 23(3):333–345. doi: 10.1261/rna.058651.116. Mar (影响因子: 3.7)
Li Z, Guo Q, Zheng L, Ji Y, Xie YT, Lai DH, Lun ZR, Suo X, Gao N. (2017) Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii. Cell Res. doi: 10.1038/cr.2017.104. (影响因子: 7.3)
Xie YT, Gao JM, Wu YP, Tang P, Hide G, Lai DH*(通讯作者), Lun ZR*. (2017) Recombinant α-actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis. Parasits Vectors. 10(1):83. doi: 10.1186/s13071-017-2009-8. 2017 Feb 16 (影响因子: 3.23)
Gao JM, Xie YT, Xu ZS, Chen H, Hide G, Yang TB, Shen JL, Lai DH*(通讯作者), Lun ZR*.(2017) Genetic analyses of Chinese isolates of Toxoplasma gondii reveal a new genotype with high virulence to murine hosts. Vet. Parasitol. 241:52–60. doi: 10.1016/j.vetpar.2017.05.007. 2017 Jul 15. (影响因子: 2.5)
Qin A(共一), Lai DH(共一), Liu Q, Huang W, Wu Y, Chen X, Yan S, Xia H, Hide G, Lun ZR*, Ayala FJ*, Xiang* AP. (2017) Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against Toxoplasma gondii. Proc. Natl. Acad. Sci. USA. 114(6):1365–1370. (影响因子: 9.6) 2017.2.7
Wen YZ, Su BX, Lyu SS, Hide G, Lun ZR, Lai DH*. (2016) Trehalose, an easy, safe and efficient cryoprotectant for the parasiticprotozoan Trypanosoma brucei. Acta Tropica 164, 297–302. (影响因子: 2.4) Dec
赖德华，吴娜，谢祎婷，洪晓昆，陈允甫，廖力夫，伦照荣*. (2016)一例输入性皮肤利什曼病病原体的鉴定. 中国寄生虫学与寄生虫病杂志34(3):295–296,封3. [Lai DH, Wu N, Xie YT, Hong XK, Chen YF, Liao LF, Lun ZR*. (2016) Pathogen Identification in an Imported Case of Cutaneous Leishmaniasis. Chin. J. Parasitol. Parasit. Dis. 34(3):295-296.] Jun 国家核心期刊
Wen YZ, Lun ZR, Zhu XQ, Hide G, Lai DH*. (2016) Further evidence from SSCP and ITS DNA sequencing support Trypanosoma evansi and Trypanosoma equiperdum as subspecies or even strains of Trypanosoma brucei. Infect. Genet. Evol. 41:56–62. (影响因子: 3.0) July
Lai DH*, Hong XK, Su BX, Liang C, Hide G, Zhang X, Yu X, Lun ZR. (2016) Current status of Clonorchis sinensis and clonorchiasis in China. Trans. R. Soc. Trop. Med. Hyg. 110:21–27. (影响因子: 1.8) Jan
Lin RH, Lai DH*, Zheng LL, Wu J, Lukeš J, Hide G, Lun ZR* (2015). Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen. Parasit. & Vectors 8:665. (影响因子: 3.2) Dec
Lun ZR*, Lai DH, Wen YZ, Zheng LL, Shen JL, Yang TB, Zhou WL, Qu LH, Hide G*, Ayala FJ* (2015) Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii. Proc. Natl. Acad. Sci. USA. July 112(29):8835–8842. (影响因子: 9.6)
Flegontov P, Michalek J, Janouskovec J, Lai DH, Jirku M, Hajduskova E, Tomcala A, Otto TD, Keeling PJ, Pain A, Obornik M, Lukes J (2015) Divergent Mitochondrial Respiratory Chains in Phototrophic Relatives of Apicomplexan Parasites. Mol. Biol. Evol. May. 32(5): 1115–1131. DOI: 10.1093/molbev/msv021 (影响因子: 10.4)
Carnes J, Anupama A, Balmer O, Jackson A, Lewis M, Brown R, Cestari1 I, Desquesnes M, Gendrin C, Hertz-Fowler C, Imamura H, Ivens A, Koreny L, Lai DH, MacLeod A, McDermott SM, Merritt C, Monnerat S, Moon W, Myler P, Phan I, Ramasamy G, Sivam D, Lun ZR*, Lukeš J*, Stuart K*, Schnaufer A* (2015) Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty. PLOS Negl. Trop. Dis. 9(1):e3404. (影响因子:4.4)
Gao JM, Yi SQ, Wu MS, Geng GQ, Shen JL, Lu FL, Hide G, Lai DH(共同通讯作者), Lun ZR* (2015) Investigation of infectivity of neonates and adults from different rat strains to Toxoplasma gondii Prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection. Exp. Parasitol. 149(1): 47–53. (影响因子: 1.6)
Xie YT, Lai DH, Liu GY, Zhou JL, Lun ZR* (2015) Severe fever with thrombocytopenia syndrome in China. Lancet Infect. Dis. February 15(2): 145. (影响因子: 4)
Lun ZR, Wen YZ, Uzureau P, Lecordier L, Lai DH, Lan YG, Desquesnes M, Geng GQ, Yang TB, Zhou WL, Jannin JG, Simarro PP, Truc P, Vincendeau P, Pays E. (2015) Resistance to normal human serum reveals Trypanosoma lewisi as an underestimated human pathogen. Mol. Biochem. Parasitol. 199(1):58-61. (影响因子: 2.9)
Lai DH, Poropat E, Pravia C, Landoni M, Couto AS, Pérez Rojo FG, Fuchs AG, Dubin M, Elingold I, Rodríguez JB, Ferella M, Esteva MI, Bontempi EJ*, Lukeš J* (2014) Solanesyl diphosphate synthase, an enzyme of the ubiquinone synthetic pathway, is required throughout the life cycle of Trypanosoma brucei. Euk. Cell Feb 13(2): 320–328. (影响因子: 3.6)
Desquesnes M, Holzmuller P, Lai DH, Dargantes A, Lun ZR, Jittapalapong S (2013) Trypanosoma evansi and surra: A review and perspectives on origin, history & distribution, taxonomy, morphology, hosts and pathogenic effects. BioMed. Res. Int. 194176 Aug 19 (影响因子: 2.9)
Desquesnes M, Holzmuller P, Lai DH, Dargantes A, Lun ZR, Jittapalapong S (2013) Trypanosoma evansi and surra: A review and perspectives on transmission, epidemiology and control, impact, and zoonotic aspects. BioMed. Res. Int. 321237 Sep 18 (影响因子: 2.9)
Janouskovec J, Sobotka R(equal contribution), Lai DH (共同第一作者), Flegontov P, Koník P, Komenda J, Ali S, Prásil O, Pain A, Oborník M, Lukes J, Keeling PJ (2013) Split photosystem protein, linear-mapping topology and growth of structural complexity in the plastid genome of Chromera velia. Mol. Biol. Evol. Nov;30(11):2447–62. doi: 10.1093/molbev/mst144. (影响因子: 10.4)
Chen Y, Wen T, Lai DH, Wen YZ, Wu ZD, Yang TB, Yu XB, Hide G, Lun ZR (2013) Development and evaluation of loop-mediated isothermal amplification (LAMP) for rapid detection of Clonorchis sinensis from its first intermediate hosts, freshwater snails. Parasitology. 2013 Sep;140(11):1377–83. doi: 10.1017/S0031182013000498. (影响因子: 2.4)
Lai DH (共同通讯作者), Bontempi EJ(共同通讯作者), Lukeš J (2012) Trypanosoma brucei solanesyl-diphosphate synthase localizes to the mitochondrion. Mol. Biochem. Parasitol. 183(2):189–192. (影响因子: 2.9)
Wang MH, Wen YZ, Wei Y, Lai DH, Bengaly Z, Desquesnes M, Lun ZR (2012) Mitogen-activated protein kinase 5, a novel molecular marker for the identification and detection of Trypanozoon species Acta Trop. 122(2):183–188. (影响因子: 2.3)
余新炳沈继龙 主编 赖德华 等编者 (2011) 现代病原生物学研究技术人民卫生出版社专著
Wang QP, Lai DH, Li Z, Li FJ, Lun ZR (2011). Semicarbazide-sensitive amine oxidase kills African trypanosomes in vitro. Acta Trop. 2011 Feb 117(2): 161–164. (影响因子:2.3 )
Oborník M, Vancová M, Lai DH, Janouškovec J, Keeling PJ, Lukeš J (2011). Morphology and ultrastructure of multiple life cycle stages of the photosynthetic relative of apicomplexa, Chromera velia. Protist 2011 Jan 162(1): 115–130. (影响因子: 3.3)
Lun ZR, Lai DH (共同第一作者), Li FJ, Lukeš J, Ayala FJ. (2010) Trypanosoma brucei: two steps to spread out from Africa. Trends Parasitol. 2010 Sep 26(9): 424–427. (影响因子: 4.9)
Lai DH, Wang QP, Li Z, Lukins AG, Reid SA, Lun ZR. (2010) Investigations into human serum sensitivity expressed by stocks of Trypanosoma brucei evansi. Int. J. Parasitol. 40(6): 705–710. (影响因子: 3.8)
Hashimi H, Benkovičová V, Čermáková P, Lai DH, Horváth A, Lukeš J. (2010) The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei. Int. J. Parasitol. 40(1): 45–54. (影响因子: 3.8)
Lun ZR, Reid SA, Lai DH, Li FJ. (2009) Atypical human trypanosomiasis: a neglected disease or just an unlucky accident? Trends Parasitol. Mar 25(3): 107–108. (影响因子: 4.9)
Lai DH(通讯作者), Wang QP, Li Z, Lukeš J, Lun ZR. (2009) Evolution of the serum resistance-associated SRA gene in African trypanosomes. Chin. Sci. Bull. 54(7):1275–1278. (影响因子: 1.0)
Lai DH, Hashimi H, Lun ZR, Ayala FJ, Lukeš J. (2008) Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei. Proc. Natl. Acad. Sci. USA 105(6): 1999–2004. (影响因子: 9.6)
Lai DH, Wang QP, Chen W, Cai LS, Wu ZD, Zhu XQ, Lun ZR. (2008) Molecular genetic profiles among individual Clonorchis sinensis adults collected from cats in two geographic regions of China revealed by RAPD and MGE-PCR methods. Acta Trop. 107(2): 213–216. (影响因子: 2.2)
Wang QP, Lai DH, Zhu XQ, Chen XG, Lun ZR. (2008) Human angiostrongyliasis. Lancet Infect. Dis. Aug 8(10): 621–630. (影响因子: 16.1)
Li FJ, Gasser RB, Lai DH, Claes F, Zhu XQ and Lun ZR. (2007) PCR approach for the detection of Trypanosoma brucei and T. equiperdum and their differentiation from T. evansi based on maxicircle kinetoplast DNA. Mol. Cell. Probes Feb 21(1): 1–7. (影响因子: 1.8)
Li FJ, Lai DH, Lukeš J, Chen XG and Lun ZR. (2006) Doubts about Trypanosoma equiperdum strains classed as Trypanosoma brucei or Trypanosoma evansi. Trends Parasitol. 22(2): 55–56. (影响因子: 4.9)
戴晓俐, 赖德华, 伦照荣. (2006) 四种抗寄生原虫药物对伊氏锥虫、马媾疫锥虫和布氏锥虫感染的治疗作用. 热带医学杂志 6卷12期1240-1244,1248国家核心期刊
Zhu S, Lai DH, Li SQ and Lun ZR. (2006) Stimulative effects of insulin on Toxoplasma gondii replication in 3T3-L1 cells. Cell Bio. Int. Feb 30(2): 149–153. (影响因子: 1.7) SCI E
Lun ZR, Gasser RB, Lai DH, Li AX, Zhu XQ, Yu XB and Fang YY. (2005) Clonorchiasis: a key foodborne zoonosis in China. Lancet Infect. Dis. 5(1): 31–41. (影响因子: 10.8)