郑乐民

北京大学心血管研究所副所长
郑乐民，男，研究室主任，研究员，博士生导师，专业为病理生理学。现任北京大学心血管研究所副所长，教育部重点实验室主任助理。心血管代谢与蛋白质组学研究室主任。中华医学会心血管分会基础学组委员；中国心胸血管麻醉学会精准医学分会副秘书长；北京生理协会血管分会脂质代谢组组长；中国药理学会心血管药理专业委员会委员；中国病理生理协会青年委员。曾任中国研究型医院协会心血管循证和精准医学专业委员会副主任委员；中国脂质与脂蛋白专业委员会青年副主任委员；
研究方向：
1.代谢与心脑血管疾病研究。代谢与心脑血管疾病研究密切相关，心脑血管疾病（包括心梗与中风）的发生发展与预后都有代谢的参与，代谢调控是基因与蛋白调控之后一个重要的研究领域。我们团队也先后发现了一些代谢分子以及相关蛋白对心脑血管疾病的新的病理生理机制与临床相关研究，其中包括琥珀酸代谢、脂代谢与脂蛋白等信号通路对于心脑血管系统的影响。
2.肠道菌群代谢。肠道菌群是一个复杂的系统，它存在着稳态与非稳态的平衡，这些平衡的打破能够带来不同的代谢物，由于这些代谢物的存在，从而影响到了肠道之外的其他器官，比如心脑血管系统等，从而产生了肠心轴、肠脑轴、肠肝轴等新的理论体系。我们团队发现了一系列新的肠道菌群代谢物例如TMAVA(三甲基-5-氨基戊酸)对心脏以及肝脏的病理生理作用，也发现了已经被大家熟知的TMAO（氧化三甲胺）新的病理生理功能比如在卒中与肺动脉高压中的新机制。
3.代谢对其他疾病的研究。代谢除了对心脑血管疾病产生巨大作用外，代谢性疾病也会影响到心脑血管疾病之外的疾病例如糖尿病。同时代谢方面的机制不但能影响到糖尿病肾病、脂肪肝等代谢性疾病，还能通过代谢通路影响到肿瘤中的血管新生以及肿瘤。通过代谢的干预以及代谢相关调控，我们能够对疾病的治疗提供新的思路与见解。
4.结合新材料新技术开展心脑血管相关的转化研究。心脑血管功能方面的应用，包括治疗与体外诊断技术的应用与研究。结合纳米技术与探针材料开展对心脑血管的诊断与治疗研究，对特定细胞例如炎症细胞等进行标记，对特定细胞进行药物运输，使得心脑血管的诊断与治疗能够在新赛道上继续发展。开展包括生物质谱技术在内的诊断学研究，将新的监测与诊断技术应用在心脑血管疾病的预防与预后上。
个人经历
2018年担任北京大学心血管研究所副所长，教育部重点实验室主任助理。
2014年担任博士生导师；2015年担任北京大学基础医学院研究员，博士生导师，研究室主任。
2007.11-2015.5作为北京大学医学部“985工程”引进人才进入北京大学医学部担任副教授与研究室主任。
2005.3-2007.10，PrognostiX Inc.（现为克利夫兰医院所属Cleveland Heart Lab），研究科学家。
2001.5-2005.3，克利夫兰医院细胞生物系，蛋白质组学中心，心血管诊断和防治中心，研究助理。
2000.8-2001.5，克利夫兰州立大学化学系，教学助理。
1998.7-2000.7，中国科学院感光化学所，科研管理。
2000.8-2005.5 在美国第四大医院克利夫兰医院（Cleveland Clinic）/美国克利夫兰州立大学留学，2005.5获得临床生物分析化学博士。
1998.7毕业于北京师范大学化学系获学士学位。
40篇代表SCI论文（*作为责任作者）：
1. Mingming Zhao, Haoran Wei, Chenze Li, Rui Zhan, Changjie Liu, Jianing Gao, Yaodong Yi, Xiao Cui, Wenxin Shan, Liang Ji, Bing Pan, Si Cheng, Moshi Song, Haipeng Sun, Huidi Jiang, Jun Cai, Minerva Garcia-Barrio, Y. Eugene Chen, Xiangbao Meng, Erdan Dong, *Dao Wen Wang,*Lemin Zheng. Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy.Nature Communications.2022 Apr 1;13(1):1757.(IF=17.7,中科院一区)
2. Yang Y#, Zeng Q#, Gao J#, Yang B, Zhou J, Li K, Li L, Wang A, Li X, Liu Z, Luo Q, Zhao Z, Liu B, Xue J, Jiang X, Konerman MC,*Zheng L, *Xiong C. High-circulating gut microbiota-dependent metabolite trimethylamine N-oxide is associated with poor prognosis in pulmonary arterial hypertension.European Heart Journal Open. 2022 Mar 29;2(5):oeac021.
3. Xu J#, Hao X#, Zhan R#, Jiang X, Jin A, Xue J, Cheng A, Liu J, Lin J, Meng X, Li H,*Zheng L,*Wang Y. Effect of Lipoprotein(a) on Stroke Recurrence Attenuates at Low LDL-C (Low-Density Lipoprotein) and Inflammation Levels.Stroke. 2022 Apr 12:101161STROKEAHA121034924.(IF=10.2，中科院一区)
4. Xiao-Xiao Chen, Yufei Wu, Xiaoxiao Ge, Liandi Lei, Li-Ya Niu, Qing-Zheng Yang,*Lemin Zheng,In vivo imaging of heart failure with preserved ejection fraction by simultaneous monitoring of cardiac nitric oxide and glutathione using a three-channel fluorescent probe,Biosensors and Bioelectronics, Volume 214, 2022, 114510, ISSN 0956-5663, https://doi.org/10.1016/j.bios.2022.114510.（IF=12.5,中科院一区）
5. Cui H#, Chen Y#, Li K, Zhan R, Zhao M, Xu Y, Lin Z, Fu Y, He Q, Tang PC, Lei I, Zhang J, Li C, Sun Y, Zhang X, Horng T, Lu HS, Chen YE, Daugherty A, *Wang D,*Lemin Zheng. Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection.European Heart Journal.2021 Nov 7;42(42):4373-4385.(IF=35.9,中科院一区)
6. Jiang X, Xu J, Hao X, Xue J, Li K, Jin A, Lin J, Meng X,*Zheng L, *Wang Y. Elevated lipoprotein(a) and lipoprotein-associated phospholipase A2 are associated with unfavorable functional outcomes in patients with ischemic stroke.Journal of Neuroinflammation.2021 Dec 28;18(1):307.(IF=9.6)
7. Xu J#, Zhao M#, Wang A, Xue J, Cheng S, Cheng A, Gao J, Zhang Q, Zhan R, Meng X, Xu M, Li H,Zheng L*, Wang Y*. Association Between Plasma Trimethyllysine and Prognosis of Patients With Ischemic Stroke.Journal of the American Heart Association.2021 Dec 7;10(23):e020979.(IF=6.1)
8. Xu J#, Cheng A#, Song B, Zhao M, Xue J, Wang A, Dai L, Jing J, Meng X, Li H,*Zheng L, *Wang Y. Trimethylamine N-Oxide and Stroke Recurrence Depends on Ischemic Stroke Subtypes.Stroke. 2021 Nov 19:STROKEAHA120031443.(IF=10.2，中科院一区)
9. Li C#, Zhao M#, Xiao L, Wei H, Wen Z, Hu D, Yu B, Sun Y, Gao J, Shen X, Zhang Q, Cao H, Huang J, Huang W, Li K, Huang M, Ni L, Yu T, Ji L, Xu Y, Liu G, Konerman MC,*Lemin Zheng, *Wang D. Prognostic Value of Elevated Levels of Plasma N-Acetylneuraminic Acid in Patients With Heart Failure.Circulation: Heart Failure.2021 Nov;14(11):e008459（IF=10.4）
10. Wu L#, Liu C#, Chang D Y, Zhan R, Zhao M, Lam S M, Shui G, Zhao M H,*Lemin Zheng, *Chen M. The attenuation of diabetic nephropathy by annexin A1 via regulation of lipid metabolism through AMPK/PPARα/CPT1b pathway.Diabetes.2021 Oct;70(10):2192-2203.(IF=9.3，中科院一区)
11. Wei H#, Zhao M#, Huang M, Li C, Gao J, Yu T, Zhang Q, Shen X, Ji L, Ni L, Zhao C, Wang Z, Dong E,Zheng L*, Wang DW*. FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction: evidence from an Asian population.Frontiers of Medicine. 2021 Jun 22.（IF=9.9）
12. Zhou C, Lin Z, Cao H, Chen Y, Li J, Zhuang X, Ma D, Ji L, Li W, Xu S, *Pan B,*Lemin Zheng. Anxa1 in smooth muscle cells protects against acute aortic dissection.Cardiovascular Research. 2021 Mar 23:cvab109.(IF=13.1，中科院一区)
13. Jingxuan Li#, Yingyu Chen#, Jianing Gao, Yue Chen, Changping Zhou, Xin Lin, Changjie Liu, Mingming Zhao, Yangkai Xu, Liang Ji, Zongzhe Jiang, *Bing Pan,*Lemin Zheng. Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b.Cardiovascular Research. 2021 Jan 21;117(2):450-461.(IF=13.1，中科院一区)
14. Man Z, Cui H, Lv Z, Xu Z*, Wu Z, Wu Y, Liao Q, Liu M, Xi P*,Zheng L*, Fu H*. Organic Nanoparticles-Assisted Low-Power STED Nanoscopy.Nano Letters.2021 Apr 28;21(8):3487-3494.(IF=12.3，中科院一区)
15. Wu L#, Liu C#, Chang DY, Zhan R, Sun J, Cui SH, Eddy S, Nair V, Tanner E, Brosius FC, Looker HC, Nelson RG, Kretzler M, Wang JC, Xu M, Ju W, Zhao MH, *Chen M,*Lemin Zheng. Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy.Kidney International. 2021 Jul;100(1):107-121.(IF=19.0，中科院一区)
16. Zhang M#, Gao J#, Zhao X, Zhao M, Ma D, Zhang X, Tian D, Pan B, Yan X, Wu J, Meng X, Yin H,*Lemin Zheng. p38α in macrophages aggravates arterial endothelium injury by releasing IL-6 through phosphorylating megakaryocytic leukemia 1.Redox Biology.2021 Jan;38:101775.(IF=10.8，中科院一区)
17. Jian Kong#, Changyu Yao#, Shuying Dong#, Shilun Wu, Yangkai Xu, Ke Li, Liang Ji, Qiang Shen, Qi Zhang, Rui Zhan, Hongtu Cui, Changping Zhou, Haigang Niu, Guoming Li, *Wenbing Sun,*Lemin Zheng. ICAM-1 Activates Platelets and Promotes Endothelial Permeability through VE-cadherin after Insufficient Radiofrequency Ablation.Advanced Science. 2021 Jan 4;8(4):2002228.(IF=17.5，中科院一区)
18. Mingming Zhao#, Lin Zhao#, Xuelian Xiong, Yuan He, Wei Huang, Zihao Liu, Liang Ji, Bing Pan, Xuefeng Guo, Leibo Wang, Si Cheng, Ming Xu, Hongyuan Yang, Yuxin Yin, Minerva T. Garcia-Barrio, Y. Eugene Chen, Xiangbao Meng,*Lemin Zheng. TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice.Gastroenterology. 2020 Jun;158(8):2266-2281.(IF=33.9，中科院一区)
19. Xiaoxiao Ge#, Hongtu Cui#, Jian Kong, Shi-Yu Lu, Rui Zhan, Jianing Gao, Yangkai Xu, Shuangyan Lin, Kaixin Meng, Lingyun Zu, Shaojun Guo,*Lemin Zheng. A Non-Invasive Nanoprobe for In Vivo Photoacoustic Imaging of Vulnerable Atherosclerotic Plaque.Advanced Material. 2020 Sep;32(38):e2000037.(IF=32.1，中科院一区)
20. Zheng Lv#, Zhongwei Man#, Hongtu Cui, Zhenzhen Xu*, Huanhuan Cao, Shuai Li, Qing Liao, Qihua He,Lemin Zheng*, and Hongbing Fu*. Red AIE Luminogens with Tunable Organelle Specific Anchoring for Live Cell Dynamic Super Resolution Imaging.Advanced Functional Materials.2020,31(10), 2009329.(IF=19.9，中科院一区)
21. Zheng Lv #, Li Li#, Zhongwei Man, Zhenzhen Xu*, Hongtu Cui, Rui Zhan, Qihua He,*Lemin Zheng, Hongbing Fu*. Polarity-activated super-resolution imaging probe for the formation and morphology of amyloid fibrils.Nano Research. 2020,13(9): 2556-2563.(IF=10.3，中科院一区)
22. Jianping Li#, Changping Zhou#, Hongbing Xu#, Robert Brook, Shengcong Liu, Tieci Yi, Yang Wang, Baihuan Feng, Mingming Zhao, Xu Wang, Qian Zhao, Jie Chen, Xiaoming Song, Tong Wang, Shuo Liu, Yi Zhang, Rongshan Wu, Jianing Gao, Bing Pan, Subramaniam Pennathur, Sanjay Rajagopalan, Yong Huo,*Lemin Zheng, *Wei Huang. Ambient Air Pollution is Associated with High-Density Lipoprotein Dysfunction in Healthy Adults.Arteriosclerosis, Thrombosis, and Vascular Biology. 2019 Mar;39(3):513-522.（IF=10.5）
23. Man Z#, Lv Z#, *Xu Z, Cui H, Liao Q,Zheng Lemin*, Jin X, He Q, Fu H*. Organic nanoparticles with ultrahigh stimulated emission depletion efficiency for low-power STED nanoscopy.Nanoscale. 2019;11(27):12990-12996.(IF=8.3，中科院一区)
24. He D#, Zhao M#, Wu C, Zhang W, Niu C, Yu B, Jin J, Ji L, Willard B, Mathew A, Chen Y, Pennathur S, Yin H, He Y, *Pan B,*Lemin Zheng. Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing and compromises reendothelialization impaired by oxidized HDL through SR-B1.Redox Biology.2018 May;15:228-242.(IF=10.8，中科院一区)
25. Zhan R, Zhao M, Zhou T, Chen Y, Yu W, Zhao L, Zhang T, Wang H, Yang H, Jin Y, He Q, Yang X, Guo X, Willard B, Pan B, Huang Y, Chen Y, *Chui D,*Lemin Zheng. Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation.Cell Death & Disease. 2018 Jun 7;9(6):683.（IF=9.7）
26. Li D#, Ke Y#, Zhan R, Liu C, Zhao M, Zeng A, Shi X, Ji L, Cheng S, Pan B, *Lemin Zheng, *Hong H. Trimethylamine-N-oxide promotes brain aging and cognitive impairment in mice.Aging Cell. 2018 Aug;17(4):e12768.(IF=11.0)
27. Liu D#, Ji L#, Zhao M, Wang Y, Guo Y, Li L, Zhang D, Xu L, Pan B, Su J, Xiang S, Pennathur S, Li J, Gao J, Liu P, *Willard B,*Lemin Zheng. Lysine glycation of apolipoprotein A-I impairs its anti-inflammatory function in type 2 diabetes mellitus.Journal of Molecular and Cellular Cardiology.2018 Sep;122:47-57.
28. Ke Y#, Li D#, Zhao M, Liu C, Liu J, Zeng A, Shi X, Cheng S, Pan B,*Lemin Zheng, *Hong H. Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress.Free Radical Biology and Medicine. 2018 Jan 8;116:88-100.
29. Lu J#, Chen B#, Chen T, Guo S, Xue X, Chen Q, Zhao M, Xia L, Zhu Z, *Lemin Zheng, *Yin H. Comprehensive metabolomics identified lipid peroxidation as a prominent feature in human plasma of patients with coronary heart diseases.Redox Biology.2017 Aug;12:899-907.(IF=10.8，中科院一区)
30. Feng C, *Xu Z, Wang X, Yang H,*Lemin Zheng, *Fu H. Organic-nanowire-SiO2 core-shell microlasers with highly polarized and narrow emissions for biological imaging.ACS Applied Materials & Interfaces.2017.Mar 1;9(8):7385-7391.(IF=10.4)
31. Zhang H, Wang X, Liao Q, Xu Z, Li H,*Lemin Zheng, *Fu H. Embedding Perovskite Nanocrystals into a Polymer Matrix for Tunable Luminescence Probes in Cell Imaging.Advanced Functional Materials.2017 Feb;27(7):1604382.(IF=19.9，中科院一区)
32. Zhang X#, Wang X#, Hu F, Zhou B, Chen HB, Zha D, Liu Y, Guo Y,*Lemin Zheng,*Xiu J. A novel hydrodynamic approach of drag-reducing polymers to improve left ventricular hypertrophy and aortic remodeling in spontaneously hypertensive rats.International Journal of Nanomedicine.2016 Dec 13;11:6743-6751.
33. Mingli Peng, Houli Li, Zhiyi Luo, Jian Kong, Yinsheng Wan,*Lemin Zheng, Qinlu Zhang, Hongxin Niu, Alphons Vermorken, Wim Van de Ven, Chao Chen, Xikun Zhang, Fuqiang Li, Lili Guo, Yali Cui*. Dextran-coated superparamagnetic nanoparticles as potential cancer drug carriers in vivo.Nanoscale.2015 Jul 7;7(25):11155-62.
34. Haitao Shen#, Enchen Zhou, Xiujing Wei, Zhiwei Fu, Chenguang Niu, Yang Li, Bing Pan, Anna V Mathew, Xu Wang, Subramaniam Pennathur,*Lemin Zheng,*Yongyu Wang. High density lipoprotein promotes proliferation of adipose-derived stem cells via S1P1 receptor and Akt, ERK1/2 signal pathways.Stem Cell Research & Therapy.2015 May 15;6:95.
35. Lei Huang#, Chenguang Niu, Belinda Willard, Weimin Zhao, Lan Liu, Wei He, Tianwen Wu, Shulin Yang, Shutang Feng1, *Mu Yulian,*Lemin Zheng, *Li Kui. Proteomic analysis of porcine mesenchymal stem cells derived from bone marrow and umbilical cord: Implication of the proteins involved in the higher migration capability of bone marrow mesenchymal stem cell.Stem Cell Research & Therapy.2015 Apr 15;6:77.
36. Tong X, Lv P, Mathew AV, Liu D, Niu C, Wang Y, Ji L, Li J, Fu Z, Pan B, Pennathur S,*Lemin Zheng, *Huang Y. The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus.Cardiovascular Diabetology. 2014 Apr 21;13(1):82.
37. Kong J, Kong F, Gao J, Zhang Q, Dong S, Gu F, Ke S, Pan B, Shen Q, Sun H,*Lemin Zheng, Sun W*, YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma.Molecular Cancer. 2014 Jan 13;13:7.(IF=41.4，中科院一区)
38. Tong X#, Peng H, Liu D, Ji L, Niu C, Ren J, Pan B, Hu J,*Lemin Zheng, *Huang Y. High-density lipoprotein of patients with Type 2 Diabetes Mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate.Cardiovasc Diabetol.2013 Jan 30;12(1):27.
39. Pan B#, Ren H#, He Y, Lv X, Ma Y, Li J, Huang L, Yu B, Kong J, Niu C, Zhang Y, Sun WB,*Lemin Zheng. HDL of Patients with Type 2 Diabetes Mellitus Elevates the Capability of Promoting Breast Cancer Metastasis.Clinical Cancer Research. 2012 Mar 1;18(5):1246-56.(IF=13.8，中科院一区)
40.Lemin Zheng, Nukuna B, Brennan M, Sun M, Goormastic M, Settle M, Schmitt D, Fu X, Thomson L, Fox P, Ischiropoulos H, Smith J, Kinter M, and Hazen S. Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease.Journal of Clinical Investigation.2004 Aug;114(4):529-41.(IF=19.5，中科院一区)