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On 19 May 1961 I had a visit from Dr.Glenn E. Ullyot and Drs. Tedeschi and Loev of Smith Kline & French Laboratories, Philadelphia.

These people have become interested in the therapeutic possibilities of drugs in the cannabinol group and have synthesized a number of compounds, including the most potent compound made by Loewe. Copy of the information they supplied me is enclosed.

Naturally they are interested in the material termed SKF-5390, which is a mixture of isomers and may not be as potent as one of the materials studied by Loewe.

So far the materials have been studied only with their screening methods and they are naturally interested in the resemblance of the effects to those of the phenothiazine tranquilizers.

As yet they have not done detailed toxicology, general pharmacodynamics, neuropharmacology, or psychopharmacology on the material. They are sending me a sample of SKF-5390 and I will check it out fcr potency and for general pattern of effects.

With kindest personal regards,

Harris Isbell, M.D. darre bbece Director

HI:rn

Enclosure

B-357

196

DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE

Nedeat Intirte of Meata Henith A4dlaa Rsatà Caa U.š. Publie Heakzà Serrtce Haapical Leriagtoe, Keanczy

PUBLIC HEALTH SERVICE

22 May 1961