[PAGE 1]
MEMORANDUM POR, CHIKP, VINANCE DIVISION

MLT, Bubproject 51-B, Invoice No. 7, Al1otment 8-2502-10-001

1. Invoice No. 7 covering the above subproject is attached. Payment should be. made ae follovet

Cashier'e chock in the esount of 61,200.00, drav o0 6 bank

2. The check should bo forvaried to Chief, T8s/Chenical Division, through Tss/Budget Officer, no later than Friday, 20 June 1958.

3.-This invoico ropresente the totl emount currently authorized vnder Subprojoct 5l-B. Howover, sinco it ie enticipated that edditionel fada vili ba obligáted for this projeot, the filsg should not be closod.

HECKT RECEIVET.

Deputy Chief Tes/Chemtcal Division

Attechmente: Invoice & Certificaticne

Diatributioni Orig & 2 - Addressee

D 888002502 600.12502-10-001 17.2

#20.10
41200.00

5 Juno 1958

[PAGE 2]
(1) It 1s hereby certifiod that thie 1s Invoice No. 7 epplying to Subproject 51-B of MUlRA, that porformance ia catiafactory, that services ere being sccooplished in accorlance vith mutual agreemonte, that a detailed agenda of the payments and recoipte is on file in Te3/cD, that this bill ia fust and correct and thet peyment theeof bas not yut bocn tade.

Doputy Chief T8S/Chenical Divieton

(2) It is hereby certified that this invoice appiies to Subproject 51-B of MuLTRA which vas duly approved, and that the project is being carried out in accordance with the memorandum dated 13 April 1953 fron the DCI to the DD/A, and the extension of this authority in suboequent mamarondo

[PAGE 3]
S03I80T

• AA, EubproJeet 51-9, Adional Authorizatioa No. 3

Under tho auttority grantod in the Henoreodua dated 13 Apeil 1953, fros tho DCI to tha Lo/A and the extenolon of thie sutbority in subeeçuent menorenda, Bubprojact 51-9 vaa previovaly epproved. Vader the saun outhcrity en aaattional sws of \$1,200.00 hes been authorized to cover tho Dubprojoct's expenses (thereby tringing to 6 total of \$24,060.0o funde cbligated during Fr 59), to to chargel to Allotaent 8-2502-10-001.

Chief 189/Cheaieal Divieion

APPROVEO FOR GBLXOATION OF SUIDBI

1558 L.CERTIFY-THAT FJNDS ARE AVAICAALE ORLIGATICN REERENCE NO. CHARCE TO ALLCNIND-

3195

pletributiont Orig 4 2 = Addrevscs

1 - TSS/PASB

1 - TSS/SRB

2 - TSS/CD

MONOSANDUM FOS: COHTROLLER

[PAGE 5]
I propose, in the capacity-of-chief-investigator, to pursue in the period September 1, 1958 to August 31,-1959,- a program of research comprising the following activitles:

1.Chemical investigations-of-the-pharmacologically active constituents of various plants and fungi.

2. Investigations-on the chemistry of new heterocyclic compounds of-potential-pharmacological interest.

3. Synthesis of miscellaneous compounds of-pharmacologtcal interest.

It is expected that the following budget wili be required for-these purposes:

Principal Investigator (summer)\$ 1,800

Post-doctoral-fellow: 4,200

Pre-doctoral·fellow: 1,800

Total Salaries .\$ 7,800

Overhead (25% of salaries) 1,950

June 30, 1958

A PROPOSAL FOR CONTINUATION OF GRANT

[PAGE 6]
Supplies and Equipment \$2,000
Services. (analytical, secretarial,etc.)1,000
Travel 500

[PAGE 7]
propose, in the capacity of chief investigator, to pursue 1n the perlod September 1, 1958 to August 31, 1959, a program of research comprising the following activities: Chemical investigatlons of the pharmacologically active constituents of various plants and fungl 2. Investigations on the chemistry of new heterocyclic compounds of potential pharmacological interest. 3. Synthesis of miscellaneous compounds of pharmacolog cal Interest It is-expected that the following budget.will be required for these puroosest

Principal Investigator( Post-doctoral fellow: Pre-doctoral fellow:
Total Salaries
Overhead (25% of salaries)

[PAGE 9]
I wish to thank you very, much for the 1,2-dimethylheptyl recorcinol. I have started the synthesis-of-the pyran from -it and the. process. seems to going very well so far. We are looking.forward to. seeing you again in the, we hope, not too distant future. Thank you again.

[PAGE 11]
SUBJECT

: Supplement to MULTRA, Subproject 51-B

1. The purpose of supplementing Subproject 5l-B is to provide additional funds to allow for an increase in scope of the original work. This increase. in\_scope consists of the synthesis of a number of otherwise unobtainable chemical compounds which are needed in other projects.

2. The cost of\_this\_supplement\_will not'exceed \$1,200.00 and cbarges should be made against\_ A1lotment\_8-2502-10-001. Since 16276 Subproject 51-B was originally funded for a total of \$22,880.00, 1752.4 the new total-for this subproject will now amount to \$24,080.00.

3.. All of the fiscal control and security provisions

contained in the original Memorandun for the Record on Subproject 5l-B,

dated 31 July 1957, will apply tothis\_supplement.

APPROVED FOR OBLIGATION OF FUNDS:

DRAFT 29 May 1958

MEMORANDUM FOR: - THE RECORD

[PAGE 12]
Enclosed please find two-(z) copies.of.a-proposal-which is submitting for the-continued support of-his research project.

If it meets .with your approval, please-send your usual "letter of intent" to Dr The University deeply-appreciates the help and support which the has given DoBC

Assistant Research Administrator

[PAGE 13]
TO THE

I propose, in the capacity of chief investigator, to pursue in the period Sept. 1, 1957 to Aug. 31, 1958, a program of research comprising the following activities:

1. Continuation of efforts to procure samples-of selected botanical materials of potential pharmacological interest, to arrange-for their propagation, and to investigate the principles responsible for the pharmacologlcal-activity.

2. Continuation of studies of new heterocyclic systems, with.einphasis on seven membered nitrogenous rings.

3. Provision of facilities for the synthesis.of. selected compounds of pharmacological Importance.

It is expected that the following-budget will be required for these purposes;

Salariest

Prin. Investigator Post-doctoral Feliow (1) Pre-doctoral Feliows (2) Total Salaries

\$7,000
4,200
3,600
\$14,800

July 8, 1957

A PROPOSAL FOR RENEWAL OF GRANT

[PAGE 15]
1. Invoice No. 6 covering the sbove subproject is attached. Faytent abould be aaso eo follovei

2. The chocks ahould to forvated to Chier, Too/cheaical Diviaton, theough Tss/budget Offtcer, no later than Toeoday, 6 May 1958.

3. This invoice reprosents tho total coomt currently cuthorised under Subprojoct 51-B. Hovever, since it is anticipated/that additional funds vill be obligatod for. thia project, tho filos should not te cloced.

Attachaentoi Invoice & Certifications

I CECTEY TRLAT FUNDS ARE AVAILASLE 241958
CGATC REERPNCE N. J35
CGE 10 0 350210-00
CHECKRIN THE AMOUNT OF 4166.67
RECEIVED. b8

[PAGE 16]
(1) It is hereby certified thet this ia Invoice No. 6 applying to Subproject 51-B or MOLTRA, that performance 1s satiafectory, that services ere being accomplished in accordance vith mutual agreemente, that a detailed egenda of the payments and receipts is on rile in Is/cD, thet thie bill ie just and correct cnd that payent thereof has not yet beon mode.

Chief, T6s/Cheaical Diviston

(2) It is hereby certified that thia invoico applies to Subprojeot 51-B of MULTRA vhich was duly epproved, end that the project is being carried out in aceordance with the monorandua dated 13 April 1953 from the DOI to the DD/A, and the extenaion of thie authority in eubsequent memoranda.

[PAGE 17]
RECEIPT

Receipt is hereby acknowledged of the following two checks:

[PAGE 19]
(1) It ia hereby certifled that thie is Invoice #5 applying to Subproject \$51-B of MKULTRA, that performanca is satisfactory, that eervices are being accomplished in accordance with mutual agreements, that a detailed agenda of tho payments and receipte ia on file in TSS/CD, that this bill is just and correct and that payment thereof bas not yet been made.

Acting Chief, TSS/Cherical Divisloa

(2) It is hereby cortified that this involce applles to Subproject f51-B of MKULTRA which was duly approved, and that tho project is belng carried out in accordance with the merorandum dated 13 Aprll 1953 frora the DCI to the DD/A, and the extenalon of this authority i subscquent memoranda.

[PAGE 21]
smhx chler TSS/Chanice1 Divieioa

APPROVED EOG ORJGATION OF PONDS: 2

Receärch Director J0L 31:1551

Attcchments Proposel

Piatributiont Orig 9 2 - Adáreasce

1- TSS/∝1TSS/FASB-TSS/SRB2-TSS/CD

[PAGE 23]
MKULTRA Subproject 51-A, Involce No. 4, A1lotment 7-2502-10-001

2. Please forward the checks to Chlef, TSS/Chemical Division through TSS/Budget Officer by Friday, 5 July 1957.

3. This 1s a final involce. A total of \$23,790.00 was obligated under this subproject during FY 57. However since it 1s anticlpated that additional funds will be obligated for thls project, the files should not be closedz C: RTUEAMDUNLHE EIVEDR2

Attachments: Involce & Certifications

[PAGE 24]
CERTIFICATIONS

(1) Ii 13 hereby certified that this is Invoice No. 4 applying to Subpro'ect 51-A of MKULTRA, that:performance has\_been satisfactory, that the services have been accompllshed in accordance with mutual agreements, that a detalled agenda of the payments and receipts is on file in TSS/CD, that this blll is just and correct and that payment thereof has not yet been made.

(2) It Is hereby certifled that this Involce applles to Subproject 51-A under MKULTHA which was duly approved and that the pro ject has been carrled\_out in accordance with the meniorandum dated 13 April 1953 from the DCI to the DD/A, and the extenslon of thls authority In subsequent memoranda.

Research Director

[PAGE 25]
Receipt is hereby acknowledged of the following two checka: E Orricial Check No. rawn on The in the amount 0r \$14,666.67, payable to drawn on the E to the the amount of \$586.67, payable 1B

[PAGE 27]
MKULTRA Subproject SI-A, Involce No, 3. Allotment 7-2502-10-001

Involce No. 3 covering the above subprojact ts attached. Other invoices will follow later. It is requested that payment be mada by cashler'a chccks as follows:

Check for \$7, 625.00, drawn on a Check for \$305.00, drawn on a

2 Please forward the ghecks to Chief, TSS/Chemical Divlllon throygh-T69/Budgetalicer by Friday, 21 September 1956.

SIDNEY GOTTLIEB Cbtef TSS/Cheraical Diviston

CHECK JOIN THE AMOUNT D6 SZ6S N1 RECEIVED. .0S

11 Soplember 1956

[PAGE 29]
September 10, 1956

Enclosed please find tho recelpt totalling \$5,718.75, tho quarterly paybent which covers the period September 1 to November 30, 1956.

As soon as the August fiscal statements aro available to this office, we will give you a financial statement for the past year's research expenditures. If there is an unspent balance at that time, may we suggest that you subtract it from the next payment, on December l. 1956,

The University is pleased that you are "completely satisfied with the contract". and that is conducting such a splendid research program.

Very truly yours,

Assistant Rebearch Administrator

Enclosure

[PAGE 33]
MKULTRA, Subproject 51-A

1. The purpose of Subproject 51-A is to contipue the vork of Dr. on botanical materials having a psychochemical:efrect. Dr shas been able to document the psychological-effects and to identify poeitively a species of cerennial qushroom which promises to yield a completely new chemical agent of this type.It is quite possible that the precise identity of this material,-if the vork can be successfully carried out, can remain an Agency secret.

2. The scope of this research program is outlined in detail in the accompanying proposal. It should be emphasized that item #53 therein, providing synthetic facilities, has proven to be very valuable in the past year. Oue final productsand two very useful intermediates vere securely produced at very lov cout and in a few days time by this arrangement.

22,000 : 3. The cost of this program is estimated to be \$22,875 for a four percent service charge to the Therefore, the total cost will-not exceed \$23,790.00. Charges should be made against A110tment 7-2502-10-001.22,570.00

4. The has requested the Uaiversity to submit to them a summary accounting of monies received frcm the Fund. Alsoj they requested the return of-any unexperded funds received under a grant fromthe Fund on conclusion of the program.

5. Title to any permanent equipment purchased by funds granted the Univeraity shall be retained by the University in-lieu of higher overhead. rates.

6. It vas mutually agreed that documentation and accounting for. travel expenses which are-reimbursable by theUniversity shall conform with the açcepted practices of that Institution.

27 August 1956

MEMORANDUM POR TER RECORD

[PAGE 34]
7. Dr.agreed to comply vith the requirements of the Memorandun of Agreement.

Chief, TSS/Chenical Division

APPROVED POR OBLIGATION OF. PUNDS: OF. PUNDS:

C Research Director

Date:

Distribution: Original Only TSS

[PAGE 35]
A PROPOSAL

I propose, in the capacity-of -chief investigator, to pursue in ths period Sept, 1, 1956. to Sept 1 1957 a program of research comprising thefollowingactivities.

1. The procurement of various plant materials, including some rather difficultly accessible fungal species, which have been implicated in reports to contain substances causing disturbances or changes in-the-central nervous systen;

2.·The processing of these materials by extraction and fractionation procedures, with the purpose of obtaining extracts and eventually pure compounds responsible for the biological activity, and of furnishing such-extracts for pharmacological evaluation.

3.. Determination-of the stucture of the pharmacologically important constituents of plants obtained as, described above, or other natural products obtained from various contacts in the field which are being cultivated and maintained.

4. Investigations on-the-synthesis and properties of new types of heterocyclic compounds, using as one point of departure the new diazepine ring systen which results from ring-closure of diazoacetyipyrazuzlo. sure of úiazoacetylpyrazolines -closure roactions

(1955)) and as another point ring-closure roactions of othor suitably substituted diazoketones. with the purpose of exploring both the chenistry and possible pharmacologicalusefuiness of the novol substances which can be expected to arise.

5. Provision of facilities for the-synthesis, on short not. ice, of selected compounds of particular pharmacological interest.

It is expected that the following budget wiil be required for the program outlined above:

June 13, 1956

[PAGE 41]
CERTIPICATIONS

(1) It ls hereby cortified that this ia Involce #2 applying to Subprojeot 5l of MULTRA, that performance is satisfautory, that the services are being acoomplished in accordance with mutual agreements, that a detailed agonda ct the paymenta and recoipts is on file in TSs/CD, that this bill is just and correot and that payent thereof hag not yet been made,

Aoting Chief, TSS/Chemicel Division

(2) It is heroby certified that this invoics applies to Subproject 51 under MULIRA vbioh vas duly approved and that the project is being carried out in aooordance vith the momorandum datod 13 April 1953 froa the DOI to the DD/, and the oxtension of this autbority in subsequent memoranda.

[PAGE 42]
Enclosed please find triplicate copies of the Financial Reoort for the period September l,l955\_to January 31, 1956. This Financlal Report is for the grant which supoorte fundamental research in the field of centrally active substances.

Very truly yours,

"Aseistant Research Administrator

I certify that the listed expenditures are just and reasonable and that the work has been performed satsfactorily.

Shl put SIDNEY GOTTLIEB

Chief TSS/Chemical. Division

[PAGE 45]
The purpose of this Memorandum of Agreement is to set forth -the mutual administrative responsibilities of the principal research investigator and the sponsor, Therefore, it is mutually agreed that,

A. The principal investigator shall submit to the sponsor, at-six-month-tntervals,an-informal statementsofexpenditures.of monies advanced for research activities.It is requested that the anggited statdmentsbe submitted in essentially the following fora:

Personal compensation (salaries, subject fees)
Equipment
Supplies and Services
Contingencies
Overhead

B. It is understood that any travel expenses-incurred\_in the furtherance of the research prograa will-be accounted to the University in a manner consistent with its established practices and policies.

C. The principal investigator shall submit to the sponsor seni-annual reports on the technical progress of the research covered by these funds,nd Speenfi

1 C. f garmament oquipment ni pmchond go this arjeet, tita ti it will m wit the s al a innty hile e Stnit wit ereh acent

Dato: 6 Dea. 1905

MEMORANDUM OF AGREEMENT

[PAGE 46]
MEMORANDUM FOR: THE RECORD

SUBJECT

1. This morning, Dr called me to inform us that he will be leaving on or about 30 Septemter.

2. Fe asked that I contact Dr. preferably before he leaves and cover the area of our future relations with and along the lines that Dr. Phad already covered with me.He was assured that this would bo done.,

He was-instructed to get in touch with Dr. in absence concerning any details about the rew arrangement at

SIDNEY GOTTLIER

Distribution: Orig & 2 - TSS/CD

TSSA (19 Septomber 1955)

19 Septepber-1955

[PAGE 47]
I hereby acknowledge receipt of the following:

10 Cctober 1955, dramen payable to the ,in the amount of \$213.33.

dated 10 October 1955, drawn on E payable to the ,in the amount of \$5,333.33

RECEIPT

[PAGE 49]
(1) It is hereby certifiù that thie is Invoice f1 applying to Subprojoct 51 of MXULiRA, that performance is satisfactory, that the services are being accoeplished in accordance with mutual agreeonts, that a detalled agenda of the paymenta and receipta is on file ia TSs/CD, thet this bill is just and correot and that payment thereof has not yot been made.

(2) It is hereby certified that thia invoice applies to Subproject 51 under MULIRA whioh vas duly approved and that tho project is being carried out in accordanco vith the momorandua dated 13 April 1953 fron the DCI to the DD/A, and the extension of this authority in subsequent memoranda.

[PAGE 53]
SUBJECT MKULTRA, Subproject 51

1.  The purpose of Subproject 51 is to continue work on botanical materials by Dr. formerly of the B Conpany.Dr. shas recently relocated at 7 the University

2. The scope of the research program will be to pursue
studies on the detection, isolation and chemical characteri
zation of new compounds having central nervous system effects
which may occur in various plants. The program will also
study new types of heterocyclic compounds which may be useful
in preparing centrally active agents. 025

3. The cost of this program is estimated to bo \$16,000 for a period of-one year. To this sum must be added-\$6/0 00 9/5,00 representing a four percent service charge to the Charges should be made against A1lotment- 6-2502-10-001.

fhas requested the University to submit to then a summary accounting of monies received from the Also, they requested the return of any unexpended funds received under a grant from the

5. Title to any permanent equipment purchased by funds granted the University shall be retained by the University in lieu of higher overhead rates.

6. It was mutually agreed that documentation and accounting for travel expenses which are reimbursable by the University shall confora with the accepted practices of that Institution,

15 September 1955

MEMORANDUM FOR: THE RECORD

[PAGE 54]
7. Dr agreed to comply with the requirenents of the Memorandum or Agreement.

Chief, TSS/Chenical Division

APPROVEO FOR OBLIGATION OF FUNDS:

Research

Dato: 16 Aepf. 1955.

Distribution: Original Only

TSS/CD 15 September 1955)

[PAGE 55]
It is proposed to-pursue studies on the detection,

isolation and chemical characterization of new compounds having central-nervous-systen effeots which may occur in various plants. It 1s further proposed-to-study new-types of heterocyclic compounds which may beuseful in preparing centrally-active agents.

It is expected that-the following expenses will be incurred in the course-of this program during a one year period:

Salaries . .... . . . \$ 9,600

Materials& Supplies2,000

TravelExpenses500

Overhead2,400

Miscellaneous1500

Total\$16,000

A PROPOSAL

[PAGE 59]
Project C-179 MKULTRA 51

Date Initiated: 16 September 1955

Date Expires: 1ó Septomber 1962

Fumds - current yoar: \$10,712.00

Purpose: To provido by synthosla compounds of pharmacological activity.

Status: This project is a continuing one on the preparation of compounds related to LSD and on a new hotexocyclic geries.

51-41

[PAGE 60]
51-47

[PAGE 63]
MODRAMDUM FOR : Chief, Covert Catns Branch

SUBJSCT

: MLERA Sutproject 51

Attached is a certificatioa frca Chtef, Biological Branch, for

MagRA Subproject 51 Iavoice 13 and should bo récorded in account

760.

17 FEB 1055 A
Chief, TSD/SS

57-43

17 February 1965

[PAGE 64]
CPRE71CAVTCN

2 baos revsisoi en aceonnioa rrra Sv-7zojeet 51 inics 13 1a te arert of\$ 10,300.00 sccooaties La beirs retainsd sa toe atios e? To vtors 1a cey to Pvlsead oy Mhe Certityiag Oxliser upea reqosst. X featber cortiry Oat oatlstectozy vorviea represeotod by ths encosatirg love deno aoceivel aad chat to the bas, cf sy kaovleigs tho Suols slvecoed for sch scrrlces vero ageolel Ier the yuposo fer voieh sdvezred.

16 Februry 1965

81-44

[PAGE 65]
project is A report of. expenditures for Dr. as follows:

\$10.300.00 Total Expenditures

The period covered is September 1, 1962 to August 31,

1963.

Very truly-yours,

I certify that services or materials bave been satisfactorily receiced andthe expenditures were incurred on of

Dato: 17 Filr 1965

A

[PAGE 66]
BEHAVIORAL ACTIVITIES SUPPORT BB Behavioral Control Materials (VIa) Branch Category. (formerly I1b)

project Title Chemical Synthesis Item Classifcation None

Project Crypto. MKULTRA 51B Crypto Classification. None

Branch Project No. R-97Project Engineer A

Contractor B

Contract No. N.A. Task No. N.A.

Type of ContractGovernment Stcrilc Date Initiated 11 July 1962

Cost\$10,712.00 Comapletion Date31 August 1963

Purpose:. General organic chomical synthetic.facilities for drugs and other complex compounds are maintained under this project.

Status: Satisfactorily completed.

Requirement:- Roscarch was nèeded to make new CNS active compounds that are related to ISD.

5 September 1963 Date

[PAGE 67]
SED 51-10

Date 8 April 1963

BranchBBCategory Offensive CW, BW (Anti-Personnel)(IIb

Project Title Chemical. Synthesis Item Classification None

MKULTRA\_ 51-B Crypto Classifcation None Project Crypto.

A Branch Project No.R-97 Project Fngineer

Univexsity

Contract No.N.A. Task No.

Type of Contract Government Sterile  Date Initiated 11 July 1962

31 August 1963 Cost \$10,712.00 .Completion Date

Purpose: Ceneral organic chemical synthetic facilities for drugs and otber complex compounds are maintained under this project.

Status: A critical synthetic step has been achieved in model compounds so that the total route is one-half-completed.\_

REQUIREMNT SOURCE: Researcl: was needed to make now CNS active compounds that are related to ISD.

[PAGE 68]
( A. report of expenditures :for. Dr project is as

The period covered is September 1, 196l to August 31,

I certify that Services r terials have boen satisfactorily receivpl the expefditures were incurred on officlat husiness,

[PAGE 69]
Salaries

\$ 4,246.11

Expendable Supplies and Equipment2,425.81

Chemical Analysis 316.00

Travel

Telephone

.55

Indirect Costs

1.061.53

Total: \$ 8,050.00

The period covered is September 1, 1960 to August 31,

1961.

I certify that sorutces nteraals havo beon satisfactorily received n the oxpenditures were incurred on officla. meiness

Very truly yours,

Assistant Research Administxator

[PAGE 70]
The period covered-is-September-l;- 1961 to August-3l,

Very truly yours,

Assistant Research Administrator

[PAGE 71]
\$ 4,246.11

Expendable Supplies and Equipment2425.81

Chemical Analysis 316.00

Travel

Telephone

.55

Indirect Costs

1,061.53

Total:\$ 8,050.00

The period:covered is September l, 1960 to August 31,

[PAGE 72]
RECEIPT

51-51:

Receipt is hereby acknowledged of the following checks:

Treasurer's Chcck No. dated November 8, 1962, E
in the amount of \$10, 300. 00, drawn on the payable to
Treasurer's Check No.. dated Noyember 7, 1962,
in the amount of \$412, 00, drawn on t payable to

[PAGE 74]
MEMORANDUMFOR: C/TSD/FASS

MGULTRA. Subprojact No. 51-B Additional Authorization No. 10

Undor the authority granted in the memorandum Cated 13 Aprll 1953.

frem ths DCi to the CD/A. and the extension of ths authority ia subsequens

mamoranda, Subprojoct 5l-B has-beon 202roved, an\$10,712.00

of the orar-all Prcjeec MkULTRA fosdo tave been obligateJ te eevee o

subprojeet's exenses and shouid be charged to cost cnter3l25-l390-3902

Date7 August 1962

[PAGE 76]
SUBJECT : MKULTRA, Subproject 51-B

1. The purpose of Subproject 5l-B is to continue a program of rescarch on the synthesis and properties of organic coupounds having pharmacological activities and of potential interest.

" 2. The scope-of-the-research-program-is-conçerned with studics directed to synthesis of heterocyclic and other organic compounds of potential pharmacologicel-interest and the chemical characterization of such compounds. New types of heterocyclic compounds which may be useful in-elucidating the action of known chemicalslavingcentral nervous system effects will be studied.

3. The cost of the program 1s estimated to be \$10,300.00 for a period of one year.  To this-sum must be added \$412.00 representing a four per cent service cbarge to the The total cost will not exceed \$10,712.00.—Charges should be made against Al1otment No. 3125-1390-3902.

The B that any unexpended funds be returned at the close of the grant year.

5. The requirements for a six montbs' inforual accounting on the part of the principal investigator is waived..

6. Title to any permanent equipment purchased by funds granted the University shall be retained by the University in licu of higherover-head rates. It" was mutually agreed"that"docunentation and eccounting for travel expenses which are rcimbursable by the University shall conform with the accepted practices of that institution.

MEMORANDUM FOR: THE RECORD

[PAGE 77]
agreed to comply with the requirements of the 7. Dr. Memorandurs of Agreement.

Chlef TSD/Research Branch

APPROVED FOR OBLIGATION OF FUNDS:

Attachment: Proposal

Distribution: Original only

[PAGE 78]
I propose. In the cepacity of chief investigator, to pursue In the perlod September. 1, 1962 to August 31, 1963, a program of research on the synthesis and properties of heterocyclic compounds of potential pharmacological interest.

It is expected that the following budget will be required for this purposet

June 5, 1962

A PROPOSAL FOR CONTINUATION OF GRANT

[PAGE 80]
Category Offenetvo CW. BW(Arti-Poreonel)(II-b) BranchBB

Project TitleChemfeal Syathosio-Item Classification Nono

Project CryptoMKULTRA 51-B Crypto ClassificationNono

Branch Project No..R=97. Project Engineer

Contract No.N.A. Task NoN.A,

Type of Contract Goveramcnt Sterlle Date Initiated 1 July 1962

Cost\$10.712,00 Completion Date 31 August 1963

Purpose: Generat orgaale chortcat syathetlc facllities for druge ond other complex compomads aro maintalned uador tàíe project.

Status: Syntbesls of a opeciat LSD nucleua is about one-third completed,

Date 7 Auguet 1962

[PAGE 81]
RECEIPT

Pleasr File 51-57
57

Reccipt is hereby acknowlcdged of the following checks:

Cashier's Check No. dated August in the amount of \$412, 00, drawn on B

Treasurcr'sChcck No. dated August 15,1961,
in the amount of \$9.764.43. drawn on the of the
payableto B

9764413 41二 1017643

[PAGE 84]
MEMORANOUM FORC/TSD/FASS

MKULTRA. Subprojeet No. 51-B Additional Authorization No. 10

Urdep cho autaority granted in the memorandum dared 13 Aprul 1953,

from the DCI ty she DD/A, ani the extension of this authority in subseguent

merorsnda. Spbproject 51-B has baen approvar, aad \$10,712.00

of tae over-ali Prejeet MKOLTRà fnods bave been coligated to cover taa

3125-1390-3902 qubproject's capeuses and should bo cnarged to cost concer

Concur

Concur?

APPROVED FOZ OBLJGATION OF FUNDS

Date

13 AUC
1962

Dato

Dato

Distsibatioa Orig e1 一 Addrossea

Date: 7 August 1962

[PAGE 85]
Cost Account1/25. <994-3902

[PAGE 86]
MEMORANOUM FOR: TEE COMPTROLIER

ATTENTION : Pinance Division

SUBJECT MUIRA, Subproject 51-B Addttional Authorisatlon No. 9

Under the autherity graated 1a the meoorandua dated 13 Aprll 1953 froa the DCI to che D0/A, acd the exteneion of thia auttority 1a sutsequeot memoranda, Satproject 51-Bhas. been approved, snd \$10. 712.00 of the over-all Projeet MaLT funds have beea odligated to cover he aubproject'a expecses end sbould te charged to sost ceoter 2125-1390-3902

TSD/Reaearch Sranch

APPROVED FOR ORLIOATION OF FUNOS:

CERTIFY THAT FUNDS ARE AYARABLS 143
CRUGATION REFERENCE No:
S 10 2125.1390-3902 AUTHORIZING OFFICER

:121

Date?

Diatritutioa? Originol & 2 - Adirevsee 1 - TSD/FASS 2 - TSD/RB

Date: 5 July 1961

[PAGE 87]
On July 3, 1961, one-(1)-copy of Dr. proposal for renewal of his grantfor\_the period September 1, 196l to August 3l, l962 was-sent to your\_office.

Unhappily, there were several\_errors in the-typingof-the letter of transmittal.Thetotal=funds-requested-are. not\$ 6,300.00, but are \$ 10,300.00.\_ An additional copy of the\_proposal is enclosed, at this time, since the address was also\_incomplete.

We are, currently, having a problem with new help and sincerely hope that no problem has been.caused in your\_office.

Very-truly·yours,

[PAGE 88]
Gentlemen: On July 3, 1961, one (1) copy of Dr. proposal
for renowal of his grant for the-period September l, l96l to August
31, i962 was sent to your-office.

Unhappily. there were:several errors in the typing of-the letter of transmittal. The total funds requested are not \$.6,300.00, but are \$ 10,300.00. An additional copy\_of the proposal is enclosed, at this time, since the address was also incomplete.

We are. currently. having a problem with new help\_and\_sincerely hope that no problem has been caused in your office.

[PAGE 90]
I propose, in the capacity of chief investigator, to pursue 1n the period September 1, 1961 to August 31, 1962, a program of reaearch on the synthesis and proporties of heterooyolio compounds of potential pharmacological-intorost.

[PAGE 91]
Gentlemen:

Enclosed please find one (1) copy of Dr proposal for continuation of his grant-for the period September 1, 196l to August 31, 1962. He proposos to pursue a program of research on the synthesis and properties of heterocyclic compounds of potential pharmacological interest at a. cost.of\$6,300.00.

Your review and evaluation will be very much appreciated.

Very truly yours,

Assistant-Research Administrator

Enclosure

[PAGE 92]
ATTENTION; Mr

Gentlemen:

Enclosed please find one (1) copy of Dr proposal for continuation of his grant for the period September 1, 1961 to August 31, 1962. He proposes to pursue a program of research on the synthesis and properties of heterocyclic compounds of potential pharmacological interest at à cost\_of \$6,300.00.

Your review and\_evaluation will be very much appreciated.

Very truly yours,

Assistant Research Administrator

Enclosure

Cc: Dr

July 3, 1961

[PAGE 93]
I proposa, in the capacity of chief investigator, to pursue 1n the period Septembor-1,1961-to August 31, 1962, a program-of research on the synthesis and properties of heterocyclic compounds of potential pharmacological-interest.

It is expected that-thefollowing budget will be required for this purpose:

June 26, 1961

A PROPOSAL FOR CONTINUATION OF GRANT

[PAGE 94]
Approved;

[PAGE 96]
CERTTFICATIONS

(1) It te hereby certiried that this 1s Iavoiee 12 spply ng to eud-yrojeet No. Sl-Bor MuLrsA, thst performsoce is satisfactory, What sorvicaa uro beitg arcotplished -in eccordance vith mutual agreozents, thet a detailed sçanda or the payaents and receiyts is on file in TSu/Rs, that thia. bill is just aui correet snd that payeut thereof has not yet besn sede.

Chier, TeD/Reeearun Bratch

vete: 51-B (2) It. is hereby certified thst thia invoice applies to SubPrajeet of baUlTaa vhich was doly spproved, sna that the project is beiug carrled vut in eccordance vita the seaorandua of 13 April l953 froa the Pl to the Do/A, end the axtension of this suthority in subaequent mesorenis.

\$10,712.00

For Services

Heseerch Director

SECRFT

[PAGE 97]
MEMORANDUM FORt Chef, Financo Divtaton

: TSD/Buäget Offilcer

SUDJECT

MKULTRA. Subproject 51-B, Involco No. 12, Allotment 2125-1390-3902

1. Involco No.-12 tn the amount of \$10, 712. 60 coveriag the abovo subjproject is attached.. However due to a refund of \$535. 57 from MKULTRA Subproject No. 44 (as per attachrent) payment should bo made as follows:

Caahier's check In tho amount of \$9, 764. 43 drawm on a bank.

Caaher'a check 1n the amount of \$412. 00 drawn on a bank,

Both checks should be tade payable to the

2.. The checke chould bo forwarded to Chief, TSD/Rasearch Branch, through TSD/Budgot Officer, no later than 26 July 1961.

3.  This is a final inveice. Howevor, ainco it le anticipated that adaitlonal funds will bo obllgated for this project, tho flles should not bo closed.

Chlet CHECK TSD/Reeearch Branch CF 3926443 RECHE

AttacbmonteY Invoice & Cortifications

Dorig 2 - Adressoo

Ai HIT OF OL 4 1 REULIY

14 J 1961

[PAGE 98]
GERTIFICATION

(3) N 1a horeby cortifled that under Subproject 44 at the close of yY 1960 a balaaco of \$535. 57 reproaoating unvaed funds rcmataed. Therelore it lo requoptcd that \$535.57 of Invoico Ho. 12 be cradited to Suborolect No. Sl-B as a retura of wusod Čunda FY 8-2502-10-001, MOn 336.

[PAGE 99]
MEMORANUUM POR:TSE COMOTROLLER

: Finance Division

EURJON

:MUTRA, Eubprojet -B

Additional Authorization No. 9

Vader the authority craated in the mesoranium dated 13 April 1953

froo the tCr to she do/A, aná the extension of this autrerity in sut

aequeat, gemorenie, Subproject 61-Bhae been epproved, and 6l0,7la.00.

of the over-all Projest MViaRA funds bave been obligated to cover the

. aubproject's expeases and ahould be charged to coet center-alas-1390-3902-

Chtef TSD/Reecarcb Srnnch

APPRONED FOR OBLICATION OP FUNDS:

Research Director

Diatritution: Oriéinal & 2- p&iressee

1- TSD/FASS 2-TSD/RB

[PAGE 101]
1. The purpose of Subproject 5l-B is tocontinue a program of rescarch on the synthesis and properties of organic compounds having pharmacological activities and of potential interest.

2, The scope of the rescarch program is concerned with studies directed to synthesis of heterocyclic and other organic compounds of potential pharmacological intcrest and the chemical characterization of such compounds. New\_types of heterocyclic compounds which may be useful in elucidating the action of known chemicals having central nervous system effects will bc studied.

3. The cost ofthe prógram is cstimated to be \$10, 300. 00 for a period of one year. To this sum must be added \$412. 00 representing a four per cent scrvice charge to the The total cost will not exceed \$10, 712. 00. Charges should be nade against Allotinent No. 2125-1390-3902. B

4. The has requested the to submit to them a summary accountingon an annual basis
of all monies reccived from the Also, it has been requcsted
that any unexpended funds be returned at the close of the grant year.

5. The requirements for a six months' informal accounting on the part of the principal investigator is waived.

6. Title to any permanent equipment purchased by funds granted the University shall be rctained by the University in lieu of higher overhead rates. It was mutually agreed that documcntation and accounting for travel expenses which are reimbursablc by the University shall conform with the accepted practices of that institution.

DRAFT/ 5 July 1961

MEMORANDUM FOR: THE RECORD

SUBJECT

: MKULTRA, Subprojcct 51-B

[PAGE 102]
7. Dr. agreed to comply with the requirements of the Memorandum of Agreement. mses

APPROVED FOR OBLIGATION . OF FUNDS:

Research Director

121

Attachment: Proposal

Distribution: Originaļ only

[PAGE 103]
A PROPOSAL FOR CONTINUATION OF ORANT

I propose, In tho capaoity of chief investigator, to pursue in the period Soptembor 1, 1961-to-August 31, 1962, a program of research on the aynthesis and properties of heterocyclio-compounds of potontial pharaaoologtcal intorest.

It is expeoted that the following budget will bo requtred for this purpose:

June 26, 1961

[PAGE 105]
Receipt is hereby acknowledged of the following checks; Treasurer's Check No , dated September 12, 1960 in the emount -of \$322.00, drawn on the E mayable to the B payable to the C Date:15 Sop/l 5050

RECEIPT

[PAGE 107]
MEMORANDUM FOR: CHIEF, FINANCE DIVISION

TSD/Budget Officer

MKULTRA, Subproject 51-B, Involce No. I1, Allotment 2525-1009-1902

1.. Involce No. li in the amount of \$8, 372, 00 covering the above subproject is attached. Paymeot ahould be made as follows:

Caehiar's check la the 2mount of \$8, 050. 00 drawn qu a

Cashier'e check in tho amount of \$322. 00 drawa on

Tho checks should be made payable to thep

2. The checks should be forwarded toChief, TSD/Research Braoch, through TSD/Budget Offlcer, no later than 9 September 1960.

3. This is a final involce. However, aince it is anticipated
that-additionel funds will be obligated for this project the files ahould
not be closed. m

CHECK SIN THS AMOUNT OF SSOS RECEIVE 13.SER

Chief TSD/Research Branch

Attachmente: Involce & Cortifications

Distribatloa: Original & 2. Addressee

16G I CERTIFY THAT PUNDS ARE AVAILABLE ORUGATION REN CHAGETC AIMEN 1125-10091912

1 - TSD/FASS
2 - TSD/CB

[PAGE 108]
CERTIFICATIONS

(1) It le hereby certifled that this is Invoice No. l applylng to MKULTRA Subproject 51-B, that performance is satisfactoryi that the gervicee are being accomplished in accordance with mutual agreements, that a detalled agenda of the payments and receipts is on file in TSD/RB, that the bill is just and correct and that payment thereof has not yet been made.

Chief, TSD/Research Branch

Date:\_

(2) It is hereby certified that this invoice applles to MKULTRA Subproject 51-B, which was duly approved, and that the project is being carried out in accordance with the memorandum dated 13 April 1953, from the DCI to the DD/A, and the exteasion of thls authorlty in subsequent memoranda.

3 0 AUG 1980

Research Director

Dato:\_

[PAGE 109]
CERTIFICATIONS

(1) It is hereby certified that this Is Iavoice No. ll applying to MKULTRA Subproject Sl-B, that performance ls satisfactoryi that the sarvicee ara being accompllshed in accordance with mutual agreements, that a detailed agenda of the payments and recelpte is on file in TSD/RB, that the bill ia just and correct and that payment thereof bas not yet been made.

Chief. TSD/Rosearch Branch

Date:\_

(2) It is hereby certified that thla lavolce appllee to MKULTRA Subproject 5l-B, which waa duly approved, and that the project fs belng carricd out ia accordance with the memorandum dated 13 April 1953, from the DCI to the DD/A, and the extonslon of this authority la subaequcot memoranda.

INVOICE

\$0,372.00

Research Director

[PAGE 110]
1.Date of Obligation:N/A
2. Purpose of Project: To continue a program of research on the synthesis and properties of organic
compounds having pharmacological activities and of potential interest,

3. Progresa to Date: Satiafactory

4. Expiration Date: 1 yr.

5. Project MonitorA

FROM:TSS/CD

SECRET

[PAGE 111]
: MKULTRA, Subproject 51-B

.. 1,  The purpose of Subproject 51-B is to continue a program of research on the synthesis and properties of organic compounda having pharmacological activities and of potential interest.

2. The scope of the research program is concerned with atudies directed to aynthesis of heterocyclic and other organic compounds of potential pharmacological interest and the chemical characterization of such compounds. .New types of heterocyclic compouuds which may be uaeful in elucidating the action of known chemicals having central nervous system effecté will be studied.

3. The coet of the program is estimated to be \$8, 050.00 for a period of one year. To.this sum must be added \$322.00 representing a four per cent\_service charge to the The total cost will not exceed \$8,372.00. Charges should be made against Allotment No. 1525-1009-1902.

4. The has requested the University of to submit to them a summary accountióg on an annual basis of all monies received from the Also, it has been = requested that any unexpended funds be returned at the close of the grant year.

5. The requirement for a six monthg' informal accounting on the part of the principal investigator is waived.

6. Title to any permanent equipment purcbased by funds granted the University sball be retained by the Uaiversity in lieu'of higher overhead rates.It wasmutually agreed that docurentation

DRAFT 19 Auguet 1960

MEMORANDUM FOR: THE RECORD

SUBJECT

[PAGE 112]
and accounting for travel expenses which are reimburaable by the -University shall conform with the accepted practices of that Institution.

7. Dr.agreed to comply with the requirements of the Memorandum of Agreement.

APPROVED FOR OBLIGATION OF FUNDS:

Date:8/22 60

Attachment: Proposal

Distribution: Original Only

TSD A

51-78

2

[PAGE 113]
I propose, in the capacity of chief investigator, to pursue in the period Septomber 1, 1960, to August 31, 1961, a program of research on the synthesis and properties of heterocyclic compounds of potential pharmacologicalinterest.

It is expected that the following budget will-be required for this purposet Sal ani ast

TO THE

June 8, 1960

A PROPOSAL FOR CONTINUATION OF GRANT

[PAGE 114]
page 2 June 8, 1960

[PAGE 116]
-MKULTRA, Subproject 51-B, Additloaal Authorisation No. 8

Under the authorlty granted in tho memoraadum dated 13 April 1953 from the DCI to the DD/A, and the cxtenslon of thie authority la subeequeat memoranda, Subproject S1-B bas beea approved and \$8,372. 00 of the over-all MKULTRA project funde has bean obligated to cover tho subproject exponsss. This obligatlon of fande should be charged to Allotmeat 1525-1009-1902.

Chief TSD/Research Branch

APPROVED FOR OBLIGATION OF FUNDS:

I CERTIFY THAT FUNDS ARE AVAILABLE 1960OUUGATION PEFRENCE NZCHAGE:0 O  1125-1709- 1902

Diatribatlons Orig & 2 - Addressco

1-TSD/OC TSD/FASS 2-TSD/RB

79 Auguat 1960

AUTHORIZING OFTICER

[PAGE 117]
Enolosed please find three copies of a

proposal toextend-the-current grant to

Chief Investigator and has been approved by 7

Your review and-evaluation will be very

much appreciated.

Very truly yours,

June 21, 1960

[PAGE 118]
Enclosed please find three copies of a
proposal to extend the-current grant to
August-31,1961 at a total cost of\$8,050.00. the
It is submitted by Dr.
Chief Investigator-and-has-been approved by
the University Your review-and evaluation will be very

C

much appreclated,

Very truly yours,

Enclosures-3

June 21, 1960

[PAGE 119]
I propose, in the capacity of ohief investigator, to pursue in the period September 1, 1960, to August 31, 1961, a program of resparch on the synthesis and properties of heterocycllo coapounds of potential pharmacological intarest.

It is expected that the following budget will be required for this purposer

Salariost

[PAGE 121]
TO TH3

I propose, in the capaoity of chief investigator, to pursue in the period September 1, 1960, to August 31, 1961, a progren of research on the synthesis end properties of heterooyclio compounc's of potential pharmacologioal intorest.

It ia expected that the following budget will. bo required for thie purposer

Selariest

A PROPOSAL POR CONTINUATION OF GRANT

[PAGE 122]
Inveatigator

Department of Chenustry

on Research

[PAGE 123]
Gentlemen:

The second quarterly\_payment totalling \$2,325.00 is due on the grant awarded to Dr. the Principal Investigator "on the-synthesis and properties of heterocyclic compounds of the potential pharmacological-interest.

Your promptness in taking care of this matter will be very much appreciated.A properly-addressed envelope is enclosed for your convenience.

Very truly yours,

February 9, 1960

[PAGE 124]
covering tho period September 1, 1958 to August 31, 1959, is as follows:

Total Expenditüres-September 1, 1958 \$.13,250,00 to August 31, 1959:

Attached is a report of expenditures for the period reports that you
September 1, 1955 to August 31, 1957 which
can' not find. Very truly. yours,

[PAGE 125]
September 1, 1955 to August 31, 1957

I have exanined azd approvsd the subaitted

51-87

December 14, 1959

A

TSS/Cheaical DivisionDatoy d1 Decenln19 s7

[PAGE 126]
covering the perlod September 1, 1958 to August 31, 1959, is-ae-follows:

Total Expendttarls-september l, 1958 -\$13.250.00

Attached is a report of expenditures for the period September 1, 1955 to August 31, 1957 which reports that you can not find.

Very truly yours,

Assistant Research Administrator

[PAGE 127]
September 1, 1955 to August 31, 1957

[PAGE 129]
This willacknowlege with thanks receipt of your chock dated-Sept.29, 1959-for consulting services.

[PAGE 130]
Receipt is hereby acknowledged of the following two checks:

Treasurer's Check No drawn on'the n the amount o 6,707.83, payable to The Caghier's Check drawn on in the amount of \$468. 00 payable to the

RECEIPT

[PAGE 132]
MKULTRA, Subproject 5i-B, Involce No. 10, Al1otment 0525-1009-4902

1. Invoice No. 10 In tho amount of 612, 168. 00 covering the above subproject 1s attached. However, due to refunds of \$4, 992.17 frorn other projects (as per attacbments) payment should be made as followe:

Cashier's check in the amount of \$6, 707,83, .drawn on a bank.
Cashierla check in the amount of \$468.00, drawn on a bank.

2. The checke should be forwarded to Chlef, TSS/Chemical Diviston, through TSS/Budget Officer, no later than 3 September 1959. 3. Thia fa a final Involce. Howover. since lt is anticipated that additlonal funds will be obligated for thla project the filea should not be closed.

TSS/Chemical Divlsion CHECI AMOUNT OF SEGE RECSIVEL.

21 Auguet 1959

[PAGE 133]
CERTIFICATION

(3) It is bereby certifled that the program under subprojects 49 and 59 have been satlsfactorlly completed and returned unused funds. However, eubproject 22, which is still continuing aleo refunded money. Therefore, it ia requested that the amounts as shown below on Invoice No. l0 of subproject 51-B be credited to tha subprojects as shown below.

Project

22
#49
159

Amount

\$1,703.57 585
3.224.87 1544
63.73 1912

Allotment

6-2502-10-001
6-2502-10-001
6-2502-10-001

Chief, TSS/Chemical Division

Data:

25AUG 1959

Reaearch Director

Date:

6

[PAGE 134]
RECEIPT

Receipt is hereby acknowledged of the following:

Treapurer'a Check Nod ip the amount of \$1, 200. 00 dated 17 August 1959, drawn on payable to the B

[PAGE 135]
CERTIFICATIONS

(1) It is hereby certified that this 1s Invoice No. 10 applylng to MKULTRA Subproject 5l-B, that performance is satisfactory; that the services are being accomplished in accordance with mutual agreements, that a detailed agenda of the payments and recelpts is on file in TSS/CD, that the bill le just and correct and that payment thereof has not yet been made.

Chlef. TSS/Chemical Divlsion

(2) It is hereby certified that this invoice applies to MKULTRA Sübproject 51-B, which was duly approved, and that the project is being carried out in accordance with the memorandum dated 13 April 1953, from the DCI to the DD/A, and the extension of thie authority ln subsequent memoranda.

Date:

Reaearch Director

[PAGE 136]
(3) It is hereby certifled that the program under aubprojects 49 and 59 bave been satisfactorily completed and returned unuged funds. However, subproject 22, which is atill continuing also refunded money.Therefore, it is requested that the amounte as shown below.on Invoice No. l0 of subproject 51-B be credited to the eubprojects ae ahown below.

\$1,703.57 585
3,224.87 1544
63.73 1912
6-2502-10-001
6-2502-10-001
6-2502-10-001

[PAGE 137]
Gentlemen:

Enclosed please find-two (2)copies ofthe research proposal for the continuance of the program-"on-the.synthesis and properties of heterocyclic ccmpounds of potential pharmacological interest". It ,is submitted by Dr. the principal investigator.The proposed period is September 1, 1959 to August 31, 1960 and the budget request totals \$ 9,300.00.

If this proposal is approved by your Board of Directors,  may I suggest the following payment-schedule:

September 1, 1959 \$ 2,325.00
December-1;-1959 2,325.00
March 1. 1960 2,325.00
June 1,1960 2,325.00
\$9,300.00

If this arrangement is not satisfactory, please let us know of·a more convenient one.

The Univèrsity greatly appreciates the interest in and A support of research.

Very truly yours,

July 15, 1959

Assistant Research Administrator

Enclosures;2 C CCI

[PAGE 138]
A PROPOSAL TO THE

I propose-to-performvarious-services in a consulting capaçity for the period 1 September 1959 to 31 August 1960. It is is understood that these services will comprise, among any others-which may arise, periodic visits for consultation, maintaining contacts with various parties engaged in work of mutual interest, supervision of preparative work upon request and procurement of various materials as needed. It is understood that the stipend for these services will be in the amount of \$2h00, to be paid in four-installments.

6 July 1959

[PAGE 139]
Enclosed please find two (2) copies of the research proposal for the continuance of the program "on the synthesis and properties of heterocyclic compounds of potential pharmacological interest". It is submitted by Dr. the principal investigator.The proposed period is September 1, 1959 to August 31, 1960 and the budget request totals \$ 9,300.00.

If this proposal is-approved by your Board of Directors, may I suggest the following payment schedule:

September 1, 1959 \$ 2,325.00
December 1, 1959 2,325.00
March 1, 1960 2,325.00
June 1,1960 2,325.00
\$9,300.00

If this arrangement is not satisfactory, please let us know of a more convenient one.

The University greatly appreciates the interest in and support of Dr. research.

Very truly yours,

July 15; 1959

[PAGE 140]
I propose, in the capacity of chief investigator, to pursue in the period September 1, 1959, to August 31, 1050, a program of research on the synthesis and properties of heterocyclic compounds of potential pharmacological interest.

It is expected that the following budget will be required for

Paid Carl 6707.83 Ahn11992.17 \$11,700.00

[PAGE 142]
1

[PAGE 143]
MEMORANDUM FOR: THE RECORD

SUBJECT: MKULTRA, Subproject 51-B

1. The purpose of Subproject 51-B is to continue a program of research on the synthesis and properties of organic compounds having pharmacological activities and of potential interest..

2. The scope of the research program is concerned with atudies divected to synthesis of heterocyclic and other organic compounds of potential pharmacological interest and the chemical characterization-of such compounds. New types of heterocyclic compounds which may be useful in elucidating the action of known chemicals having ceatral nervous system effects will be atudied.

3. The cost of the program ia estimated to be \$1l, 700.00 for a period of one year. To this sum must be added \$468.00 representing a four per cent service charge to ther The total coat will not exceed \$12, 168.00. Charges chould be made against Allotment No.0525-1009-4902.

4. The hae requested the University of to submit to them a summary accounting on an annual baais of all monies received from the Also, it hae been requested that any unexpended funds be returned at the close of the grant year.

5. The requirement for a eix months informal accounting on the part of the principal inveatigator is waived. .

6. Title to any permaneut equipment purchased by funds granted the University ahall be retained by the University in lieu of higheOverhead rates. It was mutually agreed that documentation

D.RAFT 7 August 1959

[PAGE 144]
dxccounting for travel expenses which are reimbureable by the Univeraity shall conform with the accepted practicee of that Institution.

7. Dr.agreed to comply with the requirements of the Memorandum of Agreement.

Chief TSS/Chemical Division

APPROVED FOR OBLIGATION : OF FUNDS:

Date81 159

Attachment: Proposal

Distribution: Original Only

TSS/Aug 59)

[PAGE 145]
A PROPOSAL FOR CONTINUATION OF GRANT

I propose, in the capacity of chief investigator, to pursue in the period September 1, 1959, to Auguat 31, 1960, a program of research on the synthesia and properties of heterocyclic compounde of potential pharmacological interest.

It is expected that the following budget willbe required for

this purpose:

51-101

July 6, 1959

[PAGE 148]
MKULTRA, Subproject 51-B, Additional Authorlzatloo No. 7

Under the authority granted in tho memorandum dated 13 Aprl 1953 from the DCI to the DD/A, and the extenslon of this authority ln subsoquent memoranda, Subproject 5l-B hae becn approved and \$12,168. 00 of the over-all MKULTRA project fands has been obllgated to cover the subproject expenoes. This obligatiou of funds sbould be charged to Allotmont 0525-1009-4902.

TSS/Chemical Divislor.

APPROVED FOR OBLIGATION OF:FUNDS

Date:

Distribution: Orig & 2 - Addresnee

1- TSS/QC 1- TSS/FASB 2-TSS/CD

[PAGE 150]
MEMORANDUM FORI CHIEP, PINANCE DIVISION

TSS/Budget Officer

MULTRA, Subproject 51-B, Invoice o. 9, A1lotment 9-2502-15-902

1. Invoice No. 9 covering the above subproject le attached. Payment should be mode ao follovs! i

Caahler's check in the amount of \$1,200.00, drawn on

The check should be made payable to tho

2. The chocks should be forvarded to Chief, TSs/Chemical Divieion, through TSs/Budget Officer, no later than Monday, 17 August 1959.

3. Thia\_ is a final invoice. Hovaver, eince-it ia anticipated that additional funds vill be obligated for this project the filas should not be closed.

Chief TS3/Chemical Division

Attachrent: Invoice & Cebtificatione

Diatribution: Orig &-2- Addreasce

CHECK AMOUNT OF \$12 2 RECEIVED.

BECEIAEJ

12518

7 Avguat 1959

[PAGE 151]
CRRTIFICATIONS

(1) It io hereby certified that this is Invoico No. 9 applying to MuLiRA Subproject 51-B, that porformance 1s satiefactoryi that the services are being eccanplished in eccordance vith mutual agreemento, that a detailed agenda of tho paymenta and receipts is on file in TSs/cD, that the bill is just and correct and that payment thereof has pot yet been mado.

Chief, TSS/Chenical Divlsion

Date:

(2) It is beroby certified that this invoice appliea .to MKULPRA Subproject 51-B, vhich waa duly approved, and that the project 1s boing carried out in accordanco with the pemorantua dated 13 April 1953, from the DCI to the DD/A, and the exteneion or this authority in subeequent pemorenda.

Datet

Rescarch Direotor

[PAGE 153]
MEMORANDUM FOR: THE RECORD

SUBJECT: Supplement to MKULTRA, Subproject 51-B

l. The purpose-of-supplementing Subproject 51-B is to provide additional funds to allow for an increase in scope of the original work. Thia inerease in scope consists of the synthesis of a number of. otherwise unobtainable chemical compounds which are needed in other projects.

2. The cost of-this supplement will not exceed \$1,200.00 and charges should be made against Allotment 9-2502-15-902. Since Subproject 51-B vas originally funded for a total of \$16,276. the new total for this subproject w11l nov amount 2 to \$17,524.

3. All of the fiscal control and security provisions contained in the original Memorandum for the Record on Subprojeçt 5l-B, dated 31 July 1957, will apply to this supplement.

APPROVED FOR OBLIGATION OF FUNDS:

Attachment: Broposal

Dietribution: Or1g only

DRAFT 22 May 1959

[PAGE 154]
16 May 1959

A PROPOSAL

I propose, in capacity of chief investigator, to undertake aprogram of preparative work on certain compounds of pharmacological-interest during the period June 1, 1959 to August. 30, 1959.

The budget required for this summer program is:

Salaries for two assistants-(half-time):-\$900.00

Supplies and Equipment-and-overhead:300.00

Total

\$1200.00

The salary for the chief investigator has been provided in the budget already approved for the period Sept. 1, 1958-to Sept. 1, 1959.

[PAGE 155]
REFERENCE: Letter of 31 March 59 from

It wiil, however, be desirable to continue fellowship for the man currently on the benzinãole problem. I can't say yet whether other fulitime graduate students will get into a research program next year which will be close enough to your specific interests to warrant fellowship aupport from the but I think it's unlikely. There will, of course, be students available who will be doing sone of the straight prep. work for pay, they can perhaps best-be-labelled as research assitants for purposes of a proposal. The university-may-prefer that this be designated fellowship also, but. this can be settled later. The budget for the scademic year, including summer of l960, will probably shape up about as follows:

Fel1ow\$1800

Research Assistents 2400

Overhead 900

Supplies & Services 1500
\$6600

I think I'll be eble\_to use this amount effectively in the projected program; it is ebout one-half the present budget.

The above dces not include summer salary;\_I"d prefer to wait and see how thinga look a year hence. It may be that it will be mutually advantegeous for me to mako this-activity my major concern next-summer as well es this, but if so, I should think we can arrange a salary later. I feel that this summer's salary together with the private reteiner of \$2hoo.adequately coapensates me for my services.

[PAGE 157]
MEMORANDUM FOR THE RECORD

SUBJECT: MULTRA, Subproject 51-B

The purpose of Subproject 51-B is to continue the work of Dr on botanical materials having a psychochemical effect, Dr has been able to ãocument the psychological effects and to identiry positively a epeciesof ceremonial mushrooms which promise to yield a completely new chemical-agent of this type. It is quite possible that the-precise-identity of-this material,/if the work can be successfully carried out, can remain ap Agency secret.

2. The scope of thia research program is outlined in detail in
the eccompenying propossl.--It should be-emphasized that item #3
therein, providing synthetic facilities, has-proven to be very
valuable in the past year.Several final prolucts and two very. useful
intermediates were securely produced at very low cost and in a few
days time by thie\_arrangcment. 1511

3. Thē cost of this program is estimated to be \$22,000 for period of one year. To this sum must be added s8co.00 representing a.four percent service charge to the Therefore, B the total cost wi11 not exceed -\$22,680.00. Charges ahould: be made againstA110tment=8-2502=10=001\~16,276.00

4. The as requested the Univeraity to submit, to them a sumary accounting of monies received from the Fund. Also, they requested the return of any unexpended funds received under a grant from the Fund on conclusion of the program.

5. Title to any permanent equipment purehased by funds granted the University shall be retained by the University in lieu of higher overhead rates.

6. It was mutually egreed-that documentoticn and accounting for travel expenses which are reimbursable by the University shall confora with the sccepted practices of that-Inetitution.

31 July 1957

[PAGE 158]
Acting Chief TSS/Chemical Division

Date . by 31–192

Dietribution:. Original Only

(31 July 1957)

[PAGE 159]
Urdor the authority erontod in tho Hesorentua dated 13 April 1953, froa tho ICI to ths DD/A and tho extoooton of this eutberity in subeequent peroreoda, Subprojoct 51-B vaa previovaly spproved. Uoder the cass eutrority rn cdditiooal sua cf 1,200.0o tes been authorized to cover the Subproject'a expenses (thoreby brlagins to a total of \$17,524.00 funds obliμated during 71 59), to to cbarced to A11oteont 5\~2502-15-202

APPRCVED POR OBIIGATIOU OP FUSIST

Dotributiont Or1g  2 - Addrvo6eo

A

[PAGE 160]
Dear A

Enclosed is a proposal for the summer prep. work. After casting around, I think that this amount is about all that I can use offectively; I-have a couple of good grad. students lined up who wili work pretty-much full-time for about two months.

I don't believe that we've ever handled the-formal proposal for these sunmer grants the same way-twice, but I think the enclosed document should fill your requirements. As far as the University is concerned, this summer thing can simply be handled with a check\_for the\_total\_amount payable to the University and-sent to me.

Asuggested to me when we talked that I get this in promptly so you can handle it from odd funds still available. I think the amount is about-what you andI had agreed upon earlier. I plan to clean up some odds "and ends, perhaps doing something on the 4-oxygenatedindole problem, and to get going again .on the bons(cd) indole work. I'm hopeful that theboys will get underway in earnest on the indole, I sent them3.5 kg. of\_starting material-which I had luckily laid in for just such a contingency.Theydidn't even know where to buy it.. I'm going to-keep after them closely.

You might give me a call to confirm this sumner grant. I'd appreciate knowing what will be done to get the retainer question straightened out, too. I will get proposals for the coming year (Sept. 1959 to Aug. 1960) written up soon, and perhaps we can go over them the next time we get together.

Sorry to have missed you last time.

Best rogards,

DEPARTMENT OF CHEMISTRY

15 May 1959

[PAGE 161]
Receipt is hereby acknowledged of the following:

Cashier's Check Nos in the amount or t626.00. dated E EB
September 10, 1958, dravi on
payable to

[PAGE 162]
Ye aro plessed to inform you that the Board of Directora of the have approved a reaearch grant for Dr. f the Department of Chemistry in the amount of \$13, 250 for year beginning 1 September 1958.

2. We regard the present grant as a continuatlon of our previous agreementa with Dr and the Univeraity and the funds will be transmitted in the eame manner as in the casa of previous grants. If it meete wiyour approval we will aesume that the prevlous agreements will exttnd to the coming vear.

[PAGE 163]
I have examined and approvod the subottted Very truly yours, expenditures.

Acting Chief TSS/Chemical Division

Assistant Research Administrator

[PAGE 164]
A report of exponditures for Dr projoct is as

The period covered is September l, 1957 to August 31,

Very truly yours;

Assistent Research Administrator

[PAGE 165]
I enclose a copy of a summary report which I received at the same time as the report.which-you got last spring. This is not a o copy of the same rèport, but I think it may have tho same informa-- tion.

I send this for.what good it:will do you which I'm afraid isn't much; it isn't signed nor,official in any way. I called
as soon as I finishod talking with you,and she said she wouldh be sonding anything lator until the middle of. next month, wheh the final report for the year will be ready. She also had no copy of this last onc available. Ithon explained that you had to have this sronto, and to make a copy of thetoldone.She agreed to do this, and I think she plans to bring-it-up-to-date-as of July or so; this revision will apparently take-no more time, She said that this wouldn't be ready before tomorrow aftornoon or Monday, howevor. I have no way to brace hor up on this,nor-no good way-of expediting Meanwhile-porhaps the onclosed willi be of help.

I trust you got the address, etc.

Bets,regards,

[PAGE 166]
1785

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id

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79

2075
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92.03

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320.84

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es

SttrPnt-

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Saes

[PAGE 168]
(1) It is bereby certiried that this is Invoice No. B applying to Suboroiect Sl-B of MULTRA, that perfononce 1s satiefeotory, that sorvices are being accomplished in accordance vith mutual agreements, that a detailed agenda of the poymenta end receipts is on file in asg/cp. that this bill is fuat and correct and that payment thereof bas not yet been made.

(2) It ie boraby certified that this invoice applies to Subproject 51-B of KxutTRA which vas duly opproved, and that the projoct is being carried out in accordance with the mecorandua dated 13 April l953 from the DCI to the DD/A, and the extonsion of this authority in subsequent metoranda.

[PAGE 170]
13 Apel1 3953 Proa Uha DCI to the m/A, end the extension of this euthoaity in suteequent manorends, Sulpoject 51-B bea boen maovod end 16,876,00 cf the over-al1 Project Ma furde has bosn cbllgatet to cover tho subproject's exonses and abould bo charged to A1lotmmnt 9-2502-15-902.

APPACNED FOR CELLOATION OF TUUDG1

I CERTIFY THAT FUNDS ASE AVARABLE OUGATIÓN DCE No392 SHARGS10ALLON9.3503-15=9082 AUTHORIZING OFFICER

Dietributions Orig 4 2= Adásecs0s 1.-T8s/0c 1/1- T93/PASB 1 TSS/SRB 2 -T9S/CD

[PAGE 171]
TOP SEGRET

[PAGE 172]
MEMORANDUM FOR:THE RECORD SUBJECT ; MKULTRA, SubproJect 51-B

1. The purpose of Subproject 51-B is to continue the work of Dr. on botaniçal materials having a psychochemical effect. has been able to document\_the psychological effects and to identify positively a species of ceremonial mushrooms which promise to yield a completely new chemical agent of tbis type. It is quite possible that tho preciso identity of this material\_can be\_deterrined during the coming year.

2. The scope of this research\_program is outlined -in detail in the accompanying-proposal. It should be emphasized that Item No. 3:therein, providing synthetic facilities, hes proven to be very\_ valuable in the past year. Several-final products and two very useful interwediates were securely produced at very low cost and in a few days time by this arrengement.

3. The cost of this program is estimated to be \$15,650 for a period of one year. To this sum must be added \$626.00 representing a four percent service charge to the Therefore, the-total cost wil1l-not exceed \$16,276.00. Charges shouldbe made ageinst A11otmeat 9-2502-15-902.

18 August 1958

[PAGE 173]
4. The hes requested the University to

submit to them a summary\_accounting of-monies received from the

Also, they requested the return of any unexpended funds

received under a grant fron the on cooclusion of the program.

5. Title to any peruanent-cquipment purchased by funds

granted the University shall be retained by the University in-lieu

of higher overheed rates.

6. It was mutually agrced that documentation and accounting

for travel. expenses which are reimbursable by the University-shall

conform with the accepted-practices of that Institution.

agreed to comply with the requirements of-the

Memorandum of Agreement.

Chief TSS/Chemical Division

A.

APPROVED FOR OBLIGATION OF FUNDS:

Date:A19-1058

Attachment: Proposel

Disbribution: Original Only

(18 August 1958)

[PAGE 174]
I propose, in the capacity of chief investigator, to pursue in the period Sept. 1, 1958 to-Aug. 31, 1959, a program of research comprising the following activities:

1. Chemical investigations of-the pharmacologically active constituents of various plants and fungi.

2. Investigations on the chemistry of new heterocyclic compounds of potential pharmacological interest.

3. Synthesis of-miscellaneous compounds of pharmacological interest.

It is expected that the following budget will be required for the program outlined above:

Proposal for Continuation of Grant

11 August 1958

[PAGE 175]
Receipt is hereby acknowledged of the following:

Dato: 7-11-58 19.e58