[PAGE 1]
Nedieaal lutlese of Meaà He Addiction Recareà Cester
U.S. Pabtic Headh Serrics Hospital Leziagtoa, Kratacky

12 February 1959

I anencinsing herewith thermofax copies of papers hy Dr. K. Kumagai and his associates. Dr. Kumagai just visited us and kindly allowed us to reproduce these papers.

You probably have the older papers available to you, but one of those reproduced -- "Neuropharmacological Studies on a New Series of Ergot Alkalaids: Eiymoclavine as a Potent Analeptic on Peserpine-Sedation" -- has not yet been published. Data in the paper are somewhat confusing and appear to contradictsome of the statements made. This however may be due to the authors difficulty with English.

I asked Dr. Kumagai to try to make available some of the ELY and its dehydrogenated congener DAG when he returned'to Japan. He indicated that he could arrange this through the pharmaceutical company.

It was pleasant to see you in Washington and I am laoking forward to the receipt of additional material for testing.

Yours very sincerely,

Harris Isbell, M. D. Director

HI:lw

Enclosures

C-588

123

DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE

PUBLIC HEALTH SERVICE