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Technical" Branch, SHS, I&SO Request, for Hedical Office Investigation Into New Compound

1. During the writer's recent trip to the writer met and engaged in a lencthy discussion aith. a rankine staff member of the in the BJ3 Department of Anesthesiology. who is regarded as exceptionally able by his associates, informed the writer that in the recent past he has handled, experinentally, a new compound for the

2. stated that the was working onC3 experimental compounds to either displace or improve on the already wellknown barbiturates. He stated that, they had sent him a compound and re-C quested that he try this during operative procedure stated he gave it to a very conservative member of the 8 faculty during a minor throat operation and that the drug worked successfuily for operative purposes. He stated, however, that during the recovery period, this compound produced very uninhibited reactions on the part of the subject. He stated that for forty-eight hours after the use of the drug. this conservative memher of the faculty had talked at great length and in a highly derogatory manner about the faculty, about the administration of the school, about certain professional secrets at the had cursed, had wandered B about the corridors and had strong tendencies to attack the nurses at the

3. The writer askee if he had tried the compound on C other patients and he stated that, he hád dore this, thinking perhaps an eccentricity existed in the above case, but the compound reacted the sams on the other two cases and,:thereafter hadabandoned all use of this chemical.

h. Thereafter, the writer, without attempting to create anyunusual interest, requested the name of the chemical from and stated that it was known as SPIRO-OXY-BAREITURATE.

A few days ago, the writer had an informal ccnference with eof the Medical Staff concerning other matters and, at this conference, the writer told the above story to hnd rave A him the name of the compound in question and made an informal roquiest at that time thatr: have this compound checked to determine whether or not it had ARTICHOKF. value.

Office MemOranum : UNITED STATE-GOVERNMENT

DATE: 7 January 1953

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6. It is suggested that you turn over a copy of this memorandum with your approval to the Chief of the liedical Staff merely for the.. purpose of confirming in writing the informal request made of as-mentioned above.