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INSTRUCTIONs:Cr dation scn anenc commeat numeaed to carrond ae rupyn aheo noud ntal cnes ar ce c heioe urther routing This Routing and Fecert Shee souia on un ac y

Transmitted herewith are the questions for the people referred to in our telephone conversation today.

A/B21111

UNCLASSIFIED

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mat animal tests or observations would bo significant ii a study of pryehogonie mnteriala? To wias extant nnd in uhat xonner do you feol animal data yould corrolate with alinisal obscrvntions on hunans?

What spocial characteristics of moscnline, Rauwolfia, and iSD
respectively, lead you to fcol they my be of value uhen usod in
conbinationa? In what way would you expoct tho characteriabics
of one to coaplemont, antagoniso, or accontuato the charactoristics
of anothor, and how would this be of valuo? -

In that vay would you oxpest a combination of chlorprosmsine and corpacil to be murorior to one or tho otior alone?

+A

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In what spocifie vays and to wlia cctent do you feel

"muggegtion" ny influencn the effects observol and reported in. Individuals vho have taken materials such as LSO, moscaline, etc? In othcr voris, hov my the suoject's erpoctatlonn, tho invegtigator's exprensed or Lnplied expectations, atsitude, ete., influanco tho obsorved effects of such matorials? If such factors can bd expected to influence tho obsorved effecta, in wirat way can a person take this into considoration in tho evnluation of investigations with LSD, msacalina, ete?

To what extent do you feal tho abova fsctors mny iniluicre? the rosult of clinical evaluations of druga which are noe ordinarily considored pagelogenie, and how moy theso erfects te ovalunted?

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The statement is orten sade trat fE stulies wiih oichcr surfaen or deop electrodos vould be vory vaoful in testing poychogenie Arugs. Constdering tho prerent karouionge of the art, do you feol Lint it vonld bo possiblo:

pattoru of cortical (or sub-cortical) elcctrical activity in hunn beings referable to a given doce of payehogeaic material when that doso is in the cormal effoclivo done range?

(b) To mlate such pattorns of elcctrinal activity to obeorvable alterations in affeet or behavior such as the productien of suphoria, deporson-liantion, subtlc changes in ths lovol of neptration, cte?

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It often appenrs that a known conbimtion of envlroncantal factors and/or the adninistration of certain mtorials produco in hurun boings on altoration of stote cich thai. tho materinls or environmontal aituntions cro charaoterlsnd by tho observer as "psynhogenic". The problen which inevicably arisog from this observation.ls that of dofining the linits alit of the porsonality alteration in taras of behavior in such a way as to mko possible an nscossnent of the reality and usafuinens of tho observed sffocts in otborise "normal" subjoets.

In such a situation as that outiined abovo can you susost tests which wouid evaluate objectively changos In such factcrs as strongth of motivation, capasity for criticsl judgrent, ability to relate to othern, rezoty, versatility in role playirsi erceptivity to chngos in imtediate eavironnent, changos in level of aspiration or thair corrolates producod in an individual by such treatmont?