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I have worked the dose of C-5 up to 100 mg./70 kg. of body weight without obtaining any appreciable sub jective mental effects, or any objective changes in behavior. Cardiovascular effects of the degree seen with C-9 also have not been apparent. The material has been given in alcoholic solution by mouth.

It appears to me that this is a relatively inert drug." Do you wish me to take the dose any higher, or to discontinue study cf it?

I have to be in Washington from March 27th through April 3rd and will have some free time on Monday, March 3ist and on Tuesday April lst. i could come down for a visit if you so desire. .I will give you a call while in Washington.

Sincerely yours, Nerrei deel

Harris Isbell, M. D. Director

HI:tkh:lw

C-647

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Hnirant lnticata of Mcatal Hesich Addietion Resach Caater U.S. Pulie Heanth Serria Hospitu Leriagton, Kestecky

151

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PUBLIC HEALTH SERVICE

DEPARTMENT OF HEALTH. EDUCATION, AND WELFARE !R

17 March·1958

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