[PAGE 1]
4
tece ct Griceal aloteené Cerard 2
15 0k. 59 1sge.. 16 721,320.00

Parica Azeané er Covaxsd ¬t 15 7 1909-976 800.v0 3 60 - 61 5 800.ci 24 gam6130.g61108190324960.00 2

ACRA 19 w20 6.2 3 20. d0. 4 \$20,800.10 20 c0 60 00 00 Outest 2496222 (wck5 2.6

[PAGE 2]
2000/00

Chis is continuation of MKULTRA sub-2cojaat #91.

2, Froçose af Projeatt

Advanced animal screening and

preclinical pharmacological

2. Frojoet Naltors.

[PAGE 3]
o , bot 91

Date Initiated: 15 January 1959

Pete Expires: 1 Pobruery 1962

Punds-current year; \$48,000

Purposet To provide an advanced animal screening end pre-clinical pharmscological testing of toxics ani druge affecting buman bebavior with special reforence to drug efrecte and wolecular structure relationshipe and avoidance of undesirable effects.

Statust A continuing progran of ad hoc screening and testing utilizing protocole provided by and closely monitored by TSD.

91.3

[PAGE 4]
: MULTRA Subprojects 70, 91, 9h and 135

Since the completion of the audit of Project MULTRA for the period 1-August 1960 through -31 January 1963, accountings have been received fro in the amount of \$93,677.50. This amount B 1s part of the s15o,117.93 balanco to-be accounted for by grantees at the end of the audit period.

Subproject 70 incurred direct-costs of \$2,518.34 and \$27,872.16 transferred from Subproject 9h, for. a totat of-\$30,300.50. Subproject gh incurred expenses of \$71,32h.87, but trensferrod\$4,165.71 to Subproject 91 and \$27.872:16-to Subprojoct 70. leaving a-nəet cost of \$39,287.00. It was decided to divert the funds-for Subprojcct 135 to-Subproject 91, therefore these costs vere included in the-accounting fron Subproject 91..

Inasmucl. as: 1) all four.of the subprojects had the same basic re
search. goal in mind, 2) the.great length \_of\_time that has elezed since
the grants were made, and3) the difficulty in gotting accountings of
any sort from the grantee, it-is-recommended that we facilitate this mat
ter by accounting for the balances:az:showm in n

Tho abovo has been concurred in by andof the Audit Staff.

91-4

11 June 1964

MEMORANDUM FCR : THE RECORD

[PAGE 6]
Per conversation wy

O.K. to tuen in acctge on Sub Projects 70, 94 and 135 as done. Irasmuch as it io so long after, the fact, and the difficulty in getting acctgs of any sort, we can use the acctgs as rer'd. Cross- reference the pwitching in all three, of Audit Staff are auare of there problems o concers. If possible lave pomeone in authority sign memo for rocord efplaining reasons for doing seich.

91-y

[PAGE 7]
A Conerstn / 24 1554

retains all theibrakst records of difunct 8 Ne has submitted preliminasey acctgs for Sub no-4, 9\$-5 9f-. once he is able to thoroly analyze aee the books t ricords he wiel teen-in complete, finalizedl accounitings for these. projecte these theee projects ale hadl the same gral, which was the drug. ihat's why they feet justifiel in shiftig the money around. feels it probably would al have been hetter if only oney rather than four (13s projects was writtew t aucharied. , aulit Stift, are dealing dircotly c/ are auare of oue problims in getteng satisfactory acctgs for these progects, Audit feel "giod" for these acitgs which they are alro waiting for. thirfore wvitk .the abone knoinkdge, werle hald thise "prelim" acotgnt has prepard the "finabs," which sheued he rerdy in the nery miar fetuze

[PAGE 8]
I certify that services or materials have beea satisfactorily received and the expenditures were incurred on official huainess.

[PAGE 9]
91.-6 135

[PAGE 11]
91.8 Gentlemeni

Herewith ie a statement of the funds expended in behalf of the project on pharmacological screening and testing.We truat that it will be adequate for your purposes.

[PAGE 12]
February 1, 1961 To January 31, 1962

\$48,000.00

Inv 3 2ym

Costs - Feb. 1, 1961 To-Jan, 31, 1962

Salaries
Payroll Taxes and-Insurance
Employeest Hospitalization and Benefits Ins. Leboratory Supplies and Expense
Travel
Qther Costs

Allocation of G and A Expense

\$ 23,489.27
1,027.36
416.19
3,999.17
1,506.12
3,847.50
\$34,285.71
13,714.29

Cs

I have eznined cubaitted expenditure

Dete: /0/3

TSS/Cheaical Divis

[PAGE 13]
3. is pev sf tke saceviy dsfcuties lovalrc4 1\~ be actasl retera td hade from the ctai asá slso áisk4 avaiksr aibércjact (f) vas bars servedby tae sams rvo, ard furtkerote, riace aabprc|e<t 031 wax capab|6 01 pr0r2c|=8 19k 86vvice4 02 1ka96 chomcécal aseata pt literést and d rine the samie lipcal veat, t caa beee cacia41 te dvart vha vork ialraáed 19r vebyroject 8135 1o 1he facl111ee 1 va1project 491. ko 628v10<a3<k3k2a ic 1vadieg or v47iacv 1e 5acal v48216.te5cer1e< 16 151a mabe7.

CONCUR

Or1gisx1 0221

[PAGE 14]
MEMORANDUM FOR: THE RECORD

SUBJECT

: Correction to Project MKULTRA, Subproject 91, Authorization No. 5, dated 27 June 1961.

1. The referenced subproject was extended in June\_for only six months when the intention was to extend for one year in time, but to finance the first six months only at the time of renewal.

2. In order to clear up this matter, Subproject 91 is hereby extended in time only for six months beginning 1 February 1962.

91-10

10 November 1961

… -

[PAGE 15]
No.116

Cost Account 2125.1390-3912

Object Class

[PAGE 16]
MOMORARDUM FORI COIGTBCLLZR

ATTESTION 1 pinance Divieiou

I WLTRA, Subproject21 Authorizatioa Bo. 2

Voiar the authority grented in the negorandua dated 13 April 1953, froa the pCI to the DO/A end tha extension of this authority io autsequent meooranda, Subproject 91 vaa previously epprovod. Undor the saze authority an additionel saa of 24,960.00 has beon suthorired to covar the subprojects expenses, to ta charged ageinat coat centor No.2125-1320-3002.

Chief TSo/neszerch Brench

APPROVED POR GBLIGATIOH OF FUNDST

Reseeroh Da.tel

I CERTIFY TRAT RUNDS ASE AVAILASLE QAUGADONROSCE. O 10 2125-13903802

Distributiont Original & 2- Addressce - TSD/FASS 2-TSD/RB

TSD/RB27 Jume 1961

91-12.

DATS 27 June 1961

n.

[PAGE 17]
MEMORANDUM FOR: CHIEF,"FINANCE DIVISION

YIA

: TSD/Budgst Officor

SUBJECT

: MKULTRA, Sabproject 91, Invoice f5 Allotment 2125-1390-3902

1. Involce #5 covering the above subproject ie attached. Payment should be made as followe:

Caghinr'g check in the amqunt of \$24, 000. 00 payable drawn on B to

Cashler's check in the amount of \$960. 00 payable to B drawn on

2. Please fcrward tha checke to Chief, TSD/Research Branch through TSD/Budget Officer by 21 August 1961.

3. This lé a final involce. However, eince it is anticipated that additional funde will bo obligated for this projoct, the files ahould not be closed. I

91-13

4 Aagiat 1961

[PAGE 18]
AUTHCRZING OFEICER

MEMORANDUM FOR: CHIEF, FINANCE DIVISION

: TSD/Budget Offcer

SUBJECT

: MKULTRA, Subproject 91, Invoice f5 Al1otment 2125-1390-3902

1. Involce. 95 covering the above subprojoct is attachod. Payment ahould be made as followe:

Casbler'e chock 1a the anount of \$24, 000. 00 payable B drawn on

Cashler'a chpck ln tho amount of \$960, 00 payable to drawn o0

2. Please forward the checke to Chief, TSD/Reeoarch Branch through TSD/Budget Offcer by 21 August 1961.

3. This ls a firal invoice. However, since it is anticipated that addltiooal funds will be obligated fer this projoct, tho filed abould not be closed.

Chlef

TSD/Roeearch Branch

3AUG

Attachmoata: Invoice & Certifications

1 CERTIFY THAT FLINDS ARS AYAILABLEI DRUGATION REFTENCE NO. 1025.60-390

Diatributioa!

Orig & 2- Addressce r- TSD/FASS 2 = TSD/RB

TSD/RB(4 August 1961)

91-13

4 August 1961

[PAGE 19]
We are pleased to be able to tranamit to you the followiag funde:

Treasurer's Check No, 184885, dated August 15, 1961, drawn on the for \$24, 000.00.

Treagurer's Check Wo 268751, dated Augupt 15, 196), dre Eon th for \$960.00.

Thtse fuda represent a contribution for the use of your directors in carrying out the very worthwhilo reeearch goals of your obligatione.

Yours truly,

Attachmente (2)

91-14

17 August 1961

[PAGE 20]
CERTIFICATIONS

(1)It is kereby certifled that this is invoice5applying te Sub-project No. 91ef MKULTRA, that performance is satisfactery. that serviccs are buing accomplished in accerdance with mutual agreements, that a detailed agenda cf the yayments-and receipts is en file in TSD/RB, that this bil is just and cerrect and that payment therect bas aot yet been made.

Chief, TSD/Research Branch XLSM:T

Dates

(2) It is hereby certifed that this invcice applies to Subproject, \~01 of MKULTRA which was duly approved, and that the project is beinġ carried out in accordancs with the memorandum of 13 April 1953 frem the DCI to the DD/A, and the extensioa of this authority in subsequent memoranda,

91-14

For Services

INVOICE

\$24,960,00

Research Directer

[PAGE 22]
SUBJECT

: Continuation of Project MKULTRA, Subproject 91 Authorization #5

l. The purpose of this subproject is to provide funda to coatinue the research program which furnisbes advanced animel screening and preclinical pharmacological testing required by the, program on the development of new psychochemicals. The program is, providing fundamental inrormation bearing on the problem of structure activity relationships among these coapounds.

2. The research-group conducting the investigations are exerting their best efforts to provide the data requirementa, imposed on them. The experimental work being carried out under this project is oriented and programmed to meet our planned research and development needa. In order to bring th progrem into alignment with contemplated researches and possible modifications that may be dictated by anticipated results from the current research, thie progrem will be extended for a six month period. e y

3. The cost of this program for a period of six monthe beginning 1 August.1961 is estimated to be \$24,000.00. To this sua must be added \$960.00 representing a four per cent service charge to who will act as cut out, so that the total coet of the project will not exceed \$24,960.00. Charges should be made against A11otaient No, 2125-1390-3902.

91-15

27 June 1961

MEMORANDUM FOR: THE RECORD

[PAGE 23]
5. It ie not anticipated that any permanent equipment will be required for this program.

6. It has been agreed that documentation and accounting for travel expenses which are reimbursable ehall conform to the accepted practices of the crganization conducting the\_reeearch.

7. The requirement for a semi-annual informal accounting on the pert of the principal investigator has been vaived.

8. All personnel connected with the planning and monitoring of this program possesses Agency TOP SECRET approval. The project vill be

unclassified after 1t leavee thel

APPROVED POR OBLIGATION OF FUNDS:

Date:3AG

Attachmente: Budget and propoeal
Diatribution: Original only.

91-15

[PAGE 24]
It is proposed to continue certain biological tests of a

pharmacological nature as directed by the Sponsor of this. project

on chenical materials and extracts to be furnisbed by the Sponsor.

These tests involve small animal studies and/or clinical work in

certain cases as -indicated in each particular instance..\_The sponsor

vill have full coatrol of themethods and procedures to be folloved

in the work and it is understood that these will vary during the

course or the project depending upoa research findtngs in other

facilities working in this same general-blological, progrem.

In aldition, as time end funds aliow, pilot experlments will be

perforued utilizing various knovn substances having effecta on the

central nérvous-syetea in an effort to refine aná improve the present

capability of detecting and characterizing such activity in small

animals. Attention vill elso be given to the problem of extrapolation

of results betveen varicue species of animals.

It is expected that the attached budget vill be required to carry

out the program outlined above for a perioå of six monthe:

91-15

PROPOSAL

91-7

[PAGE 25]
BUDGET

91-15

[PAGE 26]
Gentlement

We are pleased to be able to transmit to you the folloving fundet

Treasurer's Check No. 18oc03 datei 10 February,1961, drevn or\$960.00.
E or Cashier'a Check No, 2 02188, dated 10 February 1961, drava for
E on \$24.000.00.

These funds represent a contribution for the use of your directors in carrying-out the very vorthwhile reaeerch goala of your obligations.

Youre truly,

Enclosures (2)

91-16

15 February 1961

[PAGE 27]
Cost Account 1125. 1590- 2212

Object Class

91.17

[PAGE 28]
DAS: 86 1ow17 1961

MERORANCON FCR: COMPTROLLER

AITCETTON

SUPJ0OT

Firence Diviston MaEERA, Suoprojeot,Anthorizatien To.

Uunãer tho authority grentsd in the eacoraniar datol 13 April l953, froa the Do7 to the DD/à end the extaasion of this Gutharity in subseçuent mesoranda, Subprojeet 9 Ta: preztcurly exprovol. Uhãer the anse euthorlty an cdaitionsl muo ofah,96o,0o has. beco authorized to cover tha avbyrojaets epensas, to be chargsd eqainat ccst center Mo. 1129-1390-3902.

A To/Research Franch

APEROVEO FCR ODLIGATICN CR PURDS:

AN 15

Dote:

Dlgtributico; Orig. 2.- Asfeaoce -TSD/FASS 2 - TSD/RB

91-18

1413

[PAGE 29]
2 Pebruary 1961

MEMORANDUM FOR: CHIEP, PLAANCE DIVISICN

1 TSD/bulget Officer

SUBJDCT

NULTA, Subproject 91, Invoice h A110taent 1125-1390-3902

1. Invoice f4 coraring the above subproject is attacbed. Payzent should be made as followa:

enoynt, of 324,000.00 payable Ceshier trawn on

of \$960.00 payeble to Arawn coery

2. Please forward the chacks to Chier, TSD/Rasearch Branch through Ten/mudget Orricer by 15 February 1961,

3. This is a final invoice. Hovever, since it is anticipeted that additional funis will be obligated for thie project, the files should not be closed.

95-19

[PAGE 30]
2 Redruery 1961

91=19

ETCES

[PAGE 32]
SUBJECT: Project MKULTRA, Subproject 91

1. The purpose of this subproject is to provide funds to continue the research program which furnishes advanced animal screening and preclinical pharmacological-testing required by the program on the development of new psychochemicals..The program 1s providing fundamental information bearing on the problem ofetructure activity relationships among these compounds.

ing their best efforts to provide the data requirements imposed on them. The experimentat work being carried out under this project is oriented and programed to meet our planncd research and development needs, In order to bring the program into-alignment with contemplateć rescarches and possible modifications that way be dictated by anticipated results from the current research, this program will be extended for a six month period,

3. The coat of this progrem for a period of six months beginning 1 February 1961 is estimated to be \$24,000.00. To this sum must be added \$960.00 representing a four per cent sorvice charge to the Lwho will act as cut out, so that the total cost of the project will not exceed·\$24,960.00. . Charges should be made against Allotment No.1125=1390-3902.

DRAFT

97.20

25 January 1961

MEMORANDUM FOR THE RECORD

[PAGE 33]
funds remaining at the end of the grant period.

5. It is not anticipated that any permanent equipment will be

required for this program.

6. It has been agreed that documentation and accounting for

travel expenses which are reimburseable shall ccnforn to the accepted practices of the organization conducting the research.

7. The requirement for a semi-annual informal accounting on the part of the principal-investigator has been waived.

8. All personnel-connected with the planning and monitoring of

be unclassified-after it leaves

APPROVED FOR OBLIGATION OF FUNDS:

Date.

Attachrents: Bulget and proposal

Distritution: Original only.

9120

[PAGE 34]
It is proposed to continue certain biological tests of a

pharmacological nature\_as directed by the Sponsor of this project

on chemical materials and extracts to be furnished by the Sponsor.

These tests involve-small animal\_studies and/or clinical work in

certain cases as indicated in each particular instance.\_\_The\_sponsor

will have full control of\_the methods end procedures-to be folloved

in the work and it is understood that these will.vary during the

course of the project depending upon research findinge in-other

facilities working in-thissame general biological program.

In addition, as time and funds allow, pilot experiments will be

performed utilizing-various-known substances having effects on the

central nervous aystem in an effort to refine and improve the present

capability of detecting and haracterizing such activity in small

animals. Attention will also be given-to the problem of extrapolation

of results between various-species of animals.

It is expected that the attached budget will be required to carry

out the program outlined above for\_a period of six months.

PROPOSAL

91-20

[PAGE 35]
BUDGET

B

[PAGE 36]
Expenditures

Salaries and wages\$4605.50

Materials and Suppliea3943.00

Rent and Ut111tiea8349.22

Travel 573.30

Services 789.64

Social Sec. Ins, etc.587.96

Overhead -1151.38
20,000.00

91-21 91

[PAGE 37]
Gentlemen:

We are pleased to be able to transmit to you the following funds:

Treasurer'a Check No. 248053 drawn on , for \$1,800.00

Treasuzor!a Chock No, 172861 drawa on for \$45, 000.00

There funds represent a contribution for the use of your directors in\_carrying out the very worthwhile rosearch goale of your organization.

Youro truly,

Eaclosures (2)

91-22

15 March 1960

[PAGE 38]
Cost Account 1225: 109:4962

Object Class .

91-23

[PAGE 39]
ll February 1960

MEMORANDUM FOR: COMPTROLLER

ATTENTION: FINANCE DIVISION

SUBJECT

1 MKULTRA. Subproject 91, Additional Authorisation No. 3

Vader the suthority zranted in the memeranduna dated

13 April 1953 from the DCI to the DD/A, and the extenslon of

thle autherity ls aubsequcnt mencoranda. Subproject 91 bas

beea approved and \$46,800.00 of tha over-all M4KULTRA projact

fuads has been obligated to cover the subproject oxpeneds. Thie

obligatloa ef funds abould be charged to Allotmant 0525-1009-4902.

Chiel Chtel

TSS/Chemlcal Divieioa

APPRÓVED FOR OBLIGATION OF FUNDS:

UNRY INAT SQNOS ANE AVALARS DEGNON IETPIO R 1225

Research Ciyector

7FEC

Daie:

Distributica: Orig à 2 . Addresseo

91-74.

TSS/CD/(11Feb 60)

[PAGE 40]
SUBJECT:

I hereby acknowledge receipt of the following:

1 FORM NO. 752 REPLACES FORM 36-68 1 AUG \$5 WHICH MAY E USED

MEMORANDUM RECEIPT

DATE

T0:

FROM:

SUBJECT:

I hereby acknowledge receipt of the following:

FORN NO752 REPLACES FORM 36-66 WHICH MAY BE USED.

TO:

MEMORANDUM RECEIPT

91.25

FROM:

[PAGE 41]
MEMORANDUM FOR: CHIEFFFINANCE DIVISION

VUA

: TSD/Budget Olfilcer

SUBJECT

: MKULTRA, Subproject 91, Invoice #3 Allotment 0525-1009-4902

1. Involce f3 covoring the above aubnroject ls attached. Payment should be made as followe: 1

chsch in the amaunt of 31, 800.00 payable B drawa

Caaazia chock Je the amount of \$45. 000.00 payable adrawn cn

2. Please torward the checks to Chief, TSD/Chemical Branch through TSD/Budget Officer by 15 March 1960.

3. Thie is a fnal iovoice. However, since it is anticipated that additional funds will be obligated for thla project, the files ghould act be cloeed.

Attachmente: Invoice k Certificetions

Dietributiop: Orig 2- Addrassee

it H3.8 3 Pb1,E0

VECEIAED

112

91-26

1 March 1960

[PAGE 42]
CERTIFICATIONS

(1) It is horeby cortified that thls is Iavolce #3 applying to Subprojact 91 of MKULTRA, that performance is eatiefactory, that services are being accompllehed in accordance wlth mutuel agreernents, that a detailed sgenda of the payments and recelpte is filed in TSD/CB, that thie bill is juat and correct and that payment thereof bas not yet been made.

Chief, TSD/Chemical Branch

Date:

(2) It la horeby cortifled that thie lnvolco applles to Subproject 91 under MKULTRA which was duly approved and that tho project is belag carrled out in accordance with the memorandum dated 13 April 1933 from the DCI to the DD/A, and the extenslon of thie authority in subaequent memoranda.

Date:

9126

For Services

INVOICE

\$46,800.00

Research Director

[PAGE 44]
: Project MKULTPA, Subproject 91

1. The purpose of this subproject is to provide funds to continue the research program which furnishes advanced animal screening and preclinical pharmacological testing required by the program on the development of new psychochemicals.\_The program is providing fundameutal information bearing or the problein of structure activity relatioaships among these compounds.

2. The state of knowledge in areas of influencing human behavior has been steadily improving and the experimental work being carried out under this project is meetiog our programmed needs.: The sponsor has obtained and assigned highly competent technical personnel and is exerting his best efforts to provide the data requirements imposed on him.

3. Thə cost of this program for a period of one year beginning 1 February 1960 is estimated to be \$45, 000,00. To this sum must be added \$1, 800.00 representing a four per cent service charge to who will act as cut out, sp that the total cost of the project will not exceed \$46,800.00. Charges should be made against Allotment No. 0525-1009-4902.

submit to them a summary accounting of funds receivedg

9127

DRAFT 11 February 1960

MEMORANDUM FOR: THE RECORD

SUBJECT

[PAGE 45]
from  and that they return any unused funds remaining at

the end of the grant period.

5. It is not anticipated that any permanent equipment will be required

for this program.

6. It has been agreed that documentation and accounting for travel

-expenses which are reimbursable\_shall conform to the accepted practices

of the organization conducting the research:

7. The requirement-for-a semi-annual infornal accounting on the

part of the principal investigator has been waived.

8. All personnel\_connected with the planning and monitoring of this

program possess Agency TOP SECRET approval.The project will be unclassified after it leaves th

TSS/Chemical Division

APPROVED FOR OBLIGATION OF FUNDS:

APPROVED:

Chief TSS/Chemical Division

Date:21160

Attachments: Budget and proposal

Diatribution: Original only

91-22

[PAGE 46]
91-27

[PAGE 47]
Grant for : Pharmacological screening and testing

Funds received: 20,500,00

Expenditures:

Wages and salaries10, 907.60
Equipment 3,623.93
Supplies; expendables 1, 303, 41
Animals 1,783.84
Overhead 2,880.60
20,499.38

#91-1

Total expenditures 20,499.38

13 Januury 196 0

91-28

December 31, 1959

[PAGE 48]
91.99

30 September 1959

Centlemen:

We are pleased to be able to tranamit to you the folloving runds: funds:

or \$800.00

Treaaurer'a Check No. 242234 drawn on for\$20,000.00.

These\_funda represent-a-contribution for the use of-your directors in carrying out the very vorthvhile research goals of your organization.

Yours truly,

Enclosures\_(2)

[PAGE 49]
No. - 571

Cost Account0525100y. 4901

Object Class

91-3)

[PAGE 50]
23 Soptembor 1959

MEMORANDUM FOR: CHIEE, FINANCE DIVISION

VIA

: TSS/Budget Officer

SUBJECT

1 MKULTRA, Subprojact 91, Involca f2 Allotment 0525-1009-4902.

\- l. Invoice No. & coverlog the above aubproject ls attached. Paymont phould be made as follows:

LS800.Q0.payable B 30 drawn on

Caghier'a check ln the amouat of \$20 000.00 payable ravn on

2. Please forward the checks to Chlef, TSS/Chomical Divinlon through TSS/Budget Officer by 7 October 1959.

3. Thla is a flnal involce. However, ainco it le anticipated that additlonal funde will be obligated for thie project, the flles should not be closed.

91.-31

[PAGE 51]
CERTIFICATIONS

(1) It is hereby certifled that thie is Invoice f2 applying to Subproject 91 of MKULTRA, that performance is aatisfactory, that services are belng accompllshed in accordance with mutual agroements, that a detailed agenda of the paymente and receipte ls filed ia TSS/CD, that thie blll ia juet and correct and that payment thereof bas not vet beea made.

Chief, TSS/Chemical Diviaion

Date:

(2)It is horeby certified that this Invoice applies to Subproject 91 under MKULTRA which wae duly approved and that the project is being carrled out in accordance with the memorandum dated 13 Aprll 1953 from the DCI to the DD/A. and the extension of thla authorityfa subsequent memoranda.

91-31

For Servicee

INVOICE

\$20,800.00

Research Director

[PAGE 53]
MEMORANDUM FOR: THE RECORD

SUBJECT

: Supplement to Project MKULTRA, Subproject 91

I. The purpose of this supplement ia to provide aaaitionat luuus I. The purpose of this supplement ia to provide additional funds to carry out an expanded animal screening of selected compounda directly related to the development of new chemicals which influence human behavior. The program provides fundamental information on structureactivity relationships among new psychochemicals. \_ It will provide an insight ipto the activity of chemical compounds of possible value for operational applications. The studies are-directed toward elucidating the relationship between this parameter and personality structure and mentatión.

2. In order to keep abreast of new compounds which have been recently uncovered and synthesized, it becomes, necessary to increase the advanced animal screening. It is expected that results obtained from the advanced screening will provide basic information required for research into the pharmacodynamics of new.and more effective compounds, The additional funds required for thie program for the year amount to \$20, 000.00. To this sum must be added \$800, 00 representing a four per cent service charge to

9132

DRAFT 18 September 1959

[PAGE 54]
who act as cut out, making the total amount \$20,800,00.

has requested that submit to them a summary accounting of funds received from and that they return any unused funds remaining at the conclusion of the program.

4,. It is not anticipated that any permanent equipment will be required for this program.

5. It has been agreed that documentation and accounting for shall travel expenses which are reimbursable by conform to the accepted practice of that organization:

6. The requirement for a-semi-annual informal accounting has been waived

7. All personnel connected with the planning and monitoring of this program possess Agency TOP SECRET approval. The project will he unclaasified after it leaves

APPROVED FOR OBLIGATION OF FUNDS: -APPROVED:

TSS/Chemical-Division

Date:97159

91-32

Distribution: Original only

[PAGE 55]
MEMORANDUM FORI-COMPTROLLER

ATTENTION : FINANCE DIVISION

SUBJECT

MKULTRA, Sobproject 9Aed Gnd Cettorizition no2

Voder the authorlty graated ia the menaorandum dated

13 April 1953 from the DCI te the DD/A, aod the extensloa of

this acthorlty la eubsequent memorands, Sybproject 91 hse

beea approved azú 320,a00.00 of the over-all MKULTRA project

funds bas beoa obllgated to cover the aabproject expenaes. This

obligetloa of fuods ehould be chargod to Allotment 0525-l009-4902.

APPROVED FOR OBLIGATION Or FUNDS:

Datar

Renearch Director

Distrlbstloa: Ovig k 2- Addrenaea-

1- TSS/OC
1- TSS/FASB
2TSS/CD

91-33

19 6eptember 1959

[PAGE 56]
Gentlenen:

Wa are pleased to be able to tranamit to you the following funds:

Theso funde represent a contribution for the use of your direetors in carrying out the very vorthvhile research goals of your organization.

goclosures (2)

Yours truly,

91-941

2 Pebruary 1959

[PAGE 57]
MENOPAJDUM POR: CHIRF, FINANCE DIVISICH

VIA

1 s/Budgat Officer

SUBJECT

MULA, SubproJect 91, Invoice f1
Allotment 9-2502-75-902

1. Invoice f1 covering the above mubprojeat is atteched. Paymoat should be made as follovet

8820,00,peyable dravn

0.510.00 payabl6 Ceshior'a crock in Firawa on

2. Please forvard the checke to Chief, Tes/Chemical Division through Tss/Budget Officer by Honday, February 9, 1959.

3. This ie a final invoice. Hovever, since it is anticipated that adaitional funds vill be obligatod for this projeot, the filee should not be clooed.

Chier TSS/Chemical Division

Attechaents: Invoice & Certificaticis

91.95

26 January 1959

[PAGE 58]
INVOICE

For Sorvices

CERTIFICATIONS

(1) It 1e hereby certifiod that this is Invoice f1 applying to Bubproject 91 of MULTRA, that performance 1a satisfactory, thet services are being accozpliehod in accorlance vith mutual agreements, that a detailod agenda of the payoents and receipts is filed in Tss/cD, that this bili is just and correot and that peyment thereof has not yet been made,

Chief. 1Ss/Chemical Division

Date:\_

(2) It is hereby certiried that this invoice applies to Subproject 91 undor HuLTRA vhich vas duly approved and that the project is being carried out in accordance vith the wemorandun dated 13 April 1953 fron the DCI to the DD/A, and the extension of this authority ia subsequent neaorenda.

Date:\_

Pesearch Director

91-35

[PAGE 60]
NONCAAMIUN PORI COAPTHOLLER

APTEETIOR

I Finance Divisioa

SUNCT

I Project MULTRA, Subproject 91

Under tho authority graated in the Mesoruoius datod

13 Apri1 1953 from the DCI to the DD/A, and the extorsion of this

authority in eubeequent assorenda, Subprofect 91 has teea epproved,

an \$21,320.00 of tha over-all project  uods has beea

obligated to corer the subproject's expenses and should te charged

to A1loteont 9-2502-75-902.

APPRVED POR CELICATICN OF FUNDG:

hasearch Direator

15 JAN led

Z1195N I CERTIY THAT PUNOS ARE AVAILANE ORICATCH EE 1595

Data

Pistributical

Orig a 2 - Addressee

1 -158/00

1 T8S/PASB

1- TSs/8rB

2TS8/CD

TSS/cD/A5 Jan 59

6817084 -36

15 Jauery 1959

AUTHORIZING CFFICER

[PAGE 61]
MEMORANDUM FOR THE RECORD

SUBJECT: Project MKULTRA, Subproject 91

The purpose of this subproject is to provide-funds to carry 1. on the advanced animal screening and certain parts of the pre-clinical pharmacology required by the program on the development of new psychochemicals. In addition, this phase of the program will automatically provide fundamental-information bearing on the problem of the structureactivity relationships among these compounds.  It viil aleo give a better insight into the problem of compound selection for operational applications and the relationship between/parameter and-the personality structure of the particular-person being studied.

2. Preliminary\_screening on the materials involved in this study has over the past three
Bbeen carried out at years. During this time the state of knowledge in this area has steadily improved so that it is no longer poseible for the work to be carried out by this contractor. The type of experimental work now required in the program is simply far beyond-his capability both in terme of equipment and personnal required-for-the job. For this reason the rate of expenditure
at on this preliminary screening work has stesdily dropped with time while facilities capable or carrying out the more advanced phases of the program were being located. The present view is that with e alight over-
B lap during this year between these projects, portion will be phased out at the end of the year to be replaced with this new facility. 3. The experimental design in this subproject is based upon results
Bderived rron eubprojects 22, 51, 70, 62, 58, 53, 46, 44, 45, the  work Tho personnel and consultants
H of the past three yeare, and projec
C involved consist of CD/Branch II personnel working with Drs. Because the work leads off almost immediately intocompletely unknown areas, all of these consultants will maintain a very close but informal surveillance of the rav data as the work progreases so as to be able to take advantage of every new development as it comes to light in guiding further work in the project.

4. As indicated in the attached proposal, the cost of this program for a period of one year will amount to \$20,500.00.: To this must be added a 4% service charge to ther who will act as cutout ao that the total cost of the project wiil not exceed

91.37

DRAFT

15 January 1959

[PAGE 62]
\$21,320.00. Charges ehould be made .against allotment 9-2502-75-902.

has requested that 5. The submit to them a summary accouniting of funds received And that they return any unused funde remaining at from the conclusion of the program.

6 It 1s not anticipated that any permanent equipment will be required for this phase of the program.

7. It has been agreed-that docymentation and accountifor travel shall conform to expenses which are reimbursable by the accepted practice of that organization.

8. The requirement for a semiannual 1nformal accounting has been vaived. MONILUT uuitatina

9. All personnel connected with the planning and matataining of C results of this program possess Agency Top SECRET approval, however none with the exception of 1s Bof the peraonnel of cleared and none will be made witting of Government intereat, The project will be unclassified after-it leaves the

APPROVED FOR OBLIGATION OF FUNDS:

Date 1 1 :

Orig only.

Attachment - Proposal

DRAFT

91-37

[PAGE 63]
PROPOSAL

It is proposed to conduct certain biological tests of a pharmacological nature as directed by the Sponeor of this project on chemical materials and extracts to be furnished by the Sponsor. These tests may involve enzyme preparations, small-animal work and/or clinical \_work\_in certain casee as indicated-in each particular inatançe. The Sponsor will have full control of the methods and procedures to be folloved in the vork and it is underatood that these-will vary düring the course-of the project depending upon research findinge in-other facilities.working in this\_same general biological.program.

In addition, .as time and funds allow, pilot experiments will be performed utilizing \_varioua known substances having effects on the central nervoue system-in an effort to refine and improve the present capability of detecting and characterizing such activity in small animals. Attention will also be given to the problem of extrapolation of results between various species\_of\_animals.

It is expected that the attached iudget will be required:to carry\_out the program outlined above for-a period of one year.

91-32 15gom1919

[PAGE 64]
,\$12,000
Selaries..
Overhead (25% of Salaries).. 3,000
500
Travel,.
Service (Analytical, ete:). 1,500
3,000
Supplies and Materials
500
Contingencies
Total \$20,500

[PAGE 65]
PROPOSAL

During the past few years a great deal of progress has been made in relation to the function and metabolism of various anatomical divisions of the human central nervous system, This progress has to a great extent been fostered and abetted by the study of the effects of drugs on this very complex system. These drugs have mainly been utilized as tools in attempts to develop the relationships between cerebral metabolic processes and brain function as expressed by individual mood and behavioral changes.

In general, pharmacologists are just beginning to realize the potentialities of work in this field and have not as yet adjusted their research goals and techniques to take full advartage of existing knowledge. The general tendency in this respeçt is to attempt to apply sim ple modifications of existing techniques to the study of these phenomena. This approach is-useful but entirely inadequate to produce progress consistent with that in other fields of medical research. A further problem of significance in relation to this work is the fact that it has developed to a great extent on the clinical side with far too little attention-paid to the general pharmacology of the drugs concerned. Without such basic work progress will continue only on a pure chance basis with littlc theoretical background.

Therefore it is proposed to:

l. Design and test methods involving experimental animals which will discriminate between drug-produced, generalized depressed states and generalized excited states of thecentral nervous system and those particular and specific states or effects which can eventually. be related to overt behavioral responses of a sort which entail some possibility of practical exploitation. In this process it\_would be\_expected that drugs having a more "pure" type of action than those presently available would be discovered.

2. Discover and test materials having specific effects either in the periphery or the central nervous system which result in the distortion of nerve impulses in the sensory tracts of the nervous systen.

3. Validate the above methods and effects in normal humans and relate them to alterations in mood and behavior in as objective a fashion as possible.

91-3S

[PAGE 66]
4. Establish and maintain facilities for those general pharmacological procedures, i.e., the relationships of the unknown drugs to the known humoral agents, etc., which are necessary in order to describe intelligently the action of the new drugs for their application in the above-mentioned tests.

It is felt on the basis of present knowledge that such a program as that outlined above will go far to bridge the tremendous gap in knowledge which presently exists between known drug-substrate relationships and the overt manifestations of these drugs.

9E1

91-58

2

[PAGE 67]
Memberships: Society Experimental Biology Society. Pharmacology Cancer Society Academy of Medicine

Research: Conducted intensive research on; endocrine glands, (insulin, posterior pituitary, thyroid, anterior pituitary) chemotherapy, alcohol, virus and cancer.

Pharmacology of dinitrophenol