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Do. you have any information on the stability of C-5? We have been making a solution of this material in 95-per cent alcohol in a concentration of 1 mg/ml. The solution is originally light-brown in color, but after a day or two it becones blueish, as if it ccntained methylene blue. Currently we are preparing the solution fresh on the morning it is to be used.

We have now given as much as 3 mg of C-5 per 70 kg. of body weight without observing any definite subjective effects. There is a suggestion (subject to proper controls) that the following may be occurring: drop in diastolic blood pressure, incrcase in pulse rete, and elevation in body temperature. It is already apparent that C-5 orally will be far less potent than C-9.

I have not yet received the additional supply of K-302, or of the crude material.

Yours very sincerely,

Narris Skeee

Harris Isbell, M.D. Director

Hi:rn

13c

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Madanal lastirase af Mentsi Hsaich Addictioa Renearcà Ceelar U.3. ublic Heshh Sarrie Kpital Lexiogta, Laatucky

DEPARTMENT OF HEALTH, EDUCATION. AND WELFARE

PUBLIC HEALTH SERVICE 2h1 February 1958