[PAGE 2]
MEMORANDUM FOR: THE RECORD

SUBJECT Schedule.of Grant Payments MKULTRA 22

November 1961 to November 1962

Due Nov 1, 1961 \$3,852.00
Due Feb, 1961 3,852.00
Due May 1, 1961 3,853.00
Due Aug 1, 1961 3,853.00

22 November 1961

[PAGE 3]
MEMORANDUM FOR: THE RECORD

SUBJECT : Schedule of Grant Payments MKJLTRA22

November 1959 to October 1960.

TOTAL GRANT 11,567.00

7 October 1959

[PAGE 4]
Punds-cuzrent year: \$11, 567.00
Purpose: Isolation end investigation of the active principals of certain botanicals of interest.

Statusi Final frtctions aro being studied on the Rivea corymbosa neparation,. considerable progreas has been made on the separation of tho active constituents of Amanita muscarla, and a start has been made on the separation of Rhynchosia phaseoloides

[PAGE 6]
A,B, C}

From: principal investigator

Re: Final financial-accounting-for renewal of research-grant entitledu

Period of grant:Noyember 1,1962 July 15, 1963

For professional services renderei-in-research \$4500.
Travel expenses and return by auto and plane 1115. 1950 Living expenses at 140. Laboratory fee at

Total expenditures \$7705. Total funds from grant 7705. Balance -0--

This is a correct accounting of funds rəceived by me as

April 17, 1964

[PAGE 8]
Incorporated

B. C

Your check-for \$2,575.00, representing the third quarterly

payment for  research work, was received today.

Thank you for taking care of this matter for us.

Very truly yours,

#22 22.8

OFFICE OF RESEARCH ADMINISTRATION

May 1, 1963

[PAGE 9]
22

[PAGE 10]
aldached are two co pies of accowiting on the grort fauds at oiel Checked this and all appeor to he ine order. of there are any quetons jiet let reknow

Cordielly

[PAGE 11]
Expenditures:

Telegraph service9.27
Telephone169.06
Miscellaneous 87.06
265.39
Overhead @1376 of direct-costs=1,053.52

Balance

I certify\_that the above statement of account is correct to the best of my knowledge

Business Manager

I have examinel and approvod the suomitted expenditures.

V TSD/Biological Branch

[PAGE 12]
22.12

6 August 1962 A, B, C

MEMORANDUM\_FOR THE RECORD

Extension of Grant for

Authorization was given this date to extending

grant time until 1 August 1963.

[PAGE 13]
SUBJECT Support of Research on

1. This date discussed in detail the 'status of our research on the physiologically active principles of the mushrocm with the principal investigator on this project, has made outstanding progress in his laboratories in The research has progressed to the point where it is important to engage in more detailed phases.

2. In discussing the projected research, said that he was unable to engage in certain critical phases due to lack of contact with certain types of apparatus, He was of the opinion that it was most-important to bring into the. research picture an outstanding research worker who was knowledgeable in the field of drugs natural products:

3.Following consultation with discussions were held between land myself, It was the consensus that fhis work be undertaken in the laboratories of was in complete agrecment with: this since it would permit him to devote full time to his research andat the same time, obtain much-needed-information on researches first hand.

4. pointed out, however, that he would be unableto carry out such a program without additiónal support. He stated that he had been in correspondence wrtn ard had received several cordial invitations to work in laboratories. pointed out that his expenses would be in excess of \$10,000,owing to the. fact that hewould have his family to transport and take care of. He was advised that the grant could not undertake support .to this extent, but that it would.be possibe to use about  of the existing grant to reimburse him for his professional services, transportation, anda portionof his living expenses while in residence at He was informed that. he, personally, would have to make his own arrangements about the additional funds required. stated that this was quite agreeable to him and that he would take the necessary steps.

26 March 1962

J2.12A,B, C

MEMORANDUM FOR THE RECORD

[PAGE 14]
5. Arrangements were made vith whereby t of the grant would be withheld from and given directly in support c researches al This was concurred in by Chief, TSD, and

2

[PAGE 15]
Report of Expenditures November 1, 1960 to November 10, 1961

Expenditures:

#3,850.00
1,107.10
1,150.65
684.99
148.10

Overhead @ 15% direct costs

Total Expenditures

Balance

I certify that the above statement of account is correct to the best of my knowledce,

Businsss Manager

[PAGE 18]
12 Ostober 1961

1. Invoice No. 11 1n the anount of \$16,026.40 covering the above subproject is attached.: Payaent shculd be made es follovs:

Cashier's chack in the amount of \$15,hl0.00, drawn on Cashier's check in the aaount of \$616.40, drava on a

2. The checks ahould be forvarded to Chier, TSD/Research Braneh, through Teo/Budget Officer, no later then 3 Jovember 1961 Thls is a final invoice. Rovever, since it is enticipated that additional funda vill te obligeted for thia project, the files should not be olosed.

Chief T8D/Research Branch

Distributiont . Orig & 2 - Addreosee

216.+0 CHECKN IN THE AMOUNT OF S. RECEIVED.

[PAGE 19]
Invoice No. 11 1n the sacunt or \$16,C26.40 covering the above subproject is attached. Paysent ahould be sade as follcws:

Caahiar'a chack in the eoount of \$15,410.00, dreva cn Cashier'a check in tho amcunt of 616.40, drava on a

2. Tha checks should bo forvarded to Chlor, TSD/Reseerch Branch, tbroueh SSo/Budget Orricer, no lator then 3 Noveaber l561 3.. This 1s a finel invoico. Hovover, sinco it is anticiated that madltional funds vill be obligated for this project, tho files ahould not be closod

Chief TSD/Research Braoch

Distributiont Orig & 2 - Addresace

1 - TSD/FASS
2 - TSD/RB

I CERTIEY TAAT FUNDS ARE AVAILABLE 18,9OSUICATION RSEROCT NS. -632CARGE TO AUC NDG N

[PAGE 21]
INVOICE

\$16,026.40

CERTIFICATIONS

(1) it is bereby certifed that this is Inciee 11 appiing to Sub-prejeet No. 22 of MKULTRA, thas performenee is sarisfactery. that serviess are being accomplished in accordance with mutual agreements, that a detailed agenda-of the payments snd receipts ia cn file in TSD/RB, that this bill is just and correct and thas payment therecf bas not yet been made.

Chiet, TSD/Reseaveh Branch

Date:

22 (2) It is bereby certifled that this involeo applics to Subprojeet of MKULTRA which was duly approved, and that the project is being carried out io accordance vith the memorandum of 13 April 19s3 frem the DCi to the and the extenaion of this authority in subaequent memoranda,

Researeh Directer

[PAGE 22]
Cost Account g

Object Class

一

[PAGE 23]
Proiect MKULTRA, Subproject /22
Additlonel Authorization #9

Under the authorlty granted in the Memorandum dated

13 April 1953 from the DCI to tho and the extension of this authorlty in subsequent memoranda, Subproject 22 has been approved, and \$16, 026.40 of the over-all project MKULTRA fands has been obligated to cover the subprolect's expenses and ahould be charged to Allotment 2125-1390-3902.

APPROVED FOR OBLIGATION OF FUNDS:

Chtef, TSD/Research Branch

Distrlbutlop: Orig & 2 Addressce 12 TSD/OC
-TSD/FASS
2 - TSD/RB

I CERTIFY THAT PNOS ARS AYAILABLE639CHAG: TO ALONET N

27 September 1961

[PAGE 24]
MEMORANDUM FOR: THE RECORD

A,B,C

SUBJECT : Project MKULTRA, Subproject #22

1. The purpose of this Subproject is to provide funds to continue the researches of Prof. on the isolation of compounds from natural products which have psychogenic properties. Prof. Is concentrating his studies on isolation and identification of active materials in the fungus Amanita muscaria, Studies will be extended to active principles in Rhynchosia phaseoloides.

2. Progress in the studies of Amanita has been significant to date. It is belleved that the chemical entity primarily responsiblo for the hallucinogenic effects of Amanita muscaria has been isolated. Because of the extremely small amount in the fungus, and due to the lack of sufficlent quantities of plant materlal the amount isolated has been insufficient for complete structure elucidation. Effort during the coming year will be directed to obtaining adequate supplies of fresh material and the carrying out of various extraction and concentration procedures.Chemical and biōlogtcal techniques will be utilized to identify and characterize the active principles which are - of interest to TSD.

24.23

27 September 1961

[PAGE 25]
for trausfer of funds to the investigator. The estimated cost as outlined in the budget proposal is \$15, 410.00. To this must be added the 4% service charge to the cutout, making the total cost for one (1) year not in excess of \$16, 026.40. Charges should be made against allotment 2125-1390-3902.

4. A Memorandum-of Agreement has been sigaed by the contractor whereby title to permanent equipment is retained by the in lieu of higher overhead charges-and arrangements,are made for account ing for funds disbursed under the grant.

5. It has been mutually agreed that documentation and accounting for travel expenses under the grant which are reimbursable by the shall conform with the accepted practices of that-institution.

6. Prof.holds a covert clearance under Project MKULTRAand has agreed to comply with the terms of the Mémorandum of

Agreement.

APPROVED FOR OBLIGATION OF FUNDS:

Date:\_

Distribution: Orig. only

TSD/Research Branch

22-23

will serve as cutout

Attached: Budget

[PAGE 26]
Investigation of the Fhysiologically Active Prineiples of Amanita Muscêria and Other Plants of Potential Medicinal Value

RENEWAL OF A RESEARCH GRANT

[PAGE 27]
BUDGET PROPOSAL 1961-62

Salaries ard wages--

Post Doctorate (12 mo.) Director's stipend (3 mo.) Student help

Sample collection and preperation --

1,000 pounds of Aranita Muscaria at \$2.00/1b., etc. \$2,500

Analyses, literature-and:speciel chemicals, etc.-- \$ 500

Unimelt Meiting Point Apparatus Rotary Molecular Still,Ozone Meter

Overhead 15%

\$13,400 2,010 \$15,410

[PAGE 28]
Theee funda represent a contribution for the use of your directors in carrying out-the very.worthvhile reeearch goals of your organization.

[PAGE 29]
29 November 1960

1. Invoice No. 10 in tho emount of \$9,645.38 covering the above aubproject is attached. However, due to refunds of \$665.43 froa thia project (as per attachent) payment should be made as follovs:

Caabior's check in the amount of \$8,634,57, drawa on a Loatep benk Caahier's check in the anount of \$3h5.38, dravm on a aaaupn benk. 7979.95

TSD/Research Branch

Attachmentt Invoice & Certifications

Distritutio: Ortg & 2 - Addredsee 1-TSD/FASS

CHEOKTE AMOUNT OR SA3CHECKEDAN THE AMOUNT OF SfS REOEIVGOTADEC

[PAGE 31]
For Services

\$8,979.95 \$9,672.00

CERTIFICATIONS

(1) It is hereby certified that this is Invoice No. l0 applying to Subproject 22 of MaLTRA, that perforwance is satisfactory, that services are being accoaplished in accordance with mutual agreements, that a detailed agenda of the payuents and receipts is riled.in TSD/ RB. that this bill is juet and correct and that payment thereof has not yet been made.

Chtef, TSD/Research Branch

Date:

(2) It is bereby certified that this invoice epplies to Subproject 22 upder MLTRA which was duly approved and that the project 1s being carried cut in accordance with the\_memorandum dated 13 April 1953 from the DCI to the DD/A, and the extension of this euthority in subsequent mezorenda.

Datei

Research Director

[PAGE 32]
(3) It is horeby certified that Under subprolect 22 at the close of FY59 a balance of \$665.43 representing umused funds remained in subproject 22. Additional funds (FY 1125-1009-1902) have been arproved for continuing subproject 22. Therefore, it is requested that \$665.43 of Iavoice No. 10 be crodited subproject 22 as a return of unused funds (FY 9-2502-75-902), M0R 2707.

Chief, TSD/Research Branch

Research Director

[PAGE 33]
Cost Account1122109. 1902

Object Class

[PAGE 34]
15 November 1960

MEMORANDUM FOR: COMPTROLLER

ATTENTION : Finance Divlslon

SUBJECT : Prolect MKULTRA, Subproject 122 Additional Authorlzatien \$8

Under the authority granted in the Memorandum\_dated

13 Aprll 1953 from the DCI to the DD/A, and the extension of

thls authority in subsequent memoranda, Subproject 22 has

been approved, and \$9, 672. 00 of the ovor-ali project MKULTRA

fuade has teen oblligated to cover the subproject's expenses

and ahould be charged to Allotment 1125-1009-1902.

981 TSD/Rosearch Branch

APPROVED FOR OBLIGATION

OF FUNDS:

A

Research Director

Date:\_

Diatribution: Orig. & 2- Addressee

1>TSD/OC A--TSD/FASS 2-TSD/RB

TSD/(15 Nov.60)

[PAGE 35]
15 November 1960

MEMORANDUM FOR: THE RECORD

SUBJECT:Project MKULTRA, Subproject#22

1. The purpose of this Subproject is to provide funds

to continue the research of Prof. n the isolation of compounds having psychogenic and related properties from natural products. Prof. is concentrating his atudies on Rivea Corymbosa variety and Amanita Muscaria and has isolated some active materials which are of interest.

2.Difficulties in obtaining properly documented raw materials in sufficient quantity for further research have\_been to-a-large extent overcome. Considerable renewed interest on the part of several drug companies of foreign origin in related fungi and plant materials believed to have central nervous system activity indicate that there may be chemical compounds in the natural products under study of considerable TSD iaterest,

serve as cutout for transfer of funds to the investigator. The

22-32

[PAGE 36]
estimated cost for the coming year of the work is \$9, 300. 00.

To this must be added the 4% service charge to the cutout,

thus the total cost for.onè year will not exceed \$9, 672, 00.

Charges should be made against allotment 1125-1009-1902.

4. A Memorandum of Agreement has been signed by.

the contractor whereby title to permanent equipment is retained

by the University in lieu of higher overhead charges aad arrange-

ments are made for accounting for funds disbursed under the

grant.

5.It hag been mutually agreed that documentation and

accounting for travel expenses under the grant which are reim-

bursable by the University shall conform with the accepted

practices of that institution.

6. Prof. holds a covert clearance under Project

MKULTRA and has agreed to comply with the terms of the

Memorandum of Agreement.

APPROVED FOR OBLIGATION OF FUNDS:

Date:1118/60

Attached: Budget Distribution: Original only .nal only

J2-34

[PAGE 38]
for renewal of support to investigate

The Physiologically-Active Principals of -Amanita Muscaria end Rivea-Corymbosa

Principal Investigator

[PAGE 39]
PROORESS REPORT

for

Grant Fiscal Year 1959-60

During this year work has progressed to the point where crystal
line substances with physiological action have been isolated from
Rivea Corymbosa and AmanitaMuscaris: Rather than review all the
work in detail two papers are attached which describe the principle
aspects of the investigation during the year. The first or these
is a paper which hes been submitted for publication in regarding Rivea Corymbosa.The second is an adoption of aper regarding Amanita Muscaria which Was presented before the August 15-25, 1960.

F2-34

[PAGE 45]
SLIDE V 11 A,Mel0 - Taeivatee, solusle extract ie trdolic viid a atrong fvcal cior. roliov ain ssslasiac Pollceyen, vaobtalaed traces.<t.a
(ar the grdoecuca used P7 ato 15 secn 12 cot steiler
orystalltae cospqund wh cn bas zot teen iisntiried.
to psiloeybn, oufotéatd aad related coacouede Faper carcdatosranay has chowa the
presence or irscle ssetie acid anlitryptopaece 1a thts.zrsetlon
S1708 1X co collected about.200 lb. or Aashtta
Mascarts for our work ihs fresb planta sere faasdiately dropvea into metaenal

[PAGE 49]
Research Plans for 1960-61.

As indicated in the accompanying progress reports and papers related to the research supported by the grant, several crystalline substance have been isolated from Amanita Muscaria and Rivea Corymbosa. Future work will be organized to accomplish the following objectives:

1. Ascertain, by means of biological testing, which, if any, of the crystalline materials exhibit significant physiological effects in test animals. (This work is being carried out under the supervision of Dr at the

O,C

2. Complete fractionation and purification of crude concentrates which exhibit physiological effects in test animals.. When pure crystalline substances are isolated they will be identified or structural elucidation will be attempted.

3. For those substances, which exhibit significant physiological effects and which have novel structure, an attempt will be made to synthesize them and compounds with related structure in order that relative physiological activity can be determined.

At.the recent it yas revealed that Dr. Dof has isolated three indolic compounds related to Lysergic acid from Rives Corymbosa. Also it was learned by private conversation that research teems of several of the countries leading drug firms-have isolated flavanoid glycosides from Rivea Corymbosa. The structures have not been determined nor has work been published other than that by and in (1960). As a result of these deveropments less emphasis viir de directed toward continuation of this investigation. Dr who as a pre-doctoral graduate student worked on this problem, is now located at and plans to complete structural elucidation of the glycosfde Isolated in our laboratory from Rivea Corymbosa. If it is possible to obtain a sizable quantity of Rivea Corymbosa from an area inama where the plant is used for medicinal or occult purposes, then it is proposed that the sample be carefully investigated to ascertain if it contains indolic compounds or glycosides significently different from the samples collected in areas where the plant is not utilized for its physiolcgical action.

32

[PAGE 50]
J238

PROPOSED BUDGET FOR FISCAL YEAR 196O-61
November 1, 1960 - 0ctober 31, 1961

Research Fellowship (a) \$200 per month ----------------- \$2400

Msellanous student help (a) 1.50/hr. (400 bra.) 600

Stipend for senior investigator (during summer) -------- 1500

Special chemicals, naturak product samples, and 500 supplies (expendable)---

Special analyses on research samples -------------------350

Travel and communication in connection with project ---- 600

Special books, reprints, manuscript and slide preparation and translations related to project --- 150

Capital Items:

l. Ozone meter for ozonolysis apparatus which we have--- 100

2. Matching funds for photoelectric attachment for Model No. 80 Rudolph Polarimeter ------- 500

3. Components (sweep unit, coils and probe) to adapt our NMR for fine line work in connection with project --------- 1400

Indirect costs (15% of request) 120/215

Total request in renewal of grant ---------- \$9300

Signed/

[PAGE 51]
Boport 02 Expenlstures Moveber 1,.1959 - October 31, 1960

Puna 6795-76 OLOLTQU

11,07.00

Exqenditurest

Salarice and Vagoe (incluting Pellovehipo). \$5,509.00 1,010.79
Suplies and Expensca 1.197.00
pouipoxont 1.454.78
ovoixed Total Expanlitues

20,401.57

Balanco as of Cotober 31, 1960

€669.43

[ have exemined and approved the sutaitted expenditures.

I certisy that tho ebow ateterent of account to coracctatr B

Daten (/1%0

Iil/Chenical Division

BunineseHanaces

BUSINESS OFFICE

[PAGE 52]
USINESS OFFICE

Report of Expenditures November 1, 1959 - October 31, 1960

Pund 6795-76 OLOLIUQUI

INCOME:

\$11,067.∞

Expenditures:

Salaries. and Wages (including Pellowshipa) \$5,909.00
Supplies and Expenses 1,840.79
Equipoent 1,197.00
Overhead 1,454.78
Total Expenditures

Balance as of 0ctober 31, 1960

\$665.43

I certiry that the above statement of

Business Manager

[PAGE 53]
Report of Expenditures Movenber 1, 1959- 0ctober 3, 1960

7 Pund 6795-76 OOLTUQUI

Expenditures:

Salaries eni Vages (incluliing Fellovehipa) \$5,909.C0
Suppliee and Eqensse 1,840.79
Equipoent 1,197.00
Overtead 1,45h.78
Total Expenditures

Balance a8 of October 31, 1960

\$665.43

I certify that the above statement of account 1g correct.rua

I have oxaained and approvec tho oubmitted exponditurcs.

TSS/Chezical Division

BUSINESS OFFICE

CT-ef

Iaton 2.4 Mald1 961

[PAGE 54]
Attached are tvo copies of an application for reneval of the grant which pow supports a rosearch project under py supervision. An account of funds for the past year vill be supplied by our fiscel office at the end of the ponth. Is there is adáitional information vhich you desire, I vill be happy to try ani supply it. I vould like.to express my apprec! ation for your mupport mhich is making possible the research reported in the attached applicetion.

[PAGE 58]
27 Jenuary 1960

SUBJECT : Action on MKULTRA Audit Exceptions -- TSS/CD

SP#22

A. 31,703.57 was used for SP/51 per memo dated 21 August 1959. B \$1.487.50 being held in will be utilized on another project in the near future.

2

[PAGE 59]
Report of Kxpenditures July 1 to October 31, 1959

Bund 6795-76 OLOLIUQUI:

Overdraft, June 30, 1959 B \$ (185.32) 5,365.00
Income: \$5,179.68

Kxoenditures

Salaries & Wages (including-fellowships) \$1,960.00
Supplies and Expenses 334.24 1,294.63
Equipment
Overhead 1,590.81 mn+n1

5,179.68

Balance, October 31, 1959

I have exanined and approved the subaitted expendituros.

A

TSS/Chemical Division

Date: 217\~- 1941

[PAGE 60]
, Executive Secretary-Treasurer

Enclosed is the-financial-report-as prepared by our treasurer on the grant which your organization made to Dr. The report covers the full period from November, 1957, to June 30, 1959. We will-be happy to furnish further itemizing should you so require.

I am happy co report that considerable progress is being made C on this rather difficult project.Dr. has two very
promising doctoral candidates assigned to the problem. They are devoting a great deal of time and concentrated effort to this investigation. We are grateful to the
Mte for the fine support this organization has given us for this particular investigation.

Executive Director

July 30, 1959

[PAGE 61]
7-47

Period of Report November 12, 1957 to June 30, 1959

Fund 6795-76 OLOLIUQUI:

Expenditures

Salaries and Wages Supplies and Expenses Equipment Total Exrenditures

Overdraft, June 30, 1959

\$7,141.73
1,418.38
13,309.21

21,869.32

\$185.32

I have examined and approved the submitted expenditures.

Chief TSS/Chemical Division

Date.u

[PAGE 62]
We are pleased to be able to transmit to you the followiog funds:

Check No. drawn on the E , for \$11, 567.00. E
Check No drawo on of for \$462.68

These funds represent a contribution for the uae of your directors in carrying out the very worthwhile reaearch goala of your.orgaaization.

Yours truly,

Encloeures: (2)

[PAGE 63]
Cost Account-2000-75-902

Object Class

3z-49

[PAGE 65]
25 Auguat 1959

MEMORANDUM FOR: CHIEE, FINANCE DIVISION

MKULTRA, Subproject 22, Invoice 19
Allotmeat 9-2502-75-902

Involce \$9 coveriag the above subproject le attached. Payment should be made as follows:

2. The checke should be forwarded to Chlef, TSS/Chemical Divialoa, tazough TSS/Budget Ollicer, no lator than 4 September 1959. This ie a fizal involce. However, since It is anticipated that additlonal funde will bo obligated for thie project, the flles ghoald not be closcd.

[PAGE 66]
CERTIFICATIONS

(l) It is hereby certified that thie is lavolce No. 9 applying to MKULTRA Subproject 22, that performance ls satisfactory; that the servicos are being accomiplished in accordauce with mutual agreemcnte, that a detalled ageuda of the payments and receipto is on file In TSS/CD. that ths bill is just and correct and that payment thereof has not yet been made.

Chief, TSS/Chomical Division

(2) It ls bereby certified that thle lavolce applles to MKULTRA Subproject 22, which wae daly approved, and that the project ie being carrled out in accordance with the memorandur dated 13 Aprll 1953, from the DCI to the DD/A, and the extenslon of this authority ia subeequent memoranda.

Research Director

[PAGE 67]
GERTIFICATION

(3) It ia hereby certified that the program undar subprojocte 49 and 59 have been s sisfactorily completed and returned unused funds. However, subproject 22, which is still continulng also refunded money. Therefore tis requested that the amccnte a shown below on Invoice No. l0 of subproject 5i-B be credited to the subprojects as shown bolow.

\$1,703.57
3,224.87
63.73
6-2502-10-001
6-2502-10-001
6-2502-10-001

Chief, TSS/Chemical Division

Research Director

[PAGE 69]
MEMORANDUM FOR; THE RECORD

SUBJECT : Project MKULTRA, Subproject 22

1. The purpose of this Subproject is to provide funds to continue the research of Frof on the isclation of compounds having psychogenic and related properties from natural producta. is concentrating his studies on Rivea Corymbosa variety and Amanita Muscaria and has isolated some active materials which are of interest.

2. Difficulties in obtaining properly documented raw materials in sufficient quantity for further research have been to a large extent overcome. Considerable reneved interest on the part of several drug companies of foreign origin in related fungi and plant materials believed to have central nervous system activity indicate that there may be chemical compounds in the natural products under TSD study of considerable TSS interest.

3. will serve as cutout for transfer of funds to the investigator. The estimated cost 493c0 for the coming year of the work is \$ili,567.00. To this must be added the 4p service charge to the cutout, thue the total cost for one year 9672 wilr not exceed \$12,029.68.

4. A Memorandum of Agreement has been signed by the contractor whereby title to permanent equipment is retained by the University in lieu of higher overhead charges and arrangements are made for accounting forafunde disbursed under the grant. unda, disbu

[PAGE 70]
5. It has been mutually agreed that docunentation and accounting for travel expenses under the grant which are reimbursable by the University shall confor with the accepted practices of that ineititution.

6. Prof holds a covert clearance under Project MULTRA and has agreed to comply vith the terms of the Memorandum of Agreement.

Chief PSS/Chemical Division T50/Rexund Brond

A

APPROVED FOR OBLIGATION OF FUNDS:

Date: 6130159

Attached: Budget

Distribution: Original only

2

gz-54

[PAGE 71]
BUDGET FOR 1960

[PAGE 72]
Budget for One Year Renewal-of Research Project on Investigation of Amanità

Muscaria and Rivea Corymbosa - Nov. 1, 1959-Oct. 31, 1960

Research Fellowships - two (a) \$200 per month ................. \$4800.00

Senior Investigator - during summner............................ 1200.00

Capital Equipment - (Electric desalting apparatus, explosion proof homogenizer, vacuostat, spinning paper chromatography apparatus, etc.) ............ 2410.00

Special Chemicals and supplies not ordinarily.stocked by Department of Chemistry....... 850.00

Special analyses on research samples.............................300.00

Travel and telephone in connection with grant .................... 450.00

Miscellaneous - phottocopy, monographs, etc. .... 50.00
\$10,060.00

15% overhead ............ 1,507.00

Total grant request \$11,567.00

emisti

[PAGE 73]
6 Jamry 1959

KOOEAMUN POR: COETPLLER

ATTrasiOsFinance Division

Project , Subprojoct 22
adaitional Authorizetion f6

Under the authority graated in the Necorandua dated

13 April 1953 frm the DCI to the D0/A, end the extension of thie

authority in subsequent peuoreode, Subprojoct 22 has been epproved,

ani \$3gh.68 of the over-all project ULTaa funds bes beea

obligated to covar the subprojeot's expenses and ahould be charged

to A110tmont 9-2502-75-902.

A

AFPROVED FOR CELIGATION OF FUDSI

Chiot 288/Chenical Diviaion

Hesearch Director 7

11S8 9.2507.75.907

Orig 4 2 - Adáressee

1 - 1S8/00

TSS/FASB

1 - TSS/SRB

2 - TSS/CD

[PAGE 75]
2. The checks should te forwarded to Chief, Tss/Cheaical Diviaton, thurough Tos/Buigat Crlicer, no latar then 17 Nor. 58. 3. shis ie a fioal invoice. Ecvover, sinco it is anticipated that aiiitional Node will be obligatei for this project ths files shoul4 pot be cloord. a..

[PAGE 76]
(1) It is bereby certiried that this is Invoice No. 8 applying to NULTRA Subproject 22, that performance 1s satiafactory; that the services are being accoaplisbed in socordanco vith mutual agreeuents, that a detatled aganda of the payuente and receipts is on file in TS8/CD, that the bill. is just and correct and that payaent thoreof bas not yat been mede.

(2) It is bereby cortified that this inroice applies to HULZRA Bubproject 22, vhich we duly approved, and that the project is being carried sut in sccorience vith hhe meaarandua dated 13 April 1953, from the DCI to the 0/A, end the extension of this authority in subsequent nezoranda,

[PAGE 77]
Iavoice No. 6 is attached covering the above subproject. Payment should bo made as followst Casbier's check in tha amount of \$158.67, drawn on Cashier's check in the amount of \$3, 966.87, drawn on

2. Please forwerd the checks to Chief, TSS/Chamicel Division through TSS/Budget Oflicer by Tuesday. 18 June 1957. 9. This is a final invoice. A total of \$6, 188.00 was obligated under this subproject during FY 57. However since it is anticipated that additional funds will be obligated for thls project, the fles should not be closed.

[PAGE 78]
(1) It is hereby certified that this is Involce No. 6 applying to MKULTRA Subproject 22, that performance has been aatisfactory. that the services have been accomplished in accordance with mutual agreements. that a detailed agenda of the payments and recelpts is on flle in TSS/CD, that this bill is just and correct and that payment thereof has not yet been made.

Chief, TSS/Chemtcal Division

(2) It is hereby certified that this iavoice applles to MKULTRA Subproject 22, which was duly approved, and that the project is being carried out in accordance with the memorandum dated l3 Aprll I953. from the DCI to the DD/A, and the extenstoa of this authority in subsequent memoranda.

Research Director

[PAGE 82]
Tble is an invotce againet previously obligat.c fuds, Doc1 02 C11gst1cn: 30 0ctober 1958 Pur xoea of Projects Extraction of

[PAGE 83]
MEMORANDUM FOR THE RECORD

SUBJECT : Project MKULTRA, Subproject 22

l. The purpose of this Subproject is to provide funds tò continue the work of Prof. on the isolation of psychogenic compounds from natural producte. Prof, has been working on Rivea C Corymbosa and Amanita Musceria and has been able to isolate a number of interesting materials from these sources.

2. Progress -in this field has been sonewhat delayed due to\_difficulties in obtaining properly documented rav materiels; hovever, scurces have now been developed which sbould correct this difriculty and make possible the completion of the project, The recent success of the Swiss Chemists in isolating and elucidating the structure of a new psychochemical from a fungus indicates the feasibility and the necesaity of continuing work of this type.

3. The wiil serve as cutout B for transfer of funds to the investigator. The estimated cost of the vork is \$9,867.00.: To this must be added the 4% service charge to the cutout, thus the total cost for one year will not exceed \$10,261.68.

4. Prof. has signed the Memorandum of Agreement whereby title C to perwanent equipment is retained by the University in lieu of higher overhead charges and arrangements are made for accounting for funds disbursed under the grant.

to:DTIAL y auporitr : 187475 ate -june 677 E2 DPDET: CL BY 187475

22-66

DRAFT

23 October 1958

ososed tocERTIAL 7anthortof:187475 ate: Juno 1977

2IV2OET: CL BY 187475

[PAGE 84]
5. It bas been mutually agreed that documentation and accounting

for travel expeases under the grant which are reimbursable by the

Univeraity shsll confora vith the accepted practices or that inatitution.

6. Dr.  holde a covert clearance under Project MKULTRA and

has agreed to cogply with the terms of the Memorandum of Agreement.

Chief TSS/Chemical Divielon

Attachment: Budget

APPROVED,FOR OBLIGATION OF FUNDS:

osoded to: CONFIOENTUN

authority of: 187475

:a: June 1977

Donnceded o:toufEt by authority of: 187475 date: Juna 1977 4

E2 IMPDET; CL BY 187475

DRAFT

Date oil. S191S.

Distribution: Orig. only

INPDEI; CL BY 187475

2

[PAGE 85]
BUDGET FOR 1959-60

WARNING NOTICE

[PAGE 86]
July 1, 1956, through Oet. 1, 1957 Acct 570---Final Report

Balance. July 1. 1956 (Per prior report) \$1 730 74
Receipts: August 31, 1956, 4th quarter 1 325.00
Jannary 31, 1957. lst quarter 1407 50
March 18. 1957, 2nd quarter 1487 30
Junè 24, 1957, 3rd quazter 1.407 50

Total to be accounted for

Exoenditure and chargss:
Totel direct charges per-prior-zoport, 2/28/574 202 46
Salazies. 6 rooa, @ 150.00 900 00
Travel expense, Dr. t 30 00
Telephona, and talegraph 803
Supplies and Miscellaneoue 145 57

\* Cheek for \$1, 703. 57 to corar reñund of uneupended balancs fowardəd to

[PAGE 87]
2 November 1957

Dear Mr.

This ta to acknowledge the recelpt of the followiog checks ;

Check #G 20251 drawn on tho \$16,819.00.

Check #DM 43521 drawa on the for \$672.76.

Your generous contributions are greatly appreciated. The funds will be utilized by our Board of Directors in furthering worthwhile research projects in the field of medical sciences.

Yours truiy:

Rxecutive\_Secretary- Treasurer

[PAGE 88]
Summary of work, November 1, 1955 - September 25, 1956

Phyaical exanination of the soed used in this work roveals that two "typos" have been under. investigation Taxonomioally all the seed have boen called Rivea Corymbosa aithough one vorioty (the seed are the larger of the two varietios) originated in Kexico and one varioty originated in Cuba. The literature on the subjoct of ololiuqui, as far as I can ascertain indicatos that its use as a paychic drug has been restricted to Mexico.  This data. alone would indicate the probability thet the Cubon vsristy lacks sone physiologically aotivo component/ ynich the exican variety conteins. Experimental Work/in this laporatory has been largely restricted to the Cuuan variety(smali seed sinco only a very saall amount d tho Moxichn variety hes boen available. The chemical work, although not desigcd to compare the conpositien of the tro varieties hes indicated soze differenco in tho two. also physiological tests on huzans are indicatíve of a dirforence in the two verieties. This work is mhéh too incphclusive to bo auch more than speculation at thia timo.

In addition-to the lsolatio.. of glucose and hyároquinone as constituonts of ololluqui-as reported in the last progresa report, txo crystaliine fraotions have bcon isolated which see glther to oe alkaloid or glycoside. Due to the snall quántity of deed availablo tho amount of these crystalliro fracvions is extrenely snnll and little more than qu litstive tests bave been mede on thed. Experimoeatl tochniques, especialiy in extraction and soparationhave been perfected which willbe uaed to isolate pure çonbonents of tho drug which, just today has becomeayilablo in sufficient quantity to make the investigatiot|profitablo.

Plans for futiro investigation:

Now that 50 pounds of the Cuben vorioty and 10. pourds of tho Nexican variety are avsilablo, the following linos of invostigation will be actively pursuod.
1. Detemine conolusivoly if there is a chemical difference in the twc varietios of seed
2. Obtain ns many "puro"coaponents fros cach variety, using previously perfocted tochniques, as is possible.
3. Subait for physiologicsl tosting oucl"pure coanonent.

4, Subjeot oach "yuro" componont to choaical exanination to doteraine tho type of cospound, vhother it is a kmown-conpound ond its chonicol composition if it is a new cospound.

[PAGE 89]
Equipment (including larger scale
extraction and separation equipment)
and spooial chemicals \$1000.00

Saleries (one greduate essistant,:laborptory help ard direotoris stipend)..... 4000.00

Tota15950.00

[PAGE 90]
MEMORANDUM FOR: CHIEE, FINANCE DIVISION

TSS/Budget Officer

MKUL,TRA Subproject 22, Invoico No. 7
Al1otment 8-2502-10-001

1. : Invoice f7 covering tho above subproject ts attached. Payment should bo made as\_follows:

Caahier'e check in tho amount of \$16,819. 00 drawn on E

Cashier'e check ln the amount of \$672.76, drawn on-

Both checkashould be made payable to B

2. The checks should be forwarded to Acting Chief, TSS/Chemical Divielop, through TSS/Budget Officer, no.later than Friday, 18 October 1957.

3.This is a final involce. A total of \$17, 491.76 wae obligated under this.subprojact duringFY58. However, aince it is aaticipated that additional funde will be obligated for thls project, the flles should not be closed.

Acting Chlef
TSS/Chemical Divleion E

Attachraents: Invoice & Certifications

Diatribution: COrig & 2- Addrelseo 1 - Comp.xoller

14 October 1957

[PAGE 91]
CERTIFICATIONS

(l) It ie hereby certifled that this is Involce No. 7. applying to MKULTR R Subproject 22, that porformance has been satietactory. that the uorvices hava been accomplished in accordance with mutual agreemente, tuat a detailled agenda of the payments and recoipta is en flle in TSS/CD, that this bill is just and correct and that payment thereof has not yet been made

Acting Chief, TSS/Chemical Division

(2) It is bereby certifled that thle involce applee to MKULTRA Subproject 22, which was duly approved, and that the projoct ls beng carried out in accordance with the memorandum datcd 13 AprlI 1953, from the DCI to the DD/A, and the extenalon of thls authority in subsequent memoranda.

Research Director

[PAGE 94]
13 Apri1 1953 froa the DOI to Cha DO/A, cnt tba oxtenaion of this autbority in subeaquont recoranda, Subprojeot 22 bes beaa approved, a0d 617,491.76 0f the 0v2\~911 pr05902 1607.184 Cund3 ba3 bean obllgated to cover the mubprojoct's axpencos end ahould ts charged

[PAGE 95]
The purpose of this subproject is to provide runds to continue on the isolation of paychogenic con- C the work of Prof. pounds from natural products. Frof. has been working on the seeds of Rivea corymbosa and has been able to isolate a number of materials of potential interest in this field.

paychogenic types of materials, Prof. 2. With the advent of feasible laboratory methods for testing Preels that he wiil be able C to characterize the previously isolated materials during the coming year as outlined in the attached propoaal and also fractionate Rhynchosia phaseoloides for its active principle during the -seme period.

3. Prof. was previously located at University at He ig noW located at University as head of the department of Chemistry. This change in position will pot in any way interfere with the Agency sponsored work,in-fact ProfAvill have access to more and better-equipment and personnel for his research.

vill serve as cutout 4. The for transfer of funds to the investigator. The estimated cost of the vork for a periol of one year beginning 1 September 1957 1s \$16,819.00. To this must be added the 4% service charge to the cutout, thus the total cost for one year wil1 not exceed \$17,491.76.

5. Prof. has sigred the Memorandun of Agreement vhereby title to permanent equipment is-retained-by-the University in lieu of higher overhead charges and arrangements are made for accounting for funds disburaed under the grant.

6. It has been mutually agreed that documentation and accounting for travel expenses under the grant which are reimbursable by the University shall conform with the accepted practices of that institution.

7. Dr. holds a covert clearance under Froject MKULTRA and C

E2 IMPDET; CL BY 187475

16 August 1957

MEMORANDUM FOR: The \_Record

E2 IMPDET: CL BY 187475

[PAGE 96]
Domperaded to: CONFDEKTIAt by authority of: 187475 date:.June 1977

E2 IMPDET;.CL BY 187475

Acting Chief TSS/Chemical Division

Attachment: Proposal

APFROVED FOR OBLIGATION OF FUNDS:

Research-Director

Date 26Aang. 1957.

Distribution: Original only

Downgraded to:CONFDENTHAt by authority of: 187475 date: June 1977

E2 IMPDET; CL BY 187475

[PAGE 97]
CHEMICAL INVESTIOATION OF THE SEED OF RIVEACORYMBOSA -OLOLIUQUI

Work completed or in progresst

It has been ascertainod that there are at least two types of seed fron the plent idontified as Rivea Corymbosa One is found in Mexico the other in Cuba Their apparent composition and physiological action on organisms difrera

From both seed, glucose and hydroquinono have been isolated and identifiei, One additional compound has been obtained in crystaliine form, apparently
pure This compound is being atudied, Tro bulk of tho drug seems to be a glycosidio mixture. Thic mixture haa, to date, been subjected to nwroroua methods and teohiques designed to separate the component parts. None has proved successful. The mixture appears, on the basis of many tests, to contain a saall amount of alkeloid. It is not known whether the alkaloid is an integral pert of the glycoside or not
Physiologioal teats using animals and humans have been:inconclusivo and confusing. Enough positive
resuilts have been obtained, however, to point out the need for more carefully deaigned and controlled tests Complote idontirication of the unknown crystalline coupound
Perfon physiologioal tosts using thie compound. Fractionate the glycusidic mixture. Counter
current extraction whioh has not:been used to
date will be tried,
Identify and prove structuire of compononts of the mixture.

Forform phyaiological tests using the components of the glycosidic mixture.

WARNING NOTICE

SENSITIVE INTELLIGENCE SOURCES AND METHODS INVOLVED

[PAGE 99]
RECEIPT

Date:

640757

[PAGE 102]
Enclosed please find in duplicate our statement of funds on Alkaloids of the Drug known as "Piule" for the period from July 1, 1956 through February 28, 1957. The

balance shown thereon is \$1,h06.82. We thank you for your interest.in our projects.

Yours very truly,

WARNING NOTICE

SENSITIVE INTELLIGENCE SOURCES AND METHODS INVOLVED

[PAGE 105]
Receipt is hereby acknowledged of the following two checks:

Cashier's check No; Al06633, drawn on the dated 21 December 1956, in the
am8unt of \$1.983.33

富 Treasurer's check No. 147713, drawn on the dated 19 December 1956, in the amount of \$79.33.

[PAGE 106]
2. The checks should be forwarded to Chief, tss/Chemlcal Division, through TSS/Budget Ofllcer, no later than Monday. 31 December 1958, Other Involces will follow.

SIDNEY GOTTLIEB Chisf TSS/Chemical Diviston

[PAGE 107]
(l) It is hereby certified that this is Involce 4applying to MKULTRA Subproject 22, that performance is satisfactory. that the services are being accomplished in accordance with mutual agreements, that a detailed agenda of the payments and receipts is on file in TSS/CD, that this bill is iust and correct and that payment thereof has not yet

Chief, TSS/Chemical Division

(2). It is hereby certified that this Involce applies to MKULTRA Subproject 22, which was duly approved, and that the project is being carried out in accordance\_with the\_memorandum dated 13 Aprll 1B53, from the DCI to the DD/A, and the extenslon of this muthority in,subsequent memoranda.

[PAGE 109]
5 December 1956

MEMORANDUM FOR: THE RECORD

SUBJECT: Froject MKULTRA, Subproject 22

1. The purpose of this project is to provide funds to carry out the isolation and characterization of the intoxicating substances present in certain varieties of Rivea corymbosa. B

2. Dr. of tUniversity has conducted studies on this material which have lead to the development of methods which can now be applied to large samples of seed, thereby allowing the production of sufficient quantities of the active materials for definitive biological testing and characterization, Or.  has submitted the attached proposal to.carry out this work as directed by TSS/CD.

3. The as serve as cutout for transfer of funds to the investigator. The estimated, cost of the work is \$5, 950.00 for one year. To this must be added a four percent service charge for the amounting to \$238.00. Therefore, the total cost of this investigation for one year will not exceed \$6, 188.00.

4. In accordance with the- Memorandum of Undęrstanding with
Dr. , the University shall retain title to any permanent equip
ment in lieu of higher overhead rates. e

5. The has made arrangements for the return of unexpended monies received under a grant from the Fund and also has requested that the University submit to it a summary accounting for all monies.received therefrom.

6. It has been mutually agreed that documentation and accounting for travel expenses under the grant which are reimbursable by the University shall conform with the accepted practices of that institution.

Dovegraded to: Cemmb by aathority cf: 187475 cate: Juna 1977

E2 IMPDST; CL BY 187475

DRAFT

Downgraded tos SCHARENTIAL by authority of: 187475 cate: June 1977 1

E2 IYPDET: CL BY 187475

[PAGE 110]
BY 137475 7.Dr.holds a covert clearance under Project MKULTRA
and has agreed to comply with the terms of the Memorandum of
Agreement.

Chief, Branch II TSS/Chemical Division

Attachment: Proposal

Approved:

APPROVED FOR OBLIGATION OF FUNDS:

Sidney Gottlieo Chief TSS/Chemical Division

Research Director

Date: 7 955 DEC

Distribution: Original only

Dorngraded to CoTnt by euthority of: 187475 dste: Juno 1977

E2 IMPDST; CL BY 187475

Dovzraded to:CnERA by authority of: 187475 date: June 1977..

[PAGE 111]
Summary of work, November 1, 1955 - September 25, 1956:

Physical examination of the seed used in this work reveals that two "types"have been under investigation. Taxonomically all the seed have been called Rivea Corymbosa although one variety (the seed are the larger of the two varieties) originated in Mexico and one vriety originated in Cuba. The literature on the subject ofololiuqui, as far as I can ascertain indicatesthat its use as a psychic drug has been restricted to Mexico.This date alone vould indicate the probablity that the.Cuban variet lacks some physiologically active compontwhich the Mexican variety contains.Experimental work in-this laboratory has been largely restricted to the Cuban variety (saall seed since only a very-small-amount of the Mexican variety has been available. The chemical work, although not designed to compare the composition of the two varieties, has indicated-somedifference-in-the-two.: Also physiological tests on humens are indicative of a difference-in-the two varieties. This work is-much too inconclusive to be much more than spoculation at-this time.

In addition to the-isolation of glucose and hydroquinone as.constituents of ololiuqui as reported in the last progress-report.two crystalline-fractions have been isolated which seem neither-to be alkaloid. or glycoside Due to the small quantity of seed available the amount of these crystalliné.fractions isextremely small and little more than qualitative tests have been made on them. Experimontal techniques, especially in extraction and separation, have been perfected which will be used to isolate pure components of the drug which, just today, has become available in sufficient quantity to make the investigation-profitable.

Plans for future investigation:

Now that 50 pounds-of\_the Cuban variety and 10 pounds of the Mexican variety are aveilablo, the following lines of investigation will be-actively pursued.

1.Determine conclusively if-there is a chemical difference in the two varietiesof·seed.

2. Obtain as many-"pure"-components from each variety, using previousiy perfected-techniques, as is possible. 3. Submit for physiological testing each "pure"

4. Subject each "pure" component to chemical examination to determine the type of compound, whether it is a known compound and its chemical composition if it is a new compound,

WARNING NOTICE

[PAGE 112]
WARNING NOTICE SENSITIVE INTELLIGENCE SOURCES AND MÉTHODS INVOLVED

[PAGE 115]
I have examined andapproved the sutaitted
expend..ures. 1

[PAGE 116]
Receipt is hereby acknowledged of the following two checks:

Cashier's Check No. DM 35758, drawn on the dated April 23, 1956, in the amout of \$3, 533.34, payable to the

Cashier's Check No.3026ll, drawn on the dated April 26, 1956, in the amount
\$141,34, payable to the

Date: 8aay 19b

[PAGE 117]
1.  Luvoice 2 for the abovo subprojeot is attaehed. Par-Nant ahould ba made as follovst Cashier's cbeok in the anount of \$141.34 drawa on

2. The above checks should be forvarded to Chiaf, Tss/Cheaical Diviaion, through TSS/Budget Officer, no later than 27 April 1956. This is  final invoice. A total of \$5,512.00 vas obligatei under this subprofect during FX 56. Hovever, since it is antloipated that adaitional funds will be obligated for this profeat.. the files ghould not bo gloaed.

CERTIFIED.FOR PAYMENT OR CREDIT

[PAGE 118]
2. The above checka shoald be forwardod to Coies, TS3/Cheaical Diviaion, through T38/Baiget 0fficer, no later thaa 27 April 1956. 3.. Thia 1s a finsl invoice. 4 total cr. \$5,512.00 waa obligatel wder this sbprojegt doring 77 56. Bcwever, aluce it is aatioipatet that additional funds vill bo cblisated far this molect. the filea ahould not bo cloned.

GIDNEY COTILIKO Chte TSS/Chenical Divielcn

[PAGE 120]
We have your letter of March-29, 1956 relative to vour research grant made-for the investigations of our-Dr. It is indeed a privilege to serve-you and-your-profession in this connection, and our omission of acknowledgments and statements are due to prèssure of work-rather-than to lack of interest or gratitude in this and other. projects.

We have prepared a set of statements covering Dr. operation of your project-and are enclosing three copies, These consist of a summary of the entire period fron March l, 195h through March 31, 1956, supported by two detailed statements covering the periods March 1, 195h, to April 30, 1955, and May 1, 1955, to March 31, 1956.

These statements show receipt-from-you of-\$7;700.00 on the grant to November 1; 1955 and \$1,325.00 on the second grant (\$5,300.00) to October 31, 1956. Should you desire a restatement of the operations-to coincide with the grant terminations, we shall be happy to make them up accordingly.

Yours very truly,.

WARNING NOTIGE

SENSITIVE INTELLIGENCE

SOURCES AND METHODS INVOLVED

[PAGE 125]
The purpose of this memorandum of agreement is to set forth the mutual administrative responsibilities of the principal research investigator and the sponsor. Theretore, it is mutually agreed that: The principal investigator shall, submit to the sponsor, at six month intervals, an informal statement of exponditures of monies advanced for research activities. It is requested-that the statoment be submitted in ossentially the following form:

Personal Compensation (Salaries. Subject Fees)
Equiprent
Supplies and Services
Contingencies
Overhead

B. It is undorstood that any travel expenses-incurred in the furtherance of the-researoh program-will be accounted to the University in a manner- consistont with its ostablished practices and policies. .The principal investigator shall submit to the sponsor semi-annual reports on the technical progross of the research covered by these funds. D.Title to any permanent equipment shall be, retained by the University in lieu-of higher ovorhead rates.

[PAGE 126]
RECEIPT\_

I herehy acknowledgs receipt of the following:.

Treasurer's Check #T51699 drawa on the payable te B in the amount of \$70.66.

Orficial Check G 3951 drawn on. payable toR in the amount of \$1,766.66.

[PAGE 129]
(1) Ic is bereby certified that this 1s Invcdca 23 epplying to Subproject 22 of kLTRA, that perforaance is satiafactory, that tha cervices are. teing accomplished in eccordeoce vith mtual. egrcecsnts, tbat a datalled egenla of the paywents and recelpts 16 o flle in 2s/c0, that this. bi1l. 1s jost end correct snd thst payzant thereo? haa not yat teen pede. va.d

(2) It is boreby csrtified that this invoice appliea to Subpsoject. 22 of MloA wàieh ves dnly epproved, ent that tha project ia boing cerried out in accordsnce vith the memcasodua dated 13 April 1953 froa the. DCI to the DD/A, and the extensicu o? this euthorityin eubeequsntErworandasca

[PAGE 130]
I. Subproject 22 is a continuation of Subproject 1, which had as its scope preliminary work on-the-isolation and characterization of the alkaloids of Impomoa sidafolia Choisy (Rivea corym bosa) in order to determine their activities as agents affecting the central nervous system.

2. The results of the preliminary study are such that a full program of research-on this material-is desirable. However, further investigation is required to determine the best technigue to be used in-the purification-of certain glycosides. Dr. who C conducted the preliminary work, has submitted the attached proposal to carry out this work as outlined by TSS/CD.

3. The will serve as cutout' for transfer of funds to the investigator. the estimated B cost of the work according to the proposal is \$5,300.00 for one year To this must be added four percent service charge for the amounting to \$212.00. Theroforo, ths total cost of this investigation for one year will not exceed \$5,512.00.

In accordance with the Memorandun of Understanding with C Dre the University shall retain title to any permanent equipment in lieu of-higher-overhead rates.

5.The has made arrangements for the return of B unexpended monies to the Agency upon completion of the program. This agreement is maintained in the records of the Fund.

6. Dnhas agreed to comply with the attached Memorandun of Understanding. He has been granted a TOP SECRET Agency clearance and is. fully capabie of protecting the Government's interest in this project.

APFROVED:

Dato: 10/4155

Distribution: Original Only

Dowagraded to acNOPML by euthority of: 187475 date: Juno 1977 1

TSS/CD:(26 Septomber 1955)

E2 IMPDET: CL BY 187475

E2 IMPDET; CL BY 187475

[PAGE 134]
My letter to the on May 2 constituted a brief progress report of my work on-the project dealing with the drug "piule" Since that time, arrangements have been made with
C Dr. head of the Department of at to carry out physiological
Bthe tests on the purified glycoside obtained-from "Piule". These tests will take a considerable portion of the glycoside obtained from the "piule"on hand, however, Dr. of yourC organization has indicated that he-will make more of the drug available to me. When I\_obtain this new supply of the drug I plan to extract and purify a sufficiently large quantity of the glycoside so that, when it is subjected to splitting, the aglycone which is obtained will constitute a fraction large enough to be tested in detail. To date the aglycone has been obtained in minute traces as a dark tar.The only tests which it has been possible to carry out on this materisl are those using alkaloidal réagents.These tests have-indicated the presence of alkaloids The glycoside gives indecisive results when tested for nitrogen using the-sodium fusion technique.Quantitativ micro Kjeldahl determinations indicate O.70% nitrogen. Assuzing the presence of one nitrogen in the molecule and assuming that the glycoside is pure, this percentage-of-nitrogen would indicate a molecular weight of 2xlo. Due to the insclubility of the glycoside in the solvents usually-omployed-ir the Rast method for moleculer weight determinations, the molecular weight of the glycoside has not been determined.

The glycosidə has been fractionally oxtracted using various polar solvents. The fractions obtained from these extractions all have esssntielly the same ultraviolet spectra. This would indicate a fair degree of purity. The melting point is not sharp. As is characteristic of amorphous compounds it softens over"a wide range; melting between 120 and' l30c.

Further attempts will be made to fractionate this glycoside fraction by countercurrent extraction and also by altering the chromatographic techniques employed to date.

Microenzymatic methods will be employed to determine if the glycosidic linkage is alpha or beta.

Downgraded to: 6OHFNENMAL by authority ot: 187475 date: Juno 1977

September 10, 1955

[PAGE 135]
Additional paper chromatographic tests will be employed to determine whether or not the glyco portion of the glycoside is glucose or whether. some other sugar is-present.

Attempts will be mado to isolate sufficiently large quantities of the aglycone in-crystalline form so that in addition to the chemical tests. physiological tests may be carried out on it and the results compared-with those obtained\_on the glycoside.

Qualitative ahnd quantitative\_functional groupdeterminations will be made on the aglycone\_if\_it\_can\_be\_obtained in pure form.

In order that this project may be carried on more expeditiously I plen to hire one graduate student who can assist me in the work.

Proposed budget for one year

Equipment (including Extracto-natic, giant blendor, fraction 1000.00 collector=etc.). ...\$800:00

PDET: CL BY 187475

page 2

E2 IMPDET: CL BY 187475

[PAGE 136]
SUBJECT: Contact - Dr.

1. On this dey the writer spent two hours with Dr. discussing various aepects of his project on the isolation of the active principle of Rivea corymbosa.

2. The two bags of additional seed were given to Dr. He indicated that they would hold him for awhile, but that he could use at least five pounds-more in the coming year..

3. The question of accounting for the grant was briefly diacussed end Drpassed-along to us examples of-the three-month accountings which he routinely gets from the university. They.are attachei to the proposal discussed below.

4. Dr.submitted his proposal for the next year, which was discussed in detail with hin. The minor addition vas auggested to be added to the category of-"equipment". He has about \$470 -left in his present grent, as of today.He indicated that, if November 1, 1955 is the starting date for the new grant, and if he receives the first portion of the money promptly by that date, things will go smoothly.

5. Dr. raised some problems that re has in connection with having a groduate student. He wondered if there were security considera. tions in his having such an-assistant. The writer explained that there were none; that he should hire a person for the Job strictly on the basis of his qualifications.and iis personal ecceptability to

6. Dr also discugae, the possibility of another move in several years from now, and wondered what our attitude would be about this. He was advised not to worry about this until it became more imminent.

7. This being the writer's first contact with Dr. his impression of Dr was very favorable, particularly along the lines of sincerity and Integrity.

Chief TSS/Chemical Division

12 September 1955

2 IMPDET; CL BY 187475

MEMORANDUM FOR THE RECORD

E2 IMPDET; CL BY 187475

[PAGE 137]
Apperatus, Supplies. and Eoqense-March 195h Ck9893F-"Advertising in Chenical. & Engineering News Apc11 1954Ck20059-Wo Triunion cups & other fittings. Ck1037OF-Letoratory equlprent Extraction asgenblios & nantles CK 1C438F May 1954 Ck 106050-6 Heating nantel, gnd suppord Ck10727C60R050 Chemicals Ck 106500- Internal timer June 1954 0k 114570 J 3 cartons Sowex June 195h Ck 103801 Auolito exchanges & absorbent Jüly195h Ck 1191z - Potty cesh-

00 ∞
1620
10000
√2700
1500
L0000
-163 64
1636
1636
16364
1000
-16364
16364

[PAGE 138]
Ck 12043N - Deeninac model & filter Ck-12271 Laberatory Jock Funnels, rubber sheoting, blade acsenbly, ctc. Ck l2189N - Autemp heatep end blades Au7. 195)-Ck-21331-4060 Furnols, fil-ereand tuto Ck 11353F - Dioxene Yata Jv86h - Vol.1 The Alkelot Ck 11609F Ck 11.353F Tubeo, reduçera & matle Sept. 195 Heating pantlo and suppc Phensnthscne Ck.121260685 The Doors to Percoption CK.121 Chenical Coastitutior Dec, 1951 - C: 1205 Foulsie, Invertase Analy Jan. 1955- Ck 11851- 780. 1955- Ck 13279N

EQUIrESHE: Jan.20,1955 012ck 3443-121060 - 1 Kodo1. DK, Stectrophotoreeer,Beolea?12500 Less torne by Cheristry Dopt. ()

Balance Availsble in Fund at April 30, 1955

3/9/5 2.40 adspters 8//s4 6149- Connclng lule ieso Liller luake

[PAGE 139]
MEMORANDUM FOR: THE RECORD

1. The purpose of this addendun is to set forth the mutual administrative responsibilitiea of-the contractor and sponsor.

2. The above subproject represents the research progran of Dr. located at University, financed by MKULTRA, covering the period 28 January 1954 through 28 January 1956.

3. The mhas requested the University to submit to them a summary accounting of monies roceived-from the Fund. Also, they requested the return of any unexpended funds received under. a grant from the Fund.

4. Title to any permanent equipment\_purchased by funds granted the University.shall be retained by the University.in lieu of higher overhead rates.

5. It was mutually agreed-that docunontation and accounting for travel expenses which are reimbursable by the University shall conform with the accepted practices of that Institution.

6. It was agreed that technical reports reflecting the progress of the research program shall be submitted at mutually acceptsbla intervals

tha Sutd

SIDNEY GOTTLIEB Chief TSS/Chemical Division

Distribution: Orig & 1 - TSS/CD

[PAGE 140]
Extension of Time for Project MKULTRA, Subproject 22

Since Subprojeot 22 has expired and there are still funds remaining in the project, Subproject 22 is herebyextended for one year froa date of expiration.

[PAGE 141]
131201 245.33 CHECK#//20AN THE AMOUNT OF S303 RECEIVEO,

[PAGE 143]
Sudprojeet 22, Project UL2R Invoice No. 2, Allotment h-2502-10-001

1.. Invoice No. 2 for Subproject 22 of Projegt NULTRA is attached. This iuvoico is tho final one to to sulaittcd under Subproject 22 ast vhen paid, constitutes complote paypeut of this project. It is requestol thst payzent bo modo by teo cachier'p chocks for ș205.33 and35.133.3 cade out to tho 42×a696w60606m0000m56o Tho chooks should be sent to Chiof, T3s/co through TSs/Eulget Crricer /by 16 Augot 155h.

2. Tho tuo invotceo coverins thig Subproject aggregate ș8o08.0 and reprecent tho totol exponditure to bo pado under this Subproject. It is réqoosted, therefore, that the files on tbis Subprojoct. to olosed.

SIDNEY GOTTLEB Chief -Cheaical Division, TSS

Attachnt: Invoico No. 2 Certificaticns

-I CERTIEY THAT FU AVAILABLE:

OBLIGATION REFERENCEDO//O

Distributioni Addreasee - Orig. à 2y/a TSS/PAS3-1-- Camptroller-1 T0S/00- 2

CHARGE TO ALLOTMENT No. 10502-10-001 AUG 6 ENTD

H .

AUTHORIZING OFFICER

205.33 131207 U.NT. CHECR#BI208IN THE AMOUNT OF SS/33-0S RECEIVEO.AUG 12 1954

[PAGE 144]
(1) It is nereby certified that thla is Invoice No. 2 applyins to Subproject 22 of Project HulaRA, that techntcal porforuance by the NA wos datiafoctory, that the wors vas nccompliohed in occorlance vith the rutusl ogreeaent rooched vith thotxad Beorgy, that thia bill to Juot and corzeot nnd that payrent haa not yet been sado.

SIDNEY GOPELIRB Chtef, TS3/CD

(2) It is boreby certified that this invoice npplies to Subproject 22 uoler Projoct NKULrRA vaich vaa duly approved ani that the project has bech carrled out in occordance vith the DD/p rcnorandua to DI dated 3 April 1953 and the DCI menorandus to DD/A datel 13 April 1953

[PAGE 145]
This is to certify that I have\_today received Cashier's check No. M138335 of the in the amount of \$102.67.

March 2, 1954

This is to certify that I have today received Ceshier's check No. M138334 of the W w, in the amount of \$2,566.67.

[PAGE 146]
I hereby acknowledge receipt of the following: CHECK#HBN IN THE AMOUNT OF S2SG6 RECEIVEO.

CHECK# H138335 IN THE AMOUNT OE S/267 RECEIVED.

SIGNATURE OF RECIPIENT 18Feb54 DATE RECEIVED

[PAGE 147]
ISWORANDUH FOR CRIEP, FINARCE DIVISIOR

Invoiee No. 1, Subprojest 22, Project IXULRA

1.Invoice No. 1 for Subproject 22, Projeot MULIA 1s attached. It ip reqvestei that payieent ba pade by tvo caahier's checks wodle out to the order of Ceuuaas in tho acounto of C \$2,566.67 and \$102.67.

2. Tho chocka ohovld to sont to Coief, CD/Tss throuch 2as/Bulget ofcicer by h Fobruary 19sh.

BIPNBY GOPILIEB Chief Chenical Division, TSS

Attachaonter Invoico Cortificetions

Mstributiont Addresaco - Orig. & 2 Comotroller - 1 Exa. Cec'y., Ees. l.l Tas/bulget \~1 TS3/Begistry= 1 T83/c0 - 2

IN THE AMOUNT OF \$SEG RECEIVED. …

FEB 1 8 ENTD

H

CHECK#H139335 IN THE AMOUNT OF \$/2G7 RECEIVED

FEB 18 ENTO

[PAGE 149]
(1) "zt ie bereby cortiried that thie 1o Iavolca No. 1 applying to subprojost 22 or Project Jaulna, that technical porfonaance by hos beau satisfcatory, that tho vork is being sccauplished ia occordaneo vith the matual agrcoaent reached vith @mm 4eh that this bill io just aod correct and that popzent tboreor haa pot yet been mais.

SIDEY GOTTLIED Chier, CD/rS3\*

(2) "It ia hereby certified that thia invoico epplies to aubproject 22 unlor Project MuLt vhioh vas duly approvat and that the project is toing cerried cut in scccrlanco vith the Do/p momoroniua to tcí dated 3 Apri1 1953, the DCI memorandu to p0/A dated 13 April 1953, and the DCI mwaoronlus to the DD/A dated 19 Jubo 1953.

(3) "It is heroby certified that the scopo of tho progrua or sabproject 22 of Projeot NuLTRA hao been approved.

I CERTIFY THAT F :DS ARE AVAILABLE: O6

[PAGE 150]
Under the outhority granted in the pecorandua datel 13 April 1953 from the DCI to the DD/a, and the further authority granted in the memorandua datei 17 April 1953 from the DD/A to the Comptroller on the subject, "DD/P-TSS Project MXULTRA," and the nemoranáus datei 19 June 1953, fraa the DCI to the DD/A extending the authority to cover Fiseal Year 195h, Subprojeet 22 bas been epproved, and \$8,008.00 of the over-all Project MULTRA fuds have been obligsted to cover the subproject's expenses.

PROGRAN APPROVED AND RECONCENDEDI

Chief Chenical Diviaicu, TSS

APPROVED FOR OBLIGATION OF FUNDS:

Distribution: Addressee - Orig. & 2 Exec. Sec'y,, Res. Bd. - 1 TSS/bulget.-1 TSS/Regiatry - 1 Tss/cD - 2

[PAGE 151]
Downeraded to: CONFDENHAL by authorityof: 187475 cate: Juno 1977

E2 IMPDET; CL BY 187475

MEMORANDUM FOR THE RECORD:

SUBJECT:

Project MULTRA, Subproject 22

1.  Subproject 22 is a continuation of Subproject 1 which had as its scope preliminary work on the isolation and characterization of the alkaloids of Impoinea sidafolia Chcisy (Rivea corym bosa) in orier to'deternine their sctivities as agents afrecting the central nervous system.

2. The results of the-pretiminary study ere such that a full progran of research on this material is desirable. Dr. C who conducted the preliminary work, has submitted the attachel proposal to carry out this work as outlined by CD/TSs.

3. The .yill serve as cut-out for transfer of funds to the invesvigator. The estimated cost of the work according to the proposal is \$7,700.0o for one year. To this must be added hd service charge for the amount - ing to \$308.00. The total cost of this investigation for a period of one yeer, therefore, wi11 not\_ exceed-\$8,008.00.

4.Drhas been granted a Top Secret Agency clearance and is fully capeble of protecting the Covernment's interest in this project.

Chemica1 Division, TSS

APPROVED:

Downgradod to: CONHULAIIAL by authority of: l37475 Cato: June 1977

PROGRAM AFPROVED AND RECOMENDED:

Chief, Chenical Division, TSS

APPROVED FOR OBLIGATION OF FUNDS:

Research Director Date: 28a\~1954.

[PAGE 152]
I am aware of the interest your Foundation has in supporting research related to physiologically active compounds. Recently I became-interested in determining what is the active component(s) of the drug "piule". My wo rk together with the meager technical literature available on the subject convinces me that financial support will be necossary before I will-be able to continue the investigation. I am, therefore, submitting to youa summary of the work completed on the problem to date, together with an estimate of-the-funds that will be needed to purchase equipment and supplies and-to employ help.

University officials-are aware of this request. If you see fit to support this research, I plan to employ one or two graduate students-who will work part time on the problem while. working toward the M.S. or Ph.D. degree. My work in the field of plant alkaloids dates back to l948. Most of this work was carried out at the University of When I moved to University in the fall of 1953, I found that no work in this-field had been carried out here; As-a result, very-little of the necessary equipment is available. Departmental funds are available for some, but not all,of-the necessary equipment and supplies. The funds requested for the first year of the investigation,"therefore, include these.

SENSITIVE INTELLIGENCE SOURCES AND MÉTHODS INVOLVED

WARNING NOTICE

[PAGE 153]
The seed ofa trailing vine which grows in Mexico and Central America has been used-by natives-of those regions since Ancient times as a narcotic. Although the plant has been classified by taxonomists-of the Smithsonian Institute as Impomoea sidaefolia Choisy, a plant of the Convolvulaceae

family, its seeds,because-of their-physiological activity have been considered as one of the "peyotes". The most comon example-of a "peyote" drug is the button from the cactus, Anhlonium lewinii

Until the work reported here, the only work carried out to determine the active constituents) of these seeds was taat by C. G. Santesson of the Medico-Surgical. Institute in Stockholm and reported in-the Archiv der Pharmozie 275 532-537,(1937). His experiments, which were conducted on small quantities of seed, indicate that a water extract of the crushed seed contained a glyco-alkaloid which had narcotic effect on frogs, mice and rabbits bofore and after acidic hydrolysis. The presence of sugars was determined by means of the Fehlings test. The evidence for reporting alkalo was precipitates with reagents such as phosphomolybdic and phosphotungstic acids.

In thepresent investigation, which was.carried cut during a five week period at the

WARNING NOTICE

[PAGE 154]
repeat the work of Santesson and determine the best means of extracting the aotive constituent(s). Finally a l00 g. sample of the seed, crushed to pass a 15 mesh sieve, was extracted in a sohxlot with petroleum ether to remove oils The de-oiled seed was maxcerated with distilled water and the mixture centrifuged to separate the marc. This marc apparently was devoid of alkaloid or glycosides extractable with various polar and non-polar organic solvents. The aqueous extract was freed from most protein material by the use of trichloroacetic- acid.The deproteinated-extract

was neutralized by means of ion exchange resins. The effluent from the resin column was concentrated-in vacuo resulting in the precipitation of more gummy material. The supernatant was-clear, véscous, dark green-and intensely bitter It contained no free reducing sugars. Tests with alkaloidal reagents were inconclusive. Attempts to extract alkaloidal material from this solution using various solvents were unsuccessful.Emulsions-interfered with the extraction in both neutral and basic solution. The aqueous solution was stirred with methanol, a procedure which removed most of the polysaccharides, which were presept in large quantities and decreased the viscosity of the aqueous solution. The resulting aqueous-alcoholic solution was concentrated to remove methanol. It gave positive tests with all common alkaloidal reagents and negative tests for reducing sugars.

WARNING NOTICE

[PAGE 155]
A minute quantity of crystalline material, formed in this aqueous solution after a day. This material has not been identified. The remainder of the solution was evaporated on a water bath, in a nitrogen atmosphere without obtaining additional crystalline material.The residue was taken up in water and more polysaccharides precipitated-with the addition of methanol. Repeating this procedure eventually removed all of: the polysaccharides. From the supernatent, after removal of polysaccharides, no crystalline material was obtained. Tests on this solution indicated the presence of alkaloids and the absence of reducing sugars. This solution also was intensely bitter, a crude indication of the presence-of the active principle(s)-of "piule" No test animals were available at the time for physiological. testsof various fractions. This solution was hydrolyzed with 2N HgSO4. A voluminous amount of precipitate resulted.The clear-supornatant yielded excellent tests for alkaloids and reducing sugars. Paper chromatography was employed to confirm the presence of reducing sugars. The polysaccharides were hydrolyzed and the resulting solution, after neutralization, was subjected to paper chromatography. The results areincomplete: however, glucose, mannose and xylose appear to be the predominaté monosaccharides prese:

WARNING ÑOTICE NOTICE

[PAGE 156]
Futuro plans call for the following.

The use of larger quantities or the seed. (Originally oniy a-small quantity was available, now there is a large quantity available.)

Considerable work on the use of ion exchange resins in order that this technique can be used on aqueous extracts of piule without the possibility of losing some of the active principles.

Work to be-continued\_on the\_isolation\_of glycoalkaloid(s). There-is-some-indicationin this investigation that in addition-to one or more glycoalkaloids there is also uncombined:alkaloid.

Work to be continued on the identification of the sugars combined-in-glycoalkaloid moieties; Test animals to be used to determine the presence of the active principle(s) in various fractions.

When the glycoalkaloid(s) or/and-alkaloid(s) have been isolated work will be undertaken to deternine their physiological activity on laboratory test animals, their physical and chemical properties including ultraviolet and-infrared spectra.

If the alkaloid(s) cannot-be-identified as known alkaloid(s).. work will be instituted to.elucidate thestructure.

It is estimated that this investigation will require

from three to five years to complete.

WARNING NOTICE

SENSITIVE INTSLLICENCE

[PAGE 157]
(includes special equipment such as Beckman DU spectrophotometer, centrifuge, sohxlet extractor, paper chromatography equipment Kofler hot stage and smali mill for grinding seed.). ..82700

Analyses and tests 200
Salary (senior investigator) ..1600
Salary (graduate-assistant, 1l mo.)............l800

\$7000 plus overhead 700

WARNING NOTICE

SENSITIVE INTELLIGENCE SOUDCESANOWTUODC INVOLED

[PAGE 159]
Uaiar tho authority granted In the mmorenäuna dsted 13 April 1953 fros the DoI to tho Do/4, eni the further autborlty granted in the merorandua datod 17 April 1953 froa the Do/A to the Casp. troller oo the subjeat, po/e-Tss Project kRuA," and the omorcalus dated 19 Juno 1953, fros the DCt to the Do/A exterdins the sathority to cover Fiscal Tear 19sh, Sutprojeet 22 bas toen approvo1, ani 8,008.00 of the over-all Projeot MULTRA Aunde heve bean ohlisated to cover tho subprojoct's oxpanaos.

POORU APPROVED AND RECOSONDRDI

SIDNEY COPTLIES chior Chenicel Divioion, T39 APPROVED FOR OBLIQATION CP FUDS:!

Distritutioat Aidressee - Orig. & 2 Exec. See'y, Rot. Bi..1 Vss/2ulcot- 1 3/Registry- 1 t/cD- 2

[PAGE 160]
Reference is made to our memorandum dated 29 May 1953, requesting a covert security clearance-to-perait TSS\_to utiliza the Subjectts personal knowledge in.connection with.ahighly. sensitive-research problem incident to\_Project MKULTRA.\_The. Subject will have access to TOP SECRET Information.

2. In'accordance with the provisions set forth in the Director's Memorandum of 14 Februery 1949. entitled "Security and Operational Clearances", a covert security clearance is granted for the covert use of the Subject as described in your request as set forth in Paragraph 1, above.

2 3,: The Subject is not to represent himself as, nor is he-to be represented as, an employee of-CIA

Your attention is called to the fact that a covert security clearance-does not constitute complete compliance with the provisions of CIA Pegulation  Therefore, if you shculd desire at.a later date to change the status or use of this individual, a request for clearance to cover any proposed change should be subnitted to this office.

5.: This clearance becomes invalid in the event the Subiect's services are not utilized-within 60\_days of-the date of.this memoranduù,

C Haison & Security Offrcer DD/P/TSS

/alb (14 September 1953)

SO 2-1266 14 September 1953

[PAGE 163]
MEMORANDUM FOR: THE RECORD

SUBJECT : Schedule of Grant Payments MKULTRA 22

November 1961 to November 1962

TOTAL GRANT\$15,410.00

22 November 1961

[PAGE 164]
MEMORANDUM FOR: THE RECORD

SUBJECT : Schedule \_of Grant Payments MKULTRA 22

November 1959 to 0ctober 1960.

Due Nov 1, 1959 2891.75
Due Feb 1, 1960 2891.75
Due May 1, 1960 2891.75
Due Aug 1, 1960 2891.75

TOTAL GRANT 11,567.00

7 October 1959

[PAGE 165]
Date Initlated: 28 January 1954

Date Expirea: Continuing

Purpose: Isolation and Investigation of the active principals of certain botanicale of interest.

Status: Final fractions aro beíng studied on the Rivea corymbosa separation, considerable progreas has been made oa the separation cf the ective constituents of Amanita muscaria, and a start bas been made on the separatlon of Rhynchosia

[PAGE 166]
STS

[PAGE 167]
A,B, C, A

From: principal investigator

Re: Final financial accounting for renewal of research grant entitled

Period of grant: Noyember 1, 1962-- July.15, 1963

For professional services rendered in research \$4500. and
Travel expenses return by auto and plane 1115.
Living expenses at 1950.
Laboratory fee at 140.

Total expenditures \$7705. Total funds from grant 7705. Balance -0-

This is a correct accounting of funds received by me as

April 17, 1964

[PAGE 169]
May 1, 1963

Incorpcrated

B.C

Your check for \$2,575.00, -representing the third quarterly payment, for research work, was received today. Thank you for taking care of this matter for us.

Very truly yours,

#22 32.8

OFFICE OF RESEARCH ADMINISTRATION

[PAGE 170]
22

22 Apr11 1963

[PAGE 171]
.14,1962一

Dear

adached or two copuer of accousting onr the qrant funds at sil Shecked this and all appeor t he se ordes. of shere are avy querbeone fust let meknow.

Cordially

[PAGE 172]
I certify that the above statement-of-accouut is correct to the best of my knowledge.

Business Manager

I have examinej and approved the suomitted expenditures.

TSD/BiologicaI Branch

[PAGE 173]
22.12

6 August 1962 A, B, C

MEMORANDUM FOR THE RECORD

SUBJECT

Authorization was given this date to

rant time until 1 August 1963

[PAGE 174]
Support of Research on

1: This date discussed in detail the status of our research on the physiologically active principles of the mushroom with the principal investigator on this project. has made outstanding progress in his laboratories in The research has progressed to the point where it is important to engage in more detailed phases.

2. In discussing the projected research, said that he was unable to engage in certain criticalphases due to lack of contact with certain types of apparatus. He was of the opinion that it was most important to bring into the research picture an outstanding research worker who was knowledgeable in the field of drugs natural products.

3. Following consultation with discussions were held between and myself. It was the consensus that this work coul est be undertaken in the laboratories of was in complete agreement with this since it would permit him to devote full time to his rosearch and at the same time, óbtain much needed information on researches first hand.

4. pointed out, however, that he would be unable to carryout such.a.program without additiónal support. He stated that he had been in correspondence with and had received several cordial invitations to work.in laboratories, pointed out that his expensos would be in excess of \$l0,000, owing to the. fact that hewould have his family to transport and take care of. He was advised that the grant could not undertake support .to this extent, but that it would.be possibe to use about 1 of the existing grant to reimburse him for his professional services, transportation, and a portionof his living expenscs while in residence at He was informed that. he, personally, would have to make his own arrangements about the additional funds roquired. stated that this was quite agreeable to him and that he would take the necessary steps.

26 March 1962

22.13 AB,C

MEMORANDUM FOR THE RECORD

[PAGE 175]
2

[PAGE 176]
4 Report of Expenditures November 1, 1960 to November 10, 1961,

Expenditurest

Overhead @ 15% direct costs

Total Expenditures.

Balance

I certify that the above statement of account is correct to the best of my knowledge

[PAGE 179]
1. Invoice No. 11 1u tha aaount of \$16,026.40 covering the above subproject is attached.: Payment shculd be mads as follova:

2. The checks should be forvarded to Chief, Tsp/Research Branch, through Tso/Budget Ofricer, no later then 3 Novimber 1961. Thia is a final invoice. Hosever, eince it is aaticipated that cdditional funde vill ts obligated for this project, the files should not.be olosed.

Chief T8D/Regearch Branch

RECEIVED.

[PAGE 180]
Iavoica No. 11 La the ssount of \$16,C26.40 coveriog the above subproject ls attacbed.Psysent ahould be aade aa follcvs:

The checka shoula to forvarded to Chier, ToD/Sesearch Broaeh, throueh TSD/Bsdget Officer, no later then 3 Noveaber 1961. 3.. Tiis is a final involco, Hcvover, sinco it.is enticipated that saditional funde vill be obligated for thia project, tho filea should not be closod.

Attacheent: Invoico & Certifications
Diatributiont Orig 4 2 - Addressce

Chief TSD/Research Braoch

18 .OCT
CERTIFY TRAT FUNDS ARE AVAILABLE 1961
CSUGATION RSFORRIO NO 632
CHARGE TO A NDS N AUTHORZING OIIKER

[PAGE 181]
tt

[PAGE 182]
CERTIFICATIONS

11) it is bereby certifed that this is Invcice 11 appiing to Sub-project No, 22ef MKULTRA, that pericrmence is sadsfattory. that servless are being accomplished in accerdance with mutuai agreements, that a detailed agenda of the payments snd receipts is en file in TSD/RB, that this bil is just and correct and that payment thereof has not yet been made.

Date:

22 (2)It ix herebv certlfed that this invciee applies to Subproject of MKULTRA wbich wag duly appreved, and that the project is being -carried out io secordance with the-memorandaér cf 13 April 1953 from the DCI to the and the extenaion of thie authority lo subaequent memoranda.

For Servicea

INVOICE

\$16,026.40

Research Directer

[PAGE 183]
Cost Account oe

Object Class

一

[PAGE 184]
MEMOBANDUM FORI COMPTROLLER ATTENTION Finance Division

Project MKULTRA, Subproject 22 Additional Authorlzalion f9

Under the authority granted In the Memorandum dated 13 Aprll 1953 from the DCI to tho and the extension of thís autbority In subsequent memoranda, Subproject 2Z has been approved, and \$16, 026.40 of the over-oll project MKULTRA

fands has been obligated to cover the subproject's expenses and should be charged to Allotment 2123-1390-3902

APPROVED FOR OBLIGATION OF FUNDS:

Chief, TSD/Research Branch

Distrlbutlop: Orig & 2 Addressee 17 TSD/OC -TSD/FASS 2-TSD/RB

AUTHORZING CRAICE

27 September 1901

[PAGE 185]
MEMORANDUM FOR: THE RECORD

A,B,C

SUBJECT : Project MKULTRA, Subproject #22

1. The purpose of this Subproject is to provide funds to continue

-the researches of Prof. on the isolation of compounds

-from natural products which bave psychogenic properties. Prof.

is concentrating his studies on isolation and identification of active

materials in the fungus Amanita muscaria.Studies will be extended

to active principles in Rhynchosia phaseoloides.

-2. Progress in the studies of Amanita has been significant to

date. It is believed that the chemical entity primarily responsible

for the hallucinogenic effects of Amanita muscaria has been isolated.

Because of the extremely small amount in the fungus, and due to the

lack of sufficlent quantities of plant materlal the amount isolated has

been insufficient for complete structure elucidation. Effort during

the coming year will be directed to obtaining adequate supplies of

fresh material and the carrying out of various extraction and concen-

tration procedures. Chemical and biological techniques will be

utilized to Identify and characterize the active principles which are

of interest to TSD.

一

J2.22

27 September 1961

[PAGE 186]
3 for transfer of funds to the investigator. The estimated cost as outlined In the budget proposal is \$15, 410.00. To this must be added the 4% service charge to the cutout, making the total cost for one (1) year not in excess of \$16,026.40. Charges should be made against allotment.2125-1390-3902.

4.A Memorandum of Agreement has been signed by the contractor whereby title to permanent equipment is retained by the in lieu of higher overhead charges and arrangements are made for accounting for funds disbursed under the grant.

5. It has been mutually agreed that documentation and accounting for travel expenses under the grant which are reimbursable by the shall conform with the accepted practices of that instItution. 6. Prof.holds a covert clearance under Project MKULTRA 6. Prof.holds a covert clearance under Project MKULTRA and has agreed to comply with the terms of the Memorandum of

Agreement.

APPROVED FOR OBLIGATION OF FUNDS:

Research Director 11331

Date:

Attached: Budget

Distribution: Orig. only

[PAGE 187]
Investigation of. the Fhysiologically Active Principles of Amanita Muscaria end Other Plants of Potential Medicinal Value

RENEWAL OF A RESEARCH GRANT

[PAGE 188]
Post Doctorate (12 mo.) Director's stipend (3 mo.) Student help

Meetings and travel in connection with work

September, 1962

Sample collection and preparation ---

1,000 pounds of Aranita Muscaria at \$2.00/1b., etc. \$2,500

Analyses, literature and special chemicals, etc. -- \$ 500

Equipment .-

Uninelt Meiting Point Apparatus--- Rotary Molecular Still, Ozone.Meter\_

\$13,400
2,010
\$15,410

BUDGET PROPOSAL-1961-62

Salaries and wages --

Overhead 15%

\$6,000 1,500 500

[PAGE 189]
We are pleased to be able to tranamit to you the following

These funda represent a contribution for the uee of your directors in carrying out the very worthvhile reeearch goala of your organization.

[PAGE 190]
1. Invoice No. 10 in the anount of \$9,645.38 covering the above subproject is attached. Hovever, due to refunde of \$é65,43 froa thia project (as per attachuent) payment should be made as follons:

Caahier's check in the amount of \$8,634.57, drawn
on a ptoonmes benk
Caahier's check in the amcunt of \$3h5.38, drawm
on a dhsa bank. 979.9

2. The checka should be forwarded to Chief, TSD/Rescarch Branch. through TSD/Budgat Ofricer, no later then Wedneeday, 7 Deceaber 1960. a..This is a final invoice. Hovever. since it is anticipated that elaitional funds vill be obligated for this project, the files sbould not be closed.

Attachocnt: Invoice & Certirications

Distributiont Orkg & 2 - Addresses E 1 - TSD/FASS

OKCANSr. 981
C1011125-1390-3902

29 Noveaber 1960

[PAGE 192]
For Services

\$8,979.95
\$9,672.00

CERTIFICATIONS

(1) It 1s hereby certified that this 1a Invoice No. l0 applying to Subproject 22 of MOLTRA, that performance is satisfactory, that services are being accoaplished in accordance with mutual agreements, that a detailed agenda of the payments and receipta is filed in TSD/ RB, that this bill ia just and correct and that payment thereof has not yet been made.

Chief, TSD/Research Branch

Date:

(2) It is hereby certified that this invoice applies to Subproject 22 under MaLTRA which was duly approved and that the project 1s being carried cut in accordance with the memorandua dated 13 April 1953 froa the DCI to the DD/A, and the extension of thia authority in subsequent pecoranda.

Date!

INVOICE

Research Director

[PAGE 193]
(3) It 1s bereby certified that Under, subproject 22 at the close of FY59 a balance of \$665.43 representing uused funds remained in subproject 22. Additional funds ( FY 1125-1009-1902) have been approved for continuing subproject 22. Therefore, it is raquested that \$665.43 of Invoice No. i0 be credited. subproject 22 as a return or unused funds (FY 9-2502-75-902), MOR 2707.

Chief, TSD/Research Branch

Research Director

[PAGE 194]
Cost Account1122. /009-1902

Object Class

[PAGE 195]
15 November 1960

MEMORANDUM FOR:COMPTROLLER

ATTENTION :Finance Divislon

SUBJECT

: Project MKULTRA, Subproject 22 Additional Authorlzatlon \$8

Under the authority granted in the Memorandum dated

13 April 1953 from the DCI to the DD/A, and the extension of

this authority in subsequent memoranda,.Subproject 22 has

bees approved, and \$9, 672.00 of the over-all. project MKULTRA

funda has been obligated to cover the aubproject's expenses

and should be charged to Allotment 1125-1009-1902.

APPROVED FOR OBLIGATION

OF FUNDS:

Rceearch Director

Date:\_

Diatribution:

Orig. & 2 - Addresgee

1-TSD/OC A-TSD/FASS 2-TSD/RB

19 981 TSD/Rosearch Branch

TSD/(15 Nov.160)

[PAGE 196]
MEMORANDUM FOR: THERECORD

SUBJECT : Proiect MKULTRA, Subproject #22

1. The purpose of this Subproject is to provide funds

to continue the research of Prof. Ton the C

isolation of compounds having psychogenic and related prop-

erties from natural products. Prof. is concentrating his

studies on Rivea Corymbosa  variety and Amanita

Muscaria and has-isolated some active materials which are:

2.Difficulties in obtaining properly documented\_raw

materials in sufficient quantity for further research have been

to a large extent overcome,Considerable renewed interest

on the part of several drug companies of foreign origin in

related fungi and plant materials believed to have central

nervous system activity indicate that there may be chemical

compounds in the natural products under study of considerable

serve as cutout for transfer of funds to the investigator. The

15 November 1960

22-32

[PAGE 197]
eatimated cost for the coming year of the work is \$9,300.00. To this must be added the 4% service charge to the cutout, thus the total cost for onè year will not exceed \$9, 672. 00. Charges should be made against allotment 1125-1009-1902.

4. A Memorandum of Agreement has been signed by the contractor whereby.title\_to.permanent equipment is retained by the University in-lieu of higher overhead charges and arrangements are made for accounting for funds disbursed under the

5. It has.been mutually agreed that documentation and accounting for travel expenses under the grant which are reimbursable by the University shall conform with the accepted

practices of that institution.

6. Prof. holds a covert clearance under Project

MKULTRA and has agreed to comply with the terms of the

Memorandum of Agreement.

APPROVED FOR OBLIGATION OF FUNDS:

Date: 18/60

Attached: Budget Distribution: Original only nal on1

[PAGE 198]
BUDGET 1961

[PAGE 199]
for renewal of suoport to investigate

The Physiologically Active Principals of Amenita Muscaria.and.. Rivea Corymbosa

Principal Investigator

[PAGE 200]
PROGRESS REPORT

for

Grant Fiscal Year 1959-60

During this year work has progressed to the point where crystal
line substances with physiological action have been isolated from
Rivea Corymbosa and Amanita Muscaria. Rather than review all the
work in detail two papers are attached which describe the principle
aspects of the investigation during the year. The first of these
is. a paper which has been submitted for publication in regarding Rivea Corymbosa.The second is an adoption of
paper regarding Amanita Muscaria which was presented before the August 15-25, 1960.

g2-34

[PAGE 211]
Research Plans for 1960-61.

As irdicated in the accompanying progress reports and papers related to the research-supported by the grant, several crystalline substance have been isolated from Amanita Muscaria and Rivea Coryubosa Future work will be organized to accomplish the following objectives:

1. Ascertain, by means of biological testing, which, if any, of the crystalline materials exhibit significant physiological effects in test animals. (This work is being carried out under the supervision of Dr at the

2. Complete fractionation and purification of crude concentrates which exhibit physiological effects in test animals.. When pure crystalline substances are isolated they will-be identified or structural elucidation will be attempted.

3. For those.substances,which-exhibit-significant physiologicel effects and which have novel structure, an attempt will be. made to synthesize them and compounds with related structure in order that-relative physiological activity can be determined.

At the recent it was revealed that Dr. Rof has isolated three indolic compounds relateu to Lysergic-acid froa Rivea Corymbosa. Also it was learned by private conversation that research teams of several of the countries leading drug firms-have isolated flavanoid glycosides from Rivea Coryubosa. The structures have not been determined nor has work been published other than that by end in (1960). As a result of these developments less emcdasis wil de directed toward continuation of this investigation. Dr who as a pre-doctoral graduate student worked on this proolem, is now located at and plans-to complete structural elucidation of the glycosrde Isolated in our laboratory from Rivea Corymbosa. If it is possible to obtain a sizable quantity of Rivea Corymbosa from an area inpme where the plant is used for medicinal or occult purposes, then it is proposed that the sample be carefully investigated to ascertain if it contains indolic compounds or glycosides significantly different from the samples collected in areas where the plant is not utilized for its physiolcgical action.

37 26

[PAGE 212]
PROPOSED BUDGET FOR FISCAL YEAR 1960-61
November 1; 1960 - 0ctober 31, 1961

Research Fellowship (a) \$200 per month ------------- \$2400

Miscellaneous student help (a) \$1.50/br. (400 brs.)  600

Stipend for senior investigator (during summer)-----1500

Special chenicals, naturat product samples, end 500 supplies (expendable)

Special analyses on research samples 350

Travel and communication in connection with project ----600

Special books, reprints, manuscript and slide preparation and trenslations related to project - 150

Capital Items:

1. Ozone meter for ozonolysis-apparatus which \_we have--- -100

2. Matching funds for photoelectric attachment for Model No. 80 Rudolph Polarimeter.------500

Components (sweep-unit,-coils-and-probe) to adapt our NR for fine line work in connection with project--------- 1400

Indirect costs (15% of request) 1200/215

Total request in renewal of grant ------- \$9300

Signed/

2238

[PAGE 213]
Roport of Expeodstures Soveber 1, 1959- 0ctober 31, 1960

DuD8 6795-75 OLOLIRUI

111,037.00

Exreoiituresu

Selarics snd Vacne (incluiing Pellovshipo). \$5,909.00 1.000.79
Buppltes and Exqmpoca 2,197.00
Equinxont 1.45b.78
Overicod Total Expenlitures

20,801.57

Belanco as os Ootober 31, 1960

6669.43

I have examined and approved the sutaitted expenditures,

I certisy that tho ebove stetarent of account io corrcotat B

paton 1/%

IiE/Chezioal Division

Buginese Hanecer

[PAGE 214]
Report of Eqenditures Novenber 1, 1959- 0ctober 31, 1960

Pund 6795-76 CLOLIUQUI

\$11,067.00

Expenditures:

Salaries and Wages (including Fellovahipe) \$5,909,00
Supplies and Epenses 1,840.79
Equipoent 1,197.00
Overhead 1,454.78
Total Ependitures

10,401.57

Balance as of 0ctober 31, 1960

\$665.43

I certify that the above statement of

Business Manager

BUSINESS OFFICE

[PAGE 215]
Report of Expenditures Bovenber 1, 1959 - October 31, 1960

nnd 6795-76 CLOLIUQUI

21,07.0/

Expeoditures:

Salaries end Wageo (including Fellovehiis) \$5,909.00
Supplieo aná Expeneea 1,840.79
Bouipnent 1,197.00
Overbead 1,454.78
Total Epenlitures

10,h02.57

Balance an of 0ctober 3, 1960

\$665.43

I certify thet tho above stetement of eccount 1a correct.vrasa.

I have exisined and approved tho oubaitted exDenditurcs.

A

Daton 2.4 Wacek1 961

[PAGE 216]
Attached are tvo copies of an application for reneval of the grant vhich pow supports a research project under my supervision. An account of funde for the past year wili be supplied by our fiscal office at the end of the month. If thore ie edditional information vhich you desire, I vill be happy to try and supply it. I would like to expreas sy appreciation for your support which is meking possible the reaearch reported in the attached application.

[PAGE 219]
SUBJECT : Action on MKULTRA Audit Exceptions -- TSS/CD

SP#22

A. \$1,703.57 was used for SP/51 per memo dated 21 August 1959. R \$1,487.50 being held inwill be utilized on another project in the near future.

Chief TSS/Chemical Division

27 January 1960

MEMORANDUM FOR: THE RECORD

[PAGE 221]
Report of Eppenditures July 1 to October 31, 1959

Pund 6795-76 OLOLIUQUI:

Overdraft, June 30, 1959 B \$ (185.32) Income: 5,365.00 \$5,179.68

Rxpenditures

Salaries & Wages(including fellovships) \$1,960.00 Supplies and Expenses 334.24 Equipment 1,294.63- Overhead 1,590.81

5,179.68

Balance, October 31, 1959

I have exanined and approved the.submitted expenditures.

TSS/Chemical Division

[PAGE 222]
Enclosed is the financial report as prepared by our treasurer on the grant which your organization made to Dr. The réport covers the full period from November, 1957, to June 30, 1959,We will be happy to furnish further itemizing should you so require.

I am happy to report\_that .considerable progress is being made 0 on this rather difficult-project.Dr. has two very
promising doctoral candidates assigned-to-the problem.They are devoting a-great deal of-time and concentrated effort to B this investigation. We are grateful to the
for the fine support this organizal
has given us for this particular investigation.

July 30, 1959

[PAGE 223]
Period-of Report
November 12, 1957 to June 30, 1959

Fund 6795-76 OLOLIUQUI:

Expenditures

Salaries and Wages Supplies and Expenses Equipment Total Expenditures

Overdraft, June 30, 1959

\$21,684.00

\$7,141.73
1,418.38
13,309.21

\$185.32

I have examined and approved the submitted expenditures..

Date.u

[PAGE 224]
These funds represent a contribution for the uae of your directors in carrying out the very worthwhile research goals of your.organisatioo.

[PAGE 225]
Cost Account.£-2002-75.702

Object Class.

JJ-49

[PAGE 227]
Tho checks should be forwarded to Chlel, TSS/Chomical Divlsloa, through TSS/Budgot Olficer, ao later than 4 September 1959. Thie le a lnal Involce. However, since it le anticipated that additicaal funds will bo obligated for this project, the flles should not be closed.

[PAGE 228]
CERTIFICATIONS

(1) It is horeby certified that thls is Iavolce No. 9 applying to MKULTRA Subproject 22, that performance is satlafactoryi that the services are being accomplished ln accordaace with mutual agreements, that a detalled agenda cf the paymenta and receipte is on file In TSS/CD, that the bill ia juat and correct and that paymeat thereof bae not yot been made.

Chief, TSS/Chemical Division

(2) It le bereby cortifled that this lavolce appllea to MKULTRA Subproject 22, which was daly approved, and that the project is belng carried out in accordance with the memorandum dated 13 April 1953, from the DCI to the DD/A, and the extenslon of thie authority in subsequent memoranda.

[PAGE 229]
GERTIFICATION

(3) It is horeby certifled that the program under subprojecte 49 and 59 have been natiefactorily comploted and returned unused funds. However subproject 2z, which le etill contiaulng aleo refanded money. Therofore. It ls requested that the amounte aß shown below on Invoice No. 10 of subproject 5i.B be credited to the subprofacta as shown below.

6-2502-10-001
6-2502-10-001
6-2502-10-001

Chiof, TSS/Chemical Division

Research Director

[PAGE 231]
SUBJECT : Project MKULTRA, Subproject 22

1. The purpose of this Subproject is to provide funds to continue the research of Prof onthe isolation of coupounde having psychogenic and related properties froa natural products. is concentrating his studies on Rivea Coryubosa variety and Amanita Muscaria and bas isolated some active materials which are of interest.

2. Difficulties -in obtaining properly documentea rav materials in sufficient quantity for further research have been to a large extent overcome. Considerable reneved interest on the part of several drug companies of foreign origin in related fungi and plant materials believed to have central nervous system activity indicate that there may be chemical compounds in the natural products under TSD stuly of considerable TSS interest.

cutout for transfer of funds to the investigator. The estimated cost 89300
for the coming year of the work is \$ll,567.00. To this must be added
the 4% service charge to the cutout, thus the total cost for one year 9172
wil2 not exceed \$12,029.68.

4. A Memorandum of Agreement has been signed by the contractor whereby title to permanent equipment is retained by the University in lieu of higher overhead charges and arrangements ere made for accounting

for funds disbursed unier the grant. dedisbu

DRAFT 25 June 1959

g2-54

MEMORANDUM FOR: THE RECORD

一

[PAGE 232]
ga-sy

5. It has been mutually agreed that documentation and

accounting for travel expenses under the grant which are reimbursable by the University ahall conform with the accepted practices of that

insititution.

6. Prof holds a covert clearance under Project MKULTRA

and has agreed to comply with the terms of the Memorandum of Agreement.

Chief TSS/Chemical Division T50/Reuunh Bromdr

A

APPROVED FOR OBLIGATION OF FUNDS:

Research

Date:6130159

Attached: Budget

Distribution: Original only

[PAGE 233]
BUDGET FOR 1960

[PAGE 234]
Budget for One Year Renewal of Research Project on Investigation of Amanita

Muscaria and Rivea Corymbosa - Nov. 1, 1959-0ct. 31, 1960

Research Fellowships - two. (a) \$200 per month................. \$4800.00

Senior Investigator - during summer.......................... 1200.00

Capital Equipment--(Electric-desalting apparatus,\_explosion proof homogenizer, vacuostat, spinning paper chromatography apparatus,etc.).............2410.00

Special Chemicals and supplies not ordinarily stocked by Department of Chemistry.. ....850.00

Special analyses on research samples..............................300.00

Travel and telephone in connection with grant ................... 450.00

Miscellaneous - phottocopy, monographs, etc...... 50.00
\$ 10,060.00

15% overhead ............ 1,507.00

Total grant request \$1l,567.00

J7-50

[PAGE 235]
6 Jamary 1959

KNANUN PORI COPTRILJAR

ATTENTICu Finence Divisicu

SEEJECT

Projeet ellTA, Subprojoct 22
Additional Autborization f6

Dodar the authority granted in the Mexorandua dated

13 Apell 1953 troe the DCI to the D/A, and the extension of this

authority in subseqoent nesorenda, Dubproject 22 hes been epproved,

and \$3oh,68 of the over-ell project MULTaa fuuds hae beea

oblisated to cover the subproject's axpenses and ahould bo charged

to A110tmnt 9-2502-75-902.

A

APPROVEO POR CELIGATION OF FURDSI

Chlet Ta8/Chenical Diviaica

A

Hezearch Director

70-

1158 9.2507.75.907

Distribution: Orig à 2 → Addressce

1 - TSS/00

TSS/PASB

1 - TSS/SRB

2  TSS/CD

[PAGE 239]
(1) It ts hereby certiriod that thia is Lavoice No. 8 aprlying to MuLTRA Subproject 22, that performance is satisfectory; that the services are being accoaplished in sccordance vith mutual agreemsnta, that a dotailed agenia of the payoente end receipts is on file in TS8/CD, that the bill is Juet and correct and that payuont thereor bas not yet been made.

Chier, Tss/Chemical Division

(2) It is bereby certified that this invoice applies to MULIRA Bubproject 22, which wae duly approved, and that the project ie being carried out in accordance vith hha veacrandua dated 13 April 1953, frou the DCI to the DD/A, and the extensica of this authority in suheequent menoranda.

[PAGE 240]
MKULTRA Subprojeet 22, Involce No. 8
Allotment 7-2502-10-001

Involce No. d is attached covering the above subproject. Payment should be made as followst Cesbier's check in tho amount of \$158.07, drawn on Cashter's check in the amount of \$3, 966.67, drawa on

2. Please forward the checks to Chief. TSS/Chemical Divisioa through TSS/Budget Olficer by Tuesday, l8 June l957 3. This is a iinal invoice. A total of \$6, 188.00 was obligated under this subproject during F7 57. Howover since it is anticipated that addltional funds wil be obligated for this project. the files should not be cloced.

Chtef TSS/Chemical Division

[PAGE 241]
CERTIFICATIONS

(1) It is hereby certified that this is Invoice No. 6 applying to MKULTRA Subproject 22, that performance has beea satisfactory. that the services have been accompllshed in accordance with mutual agreemeats. that a detalled agenda of the payments and receipts is on flle in TSS/CD. that this blll is just and correct and that payment thereof bas not yet beon made.

Chief. TSS/Chemtcal Diviston

(2) It is hereby certified that this invoice applies to MKULTRA Subproiect 22. which was duly approved, and that the project is being carried out in accordance with the memorandum dated 13 Aprll 1953, frora the DCI to the DD/A. and the extension of this autbority in subsequent memoranda.

Research Director

[PAGE 245]
This is an invoice againet previcnaly obligat.d funds. Daca or. Ch1gation30 October 1958 Pur xoea of Project: Extraction of

[PAGE 246]
MEMORANDUM FOR THE RECORD

SUBJECT : Project MKULTRA, Subproject 22

1。 The purpose of this Subproject is to provide-funds to continue the work of Prof: on the isolation of psychogenic compounds from patural products. Pror.d has beea working on Rivea C Coryubosa and Amanita Muscaria and has been able to isolate a number of interesting materials from these sources.

2. Progress in this field has been somewhat delayed due to difriculties in obtaining properly docuzented raw materiels; however, sources have now been developed which should correct this difriculty and make possible the completion of the project. The recent success of the Swiss Chemists in isolating and elucidating the structure or a new psycho chemical from a fungus indicates the feasibility and the necessity of continuing work of-this type.

3. The will serve as cutout B for transfer of funds to the investigator. The estimated cost of. the work is \$9,867.00. To this must be added the 4% service charge to the cutout, thus the total cost for one year will not exceed \$10,261.68.

4. Prof. has signed the Memorandum of Agreement whereby title to permanent equipment is retained by the University in lieu of higher overhead charges and arrangements are made for accounting for funds disbursed under the grant.

xto:TAL /ausorit:187476 ate June 2 IPDET; CL BY 187475

22-66

DRAFT

23 October 1958

oced to:EHTIL 7 anthort of: 187475 late: Juno 1977

ROTIA

r. CL BY 187475

[PAGE 247]
5. It has been mutually agreed that documentation and accounting

for travel exoenses under the grant which are. reimburesble by the

Upiveraity shall confora vith the accepted practices of that inatitution.

6. Dr. bolds a covert clearance under Project MKULTRA and

bas agreed to couply vith the terms of the Memorandum of Agreement.

Chiof TSS/Chemical Division

Attachment: Budget

APPROVED,FOR OBLIGATION OF\_FUNDS:

Date of. Go 1918.

Diatribution: Orig. only

os-oded to: OEN cuthority of: 137475 ta: June 1977 1

Dounded t: by authority of: 187475 date: June 1977

E2 IZPDET; CL BY 187475

DRAFT

INGDIT; CL BY 187475

-2

[PAGE 248]
BUDGET FOR 1959-60

WARNING NOTICE

SOURCES AND METHODS INVOLVED

[PAGE 249]
Expenditure and chargest. Totel direct charges per prior zoport, 2/28/57 4 202 46 Selazies, 6 mos,@ 150,00 900 00 Travel sxpense, Dr. 30 00 Telephone and telegraph 803 Supplies and Miscalaneous 145

[PAGE 250]
2 November 1957

Dear Mr. d.

This ls to acknowledge the receipt of the following checks ;

Check #G 20251 drawn on the \$16,819,00.

Check #DM 43521 drawn on the for \$672.76.

Your generous contributlone are greatly appreciated, Tbe funds wlll be utilized by our Board of Directors In furthering worthwhile research projects in the fleld of medical sciences.

Yours truly!

Rxecutiye Secretary - Treasurer

[PAGE 251]
Summary of work, November 1, 1955- September 25, 1956:

Physical examination of the soed used in this work roveals that two "typos" have been under. investigation. Taxonomically all the seed have boen called Rivea Coryabosa although one varioty (the sood are the larger or the two varietiee) originated in Nexico and one varioty originated in Cuba. The literature on the subjoct of ololiuqui, as far as I can ascertain indicates that its use as a psychic drug has been-restricted to Mexico. This data alone vould indicate the probability that the Cuban vartoty lacks soze physiologically aotive component'yhich tha exican variety contains. Experimental work/in this lappratory has been largely rostricted to the Cuhan voriety (smali seed sinco only a very aaall amount o tho Noxichn variety has been available. The chemical work, although not desigcd to compare the coapositlon of the teo varieties, hes indicated soze differencg in tho tuo. also physiological tests on humans aro indicatíve of a difference in the tro verieties.ihis work is mch too incbhclusive to be-auch more thon speculation at this time.

In addition to tho Isolatio.. of glucose and hyáro quinone as constituents ot ololiuqui as reported in the last progress report, txo crystalline frections have boen isolated which seen nolther to oe alkaloid or glycoside Due to the small quantity of seed available tho amount of these crystallino fructions is extrenely snnll and little more than qu litstive tests have been mede on thed. Experimontl tochniques, especially in extraotion and soparation have been perfectod which vill be used to isolate pure coponepts oftho drug which,-just today has become ayilable in sufficient quantity to make the investigatiopprofitable. plans for fuhiro investigation:

Now that 50 pounds of the Cuben vorioty and l0 pourds of tho exican variety are avsilable, tho folloving linos of investigation will be actively pursuod.

l. Detemine conolusively if there is a chemical difference in tho twc varietios of seed.

2. ootain ss many "puro" components fron each veriety, using previously perfocted-tochniques, as is possible. -t

3. Subnit for physiologlcsl tosting ouch "rure" component.

4. Subject oach "pure" componont to cheaical oxaminution to doteraino tho tyge of cospound, vhother it is a kown conpound and ita chemical composition if it is 9 ney compound.

Request for renesal of eupport for the project: Investigation of the seed of Rivea Corymbosa(oloiuqui).

[PAGE 252]
Equinment (including larger scale
extraction and separation equipment)
and special chemicala \$1000.00 Analyses and tests 350.00 Travel expenses 500.00 Salaries (one graduate essistant, laborptory
help ard direotorts atipend 4000.00 Miscellanecus 100.00 Total \$5950.00

Proposed budget, November 1, 1956- Novemoer 1, 1957,

[PAGE 253]
MEMORANDUM FOR: CHIEF. FINANCE DIVISION

MKULTRA Subproject 22, Invoice No. 7
Allotmant 8-2502-10-001

1. Invoice f7 covering the above subproject ts attached. Payment should be made as follows:

Caebter'e check in the amcunt of \$16, 819. 00 drawn on E

Caebier's check ln the atnount of \$672.76, drawn on ef

Both checkashould bo made payable to B

2.The checks ehould be forwarded to Acting Chief, TSS/Chemlcal Division, through TSS/Büdget Officer, no later than Friday, 18 October 1957.

3. Thio la a Bnal involce. A total of \$17, 491.76 was obligated under this subproject during FY 58. Howover, aince it Is anticipated that additional funda will be obligated for this project, the fllee abould not bo cloced.

Acting Chlef TSS/Chemical Divielon

Attachments: Invoice & Certiflcationa

Dietribution: Orig k 2 - Addressto 1-Comptroller

16.8155

14 October 1957

[PAGE 254]
(1) It is bereby certified that this le Iavelee No. 7.applying to MKULTRA Sabproiect 22, that perforraance has bsen eatisfactory. that ths services Laxa baca accomaplished in accordanco wita mantual agreemeatsr that a dttalled agends of tha paymcote and recoipts is en file in TSs/CD, that thls bill is just and correct end th at payraent thereof bas not yct boen mide

Acting Chief, TSS/Chepaical Divinion

(2) It is hareby certified that thla iavolce appas to MKULTRA Subproject 22, which was duly epproved, and that the projoct ls beiag carried cat ia eccordance with the memorandumn dated 13 Aprll 1953, from tho DCI to tha DD/A, and the extensioa of tais cuthority in sobacquent mcmoracda

Research Director

[PAGE 257]
13 Age11 1953 froa tho D0I to the D0/A, 6n tha oxtenaion of this enthority in mubeeqont pezoronda, Eaprojeat 22 has tren approved, 603 817,491.76 0c 15a <v22-a11 pvo190t 130778A fun1a baa beon coligated to cover the cabgaojoot'a expencea end should ta charged

Distriboticni Orig & 2 = Aldrescen 2- T8S/0 12-TSS/PASB 1- TS8/SRB 2  TSS/CD