[PAGE 2]
ADDENDUM TO SUBPROJECTS 8 and 10

1. The purpose of this addendum is to set forth the gutual -administrative responsibilities of-the contractor. and sponsor.

2. The above subprojects-represent the research program C of located at the R B Boston, Massachusetts, covering the period of 9 June 1953 through 15 September. 1955.

8 3. The has requested the 2 Hospital to submit to them a-suwary acccunting of monies received from the Fund.Also,they-requested-the return of any unexpended funds received under a grant from the Fund,

4. Title to-any permanent equipment purchased by funds granted tho Hospitel shall-be retained by the Hospital in-lieu of higher overhead rates.

5. It was. mutually agreed that documentation and accounting for travel experses which are reimbursable by the Hospital shall-confora with the accepted practices of that Institution.

6. It was agreed that technical reports reflecting the progress of the research progran shall be submitted at mutually acceptable intervals. 1

Chief TSS/Chemical Division

APPROVED:

8-2

28 July 1955

Distribution: Orig. & 2 - TSS/CD

[PAGE 3]
Rooa 2409- Qtro. Eye

Order sent to W sbouldcontoin the follosing otaterent:"This chonical vill not be usel for ârug purposes or,sold by us for sucà use XXXXXOXXNOTITNG FOLLONS XOOCOXCCOX

[PAGE 4]
CERTIFICATE

March 2, 1954

This is to certify that I have todey received Cashier'a check No. M138328of the in the amount of \$26,333.33.

March 2,1954

Thiāis to certify that I have today received Cesbier'a check No. M38329 of the in the aount of \$526.67.

[PAGE 5]
SUBJECT:

I hereby acknowledge receipt of-the following: CHECK# 4187328 RECEIVED. IN THE AMOUNT OF\$N33

FEB1.8-1954 438329
CHECK
RECEIVED. IN THE AMOUNT-DF \$SNEZ

A 18 Felt

[PAGE 6]
ASNORANNOUI FOR; CIIEP, FLNWCE DIVISION

SUDOT:

Invoiee No. 2, Suproject 8, Projeot ULRA

Drvoico Bo. 2 for Subproject 8 or Projoet lacnta ia et tacbed It ia roquosted that payzant be raão by two checks in C tho cmounts of ç26,333.33 and \$526.67 sndo cut to 860.00 Tha chocks choula bo sont to Chief, co/Tas, through Tos/kuicat Citicor.

SIDAEY COTILIEB Chiet Cheaical-Divisicn, T33

Attacleontor Invoica Corelficaticas

Pistritution: Allrosvee - Orig. & 1 CHECK 8328 TOF 824333.33 Coptroller -1 RECET
G Exeo. cey. 2/s1 FÉB 18 15 2a3/0D - 2

CHECK#IN THE AMOUNT OF S267 RECEIVEO.

5 Fabomry 1954

[PAGE 7]
CCRTIPICATICES

(1) "It is hereby certilied that thie is Imvoico To. 2 applyins to subproicct O of Project latra, that teohnical perfonance by e is satiecactory, that the work is teing cccapliohel in secoplace vith the mitual aaroezent oched vich amythet thio dill is juat cod coroct ani tuat paynens thereor hos not yet tesa mde.

Chier, CO/TSS"

(2) "It ts berety cortifiel that thia invoice apolios to cubprojeat 8 unior Projoet HLT Vaich va culy opprorod acl that the projoct is teing carriel oud in accoriance vich the Do/P tcnorariua to DE dated 3 7prl1-1953 ani-tho p0I rxmortua to 00/A €ated 13 April 1953. Faaent la cutcorizel ant rogacated.

FE 8 Dator

Noscarch Director

(3) "It is kereby certifiél that tho sccpa of the progras of aubprojeet 8 of Project M has ben cproved.

ICERTIFY-THAT FUUDS.APE AVARLASLE:

OUGATONDSRC0242

TO 3250210

AUTHORIEING OFTICER

[PAGE 8]
Payment due for grant to Service charge of 2% for

C O

Inv.#2

700, 1, 1954

[PAGE 9]
August 31, 1953

This is to certify that I have-today recèived thier's check No. 1033785 of the in the amount of 513,166.67.

[PAGE 10]
August 31, 1953

This. is to certify that-today I have received Cashier's check No.M33785of-the in the amount of 263.33.

[PAGE 11]
FROM: Budgat, Office, TSS

.SUBJECT: TwO checks

I hereby acknowledge receipt of the following: Cheok d M33786 in the amount of \$263.33 and chack  M33785 in the amount of \$13,166.67 as payment for invoice # 1, Subproject 8 Projeet MKULTRA.

signod copylies) of this reçoipt Plaase retura

10
FORM NO. 36-66
MAR 1949

GRE OF RECIPIENT RECEIVED

MEMORANDUM RECETPT

TO: C

28 August 1953 DATE

FRAM: Budget Office, TSS

SUBJECT: TwO checks

I hereby acknowledge-receipt-of-the following: Check # M33786-in the amount of \$263.33. and check # M33785 in the anount of \$13,166.67 as payment for invoice # 1, Subproject 8 Proje€t MKULTRA.

Pleass return algand copy(lee) of this recelpt

Shrlry Sotitesl OATZ RECEIVEL

MEMORANDUM RECEIPT

8-9

28 August 1953 DATE

FORM NO.

[PAGE 13]
(1) "It is tereby cortiried that tbia is Invotce Ho. 1 applyins to subproject 8 or Project MUUTRA, trat tochnicol perromance by is catiofactory,that the work is being nccoaplislel in accorianca vith tho mutual egreement reached vithmsmns that this bill is juot ani correct ard that poyront theroos haa not yet been rode.

Date:.

SIDIEX COMLLEB Chior.CD/TSS

(2) "It is horoby certiried that this invoice cpplios to quvproject 8 unier Project MuttRA vhieh wos duly approved and that the projeot 1o boinc carried out in accorlonce vith tho Do/2 maoraniua to DOI dated 3 April 2953 ead tha-D0I momsranlus to Do/A dnted 13 April 1953. Payrent is authorized and requested.

(3) "It 1s boreby certifted that the\_ ccopa of tho program of subproject 8 oP Project NULRA has leen eyproved.

[PAGE 14]
9 Jua 1953.

RORARONFORTCOPTROLLEA

Vinance Divfsion

SU3JOTI

Project HUDERA, Subproject 8

Unler tha authority granted in the pouoraniua datol 13 April 1953 from tho dor to tho-Do/A aol tho further muthority grantad in the seeocoolua dotot 17 aorll 1953 frca the pO/A to tlo Cozptrollor on tho gublect. "po/2-Tos Projeot MXUlaRA", suvproject 0 hoa deen approvo1, ant o 290.00 of the ovor-all Projeot M tuns bave been obligatel to covór tho gubprojent's oxpensea.

STONEY GOPTLISD Chtef Chesical OiviolcnyTSS

PROGPAI AVFROVEDNO WNGDROSDI-

APPROVSD FOR CBLIGATION C7 FUNDGI

mnta.

Date:

Diatrlduciont Aaaroçeçe - Orisi à 2 EWO2. G istry TOS/0D - 2

A

JUN 19 ENT'O

[PAGE 15]
.August 18, 1953

\$13,166.67
B Payment Die for grant to \*263:33
Sorvice Charge of 2%.. TOTAL. 513,430.00

[PAGE 16]
1. Subproject 8 is being set up as a means to continue the/ present work in the general field-of L.S.D. at until 11 September 1954.

2. This project will include-a-continuation of a study of the biochemical, neurophysiologicaly sociological, and clinical:psychiatric aspects of L.S.D., and also a study of L.S.D. antagonists and drugs related to L.S.D. such as L.A.E.A detailed proposal.1s. attached. C The principle investigatorswill continue to be

3. The estimated budget of the project at 3 .1s\$39.500.00. The: awill serve as a B
cut-out and cover for-this project and vill furaish the above funds
to the as a philanthropic grant for B
medical research. A service charge of \$790.00 (2 of the estimated
budget) is to be paid to the for this service. B.

4. Thus the-total charges for:this project will not.exceed .\$40,290.00 for a poriod ending September 11, 1954.

(pirector of the 5.
hospital) are cleared through TOP SECRET and are avare of the true
purpose of the project. ho Jittls

Chemical Division/TSS

APPROVED:

hdny Sotils Chief, Chemical Division/TSS

SUBJECT:

8-13

DRAFT-ZO4 9 June 1953

MEMORANDUM FOR TRE RECORD

Project MKULTRA, Subproject 8

[PAGE 17]
PROGRAM APPROVED AND RECOMMENDED:

Date:

Attachment: Proposal,

Original Only.

APPROVED FOR OBLIGATION OF FUNDS:

Date: June 16. 1953.

.2.

[PAGE 18]
PA. CTUS FOR COFTIHUATION OF RESLK PROJECT III CS-L.S.D. • d-LYSEROIC ACID DIETHYLAHIDE TARTRATE.

To includo Study of/L.S.D. Antogoniata and Roleted Drugs Such aa L.A.E...Lyaergic Acid Ethylaaide.

The prospectuo for nezt year is in general a continuation of the L.S.D. project along similar lines ta that of this year. :Each aspect of the project (biochexical, neurophysiological, sociological, clinical psychiatric) to ba continued.

The principal adiition in the broad areas of atudy is that of a psycholozical sectioa which consiats of worc not outlined in last yearts protocol but which neverthelese has been going on during the year and has brought forth substantial findings sufficient to point out the neccesity both of its contimuation.and expansion.

Each scientiflc aspect of the projoct has lei to the developaent of proceduros and sothodo which are now of proved usefulress in the study of lysergic and other siailar drug reactions. It is the further application of the notbois which have been doveloped during the past year of experimentation that will be ono of the principal focuses of next year's work.

such as L.A.E. and any other drugs which make their appearance, and to tho study of other drugs in conjunstion vith-L.S.D. with the goal of ascertaining entagonistic·effocts.

to vould also like to expand the base of the exporiment by applying these methods to the study of patisnts with functional paychoses not attributable to drug reactions. This will not only teat the applicability of tha methodo on a broader basis but will dexonstrato nore precisely tha degree to which the findinga of tho studies of the lysergic psychosis can bo applied to understanding schizophrania and other functionel psychoses.

[PAGE 19]
The past yeor's resesrch has dealt to a great oxtent with deteraining the symptors produced by different dosages of L.S.D. and the degreo to which theso syrptons can bo determined by the soçial situation in which tha cubject finds himself and by the basic peroonality and social attributcs of tho subject himself. For tho study of the use of other drugs in conjunction vith L.S.D. to sscertein antagonistic effects it becomes necessary to develop more precise measuremonts of L.S.D. effect than any vhich vo have had heretofore. This constitutês an escentially new fleld of investigation, nacely that or doveloping quantitative measurezents .of

Fron our background of clinical and social obeervations of the lysergic psychosis uhich havo been carried on throughout the past year, more precise and cbjective instrmments or measurenent will bo developod along the fellosing lines: chysiolorical xoacuronents such as polygraph changes and sengitivity to specifio physical-otimuli such as flashing lizht; paychological measurementa of persistence, notivation lack, diatractibility, nenory, reality perception,-richnesa of associations; sociolorical and social peycholozical measurementa such as quality and quantity of verbal production in different struetured social situations.ouch as prcblea solving group diccussion and cccupational tass situations; psychiatric detominations of Esntal otatus (whiçh is escentially a continuation of the present method of clinical eveluation).

Fart I. Picchenical Studios

These studies were carrlod out at this

L.S.P. as a stress agont upon the adrenal cortex.

8

8-13.

[PAGE 20]
Iwelve yolunteers wero chosen. Cn the control day, serely the urinos vere collected at pre-dotermined -intervals, end at 3.00 o'clock in the afternoon, an injection of Aciil, 25 zg., vas given to test the responsivity of tho adrenal cortex,

The urine was oxamined as tovolumo; rate per ninute; and, chemically, as to the content of Creatinine (determined in grams per 24 hours); 17-Ketosteroids (deterained by ailligrem per hour) Sodiun (deterained by. nilligran per hour); Uric Acid (deternined by ailligram Fotassiun (deterzined by milligraa per hour); por ninute); Fhosphates (deternined by nilligram per minute).

On the experimental day,\_the-volunteers-received L.S.D. early-in.
tho norning at & definite hour.The urine again was collected at exactly the
sane tire intervals as on tho control day. Thrce control experisents were carried-out in vhich glucose.was Three control experisents vere carried-out in vhich glucose was

given together with L.S.D.

Froa the data\_of the chemical deterninations cpllected, no definite conclusions can b drawn at the present time. Soms of the resulta were not consistent. There seems to have been soqe technical difficulties, such as errors possibly made by the subjects themselves with regard to the exact time, hour and minute, when they discarded the first morning urine, and also possibly sose errors in chenical determinationa. Hovover, from the overall picturs of the data uhich lend thenaelves-to evaluation, tho impression was gained by that L.S.D. seems to cause the as well es by an inhibitory offect upon tho adrenal cortex. It io-felt that it is of utnost importance to continue theae chonical-deterainationa, Sone slight changes in the techniqua are contemplated in ordor-to establish dats which will allow a groater conoistency, and thereforo, batter correlation.

8-13

[PAGE 21]
Fart Il. Antidote Excerirenta

A number of antidota exporinents wero carried out end more are

contemplated for the futuro.

In the course of these experiments, the impression was gained that the molecular atructure of tho egent üsed had a definite relationahip with regard to the offect of L.S.D. In sone instances, the effect of L.S.D. seemed to have been enhanced, as for inotance the experisents with ergotasine, while definite neutralising effects with other agents vere npt yet cstablished./

Part IIl. Lysergio Acid Ethylanids

A new drug, L.A.s., becane available for us and we propose to investigate it xore thoroughly in the coninp year. This drug was develoçed

at tho .Its nane-ia Lysorgic Acid Ethylaaide. This chiomical ia closely related to L.S.D. the differonce teing meroly,that one ethyl group, C2lg has beea subatitutod by hydrcgen (e) atom. Fron the preliainary report of the e 5

B we learned the followingi :h29 experinents wore carried out on 28 nonval peraons end sone poychotics. -The drug was given in-doses of 0.5 to 0.7 xiliigrans by subcutaneous injectfon. with this amount, normal individuals exçerieneed a schizophrenia-like condition vhich was chsracterized by adynary, indifference, inpaired volition, and phenouena of depersonalization.

In schizophrenics, LAE counteracted paranoid halluciratory excitation. That is to say, the schizophrenica did not loso their paranoid delusions or hallucinations, but becsno indifferent to thea; a phenozenon which sppeared to tho investigator as sinilar to tho effect of prefrontal lobotomy, and therefore, he considered tha offect of LAß as that of a reveraible "chealcol lcbotoay".

8

8-13

[PAGE 22]
On the pasis of théir observations, the inveatigators considered LAE as a new kind of "sedative"; a sedative which in ita offect is noither related to the croup of hypnotica and narcotica of the barbiturie or worphine type, nor to tho group of the sympathico- or parasyapathicolytic chemicalg.

Tho theoretical problem prosents itself to the question es to how it is possiblo that a chemical which, in nonml people brings about a disintegration into a schizophrenic-like conditionj 1s, on the-other hend, capable of tuning doan or noutralizing the excitation of a schisophrenic psychotic.

Other problems present themselves, the most inportant of unich uill be the intercction of LAE and L.S.D. It is possiblo to think that LAE right have an antagonistic, if not to say an antidotic effoct upon L.S,D.

Part Iv. Flysiololcal Studies

(Coabined Fiaysio-psycho-sociological studies)

Tho physiological changes during a lysergic psychosis kay be T sil nangs explored by use of tho polygraph. This apparatus nakes it possible to study many physiological paransters-simultaneously.-In addition a tape recording of the verbal interchange:between the-lysorgized eubject and the examiner is synchronized with the physiological record. Socionstric clessification of intersctions (Bales intoraction-mothod) is carried cut also-by an observer and recorded on the polygraph record.

Thus tho polygraph procoduro can be usod to obtain infomation at the

(a) phyeiological, (b) psychological and (c) soclological level - all funnelod into ono record.

Analysis is being developed elong tho following linesi (1) difference

betveen tho resting physiolorlcal volues pre-L.S.D.-and during lysergic

psychosis. (a) Mifference between atress plysiological values pre and during.

CO

8-13

[PAGE 23]
Tvo classes of stress are uced (a) Essentially physicol (ico application and flickering light) and (b) psychologlcal stress. (psychiatrio interview and specific psychological teet),

Further analyeis related social classification of verbalization during the poychiatrio interview with phyaiological factoro. Thus it is possible to determine whethsr pulse, teaperaturo, respiration, GSR, muscle activity, eto.vary as a function of positively oriented social vorbalization, negatively orientod vorbalization, or rputral. Thlo study is dona both before and durlng lysergie paychosis.

An intereotion chronograph is-now being developed by our electrical
engineer which will do the followingt (1) Record on polygraph peper when
subject is talking ant when exaniner is talking. (2) Accuaulate ths talking
time of each party on an elcctric clock which-can be read at desired
intervale. (3) Give crude estimato of decibel strength of talking of oither
subjeet or examiner. During a lyoorgic psychosis it has been noted clinically
that blocking of speech is one of the earliest signs of lysergic ection.
has already teen showm that verbal-productivity drops during tha lysergio
psychosis. niaht

Further psycto-ptyaiological exploration which wo thins night hold pronise would ba to detersine the nature and dogroe of psychological stress induced by flickering light in rolation to tho disorganising end abnormalising effect of flickoring light upon the E.B.0.. It has been observed that a 15 par. second low intensity flicker will produce a feoling of great tension or irritability in ono subject whereas-it will bo calning and pecilying to another.. This study is elso to to done before end during lyssrgic paychosis.

A number of controlled experiaents were carried out to test the autononio norvous systoa ander the influenco of L.S.D. 'In soso instances, colygrophic, eleetroenccppslographic anl electrocordiogrophie tracinro were taken.

8-13

[PAGE 24]
The muxber of experiments is not yot oufflcient to enablo us to arrive at definite conclusione. Sone of the contemplated experiments, for administrative reasons, have not yot been carried out.

Tha autonomie nervous systet vas tested on subjects vho had received L.s.D. orally, in the amount of one gamà, one-half gamma, snd ore-quarter gazma per kilogran body voight. The greatest-nueber of expsriments wero carried out on subjects who had received cerely one-quarter garna per 1 kilogran body velght.

When L.S.D, in the amount of ono gaea per kilogroa body weight was given, the injection of Epinephrine, as coaparel to the control, shovod a considerable inhibition. When one-quarter gamta per kilogram body weight of L.S. D. vas. given, a nuxbor of the subjects showed a dofinite inhibition of the autonomio nervous system on minimal emcunts of Epinephrine and Necholyl. In these instonces, Epinepärine was given in tho amount of .025 cc. of a solutic: 1:l000, and Necholyl was given in the anount of 2.5 ag. intranuscularly, which ie ono-quarter of the ordinary amount of l0 nilligraãe. As we had anticlpated, working with those ninimal doses of L.S.D., as well ao of, Epinsphrine and Kecholyl, co such inhibition was noted in sone cases.

At a recent conferenze, it was decided that the future oxperiments

should be carried oút with-LSiD. in tho-arount of one-half gamma por

kilogrea body weight.

The experinents seeto bo of significance inaszuch as clinically, putononte disturbancos followipg the administration of L.S.D. are usually observed.

No experimento, for sdainistrativo ręasons, have yet been, carried

out vith vagus atimalation end adrcnolitic and vaguo-blocking agents,

rghas jaat boen given a grant to stody hunan eubjeots at

7

8-13

wme.

[PAGE 25]
by mathods ho has 'adapted to lover vertobrotcs. Briefly, he vill set up
at the (now collaborating with
B two laboratories to study chronically mentally ill patients! responso to award conditioning in terns of their ebility to develop desired behavlor -and to continuo such behavior over long periods of time.

As soon Ro thio huran-laboratory is set up ani relisble curves of behavior doveloped in humana in collacoration withe ve plan to teat effect of lysergic ecid on the behovior curves.

Part V.Clinical Psyehiatrie Studies

(1) be will contime-as in the past year to make a clinical psychiatric evaluation at tho helght of the reaction of all subjects who roccivet.S.D.

(2) Wo vill xake clinical poyehiatric evaluations of tho-effcct ofdrugs in combination with L.S.D. The goal in thia aspect or the project is tha evaluation of entagonistio effects.

Ideally we feel it io desirable to nake several experirents on the sane aubject. For exemples subject uith L.S.D. alonej subject with drug undor consideration alonej subject vith one-half doses of L.S.D. end drugs subjeot with full doseo of L.S.D.-and drügi and probably subject with-full doso of one and half dose of tho other.

This ideal situation is, however, linited by the desire of the subject to have the experinent rapeated on hiaselr and past experience would indioato that very few cudjeots vould sulnit-to moro than two or three tosts during. the course or a yoor. As a result the corbinations of drug and L.S.D. wili be decided in esch instance with reference to tho availability of tho subiect and tho maxinun utilication of eech individual experineat.

9-13

[PAGE 26]
(3) We are particulerly interested in the psychiatrie eileuve
cheaical variants or lyoergic acid of which L.A,ß. is presently available.
Thero is also interest in combinetions of-these cherical variants with other
drugs, the goal, as in (2) being dofined substarcss having antagonistio effccte. (4) We have sone interest in the adainistration of L.S.D. alone or ar rs.D. molecule to patients

slinical psychiatric picture. Inteneity of Symptoasf- Tho clinical psychiatric pictures are graded accoraing to intansity of- syaptons or departure -from normal as mild, noderate or severe. The intensity of individnal symptoms are also graded on s scale of four - zero being within normal lisits aod four being tho nost severe. In cortain instances the departure froa nornal is in a negative or minas diroction as, for exasple, in the case of hanger where pathologlcal absonce of appotite might be rated in teras-of-a-minus sigi end pathologicel inereaso in eppetite in teras of a plus sign. inerease in eppetate u enos end of eindings of

Integration of clinical psychiatric findings-end of eindings.or altered social behavior vill-te further-dovoloped.Only es tho change in the lysorgiaed subject'o ability to function-in varied social situations is related to tho changes in his contal-status can tho basic dynamics of psychoses be escertained. So far the abnonalities doternined by clinical psychlatric evaluation and those founi in hour-to-hour occial observation have to some extent been vieved indopeadently and axtensive -intogrative analysis is required to combine thoss findings.

[PAGE 27]
Fart VI. Paycholozical Studies

The drau-a-person teat (D.A.P.) chould be contimued ao a regular
pert of tho poychological program since it nou appears to be a particularly
fruitful approach in giving leada about the subject's self concept and his
attitudes tovard others in an indirect but meaningful way. It might be
advisable to add to tho more drewing technique a set of routins questiong or
ase the subject to ascociats froely to the figure he has draim. This would give
soue idea of richness of association in rarard to people and in regard to his
own creations. antarmed to inelüdo ten

The T.A.T. Showa vu cards. Intensive analysis of one case has-shown that thore has boen a decrcase in the number of words used when givinz a story under LiSiD, in contrast to tho nuber of words úsed in the nomal states the oubject also opent less time on each picture. The richness of association covld be investigated more thoroughly using this projective dovice by not only counting the words but making an analysis of the skeletoa voria (nouna and verbs) and descriptive phrases (adjectives and adverbs) in the two states and the hypothesis could herebe formulated that unior the lysergized state the subject would be less creatively productiva and give less ricinless in hio \_stories.

It is suggested tnat suncv s are being given and since the Rorschach is apparently being used in full by another group, that wo discontinuo tha partial Rorschach and work with other types of tests. It ia sugcested that in placo of tho Rorschach we use the Vigotsky. The test hes, in the literature, areport of the performanco of schizophrenics. Thia is essontially a test of abstraction end in the adainistration of it tha examiaer can easily insist on or demand verbal reports of the ideation and the hypothssizing that-is going on while trying to do the

[PAGE 28]
This panticular test scems to te one which is a challenge to thoss people of superior intelligonco and is ono which also creates-a-somewhat natural stress situation. Because of the forsrulation and rejection of hypotheses which io involved in the situaticn of this test the subject's ability to concentrate and function in a stress situation can be obcerved. Hio obility to ahift his thirking and his ability to respond to the exeniner who can increase or decreaso the stross sitiation by behavior and coments can also be observed. It seens as though thio test may provide a great wealth of material vhich should sllow for correlation with behavioral observations made in other than the testing oituation.

be an "annoyer" or succossfully koep the subject working when he can no lonser tolerate the frustration cxcerionce in itself. Since this is a cotor task. discbarge of tensioa-through overactivity could bo obsorved. Porcentuel distortiona could also be. asked about efter the tost is corpleted.It would be ipportant to ask at the end of this test if the subject could review his mental proccsseo on this task which is intangible and where it is obvious that there is a solution end en answer.-thother he blares the exaniner-for his difficulty, bleses himself, showe withdraval or\_bostility in response to otress and so oo could be qotimated or evaluatod rore directly.

It is suggestedthat the proverbs bo-discontimued in this neu experiment. Thia is ssentially bocauss of tho epperent inability of tho present younger generation to deal with proverba and their apparent lack of contact vith thea in their everyday living. Since abstraction problens can be dealt with in the Vigotsky both in' a verbal ani non vorbal level, it vould sesn advisable that the remaining tine which is probably all that the -psyehologist vill be given be-devoted to a moro specifically percoptual toot such ae the Bender-Gestalt in which the aubject is roçuired to reproduce

geosetrlo designs.

8-13

0

-21-

[PAGE 29]
Boyond tho drawing of this test it might be posaible also to uso

it for ricbness of asaociation in that the subject would bo esked to tell as. many things as each design nade them think of, or one could see how many yords was suggcstod to the subjeet by the glvon design in one nimts of tine. Thore will be a problea copecially with the Vigotekcy about .civing

the test to tho person in the nomal atate before he has hod L.S.D. sinco once this test hao been solved it is no-longer a challenge to any individual. It io ouggested that for this test the subjects all be given it first whilo under L.8.D. and then have thea teko it a second tine in their nornal stato at which time intensive-imvestigeticn be made of their fəolings, attitudes, reactions, etc.

Fart VII. Sociodynamic Studies

1., Comparative Stucies Using the Interplay Categoried as Basic Tool of Rcsearch

During the past yoar-the inteplay categories have been epplied primarily at a tine when-distortions occar within tho.linit of social situations met or sought out by tho subject. Furthor extension-of the\_application of this method are to inaludo aymptos changos of the subject es related to interporsonal relationships and wider variety of sccial situations.

Soue of the situations in which further study is.indicatodcaret

1. Group vrobleg-solving-oituatione.. .Lysergic subjecta are arked to work on problens. of social and othical nature, and their general conduct is to bo measured by cuch instrunentg as Balcs Interaction Froccoy Analyois and the Interaction Chronogrsph, in addition to the nine interpley catsgorios.

'2. Subjeots put to bed snd given supportive nursing and modical caro.

3. Subjects engaged in ptygical and cports. activity.

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\* Dogcrlbed in cuartecly renorts.Ctaetebardosh

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In conjuhction with thcso studies wo wish to apply tho interpley categories in a comparativo exploration of. therapeutic techniçues with lysergised subjects, and norsal psychotics. Judging by the many extant inconclusive and often contredictory reports on psychotherapeutie techniques, en intensive study of the peychotharaboutic situation, with the aid of the interplay categories, is needed,—Littlo is known, for exauple, of how adequately or how closely therapists' self-expectation about their rolea as therapista are zet in an ectual therapeutic intorvies. Horeover, with thia nethod, the secuential -pattern of therapuutic attitudes and verbal conduct can ba explored.

2. Comcarative Analyeis of L.S.D. and Psychotic Distortions

À further extension of tho aralysis of visual distortions in L.S.D. cubjects is planned to\_includa lnvestigation of distortions which occur in poychotio patienta. Further investigations seem iniicated to determina tha eiailarity, frequency of-occurrence, and the conditions-leading-to and existing at the tine when-distortiono occur -in psychotica and LiS.D. oubjects. Such a study is expocted to-load to a ruch needed undarotanding of the meaning of these distortions to the pationt and their importance-in psychiatrio intororetation and treatment

3. Continuation and Extenaion of Methods of Fersonality Evaluation

Tho relatedneas profilo (see Quartorly Report 2) focuses on the dominant kind of relateineos, the level of perticipaticn and the degree of stress experienco in the six "peoplo erees." The clinical social sumnary scores the qvality of tho individualta general rolatednesa pattern in terms of "spontaneity vs. control" anl so forth (quarterly Roport f2), A report of the use of the profile and clinical srolyois will appear in tho. third . querterly report. Evaluations and analysis during thé past year have boen

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essentially a comparison between the basio personality and the social behavior 1
before ant at the height of tho L.S.D. roaction.

Apart fros extending this type of analysis to vus number of cases, further studies of this nature aro aised at elucidating morecleariy the psycho-social alterationa of the L.S.D. subject's corduot on a chronological hour-by-hour (and perhaps even minute-by-ainute) basis. It is expected that this procedure vould give a more-intensivo dynamic appraisal of the sequence of symptome. The findings froa the application of these mothoas will be integrated both with cach othor and with clinlcal and psychological findinge. caa in LS.D.

h. A Cosperative Study o2\_tho. Fragnatics, Syntactics and Semantica in L.S.D. and Gemino Paychosis In working with L.S.D.-subjects auch difficulty haa been encountered in atteapting to find words which adequately-comunicate the feelings endexperiences of the sobject. This is equally true with ths psychotics. For exaaple, wordo such as "strange", "weird""tangible", "suspended" and so forth communicate very little" to a bagic understanling of the detorioration of thought and emotional proceas which is taking placo in the iniividual. Unless feolings are translated into a vocabulary of motives vhich is meaningful both to the subject, experiencing.the feelings end to the other trying to undorstand the feelinga, the barrier to. comunlcation continaes to exist and little aid can : be given. The tashsst beforo ua hero is to viiorstand ways in which thsse feelings can bo more edoquately end easily described and interpreted.To this end ve propose to maka an intensive linguistic analysis of the recorded thorapeutio intervlew matorial. The-approach is planned to be three-foldi -1よ-nã

attituies, ari of the exprossive behavior involved in

cospunication.

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Analysis of tho granmatical structure or oyuw-2. that ia, a study of the rolationship of wordo and sontences to each other. This will include a study of the degree of loosoness, precision and fragmentation, and the selectivity and flexibility of associations (according to establiched laws of association.)

3. Analysis of semantics, that ia, a-study of coatent meaning. This type of content araiysis-dealo-with tho\_meaning of thingé and events and people, external to the subject, that is, what aeers most significent to the cubject about these thingo, vhether they be-prosaic, conventicnal-or imaginative, symbolic.and interpretive.

In this tyce of analysis, ve expect to be guided by the oxtant 1L

literature on this subject, in particuler, a recent-articla on "Language Behavior in Hanics" by K. Lorenz in tho-Archivea of Nourology and Psychiatry, January, 1953. aninFroran

5. A Study of L.S.D. as a Usefal Adiunot in the Hospital Trainint Frogram Studies of.the past year resulted in tha accumulation of oufficient infonaation to contimue investigation in thig arca. Considerablo data has been gathered on the effects of the L.S.D. experience of the personnel froz the point of view of its capacity to-inerease-their-ability to understand end eid patients. Detailed snalysis of this inforpation has yot to bo made on the asount and kind of understanding and knogledge gainod and how it is applied by personnel in patient care.

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Two group experioncoa ero plaaned for further studyi

1. Group scssions uill be beld with personnel who have had the experience to dotorino the oxtont of the knowledgo they have gained in\_the\_nanagecent\_or psychotio patients.

2. There will be group meetings in which personnel who have had L.S.D. and pereonnel who heve not taken the drug will participate, the-lattar serving as controls.  This io expectod to prove useful in a general tzining prograa for porconnol in paticnt management.

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1. Salaries

C.. Experitental Subjects

2. Expendable Supplies

3. Femanont Equipment

h. Travel

TOTAL\$39,500.

Tho responoible rosearchers vill continuo es of

ESTINATED BUTGET

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August 19, 1954

C Dear Gpan

C This is to inforn you that ay formerwk nurber has been changed

No collect colls vill be accepted at this number.

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ej

Dote of Origirel Feriod Tce Allctamat Anause of Authoriration CoRN4 tecdd to Clcation 10 June 1953 11 Sept 54 3.2502.1000140290.00

Halnce 3/19/5.3 13430.00 26860.00 2 3/5/5+ 26860.00

rjet alrud S Mures 10

SSCRST