[PAGE 1]
Since writing to you last December óth we have completed a number of experiments which are descrlbed below.

Bufotenine. No further, work has been carried out with this substance due to the ngth of effects of doszs ranging up to 2 mg. orally. Letter recelved from Dr. Evarts of the National Institute of Mental Health ladicates that no significant effects other than o translent drop in blood pressure cccurred after as much as I mg-zintravenously to normal volunteers. The Instltute appears to be furniag its attenticn tc other susstances found in the cohoba beans aad i witl awalt with interest any infornatlon from this source. The lnsfitutes have kindly agreed to supply me with cohoba'snuff so that we can ascertaln whether there is anything in fhis been thát induces sufficient mental chanoe to be of Interest.

Chlorpromaziae as an Antidote to LSD-25. We have now completed seven experiments. The first two of these were reported on September 15. l954. .The remaining experliments are descrlbed In order and are numbered 3 to 7. In general the effects of chlorpromazine haye not been as good as would have been anticipated from the two original experiments. Although, in general, there is a trend indicating reduction of the LSD-zffects the only consistently slgnlficant change has been in pupiliary size.

Exoerlment 3. In thls experiment the antidotal effects of lO0 mg. chlorpromazine nlven 30 minutes before 60 mcg. of LSD were studled in 7 patients. Includlng ó whites and I negro. The purpose of the experinent was to study the dose rangz ovzr which antidotal effects could be zxpected. The dose of chlorpromazlne was elevated 25mg. above that given In Experiment 2, and the dose of LSD was elevated 20 mcg. Obseryations included knee jerks pupillary size, systolic blood pressure, and questionnaire. All these measures were obtalned hourty for two hours prlor to administratlon and for elçht hours after administration of LSD.

A-17

IN REPLTING. ACDRESSTHE ADOICTTON RESEARCH CENTER MATIORALINTITUTES OF MENTAL HEALTH U. S. PUSLIC HIALTH SERVICE HOSsITAL Bqz 2000

28 January 1955

Declassifiedby187475 date4 FEB 1977

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date Declassified by187475. 4 FEB 1977

[PAGE 3]
Sincerely yours lee Harris istell, M.O. Director of Reszarch

Declassified by187475 date 4-FEE 1977

A-173

Hi:rn

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EFFECTS CF 1OO NG. CHLORPROWAZINE

GIVEN 30 MINUTES BEFORE 6C NCG. LSD-25

1 Figures are means on 7 patlents, 6 white and I negro.

EXPERIMENT 3

二

Declassiñied by—187475 date\~ 4 FER 1977

[PAGE 5]
75 NG.CFCHLORPROMAZINE

GIVEN 3O MINUTES BEFCRE 6O MCG OF LSD-25

Figures are means of 7 patients, ó whlte and 1 negro.
Figures for knee jerks, pupillary size, and blood pressure represent area under time-action curves (8 hoursl.
Questions show number of positive answers in 8 hours.
Clinical grades on l-4 basis.

Declassified by 187475. date 4 FEB 1977 A+71

EXPERIMENT 4

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75 MGM.CFCHLORPROMAZINE

GIVEN 30 MINUTES BEFORE 6O MCG. OF LSD

Figures are means of obseryations on l2 negro patients. Figures in knee jerk, pupillary size and blood pressure . resent areas under curve. Questions,humber of positive answers in 8-hour period afdrug. Clinical Grades on l-4 basis..

EXPER IMENT 5

Declassified by -187475 date  4 FEB 1977 A-170

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Figures are means of observations on 12 negro patiznts over 6-l/2 hour period after CPM given.
Figures represent area under time-action curve lknee jerk, blood pressure, pupillary sizel.
Ouestions show aumber of positive answers during ó hours.
Ciinicai grade on basis of i-4.

EXPERIMENT 6

Declassified by 187475 dateFEB 1977

[PAGE 8]
ÉFFECTS OF 25 MG. OF CHLORPROMAZINE 1.M-

GIVEN 1-1/2 HRS. AFTER VARIABLE DOSE OF LSD-25.

Figures are averages of observatlons on l2 negro patients over ó-l/2 hour perlod after administratlon of CPM.
Dose of LSD varled between 60 and 150 mcg.

Declassified by187475 date 4 FEB 1977