[PAGE 2]
Receipt is hereby acknowledged of Treasurer's Check No. L101412, dated October 30th, 1964, drawn on the

DATR 4 No1. 1964

RECEIPT

148-2

[PAGE 3]
For consultation and special services rendered, May and June 1964

I certify that services or aterials have\_been satisfactorily received anl Mhaaxreaditures were incurred on offi

[PAGE 5]
O

Receipt is hereby acknowledged of Treasurer's Check wo. 208818. dated August. 12.196h.dravo on the

NAME:

DATE:18AU9. 196y

11 July 1964

For services rendercd, June 1964.

\$500.00

À cortiry that servides or aterials bavo boen Fatisfactorily received n4 th expenditureo vore incurred on offasbrseeoen

[PAGE 6]
Gentlemen:

Current-work-in this laboratory by Dr and associates. Tho effects of a synthetic dimethyl heptyl analogue che active ingredient of marihuana are being compared with those of thiopental on EEG arousal in acute cat preparaticns, EEG and behavioral arousal"in chronic cat preparations, and on the transfer of sensory impulses through thebrain.stem reticular formation. This work is aimed at elucidating thc mechanism of the CNS depression caused by the marihuana analogue.

CONGULTANT PHARMACOLOGY AND TOXICOLOVY

148-3

[PAGE 7]
(A R P)  y

(ur parrts ueym)

[PAGE 8]
RECEIPTS

Receipt is hereby acknowledged of Treasurer's Checks Nos. J101291 and L101292,\_dated 10 June 1964, drawn on. thc of the payable to in the amount of \$500 each.

NAME

DATE2.5 1964

[PAGE 10]
For services rendored, May 1964

I certify that services o torials have been satisfactorily received ni tho expendituros were incurred on officil .

11 May 1964

\$500.00

#7

[PAGE 13]
PROJECT CRYPTO : MKULTRA 148

INVESTIGATOR : Dy

RENEWAL DATE : October 1964

1. This project provides for the utilization of the professional services of Dr. Since the initiation of this project he has proved to be a reliable source of information on the pharmacological and physiological information of spocial-chemicalcompounds of current interest in the program, The information provided has been utirrzedin Maintaining and advancing our knowledgeability of unpublished data and information which permits usa better basic understanding of the sites of action of materials significant in intluencing animal and human behavior and guides us in selection of material and experimental techniques.

2. He has reported on detailed experiments he was using to demonstrate that high and low spinal sections blccked the action of a dimethyl heptyl substituted tetrahydrocannabinol on the polysynaptic flexion reflex whereas the mid brain section did not. The site of action is indicated in the lower brain stem.

3. The consistant deprcssant action on these refloxes is probably due to a summation of possible depressant actions locally on the reflex system and at points in the motor facilitory systems. Itis. hoped that work in this area will eventually identify the mcchanism responsible for the ataxia produced by high doscs of the active principle of marihuana.

4. The long latent pcriod experienced in the use of C-9 may be attributed to the mineral or vegetable oil vehicle which is used frcquontly in oral dosage forms.

5. Attention has been callcd to the diethylamide of 2-methoxy-4-allyl phenoxy acetic acid which posscsses a narcotic and powerful analeptic respiratory action. It

1486

31 March 1964

[PAGE 14]
148-6

causes stronger respiratory stimulation than that obtained with most analeptics. .C, B

6. A report by of thei was given to Dr tor review and criersm, This re port is of corsiderabte-interest (to ince it describes interactions between pesticidal chemicals and psychotherapeutic compounds.. The.pesticidal. chemicals are of the acetylcholinesterase inhibitor class, a class which includes our Cw organs phosphate materials. Pentobarbital and 1-Naphtbyl N-methyl carbamate ("Sevin") (a reversible anticholinesterase material) gave directly additive responses. Chlorpromazine greatly augmented the response to "Sevin". This was not related to changes in the brain cholinesterase activity. Pilocarpine which does not block cholinesterasc increased and prolonged the anticholinesterase action of Sevin. This pattern offers interesting possibilititeor ipteraction among materials of more direct interest to

7. Dr.ris summarizing the latest information and thc state of The art in-setting the stage for and triggering epileptiform seizures in mammals. .He will maintain his contacts in the various domestic and overseas laboratories with a special attontion within security on those phenomena of interest to

8.Drvill continue to provide profossional services, review and set up protocols for critical preclinical animal testing, will\_seek\_out\_sources of informatiop aod provide data available on direct request of r-whenever data\_or\_information\_isirevealed.to him wireh ne believes will be of interest to

O

[PAGE 15]
1487

Ce Receipt is hereby acknowledged of Treasurer's Check No205936,. dated April 9, 1964drawn on the Janeor \$250.00.

NAME

DATR 18MpY 1964

[PAGE 17]
For services rendered, Merch 1964

A I certify that gervices or mater satisfactorily received xoen: Aaros were incupred on offici

13 February 1964

For services rendered, February 1964

I certify that services or ratorials have been satisfactorily roceived an? tro expendituros wore incurred on officialbistnoss.

[PAGE 18]
Receipt is hereby acknowledged-of·Treasurer's Check No, L101139 dated March 11, 1964, drewn

RECEIPT

[PAGE 20]
For services rendered, January 1964

11 Janvary 1964

I certify that servidocisearaao mave tee satisfactorily xeceived and the expenditurea were inourred on offtale-busluiss.

ADated

[PAGE 21]
Check No. 0128236, datcd February 3. 1964, drawn payable to Dr, 1nt 01\$1,250.00.

Date13 725.64

[PAGE 23]
11 Jenuary 1964

For services rendered, Jenuary 1964

\$1250.00

I certify that services ot aleraao tve vevn satisfactorily received n? the expənditures were incurred on offictalhusiness. Y

[PAGE 24]
Receipt is hereby acknowledged of Treasurer's Check No. Y 400369 dated Decomber 31 1963 drswn onthr

Dato8 gamanny 1964

[PAGE 25]
148-10

Consultant Pharmacology and Toxicology

For services rendered, December 1963

14 Dccember 1963

\$750.00

Reed clacte. 8fan 1964 C

I certify that services  ttao ve v satisfactorily received o? tho oxponditurod wero incurredon officiakbas!nesa

[PAGE 27]
for sorviccs rendered, Decenber 1963

satle ndieereo

Consultznt Pharmecology end Tostcology

14 December 1963

\$750.00

148-10

[PAGE 28]
O

Receipt is hereby acknowledged of Treasurer's Check No. 0121056, dated 6 December 1963  drawo on the

,C payable to pr. in-the amountof \$500.00

Date 13 alee. 1963

[PAGE 29]
For services rendered, November 1963

Payment rcered, 13 Dee. 1463

[PAGE 30]
(HI PRdN)

[PAGE 31]
MEDQRARDUM FOV SUBJECT

: MRULTRA, Sabproject Ko. 148

Under the authority granted in tha meaovardua dated 13 April 1953. from the bCI to the Da/A, and the exteesion of this authority in subocovent ueuoráuda, Subproject l48 has boen ayyyoved, and \$5,000.00 of the sver-all Project MXUbTRA funda have been obligated to covox the subprojeety expenses and saould be charged to coat center 412o-1390-3902

1 CERTIFY THA FURNDS ARE AVAILABLE
OBGANON ENE9 3902-
CHARGE TO ALLO

CUOUS

batet 24 October 1963

[PAGE 32]
SUBJECT : MKULTRA, Subproject 148

1. The purpose of this subproject is to proyide a mechanism 1 to utilize the professional services of Dr.4

2. The services fall into the following catcgories, special consultatiors, lectures, briefings, participation: in planning sessions, participation in and reporting on special meetings and conferences and provision of special information reflecting progress of research and development programs in laboratories. known C to be conducting work of interest to

3. Dr ill, utilizing his position as-chairman of the Departmènt of Pharmacology consultantships with drug companies and his direct\_entre into many U.S: aud-foreign academic laboratories, obtain and provide the very-latest information and findings in the.field of pharmacology which may be of interest and value to the orogram.

4. As a recognizedauthority in the fieids of toxicology and pharmacology, Dr. is personally acquainted with leaders in the institutional and semi-industrial research and development

AMKULTRA

DRAFT

24 October 1963

MEMORANDUM FOR : THE RECORD

[PAGE 33]
laboratories and professional societies.and can provide invalu-.: ablc assistance and information.unavailable.thru normal.channels.

5. The estimated cost of this program for ono year is-\$5,000.00.:Charges should be made against Allotment Number 4125-1390-3902. C

6. Payments to Dr. will be on a ręimbursable basis for professional serviccs rendered.

7. Dr.  posses an Agency TOP SECRET approyal.

Distribution: Original only

2

[PAGE 34]
Date 24 October 1963

G BEHAVIORAL ACTIVITIES SUPPORT Branch Category- Advanced Research (VIc)

· Project Title N. A. Item ClassificationN.A

Project Crypto. MKULTRA: Crypto Classifiçation Unċlassificd

Branch Project No. N, A.Project Engineer λ.

MXULTRA 148 Task No. N.A.

Type of Contract MKULTRA Date Initiated -1-November 1963

Cost\$5,000:00 FY 64 Complction Date October 31,1964

Purpose: To provide mechanisms -for-professional- services; physiological, pharmacological aud toxicological information on new materials and drugs currently. in the research and development stage. in certaininstitutional and pharmaceutical laboratories.This activity will support TSD/BB activities concerned with influencing animal and human behavior.

Status: Being initiated.

Requirement: Internally generated in TSD.Repeated requests from for support several DD/P elements includin requires be in the position to maintain immcdiate re sponse capability.

[PAGE 39]
1125\~1390-3902 Cost Account.

14813

[PAGE 40]
MEMORANDUN FOR : C/TSO/FASS

SOBJECT : NKULTRA, Subproject No. 148.

Under the euthority gxanted in the menozandun dated 13 April l9bs, from the DCI to tho DD/A, and the extension of this authority in subsequent momoranda, Subprojeet 148 haa beon approved, and \$5,000.00 of the over-all Projeet MULTRA funde have been obligated to cover the subprojeet's expenses end should be charged to cout centor\_4125-1s90-3902

A

PROGRAIDANEGSE

Concur!

hsot. Cater, TSO Yor DE

Conour:

APPROVED FOR OBLIGATTON OF FUSFS:

rate:

CIRTEY THAT CUNES ARE AVARLABLE 299

1483

Date:24.0ctober 1963.

[PAGE 41]
(uI Poriid uay)