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6 September 1945

MEMORANDUI

Research and Development Branch

Special Assistants Division, R&D

SUpJECT: Final -Summary Reports

1. Herewith attached are the following finul sumary reports submitted from Special Assistants Division, Research and Development Branch:

a) "K" Tablets b) T.D.

Special Assistants Div. Research and Development Branch

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SPECIAL ASSISTANTS DIVISIÓI, R&D

FINAL SUMEARY REPORT OF K TABLET

5 September 1945

INTRODUCTION

Authorization: There is no letter of authorization in the Special Assistants Division files but it is understood from F former Srecial Assistants Division that such authoriaticn was given orally by , former Research and Development Branch. Special àssistants Division was to cooperate with the Medical Franch in giving advice and doing such experimental work as was possible within the Special Assistants Division.

Experimental work was done at and in the laboratories of Special Assistants Division.

Purpose: A small quickly soluble pellet was desired which would cause rapid unconsciousness ("Knock-out") of a victime but there should be no possibility of death being caused.

MATERIALS AND LXI'ERIMENTAL NETHOLS

The choice of suitable-"knock-out" material was rather limited because almost all drugs, if given in sufficient dosages, are fatal. The difference between the "knock-out" dose and the lethal dose.depends a great deal upon the individual subject so that a knock out dose for one person might be a lethal dose for another. Therefore, materials had to be picked which had a relatively large differences between "knock-out"-dosages and lethal dosages. Chloral hydrate was one suitable material frcm this point of view.

However, from the point of view of making suitable pellets, chloral hydrate was not satisfactory because at ordinary temperatures it. is a liquid. Therefore, a suitable water soluble binder had to be sought.."The binder chosen was Carbowax LO0O, produced by Carbide and Carton\_Chemical Company, New York, New York.

Here again another difficulty arcse--the pellet needed to produce the two requirements above became a wafer.

Neveriheless, a suitable wafer contained the following proportions:

Chloral hydrate 2.5 grams Carbowex h000 7.5 grams

The second nost suitable material from the dosege point of view hut the first choice as far as binder and size were concerned was a mixture of-morphine

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and hyoscine with a glucose binder. These materials were to be in the proportion of:

Korpmne tartrate

Hyoscine hydrobromide

0.75 grains
0.20 grains

and sufficient glucose syrup to bind the materials.

Experimental Methods: All physiological data was obtained fron standard pharmacological books with the coments of the Medical Branch.

In the case of the chloral hydrate wafer, the Carbowax LOO0 is first melted and the chioral hydrate dissolved therein. After hardening, the mixture may be formed into a wafer in a suitable pellet press.

In the case of the morphine and hyocine, a dry mixture is prepared, moistaned with the least possible amount of glucose syrup and formed into a pill by means of a suitable pellet press.

RLSULTS

The chloral bydrate wafer will dissolve in two to three minutes in water or a water-alcohol mixture. Because of its bitter taste, it is suggested that a flavored beverage be used such as tea, coffee, whiskey or other alcoholic drinks. The amqunt of chloral hydrate used is well below the ten gram lethal amount even for the most sensitive victim. The effect would take place in ten to fifteen minutes, reach its effect in one hour, and woar, off in five to ten hours. During this time a man could be roused but not easily.

The morphine-hyoscine mixture will also be dispersed in the same liquids in about the same time and should be used in the same manner. The effect will start in about thirty minutes and last several hours. The pellet does not produce loss of sensation but reduces sensatioh and greatly diminishes the power of attention and the power of memory.

The difference between the "knook-out" dose and lethal dose in this
latter case is not as grsat as that of chloral hydrate. In the case of chloral
hydrate the factor of safety is about foer to one, whereas in the morphine
hyoscine mixturs this factor is about two to:one. é

CONCLUSIONS

Although no "K" tablets reached the field, the correct proportions and procedures have been investigated, so that at some futirs date, suitable pellets could be produced.

RECONSENDATIONS

Some law enforcement agencies might have a ise for "K" tablets.

Srecial Assistants Division Research and Developnent Branch

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SPLCIAL ASSISTANTS DIVISION, R&T

FINAL SUM ARY REPORT OF T. D.

6 September 1945

INTRODUCTION

Authorizationa, This project was initiated by a memorandum fron Research and Devclopment Branch to

Ledical Branch, dated 19 January 1945, entitled T. D. It was understood that Special Assistants Division would offer any advice or laboratory facilities desired.

Puipose: The material to be used was to produce unihibited truthfulness in an interrogated person.

MATERIALS AID EXPLRIKENTAL METHODS

Materials: The active material selected for the physislogical and psycological test was marihuna acetate in a purified form. This substance was made into a 50% by weight alcohol solution.

Experinental ethods: When the solution was prepared varying amounts were incorporated into tabacco for making cigarelts and.also were dissolved in drinking water. The amounts involved varied from 1/100 cc to 1/L00 cc of the alcohol solution. The T.D. was administered without the victis being aware of the proctedure by getting hiz to smoke a cigarette or drink a glass of water.

RESULTS

Reactions of the' victins to the interrogation procedure are given in the attached copy of a letter to The Director, Room l2ù, Adinistration Building from dated 31 August l945, on the subject of T.D.

CONCLUSIONS

Indications are that uninhibited truthsulness can not be obtained by - this method.

RECOMIENDATIONS

None

Special Assistants Divisiun Research and Development Sranch