[PAGE 1]
109-1

[PAGE 2]
SECRET

[PAGE 3]
SCHEDULE FOR --GFUND DISBURSEMENT

\$5,270.00
5,270.00
5,270.00
5,270,00

SEORET

[PAGE 4]
Project: MKULTRA, Subproject 109

Dato Initlatod: July 1960

Date Expires: Novembor 1961

Pumds-currort yeari \$21, 923, 20

Purpose: To develop bioastay and pharmnacodynamic techniques in the field of enzymology requlred in the RB chemical ageat program.

Statar: Preliminary survey work is not yet comploted since the program is cnly in i's elghth moath.

[PAGE 5]
OORUT

[PAGE 6]
CRRTTVICATION

Thie is to cortify that I heve received an accounting for HULTRA sub-project 109, Invoics 3, vhich rofleots epenses in the amount of \$21,08o.00. This eccoumnting is being retained 1n tho project file and is availehle for roviey by tho specially dosignatod certifying afficer.

I turther certify that to the beat of my knowledge and belief, the expensea listed in the acoounting were for the purpogcs authorised in tho approved activity.

109-3

SDDNEY COTLIB DC/TSD

GAOur 1 Exclyded from netomalic downgradiag and dectassification

[PAGE 7]
In accordance with the terms of your grant to Dr.
in duplicate ts the final expenditure report.

[PAGE 8]
Prinoipal Investigator:

Profeesor and Head of the Depsrtaant-Pharuaceuticel and Vedicinal Chenistry-College of Pharmacy

243620\~4609R The B

109-4

[PAGE 9]
CK#3671-7-63 10,540

10.540 CK3702-7-63 21,080

NOT DUE UNTIL085 SEEMEMO FM DTD8-26-63 C

[PAGE 10]
With reference to your letter of October 8, 1964, please find enclosed a copy of our report of August 31,1963, and copies of correspondence from Doctor relating to reporting requirements

INVOICE #3 WILL NOT BE DUE UNTIL AUG19605

[PAGE 11]
In accordance\_with Doctor X.
telephone: Thureday afterncoh, 31 January 1963), I should instructions (per like to requeat that you subait to thee

I. Only one additional Terainal Report, dated l September 19é) in connection with the grant award announced in Doctor lotter of 6 Hovember 1961.

I1. Only one Terrinal Roport, dated 1 Auguet 1964, in connection with the grant award announced in Doctor letter of 10 December 1962.

It is my underatansing that no other fiscal reports need to be submitted.

[PAGE 12]
INTEROFFICE COMMUNICATION

Datc Auguot 26, 1963

Ao 2 result conversation with Dr of the Monday
afternoon, 26August 1963, the contents of my memoypf 26
February l963:should be revised as follows Please submit to the 3

I. Only one additional Terminal Report, dated l September T6), in connection with the grant award. announçed in-DoctorS letter.of 6kovember1961.

II. Only one Terminal Report, dated 1 August: 1965, in connection with the gränt award announced in letter of 10 December 1962./NVc/CE #3

It is my underatanding that no other fiscal reports need to be submitted.

C cc Dean Dr. A

[PAGE 13]
In eccordance with the teras of your great vith Dri enclcsad in duplicate is the fiñal expendicure report for the grant puriod Deccaber l, 1961, to Aguat 31, 1963.

Yourt very trulj,

[PAGE 14]
December 1, 1961 to Auguet 31, 1963

Principal Imvestigator: toPh.D., Professor and Head of the Department of Pharmaceutical and Modicinal Chenistry, College of Pharmacy.

Dete: August 31, 1963

Outetanding Unemcumbered Itea AppropriationPaymentsEncumbrancesBalances

I certify that services or tarinls have been satisfactorily receitp?pe oxvenditures were incurred cn offieltsinyss

[PAGE 15]
Budget Report on Research Project

December 1,-196l-to May-31,-1962

Project Title: The Synthesis and BiochemicalEyaluation of Potential Psychopharmacological Agents.

Principal Investigator: h.D., Professor and Head of the Department-of Pharmacentical and-Medical Chemistry, Collegc of Phatmacy.\_

109-8

2.

[PAGE 16]
Project Title: The Synthesis.and Biochemical Evaluation of Potential Psychopharmacological Agents.

Principal Investigator: u Ph.D., Professor and Head of the Department of Pharmaceutical and-Medicinal Chemistry, College of Pharmacy.

Date: August 31, 1963

Outstanding—Unemcumbered Appropriation PaymentsEncumbrances Balances

2,749,562,749.56 15% of Entire Budget; to cover Indirect Costs

109-8

[PAGE 17]
$$
D A \bot E
$$

$$
\because A P P \bot A C V E D
$$

$$
2 - 1 9 - 6 0
$$

$$
2 1 , 0 8 0 , 5 0 .
$$

$$
8 - 1 = 4 0
$$

$$
2 1 , 0 8 0 , 0 0 \cdots
$$

$$
1 1 - 2 = 6 1
$$

$$
2 4 , 0 8 5 , 8 0
$$

$$
1 1 = 1 3 = 4 1 . 3
$$

$$
2 4 , 0 8 0 , 5 0
$$

$$
1 1 = 1 5 \cdot ( n 2 )
$$

$$
2 1 , 0 8 0 , 0 0
$$

$$
i a - 1 0 = ( 0 . 2 )
$$

$$
2 1 , 0 8 0 0 0
$$

$$
\frac { \frac { 1 } { 4 } + \frac { 1 } { 5 } } { 4 - 1 - 4 } < 0 -
$$

$$
p A Y M E + l T S ^ { - }
$$

$$
3 , 2 3 2 , 1 7
$$

$$
7 - 1 - 6 0
$$

$$
2 l _ { 2 } ^ { - } \Delta \theta _ { 2 } \Delta \theta _ { 2 } \Delta \theta _ { 2 }
$$

$$
2 1 , 0 8 0 , 0 0 0
$$

$$
5 = 3 1 - 6 1 1
$$

$$
( 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 0 1 1 1 0 1 1 1 1 0 1 1 0 1 1 0 1 1 1 0 1 0 1 1 0 1 1 0 1 0 1 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 0 1 0 0 1 0 0 1 0 0 1 0 0 1 0 0 1 0 0 0 1 0 0 0 1 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
$$

6,284.00

$$
8 . 3 1 - 0 . 1 1
$$

$$
2 1 , 0 8 0 , 0 0 0
$$

104-9

[PAGE 18]
Date 19 Pabruary 1964

BEHAVIORAL ACTIVITIES SUPPORT BB Behavioral Control Materials (V1a) Branch D1a44 Category

Synthesis and evaluation of poteatial paychophar- Uoclasaified Project Title macological compounds Item Classification

Project CryptoKKULTRACrypto Classificatlionpclassified

Branch Project No N.A Project Engineer. B C Contractor.

Contract No..MKULTRA # 109 Task No.

Date Initiated1July-1980 Type of Contract.

CostFY-63\$21,923.20Completion Date30 Juno 1964

Purpose: Elucidation of interrelatiorahipa between molecular constitution and biological response of cbemical coapounds of interost to TSD.

Status: Teruinal year of a basic biocheaical: research, All büt the fipal phases of tne research bas been completed and the reports subaitted. Reports relating to. final phasos of the contract vill te received upon completion.

Requirement: Internally generated in TSD by need for special biologically activo conpounds and basic information of their characterization,

109-9

REVI8ED

[PAGE 19]
Date. 5 September 1963

of potential psychophar- Unclassified Project Title\_macological compounds Item Classifcation

Unclassified MKULTRA Crypto Classification Project Crypto

Branch Project No.. N.A. Project Engineer

r⁻ MKULTRA # 109 Task No. N.A. Contract No.

1 July 1960 Type of Contract N.A. Date Initiated.

30 November 1963 Cost \$21,923.20 Completion Date

Purpose: Elucidationof interrelationships between-molecular constitution and biological response of chemical compoundsof intèrest to TSD.

Status: Terminal year of a-basic biochemical research.

Requirement: Internally generated in TSD by nced for special biologically active compounds and basic information of their characterization.

109-10

REVISED

[PAGE 20]
109-11:

June 12, 1962

DearA

This is just a brief note to let you know that 1 have received the check for \$3,000.00 (three thousand dollars) from the

Please accept my sincerest thanks,

By Air\_Mail

3/63

[PAGE 21]
Budget Report on Research Project by the at the December 1, 1961 to May 31, 1962

Project Title: The Synthesis and Biochemical Evaluation of Potential Psychopharmacological Agents.

Ph.D., Professor and Head of the Department of Principal Investigatort Pharnacentical and Medical Chemistry, College of Pharmacy.

3//62

109-12

[PAGE 22]
Receipt is hereby acknovledged for the following two checks:

Treasureris Check No.dated 27 December 1962 1n theagount or \$843.20, payable to B drawn on ε

Treasurer!s Check No. dated 27December 1962 B in the amount of \$21 Co.00, payable to drawm on

RECEIPT

[PAGE 23]
Ax T V S       t t ar         r

[PAGE 24]
Object Class

(When Füled In)

169-13

[PAGE 25]
109 \$21,080.00

Doesnot imclude 843.20

15 Movember 1962

109

BB.

Authorizatioa  3

[PAGE 26]
x Td  o  L    t   y Pa Ar A    A de Atis 2  xr

62. o

[PAGE 27]
109 \$21,080.00184/3.20

3125-1390-3902

4 Der 1962

L CRIY PAT

15 November. 1962

Authorization #3

[PAGE 28]
MEMORANDUM FOR : THE RECORD

SUBJECT :  MKULTRA, Subproject 109

1. The purpose of this subproject is to provide funds for the continuation of a study of potential psychopharmecological agents. In particular, studies will be directed to. the elucidation of interrelationships between molecular-constitution and biological reepcnse. Studies will be conducted into the biochemical characteristics of certain types of Chemical moieties which are of interest\_to TSD/BB in carrying out its program on-the development of meansto control Hunia Behavior.

2. The\_attached Budget indicates the extent of the investigations that will be carried out under the direction of Dr. in facilities available at the The fundo-for this project will be transferred üsing the as a cutout.
3. The studies being carried out under this subprojeet were originally planned to cover a period-of approximately five years based upon the attached proposal, However, the change in emphasis

109-3.

109-15

DRAFT

15 November 1962

[PAGE 29]
of the present TSD program requires that these plans be altered considerably. The investigation has therefore agreed to produce as many actual end-item compounds as possible during the next year and also-to consider this às the final-year of the project. For-this reason the attached budget bas been-scaled dowm from the original estimate of \$29,578.00 to\_\$21,080.00. The lower figure reflects mostly lowered persopnel costs occasioned by the simpler developmental activities now planned

4. The cost of this progrem for a period of one\_ year will not exceed \$21,080.00 to which wust be added the four per cent fee to themaking the total amount \$21,923.20. Charges\_should-be made against Allotment No. 3125-139)-3902.

5.The Wrequires that the

submit to them a summary accounting on an annual-basis of all monies"received from the Also, unexpended funds w1ll be returned by the as soon as possible upon the close of the-grant year.

6.A requirement for a six months' infornal accounting on the part\_of the principal investigator is waived.

7.It is not anticipated that any permanent\_equipment will

be needed for this program.

一

109-15

2

[PAGE 30]
8. : In connection with travel-under this project, it is agreed that the Agency will accept the travel documentation and accounting which conform with the practices of the

9. It is agreed that technical reports reflecting the / progress-of the research program-shall be submitted at-mutually acceptable-intervals.

10.All personnel connected with the planning and monitoring of this program possess TOP SECRET Agency security approval,

11. This project will be unclassified after it leaves the

Chief BIOLOGICAL BRANCH

Attechment: Proposal-& Budget

109-15

Dietribution! Original only

109-3

[PAGE 31]
Project Title: The\_Synthesis and Biochemical Evaluation of Potential Psychopharmacological-Agents.

Principal Investigator: Ph.D., Professor add-Head of the Department of Pharnaceutical and Medicinal Chemistry, College of Pharmacy.\*

For the past several years, the\_applfcant has been engaged in research-involving (I) the synthesis of-organic entities having potential effects-upon the central nervous system, and (Il) the evaluation of conneccions between the chemical and pharmacodynamic properties of these compounds. The applicant is primarily interested in the fundamental study of relationships between molecular constitution and biochemical response, and is particularly concerned with the effect of gradual changes in the chemical structure of synthetic entities upon isolated enzyme systems.The reader is referred to (A)\_reports submitted earlier to the 1-7, and (B) published accounts 8-19 for supplemental information.

The applicant plans\_to continue his tnvestigation in accordance-with the principles set forth in the cited coomunications. Specifically, he intends-to:

1. Synthesize several series of new compounds patterned after (a) organic amines known to affect-the\_central nervous system, and (b) moieties acknowledged as substrates in enzyme systems implicated in the pharmacodynamicsof compounds possessing psychopharmacological properties. The member compounds of each series will be designed with gradual changes in their constitution, or physical properties, or both; furthermore,-they wtll be planned in such a manner that potential differences in the'interaction between the member coupounds of a given synthetic Series and a given enzyue may be-interpreted in terms of concepts reasonably well established in contemporary theoretical chemistry.

2. Study the effect of-these entities upon-(a)-isolated enzyme preparations believed to be associated with brain function, and (b) othér plausible biochemical systems.

3. Explore relationships between-the biochemical activity of each series of derivatives, and the successive changes in the chemical and physical characteristics of the member compounds.

At present, our synthetic work-is centered around series-of arylalkylamincalkylacetamides, and pyridine- and piperidinecarboxamides which could be visualized as moieties derived from the psychotoaimetic-molecule LSD (see Figures I, II,III and IV; other series have been planned).

Concurrently, the completed compounds are being evaluated in isolated cholinesterase systems in which LSD has shown remarkable specificity. Our manometric-procedures

\* Effective July 1,-1960 (on-leäve of absence July 1, 1960 through June-30,:1961):

109-16

[PAGE 32]
109-16

Pago:Tmo

[PAGE 33]
109-2

109-16

Page Three

[PAGE 34]
Page Four.

[PAGE 35]
Page Five

109.2

[PAGE 36]
yield very precise measurements of activity in isolated pseudo- and acetylcholinesterase systems, and enable us to evaluate the significance of even minor variations in activity due to small constitutional changes in a series of molecules.

We are aware of the fact\_that the effectiveness of-a-psychopharmacological agent in vitro cannot be interpreted as evidence for the involvement of:the-specific enzyme in the mechanism of psychotomimetic-responses. Yet even without conclusive causal connection, this approach may furnish valuable information on the nature of psychopharnacologicalagents

It is felt that this investigation may yield (a) information assisting-the elücidation of interrelationships between molecular constitution and biological response, (b) bctter insight into the biochemical characteristics and therapeutic potentialities of certain types of moieties, (c) several series of new organic compounds and information about their physical characteristics, and (d) data-supplementing our knowledge of the neurochemical processes associated with the:action of-psychopharmacological agents.
\*k\*

The references cited in-the first paragraph of the outline are listed on the following page, \*kk

January 22, 1960

109-16

Page Six

[PAGE 37]
-1. First Annual Report to-the June 1955,

Second 2. May 1956, Annuar Rep to the

Fourth Report to the 4 May 195

5. Fifth Report to the

Ixth Report to the ay 1959

Seventh Report to the 7. May 1960 inpreparation).

g, Chem., 21: 799, 1956

9. . 0rg, Chem., 21; 805, 1956.

J. Org. Chem., 21: 958, 1956. 10.

11. J. Org. Chem., 22: 837, 1957.

12. Intern. pharmacodynamie,

J. 0rg. Chem., 23: 1577, 1958. 13. J.Org:Chem.,-23:-2005, 1958. 14.

Pharm. Assoc,, Sci. Ed., 15 48: 345, 1959.

Abstracts, Am. Soc.-Pharmacol. 16.

17. Nature, 184: 1922, 1959.

Sastry, J. med. pharmi-Chem.,-2:-in press, 18 1960.

19.4 med. phara. Chem., 2: in press,-1960. 109-2

109-16

Page Seven

[PAGE 38]
PROPOSED BUDGET FORRESEARCH PROJECT SUPPORTED BY THE (December , 1962 through November 307 1963)β

Project Title: The Synthesis and Biochemical Evaluation\_of Potential Psychopharmacological Agents.

Principal Investigator: of the Department of Pharmaceutical and Medicinal Chemistry, College of Pharmacy.

Personnel (Associates, Assistants-and Consultants)

\$12,000.00

Supplies and Materials

\$4,890.44

Travel

\$600.00

SUBTOTAL

\$ 17,490.44

7% of Personnel Budget (\$ 12,000,00 ); to cover retircment, etc.

\$840.00

SUBTOTAL 11

\$18,330.44

15% of Subtotal 11 (\$ 18,330.44 ): to cover participation in -indirect costs

52.749.56

.TOTAL

\$21,080.00

Checks should be payable to the

May 31, 1962

109-2

[PAGE 39]
Branch Category Boravlor Predletion  Control(o)

Byntheate and ovaluatioa of Potential Paychophnrancologicel Cospcunds Item ClassificationUolaeelfied Project Title.

Crypto ClassificationUoclaastfied Project Crypto A

Project Engineer Branch Project No.

B Contract No.Bubyroject 109 Task No.

1 Date Initiated1 uly 1960 Type of Contract.

421,00 00Completion Date30. ovanber 1963 i

Purpos?: Bluctdation of interrelationbipo beteson noloculer conatitution and biological reugones of cheaical coapctrda of fateroat to T8). 5

Teruiial year of à basic blochealcel research.

Interrally gotorated in Tad by petd for special biviocically cctive couounde and baslo inforsatien on thoir cheracterization.

Status:

109-17

Date15 4oveuber 1962

ROCUIROEE/T S0URCYI

[PAGE 40]
Dear:

I certainly\_enjoyed talking to you this morning.

For your convenience, I am enclosing a copy of the proposed budget for the next grant period-(December. 1. 1962\_through.November 30,1963).

With the very test regards,

Enclosure By Air Mail

P.S.:: My home address is:

file i MRUCTRA sub 109-18

May 31, 1962

1862

AMERICA'S LAND-GRANT UNIVERSITIES CELEBRATE A CENTURY OF SERVICE

1962

[PAGE 41]
Ph:D...Professor and Chairman of the Department of-Pharmaceutical and Medicinal Chemistry, College of Pharmacy.

[PAGE 42]
PROPOSAL FOR FSTABLISHMENT.OF FACILITIES FOR PSYCHOTOMIMETIC DRUG TESTING

First Year:

Survey of promising compourds

Literaturo review

Visits to sources, seninars

"Practice" trials—reproduce established results

Effects to be-sereened:- convulsants anticonvulsants specific arterial dilators - constrictors - antiserotonin\_effect cholinesterase-inhibitors sympathomimetic-parasympathomimetic

BUDOETINITIAL-STAFF

Neurologist : principal\_investigator
Clinical pharmacologist
Resoarch assistants
Statistician services\_(part time)
Resident asslznments=(8\_mo.=\$300/mo.)

Equipment and supolies e.g. calculator,-camera, E.E.G. service, computor service

Travel

To the budget figuras must-beadded 7% of personnel budget for retirement and 15% of cverall costs-for overhead.

\$3,000 11:,000 10,000 1,200 2,100

109-18

[PAGE 43]
FACILITIES FOR PSYCHOTOMIMETIC DRUG TESTINO (CQNTINUED)

Second Year:

Trials of now conpounds

Screening potentially valuable effects

Chronic toxicity in animals

Human trials - doublə blind-and/or concurrent trials: psychological effects autoromic effects anticonvulsant antispasmodic anticholinesterase (limited, on myasthenia grevis patients) antiserotonin ("cluster" headaches) 1

BUDGET- SECOND YEAR STAFF

Neurologist - orincipal investigator
Clinical pharmacologist
Exoerimental psychologist
Research assistants
Statistician sərvices
Clerk-statistician
Resident assignmonts

(+ 7% personnel for retirement) (+15% overall for overhead)

It may be advisable also to-consider the addition of a basic pharinacologist to the staff in second (or third) year. .1

109-18

\$-3,000 1,000 10,000 10,500 1,200 3,000 3,600 5,000 400 \$50,700

[PAGE 44]
Dear Sirr-

Enclosed-is the cumulative annual expenditure report on your\_grant\_to Dr. This is for\_the\_period July 1, 1960,-to: November-30, 1961

1862

AMERICA'S LAND-GRANT UNIVERSITIES CELEBRATE A CENTURY OF SERVICE

1962

[PAGE 45]
Budcet Report on ResearchFrojectsucported by·Th at (Ju1y1, 1960\_through\_November30,196t)

Froject Title: The Synthesis-and-Biochemical Evaluation-of Potential Fsychopharmacological Agents C

Frincipal Investigator: Fh.O., Frofessor and Head of the Department of Pharmaceutical-and\_Medicinal\_Chemistry,-College\_of.Pharmacy\_

Date: November 30, 1961

Outstanding\_Unencumbered Appropriation-Payments-ErcumbrancesBalance

Personnel: Frincipal Investigator: \$-3,000,00\$3,000.00\$-0----\$--0- Associates,Assistants&Consultants1-077.001;077.00 -0--0-

7% of Fersonnel Budget; to cover Ret.-Soc.Sec.-Ins.

15% of Entire Budget; to cover2;749.562,749.56-0- Indirect Costs

I have exaninod and approved the subnitted expenditúres.

Dato: 3/2/42

[PAGE 46]
MEMORANDUM FOR: The Record

SUBJECT: MKULTRA, Subproject 109, Cost of Equipment Exceeded Budget Estimate

1.The\_Budget Proposal for Subproject 109, dated 22 January 1960, had a proposed figure of \$5, 000. 00 for supplies and materials. There was no anticipation of any equipment.

2. An accounting report has been received for the period 1 July 1960 through 30 November 1961.  This report reflected expenditures of \$7, 061. 55 for supplies and materials, and \$6, 324,93 for equipment. These amounts exceeded the figurès in-the original proposed budget.

3. This equipment was expendable and the expenditures have-the approval of TSD/RB as being essential for the successful completion of the research work-that was conducted.

109-20

29 March 1962

[PAGE 47]
Enclosed is the curulative annual expenditure report on your grant to Dra This is for: the period July 1, 1960, to November 30, 1961.(

109\~21

March 9, 1062

[PAGE 48]
Cost Account 2125-1390-3902

Object Class

(When Filled In)

[PAGE 49]
Date:\_a Novamber 1961

MEMORANDUM FORTHE COMPTROLLER

ATTENTION Finance Dviaion

SUBJECT : MKULTRA, Subproject109

Under the authority-grsoted in the pemoraaduna datod 13 Aprit 1953

from the DCI to the DD/A, and the -extension of thio suthority in aubsequont

memoranda, Subproject=109 haq been approved, and:\$25,043.20

of the over-all Project MKULzRA funds have heea\_obligated to\_cover the

subproject'g expenses anó should ba charged to cost center 2l25-l390-3902

TSD/Rəsearch-Branch.

APPROVED FOR OBLIGATION OF FUNDS:

Date:\_

109.21

Researcà Direstor

[PAGE 50]
:TSD/Budget Officer

SUBJECT

:—MKULTRA,-Subproject 109, Invelea No. Al1otmoat No. 2125-1390-3902.-

l. Iavoice No. l covering the abovo eubprofect ls attached, Paymcat-shoald ba roada as follows!

Caabior'a check ln the amopnt of \$24. 080.09.. drawi on aw

Cashisr's check ia ths amount of \$963.2o,. drawa oA a n

Each check should bo made payable to the

2. Piease forward thé checka to Chief, TSD/Research Branch through TSD/Budget Officer by 28 November 196l.

3.  Thie ls a final involee. However, since it is anticipated that addltional luads will be obligated for this project, tho ftles should aot bo closed.

109-22

13 November 1961

VIA

MEMORANDUM FOR: Chief, Flaascé Division

[PAGE 51]
Receipt is hereby acknowledged for the following two checks:

Cashier'B\_Check No. #dated November. 30, 1961 B B. the anount of \$24,080.00, payable to on E

Treasurer's Check No. Hated November 29, 1961n
in the amount of \$963.20, payable te dravn on

109-22

RECBIPT

[PAGE 52]
MEMORANDUM FORt Chof, Finance Division

VIA :TsD/budgot officer

SUBJECTMKULTRA, Su5project 109,Iavolce No. 2 Allotment No. 2125-1390-3902.

1. Iavoice No. l covering tho abovo cubproject is attached. Paymoot ghould be cade ae followa:

Casbior'a check la the amount of \$24, 080. 00, drawn on

Caobier'4 check lo the smount cf \$963.20. drawn n

Each chock shouid bo nrade payable to thog

2. Piease forward the checke to Chief, TSD/Rcsoarch Branch through TsD/Budget Officer by 28 Novembor 1961.

3. Thie le a fnal lavolce, Howovor, slace it is anticipated that additional funds vill be obligated for this projoct, the filos should not bo closed.

Attechmeat: Invoice & Corti(lcatloas

Dietributiont Orig. & 2- Addrepsoe 1--TSD/FASS √2=-TSD/RB

1961

104-22

13 November 1961

[PAGE 53]
CERTIFICATIONS

#1 111 5t tz bersby sevtißed thas this is laveiem. applies to Sub-projeet No. 109cf MKULTRA, that perlermanse is sstisfactozy. that servises are boiex accomplished un acccrdancs with metval agreemeaks, Piat à dekailed agenda cf the payteats-and receipts ia cn Hle in TSD/8B, that this báll is just ard cerrect aad thas payment thersèf bas aot yet becn inkde.

Chici, TSO/Research Branch

13 Novomber 1961 Date

12) A is bareby certfed that this invetee apphiss to Subprojeet  l09 of MKVLTRA siuich waa duly approved. and that the project is being. saraed put ia -ascerdance with the-mecoorazdam cf 13 Aprl 1953 frora 15s JC. 19 the VD/A. and the extensicn of thie authoriry in subscqueai

109-23

Fer Sarvices

INVOICE=

\$25,043.20

Research Dirhctcr

[PAGE 54]
MEMORANDUM FOR: THE RECORD

SUBJECT :-MKULTRA, Subproject 109-

1. The purpose of this subproject is to provide funds for
the continuation of a study of potential psychopharmacological
agents. In particular, studies will be directed to the elucidation
of interrelationships between molecular constitution and biological
response. Studies will be conducted into the biöchemical charac-Chemiral

teristics of certain types ofmoieties which are of interest to TSD/RByn Criyi gmt it pry  te deelp BB meens to antiel Ihmmen Behailnn. 2. The attached Budget indicates the extent of the investi-

gations that will be carried out under the direction of Dr. B The in facilities available at the
funds for this project will be transferred using the as a cutout./ For administrative
purposes in this project, the salary of the prinçipal investigator, C
Dr. will be carried as a separate budget item and will be
paid directly to him by the cutout.

109-24

DR AFT 2 November 1961

[PAGE 55]
A \$. The cost of this program for a period of one year will not 21.080.50 exceed \$24. 080, 00 to which must be added the four per cent fee to the 21,923.20 making the total amount \$25, 043.20. Charges

4.The requires that the submit to them a summary accounting on an annual basis of all monies received from the Also, unexpended funds will be returned by the as soon as possiblę upon the close of the grant year.

6 5. A requirement for a six months' informal accounting on the part of the principal investigator is waived.

76. It is not anticipated that any permanent equipment will be needed for this program.

6 7. In connection with travel under this project, it is agreed that the Agency willaccept the travel documientationand accounting which conform with the practices of the

8. It is agreed that technical reports reflecting the progress of the research program shall be submitted at mutually acccptable intervals.

109-24

2

[PAGE 56]
/)g.: All personnel connected with the planning and monitoring

of this program possess TOP SECRET Agency security approval.

10. This project wil be unclassified after it leaves the

APPROVED FOR OBLIGATION

OF FUNDS

Research Director

Date:\_

Attachment: Proposal-& Budget

Distribution: Original only

109-24

3-

[PAGE 57]
PROPOSED BUDGET FOR RESEARCH PROJECT SUPPORTED BY THE AT (December 1, 1961 through Novembe: 30, 1962) β

Project Title:-The-Synthesis and Biochemical Evaluation of Potential Psychopharmacological Agents.

Principal Investigaton Ph.D., Professor and Head of the Uepartment of Pharmaceutical and Medicinal Chemistry, College of Pharmacy.

109-29

[PAGE 58]
ph.D.. Professor and Head of the Department of Pharmaceutical and Medicinal Chemistry, College of Pharmacy.

\$ 3,000.00

October 2, 1961

109-29

[PAGE 59]
SECRET

Date:2 Novovber 1961

MEMORANDUM FOR: THE COMPTROLLER

ATTENTION

: Financa Divioion

SUBJECT

: MKULTRA, Subproject 109

Uncer the authority granted in che memorandym Cated 13 April-1953-

fron the DCI to the DD/A. and the extonsica ot-this guthority in eubeequent

memoranda, Subproject109hias besn-approved, and \$25,04J.20

of the over-all Projoct MKULTR/ fuds havo boen obligated to cover the

subprojcct's expenges. end-ohouid be-eharged to.cost center 2125-1390-3902

APPROVED FOR OBLIGATION OF FUNDS: :

Date:

SECRET

109-24

Regearch Director:

Diateibutioa:

Original & 2 - Addressea

1- TSD/FASS 2-TSD/RB

[PAGE 60]
Janvary 4,1961

[PAGE 61]
BUDGET REPORT ON RESEARCH PROJECT

SUPPORTED BY THE AT (July 1, 1yo0 through June 30, 1961)

Projoot Title: The Syntheais-and Biochemical Eveluation-of Potential Psychopharmacological Agents. C

Principal Investigator: Ph.D., Profossor and Head of the Departmont of Pharmaceutical and Medicinal Chemistry, College of Pharmacy.

Datet December 31, 1960.

APPROPRIATIONPAYMENTS OUTSTANDING UNENCUMBERED ITEM ENCUMBRANCES BALANCE

Porsonnel - -0-\$1,500.00 Prinoipa1Investigator:\$3,000.00\$-1;500.00\$ Associates, Assistants and 9,000:00-1;000,00 -0- -8,000.00 Consultants:

4,890.4413.50 -0-4,876.94 Supplies and Materials::

Travel:

SUBTOTAL:

\$17,490.44\$-2,635.58\$-\$14,854.86

7% of Personnol Budget;.to cover insurance, rotire ment, etc.t

15% of Entire Budgot; to cover.participation in indireot costs:

TOTAL:

\$21:080.00 3,232:17 -0- \$ 17,847.83

Adm.Asst.-to-the-Vice=President

109-25

[PAGE 62]
The first quarterly grant io aid check for Dr. research should be forwarded. Each quarterly payment is \$5, 270.00. Quarterly paymente are-due on July 1, 1960; October 1, 1960; January 1, 1961; and April 1, 1961.

[PAGE 63]
109-26

Cost Account 6225-2029: /902

Object Class

[PAGE 64]
MEMORANDUM FOR:COMPTROLLER

ATTENTIONFiaaace Division

SUBJECT :=MKULTRA, Subproject No.\_109

Under the autbority granted In the Memorandum dated 13 Aprii 1953 frem the DCI to the DD/A, aad the exteaslon of this authority la subusqueat memoraada, Sabproject l09 has been approved and \$21, 923.20 of the over-all Project MKULTRA lands bave boen obllgated to cover the aabproject'd expensee and mhould be charged to Allotment 0525-1009-4902.

Chlef TSs/Chemlcal Divlaton

APPROVED FOR OBLIGATION OF FUNDS:

CERTIFY THAT FUNDS ARE AVALNALR ONIGATON REESENCES CGEO AUTR

Dato:

Diatributlon:Orig t 2。 Addreslae1-TSS/OC1TSS/FASB2-TSS/CD

TSS/CD/(19 Feb 60)

AUFOTGORCER

109-26

19 Fobruary 1960

[PAGE 65]
SECRET

1 Auguot 1960

MEMORANDUM FOR: CHIEF,PINANCE DIVISION

VIA : TSD/Budget Olflcer

SUBJECT LMKULTRA, Subproject fl09, Involce #1 Allotmeat 0525-1009-4902

l. Involce fl coverieg the above subproject la attached. Payment should be made as follows:

Casbler'a check in tbe amount of \$21, 080, 00, drawa on a

Caeblor's check ln tho amount of \$843.20, drawn on

Each cbeck should bo made payable to tho

2. Pleane forward the checks to Chief, TSD/Ronearch Branch through TSD/Budgat Officor by 15 August 1960.

3. Thie in a flnal tavoice, However, aince it is anticipated that additlooal funde will be ebligated for thls project, the files ahould not be closed.

A TSD/Regearch-Branch

Attachment: Invoice & Certificatiocs

Diatributioa: Orig. & 2 - Addreasce A-TSD/FASS 2-TSD/RB

CERTRFY THAT PUNOS ARE AVALASLE: CNUGAHOHACLETEN.1731 C0525-1009-4902 AUTHORRING OFAC.

109-27

CFAFEY

[PAGE 66]
RECEIPT

Receipt ia hereby acknowledged for the following two checks:

Treasurers Check No. dated Auguat 11. 1960 in the amount of \$21, 080.00, payable to , drawn on

Official Check No dated Auguat 1l, 1960 in the B
amount of \$843. 20, payable to drawn on

109-27

[PAGE 67]
MEMORANDUM FOR:CHIEF, FINANCE DIVISION

VIA

:-TSD/Budget Offlcer

:- MKULTRA, Subproject f109, Iavoice 41 SUBJECT Al1otment 0525-1009-4902

1. lavolce fl covoriag the above subproject is attached. Paymeat should be made as followa:

Caeblor'e check io the amount of \$21, 080.00, drawn on a !

Cashlor's checkin the amouat of \$843.20, drawn on B B

Each check should be made payable to th —…

2. Pleaue foyward the checke to Chiel, TSD/Rorearch Branch through TSD/Budget Offlcer by 15 August 1960.

3. Thia le a final lavolce. Howaver, elace it la anticlpated that additional funde willl be obligated for this project, the files should not be cloged.

Attachment:

Involce & Certificatioos

Diatributioa:

Orig.& 2 - Addressee

1- TSD/FASS

2-TSD/RB

109-27

1 Auguet 1960

[PAGE 68]
CERTIFICATIONS

(1) It is hereby certifled that thie lo Iavolce fl applying to Subproject 109 of MKULTRA, that performance ls satlsfactory, that servicee are being accompllahed lo accordance with mutual agreemante, that a detalled agenda of the paymente and recolpte is on file in TSD/RB. that thls bill le juot and correct and that payment thereof bpe not yet beea made.

Chlef, TSD/Reeearch Branch

Date:\_

(2) It lo heroby certified that thio involce applies to Sobprojact No. l09 of MKULTRA which wae duly approved, and that the project ls being carried out lo accordance with the memorandum of 13 April 1953 from the DCI to the DD/A, and the extenelon of thie authority ln eubaequent memoranda.

INVOICE

109-28

For Services :

Research Director

Date:

[PAGE 69]
19 Febreary 1960

MEMORANDUM FOR: COMPTROLLER

ATTENTION : Fiaance Divlelea

SUBJECT :-MKULTRA, Subprojoct No. 109

Uader the authorlty granted in the Menorandum dated

13 April 1953 from the DCI to the DD/A, and the pxtenaion o( thle

authority io subsequeat memorands, Subprojoct l09 kas been

approved and \$21, 923.20 of the over-all Project MKULTRA luode

bave been obllgated to cover the subprojact'a expecees and"

ehogld be cbarged to Allotmeat .0525-1009-4902.

APPROVED FOR ORLIGATION

OF FUNDS:

Reaearch.Dlrector

Date:

Distribatlon: Orix & 2 - Addressee 1 - TSS/OC 1-TSS/FASB 2-TSS/CD

109-28

TSS/CD/ (19 Feb 60)

[PAGE 70]
MEMORANDUM FOR:THE RECORD

SUBJECT :=MKULTRA, Subproject 109

1. The purpose of this subproject is to provide funds for tnli

a study of potential psychopharmacological agents. In particular,
studies will be directed to the elucidation of interrelationships
between molecular constitution and biological response. Studies
will be conducted into the biochemical characteristics of certain TS0/C6
types of moieties which are of interest to TSS/CD. 7

frlyt 2.The attached propbeal indicates the-extent of the investi-

gations that will be carried-out under the direction of Dr
in facilities available at the The funds for
this project wili be transferred using the as a cut out.

3. The-cost of this program for a period of one year will not 24050.00 exceed \$21, 080. 00 to. which must be added the four per cent fee to the 25,093.20 mnaking the total amount \$21,923.20.: Charges should

be made against Allotment No. 0525-1009-4902. 4. The equires that the

lsubmit to them a summary accounting on an annual basis of

109-29

DRAFT 19 February.1960

[PAGE 71]
all monies received from the Fund. Also, unexpended funds will be returaed by the as soon as possible upon the close of the grant-year.

5.A requirement for a six months informal accounting

on the part of the principal investigator is waived.

6. It is not -anticipated that any permanent equipment will

be needed for this program.

7. In connection with travel under this project, it is agreed

that the Agency will accept the travel documentation and accounting

which conform with the practices of the

8.It is agreed that technical reports reflecting the progress

of the research program shall be submitted at mutually acceptable

intervals.

9. All personnel connected with che planning and monitoring

of this program possess TOP SECRET Agency security approval.

10. This project will be unclassified after it leaves the

APPROVEDFOR OBLIGATION OF FUNDS:

ss/Chemnical Division

Date: 29155

Attachment:. Proposal & Budget,

2-

104-29

109-1

Distribution; Original only

[PAGE 72]
Project Title: The Synthesis and Biochemical Evaluatlon of Potential Paychopharmacological Agents.

Professor and Head of the Department Principal Investigator: of Pharmaceutical and Medicinal Chemiatry, College of Pharmacy.\*

Personnel - \$3,000.00 Principal Investigator Associates, Assistants and Consultante \$ 9,000.00

\$5;000.00 Supplies and Materials

Travel \$600.00

\$17,600.00 SUBTOTAL

7% of Personnel Budget-(\$-12,000.00); to cover insurance, \$840.00 retirement, social security, eto.

15% of Entire Budget (\$ 17,600.co); to cover participation \$=2,640.00
in indirect costs \$-21-080.00
MYMAT

Checke should be payable to thel

January 22, 1960

\* Effective July 1, 1950

101-29

[PAGE 73]
PROPOSED BUDGET FOR RESRARCH PROJECT SUPPORTED BY THE AT THSC (July 1, 1961 througa Juno 30, 1962) B

Project Title: The Synthosis and Biochemioal Evaluation of Pptential Peychopharmacological Agonte.

Principal Investigator: Ph.D., Profoseor and Head of the Dopartmont Pharsicsutical and Medioinal Cheaietry, Colloge of Pharmacy.\*

Checks should be pajable to the

January 22, 1960

\* Kffoctive July 1, 1960

109-29

[PAGE 74]
Project Title: The Synthesis\_and Biochemical Evaluation of Potential-Psychopharmacological-Agents.- C

Principal Investigator: .D., Professor and Head-of the Department of Pharmaceutical and Medicinal Chemistry, College of Pharmacy.\*

Personnel-

Supplies and Materials

7%of Personnel Budget (\$ 12,000.00); to cover insurance, \$840.00
retirement, social security,etc.

15% of Entire Budget (\$:17,600.00); to cover participation in indirect costs

January 22, 1960

\* Effective July 1, 1960 (on leave of absence-July 1;1960 through June 30, 1961)

[PAGE 75]
S.RORBT

Poto of Crigizal Pericé Too Ectsaded Alletent AsSant ct Covaed Suter

"ARtoal Pericé Tiae Erzerded - Allotrunt ánqunt of Auchcrisaticps Cbliation 2.m6 3.02 1125119296211010.30

relaaeo Qul tt 821923.20 92320
Cud2d1-13112504320 0
351602081081.2 12320 dwo. ts 0.De.1 2123320

109-30

F.CAT?

[PAGE 76]
ADDITTONAL COPTES OF THE PROPOSED BUDGET FOR T96I-62