[PAGE 3]
O

RECEIPT

I hereby acknowledge receipt. of the following check:

Treasurer's Check No. 1/42433, datod-April 4, 1956, in 王 the amount of \$103.00, drawm on thek payable to the mmre B

Dato 10 apr st6

0

55-3

[PAGE 4]
I hereby acknowledge receipt of the following check:

Treasurer's Check No, 202958, dated April 4, 1956, in the, amount F of 2, 700.00, drawn on the ,payable to th

Date 10apr

RECEIPT

[PAGE 5]
1xunrA Cubrroloat 55. Tavoioo 1
A15tnont 6-202-10-601

ment shoula bo mde ss folloue:

Coeticete chool in tho aaouut of ca700.00 dran on an lank. E auaxera dnsek in tus amt or 103:00 dra on a tack.

B Poth chooks shoull ba made payahlo to the

2.  The above cheaks shoula bo\_fovorded to Chief, Tss/Chesical Diviaiea, througa Tos/budget Offloer,-no later-than 3 April 1956..

3. Thuls is a final invoiee. A total ot €2s03.00 vas obligated mder this subprojeot during FY-6ó.Rouovce, cince it ia anticirated that edditional fonas will be obligated tos thio projeot, the filca phould not be closed.

C53J70T:

21 1arch 1956

PILANGZ DI/ISTON

2C3/Sedget Crficor..

[PAGE 6]
CERTIFICATICNS

(1) - It is heroby certificã that this is Envoieo 1 applying to ICbla Subprojeet 55, that performanee is satiofaotory, that thn eravices are being acccapliched in accordanco with mutual agrocsonts, that a detailed agenda of the payuents and roceiyts is on cilo in Tss/Cd, tuat this biil is just pnd oorrcot and that payment theroor hao-not-yet-been-nade.

Chief. TOs/Chenical Division

Date:

(2) It 1s hereby certified that this invoico applies to MOUUIRA Sutprojeet 55, uaieh vas duly. approvea,uxi-that, the project is being carried out in eccordance wità, the Fenorardum datei 13 April 1953, Cron the DOI tothe.ID/A, and the extonsion of this.authority. in subsequent nenorarda.

Research Diroctor

Dater

IIVOICE

62808.00

[PAGE 7]
Galer the astcriig gone-l in the Pecorcatun dated 13 épril. 1753 Srea the Dor to the Do/e, snd tho estenaiou of thia authority in sabs-puent nssoronda, Sabpropoot 55 lss beea epproved, and i2od.00 of tho over-all Fzojest laJbEl foda hao beea obtigated to coves the clpooject’a enetsea and shquld be chorged to Allotnent 9-2502-10-001.

APFRCV:2 FCR COLIV4TION C TU 0SI

BIDREY GCTTLIEB Chiar Tes/Onmaical Divisica

LCUTE: THAT FUNES AC= A3IE C157

DatetEs

21 Pabrwary 1250

LOA FGA

ont

[PAGE 8]
SUBJEOT :Project 1RULTRA, Subproject 55

1. Subproject 55-i5 being initiated to enable Dr. to undertake pharpacological studies of interost to TSs/co. Departinent of is located ats B B

2. The scope of the projoct will embrace the relationship between chenical structure-and:biological-activity of various isoquinoline derivatives and heterocyclic compounds containing two or more ring systess.h C

3. The School and Dr.  are conpletely unvitting of Agency intorest:in this-proposed program. Therefore, in order to maintain cover,

(a) the requirement for a-Memorandun of Agrcement with the principle investigator will be waived,

(b) the will request Dr. to obtain on accounting from the University upon completion of tho program year.

4. The cost of this program for a period of one year-is-estimated to be 2,700.00.To this sum\_must be sdded 108.00 representing a four percont service-charge by the  thorefore the total cost will not exceed 2803.00.Charges should be made against A11otment 6-2502-10-001. B

5. Title to any permanent equipient purehased by funds granted the University shall.be retained by the University in lieu of higher overhead rates.

Downgraded to: ty authorfty of: 187475 cate: June 1977

E? IMTDET; CL BY 187475

DRAFT/A

21 February 1956

MEMOFANOUN FOR: THE RECORD.

Coxnmoded to: m EEPOET:CL BTETIVS

[PAGE 9]
CL BY -187475 -EA LSTDER;

6. Documentation and secounting for travel expenses which are reimbursable by the University shall conform with the accepted practices of that institution.

APPROVED:

[PAGE 10]
Gentlemen:

The undersigned would like to apply for a yearly grant beginning
February 1, 1956, for 2,750.00 for a reseerch project to be carried out
in the Departnent of n

The purpose of the study is-to-discover the pharmacological effects of certain groups of coupounds prepared by Dr. and associates of the Department of In other words, we want to take a further step into the most basic aspects of pharmacology--biochemorphology,or the relation of chenical structure and physical propertiesof new chenical compounds to biological activity.: We propose to test the following compounds :

a. Various synthetic isoquinoline derivatives.

b. Heterocyclic compovnds containing two or more ring systens.

It is highly desirable to accumulato-pertinent data on all these types of new compounds for the treateent.of disease as well as for tho advancement of science itself.

These compounds will be tested on the:

a. Central nervous system.-

b. Autonomic nervous system.

c. Sensory nerves.

d. Sensory nerve ends.

e. Somatic motor neurones.

This elassification, of course, ineludes drugs such as those producing hallucinations, tranquilization, sedation, anosthesia, adrenergic and cholinergic effects, and general and locel analgesia. In addition, the compounds will be tosted ac to their effect on the smooth muscle itself and on possible antegonism to bistamine.

B 55-8

January 26, 1956

A

[PAGE 11]
I propose that the following budgct be provided for the project:

\$ 275-Overhead for the University

1,700 - Salaries

250-Travel and administration

525- Animals, chenicals, and miscellaneous equipnent

2,750TOTAL

Mex I add that this gront uill bo\_a further step in the cooperation between the Departments ofr and at the B

Doctors e and will be periodically informed as to the

MARUNGE

SCNSITIVE INTEILIGENCE

[PAGE 12]
2 Suo 55

Bate et Crigtnal Fartos Alletrant Asqvat oo fut Cつ 23 Feb 56:1yeev 6-2.503-10-001 2508.00