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Reference is made to the memorandum of 3 Narch l952 fron concerning this subject.

From the substance of the attached report it appears that the exploration for new wonder drugs, new scientific devices, new chemicals and other related means have not, on the basis of present exploration, produced any guidance or inforation vhich is of practical value to our Project. It is believed that the negligible results have been Lrom the following factors:

(a) The exploration mission by OSI has not been properly thought out nor sufficiently specific; with the result that they have wandercd through a tremendous field of science without a definite mission in mind.

(b) OSI has been looking within the scientific field for one means which will be the answer for ARTICHOKE, when in all probability no one means will bé the answer but a series of elements may contribute to a satisfactory ARTICHOKE approach.

(c) The OSi approach has been purely scientific and not operational, with the result that we are "putting the cart before the horse" in this program.

It is my feeling that scientific exploration of this field for ARTICHOKE purposes is highly necessary and that this could be a continuing project with OSI. From timc to time we might initiate or subsidize certain types of research which do show unusual potentiality.

On the other hand, I still feel that I&SO is pursuing the right line , namely, the combination of drug and hypnosis. We are driving at operational use not new discoveries in the scientific field. We may, from the OSI viewpoint, be using old tools; however, if we perlect their use we will be achieving much more operationally than establishing a large library of intoresting scientific reports. It is, therefore, my recormendation that we pursue our line of activity to the greatest extent possible and directly interview sourcesof information ourselves to obtain guidance, inforration and backing on the straight operational approach as we see it. To this end, we should as a consultant ani be prepared to use him operationally pick up as the occasion demanis. In addition, we should use a doctor from Medical Staff for operational use and research as directed, and ifis

A18,4;23/33

TO: Security Officer/CIA

8 March 1952

FROX : Deputy Security Officer/CIA

SUBJECT: ARTICHOIE.

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unwilling to supply a doctorrdr this purpose we should obtain our own doctor. We, at the same time, should coordinate with O3l from the standpoint of general scientific research.

What we basically need is practical application against straight
operational cases. After the establishment of a competent team using and.a medic, we should seck from the branches difficult
operationalcases for tean use and endeavor to perfect our technique.
In this line, nothing succeeds like success and if we can crack open
one tough case we are well on the road to verifying our theory. 4

A