[PAGE 1]
XIVOTCE CUECK LIST

MULTRA Supjct

AC Date of Criginal Period  Tire Extendeä Allotzent leount of Authorization Covere1-To Munder Ogligation

[PAGE 2]
Purpose: To support, in part, a stuly or the cocputer analysis af bicelectrio respoaso petterne (MIRA 129).

Initietod: June 1961

Contractori as a granteo of

Coot: \$2;505.33

Status: Cooriencing.

[PAGE 3]
On July 6, 196l, a gront vas made by thq in the amount of \$2,505,33, to surplenont york in progress at tha These funds were ezponded in payoent for the follow ang itengt

2 power auppliea Lnc. \$1,000.03
1 dermohmpneter, Yellow Springs Inotrwmencs Co. 890.06
beam evitching tubes & breacboards, Burroughs Corp. 190.99
wire and connectors, Graybar Electrio Co. 21.09
1 chair for experimental subject, Hecbt Co. 89.95
i parts cabinet, Ginn's 54.77
1 pulse-transformer, Freed Pranoformer Co. 19.10
dicdes, rosistors, Elcctronio Wholosalers, Inc. 94.62
capacitoxs, diodes, Capitol Radio Wholesalers, Inc. 77.55
tubing, resistora,\_Certified Blectronics, Inc. 6.02
IBH Part No. 1010671 7.30
dust control for magnetic tape unit 45.00

\$2,505.33

129-24

Total

TST/Lcal Div

[PAGE 4]
February 5, 1963

A Look into the Puturei Coaputer Techniquce for Peycho

Participantst

What is the future of data-rcduction instrunentation in the poychophysiology laboratory?

IThe SETAR (Serlal Evcnt Tiner and Rocordor) in thd sutonatic data processing of paychophysiologic information.

The effect of electronio ficea on revcarcn bchavior.

Analysis of physiologic response to film.

Codputer prograns for the analysis and synthesis of peychophysiologic dats.

Analog-to-digital conversion and rccording of ten uimultaneous data channela in digital computer fornat directly from the buman subject.

Recuction ot polarieation effects in skin concustance msaouronent.

Sinco our recearch may he of interest to you, wo would appreciace baving such furthor support fron you, as you decm eppropriate..

Sincerely yours,

129-28

[PAGE 5]
Your grant helped to suprort the following papers, symposia and publicatlonss

PUDLICATIONS

Recording physiological mcasurenents lor data proceseing

An 18M 1620 program for a xegression transtormation of paychophysiologic data.

reparing psychophysiologlc analog information for the digital computer.

Digltal Somcutox analyala of Faychophvoiolosic intormation

A high-speed constant-illunination tachistogcopo for autonatic pesusnciny of n stinula

Anonpotarraing, high-acourNcy skin-zesistanco transducer for digital convereion.

PAPERS READ DT PROFESSIONAL HEBTINOA

Ths control of human hehavlor by scienti1ic ncans.

129-2C

February 5, 1963

[PAGE 6]
letter explains the enclosure. After reading it, I would ogree thot it does "conform to the best current thinking on skin conductance, "

This\_is my\_only\_copy, We'll send journal reprints when available. Meanwhile, this bit may help some of your people\_who are thinking along similar lines.

Enclosure

November\_17, 1961

[PAGE 7]
Enclosed is a copy of a paper we are submitting for journal publication.

This equipaent was developed by us since a suitable instrument was not available comercially. It incorporatea the characteristics which we find most desirable for our system, and conforms to the best current thinking on sxin conductance.

Hope to see you soon.

November 8, 1961

[PAGE 8]
This instrument is axranged for analog-to-digital conversion and aubscquent recording on magnetic tape, and wao epecifically deoigned for this application. However, it can be applied with & variety of readout devicea.

The instrument described here incorporates several basic characteriaticsi. :

(1) overcomea the polarization effect at the electrodes by a continuous reversal of the direction of currcnt flowing through the subject,2

(2) an absolute value circuit nullifies anyjeffect which current reversal might have on the output,

(3) covera the total range or the subject'a resistance from O-4O0K:as-a single channel voltage output,

(4) a bighiresolution which permits discrimination of changes as small as onc part in 2,000. 1.

In practice, the resolving power of thie instrument is limited by the readout device coupled to its qutput. In its, present application

2 The initial suggestion for nullifying polarization effects by means of current reversals

A Non-polarizing, iigh-accuracy Skin Conduct ze Transducer for Digitel Conversionl 127-44

[PAGE 9]
this is one part in 2,048 of the reaistance range covered, which xepresents the maximua capability of an eleven-bit binary analog-to-digital converter with a plue or minus l0 volte input.

PRINCIPLE OF OPERATION

This unit utilizoe the constant current feedback circuit of an

operationel amplifior to dotormine the skin conductance of a subject. The I-R drop across a subject is calculated by a differential amplifier which algebraically adds the voltage at one side of the subject to the inverted voltage at the other side.

A multivibrator current-switching circuit is used to reverse the current flow through the aubject, thus preventing electrode polarization. Due to the current reversal through the subject, an  abeolute value cixcuit is added to keep the output of the dlfferential amplifier positive at all times.

The electrodes used with this inatrument are two zinc-zinc sulfate electrodes, 2 cm. in diameter, and mounted in lucite cups, and are attached to the volar surface of the aubject's left metacarpus and forearm.

The output voltage of the abeolute value circuit, when divided into
the constant subject current (5Oua), equals the subject's conductance:
GI. B

The subject current, which remains constant after being adjusted, is SOua. Thie current rcoults in an output voltage between O to 20 volts for resistanco readings of less than 400,000 ohma.

Each amplifier has a shorting switch and balance circuit in ity input, A front panel switch and meter are available to read the outputo of each

-2

129-4C

[PAGE 10]
amplifiex which can thereby be balanced individually without other test equipment.

Precision xesistors (1%) of 100,000 ohme, 30,000 ohms, 25,000 chms,
10,000 ohma, 5,000 ohas, and 2,500 ohms may be switched into the feecback
circuit of the constant current amplifier when calibration is deeired. APPARATUS

Constant Current Amplicier. The constant current amplifier conaists of a Philbrick K2-W operational amplifier, a Philbrick K2-P stabilizing amplifier, and associated fcedback and input registora. If it is not desirable to have a chopped DC current at 60 pulses per sacond through the Philbrick K2-P may be replaced with standard biasing resistors,  Great caro must then be, exercised in balancing this circuit.

The input circuit voltage divider uses a 10,000 ohm potentioneter to set the current flow through a 270,000 ohm input resiator. If the current flow through this resistor is set at 4Oua, then the feedback current flow through the 250,000 ohm feedback resistor, which connects to the summing point of the amplifier, will alao be 4Oua. Thia is duo to the feedback characterlatics of the operational amplisier. Forty mlcrcamperes flowing through a 250,000 ohm lcsistor will cause a ten volt potential to be present at the one megoha input reaiator of the inverter portion of the differential amplifier. Ten volts dropped across à one megohmiresiator produces a current flow of ten ua. The combinatlon of ths 4Oua current and the ten ua current both flow through the aubject. With the subject resistance at lcss than 400,000 chms, the current flow through the subject is 5Oua at all times. The input voltage to the mecond half of tho diffexential amplifior is then 50(ua) times the subjcct resistance plus ten volts.

3

129.48

[PAGE 11]
Assume the subject resistance to bo 100,000 chms, The voltage on the input side of the subject will be ten volts. The voltage on the outpuc eide of tho subject will be Sx10-5 amperes times lxl05 ohme, or 5 volts.

Kultivibrator Currcnt Switching Cixcuit. Tbis circuit consiets of a Philbrick X2-W orerational amplifier, a 6ALs dual-dicce, and associated capacitors and reeistors.

The K2-W is wired ae a typical multivibrator circuit with charge capacitors of 4mé, 0.4ms, 0,2at, and 0.lmf, wired to a front panel awitch, These capacitora causa the K2-W output to go positive and then negative at a rate of 0.l cps, lcps, 2cps or 4 cyclea per second respectively, depending on the switch position. A positive or negative going external synchronizing signal may be imposed upon tho multivibrator through a fitting connected to tho input grid. :

When the output of the multivibrator goos positive, plata 2 of the 6Al5 diode switch goes positive. This effectively causea a positive potential on the cathode of both dioden. Plate 1 of the 6ALs bas no current flov at this\_time becauso ito associated cathode in. positive. when the multivibrator\_swinga negetive, plate 2 of the diode becomes ncgative and thud cuts off. Cathodes l and 2 become negative due to the 300 volt voltage-divider network in thin\_circuit. Current then £lows from cathode 2 to plate 2, dorn tbrough two 270,000 ohm reaistors, and a 100,000 ohm balance potentiometer to gcound, A negative potential is eatablished at the junctlon of the 270,000 ohm diodc plata reaistor and the 270,000 ohm resistor which 1s connected to the halance

129-40

[PAGE 12]
potentioneter. This negative potential counteracts the positive potential at the sumaing point of the constant current amplifier and produces an algebraid sum of equal but oppoaite voltage. The current flow through the subject ia then 5Oua in the xeverse direction.

consists of two Philbrick K2-W operational amplifiers, two Philbrick K2-P stabilizing amplifiers, and ansociated feedback and input reeiatore. The K2-P chopper amplifiera are requisite to obtaining the desired accuracy and resolution. Each ampllfier has an amplification factor of onet Bout - Rf x Ein. The ten volts present-at the input side Rin

of the subject are invertod through the first ofithese ampliriers and
introduced at one of-the summing input resistors:of the second amplifier,
The voltage developed on the output side of the aubject is fed to the
other sumaing input resistor. The output of the:second amplifier goes
negative and positive as the current ie reversed through tho subject,
and bas a voltage value representing tho algebraic diffcrence between
the two input voltagest Bout  Rf x E1 + Rf x E2 Rin Rin

The output:voltage of the differontial ampllfiers has a range of -20 to +20 volts.

Absolute Value Circuit. The absolute value circait keeps the output positive at all:times,  Thia circuit consists of.two Philbrlck K2-W opcrational amplificro, two Philbrick K2-P stabilizing amplifiers, a 6AL5 dual-diode, a lN38A diode, aná asoociated resistors and capacitoro.

129.40

[PAGE 13]
1p applied through a 250,000 ohm input resistor and the equal negative voltage fron the firet half of the absolute value circuit amplifier is applied through a 125,000 ohm input resintor, :The resulting output from the second amplifier is a positive voltage equal to the positive output of the differential amplifier.

129-4E

[PAGE 14]
The plus or minug 20 voltg output of the differential amplifier

are applied to the 250,000 ohm input reaistors of: both amplifiers which

make up the absolute value circuit. If the output ie negative, the

output of the operational amplifier with the 6ALs switching diode in

its foedback circuit goes poaitive to the same value, The cathoce of

tha output diode is then positive and cuts off. The same positive output

1s also applied through a 50,000 ohm resistor to the plate of. the

feedback diode causing it to conduct, and thuo reduce the swming point

of the amplifier to zero volte. The l25,000 ohm input resietor to the

second operational amplifier ia kept at ground level by tho lN38A to

ground. With a feedback resistor of 250,000 ohma in the second amplifier,

it gives an output of some positive voltage equal to the negative input.

The resistance of the subject can be calculated by the formula

R = SOua x Bout. This is only true if the final amplifier feedback

resistance is 250,O0o ohms. If this value is doubled, the voltage output

muet be divided by twos or if halved, multiplied by two, etc,

If the output of the differential amplifier goes positive, the

output of the first amplifier goes negative and the cathode of the

output dlode goes negative. Thia negative voltage is applied to the

125,O0o ohm input resistor of the second amplifier as the diode plate

draws current. The neqative voltage on the plate of\_the feedback diode

cuts it ofe and only the 250,000 ohm fcooback resistor is in the

circuit. This causes an amplification of ono through the firot amplifier.

The input to the second amplifier is then composed of two ecual but

oppogito voltages.The popitive output of the differential amplifier

6

129-4F

[PAGE 15]
Cost Account125./396. 9962

Object Class

[PAGE 16]
DATS: 22 JEO 1901

MEXORANDUH FOR:TEZ COGTROLLER

ATLOFTON : Finance Division

SUBJFOT : MLERA, SubgroJeet 129

Under the authority grentsd-1n the. wasorardua dated 13 Ayril l953

froa the Dor to the PD/a. ani the oxtepsion of-thio-cuthority 1a-sub-

: sequent zsiorarãa, Subproject 122 has been ayprovel, era 2505.33

of the ovor-all Project kUaA funds bave bean otliseted to cover the

1125-13/0-3×2. aubprojeet's expences .end shoold da ebarged to coot centor

APPROVEO FCR OBLIGATION

I CERTIFY THAT FUNDS ARE AVAILABLE OBUGATION REFEROICE No
CHAROK 10 ALLOTMENT No.

Researea Diroctor

Date: 1HN

Distribution: Orig. & 2 -Addresaee TSD/PASS 2 -TSD/RB

AUTHORZING OFFICER

[PAGE 18]
Cost Account 1125:/009-1102

Object Class

A

(When Filled In)

[PAGE 19]
MEMORANDUM FOR: Chlef, Flnance Diviston

: TSD/Budget Officer

SUBJECT MKULTRA, Subproject 129, Involce No. 1, Allotment No. 1125-1390-3902

1. Involce No. 1 ts attached covering tha abovo subproject. Paymont should be tnade as followe:

Caabler's check in tho amount of \$2505, 33 drawn on payablo to the B

2. The check ahould be forwarded to Chief, TSD/Research Branch, through TSD/Budget Olficor, no later-than 17 July 1961.

3. Thie is a final invoice. However, since it is anticipated that additional funde will be obligated for this project, tho Giles should not be closed.

Attached: Involce & Certifications

Dlatributlon: Orig & 2- Addressee

RECEIVERT

129-8

6 July 1961

7032

[PAGE 20]
KENOPANDUA PORI COPTROLLES

AITNTIcd:Finence Divislca

BUAJECTMULTAA, SubproJect 129

Vader tha suthority granted 1a the aooorandua dated 13 Apr11 1953 froa the DCI to the D0/A, and the extonsion of this authority in eubeequent menorende, Subproject l29 hes been approved end 20,000 of the cver-all rav,A projeat funde has been cbligstod to cover the subprojeet'a 1 expenses. This obligetion of funds should be charged to Allotmont 1125-1009-1902.

APPROVED POR OBLIGATION OF PUNDS::

I CERRISY THAT FUNDS ARE AVAILABIE 27 OCT
ORUGATCNRE 1950EL3
CHAROE TOACT11075-1009 1182AUINORUTG ONTR

Research Director

Detei\_

2

Diatributionl Orig 6 2 --Addrcases 1 - TSD/0c >1 --TSD/FASS

388

129.9

24 October 1960

[PAGE 21]
9 Januery 1961

MHRANDUM FORt Coaptroller

AFEEMPIONI Pirance Divieion

SUAECTCancellatioa of NXULTRA Subprojoct-129

Heorandue dated 24 Octobor 1960, to the Comptrollor, approved HULRA Subproject 129 in the aoount of ↓20,000. Due to a change in plans on the part or the principol iaveatigator this projeot bos been corcelled ani the funds havo been returned tor uoe in other projecte.

APPROVZDT

Rescarch Director

Datai

Dietributioni

Orig. & 2- Addreeses

1 - TSD/FASS
2- TSD/AB

129-10

[PAGE 22]
RECEIPT

Receipt of the following check is hereby acknowledged:

Treasurer!s Check No, 184192, dated July 18, 1961, drawn on the

in the amount of \$2, 505. 33, payable to the

[PAGE 23]
CESTIFICATIONS

(t) .It ta berety certilied that thia is Lavotae l epply ne to acb-yrojee. As. 129 er pantsh, that perforannre 1s sstisfactory, tai sarvicts uee bel accosplished in secordaose with mcutual agreenerts. that a deteiled s.onoa of the payuents aod recoipts 1s on file in TSu/Rs, that thia bull 1o qus. and correet and that peyeot thereef has not yet beenract.

(at It ts hepehy certiried th s this invoice appiiea to RudProject 129. of sallin vhkss sea duly approved, ead toat the proceet is beiag carrted ot In sevordsace with toe meaoretiua of 13 April 1953 frce the Dei to the po/a. ond the extecpion ot thls euthority ia sutpequeut roaoceoda.

129-12

For Cervicea

INVOICE

\$2505,33

[PAGE 24]
6. Jaly 1961

MEMORANDUM FOR: ChieL, Flnance Divisioa

VIA :-TSD/Budgot Oflcer

SUDJECT

1MKULTRA, Subprofoct 129, Iavolco No, 1, Allotmeat No. 1125-1390-3902

L. Invoice No. l le atachod covoriog tàe above subprojoct. Paymnent should be made as followe:

Caebiar's chock in tha amount of \$2505. 33 drawn on a Espayable to the B

2. The check ehould be forwarded to Chiaf, TSD/Research Branch, through TSD/Budget Olcer, no later than 17. July 196l.

3. This ls a final lnvoico. However, since It is anticipated
that additlooal funde will be obllgated for thia project, the fllee
ahould aot bo closed. A

Attached:

Involce & Certi/lcatlons

Distribution:

Orig & 2- Addresaco

1-TSD/FASS

2.TSD/RB

129-13

[PAGE 25]
DATE: 22 JEO 1961

MOORANOUM FOR: TES COFTROLLERT

APEEÉTION

: Finsnce Divisioa

SUNJSOT

129 : LLARA, Sproject

Usder the autbority grented-tn tho mamoracdua dsted 13 April l953

froa the DOI to tha-DD/A, ant the-extension of-thls authoricy iu sub-

sequent resoranda, Subproject 129 hes bean epprovei, erd 2509.33

or the over-all Project NultlA funis-have- besa obligsted to cover the

1125-1370-3902. oubprojoct'à exqeneeo cnd shonld da chargod to eoat centor

Caier TSD/Reseorch Brench

APPROVED FOR OFLTGATTON C PORDS:

Date:

Distrlbution: Distrlbution:

Orig. 8 2 - Ad4rcnaoe 1-TGD/PASS 2- TSD/RB

129-14

[PAGE 26]
1. The purpose of this subproject is to support in part research studies in the computer analysis of bioelectric response petterns.- The work will be performed

2. The attached proposal, as submitted to the Research, covers the technicel scope of the project. The study i designed to determine the-single, relative and combined efriciency of nine separate indices of psychophysiological reaction in diecriminating various kinds of stimuli to the source individual. The investigation has potential for fundamental aspects of the significance of bicelectric signals, as well es for applied measuring devices, such as the polygraph.

has agreei to furd 3. the original proposal in ita entirety. Several additional iteme of equipment, neglected in the original budgel, are crucial to carrying out the investigation. These itema ere liated in an attached letter. In peturn for financing of this equipment, rhas agreed to keep us fully informed of his research progress and has indicated a willingness to modify his inquiries in any direction that would offer some benefit to the Agency.

4. The subproject will cover a period of one year and will cost \$2505.33 Charges ahould be mede against Allotment 1125-1390-3902.

129-15

22 June 1961

MEMORANDUM FOR: THE RECORD

SUBJECT :MULTRA, Subproject 129

[PAGE 27]
5. Funding for this subproject will be handled as a grant from the and accounting for the funds disbursed will follow the practices established for that organization.!

6. Title to the equipment purcbased sball remain vith the in lieu of\_overbead costs.

has been cleared through TOP SECRET and is witting of true sponeorehip.

APPROVED FOR OBLIGATION OF FUNDS:

Date:

Distribution: Original Only

ATTACEMENTS; Proposal & Budget

129.154

[PAGE 29]
129-17

Deny i0 TOTO

[PAGE 30]
Memorandum to:

Subject: Recommendation for Funding \$2,505.33

Bthat i In a ponicked telephone conversation on Friday, June 2 explained Rad failed to honor indebtedness to B which incurred by stransfer and recently purchased equipment also wenf to

The basic project will not bear the cost of previously expended funds, even though they cre vital to the conduct of the experimental work. This, then, creates an opportunity for "buying into" future work ot an Insignificant cost. He expresses a willingness to bend his inquiries in any directlon feosible.

I recommend that we provide this emergency fund foror future exploitation. :

Enc: 3

129-18

June 9, 1961

[PAGE 31]
9 Jannary 1961

NEHORANDUN PORI Comptroller

APEENTION ! Pinance Divieion

SUJCT Cancelletion of KULTRA Suproject-l29

Memorandua dated 24 October 1960, to the Coaptroller, epprovod nxULIRA Subproject 129 in the exount of \$20,000. Due to a change in plans on the part of the prinoipal invaatisator this project bas teen concelled ani the funda have beea returned for use in other projects.

APPROVED!

Resesrch Direator

Date:.

Distribution:

Orig. & 2 - Addressee 1 =TSD/FASS 2TSD/RB

129-19

[PAGE 32]
This is an initiation of a new project.

Purpose of Project: To finance a part of research on"Computer Analysis of.Bioelectric Response Patterns."

2: Project-Monitor:

FROM:TSD/RB

Room

129

TO: TSD/OC

[PAGE 33]
SUBJECT : MKULTRA, SubproJect 129

1.  Tbis subproject is for the purpose of financing a part attached proposal on "Cocputer Analysis of Bioelectric Response Patterns." The work will be perforwed at

2. The attached proposal covers in adequate detail the technical scope of the project, which is designed to determine the single, relative and conbined efficiency of nine separate indices of psychophysiological reaction in discriminating the significance of various kinds of stimuli to the source.The investigation has potential for fundamental aspects of the significance\_of bicelectric signals, as well as for applied measuring devices,-such as the polygraph. 73

3. is funding this proposal to the extent of \$27,500, which includes everything but We will fund the remaining \$20,000, which represents this salary item. The project will cover a period of one year, starting 15 November 1960. Charges should be made against A11otment\_1125-1009-1902.

A 129-21

DRAFT/QND8 21 0ctober 1960

[PAGE 34]
4. Although the

will provide a cutout function for passirg the funds on to

the project has been evaluated and will be monitored

solely by TSD/RB staff members. The funds will be given as a

and will be accounted for by B the normal procedures by whtch university grants are handled.

thas been cleared through TOP SECRET and is

witting of true sponsorship.

APPROVED FOR OBLIGATION OF FUNDS:

Date:\_

Distribution: Original\_only

129-214

[PAGE 36]
Proiect Titlet Computer analysis of bioelectric response patterns.

Principal Investigatort

Total estimated costr \$47,500. for 12 months

Proforred starting daterNovembor 15, 1960

Duration: 12 months

Brief: Nine separate indices of psychophysiological reaction will bo analyzed for their relative efficacy in discriminating stimuli of different arousal value to the source.Rapid and accurate evaluation of the psychophysiologic responses will be facilitated by\_conputer analysis of these data. \_A variety of phyeiologic, motivational and expectational conditions of the source, context settings, and types of stimuli will be tested to dotermine their efficiency in differentiating between critical and neutral stimuli.

Requirement

The ordinary interviewer is handicapped by his inability to determine-the kind of information carried by his infomant. Once the interviewer can obtain a trustworthy catalcg of information possessed by his.source, his power and skill usually enable him to elicit it. If the source can remain unaware that an index of his private nemories is available to the interviewer. it miqht prove an added advantage to the interviewer. This project proposes-to-devise the metbods which will placo listings of the sources' knowledge, with or without their awareness. into the hands of the intorviewers.

Approach

The study seeks to differentiate the reactions of sourccs to critical and neutral stimuli.  It is therefore necesgary to equate the stimuli in all aspects except their-aignificance and personal mcaning to the subject. There are several ways of controlling the personal significance of stinulit\_(a)-by conditioning. (b) by embedding the stimuli in a conflictual context, and (c) by an independent measure of the inherent arousal value of various stimuli to the subject.By varying

129-21c

[PAGE 37]
the intcnaity and duration of the stimuli, they can-be presented both below and above the subject's threshold of awareness.

A nwaber of different reactions by the subject to critical and neutral stimuli will bo recorded, Resting muscle action potential voltages from the frontalis muscles will be amplified by two cascaded, low-level, differential A.C. preamplifiers. This signal is then rectified and integrated by a constant-voltage integrator which is sampled by the sampling switch and reset by a signal from the A-D converter, following the completed conversion of the voltage, at regular 0.l second intervals.

A cardiotachoneter vill convert the interval between ECG R spikes to\_an analog voltage, representative of interavstole time. which will be sampled evory 0;25 seconda.

Pinger pulse anplitude will be derived:froa a plezoelectric transducer, amplified by a differential A,C, amplifier. held'at its maximum during the interpulse period by a peak follower, sampled at intervals of 0.25seconde, and reset by asignal from the negative phase of the rCG R spike which precedes the next pulse,

Changés in chest circunference will activate a singleturn, linear. preciaion potentiometer, which as part of a bridge circuit will provide a rough index of respiratory excursions.  This measure will be correlated with tidal and minute volume.. The amplified D.C. voltage will be sampled every 0.l second to provide a full descriptlon of the respiration cycles.

With the subiect in the feedback loop of an amplifier and a constant l00 uamperes across him, akin resistance changes of:one part in 1,G00 will be picked up by\_a ôifferential D.C. amplifier. and sampled at O.l second intervals. Non-doterminable measuremenc errors, due to. the polarization of the eleotrodes.will-be eliminated by reversing the polarity of the constant current supply every 0.5 second,

Skin teuperaturo will be mcasured with a-theristor, forning part of a D.C. bridge. Thia slowly: changing signal ie sampled every 0.25\_second.

[PAGE 38]
Changea in body-weight\_shift will\_be\_picked up by a pressure transcucer, amplified, rectified, integrated and reset at 0.25 second intervals.

Reaction time will be recoreed to the neareat millisecond by a chronometer with four binary-coded decinal decaces.This information will be traneferred directly to the tape without going through the A-D.converter.

The other analog channels will be converted into digital information and recorded on digital magnetic tape for analyais by digital couputer. The physiologic reactions associated with each stimulus constitute a\_block\_of\_about\_2,000 thirty-six bit words, which will be read into the computer one block at a time. The computer will unpack these data by sorting the prescimulug and poatimulus reactions for each phygiologic variable. Required transformatlons of Gcores will be made. It will then compute noxmalized pre-postimulus differences for each channel, taking the regresaion of che postimulus reactions on the prestimuluo responses into account. These differences fora the basis for a statistical analysis of any particular experiment. The advantages of such analysis will probably be reflected in saving of time, increased accuracy greator flexibility, and more detailed examination of a wicer range of physiologio xesponse variables and experimental conditions.

Background Hiatory

The proposed research ig a cont of work done under contract d Detailed plana forthe design and conatruction of the cquipment required to carry out this study have been made. Much thought haa gone into deviaing the best method for recording and analyzing the data to bo collected. An experiment is now underway to atudy the reaponse of subjects with inherently different perceptual orientations, under several experimentally imposed pbyoiologic conditions, to\_critical\_and neutral words of the type uaeful to the proposed study. The experlence derived from this experiment is directly\_applicable to and provides the foundation for the proposdd continuation,

3

129-21E

[PAGE 39]
Statement of Work

1. General

This project will seek to identify symbolā of special significance to human sources by recording and analyzing a variety of involuntary responses of the sources. In order to have accurate results on each source available in the shortest possible time, coaputer processing will be attempted for data reduction and analysis.It is expected that this analyeis will provide a basis for the differential weighting of the various response channels, which will maximize the differentiation between critical and neutral stimuli,

2. Specific

a. Involuntary\_reeponses

The source reactions which will be studled-arer

Muscle action potential voltage
Intersystole time
Finger pulse amplitude
Respiration cycle duration and amplitude
Skin resistance
Skin temperature
Body-weight shifts
Reaction time

b. Recording of responses

A continuous\_sampling of responses will be recorded imediately and directly on digital magnetic\_tape in a fonat suitable for digital computer processing.To permit-the uninterrupted recording of an expeximental session on a-single-reel of tape, it is Cesirable to reduce\_the\_sampling rate through analog editing of the several data channels prior to the analog to digital conversion-of-the information. The source's reactions will be monitored on an oscillograph while they are being recorded on tapo.

c. Data conversion

Converaion of the data into digital forn will be accomplished by electronic.cquipment consisting of a sampling switch, an analog to digital converter, a

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format control, a tape control, digital write electronics, and a digital tape recorder.

d. Data analysis

A-digital computer program will be\_written to accomplish the statistical analyeis of the experimental runs.

e. Nature of stimuli

Syabols\_matched in all rcspects:except their personal significance to the subject will be employed. Theintensity and duration of the atimuli will cover a range well bolow and above the subject's threshold of awareness. using tho ascending method of linits. The:inherent personal significance of the symbols will be ascertained. or. quch significanceiwill be inculcated experimentally.

f. Experimental conditions

Conditions of requiring a verbal, motoric, or no response from the subjcct will be:investigated.The freedom which the subject exercises over his voluntary responses, and the effect on producing response conflict are also of interest. Feedback of the success of tho experimenter's discrimination: to the subject deserves careful study. In addition; the context of the:experimental setting and the subject's involvement in it are vexy important.

g. Subject variablos

: Autonomically stabile subjecte are likely to react-very differently than autonomically labile subjects. Aloo, alert, perceptually.senaitive\_subjects-can be expected to bchave rather\_differently than-repressive, insensitive subjects. Thero may be further age, sex, background and experience differences, The' physiologic state of the organism to the.extent to which.it.influences Crs activity is another factor to beconsidered.

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3

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b. Discriminative potency

The value of the several physiologic variablea aa diacriminators between critical and neutral atimuli undervarious experimental conditions will be assessed, witb a view toward attaching approprlate-beta-weighte to each variable. The cross-validation of these multiple correlations is probably beyond the scope of the present contract.

Equirment

Equipment on hand at the present time consists of a sixchannel oscillooraph with drive amplifiers, an;analog to digital converter (Epsco Datrac), a cardiotachoneter, and a number of electrodes, amplifiers, integrators and power supplies for the various analog data channels.

Equipment to be purchased includes a tape. transport with digital write electronics, component parts for: the analog to digital conversion system, a shielded enclosure, and some additional transducers, amplifiers and integrators for other analog channels.

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Other Information

The organization is able to finance contracts in the amount of \$50,000.

The organization is not prepared to participate in this project.

This rescarch is unclassified.

A proposal has not been submitted to any cther agency for support.

The bidder representst (a) that he bas not employed or retained any company or person (other than a full-time bona fide employee working solely for the bidder) to solicit\_or secure this contract and (b) that he has not paid or agrced to pay to any: company or person (other than a full-time bona fide employee workingsolely for the bidder) any fee,\_conmission, percentage or brokerage fee, contingent upon or reeulting from the award of thia contracti and agrees to furnish information relating thereto as requeated by the contxacting officer.

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129.215

References

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10

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112-221

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KEMORADUM PORI COMPTROLIER

ATTERTION :—Finance Division

EMRA,Sbrojet 129

Under the suthority grented in the cemoranhua dated 13 Apr11 1953 frca the DCI to the D0/A, and the extensioa of this autherity in subeequent meoorarda, Subproject l29 hes beea approved ani \$20,000 af the over-all HOJLTRA projeet fuods hes been obligatod to cover the subproject's expenses. this obligatioa of funds ahould be charced to Allotment 1125-1009-1902.

APPROVED FOR ORLIOATTOH OF PUNDS:

Raseorch Director

Distributioni Orig a 2 - Addreacce

1-TSD/00
1-TSD/FASS

>2TSD/RB

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24 Oatober 1960

[PAGE 49]
129.23

19 October 1960 TSD/R3

ate Rocd Date Fvd 1900 19021 192 19 0ct 1901

204 20021

2020

-Meeting 25 0ct 1400 enarka

responsible officer.

[PAGE 50]
SUBJECT: Reaearch Meeting on tbe

proposal on Computer Analysis of Biolectric Reeponae Patteran vas considered at a meeting attended by had previoualy considered and approved it. was away on a training mission.

2 2.The proposal was approved by the group after some discuseion on the tendency for research whose data was to be feed into a computer to be faahioned.. It was agreed that this proposal would have considerable pertinence and promise.

3. It was explained in the course of discussion that and his assietant will move from after the nominal approval of our grant by

SG:1

129-24

21\_October 1960

MEMORANDUM FOR THE RECORD