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AlD-52'Is l-Acetyi lyiergle ecid dlethylamide. Cuoparlaca of thts drug with L5o vas vadertakea in order tv get sme Infcrnatica eb-ut strueture-aetivlty reiaticoshlps ln this serles of psychotmimetlcs.

HETHCOS

Sutjeeta. were Il Negre male former morphine addieta, all of whm had baen abstlasnt fras splates for ot lgast slx months prier to these cxperimenta. All vere la guod physlcat health and ncne had erlitence af say major fuactlonel psychoses. All ware experlenced with LSD.

Ganeral Conditlcas. Subjects sere cbservad in a special experlmeatal ward which they enlered on the alght bof.re the tcst. All wzre foailisr =lth the anyip-nnent and prccsdures. Patlents vers not sware vhat drugs were belag given, althcugh they exoocted the drugs te bave Lsb-like effsets. Cbservera, alsv,. were aot awere of the llentity cí the drugs glven ca aay parlicular lay.

Druns and Duazses Six patleats rrcclvad In raatualzed order a slacebog LSD, I segn./kg-i and AlD, I mega./kgr Feur patlants reeetved.la randealzed order a olactb.g Li, l.5 megs./g.; and AtD, l.5 mcgs./kg. Druçs esre edmlaistered oraliy at 0 a.m. when patlents were fostiag.

A370

CCMPARISUN LF.ALO-52 AND LSD-25

C106

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Cbservatl ns. Cbaervattcns ccnsisted of threahold for kaaajerk, slze of unils, systollc biccd regsure, respcare tu modificaticn of Abrameen-larvik questicnnairs, and assestmont of ellglcal grade. These measuremants vere made at hcurly iatervals, two hours befcre, aad alght hours after Ingestlen .f the drugs. nata on kaeelert, pupillary slze, and biocd pressure eere plottad ca grsph paper agalost time. Averagt of the two pre-dryg determinatlons was usad as a besalino and the arge was measured with a planimeter,ccnyerting elt dete ta e tingle figura. The resucnse t. questlonnalre wos avalvated by counting all questlcns scared posltivety after adaialstraticn of the drug, elimlnating any that were aiso scorad positively befure drug. Cllaleat grodes ware assssset sea-rdisg ro sysfes prevlously deserlbed.

Results are shoun la the. table. It Is apparent that AlD Is an actlve drug which iaduces chaages. slnllar to those Induced by LSD. Flgures also shos It tv be at leest as potant at l5D. The fact that the srades were higher for AlD at the lmmogo. lavel and much higher in lhe t.S-magn. levet suogest thet ALD nay be sonawhat aore poteat than tSo. in order fo esfabllah thls polat dsfiaiftveiy, dozr-efiect .curyes would heve to be rua, whlch hordly seems wcrthwhiie at this flas.

A-369

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Mentel phenomend cbserved elter AlD were Identical with those seen diter LsD and ccuststed of anxlety. ha lle sensatisnt, ecnfuslcn, cleer sens-rium, depersonotlzatica, dereellzation, hallucinatlons chiefly visual ia character, etc., etc.

Cuactuslcn. Al0-3? is en active psychstaioetie drug which ls at ledst es potent es LsD-25.