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In the absence of Il. am acknowledging with great Intereat and appraciation receipt of your lettar and enclosures of 19 June 1953, roference DRBs. 735-1-172 (DSI). and DRBS 2-61-301-1 (DSI).

In this acknowledgment we desire to point out in a preliuinary
woy that initial efforta either have been gade, or are under consid
eration in this country along the following lineg: 小

l... Collection\_of ergot and the,preparation of LSl as well as of otier derivativee of lysergic acid for continued teating of volunteersand aninala 23 421112

2. Screening of other potantial cerebral agents by use of apecial testa nrd gethoda, including the use of eucephalographs

3. Survey of fungi and especially muushrouas, producing potent cerobral agents; e.g. Clitocybe subilludens, csrtain rusts, used to allay fear in Satellits countrias posaibly China

4.Survey of ferns,"as yet unidentified," produaing through their spores, mental diaturbances and even death (in animala).

5. Survey of Russian and other literature dealing with fumgi used in nedicine, in ceremonies and aa intoxicarts, narcotics or otherwise, excepting fcod

6. Survey and development of poasible antidotes and other preventive measurss against offects of cerebral agents

7. lip-to-date extensive bibliographiss on

a. Lysergic acid und derivatives b. Cther agents of payohochemical intereat c. Anoxia and compounds causing mental dioorders in man

In reaponse to your queation concerning anybody doing work in

A/B, 1, 2012

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the United States similar to jours, inquiry is nw being made to obtain further iaforaatlon regariing tuch work wader way or planned.

A cooperntive imdertaking between our two countriea vay be profitable such as is now in progress in the study of Soviot research on cholinesterase. lf you consider such collaboratiun desirable, we vill be pleaeed to have your comsents and suggestions for collaboration in a program of study.

Cordially yours,

Acting Assistant pirector