[PAGE 3]
MEMORANDUM FORI Chef, FInance Divialon

:-TSD/Budget Officer

SUBJECT

: MKULTRA, Subproject 51-B, Iavoico No. 12, Allooment 2125-1390-3902

L Lvolco No. 12 in the amomt o1 \$10, 712. 00 covoring the abovo éubjproject is atteched. However duo to a refuad ofG535. 57 from MOULTRA Sobproject No. 44 (aa per attacbment) payraont should be made as followe:

Caabiera check in the amount of \$9, 764. 43 drawn ca a E bank

Caebler's check in the arocunt of \$4l2. 00 drawa ca a abaak

Both cbecss phould bo mado payabla to thol B

2. The chocks should bo forwarded to Chicf, TSD/Research Branch, througà TSD/Badgot Oiäcer, no later than 26 July 1961,

B. This is a fnal Lavoico. Howovor, since it ia anticipated that additomal fande will bo obligated for this project, the fles sheald not be closed.

T3D/Research Braach

Attachmanter Invoice & Certlfications

Distributioo:

Orig u 2- Addresoce

1- TSD/FASS

1 Project 44 file

2 - TSD/RB

A

14 July 1961

441-3

[PAGE 4]
243, 51-B

51-B

[PAGE 5]
CERTIFICATION

(3) A la boreby certined that ander Subproject 44 at the close of bY 1960 a balsnce of \$535, 57 ropregenting wused funds remained. Therefore It is requested that \$535.57'of Invoice No. 12 bo credited to Subproject No. 51-B as a relara of unused funds FY 8-2502-10-001, MOR 336.

[PAGE 6]
I em-enclosing herewith an original.and one copy of the final report of expenditures for the period of Apri1 1, 1955, through March 31, 1959, covering the grant-in-aid=to-Dr. B

Algo enclosed please find a University Check No. 89104, 1n the-amount of \$535.57 which covers the unexpended balance-remaining in this account.

Enclosures

[PAGE 7]
Receipts:

Checks received during -l955
Checks receivedduring 1956
Checks received-during 1957
Checks received-during 1958
8.108.00
16,216.00
16.216.00
8,108.00

Expenditures:

\$24,501:72 Salaries and\_Wages 9.616.37 Consumable Supplies 2.484.85 Equipment 1.055.18 Travel 1,293.72 University Retirement 351.59 Workmen's Compensation 8,808.00 Indirect Cost

Balance ax of March\_31, 1959

\$48,112.43
\$535.57

APPROVED:

T

44-7

\*Final Report

[PAGE 8]
MEMORANDUM FOR:. THE PECCRD

Action on MKULTRA Audit Exceptions-TSS/CD

SP#44

has been contected this date and an additional Dr requast made for submission of an accounting of furds since 3/31/53. We have been assured that action is being taken to conply with the request.

Chief TSS/Chemicel Division

44-8

27 Jaruary 1960

[PAGE 9]
I am enclosing herewith an original and cne copy of a financial statement for the perlod April 1, 1955, through March 31, 1958. covering the grant-in-ald from your organization to Dr. C

[PAGE 10]
Recelpts: Checks received during 1955 \$8.108;00 Checks received during 1956 16,216.00 Checks recelved\_during 1957 16,216.00 \$40,540.00

Balance as of March 31;-1958

APPROVED:

have examined and aporoved the suboitted expenditures.

\*Interim report

TSS/Chemical Divisfon

44-10

[PAGE 11]
RECBIFT

I hereby acknowledge receipt of the following two checks:

Orfictal Check Ho. 209-330h05, dravn on of E dated Apri1 30, 1958, in the axount of \$16,216.00, payable to the B

Treasurer's Check No. FE 12t18, drawn on Company E E of , datod Apr11 30, 1958, in the enouna. 648.64 payable to the B

44-11

[PAGE 12]
44-12

[PAGE 13]
MEKRANOM POR: CHTKF, PINANCE DIVISICN

i mes/Budget Ofricer

SUBJECT NLIA, tproject k, Invaice f5, A110tont 8-2502-10-001

1. Iavoice No. 5 for the above subproject ie attached. Payoant ahould to nede as follover ■

Casaier's cteck in the aocunt of \$16,216.00, árava on a bank,F

Casbier's chock in the amount af th0.Ch, drava oo bank.E

Both checks should be made payable to the B

2. Please forvard the checka to Chief, Tss/Chenical Divisioo, through Tss/Budget orticer, no later than Xonday 12  1958.

3.  Tis invoice represente the total amaunt currently suthorized under Subproject 56. Rowever, since it is antictpated that edditiocal funds vill be obligatod far this project, the files ahould not be closed.

Chiet TS8/Cheaical Divisioa

Attachmitet Iovoice and Certificatione

Diatributiont Orig & 2 = Addresose TSS/FASB 2.TSS/CD

APR ORIGATE 10-01 CHALS 1

21 Apr11 1958

X

44-13

[PAGE 14]
INVOICE

\$16,864.64

CERTIFICATIONS

(1) It is beroby certiried that this is Invoice No.5 applying to Subproject 44 of WLina, that performence is satisfectory, that services are being accoopliahed in accordance vith mutual egreements, that a detailed sgenda of the payments end recoipts is on file in Tss/cD, that this bill is just and correct and that paypent thereor bas not yet been oade.

Chief, TSS/Chemical Division

Dee

(2) It is bereby certified that this invoice epplies to Subproject 44 of HuLTRA which vee duly approved, and that the project is being carried cut in accordence with the peaoraodu dated 13 April 1953 frca the DCI to the DO/A, ani the extension of this authority in subsequent peporanda.

Date:

[PAGE 15]
MOORAOON TOB COMPTRCLIER

ArSgTIOa Finacce Diviaicn

SUNEProjct VLA, Sbpjoct 4h

Uoier the authority granted in the Monorandas dated

13 April 1953 fres tha DCI to the D0/a, end the exteneicn of this

oxthority in subeequent mesoranla, Subproject hh bas booa approved,

od 16,80.6 of the over-ell project UL fumds bag beeh

chligated to cover tbe eubprojeot's exponnes anl should be charged

to A110t00t 8-2502-10-001。

APPROVED FOR ORLIGATION OF PUNSI

Acting Chiar Tes/Cheatcal Diviaioa

Cind tad by A

336 8.3502-10-001

Research Director

Dietributiont Orig & 2 - Addreesco

1 -TSS/0

-TSS/PASB

1--TSS/SRB

2 - TSS/CD

SEeRE

B 0 15

[PAGE 16]
12 Aaak 1957

MEOORARDUM TO COPEROLLER

ARTXArIONt Finance Divieion

BProjot L, Dbpoject 44

Unler the authority craoted in the Morandus dated

13 Apr12 1953 froa he D0I to the D0/A, soi the exteco1oa of taie

suthority in enbeequent mmoroola, Subprajeot 44 bas been approvol,

and 16,8. a the ow-all projst  fds boe been

caligatel to cover tha subproject'a expepsos aod should be charzel

to A110tzont 8-2502-10-001.

APPACEED FOR ONLIGATICS CF FUNDOI

Reacoich Director

Dete

Diatriburtiont Orig & 2 - Adireeoca

1 - TS3/∞

1-TSS/PASB

1 - TS/B

2-1Ss/cD

SEORET

[PAGE 17]
SUBJECT: Project MKULTRA, Subproject h4

1. The purpose of thia subproject is to continue the research B being carried out by Professor of the University of This vork is aimed at the depign of laboratory methods for screening psychochemical materials. These methods can then be the basis for procedures to be carried out in other-Tss/CD-laboratories on a classified basis.

2. During the past year the goal of this project was the perfection and teating of two apeciric assay methods related to the above problem. This goal wes adequately reached and in addition a considerable amount of incidental information was accumulated which bas alded to the general knovledge of materials which affect the ceptral nervous. system.

The funds for this project will be transferred using the las a cut-out in the usual MET

4. The total cost of this program for a period of one yeer beginning 1 July 1957 wi11 be \$16,216.00. To this must be added a four percent (4%) service charge to the or its services. B The total cost-for the-above period will thus not exceed \$16,864.64.

5. has requested the University to subait to B them a sumery accounting or monies received from the-Fund.Also, they requeated the return of any unexpended-funds received under a grant-from the Fund at the end of the program.

6. Title to any- permanent equipment purchased by funds granted the shall be retained by the University in lieu University of higher overhead rates. T

7. It is agreed-that documentation and accounting for travel expenses which are reimoursable by the-University shall conform to the accepted practices of that Institution.

Attachmente: Proposel Budget

Actirg Chief TSS/Chemical Division

APPROVED FOR OBLIGATION OF-FUNDS: A Fesearch Director

Date sleng 16- 19-Z awncraded to: CONFDOTIAL by authortof:ao7ro cato: Leto 19e?

Diatribution: Orig. oaly.

23 IMPDET; CL BY 1SN175

[PAGE 18]
Thank yoa for yotür kind reninder, over tbe tolephone, last week in asking me for a request in the renewal of our for another year grant beginning Jaly 1, 1957.

A progrèss report of the project during the academic year 1956-1957 is appended.

The genarsl plan of our research for the coming year consists in further perfection of mothodology and in the axanination by our new methods of a large mumber of important agants with potential effects n behavior. This research is not supported by other sources.

Our request/is again for the same sum of \$16,216.00. The proposed bodget plan is as follows:

June 11, 1957

WARNING NOTICESENSITIVONTELLIGENCEHLOLVEDSOURCES AND MET

[PAGE 19]
Worken's Componsation 150

Eployer's Contribution to-813 Retirement\_Systen

University Overbead or 2,116 Indirect Costs 15%

Total

\$16,216.00

I shsll be greatful if your Foundation will support our project for another year.

Sincorely yours,

HEAD OF THE DSPUTENT

BODGST APPROVgD BY

SOURCES AND METHOOS INVOLVED

60

[PAGE 20]
I hereby acknowledge receipt of the following two checks

E
Cashier's check No. DM 37787. drawn on
t the amount of si0 st0.67, payablotoSeptember 4. 1956 B B
Cashier's chech No. A105603, drawn on the F dated September 1
1956, in the amount of \$432. 43, payable to the B B

[PAGE 21]
MEMOBANDUM FOR: CHIEY. FINANCB DIVISICH

TSS/Budget Olficev.

MKULTRA Sabproject 44
Iavoice Nc. 4, Allotment 6-2502-10-001

l.  tavolco No. 4 for the above subproject is atiached. Payment should be made as follows:

Casbier's check in tha amount of \$l0, 8l10.67, draw on a E bank, Cashiera check la the anount of \$432. 43, drawn on a 衫 bank.

Both chocks should be made payable to the

2. Please forward the checks to Chtef, TSS/Chemlcal Divislon throogh TSS/Budget Offlcer by Monday, 1 October l95s.

3. This is a (inal tūvolce. A totat of 3l0, 864.64 was obligated undar this aubproiect during FY 56. Hcwever since It is antlclpated that additlonal funds will be obligated for thts project, the flles should not be closed.

SIDNEY GOTTLIEB Chtet: TSS/Chemlcal DtvIslon

Attachments: Involce & Certifications

T CERTFY THAT PUNES AN AVATAGC 111955
CGON 3582
CH106250210-001

\- TSS/FASB

CHECKOJ77E AMGUNT OF SOR RECEIVEC18P

CHECKA0S693 THE AMOUNT OF SLE 1956

10 September 1956

[PAGE 22]
CERTIFICATIONS

(1) It ts hereby certifled that thts Is Involce No. 4 applying to Subproject 44 of MKULTRA, that performance is satisfactory. that the services are being accomplished in accordance with mutual agreements, that a detalled agenda of the payments and receipls is on flle In TSS/CD, that this blll is just and correct and that payment thereof bas not yet been made.

Chtef, TSS/Chemical Diviston

Date:

(2) It is bereby certifled that thts tavoice applies\_to Subproject 44 of MKULTRA wbleh was duly approved, and that the project ls being carrled out in ccordanco with the memorandom dated 13 April 1953 from the DCI to the DD/A, and the extenslon of this authority in subaequent memoranda. :1

Dato:

Research Director

[PAGE 23]
Receipt is hereby acknowledged of the following two checks:

Cashier's Check No. DM 36875, dated July 1l, 1956, drawn on the in the amount of E \$5, 405.33, payable to the

Official Check No, G 9586, dated July 12, 1956, drawn on the in the amount of \$216.21, payable to the Inc.

Date 1 山

Receipt is hereby acknowledged of the following two checks:.

月 Cashier's Check No. DM 36875. dated July 1l, 1956, drawn on the . in the amount of

Official Check No. G 9586, dated July 12, 1956, drawn on the E in the àmount of.\$216. 21, payable to the B

[PAGE 24]
MKULTRA Subproject 44
Involce No. 3, Allotment 8-2502-10-001

1. Invoice No. or e aoovs suorojot  au. ment should be made as followst Cashler's check in tho amouat of \$5. 405.33, drawn on a fbank. Casbler's check to the amount of \$216.2l, dravn on a bank

Both checks should be made payable to the Other involces wlll follow later.

2. Please forward tne checks to Chlet, TSS/Chemical Division through TS5/Budget Officer by Wednesday, 18 July 1958.

Acting Chiel TSS/Cbemlcal Division

Attacbments:
Iavolce & Certlfications
(Orig &1)

Distributloal Orlg & 2- Addressee 1-comptroller CERTFY TT FDIDS ARE AVAILABLE JuL CN82 195

1FASB/TSS CHECK#G 9SAN THE AMSUNT OF S2/6
2- TSS/CD RECEIVED.16

EEEHEOR#NAN THE AMOUNT OF SS

[PAGE 25]
CERTIFICATIÓNS

(l) It ts hereby certified that this is Involce No. 3 applylng to Subproject 44 of MKULTRA, that performance is satisfactory, that the services are being accomplished in accordance with mutual agree ments, that a detailed agenda of the payments and recelpts is on flle in TSS/CD, that this bill is just and correct and that payment thereof has not yet been made.

Acting Chiel, TSS/Chemical Division

Date:

(2) It is hereby certified that this invdce applies to Subproject 44 of MKULTRA which was duly approved, and that the project is being carrted out in accordance with the memorandum dated 13 Apr!l 1953 from the DCI to the DD/A, and the extenslon of this authority in subsequent memoranda.

Research Director

[PAGE 27]
Uader the aatborlty granted (a the memorandum dated 13 April 1953, from the DCI to the DD/A and the extenslon of this aethorlty la subeequont memaoranda, Subproject 44 was. prevlously approved. Uader the same sulhorlty an additional sum of \$16, 804.64 bas beea avthorlaed to cover tho subproject's expenses (ibereby bringlag to a total of \$25, 730.88 (ands obllgated during PY S6). to be ehsrged to Allotment 8-2502-10-001.

Acttog Cblet TSS/Chemoical Diviston

APPROVED FOR OSLIGATION OF FUNDS:

CRALALE RGAT 2581 GHARGE TO 6.2503-10.01

Distributioni Orig& 2 - Addressee

1-TSS/0C11-TSS/FASB1- TSS/SRB2//CD2

TSS/CD 25 Junp9956) A DWIN

[PAGE 28]
l. The purpose of this project is to orovide funds for the continued partial support of Professor the work on C B

The solution to the problem of assay methods of this type is of paramount importance to a considerable area of the work going on in TSS/CD. The lack of adequatei ethods of this kind has proved to be a bottleneck in the synthetic cherical field as well as in that of the extraction of botanical sources across the board.

2. In addition to being eminently qualified to pursue this study, Professorspecialized knowledge in the field of curarizing agents and his up-to-date knowledge of laboratories and personnel has been of great value to the Agency in the past.

3. The physical facilities made available by this project are as follows:

1. The complete pharmacology testing laboratories, of the B

2. A ward with subjects for human testing at B

3. The use of equipment and consultations with personnel in otber medical departments at the

The funds for this project will be transferred using the as a cut-out in the B usual manner,

5.The total cost of this program for a period of one year beginning 1 July 1956 will be \$16, 216.00. To this must be added a four percent (4%) service charge to thee for its B

Dovngraded to: CelinL by cthorlty oiaaera Cate: J0:1977 E2-1MPDET; CL DOCTA2S

cat93Jo 1977

DRAFT/HWB/aca

25 June 1956

44-25

MEMORANDUM FOR: THERECORD

SUBJECT:

Project MKULTRA, Subproject 44

[PAGE 29]
services. The total cost for the above period will thus not exceed \$16,864.64.

6. The as requested the University to submit to them a summary accounting of monies received from the Fund. Also, they requested the return of any unexpended funds re ceived under a grant from the Fund at the end of the program.

. 7. Title to any permanent equipment purchased by funds granted the University School of shall be retained by the University in lieu of higher overhead rates.

8. It is agreed that documentation and accounting for travel expenses which are reimbursable by the University shall conform to the accepted practices of that Institution.

9. It is agreed that technical reports reflecting the progress of the research program should be submitted at mutually acceptable intervals.

10.  is cleared TOP SECRET by the Agency and is aware of the sensitive nature of-the work.

Acting Chief TSS/Chemical Division

Attachments: Proposal Budget—

APPROVED FOROBLIGATION OF FUNDS:

Date: June 26, 1AN6.

Distribution: Original only

44-25

[PAGE 30]
The results of the first year's work in this research program indicate that it is quite possible to design methods whereby chemical compounds having certain types of pysctiomimetic effects can be detected without recourse to human testing except as the final confirmation, In order to do this it is, of course, necessary to determine first in model compounds of known potency those measurable peripheral effects which are related to the desired psychomimetic effect most directly. In other words, a given chemical grouping in a molecule may be responsible for certain peripheral reactions due to its presence in the peripheral circulation and yet be responsible also for a vastly different effect in the central nervous system due to the different metabolic processes responsible for the characteristic activity of the different types of tissue.Very few chemical compounds are known which produce only one kind of effect in the animal body. Compounds which produce the desired psychomimetic effect are no exception to this and in general seem to have a relatively wide spectrum of other effects on the animal. Since we are not at present able to measure psychologicat changes in animals with any degree of certainty we are limited to méasurement of changes in those aspects of central nervous system activity which are reflected in the periphery,or to purely peripheral effects of the cherical compound.

Two quite different families of problems emerge from a consideration of these facts. First of all, the detailed pharmacology of a number of materials having the desired activity has to be assembled, either from the literature or by determination. Once this information is at hand. an analysis of the relationships between the various measurable effects coupled with the knowledge of how such effects are produced can lead to hypotheses about the relationship between various peripheral and central nervous system effects. These hypotheses can then be tested by experiment to indicate which measurable peripheral effect or group of effects is most likely to be an accurate measure of the psychomimetic effect. We áre also faced here by the fact that we must determine whether a given compound has access to the body area of interest in addition to possessing the proper configuration to produce a psychomimeti effect once it gets there.-This latter question is brought about by the existence of the blood-brain barrier which denies access\_tothe\_ central nervous system to many peripherally açtive compounds and possibly on the basis of chemical groups quite unrelated to those responsible for the compound's activity. Therefore, in order to make a useful screening technique we must not only measure activity but also the\_ability to cross this barrier. with ease.

PROPOSAL

414-25

WARNING NOTIGESENSITIVE INYELLIGENCE

[PAGE 31]
The work so far has indicated that chemical groups which alter the action of the body tem perature regulating center in a specific way seem also to possess the desired psychomimetic activity and such a test appears to have certain practical advantages from a laboratory point of view. Several other workable tests invoiving small animals such as the measurement of total body activity may also be useful indices of psychomimetic activity. 1

In the course of the work this year we have tested a number of compounds of a completely different chemical nature from the known psychomimetic agents. The animal tests indicate that these compounds may be psychomimetic in man. During the coming year we propose to complete the work on the screening techniques so far developed and put them on a basis that will make them useful as routine laboratory test procedures. Also, we shall continue work with the new agents, carrying them to human test to verify their psychomimetic activity. In addition, we will continue to test other series of compounds available to us as candidate agents in this area and those compounds submitted by the ffor evaluation. B

44.25

WARNING NOTIGE SENSTTIVE INTELLIGENCE CES AND METHODSINVOLVED

[PAGE 32]
BUDGET

AMOUNT TOTAL

WARNING NOTICESENSITIVE TTELLIGENCE

SOURCES AND MFTHODS TINOLVED

[PAGE 33]
I hareby scknevlodge receipt of the Zolleving checkat

天 in the amount of \$33,667.00, Ofcioiel Check Mo209528 dated 22 Sept 55,

Cushier1 Check f06122 dated 22 Sopt 55, EEin the ahomnt of 810,810.67,

Casbior's Chock fU4123, dated 22 Sep 55,

Dator fetinte. 28 1955s

[PAGE 34]
KEMBANDUA PR: GEOEP, FLAECE DIVISION

A Suboroject 44. Loroioe 2
A110taat5-2502-10-001&6-2502-10-001

1. Invoice f2 is attached ccrering the abore zubpreject. This is a final invoics. It is requestod that payxent be made ae fellowg:

Ws cashier's cheok 1a the amomnt of \$10,810.67s and E e ascond ahect for 32.63, both dreva on bok and parablo to tho B

2. Both cbeoka shoald bo forveriel to Chief, Tss/Co, throgh T8s/Budget Crficer no later than 30 Sopteaber 1955.

3. Those tuo invoices covering thia subprojeot agerogate \$16,864.64 and mako upe of Ue FY 55 funds cbligatod woder this pubproject plns tho F1 56 funde cbligated to date. Sincs it ie apected that additional obligations of Cuds uder this mabproject involving cvrreat Ficcal Year funds will ba medo, the files cn this projeat should not be closed.

SIDIRY GOTTLICH Chief rss/Cheaical Division

Attachsonte! Invoice & Certificationa

ICERTIFY THAT FUNDS ARE AVAIAELS:

Distributioni Orig k 2 - Addrosoee 1- Captroller 1-TSS/FASB 2- TSS/CD

5-3502-10.001 \$222 1237
6-2502.10:0018864

135/c0 (13 8opteaber 1955) F CHECKT HRLIN THE AMOUNT. OF SADO6 RECEIVES. 271953

[PAGE 35]
(1) It ia hereby certified that this is Invoice #2 applying to Subproject 44 of HEULIRA, that performance is satisfactory, that the sarvices are being acooupliahed in aocordance with mutual agreenenta, that a detailed agends of the paymonts and receipta is on file in TSs/CD, that this bill is just and correct\_and that payment thereof hes not yet been mads.

(2) It is bereby certified that thia invoice applies to Sub. project 44 under MULTRA which was duly approved and that the projeot is being carried out in accordance with the memorandum dated 13 April i953 froa the DCt to the DO/A, and the extonsion of this authority in subsoquent momoranda.

Dator

Research Director

[PAGE 36]
Uodor tho antbority graated in thd meorandua dated

13 April 1953 ro the DCt to the 10/A, and the extenaion of this anthority in subesquant zocorands, Subproject 44 ws prwvloaaly approved. Under the sana anthority en additioel m of \$3,864.64 hee been authorired to cover the ealprojeot'a arpanpss, (thoreby bringing to a total of \$8,864.64 funds obligatod during 78 56) to bo, chargod to A11ot0t 6-2502-10-001.

SIDHEY GOTTLIEO Chlet TSS/Cheuicsl Diviaion

Diatribotiont Orig a 2 - Addresvce

I CERTIFY THAT FUNDS ARE AVAILASLE CLUGATION RESCE2 CHARGE TO ALLOIMENI NO. 11A9 6-0532.10.001 AUTHORIZING CHICE

1-TSS/OC1-TSS/FASB1 - TSS/SRB2-TSS/CD

SEORKE

[PAGE 37]
1 Addendum to Subproject 44

1. The purpose of this addendum is to set forth the mutual administrative responsibilities of the contractor end sponsor,

C2. The above subproject represents the research proeram of B Dr. financed by MKULiRA, covering the period of 25 April 1955 through 31 March 1956.

3.. The mphas requested the University to submit to them-a-summary-accounting of monies received from the Fund. Also, they requested the return of any unexpended funds received under a grant from the Fund.

4. Title to any permanent equipment purchased by funds granted the University, School of shall be-retained byB the University in-lieu of higher overhead rates.

5. It was mutually agreed that documentation and accounting for travel expenses which are reimbursable by the University shall conform with the accepted practices of that.Institution.

6. It was agreed that technical reports reflecting the progress of the research program shall be submitted at mutually acceptable intervals.

SEBER 28 July 1955

44-29

MEMORANDUM FOR: THE RECORD

Distribution: Orig & 1 - TSS/CD

[PAGE 42]
Invaico Yo. 1 for Saboject 44 of Projoct MURA is attachal. Othar involces vill follov later. It is roqueated that payant bo mads by tuo cashiers checks, ooo in tho anount of 85.405.33, and one 1or \$216,21, payablo to tho Ti The pheche etonld be soat to Chiof, Tes/cD thraugh TSS/Baiget Octioor by Vodneaiay, 6 Aprll 1955.

SIDNY COTTLIEB Ghiel TSS/Chesical Divisioo

4 APR ENTO AUTHORIZING OFFICER

[PAGE 43]
(1) It is hareby certiried that this is Iavoice Ho. 1 applying to Subproject 44 of Projoct HKULTRA, that performance vas satisfactory, that the services vere accoaplished in accordance with zutuai agresarnts, that a detailed agenda of the paymonts and receipts are on file in TSs/CD, that this bill is just and correot and that parmunt thereof has not yet been made.

SIDNEY GOTTLIEB Chier,TSS/CD

(2) It is bereby certiried that this involce applies to Subpaojeat 4 ider Profect Haulia vhich was duly approved and that the profect is baing csrried out in accordancs vith the eorand dated 13 April 1953 froa the DCI to tho DD/A, and the extansion of this authority in subsoguent meuoranda.

[PAGE 44]
Vadee the autbority graatod in the Mamrsoda datod 13 Apai1l 1953 froa tha DCr to tho D0/A, and the extenaics of this mathority in sabsequcat zcworenda, Subproject 44 haa boen approved, and 3,000.00 of tho over-al1 project aaRA ude bae boen cbligated to cover the cabprojoct'a expenses and ahoald bo chargod to 411otaont 5 2502-10-001.

I CERTIPY THAT FUNDS ARE AVALLALE;A OBUCATION REFSRENCE NO.

[PAGE 46]
: Project MKULIRA, Subproject 44

1. The purpose of this project is to provide funds for the study of the pharmacodynamics of derivative and homologues of hydrogenated aromatic amines.

2. The attached proposal indicates the extent of the investigations that will be carried out in these facilities B available at the

3. The-funds for this project will be transferred using the as-a cut-out B in the usual manner.

4. The cost of this program for a period cf one yesr will be \$16,216.00. To-this must be added a four percent (4%) service B charge to thee for its services. The total cost for the above period w111 thus not exceed \$16,864.64.At the present time, the sum of \$8,000.00, representing \$7,680.00 to the plus \$320.00 fee to the B is being committed. The balance of the-total will be-committed at a later-date.

5. Both Dr,and Dr are cleared-TOP SECRET by the Agency and are aware of the sensitive nature\_of this work.

APPROVED FOR OBLIGATION OF FUNDS: 44

TSS/Chemical-Division

Date: 24 War 55

APPROVED:

APPROVED FOR ADDITIONAL APFROPRIATION OF \$8,864.64:0

.SUBJECT

DRAFT/A 22 March 1955

MEMORANDUM FOR: THE RECCRD

Attachment: Propoçal

Date: 10 A uquit 1955

[PAGE 47]
Enclosed is a research proposal concerned with the investigation of the-pharmacological properties of aronatio amines. The cost of the project 1s estimated at \$16,216.00 for the duration of one year.

This proposal is submitted in duplicate to you snd your board of directors. I hope that your board will pass favorably on this application.

Enclosures2

Downgrudeeto: athoyity IMFDET; CL BY 187475

WARNING NOTICE SENSITIVE INTE GENCE GOURCES AND METHICDS INVOI

[PAGE 48]
A. GENERAL STATEMENT REQUESTING CONSIDERATION OF PROPOSAL:

consider It is requested thet tho a proposal for their support of a project concerned with the investigation of the pharmacological properties of certsin aromatic amines which possess syapathoaimetic activity.

B. BRIEP REVIEW OF SCIENTIFIC BACNGROUND OF PROPOSED INVESTIGATION

It is generally considered, today, that the responses and physical adjustments of an organisn to an environmental stress consist of two phasas which occur in sequence. The first phase of rapid adjustment is conceived to be mediated through the autonoic nervous system; the second phase of adjustment to chronic stress is belisved to mediate chiefly through the pituitaryadrenal system.

Although the majority of syupathomimetic anines which have. boen studied pharmacologically have been derivatives of alkylamines, recent studies have indicated that a variety of non-aliphatic amines exist in the mamalian body and possess sigmificant physiological activity. Tro exampleß of such non-alighatio compounds may be mentioned: Adrenoxine,a metabolic product of epinephrine, and 5-hydroxytryptamine or serotonin, a sabstituted heterocyclic amine. Both adrenoxine and serotonin possess a physiological activity anelogous to that of epinephrine.

Beta-tetrabydronaphthylamine is a protctype of a series-of coapounds first ayathsized by Stern in l888 which poasess significant sympathomimetio activity, bat which are not ethanolamines. One major difference between the actions of tetrahydronaphtbylamines and those of the ethanolamines is that the actions of the forwer are not-antagonised by ergotamine, nor are they potentiated by cocaine. (Bouckaert, J. J., and Heymans, C., Areh. Int. Pharmacotyn., 35:137, 1929.)Ferhaps becanse the most obvious effects of tetrahydronaphthylamines are on body temperature,-few studies of their general pharmacological actions, and specifically their syupathomimetic aotivity,-have been mada since the classic stpdy of Jonescu in l909.

C. TECHNICAL DESCRIPTION OF THE PROPOSED WORK

1. Objectives:

It is propooed that the pharmacodynamics of a series of derivatives and homologues of beta-tetrahydronaphthylamine be studied. The pattern of studies would bo arranged tomeet the following objectives:

a) The evaluation of the pharmacological effects of a series of such compounda. Particular attention would be paid to general toxicity (potency) and the effects of the compounds oni the cardiovascular systea in perticular, and on smooth muscle, in general.

b) An attempt to rəlate the chenical structures of such compounds to their biological effacts and their potencies in producing the effects. The chemical stracture of the compounds under study would also be related, if possible, to the chemical struotures of sub-
-akances with similar biologicel activity.

Department B

aty7475

WARNINO NOTICE

SENSTTIVE INTERRGENCE

[PAGE 49]
o) The potontiation and the antagonism of the effects of the compounds under study will be investigated in the light of the actions of tho same synergistists and antagonists on the biological activity of the natorally occuring ethanol amines. The biological interaction of the compounds to be atudied and tho sympathominetic ethanol amines will be investigated, as well as the ability of the derivatives of tetrahydronaphthylamine to modify the responses of the autononic nervous system to stress.

2. Methods;

The methods to be employed will include studies of toxicity of the\_compounds, their effects on the cardiovascular system in situ and the effects on smooth muscle containing organs - such as the ileu, and uterus in situ and in vitro, and such special atudles, using specialized techniques, as may seem necossary (such special atudies might include electrophysiologica techniques for the study of skin temperature changes central nervous aystem activity, activity of autonomic ganglia, ete.)

D. DESCRIPTION OF FACILITIES AVAILABLE FOR PERFORINO THE CONTEMPLATED WORK

Laboratory space and facilities for research on cardiovascular systen including heart-lung preparations; facilities for smooth muscle work in vitro and in vivo. Facilities for toxicologic research. Facilities for electrophysiologic research on the central and autonomic system,-including electrcencephalography, isolated nerve potentials, cscillography, stereotoxic instrument, etc.

E. NAVES OF PRINCIPAL INVESTIGATOR AND PROFESSIONAL ASSOCIATES

w, k.S., v.D.

6Peao.s.,v.D.

grad:CODEN ethy of1874 2m475

WARNING NOTICE SOURCEC SENSITIVE INTENESANCE

[PAGE 50]
P. ESTDMATED DURATION OF PROJECT AND YEARLY BUDGET BREAKDOWN

It is estimated that the duration of the projèct will be about one year. An estimated budget for a year of such resoarch would be:

IT

AMOUNTTOTAL

Salaries Principle Investigator (Charged to University) Graduate Student \$3600.00 Neuropharmacologist, 3 monthe at \$500 per month 1500.00 Reeearch Pharsacologist,5months at \$500/month 2500.00

\$7600.00

Bouipment and Supplies Including animals, drugs, etc.

Travel and Other Expenses

Workman's Coupensation on \$7600.00 at 1.5%

Retirexent on \$2000.00 at 7.79%

Subtotal12,870.00

Indirect Cost at 26% of Subtotal

TOTAL \$16,216.00

Participation by the
principle investigator, routine clerical help, laboratory spece and utilities (including laboratory equiprent for studies in experimental pharmacology snd neuropharmacology).

Doered to: CDE byavhority t: 82176 E2 D1DE: CL P17475

WARNING NOTCE

SOURCES AND METHODS INVOLVE

[PAGE 51]
AGREEMENT FOR COOPERATIVE INVESTIGATION ARTICLES OF AGREEMENT between the Board of Trustees of of the First Part, hereinafter called the University, and e电nd thg :y to

córporate
legai oa p mbpu pp aou  py  oh c    v e
title.) Party of the Second Part, hereinafter called the Sponsor, for a cooperative investigation described as follows:

1:13 the investigation to be carried out by. the Uoiversity in the Department(s)-of:

one:of its rescareh. agencies, under the teruis and-conditions specifed herein.

(1) This agreement is executed for the following period:

with the understanding that it may be extended. for additional periods under the same terms or such other terms as may be mutually. agreed upon; provided that the Sponsor shall request such, extension in writing not iess than thirty (30) days before this original agreement expires. The University reserves the right to decline to exteod this agreement beyond the expiration date if the seitntific or seholarly- results realized or reasonably anticipated do not in the judgmęnt of its ofcials warrant continuation of the prograu.

(2) The conduct of the investigation shall be under the full control of the University which will supervise and-: direct all experimental work and the computation and reduction of all results obtained, together with the placing of these data into form for presentation..

(3) The University will furnish the necessary space for this investigation, together with heat, light, power, and water. In addition, it will permit the use of such laboratory apparatus and experimental facilities as it may possess which are not in use for other purposes. It is agreed, however, that apparatus, equipment, and other facilities not available in the laboratories of the University, and all materials and supplies required in the investigation, shall be purchased from and charged against the funds for this investigation provided by the Sponsor.

[PAGE 52]
(9) The Sponsor agrecs to pay the Uaiversity the sum of investigation, such payments to, be according to the following schedule:

(All checks should be drawn payable to the For projects on thecampus, remittance should be sent to the Bursar, For-projects carried on in the Colleges of , reuittance should be sent to the Business Manager, FES

IT IS UNDERSTOOD AND AGREED THAT the paymenT of the above sum as stipulated is conditioned upon the conduct of the investigation by the University with due diligence so as to secure the greatest possible progress consistent with the nature of the work.

(10) This agreement is subject to the applicable constitutional aud-statutory provisions of the State o

IN WITNESS WHERSOF, the authorized officera of the respective parties have hereunto set their hands and the. seals of the parties, this. . day of ,19 (Oate) (Montb)

APPBOVED FOR THE UNIVERSITY BY:

Head of Departmrat

THE BOARD OF TRUETEES OF THE PARTY OF THE FIRST PART

Deaa or Director

Comptroller

Legal Counael

(Date)

By.

Secretary

Bursat/Business Maniager

(Date)

For the Presidenț

(Date)

By.

to cover the expenses of thi 44-39

Party of the Second Part

(45228)

[PAGE 53]
(4) All records of the investigon are to be the property of the Universityi the Spousor. The original records
shall be kept on fle by the University, but copies of all such records shall be furnished the Sponsor or his duly author
ized represeatative on request. The University shall have the éxclusive right to publish at its discretion the tsults of
the investigation in the formn of a bulletin or bulletins, or otherwise, No account of a cooperative research project or
reprints of scientific articles resulting from the investigation shall be published by the Sponsor or by any other ageney,
except upon approval of the division of the University or head of the departmént in which the work is being done. ant nan tha

Prior to such publication, no publicity shall be given to any of the results of the investigation except upon the recommcndation or with the approval of-the University and'the Sponsor, unless the scientife value, of a discovery made during the course of the investigation be such that, in the judgmeat of the University, the public interest requires prompt release or publication thereof. The publication, if any, shall contain a description of the investigation and a report of the results and ccnclusions; full credit shall be given the Sponsor and every person and agency having made a significant contribution-to the.results obtained. a sgman,cut- g.

It is agreed that under no circumstances, will the, Soonsor state or imply in any publication or. other published announceunent that the University. has tested or approved any, manufactored product, manufactured,, sold, or distributed under a specife brand, name, or trademark. It is also agreed by the Sponsor that it will not under any circumnstances use the nare of the University in any advertisement, whether with reference to the cooperative agreement or any other matter, without the prior approval of the University.

(5) .Authorized representatives of the Sponsor shall at all-times-have access to the data secured and resulta computed from the investigation, subject, however, to the restrictions named in Article 4. The University will submit such reports of progress to the Sponsor as may seem desirable. An advisory committee may be named by the parties to consist of such persons and have such duties as may be mutually agreed upon..

\- (6) It is agreed that all resuits of experitgentat work-of-this investigation, including patentable discoveries, carried on under the direction of the seientifc staff of the\_University-belong to the University and to the publie and shall be used and controlled so ss to produce the greatest bencfits to the public..

It is agreed that if patentable discoveries grow out of the investigation snd such discoveries have commercial value, the Sponsor, upon payment of the entire cost of securing a patent, shall be given free use of the patent as a non-exclusive licensce, it being agreed that other licensees shall pay.the University a royalty whieh in the opinion of the University is fair to the Sponsor and to the public.

The Sponsor shall notify the University in writing whether it will pay the çosts of 6ling an application and precuring a patent on any discoveries which may be patentable within sixty (60) days from the date when the University gives the Sponsor notice of any such discovery. In case the Sponsor-docs not wish to assurne the expense of securing a patent, the University may, in its diseretion, do so, and the Sponsor shall be given a non-exolusive license on substantially simoilar terms as other liceosees.

(7) All technical, clerical, and other personnel necessary for the effective prosecution of this investigation shall be employed by the University and paid from fuads provided by the Sponsor. Such personnel shali be employees of the University during their empioyment in this investigation and shall in all respects be subject to the ruies and regulations of the Upiversity governing staff members and emoployees.

(8) The money contributed for this investigation shall be held as a special fund and shall be so carried on the books of the University. Disbursements from this fund shall be made only for this investigation for the following purposes: (a) Compensation for personal services (b) Materials and supplies (c) Equipment (d) Communication and travel (e) Employer's contribution to University Retiremeot System for retirement, disability, and death benefts for participating employees (f) Rescrve for"liability under Workmen's Compensation Act (1½/% of item a) (g) Other costs directly attributable to the projeet (h) Partial reimbursements for indireet costs of the Uuiversity attributable ). Such payments will be approved by officers of the University in to the contract (.o of imrnčdiate or supervisory charge of the investigation.

[PAGE 54]
4/./55 562154 124310
2 9/11/55 1124310
5 shl16 5621.54 11.243.10
4 1026124310
5 8100195816,86464