[PAGE 1]
PROPOSAL

It is proposed to continue research on problems critical to a clarification of the fundameutal aspects of the stimulua-response relationship in biological'syatems. Studiee will be conducted utilizing chronic aoimal preparatione with permanent soptal electrodes. Inveetigations will ba conducted utiliring chronic eloctrode preparations coupled with selected classical types of conditioning. Studies will be conducted on the geography of the brain in selected speciea of animale to determine the locue in which stimulations will produce specific reactions.

A careful literature survey, eepecially of tbe Russian

literature,of foreign research in this area will be\_ conducted.

106

ftt

[PAGE 2]
Project: MKULTRA, Subprojoct 106

Date Initieted: Janvary 1961

Date Expires: January 1962

Funde-current year1 \$12, 000.00

Purpose: To provide consulting service snd Slavic langusge litorature review of various foreigu biological und psychologieal areas technology related to BW.

Statust The projoet is In its secoad year and is coatinuing to produce adequately.

[PAGE 3]
selaaeo Aecunt Icvoics Kucber 00 Auth2 PRNAFS

[PAGE 4]
MEMORANDUM FOR: CHIEF, FINANCEDIVISION

VIA : Tss/Budget Officor

SUBJECT : MEULTRA. Sobproject 106, Iavolee #1 Allotment 0525-1009-4902

I. Involce No, i coveriag the above-subprojoct la attached. Peymeet should be mado se follows:

Casblez'g check in the amount of \$sil. 00 payabla dee

1B drewo

Cashler'e check in the amcunt of \$2i, Olf.00 payable Aeiwn on

2. Please forward tho checks to Chief, TSS/Chemical Divlaion through TSS/Budget Ofllcer by lo February 1960.

3. Thle le a final involce. However, slaco it is anticipated that edditlonal fueds wiil be obligated for,this project, the files shoald aot be clcaed.

TSS/Chemical Division

Attachmente:

Invoice & Certiflcations

Dietribation: Orig k 2- Addrosseo

1 --TSS/FASB

2--TSS/CD

106 3

27 January 1960

[PAGE 5]
INVOICE

CERTIFICATIONS

(1) It in hereby cortified that thlo la Iovoice #l applying to Subproject l06 of MKULTRA, that porforinance la eatiofactory. that servlcea are being accompliubed in accordance with mutual agreements, that a detailed aganda of the payments and recelpte le flled la TSs/CD, that thie bill is juat and correct and that payment thereof hae not yet beea made.

Chief. TSS/Chemical Divlsioa

(2) It lo hereby cortified that this lnvolce applies to Sübproject 106 ander MKULTRA which was duly approved and that the project ls being carrled out in accordaace with the memorandurn dated 13 Aprll 1953 (rom the DCI to the DD/A, ,and the extensioa of this euthority ln subsequent memoranda.

Datei

106 3

Research Director

C

[PAGE 6]
PROPOSEDBUDGET"!

1063

[PAGE 7]
Principal-Investigator \$9,000.00 Laboratory supplies and expense 58.43 Conference travel 727.18 Consultants 800.00 Overhead:Burden 1,414.39 Total Expenditures Unexpended Funds, December 31, 1961

I have examined and approved the submittec expenditures.

[PAGE 8]
Grant Becclved:

Expeadttures

Personnel: Principal-lovestlcator \$9,000.00 Laboratory-Techolclen 975.00 Sécretary 325.00 \$10,500.00

Conswaeable Supplie.:
Expertcental Anicals 1,600.00
Disposal Cages 570.00
Feed for Animala )75.00
Lacvrstory Supplies 800.00

Travel: Coh farence Trevel 215.00 Moving Expeuse, Principal Investigotot2.375.00

Unezcerue. funde, Pebrvary 16. 1961 I havo ereined and approved the submittod exper

/

[PAGE 9]
Centlomem:

Tk you vety euch for she roneval of your graot in the amocnt of twelve thousaod dollara (\$l2,000.00) to rua from January 1, 196l for a period of twelve (12) monthe.

Herevith enclosed le our recapitulation of tha funda received and tha expenditured under the previcus grsat. We are seading you the origiosl and one copy but will de beppy co forvard more copies if you so daeire.

Very truly youra,

Enclosures/2

Apr11 13,1961

[PAGE 10]
MEMORANDUM FOR:THERECORD

SUBJECT

: MKULTRA, Subproject No. 106

1. It is proposed to continue research under MKULTRA subproject No. 106 on studies of biological systems with particular reference to quantifying the relationship between a stimulus and the biological-response to that stimulus. Problems arising from the difference in excitability and behavioral response among members of an animal population will be analyzed. By means of animal preparations particularly\_suitable for demonstrating specific functions, evalvations will be made of biological generalizations arising from the use of one species of animal as an experimental variable. A critical review will be maintained of selected foreign literature especially that on the neurophysiological rnechanism of conditioning and related behavioral research.

2. Because-of the very low level of effort on which this program is to be continúed during the next year, reimbursements\_will be\_made directly to Mr. the chief investigator, on the basis of his invoices for professional services rendered at the times that these

106

21 May 1962

[PAGE 11]
occur. No intervenping cutouts will be required as were used in

the previous program.

3. Funds required for this program for one year amount to

\$3, 000.00. Charges-should be mäde against Allötment No, 2125-1390-3902.

4. It is not anticipated that any permanent equipment will be needed for this program.

5. The requirement for a semiannual informal accounting has been waived.:

6. All persoanel connected with the planning and monitoring

of this program possess Agency Top Secret approval.

APPROVED FOR OBLIGATION OF FUNDS:

O

106

[PAGE 12]
Cost Account 2125-1390-3902

Object Class

(When Flled In)

[PAGE 13]
Under the authority granted ia tha memorandum dated 13 April 1953 from tha DCi to the DD/A, and tho extension of this authority in cubsequent raemoranda, Sabproiscte c beea approved. and 1.000.00 of the cver-sl Project MKULTRA funds have been ooligated to cover tho subproject'a ekpcases and should be charged to cost centet as-11903902

Distribution: Origínal & 2. Addressce 1-TSD/FASS 2-TSD/RB

[PAGE 14]
MEHOANDUN FOS: CHIEP, PIMAECE DIVISION

VLRA, Subprojeat 106, Inroiee f2
A11otment 1125-1390-3902

1.  Imvoice No. 2 covoring tho above subproject 1s attached. Pannont should be made es folloves

Cashier'g chook in the sacunt of h00.00 payeble toe dravn

Cashier'e cheok in tho anount of \$l2,000.00 payable dravn on

2. Please forvard the checke to Chier, TsD/Research Branch through T8D/budget Orricer by 9 Harch 1961.

1. This is a fipal invoice. Eovever, siace it is antioipated that additional funis vill to obligated for thie project, the filos should not te cloeod.

chiet T3D/Besearch Branch

Attachrentst Inoice & Certificatione

Dietributiont Orig h 2 - Addreseo

AUUNT OF S/

-TSD/PASS 2.TSD/RB

CHECK#OIN TND AMDUNT GA B2 SROCIVED.15 MA

[PAGE 16]
KR, Suproject 106, Invoie f2
A110tment 1125-1390-3902

1. Invoice No. 2 covsring the sbovo subprojoct is attached. Payasit ehould bs maie as follcvst

Ceshter'a check ip the anount of \$12,000.00 payable drew on

2. Plespo forvard tho chocke to Chief, Tao/Posearch Branch through TaD/Ddgot Ofticer by 9 Mared 1961.

3. Zis is a final invoice. Movever, since it fs antioipeted that additionsl funds vill be cbligated for this project, the files abould not be closed.

Attachoentel Inoice & Cortificationn

Dietributiont Crig à 2 - Addressee

[PAGE 18]
15 March 1961

Gentlamoni

We are pleased to be able to tranait to you the following fundst :

Cashier's Check No dravn on the ror 480.00, deted
of
15 March 1961

Treaaurer'a Chack No or \$12,000.00, datod 15 March 1961. drava on the of the

Those fuinds represent a contribution for tho uee of your directora in carrying out the very Vorthvhile réssarch goals of your orgenizätion.

Erol, Checka\_(2)

106 11

Yours truly

[PAGE 19]
TO: TSS/OC

Thia is aa tavoice azaiast previcualy odlégated fund9.

1, Date of Obiigation:

2. Purpoaa-of Project? Studiee of

Neurophyaiological Mechanieme

3. Progresa to Datei

4. Expiration Date! One Year

S. Project Moaisor Dr A

FROMT TSS/CO

10612

[PAGE 20]
14 February 1961

MEMORANDUM FOR:THE RECORD

SUBJECT

: \_MKULTRA, Subproject No, 106

1. : It ie proposed to continue research under MKULTRA subproject No. 106 on etudles of biological syatema with particular reference to quantifying the relationebip between a stimulus and the biological-reoponue to tbat stimulue. Problerns arising from the differeace\_in excitability and behavioral responss among membere of an anirnal population will be analyzed. By means of animal preparations particularly suitable for demonstrating apecific functions, evaluatiooa will be made of biclogical generalizations arising from the use o one specios of animal as an experimental variable. A critical review will be maintained of selocted foreigu literature especially that on the neurophysiological mechanism of conditioning and related behavioral research.

2. The will function as cut out and cover for this gubproject. Tbe neceusary research will be conducted by who will submit to oummary accounting of the funds at the conclusios of the program. Aay unused funds remaiaing at the concluaioo of the program will be returned to the

10613

[PAGE 21]
3. Funds required for this program for one year amount to \$12,000.00 To thie um must be added \$480.90 represdating a four per cent service charge to the B making the total amcunt \$12,480.00. Charger ahould be made agaioet Allotment No. 1125-1390-3902.

4. It is not anticipated that any permanent equiprient will ba needed for this program, It has boen agreed that documentation and accounting for travel exponees which are reimburtable by

shall conforn to the accepted practice of that organization.

5. The requiremeat for a semiannual informal accounting

has been walved.

6. All porsounel cocnected with the plapning and monitoring of thie program posseas Agency Top Secret approval.

7. The project will he unclassified after it leaves ths

APPRÓVED FOR OBLI-GATIONOF FUNDS:

APPROVED: :

Dato:

Chief TSD/Research Branch

Attachment: Proposed Budget

Dietributioo; Original Only

10613

[PAGE 22]
PROPOSED BUDGET

SALARY:

Chief Iaveatigator....................\$10, 000.00

TRAVEL..1,000.00

INSURANCE: HOSPITALIZATION; SOCIALSECURITY........ 300.00

ADMINISTRATIVE EXPENSES.......700.00

TOTAL \$12,000.00

[PAGE 23]
Object Class

Cost Account11251313901

[PAGE 24]
16 Fobruary 1961

MEMORANDUM FOR: COMPTROLLER

ATTENTION :Finaace Divíalon

SUBJECT : MKULTRA, Subproject 106

Vador the autborlty granted la the memorandam dated

13 Aprlì 1953 from the DCI to the DD/A, and the exteaalon of

this autbority la aubsequent memoranda, Subproject l06 bae

been approved and \$12, 480.00 of the over-all MKULT:A pro-

ject fuade has beca obligated to cever the aubproject expenses.

Thie obllgatloa of funde should be charged to Allotment l125-

1390.3902.

1621

TSD/Research Branch

APPROVED FOR OBLIGATION OF FUNDS:

Research Director

Date:

Dietribution:

Orig. & 2 - Addressee

1 -TSD/OC

TSD7FASS

2 - TSD/RB

TSD/CR/4114 Fh611

106

[PAGE 25]
MENORANDUM FORI CHIEF, FINANCE DIVISION

;TsD/Bulget Officer

SUBJECT HVLTRA, Subproject 106, Inroice \$2 A21otoont 1125-1390-3902

1. Invoice No. 2 covering tho above subproject is atcached. Paymeat ebould be rade as follovst

Cashier'n phook in the aaount of sh60.00 payable to drava

1B Cashier' cbeak in the aacunt of \$12,000.00 payable to dreva on

2. Please forvard tho checka to Chief, TsD/Reosarch Branch through Ts0/Budget Officer by 9 March 1961.

3. Thie ie a final inroice. Bovever, pince it is anticipated that adaitional funde vill be odligated for thie project, the files should not be cloeod.

Attaohrentei Inotce &. Certirications

Dietributiont Orig & 2- Addrestce

1--TSD/PASS
2-TSD/RB

75

23 Pebruary 1961

[PAGE 27]
14 February 1961

MEMORANDUM FOR:COMPTROLLER

: Finance Division ATTENTION

SUBJECT :-MKULTRA, Subprojest 106

Under the authorlty granted la the memorandum dated

13 April 1953 from the DCI to the DD/A, and the exteaslom of

this autborlty ia subsaquent memorenda, Subprojoct l06 bas

been approved and \$12,480.00 of the over-all MKULTRA pro-

Ject funde bas baea obllgated to covar the eubproject oxpeases.

This obligatloa of fuada aheuld be charged to Allotment ll25-

1390-3902.

APPROVED FOR OBLIGATION

OF FUNDS:

Research Diractor

Date:

Dletributioe:

Ozlg.k 2 - Addressee

1.=TSD/OC

1-TSD/FASS

2.TSD/RB

TCn/Cn T- /A C.L L

106 16

[PAGE 28]
No. 148

Cost Account2525./001-49e2

Object Class

10617

[PAGE 29]
MEMORANDUM FOR: COMPTROLLER

ATTENTION I Finsace Divlelon

SUBJECT 1 MKULTRA, Subprojeet 106

Ueder the auibority grantod la the mercoraodum dated

13 Aprll 1953 (rom the DCI to the DD/A, and tho axtaaaloa ol

thls authorlty in subsequent moncoranda. Subpreject l06 bas

beea approved and \$21, 833,00 o1 the over-all MKULTRA project

fuade bas been ebllgated to covor the aubproject exponses. Thle

obllgation of fenda aboald be charged to Allotmant 0525-1009-4902.

APPROVED FOR OBLIGATION

OF FUNDS:

LCEREAT TPAT RNDC PA AVAECTS

Ressarch Dlrector

Dator 20100

Cletribation: Orig & 2 - Addresese

1-TSS/OC 1-TSS/FASB 2-TSS/CD

TSS/CD7(29Dec'59)

106 18

29 December 195†

[PAGE 30]
18

[PAGE 31]
27 January 1960

MEMORANDUM FOR: CHIEF,FINANCE DIVISION

VIA : TSS/Badget Officer

SUBJECT : MKUITRA, Sabproject 106, Involee #1 Allotmeat 0525-1009-4902

1. lavotco No. l coverlng the above qubproject le attached. Peyr..t ahould be made as lollowe:

Casbler'e check in the amount Ql \$84l. 00 payablo to drawn ons Bask.

Cashler'a chock lo the amouat of \$2l, Ol4. 00 payable B to drawo on a Bank p

2. Pleaae forward the checka to Chlef, TSS/Chemical Divleioo througb TSS/Budget Offlcer by 10 February 1960.

3. Thie le a Gnal invoice. However, eince it ls ssticipated that additional fuada will be obligated for thio project, the filoo should not be closed.

Altachmente: Iovotce & Certifications

Diatributioa: Orlg & U - Addressce

TSS/FASB2--TSS/CD

福

106 19

[PAGE 32]
TO: TSS/OC

1. Date of Obligation: Studies of

2。 Parpose of Project: Neurophysiological Mechanisms

3. Progressto Date

One year 4. Expiration Datee Dr. 5. Project Monitorz

FROM: TSS/CD.- Room B=10.4 ，Ex3。8612

106

[PAGE 33]
Geotleman:

We are pleased to be able to tranemit to you the following

fuade: :

C Treaeuror'a Check adrawo on the for \$841.00, dated 2 Feb. 1960. G

Treasurer'e Chech drawn on th for \$21, 014.00, dated 2 Fob. 1960.

Thoee funds ropresent a contribution for the use of your directors in carrylng out the very worthwhlle rouearch goals of your organlsation.

Youro truly.

Checko (2)

106 20

February5,1960

[PAGE 34]
MEMORANDUM FORI COMPTROLLER

ATTENTION : Finance Divieion

SUBJECT : MKULTRA, Subproject 106

Uedor the aatbority gzeated ln the miemoraudars dated

13 Aprll 1953 Irom the DCI to the DD/A, aud the extanaloa

this avlhorlty in subeezeeat memoraads. Subproject l06 has

been approved and \$21, 855, 00 of the over-all MkULTRA project

fuods hae been obllgated to covar the subproject ezpoases. Thle

obllgatioa ol fuoda ahould be charged to Allotment 0525-1009-4902.

Tss/Chumical Divlston

APPROVED FOR OBLIGATION OF FUNDS:

Resesrcà Director

Delot

Dletributioa: Czlg k 2 - Addrensee

1-TSS/OC
1 - TSS/FASB
2TSS/CD

TSS/CD/P(29Dec'59)

10621

29.December 1959

[PAGE 35]
MEMORANDUM FOR:THE RECORD

SUBJECT : MKULTRA, Subproject 106

1. The purpose of MKULTRA subproject l06 is to under-

take-studies on biological systems with particular reference to

quantifying the relationship between a stimulus and the biological

response to that stimulus. The lack of a general understanding

and adequate methodology for handling this relationship in a

realistic fashion is one of the major roadblocke to rapid technical

progress in the fields of assessment and control of behavior at

the present time. It is planned to utilize an interdisciplinary

approachin this research with emphasis oo the side of the physical

sciences. Several advanced mathematical techniques and physical

models have been suggested as fruitful research areas not presently

being exploited, Problems arising from the difference in

excitability and bebavioral response among members of an animal

population will be analyzed. An attempt will be made to elucidate

relationships between lower animals and man by comparing

physiological, biochemical, and behavioral characteristics. By

meane of animal preparations particularly, suitable for\_demonstrat-

ing specific functions evaluations will be made of biological

DRAFT 29 December1959

10621

[PAGE 36]
generalizations arising from the use of one kind of animal as an experimental variable. A critical review will be made of selected foreign literature especially that on the neurophysiological mechanism of conditioning and related behavioral research. Particular reference will be made to the recent shift on the part of the Russians from the strict "Pavlovian" view to a more realistic approach to the problem.

will function as cut out and cover for this subproject. The necessary research who will submit wiu be-conducted by summary accounting to the of funds at the conclusion of the program., Any unused funds remaining at the conclusion of the program will be returned to the 3. Funds required for this program for one year amount to \$21, 014,00. To this sum must be added \$841.00 representing a four per-cent service charge to the making the total amount \$21, 855F00.Charges-should be made-against-Allótment No.0525-1009-4902.

4.It is not anticipated that any permanent equipment will be needed for this program. It has been agreed that documentation and accounting for travel expenses which are reimbursable by

B

10621

[PAGE 37]
It is: proposed to mount the initial phases cf a progrom aimed at an eventual clarification of the fundaniental aspects of the problen of stimulus- response relationship in biological systems. The present theoretical models and concepts in this area are\_not only inadequate but also represent roadblocks to further progress in the evaluation ena control of biological syatems, including man. (See work such as Loeve, S.-Science, 130, pg 692, 1959) The development of practical tools for this work in the for of chronic animal preparations with pemanent-septal electrodes has-lately opened the door to effective-researchin this-area

Initially the work will consist of a careful literature survey, especially of the Russian literature, coupled with-various classical types of conditioning experiments uaing the chrbnio electrode preparations.available from animal guidance programs.Later-the results of these experiments will be pooled with those involving standard drug effects on the-sone proparations to design critical experiments aimed at providing new abstract models for these phenomena.

It-is-planned that during the firat year one investigatien can complete the literature work and with a minimu of help carry out the initial-animal studies required for the design of- severel definitive experinents to be carried out during the second year. The foru of these experiments cannot presently be visualized because of the inadequacies of present knowledge.

PROPOSAL

10022