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1 will be attending a meeting of the Federation or Societies for Experimental Biclogy and Medicine in Chicago, on April 15-l9th and 1 hope to see you there. in checking the program 1. note a number of papers which are of some interest to us.

1 am enclosing copies of the following reports which 1 think will interest you:

1. Effects of Acute Administration of BAS in Man,

2. Attempted Blocking of the LSD Reaction with BAS,

3. Acute Effects of Large Doses of BCL in Man,

4. Attempts to Block LSD with. BOL Given Simumtaneously with LSD,

5. Attempts to Block the LSD Reaction by Pretreatment with BOL for Two Days.

You will notice that the results of the last experiment were disappointing, probably because of the small number of subjects, and because 4 of the 8 subjects did not have significant mental reactlons to the doses of LSD used.

In the near.future I hope. to repeat the experiments with BOL, and also to test the effects ofBOL given 2-L hours before LSD. i also hope to study blocking of the LSD-effect in man with Dibenzaline.

When the results are available i will drop you a line.

With kindest personal regards,

Yours very sincerely, Harris Isbell, M.D. Director

A-353

Department of HEALTH, EDUCATION, AND WELFARE• Public Health Service NATIONAL INSTITUTES OF HEALTH 10 Apri1 1957

IN REPLYING ADGÉTSS THE NARAL IT O ENTAL HTALT AODICON BESCAR CENTER U.S. PUOLICHALTH SERYICE HOSTAL P. O. Baz 200d Y

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Hi:rn Enclosures