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Report Prepered by Harrls Isbell, M.D.

NR:113:149

CONTRACT: NAonr 181-53

ANNUAL RATE:ARSE

CONT RACTOR : U. S. Publle Heelth Servlce Natloaal Instltute of Mental Health Addistton Reseerch Center, U. S. Poblic Hicalth Servlce Hospltal, Lexlngtoa, Kentucky.

PEINCIPAL INVESTIGATOR: HarrIs IsbelI, M.D.

Ascistants: H. F. Freser, M.D. G. D. Vaa Horn O. A. Keily 9. H. Eelch M. L. Glces C. k. ürowa Russclt hoss, Jr C. H. Hoga

TITLE OF PROjECT: Addictlon Licbillties of Syafhetle Substltutes ior Codeine.

Cblectivel To fiad a synthetie, cnalgesle drug which would be sofe, froa the polnt of view of toxicity end eddictlon llebillty, es Is codeine.

ANNUAL PROGRESS REPORT

ONR:441:FHQ:mre N.113:149 Ser. 12560

1 January 1955

For Perled: I January 1954 to 31 Decsmber 1954.