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We recently obtai:aga small supply of an interesting substance in the cannebinol seriesh appears to be extrenely potent. I have now given 11 subjects dcseir 1 to 2.5 mg. of this drug. The first two petients promptly. identfied the effects as being like those of marihuena and, naturally, all patients aince the first two have expected marihusnalike effects. Patients begin to report the subjective effects within 2 to 4 hours. Effects appear to be most prominent 6 to 8 hours after the drug is administered and are still present 24 to 36 hours later; and in scwe cases even longer. Description of the subjective effects is very vague, except that the subjects are very positive they resemble those of marihuana. They gay the effects of 1 mg. are equal to one or two cigarettes of the best rarihuans, except that they appear slowly and persist for a very long period of tire. They are described as consisting of a sensation of mental relaxation accoupenied, however, by"physical"tension, increased appreciation of music, jokes, and other things. The characteristic behavior observed in marihuana smokers (giggling, silliness) has not been seen, but the experinental situation has not been conducive to the appearance of euch behavior. No hallucinations, perceptual distortion, etc., have been reported.

With larger doses (2 to 2.5 mg.) the syoptcas became quite unpleasant in 6 of the 1l subjects 6 to 8 hours after administration. The uapleasant symptoms included dizziness, feeling of great weakness, markod drowsiness, nausea and vomiting. "Weakness has persisted for 48 to 72 hours after administretion of the drug. One patient feinted on going to the bathroom the morning after having received a 2-mg. dose.

Neurological examination.in these patients so far has been negative with the dose used. However, gait could-not be tested in some patienta who becama so weak they refused to get out of bed. There is a very definite tendency for the pulse rate to beccme rapid and a tendency for the blocd presaure to fall. The results suggest that some cardiovascular disturbance, possibly postural hypotension, may occur. I hope to investigate this in the immediate future. Because of the appesrance of these toxic reactions, I am not planning to increase the dose beyond 2.6 mg., in the irmediate future.

It is zotevorthy that the patients shov the characteristic marihuana facies, which consist chiefly of marked conjunctival reddening and pseudoptosis.

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