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Dear Doctor:

Inenmwer to your letter of September l6th concerning the p u hit is made by the I have had considerable difficuity to get a suffi-Ciant supply of the drug to have done a large series of casos with it, but we bave had over l00 patients for dental extractions and it has been a satisfactory drug for these patients.:

Ve are able to use the drug in either anasthatic or analgesic done, usually vith prelininary, medication on dose.  The dose on Ior adults ugually ie If one will use a mixture of by inhalation one can reduce the dose rof to one-third or oue-quarter as much of it as is used wben used alone. It appears-that-the drug vlllbe particularly good for dental ertraction or. dental-pain.

The paper that I prepented at the ill be pubiiabed in It contains such,data as ve have'collected to date. Hy' impreasion of the drug is that it produces a degree of skin.analgesia that I have not seen previously vith small doses of other druge. The recovery period is short. Thereis little effect from, saall doses on blood pressure, pulse rate, E.E.G. or E.C.Q. tracings. An overiose of the drug, euppresses reepiration and as a result a state of anoxemia develops and you are aware of vhat prolonged anoxemia will do to a patient..

Yours truly,