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As part of our research progrom for the coming fiscal year tinly 1953-luiy 1954} we are plamning to condvct a study of the mental and ofher pharmacological effects produced by fhe chronlc administratloa of the dlethyl-amide of Iysergic ecld. We would appreclate any Information you have conceralag this comgound, as well as any advice and suggestions concerning the proposed work. We are perticularly Interested in finding where we might.obtain a reasonably large quentlty of the drug.

We also hope to lavestigate the acute and chronic effects of a.number of derivatlves of-N-allyinormorphine ta man. We are garticularly interested in the levo isomer of 3-hydroxyg-allyimorphInan and the 3-methyl ether of N-allylmorphInan. Another compound which may be of interest to us is N-propyldIhydrcmorphine.

Finally, we hope to investigate the effects of diet and of constituents of food on blood alcohol disappearance curves. I would appreciate your advice concerning the best methods of determtnino blood alcohoi.

Very slacere'ly yours,

Harris Isbell, M.D. Director of Research

DEPARTMENT OF HEALTH. EDUCATION, AND WELFARE

TWX CODE NO LEXKY 477

IN AEPLTINO.AGORE1S THE XNEHCREXKOMROX PUOLIC HEALTH SERVICE HOSPITAL

PUBLICHEALTH SERVICE.LEXINGTON,KENTUCKY30Apr11 1953

Hi:rn

DeclassifiedyES 197737475 date 4 FEB 1977