[PAGE 1]
Joesuthr.ua Farcard erty. the rushreen "teonanactl"

Atsu n as navin Cs stimulant

a tos calaa.

shrm

sant d haliucinonie notn.Sancles of

Peseolus d ancther no cntified s scimuatine mushrooa were sent

to us ty Pr. Paracics-kinarn via tr, ra Kiopfer, Kexiuo. The

Fancolns shew so c:ieohir activic, te nnicentified raterial

s clas acne icn is the cne che Wassons

ainan iianiscussicns have ben

crld wit.s aasser e lsrd ae rosnlts of bis

exptdicien. 'n searer othe nallueinorenic nuchroons, At present,

r. Yeare  t. roty of eiaar, à centact of rurs as wel: as

ons ot the grcup vith Nr, Wassen, is working on extracts of Failoeybe

for us.

xrast eat e ccon

rrateerren belew

5. vtrseen t nexano. ani rnay iephaiizatac zacias

eeexima watesr scls), Fiving

tr a.

B-129

153

:P-54

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-

stlocyh cauralescens.

etfoetn ana..ne ie sur findings:

aed actity 1

ty E:

ossaroe  m/k

ned.l

fe.

Ithne cser

renesedose

s rered in

one exgerin. dee ieveis. anears tF lc. e7e fatled

so ha

he interes … dicfr Crem Mescaline er 7

13 in a ns in he

msthan

nocie avityan

.

ceater seisurs

LACTY A

1

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(seaf'e

protce sicnlicani X ,ahenszen anting re.d-level,resslesona.u, are a:r tensien were evident.
Sur trpressiens in 3251- y sunjectivs. lio cbvious changes
in hehavor sure arrarant altncuch a tinos the crservers thousht that
slight behzviorr changes vere ncted; however, these ecvivocal effects
inJicate that nr recerded observaticns may be qaesticned. In the
ronkeys, intravenous doses of 25 or 50 F/Kg Sailed te eroduce bohavioral chenges or siznificant side cfreets. It should be rentiened here that this sarple of SK lie. 6778 hal been in the laboratory fer four months erd may rave lost potency. Cvernll Sarzary:
It is opparrnt fran the tat presented that a: tore not able to docnstrasa any urusne! thoresolcrie esimy er siriaistratien te rats and mace. He.ranrereine' (in contrast to LsD and d  teriti s uch s these sen after .

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t,ivaticn,pantaar,pprehensicn rydri.cine,veeltaung, slisat salivatitn: aprn,  effces n mpite.

no stáe =f-2z

B. Psilcoyhe c.lrcens - Suple So. è uavti te D. Macko cn 211/59 b Dr. 1. Techte

1. Dopa Raxce 2n De2e

Intravencus doses of 25, 50 or 75 m:/Kg vere adninistered to each or
chree dogs respeetaveiy. after inje,in all of the dzs exhibited sida inpicative of behavior
Fopottons; however, wietter thece
chaneer emery. 1t the 25 r/z level, and arr-hensicn, Jaw Fevement Lirn, thte icimal sat qviotly. ri, resed hie head tovord ere iekn for sorethics. a iajection. A dose of Callovas

[PAGE 5]
fservation prici. A dese et Tb eyx- pohoea oaiivation, diarshea, ataxia, ilr Le zodnusa, silited ppils, jas roverat, roprehonsien, body caakee ant an initie tracieet stirelatier. Perther, this daa appearod so bo locking for sorythe; ead stcod facing the brek of the caru for three to four heurs.

In Whese arirals, Ck? Na. S775 prscusd vsible biclorlcal side effects Selleving doses er  to Erg.Xe, intrarenously.

Cne cn only speoulate abeut the cerneccins er these effects and the , hallvainogenic arfests reportca in ran.

T

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2. 2 deeas (Sere N, ) ia Dara

In ord  t reie ere denitive haflucihecenic er biologien sotiiy. a.iv nevasin er sz2 Ho, 6779 wes lessiated in degs aa res fr ro ate e felledr doce schedule.

:5 3 2 à 5 EC 200 1 7. 80
Deg 2 400 7 7
7 2 43 25 50 200 7. t

Cur daba is summrtod in Paolc Il.

Results:

No significant ciurgo in the behavier o:" the nonkeys vas observed frem caily doses o: 25 to 200 rg/Kg of SKF No. 6778, intravencusly, fer fonr. days follei by cne dore af fco raSg, orelly, on the rifth day. In thu dcgs, questionibls behsvicral crnces vere etcerred in sene of the aninals (Bogs Ne. 5, 6) in doses below (00 g/Kg, intrivencusly. Howevr, doses er aco ng/Ke, intraveneualy er ec0 rg/kg, orally, produced considurable side effeats thich care characterigea by ataxia, cryint, apprebansion, srerors, nydriasis, ctc. Às shown in Chart I, it appeared to the obser that the side efteots aftur Roo pasir, crally, vora rore intcnss than ther following o r/e, intravnously. tore, on the firth wnd lnst d the antroccaved: sHo. 677b, erallyIn the d,ioral changs and side feve 2orthe dos da btee sise ee.

-7.

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ch srrnteel prodteed stde effosts and sene beeavieral channca in dirs felleuin me-ive doses of 5 to 200 Tg/Kg intravencusly or lco to tco re/ke, arnily. Uthough cur cbservatiens are purely subjective and ean lesd oniy to spucuiaticn cercsrning the hallucinatory effect of this substnnee in nia, we have sstablished that Pailooys caerilezccns should be relatively non-toxic.