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1. Thank you for your letterof.3 August with enclosures. was,very glad to hear from,you, even though indirectly. le was also'pleased to receive. the "large"document"(which he is very much interested in. He is personally interested in the group and two of the leading players of that group visited lim at tho in the past month. He would be extremely interested in receiving the seeds you referred to inthe third paragraph. Again hesayalhehas,been,trying to get some of these for alongtime. 2.In regard.to yourowm olassified report,"he 'had the folloving camments.to make: durtE There is,no question but what this statement.,is an extremely adcurateone tothe point where recent conferences on the general subject have concerned superintendents of hospitals with regard to newer methods in a separation fasion for follow-up of patients reoeiving these drugs.

l-b.:From our studies I would agree complstely with this statement. However, there seems to be some-indicationthat in'most. instances while there is"merely a blockagə of the pigment this,is due to atremendous increase in intraductal-pressure: as a consequence of theispecific action of the drug on smooth . muscle. I will'be very glad tosend to when it A tis published, research,bearing on this point.

.We are currently undertaking deep electro-encephalographic
load studios of this activity; the prosumption is that it is not.chlorpromazine'responsible for the convulsions but rather an inciting of latent,convulsive potentialities in
patients with epilepsy. 1 Iswould:agree with this statemant comnlatalv.

In a recent discussion with concorning tho role of C indoles nt a moeting hers, thore was considornble discussion on this point.'It'should be omphasized that thís is merely his hypothesis and the fact.ofyanindole."toxio.factor". is . still purely conjectural.,

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l-f. The nicotinic acid studies have not been able to be reproduced by other groups attempting the same work which the Troup has done.

2. There is a publication recently made on the gencral subject of psychopharmacology reviewing the,subjəcts under roview here.

11.:Our work confirms the impression stated horo by that there is no evidence of spindling in the electro-. encephalograph as is produced, by barbiturates.

15-25'on the general subjoct of Rauwolfia derivatives: Kline's work has been roported elsewhere and one entire issue of the proccedings of the New York Acadomy of Sciance is devoted to an exposition of his work. There will shortly be published a symposium reporting on a conferance held by Smith, Kline aùd French in Philadelphia on the subject of thorazins and Rauvolfia administrntion which elaborates on the points made under this gqneral heading. 7 1.

26.. I would agree with this skepticism of the author of this with regard to his statements in No. 27,

30. Comments on the paper by In ourxporience with normal subjccts we encountereu the same phenanenon in that tie intensity f this -subjective experience seems to be a function of tho attitude of the subject and his relationship to the particular surroundings-at the time of the experiment.

Concerninr, the isolation work which has been undertaken at

Fit has beon my impression
that'despite proliminary reports on this general subject by
a number of investigators that in recent times there seoms to
have been an unusual switch in interest with a decrease in
number of publications on the effects of isolation in humans.
It seems to mo to be of importance €hat this field has been
neglected by pioneers in the subject -- or perhaps there are
ulterior reasons! i

3. fstated that whose representative was at the that day, had given him some more intereating. material for his attention.

. 4. I was vory glad to get your letter and enclosurcs, as L am suro it has 'been a means of not lctting our contacts co stale. I also want to say that everything is going to personally, and your lotter of transmittal was destroyed by me personally.,

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