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In accordance with Ray's telephone call of Cctober 19th I have the following suoolies of the materials on hand:

Agroclavine (V-A-18), 440 mg,

Dihydroagroclavine (V-A-19), 450 mg,

Dihydroergokryptine (V-A-20), 25 mg,

7.9-Dimethyl-9-hydroxy-4, 5, 5a, 6, 8a, 7, 8, 9-octahydroindolo [4.3-fg] quinoline (V-A-2l, or Lilly 23194), 315 mg,

Elymoclavine (V-A-22), 100 mg.

You may have any or all of these materials since, with the exception of V-A-21, I can get additional supplies from Dr. T. Yui of Takeda, Japan.

We have never studied V-A-20 here. It was sent, without our requesting it, in the hope we would test if for adrenergic blocking properties.

Key reference on numbers V-A-18, 19, 21 and 22 is: Yui, T. and Takeo, Y.: Neuropharmacological studies on a new series of ergct alkaloids, Japanese Journal of Pharmacolegy, 7: 157-161 (March) 1958. The only information I have on V-A-21 or Lilly 23194 is in the form of thermofax sheets sent me by Dr. Slater of the Lilly Laboratories.

(⑥③)

B-326

181

Nudlaasà Isstitute of Mearsł Healtà Addiktiea Rsasirst Centar U.5, Pubüe Hezilh Sertics Hespita Lezinrtea, Keatucky

DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE

19 October 1930

PUBLIC HEALTH SERVICE

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They indicate LSD-like effects in cats and rats, but in man this compound had potent hypnotic properties.

Looking forward to seeing you soon,

Very sincerely,

arke Harris fsbell, M.. D, Director

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