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FROMI ere, H.D., Consultent
SUBJECT: IFORMATIOR FROM FUROFE RELATED TO TE LGO-DEPRECSNTS 6 Auguat to 29 August 1952

SEcTIon A - Sueuarizing Report

SECTION B - Deily Notes

Septozbor 4, 1952

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Whilo giving sovorel lcctures in Europe during Auqust, 1952, an opportuuity was affordod to obtain Purther inforustion on tho-ego depresesnt ("truth serm") under the Medical drugs in lino with

Research end Dovelopnent Board. The discussions with. the several Ary Attechés
described in tie attached Delly Rotes wero suzgested by the thoughtfuness of sfof the Office of the Durgeon Generel end vere grostly furo, who sent a notice of y
thured by the courtey of
visit to tho Ary Attachés zentioned.

It seuzs cloar thet the ranificstions of this subject (the ego depressent cgents) ere far vider than they had seezed to Es at least at the begirming of our work in this field. It is evident now that the egents wich fall sithin this group could profitably be attacked fron three direoticns:

(1) as aies to obtain sapprecsed infomatien (there are thorepeutic as vell es Dilitary sides to this)

(2) as tareats to security hen used by en cey cgent (they jeopardize integrityj ve need to kmow the sigas end sy=ptons of their use for security purposee)

(3) es tosls of biological varicre or cheoicsl varfera (the lysergic acid derivatives, coning as they do fron orgot could bo considored mder oither hecäing)

In eeplier reports to the Surgcon Gexerel I have dcalt sufficiently vith itens
f1 end £2. (See Frogress Roports Csravey
tools ray alreay be wnder study. Tey mhould be To dose of the egent we ero
now working on, h.S.D. 25 (a dietyl aaide of lysergie ceid), is so mall, in gaa O

1.3.10 lyx.

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(thousendths of a nilligraa) ono cen calculats thet tho vater cupply of a large' city could probably bo disestrously end undetectably (until too late) centaainatei vit quentities apparently readily avellsble, (Soo rczarks of ProfessorCs, opakey esa 24 to 28 August, in tho atteched Daily Notes) It should rot be a iiffirilt trick to sink a small container of this sgent near the uain outlot of water storago reservoirs, and the container arrenged to "excrete" a stoady flov of the material over a poriod of rany hours or deys.

If the concept of contanizating a city's water cupply soezs or in actual feot is found to be fer fotched (this is by no zeans cortain), thero is still the possibility of contazincting, say, the water supply of a bomber base, er zre cesily still, that of a battleship.

For ceaturies in Europe outbrecks of "The Eencing Madzess" hcve been va-iozsly ettributed to maos hystorie, to ergot poisonins, cnd so en. Vithin the yeer such an outbreck occurred in France; Tis waa attributed to the use of infected srzin. There is soze reason to believe that the grcin invoivei crze by nisteke froa. a rea in Frence shere ergot production for exporinsntal purposes is being carried en. (See the ettached Daily Notes, Wsg 21 to 24 August.)

Our owa current vork contains the strong sugsestion thit L.S.D. 25 vill pretuco hystoria (uneccounteble lcughing, enicty, ete.). While our stusies so far have been carriod cut in isolated indivicuals, one at a tine, it is vell kow that hystcria is conpoumded thca several vulssrable individunls cre togsther. Te lytergie ecid derivatives can produce a temporary stcte of. severe inbalance, hyaterie, insanity. It roquires littlo inagination to realize mat the œonssquoncès night bs if a battlesihip's crew vero so affected.

Mhile biological varfsre is outside of  field of conpotance, I understtai that a chief problez is to got toxins in pufficient censcatration in centact vith a nimificant nuaber of ptople. The use of lysergic acid carivatives indicutei clovo

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T.5. 101

studr. Concoivably this ight be en wausually norpinul cgont of werfaro: teigorarily mulllrying the individual's offoetivanees, but not perczently daaging hin.

. I hava outlinod the abovo points in e sonovhat dogaatio way to nake the point. clear. Needlsss to sar Luch nora wors needs to be done. Ve need to hov, for exosplo, if oräinary chlorination of tho water vill oxidizo the lysergic ccid derivetives. Evidantly the heat raquirad to bke brcad coes not. Lhat cro tho effects of eir, light, ete. Are there cntidotes, ete,? In tha coses we havo becu using, about a gaua sar kilogran of tody veigat, tho raxino effect is attcinod. in about tuo hours eftor ingestlon by pouth, cd the éuratioz of effectivocss is about six hours. Ve need to imov the effoots of large eoces, of prolonged ahinistration of sall dosos and so cn, to nention.a fev patters for stucy. 9.

Tece egents cre boing studied by soze 200 investigators (sco yotes frz Csrp 人 rs 24 to 28 August) probably on both sides of the Iron Curtein cowtrios. I sarnestly lope that tho United States vill not get behind in this fizld for vont of on ortenizod plen of attack.

New ogonts are boiag prepered cortainly in earobablystsmse Lugust 1952, tnd B 24 to 28 August) Professor nes pronised to send ne for study tho new L,.E. (a nono ethyl enide of lysergic acić). Tis is snid to ba noro excitont to nomal individuals thrn is L.s.D. 25.

MISCFLLAIZCUS OBSERVATIONS

1. The dinofiegellatos. Ses Daily Notes,E, 10 to 14 August.

2. Persisting insenity followiag two exçosures to the war nervo gases. .Inis oquitoenl situation in roferred to in the Padly Notes, enrgay 14 to 17 Angust. It will bear further study.

3. Dr.  associate of Professor is

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cozins to Azerica for thrcs nonths.. Ve vill errivą ebout October l5. Port of this tize ho will bo  house guest and could probabiy fill in a Eood ma zore itens of desired inforation.

If inforation is vented about Professor prasw interests (sco Doily liotes, 1
p 21 to 24, lugust, endrestsea, 24 to 28 lugust), a good bacsground
could bo lcid in the forthconins visits to ry laboratory of scieatists fron the o with coatizuisg contacto with Dr essociato A.. .

Within soze months I shall have a visit fron Dr. xsyof the He is skilled in the fiold of the wer nerve geses and has in the past telked to re epporently very frealy of His work.