[PAGE 3]
B 1182S.32 Pd chacks:458.66 to Recipts 11.36a66

16 Sept 5s "Foe stevices" 23,950.68 Checks:23:039.34 2 Roceipts 27sept. 917.34 (abo signed for 30.971.22)

③

checks:\$ 17.022.72 Pacipls 17,732.00 4 709.28

13 Doc 56 \$ 29, 816.66 Becipts 31,010.53 Chocks. \$ 1.193.37

[PAGE 4]
93

21 Aug S9

$$
\therefore 4 8 , 5 0 5 , 4 0 .
$$

$$
\begin{array} { r l r } & { } & { C P _ { 1 0 0 } ( k _ { 3 } , \ldots , 4 0 , 6 4 0 , 0 0 ) \widehat { \{ \phi _ { 6 } \ldots \phi _ { 1 5 } \} } \ldots } \\ & { } & { 1 . 8 6 5 , 6 0 \widehat { \ \phi _ { 1 6 } } \ldots } \end{array}
$$

③ 31 MAR 60

$$
1 5 . 6 0 0 . 0 0
$$

$$
\begin{array} { r } { \iint _ { \Delta } d \cos \psi _ { 1 } \rvert = \frac { 1 3 } { 2 } \overleftrightarrow { 1 } \overleftrightarrow { 2 } \left( 2 \overrightarrow { \overrightarrow { \overrightarrow { a } } } \overrightarrow { \overrightarrow { b } } \overrightarrow { \Bigg ) } _ { \overrightarrow { a } } \right. \underbrace { \partial \overrightarrow { \overrightarrow { a } } \sin \overrightarrow { \psi } _ { 1 } } _ { \overrightarrow { a } \overrightarrow { a } \overrightarrow { b } } \cdot \overbrace { \overrightarrow { b } \overrightarrow { a } \overrightarrow { b } } ^ { \cdot \overrightarrow { a } } \cdot \overbrace { \overrightarrow { b } \overrightarrow { a } \overrightarrow { b } } ^ { \cdot \overrightarrow { a } } \left( 2 \overrightarrow { \overrightarrow { a } } \overrightarrow { b } \overrightarrow { \Bigg ) } _ { \overrightarrow { a } \overrightarrow { b } \overrightarrow { b } } \right. , } \\  \overbrace  \overrightarrow { a } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { a } \overrightarrow { b } \overrightarrow { b } \overrightarrow { a } \overrightarrow { b } \overrightarrow { b } \overrightarrow { a } \overrightarrow { b } \overrightarrow { b } \overrightarrow { a } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { a } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow \overrightarrow { b } \overrightarrow { b } \overrightarrow { b } \overrightarrow \overrightarrow { b } \overrightarrow { b } \end{array}
$$

$$
\tan \alpha : 4 8 7 . 5 0
$$

④ 25 Aug60

$$
\begin{array}{c} \begin{array} { c } { { \begin{array} { c } { { \mathrm { 0 } } } \\ { { \mathrm { . } } } \\ { { \mathrm { . } } } \end{array} } } \\ { { \begin{array} { r l } { { \mathrm { 3 } \cos { \theta } . 0 0 . 0 0 . } } \\ { { \mathrm { . } } } \end{array} } } \end{array} \begin{array} { c } { { \sin ^ { 2 } \theta \cos ^ { 2 } \theta } } \\ { { \sin ^ { 2 } \theta \cos ^ { 2 } \theta } } \end{array}   \end{array}
$$

$$
2 . 8 0 0 . 0 0
$$

10 14 WO√ 61

$$
\begin{array} { r l } & { \underset { \mathrm { i } } { \underbrace { \operatorname { o g l } _ { k \in \{ k _ { 2 } , \ldots , 2 \operatorname { o g m } , 2 \operatorname { o g } } } } } \sum _ { \mathrm { o } , \mathrm { o } , \mathrm { o } , \mathrm { o } , \mathrm { o } } \sum _ { \mathrm { o } , \mathrm { i } } \left. \hat { Q } _ { \mathrm { o m } , 2 \mathrm { o } } \right. _ { \mathrm { s } } \leq 2 0 , \mathrm { g } \cos \mathrm { o } , \mathrm { o } \dot { \mathrm { o } } .  \\ & { \quad \quad \quad \quad \quad \quad \quad \quad \quad \quad \quad \quad \quad \quad \quad \quad \quad \quad } \end{array}
$$

285.Φ6.6.9 259,066.60

[PAGE 5]
Aunoer2nons.

[PAGE 7]
(UI PU)

[PAGE 8]
Gentlemen:

We vish to submit a Final Finepcial Report for Pesearch Supported by the

Totil Fuoda Received

We hope that you can give favorodle consideration to this. report.

I certify that services or materials have been satisfaotorily rpceived and the exponditures were incurred on offictabusinesscosrs

[PAGE 9]
Referring to your letter of May 26, we find on review of our files a letter fron Professor written on June 15,l960, specifically requesting a grant of \$15,000 for the period of April through September of 1960, and for support at an annual rato.of \$20,000 thereafter.CAgain, in a letter dated Óctober 31, l1961, Professor requested \$8,000 for support of Professor work YoF the period October i96l to October 1962. In the aame lettor he explained that he would use the remainder of the graut for that year to support Drs of his laboratory. In a letter of October 1961, Professor Poquested a personal grant of \$10,000 for the poricd of hismbhatical grant was never approved by the

It would appear from these facte that while the has, porhaps, beon somewhat informal in itB aduinistrative practice, the cace in point, namely: tho May 1962 payment of \$7500 to the University of was, in fact, uniqug in that there ig no fornal request in the files of the xo support the specific grant and it mus considered an inadvertent overpayment by.the

We would appreciate any further conslderation you may be able to givo tbis matter.

Very truly yours,

Juno 18, 1904

[PAGE 10]
This letter is in response to your letter to me-of-May 6,-1964. In accordance with your request-to-recheck our. records for possible over-. payment-of\$7,500:00 we subait the following data:

Remittances received compared-to-approved budgets:

[PAGE 11]
-Total Remittances 5282,290.00

The budget-requests after September 30,1959 vere made informally by telephone.-Additional requests to reduce deficits, over and above the budget, were likewise granted on the basis of telephone conversations.It is a request of this nature, that we feel the \$7,500.00 received during May, 1962, to be.

On January 22, 1964, we subnitted to you a report of expenditures which shows that.research.expenses of \$282,290.00 were paid from Crants. Actually,there wasa small deficit in this account, Which the University absorbed.This is not showm on the report.: A photo copy of the report is attached,

Dr has reviewed his records and searched his memoryto"determine the sequence of transactions and he concurs that the above is about as precise a determination as we can make at this time. le has in his possession a memorandum of a telephone conversation with your. office in which he records the request for.the \$7,500.00 in question.

It is unfortunate that\_we\_did not continue.a complete exchange of written requests and identify the period of research to'which your support applied. Such docunents would havebeen of inestimable value-in-answering vour inquiry. :It is our sincere belief. however, that the \$7,500.00 check received during Hay, l962, was not a duplicate payment and was your response to an informal request, for additional fumnds. If you feel that the matter deserves more attention, or that we have not made a satisfactory explanation of our accountadility, please do not hesitate\_to inquiré. further.

Controller

[PAGE 13]
Projectam MKULTRA 46

Date Initiated: 24 March 1955

Date Expires:

Funds - current year: \$23,400,00

Purpose: To study the metabolic fato and distribution of psychotropic drugs in order to elucidate their mode of action.

Status: This la a continuing project, Current work is on totrahydrocannibol into which radioactilve carbon is introduced.Further work is awaiting the arrival of an appropriate post-doctoral student.

[PAGE 15]
6 100001卡

01612551 77501f 4101129 ES091E 002310 1905680

097816 oo00c aon 795781 282677 sosoc jE416 99856 aczb9sp 00020 0S21SE 0004914 (9591968 775 pEESOEE 1 779%11

3 3
of E 2m mul6 675

[PAGE 17]
Enclosed please-find a brief-report-of-our activities in the first six months of this fiscalyear.Inadditior thesis has been sent to you presenting in-detail-some of the pharmacological properties of certain-tetrahydrocannibols.

tyorapptications pending for.grants-in-aide fron the If these two grants are activitated \_and if the of the continues after October 1960 in t ange of \$15,000 to-\$20,000-per-ycary-we can continue our present level of research and in addition undertake thc metabolic study of a radioactive tetrahydrocannibol. as planned. In the meantime.we\_need approximately \$15,000 for our current work in the șecond six months of the fiseal year (Apritthrough September-1960) 1 hope you will: find it possible.to\_continue\_your:generous-support-to:this extent.

Are you planning to visit us in the next few months? I am sure you would be pleased at the research activity you are sponsoring,

Yours truly,

46.5

WARNING-NOTICE SENCOIVE INIELLIGENCE

[PAGE 18]
28 October 1963 Date

Branch BB Category. NEW MATERIALS &CONCEPTS X)

N.A. Item Classification. N.A. Project Title

Unclassified Project Crypto MKULTRA Crypto Classification

Branch Project NoN.A. Project Engineera

Dr, Contractor.

MKULTRA\_46 Task No.. N.A. Contract No.

MKULTRA Date Initiated 6 November 1961 Type of Contract

Cost\_ \$20,000,00 FY 62 Completion Date. 5-November 1962

Elucidationof the site-andmechanism:of actionof LSD using isotope and tagged molecules, establishment of mothodsforisolating LSD and its metabolitesfrom Biological materials and their identification.

Status;Terminated

Requirement: Internally generatcd based on need to obtain fundamgntal information and elucidation of the mechanism of action of a chemical compound used in selected operational situations.

[PAGE 19]
REQEIPT

Receipt is hereby acknowledged of the following checks:

Trcasurer's Chech dated November 29, 1961, in the amount of \$20 000 00, drawn on the E payable

Cashicr's Check , dated Noyomber 29. 1961 in the amount of \$800 00 drawn on the payable to the

A Date: yf dec 1961

D

46-16

[PAGE 20]
26 April 1960.

s forwarding herewith a check lor \$15, 000.00 to provide additlonal support for your reaearch-program-during the present grant year.

It is belioved that the fundamontal information obtaiued from your research will bo of inestimable value.: Your studies on the distributlon and metabolic fate of selected compounds haviog significant central nervous system activity will provide informatioa requlred for more productive reaearch leading to improved compounds.

A summary accounting for the period from 1 October 1959 to 30 Aprll 1960 will be appreciated\_at your earlieat convenlence

[PAGE 21]
MEMORANDUM FOR: Chief, Finance Divlelon

: TSD/Budget Offlcer

SUBJECT

; MKUL'TkA, Subproject 46, Invoico No, 10, A1lotmcat No, 2125-1390-3902.

1. Iavoice No. 10 1n the amount of \$20, 800.00, covoring tho above subprojoct is attached. Payment should bo made as follows:

Cashler/B.cbeckla the amount of \$20, 000.00, drawn
on a bank. E

Cashlar'a check in the amount of \$800. 00, drawn on bank.

The chocke abonid be made payable to the

2. Please forward tho checke toChief, TSD/Research Branch throvgh TSD/Budget Officer by 28 November 1961.

3. Thie ls a finai invoice. However, since it is anticipated that addittonal unde will be obllgated for this project the files should not do closed.

Attachrucntst Involce & Certiflcatioe

9618

14 November 1961

[PAGE 22]
CERTIFICATIONS

(1) I ts keraby seruiled thas this is Invoice f10 apptying ko Sub-project No. 46.e4 MKULTRA, thas perfernaace is satisfactory. that servises are being arcomplshed in aceerdance with muteal agreements, that à detuilad agenda.cíthe pzyments ecd receipts ia cn Ale ia TSD/RB, thet this bil is just and correct aod that paymnent theract has nct yat been made.

Dare14 Novembor 1961

(2) It is hereby certifted that this invoice applies to Subprojeet 46 of MKUlTRA which was daly approved. and.that the project ia being carried out io zecordance with the memorandum c€ 13 April 1953 from ths VCI to the OD/A, aad the extens2cn of this suthority in subacquens Aem0r 20dh.

46-18

For Services

INVOICE

\$20,800.00

Rescareh Directer

[PAGE 23]
D

(When Filled In)

46-19

No. 842

Cost Account 2125-1890-3902

Object Class

[PAGE 24]
KEMORANUM FOR: TER COMPTROLLER

ATTEFTION : Finance Division

SUBJEOT : A, SubproJect 46

Uoder the authority grected-in-the memorandwo dated 13 April 1953

troa the ICi.to che DD/A. and the exteneioa of this sutterity ia aub-

sequent qemorenáe, Subyroject 46 hes boen approved, and \$20,800.00

of the over-sll Projeet NITRA funds have teen odligatei to cover the

2125-1390-3902 suboroject'a expenaes and shoula be charged to cost center

APPRONED POR OBLIGATION OF PUNDS: A

NOV 6 190 Date:

Distribution: Original. & Cu : TSD7PASS 2 2 - TSD/RB

O

46=2a.

Date: 24 Octobor 1961

[PAGE 26]
1. The purpose of this supplement is to provide additional

funds for the support of a research program being carried out by

and associates at thc University of ollege of Medicine and provide for professional and related services by Dr. on,specific problems of pharmacological and toxicological interest to TSD.. The.program provides funda mental information and elucidates the inechanism of action of certain .3-t psychotropic drugs. Particular.emphasis has been centered on the structure activity relationships among a class of compounds of immediate interest to TSD/CB.The scope of the program includes studies on the distribution and metabolic fate of selected compounds having siginificant central nervous system activity. Studies also will be conducted on the pharmacological aspccts of drug tolerance and addiction together with an examination of the metabolism of drugs acting in the central nervous system. It is expected that results obtained will provide information required for devclopment of more effective compounds.

46-g0

DRAFT 24 October 1961

MEMORANDUM FOR: THE RECORD

SUBJECT

: Supplement to Project MKULTRA, Subproject 46

[PAGE 27]
2, The additional funds required for this program for the

year amount to \$20, 000.00. To this sum must be added \$800.00 representing a fourper cent service charge to the

who act as cut out, making the total amount \$20, 800. 00. Charges should be made against Allotment 2125-1390-3902. R

has requested that the investigator submit to them a summary accounting on an annual basis of all monies Also, it has been requested\_that any unexreceived from pended funds be returned at the close of the grant year.

4. The requirement for a six months informal accounting on the part of the principal investigator is waived.

5." It'is not anticipated that any permanent equipment will be required for this program.

6. It has been mutually agrced that travel expenses which are reimbursable by the University from project funds will be accounted for in a manner consistent with the accepted policy. of

the University. 7. Dr. possesses Agency TOP SECRET approval.

46.20

2

[PAGE 29]
Receipt is hereby acknowledged of the following checks:

Cashier's Check , dated September 12, 1960, in.the amount of \$7,500. 00, drawo on E payable to Cashier's Check dated September 12. 1960. in the amount of \$300 00 drawn on payable to B Date:00

RECEIPT

[PAGE 30]
25 August 1960

MEMORANDUM FOR: CHIEF. FINANCE DIVISION

: TSD/Budget Officer

SUBJECT

: MKULTRA, Subproject 46, Involce No. 9 Allotment 1525-1009-1902

1. Involce No. \_9 In the\_amount of \$7, 800.00 covering the above subproject is attached.Payment ahould be made as follows:

Cashier'g check ln the amount of \$7,500.00, drawa on a bank,

Cashier'e chack in tho amount of \$300, 00,: drawn on oank.

The cheste shouid bo made payable to

2. Please forward tho checks to Chlef,\_TSD/Research Branch through TSD/Budget Officer by 9 September 1960.

3. Thls is a fioal lnvolce. However, since it is anticlpated that additlonal funds will be obligated for this project the flles should Bot bg closed.

Chief TSD/Reaearch Branch-

Invoice & Certifications

Distributlon: Orig. & 2 - Addressee-1-TSD/FASS 2- TSD/CB

I'CERTIFY THAT FUNDS ARE AVAILABLE 3O AG OMISATION LEERCE NO CHARGE 10 L0NN 1185-109.1902

SESRET

46-32

[PAGE 31]
For sorvices

CERTIFICATIONS

(1) It is hereby certified that thie is Involce No. 9 applying to Subproject 46 of MKULTRA, that performance is satisfactory, that eervices are bcing accomplished in accordance with mutual agree. menta, that a detailed agenda of the payinonts and receipts is on file in TSD/RB, that this bill is juat and correct aad that payment therool has not yet been made.

Chief, TSD/Research Branch

Date:

(2) It is hereby cortifled that this lnvoice applles to Subproject 46 of MKULTRA which was duly approved, and that tho project ie being carrled out in accordance with the memorandum dated 13 April 1953 from the DCI to the DD/A, and the extenaion of this authorlty in eubsequent memoranda.

3 0 AUG 1960

Dato:\_

INVOICE

\$7,800.00

Rescarch Director

[PAGE 33]
O

96-2y

No. 956

Cost Account1505=1004-1102

Object Class-

[PAGE 34]
MEMORANDUM FOR: COMPTHOLLER

ATTENTION

: Fioance Division

SUBJEGT

: MKULTRA, Subproject 46, Additional Authorizatlon No. 7

Uader the autherlty granted la the Memorandumn dated 13 Aprll 1953 frgm tho DCI to the DD/A, and the extenslon of thls authority In subsequent memoranda, Subproject 46 has been approyed and \$7,800.00 of the over-all Project MKULTRA funds bave boea obligated to cover the aubproject's expenses and should be charged to Allotmeat 1525-l009- 1902.

APPROVED FOR OBL OF FUNDS:

Reseatch Director Aし 1960

Date:\_

I CERTIFY THAT FUNDS ARE AVAILARLE AIGATION BERCRENCE CHARCE 1O ALLOTMENT NO. AUTHORIZING OFFICER

Distributlon: Orig. & 2 ÷ Addreasee

1-TSD/OC Y-TSD/FASS 2-TSD/RB

STOREE

46-25

3 August 1960

[PAGE 35]
: Supplement to Project MKULTRA, Subproject 46. SUBJECT

for the support of an expanded research program being carried out by at the University College of Medicine.
Dr.
Acquisition of a difficult to obtain intermediatę of a psychotropic drug
of Agency interest makes possible the introduction of a radio labeled
group which will permit a eignificant study on its metabolic fate. The
results obtained will provide information basic to an underatanding of its pharmacological effect.

2. The additional funds required for this expansion of the pro gram during the remainder of the year amounts to \$7,500. 00. To this sum muet be added \$300.00 representing a 4% service charge to who act as.cut out, making the total amount \$7, 800.00.Charges should be made against Allotment 1525-1009-1902.

has requested that the iavestigator 3. submit to them'a summary accounting on an annual basis of all monies received fror Any unexpended funds will be returned by the grantee at the close of the grant year.

LA

46-H6

DRAFT 3 August 1960

MEMORANDUM FOR: THE RECORD

[PAGE 36]
4. The requirement for a six (6) month informal accounting on

the part of the principal investigator is waived.

5. It is not anticipated that any permanent equipment will be

required for this program.

6. It has been mutually agreed that travel expeoses which are

reimburaable by the University from the project funds will be accounted

for in a manner consistent with the accepted policy of the\_University.

7. Dr. posseases Agency Top Secret approval. The

project is unclassified after it leaves

APPROVED FOR OBLIGATION-OF. FUNDS:

81/60

Distribution: Original only

46-26

[PAGE 37]
RECEIPT

Receipt is hereby acknowledged of the following two checks:

46.97

[PAGE 38]
31 March 1960

MEMORANDUM FOR: CHIEF, FINANCE DIVISION

: TSD/Budget Officer

SUBJECT

: MKULTRA, Subproject 46, Involce 8, A11otmeat 0325-1009-4902

1. Invoice 88 In the amount of \$15, 600, 00 covering the above subproject 1s attached. However, due to refunde of \$1,487.50 from othez projects (as per attachmente) payment should bo tmade as followe:

Casbler's check in the amount of \$13, 512. 50, drawn on a baak.

Cashier'a check ln the amount of \$600. 00, drawa on a lebank.

The checks should be made payable to the

2. Pleage forward the checks to Chlef, TSD/Chemical Branch through TSD/Budget Offleer by 14 Aprll 1960.

3. This is a final lnvolce. Howevor, elnce it is anticipated that additional fonds will be obligated for thie project the filea should not the.cloaed.

C CHECA N THE AMOUNT DF SASSO RECEIVED. 261

Chlef TSD/Chemical Branch

Attachmeote: Involce & Certificatloas

LÉESEEY TPAT FUNDS  AVALANLE

Dlatributions: Qrlg à 2 - Addrossce A- TSD/FASS 2- TSD/CB

GATON SHN592

CHECKIN THS AMOUNT OF \$6 2 RECEIVED. 26ABR

46-28

[PAGE 40]
CERTIFICATIONS

(1) It is horeby certified that thls is Involce § 8 applying to Subprojoct 46 of MKULTRA, that performance is satiafactory. tbat services are belng accompllshed in accordance with mutual agreeinenta, that a dotailed agcada of the payments aud receipts is on flle la TSD/CB, that this bill is juat and correct and that payment thereof has not yet been made.

Chief, TSD/Chemical Branch

Date:

(2) It is hereby certified that this lnvoice applies to Subproject 46 of MKULTRA vhich was duly approved, and that the project ls belng carried out in accordance with the memorandum dated 13 April 1953 from the DCI to the DD/A, and the extension of this authority in subsequent memoranda.

INVOICE

Reaearch Director

[PAGE 41]
CERTIFICATION

(3) It is heroby certlfiod that under subproject 22 at the cloga of FY 1960 a balance of \$1,487.50 representing unused funds remalned in Subproject 22 which is still contlnulng. Thorefore lt ia requeated that \$1, 487.50 of Invoico No. 8 be credited subproject 46 as a return of uaused funds FY 0525-1009-4902, MOR 1909.

gegm

[PAGE 42]
No.1909
Cost Account 0535: 109- 4912

Object Class

D

SEORE

[PAGE 43]
MEMORANDUM FOR: COMPTROLLER

1 Finance Divislon ATTENTION

SUBJECT

: MKULTRA, Sabproject 46, Additlonal Authorization No. 6

Under tho authority granted in the Memorandur dated

13 April 1953 from the DCI to the DD/A, and the oxtensioa of

thie aathority in gubsequent mersoracda, Subproject 46 has been

\*pproved and \$15, 600. 00 of tho over-all Projoct MKULTRA fanda

have beon obligated to cover the subproject's expensos and should

be charged to Allotment\_0525-1009-4902.

APPROVED FOR OBLIGATION OF FUNDS:

É CARTIPY THAT FUNDS ANE AVALASL QUGATON

Date:

Distributlon: Orig & 2 - Addrestee

2- TSD/CB

46.30

15 March 1960

[PAGE 44]
DRAFT 15 March 1960

MEMORANDUM FOR: THE RECORD SUBJECT : Supplement to Project MKULTRA, Subproject 46

1. The purpose of this supplement is to proviae aaaitionai runas for the support of a research program being carried out by D and associates at the Univereity College of Medicine, The program provides fundamental information and elucidates the mechaniem of action of certain psychotropic drugs. Particular emphasis has been-centered on the strücture activity relationships among a class of compounds of immediate interest to TSD/CB. The scope-of the program includes studies on the distribution\_ and metabolic fate of selected compounds having significant central nervous system activity. It is expected that results obtained will provide information required for productive research into the pharmacodynamics of more effective compounds.

2. The additional funds required for this program for the year amount to \$15, 000, 00.. To thia sun must be added \$600.00 representing a four per cent service charge to who act as cut out, making the total amount \$15, 600,00. Charges should be made agaiost Allotment 0525-1009-4902.

3. has requested that the investigator eubmit to them a apmary accounting onan annual basis pf all monies received from Also, it has been requested that any unexpended funds

46-30

[PAGE 45]
be returned at the close of the grant year.

4. The requirement for a six months informal accounting on the part of the principal inveatigator is waived.

5. It ie not anticipated that any permanent equipment will be required for this program.

6. It has been mutually agreed that travel expenses which are

reimbursable by the University from project funds will be:accounted

for in a manner consistent with the accepted policy of the University.

7. Dr Dossesses Agency TOP SECRET approval. The

project is unclagsified after it leaves 1

Date:

Distribution: Original only.

A

46-30

[PAGE 46]
27 Janusry 1960

MEMORANDUM FOR: THE RECORD

SUBJECT:Actionon MKULTRA Audit.Excepsions-TSS/GD

Financisl statement for the grant from
for expenditures-from-9/53-to-3/53 habeen approved.
tion of the principal-investigator will be obtained whon tho
grantee is visited by TSs/CD\_personnel.to discuss research progress and future prograniing. Sunmary accounting for funds. received through 9/30/59 has been approved and cortified by principal investigator.

Chief TSS/Chemical Division

46-31

[PAGE 48]
RECEIPT

Receipt is hereby acknowledged of the following two checka:

dated 3 September 1959, drawn
T in the amount of
\$46.640.00. payable B

Official Chack dated 3 Septernber 1959, drawn on the amount of \$1, 865.60, paya

DATE 10 SPt59

[PAGE 49]
No./2

Cost Account9 250275-902

Object Class

SECRITE

[PAGE 50]
HEMRANUM FORT COPTROLLER

ATTEITICH 1 Firance Divlsion

SUJECT 1 MOLTaA SubproJeot h6, Authorization No. 5

Under the authority graated in tho teacrendus dated 13 bpr11 1953 froa the DOI to tho DD/A and to extension of this euthority in subeeqvent meoorrvie, Subprojoct 46 waa provlovely epproved. Under the sane euthority an addittonel sua of \$43,505.60 bes been authorized to cover the aobproject's expenses.ihis expendltuure should be charged against Allotoent 9-2502-15-903.

Distribution Orig & 2 - Addrossce 1 -TSS/0C 1-TSS/FASB 1 - TSS/SRB 2-TSS/CD

22 Acguat 1958

[PAGE 52]
21 Auguet 1959

MEMORANDUM FOR: CHIEF. FINANCE DIVISION

: TSS/Budget Officer

SUBJECT

t MKULTRA, Subproject46, Iavolce No. 7 Allotment.9-2502-75-902:

1. Invoico No. 7 covering the above eubproject is attached. Paymont hoold be made as follows:

Caahler's check.la.the amount of \$46, 640. 00,
drawn on a baok. E

Casbler'e check In tho amount of \$1, 865. 60, drawn on a bank. a

The checksahould be made payable to

2. Please forward the check to Chief, TSS/Chemical Divlslon, through TSS Budget Officer, no later than 3 Septembor 1959.

3. Thls ip a final lnvolce. However, slnce it ls anticipated that additlonal funde will be obligated for thie project the files ehould not be clased.

46-37

[PAGE 53]
CERTIFICATIONS

(1) It la hereby certified that this is Invoice No. 7 applying to Subproject 46 of MKULTRA, that performance is satiafactory, that services are being accomplished in accordance with mutual agreements, that a detailed agenda of the paymente and receipts is on file in TSS/CD, that this bill ie just and correct and that payment thereof has not yet been mado.

Date:

Chief, TSS/Chemical Division

(2) It ig hereby certified tbat this invoice appliee to Subproject 46 of MKULTRA which was duly approved, aod that the project ie being carrled out in accordance with the memorandum dated 13 April 1953 from the DCI to the DD/A, and the extension of thls aùthority in aubsequent memoranda.

Research Dircctor

46.37

\$48,505.60

[PAGE 54]
11

[PAGE 55]
PROPOSED ANNUAL BUDGETS FOR NEXT TWO YEARS, 9/58-9/60

I have examined and approved thg euhaittod expenditures.

12

46.38

Dat15dupt58

[PAGE 56]
RECEIPT

[PAGE 59]
MEMORANDUM FOR: CHIEE. FINANCE DIVISION A VIA:

SUBJEC T -MKULTRA Subprolect 46, Involce 6, 11otment 7-2502-19-001 I. Involce No.grid attached covering tha above subproject.
Payment should be made as followra
ww ahier's check In the amount of \$2,387.13, drawn on a bank, Cashler's check in the amount of \$39, 81s.S6, drawn on a bank, Cashler s check in the amount of \$19,907.78, drawn on a
All three checks shoalo be made payable to the 2. Please forward the checks to Chlef, TSS/Chemical
Divtston through TSS/Budget Officer by Erlday, 5 July 1957. 3 1s a final Involce, A total of \$93, 121.60 was ob
ligated under this subproject duriag FY 57. However slnce it is
anticipated that additlonal funds will be obligated for this project,
the files should not be closed Acung Chiol TSS/Chemical Diviston

Attachments: Invotce & Certiftcations

Distribution: Orig & 2 = Addressee 1 - Comptroller

D. 887 001236 600.1 2502-10-001 17.9 # 62,110.47 --#62,110.47 Cr. Cash

21 June 1937

[PAGE 61]
For services

CERTIFICATIONS

(1) It Is hereby certified that this 1s Invoice No. 6 applying to MKULTRA Subproject 46, that performance is satisfactory, that the services are being accomplished in accordance with mutual agreements, that a detailed agenda of the payments and receipts is on file in TSS/CD, that this bill is just and correct and that payment thereof has not yet been made.

Acting Chief, TSS/Chemical Divislon

Date:=

(2) It is hereby certified that this invoice appltes to MKULTRA Subproject 46, which was duly approved, and that the project is being carrled out in accordance wlth the memorandum dated 13 April 1953, from the DCI to the DD/A, and the ext ension of this authority in subsequent memoranda.

\$62,110.47

Research Director

[PAGE 63]
Receipt is hereby acknowledged of the following two checks;

dated Decombén.19. 1956, drawn on Cashier's.cheel in the amount of the \$29,816.66

and

Treasucarlsicheck dated December 26, 1956, drawn th the amount of
on th
\$1, 193...

Date: " Jgaunary 97

RECEIPT

[PAGE 64]
13 December 1956

MEMORANDUM FOR: CHIEF, FINANCE DIVISION

VIA:

TSS/Budgot Officer

SUBJECT:

MKULTRA Subproject 46, Involce 5
Allotment 7-3502-10-001

1. Invoice No. 5 is attached covering the above subproject, Payment should be made as follows:

Cashler's check In the amount of \$29, 315.66, drawn on a bank

Cashier's check in the amount of \$1193.87, drawn on a bank.

Both checks should be made payable to

2. The checks should be forwarded to Chief, TSS/Chemical Division, through TSs/Budget Officer, no-later than Monday. 31 December 1956. Other Involces wilt follow.

46-44.

S-1601

[PAGE 65]
INVOICE

CERTIFICATIONS

() It is hereby certified that this is Iavolce 5 applying to MKULTRA Subprolect 46, that performance Is satisfactory, that the services are being accomplished In accordance with mutual agreements, that a detailed agenda of the payinents. and receipts is on file in TSS/CD, that this bill ts just and correct and that payment thereof has not yet been made.

Chiet, TSS/Chemical Divislon

Date:

(2) It is hereby certified that this lnvoice applies to MKULTRA Subproject 46, which was duly approved, and that the project is being carried out in accordance with the memorandum dated 13 April 1953, trom the DCI to the DD/A, and the extension of this authority in subsequent memoranda.

Date:

Research Director

[PAGE 66]
MEMORANDUM FOR: THE RECORD

: Project RA, Subproject 46

1. The purpose of this project is to provide funds for the partial aupport of the research progrem being carried out by and associetes at the Univereity of Bollege of Medicine. Additionel support for th ly being provided hy 00 Tand the University of ror 19y8 thro0gn l960 (including only that por by Agency funda) is attached. The attached report indicates the detaile of the program to bo carried out and also shows current status of the work.

2. As is indicated 1n the atteched Rerort, thie program which is aimed at the elucidátion of the mechanism of action-of ISD-25 hes met with considerable success. Many of the facts and relationships developed in-the preliminary work on methods and techniquee have materially advanced other projects being carried out by TSs/CD. Actually, the successful completion of this project would remove several of the most otstinate "road-blocks" in the\_ccntinued development of the psychochemical field, namely: (1) a speciric antidote for ISD-25, (2) a-sensitive metbod for assaying ISD-25.in blood and urine, (3) a sensitive\_qualitative laboretory screening system for psychochemicals,(4) an idea of the relationship betveen chemical structure and biological activity in this type or material, and (5) the relationship between-ISD-25 and other materials of a similar nature which are now available.

3. The investigator's request for a two-year graut is reasonable in the opinion of TSS/CD. We have previcusly conducted this prograa of basic research-on a tvo-year basis. It should be noted that the present budget for the coming tvo years is approximatelyrof that previously required. This does not represent any deerease in the totsl effort in the progrem. It has been accomplished-by the eddition of furds from other sources. By carefui selection of the sources of additiónal funda TSS/CD has been able to maintain the same control over the gosls of the project as it possessed when it was-the sole support.

vill serve as cutout for the transfer of funds to the investigator. The

DRAFT HWB/vaj 22 August 1958

46-45

[PAGE 67]
estimated cost of the vork 1s \$h6,640,00 for a period of two
years. To this quatbe edded four percent service charge for amounting to \$1,865.60. Therefore, the coat or this progrem for two yers vill not exceed \$h8,505.60.

5. The University of shall retáin title to any perwanent equipment in lieu ernigner overbead rates.

requeeted that the investigator subnit to it a sumcary accounting for all monies received under its grants and that all unexpended funds remaining at the end cf the project te returned to the Pund.

7. It has been mutually egreed that travel expenses which are reimtursable by the University from project funds vill be accounted for in a manner consistent with the accepted policy of the Univeraity.

8. Professor has been cleared to Ton Secret by the Agency end is-the only Witting individual at The project is uncleasified after it leaves\_the

APPROVED POR OBLIGATION OF FUNDS:

Date: 25199

Attachment: Propoaal

Distribution: Original only

2.

46-45

[PAGE 68]
l.· The purpose of this project is to provide funds for the partial support of the research program being carried out by Prof. and associates at the University of College of Medicine, Additional supnort forthe, progran. ts currently being pro vided by and 'the University of ine proposal covering the details'of the program and the budgets for 1956-57 and 1957-58 (ineluding-only that portion covered by Agency funds) is attached.

2. As is indicated in the attached proposat, this program which is aimed at the elucidation of the mechanism of action of LSD-25 has met with considerable success. Many of the facts and relationships develcped in the preliminary work on methods and techniques have materially advanced other projects being carried out by TSS/CD. Actually, the successful completion of this projeet would remove several of the most obstinate "road-blocks" in thé continued development of the psychochemical field, namely: (1) a specific antidote for LSD-25, (2) a.sensitive method for assaying LSD-25 in blood and urine, (3) a sensitive qualitative laboratoryscreening system for psychochemicals and (4) an idea of the relationship between chemical structure and biological activity in this type of material.(s) ---

3. The investigator's request-for a two year grant is reasonable in the opinion of the writer, During the past year two very acceptable candidates for the post of enaymologist on this program have turned the job down because of the year-to-year basis of tne program. It appears that it would not be feasible to achieve the same end by increasing the support from sources other than tho since the goals of the program would have to be attered considerably to mnake this possible.

4. will serve as cutout for the transfer of funds to the investigator. The. estimated cost of the work is \$89, 540.00 for a period of two years. V
46,640.00

46-46

5 December 1956

MEMORANDUM FOR::THE RECORD

SUBJECT:

Project MKULTRA, Subproject 46

[PAGE 69]
To this must be added four percent service charge for ther
, amounting to \$3, 581.60: Therefore, the total cost orthis pro
gram for two years will not eyeerd \$93 121.60. 48,505,60

shall retain title to any per-5. The University o] manent equipment in lieu or mgner overhead rates.

has requested that the investigator submi: to it a summary accounting for all monies received under its grants and that all unexpended funds remaining at the end of the project be returned to

7. It has been mutually agreed thattravel expenses which are reimbursable by the University from project funds will be accounted for in a manner congistent-with-the-accepted.policy of the University.

8. Proi. tas been cleared to Ton Secret by the Agency and is the only witting individual a the project is unclassified after-it-leaves the

Chiei, Branch II TSS/Chemical Division

Approved:

hby Gottl Sidney Gottiieb

Chief TSS/Chemical Division

Attachment: Proposal

APPROVED FOR OBLIGATION OE FUNDS:

eResearch Director

Oate:

Distribution: Original only

[PAGE 70]
46-46

Proposal for the Continued Study of the Metabolism of d-Lysergic Acid Diethylamid

It is proposed to continue the study of LSD-25 and related compounds in substantially the same areas of work as during the past year with alterations as required by the advances made. The program has now progressed to the point where practical plans for thę work can be laid down based upon knowledge and experience gained in the past. Very briefly stated the present status of the work is as follows;

1. We have shown that side-chain carbon labelled LSD-25 remains intact during its passage-through-the animal and thus that it is an adequate tracer molecule.

2. We have completed organ and tissue distribution studies from the 10 minute to the 12 hour period with the available Carbonlabelled tracer.

3. We have found that two.species\_of mammnals other than rats show the same pattern.of.l.SD-25 distribution after dose indicating that an extrapolation to\_man\_is\_probably feasible.

4. We have isolated and partially characterized the metabolites of LSD-25 exereted by the liver and -we-are in the process of producing amounts\_of these\_ sufficient for further work.

5. We have devetoped a technique of meastrement of cortical electrical potentials which allows-us to study the effects of. LSD-25 and various inhibiting materials directly in the central nervous system.

6. 'We have also developed a biological assay technique using a spinal reflex arc of the cat which is particularly arienable to inhibition and potentiation"analysis" studies with LSD-25 and related compounds.

7. We have investigated tie known synthetic methods for the production of LSD-25 including biosynthesis from the point of view.of the production of radio-carbon ring-labelled material. None of these so far has proved a feasible approach.

[PAGE 71]
We have made considerable progress toward a new and com-8. pletely difforent synthetic process for LSD-25 which if it proves successful will provide the ring-labelled LSD-25 that is needed for more definitive tracer studies.

We have completed an exhaustive study of tissue extraction 9. techniques working toward a method which will allow the chemical isolation of LSD-25 from body fluids and tissues when it is present in the usual concentrations. The method at present under\_ investigation shows good promise of achieving this goal as further refinements are introduced.

It is apparent from the above accomplishments that the major progress to date has had to do with developing thə tools for pursuit of the main goal of this research program. It is also apparent that-with a few additions to these methods;-we are now in a position to make use of what we have learned so far to produce basie information about the sites and mode of action of LSD-25, how this action can be modified or reversed, how-it might be accentuated, what other materials might produce comparable or complimentary,effects, how such materials can be\_detected in the medico-legal sense, and possibly considerable basic information on the neurocnemical basis for the stress reaction and other important responses of animals to their immediate environment.

It is the opinion of those familiar with the details of this project that the next two years work will provide many if not ali of the desired data indicated above. As in every case of à program of this type, a number of unforeseen difficulties as well as some fortuitous discoveries will no doubt appear as-the work progresses, however there is every reason to believe that the rext two years will yield directly useful information at a rate far above that of the introductory period of the program.

In the past this rescarch program has been carried out on a year-to-year basis. There were several reasons for this, chief arnong which was the fact that the feasibility of our general approacn to the problem had not been completely established. Contributing factors were that varying amounts of support were av-iiable from sources other than I and that catside pressure on the project personnel to take positions in longer term projects elsewhere was not greatenough to cause them to leave. All of those factors now appear to have changed in such a way as to roake it

46-46

2

[PAGE 72]
advisable to place the program on at least a two year basis as shown in the firancial proposal, We have indicated in the foregoing resume of the work that the feasibility of our approach to the problem has been amply demonstrated. In addition, the University of as assumed a long term obligation to this Department to provruenew integrated working space for the program,-more basic equipment and certain faculty status changes for those employed on the program. The obligation assumed by the University cannot be readily stated in financial terms since it involves many intangible advantages to the program. Finally, it is becoming impossible to retain competent personnel on the basis of oné year appointments and so we find it almost mandatory that we obtain commitment for at least two years' support.· We have in the past solicited as much outside support for the program as time\_would\_allow and we shall continue to do so in the futuce, howeyer the basic framework of the program depends upon support.

As it is planned at present, the project personnel will remain the same for the next two years except for the addition of an enzyologist and.one technictan if they can be obtained. Professor f the Chemistry Department has indicated his desire tatn the synthetic chemical work and the various other consultants to tha program will continue to serve. Due to the suprio , and the University of of the the cost of new oersonnel can be absorbed without any major increase in th Trant.

46-46

O

3

[PAGE 73]
46-47

10155 4
40700

[PAGE 74]
MEMORANDUM FORI COMPTROLLER

ATTENTION:

Flaance Division

SUBJECT

MKULTRA Subproject 46, Additional Authorization No. 4

1. Under the authority granted in the memorandum dated 13 April t953 from the DCI to the DD/A and the extension of thts authorlty in subaequent memoranda, Subproject 46 was previously approved. Under the same authority an additlonal sum of \$93, 121,60 bas been authorized to cover the subproject's expenses.

2. Thls expenditura should be charged against Allotment 7-2502-10-001.

SIDNEY GOITLIEB Chtef TSS/Chemical Division

APPROVED FOR OBLIGATION

COTRANT AN AVALASIE 1236 CHARS TO 7-250210-01

Research Director

Date:

Distributlon:

Orig & 2 - Addressee

1- TSS/OC

T- TSS/FASB

1- TSS/SRB

2 - TSS/CD

rSs/cDl

S December 1956

[PAGE 75]
D

[PAGE 76]
MEMORANDUM OF ACREEMENT

The purpose of this Memorandun of Agreement is to set forth the mutual administrative responsibilities of the principal research investigator and the sponsor,Therefore, it is mutually agreed that,

A. The piincipal investigator shall submit to the sponsor, at six month intervals, an informal statement of expenditures of monies advanbed for research activities.It is requested that the statement be submitted in essentially the following form:

Personal compensation:(Salaries, Subject fees)

Equipment

Supplies and Services

Contingencies-

Overhead

B. It is understood that any travel expenses incurred-in the furtherance of the research program will be accounted tothe University in a manner consistent with its éstablished practices. and policies.

C. The principal investigator-shall-submit-to the sponsor semi-annual reports on.the technical-progress of the research covered by these funds.

Date: 21 Wale 1956

46-50

[PAGE 77]
RECEIPT

[PAGE 78]
MSMORANDUM TOR: CHTE, FINANCE DIVISION

TSS/Budgot Officer

MULIA Subprojegt 46, Invoice 4
Allotment 6-2502-10-001

1. Invoioa 4 for the above subprojeot ie ettaohed. Paynént should bo made as follovst

Two cashier'e checks, ooe for 8654.72, drawa on a and the second in the anont of \$17.077 28. dran on a pank both payable to

2. The above oheeka should be forvarded to Chief, TSS/Chenical Diviaion, through TSs/Budget Officer, no later than 13 Maroh 1956.

3. This ie a final invoico. A total of \$35,46/.00 vas obligatod under this subprojeot during FY 56. Hovever, sinco it is antioipated that additional FY 56 funds will be obligated for pthig projeot, the files should not be cloeed.

CHECKIN THE AMOUNT OF S6/72
RECEIVED, 1613

Aoting Chief TSS/Chemical Division

I CERTIFY THAT CUNDS ARE AVAILASLEOEUQATION /771016.25010001

Dietributiont Orig & 2 - Addressee 1 - Comptroller

886-603.1-11.17.0. 17732.00120

58671

[PAGE 79]
CERTIPICATIONS

(1) It is heroby certified that thia ia Involce 4 applying to MXJLTRA Subproject 46, that performance ia satiafactory, that the sorvices are being acdomplished in accordance with autual agreemente, that a detailed agenda of the payments end receipto is on filo in TSS/cD, that this bill is just and correct and that payment thoreof bag not yet been made.

Acting Chief, TS3/Chemical Division

DATEI

(2) It is hereby certified that this iuvoice applies to MKULTRA Subproject 46, which was duly approved, and that the project ia being carried out in accordance with the menorandua dated 13 April 1953, froa the DCI to tho DD/A, and tho extenaion of this authority in subsequent mamoranda.

DATE1

Researoh Director

[PAGE 80]
march

17732.00 0.

D

Subproject 46

2/6.53

\$35,464.00

Jan 3, 1956 Inyoice /1

17,732.00

[PAGE 81]
FTLE SUS 46

RECEIPT

I bereby acknowlodge receipt of the following two checks:

Cashier's Check , dated January 12, 1956, -in the anount of \$709.28.

Cashier's Check dated January 12, 1956, in the amount of \$17,022.72.

Both checka are drawm on

, and are made payable tot

Dato: tacra, 24, 1956

[PAGE 82]
NOMORANDUK FOR CHIIF, FINASCE DIVISION

TSS/Budgot Officer

\- MULTA Sabproject 46, Iavoico d Allotpent 6-2502-10-001

1. Invotce f1 is attached covering tha atove sutproject. Other invoices will follov later. Payoont ahould bo made as followet

Two cashier'a obeoka. mavable t 28 the eroant of \$17,022.72, both
drevn on d Lanx.

2. Both chocke chould te forvardod to Chier, Tss/Cheaical Division, through Tss/boiget Orficer, no later than 13 Jozuary 1956.

SIDNY GOTTLDB Caief TSE/Qeaical-Division :

Attachaentat Invoice & Cortifioationa

177 6.3502-10.001 19.

4655

3 Jemary 1956

[PAGE 83]
CERTIPICATIOSS

(1) It is horeby certified that this is Levoleo #3 applying to Cobproject 46 of MUlsRa, that perforenco im satiafaotory, that the servicos are being ececplished in accordance vith putuel mareasonte, that a detailod asenda of the parosnta and reoeipte is on file in Tss/co, that this bill is fuat and correct and that paymont tharoor haa not yot boan nede,

GINA

Catef, Tss/Chenical Divieion

46 of Nulisa vhich vas duly approved, and that the projoot is being carried out in acoordance vith ths peoorandsa datod 13 April 1953 froa tho Dol to tho D0/á, ant the ertanclon of this puthority ia subeoquant poeorenda.

[PAGE 84]
MORANDUM FOR:COHPTROLLIR

ATTINTION:

Finance Division

SUAJECT

MlmA Bubproject 46, Adlitional Authorisation No. 3

Gnõer the authority granted in tho nemoraniue dated 13 ápril 1953 froa the DOI to the DD/A, and the axtension of this muthority in mubsequent saoranda, Subprojeot 46 vas previoualy epprovod. Uoder the saae authority as additional gue of 835,464.00 han bern suthorised to cover the subprojoct'e expensse, (thereby bringing to a total or \$56,240.00 funde obligatod doring PY 56) to be eharged to A110taant 6-2502-10-001.

SIDKEY GOTTLUES Chief TSS/Cheaical Divisica

APTROVED EASLIGATICH OF FUNSI

Besearch Director

Dater

Dietribationt Orig & 2 . Addressce

19 Decombor 1955

[PAGE 85]
: Extension of MKULTRA, Subproject 46

1. Thé scope of this research program is intended to tó be done with ISD and related compounds by Professor University for a period of one year at (ctobe1 0 September. 1956,The preakt 11 be handled for cutout through Professo and coyerpur

2. The general\_objectives-of this project are\_directed at the elucidation of the site and mechanisn of action of ISD by use of isotopically tagged molecules, the establishment of adequate methods for isolating ISD end its metabolites from biological materials, and a method for identifying these compounds.

has available to him at a 3. Professor highly competent group or scientists of international reputation encompassing thefields of physical and organic chemistry in eddition to those-of medicine and psychology. He plans to use these reople as inforral consultants-in the work.

4. The costs of\_this.program are estimated to be.\$35,464.00 including \$3, 100.00 for the ten percent University overheed charge \$1.364.00 e.four cercent service charge by Charges should be

5. This project will be completely unclassified after it

APPROVED FOR OBLIGATION OF FUNDS:

Research Director Date: 19 Bee.1955.

TEs/Cnestcal Division

APPROVED:

Attechment: . Proposal

Chief, TSS/Chenical Division

Distribution: Original Only

46-57

MEMORANDUM FOR: THE RECORD

[PAGE 86]
Continued Study of the Metabolism of d-Lysergic Acid Diethylamid

1: Studies of the metabolism of d-lysergic acid diethylanid (LSD) are complicated by the fact that the effective doses are in nicrogram quantities. Tagging the molecule with radioactive or with stable isotopes therefore assumes an extraordinary importance since\_only by this means is there any likelihood of obtaining information in a relatively\_short time. The over-all plan will be to incorporate into the molecule suitable atoms-to serve as tags and to administer it to experimental animals-in whose. tissues the. tagged atoms can be identified after various time. periods. By combining several methods of tagging, deductions can be made as to the fate of the intact molecule or certain fregment: of it. This approach requires-the coordinated work of a team representing experts from a nunber of fields. We.are fortunate enough to have such a.group of trained individuals representing pharmacology, biochenistry, synthetic organic chenistry, and biophysics.

2. Synthesis of LSD and related compounds. The chemical-nature of the compound makes it a difficult one to work with. Knowledge of- the metabolism of ISD may be gained either by studies-of-this: molecule suitably tagged-or.by studies of lysergic acid or various derivatives in which isotopes have been introduced at proven locations..

3. Several isotopes show promise as possible tags for use in the LSD molecule. Radiocarbon (carbon 14) and tritium (hydrogen 3) are of exceptional interest because these two elements make up a large part of the molecule. Both can be obtained with very high-specific-activity-and-therefore may be able to supply sufficient radioactivity so that microgram quantities can be traced in

46-57

OO

ao

[PAGE 87]
the body.  Heavy nitrogen (nitrogen 15) has many advantages; however, as a ring element, synthesizing it into the molecule will be an exceptionally difficult feat.

4. The synthetic chemical program is under the direction of Dr Lecturer in Chemistry.He will be assisted by Dr. post doctoral fellow in chemistry coming this fall from the University of and by a graduate student to be appointed.

5. Metabolism of ISD and related componnds. The problem is to discover what the body does with LSD. The percentages of -a-dose of-LSD retäined in many other organs and tissues of the-body will be measured. The pattern of excretion is important. Inrornation as to what chemical alterations\_are\_induced by the metabolic activity of cells-in the central nervous system or in the liver or in the muscle will be sought. Because of-the ability of this molecule to produce schizophrenic-like disorganization:in normal humans,the concentration of ISD. in the central nervous systen will of course-have-a-prime interest. One task will be to discover whether concentration differences exist-in various parts of the central nervous system.

6. The over-all budget-is thus-\$34;100.00 plus-the allowance for university overhead.

OO

ao

4657

2

[PAGE 88]
PROPOSEDBUDGET

October 1, 1955 to Septembor 30, 1956.

[PAGE 89]
PROGRAM FOR.SUBPROJECT 46

FISCAL YEAR 1955

[PAGE 90]
OUMULATIVEFINANCIALSTATUS

[PAGE 91]
RECEIPT

46-59

I hereby acknowledge roceipt of the following checks:

Treasurers check Treasurers check Treasurers check Treasurers check in the amount of \$29,803.10, in the amount of \$1,168.12, in the amount of \$23,033.34, in tho amount of \$917.34,

checks drawnon dated 27 September 1955, and payable to

Dato: Gelthe 6 1981

[PAGE 92]
MOKRANDOH FOR: CHINP, FIKANCE DIVISION

TSs/Budget Offieer

SUBJECT

ULRA Subprojoct 46, Invoice f2, A110tmanto5-2502-10-001& 6-2502-10-001

1. Invoice f2 is attached covering the abore eubprofect. This is à final invoioe. It ie requeptod that paymant be nsde as follovsi

To oqsbier'a cheoks drava on a wmtss bank, Dayable one to in tho asount of \$23,033.34 and the se0ond f6r 0917.34.

2. The checks should be forvarded to Chiof, TsS/Chouical Diviaion, through Tss/Budget Officer, no later than 30 Septesber 1955.

3. .The two invoices covering this subprojoct eggregeto \$35,776.00, and make uoe of the talance of tho Pr 55 funds, plus the PI 56 funde obligatod to date under this subprojoot. Since it ia expooted that additional FY 56 funda vill be obligeted uier this subproject, the files on this projeot ahould pot be clopod.

ICERTFY THAT FUNDS ARE AVAILABLE:

16 Septomber 1955

[PAGE 93]
(1) It is hereby gertsrtod that this is Invoico f2 applying to Suborojoot 46 ofKulaRathat porfornance is satisfaotory, that the sorvices gre bet Ang agcompliahed in accordance with mutual agreements datailed agenda of the paymonts and recoipts is on ftl 8g/cd. that this bill is juat and correct end that pays foor hes not yet been nade.

(2) It is hereby certified that this iavolog applios to Subprojoct 46 under MKULTA which vas duly approved and that the project is being oarried out in aocordañce with the mamorandum datod 13 April 1953 from the DCI to the pD/a and the oxtonsion of this authority in subsoquent menorindar

[PAGE 94]
MOARANOUN FORI COOTROLLER

AlTlorloNs Finance Diviston

S08JICT

ULiRA, Sabgoject 46, Acditional Authorisation No. 2

Voder tho authozity granted in the axmorandua dated 13 April 1953 froa Uhe DCI to tho DO/A, and the extanalon of thie authority in subsoquent neaoranda, Subprojoct 46 vae previoualy approved, Uoder the sase authority on ad4itional mu of 820,776.00 bas bosa euthorisod to cover the mtprojeot's expanoes, (thereby bringing to a total of \$20,776,00 fuds obligated during 7r 56) to bo charged to A11otpmnt 6-2502-10-001.

SIDIY GOITLDB Chief TSS/Cheaioal Division

Dater

APFROVED FCR COLIGATIOM OF FUNDS

Distributioui Orig & 2 = Addroaseo

1-TSS/00

J1 - TSS/FASD

Bepcarch Direstor

CERTIFY THAT FUNDS ARE AVALABLE

[PAGE 95]
MEMORANDUM FOR: THE RECORD

SUBJECT : Addendum to Subproject 17 and 46

l. The purpose of this addendum is to set forth the mutual administrative responsibilities of the contractor and sponsor..

The aboye subprojects represent the research program of: Di financed under MKULTRA, covering the period of 22 Cctooer 1933 through 31.October. 1955.

Tas requested the University to nom a sumary accounting of monies recsived from the Also, they requested-the return of any unexpended funds received under a grant from theeg

4.Title-to.any-permanent. equipment purchased by funds granted the University-shall be retained by the Univeraity in lieu of higher overhead rates.

5. It.was wutually agreed that documentation and accounting for travel expenses which are reimoursable by the Universityshall conform with the accepted-practices of that Institution.

6. It was agreed that technical reports reflecting the progress of the research program shall be submitted at mutually acceptable intervals.

SIDNEY GOTTLIES Chief TSS/Chemical Division

Distribution: Orig & 2 - TSS/CD

46-62

28 July 1955

[PAGE 96]
Aub. 46 46-63

I hereby acknowledge receipt of the following:

CHECKIN THE AMOUNT OF SJ RECEIVED.

To
FORM NO- 36-66
MAR 1949

please return aigned copy{les) of this rpcelpt

#46

I hercby certify receipt of Cashier's Check in the

amount of \$11,366.66, drawn on the

Date: Cipis 14 1911

TO:

APR-1 3 1955 DATE

MEMORANDUM RECEIPT

[PAGE 97]
dut. 北6

46-64

I hereby acknowledge receipt of the following:

CHECR IN THE AMOUNT OF \$S6 RECEIVED,

Please returnslgned copylies) of this receipt

-FORMNOL35-66
MAA 1949

Q

CERTIFICATE

I hereby certify receipt of Cashier's-Check
drawn on thé the amount of \$458.66,
payable to

Date: Cipnis 14, 1965

MEMORANDUM RECEIPT

APR 1 4 1955 DATE

[PAGE 98]
MEOKRANDUI FOR: CHE, FINECE DIVISION

Project IxOLiRA, Subproject Bo. 46, Invoice f1, A11otment 5-2502-10-001.

Invoice No. 1 fer Sobprojeot 46 of Projeot HKULRA 1e attaonsd. Othor invoicos vill follov later. It is requeatod that paveont bo pade by tvo canbiare chocks, one fo tho amcunt of 811.366 6nd cne foc c4 (6. pyable to Tho chocha phcald to ocnt to Chiar, Ts/co tuougt T/bodget 0cticer tg Voisesday, 6 Anr11 1955.

SIOMEY GOTTLILD Ghiet TSS/Chesical Divialon

ittachnantsi Invoice à Cartifications

I CERTIFY THAT FUPDS ARE AVAILABLE:

OBLIGATION REFERENCE No.

5.3501-10-01 CHARGE TO ALLOTMELT No. APRENTO

AUTHORIZING OFFICER

[PAGE 99]
CERTIFICATIONS

(1) It ia hereby cortified that this is Invoica Ho. I applying to Suborojeot L6 of Projoct MULTRA. that performance was satisfactory. that the services vere accomplisled in accordance with mutual agreezents. that a detailed agenda of the paymonts end receipte are on file in TSS/CD, that this bill is juat and correct and that payzont thercof has not yet been made.

Dator

SIDNEY GOTTLIEB Chief, TSS/CD

(2) It is bereby certiried that this invoice applies to Subprojeot 46 undor Projeot MKULTRA vhich was duly.approved and that the project is being carried out in accordance vith the momorandua dated 13 Apri1 1953 froa the DCI to the DD/A, and the extension of this authority in subeequent mpnoranda.

[PAGE 100]
Coder the enthority eronted in the Vesorandui datol 13 Apeil 1953 Croa the DC1 to the Do/A, and the ectension of this outhorlty 1a gabsequont sozorands, Subprojoot 46 bas boon ap proved, and \$15,000.00 of tho over-all Project XULIRA fwnds bare tooa obligatod to covor the subproject's expeases and shoold be cherzed to A1lotsent 5-2502-10-001.

APPROVED POR OBLIGATION C70031

SILNEY COTTLIEB Chief 139/Cosnical Diviaion

Diptributioos Crig & 2 - Adárasceo 1-TSS/00 N1 - TSS/PASB 1- TSS/ 2-TSS/CD

[PAGE 101]
MEMORANDUM FOR: THE RECORD

SUBJECT : Project MKULIRA, Subproject.46

1. The scope of this research program is intended to
cover work te berdone vith ISp and related compounds by Miversity for a period
Professor
of one ye
handled through at-out and c

2. The general objectives of this project are directed at the elucidation of the.site and mechanism of action of LSD by use of isotopically-tagged molecules, the establishment of adequate methods for isolating LSD and its metabolites from biological materials, and a method-for identifying these compounds.

3. Professor Ehas available to him at Ka highly competent group of scientists of international reputation encompassing the fields of physical and organic chemistry in addition to those of medicine and psychology. He plans to use these people as informal consultants in the work.

4. The funds forthis project-include \$10,500.00 for the synthetic tagged LSD, \$20,773.00 for metaoolic-studies.on such compounds,\$3,127.00for-the 10%University overhead charge \$1.376.00 for-4% service charge by Therefore, the total cost for will not exceed-\$35,776.00 for a period of one year. At the time, the sum of \$15,000.00, repread University, plus \$600.00 fee to being committed.The balance of the totat wi at a later-date.

APPROVED FOR- OBLIGATION OF FUNDS:

TSS, Chemical Division

Attachmènt: Proposal

[PAGE 102]
APPROVED FOR ADDITIONAL APFROPRIATION OF \$2O,776.OO:

46-67

[PAGE 103]
46.67

1. Ketabolisu, Dr his intends to undertake graduaje work on the metabolism of certain drugs in the-liver,-using a-liver porfusion technic. is' just startirg this work and has an interest in examining lysergio acid derivatives.

A.Part-time-technician-for-help-with-carbon countn: isnecded. 2. Counters and biophysios end consultant, Dr. Part time. 3.Heuropharnaçology, Dr. time; Mr part tine; a graduate student --Miss 4. Isotope Biochemistry consultant,-Dr ipart time. 5. Synthetio Organic Chenistry, under the general direotion of Dr. pert tine; Dr, graduate student in the Chemistry Department.\_\_ C 6. Clinioal Consultant, Dr 7. Coordinator, Dr The duties of cur part tine nouropharvacologist Dr. left to join the staff of the are being taken over by Dr, instructor in pharnacology. Tho part-tine services of our bicphysicist, Dr who is temporarily at the University in are being taken over by Dr. instruotor in biophysios.

[PAGE 106]
ádliticanl Perfel Motaat severod gaug55 6.3507.10001 20.77600 190e25530bp156 6-2502-10-001 3546400 9 o k 36 1o yrs 7-1502-4.101 93121.60 asay1452ye 9-2.502159248505.60 uplene 0525-7009-4902 15.600.00 1525-1009-1902\$7800,00 lip. 0185-1550-3962822,800100

Iareic? To Pata Alse 1 9//55 1182532 317.4.68 29/6/552395068 3/3/56 1773200 17732.00 3/1/56 17232.00 5710 5693.121.60 93.1211 513eest 31,1010.39 6211647 6 11 une 62110.47 48,505.60 21 Cugist 48502160 15.600.60
8 31mr60 15 600.00 9 15 aveg. "60. 7Y0000
14720,00.00 6