[PAGE 1]
(5)③)

mut tthune? tri2s siery

On checking my files I find that we have some information on oral administration of L-3-Hydroxy-N-phenethylmorphinan. Data indicate that the effects of the drug are erratic when given orally. as contrasted to being very consistent when given subcutanecusly. It has been given in doses ranging between 0.5 to 5.0 mg (total) to adult male postaddicts. Definite morphine-like effects were observed in some individuals at every dose level. These ranged from extremely mild to very intense. Onset of action was also erratic, appearing from one hour to (as long as twelve,

I fear this indicates that the drug is erraticaliy absorbed. This may have some connection with its limited solubility. Although I will check, I now feel that it is probably nct as promising an agent as l-dromoran.

Very sincerely yours,

A-234

IN REPLYING AGOAESS THE NATIONAL IHSTITUTE OF MENTAL HEALTA GIOR R CENR U.S. PVOLIC HEALTH SERYICE HOSPTAL P. O. Bar 1000 LEIINGTON, KENTUCKT

24 August 1956

HANC onn

Harris Isbell, M.D. Director

HI:rn