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MKULTRA

Subproject 17

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Diethylamid.

Stulies of the metabolian of d-lysergio aoid diethylasid (LSD) are coaplidated by the faot that the affective doses are ia nicogram quaatitiee. Tagging the nolecule with redioaotive or with stable isotopee therefore assunes an extraerdiaary inportance since only by this means 1e there any likelihood of obtaining inforation in a relatively short time. The over-all plan vill be to inoorperete into the moleoule auitable atcms to gerve as tags and to adainiater it to exparimental aninale in whoce tissues the tagged atone can be identified efter various tivs ceriode. By coabining several methode of tacgirg, dedcotiene can be made as to the fate of the latact moladule or certain fraenente of it. This approach requiree the coordinated vork of a tepm rapresentins expertt from a nusber of fielde. Wa are fortunate enough to have much a group of trained individuala representind pharnacolory, biocheniatry,\_synthetie organie chenistry. and biophysice. The individuele will be nazed in tho rections belov in which the adtivitiee of the firet year of the progran are desoribad in broad terne.

Syathesis of LsD and rslated conpounds. The cheaical nature of the compound makee it a difficult one to vork with.: Kiowlede of the metabolies of LsD may be gained either by etudies of thia moleculé suitably taczed or by studias of lysergic ecid or various derivatives in. which. isotopes have been introduced at proven locationa. Since the struoture

17-2

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of lyeergio acid has not yet been completely eetabliahed work will be carried forvard nimultaneously on the preparation of tagged molecules and on the total eynthesie.

Several isotopes ahow promise aa possible tage for use in the LSD molecnle. Radiocarbon (carbon l4) and tritium (hydrogen 3) are of exceptional interest becauee thers two elements make up a large part of the nolecule. Both can be obtalned with very hlgh specific aotivity and thorefore may be able to supply guffiolont radioaotivity so that microeTan quantities can be traced in the body. Heavy nitrogen (nitrogen l5) has many advantagee bovever. as a ring element, syntheeising it into the molecule will be an exceptionally dificult feat

The synthetic chemical prograa is under the direotion of Dr.

in Chemistry. He vill be assisted by Dr. in chemiatry coning  frcu a tand by a craduate student to be appointed.

The budget for the eynthetic program,totalg \$7000 and is divided as followe: Sarary for amm, \$4500; etipend for graduate atudent, \$1500; expenses, \$1000.

Metabolisa of LSD and related compounds. The problen is to diacover what the body does with LSD. The percentages of a dose of LSD retained in many other organs and tiasues of the body viil be neaeured. The pattern of excretion in inportant. Information as to what chemical alteratione are induced by the\_metabolic activity oflcells in the central

Fage 2.

[PAGE 4]
nervous system or in the liver or in the rusole will be sought.:.Beceude it is poseible that the olinically aotive fora is not the molecule that is adniniatered, b search will be made for fraguents of. the mclecule and then if possible a braic body of informetion will be developed about the matabolian of lysergic acid. perhape by chemical etudiee-of related molsculea Microtechniques such a raper chromatograrhy may prove to be iaportant. The uge of hietological raiioantographe shoull be inveetitated. Bacmuse of the ability of thie golecule\_to produce achizophrenig-like disorganisation in normal humans, the concentration of LsD in the central nervoue syeted will of course have a yrine interost.\_ Oae task will be to discover whether concentration differences exist in various parts of the ceatral nervous ayeten..

The netabolio progren vill be carried out by.Dr. in pharnocology. Dr.4
of Fheraecoloey, will be available gs to bring to the problem hia
broad training and mexperience in the pharecology of the central
and peripheral nervous system.Dr.
of Biophysics (Pharmacology), whe has been active in tracer research here is to aeoiat vith the biophysical parte of the investi-
Fation: this may involve epecial counters for tritiun and for carbon l4. The total budget for the metaboliom progran is \$i8,500 and 1s
allotted as followe: Slaries. \$5500\$3000.
\$c00; apperatua, \$5000: expenaed, S2000; travel. 5500;
contiagency, \$2000. V

The over-all budget ie thus \$23,500 lus the allowance for

university overhead.

PegoJ.

[PAGE 5]
2y 1955

MEMRANOUM FORI THE RECOED

SUBJECT : Addeodtum to Subproject 17 and 46

L. The purpose of this addoodua is to set forth the mutual adainistratire responaibilities of ths contractor and sponsor.

2. The above subprojects reprecent the ressarch prograx C - of Dr.  financed undar MULIRA, covaring the poriod of 22 October 1953 through 31 Cotober 1955.

B 3. has rocusstedthe Ouiversity to mubit to them a sumary accounting of zocies received from the Muud. Also, they requestod the retura of any unexpended Sunds received under a grant fron the Pmd.

4. Title to any permanent equipment purchasod by Nunda grantai the University shall be retained by:the tniversity in liou of bighor overhead rates.

5. It vas mutually agroed that documentation and accounting for travel expensos which are reinburmable by the University ahall confor with the accepted practices of that Institution.

6. It was agrood that toohnical reports raflecting the progress of the research program ahall be subaitted at mutually acceptable intervals.

SIDBEY GOTTLIEB Chiaf TSS/Chonical Diviaion

APPROVED:

A -  Caier, TSS

Distribution: Or.g & 2 -TSS/CD

[PAGE 6]
MEMORANDUM FOR: THE RECORD

書 Extension of Time for Frojoct MKULTRA, Subproject 17

Subprojeot 17 expires on 31 October 1954. As the

work has not yet been completed, an extension of one

year is heroby suthorized, At the present time no

additional fuds are required..

APPROVED:

Original Coly

77-4

DRAFT

31 October 1954

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March 31, 1954

This is-to certify that I have today received Cashier's check No. M139447 E in the amounc of \$748.00.

March 31, 1954-

This is to certify that I have today received Cashier's.check No.M139442 -E in the amount of \$i8,700.00.

[PAGE 8]
Bunu 2
selperect 17

I hereby acknowledge receipt of the following:

4139147 CHECK#ANTHE AMCUNT OF\$ RECEIVED.

plsase roturn

10 FORM NO. 38-66 MAR 1949

\_signed copylies)-of-this recelpt

SIGNATURE OF RECIPIENT 31 Mrch DATE RECEIVED

MAR 3 1 1954 DATE

MEMORANDUM RECEI

77-6

TU:

FROM:

SUBJECT:

[PAGE 9]
MIIKRASDIN FOR: CEXIEY, FIAAPCE DIVISION

C VIAI

TSS/Budget CfTiosr

SURRCT

Subprojeat 17, Projeot A, Dnvoice \$ 2, Alictaent 4-2502-10

1. Iavoice  2 for Sabproject 17 of Project HuLA 1s atteshed. This invoice ia tbe final aoe to be subaitted wier Subprojoot 17 and vhan paid, conatitutes ccaplete poyment of thia proleas. It io raquosted that poyment de malo by tvo cashier'n checks rule out to the ordar of audtá in the amounts o5. 18,700.00 eod \$748.00. .The chocke shoul4 be. 9ent to Chief. TS3/cD through TGo/audget Ofricer by 1 Apri1 1954.

2. The two iavoices coverins this Subproject aggregate \$29, 172.00 eni rroresent the totol expeniitnre to bo mode umier this Suboro'oct. It is rejested, thereforw, thot.files ca this Subprojeot de clcoed.

Attcchoeats: Invoice  2 - Subproject 17 Certificatione

A /:(19 h 1954)

Diatribution: Addressce.Orig.& 2 v/attaohmmnts

Ccaptroller -1

T33/Briget - 1

1131447 1748.00CHECK#NIN THE AMOUNT OF. \$&Z0ORECEIVED.

A- MAR31 1954

19 Meroh 1554

SIDRRI GOTIID Chiot Cheatosl Diviaica, 238

[PAGE 10]
Por sorvices renderod in copnoction vith MKURA Subproject 17.Detaillel brsakloun and receipto on file in TSS/CD.

..........\$19,448.00

-C

Invoice

[PAGE 11]
CERTIPICATIONS

(1) It ie bereby certiried that this 1s Invoice No. 2 epplying to Subprojest 17 of Froject éUzRa, that technical perforponce by \~ C- empaie satiefactory, that thé vork le deins saccaplished in sosordaace vith the satual acreesnt reeckel vith dté, that - C this bill is juat anà correct unt that paymunt thereor has not yot been pade.

(2) "It is hereby certiriei thct this invoice applies to Subproject 17 under Projoet MULTRA vhieh vas duly ayprovei ani that the project is beiag carried out in scooniance vith the DD/P senoranlua to DCI datod 3 April 1953, the DCI meorandum to D0/A dated 13 April 1953, and the DCI mozorantua to the D0/A dated 19 Jue 1953.

Reseerch Director"

(3) "It ia hareby certifiod that the seope d the progrua of Subprojeot 17 of Projoot MatcA hae deen approvod.

[PAGE 12]
Financiel Statenent for the LSD Project () ae of March 2, 1954.

pore veceined 2 goywants since this wos mode A --

[PAGE 13]
TO: TSSPCD

2 Yoveaher 1953 DATE

FROH: Budget/TSS

SUBJECT: TWO Checks

1 I hereby açknowledge receipt of,the following: Check 135382 in the amount of \$9,350.00 and cheok f35383 in the amount of \$37h.00 aade payable to aae pyment for Invbice  1 Subprojoot 17, Pro5eot MKULTRA.

Please raturn signed copy(les} of thls raceipt

To
FORM NO. 36-68
MAR 1943

MEMORANDUM RECEIPT

[PAGE 15]
MCIORASDUM FOSICHTSP, TIAANCE DIVISION

SUSJECT

9一C TSS/Bulget Of1icer -C Iavoioe No. 1, Sutprojeat 17, Project HuLTA

Invoice 3o. 1 for Sudprojoot.17 of Project MraA is attached.

It is requestei that paybent be male by tvo cashier's checke in the amomts o \$9,350.00 and \$374.00 nade cut to 3 The checks abould bo seat to Chier, Ca/ms3 through Ps3/aulcet O2ricer

not latar than 30 Cctober 1953.

ATDMEY COTTLTER

MEMORANDUM RECEIPT

T0: TSS&CD

2 November 1953 DATE

FRoM: Budget/TSS

SUBJECT: TwO Checks

I hereby acknowledge receipt of the following:

Check M35382 in the amount of \$9,350.00 and check #M35383.in the amount of 374.00 made payable toas pyment for Invèice # l Subprojec 17, Project MKULTRA. 1

piease returnalgnsd copyliea) of this receipt

26 0ctober 1953

FORM NO. 38-66 MAR 1949

DATE RECEIVEO

[PAGE 16]
MEMORAIDUM FOR: CHIEP, 7LIANCE DIVISICE

C-V SURECT:

TSS/31got O2icer

Iavoioe No. 1, Suprajeat 17, Projeat Hru

Invoice Jo. 1 for Subprojoot 17 of Project MXTaA is attached.

It ta requcetei that paymant bo zaie by tvo cashier'a checka in the

azunts of 9,350.00 and \$374.00 ode cut to The

ahecks abould be seat to Chief, CD/t33 through TSs/uiet Orricer

not later thas 30 Cetoter 1953.

SIDNY COTTLIED Chicr  A Chemical Division, TS3

Attechzente: Lavoice Certirioatiocs

Distributioni Addressee • Orig. à 1 Caotroller - 1 T3s/mkiget-1v 23s/2egtatry-1 Exzc. Seo'y. Ras. Bi.-1 T3S/00 + 2

26 October 1953

[PAGE 17]
CERTI/ICATIONS

(1) "It is bereby cartirled that thia is Invoice So. 1 applying to subproject 17 of Project HULTaa, that technical perforsance dym -C C bis satiaractory, taat the work is being acccpliahol in eccordance vith the mulual acroenent raached vith @zste C that thie bill is juat ani correct acd that paymeot thereor has not yet been made.

(2) "It is bereby certiried that this invoice spplies to subproject 17 uier Project SOuLTRA vhich vas duly approvel and that tho project in being carried out ia accoriance vith the Do/? aemoruniua to DI dsted 3 April 1953, tho DCI omoraniua to D0/A datel 13 Agri1 1953, and the DCI zemorandu to the DO/A datod 19 Jure 1953.

(3) It is bereby certifiet that the scope of the progroa of outprojeat 17 of Preject MuRa has been approved.

Exea. Sec'y., Roa. Di."

[PAGE 18]
October 24, 1953

[PAGE 19]
HONADO PORICOPEOOLLZR

ATTENTIORI Finance Divisica

SUBJSOT: Projeat KWLTRA, Subproject 17

Unier the authority granted ta the menorsnhas dated 13 April 1953 frca the DCI to the DD/A, eni the further authority grantel in the memoraniua datel 17 April 1953 froa the 00/λ to the Couptrollor cn the subjeet. 'Do/P-ss Project N", end the snoraadua dated 19 Sue 1953. fro the DCI to the DD/A exteniing the authority to cover Flacal Yoar 195h, 3ubpro;ect 17 bes been approvei, ad ↓29,172.00 of the orer-all Prolect HlTaA Puxia have teen obligatei to cover the autproject'a exponaa9..

SIREY COTMLIES Chtef Chenical Oivision, T33

PROGRAM APPROVED AID REJOWZXSDI

APPROVED FOR ODLIGATION 07 YUND31

Kesearch Director

Ditar

Datel

Diatribution: Adrsoce - Oriz, à 2 Exeo. Sac'y Ros. M. » 1 TS3/3u10t-1 (4-2502-10) Tal/Regfetry -l T33/0D- 2

22 Ostober 1953

OCT28 ENTT

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SUBJECT: Project MKULTRA, Subproject 17

1. The acope of this research program is intended to cover work to be done with LSD and related compounds by -C
C- for the period ending 31 October 1954. The project will be handled throughe for -B
B- cut-out and cover purpoisacoepropotal romorato -C

2. The general object of thie project is aimed at elucidation of the site and mech ism of action of LSD by the use of isotopically tagged moleculer least three major advantages will accrue from such knowledge.First; such data should greatly facilitate the development of a suitable antidote for LSD; in addition, they should make it possible to design nev compounds having like but even more bizarre activities; and finally; findamental knowledge of the paychotherapeutic action of drugs vill be made available for future development.

3. has available to him at a highly competent group of scientiats of international reputation encompasaing the fields of physical and orgaric chemistry in adaition to those of medicine and psychology. He plans to use these people as informal conaultants in the work.

4. The funda for this project include \$7,000.00 for the aynthetic work on tagged LSD, \$18,500.00 for the' metabolic studies on such compounds,.\$2,550.00 for the 10% University overhead-charge, and \$1,122,00 for a 4% service charge by e Therefore, the total cost of this investigation will not exceed \$29,172.00 for the per1od ending-31-0ctober-1954.

5.This project will be completely unclagsified after it.leaves 一B

Chemical Diviaion, TSS

DRAFT R - A 22 October 1953

MEMORANDUM FOR THE RECORD

[PAGE 21]
PROGRAM APPROVED AND RECOMMENDED:

-A Research-Chairman

APPROVED:

APPROVED FOR OBLIGATION OF FUNDS:

Date: 28 Oclvh 1953.

Original Only - Project MKULTRA,.Subproject 17

[PAGE 22]
Septeaber 30, 1953

Daor r.-C

Pacloeod olosge find an ousline of a cropoerd sttdy of the metabolisn of d-Lrsergie Acid Diethylanid. This outline is couchod in gen-ral torae bocause all of us fael thag as ve open the inveatigatioa ve vonld like to hve our objoctives in genaral teras rather Chan in speciflo onsa. If it is iacortant - to poo. Dr.am con write out a dateiled eta:coont of bhe firet stepe that be is ging to takce vith the aid of Dr. end I cs ivo yu a detailed descriptica f the first exporinons vo vonld like to do in the metabolio procres.

Or. acortant cvostiea le the source of lssorgic sotd end derivativee. Lo you bave any mzaostions as to poople ve might.vrlte to or coaanies tht veuld do lateraeted ie collaborating vith ds. at lesat to tho oztens of pravidiag coacomndel

Another rroblom bea to do vith the report aystas. Our fizst refarence woald de to aubait an annual recort. 1t scoss to ua that snch a stody ee vo are propoains ahould not do wdertaked for a period of leta then thres pears. Io it tossible that you or soceone Sroa pour office couid visit us so that ve voald bave a battor ldea of bov ve are expocted to furaiah falormation.

Cze a ta not mntlond in the cutlin. This is ir. dr  C C→ Ma Ee bes a livaly tatereet in to coanibilitios thet nay drow out of thia study as for as olinicel ap,lications p. Ha viche to sit in on cur sonforenose as the progrsa devolope.

Another pattsr hag to do vioh Cairersity owerheoi. Do poa bave a nolicy alpcdy fornalatod das bes rivon ve the followins stateoont to send yoet

aThe ovorteed coet of scnsored reaerch at the Univerrity ca -B is ecn uted esch year for doth the Colloce of Arte and Scicnce (orgnio chonlatry) and. the Medical School (pheroncology). Cn cost-reinbuarsonest ccotracts, the over beed is emreeasd ns a porcentece of solariee end voces and the rates for the cclcadn crenta-in-aid froa foundations, pationel sociotloa end orginizaticas, it is the policy of the Vaivereisy so sccent the establiabod ovorbecd pollcy of the csnting aconey. Vhen such policy providos lesa then the Caivorsity's overhead cort a diroct choras ie mede to the krsat for the Cniveraity 's cozt of social secnrity. group insurancs end retirezont benefite. Thgse costs cro doterpinod each yoar snd expressod o\* \* pereontsgo of sslarios and wegost for the calondor yoar 1953 the Brata in the Arte Collere ts  and in the Hedical Echorl

L 2cheth

[PAGE 23]
Sinco ths etady of the pstabolian of LsD impliae,to re oponing the covsibility of davaloping a chemo-thorapoutio ogons for mntal diasase. I can agsure you that the problea secos to so to tats a fizot-renk iaortoncs. I can sgaure pou that is is vith kosa enttcipation that. this progrra vill be uoder taken by our groap.

There may be a nomber of aspoota adout thio rroposl that naeà to de diacuseed. I ereot to de in vasnington briofly -C I bopo I havo the apportunity of talking vith you if yea no desire.

Toure vary truly.

Encloure

3eptambar 30. 1953

[PAGE 24]
G.31 Puih 17-14

\$7,000 With Aduice consultation -s wit

Metabolism Program

\$18,500

Salaries Dr.(director of program) \$5,500 Dr. (part-time) 3,000 Dr. (biophysical parts of investigation) 500

Apparatus 5,000
Expenses 2,000
Travel 500
Contingency 2,000

\$25,500 plus allowance for university overhead

25500.00 gmt 2550.000102.0H. 11 22.0042 srmid 29172.00 titl zn 15 gn

1070

[PAGE 25]
VEIORANDUU FOR: LASO DD/P/TSS

SUSJECT: Request for Cervices of G

i. As indicated in the writer's conversation with 降A it is rocuested that. the w be asked to put a G P.H.S fora in the hands oreee 了C

C → 2. is at present under contract with an Agency "cut-out" and ia doing unclassified sork for this contractor for Cly TSS projects.

3.. Other possible means of initiating clearance of have been reviewed and discarded mainly because they would Jeopardize the security of "cut-outs" and cover stories used in tho past with this subject.

4. It ia requested that action be taken in this satter as socn as possible and that tho. completod form be roturned to CD/TSs.

Cistribution: Addrosses - Orig. &-l CD-1V CD Chrono

Chief, Cheaical Civision, TOS

9 Decomber 1953