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(b)③)

Could you supply me wi:th an additional amount of Corynanthine? We have not been able to show any significont blocking effect when l5 mg. of this compound were edministered 30 minutes prior to 40 microgm of LSD-25. We are now civing 15 mg. every fwo hours for three doses. This, of course, means our consumption is rather high at this fime.

We have now completed fhe first triais on the effects of CA-lol on thecardiovascular response to stonding. All 3 peiienis showed marked'elsvetion in pulse rate, à drcp in both systolic and dlástolic blood pressures, with marked nerrowing of the pulse pressure. This effect was evident two hours after 2 mgr of the drug had been glven, appeared to be maxlmal eight hours after the drug had been given, ind were stlll present 15 hours after the drug. After 2 hours. although responses were in the normal range, they were still higher than pre-drug controls.

Very sincerely yours,

Harris dsed Harris isbell, M.D. Director of Reseerch

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Hi:rn

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.TH, EDUCATION, AND WE ?EEEDSRNOIOURVTALSENCYPUBLIC HEALTH SERVICE

IN REPLYINO, ADDRESS THS

Lexington, Kentucky . 21 July 1954

NIMH Addicticn Research Center