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REPORT ON K-302

These experiments were carried out (a) to determine if K-302 and a crude preparation of a fungus would induce psychic changes in man, (b) to determine the dose range necessary to elicit a reaction, and (c) to obtain information on the clinical characteristics of the reaction.

Methods: Eleven Negro male former addicts who were in good physical and mental health served as. subjects. All these patients were familiar with the effects of marihuana, LSD, and were accustomed to the experimental environment.

General Conditions: All experiments were conducted in a speciai ward. Men entered the ward on the, night preceding the test. They were awakened at 6 a.m. Drugs were given .orally with the patients fasting. Patients were observed after 10 minutes rest in bed but were free to mingle with other patients during intervals between observations.

Measurements: The following measurements were obtained at hourly intervals once before, and eight times after administration of the drug:

1. rectal temperature;

2. systolic and diastolic blood pressure;

3. puise rate;

4. respiratory rate;

5. pupillary size;

6. threshold for kneejerk;

7. LSD questionnaire;

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22 October 1958

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8.notes on behavior.

Drugs:  K-302 was dissoived in 3-5 cc. of ethyl alcohol, and diluted in distilled water to 30 cc. The crude fungus was dispersed in water, using a Waring blender. Piacebo was spinach ground in water in a blender to simulate the appearance of the crude fungus.

Doses used are shown in the tables attached which also give a

qualitative assessment of the resulits on the various measurements.

In addition, data on patients receiving 2.5 grams or more of

K-302 (4), or 15.0-20 grams of fungus (5) were analyzed and

averaged according to the, system used in assessing LSD effects.

Results: K-302. Pupillary dilatation was noted in evary case

even with a dose of 0.3 grams. Change in blood pressure and knee

jerks did not seem significant until 2.5-3.0 grams were given.

Subjective effects were not noted consistently untii 2.5-3.0

grams were given. All 4 patients receiving these amounts became

elated, silly, and giggled. They reported nervousness, vague

fears, changes in body sensation (numbness, light, etc.). One

(Foster) gave a picture very similar to LSD (euphoria, silliness,

visual distortion, depersonalization, lights, colors, etc.).

Crude Fungus. Definite changes in blood pressure, pupila

and kneejerks were observed with doses of 10-20 grams. All

patients receiving 15-20 grams had subjective effects, most

frequently described as being those of marihuana. The LSD pattern

(anxiety, perceptual distortion, hallucinations) were seen in 3.

Report on K-302

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Placebo. All results were negative.

COMMENTS

The results warrant the statement that both the crude fungus and K-302 have sympathomimetic activity and will induce psychic changes in man. The data are not sufficient to characterize the reaction completely or to assess with any exactness the relative potencies. About 2.5-3.0 grams of K-302 seems roughiy equivalent to 10-15 grams of the crude material.

Plans: See letter.

Report on K-302

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BP - Systolic blood pressure

KJ - Threshold for kneejerk

\+ - Indicates that measurement judged positive by inspection

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AVERAGE CHANGES IN PATIENTS RECEIVING 2.5-3.0 GRAMS K-302, 15-20 GRAMS OF CRUDE FUNGUS AND PLACEBO.

X = Represents areas under time action curves.

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