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suBject: Hiytospray, apules, etc. (Bluebird)

Reference is made to our recent convorsations regarding the hypospray instruncnts and varicus tyçes of ampules that can be made for use in the instrment.

The "B teza has Fiven considerable thougit to the possible uses of hygospray and all concsrned aro azreed that this instrument (or varistions thereof) would te of extreze value in certain operations. There are, however, nany questions thet arise and require answers in this œonnection. The cost obvious are set out belot:

1. The ropular comercial YFOSPRAY discharges a lcc apuls. Is this tho only size hypospray made or developed œomercially or exerirontally? A 3cc or even a 2cc, if vorkable and clinically sound, would, i is belioved, be of greater uss to us than a lcc instrurent. Full details are needed including all kona tests.

2. Very little is kow about the various types of anpules used in or maie for the hypospray (commercial. or exerimental). e vould like to obtain all available inforation in this connection.

3. álso in conaction with (2) atove, re would like to kow hct concentrations of liquids and solids, types of liquids and solids have boen tosted in the hycospray and vith what results.

L. Te would liko to knów if the standard lcc hypospray is nade or has been zade in any other forn, shape,. size, or reight. The standard htospray is quite heavy and a lighter, rore easily carried model would be of great help. Also, has an instzvant beon built having a.double barrel and capable of firing to ampules simultaneously?

5. The hypospray was invented or developed by Jares l. l'cKibbin an officer of the R. P. Schorer Comp, of Detroit, ichigen.. Eoth lclibbin and R. r. Scherer are highly regarded and recutable ináivicuals according to IesS confidential inforation. e would Liio to inow, if possiole, that excrinental :ork these individuals (or the R. P. Scherer Coro.) have'done on the hpo spray or similar instruonts end the apules that the have csu and testod, Ee uld like to ko if the R. P. oher: corç. is still ain aules for the hyposoray, althour: ino richts to the instzument  roparantly hcer old to he E. R. Squicb Company, Brooln, ler lork.

Office Memorandu • UNITED STATES GOVERNMENT

DAT: 21 February 1951

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6. Since all rights to the hyposoray are now owmcd by tho E. R. Souibb Company, Brooklyn, liew York, we would like to know if Squibb is nanufacturing the hypospray now; what, if any testing or new dovelcpnents they have made on the hypospray; aro they making their orm ampules and if so that sizes, types, solutions, contents they are using. e should also like to kow how we cen nako imediate purchase of hypospray instruonts and apules (see folloring).

7. e vould also like to now tho nanes of individuals (doctors, technicians, exoerinentors) wio have worked on or used the hypospray and what tests (and results) have been made by these persons. Further, if any institutions, hospitals, clinics, etc., havo made extensire use of the instrument re should like to know their wanes.

Based on "B" experience and research to date, this office mould like to secure immediately via direct yurchase or iy contract arrangenent six (6) of the standard comorcial HYrOSPPAY instruments. In addition, arrangenents should bo nade for the nanufacture and purchase of tho folloving aapules for the above instrunent:

300 sodiun arytal (ons grain each)

100 caffeine sodiuz-tonzoate (tuo grains each)

100 caffeine sodium (seven and ono-half, grains each)

It is Lelieved that the Squibb Comary would be the only prosont source of hymospray instruments,. however, arpules can probably be pyrchased fron both Souibb and R. P. Schsrer Coro., at Detoit, !ichigan.

In the ovent, it is felt that these iters rould de difficult or slot to obtain throurb normal Agcncy chrunels, this office believes that they could beurchasod(ng)diroctly.

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Subject: HYPOSPRAY

Additional information concerning the use of the hypospray instrument is requested as follows:

1. The hypospray instrument, as presently designed, discharges a lcc ampule. Has any experimentation been carried out or has an instrument been developed which would permit the use of a 2cc ampule or even a 3cc ampule?

2. The present hypospray instrument is quite heavy in weight. Have other models been developed using lighter metals which permit an easier handling and carrying of the instrument? Also has an instrument been developed utilizing a double barrel and capable of firing t:wo ampules simultaneously?

3. Are there available any teports on the use of the hypospray with results of research on the effects of various drugs and scrums utilized in the hypospray?

Any information on the above would, be appreciated.

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Subject: Hypospray

Request that arrangements be made for procurement of the following supply of ampules for use in a hypospray instrument:

300 ampules sodium amytal (one grain each) 100 ampules caffeine sodium-benzoate (two grains cach) . l00 ampules caffeine sodium (seven and one-half grains each).

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Army Perfecting 'Gun'. For Painless Inoculations

Advanteçes of New Method Obrious in Wartime

By Thomas R. Heary

A "hot" gun by which large sroupe of peoplecan bs Lcculated suekly and palnlcisiy ls teinz perfceted at the Army Medical Serrice Graduats Srkcal rs

By means e' t vaceimes, snitlotkes er morphine are shot egainst tt akin uader high prersure.

Its adrantazes would be obvicrs sith ens threzt of bloogical tarfire whes it might te necesssry to inceulate an entire population. It aiso, Army Ccctors beleve, woutd servs well in the ezte of troops erdered sucseniy overseas.

With a typederrie needle it is necersary to fl and sterilice after cach isjection, ztime-corrumins process: Usa of the needle always is somewhat painful and many persons have a great psychotegieal dread of it.

The rew rthod requires no teede. It is abseluter painless. The sensaticn. is' ro diterent frem that causcd dy a water spray under hiih pressure.

Nethod Areids Infection.

Other impertant advantages pcinted cut are:

With hypodermie reedles there is some Canger of transmiting infcetion. sueh as ssphilis, maleria or yellov jauncice. Ta's is cspecisliy true when larze numbers must be treated in.a huny.

Since there is no penctratien of ths skin. exctpi Ly the vaceire seif, no Rerilization is necded. Practicaliy no xperience or training is necessary. Uss of the necdle is a job for a Coctor cr rained technician. This sould be very nportant In rch an epcrezes zs à ciss bombing.

.When predéeed in quantities. let-inection apparatus sill be relatively inxpersive.

There Is eccnsionsl fafure of the fct nerstrte the scn of persons with artioulary thick hides or with thick ucber." A ccatrol that wil ensolo ie operater to vary the prezsure acrdicg to the tadividual is teinz worked

Tae metked is vorthlers far any tut iseters under the skin. R esanct used for ineclors ino te

Jet Injections have bcen' In use,"but on a very limited scale, for some yeirs. The Army's apparatus is a great improrement over any used in the past. Discovery of the meticd Is telieved to have come from observatioas of automobile oll being forced throczh tho skin of mechanies. It also was noted that Ane jels of oll at high velocity. as from a kcaking hydraulie lne, could penetrate human skin and lcave littio or zo mark.

The epparatus, it is tmphasized, still is in the experimental stage and wil not be used for scme tie.

.A new antiblotic actire zpairst amoebae ln diluticns as zeeat as one in 130 million has been reported to ths American Association for the Advante-. ment of Science.

It is extracted from a spccies of mouid, like pezieilin. The new substance, deseribed by Dr. Max C: McCowea and his asscciates of the Lilly Resesren Laboratories at Indlanapolis, appears to be the most potent sgent ret found against the microscoplc animals responstble for, amoebic druentery and many other maladles.

New Amoebic Antibiotie.

The new antibiotic, cal'ed funaziln, sems to te speciäe asainst ancebaa. Tats shew that it appateaty Sas lts ¿.Tect against ciher micrc-organisms such as bacteria, funzt or viruses It is the ürst subziance yet fcund which setmus to be speciac agztnst stoebae. Even In crude form I is efective. in Jabo.atory tests with nteais, in dilutions as high as one part to i6 muillion.

The principal tests to date have beca with experinental inicctions wilh rabbits. It was found, according to Dr. MeCowen and his associates, that tho animals could be completely cured by the micruscopic organism in four divided coses administered over two days. Jess than 100 milligrams per kllogrm of bedy weight was adminisiered, Quite simllar resufts have been brought zbout with young rats.

Tests with humans, where atacabee discases auch es dysentery are likelz .to be very serious, ztait furtter experiments with animais. Maladies erused by these oreanisms are likcis to be extremely serious and scnetimes tend to ruan ln epidemtes. The bseterietozists cmphasie that their rcport is eniely pémmary. ant they ra no have detrimental efcets co humans.

Tray have Cuaonstrated that it has. ro tfcet on iafuenza la miee.