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1. Sometime ago, this office forwarded tojxxt:seasrorea number of documents for his examination and study. Anong these cocuments was one in which information was requested (along with possirle purchase) of hypo-spray, ampules, etc. forfuture use ry pluchird teams.In view.of the fact that a possibility exists for a special trip by Fluebird personnel in the near future, this information again tecomes pcrtinent.

2. It is, therefore, respectfully requested that your office, through all possible channels, obtain information concerning the latest use of the hypo-spray instrument and related devicns, including possirility of dosaçes of interest to Bluebird. In addition, it is also requested that you obtain for Bluebird use hypo-spray instruments, ampules, etc. with the necessary instructions for their use.

3. In the original menorandum referred to in my first paragraph, I helieve I set forth some basic information on the hypo-spray which may he of assistance in this matter.

4. While nothing definite has been determined as to a possihle Bluebird trip, it is obvious that one is under consideration and I have recently been informed bysssthat the services of an H.D. bave been made availahle in the event a trip is made. Je will, of course, keep you informed as details are given to us.

Date: 30 0ctober 1951

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1. In line with recont ceuversations belween members of this steff and the medical officer assigned to the "Artichoke" work, it would appear from a medical point of view, that hypo-spray, at least in its present conditionand using using presently knowu types of chemicals or drugs, i. is not an effective instrument for the "Artichoke" work. lievertheless, . because of its convenience, thestandardizatien, and certain other factors, it is felt that every effort should be made to determine whether or not a hypo-spray or a variation therecf could te used in connection with "Artichoke".

2. As we understand it, at the present time there i; no drug or 1 chemical that could successfully be used ty the present hypo-spray instruments for the ottaining of a,twilight sleep. condition. The hypospray is, at present, capable only of an intramuscular injection and we!have no knowledge of hypo-spray being used intravenously. Furthari more, such drugs as we are familiar with are not effective when used intrammuscularly and are at their best either used orally or ty a method of venipuncture.

3. However, the writer believes a possibility exists that. at present, hypo-spray instruments could to used for the injectien of caffeince, picrotoxin, or possit-ly tenzedrine though we have no literature or information to support this belief.

A

Office Me: 'OrAndU · UNITED STATES GOV INMENT

DATE: lh Locenter 1951

sUBjECT: Hypo-Spray, Ampoules, Etc.

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b. Along with this current thinking, it is felt that your office could, through your liaison channels, have experts carefully go over the entire hypo-spray protlen hoth as to chemicals for use in the ampoules and the designing of special type, light. weight instruments possibly shaped like a pountainpen or pencil that. might be used to gain quick control along "Artichoke" lines.

5. While we have no specific informaticn of new chenicals or drugs that could be used in these hypo-aprays, it is, nevertheless, felt that a strong possibility exista that a chemical or drug cculd be found which could successfully be used in a hypo-spray type ef injectien that would assist us in ohtaining the necessary control.

6. The devolopment of such an instrumont as mentioned atovs and the co-development of chemicals along these lines that could ts adninistered by an average agent in the field with some degree of certainty, would be of tremendous advantage as you know. A "pocket model" such as one resembling a fountainpen, if it could be developed, would be a remarkarle and valuable weapon. The storage of extra ampoules for the use in the "pocket model", it occurs to me, could very easily be concealed in' an instrwnent resembling a pencil or another fountainpen. It alsc appsirs obvious that this type of instrument, could be used for lethal work if needed.

7. In connection with the above, it is suggested that your office might designate someone to visit who apparently

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developed hypo-spray, and the
who did basic work on this device, and at present, it is believed, are manufacturing ampoules used in'the modern hypo-spray. Furthermore, it seems certain that
might possibly give us valuable information in this connection since it is my understanding that the instrument,being uaed at by tho In vaccinations and H similar type injections.

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Hypospray

l. Feferenco is nade to. our rrc…t conversationa regardins;, nossible ure of the llypospray inotrument and tho various types of ampoules that could be developed for use xith this instrunent in conncction with Agency work.

2. The llypospray way invented or developed by

mamufacturer of pharmaccutical capsules.in

He has numerous other tusiness intcrests.

4. In 1950, this Agency conincted a covert investigation of

This information, which is hold in the Artichoke [iles, was Favorable in all asrocts.

5. This invontigation indicaled, amon: other it-ms, that cortain individuals rosiding or living neariashington had don sono work in connection with the use of the llypospray apparatus. Theso individuals

15 Octoher 1952

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6. The report reflocts that somotime in 1950, the scssir.

in the Hypospray davice to the. but whether this involved experinental models and laboratory information concorning the development of tho lypospray is not reflected.

7. As you know, the Artichoke Taam has, Tor a considerablo poriol of tine, considered that the liypospray, if it could be used under cortain conditions, wouid be of extreme value in field opnrations.. Tiere are, however, many questions that have arisnn and require answers in this connection. The writer is sntting out the most orvious inmediately below for your consideration and also in tne event the ledical Departmont of this Aeoncy takes up this ma:tor:

A. It is believod that the itanuard conmorcial Hypospray discharges a lec. anpoulo. Is this the only siae nade or devoloocd commarcinlly? would a 2cc. or a Jcc. Hyposnray, if workable and clinically sound, be of greater valus and use than a lcs iaeimsant?

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R. Very little is known al ut Llo various types of ampoulos used in the !ypospray either conmercially or experimontally. xhat informntion is availablo in this connection?

C. Furthermore, it would be of intorest to know what concontration of liqulus and solids and what types of liquids and solids have been used in the Bypospray ampoules and with what results.

D. Since, as far as it is known, the liypospray can only bo used intraauscularly or into the fatty tissues ol the body and not intravenuousiy, what orugs or chemicala could re used in a hypospray instrunent that would:

l. Produce a coma (with particular emphasis on speed).

2. Produce forms of muscular failure, possibly alons linos of curcare roactions.

3. Produce lethargy, disorientation, cuphoria, intoxicnlion, o'c.

b. Produce nausca, cramping, or acute illnuss.

5. iroduce a lothal nffect.

E. Ihis Staff has examined the standard comorcial Hypospray. In its present form (and also in the pistol-grip type as used atetssr and elsewhera), it iss and not capatlo of

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simolo conceataent. Je shotl! like te knoo if the Hypospray has been mado in any other form, slape, size, or weight. i lighter ;ockt-tyl mudol, which would rsenble a fountainpon, sonlt te of naterial arlvantago. In aduition, w shonld liko to knod if and instrument has heen built laving a double barrel and capahle of firing two ampoules simultaneously.

F. Since a possitle covort use of the inutrument is heirg considered. and since this usc might bo under rapid, rough, and non-clinical condition, w? snould like to know whether or not the Hypospray can te used Lhrough normal clothing, including possirility of infection and whether or not a spccial Hypospray could be doveloned thnt couid he effectively cischarged through normal clothing.

C. We should like to know whether the :iedical Division, throurh itscontacts could interviewtes and thentoy Kacgiea technicians to examine experimontal aodels of the lypospray instrumnnt which certainly must havo teen developed in conncction with the work on the liypospray. oe of Whse rouels, while not l cinc corrrerically prnctical nizht te extremely useful from our point of vies if pre;rrly modified or developed.

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erofeastonntly uas a: axcolieat trieg resstatior.:ari taeon renearen in connetian vitù Lno project 4itc; é, 47 t0.ai7) olvision was Infonaed ty cortain eflicinls of tne wy in E fia dslng: advarcod aork In conneetien uith the nrposprs, (avieea.

?in tiz cnciio.a ni to ea ie  ptsarine ainr m ditector of pe ereh a w9s 1evorted te ds

3. in order to sea ropostod a special contact tyre of cloer nco thrnuri : neoritv uicn sas obtainad larxediately mi aaring tne ue  uf 15 daneary 1 13, Nislte

11. い-1 ti pain"alr a Ue Coreaay sas ahelsine work on tae hyreraay st. be  recent Mee. s atatod they had e rrant many uilferent types of hypoaprny--sowa sochanteally pozered, sons powered by pa. ari sons posored by uydraulle devics.. siaiel Liat at Loa ironpt, time,} ased an thir not, he folt that. im rsdiete wse of hycozeray as fer as j.jutllo is cucorned did nat npasr foaalble, but atatod he thomght zoup wovk would probably !n donn in connaction uith ultra-iteh prprur hypospray detices Lhiat nicht b mccossful.u i- ormarin a rerort Cur te "edics) ivitior tn Uhis conneetian ari copioe wilt te given tia orfien upon copletion.