[PAGE 2]
In thu courae of theso experiments, the men ware fod a certain amount of the cannabis tinoture by mouth. The results of these tests were also unsatisfactory, in that the men mifferod consider-: able. phyeical disoomfort thout disclosing confidential information which had been furnished them.

It was then decided that a further set of tests should be made at the wherein we would give oannabis by mouth increasing the dose gradually in the hope that there would bo oertain point at whioh the subjocte would talk freely and yet not suffer phyeical discomfort. Treatod cigarettes were used as an adjunot in the experiments.

Through we were able to secure eight enlisted men
who volunteered for tha purpose. Howevers the results of thate teats
again negative in that the nen suffered phyaloal discomfort and would
not disouss confidential mattors. It developed that one of the men, , suffored sone after effeots and so was sont to the Honaver. HOnGYOr atated that thià man was oe Jtatod that thle han was or

unstable temperanent and that he had been given unusuaily good treat. ment in tho Hospital. felt that the return from such treatnant to the oump might have bean a more iaportant factor in causing the man'e condition than the drug itselrs (As of this daté) approximately hix weeks after the experiments, the nan appears to have almost entirely recovered and wili likely be ordered back to oamp.)

At a further meeting of the domuittee, it was decided that oral administration wad an unsatiefaotory ethod and that experinents should be made with variouà nethods of inhalation. then conducted tests by putting tetralydrocannabinol abstate (axtracted fron Indian hemp) on ohardoal which was thon lighted and the vapors were allowed to panetrate in the roomj also by spraying the hoetatà into a roou. Ir both cases membera of our owd staff wara used as subjeots in the treated atooaphere. The results of the oharooal test were nagative; but it was thought that the spray method ofrerad soms pronise. Never. theless, it was deolded that the use of cigarettas, treated with the aoetate, might be the best method of dperatian. Therefore, md carried on éxtensive.experinents with our owd stafr and with manbers of the cornlttoe, te dotermize the efrects of suoh an aoninistration, and alsd to detersihe the quantities or drig to be tsed.

Thesd tests gard good resulte in that it appeared possible to adainister 2 an amount of the materlal whioh would bring about a state of irrosponsie biiity. cansing the subjeot to becone loqunoious and free in his.

General W. J. Donovan

21 Juno 1943

[PAGE 3]
inpartation of inroration (sone of whioh it was felt he, wouid
certainly not divulge exoept under influcnco of th drug), yet
without causing unplaasant symptoms durinc, or after, the teats
Another tost was carried out by in which he gave
treated cigarettoa to a lew York gangater, but without the subjeot
kowing of the treatment: The gangster becane voluble and impartad
much seoret informatiori as-attested by the attmohed copy of s report. Howover, the ganceter attributed his volubility
to the faot that he had drunk ade brandy.
The cigareute experiments indioated that wo had a mochanisri.which
offered pronise in the relaxing of prisoners to ba interrogated.
As the committee agreed ith this conoluslon, we thon went to.Genei
Donovan and at hir suggesttan talked with
shanneled us to who tion of vIs.. At thé tio of our visit to s ofrice, of CE taiked with the Gonoral
for swo time, but wo did rot talk with inforued
us that tho Gonoral apparently did not want to liow more about tho
subject. Thereupon, General Donovan ohannoled us to
with wha we discusadd tho subject in sone detail and who proved to
be quite interested. Shortly afterthia mneuting with
he and: i visited our offioes, ánd we then gave then the
atory again fully. then sent to us
of Oll, to whon we gave the whole étoryi together witha paokage of
the treated cigarettes.. The Commnander was very muck intereated but
doubtful as to how far he could go with the nethod.."

Assistant Director Rosearch and Developnent

Genoral N. J. Donovan

21 June 1943

[PAGE 5]
On the day or tho experinant, I roquestod subjoot to visit ne at my apartaent in Hew York on the protext that I wauted to talk further about plans to utilise hie services in Italy. I had. previouely propared oigarottes of the sano brand I knew hia to snoko loaded with both .04 grams of Loowe'e acetato sid .02 graua of Loeue's acetate. Subject entored the apartment at two p.n. and at that tine statod that hs could not ramals long as he had a friond waiting for him in an autonobile cutaide. .After a short conversution rogarding the pretaxt on which ho had come to the apartoont, I gave him an .04 oigarotte at 2:10 p.m. At 2180 p.m.s having noticéd no percoptible effeots, I gave hin a .02 cigarotto. Shortly tharesfter subject becane abriously "high" and axtrenoly tarrulouse Ho monopo lised the conversation and was exccedingly friendly. I turned the donverwation into "Enforcenent" chamela, whereupon with no furthor snccuragenent subject divulged the following inforsationt

[PAGE 6]
The foregoing information was givan over a period of approximataly two hours. On one bocasion, the subjeot said, "Whatever you do, dodit ovar use any of tho sturr I'n telling you". Subjeot kow that all or the porsons he had namad were well kowoi to me and had bean the objeots of close inrestigation and scrutiny by the Treasury Departmont over a poriod of years.

During thie conrersation subjeot exhibitod no signs of diacomfor and apparently did not realise he was umder tho inrluencs of a drug He had completoly forgotton the man who was waiting for him in the automobile outaide. At 4is0 p.z. I found it necessary to interrupt tho flor of conversation bocause othor persons were expeotad and be then left reluotantly. Once started on the subject of oriminkl motivities aubject roquired no ancouragenant to dontinue talking and nonopoliked the convarsation.

[PAGE 7]
I suggested that subjedt lie down and led his to a couch whera he collapsed and was apparently unconscicua for. a pariod of approrimately one hour. At ths and of. that tins subjeot sat up and somo disousaion was had relative, to the oauss of his trouble. I suggeated that his condition was due to weakness from having not eaton, conbined with the andunt of physio be had takon and he agre that this probably was the oase. We thon went to. dimnor, at which time ho ate a bearty msal.. Approximately an halr-hour later he sta ed that ho felt finos..

During the poriod prior to hia coliapse very little conver sation war had of signiricanoe oxcopting that junt prior to his collapst subject volunteered that he dould arrange to have mirdared, if I thought that would be helpful to the war offort. I. explainsd that any such aotion would merely make à martyr, but he ropoated that he could havo it accapliahed by aomo eployees úf Jaion. I dissuadod hin frad duoh motivitys

The folloring day, on Hay Slot, subjoct cane to ry apartment at noon and offered to drive ma to Long Island where ay wife was convalescing fro ilinass.. En route to Long Ieland,I guvo subject an .02 cigarette. Ho was driving and ezhibited no visible effeot. He engagod in conversation, however,. and on thia oocasion gavo me the following informationt

[PAGE 8]
Aithough subjoot's condition the provious day was fraquently loned and disoussed, he did not have a parcoptible effoot from the .02 cigerette adiniaterod in this cnse and did not commont on any abnorunlitics of foeling.

Ail of ths foragoine inormation could be dazaging to tho subjoot and is a olass of information that subjoct would nover cive under ordinarycircumstances. Thero is no question but that the aduinistration of tho drug was reaponsible for loosaning the subjoot tongus.

It is believod that in the futurs adniniatration of the drug should be hold to the .02 oigarotte over a period oft ime suffioient to bring about dosired results., Exporimonta should bo conduoted undor such conditions, that sufrioient tine will be allowod for ths nilder oigarettos to take effoot, and no interruptionsshould bo pornitted to occur.

Copiód 6/19/48 by mod.0. foz