[PAGE 2]
Date Initiatedı 24 Karch 1955

Date Expires: 1 June 1962

Funds-current yearı \$30,740

Purposct Phanacological and clinical testing in anieils and volunteers of chenicals end biocheuicalsvhich alter-bebavior. Próvidce consultation on special prodlers of TSD interest. 1

Statust Study cozpleted on threshold doses of LsD-25j.a cethod for exploring antaçoaisa of this dnug dy other.agents. Work hes been initiated to evaluate cozpound prolucing aresia and háving en alcohol Jike effect on behavior vill be:started.-Evalustioa ofeffects of coobiration of drugs of interest-to TSD is 1/4 copletef

47-2

-ProJect 1EULTRA, Subproject 47

PPSIFFER

47-2

[PAGE 4]
March 25, 1964

Dear KOC

Attached is our 1963-64 report/and proposal for continued research support by theara for the coming year beginning June 1, 1964. We hope that the report and the proposal mect with the Board's approval so that you can advise us positively when you visit us in the near future....

I shall be in a on Saturday and Sunday, May 2nd and 3rd. I can report in on Friday, May lst in regard to a possible conference if this is necessary.

Our financial report for the present grant year will be sent shortly after June 1,1964.

Yours sincerely,

Gul b.OfW

Carl C. Pfeiffer, Ph.D., M.D. Head, Section on Pharmacology

CCP:tt enc.

17

47-4

HUMPHRY OSMOND. MRCS, LRCP, DPM

State of New Yersey

[PAGE 5]
BEHAVIORAL ACTIVITIES SUPPORT Behavioral Control Matcrials (VIa) Branch BB Category-(formerly IIb)

Project Title N.A.Item Classification N.A.

Unclassified MKULTRA Crypto Classification. Project Crypto A

: N.A. Project Engineer. Branch Project No...

Dr..C. C. Pfeiffer Contractor

Contract No.Subproject47 Task No. N.A.

Type of ContractNKULTRADate InitiatedMarch 1955

Cost\_ S25,000.00 Completion Date Continuing (renewed April 1962)

Purpose: For pharmacological and clinical testing in animals and huma: volunteers of drugs altering behavior.

Status:: Clinical testing programs involving evaluation of specialized materials are proceding according to plan.

Requirement: Internally generated in TSD.

Date 5 September 1963

[PAGE 6]
Date 31 October 1963

BEHAVIORAL ACTIVITIES SUPPORT Btánch. BB Category. Behavioral Control Materials (formerly 1Ib) (VIa)

Project 'Title N. A.Item Classification N.A.

Unclassified MKULTRA Crypto Classification.. Project Crypto : A

Branch Project NoN.A.Project Engineer

N.A. Contract No.Subproject 47Task No

March 1955 Type of Contract\_.. MKULTRA\_Date Initiated

Cost\_ \$25,000.00 Complelion DatéContinuing (renewed April 1962)

Purpose: For pharnacological and clinical-testing in animals and human volunteers of drugs altering behavior.

Satisfactorily terminated. Contract replaced by MKULTRA 144 Status;

Requirement::Internally generated in TSD.

FINAL

[PAGE 7]
FOAH 282

[PAGE 8]
· T Bttr  r Tve Mncoc tng e ece or ppr ate r e e    es aos e te noe 2512

e    e       l e  a  Sut t e e at z o rt  s  e v       i        nsr o  r   r rr nor e er e er c ttr   e  e e r er e

cor ee r  e r  r ar rr tr J   r se oat o re  r ts.

pod Burtumoe d o Butt a e Butpueisnose nns to   e t t o o e Hav be ne n

[PAGE 9]
I Ph: eriythtecseorr.l

25 July 1963

[PAGE 10]
Dear Dr.C

I have been informed that your granting comnittee has again agreed to support our research for-a-one-year period begirning June 1, 1963 and extending until May 31, l964. On behalf of the New Jersey Nental Health Research &-Development Fund, Inc. and my co-workers wo wish to thank-you-for-this-expressed confidence in our originality and productivity.

Attached you will find a succinct sumnary of our expenditures on the l962-63 grant. Exact detailēd expenditures are.available. in the office of the Fund.

Best regards.

Yours sincerely,

Earl Ofil

Carl C. Pfeiffer, M.D. Head, Section on Neuropharmacology

47-8

giar m Nrmu oeiory State of Nem Fersey

BUREAU OF RESEARCH IN NEUROLOGY. AND PSYCHIATRY C/O NEW JERSEY NEURO.FSYCHIATRIC INSTITUTE BOX 1000 PRINCETON. KEW JERSEY

May 24, 1963

CCP:tt

[PAGE 11]
Annual Grant to N.J. Mental Health Research & Development Fund, Inc. Rescarch Project of CarI C. Pfeiffer, Ph.D., M.D.

Reccipts

\$25,000.00

Expenditures

Salaries
Wages
Expt'1 Subjects
Travel

Total

\$19,635.54
3,546.49
878.00
939.97

\$25,000.00

Carl C. Pfeiffer, PH.D., M.D.

h P.Pared Henry P. David, Ph.D. Secretary-Treasurer N.J. Nental liealth Research and Development Fund, Inc.

I certify that ee-viro  ater!als have been
Fatisfactorily re- expenöiturcs
were incurred en oriizteness A . 2 5 J0L 15E3 Dates

47-8

June 1, 1962 to May 31, 1963

INV 13

[PAGE 12]
Branch. Category Echavior Control -(II)

Project Title. N.A. Item Classification. . N.A.

Unclassificć MKULTRA Crypto Classification. Project Crypto. A

Branch Project No. N.A. Project Engineer.

Contract No. Subproject f47Task No.N.A.

Date Initiated Karch 1955 Type of Contract TULTRA

\$25,000.00 Completion Date Contimuirc (renewed April 1962) Cost

Purpose: For pharmacolocical and clinical testing in onimsls and hunan volr. of drugs altering behavior.

Clinical testing procrams involving evalvation of srecfalized anterirls Status: cre proeeding according to plan.

RSCIREMENT SOURCE: Internally Censrated in TSD.

SET DRUTE

21 PArvry 10ć Date.

[PAGE 13]
BranchBB \_\_Category Behavior Coatrol (11b)

Project Title N. A. Item ClassificationN. A.

Project Crypto. MKULTRA Crypto ClassificationUnclassified A Branch Project No N.A. Project Engineer.

Contractor Dr. C.C. Pfeiffer, New Jersey Nenro - Psychiatric Iastitute, Princetoo, New Jersey

Contract No Subprolect f47Task NoN.A.

Type of Contract MKULTRA Date InitiatedMarch 1955

Cost \$25,000... Completlion Date Coatinuing (renewed April 62

Puroose: For pharnacolocical and cliaícat testing in aatmnals ani humaa voluntecrs of drugs attering behavior.

Status: Vork scheduled for FY 62 has been complcted and a saticfactory final report has beea cubmitted.

SECRET

Date 23 July 1962

[PAGE 14]
NEW JERSEY MENTAL HEALTH RESEARCH AND DEVELOPMENT FUND, INC.

Trusteer

JOSEPH M. TÓBIN, M.D, Chairman• PAUL HAUN, M. D, Vice Chairua• HENRY P. DAVID. PH.D, Sestary Treasurer V. TERRELL DAVIS, M.D. • MAURICE G KOTT, PH.D.• DOUGLAS H. MACNEIL • LLOYD W. MCCORKLE, PH.D.

Addrens Correspondence to: Henry P, David, Ph. D. Secrelary Trgasurer 1 JN Len Trenton B, N. J.

June 1, 1961 to May-31, 1962

BURFAU OF RESEARCH IN NEUROLOGY AND PSYCHIATRY SECTION ON PHARMACOLOGY

c/o Ncw Jersey Neuro-Psychiatric Institute Princeton, New Jersey

RECEIPTS:

November 1961 \$ 15,370.00
February 1962 15,370.00

Totai Reccipts \$ 30,740.00

EXPENDITURES:

Total Expenditures \$ 30,740,00

I have cxazined and approzed the submitted exjencitores. kn

1P.Pauid Henry P. David, Secrctary-Treasurer

derl . Glle

Carl, C. Pfeiffer, Ph.O/,H.D. Principal Investigator Head, Section on Pharmacology

Contributionu ere Dedoctible for Federat Irxone Tar Purpores

[PAGE 15]
9E3RET

INVOICE

For Services

\$26,GCG.00-

CRRTIPICATIONS

13 13

(1) It ie borcby ccrtifie&-tbat-thio 1s Invoice: -+3 sppiying to Sub-project No. of EXUrTRA  thnt perforcancé is satisfectory, that cervices ere bing eccocpliched in accordance vith Eutual egreerents, that e detailed egerês of the payeents and roceipto is on file in TsD/rs, that.this bill ia just ond correet and thst payeent therzof bas not yet been made.

Chief, Tso/Biologtcal Branch

Dete:3-April-1962

(2) It is hereby certified that this invoice ayolieo to Subproject of MUiinA vhich vao duly aproved, ani that the Projaot fa beihg carried out in cccoréance vith tho weñorandua of-13 Aonil 1953 fron the DI to tbz DD/A, a53 the exteñeion or this.autbority in subsequent meroronis.

Fesearch

Chief, TSD

[PAGE 16]
RECEIPT

Receipt is acknowledged of Treasurer's Check No. 190924, dated :

wE May 3, 1962, drawn on the

A in the amount of \$25, 000, 00, payable to B

Receipt is also acknowledged of Treasurer's-Check No. Y400026,

dated May 3, 1962, drawn on the

B

DArOrug, 8,,1962

[PAGE 17]
MEMORANDUM FOR: Chel, Flñance DIvislon

VIA:

TSD/Budget Olflcer

SUBJECTI

MKULTRA, SubproJect 47, Involce No. 13
Allotment No. 2125-1390-3902

1. Iavolce No. 13 covering the above subproject la attached. Payment ahould be made\_as\_follows

Cashier'a check In the amgunt of \$25, 000.00 Crawn on a erbank.

Cashler's check 1nAhe arount of \$1, 000.00 drawn on a bank. 2

Chocks should be toade payable tothe

2. Please forward the checks to Chlef, TSD/Blological Dranch through TSD/Budget Ofcer by 15 May 1962.

e 3. Thls ls a final Invoice. However, since it is anticipated. tbat adcitional funde will be obllgated for thls project, the filee should not be closed. 190924723000.00 Y40002.6- 1,000.00

Attached: Involce & Certificationt

24APR 1262
CRTTASAA
0012125-1390-3900

Distribution: Orig. & 2 - Acdreseco 1 - TSD/FASS 2 - TSD/BB TSD/BB:OA

47-13

23 Aprll 1962

[PAGE 18]
Date:12 April 962

METDRANDM FOR: The Coptroller

ATTEITION : Fimaõce Divisica SURiECrEURA, Subpojeet47

Unãer tha suthority granteć 1n tha emorassus cated 13 April 1953. frca the DCl to the D/A, eed tre extencion of this authority in sub-. sequent nénorenée, Subproject 47 hes been appreved end \$26,000.00 ct the over-sll Froject FuuinA fends reve bren obligeted to cover the rabpeojats copaser end chould be charged 1o cost ceater 2125-1390-3904

A

Chief, Tan/biolegtesl Brench

APF2OVED FOR OFLIOTON OF FUGPS:

Dicteiteticn: Crigircà  2 - Adéressce 1- TSD/FASS 1 - TSD/BB

CY DEDSAE ANAA 21251390-390 ALCR CIKE

C 47-14

KRTAST

[PAGE 19]
MKULTRA Subproject 47

1. The purpose ofthis subproject 47 is to provide funds to continue a research program bcing carried out by CarlC.-Pfeiffer, MD.

2. The nature of the invcstigations to be-carried out under the direction of Dr, Pfeiffer\_encompasses.pharmacological and clinical testing in aniinals and human volunteers of chemicals and biochemicals which alter behavior. Certain phases of other problems of interest toTSD will be . investigated.

3. Dr. Pfciffer is located at the New Jersey Ncuro-Psychiatric
Institute in the Bureau of Rcsearch in Neurology and Psychiatry, Princeton,
New Jersey. 2

4. The funds for this project will be transferred using the as a cut-out,

5. The cost of this program for a period of one year begiiuing 1 June 1962 will not exceed \$25, 000.00.To this swn must bc added \$1, 000.00 B representing a 4% scrvice chargc to tht , making the total amount \$26, 000.00. Charges should be made against Allotrnent No. 2125-1390-3902.

6. The New Jersey Mental Health Research and Development Fund

-SUBJECT:

47-15

DRAFT 12 April 1962

MEMORANDUM FOR:. THE RECORD

[PAGE 20]
with a summary accounting on an annual basis of all monies received from B
the They bave also agreed to return any unexpended funds B
to the as soon as possible upon the close of the grant year. 7. : The requirement for a six monthstinformal accqunting on the part
of the principal investigator is waived.

8. .Title to any permanent cquipment purchased by funds granted the New Jersey Neuro-Psychiatric-Institute.shall be retäined by the Institute in lieu of high overhead rates.

9. In connection with travel under this project, it is agreed that the - Agency will accept the travel documentation and accounting which conform. with the practices of the New Jersey Mental Health Reserch and Development Fund, Inc.

10. It is agreed that technical reports reflecting the progress of the research prograrn shall be submitted at mutually'acceptable intervals.

11. Dr. Pfeiffer has signed the Memoranduin of Agreement and holds a

TOP SECRET Agency Secvrity Approval.

APPROVED FOR OBLIGATION OF FUNDS:

Date: 23 APR 1962

Dornceed to: fefbniat ty /ohy of: 187475 cate:Jure 1977 E24E BY 187475

2

Distribution: Original only. Attachrnent: Proposal & Budget

dorssrezed yoy lyty outoril?ceté::77C57

[PAGE 21]
RESEARCH PROJECT APPLICATION

Grant Period June 1, 1962 through May 31, 1963

PROPCSAl: The tcsting in animals and humans of chemicals and biochemicals which altor behavior.

PLACE: Section on Pharmacology Bureau of Research in Neurology and Psychiatry New Jersey Neuro Psychiatric Institute Box 1000 Princeton, New Jersey

PRINCIPAL INVESTICATOR: Carl C. Pfeiffer, Ph.D., M.D.
CO-PRTNCIPAL INVESTIGATOR: CCEARTEM.D.

GRANP ADMINISTRATOR: New Jersey Mental Health Research and Development Fund," Ine. 1 Jil1 Lane, Trenton 8, New Jersey llenry P. David,Ph:D.Secretary-Treasurer

INTRODUCTION:

Our research efforts have received"local-attention and approbation during the past year so that we now have excellent rapport with the staffs of both the Institute and the'Bordentown Reformatory. We now have 10 volunteers per week from the -latter, and we have.a. Clinical Investigative Unit which will house 80"schizophrenics (present census 45 patients).

Current Status of the Pharmacology Unit

The laboratory is still undergoing minor construction, but material progress has been made in the past year.The section for animal screening and conditioning is complete. The sections for animal neuropharmacology and clinical pharnacology have been constructed and put into operation, andan electronic workshop has been set vp. All these units are actively at work in human and animal experiments as outlined below. The facilities

WARNINGNOTICE SENSITIVEANTZLLICENCE SCURCESANDMETHGDS INIOLVED

47-16

[PAGE 22]
of tho clinical unit---experimental ward---are nearing completion, and are already in partial use. Still in varying stages of construction are the biochemical pharmacology and medicinal cheuistry units.

Personnel: Since the last report, the section has been joined by Drs. and as planned. It is anticipated that two to thrce more. investigators at the doctoral level will be nceded, probably one more clinical pharmacologist, a medicinal chemist, and a biochemical pharmacologist.Two engineers have been employed for design and construction of new equipment and six lab assistants are now-fully trained to their various. jobs.

Human subjects: Liaison with New Jersey-State Reformatory- Bordentown has becn excellent, and a full complement of volunteers from that institution has been freely available.This group may be a better group for this kind of research, since they may be closer to the normal population than were the Atlanta prisoners, the latter being recidivists and older than the Bordontown' group. In addition, other hunan volunteers have been recruited, including female subjects, so that the population of "nornal" subjects available is now much more nearly representative of the population at large. In addition;-it has been possible alrcady to begin explorations with the psychotic patients fron the experimental ward, and sone interesting results are already forthcoming (see below). Equipment: Since the last report,-the section has obtained a stereotaxic apparatus, a Grass Model III EFG, and a Sanborn 2000 magnetic tape Data Recorder. In addition, we have constructed two new integrators for quantitative EEG; these are modeled after the Drohocki Integratör; but due to some circuit changes are more linear, and have the advantage of using all USA-made parts, so that maintenance is simplified. Two more integrators are under construction which will alow simultaneous

WAXNING SENSITIVE INTSLUICENCE SOURCEA AXS METIRONS INVOLVED

[PAGE 23]
integration of four leads, one from each lobe of a hemicranium, Also under. construction is a quantitative spectral analyzer for use with the tape recorder in analyzing scalp ErG of humans as well as electrical measurements from implanted electrodos in cortex and deeper structures in brains of animals. Data will be entered on punch cards and processed by a digital computer. Target date for beginning calibration and standardization is June 1, 1962. These new approaches allow determination with great accuracy of effects of various classes of compounds and the interactions of such agents.

A Barber Colman gas chromatograph has been installed and a technician is being traincd to operate it. This makes-possible correlative studies of changes in brain constituents, changes in behavioral state, and electrophysiological data. This method is far more sensitive than previous techniques, and allows accurate measurements to be made from much smaller brain fractions. A Beckman pli meter and microburette have also been obtained for study of cholinesterase activity,-since it appears that psychotonimetic effects frequently if not always involvē atropine-like drug action (Pfeiffer, C.C.,-et al. Neurology, 9: 249-250, 1959) Recent and currént projects: These new techniques, together with the unique availability of human-subjects both normal-and abnornal, make possible a wide range of investigations on ny class of conpounds with action on the central nervous system. These can begin at the most basic level and move progressively to a level of sophistication beyond that of alsost any other setting. Sore idea of the directions currently being taken are indicated in recent and current work. Enclosed are-reprints of publications during the past year. The following are also accepted for C publication and. will appear in the next few months:

SENC fu12 SCUACES METUOZS INVCAVED

[PAGE 24]
and Pfoiffer, C.C. Use of normal subjects for testing drugs (Upjohn Conference), Clin. Pharmacol & Therap. At the Federation mcetings in Ao this month,e will report on, and r and Pfeiffer will report on, Quantitative electroencephalographic analysis of the effects of lysergic acid diethylamide (ISD-25 and d-aimphetamine in man. At and in Munich Dr. Pfeiffer is giving a paper on, Further Quantitative electroencophalographic studies of the stimulant effects of deanol and d-amphetamine in man. Abstracts of these four papers are enclosed.

In addition to the above, which are ready for formal presentation, the following are under\_way:A number of tryptamine derivatives are being explored for psychotomimetic and other.effects; 4-hydroxy-a-methyl tryptamine, 4-męthyl-a-methyl tryptamine, 6-hydroxy-N,N-dimethyltryptamine (The di-methyl analogue of Szara's-compound), prolyltryptamine, psylocin, and acetyl tryptamine. Results will be reported as they accrue, The central actions of y-aminobutyric acid are being indirectly explored by jnvestigating y-butyrolactone and y-hydroxybutyric acid. Unlike GABA, these compounds readily cross the blood-brain barrier, and the:latter is a potent hypnotic agent and about as active and positive as is chloral hydrate has reported an abnormal EEć response to intravenous thiobarbiturate in schizophrenics. Our quantitative method -shows no difference as yet in response between normals and schizophrenics. to the intravenous injection of thiopeutal.

WARNI SERSITIVE EHIELLICENCE SOURCES ND MATHOOS INVOLVED

[PAGE 25]
In the light of the above, the following are planned for the coming year:

1... Screening of tryptamine compounds in animals and man for hallucinogenic action.

2. Completion of the study of the use of riboflavin as a trace chemical to prove the ingestion of medication in a clinical setting.

3. Further studies on the use of phenoxybenzamine and other aorenergic blocking compounds ás antidotes to-LSD-25.

4. Further refinement of the use of quantitative brain wave studies to diagnose schizophrenia and to determine the action of hallucinogens.

S. Selection of one or more of a series of stimulant diamines for chronic toxicity studies in animals so that they can be tested in normal human voluntecrs for possible stimulant action.

6. A search in brain extracts of rabbits treated with Tofranil (imipramine) to determine if any stimulant-amineaccwnulates as a result of degradation of the drug molecule in the body.

7. Determination of the anti-cholinesterase and aminoxidase inhibitory effect of the stimulant diamines.

8. Assay of acetyhholine content of various portions of the brain after prolonged dministration of deanol.

9. The assay in man of an intravenous analgesic solution composed of morphine and choline or morphine and carnitine wherein the pharmacologically neutral quaternary compound prevents the engagement of peripheral receptors by the morphine.

O

5.

WARNING NOTICESENSITIVE INTEVLIGENCSOURCES AD METIOOSNVOLVED

C

Research Proposals

[PAGE 26]
10. The use. of stimulants to prevent the blocking of conditioned behavior.

Ji. The use of parasympathetic stimulants and methylatropine to interrupt trained behavior.

12.. A study of praetical drug antidotes to atropine-like compounds.

13. Careful study in norsial man of B B. Compounds supplied by the r C. Biochemicals purchased

Note: For elaboration of methods see the 196l-1962 proposal.

WARNING VOTCE SESSITIVE AATELLIGETICE SOURCESNNO METHODS INVOLVED

[PAGE 27]
Research Project Application - Pfeiffer and urt

June,1, 1962 through Hay 31, 1963

In lieu of overhead, the New Jersey Mental Health Research and Development Fund, Inc. will retain title to any equipment which may be purchased under said grant.

WARNING NOTICE SEISITIVE INTELLIGENCE SOURCES AND METHOCS INVOLVED

[PAGE 28]
March 2, 1962

Dear eta

Attached you will find interim report of our expenditures from the cz from the period beginning June 1, 1961 and ending May 31, 1962.

This brings to mind your promised trip. to see our laboratory and the progress in our research efforts. We hope that the month of March will afford you time for such a visit since we now rave much to show you.

With best regards,

Yours sincerely,

CCP:mc

Att.(1)

Carl C. Pfeifler, .D Head, Section on Pharmacology

C 47-17

0

State of New Yersey

JOSEPH M. TOBIN, M.D. DIRECTOR

BUREAU OF RESEARCH IN NEUROLOGY AND PSYCHIATRY C/O NEW JERSEY NEURO-PSYCHIATRIC INSTITUTE BOX 1000 PRINCETON, NEW JERSEY 4

[PAGE 29]
Period Ending Marcì 1, 1962

47-

[PAGE 30]
Dear

Atzched you will find intepim report of oue expenditures irsa th grant from the period beginning June 1, 1961 and-ending-May-31,1962.

This-briogs to aind your-pronised trip to see our laboratory suà the prcqress in our research efforts.We hope that: the acath of March will afford-you time for such a visit since we now have much to show you:

With best regards,

Yours sincerely,

CCP:mc Att."(1)

Carl C. Pfeiffer, .D Head, Section on Phaomacology

47-17

State of New Jersey

BUREAU OF RESEARCH IN NEUROLOGY AND PSYCHIATRY C/O NEW JERSEY NEURO.PSYCHIATRIC INSTITUTE BOX 1000. PRINCETON, NEW JERSEY

JOSEPH M. TOBIN, M.D. DIAECTOR

March2, 1962

[PAGE 31]
Period Ending March 1, 1962

B

[PAGE 32]
NEW JERSEY MENTAL HEALTH RESEARCH AND DEVELOPMENT FUNO, INC.

Trustees

JOSEPH M. TOBIN, M. D., Chairman • PAUL HAUN, M.D, Vicé Chairsn "HFNRY P. DAVID, PH.D, Seerery Treuror V. TERRELL DAVIS, M.D. • MAURICE G. KOTT, PH.D. • DOUGLAS H. MACNEIL • LLOYD W. MCCORKLE, PH. D.

October 21, 1961

Addres Correspondence to; Henry P. David, Ph. D. Secretary Tressurer 1 Jill Lene Trenton 8, N. J.

Deer Dr. C

It i3 with pleasure that I'acknowledge your rccent contribution of \$15,370.00 as the first payment on the-new grent under\_Dr.Cerl Pfeiffer.

Yours sincerely,

hPDaud

Henry P. David, Ph.D. Secretary-Treasurer

HPD:of cc: Dr. Carl Pfeiffer

47-18

Contributions are Deductibte for Federal Ircore Tar Purposes

[PAGE 33]
RECEIPT

Receipt is hereby acknovledged of the following two cbecks:

Treasurer's Check No. 184354, dated July 26, 1961, drawn on the ns, in the eoount of \$1,229.60, payable to the

Treasurers Check No. 267969, dated July 26, 1961, drawn on the in the amount of \$30,740.00, payable to the

3074, 6122960 3156FC

47-19

[PAGE 34]
June 1, 1960 to May 31, 1901 , ,

with New Jersey Nental Health Rcsearch and Development Fund as the Recipient

Fypenditures

ce. Joseph M. Tobin, Director, Bureau of Research David Henry, Sec. Treas.,-lewJersey Kental Health Research and Development Fynd

Bark . Clerig  D.

47-20

[PAGE 35]
Dr
Diroctor B

Dear Dr.

It is a plcasure to acknowlodge receipt of your check in the amount of twolve thousand three hundred seventy four dollars and fifty cents (\$12,374.50), ropresenting the' fourth quarterly paypent supporting the research progran of Dr. Carl C..Pfeiffor.

Yours sincorely,

IP. Danid

HenryP.David, Ph.D. Secretary-Treasurer

HPD/1m CC: Dr. Carl C. Pfoiffor Dr. Joseph Tobin

47-21

NEW JERSEY MENTAL HEALTH RESEARCH AND DEVELOPMENT FUND, INC,

Trustees

JOSEPH M. TOBIN, M.D. Chairman• PAUL HAUN, M.D, Vice Chairman • HENRY P. DAVID. PH.D, Secretary Trésrurer V. TERRELL DAVIS, M.D, • MAURICE G. KOTT, PR. D. • DOUGLAS H. MÁCNEIL  LLOYD W. MCCORKLE, PRD.

Addres Correspondence to: Heary P. Devid, Ph. D. Secretary Tressurer 1 Jilt Lane Trenton 8, N. J.

May 12, 1961

Contritostions are Drductible lor Frderel Incore Tar Purposer

[PAGE 36]
2. Pleaso fozwazd tho chöeka to Chiēf, TSD/Revearch Branch throagh SD/Bedget Ciüicer by 24 Jüly 1961. 3. Tois is e Real lävolce. Howevor, sinco It fa anticipated that sdsitiocal Suids will be obligatsd for thia project, the filer shoold not bo closed.

Chief TSD/Research Branch

Altached: :. Involce t Cortificationa

Diotribution: Orig u'2 - Adrosp0o

1-TSD/FASS .2-TSD/RB

TSD/RB:(A)

[PAGE 37]
CERTIFICATIONS.

(1) It 1s herby certiried thst this is Iavoice l2 epplying to sub-project No. 4f of láULTRA, that perforzence is satisfactory, that services are being accoplished in accordance vith mutval egreerents, that a deteiled agenda of the paymcnts End receipts is on file in TSo/RB, that this bill-1e just and correct snd thet peytent thereof bas not yet teen nade.

Chief, TSD/Research Branch

Date:

(2) It. 1s hereby certiried that this invoicc 6pplies to Sub?roject of MULiRA vhich vas duly epproved, and that the proJect is teing carried out in accordence vith the meaorandua of 13 April-1953 froa the DCI to. the DD/A, and the exteucion of this authority in subscquent cecorenda.

Rebcarch Director

For Services

C

47-2-2

SECRET

INVOICE

\$31,969.60

SECRST

[PAGE 38]
Cost Account d/32. 1391- 3902

Object Class

SECRET (Whe&Ferd In)

O

SACREN (When Filled In)

47-23

No..117

[PAGE 39]
MEMORANDUM FORI COMPTROLLER

FInance Division ATTENTION MKULTRA, Subproject 47, Add{tlonal SUBJECT Authorlzation No. 9

Under the authorlty granted ta the memorandum dated 13 Aprll 1953 from the DCI to the DD/A, and the extenslon of tbis authorlty In subsequent memoranda, Subproject 47 has been approved and \$31, 969.60 of the over-all MKULTRA project funds has been obligated to cover the subproject expenses. This obligatlon of funds should be charged to Allotment 21z5-1390-3902.

Chtef, — TSD/Research Branch

APPROYED FOR OBLIGATION OF FUNDS:

A Research Director

LCESTY THAT ROS ARE AVARABIL AN 10 2151503 AUTHORTNG ORFICER

121

Date:

plstributlon: Orig & 2 - Addressee 1- TSD/OC 1TSD/FASS 2 - TSD/RB

SEPET47-24

1June 1981

SEREL

[PAGE 40]
SUBJECT: The Testing In Anlmals and Human Volunteers of Chemfcals and Blochemicals Which Alter Behavlor.

The New Jersey Neuro-Psychiatric Institute The Burcau,of Research In Neurology and Psychíatry Princeton, New Jersey (P.O. Box 1, 000)

PRINCIPAL, INVESTIGATOR: CarI C. Pfeiffer,Ph,D., M.D.

GRANT ADMINISTRATORS: New Jersey Mental Health Research and Development Fund, Inc. 1 Jill Lane, Trenton 8, New Jersey Henry-P, David, Ph.D., Secretary-Treasurer

It Is proposed to conduct screening and range finding tests on volunteers with chemlcat compounds of known behavloral activity.: Studles will be conducted on derivatives of selected biologlcally active compounds to determine thelr actlon on the central nervous system of man.

In addition to these invesligatlons, the following work will be undertaken;

1. Pharmacological testing will be conducted on animals utilizing candidate halluclnogenic chéroicals.

2. Stüdies will be conducted on cotnpounds of relativly slmple" configuratlon to assess their ability to tnhlblt trained behavior In animals utllizing the condition avoldance responses.

3. Studles will be conducted of compounds In normal human volunteers for possible behavloral changes utillzing compounds provided by the sponsor..

4. Quantitattve studtes of the EEG In anirnals and man to determine stlmulant or depressant effects of candidate materfals.

PROPOSAL

[PAGE 42]
SUBJECT

i MKULTRA,-SubproJect 47, Invoico No. 12 A11otment 2125-1390-3902

1. Involce No. 12 covering tho above subproject is attached. Payment should be made as tollows!

Cashler's check In the amount of \$30,740, 00 drawn on a E wenaougR,bank.

Casbier'e chcck1n tho amount of \$1, 229. 60 drawn oa a E crbank R

Chccks ehould be inado payablo to the

2.. Please forward the checke to Chtcl,:TSD/Research Branch through TSD/Budget Ofcer by 24 July 1961.

3. This is a final invoico. However, clnco it is anticipated that additlonal funds will be obllgated for thle project, the files should not bo closod.

A
Chief
TSD/Reecarch Branch

Attachedt Involce & CertificaHons

Distrlbutlon: Orig & 2 - Addressce

47-27

12 July 1961

MEMORANDUM FOR: Chef, Fnance DIvIston

VIA

: TSD/Büdget Offcer

[PAGE 44]
MEMORANDUM FOR:- Chief, Floance DivIsion.

: TSD/Budget Olcer

SUBJECT

MKULTRA, Subproject 60, Involce No. 7
A1lotment 2125-1390-3902

1. Invoice No. 7 In the amount of \$18, 500 1e attached. However, due to refunds of \$5,58z, 12 froin this and one other project (as per attachments) payment should be uade as followá:

Cashier's Check In the ainount of \$12, 917. 88, drawn on 4 local bank, payable to the Soclety for tho Investigation of Humian Ecology, Ine

2. The checks should be forwarded to Chief, TSD/Research Branch, through TSD/Budget Officer, no later than Monday, 8-May1y6t.

3. This ls\_a final lnvoice." However, since it is anticipated that additional funds will be obligated for thls project the files should not be clósod.

A Chlet TSD/Research Branch

Attachment: Involce & Certificatlons

Distribution: Orig & 2 - Addressee

7596

47-29

26 Apr11 1961

[PAGE 45]
The Testlng in Animals and Human Volunteers of Chemfcals SUBJECT: and Blocheintcals Which Alter Behavior.,

PLACE:

The New Jersey Neuro-Psychiatric Institute The Bureau of Research in Neurology and Psychlatry Princeton, New Jersey (P.O. Box 1, 000)

PRINCIPAL 1NVESTIGATOR:CarUC. Ple{ffer, Ph,D., M.D.

GRANT ADMINISTRATORS: New Jersey Mental Health Research and Developinent Fund, Inc. I Jill Lane, Trenton 3, New Jersey Henry P. David, Ph.D., Secretary-Treasurer

It is proposed to\_conduct sereening and range finding tests on volunteers with chemical compounds of known behavtoral activity. Studles will be conducted on derivatives of selected blologlcally active compounds to determine their aclfon on the central nervous syster of man.

In additlon to these Investlgations, the following work will be underlaken:

1. Pharmacological testing wlll be conducted on aníinals ulilizing candidate hallucinogenic chemicpls.

2. Studies will be conducted on compounds of relativly simple configuration to asscss their abillty to inhibit trained behavior in animats utllizing the condition avoidance responses.

3. Studies will be conducted of compounds in normal human volunteers for possible behavloral changes utilizing compounds provided by the sponsor.

4. Quantitatlve studles of the EEG in anlmnals and man to determine sttmulant or depressant effects of candidate inaterlals.

47-30

PROPOSAL

[PAGE 46]
1. The purpose of thlș subproject 47 is to provide funds to continue a research program being carried out by Carl C. Pfeiffer, MD.

2. The nature of the investigations to be carried out under the direction of Dr. Pfeiffer encompasses pharmacological and clinical testing in antmals and human volünteers of chemicals and biochemicals which alter behavior. Certain phases of other problems of interest to TSD will be Investigated.-

3. Dr. Pfeiffer is located at the New Jersey Neuro-Psychiatric-Institute in the Bureau of Research in Neurology and Psychiatry, Princeton, New Jersey. B

4. The funds for this project will be transferred using the as a cut-out.

5. The cost of this prograrn for a period of one year beginning 1 June 1961 will not excced \$30, 740.00. To this sum inust be added \$1,229.60 B representing a 4% service charge to the making the total arnount \$31, 969,60. Charges should be made against Allotment /2125-1390-3902.

6. The New Jersey Mental Health Researchand Developinent Fund Ine., who administer the grant have agrced to provide theytos 3witha summary accounting on an annual basis of all monies recelved C CORDEATAL de: 227415 HUE SLUET

SUBJECT

Dewcrzed tC0PqTl xyariy [18/475] cetof Jurd 1777 E2 1S2T: CL BY(197475

DRAFT 1 June 1961

47-31

MEMORANDUM FOR: THE RECORD

: MKULTRA Subproject 47

[PAGE 47]
E2 10ET:CL BY,1874 from the They have also agrced to return any urexpended B funds to the as soon as possible upon ihe close of the grant year.

7. The requirement for a six months' informal accounting on the part of the principal investigator is waived.

8. ¿Title to any permançnt equipment purchased by funds granted the New Jersey Neuro-Psychiatric Institute shall be retained by the Institute in lieu of high overhead rates.)

9. In connection with travel under this project, it is agrced that the Agency will accept the travel documentation and accounting which conform with the practices of the New Jersey Mental llealth Research and Development Fund Inc.

10. It is agreed that technical reports reflecting the progress of the research program shall be submitted at mutually acceptable intervals...

11. Dr. Pfelffer has signed the Memorandurn of Agreement and holds a TOP SECRET Agency Secvrity Approval, 1

APPROVED FOR OBLIGATION OF FUNDS:

Date:

Attachments: Proposal & Budget

Distribution: Original Only

10: A /CL B7 137475

[PAGE 48]
The Testing in Animnals and Human Volunteers of Chemicals SUBJECT: and Biochemicals Which Alter Behavior.

The New Jersey Neuro-Psychiatric Institute The Bureau of Re'search in Neürology and Psychiatry Princeton, New Jersey (P.O. Box 1, 000)

PRINCIPAL,INVESTIGATOR:CarI C. Pleiffer,Ph.D., M, D.

New Jersey Mental Health Research and GRANT ADMINISTRATORS: Developnent Fund, Ine. 1 Jill Lane, Trenton 8, New Jersey Henry P, David, Ph.D., Secretary-Treasurer

It is proposed to conduct screening and range finding tests on volunteers
with chemical compounds of known behavloral activity. Studies will be
conducted on derivatives of selected biologically active compounds to deter
mine their action on the central nervous system of man. 10 ten …-da-toten!

In addition to these Investigations, the fōllowing work will be undertaken: n1

1. Pharmacological testing will be conducted on aniınals utillzing candidate hallucinogenic chemicals.

2. Studies will be conducted on compounds of relativly simple configuration to assess their ability to inhibit trained behavior in animals utilizing the condition avoidance responses.

3. Studies will be conducted of compovnds In normal hurnan voļunteers for possible behavioral changes utilizing compounds. provided by the sponsor.

4. Quantitative studies of the EEG in animals and inan to determine stimulant or depressant effects of candidate materials.

0

47-31

PROPOSAL

WARNING ROTICE SENSITIVE INTELLICENCE SOURCES AND METHORS INVOLVED

[PAGE 49]
Requested Budget June 1, 1961 thru May 31, 1962

In lieu of overhead, the New Jersey Hental Health Research & Developnent Fund will retain title to any equipaent which may be purchased under said grant.

-Pfeiffer Research Projéct Applicatón

47-31

5/61

WARNINGNOTICE SENSITIVE ANTELLIGEXCE SOUREES AND METHODSINVOL

[PAGE 50]
RECEIPT

Receipt is hereby acknowledged of the following two checks: Reccipt is nerc " 1okn. drawn on

Ófficiat Check No.G42787; dated July 7, 1960, drawn on or in the amount of B
\$49,498.00, payable to the ..1960. drawa on

Official Check No. G42786, dated July 7, 1960, drawa on st, ia the amount of E \$1, 979.92, payable to the

47-32

[PAGE 51]
MEMORANDUM FOR: CHIEF, FINANCE DIVISION

VIA

:TSD/Budget Officer

SUBJECT

: MKUI,TRA, Subproject 47, Iavolce fll Al1otment 0525-1009-4902

1. Iovoice fll coverlog tbe above subprojoct Is attached. Paynuent hould be made as followe: ∴

Caohler's check ln the amount of \$49.498.00, drawa E on a dasataa.

Cashler'e ichock In the amount ol \$1, 979.92, drawn

Fach check should be mado payable to thodi

2. Please forward the checks to Chlef, TSD/Rescarch Branch througb TSD/Budget Oflicer by 13 July 1960.

3. Tbis lo a flnal lavolce. However, tinçeIt le anticlpated that additlonal fundo will be obllgated for this project, the filee should not bo closed.

Chlet TSD/ReBtarch Braoch

Attachmeot; Involce & Certificatlons

Distributlon: Orig & 2 - Addrcspce\_

1:TSD/FASS 2-TSD/QB

SECRET

Y

47-33

29 Ju0e 1960

[PAGE 52]
CERTIFICATIONS

(1) It is hereby certifled that thie Is Iovoice fll applylng to Subproject 47 of MKULTRA, that perforrnance Is eatisfactory,-that servIces are being accomplisbed In accordance with mutual agreements, that a detailed agenda of the payments and recelpts le on file ln TSD/RB that thls bill le juet and correct and that payment thereol bas not yet becq made,

Chlef. TSD/Reaearch Branch

Date:

(2) It is hereby certifled that thla lovolce applies to Subproject No. 47 of MKUI,TRA which wae duly approved, and that the project-Is belog carrled out In accordance with the meinoranduin of 13 April l953 from the DCI to the DD/A, and the extonalon ofthls authority lo subscquent mnemoranda.

47-33

INVOICE

\$51,477.92

[PAGE 53]
1. The purpose of this subproject is to provide funds to continue

a research progran being carried out by Carl C. Pfeiffer, M. D.

2. The nature of the investigations to be carried out under

the direction of Dr. Pfeiffor encompasses pharinacological and

clinical testing in animals and human volunteers of chemicals and

biochemicals which alter behavior as outlined in the attached proposal.

3. Dz. Freiffer was previously-located at the Einory Uoiversity.

Atlanta, Georgia. Heis now located at the New Jersey.Neuro-Psychiatric-

Inetitute in the Bereau of Research in Neurology aod Psychiatry, Princeton,

New Jersey. This change-in position will oot io any way interfere with the

Ageucy sponsored work, in fact; Dr. Pfeiffer will have access to more

and better equipinent and personnel for his research.

4. The funds for this project will be transferred using the

B crs 2s 2 cut-out.

5. The cost of this program for a period of one year beginning

1 Jun= 1960 will nct exceed \$49,498.00. To this suin rnust be added

\$1,979.92 representing a 4% service charge to theB

s to:9 1.0:113 9f: 187477 1077 1ETCIBY 187475

Duitr aytority or A5/475 Jhe 377 YPDET cj BY 107475

DRAFT 20 May 1960

SUEJECT

MEMORANDUM FOR: THE RECORD

: MKULTR.A, Subproject 47

[PAGE 54]
makiog the total amount \$51, 477,92. Charges should be made against Allotment 0525-1009.4902. 1 2

6. The Karhas requested The New Jersey

Mentel Heaith Research and Development Sund, Inc., who administer the grant, to submit to tbem a summary accounting en an acnual basis of all monies received from the Fuod. Also, it has been requested that acy unexperded funds be returoed as soon as possible upon tbe close of the grant year.

7. The requirement for a six moaths' informal accounting oo the part of the principal iovestigator is waived.

8. Title to any permanent equipment purchased by funds granted the University shall be-retained by the University in lieu of high overhead rates..

9. Ia connectioc with travel under-this project, it is egreed that the Ageocy will accept the travel documentation and accounting which conform with the practices of the Uaiversity.

10. It is agreed that technical reports reflectiog the progrgas of the research program shall be submitted at mutually acceptable intervals.

Sacrzued 4 127475 7 eor te J/1977 2I C BY 157475

foced yor gONEIGEENAL oth 17475 127 C 187475

[PAGE 55]
by e1z0r127 df1107479
catg: Jeé 19f7
中
E2Dz5T; ck  18745
11. 1

and holds a TOP SECRET Ageocy Security Approval.

Chief TSD/Chemical Branch

APPROVED SOR OBLIGATION OF FUNDS:

Attachmeot: Proposal & Budget

Distributioo: Original onty.

Dere to. LOAL ty 00=1tycl: 151475 (ato: ne 1377 12 17: 1 187475

[PAGE 56]
PRoposAl: The testing in ahinals and human volunteers of chemicals and biochenicals which alter behavior.

PLAcE: The New Jersey Neuro-Psychiatric\_Institute The Bureau of Research in Neurology and Psychiatry Princeton, New Jersey-(P. 0. Box 1,000)

PRINCIPAL INVESTIGATOR: CarI C. Pfeiffer, Ph.O., M.O.

GRANT ANMINISTRATORS: New Jersey Mental Health Research and Development Fund, Inc. I Jill Lane, Trenton 8, New Jersey Hanru P Nad DL n

INTROouCTION: The has aided the rescarch studies of the principal investigator for more than ten years, during which time many notable advances have been accomplished. Ep C

At present the s supports the search for new hallucinogens (chenically simpler than LSD-25). These are synthesized by-saacx tested in animals and in vitro systens and then cautiously tested in man. "kss is taking a leave of absence next year and wili work in l9sl as head of medicinal chenistry in the wevitilaI LhenlsLry in tne

B 1951, and in lgs0-1951 we wil1 test the backlog of conpounds already synthesized. The grant to Eaory will terminate as of May 3l, 1950, which is the close of the present grant year. Other funds are available at Emory to continue the testing of the  conpounds at the Atlanta Fcderal Penitentiary under the direction of
C.Mee, M.0. fron the period June 1. to December 31. 1950. Ru C M.0. fron the period June 1, to Jecember 31, 1950. By

this time the huran testing will-be-organized and progressing in New Jersey under the direction of the principal investigator. On July 1, -1951 will B have completed his.last six months of a split interoship and will join the research team in the New Jersey location.

RESEARCH PROPOSALS:

A. Pharmacological testing in animals of candidate hallucinogenic chemicals.

B. Study-of simple compounds which may inhibit trained behavior such as the conditioned avoidanice response.

C. Careful study of conpounds in normal humanvolunteers for possible behavioral changes: C.

1) synthesized coapounds

2) Conpounds supplied by  B

3) siochenicals purchesed

WARRING NATICE SEUSIIVE INTCLLGENCE CRCES ANO NETHOOS INVOLVED

47-34

RESEARCH PROJECT-APPLICATION

[PAGE 57]
D. Quantitative studies of the EEG in animals and man to determine stimulant or depressant effects.

E.Annual conference on the ncuro-biology of psychoses.

Proposals A, 8, and C are a continuation of the work now in progress which is familiar to the officers of The rcer fron our annual and semiannual reports. Under C the'source of hunan voluntcers will be the l00 refornatory inmates (agcs 18 to 28) who àre stationed on the grounds of the Institute. If 16 volunteers, aged 21 to 28; are not obtained fron this group for a weckly session of drug testing, we will have one session of eight-subjects at the Institute and one session at the New Jersey·State Prison in Trenton."Comissioner Bramberg has given his penmission.

Under D we now have perfected and plan to use at the New Jersey Laboratory a quantitative integrator for drug studies\_in both man and animals.

Adult unanesthetized, trained animals are used. Under anesthesia small goldplated wood screws are used as dural clectrodes. These are lightly engaged in the calvariun ond held firmly in place with methacrylate with the permanent lead. attached. The recording leads are bi-polar from the left and right frontoparietal lobes of the brain. The animals are in a sound attenuating box and sit quietly for the entire 1 to 2 hour session after a-few training periods.

A Crohocki integrator is attached to one lead. This device rectifies the brain waves and by a chopping process, counts the area under the rectified curve. A signal is made at a pre-set degtee of sensitivity. The nunter of signals per unit time is a measure of the degree of-clectrical activity or ."electrogenesis." The number of pulses or signals is directly correlatoble with the arca under the curve. The constancy of the electrogenesis with elapsed time can be calculated and treated by the usual statistical methods.In this type of-analysis, periods as long as five minutes can be used as a baseline or control and thus transient artefacts are eliminated. The action of drugs is usually mcasured at l-5 minute intervals after intravenous injection and the drugaction is expressed as change in percentage electrogenesis fran the control preinjection period. Arousal or stjinulant drug effects are recorded as a decréase while sleep (sine waves) produce an increase. in electrogenesis.

ε. Annual conference on neurobiology of psychoses. Host previous conferences of this type have been poorly plonned, ond the sroup has been too large and unwieldy. Money spent on verbatim recording and publishing is wasted, end this process further inhibits the participants.

The participants will be limited to 12 or 15. The record will be in the form of the individual's own notes and the notes of a.scientifically trained secretary. The sumnarizing secretary will chonge with each threc-hour session, In a two-day conference we would have five sessions of three hours cach.

The conference would be held int just tefore or after'the hOnly
scientists with a biological approach to mental disease would Le invited. The
various basic disciplines would be reprcsented. Sane of the participants might be

(47-34

Research Project Application -Pfeiffer

page 2

WARNING/NOTICE SENS TIVE NTELLIGENCE SOURCES ANDHETHOOS INVOLVED

[PAGE 58]
Prior-to the meeting a questionnaire on possible biotogical factors in mental
disease would be circulated to the participants, and their response to these possible
etiological factors listed would determine the agenda and the priority of the factors t-\~ are for:

discussed. Possible biological factors which will be included in the questionnaire are for:

A. The Schizophrenias (assuming a heterogeneous clinical entity) The Schizophrenias (assuming a neteroycuc

1 Defective keto-acid utilization
2) Defcctive carbohydrate utilization
3) Decreased level ofblood glutathione
56か8 Therapeutic effect of intravenous glutathione Increased ascorbic acid requirement Incrcased ceruloplasmin in acute schizophrenia Therapeutic effect of ceruloplasmin The effect and role of Taraxein
9) Increased adrcnal cortical and medullary. activity
10) Increased urinary catechol anine excretion
11) Increased urinary indole excretion-
12) Epinephrine metabolism
13) Serotonin
14) 15) Thyroid function Estrogen-androgen function (more comon in feaale?)
16) Liver function tests Co-enzyme activity (hippuric acid synthesis) Co-enzyme A
17)
18) Effect of growth hormone a) Qccurs when sonatic growth stops b) Post-partum psychosis c) ACTH psychoses
19) Childhood autism and the adult schizophrenics
20) Pineal gland extracts
21) The schizophrenias in the blind
22) Sensory deprivations and psychosis
23) EEG abnormalities a) Heath's septal spikes b) 14 and 6 disorder Biology of electroconvulsive therapy (change in cholesterol e: c) Goldman's fast activity after pentothal
24)
25) Biology of insulin coma therapy
26) Specific effects of nicotinic acid therapy
27) Specific effects of phenothiazines
28) Specific effects of reserpine
29) Specific effects of deanol
30) Porphyrin metabolism 31) Thioctic acid 32) funkerstein tests 33) Response to histamine and allergies 34) Overdosagc of amine oxidase inhibitors 35) Influence of tuberculosis, influenza, etc. 36 Somatotypes

Research Project Application - Pfeiffer

page 3

SOURCES AND METHOOS INVOLVED

[PAGE 59]
B J Research Project Application - Pfeiffer

47-34

B. Depressive psychoses

1) Amine oxidase inhibition 1) Amine oxidase innivitivu

2) Action of electroconvulsive,therapy or insulin

3) Deanol therapy 351

4) Blood butane-2, 3-diol levels

5) Sonatotypes

C. Manic psychoses

1) Effect of lithiun

2) Metabolism of uric ącid-

3) Hyperthyroid mania 15

Neuraminic acid 41

5) Catechol amine excretion

6 Indole excretion

7 Bloodacetoin levels

8) Effect of phenothiazines

9) Sonatotypes

page 4

WARNINSNOTCE SENSITIVE ANTELLICENCE SOURCES DMETROS IVOLVED

[PAGE 60]
In lieu of overhcsd the Nev Jersey Hental Health Research and Development Fund will retain title to all permanent equipnent purchased under said grent..

The above grant is requested for the period June 1,-1S50 through Hay 31, 1951.

Research Project Application - Pfciffer

C 47-34 page 5

BUDGET

WARNING NOTICESENSITIVEANTLLIGENCSOURCES AND METHODS K:OVED

[PAGE 61]
MEMORANDUM FOR: COMPTROLLER

ATTENTION

: Finance Divlelon

SUBJECT

: MKULTRA, Subproject 47, Additlonal Authorisation No. 8

Under the authorlty granted la tho premorandum dated

13 Aprll 1953 froin the DCi to the DD/A, and the exteaslon of thie

authority In sudsequent inemoranda, Subproject 47 bas been

approved and \$51,477.92 of the over-all MKULTRA project lunds

hao been obligaled to cover the subproject expenies. Thie

obligatlon of funds should be charged to Allotinent 0525-1009-4902.

Chiel TSD/Chemlcal Braoch

APPROVED FOR OBLIGATION OF FUNDS:

Rescarch Director

Cate:

Dletrlbotlon: Orig & 2 - Addressee.

1.TSD/OC

1 - TSD/FASS

2-TSD/CB

TSD/CB/

47-35

20 May 1960

SECRET

[PAGE 62]
Departcent of Phanacoloy

Dr. Cerl C. Freirfer, Director

Su-ary of Receiots end Rcenditures for the Period

June 1, 1959 tmou h 1av 31, 1050

Received froa 1959-60

\$16,377.50

\*DIRECT EXPEDITUREST

Personnel \$23,359.39
Fellowships 7,300.00
Fuan Subjects 3,310.00
Travel 2,919.36
Bouirzent 1,005.68
Ependable Supclies 2,773.99
Totel Direct Npenditures \$43,668.42
Inüirect Costs 4,355.84
TOTAL EXPADITURES \$48,035.26

\*See attached schedules

I have exanined ord cryeeved the sudattted expeniitarcs.

47-36

C

BORY UIVERSITY

TS/Cheztcl Divtsion

[PAGE 64]
TRAVL

EORY UNIVERSITY

47-34

B

Department of Phar acology

Dr. Carl C. Pfeiffer, Director

[PAGE 66]
FUDRY UNIVERSITY

47-36

Derartment of Fharmecoloay Dr. Carl C. Ffeiffer, Director

SUPPLIES

(continued on pege 2)

[PAGE 67]
47-36(rase 2)

[PAGE 69]
A Dearme;

Attached you will find our research proposal for the year 1950-1961.
We hope your reviewing board will look favorably. on this application.

If the grant can be activated as of June l, 1950, we shall be asle to order certain itcns of equipment and thus decrease the delay which may result in changing our laborotories. I shall begin work in New Jersey as of July 1, 1950. If you or the officers of the re B a have any questions, I shall be glad to appear before your group to explain or justify any of the budgetary itens or cxpand on the details of the proposed research. A

We are proceeding with the tcsting of the-canpounds which has submitted.

Yours sincerely,

Carl C. Pfeiffer,/ M.D.

EMORY UNIVERSITY ATLANTA 22, GEORGIA

47-37

DIVISION OF BASIC HEALTH SCIENCES

March 28, 1950

OFFICE OF THE DIRECTOR

CCP:CW

[PAGE 70]
A B

ADear r

Attached you will find a copy of our budget report prepared on November 18, 1959 with encumbrances projected for the grant until June 1, 1950. From the report you will note that that the grant fron theB is being spent according to schedule and will be used up as of June 1, 1960.

Payments are conplete as of the present date, but a quarterly payment will be due Emory University on December-1,-1959.

Enclosed you will find uscead report for the first six months. Our report of drug testing at the Atlanta Penitentiary will be sent to you early in December.

Yours sincerely,

De Sskilfn Carl C.Prf.D.

CCP:CW

DIVISION OF BASIC HEALTH SCIENCES

November 20, 1959

OFFICE OF THE DIRECTOR

EMORY UNIVERSITY EMORY UNIVERSITY, GEORGIA

C

47-38

[PAGE 71]
AS OF: November 18, 1959

47-38

[PAGE 72]
Gentlenen:

We enclose the originel and one copy of our report of receipts and-expenditures in connection with the Erant to Fmory University, under the direction of Dr. Carl C. Pfeiffer for the period June 1, 1958 through 1ay 31, 1959.

Kindly\_inforn us if this report is not satisfactory.

Very truly yours,

1 1.ev
Ralpb C: Davis
/Chief Accountent M
RCD:dp
Encls:
ce: .Dr. C. C. Pfeiffer

C

EMORY UNIVERSITY FMORY UNIVERSITY. GEORGIA

47-39

October 5, 1959

[PAGE 73]
47-39

B

Departoeat of Poaracology

Dr. Carl C. Pfeiffer, Director

Sutiary of Receipts and Fxpenditures for the period June 1, 1958 throush May 31, 1959

Balance on hand 5-31-58
Received from-Geschickter Fund 1958-59

Direct Expénditures: t Expénditures:

\$ 24,880.12
Personnel 7,200.00
Fellowships 2:078.00
Huran. Subjects 707.01
Travel 9,703.39
Equipnent 2,318.30
Expendable Supplies Total Direct.Expenditures 46.886.82 4,578.18
Conjtribution to Indirect Cost Total Expenditures Overdraft es of 5-31-59 (To be absorbed by Rory University)

\$ 51,465.00 (\$ 1,106.02) Overüraft

\* See etteched schedules

APPROVED:

E-DAY UNIVFRSITY

Dr. Carl C. Ffeiffér, M. D. Project Director

\$ 2,156.98
48,202.00
50,358.98

Ce

De 15019

FMORY UNIVERSITY

SsS/Chezicel Divisten

I have cind pni ccd tho soattol exptnaitu:cs.

A

[PAGE 74]
Department of Fharuacology

Dr. Carl C. Ffeiffer, Director

Haran S.bjects

I havo ean:d cnl apr-e- the sutslttod ezpenditu-cs.

A ef

TSS/Chezlcal Division

Date: 15 Dcerinhnr 1959

47-39

[PAGE 75]
Datei 15 Decehv 1959

A ccmss

[PAGE 76]
Derartuent of Phanracology Dr, Carl C. Pfciffer, Director

EQUIPIENT

1 haveznisubsitted cxpenciiurcs.

A saon C:f

TES/Che=ical Division

tster 15 Deenhn 1959

[PAGE 77]
Continued to page 2

A Date: 159 1on

ENDRY UNTVERSITY

47-39

[PAGE 78]
Devertment of Pharracolosy Dr. Carl.C. Pfeiffer, Director

Pater 15 Dvcelur 1959

O

O

FIORY UNIVERSITY

B47-39

[3S/Ctc=ical Division

[PAGE 79]
47-40

RECEIPT-

Receipt is hereby acknowledged of the following two checks!

Official Check No. G35572, dated 3 September 1959, drawn on , in the amount of \$48, 378.00, payable to the

Caabier'a Check No, UT 5486, dated 3 September 1959, drawn on in the amount of \$1, 935.12, payable to the

Date:

108pr89

[PAGE 80]
24 August 1959

MEMORANDUM FORT CHIEF, FINANCE DIVISION

VIA :TSS/BudgerOlfleer

SUBJECT MKULTRA. Subproject 47, Iovolce f10 A1lotmeat 9-2502-75-902

1. Involce fl0 coverlog the above subprojoct le attached. Pavoeat sbould be made as followä:

Casbier's chcck In the amount of \$t8,378.00, drawa E 00140

Cashier's checkin the amount of \$1,935.12, drawa E

Each check should be made payablo to thee

2. Please forward tho check to Cblef, ISS/Chemlcal Divisloa through TSs/Büdget Cllicer by 4 September 1959.

3. Thle Isa flnal lavolce. Howevor, alnce it Is anticipated that additlonal funds will be obllgated for thls projoct, the flles: - shoold not be closed,

Attachmeot: Involco & Certifcatlons

Distrlbutlon: Orlg & 2 - Addresice

1-TSS/FASB 2-TSS/CD

TSS/CD/A

SECRET

C SEORET

[PAGE 81]
INVOICE

For Sorvice

\$50,313.12

CERTIFICATIONS

(1) It is hereby certifled that thls is Iavoice fl0 applylog to Subproject 47 of MKULTRA, that perfofmance is satlafactory, that services are being accomplished in accordance with mutual agreementa, that a detailed agenda of the paymento and recelpta ls on file In TSS/CD,.that this bill lo just and correct and that payment thereof had not yet been made.

Chief, TSS/Chemical-Division

Date:.

(2) It In hereby certifled that tbls invoice applles to Subproject No. 47 of MKULTRA which was duly approved, and tbat the project Is belog carrled out in accordaoce with the memorandum of 13 April 1953 from the DCi to tho DD/A, and the extenaion pf thlo authority In aubeequent memoraoda.

SECRET

Rescarch Director

[PAGE 85]
D

SECRET

No.2614

Cost Account0525-1009- 1402

Object Class.

b

SECRH

[PAGE 86]
SECRET

Cost Account.9. 2503.75.902

Object Class.

47-44

[PAGE 87]
MEMORANDUM FORI COMPTROLLER

ATTENTION

1 Finance Divislon

SUBJECT

: MKUl,TRA, SubproJect 47, Additlonal Authorltatlon No. 7

Under tha authority granted la the memorandum dated

13 April 1953 from the DCI to tho DD/A, and the extensloo of thls

authorlty la subiequeot memoranda, Subproject 47 bas beea

approved and \$S0, 313.12 of the over-all MKULTRA proJect funde

bap beea obligated to cover the subproject expensee. Thle

obllgatlon of funds ebould be charged to Allotment 9-2502-75-902.

A Chief TSS/Chemicat Divlaton

APPROYED FOR OBLIGATION OF FUNDS

Rciearch Director

CIRTIFY THAT FUNDS ARE AVAILABLE 1.95
ORIGATION ALCIRCE Ne. 2736
CHANG 10 . Y-2501.75 yal AUTHORIZCNG OFFICER

Dato: 3 0 JUR 1959

DIstrlbutlonl Crig k 2 - Addrctsee 1/TSS/OC -TSS/FASB 2-TSS/CD

C

47-47

25 Juao 1959

SEGRET

[PAGE 90]
MEMORANDUM FOR: THE RECORD

SUBJECT

: MKULTRA, Subproject 47

1. The purpose of this subproject is to provide fuads for the contiouation of the programn being carried out at Emory University under Carl C. Pfeiffer, M. D. The scope of this work basically covers the development and testing of new chemical compounds which are hallucinogenic or otberwisc affect the central nervous system of humjans. Certain phases of other problems, of interest to TSS/CD will be investigated.

2. The nature of the investigatione to be carried out under the direction of Dr. Pfeiffer encompasses the synthesis, pharrnacology and pertinent biochemistry of potential hallucinogenic.chernical com pounds. Testing and evaluation will be conducted io normal human voluntcers.

3. The funds for this project will be transferred using the B ro ao a cut-out.

4. The cost of this program for a Feriod of one year beginning

1 June 1959 will not exceed \$4,378.00. To this sur rnuat be added

Dovasraded χo: CG by 01y 01/ 147475 catp: juré 197p E2 JUPDET0L BY 187478

DRAFT/RK 25 June 1959

47-50

Doreces to:/CUFDEA ty aqtherity ft:f 187475 datcł June 1977 -E2-11D5CL B187475

[PAGE 91]
\$1, 935.12 representing a 4% service charge to the B inaking the total amount \$50, 313.12. Cbarges should be made against Allotment 9-2502-75-902.

B 5. has requested Emory University to submit to théin a summary accounting on an annual basis of all monies received from the . Also, it bas been requested that any uccxpended funds be returned as soon as possible upon the close of the grant year.

6. The requiremnent for a six months! informal accounting on the part of the principal investigator is waived.

7. Title to any perinanent equipment purcbased by funds granted the University shall be retained by the University in lieu of bigh overhead rates.

8. In connection with travel under this project, it is agreed that the Agency will accept the travel-documeptation and accounting which conform with the practiccs of the University.-

9. It is agreed that technical reports reflecting the progresa of the research program shall be subiitted at mutually acceptable intervale.

47-50

FIBENTIAL by epfcrity of 37475 cat Juno 197 7 E2 1C

Dor-aepa to: CEDIA by eut59:1ty of: y87475 date: ane 1977 E2 1NDET: CL EY187475

[PAGE 92]
DocrAced to:EFDTAL by auhorityof/187475 cato Jono 977 E2 1UPDET: CL BY187475

47-50

10. Dr. Pfeiffer has signed the Memorandum of Agree-

ment and holds a TOP.SECRET Agency Security Approval.

APPROVED FOR OBLIGATION OF FUNDS:

Date: 6|29159.

Attachrnent: Budget

Distribution; Original only

Rnred to: ty cuthority of: 1874/5 - ¿ate: (June 19/7 -E21NPET: EL BC37475

[PAGE 93]
the r B

PROJECr A.' The synthesis and drug enzywology of possible ballucinogenic chenicals

PRoJECT B. The Testing in normal human volunteers and the pharmacology of-experimental hallucinogens. Carl C. Pfeiffer, Ph.D.M.D., Principle Investigator

Total of both projects - \$48,378.00

WARNING NOTICE SENSITIVÉ INTELLIGENCE SOURCES ANO METHIODS INVOLVED

[PAGE 94]
WARNING NOTICE SENSITIVE/INT/LLIGENCE SOURCES ANO METNOZS INVOLPED

[PAGE 96]
CERTIFICATIONS

i (1) It is hereby ¿ertiried that this is Invoice f9 applying to Subproject 47 of MUlTR, that perforuence 1s eatiefactory, that services are teing accooplished in accordance vith rutual agreepents, that a detailed agenda of the myuents end reccipts 1s on file in Tss/cd, that this bill is just aod correct and that rayrent thereof hes Dot yet been mde.

Chief, TSS/Cheatcal Divisioa

Dater

(2) It is hercby certified that thla invoice spplies to Subproject Ño. 47 of KuLtsA Whtch was duly approved,-andl thet the project ie teing carried cut In ecconiance vith \_the \_perorandua of.13 April l953 fros the IcI to tho Do/A, and tho extenoicn or this euthority in subsequent penoranda.

A

29

Research Director

ST

47-51

For Services

INVOICE

\$33,420.06.

B

[PAGE 98]
Czart

Dera-teent of Fharmecolosy

Dr. Carl C. Preiffer, Director

Sucéry of Receipts and Expenditures for the periot Jno 1. 1958 thoush thy 31, 1952

Balance oa bond 5-31-58 B Foveivel fra  195-59

Direct Eqenditureat

Pereonsel \$24,880.12
Felloaships 7,200.00
Htan Sblects :2,078.00
Travel 701.02 9,703.39
Exdable Sipplies 2,318.30 Total Direct Eocdiituces 46,66.82
Constributioa to Iniircct Cost 4,518.18 Total Expcadttures Ovendrart. as of 5-31-59 (To be ebsorbed by rrciy Uaivereity)

See attechei scholules

AVTROYEDI

disd .Bpite Dr. Carl C, Pfeiifer/ M. D. Project Director

\$51,165.00 (↓1,105.02) Overdraft

I have exazined and arp:ovcd the sub=itted expenditurco.

\$2,156.98
18,202.00
50,350.98

EORY UIVERSITY

rss.Chectcs) Cixislen

47-53

A

[PAGE 99]
RIORY UNIVERSITY

Grant

Departrent of Fharnecology

Dr. Carl C. Freifrer, Director

Acount Fosition

Total Percoanel 24,860.12

I have exanined and approved the subsitted expenditurcs.

TSS/Checical Divis:on

47-53

Date: 5. Mereni 1757

[PAGE 100]
I bave cxezined and epprovod tbc sutzltted expenditurcs.

CSS/Cheztcal Divialon

Dates 5 Nevl 1751

[PAGE 101]
I haze akaninod and approved the sutaittet expendituree. n

47-53

Detor Nrnemn > 1

SSS,Chezital it'sioa

[PAGE 102]
EMORY UNIVERSITY

Contimed. o mge 2

[PAGE 103]
I have exanin cnd cprrovd the subaltted expenditu:.

al Dvsion

Dator 5twii 1959

ENOBY UIVERSITY

47-53

[PAGE 107]
2oxaC9as04 :CCF00AL by euf or1yy pr: 187475 cate 1 Jane 1977 52  CV 7478

\- MEMORANDUM FOR: TRE RECORD SUBJECT : MÈLTRA, SubproJect 47

1. The purpose of this subproject 1s to provide funds for the continvation of the progran being carried out at Emory University under.Dr.-Carl C. Pfeiffer. The scope of this work is outlined in-the attached proposal subaitted\_to Drs. Pfeiffer and-and basically covers the development eoi testing of new bellucinogenic-conpounds as well as certain phases of other problems of interest to TSS/cD.

2. It should be noted that es in past -years, a consider
able portion of the total cost of the indicated progren will be
borne by agencies other than TSS/CD. These inclüde the U.S. Publie B
Health Service, Eoory Univereity, p and others.

3. The funds. for this project will te transferred using 1 the oh, as cutout in the ususl manoer.

4. The cost of this program for a period of one year, beg1nning 1 June 1958 vi11 not exceed \$h8,202.00, tō which must be B added the four percent (L%) fee to the , making the total amount \$50,130.08. Charges should be made egainst Allotcent B-2502-10-001.

B 2

Downerzded:CONFIDENTIAL by a2/ho21y/ of: 37475 catof Jund1077 E2 1P2ETCLBY 187475

47-56

DRAFT 19 June 1958

[PAGE 108]
CL BY 1b7575 súbmft'to thea a sumaary accounting on an annual basis of all monies received froe the Fund. Also, it has been requcsted that any unexpended funds be returned as soon as possible.upon the close of the grant year.

6. The requirement for a six months' informal accounting

on the part of the principal investigetor is vaived.

7. Title lo any permenent cquipoent purchased by funds granted the University shall be retained by the Uaiversity in lieu of higher overheai rates.

8. In coninection vith travel under this project, it is agreed that the Agency vill accept the travel ocumentation and accounting vhich confora with the practices of the University.

9. It is agreed that technical reports reflecting the progress of the research progras shall-be sutmitted at wutually acceptable

intervals.

10. Dr. Preiffer has signed the Menorandum of.Agreement

end holãs a TOP SECRET Agency Security Approval.

47-56

TSS/Chemical Division

Distributlon: Original only

APPROVEDFOR OBLICATTONOFFUNDS:

Domcrees to: COEUY ty a2t9.1ty 0f: 1547 éate: Jfae 1977 12 113 21: C 8Y 167475

[PAGE 109]
1. Continued testing program in animals and man of the potential hallucinatory chemirsror which become available fron C cals which have been synthesized by a comerciallaboratories..now has 30 chemicals awaiting testing in man. C :atr mndifies the LSD-25 model psychosis

2. 2-dimethylaminoethanol in preliminary trials moolries us L in that the onset of symptoms is delayed but in the individual subjects the visual frequent. A double blind test of rigid design will be hallucinations are more set up to quantify this effect. set u u 1 ronde will be deter-

3. The possible occurrence of 2-diwethylominoethanol in natural foods will be determined by steam distillation and paper chronatography. minea dy sleom -artsin tts

4. Tests will be made on ćarnitine and its tertiary amine derivative to ascertain its possible role as a neurohumor in-the central nervous systen. posstuic. hvtansively

5. The D and L forns of lactylcholine have been synthesized and will be extensively tested in animals to asccrtain the possible similarity to acetylcholine. Other natural occurring alpha hydroxy acids will bc esterified to choline to determine their potency.

6. Continued testirig in man and animals of those compounds which may. be subnitted B bythe bytnevne= -.:d.ra activity

7. Determination of the effect of candidate hallucinogens on d-aninoxidase activity

PROPOSED RESEARCH FOR 1958-59

47-54

WARNING NOTICE SENSITIVE INTELL/GENCE SOURCES AND NETHODS INVOLVED

[PAGE 110]
PROPOSED BUDGET 1958-1959

Director, Carl C. Pfeiffer (partstime) \$3,000. Asst.Prof.i 5(ful) 8,000 2 Physicians (Follows) Atlanta Penitentiary 3,000 3,000

10% UNIVERSITY OVERHEAD

SQURCLS ANDKETHOOS INVOLVED

\$29,720.

47\~56

Department of Pharmacology Car] C. Pfeiffer, Ph.O., M.D.

TOTAL PROPOSED BUOGET

\$14,100 \$43,620 4,382 \$48,202

[PAGE 111]
90. 9677 8-5sc2-1-01

[PAGE 112]
KHORANDUM PORI COPTROLLER

ATTENTIOA Firance Divioica 2

T

QAJXT

1M, Btproject 47, Adtical Autborisstico ro, 6

Voder the authority eiénted in the sosorpnhua dated

13 Apr1l 1953, froa the DCI to tha Do/A end the extensio

of this authority in subsoçuent neornda, Sutprojeet 7

vas peviously approved, Uoder the saso cuthority en ci-

dittocal sus of \$50,130.03 tas been euthorized to cover the

eubprojoct's expentes (theredy tringing to a total of 50,130.08

furds obligated during 1r s0) to to chereod to Allotoont

8-2502-10-001.

A Chief TSS/Cheaical Divlston

AFPROVED FOR OBLIGATICI O PUIEST

Reccarch Diroctor

-41958
ICETT TATFS AE AVARASLE 278
1102501001

Lator

Metributicat Crig & 2 - Aidrcesoe

1- TSS/∞

ví- 133/FASB

1 - TS/SKB

2 - T2S/CD

47-58

19 Jume 1958

[PAGE 113]
7

EMORY UNIVERSITY

B macolo

Departrent of Flharmacology ant

Dr. Carl C. Preiffer, Director

Sunary of Receipte cod Expenditures ror the Period June 1, 1957 through Nay 31, 1958

B Received fromw

\$489,421.00

Total Direct Expenditures Contritution to Indirect Cost

442,058.20
4,205.82

Total Expenditures Total xcu

46,264.02
\$2,156.98

Unexpended Balance as of 5=31-58

\* See attached Schcdules.

EMORY UNIVERSITI

Approvedt

Carl C. Ffeiffer, M. D. Project Dixector

Fugh B. Hlllisrd, C. P. A. Chier-Accountant

9759

[PAGE 114]
Departrent of Pharmacology

Dr. Cerl C. Preiffer, Director

Total Personnel

FELJONSHIPS

Total Fellovships

EMORY UNIVERSITY

47-.59

[PAGE 115]
meaCrant

Dr. Carl C. Pfeiffer, Director.

Date Individual Destination Ck.NO. Ampunt

6/28-30/57 Dr. Carl C=PreirferCh1cago.38761\$ 71.26

8/23-30/57 Dr, Carl C. Pfeiffer e 41237 110.96

C8/23-25/57SJ-8-14784.37

9/3-7/57 Dr. Cerl C. FreifrerWashington,D.C.b1844245.61

9/3-10/57418834.60

12/5-6/57 Dr. Carl C. PreifferWeshingtoa,D.C. 46370 103.10

1/24-21/58 Dr. Car1 C. Pfeiffer . Kev York City & Middletoo, Conn; hg471 183.70

4/11-18/58 Dr.Car1 C. Pfeiffer Chicago and Philadelphía 54262271.85

Total Travel \$1,135.45

47-59

EMORY UNIVKRSITY

[PAGE 116]
EUTINRNT

[PAGE 117]
B

Departrent of Fhairacology Dr. Carl-C-Pfeiffer, Director

EXPZODABLS SUPPIJES

47-59

EHORY UNIVZRSITY

[PAGE 118]
AMOUINT ITEN

47-59

EXPENDABLE SUPPIISS

[PAGE 119]
I hereby acknowledge receipt of the following two checks:

Cashier's Check No, ,dated April 30, 1958, drawn on o., in the amount
The
of \$32, 280.67, payable to the

drawn on Registered Check No. amount of \$1, 291, 23, pay able to the

3V.+80.67 129123
2357190

RECEIPT

47-40

[PAGE 120]
VEORANDUH POR CHIEP, FIRANCE DIVISION 1Tss/Bdget Ofricer
VIA 1LA, Subproject 47, Iavoice No. 7,
SUEJAT BUWW Al10t0nt 7-2502-10-001 Alou

1. Invoice No. 7 covering the ctove subproject is attacted. It is requested that payocat bo made as follovsi in the ext or \$32,280.67, drava

Zach chock should te rrus 2. Tho checks ahould to forvarded to Chier,i Ts/cheoical mtaton. through sss/Dudget officer, no later then liednesday, Division, tnruue nntlv

7 ky 1953, 3. This invoico represents the-total eoaunt currently
euthorized under Butproject h7. Fovever, sinco It is antici
pated that eaditbnsl fuis vill be obllgated for this project,
the files should not be closed. A

Attectpentsi Involce & Certificaticos

I CERTFY THAT TUNDS ARE AVARLABLE AURIKP2

47-41

22 Apr11 1958

[PAGE 121]
CERTIFICATIORS

(1) It 1s hereby ccrtiried that this 1s Invoice No. 7. epplying to Subproject 47 of MULTrA, that rerforonnce 1s satisfectory, that services ero being eccoplished in accortence vith mitual eereenents, that a deteiled egenda of tho paypents end réccipts is co file in Tss/co, that this bill-is just and corroct and that peypeat thereot bas not yet beon nede.

Chief, TSS/Chenical Division

Dater
(2) It is hereby certiried that this invoico epplies to Subproject 47 of HulirA vhich vas duly approvei, and that' the project is being carried cut 1n accoriance vith the meporaniun dated 13 April 1953 fros the ICI to the Do/A, end the extensica of this authority in sube sequent penorenda.

INYQICE

\$33,571.90

47-41

For services

[PAGE 123]
(2) It Is berey cortified that thia involce applics to Subproject f47 of MKULTRA wblch waa duly approved, and that the profect is being carried outin accordance with ths memorandui dated 13 April 1953 from the DCi o tho DD/A, and tho exteasion of thls authority in sub. equent meporanda.

[PAGE 124]
RECEIPT.
I bereby acknowledge receipt of the following two checks:
Cashler's Check No, a3 dated August 23, 1957, drawn on Pin the amount The B
of \$16, 140.33, payable to thew
Cashier's Check Check No. dravn on tbe in the amgunt ot \$645. 61, payate B
to the Date: S1 hugS7

[PAGE 125]
C

EMORY UNIVERSITY

el Grant

Deputrent of.Phartacology Dr. Carl C. Pfeiffer, Dircctor

Srzary of Receipts and Expenditures for the Period Jane 1, 1956 through May 31, 1927

Unexpenled bslence May 31, 1956 B Receivet fro  this leriod Total Furds avallable this period

\$371.38
47,403.00
\$47,780.38

Direet Expenditures:\*

Contribution to Indirect Ccst.

Total Expenditures

\$16,310.96 expenditures. I have ezamined and an viteres.

Credit Falence a0 of May 31, 1957 (Emory Vaiver6ity will-abcorb thie oveidraft)

#Sce attached schcdulcs

Approvedı

Carl C. Pfeiffer, M. D./ Project Director

Evell Z. Bessent, C. P. A. Coutroller

C47-64

[PAGE 126]
expenditures. I have exazined and tpzroved the sutsitted

cnief Dates TSS/Checical Division BUL 2 3 1957

47-64

[PAGE 127]
47-64

[PAGE 128]
Departuent of Pranacoloey Dr. Carl C. Pfeiffer, Dircctor

EQUIINGNT

Total Equipvoent

I have exazined and
expoaditures. Eprored the subzitted

EIORY UNIVERSITY

47-64

[PAGE 129]
Departrent of Phanscology Dr. Carl C. Pfeiffer, Director

Grant.

47-64

FXPANDABLE SUPPLIKS

Ausount Iten

Arount

MORY UNIVERSITY

[PAGE 130]
EXPENDARLE SUPPLIES

Ite

Continued froa Fage 1

Total Expendable Supplies=\$4237.2

Pege 2

EMDRY UNIVERSITY

47-64

[PAGE 132]
MEMORANDUM FORI COMPTROLLER

ATTENTIONI Flnance Diyislon

SUBJECT

MKULTRA, Subproject 47,Addullogal Authorlzatlon No. \$

Under the authorlty granted In the merorandum dated 19 April l953, from the DCi to the DO/A and the extension ol thls authorlty in subsequent memoranda, Subprolect 47 was. prevlously approved. Under the same authority an additlonal sum of \$50, 357.84 bas been authorized to cover the subprolect's expenses (thereby bringing to a total of \$50, 357.84 funds obllgated during FY 57). to be charged to Allotment 7-2502-10-001.

SIDNEY GOTTLIEB Chtef TSS/Chemtcal Divislon

APPROVED FOROBLIGATION OF FUNDSI

A Jricizal Signed by

Research Director

2e

Datel1AY 29 1957

Distrlbutlont

-Orig& 2- Addressto

1 TSS/CD: (24 May 57) A

H/C SPO 1045

47-16

24 May 1957

[PAGE 133]
1. The purpose of this subproject is to provide funds for the continuation of the program being carried out at Emory University under Dr. Carl C. Pfeiffer. The scope of this work is outlined in tho attached proposal submitted by Drs. Preifferand ww and basically covers the development and testing of new hallucinogenic compounds as well as certain phases of other problerns of interest to TSS/CD.

2. It should be noted that as in past years, a considerable
portion of the total cost of the indicated progçam will be borne by
agencles other than TSS/CD. These Include the U.S. Publie Health
Service, Emory University, the Rrcx and others. 2 D

3. The funds for this project will be transferred using the ,as cutout in the usual manner;

4.  The cost of this program for a period of one year, beginning 1 June 195] will not exceed \$48, 421. 00 to which must be added gart making the total the four percent (4%) fee to th amnount\$50,357.8450,130.08 3

5. The has requested Emory Unlversity 15 to submit to them a summary accounfing on an annual basis of all monies reccived froin the Fund, Also, it has been requested that any unexpended funds be returned as soon as possible upon the close of the grant year.

6. The requirement for a six roonths informal accountíng on the part of the principal investigator is walved.

7. Title to any perinanent equipment purchased by funds granted the University shall be retained by the University in lleu of higher overhead rates.

8. In connection with travel under this project, it is agreed

Douneyeéed to: CONDETIAL ty cfhorityot: 137475 catef Jne1977 E2 :CL BY/187475

bev reed tu 1674 5 ty caforit éate Jung 1577

E2 IPDET; CL BY 187475

DRÀT 24 May 1957

47-6

MEMORANDUM FOR: THE RECORD

SUBJECT:

45,202.00

MKULTRA, Subproject 47

[PAGE 134]
by sut7rity 18775 caté: fane yor

47-67

187475 that the Agency will accept the travel documentatlon and accounting which conform with the practices of the University,

9. It is agreed that technical reports reflecting the progress of the research program shall be submilled at mutually acceptable intervals.

io. Dr. Pfeiffer has signed the Memorandum-of Agreement and holds a-Top Secret Agency Security Approval,

Chtef, -Rranch-1 TSS/Chemical-Division

APPROVED FOR OBLIGATIONAPPrOVed: FOR OBLIGATION OF\_EUNDS:

Date:57

A Chtef, TSS/Chemical Division

Attached: Proposal

Distribution: Original only

Dovccrepa to: COIOLHTIAL ty outhprity 9f: γ87475 cate:  1977 12 12 CL EY 157475

7-n n…

[PAGE 135]
Human volunteers - Atlanta Federal Penitentiary

1.potentiation of LSD-25 psychosis with cortisone

2. Trials of ncw hallucinogcnic agents

3.Dibenamine and Dibenzyline as antagonists to LS0-25

.4. Search for new antagonists to LSD-25 .4. Search tor new dntayisls  L

S. Trials of the so-called inactive isoner 1-LSD-25 as a hallucinogen

6. Trials of other CNS active drugs

8.Pharnacological and biochrmical studies

'1. In vitro.studies of candidate.hallucinogens on\_enzyme systems a. Cholinesterases, b. Mono- and diamine oxidases, c. Glucose metabolism of S. cerevisiae, d. d-amino acid oxidase

2. Effect of candidate compounds on rabbit body tanperature

3. Effcct on activity of mice

Gaddun rat uterus-inhibition of 5-HT

5. Pharmacooynamic stoues  c
6. Chronic toxicity and safety studies on promising compounds before trial in man

7. Pharmacodynamic studies on optically active esters of choline.

c. Chemical synthetic program

1. Synthesis of substituted piperidine carboxamides

2. Synthesis of aryl alkyl amine derivatives

3. Synthesis of indolyl alkyl amine

4. Synthesis of optically active esters of choline

5. Synthesis of a few additional salts of 2-dimethylaminocthanol

D. clinical studies in schizophrenia.

1. Continued trials of 2-dimethylaminoethanol in patients

2. Trial of naturally occurring sulph hydryl compounds in schizophrenia

47-67

WARNING NOTIDE SENSITIVE INTEICIGENCE SOURCES AÑO METHODS INVOLVED

PROPOSED RESEARCH PROJECTS FOR 1957-58

[PAGE 136]
1 The experimental subjects are a group of sixteen volunteers, inmates of the U.S. Federal Penitentiary at Atlanta, Georgia. Healthy and emotionally stable (as determined by psychomctric tests) individuals are chosen. Their mean age at present is 34 years, their mean weight is 160 pounds. Their 1.Qs. range from 90 to 123. The doses of drugs are administered at-randon at weekly intervals. Al) subjects have experienced the effects of-central nervous system stimulants and depressants. They are able to idcntify and to comunicate the subjective responses to these drugs and have proven that their responses are soncwhat reproducible.

Tests are carried out iq'a hospital roon. The subjects are encouraged to stay in bed during the trials. Drugs are administered orally, two hours after a light morning breakfast. Testing is usually done single or double blind.The drugs are handcd to each subject in a small labeled bottle. The label bears only the name of the subject. The subjects place the tablets-or-capsules-in their mouth under supervision of the physician and wash them down with a cup of quinine flavored water. The evaluation of 'the drug effects is bascd on thrce types of responses.

A. Observations are made by the-attending doctor during a thrce-hour test period following administration of the drug. These include measurements of blood pressure, pulse rate, body temperature and hand steadiness at 60 or 90 minutes intervals. It also includes observations on the neurological and mental status of the subjects, such as alertness, sleep and arousal fron slccp.

B. A personal interview is made at the cnd of the three-hour period. In this interview the subjcct is encouraged to\_tell his feelings under the influence of the drug and coopares\_them\_with similar or dissimilar cffects which he may have cxperienced with the other drugs on previous trials.

C. Twenty-four hour statement. The subjects prepare a written statoment of the effects experienced in the twenty-four hour period after the administration of the drug. The criteria for the cffects were established by the subjects themselves. Subjects were told either after the interview or after they had prepared their written statenent which drug and dose had becn administered.. This incrcases their degrce of drug sophistication and allows them to evaluate new drug effects.

47-47

WARNINGNQTICE SENSITIVE IVTELLIVENCE SOURCES AND RETHOOSVIVOLVED

[PAGE 137]
A careful study of SAR of acetylcholine Ach and atropine-like compounds indicates that the naturally occurring Ach-like conpound should have an asyametric carbon aton in the acid moiety. The evidence for the existence of Ach in body fluids is tenuous since identification has bccn made only by Rcineche precipitation which method only tests for quaternary nitrogen containing compounds. A few of the optically active acids which might be esterified with choline are lactic, pantothenic and ascorbic acids. These analogues of Ach are therefore in proçess of being synthesized to determine their pharmacodynamic effect.

C 47-67

WARNING NOTCESENSITIVE INSELLIGERCESOURCES AND DETHODS JINVOLVEO

[PAGE 138]
COXFOUITS HAVING A POTENITIAL EFFECT UPON THE CENTRAL NERVOUS SYSTEM

WITH EAFHASIS UPON MOIETIES ORIGTIATING FALLUCINATORY EFFECTS

I. The vork was continued in accordence with-the outline of the Third Report, subsitted in Déccaber 1956.

A. Substituted Piperidinecarboxanidest

(1) coapounds synthesized end postulated structure confircd:

e. 1-methyl-3-(N-methylcerboxecido)-1,2,5,6-tctrahydropyridine hydrochloride (C-36)

b. 1-methyl-3-(-cthylcarboxerido )-1,2,5,6-tetrahydropyridine hydrochloride (G-37) nyarocmoriue

c. 1,1-bis/3-(N,l-diethylcerboxanido)piperidino/methene (G-109)

(2) work in progresst work in progresst

a. synthesis of 1-scthyl--phenyl4-(,N-diethylcerboxeuido)piperidine hycrochloride (C-38)

B. Arylalkylasinc Derivatives:

(1) co:pounds synthesized and postulated structure confiraed: a. li,l-diethyl--bronopropionaside (GI-103, X), intermediete b. l-phenethyl--acthyl--alanine diethylaide hydrochloride (G1-10ł, XI)

C. Indolylalkylanine Derivetives:

(1) cozpounds synthosized end postuleted"stiucture confiraed: (1) cospounds synthesized end postuletea structure conilinaçu.

a. 4-(,-dicihylamino)buty1 3,4,5-trisethozybenzoate (GI-503,XXIX), eliphatic analogue of rescrpine

b. 4-(,-dichylazino)butyronitrile (G1-551, X111), intenediete

e. 4-(1.-dicthylenino)butylezine (GI-552, XIV), interzediate

(2) work in prögress:

e. synthesis of 1-/4-(H,l-diethylaaino)butyl/-3,4,5-tri:ethoxybereezide (GI-53, XxX), eliphatic enalogue of rescrpine

b. synthesis of l-foryltryptenine (CI-201, XIv), interediate

I1.In edcition to the vork eircedy in progress, new projects heve been undertaken.

A. Utilizing the products of our syrthetic progres, we are planning to study the effect of gradusl chenges in poleculer constitution upon encyes es-

SOURCES AND METHIODS INVOLVED

47 -48

[PAGE 139]
sociated with brein metabolisu and, possibly, upon other pertinent biochesicel systczs,in vitro. Based on the information aveileble at the prescnt tine, the systens listed below ere being considercd for tho first seriesof evaluative experinents. While we reslize that their causel cornection wiih helucinatory disturbances hes not been conclusively esteblished, we fcei that they constitute a suiteble starting point, In each instance, known psychotocinetic asents will be\_evalusted elong with our conpounds. (1)/cholinesterases:

e. acetvlcholinesterase (substrete: ecetyl-:-sethylcholine; compounds studied: pyridinc- and piveridinecarboxylic acid, erylelkvlenine and indolylalkylenine derivatives;effects studied: inhibition and/or potentietion; nethod: Warburg manonetric technique)

b. pseudocholincsterese (substrate: butyrylcholine and/or benzoylchc line; cospounds studicd: pyridinc- end piperidinecsrboxylic acid, erylalkylemine and indolylalkylesine dcrivatives; effects studied: inhibition end/or potentietion; rethod; Warbure nanozetric technique) innibition end/or potentietion; rethod; Warburg nanozetric technique)

LsDwesfound to be a powerful inhibitor of pseudccholircsterase in huan iserur and brain. Pseudocrolinesterese ectivity of rat guinea-pig, rabbit, chicken and nonkey brain is much less sensitive to irhibition by LsD then is the corresponding enzyme in hucan brein. /Pseudocholinestorase was inhibitcd pore powerfully by LSD then by other ersot alleloids. (R. H. S. Thompson, A. Tickner-end-C. R. Webster, Brit, J. Pharscol., 10: 61, 1955.) ISD was found to inhibit (50s) pseudocholinesterese activity at a lxl0-0N. concentration and was found to eugrent (5o%) the ectivity ofthe enzyre et 6xloM.concentration.Siniler observations were reported for serotonin (5ydroxytryptanine). (e. H. Fried and W. Antopol, Fed.-Proe.,-16:-357,-1927. Meperidine (1-nethyl-h-phenyl-h-cerbcthoxypiperidine) end other iarcotic anelgesics capable of producing hallucinetions vere reported to potentiate (42-l39) the hydrolysis of bencoylcholine by piseudocholinesterase at concentrations ranging fron 10to 10-4  (s. G. Erdos énd S. P. Shanor, Fed. Proc., 16: 297, 1927.)Tryptanine'end beneylezine (phenylmetylazine) were found to activate (4z-9%) the hydrolytic action of pseudocholinesterase upon benzoylcholine. (E. G. Erdos, F. F. Foldes, N. Eaart end S. P. Shonor, Fed. Proc., 16:-294,-1957)-

(2) anine oxidasest

e, poncamino oxidasc end b. diarine oxidase (substrate: arylelkylanine and indolylalkylanine derivatives; coupounds studied: Iowm and potential inhibitors, our pytidinc- end piperidinecarboxylic ecid derivatives; effects studied: inhibition end/or potentiation, evaluntion of reletionships in the substrete affinities of the two enzyzes; iethod: Werburg menonetric technique)

Honoamine oxidese is considcred to be a njor cetelyst of serotonin uetabolisn in tissues. Iproniezid is-reported to inhibit monosuine oxidese in tho brain, but wable to penetrete to the site of monoerine oxidace in intect cella of other tissues. (H. Weissbach, D. P. Bogdanski, B. Redfield and S. Udenfriend, Fed. Proc.,16: 45, 1957.) Reletionships betveen ronoenine oxidese end dianine oxidase vere reported. There is indication that the affinities of the two enzyes ere overleping; however, soze of their charecteristies have been found to retein their specificities. Vesceline (3,4,5-trinethoxyphenethylasine) ard tyrazine were reported to be eeong the surstrates of dianine oxidase, while soze p-asinoothylinidasoles were found to be sub stretes for monoezine oxidase. (£. A. Zeller, J. Earsky, L. A, Plenksze, end J. C. Lazaras, Fed. Proc., 16: 276, 1957.)-

Seccherocyces cerevisiee:

S. cerevisiee (substrate: slucose; ccspounis studied: pyridine- and pipe-

C

C

Fage Two

SOURCES AND METH SENSIIE TETEADSHINVO WARNING NGTICE

47-46

[PAGE 140]
ridirccerboxylic acid, erylelkylemine end indolylalkylenine derivatives; effccts studied: inhibition end/or potentietion of carbohydrate metabolisa es detcnincd by renozetric estination of oxygen consuaption; uethod: tarburg menonetric technique; en exploratory study of the effect of our conpounds upon. the glycogen nctabolisa of S. cerivisiae is also conteapleted) conteaoleted) r renorted to inhi

LSD end mesceline (3;4,5-trinethoxyphenethylenine) were reported to inhibit respiretion qf S. cerevisiae (substrete: glucose) at 10-3 to 10-4 and l0-2H. concantrations, respectively. (H. P. Rieder, Confinia-leurologica, 14: 65, 194.)- Clinicel investigations suggested thet LSD induced hallucinations pay be due to interference with norael carbohyärate metabolisn. (V. Heyer-Gross, V. McAden end J. W. Balker, Nervenarzt, 23: 30, 1952.; ef. Neture, 168: 827, 1951 end-J.Menta1 Sci., 99: 804, 1953.)-

B. In connection with the-investigation designed to develop reans for en inproved supply of puscarinic egents-to-brein-tissue,-Dr. Ffeiffer sucsested the preparetion of the following conpounds:

(1) the dl, 1 end d isoners-of lactylcholine 1t1

(3) the choline cthers of  end l-ascoruuv avs the choline cthers of &and l-ascorbic acid

The dl-lactylcholine iodide has been Alrpaey prepered, the postuleted structure was confirned,-snd a synthetic-procedure was developed which may be. of value in industriel processing, should the compound or eny of its isoners posses chesotherapcutic potcntialities.

C. In connection with the-DoanerProject, vr. riellel suso (1) exploratory work to-detensine-whether 2-dinethyleninoethanol is precent in dctectable quentities in food wetériels, in dctectable qunntitles in vuu wav -h the folowin

(2) the preparation of salts of 2-dincthylezincethenol with the following ecids:

e. d-pantothenic acid

b. d-pentoic acid

c. p-ecetylaminobenzoic. acid

d. dl-mandelic ecid The d-pantothenic acid end ¿-pentoic ecid salts heve been prepered. Acditionel quentities of\_elready known salts have elso been prepered.

Eory University, Kay 17, 1957.

WARNING NOTICE SENSITIVE INTELLIGENCE SOURCES AND METHOOSINVOLVED

C

Pege Three

C

47-68

[PAGE 141]
A Grant to Department of Pharnacology, Eory Unlverslty CarI C. Pfeiffer, Ph.D., H.D., Principal Investigator

June 1, 1957 - May 31, 1958

WARAING NOTICE SENSÉTIVE INTECLIGENCE URCES ANO BZTHODS INVOLVED

PROPOSED BUDGET 1957-1958

47-69

[PAGE 142]
June 1, 1956 - ay 31, 1957

[PAGE 145]
CERTIFICATIONS

(1) It Is hereby certifled that this Is Involce No. 5 applylng lo Subproject 47 of MKULTRA, that performance is satisfactory, that the services are being accomplished in accordance with mutual agreements, that a detailed agenda of the payments and receipts is on file In TSS/CD, that this bill Is just and correct and that payment thereof has not yet been mnade.

Chief, TSS/Chemical DIvision

Date:

(2) It ts hereby certifled that this Invoice applles to Subproject 47 of MKULTRA which was duly approved, and (hat the project is belng carrled out In accordance wlth the memorandum dated 13 Aprll 1953 from the DCI to the DD/A, and the exteoston'of thls authorlty In subsequent memoranda.

Research Director

INVOICE

For services

[PAGE 148]
CERTIFICATIONS

(1) It Is herèby cerlifiēd that this is Involce No, 4 applying to Subproject 47 of MKULTRA, that performance Is satisfactory. that the services are being accomplished in accordance with mutual agreements, that a detalled agenda of the payroents and receipts Is on file In TSS/CD, that thts bill is just and correct and that payment thereof bas not yet been made.

Actiog Chief, TSS/Cheinical Dívision

Date:

(2) It Is hereby certifled thal thts Involce applies to Subproject 47 of MKULTRA which was duly approved, and that the project is belng carrled out In accordance with the mernorandum dated 13 April 1953 1rom the DCI to the DD/A, and the extenston of this authority In subsequent memoranda.

Research Director

INVOICE

47-74

For services

\$16,433,04

[PAGE 150]
MEMORANDUM FORL COMPTROLLER ATIENTIONFIaance Diviston

MKULTRA Subproject 47, SUBJECT Addlllonal Authorizatióa 14

1. Under the autbority granted ln the reemorandum dated 13 Aprll 1953 fror the DCI to the DD/A and tho extenslon of this authorlty In subscqucnt memoranda, Subfroject 47 was prevlously approved. Under the saroe authorlty an additloaal sum of \$49, 299.l2 bas been authorized to cover the subprojectis expenses (thereby brlnging the funds obltgated duriog FY S5To a tota1 01 38, 174.36).

2. Thls expendlture should be charged against Allot ment 6-2502-10-001.

1 CERTIFY THAT FUNDS ARE AYARARE 20,JUN CRUGATICN RTRNCEN52 (H210 10.6-3502.10-001

AUTHORLING OHFICER

SIONEY GOTTLIEB, CMel, TSS/Cherical Division

APPROYED FOR OBLIGATTON OF FUNDS:

pistributton: 771 Orlg & 2 - Addrcssce

Research Dlrector

LPI TSS/FASEE

1- TSS/SRB

47-74

7 June 1936

[PAGE 152]
-SUBJECT

: MKULTRA, Subproject 47

1.fThe purpose of this project is to provide funds to coatinne the research program.conducted by Dr. Carl Pfeiffer at En ory-University. rhis program is designed to exploit all the knowledge and facilities available to its director in providing answers to specific questions of direct interest to the Agency. In addition, those areas of basic knowledge required to provide these practical answers will be developed, It should be noted that although the attached proposal describes the facilities which will be used in the stuiy, the rogram itself was deliberatelydeseribed in géneral overt terms in order to comply with its unclassified statts.

2. In view of the above it\_is\_desirel to describe more specifically the various phases of the general progtam. here:

(a) A relatively small part ofthe program will be in the fundamental tield of the relationship of structure to activity. This basic study will be of an overt nature and will serve the purpose of maintaining cover for theA e support of the progran.

47-77

Dorncreped to ONFIOGTIAL by cuthority of 187475 date June 1977 E2 JPOET; C BY 187475

DRAFTAER

7 June 1936

MEMORANDUM FOR: THE RECORD

[PAGE 153]
A second phase will be represented by an extensive effort on behalf of Dr. Preiffer to find a solution to the requirempent for an anti-interrogation drug. This requirement was laid on TSS/Chemical Division by another Agency component,

(c) A third phase of the program will provide screening and evaluation of compounds subiitted by TSS/CD, including the phases involving tests \in human volunteers.

3. fhe funds for this project wilt be transferred using the eas cutout in the usual πanner. B

4. Costs for this program for a period of one year beginning l June 1956 are estimated to be \$47, 403.00, toB which must be added a four percent (4 %) fee to the , making the total amount \$49, 299.12.

University to submit to ihem a summary accounting on an annual basis of all monies received from the Fund. Also, it has been requested that any unexpended funds be returned as soon as possible upon the close of the grant year.

6. The requirement for a six months informal accounting on the part of the principal investigator is waived.

7. Title to any permanent equipment purchased by funds granted the University shall be retained by the University in lieu of higher overhead rates.

-2.

DoeAs-aded- to OORDENTIAL by outerityof: 187475 cato:June 1977 F2 IPD7T: CL BY 187475

47-77

[PAGE 154]
8. In connection with travel under this project, it is agreed that the Agency will accept the travel documnentation, and accounting which conform with the practices of the University.

9. It is agreed that technical reports.reflecting the progress of thè research program shall be submitted at mutually acceptable intervals.

APPROVED:

Sidney Goutljeo, Chief, TSS/Chemjcal Division

APPROVED FOR OBLIGATION OF FUNDS:

-Altachment: Proposal & Budget

Distribution: Criginal Only--TSS/CD (Date) mne 11 1456. A

Pmnceaand tot EylElL by autyority of:/187475 date:June 1977 E2 IFET; CL BY 187475

47-77

Doved to:ONFIDENTIAL ty cutfsrity fe 187475 cate:/Jno 1977 £2 1PDET CL EY137425

LL

[PAGE 155]
It is proposed to continue the work at Emory University which has been conducted during the last two years by Dr, Carl C. Pfeiffer under thenominal title,"The Pharmacological Screening and Evaluation of Chernical Compounds Having Central Nervous System Activities."

The program at Emory is necessarily divided into several

parts, some of which are supported by grants other than that of

the Ctecs ycwpbut which are operated as integral parts of

the program. Other agencies who contribute are Emory University

and the U: S. Public Héalth Service.

Facilities which contribute a major portion of their capacity toward the program are as follows:

1. ewevmmotraction Laboratories at Emnory University under the direction of C

-2. Neuropharmacology and Electrophysiology Laboratorics at Ernory University under the direction of

Darhsracet to: TUnpElnint 187475 by auyhority t: date June 2977 F2 LOD2T: CL BY 187975

47-77

PROPOSÀL

[PAGE 156]
to:CODENTIAL by ou159rity ef: y87475 cate: Jne.1977 E2 15PDEP; CL BY 182475

47\~77

3.. Gencral Animal Pharmacology Laboratories at Emory University under the direction of Professor, Carl C. Pleiffer.

1 4. Behavioral Psychology.Laboratories (Animal) under the direction of the Department of Psychology at Emory University with auxilliary animal testing laboratories under the direction of in the Department of Pharmacology.

. Fäcilities for preliminary human pharmacological testing alortdg

6. Facilities for testing in normal human volunteers at Atlanta Federal Penitentiary directed by Professor Pfeiffer.

The general program to be continued by these various facilities is the discovery and complete sereening and testing of a number of inaterials capable of producing alterations in the human central nervous systen, which are reflected as alterations

(2)

Dossfoacd to CNFIDEIAL ty auherity of: 187475 cate: E2.13: CL(BY 17475

[PAGE 157]
in human behavior.. Such fundamental research on mechanisms of action and structurc-activity relationships. as is necessary to the consistent production of such materials will be undertaken as required in addition tó the practical evaluation of Them. Compovnds from many sources will be evalvated in addition to those of special B
interest to the Several particular projects for the comning year have been B
discussed with the t representative and plans are
being made to carry these out in addition to any others which may
arise during the year, fhese particular projects are as follows:

1. Γo evaluate the effects of large dcses of LSD-25 in norinal human voluntcers.

2,  To cvatvate the threshold dose levels in humans of a particular natural product to B be suplied by tht This :evalvation presents difficulties of a nature which makes it a unique problem.

3. .Γo evatuate in human beings a substance which we now believe has the ability to counteract the inebriating effects-of ethyl alcohol.

Doree to: CHTIAL by cuprity cf: 16 75 Cate: ne 1977 E2 12E 7 175

O

Do:ng-aezãa to: COSFDEHTIAL by autyor1ty f: 187475 ċate:/June 2977 E2 1D2T: CL BY 187475

(3)

47-77

[PAGE 158]
E2 IUPDET; CL BY 187475 X PROPOSED BUDGET 1956-1957 tt Grant to Fmory University, Dept, of Pharimacology Carl C. Pfeiffer, Ph.D., M.D., Principal Investigator.

June 1, 1956 - May 31, 1957

Dores to: CFIDENTAL Ly 0101ty 0: 18747 date:pue 197- E2.IST:CL BY187476

[PAGE 159]
47-78

EMDRY UNIVERSITY B Crant

Departrent of Pharracology Dr. Carl C. Pfeiffer, Director

S:ngtry of Reçeiyts and Expenditures for the Period Jine i, 1955 through My 31, 1956

\* See attacbed schedules.:

Approvedt

Carl C. Pfeiffer, M.D. Project Director

Frory Univereity

Evell E. Bessent, C.P.A. .Controller

I have exazined and apprcved the subaitted expenditures.

C: EB cbil

Date: AUG 15 :856 TSS/Chezical Division

[PAGE 160]
47-78

: Depertoent ofPrareacology Dr. Carl C. Ffeiffer, Director

PERSONREL

Enployee

Position

Lab, lhid
Acst. Professor
ProfesBor
Student Recearch Asst, Stuicnt Research Asst, Technicisn
Regcarch Aspistant
Stuient Aest.
Instructor
Stüdent Aset.
Stuient Asst.
Stuient Aest.
Student
Stulent
Studeut
Instructor

Total Personnel

I have exanined and approred the subaitted expenditures.

Date:

AUG 151956

[PAGE 161]
expenditures., I bavo examined and approved the suboitted

cnief TSS/Chesical Division Dato: HUU 15 1956

[PAGE 162]
EMDRY UNTVERSITY

B OltGrant

Departzent of Pharnacology Dr. Carl\_C. Ffeiffere Director

EXPKNDAPL& SUPPLIES

Bub-total SIDNEY ZOTTUIEB Chief TSS/Cheaical -Division 14141

Date: AUG 15 195€

47-78

[PAGE 163]
FXFRNDABLS SUPFLIES

2

47-78

[PAGE 164]
STATEONT OF EXPENDITURES FROM ,GRANT AS OF JANUARY 31, 1956

BATANCE as of January.31, -1956 \$13,hh0.80

\*Supplenentary Equipnent allowance for purchase of Becksan DK-2 spectrophotorieter.

Gari b. Of

FILE 47

EORY UNIVERSTTY DEFARTVENT OF PHARVACCLOGY

[PAGE 165]
Ite

Total-Equipoont

I have examined and apprcvcd the subaitted expenditures..

Chier Daten AU6 15 1956. TSS/Cheaical Division

47-78

B EHORY UNIVERSITY r Grant Departoent of Pharncology Dr. Carl C. Pfeiffer, Director

[PAGE 166]
CENTRAL INTELLIGENCE AGENCY7OFFICIAL ROUTING SLIP.

SIGNATUREINFORMATIONAPPROYALRETURNACTION DIRECT REPLYCOMMENTPREPARATION OF REPLYDISPATCHCONCURRENCERECOMMENDATIONFILE

CONCIDENTIAL UNCLASSIFIED ATION TOP AND BOTTOM (SLNDER WILL CIRCIE CLAS

SECRET

[PAGE 167]
MEMORANDUM OF AGRFEMENT

The purpose of this mcmorandum of agreement is to set forth the mutual administrative responsibilities of the principal rescarch investigator and the sponsor. Therefore, it is mutually agreed that,

A. The principal investigator shall submit to the sponsor, at six month intervals, an informal statezent of expenditures of monies advanced for research activities. It is rcquested that the statenent te subaitted in essentially the following form:

Personal Compensation (Salarics. Subject Fees)

Equipzent

Supplies and Services

Contingencies

Overbead

B. It is understood that any travelexpenses incurred in the furtherance of the research progran will be accounted to the University in a manner consistent with its established practices and policies.

C. The prineipal investigator shall subnit to the sponsor seni-anriual reports on the technical progress of the rescarch covered by these funde.

D. Title to any permanent equipoent shall be retained by the University in lieu of higher overhead rates.

t1.6.P 111

Date: 7in 21./956

47-79

[PAGE 168]
Dr.
Director P2
Dear

As one of the favored recipients of grants fron theesd our basic chemical and pharmacological research progran for the past four years. It is our hope that our close relationship with the interests of theer vill continue since we ourselves are continuing to expand our-interests.in this field.

Since ry last letter.I have obtained an accurate quotation on the Nodel Dh-2Bccknan recording spectrophotometer and the items can be listed as follows:

\$7,175.00
1 Nodel DK-2 Becknan recording spectrophotoneter 290.00
1 "Tinc-drive" attachment for above 233.00
3.% Georgia sales tax TOTAL \$7,998.00

This equipment will be\_of extrene value to.us in our present research and is, I believe, a-basic-instrwnent for our present research Msfor nay years to come in our research at Fmory University.

Yours sincerely, Yours sincereiy,

Carl C. Ffeiffer, .D. Frofessor and Chairman

EMORY UNIVERSITY EMORY UNIVERSITY, GEORGIA

47-80

October 5, 1955

CCP:ba

WARNING NOTICE

SENSITIVE INTELLIGENCE SOURCES AND METHODS INVOLVED

[PAGE 169]
TO: A FRON: CTSS/CD sueJEct: Checke -Tranemittal of

FILE PFEIFFER .SUBPRCSECT

I hereby ecknowlcdee receigt of, the following:
Treasurerą Check No:on in the agount of \$8,000
forelscsn dtd 18 Oct. 55
Check No. 1n tho anount or 320 fore for on the 3, dtd 19 0ct, 55. B 2

please roturn\_ \_slgned copyllou) of thle recelpt

To
FORM NO. 36-66
MAA 194P

SICNATURE OF RECIPIENT Culsda 28 192s5 DATE RECEIVED

[PAGE 170]
JEMRANDUN FORI CHIP, PIRÁNCE DIVISIÓN

\*. Iss/Badgot Officor VIA ULA Subproject 47, Invoico f3, SUOJEGT A110tcent 6-2502-10-001

1. Imvoico 63 is ettached covering the abova subproject. It is regãestoi that payant to mads as follovsi amee payable

no caiara chec n co a  paable B to who in the asount of 88,000.00 and tho ssoand chsck for \$320.00. \$320,00. ecc/mhruii

2. Both checks ould bo forvariod to Chiof, Tss/Chodical Division, through TSS/Budget Officor, no later than 21 Octobor 1955. 1955. n af the total aprin

3. Thie invoico ropregents tho telenoe of the total aprint curreatly authorirol undor Sobproject 47. Bovovor, sinco it is enticipated that adiitlonal Fr 55 funds vill to obiigated undor this mitproject, the filea of Subproject 47 phouid rezsin open,

SIDIÉEY GOTTLIES Giof TSS/Chtcioal Divicion

Attachoentst Invoice & Certifications

Diatritationt Orig& 2 - 1drss 1 - Coxptroller 1 - TSS/YASB \~2- TSS/CD

A rss/c:(10 October 1955)

47-82

11 Cotobor 1955

[PAGE 171]
CERTIPICATIONS

(1). It is heroby cortified that this in Invoioo f3 applying to Subproject 47 of MuLiRA, that porformance is satisfactory, that services aro boing sccomplished in accordance with mitual agreements, that a dotailod agonda of tho payzenta anid roceipts-in on filo in Tss/c, that thi bill is just and oorrect and that payaent theroof bas not yot been made.

Chiof, TSS/Chenical Division

Datoi

(2) It' is heroby cortifiod that this Invoice applio to Subprojoct 47 of MKuLTRA vhich ves duly approvod, and that the projoct ia boing carried out in accordance vith the nomoranduaditod 13 April l953 fron the DOI to the DD/A, and tho oxtenslon of this authority in mubgequent mavoranda.

Dato!

Refasrch Diroctor

INVOICE

47-82

[PAGE 173]
KOMRADTH POR CAPSOLER

ATTENTIOA

Zinance Divisioa

BEJECT

AXULeA Sutproject 47, Additional Autborization No.2

Under the authority, granted In the memorandua dated 13 April 1953 froa the Dcl to tho to/A and tho extension of this authority in cubseyuent zoporands, Subproject 47 vaa previously appr vod. Under the eare authority an adlitioral pus of ts,320.00 has beea antborieed to cover the pubprojoot's exponees (therpby bringing to a total of \$33,875.22 fuda oblicatd during F1 56) to bo chargod to111ote0at62502-10-001,

SIDNET GOTTLDB Crtel IsS/Cbecical Divisioa

APIROVID YOR

OBLIGATED GP FUNDS

A

Eosearoh Director

Date: (

Diätributat

Orig & 2 - A8dre

1--TSS/0

617512-8.001

-1 - TSS/PASB

1 - TSS/SRB

2 - TSS/0D

1ss/cDe (26 Soptenber 1955)

47-84

26 Septasber 1955

[PAGE 174]
NEMPAIOUS FORI CRIEE, FINANCE DIVISION

MULTPA Sobproject 47, Involcs f3, A110tsent 6-2502-10-001

1. Invoico f3 is attached covering the abore sibproject. It is roquerted that payzant be mads as follovat B

Tvo earhiar's checks, drava oa
tothoASNERE
in the asomt of \$s,000.00 and the sscond chock for \$320,00. 2. Both checks Ehould bo forvardod to Chiof, Tss/Chealcal
Divieion, through TSs/Budgot Ofrlcor, no later than 21 Cetoter
1955. 1722 -uoun

3. Tie imvoice ropresants the balence of the total aount ourrantly authoritod wndir Subprojrot 47. Hovsyor, sinco it is enticipated that additionil Fr 56 funda vill bo obiigated under thie eubprojoct:tho riles of Sbprojoot 47should rezain open.

\- SIDU GONILIIS Chisf TSS/Checical Division

Attschaentst Invoico & Corticicitios

I CLETEY TNAT FUNDS AE AACARE

Diotributiont Orig & 2-Addrest00 1- Cozptrollor 1-TSS/FASB 2- TSS/CD CHECKE2223N 8334? RECEIVES208 4

il October 1955

47-85

[PAGE 175]
HEMORANDUM FOR: THE RECORD

SUBJECT : rKULTRA Subproject 47, Additiónal Authorization

1. Dr. Carl-ffeiffer, Professor of Fharnacoloey, Fnory University Medical School, is currently engaged in the-study of drugs sffecting the central nervous system. In addition, Dr. Pfeiffer also conducts a screening and evaluation program of gaterials of pharuacological interest to TSS/CD.

2. As a result of exhaustivo.conversations betveen TSS/CD and Dr. Pfeiffer,=it was felt that the-adnition of a Beckaan DK-2 Ratio Recording Spectrophotometer-to his present facilities would expedite the program snd contribute xaterially to the obtainnent of much needed data, For a more detailed application'of the instrument, see the attached proposal.

The estimated cost of this instruzent 1s \$8,000.00. The orrtr, service chargo of \$3,320.00. Charges should be made against Allotment  H four percent (\$320,00) must be added, aking the total figure

4. In accordance with the-Hemorandun of Understanding with Dr. Pfeiffer, the University shall retain title to any percanent équipaent. This is felt to be fully justified in view of the ieportance of the program in which Dr.-Pfeiffer is engaced on our behalf. Purchase of this instrument will materially increașe the production of the program. Additionally, in view of the nanner in which these grants-in-aid are handled, security considérations cake it undesirablo to attempt to provide the equipuent on a loan basis or otherwise retain title to it.

5. TheK orhas made errangetents for the retura' of unexpended monies to the Agency upon'conpletion of the prograe. This agreezent -is naintained in the records of the Fund.

Fosrd to: CRTAL ty 00ty : 157475 cate June 1977 E2 1TDET. CL E 187475

Dowa to by aority 9f/187475 cateJune 972 F2 1T: CL Y 187475

DRAFT/J

47-84

5 October 1955

1

[PAGE 176]
6. The presont program vith Dr.-Pfeiffer extends to 30 June 1956. It is anticipated that TSS/CD will desire-to continue utilizing the services of Dr. Pfeiffer for an indefinite period beyond that date, by-giving further erants. for research activities. to Dr. Ffeiffer, TSs/cD (through the yor will obtain Prior to'actually turning the funds for ths spoctrophotozeter over B a'statesent fron him to the effect that he is favorable to a con-. timing relationship vith thega

7. Dr. Ffeiffer holds a TOP SECRET approval for work under Project MULIPA.

Dato: 0ch. 6-19.55.

DownE-aded to: COFnEHIIAL by enthericy of: Ag475 cate: Juye 1977 E2 IVPDAT: CL BY 18/475

Distribution: Original Oly-TSS/CD

(26 Septeaber 1955)

Depsrozce COFAL ty/utho17 :18775) cato: J=-19/7 E2 1277: C B7 167475

[PAGE 177]
I was advised by your representative, -that one of our special research needs might be considered by thevegete aSpecificallywe need for research purposes in mental cisease a Eeckman DK-2 ratio recording Spcctrophotoneter. This would be used for the following purposes:

1) Routine assay for purity in those conpounds synthesized by w or those compounds which he isolates from 三 natural sources.

2) Use for nonitoring rapid chemical reacticns in biological systems.

a) The combination of convulsant acridone with deoxyribonucleic acid or ribonucleic acid.

b) The combination of pyridoxal phosphate with thiocarbolydrazide. --

c) The mõdification of epinephrine by schizophrenic serum - and cerebrospinal fluid. Heath reports a marked differcnce in light absorption with tine that is characteristic of schicophrenic serum.

The cost of this basic unit is\_\$7,h75.00, but with the vaver length hold attachment and salcs tax the totai cost would be about \$8,000.00.

Yours sincerely,

CCP:eJ

Carl C.Pfeiffer, .D. Frofessor and Chairran

Deincradedo: COFL by authority of: ys74p5 cate: Jund 1977

12 INFDET: CL BY 18 475

Dovncrae by authsrity0f 187475 cate:/June 1977 E2 1NDET; CL BY 187475

EMORY UNIVERSITY EMORY UNIVERSITY, GEORGIA

47-87

Pharmnacology Department

August 18, 1955

[PAGE 178]
6-2502.10-001

[PAGE 179]
47-89

INVOICE

Yor ssrvices

\$30,971.22

CERTIFICATIONS

(1) It is boreby cortifiel that this is Lovoico f2 applying to Sibprojoct 47 of MKuLiRA; that perfonance is-eatisfactory, that the sarvices are boing acoonplished in aocordancs with mitual agreonents, that a detailed agonda of the paymente and receipts is on file in Tss/co, -that-this bill is just and correct and that paymeat thoroof has not yet been mado.

Dater

Chief, TSS/Chenical Diviaion

(2) It is hereby certiried that thls invoice applies to Subprojoct 47 under MULiRA whioh was duly approvod and that the projoct is being carried out in accordanoe vith tho menorandun dated 13 April 1953 fron tho DCI to tho DD/A, énd the extenoion of this authority in gubsoquont rezoranda.

Dater

Research Director

SECRET

[PAGE 180]
RECEIPT

I heroby acknowledge rocoipt of tho folloving chookat

Tretsurars check Treasurers check Tregurera check Treisurors chock

in the aunt of \$29,803,10,47 in tbo anount of \$1,168,12,

all (four) checks drawn on the adatod 27 Septenbar 1955, and pejable to the

Deros Certs. 6, 1g

[PAGE 181]
MENRANDUM FORI CRLEY, FDNUNCE DIVISION

VIA 8 ISs/Budgot Offiçer

ULRA SabproSoct 47, Imdco #2 110tant-5-2502-10-001&6-2502-10-001

1. Invoice f2 ia attached covering the abore subproject. This is a final invoice. -It is requested that payment bo rade as followst E

Tvo cashlor's checks dravn on a ee bank, payablo to theee B , ono in tho anount of \$29,803.10 and tho socond for 81,163.12.

2. Tho checks should bo forvarded to Chief, TSS/Chemical Division, through TsS/Budget Osficer, no. later than 30 Soptembar 1955.

3. Tho tvo invoices covering thia subprojoct aggregate \$45,555,22, and mke uso of tho balancs of the YY 55 funde, plus tho Fr 6 funds obligated to dato under this subprojoot. Since it is expected that additional Fr56 funds vill bo obligated under this subprojoct, tho files on this projeot should not bo closod.

! CLLTIFY THAT FTOS ARE AVAILABLE:

224 Y303352
10-

Attachnntal Invoice & Certificationa

Dlstributionl Orig & 2 - Addressee 1 - Coptroller

CHECKEOUGIN THE AMOUNT DF. SORSO FECEIVEN. 580

C CHECKOARLIN THE AMOINT OF. SEN r8s/c  (13 Soptenbor 1955)RECEIVE.

19 Ssptember 1955

47-89

[PAGE 182]
47-90

Boory University

soorant

Diréctori Dr. Carl C. Preiffer

Report of Receipts ani Ependitmres for ths Period June 1, 1954 1ay 31, 1955

Receigta

\$24,035.00

#Sce attachcd scbedules

Carl C, Preiffer, M.D.// Project Director/

Exory Uaiversity

Evoll R, Bosent, C. P. A Coptroller

Apprcved:

Chief, TSS/Chezical Divielon

Dato:A31,170

[PAGE 184]
Jue 1, 195h - Hy 31, 1955

TRAVEL

[PAGE 185]
47-90

[PAGE 187]
47-90

[PAGE 188]
INSIRUCTIONS: Officer designations should be used in tho "TO" colurnn, Under each cominent a line should be drawn across sheet and each comment numbered to correspond with the number in tho "TO"cotumn, Each officer should initial (check mark insufficient) before further routing.This Routing and Record Sheet should be returned to Registry.

UNCLASSIFIED

[PAGE 189]
KOATURDUX FORt COGTROLDR

ArTklO8 Pinance Divigion

SUBJICT

ULIRA, Sabprofect 47, daditional Authorisation No. g1

Voter tho autbority granted in the nasorandaa datod 13 Aprii 1953, froa the DCI to the 1O/k and tho, extonsion of thia authority in eiboogueat pezoranda, Sbprojoct 47 was prevlonsly approvod. Oaier the mso authority en eaditional sua of \$30,555.22 has boca authorict to cover the subproject's expensos (thereby bringing to a total of (30,555,22 funds ob11catod during F1 56) to to chargedto 1110t0nt 6-2502-10-001

SIDNET GO1TLIEB Chiof TSS/Chaticsl Divieioa

APIROVED POR OBLIGAYIOA C FUOS

Datel

Diotrituticat Orig b 2 - Addrepece 1 - TSS/00 1-TSS/PAS8 1 - TSS/SRB A 2 -1Ss/0

asA

47-91

8 Lagust 1955

[PAGE 190]
Addendum to Sutproject 47

1. The purpose of-this addeodun is to set forth the mutual administrative responsibilitics of the coatractor and sponsor.

2. The above subproject represcat the research program of Dr. Carl Ffeiffer located at Emory University covering the period of 1 July 1955 through 30 June 1956.

3. The principal investigator shall subnit to the sponsor, at six ponth intervals, an informal statezent of expenditures of monies advanced for research activities. It is requested that the statement be subeltted in essentially.the following form:

a.  Fersonal Compensation (Salaries, Subject Fees),

b. Equipment,

c. Supplies and Services,

d. Travel,

e. Overhead,

f. Contingencies.

Also, th has requested Rnory University to submit to them a surary eccounting of monies received froa the Fund. They also requested the return of. any unexpended funds received under a grant fron the Fund.

4. Title to any permanent equipnent purchased by funds granted the University shall be retained by the University in lieu of higher overbcad rates..

5. It was mutually agreed-that documentation end accounting for travel expenses which are reimtursable by the University shall conform with the accepted practices of that Institution.

6. It was pgreed that technical reports reflecting the
progress of the rescarch program shall be submnitted at uutually
acceptable intervala... 1

PhBitetD. SIDNEY GOTTLIEB

Chief TSS/Cbenical Division

SECRET

MFMORANLUM FOR: THE RECORD

28 July 1955

SUBJECT:

47-92

Distribution: Orig. & 1 - TSS/CD

[PAGE 191]
I hereby certify receipt of Cashier's Check -No. U1789 in the anount of. \$584.00, drawm on the payable to the

Date: Git i4, 18s

MEMORANDUM RECEIPT

Sigrynd s

I hereby acknowledge receipt or the following:

CHECKIWOIN THE AMOUNT OF \$SZ.
RÉCEIVED.

47-93

[PAGE 192]
I hereby certify receipt of Cashier!s Check No, M191740, in the pmount of \$14.000.00, drawm on the ayable to the 4e B

Iipit 14, 1950

MEMORANDUM RECEIPT

TO: 5. FRON:

SUBJECT:

I hereby acknowledge rcceipt of. the following:

1055 1275 DATE

bebreyed17(ouq tas clb)

CHECK#LZ IN THE AMOUNT OF S/ RECEIVED.

algnod copy(lan) of this cocalpt

CERTIFICATE

[PAGE 193]
YETONDUR FORI CRIZ, PINANCE DIVISION

Iss/Dedget Orficer.

1Profoot MULaRA, Saborojoct No. 47. Invo1cof1, A11otcat 5-2502-10-001.

Iavoice Ho. 1 for Sibgaofect 47 of Frofect raupl is eltachod. Otber imvoices vill follóv later. It ls roquosted that peyuoat be mado by tuo caahlers checks, oco 1n t50 exxnt of 814,000.00, and o00 for \$53.00, peyrb1 13 to thoyThe chects chould bo sent to Calef, Ts/co Uhrouca Iss/bodçet Ciricer ty Volneaiay, 6 April 1955.

SIDIY GOTTLIB Chiof Iss/Cheaical Divioioa

Allachrontsi Invoioa & Cortiricatlona

Diatritationt Grig & 2 - Adiressee 1 - Cootroller 1- TSS/FASB : 2-TSS/CD

CHECK#LZ IN THE AMOUNT. OF \$/T RECEIVED.APR 13 1955 A

CHECKEOIN THE AMOUNT OF. SSO RECEIVED.

ICERTIFY THAT FUNDS ARE AVAILABLE: 187
OEUGATION REFERENCE NO. 5-2502-10-001
CHARCT TO ALLCTTT FO 4 - APR ENTO AUTHORIZING OTFICER

47-95

1 Apr11 1955

SECRET

[PAGE 194]
31 March 1955

B

CERTIPICATIONS

(1) It is hereby cortified that this is Invoice No. 1 applying to Subproject 47 of Project MuLiRl, that perforvance was satisfactory, that the services vero accoaplished in acoordsnco vith mtual agreemonts, that a detalled agends of the payuonts and receipts aro on file in TSs/cD, that this bill is just and correot and that payaent thereof hes not yet been made.

Dator

SIDNEY GOTTLIEB Chter,TSS/CD

(2) It is hereby certiried that this invoice applies to Subprojoct 47 under Project PxULiRA shich was doly ápproved end that the profoct is boing carried out in accordarce with the memorandun dated 13 Apr1l 1953 froa tho DCI to tho DD/a, and the extension of this authority in subsoquont mogorenda.

SECRET

JNVOICS NO.1

[PAGE 195]
ATTDTICA I Finsncs Diviaion SUBJECI 1 1 Profect , Supojoct 47

Vnder tha autority cranted in the Hozorenhus dated 13 Aprll 1953 fros the DCI to the DO/A, ard the exteasioa of this euthority in sabsequeat serorands, Suproject. 47 bas been pproved, end 15,000,00 of thé over-all Profect LA funds has toen obligated to cover tho tubproject's exponces, and should bo charged to 11lolzont 5-2502-10-001.

SIDRY COTTIJES Chlet TSS/Chezical Divipioa

APPROTLD FOR COLIGATIOS (Fr YVOSI

Distritutioot Crig &2=485700500 1-TSS/PASB 1 - TSS/SRB 2 - 1SS/cD

AVARAFLE

CHAGE TO AHCTMT a 1 5,750)-10. 01 T APR tRID

23 Yarch 1955

SECRET

47-96

T. ACNZRG OFCER

[PAGE 196]
Dosrcraded to: COPURA
by athorty of: 187475
¿ete: Jne 1977 1
E2 1M-1ET:CL BY 187475 SCOPE OF PROJECT

You will find enclosed a proposed budget for 1955-56 beginning with July1, 1955. With this proposed budget, we would be able to do all of the pharmacological;testing required by the ieluding the testing of new conpounds nade at this University and other coupounds which would be subnitted by you, and This would also include screening compounds:of sedicinal origin supplied by the Australian scientists and by a. When the pharmacological technician vas not busy ve would plan to have her-continue a careful study in mice and rats of CNS stimulantsWhich might antidote the acute effects of alcohol,

The travel budget may áppear-rather large but this is necessary in order to continue our testing program in man at the B

Doscsee to: C9ETIAL ty cyhority f: 187475 ¿ate Juno 2977 E2 IEZT: CL BY 187475

[PAGE 197]
SUBJECT : Project MULTRA, Subproject 47

1. The purpose of this project is to provide funds for the study of drugs affecting the central nervous system, and to screen and evaluate pharaacologically any other compounds which may be of interest to TSS/Cheaical Division.

2. The attached proposal indicates the extent of the investigations.that.will be carried out in these facilities available at Fmory University and provides for close cooperation with the work. at B

3. The funds for this project vill be transferred using the. Bm enc, as cut-out in the usual mánner,

4.. The cost of this program for a pcriod of one year beginning 1 July-1955 wil1 be €43,803,10 to which must be added four. percent (4%) fee to the gég naking the total amount \$45,555.22. At the present time \$15,000,00 is being comnitted, \$14,00 for the project and \$600.00 fee to the The balance of-the total will be comnitted at a later date

5. Both a and Dr.'Pfciffer are cleared TOP SECRET ty the Agency and are aware of tho sensitive nature of this work,

APPROVED FOR OBLIGATION OF. FUNDS:

APFROVED FOR ADDITIONAL .APIROFRIATJON OF 030,555.22:

Downeraded to: CENHCEHTIAL by anthoity op: 187475 Cate: June 1877 F2 1DE7: CL BY 187475

DRAFTNAO 23 March 1955

MEMORANDUM FOR: THE RECORD

Attachzent: Proposal

[PAGE 198]
by entyority ot: 187475 Cate:/June X977 B PROPOSED BUTGET 1955-1956 to, Emory University,: Dept. of Pharmacology E2 IPDET; Ch Carl C. Pfeiffer, Ph.D., M.D., Principal Investigator

\$30,300.00
2% OASB
5% Retirement) 2,121.00 \$32,121.00

-7,100.00
\$39,821.00
10% Universi
ty Overhead -3,982.10
TOTAL -\$13,803.10

\* At present paid from departmental funds \* Nex itens

TAL c7 187475 cate:/Jne 1877 E2 1DE2; CL BL287475

[PAGE 199]
2 1PDE: CBY 187475 BARE MTNIMUM BUDGET WITH NO EXPANSION OF PROGRAM

Salarics: 20\$7,000 Pescarch Tech, 3.6004 C 5,500 Research Tech. O) 3,000 Secretary (part-time) 100# Aninal man (50% time) 1,200 \* \$20,700.00

\* At present paid from departmental funds e» New items

[PAGE 200]
Enclosed you will find tuo copies of our report on the acompound which inclvdes a request for more of Compound No. RB h-99II. We are-sending this report at this time so that you can have more-of this compound made to continue our pharmacological testing. B

In addition, you will find enclosed a proposed budget fer 1955-56 beginning with July 1, 1955. With this proposed budget, we would be able to do all of the pharmacological testing required by the , including the testing of now compounds made at this Universityaand other corpounds which would be submitted AThis wovld also include screening con-When the phanmacological technician was not busy we would plan to have her continue a careful study in mice and rats of CNS stimulants which might antidote the acute effects of-alcohcl.

You will note that we also have attached a bare minimum budget which would profull-time at departuental cxpense onmproblems as well as a secretary part-tine and an animal man half-time.\_If\_the\_full expanded program is not reouircd by the , then ve would drop back to the bare mininum budget as outlined on the attached sheet.

IT Dorirrevisit we outlined our progress in several portions of our research program and if a formal report is reouired immediately by there 7 this can be provided. - We will of course have a detailed report at the end of June covering progress during the first year of suoport, of this research program.

The travel buiget may appear rather large but this is necessary in order to continue our testing program in man at the B

Yours sincerely,

m CCP:ba Énclosures

Gnle.Otiff Carl C. 'Pfeiffer, H.D.

DoT-ed to: ECSIDENTIAL by autortty f: y37475 cete:1977 E2 1Zi: CL E 187475

Downgrad tot CCBEHTIAL by outhority.02; 181475 cate: fune 177 E₃ IMDET; CL BY 187475

SEORET

ÉMORY UNIVERSITY EMORY UNIVERSITY. GEORGIA

(CLE47m 47-99

DIVISION OF BASIC SCIENCES IN THE HEALTH SERVICES Department of Fharmicology

March h, 1955

Dr. Sidney Gottlieb Scientific Roprescntative

Dear Dr. Gottlieb:

[PAGE 201]
INVOICE CEBIK LIST

MULTA Subprožect

At Date of Criginal Periad Tine Extended Allotcent Roount of Aunthorization Coverad To Rurter Ogligaticn

[PAGE 202]
T fro 47

Dote of Criefeel Ta: N- Allotant texcnd toEoedor
24M0)55\190ly56 15-3502-10-001 15000.00 Peredd Allotaent BAug1955 6.2502.10:001 30.55525 6Cet55 30J056 16:2502.10.001 8320.00 78m 56 6=1102-10=20.49.299.12 24. io.57 yr besiins 1-1 1-2501-10-0150.327.
619958 825021050130.08
#8 20 7My1960 I28qure'59 ilp 10une599-2502-75-902 0525.1c09-4902 Rlmnoo 9515477.92 50313.12

119/55 1584.00 416.00 21/13/55 30.971221 -0 3cofu/ss ..83.20.00 0 416/3/6 16,433.0432.866.08 2 11/55632866.08. 0 6 505716,185.933.571.90 71930p2195833571.90 0 t61921681 50,130.08 8309nly14511169100213342006 9123059133120.661 Cuthne59503350313.12 101240ug'4156.313.121 at1821 m1960 4 51477.92 /1 390/19101,477.92 G

47-100