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Dr. Harris Isbell, M.D., Director Addiction Research Center National Institutes of Mental Health U.S. Public Health Service Hospital Box2000

Lexington, Kentucky

Dear Dr. Isbell: :

I am forwarding under separate cover a 20 gm. sample of material that would appear to be of great interest to you. This compound iş reputed to be a very potent antagonist of barbiturates, The pharmacologist who has been studying its action claims that it is "infinitely superior to megimine". fe also states that "it is not a convulsant material, it has very low toxicity and that it acts by displacing the barbiturate from the site of action rather than by general stimulation".

. I bave more of this material on hand and it is quite readily obtainabie.I will be able to furnish more precise information later but at present the above information and the fact that the LDso in the rat is greater than 300 mg/kg. is all that I can tell you.

It occurred to me that if this material turns out to be as advertised for the barbiturates, it might be well to try it versus alcchol for soboring effects.

I hope that you are enjoying the Christmas Season and I shall be in touch with you soon.

Sincerely yours,

18 December 1956

A-248