[PAGE 3]
CERTIPICATION

Tis 1s to certify that we haw tho final sccoumting for grants made to HULTRA Sub-Project 7O. The accounting ia being retainod in isD vbere it nay be revieved by tho Cortibying Orficer upon request.

I further certify that satisfactory services bave been roceived and that to tho best of ry knovledga tha funds advanced far such services wero exponded for the purposo suthorized by tha project approval.

70-3

[PAGE 5]
CERTIFICATION

This is to certiry that va have the final accounting for grents ande to MaLTRA Sub-Project 70. The accoumiting is being ratainod in TD Where it may te rovieved ty the Cartibying Ofricer upou roquoat.

I lurther cortify that satiafactory services have been receivod and that to the beat of ry krovlodge. tho fuzde edvnced for such sorvices vere expanded for ths yupose authorized by the prcject approval.

[PAGE 7]
MENORANOUM FCR:TEE RECORD

SUBJECT

:A Subprojects 70, 91, 9 and 135

Sinco the coapletion of the audit of Project MarRA for tho period 1 Auvst 196o through 31 Jamary 1963, accountings have been roceived fronpca in the amount of \$93,677.50. th13 mouat 1e part of tho 153,117.93 balace to be accnted for by sus eaegantees at tho cnd of tho audit poriod.

Guborotect 70 incwred direct coets of \$2,518.34 and \$27,872.16 transferred from Subproject 9h, for a total or \$30,390.50. Subproject 94 incwrod exronseg of \$71,324.87, but tronoferrod \$4,165.71 to Subçrojoct 91 an1\$27,872.16 to Subproject 70, 1eeving s nat cost of\$39,267.00. It vs deoiéod to divert the fuia for Sudprojoct 13s to Subproject 91, thoreforo these corts were ircludxt in thes accounting froa Subproject 9l.

Inaazach as; 1) all four of tho subprojects had tho sane basic resenrch goal in aind, 2) the grcat length of time that has elapsed since the sranta were nade, end-3) tho difficuity in cettine acccuntirgs of any sort fran the grantee, it is recaaendel thot we facilitato this ratter by accoatire for tho balances es shown io tho Confidontial Rnda Division 760 account for thoso cubprajeots.AA

The abore bas boen concured in by m and Mt or tha Audit StAtt.

70-7

11. June 1964

[PAGE 9]
Costs - October 1, 1960 To November 30, 1961

[PAGE 11]
MCMORANDUH FOR: CHTEP, FINUADCE DIVISTON

VIA 1TSD/Budget Officer

UBJECTHaULTRA, Subproject Bo. 70Invoice Mo.4, A11otoent 1125-1009-1902

1. Invoice No, 4 in the amount of \$33,C8.12 covering the above subuoject 1s attached. However due to refunda of f1,h22,00 froa other projects (aa per attachmnts) payoent should be nads as folloves

Cashiér'a check in tho anount of \$30,390.50 E drava co aenomkave peyable to B

Cashier'a check in tha amount of \$1215.62, E drav co ams payabla to B

2. -Please forward the checks to Chier, TSD/Research Branch, through TSD/Budget Ofricer, no later than Thursday, 17 Novvaber 1960.

3. This is a final invoice. Howover, since it is enticipated that additional funds vill be obligated for this project, tho filea chculd cot be cloeed.

70-11

3 November 1960

[PAGE 12]
SECRET

(3) It 1s hereby certified that the prograa under Subproject 72 has been satiefactorily completed and returned unused funis. Hovever, subproject 70, vhich ie still contimuing also refunded money vhich was-left over at cutout froa previous grant. Therefore, it is requested that the anounte as shown below on Invoice No. 4 of subproject 70 ba credited to the subprojecta as ahowa belov.

Project Amount HOR Allotment

\$72 \$972.0027687-2502-10-001

170450.00 5710525-1009-4902

Chief, TSD/Research Branch

70-11

[PAGE 13]
CERTIFICATIONS

(1) It Is hereby certified that this is Iovoice No. h applying to Subproject 70 of MULTRA, that perforsanco ia satisfactory, that services are being eccoaplished in accordance vith mutual agreenents, that a detailed agenda of the paymonts and recoipts is filed in TSD/RB, that this bill is Just and correct and that paywnt thereof has not yet been made.

Chtef, TSD/Research Branch

Datei.

(2) It is hereby certified that this invoice applies to Subproject 70 under HuLRA vhich vas duly approved and that the project as being carried out in eccordiance vith the mesoraodum dated 13 April 1953 froa the DCI to the Do/A, and the extension of this authority in subsequent senoranda.

Rosearch Director

70-11.

For Services

\$31,606.12

[PAGE 14]
(3) It is hereby certified that the program urder Subproject 72 hes been satisfactorily completed and returned urused funds. Eovever, subproject 70, vhich is still coatinuing also refunded zoney which wes lett over at cutout froa previcus grant, Therefore, it is requested that the amounts as shoun below on Invoice No.  of Subproject 70 be credited to the aubprojects as showa belov.

Chief, TSD/Research Branch

Research Director

70-11

[PAGE 15]
TO:-TSS/OC

1. Date of Obligatioa:.

2. Purpose of Project: To conduct research to\_define mechanisms involved in production of involuntary sleep and related unconscious atates.

3.Progroos to Dato: Satisfactory

4. Explration Date: 31 September 1961

5.  Projoct Monitor:

FROM: TSS7&X RB

Roor XXoX West Outbullding, Exe, XX 119 2292

SaBORETT

TOR-SECBET

[PAGE 16]
MEMORANDUM FOR:THE RECORD SUBJECT : MKULTRA, Subproject No. 70

I. The purpose of this subproject is to provide funds for continuation of research on the "K" (unconaciousnesa producing) problem.

2. There exiats within the Agency a continuing requirement for bighly potent, quick-acting subatances that will render an individual helpless and immobile, preferably in an unconacious atate. It is anticipated that this program will provide fundamental information needed for solution of this problem.--The scope of thie researca program is intended to cover investigationa on the mechaniams in which certain drugs induce anesthesia or narcosis, elucidate the basic mechanisms of action iavolved and uncover and evaluate\_materials which bave value because of their potency, physical characteriatics, and biological activity.

3. Wbile information and materials available to date are inadequate to satisfy Agency requirements, there are model compounda which, because of their potency, biological activity, or

Dowegraded to: CONFDENTIAL by authority of: A dato: June 1977

Dotngracod to OFDETIAL by authorit of dato: Jae 1977 FOTHPDET; CL BY REST

TOP-SEORET

70=13

14 October 1960

TOP\_SECRE

[PAGE 17]
chemical characteristics, permit a predictioq that an adequate research program-stands a good chance of developing an understanding of the mechanisms and ehould result in the development of a material suitable for operatioñal use,

4. The as cut out and cover for this subproject. The necessary research and development will be conducted through will submit to the mary accounting of funde received frorn the foundation and will re turn any unused funds remaining at the conclusion-of the program. The estimated cost of the work for a period of one year is-\$31, 812.50. To this sum must be added a four per cent gervice charge for the amounting to \$1, 272.48, making the total cost of tbis program \$33, 084.98.

: 5.Total cost of the project for one year will not exceed \$33,084, 98.Chargea should be made against Allotment No. 1525- 1009-1902.

6. It is not anticipated that any permanent equipment will be required for this program.

7. Documentation and accounting for travel expenses which are reimbursable by  will conform to the ac-

Do to: CONIDENTIAL by auoitof: cates Juna 1977 V; CL B  A

Domgracsa to: CONFIDENTIAL by.auhoityat: date Juno 1977 E IFDET; CL BY \~

TOP-SEOREM

70-13

TOP-SECRE

[PAGE 18]
cepted practices of that organization,

8. The requirement for a semi-annual informal accounting on the part of the investigator is waived.

9. All personnel connected with the planning and monitoriog of results of this program possess TOP SECRET approvai. The pro. ject is unclassified after it leaves the

APPROVED FOR OBLIGATION
OF FUNDS: Date: Research Ditector

Attachment: Proposed Budget

Distribution: Original only

CONFBEHTIAL of: 1977 2 1EOE; CL BY

70-13

[PAGE 19]
RESEARCE-PROPOSAL

It is proposed to. continue basic research-on-sleep and unconsciousness along-the lines laid dcwn-by-the\_Sponsor and his technical consultants.The principal investigator will exert his best efforte in conducting research to define the mechanisms unierlying production of involuntary:sleep and.to differentiate the mechanisms involved in the production of\_this for of unconsciousness from other states cf unconsciousness or re:ated behavior Because of the generally poor-atate of knowledge in this area of work and furthermore, because of the peculiar requiremonts of the Sponsor as distinguished from the usual medical requirements, it is underatood that the major framework of the\_research design for this work will be provided by the Sponeor.

Reports will be rendered on progress cf such stulies and 1 investigations ag significant advances are accomplished.

WARNING NOTICE SENSITUT LANSENCE SCESTT MCDS INVOLVED

[PAGE 20]
ESTIMATED BUDGET

[PAGE 21]
Financial Statement June 1, 1958 to July 1, 1959

Expenditures :

Wages & salaries 19,800.00
Equipment 1,543.86
Supplies -1,048.61
Overhead 3,134.94

25,527:41

Balance July 1, 1959 (Deficit )

(\$ 105.41)

Accountant

I bave exasinad and approved tho ouceitied expenditures. 4

19715

[PAGE 22]
Grant for: Research on Sleep and Uncongciousness

[PAGE 23]
SECRET

(When Filled In)

No.sl4

Cost Account 1125- 1009-1902

Object Class

70-1.4

[PAGE 24]
14 Octodor 1960

MEMORANDUM FOR: COMPTROLLER

ATTENTIONI Flaaace DivisloQ

SUBJECT 1MKULTRA, Subproject No. 70
Additional Authorization No. 3

Under the anthority granted la the memorandam dated

13 April 1933 frem the DCI to ths DD/A, and the exteasloa os

this authority in aubaecueat memoraada, Subproject 70 baa

been approved aod \$33,084.98 cf tho over-all MKULTRA pro-

jact futida hae been obllgated to covor the aabproject expenges.

Thle obligatlon of fands ebould be charged to Allotmcot 1525-

TSD/Research Branch

APPROVED FOR ODLIGATION

Datoi\_

Distributioal

Orig.& 2 - Addressco

1- TSD/OC

X- TSD/FASS

'2-TSD/RB

TSD/RB/ONR(14 Oct. 60) SEORET

SEORET

70-15

[PAGE 25]
27.January 1960

MEMORANDUM FOR:THE RECORD

SUBJECT: Action on MKULTRA Audit Exceptions TSS/CD

SP#70

The \$450.00 balance, expenditure of which was unaccounted for in this folder, is being held in thewo w asss account and will be returned.

18 July 1960

Recent technical developments and the continuing availability of adequate reaearch facilities, along with tbe increased presaure on the production of a practical end product related to this project, indicate-that there will te a continuing and probably increased effort. in this area. In view of this, it has been decided that the funds mentioned above will be retained for:use in connection vith the next re-financing of this project,: rather than being carried over to some other aubproject by the usual procedure. This project will, as-presently scheduled, be refinanced on-a-continuing basia in October 1960.

SECBEL

70-16

[PAGE 26]
MEMORANDUM FOR: THE RECORD

SUBJECT :MKULTRA No. 70

The following endorsed and cancelled. checks (photostat copies) issued by the applicable to MKULTRA No. 70. They are for salary expenditures on this subproject and are held in lieu of formal receipts which were not requested, They does normally require receipts for aalary checks which endorged, cashed,

or deposited constitute acknowledgment of payment,

fAC-1 Aug 13, 1957 \$1500
#105 Oct 1, 1957 \$1500
#114 Jan 2, 1958 \$1500
#122 Apr 1, 1958 \$1500

Total

70-17

30 October. 1959.

[PAGE 27]
Gentlemen:

We are pleased to be able to transmit to you the -folloving funds:

Cashier's Check No. A80635 dravn on the for\$30,900.00.

Treasurer'a Check No. 242235 drawn on A 4081or1,236.00

These funds represent a contribution for the use of your directors iù carrying out the very vorthvhile research goals of your organization.

Bncl.

70-18

September 30, 1959

Yours, truly,

[PAGE 29]
MEMORANDUM FOR: CHIEF, FINANCE DIVISION

VIA: :=TSS/Budget Qfficor

SUBJECT :MKULTRA, Subproject 7O, Iavolce \$3 A11otmnt 0525-1009-4902

I. Lavoice f3 coverlog the above subproject ls attached. Pavment ehould be made as follows:

Caahler's check ln the amopnt o1 \$30,900.00. drawn on a Smmns Gny payablo toda

Canbler'e check in the anerbt of \$1, 236. 00, drawn on a 5e02g e payablo to

2. Please forward the chocks to Chlef, TSS/Chemical Divliloo, through TSS/Budget Officer, co later thaa Wedneaday. 7 October 1959.

3. This is a flnal lavolce. However, since it la aoticipated that additloaal funds will be obligatad for thls project, the flles should got ba cloeed.

70-19

23 September 1959

[PAGE 31]
CERTIFICATIONS

(1) It lo hereby certifled that this ls Invoice §3 applylag to Subproject 70 of MKULTRA, that performance is satisfactory. that servicee are being accorpllehed in accordance with mutual agréements, that a detailed agenda of ths paymente and recelpta is flled in TSS/CD, that thie bill is just and corzect and that payment thoreof bas not yet been made.

Chief. TSS/Chemical Division

Data:

(2) It ls boreby certiflad that thia lavolce applles to Subproject 70 under MKULTRA which was duly approved and tbat the project is belog carrled out ln accordance with the memorandum dated 13 Aprll 1953 from the DCI to the DD/A, and the oxtension of thls authority la aubsequent memoranda.

INVOICE

70-99

For Servicee

\$32,136.00

Date:-

Rosearch Director

[PAGE 32]
1. The purpose of this gubproject is to provide funds for a continuation of research on the "K" (knock-out) problem.

2. There exists within the Agency a continuing requirement for highly potent, quick-acting substances that will render an individual helpleas and immobile, preferably in an unconscious state. It\_ia anticipated that thia program will provide fundamental information needed for aolution of this problem. The acope of thig research program is intended to cover investigations on the manner in which certain-drugs induce anesthesia or narcoais, elucidate the mechanism of actlon of such compounds and uocover and evaluate materials which have potential value because of their potency, physical characteristics, and biological activity.

3. Wbile information and materials available to date are inadequate to satisfy Agency requirements, there are mcdel compounds which, because of their poteucy, biclogical activity, or chemical characteristics, permit a prediction that an adequate research program standa a good chance of developing a material suitable for operational use. -B

DRAFT 18 September 1959

MEMORANDUM FOR:THE RECORD

SUBJECT

[PAGE 33]
cut out and cover for this subproject. The necossaxy research and development will be conducted by who will submit to'thed summary accounting of funda received from the foundation and will return any unused funds remaining at the conclusion of the program. The estimated cost of the work for a period of one year is \$30, 900.00. To this sum muet be added a four per cent service charge for the amountiug to \$1, 236. 00 making the total cost of this program \$32,136, 00.

5. Total cost of the project for one year will not exceed \$32,136.00. Charges should be made against Allotment No. 0525- 1009-4902.

6. It is not anticipated that any pormanent equipment will be required for this program.

7.Documentation and accounting for travel expenses which are reimbursable by will conform to the accepted practicee of that organization, B

.8. The requirement for a semi-annual informal accounting on the part d the principal investigator\_is waived.

[PAGE 34]
9. All personnel conuected with,the planning and monitoring of results of this program possess TOP SECRET approval. The project ie unclassified after it leavea thed

APPROVEDFOR OBLIGATION OF FUNDS:

APPROVED:

Date:9|2159

Chief TSS/Chemical Division

Attachment: Proposed Budget

Distribution: Original only

Dovasrdedto: CONFIDEATIAL by thoty of: dat:Jo 1977 ESITET; CL BY

[PAGE 35]
PROPOSED BUDGET

[PAGE 36]
MEMORANDUM FORI COMPTROLLER

ATTENTION : Fiaance Dividioa

SUBJECT MRULTRA, Subprojt 70 , idlctiond Anthouzatien# 2

Uader the aathorlty Sranted in the mamorandum dated

13 Apzil 19S3 (rom the DCI to the DD/A, and the axteaaloa of

thio euthority la subsoquent menaoranda, Subproject 7o has

baen 4ppreved tad \$32, 136. 00 of tha over-all MKULTA project

funde bas been obllgated to cover the gubprojact expenses. This

obligation of funde should be charged to Allotment 0525-1009-4902.

TSS/Chemlcat Division

APPROVED FOR OBLIGATION OF PUNDSE

Researcb Director

Datet

Dietribution: Orig & 2- Addraeeeo

1- TSS/OC 1-TSS/FASB 2-TSS/CD

18 Septembor 1959

[PAGE 37]
Financial Statement July 1, 1957 to June 30, 1958

Funds received

\$15,390.00

Expenditures:\_

Salaries \$10,164.54

Animal-Houses 2,731.19

Geceral Supplies 567.88

Travel and Honorarium 85.00

Overhead 1;890.00

15,438.61

Balance.June=30, 1958-(Deficit)

(\$ 48.61)

Assistant-Controller

I have-examined and approved the.submitted expenditures.

Date: /59

To-20

OFFICE OF CONTROLLER

[PAGE 38]
MEMORANDUM FOR THE RECORD

SUBJECT: Request for Authorization of Change, MKULTRA #70

1. Authorization to use outside laboratory facility requested by letter 9 June 1958 from received-1l-June 1958.

2. Verbal authorization granted (by telephone) 12 June 1958. 2

WARNING NOTIGESENTIVSANTELAIGELDGSOURCPS AND METSODSNVOLVED

0

70-23

[PAGE 39]
In view of the fact that s. moving from iown to in the first part of the coming year, and the resuitant limitation of space and curtailment of activities, it is requested that authorization be given by you to the Foundation to have the second year of -research activities on the part of be plàced in an outside laboratory faci--Hity. C\

A letter from requesting the change is attached hereto. for your perusal, There are no objecttons on the part of the Foundation to the chang.

Kindly notify us at your earliest convenience of your decision.

B

June 9,1958

[PAGE 40]
MEMORANDUM FOR: The Record

SUBJECT : Authorization for Facility Change, MKULTRA #70

1. By letter dated 5 June 1958 from ay rcquest was made for permission to use outside facilities to continue gecond yearof research.

2.: Verbal authorization for requested change in facility was granted 9 June 1958.

whoun reonge INSITIVE INTELLIGANCE SOURCES ANP METVODE INVOLVED

70-25

[PAGE 41]
Dear Sirs :

As you know, the is moving fromé down to i the early part of the coming year. On a phasing out schedule, many of the Departments, fncluding Neurology, are to commence moving of faculities and personnel starting January 1959. You can not imagine the chaos and turmoil already in progress. For all intent and purpose, I would say that any productive work would not be forthcoming for the\_next two, if not three, years.

Since the coupletion of the new medical school is behind schedule, it would be difficult to predict when adequate space will be available for all the different departments. It has already been determined that doubling up of both research and elinic space will be the order of the day,

As an interim procedure, many of the research sections have looked to the use of outside laboratory facitlities to fill the gap that will exist at school. The University recognizes the urgent need'and necessity of outside facllities\_ and will authorize the use of same.

In order to conduct my activities in a smooth and orderly fashion, I would like pernisston to place my second year of research in an outside laboratory facility, namely,tda Preliminary discussions with the Dean of the Medlcal School show no objectlons on his part to the use of the facility.

If the relocation of the research project is accecptable, please notify me at the earliest opportunity, Your support has been greatly appreciated.

Assoclate Clinical Professor

70-26 B B B

June 5,1958

[PAGE 42]
29 ay 1958

Be are pleased to be able to tranemit to you the folloving fudst

Check f209-333085 drava on for \$25,422.00

Check re 12465 dravn on E for\$945.24.

These funds represent a contribution for the use of your directore in carrying out the very vorthwbile research goals or your organizstion.

Yours truly,

[PAGE 43]
MEDCRANUN PORI CAIE, FINANCE DIVISION

8 T86/Dulgst ficer

, Subprojet 70, Lavoice2
A110tmnt 7-2502-10-001

l. Inroice No. 2 coverina ths abore subproject is attachei. Paorat should be ssde ae follcve:

Cabierch t ,0

Ceshier's chock in the eoount of o5.2 -B

2. Pleese formrd the checks to Chief, Tsg/Chaaical Divislon, through Isa/Budget Officer, no latar then Wedneaday, 28 May1953.

3. Thie invoice represente the total asount currently euthorised undar Subproject 70. Bovever, since it is antlcipated that adiitiocal funde will be cbligated for this project, the files shculd not be closed.

TS8/Cbeaicel Division

稱 Attachzente: Invoice snd Certifications

TCECTIFY THAT FUNOS ACS AVAILASLE GHGATONRRE26 10 402502700

Dietribution Orig à 2 - Addressee Orig à 2 - Addressee /1-TSS/YASB /1-TSS/YASB 2-TS/CD 2-TS/CD

E AMOUNT-OFS.2S

70-28

13 Nay 1958

[PAGE 44]
70-28

INVOICE

Por servicos

\$26,367,24

CERTTFICATTCS

(1) It is heraby certified that thie is Invoice f2 applying to Subproject \$7o of MaiRA, that porformance is satisfactory, that servicee are being sccoaplished in sccordance with wutual sgreements, that a detailed agonda of the poyoenta and recoipts is on file in T8s/CD, that this bill is fust ani correct ani that paynent thersor has not yet boea made.

Chier, Tss/Cocalcal Division

Deter :

(2) It io hereby certiried that this invoice applies to Subproject f70 of eLTRA wich vas duly approved, and that the project is being carried out in eccordence vith the pomorandum dated 13 April l953 fron the DCI to the DD/A, and the extensioo of this suthority in subeequent memoranda.

Fescerch Director

[PAGE 45]
70-29

28 August 1957

Gentlemen:

Vo are pleaned to be able to transmit to you the folloving fundst

Check f65313 drevn oo the 10r \$21,8h0.002422.
Check f427/4 drawn on the for\$945.24 945.24

These funds represent a contribution for the use of your directora in carrying cut the very worthwhile rosearch goals of your organization.

Youre truly,

SUBPROJECT 70

[PAGE 46]
September 11, 1957

Thie is to scknowledge the receipt of the following checks :

Check #65313 drawa on the for \$21,840.00

Check #42774 drewn on th tor \$945.24

Your generous contrlbutlons are greatly ppreciated. The funds wili be utülized by our Board of Directors in furthering worthwhlle research projects in the fleld of medical eciences.

IMeTRUCtiONS.-Sho name. addreee and number of arriote balo, Coaplece"Inartuctiona To Deiiverins Eapiayee on other side. when apphicabie.-Moiaten Sumaied mactand securely attach so back of articie. En-Wftont Ol«Eticie RETURN RECEIPT REQUESTED.

PENALTY POR PRIYATE USE MO AYOH PAYKENT OF POSTAGE SOR

[PAGE 47]
MEMORANDUM FORI CHIEF, FINANCE DIVISION

TSS/Bedget Olflcer

SUBJECT

MKULTRA, Sobpreject 70, Lavolce /1
A1lotmept 7-2502-10-001

Iavoice fi covaring the above subprojact ie attached. Other inveices will follov. it le requested that paymeat be made ae followe:

Cmabier's check la the amount of \$21,840.00 drawa payable tou

Caghier's check in the amount of \$945.24 drawa payable to -B

2. The chack should be forwarded to Chief, TSS/Chemical Divieloa, through TSS/Budget Offilcer, no lator thaa Friday, 18/02 655/3 16 August 1957.

Acting Chiel TSS/Chemical Divioloa

Attachraenter Involce and Certifications

2 2765 2:3503-10-001-

Dletrlbution: Orig & 2 - Addreeseo 1- Comptroller

TSS/FASB 2:TSS/CD

2 Auguat 1957

[PAGE 48]
For torvices

CERTIFICATIONS

(1) It is hereby certifled that this is Invoice #l applying to Subproject f7O of MKULTRA, that performance is gatisfactory. that servicen are being accompliehed in accordance with mutual agreements, that a detailed agenda olthe paymenta and receipte ie on file in TSS/CD, that this bill is juet and correct and that payment thereof has not yet been made.

Acting Chief, TSS/Chemical Division

Date:

(2) It is horeby cortified that thia invoice appllea to Subproject f70 of MKULTRA which was duly approved, and that the project le being carried out in accordance with tbs memorandum dated 13 April i953 from the DCI to the DD/A, and the extonaion of thie authority in aubsequent memoranda.

INVOICE

\$22,785.24

Research Director

[PAGE 49]
MEMORANDUM FOR: THE RECORD

SUBJECT:\_

Assignment of One IBM Electric Typewriter\_to MKULTRA Subproject 70

1. One IBM electric typewriter, No. I51957 (reclaimed from MKULTRA Subproiect 57 upon its termination on.3l May.. 1957) has been assigned for use to MKULTRA.Subproject No. 70,

2. Receipt is hereby acknowledged of one typewriter (lBM Electrtc) No. 151957 on 1 June 1957. The typewriter will be physically located in the@dm -B

Branch-I TSS/Chemical Division

Distribution: Orig & 2- TSS/CD

TSS/CD: (4 June 1957)

70-32

4 June 1957

[PAGE 51]
MEMORANDUM FOR: THE COMPTROLLER

Flnance Divieloa

MKULrRA Subproject 70

Under the sutbority granted in the Memorandum dated 13 April 1953 from the DCI to the DD/A, and the extenslon of tbla authority in subsequeat memorands, Subproject 70 has been approved. and \$49. 152.48 of the over-all Project MKULTRA funds bave been obligated to cover the subproject's expenses and should be cbarged to Allotment 7-2502-10-001.

SIDNEY GOTTLIEB Chlef: TSS/Chemlcal Otvision

APPROVED FOR OBLIGATION OF PUNDS:

2703 SHN10 7.35011001

Dlatributlon: Orig & 2 - Addressee

1- TSS/0C
TSS/FASB
1--TSS/SRB
2-TSS/CD

TSS/CD.(1 May 1957)

1 May 1057

[PAGE 52]
1. The purpose of Subproject 70 is to initiate research work on the "K" (Knockout) Problem at the

: 2. The scope of the research program is outlined in the attached research proposal. There exists'within the\_Agency a continuing requirement from the Operating Divisions for a substance or substances that will render an individual or animal helpless and immobile, either consciousiy or unconsciously, until definite control measures can be instituted. It is envisioned that this program will supply some of the answers so sorely needed.

3.. It is expected that will monitor and direct and actively participate in this project as principal investigator from the where arrangements have been made-for his appointment as an

4. In view of the magnitude and scope of the project, it is
felt that a two-year period is required for realization of some answers
to this intricate and complex problem. Therefore, a two-year re
search proposal is attached. The cost of this program is estimated
at \$21, 840.00 for the first year; \$25, 422,00 for the second year; for
a total of \$47,262.00. To this sum must be added \$1, 890.48
representing a four percent service charge to the making the total amount for two years \$49, 152.48.
The Foundation will function as cutout and cover for this grant, The
cover title\_of the project is
and is presumably being supported by a research grant from the Foundation.

5. The total cost of the project for a period of two years will not exceed \$49, 152.48. Charges should be made against Allotment 7-2502-10-001.

Downefraded ONFIDENTIAL A
by Mthorh
dq e: Ju INFD BY

MEMORANDUM FOR: THE REGORD

SUBJÉCT:

MKULTRA Subproject 70

[PAGE 53]
6. The Foundation has requested the University to submit a summary accounting of monies received and to return any unexpended grant funds at the end of the project year.

7. Title to any permanent equipment purchased by funds granted the University shall be retained by them in lieu of higher overhead rates..

8.It was mutually\_agreed that documentation and accounting for travel expenses which are reimbursable by the University shall conform with\_the accepted practices of that institution.

9. The requirement for a six months' informal accounting on the part of the principal investigator is waived.

10. is cleared through TOP SECRET and is aware of the true purposes of the program. Also, he has agreed to comply with the requiréments of the Memorandum of Agreement.

Chief, Branch II TSS/Chemical Division

APPROVED FOR OBLIGATION Approved: OF FUNDS:

Date: : 3133

Attached: Researchproposal

Distribution:.. Original only

70-34

[PAGE 54]
BY There exists within the Agency a continuing requirement from the Operating Divisions for a substance or substances that will render an individual-or antmat helpless and immobile, either consctously or unconsctously, untit definite control measures can be instituted, The instances and situations where such an advantage can be utilized are too numerous to be mentioned. Within TSS/CD this problem has been designated the "K" (Knockout) Problem.

From various sources (scientific literature, TSS/CD projects, etc.) numerous bits of disjointed information have been accumulated in this area. Many provocative suggestions were raised that warrant further investigation. To date, there are no active projects or individuals specifically established by TSS/CD for the investigation of this problem, Therefore, this project was designed for the purposes of centralizing all efforts in this field, consolidating the existing data, and initiating active research on some of the many existing provocative suggestions.

The project will be established within the Initially, the research \_activity will be divided as follows:

I. The Experimental Evaluation of Sedative Agents

A. Tick Paralysis

Certain species of ticks (genus Dermacentor) have been incriminated in a-clinical\_syndrome commonly referred to as "tick paralysis". This syndrome occurs in both man and animals, It results from a tick bite, and is characterized by ascending flaccid raralysis of the musculature. Removal of the tick is usually followed by complete and rapid spontaneous recovery. The etiology of tick paralysis remains obscure. The disease is believed to result from the inoculation of some únidentifled tick-generated, toxic substance which appears to be neurotropic.

As a by-product of Project Naomi, a sizeable amount of this neurotropic toxic substance is being isolated.-The development and experimental evaluation of this substance as a sedative agent wili be carried out within the scope of this "K" Problem prōject.

THE "K" PROBLEM

70-35

Downg aded to: CoFIOENTIAL by thorit 4 cate: June 197 E IEDET;C BY- A

[PAGE 55]
BNarcotic Eftect of Fatty Acids

As a result of preliminary investigations carrled out within MKULTRA Subproject 57 (terminated 3l May;1957), it was found that the parenteral administration of fatty acids-induced-a state of unconsciousness in-small animals which when examined by electroencephalogram techniques turned out to be similar to ordinary'sleep. The length of narcosis varled with the dose of the fatty acid administered. Of extreme interest is the fact that fatty äcids, unlike other narcotic agents, are normal constituents of the diet and body tissues.

Investigation will be carried out on:

1. Mechanism of fatty acid narcosis,

2. Effective modes of administration other than parenteral,ie. oral, respiratory,

3.Additional fatty acids - short or\_tong chain, saturated and unsaturated.

C. Assay of New Sedative Agents

The methods usually employed for the assay of sedative drugs are not specifically directed toward the evaluation of sedative activity although all methods utilize one or another of the characteristics of "sleep" as the criterion of effect. In the absence of a pharmacological definition\_of sleep, evaluation of sedative action has been conducted at difterent levels of this state, ranging from sleep itself to hypnosis, and even to general anesthesia. It is apparent\_that the criteria or endpolnts employed in such evaluations have, either overshot the target of sedation or have not bracketed it adequately. This then leads to a state of general confusion in the evaluation of the newer sedative agents.

To utilize effectively the sedative agents available, both tested and untested, requires the development of a systematic method of testing and systematic method of characterizing the drug, both in terms of the symptomatology produced and in terms of describing potency in producing given effects by means of standardized and valid statistical. procedures. An objective report:will be designed that will attempt\_tostandardize the reporting procedure-for all TSS/CD research

Downgraded to: CONFIDENTIAL by authority of:w A date: Juno 1977

DoTograde4 to:.CCNFDENTIAL by authority.of: date: Juño 1977

[PAGE 56]
E2 INPDET; CL BY projects employing animal experimental procedures.

iI. Incapacitating Agents

As a result of animal testing procedures, a number of centrally acting skeletal muscle relaxants have been found. Several are or have-been evaluated clinically in man with varying results, Occasionally, clinical reports appear claiming that certain pharma cological agents that have minimal muscle relaxant effects in some experimental animal preparations prodúce dramatic rellef of spasticity in man. Clinical impressions are the usual criteria of effectiveness

There exists within the. the opportunity for clinical evaluations of some centrally acting skeletal muscle relaxants on the therapeutic relief of spasticity in man.

by authority of: date: Juie 1977