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WEPmAIOM OR Guef, Netleal Staf

cUJ:CT: Alcnhol Antagonisto

1. inforation would bo anpreclated regardin, tho availability and the effootivenoas of alcohol antagonists that misht be proparod in liquid, pill or capsulo forn for

2. Focontly, when intorest in this cbjoct. dovolosed, a non-professionai survey of the problon, vhich is attadied, rovaaled four possible appmnches to tho subjoct wiich apparently have not beon exhnustivoly studiod.

a, Unc of aleohol antaroniots boforo drinkinc.

(1) Bonsodrino.
(2) Perritin.

b. Adaorotion of aledhol in Ihe ll oolive tract.

(1) -Carcoal

(2) Aluimua gal preparations.

c. linavy catin: af atorches and rumss bofore and. uue drini.

d. Accalezatod nicool o idation (elinination).

(1) nsyme adjuvanto, sich as nicotinic acid.

3. Tour opinkons and sn gestdoas on thiic aahyioct would bo approciatod at yuir sarllaat convenlonco.

Assistnnt Diroctor G 1

Attachmentt 1 "Intoxication, /Icohol Absorpbion anl Antaronioto"

Orig. in TG/ 26 June 1952

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UUNJTCT: Alcohol Antagonists

1. Your nenorandu dated 19 August 1952 concerning nlcchol antagonists has been roviewod with considerable intorcst, Fron this rovicu it nppoars that there is no simplo substance or coanound available at the prcsont tine u' ich is aoquate to sorvo the opsrationnl nceds of our personnel.

2. Tho corollars problon which hao occurrcd to this officc. as a rosult of rovievins your nenorandr, involves the dosirability of havinc available pome substanco which could be inserted into a drink; to accelerate tho effcct of alcohol. It would be of considerable oporational value to if we had available à substoncs which could effectively inhilit the offecto af alcohol as well ao another substanco which could be insorted in a irink to accelerato the offccts of alcohol. The utility of such substances is balioved to bo sufficiont to juntify enbarking on. at lenst soe nedicnl research to datemine the Ioeasibility. of developing such substances.

ACTION

3. It is rogucstod that tho Nodical Pivision discuss this ratter with Ors and detemino which caponent should undertake such resoarch and doveloprent progra and advise this office. Cpon rorcipt of such advice a more detailed requirenent will bo lovied apon Uho pproprinte component if necessary or advisable.

cCI OTS, Attn TGS G weic men

ATTITION:

710,2, 67,01 P.4404

IURADTI FOR: Tho ledical Division