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l. The basic research concept is well planned; however, the following suggestions coe to mind:

a. I do not recommend the exclusive use of dogs--actually l,100 in number. During the past 5 yeara, there has been considerable research on electroanesthesia in the U.S. with animals of all kinds. In spite of this effort, little is applicable to electro-anesthesia in the human.

b. Preliminary iovestigations might well begin with the dog in order to develop technics peculiar to inducing electro-anesthesia and in monitoring the condition of the animal during and after passage of electrical currents.

c. Following the use of a reasonable number of dogs--perhaps 100--the research should be directed to the rhesus monkey.where the subject can be used repeatedly day after day.

d. As soon as expedient, the observations should be transferred to a few chimpanzees, which, like monkeys, can be uBed repeatedly, varying the electrode placement and nature of the electric currents with continuous monitoring of the animal.

shmed be viga e. Finally, concurrently.with observations on the chimpanzee, human subjects may be paid volunteers or perhaps patients in a psychiatric ward of a hospital

2. Comments re numbered paragraphs in proposal ara as follows:

a. I.A, - I do not think it necessary to study all poasible variationa of alectrical currents. The most promising values of frequency and intenaity should be followed up as suggested by the present observatious and published results of other investigators in this field.

b. I.B. - Placement of electrodes may be very important and certainly will differ with the species of animal. The intensity of the currents will vary probably with animals specias.

c. II. - General anesthesia would be more important than local effects. Again it should not be necessary to perforn major surgery in order to aacertain the extent of the anesthesia induced. Why ahould drugs and O2 not be used ia the studies with dogs?

13 June 1966

MEMORANDUM FOR FILE

SUBJECT: Project Proposal by Dr.

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IV.- Implantation of six chronic electrodas within the brain to caitor tha electric current, etc. may well influence tha current distribution the brain. Perhaps models could be used. for these studies. f. V.B.- Why not consider electromyographic recordings in case the motor cortex is stimulated, Also, electromyography should be of value in determining the relaxation of muscles desired in surgery.

g. V.E.:- Methods for determination of the depth of anesthesia are presently unsatisfactory, Pinching the ear is used frequently with tha monkey g.:V.H.- Post-operative observations in some caaea should be extendad for several  days.

h.V.J.-Suggeated wave form combinationsseem unnecessarily complicated. Since there seems to be a species difference for animals, why plan such a complete. series of wave form combinationa for studies involving only doga!

3.Concerning the budget for this propoaal, too many doge (1,l00) and unnecesaary surgery.are planned. No.continuous recording equipment for V.B.is listed--only indicatinginstrumente.

4. . If I recall correctly, the statement was made that Dr. in 2 years will obtain a PhD degree in physiology, Although Dr. is avell-qualified. D.V.M. and experienced in.electro-anesthesia .with animals, will there be a neuro physiologist consuitant in the proposed program of research? Also, anelectronics engineer should be available..The Project Proposal does not list the qualifications of Dr, or any of the technical assistants associated with the program.

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5.'. I hope my coments are not intarprated as opposing the awarding of a contract to Dr. )He-is highly motivated,interested and experiancad in the field of elactro-anesthesia and I hope that ho can modify his program to include,some of the suggestions listed above.

13 June 1966