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I feel sure you will be interested to learn that we were able to begla-our experiments with LSD-25 during the month of luly. We obtained S subjects who egreed to take the drug chronically. Alt of these were negro male patients and all of them physically were in very excellent shape. The time so far has been spent exclusively In obtaining control data which Includes physical andpsychiatrtc examinotions, Rorschach and Goldsteln-Scherer tests, Minnesota Multiphasis Personallty Inventories, electroencephalograms, steadlness test, blood chemistrles and hamatology. We should be in position to begin exploratory stodies designed to determlae the minimal effective dose for each man early in August.

Arrangemepts have been made with the Sandoz Compdny to obtaln a supply of the drug.

The behavlor of the patlents In our ward has been dtsappolntingly quiet. All five of the men heve been extremely quiet, agreeable and polite with each other, the psychiatrlc aldes and the doctors. They deflnitely are more-reserved than we expected and we have a dlstinct feeling that they are somewhat afrald, most especially of the physlcians Involved. We have made a strenuous effort to break through this barrier buthave succeeded only portially. The reletionshlp with the psychiatric aldes, who actually wili be the key observers, is bécoming somewhat more free and easy. but the degree of rapport attalned so far is not nearly so great as we expect with white subjects. Reserye and lack of rapport with the physicians are as greaf as iaitially- In all probability. this type of behavior is to be expected with patients of thls type. Perhaps the drug wlll break down some of the barriers.

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IN YI, AD 1n MOCAQERHAAGE POTLIC HEALTH SERVICE HOSPITA

FEDERAL.SECURITY AGENCY PUBLIC HEALTH SERVICE LEXINGTON, KENTUCKY 3 August 1953

NIMH Addictlon Research Center

Declassified. by —187475 dale 4 FEB 1977

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I have also heard that the "Alcometer" has been repaired end Is being shipped.. If no partlcular dlfficulties are experlenced in the LSD experiment, this will enable us to. begin prelimlaary work with aicohol some time during the fall.

Experiments wlth l-N-aliylaor Dromoran and the 3-methyl ether of Nallylnor Dromoran are not encouraging. Both compounds produce definite subjectIve effects when glven orally. The margin however appears to be qulte small. Total doses of 7.5 mg: oraliy seldom cause any pereeptible effects. Doses of l0 mg. orally almost lnvarlabiy do, but concomitantly, disturbing toxic effects, chiefly of vasovagal types Imarked, perspiration, dizziness on standing, weakness and drop In blood pressurel are observed, and these toxic effects definitely tnterfere with the elicitation of "depressed" material from the patlents.

Very sincerely yours,

There Shil

Harris Isbell, M.D. Director of Research

Hlira

Doslassified by —187475\_ date4FEB 1977