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I am enclosing three coples of a report "Studies on the Diethylamide of Lysergic Acid. lil. Effects of Phenoxybenzamine on LSD-Reaeticn In Mian." You will note that the pretreatment with phenoxybenzamine did not alter significantly the mental effects of I mcgm./kg..uf LSD. We thought you would be interested. in this information, and ycu may, of course, pass it on to any other persons who are working in the psychosominetic fleld.

Receatly i have been attempting to do the opposlte. Rather than attempting. to attenuate the LSD-reaction, l have attempted to accentuate it by administering epinephrine. So far, we have tried a combinaflon of l mcgm./kg. of LSD plus C.4 mg./70 kg. of epinephrine subcutaneously. There has been no evidence of any accentuation or blocking of the LSD-reaction as yet. The work ls continuing and the dose of epinephrine will gradually be raised.

Wé are also inittating preliminary studies on d-lysergic acid morpholide, d-lysergic acid pyrrolidid, d-dtmethylamide of lysergic acid, and 4-dihydro-lysergylamido-d-oxazolidone. All of these materials have been. furnlshed to us by the Sandoz Company. The object af the experiments wtll be to obtain information on the relation of chemical changes In the LSD molecule to changes in psychosorimefic ectivity. The first experiments will be designed to get a rough approximatien cf the sffective dose range in man, efter which critical experiments comperlng these two dose levels of each drug with two dose levels of LSD in the same subjects will be carried out.

With kindest personal regards,

Yours very sincerely,

HeriSbtecd Harris Isbell, M.O. Director VIECIUI

Enclosures psi Ns eyow hpue Buthes oo 4-392

IN RELYING △GORCSS THE NAAL INSUT O TAL HEAL ADICNON ASRAECH CENTER U.\$. O HALTH SEVICE HOSTAL . . 8 20

pP of HEALTH, EDUCATION, AND LFA.P : Health Service NATIONAL INSTITUTES OF HEALTH 2 Gctober 1957