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SUGGESTED LETTER TO

Roforonco is narlo to our recent convorsations concerning mnttora of specinl intorost to yourself and this agency.

I am trananitting herewith two (2) nemorandums which are solf-: explamtory.

It would bo appreointed if you would forvard these momorandums to the spooial projcet for thetr consideration and action,

Will you kindly arrango that any material or information made avuilable by the special projeot be forwarded to me at my offioe at your cerlioat possible convenience.

As provloualy discuosed, the intorest of this agency in thesp mattors should not bo discloaed.

Very truly yours,

1.18,1,543

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flutic  Hav: can sodium : or l' or ny other sloop inducing sgont bo boat conccaled in a normal or comon plaoe itom?

Promise - Thirst cnn bo inducod by keoping Suhjoct from water or civing thor snlty foods. 1

Coffec, brnudy, liqsor, ton are cornon roqucsts if a peraon is chilled or cold.

Fiurettus, cierrs aru atrost umivorsally used.

Itors suggosted for tests usiu: ry knoan sloop induaiig agents. Iho offeot should bo about thet of 6cc of sodium rytol on averge acult tnkon orelly. In conorol, tho moro rapid the Shduction of sloep tho bottor for operational nurposcs but a delayed nction (if timo could bo stondnrdizod) might alao be of valuo.

1 In connoction with tho above n parallol stuly should be made of mothods Lochniques. (depes. cionicals. etc.) thnt could be used to combat "nd countcract !hese sleop inducing, agonta.

A. In advnnce

B. ht tho smao tin9

C. Covor lon poriods of time (possibly by buitding up intornal resistancc).

A/B,1,5414

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Desoxyn - A proprietary brand of d-desoxysephedrine hydrochloride.

Desoxyephedrine - This drug is emploved in the forn of d-desoxyenhedrine hydrochloride to decrease the sense of fatigue, counteract sieepiness, and produce elevation of mood.

This drug was employed-in'the second test on the second case in the Artichoke operation in in June 1952. The drug was administered by h working with , and was injected into the Gilson apparatus by inserting a needle into the rubber tube ton which was in turn inserted by a needle into a vein in the arm of the subject. The drug was used after heavy dosages of sodium pentothal had placed the subject in a drowsy, "twilight, condition" and after a number of minutes of interrogation under this condition had been carried out. sugzested the use of the drug at this time to produce a more uninhibited state ano to make the subject, more talkative and more relaxed. The drug (in combination with sodium pentothal)as noted ahove had a dramatic effect in that it made the subject v:ry talkative, oxpansive, and produced a very romárkarle regressicn which carried the subject bick over aperiod of.15 vears and made the subject believe that the interpretor WaS an old and trusted associate.

The sodium pentothal coupled with the Desoxyn worked for a period of two hours with excellent results and although heavy dosages of sodium pentothal wers used initially, very small amounts only of the Dexoxyn were used.

1 In connection with the ahove, exact anounts of pentothal, Desoxyn etc. are.to be ound in the medical reports to be submitted hy

On the basis of the results in this case, it. is felt that Desoxyn andother drugs whiich are closely related to this coupound should he considered for future exploration hoth in research and actual case work in thefuture.

DF SOXVN