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Subject: 1l Report to ONR 21 Project Descrlption and Budget for Fiscal Year 1956 3) Recent Progress

(b)(3)

Enclosed herzwlth is copy of the annual progress report for the Office of Naval Research, which is being sent to Capt. F. H. Quimby, ONR, as was done in the past two years.

Also enclosed is a project descriptlon and budget for the fiscal year 195ó. in forwarding this l am assuming rhat arrongements for continuation of the project will be made and that the same procedure wlll be followed as was carried cut last year.

I am also enclosing two copies of an abstract which Is submitted for clzarance prlor to submisslon to the Secretery, Society for Pharmacology and Experimental Therapeutles. If the abstract is cleared and the information reclassifled, I latend to present this paper at the meetlag of the Soclety for Pharmacology and Experimentel Therapeuties In San Francisco, April 10-16, 1955.

Since my return from Europe I have completed some work which may be of lnterest to you. The experiments with Bufotenine were pushed untll the subjects were receiving oraliy total doses of 2 mg. of this compound. No discernable effects were obtalaed. Since work with this compound dld not seem at all promistng, we discoatinued work with lt, at least temporarlly. l think we shauld attempt to obtain another sample of the material in order to be sure we are doing work with the corrent compound.

We have just completed another series with patlents who recelved 75 mg. Chlorpromazlne followed by 60 mcgm. LSD-25. Thls makes a total of l8 patlents who have been studied with this partlcular combination. Definite blocking of LSD-effects did Apz occur, but

IN REPLYING. ADDRESS THE

DEPARTMENT OF HEALTH, EDUCATION. AND V. \_FAR FEDERALSECURHTY-AGENCY PUBLIC HEALTH SERVICE Lexington, Kentucky 8 December 1954

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NIMH Addlction Research Center

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not as great as In the pllot experiments. We have now turned to testing the ability of chlorpromazlne to reverse LSD-effects once they are well developed. As yet sufflclent data are not avallable to make any statement.

I must be in New York the nlght of February 3rd In order to give a lecture at the New York Academy of Medicine. It will be convenlent to stop in Washington on either February Ist or 2nd, provided you wish me to do so.

With kindest personal regards.

Very sincerely yours,

二 Harris Isbell, M.D.Director of Research

HI:rn Enclosures: 2