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1For ths past fosr years the Certal intelligence Agency bas boe zctivaly engigsd in researez ona grosp oi poveriul chemicala affscing tas bnmaarind called paychocharicala, Wa bave devaioped extansive
profzssional conticts, eqerisuce anà a considrrabis amount oí informa
foa ou many gsychocbemicals inclnding inparicular a matarial knos
as IS0. Tris Agcy is contirring its interest in this fisla, and is tha.
Jighr of its accualatza eperiezce ofers its co-operaton and assistanca
to rtsearca and deyelopment program which the Depastmeat oi Deisnse
ia considering at tis time. 2. Tae Agency becace izterested in tha potential importancs of?
psyccocremicals, primarily becanse of the enthusiasm and foresigit of
Dr. L. Wilson Greone, Teckical Dirsetor of the Chemical and Radiological
Laboretories at the Army Chemical Cester.Dr. Grcena's ideas were
imcloded ix 2 report writen by bimiz l9e9 eatitled "Paychochemical Wa
fare, a New Concept oi War. . 3. Since l93l fhis Agency bas carried out a program of reseirch
whicn as provided importart information on tha natre of the abnormal
benavior prośaced by L5D and the way tis etfecr varies witb such iactors
as sizo of dose, diffrrsaces in the indvidaal ord eavirorment The
behatioral effacto of repeaked doses sivenover a long tims haa bcen
stadialWe avs establizhed that indivicmla may develoy a tolerazce to
LSD, A sczrch for posaible antidotes is being mde. I has bepn found
tharLsD prcduczs rpmrkable mezial effects when taken in exceedingly
srall doses.The foregoingbecame increasingly interesding when it was.
recsnty discovered that LSD coulá be syatesized in quzasty. .4. There ars maay characteristics of LSD and oter psvchochamincia

8 5EC 1955

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cciazsive measses. Mipre  oaouid be accucnlated i it is desired to predict ts precise eect spoa a given individi uder siven bbace It wonid apper t be imporaat Sa Eeid rinls be mide to detemine the recti an gronpy of ppiz or on individuala cngazed ia groap activites, 5.This Azesy' sesas  bvs be respoble for tia esearc inpayctocieical bavs maistained closa and cffacHve liaison pitsvariousresearci ar áelorrt grups in e Departnt of Deienr ho ars aaact of our inttrestnd, in tarying degrees, of o progezs in ycrochendcis, Some of tbese indivduis ae DriWnsis Greee, Teckical Dircctor, Chemical Corps Cheical and Riiolosical Labaratories, Ary Chuical Canter Brnc Diil Sciesse Director, Cherical Corps, Medcal Laboratry.Ay Cherical Ceter Dr Acendeo Mirazi, a scitstst at the Madical Laboratory, Ary Chiical.Ceter Gaot,Cliffora P.pinebns,Chi,Biological Sciences Division Giicz oi Naval Research Brig.GeDoaD.Flicnge, ARDC, U.S,A,E. Lt, Col, Aleanier Batliz, Osce ofthe Assiotn Secretary ofDefesa (Researeh and Devtlopment) 6 In aadition, this Agcy ha prorided fsancial support for dertia pzojects in the field of psyehochemicala, being conducted by tho Chenlcal Corpr and dy the Oftce of Naval Research, We have noted wilh considerable interest tae cnrrrnt Departsest of Defense study oi the potential inportance of cartzin paychechemiral materials inciading LsD which ia being carzed ort by the-Aá Eoe Stay Group os Psycochomicals unier the Tecbnical Advisory Pancl o Gy and BW of te Ofcs oi the Aseirtnt Secretaryof Deitnse for Rzsearch and Dertloprent Konraccnmrlated iniormation, experieacr ard proiesaioral coriacts canbz oi any assistance, this Agonçy gladly offers its co-operaon iathis program ALLENWDULLES Copyoi 7 copies 5:5\~176

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Listibuton: Copy # 1 - Sec. of Defezse. Copy # 2 - Sec. of Defense
GSy3-DCI
Copy54-DCI
Copy F5-RI
Cepy  60/0c
Cepy7/CD