[PAGE 1]
01

2

18

[PAGE 2]
LD50 320.0 GREAT MED30 56.0 -18.0-180.0- RATIO LDSO/MED50 UNK

[PAGE 6]
S

[PAGE 7]
LD50100.0-79.0-120-0- MED500.32-0.10-1.0- RAT1O LD50/MED30 310.0

6

[PAGE 8]
7

[PAGE 10]
LD50130.00100.0-150.0- MED500.56 -0.13-1.3- RATIO LD50/MED50 220.0

[PAGE 11]
PAGE CS :

10

[PAGE 12]
一

[PAGE 13]
PAGE CS

[PAGE 14]
LD5063.0-50.0-79.0- MED500.32=0.10-1.0- RATTO LD50/MED50 200.0

13

[PAGE 16]
15

[PAGE 18]
17

[PAGE 20]
LD50 180.0 -56.0-560.0- MED50 10.0 -3.2-32.0- RATIC LD50/MED50 18.0

SAMPLE #2

19

[PAGE 21]
20

[PAGE 22]
L050160.0-56.C-360.0-ME0500.013-5.6-3-0.056-RATIO LD50/MED50 1.C+3

21

SAMPLE

[PAGE 23]
PAGE C5 SAMFL

[PAGE 24]
23

[PAGE 26]
LD5016.0-13.0-20c0-MED500.18 -0.056-0.56-RAT1C LD50/MED50 088.0

25

[PAGE 28]
27

[PAGE 29]
PAGE

[PAGE 31]
PAGE CS : SAMPL

[PAGE 32]
C

[PAGE 33]
32

[PAGE 34]
PAGE cS SAMP.

33

[PAGE 35]
LD50180.0 -55.0-550.0- MED50 56.0-1B.0-180.0- RAT1O LD50/MED50 3a2

PAGE CS SAM-

21

[PAGE 36]
LD50180.0-56.0-560.0ME5500.56-0.18-1.8-RAT10 LD50/MED50 320.0

CS

[PAGE 37]
FAGE CS

30

[PAGE 38]
LD50 36.0-26.0-49.0- MED500.56-0.18-1.8- RATIO LD50/MED50 63.0

[PAGE 39]
PAGE CS

3

[PAGE 40]
LD5011.0-8.9-14.0- MED50 0.56 -0.18-1.8- RATIO LD50/MED50 20.0

STATE SOLID

[PAGE 42]
LD50180.0-140.0-220.0- MED500.56-0.18-1.8- RATTO LD50/MED50 320.0

[PAGE 44]
LD5056.0-18。C-180.0- MED5C0.18-0,056-0,56- RAT10 LD50/MED50 310.0

[PAGE 46]
LD50 5.6-108-18.0- MED50 0c1-3-3.2-3-3.2-3= RAT1O LD50/MED50 5,600

[PAGE 47]
INTRAVENOUS TOXICITY TO MICE

46

[PAGE 50]
PAGE S:

[PAGE 51]
LD50180,0=56。0-560.0- MED5000018=5.6=3-00056= RATIO LD50/MED50 10,000.

50

[PAGE 52]
PAGE 93-

51

[PAGE 53]
LD50180.0-56.0=560.0- MED503.2 =1。0-10.0- RAT10 LD50/MED5056.0

521

[PAGE 54]
PAGE

53

[PAGE 56]
55

[PAGE 57]
56

[PAGE 58]
57

[PAGE 59]
L050 56。0 10.0-320.0- MED50 .10.0 =3.2-3200- RATIO LD50/MED50 5.6

[PAGE 61]
LD50 56.0 -18.0-180.0- MED50 1.8 =0.55-5.6- RATIO LD50/MED50 31.0

[PAGE 63]
PAGE A-62 334687

[PAGE 64]
LD5056.0-18.0-180.0- MED500.10-0,032-0.32- RAT10 LD50/MED50 560.0

[PAGE 65]
INTRAVENOUS TOXICITY TO MICE

PAGE. 342

[PAGE 67]
LD50 100.0 -32.0-320.0- MED50 18.0 -5.6-5600- LD50/MED50 600

60

[PAGE 68]
LD50 180.0 =56.0-560.0-

MED50 10.0 -3.2-32.0-

RAT10 LD50/MED50 180

[PAGE 72]
MIN. DEG- MIN. APPR REE RECOV

[PAGE 73]
12

[PAGE 74]
一

PAGE A-73 EXTRACT \_LC

[PAGE 75]
EXTRACT 120000

[PAGE 76]
75

EXTRACT 130000

[PAGE 77]
PAGE A-1b EXTRACT 140000

1

[PAGE 78]
EXTRACT 15OOCO .

77

[PAGE 79]
78

[PAGE 80]
PAGE A-79 EXTRACT 2

[PAGE 81]
80

EXTRACTL4LCO SAMPLE

[PAGE 84]
STATE LIQUID

83

EXTRA27 ELSC0

2

[PAGE 87]
PAGE A-86 EXTRACT Z\_

[PAGE 91]
90

[PAGE 92]
PAGE A-9

91

[PAGE 93]
921

[PAGE 117]
一

[PAGE 120]
611

[PAGE 128]
一

[PAGE 133]
63

[PAGE 154]
一

[PAGE 158]
Lsi

一

[PAGE 163]
二

[PAGE 165]
9

[PAGE 167]
991

[PAGE 170]
291

[PAGE 172]
CL

[PAGE 174]
2

[PAGE 177]
一

[PAGE 181]
131

[PAGE 185]
39

[PAGE 194]
197

[PAGE 197]
200

[PAGE 201]
PAGE A-20+

[PAGE 202]
一

[PAGE 205]
一

[PAGE 213]
一

[PAGE 214]
國

[PAGE 216]
FAGE A-ZLU

[PAGE 219]
282

[PAGE 223]
226

[PAGE 225]
PAGL A-LLY

[PAGE 230]
233

[PAGE 234]
231

[PAGE 236]
239

[PAGE 240]
243

[PAGE 263]
PHYORL L RAL NO A ARY K PERG G ING RESK VK  TAK SONNDS    NDS AO  EOUY UPG 09 RESS PS PMOUTE HEAE  BUE BUTE

PAGE A-∠O1

[PAGE 264]
SOL ELTER

PH ALAE O  OPUY UUPS KRE4E P POS HEAU E UE RUTE

DH AAD O  OUY UG RE RESTE PR POG HEE E UE UTE

PAGE A-∠08

[PAGE 265]
ROUY  U UUB RESS PS PUTE HEU  U BUTE

HEN  UTT RNUTE 96 RESSS OTE

HEE UE E UTE 2 KRESNS PS PMOUTE BODE  AURY AURT OS CN  CST

PAGE A-209

[PAGE 266]
SUUSSOS

PHYAL AL AVI NONSD DY R RY RND NG P PHIIA PUE Y RTE

BARYCUY TU.T RES MTS P PMO2 HE E U UTE

HEUU  U BUTE REOS M MMSOTE 78 U O PUE Y ETE

OBSAONS

PH O OO  COAS OTS

[PAGE 267]
NEUAL L NMAL AEHOML  O CG   GMAL NO CS L IS

HES S U UTE 72 RES PS PUTE BODR  OU UD

PUPE RLEY RLLETE RO  UY U° REG E R PPR1O HEANE LE UTE RUTE

PHT C CC C CTS CCTS

PAGE A-271

[PAGE 269]
SUR SOR SO  SO SOIN PHY  SN L  L AL NO A WS MST

PHT CGG CO OL GODL COTS

PAGE A-213

[PAGE 270]
SO   OER

PHCA AOR   U RERREOS PO POITE HE BE UE BUTE

PHACA AE COE  S CST POE  OU UUCE 06 RES  OTE HEAN U E BUTE

OSONS

(A-1) 日R

39

PAGE A-274

[PAGE 271]
%U° US  OS

P   AA OUR  OUUS R RE PS POTGE HE 1 E UTE

AO  U UG ESE PS MU HEAU B UE BUTE

PHY  A BO  OR UU°S RSESR RES PR PPT HEAU  G UTE

PRE DREE DPREOCOYL NESAL A NAL RREHHD N CE AL

HEA EE E UTE 30 KHES MNS MOTE OE   UU

PHS CO CO N AS CTS

[PAGE 272]
AE AAU B BUE BTE

PE E P POTA ENE B BU UTE

G  UTG UTE

CX  O  A

PAGE A-276

[PAGE 273]
MEING DEON XCS SON 06 G P PO

MEMMNG XS ON ENUUSTS

O  AYDENE EALCACECE CALM

60 HE P  OTE

TE HOURS 1M KG D0E MG/KG CATT NO PO SE

[PAGE 274]
OTH   TMAL LY  N N  AND GREG  H LEL HO   I R IOT EXE RMD  R RSMBS DENN  LE PENS LNN  PO

PHD  CO L OA CCT

[PAGE 275]
NEOMAL  MAL NEU  AMAL CALM

STED NO DY  RY BOE BOU TU°S 54 RESE MMR MOTE REA   OTE

NEOL  AL H  NO AU NOSD DDY C CCRY EAS RED

HE E E UTE 7a RES MMSS MUTE OE  U U SCLOA-VCION

OSONS

(A-1) 92L2

KHOUURSR MG/KG SX TIIME D0E CAT NO

PAGE. A-279

[PAGE 276]
SOL O      ER  ER

PRE DSE DS-DAYO NEUAL ML MAL BEO L O GAL IA GR GMAL CALM

HEE BE UTE UTE 44 RES P PRUTE NOI C  GSS

PAGE A-280

[PAGE 277]
PAGE A-281

[PAGE 278]
PHYYNSCCA CAB NOSE MN E IS O  U U.Z 99 RESS PNS POUTE HEUUTE EE UE UTE

OE  UY U° RESUS POS PMUTE HE 1 UTEG UTE

HEAU E UE BUTE 2 KESSOE PS POUTE RO  U RC CALM

HOURS GX AND SEX T1E 3003 CAT NNO.

PAGE A-282

[PAGE 287]
KN L  ITED NESOLS CAL AL BAEEPPR AAR ANCE NOL ML  OST

VOE CY OERURY UPE BE RE P POTE HEA 1 UTE

KRN  J JEG PHYA SALR RENS  AENON AOISE AN  S PIAOHdO1OA

(A-1) 18

DUR C BUOU UUCO 76 RESS ON MSOITE HEANG E TE NUTE

[PAGE 298]
PAGE A-302

H S S AL

PHHCALL A NOD D C RY POLE  ORU U RE EN P PMOT4O HEA  BE BUTE

EASTS

AORE  AUY UUPZ RE PRESES PS PPOT3E HENG  RNUTEG BUTE

HEAN 11 E BUTE 24 RES PS PSOOITE AORE C OU AU

OUASONS

(A-1) 2019

[PAGE 303]
htr

%5°0 SUEESUOSE

[PAGE 308]
SUS°% USSNMUOSS

HE  U UTE 09 RESOS PNS MUTE AOE  OY UB

HEAUE  UE BUITE か5 PHAAL E PRNS POTE AO  UU TU°

AEAUG  U UTE 22 PPA RES  OTE

A RO  OPU UUR KESRE PE PPOT2 HEAU  BUTE BUTE

(A-1) ZEIIG

[PAGE 311]
HEA  U BUTE 9€ PH YAC CAE RES P POTE RO UY TUB

HEU E UTE UTE 04 PB H AB RESU UTE ROE C RY TURE

[PAGE 313]
PLABO  ORPUUY TURE4 RES P POTIS4HEAUUE BE BU BUTE

HEANS BE BT BUTE 54 P H AL RESU P PUTE ARE  UY U

A. OR  UY UOZ RFRE P OT4E HERT T BUTT BUTE

HEUE EE BTE BUTE 60 RESUS PN UTE O  S SS P AL AL

OSONS

[PAGE 315]
HEU  BU BUTE 2L P  AL RES PS PRPOTE HOUE  OU TUU°S

[PAGE 319]
PHAL AE AOE  OU TU G RES RES P PMO4O HEU B BUTE BUTE

PHALAE BO  U TUG KREERESE PE POT42 HEBU BU U BUTE

HEA  E AUTE 242 PH AL RES PNSPOTE POD UY U8.T

[PAGE 320]
PHAA AOE C U UPZ RE REE PO POT36 HEUUT UT UTE

PHALE AOE  OUU TUPZ ROER RE P POIEO HEUE UUTEG UTE

RHO  TU RERES S OOT3G HEE BBE BTE UTE

HOR  OA UB RE OE PNE POI3G HEUUE  U UTE

[PAGE 325]
OTHS   S LS  ME AR D D D DI PRO D N  SOND

4

[PAGE 330]
HEA B UE BUTE 28 PHYL AE RESOS MS POTE BO  UY TUB

HEA  BU BUTE 32 PH AE RESSPS POTE AOE  OU TUZ

HE  E BUITE 33 PHAE RESS PNS PROTE OU  U UOL

[PAGE 332]
JE

[PAGE 334]
PHCAL AE AOOUU TU4 RE6ENS PS PMO36 HE  UT UTE

PH AAE AO  PURY TUZ R RE PS PMOIG HEU  UE NUTE

[PAGE 335]
HEA  EG BUTE 32 PHL AA RES PS PMOTE AO Y UUUUPB

HEA ZS  UTE 24 PHYYY CAE RESS S MMSOTE AODR Y OU UOI

HEAS E UE BUTE 9E PH A RES RS PEOE AODY  OU U.

[PAGE 336]
05°0 SUSUSOS

PHHL SALL AL AL MAL R RESE S GO HEN  EUN BNUTE

PHALCAE 6 RES  MO66 HEAG BG  NUTEE

PYYCL CCAE O Y OUY U°2 RESS PUTE HEA  BE BUTE

PRAE DS DSDOAY) NEAL N NAL BEHRA GI GNCEL ACVV

[PAGE 337]
RES ES P MO4 HET BBU UTE BUTE

PH L A RES  PS P8 HEAU U UG BUTE

HEAT 1 UTE BUTE 87 PH YYLCAB RES  PUTE AO Y OPUUY U.0

國

[PAGE 339]
AND SEX CAT NO. ML/KG DOSE KG. WT. HOURS TIME

UBSERVATIONS

HEART RATE 144 BEATS/MINUTE RESPIRATIONS PER MINUTE 102 BODY TEMPERATURE C 37.3 NICTITATING MEMBRANE RELAXED +++ SCLERA - VASODILATION

EARS RED NOSE COOL AND MOIST LYING ON SIVE, WITH HEAD UP NEUROLOGICAL TESTS NORMAL

HEART RATE 12O BEATS/MINUTERESPIRATIONS PER MINUTE 96BODY TEMPERATURE C 37.4

NOSE COOL AND DRY BEHAVIOR AND APPEARANCE - OTHERWISE NORMAL NEUROLOGICAL TESTS NORMAL KNEE JERK NOT TESTED

NICTITATING MEMBRANE RELAXED + OTHER TESTS NOT DONE AT THIS TIME

NICTITATING MEMBRANE NORMAL

SOLUTION- DISTIILED WATER

PHYSICAL ÀND NEUROLOGICAL EXAMINATION OF CATS

[PAGE 340]
BODY TEMPERATURE C 38.S RESPIRATIONS PER MINUTE HEART RATE 168 BEATS/MINUTE72

CALM BEHAVIOR, GENERAL APPEARANCE, AND CONDITION - NORMAL NEUROLOGICAL TESTS NORMAL PRE-DOSE (SAME DAY)

BODY TEMPERATURE C 38.5 RESPIRATIONS PER MINUTE HEART RATE 16Z BEATS/MINUTE78

GROWLING WHEN HANDLED PHYSICAL, NEUROLOGICAL。 & BEHAVIORAL SIGNS UTHERWISE NORMAL

SOLUTION - DISTILLED WATER

PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS

國

[PAGE 341]
PHYSICAL, NEUROLOGICAL & BEHAVIORAL SIGNS NORMAL BODY TEMPERATURE C 38.6 RESPIRATIONS PERMINUTE 60 HEART RATE 162 BEATS/MINUTE

GROWLING WHEN HANDLED PHYSICAL· NEUROLOGICAL, & BEHAVIORAL SIGNS OTHERWISE NORMAL

GROWLING WHEN HANDLED PHYSICAL, NEUROLOGICAL, & BEHAVIORAL SIGNS OTHERWISE NORMAL

PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS

BODY TEMPERATUREC 39.5 RESPIRATIONS PER MINUTE 78 HEART RATE 132 BEATS/MINUTE

HODY TEMPÉRATURE C 4O.O RESPIRATIONS PER MINUTE 66 HEART RATE 162 BEATS/MINUTE

SOLUTION - DISTILLED WATER

[PAGE 342]
HEART RATE 168 BEATS/MINUTE RESPIRATIONS PER MINUTE 72. BODY TEMPÉRATURE C 39.9

GROWLING WHEN HANOLED BEHAVIOR AND ARPEARANCE - OTHERWISE NORMAL NEUROLOGICAL EXAMINATION NOT DONE

UODY TEMPERA1URE C 39.2 RESPIRATIONS PER MINUTE HEART RATE 156 BEATS/MINUTE78

CALM BEHAVIOR AND APPEARANCE - OTHERWISE NORMAL NEUROLOGICAL EXAMINATION NOT DONE

SOLUTION - DISTILLED WATER

PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS

[PAGE 343]
HODY TEMPERATURE C 37.8 RESPIRATIONS PER MINUTE HEART RATE 156 BEATS/MINUTE84

ACTIVE + BEHAVIOR GENERAL APPEARANCE AND CONDITION - NORMAL NEUROLOGICAL TESTS NORMAL PRE-DOSE (SAMEDAY)

HEART RATE 168 BEATS/MINUTE RESPIRATIONS PER MINUTE 102 BODY TEMFERATURE C 38。2

NASAL CONGESTION + PHYSICAL, NEUROLOGICAL, & BEHAVIORAL SIGNS OTHERWISE NORMAL

HEART RATE 144 BEATS/MINUTERESPIRAIIONS PER MINUTE 78BODY TEMPERAIURE C 38.4 BUUT TEMPEKATURE L JOT

BEHAVIOR, GENERAL APPEARANCE AND CONDITION - NORMAL NEUROLOGICAL TESTS NORMAL

SOLUTION - DISTILLED WATER

PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS

[PAGE 344]
HEART RATE 16Z BEATS/MINUTERESPIRATIONS PER MINUTE 102HODY TEMPERATURE C 38.6

NASAL CONGES1ION \* PHYSICAL: NEUROLOGICAL & BEHAVIURAL SIGNS OTHERWISE NORMAL

HEART RATE 162 BEATS/MINUTE RESPIRATIONS PER MINUTE 8O BODY TEMPERATURE C 38.O

NASAL CONGESTION + PHYSICAL, NEUROLOGICAL, & BEHAVIORAL SIGNS OTHERWISE NORMAL

SOLUTION - DISTILLED WATER

[PAGE 386]
PAGE A-390

[PAGE 387]
PAGE A-391

[PAGE 390]
PAGE A-334

[PAGE 395]
ON SOUIRREL MONKEYS

Compound Number-2438B: (soln. HO I.V.)

PHYSICAL. NEUROLOGICAL, AND BEHAVIORA. EXAMINATIONS

[PAGE 396]
ON SQUIRREL MONKEYS

Compound Number-2438B: (soln. H0 I.V.) continued

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

PAGE A-

[PAGE 397]
ON SQUIRREL MCNKEYS

Compound Number-2438B: (soln. H,0 I.V.) coutinued

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

PAGE A-400

[PAGE 398]
PHYSICAL,NEUROLOGICAL, AND REHAVIORAT, EXAMINATIONS

ON SQUIRREL MONKEYS

Compound Number--2438B: (soln. HO I.V.)

[PAGE 399]
PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

ON SQUIRREL MONKEYS

Compound Number--2438B: (soln. H,0 I.V.) continuer

Monkey Dose Weight Time Elfects Sex & No mg/kg9 hrs.

0.90 Normal response to all F5 5 stimuli cues. Female (15) cumulative

1.00 Normal response. to all stimuli cues.

1.30 Normal response to all stimuli cues.

24.00 Home cage: ncrmal-response to all stimuli cues.

PAGE A-L

[PAGE 400]
ON SQUIRREL MONKEYS

Compound Number-2438B: (soln. H20 I.V.)

PAGE A-

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 401]
ON SQUIRREL MONKEYS

Compound Number-22438B: (soln. H.0 I,V.) continued

PHYSICAL,NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 402]
ON SOUIRREL MONKEYS

Compound Number-2615: (soln. 0.5% Mr hylceitulose-I..)

2

PAGE A-

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATTONG

[PAGE 403]
PHYSICAL, NEUROLCGICAL, AND BEHAVIORAL EXAMINATIONS

ON SQUIRREL MONKEYS

ComoJund Numbez-2776: (soin. 100% PEG 300 I.V.)

PAGE A-4

[PAGE 404]
ON SQUIRREL MONKEYS

Compound Number--2808: (soln. 1/10N HCL I.V.)

PAGE A-4C

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 405]
PHYSICAL, NEUROLCGICAL, AND BEHAVIORAL EXAMINATIONS

ON SQUIRPEL MONKEYS

Compcund Numbez-2808: (soln. 1/iON HCL I.V.)ccntina

Monke No. mo/kg elot Dose Welght Time hrs. Effects

F6 16.16 3.40 Normai reactions to all stimuli cues. Female (28.28)cumulative

3.60 Same as apove; normal.

4.00 Home cage: normal reactions to all stizuli cues.

24.00 Kome cace: normal reacticns: to all stiuli.cues.

PÁGE A

[PAGE 406]
PAGE A-4

2850: (soln. H₂O I.V.)

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

ON SQUIRREL MONKEYS

[PAGE 407]
. Compound Number-2850: (soln. H0 1.V.)

PAGE A-:

PHYSICAL.NEUROLGGICAL, AND BEHAVIORAL. EXAMINATIONS

ON SQUIRREL MONKEYS

[PAGE 408]
ON SQUIRREL MONKEYS

Compound Number--2850: (soln. H,0 I.V.) continued

PAGE A-L

PHYSICAL,NEUROLOGICAL,AND BEHAVIORAL EXAMINATIONS

[PAGE 409]
PHYSICAL, NEUROLOGICAL,AND BEHAVIORAL EXAMINATIONS

ON SQUIRREL MONKEYS

Compound Number--2850: (soln. H.0 I.V.)

PAGE A-4

[PAGE 410]
ON SQUIRREL MONKEYS

Compound Number--2851: (soln. 1/10N HCL I.V.)

PAGE A-L

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 411]
ON SQUIRREL MONKEYS

Compound Number--2851: (soln. 1/10N HCL 1.V.)continusd

Monkey Dose Weight Time Sex & No. ma/ka 9 hrs. Effects

F2 26.88 2.7C Crouch; quiet; alert. Female (53.76)cumulative2.30 Normal reactions. to all stiaull cues.

3.00Same as above; normal.

3.50Same as above; normal.

24.00 Home cage: normal reacticns to ali stimuli cues.

PAGE A-4

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 412]
PHYSICAL, NEUROLOGICAL,AND BEHAVIORAL EXAMINATIONS

ON SQUIRREL MONKEYS

Ccmcound Number--2867: (soln. H,0. SQ)

PAGE A-L

[PAGE 413]
PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

ON SQUIRREL MONKEYS

(rkound Numberz2867: (soln, H0 SQ) continned

Korney Dose Weight Time Sez C No mg/kgg hrs.

B 8.00 3.10 Kale (14.00) cumulative

Normal reactions to all stimuli cues.

3.20Pupils seem constricted.

3.50 Shuttled to light cue (response tc light cue delayed); movement s.ightly slow and awkward.

3.70 Pulse: 300/minute Respirations:72/minute Pupils: constricted Did not shuttle to light cue or to high electric shock; sat bentover as ir in distress.

4.30 Head hung low, face on floor.

4.50 Mcvements sluggish; shuttled to light cue and to eisctric shock, but only if doors closed, then opened aiter cue or shock; shuttled spontaneously a little.

4.70 Salivation.

21.70 Appearanor and bohavior nornal; siuttled spontaneously at nortal rate; pupii size and reflex normal.

[PAGE 414]
ON SQUIRREL MONKEYS

Conpound Number-288l: (soln. 0.5% Methylceliuiose I.V. and I.P.)

PAGE A-4

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 415]
PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

ON SQUIRREL MONKEYS

Compound Number--5034: (soln. H2O-I.V.)

PAGE A-L

[PAGE 416]
PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

ON SQUIRREL MONKEYS

Compound Number-5034:(soln. $\mathbb { E } _ { 2 } \circ - \ I \circ \mathbb { V } = 1$ continued

Monkey DoseWeight Time Sex & No. mg/kgg. hrs. Effects

F2 2.13 2.00 Normal reactions to all stimuli c Female (4.26)cumulative 2.10 Eats apple; normal.

2.30 Normal reactions to all stimuli. c

2.70 Normal reactions to all stimuli c

3.10 Normal reactions to all stimuli c

PAGE A-

[PAGE 417]
ON SQUIRREL MONKEYS

Compound Number--5034:(soln.0.5% Methylcellulose I.V.)

PAGE A-

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 418]
ON SQUIRREL MONKEYS

Compound Number- 5036: (soln. H20 I.V.)

PAGE A-L

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 419]
ON SQUIRREL MONKEYS

Compound Number-5049: (soln. 0.5% Methylcellulose I.V.)

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 420]
ON SQUIRREL MONKEYS

Compound Number-5049: (soln. 0.5% Methylcellulose I.V.) continued

Monkey Dose Weight Time Sex & No mg/kgg.hrs.

F4 19.00 2.80 Pupillary response normal; Female (30.90)cumulative general behavior unchanged,

Effects

3.0 Eats apple; normal reactions to all stimuli cues.

3.40 Normal reactions to all stimuli cues.

4.00 Same as above; normal.

24.00 Home cage: normal reactions to all stimuli cues.

PAGE

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 421]
ON SQUIRREL MONKEYS

Compound Number- 5058: (soln. H20 SQ )

PAGE A-

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 422]
PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

ON SQUIRREL MONKEYS

Compound Number-5058: (soln. H0 SQ) continued

Dose Weight Time mg/kg g. hrs.

4.50 1.80 (7.70) cumulative

Effects

Normal reactións to all stimuli cues.

1.90 PuIse: 264/minute Respirations:78/minute Pupil size and reflex normal.

1.80-Continual contact huddling:
2.30 minimal locomotory activity; awake; alert; appearance and behavior normal generally.

2.30- Increasing locomotory activity-

2.80 Shuttling spontaneously eight times/minute.

3 2

[PAGE 423]
Compound Number--5113:(soln.0.5% Methylcellulose I.V.)

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

PAGE

ON SQUIRREL MONKEYS

[PAGE 424]
ON SQUIRREL MONKEYS

Comoound Numher-5113: (soln. 0.5% Methylcellulose I.V.) continued

Monkey Dose Weight Time Sex & No. mg/kgg. hrs.

F3 32.00 2.10 Female (48.00)cumulative

Effects Normal reactions to all stimuli cues.

2.30Same as above; normal.

4.00 Normal reactionsto all stimuli cues.

24.00 Home cage: normal reactions to all stimuli cues..

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

PAGE

[PAGE 425]
ON SQUIRREL MONKEYS

Compound Number--5113: (soln. 0.5% Methylcellulose I.V.)

PAGE

國

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 426]
ON SQUIRREL MONKEYS

Compound Number-5129: (soln. H2O I.V.)

'PAGE

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 427]
ON SQUIRREL MONKEYS

Compound Number-5129: (soln. H,0 I.V.) continued

Monkey Dose Weight Time Sex & No. mg/kgg. hrs.

Female 5.80 1.40 Alertbtal closi crouch; (10.20) cumulative

7.40 1.60 Increased locomotory activities. (17.60)cumulative

1.70 Good grasp reflex; normal reactions to sound, light.

1.75 Normal escape reaction to investigatory still anorexic; crouch; head down; palpebral closure.

2.00 PalpebraI closure; quick to react to stimuli, however.

2.10 Very quick; nervous;'escape reaction to investigator.

2.20 Palpebral closures; alert\_to sound

2.30 Normal reactions to all stimuli cues.

2.60 Same as above; normal.

3.00 Same as above; normal.

6.00 Home cage: normal.

24.00 Home cage:. normal reactions co all stimuli cues.

PHYSICAL,NEUROLOGICAL,ANDBEHAVIORALEXAMINATIONS

PAGE

[PAGE 428]
ON SQUIRREL MONKEYS

Compound Number-521l:(soln.0.5% Methylcellulose I.V.)

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

PAGE

[PAGE 429]
Compound Number--9346-29: (soln, H20 I.V.)

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

PAGE

ON SQUIRREL MONKEYS

[PAGE 430]
ON SQUIRREL MONKEYS

Compound Number--9346-29:(soln, $\mathtt { a } _ { 2 } \circ$ I.V.) continued

Monkey Dose Weight Time Sex & No.mg/kg9 hrs. Effects

0.61 Jerk--escape reaction to shock

0.80Escape reaction to shock.

1.50 Escape--jump reaction to shock

1.80 Alert; active; ignores apple.

2.00 Temperature--100.8°FPulse--212/minuteRespirations--76/minutePupil size--l.5mm

3.00 Normal reactions to all stimuli cues.

24.00Normal reactions to all stimuli cues.

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PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 431]
ON SQUIRREL MONKEYS

Compound Number--9346-37: (soln. H20 I.V.)

PAGE

PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS

[PAGE 435]
PAGE A