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Dr. Harris Igbell
Directcr of Research
U.S. Public Eealth Service Hospital
Addiction Reseerch Center
Box 2C00
Lexington, Kentucky

Dear Dr. Isbell:

Your letter of 28 Cetober 1958 was moat inforzative. end is greatly appreciated.

The observations on the sedative. effect of copound No. 231g4 as well as your comments on Dr, Janssen's compound are most interesting. Both meterials may well prove to be of considerable value pn our research endeavors.

The thermofax copy of Dr. Hoffman's presentaticn cn Psilocybin is greatfully received and provides us with much needed background information. I have read vith a great deal of interest your anmual prcgress report on the addiction liabilities of synthetic substitutea for codine. With reference to the previous mentioned coapound of Dr. Janssen I vould eppreciate beihg kept infcrmed shoulà the compouná or reports on its experimental use become available.

I em planning to visit you in Jamuary at a time acceptable to you. If you have.any suggestions as to dates acceptable to you please edvise re.

With kindest personal regards,