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I am enclosing copy of a report "Effect of Epinephrine on the LSD Reaction." You will notice that we were unable to either accentuate or inhibit the LSD reaction by injection of 0.4-0.6 mg. epinephrine /70 kg. subcutaneousiy. Taken in conjunction with our failure to block the mental effects of LSD with Dibenzyline, I feel that these data are a further indication that the adenergic hypothesis of the LSD reaction must be questioned rather strenuously.

Preliminary assessment of four materials received from the Sandoz Company has now been compieted. Three of the materials proved to be psychotomimetic agents, though weaker than LSD. The doses approximately equivalent to 1.0-1.5 mcg./kg. of LSD are: LSM, 6-9 mcg./kg.; DAM-57, 10-15 mcg./kg.; LPD-824, 10-15 mcg./kg. A more extensive study of these three materials is now underway.

DLO-57 did not Induce any psychotomimetic changes, even in doses of 100 mcg-/kg. A further direct investigation of this particular compound is therefore being dropped. Possibly, potential cross-tolerarce between it and LSD might be studied at some future date.

I am enclosing thermofax'copies of material concerning other LSD congeners which have been' forwarded to me by the Sandoz Conpany.

Please let us know if there is any way in which we can assist you with your program.

Yours very sincerely, darrbeel Harris Isbell, M.D. Director

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Depaof HEALTH, EDUCATION, AND LFAREPublic Health Sarvice NATIONAL INSTITUTES OF HEALTH

IN REPGYING ADOFIIS THE. NATIONAL )NSOT Os MENTAL HTALTH ADDI RESEARGH CNTA U.S, PUELICHEAST STRVICE HOSAL P. D. Bo 20de LSZINGTOH, KENTUCSY

10 December 1957

HI:lw Enclosures