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I am enclosing reports on d-dihydro-LSD, 1-Methyld-lysergic acid butanolamide, and elymociavine. The first two are materials received from the Sandoz Company. Neither seems of particularly great interest at the moment. D-dihydro-LSD is about one-third as potent as LSD, whereas 1-Methyl-d-lysergic acid butanolamide is not a psychotomimetic. Elymoclavine is of some interest since, like agroclavine, it induces sedative effects in man, and may in fact be more potent than agroclavine or Liliy 23194.

We plan to do a dose-effect curve with this latter material, provided an additional supply can be obtained, and to compare it directly with secobarbital.

Yours very sincerely,

HerriDfeel Harris Isbell, M.D. Director

Hi:rn

Enclosures

PUBLIC HEALTH SERVICE 13 May 1959

159.

DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE

Nedoaa lartitte of Mental Hesith Addiction Restarcs Cratw U.5, Pubüle Health Serrics Heepital Lesiegtos, Ictucky