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ATTEMPTS TO BLOCK THE LSO. REACTICN BY PRETREATMENT WITH BOL FOR TWO-DAYS

These experiments were carrled out because of the reports of Ginzel and Mayer-Gross that 2 day's pretreatment with BOL completely blocked the LSD reactlon and one-day's pretreatment with BOL attenuated it.

Because of shortage of BOL, only 8 subjects could be used. Slx of these subjects had not had LSD before. Insofar as was possIble, we attempted to reproduce the experiment of Ginzel and Mayer-Gross. The drug comblnatlons used were: BOL placebo and LSD placebo; BOL and LSD; and BOL placebo plus LSD. Combinatlon of BOL plus LSD placebo was not studied because of the shortage of materlal and because it was believed that the results would be essentlally simllar to those described under acute administration of BOL.

BOL was given orally. I mg. was given three times dally for two days prlor to administratlon of LSD, and an addltional l mg. was given two hours prlor to LSD. Dose of LSD varled between l-2 mcgm./kg. of bodyweight.

Measurements Included threshold for kneejerk, puplllary size, resting systolic blood pressure, responses

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BOL DAILY FUR 2 DAYS BEFORE LSD

1.O mg. of BOl was given three times deily for.2 days prior to LSD and an additional dose given 2 hours prior to LSD. Dosage of LSD varied from 1.0-2.0 mcg./kg. love. 1.4 mcg./kg1. Figures arz means ± standard errors on 8 subjects.

EFFECTS OF ADMINISTERING 3.O MG. OF