[PAGE 1]
Purpoge; To study the role of the human brain in overall adaptive behavior. Speoifically, to shoy the relationahip of changes in behavior due to stress (pental disorders, sensory.deprivation,.peptic ulcers, threatening life situations, etc.) to changes in behavior brought about by actual loss of cerebral tissue (MOULTRA 61).

Initiated: OF na1 reeearch program initiated in 1956 as part of gect, Current research initiated in August 196

Contractor: Dr.

as a grantee of the

Cost: 60,797.36. (This 1s the last year in which this sctivity will be funded by the Agency.)

Status:.

61-1

[PAGE 4]
Septeaber 20, 19€0

Centlemen:

We are pleased to be able to transait to you the following tundst

Treasurer'a Check No, 177038 draw on or \$58,459.00 dated September 16, 19

Treasurer's Check No. 255091 \$2,338.36, dated September 16, 1960.

These funds represent-a contribution-for the uee of your directors in carrying out the very worthwhile research goals of your organization.

Yours truly,

Encl. Checks (2)

[PAGE 5]
MOWORANDUN FOR: CHIEY, PINANCE DIVISION

1 T6D/Budget Officer

SURJSCT

MALTA, Subproject 61, Invoico f6 Allotment Nuabor 1525-1009-1902.

1. Invoice No. 6 covering the above subproject is attached. Payuent ahould be mede es follovst

Ceahier's cheok in the aount of \$58,459 payable to B drawn on

Cashier'a check in the aoount of €2,338.36 paya able té P drawn on .E

2. Please forvard the checks to Chief, TSD/Research Brench through TSD/Budget Officer, no lator then Thursday, 8 Soptaaber 1960.

3. This is a final invoice. Hovever, sinco it is enticipated that additicoal funds vill to obligated for this projeot, the files should not bo closed.

dier TSD/Research Division

Attacbed: Invoice & Certifications

Distribution: Orig & 2 - Addreecee

CERTIFY THAT FUNDS'ARE AVAILABLEI ONIGATION REFERCNCE N7 CHARGE 1O ALLOTE12S1009402

CHECK#25509
REDEIVI9

61-5

1 Septsaber 1960

[PAGE 6]
For services

INVOICE

\$60,797.36

CERTIPICATIONS

(1) It 1e hereby certiried that this is Invoico No. 6 applying to Subproject 61 of MALTRA, that perfornance 1a satisfectory, that services are boing accoaplished in accordance vith mautual agreements, that a detailed agenda of the paywonts and receipts is filed in TSD/RB, that this bill is juat and correct and that payment thereor has not yot been made.

Chief, AD/Besearch Branch

(2) It 1s bereby certiried that thia iavoice epplies to Subproject 61 under MLTRA which vas duly approved end the project 1e being carried out in accordance with the memorandum dated 13 April 1953 from the DCI to the DD/A, and the extension of this euthority in subaequent memoranda.

Rasearch Director

[PAGE 7]
Cost Account1125-108.1002

Object Class

[PAGE 8]
MEMORANDUH FORI COMPTROLIER

ATTENPION: Finance Division

SUBJECT 1 MKULRA, SubproJect 61

Uxler the authority granted in the mesoraniua dated 13 April 1953 froa the DCI to tho DD/A, and the extenaioa of thie cuthority in subsequent meaoranda, Subproject 61 has been : approved and ș60,797.36 of the over-all MULTA project funda hao been obligatei to cover the aubproject's expenses. Thie cbligation or funde should be chargod to A1lotment 1925-1009- 1902.

AFPROVED POR OBLIGATIOH OF FUNDS:

1 CERTIFY THAT FUNOS ARE AVAILABLE ORLIGATION REFERENCE No. CHALGE 10 ALLOTMENT NO. 112S-1009.1902

Divtribution: Oriá & 2 - Addressee

61-6

29 Auguat 1960

AUTHORIZING OFFICER

[PAGE 9]
For 12 Months: September 1, 1960 through August 31, 1961

[PAGE 10]
SUBJECT: Continuation of Project MKULTRA, Subproject 61

1. The purpose-of this Subproject is for support for one year of Dr tudies on the role or the human brain in overall adaptive behavior. It has been shown that changes in behavior due to yarious kinds of stress (senecry deprivation, threatening life situations, mental digorders, peptic ulcere, etc.) are comparable to those behavioral changes which are brought about by actual loss of cerebral tissue.In the couree of this research new techniques of measurement and new inatrumentation is being developed with applications in other areas of TSD/interests. G

2. It is anticipated that this will be the last year in wbich this research activity will.be funded by ua. Although several portions of the work have been and will continue to be supported from cther sources, it is felt that Dr. and his group can obtain total research support for continuing wcrk in this area from other Government and private sourcea after this next year.

cover and cutout for this project., The attached proposal indicates a cost of \$58.459 for one year. To this must be added \$2,338.36 which represents the 4% service charge due to the cutcut. The coet of the project for one year vi11 therefore not exceet \$60,797.36. Charges

61-7

cate: 3ane 1577

P2 JEF2ET: CL BY 18747S

DRAFT 29 August 1960

MEMORANDUM FOR THE RECORD

[PAGE 11]
to Submit to them a summary eccounting on an

annual basis of all monies received from the Society. Also, it has. been requested that any unexpended funds be returned as soon as possible upon the close of the grant year;

5. Title to any permanent equipment purchased by funds granted the Univeraity shall be retäined by the University in lieu of higher overhead rates.

6. In connection with travel under this project, it is agreed that the Agency will accept the\_travel documentation and accounting which conform with the practices of-the University.

APPROVED FOR OBLIGATION OF FUNDS:

Attached: Froposal and Budget

Distribution: Orig only.

617

neod to 75 C 2 137475

[PAGE 12]
The group wll continue to Investigate the role of the central nervous system

In human diseose.

1. One branch of these activities will be concerned with extending and analyzlng O phenomenon established In prevlous studles, that the functional copacity of the central nervous system Is Impalred following prolonged perlods of inadequate and unsuccessful adaptatlon. Two projects will be carried out. The first Is on extensive analysis and comprehensive formulaton of data already gathercd In whIch the highest Integratlve function of patients diagnosed as having chronlc and of : patlents with prolonged C

and s severa were ossessed. As the analysts proceeds edditlonal psychologtcal tests and observotions of such subjects wlll be required. The second Is concerned with. the observotion thot subjects with as well as ostensibly Intoct potlents with prolonged an ara defective In their copacity to for "temporary cerebral connectlons" or "conditloned reoctlons" as demonstrated by the eloctroencephalograph, Those observotions will be extended to Include hospitalized patlents with schizophrenic reactiors, patients with leslons of the brain in reglons other than the cerebral hemispheres, and subjects who are experlencing severe stress and/ or anxiety, especlally In subjects who are adapiing to a new envlronment.

2. Studies designed to examine the hypothesis that the medlator substonce of axon reflex vosodllatotion (neurokinin) Is Impllcated In the mechanlsm of o voricty of dlseoso states.

under the directlon of

Proposed ActivIties from September 1, 1960 through August 3), 1961 of the

[PAGE 13]
a) It has been established that neurokInIn Is present In Increosed amounts In the painful and tender reglons of the scalp during vascular headache of the mlgralne type. Further characterization of the pharmacodynamic and blochemlcal features of thls subcutaneous perfusate will be carrled out. Also, a laboratory mothod will be sought for screening of agents posslbly useful In treatment of migralne headoche. Thls method would be bosed on the pręperties of agents thot antogonize neurokinln or the neurokinin forming enzymo.

b) Attempts will be mode to measure the neurokinin content of perfusates ond "woshes" of abdominal viscera before and during Intervlews dealing with ospects of the patients' Iife situation that ore portlculorly threatenIng. . Patlents with colostomles or ileostomies with and withouf ulceratlve colltls will be one group studled. Subcutoneous perfusate of urticarlous reglons of skin will also be studled.

3 Biochemical and phormacologlcal studles of neurokinin will continue. a) Methods ore now belng developed to prepore lorge quantIties of neurokinin. b) In cooperatlon wIth the Deportment of parffication and chemlcal
chargcterizatlon of neurokInln wlll be attempted.

c) Pharmacological studles of the properties of neurokinin will be continued. Prelimlnory studles have Indlcated that neurokinin Is antagonized In vitro by the sterold hormones of the adrenal cortex ond by salicylote. This observation may be pertinent to the anti-inflammatory action of these agents. Studies of the actlon of these agents on the enzymo that forms neurokinin will be undertaken. Also it hos been observed that LSD-25, an agent that Induces delirium when administered In extremely small amounts, strongly potentlates one apporent action of neurokInin (stimulation of resplration). Related sutstances

61-7

[PAGE 14]
BOl, UML, do thls to a lesser degree. There obsetvatlons are particularly Interesting In view of our observation of the abnormally high levels of neurokintn-forming enzyme In cerebrospinal fluid collected from potlents wi Also, prelimInory observotions of ths behavlor of unanesthetized cots recelving Intraventicular Injectlons of neurokInIn suggest that a catatonle state Is Induced. These observations will be extençed In an attempt to galn additlonal background Informatlon to gulde studles with human subjects concerning the role of neurokinin In the Imparlment of the highest integrative functions of the brain observed n In those with paychosis. Thus o number of agents wil! be examined in the search for antagonists and potentlators of neurokinln.

a) A book lergth monograph, tentatively entitled, summnorizing and reporting the prevlpus activities of this group will be prepored.

b) A revislon of the bool under way by Dr.

OURGSSANOMETHODS HNVOLVED

61-7

[PAGE 15]
Japusry 6. 1960

Enclosed please-find our check in-the.asount of \$14,614.75 vhich repre:ents the third paymont of the grant made to.your institution for work in Euman Ecology directed by La

Sincerely,

[PAGE 16]
Enclosed please find our check in the azount of \$9,614.75 which represents the second payment of the grant made to your Nedical College.for-work il rected by Dr.

Sincerely,

September 30, 1959

[PAGE 17]
Zoclosed pləase find our check in the apownt- of \$14,614.75
which rèpresents the first quarterly paucont or the grant árocted
made to your Yedical College for work i
by d Sincerely,

July 1, 1959

[PAGE 18]
Attached is the accounting for the period July 1, 1959 B through June 30. 1960. We forwarded directly te 1he sum of \$53.459.00 and held -back \$5.000.00.. This yas at the request of Dr.B wh o was desirous of having Dr. ork C vith his project. Dr.owas retired from the College and could not be but on their payroll.He thon became an emoloyee of the and was paid from the \$5,000.00 in D ccount.

61 61-11

September 19, 1960

[PAGE 19]
010 heicil Divisicn SUAMAARY OF EXPENSES ON OUNT POR ASCAL YEAR

Tetol Expondlnres \$31, 935.76
Amourt obllgoted for unpald billa end echaln. foe not yot deducted 466192
GRAND TOTAL 854 5799.65

Amcent rocelvod krom Soslety for the levovtigotica 859, 784. 35
(laaluctng badovoe certed ore fran prevlovs yeor) C 56,599.60
Tutdl chargw

-In addition to the, above the sum of \$5,000.00 was paid directly to Do In the form of salary in monthly installnents during this peri

Ths above accounting is a true statement of exponses on the above accouat as showed to me.

[PAGE 20]
I hereby acknowledge receipt of the following:

Cashierts Check No. A222106, in the amount of \$58,459.00 drawn on

61-13

[PAGE 21]
No.15

Cost Account 0525-1009.4912

Object Class

[PAGE 22]
MENORANDUM FOR: CHIEF, PINANCE DIVISION

VIA : rss/pudget orficer

SUBJECT : XXULTRA, Subproject 61, Invoice #5

1. Invoice No. 5 for the above subproject ia attached. Payment should be made as follovs:

Cashier check in the amount of \$58,459.00, dravn on Enk end made poyable to tho

2. Please forward check to Chief, Ts3/Chemical Diviaion Through TSS/Buiget Ofricer by Friday, 21 Auguet 1959.

-3. Thie is a final invoice. Hovever, since it is, anticipated that additional funds vill be obligated for this project, the files should not be closed.

ATTACEMENTS: Invoice & Certificatione

Distribution: Orig & 2 Addreagee 1 FASB/TSS

1319U6

1C CICC ARE AVARALE 50,198.00
9.502.75.902

37260.50 CET C525:L004: 4902

21 Auguet 1959

[PAGE 23]
CERTIFICATIONS

(1) It is hereby certified that this is Invoice f5 applying to Subproject 61 of MULTRA, that perforance is satisfactory, that services are being accomplished in accordance vith mutual agreemente, that a detailed agenda of the payments and receipts is on file in iss/CD, that thie bill is Juat and correct and that payment thereof has not yet been made.

Chief, TSS/Chemical Division

(2) It is hereby certified that this invoice applies to Subproject 61 under MULTRA which was duly approved and that the project is being carried out in accorlance with the memorandum dated 13 April 1953 from the DCI to the DD/A, and the extension of thie authority in subsequent memoranda.

Research Director

For services

INVOICE

\$58,459.00

[PAGE 24]
2 July 1959

MEMORANDUM FOR: COMPTROLLER

ATTENTION : Fiaance Dlvislon

SUBJECT

: MKULTRA, Subproject 61, Addltional Authorizatlon ê\$S

Under the authority granted in the memorandum dated

13 April 1953 Írom the DCI to the DD/A, and the extenaion of

this authority in subsequeat memoraada, Subproject 6l bas

baen approved and \$38,360.80 of the over-all MKULTRA project

funds has been obllgated to cover the subproject's expenses.. This

obligativa of funds should bo charged to Allotment 0525-1Q09-4902.

APPROVED FOR OBLIGATION OF FUNDS:

Research Director

Date:

Dlstribution: Orig & 2 - Addressce

1-TSS/OC

1- TSS/FASB

2-TSS/CD

61-760

TSS/CD

[PAGE 25]
29 June 1959

MEMORANDUM FOR:COMPTROLLER

ATTENTION : Finance Division

SUBJECT : MKULTRA, Subproject 61, Additional Authorization #4

Under the authority granted in the memorandum dated

13 April 1953 from the DCI to the DD/A, and the extension of

this authority in subsequent memoranda, Subproject 61 has been

approved and \$20,198.20 of the over-all MKULTRA project funds

has been obligated to cover the aubproject's expenses..This.

obligation of funds should be charged to Allotment 9-2502-75-902.

TSS/Chemical Division

APPROVEDFOR OBLIGATION OF FUNDS:

Research Director

Date:

Diatribution:

Orig & 2 - Addreasce.

1. TSS A

2 - TSS

TSS/CD/A

[PAGE 26]
January 9. 1959

Enclosed please find our check in the amount-or \$14,614.75
-which reoresents the third quarterly peymnent of the grant givon
to th College to support the work of Dr Sincerely, C

[PAGE 27]
i te7s examized ad approved the submitted expeditureso

TSS/Cheatcal Division

[PAGE 28]
BUDGET 1959-1960

[PAGE 29]
: Continuation of Project MULTRA, Subproject 61

1. The purpose of this subproject is the continued support of Dr tudies on brain damage in human beings. Work in this field has made good progress during the past year. Highlights re- this field has made good progress during the past year. Highlights re-

lating to this are quantitative clinical demonstrations of a much more precise nature than was ever-before possible of the actual performance deficit brcught about by suppeession of the-activity of various areas of the central nervous system. New methods of measurement-of-circulatior changes involving the use of implanted thernistors of a very sensitive type have served to reduce the uncertainty of many of the experiments in this fieldof research.

2. During the coming year it is anticipated that many of the investigative techniques worked out in the past will begin-to show their effects in terms of a vastly increased rate of significant data production.

3. This project has been reviewed and approved by the Board of Directors of the It should be noted that Dr Eceives no stipend under the attached budget and that several portions of the work to be covered will be supported by other than government sources.

4. The cost of the prograa-for a period of one yeart starting
1 July 1959 is estimated to be \$58,459.00 ill be used as a cutout for transferring the money of the funds required for one year \$20,198.20 is
being obligated at this time. Charges should be made against Allotment 9-2502-
75-902. Remainder of funds required vill be obligated vhen FY60 funds becoue angrad
available. 7 süthani

E2 IMPDET; CL BY 187475

MEMORANDUM FOR: THE RECORD

[PAGE 30]
has requested submit to them a summary accoun'ing on an annual basie of all monies received frot Also, it has been requested that any unexpended funds be returned as soon as possible upon the close of the grant year.

6. Title to any permanent equipment purchased by funds granted the University shall be retained by the University in lieu o higher overhead rates.

7. In connection with travel under thie project, it is agreed that the Agency will accept the travel-documentation and accounting which conforn with the practices of the University.

APPROVED FOR OBLIGATION OF FUNDS:

APPROVED FOR ADDITIONAL APPROPRIATIONX OF \$38,360.80.

Dato;7/2/59

Attachment: Budget

Distribution: Original only

E2 ILPDET; CL EY 187476

E3 IMPDET; CL BY 137475

[PAGE 31]
RECEIPT

I hereby acknowledged receipt of the following:

[PAGE 32]
MEMORANDUM FOR: CHIEF, FINANCE DIVISION

TSS/Budget Officer

SUBJECT

: MKULTRA, Subproject 61, Invoice f4 Allotments 8-2502-10-001 aad 9-2302-75-902

1. Invoice No. 4 for the above subproject is attached. Payment should be made as follows:

Two casbler's checks, one ln tho amouat of \$35,567.96, obligated under this aubproject during FY 59, and one in the amount of \$22, 891.04, obligated under thla aubproject durlag. £Y 58, both drava op A ah and made payable to

2. Pleaae forward the chacks to Chief, TSS/Chemical Divlsion through TSS/Budget Cfficer by Friday, 10 October 1958.

3. Thts ie a final iavolce. However, since It ls anticipated that additional funds will be obligated for this project, the files should not be. closed.

Altachments: Invoice & Certifications

Dietributlon; Qrig & 2 - Addresece TSS/CD Oct 58) A

御

2 October 1958

[PAGE 33]
For services

CERTIFICATIONS

(1) it ie hereby certifled that thls ls Invoice f4 applying to Subproject 61 of MKULTRA, that performance is satisfactory, that sorvices are being accompliahed in accordance with mutual agreemente, that a detalled agenda of the payments and receipts is on file in TSS/CD, that thie bill ie just and correct and that payment thereof has not yet been made.

Chief, TSS/Chemical Diviaion

(2) It is hereby certified that this lnvoice appliee to Subproject 61 uoder MKULTRA wbich was duly approved.and that tho project is being carried out in accordance with the memorandum dated 13 Aprll 1953 from the DCI to the DD/A. and the extension of this authority in subsequent memoranda.

Research-Director

INVOICE

\$58,459.00

[PAGE 34]
October 2, 1958

Enclosni please find our check in the arount of \$14.614.75 vhich reoresenta thesecond-quarterly payaent of the grant piven to the ollege to supcort, the work of Dr

Sincerely.

[PAGE 35]
Enclosed please find our check in the anount of \$14,614.75 which represents the first quarterly payment of the grant y givento th llege to suprort tho work of Dr. The total grant for the period July 1, 1958 thro0gh Jwe 30, 19591s-\$58,459:00.

Sincerely

July 7, 1958

[PAGE 36]
0

Cost Account . 9..7502.15.902

61-27

[PAGE 38]
HEMCRANDUM FOR: COMPTROLLER

ATIRNTION

1 Finance Division

8UNJ2CT

, MULTRA, Subproject 61

Under tho authority granted in the remorandua deted

13 April 1953 frõa the DCI to the DD/A, an1 the exteneioa of

this authority in subsoquent menoranda, Subproject 61 has been

approved end \$35,567.96 of tho over-all MKULTRA project funds

has been cbligated to cover the aubproject'a expenses.Tbis

obligation of funde should be charged to Allotoent 9-2502-10-001.

APPROVED POR CRLIGATION OF PUNDS:

J CERTIFY THAT FUNDS ARE AVAILASLE 福 GLHATICN PRNHCE N 67 GNARS1ANCN. 0.2222-0-431 Av CirER

Distributioal Orig & 2- Aidrescee

61-29

1 July 1958

[PAGE 39]
VIA : TSS/Budget Olficer

SUBJECT : MKULTRA, Subproject 61, Invoice f4 Al1otmeota 8-2502-10-001 and 9-2502-75-902

1. Invoice No. 4 for the above subproject is attached. Payment should be mnade as followat

Two cauhler's checks, one in the amount of\$35,567.96, obligated under thls subproject during FY 59, and one in tho amount \_of \$22, 891.04, obligated under this eubproject during FY 58, both Y/ drawn on a bank and made payable

2. Please forward the checke to Chlef, TSS/Chemical Diviaion through TSS/Budget Officer by Frlday, 10 October 1938.

3. This la a final involce. Howover, since it le anticipated that addltional funds will be obllgated for thls project, the flles ohould not bo closed.

8 983 (02712 600.1 25601 172 22,891.04
889 c00067 600.125027-96217.235.56776
d cisl 35567.96 22,89104
C- Cask 07720

1

2 October 1958

MEMORANDUM FOR: CHIEF,FINANCE DIVISION

[PAGE 41]
30 Juno 1958

MXORAIDM FORI COMPTROLIAR

ATTEETION

1 Finanoo Division

BUBJECT

1L, Sbproject 61

Uoder the authority granted in the meporandua dated

13 Apri1 1953 froa the D0I to the DD/A, ani the exteneica of this authority in subeequent momoranda, Subproject 61 baa been approved end 2,891.04 of the over-all MULTRA projeot fundo bas been obli zated to cover tho subprojeot's exponses. This obligation of funde should be chereed to Allotzent, 8-2502-10-001

APPROVED FOR CRLIOATION OF FUNDS:-

1 CERTFY THAT FUNDS ARE AVAILABUE ORUGATON REDE27 CHARGEC

Dator,

Distribationt

61-32

[PAGE 42]
1 July 1950

MSHOCANDH POACONTAOLLSR

ATTCNPION

1Pinonce Divioion

SUNJEOT

, projet 61

Uoder the authority grnted in the Eoaorondus dated

13 April 1953 froa the D01 to the D0/A, ani the extension or

thie authority in auboequent occorando, Subproject 61 has been

approved and \$35,567.96 0f the over-all ULA project unds

has teen obligatol to cover tho subprojoct's expoases.This

obligation of funie phouli bo .argod to Allotoent 9-2502-10-001. 75-902

T33/Cbeaica1 Divieion

APPROVED FOR OBLIOATIOT OF FURDS:

Date:.

Dietribution:

Orig & 2 .Mdressce

1 - TSSI

2 - TSS】

TSS/CD/(30 June 1958)

[PAGE 43]
IEYORANDUM FOR:COMPTROLLER

ATIENTION

t-Fisance Divieton

SUBJECT

1HULTRA, Subproject 61

. Vader the duthority grantod in the repcrontum deteli

13 Apr11 1953 frou the DCI to the Do/s, and tho extenaion of thia authority in pubscquent mecoranin, Subproject 61 ban been approved end \$2,891.0h of tho over-a1l N0ULTrA project fun10 has been cbligated to cover the subproject'a axpenaes. This obligaticn or funds should bo charged to Allotzent -2502-20-001 75-907

APPROVED FCR OBLIOATION OF PUNGI

feseorch Director

Dete:.

Distribution: Orig 4 2 - Adiresooe

TSS/CD/(30 June 1958)

30 Juno 1958

[PAGE 44]
MEMORANDUM FOR:TEE RECORD

SUBJECT :Continuation of Project MKULTRA, Subproject 61

The purnose of this subproject is the-continued support of Dr tudies on brain damage in human beings.- The attached proposal outlines progress in this field to\_date and indicates the plans for new work to be done during the coming year.In general, the current and future emphasis of the program will involve studies of metabolic and biochemical changes associated with impaired brain function related toother types of brain damage than actual tissue loes.

D 2. Thia prolect has been revieved and approved by the
Board of Directors- It should be noted that Dr
ceives no stipend under the attached budget and that several portions of
the work to be covered will be supported by other than government sources.

3. The cost of the program for a period of one year starting 1 July 1958 1s estimated to be \$58,459.00 will be used ag a cutout for transferring the money ts Charges should be made against allotment 0-2502-10-001.

has requested to submit to them a sunmary accounting an annual basis of all monies received fro Lso, it has been requested that any unexpended funds be réturned as sooh as possible upon the close of\_the-grant year. B

5.Title to any permanent equipment purchased-by funds granted the University shall be retained by the University in lieu of higher overhead rates.

6.In connection with travel under thia project, it is agreed that the Agency will accept the travel docurentation and accounting which conform with the practices of the University.

APPROVED FOR ORLIGATION OF FUNDS:

61-35

E2 IMPDET; CL.BY 187475

Distribution: Original only

[PAGE 47]
November 15, 1957

Enclosed is the Society's check in the amount\_of \$50,000.00. Thia sum eoresents the first half paynent of the grant given supoort the work of Dr The second half payuent will be made In January 1958.

601-37

[PAGE 48]
I hereby acknowledge receipt of the following:

Cashier's Check #A181201, in the amount of \$30, C00.00 drawn on\_the Hated Noyember 8, 1957, payable to B

Cashier's Check /Al81200, in the amount of \$20 000.00 drawn on the ted November 8, 1957, payable t B

Date:13 November 1957

RECEIPT

61-38

[PAGE 49]
26 October.1957

MEMORANDUM FOR: CHIEF,FINANCE DIVISION

TSS/Budget Officer

MKULTRA Subprojact 61, Invoico No. 3, A11otmept 8-2502-10-001

1.. Involce No. 3 for the above subproject is attached. Payment should be made ae followei

Two çaehler'e checks, one in the amount of \$30, 000.00, and ono in the amount of \$20, 000. 00. both drawn on a bank and mado payable to

2.Pleaso forward tho checke to Acting Chief, TSS/Chemical Divialon througb TS3/Budget Officer by Friday, 8 November 1957.

3. Thls is a final invoice. A total o1 \$50. 000. 00 was obli gated undor this aubproject during FY 58. However since it is anticipated that additlonal funde will bo obligated for this project, the files should not be closed,

Attachmente: Invoice &Certifications

Dietribution:

Orig & 2 -Addresaee 1 -Comptroller

Dn. 283 000772 600.1 3502-4-001 112 # 50,400.00
CR. \$50,0co.v0

61-39

[PAGE 50]
CERTIFICATIONS

(1) It le hereby certified that this ie Invoice No. 3 applying to Subproject 61 of MKULTRA, that performance has been eatiefactory. that the services have been accompliehed in accordance with mutual agreemente, that a detailed agenda of the payments and receipte ls.on file in TSS/CD, that this bill ie juet and correct and that payment thereof has not yet been made.

Dato:

Acting Chief, TSS/Chemical Division

(2) It is hereby cortiflod that this invoico applied to Subprojoct 61 under MKULTRA which was duly approved and that tho project ie being carried out in accordance with the memorandum dated 13 April 1953 from the DCI to the DD/A, and the oxtenslon of this authority in subaequent memoranda.

Dater

INVOICE

61-39

For servicee

\$50,000.00

Research Director

[PAGE 52]
17 Octobor 1957

MRMORAND FORT COMPTROLLSR

ATMNTIoN Finenoa Divioton

SURICT MXULTRA, Subprojoct 61

Unter tha authority granted in the pcmorandus dated 13 Aori1 1953 frca tho DCI to the Io/A, anà the oxtenoioa of thie authority in subsequont memorania, Subproject 6l bas been.approved and \$50.000.00 of tho over-a11 k0ULRA project funuls hao boec obligated to cover the subproject' expensos. Thig obligation of funio should bo chargel to A1iotrent 8-2502-10-001.

Aetiog chier rsS/Chenical Diviaion

APPROVED POR OBLIGATIOE C FUNOSI

Recenroh Dirogtor

Dato 121150

Diatribationt

Orig & 2 Addres36e

1TSS/00

1 -TSS/SRB

TSS/PASB

2 --TSS/CD

[PAGE 53]
Study of Highest Integrative unotionat Frogreas Report, and Proposal for the Cosing Year.

I, Presant Stetus of the Study!

The inveptigatione of the higbost integrative-functions are fundamentally aimed at increaaing our unierstanding of the finctiona of the humen cerebral hemispheres in overall adeptive behavior.\ They erose out of our laborstory and clinical experlonce during the past twenty yerre, end ospecially out of our intereat in the phenomena exhibitod by men exposed to extremely thrsatening life situetionsl end they were initiated during the period when we were investigating the untovard etrecte of Communiat police procedurea.

The body of evidence acoumuluted during theso atudios indlicated that under extremoly odverse oircuaatances zen may develop syaptoas cliñidally dirficult to diatinguish fron thor produced by gross brain damage or by agente that impair cerebral motabolismt lack of discriaination,. poor tolorance of frustration, beightonod suggeatibility, illogicel thinking, broakdowa or defense mochanisns, mental clouding, disorientation, and frank delirlua. The initiel efforts to elucidato those phencuena began-sovoral yoars sgo, and have largely boen brought to a conolusion during the past twolve monthe,

Tho firat step in this study wes the systenatic investigatlon of the highest intagrative functione of people who had suffered danage to thoir cerebral heaisphores, the amownt and locatiou of wlich waa known aa preolsely as posoible. During the course or four years, 250 such people were studied. In ordor to provide then with the videst poesiblo opportunity to expose their defeots in funotion, mary srens of their adaptive ectivity were explored, both outside and within the laboratory. Subjecte were obsorved in thoir performance on clinical sssay procodures, including sose thet are well known as well ss cthera that were newly devised. Thoy wero exposed also to procedure

61-41

BTUDY PROGRAN

[PAGE 54]
especially designed to inveatigate aroes of behavior such as perseveration, which were of epecial interest. . In addition to this, epoh waa atudied extensively by the uaunl olinical, neurolosical, and payohiatrio mathoda. Finally; an extensive review was made of bis lire history; both bofore and arter his brain injury. with opecial attention to bls performance in the xore coaplex aroas or his lire edjustoent, such as hia capacity to doal with tho requiravents and challenges arlaing in bis fanily and in bis Work,

Tha second atep in the investigation wae a aiailar study of ontensibly intect people with no known gross-dansge to thoir cerobral honispheres. Two groupe or such people have been investigatedt So paople with disordere such as chronio anxioty, tension, depression, and schizophronia, and-25 peopla with bodily illnesses such as poptic ulcer, ulcerative.colitis, or migraine headaches.

II. Finiings to.datel

From the integration of all of the data obtained froa poople with damage to the cerebral hextapheress it bas been possible to defino soas of the edaptive functione-cr the human that are priaarily subporved by the reopallius. Thesa have been called the "highest intogrative funotions" of the organise, and they have been placod in four general categorlea, vist

(e) The intaot neopsllius énables a man to expreas his appetites, drivãe, and fealings in a manner spprcpriate to lire in a coaplex sookety.

(b) It provides hia with mschanisne for the achiavemont of oonplox goals (learning, semoryi logie, ote.).

(c) It erables hia to maintain a bigh degrve of tolerance for frustration and fallure when confronted by conflioting drives, and to recover proeptly from the effects of frustration and failure when they oocur.

//(d) It provides bix with the-cepacity to saintain effective and well-

-2-

[PAGE 55]
modulated defonso reactions (i.o., repression, denying, pretendins, rationalization, blaming, witbdrawal, phantasy, depereonalliution, obsessive-oompulaive behavior, and bodily reaction patterns involviug alisentation, reepiration, motabolise, otc.).

evidenoe froa tho study of thw brein-damaged indicates thet these highest intozretive tunctions ero not localleed within the bemispheres. hey fsll ofr in a graded fashion dependont upon the amount of honiaphere tisaue that ia lost, ani without regari to its location. Moreovor, they lall ofr lons beforo lose bighly organized funotions, such as simple aomory, the ability to oalculate, or the ability to carry out tasks of soze couplexity laarned prlor to the brain injury. are lost.

Evidonce fros the study of tho chronically anxious,: tonse, depressed, and schizopbrenio aubjocts indicates thet thoir bighest integretive Cunctlong. as fudzed by their portoreance on the tosts and in their life adjustsont, falls ofr in a mannor not distinguishaole fron tbat of poople whs have suotsined brain damege. They can, of course, be distinguishod fron poople with groas brain-daaage by the abaence of localising neurolozical signa, and by tho intectress of som of their loss complex Cunctionel but in their inabillty to expreas their feelinge sppropriately, to utilize thoir-goal-sohioving mechanisas effectively. to tolerate fruatration ani failure, and to meintain well-moduleted defense reaotions, they are indiatinguishable from those who have austained diroct damage to their broins. In many inatanoes thsir functions sre iapaired to a degreo equivalent to that produced by a large losa of benisphere tissue (100 grans).

Siniler degreua of impairoent of the highest integretive functions bave been found in peopla-with diaturbances of bodily adaptive roactlon\_patterns auch es peotio ulcer, which are intiratoly tlod up with the gsneral lifo adjustment.

O

小

[PAGE 56]
Thege two groupe of chronically ill people, in ahort; shor manireatationa of an iepairment of their-cerebral hemiapheres. Jecause sone of the diaturbances of these people are transient, the impalrment of their heniapharas is to aone extont reversible and ia anid to be "runctionaln; but since many of their illneuses, like schizoohronia, ulcerative colitia, and chronio psychoneuroses, and their accompanying failurea of life adjuataent, are notoriously wrrealtting, it seems quite likely that sozo of these poople have, in effect, & severe and permanent impairment of their neopalliun.

This evidenose of sevare, and possibly permanent, impeirmont of the Cunotion of the cerebrel hemispheres raleod the question of whether other, and chemically detectable, evidences of altored brein motaboliam might be found in people in whon, up to the present, only symptoas of diaturbed function had bean described. It aeemed possible:that subatances assoclated with diaturbod cerebral metabolisa might appoar in the spinal fluid, and aight bo found there in pooplo with dige turbanoes of cerebral Tunction.

Therefore, the-initial search was direoted tovard tho detection, in tha apinal fluid, of substances that\_might be rolated to disturbod brain mataboliam.

Ihis investigation bas been unoxpectedly fruitful. ay exposind to boel globulin spinel fluid taken froa people with known damage,to the cerobrue, it has been shown that theso spinal fluide oontain a subetance with the characteriatics of an enzyne, which breaks down the globulin to a polypeptide, This polypeptide has not been identified chemically, but in biologioal prepara tions it has many of the characteristica of a polypeptide found in bliater fluid and other inflasnators exudatos, which has been called "bradykinin".

This onzyae has-boon found to be prosent in the spinal fluide of 45 out of 50 people with varlous forms of active brain damage.It has boon found also in the spinal fluids of 13 out-of 15 people during attacks of vaacular : headacho. It has not been found in\_the\_spinal flulds of 50 persons who

61-4/1

[PAGE 57]
had no evidenca of diseasd of the oentral nervous systen, It wes lourd in the fluid of sone persons wbo woro oxperiencing much strcss.

or perbups groatost interest, it has baen found in the spinal Tluids of 45 out or so poople with activo schizopbrenia, but withoyt other ovidence of disoa9e. …  -

e bolleve that the finiinz or thle enzyne-like aubatance and polypoptides undor the circunatancea deaoribed supports other evidence that metabolio diaturbances occur in the brains of people with headeche and schizophrenie. e expeot that the sane subatance will bo found in the spinal fluids of people with other chronic diaturbances-of thair highest intogrativo Punetions.

It ie well known that prolound disturbancos of the highest integrative functions, secompanied by pronounced disturbances of sood, thought, and behaylor, may ba produced in poople by exposing thea to environsonte\_to which-they chn make no adequate edaptation, sucb as coneontration caspe, or prison procedures aimed at interrogation snd indoctrination. Therefore, it eeamg reasonable- to infer that exposure to suoh a aituation in itself produces en\_iapairmont of cerebral heniaphere-Cunctionj and that this impeirment cay sometimas bo very grave.

IIi. Proposal for\_the Coaing-Yeart

1.  monograph titled is plannod for complotion during is58. The major goal of this publicstion will be to define the defects in hlghest lovel adaptive capaoity that ooour with disease of the reopalliua, end to illustrato bow those defacts aro glmilar to those produced by prolonged exlstonce in an unadepted state. It ia intendod thät the deacriptlon of the oompononta of the highest integretive funotions will be comprehenaivo enough-to take into account the various eloments of diseases

O 61-41

O

[PAGE 58]
charactorlzed oy prolonged diaturbences of mood, thought, and behsvior.

This project vill be undertaken priaarily by [r Bwith an editorial éseistant.

2. In order to assoss-further tho highest intogrative Nwictiona or s poople with chronio illnesa not ostensibly involvin? the central rorvous:systea, a study of a crrefully chosen group of yourg people with ciabotes rellitus vill ha undertaken. Date with regard to their health, personalities, and interaotieo with their social onvironmont will be gathored hy rerhora or the staff unier the diroction of sing nethods sixilar to thoso usedin the study. upport tor thia investigative afrort in genoral is ceing sought fren other sourcoai but for tbe speclal psycholegicel tssting neeced for this aspeet of it a Nuli-tia psychologlcsl techniciar: and a psychologist vill be recuired, V 3.he tollov-up-study on the vill likewige-provide an-opportunity for the study of their-highest integrative functiona, snd an estimate or the influence of their life experlences upon this. The sethods will be thoso that bave been describedi zost of ths necessary dete ero already aveilsble, and only a modorate amount of additionel. testing need be done.

h. A sisilar study, using a carofully solooted group,of working wonen, lergely honogenoous in ita composition, will bo carrled out, Recorda of health attendance, and perfornance on tbe Job, covoring pariods of more than twenty years, are aveilable for theae woman. Those to be teeted will bo seleoted to inolude sose with records of outatandingly xood bealth and porfornance, yone with outatandingly poor bealth and performance, and sone whoso perrormance was near the redian in these respeots. A lerge part of the coat of thia projeot also will be borne by other aaurces

5. In order to make a further asseassent of the effeot of demsge to the noopalliun upon general health, a group of thirty subjocts, with focal removala

61-41

[PAGE 59]
of major and ninor portions or the cerebrel henisphorvs will bo uxaained to ascertain the illness epluole rate or theae people before and after the damage was custained. Intereat will also be centerod on the mánror in vhich this dwmuge to the cerebrua altored the incivlduai's perceptiona of the threate anc challengos prosonted to his by bis environmnt.

o. ho studiea of the proteolytlo onzyms in apinal fluid will bo continuod, with toreo leciato. 6oe.s1

à, ho coyetopant of a siaole,roadily repeatablo method lor the
qusntitative vatimation of the proteolytic dctivity or splnal :luld. ite pressnt
blo-asssy techniqusiis-cuabersoae ani techuically deauuilng. A siaplu chsnlosl
test may te possiole. il auch a ostbod san be dovolopad, a large sories of
messuremante.of protoolytic activity i. spinal Tluid vill boandertakon, using
epecinons obteinej troa th neurologioal. oerzises or uad Aospital, 2oepital, and poesibly the oooltel.

wwmwab. lho tporeiaai of tw stgnirlcanco of the cosorvation that increasod umounts of proteolytlo zotivity ae preaont un spinsl-cluid at aons tiwos, and in sono peoplc. re approtch to this proolen will os trough ssvertaining the effect oi à sterila injootzole "anti-brodyainin" agent, In tho tora of chymotrypsin. Tbe effoota or intravenous, intrazusculer, ani perhspa intrathooal injections-or this and similer substanoos, after sulttbie prceutiors have teen taken to ascertein the safety or such procodures, will ce unáarteken in pecplo vith nigraine headacbe and echisophrenie,

o. Pharaaçologioal studios will be undertaken in ordor.to establish whethur er not Uho protuolytio enzyme observed is idontieol with s-xnown brcdykinin lsratit y.

7. ittoapts to dvvolop new mothods for tha studiy\_of\_tho bigbeat integrative fwnetions will continuet ooe motbod now boing corsidered is that of conditloning

61-11

[PAGE 60]
8. Investigations:of the local curabral ciroulation will likewise be continusd,

the alectrooncephalographlo response in brain-dassged persons.

6+-411

[PAGE 61]
9UDOzT --Study of Higbost Integrative Punotions FY 1958-1959

61-42

[PAGE 62]
E2 IMPDET CL-BY-187475 MEMORANDUM FOR: TEE RECORD

SUBJECT : Contimuation of Project MKULTRA, Subproject 61

The purpoaa of this subproject ia the continued support of C rudies on brain damage in human beings. The Osal Cutlines progress in thie field to date and indicates the plars for nev vork to be done during the coning year. In goneral, the current and future emphasia of the program vill involve studies of metabolic-and biochemical changes associated with impaired brain function related to other types of brain damage than actual tissue loss.

2. Thie project was reviewed and approved by the Board of Directora t the meeting of 1l March 1957.' It vill bo noted that the attached budget indicates an expenditure of \$61,805.00. Dr a8 C agreed to obtain \$11,805.00 of this froa other than Agency urceb, lovering our contribution thereby to \$50,000.00.

3. The coat of the program for a period of one year starting 55,459.00 1 July 195761s eetimated to bo \$50,000.00 vill be used as B cutout for tranefel the money harges should be made against allotment 8-29

has requested o submit to them a summary accounting on en annual basis of all monies received fra Also, it hag been requested that any unexpended funle be returned ag goon as posaible upon the close of the grant year.

5. Title to any peraanent equipment purchased by funds granted the University shall bo retained by the Univereity in lieu of higher overheal rates.

6. In connection with travel under this project, it is agreed that the Agency will\_accept the travel documentation and accounting which conform with the practices of the Univereity.

APPROVED FOR OBLIGATION OF FUNDS:

Acting Chfer TSS/Chemical, Divieion

Dato tel.21-1952.

Attachment:Propooal & Budget

Dietribution: Downgreded to by authority of: 187475 Original Only - TSS/CD nta: June 1977

61-43

[PAGE 63]
roteot - Plens for the Coning Year. July 1957- June 1958

The investigations in Brain Funotion initiated in the Program were based on the postulate that the funotions of the humsn brain and possibly its otructure may be damaged as a consequence of prolonged stress. This thesis is now almost fully documented. Early 1n-the study, impairment of the highost integrative funotions was defined through the elaboration of methods for the atudy of highly seleoted subjeots vith loss of known amounts of tiosue from the cerebral hemispheres. These persons vere-studied by a large aggregate of. quantitative behavioral indicators and by means of extensive information from their families and their associategIt was then demonstrated that the highest integrative funotions are impaired: to a degree closely linked to the mass or tissue loss, regardless of site, and in a manner determined by the subject's development, previous life experienoe, and prevailing high level adaptive reactions.

These mothods were next applied to several groups of persons who had suffered prolonged streas. The evidence gathered indicates that the brain is vulnerable when sevore threat is prolonged, and may be damaged when there is a failure in high level adaptation for long periods. Those persons who perceived themselves as most threatened, and who exhibited the most serious abreaotions, were those who\_were most severaly impaired in their highest integrative functions. Such defects wore somotimes major and in some instanceg inoompletely reversible. To explain suoh defeots, a thesis currently entertained by the laboratory is that the observed dysfunotion may be related to neurohunoral and biochomical aspects of inapproprlate and faulty metabolism that are capable of investigation.

The program for the ourrent year will inolude extensive-further documentation of the above thesis with explorations of the biologic mechaniams behind these damaging procesaes. It is hoped that, by so doing, ways and means of avolding and eliminating the above dosoribed abreactions will be forthcoging.

0.6

[PAGE 64]
The personnel and equipment will remain the same.: The funds involved are detailed on the attached sheet.

[PAGE 65]
61-44

[PAGE 66]
Amounts Obligated in 2Y 1955-56 but Pald in FY 1956-52
Equipment 399.55
Supplies 352.76
Reference Library 23.29
Miscellaneous 120,09
Telephone,electricity-&-exterminator 190.79
Travel (inoluding taxis) 316.42
Supprio 520.55
Reference Library 24.86
Miscellaneous 57.99
Salaries (includ: Soc, Sec. and S% Retire,
Plan) 45120.02
Special payments 285.41
Travel 435.18
Administrative Fee 2.041.95
roject F
3.75
Rooms (for interpreter-&-informants) 350.00
Moals. Taxis & Misc,for informants 1,165.00
Informant Fees 1,400.00
Reference Library 11.85
Salaries (includ, Soc,-Sec. and 5% Retire.) 11,630.65
Special payments 5,400.98
Travel 21,22

Ront forB

Obligated for Administrative\_Feo 6,300.00
Total unoaid bills (including security on 2.051.00

\$1,402.90

SUMMARY OF EXPENSES ON

19,983.45 6.675.00

CCOUNT FOR FISCAL YEAR 1956-571

[PAGE 67]
Receipt-is hereby acknowledged of the following four checks:

Treasuperls-check No. 1-152550,dated January.23. 1957 drawn on the the amount o1 6, 512,50

Cashier's check No. A106835, dated January 14, 1957, E drawn on in the anfount of \$b, 512.

Official check No. 209-271130, dated January 14, 1957; drawn. o in the amount of \$10,000.00.

Casbier's checkNo. DM39739, dated January lt,-1957 drawnon the the amount 0r\$16,050.00.

Q6146

Receipt .#t

[PAGE 68]
Receipt

. Recelpt is hereby acknowledged of the following four

Treasurer's check No. 1-152550, dated January 23, 1957 drawn on the the amount of \$6, 512.50.

Cashier's check No, A106835, dated January 14, 1957, drawn on in the amount of \$6, 512. 50.

Official check No. 209-271130, dated January 14, 1957, drawm on n the amount of \$10,000.00.

Cashier's check No. DM39739. dated January 1l, 1957 in drawn on the the amount oT\$T6, 050.00.

61-47

Date:

[PAGE 69]
MEMORANDUM FOR: CHIEF, FINANCE DIVISION

TSS/Budget Officer

SUBJECTI

MKULTRA Subproject 61
Invoice No. 2, Allotment 6-2502-10-001

1. Invoice No. 2 for the above subproject Is attached. Payment should be made as follows:

Cashlarta check fn the amount of \$6, 512.50, drawn on a ank, ahier's check in the amount of \$6, 513. 50, drawn on a Bank ashleala eheck in the amount of \$16, 050.00, drawn on a ank, ghterig check in the amount of \$10, 000.00, drawn on a Dank.

All four checks should be mado payable

2. Please forward the checks to Chlef, TSS/Chemical Division through TSS/Budget Officer by Friday,|18 January 1957.

3. Thts is a final Involce. A total of \$58, 612,00 was obligated under thts subprolect during FY 5s. However since it is anticipated that additional funds will be obligated for this project, the flles should not be closed.

Attachments: Invoice-& Certificatlons

61H8

4 January 1957

SIDNEY GOTTLIEB Chief, TSS/Chemical Division

Orig & 2 - Addressee 1Comptr011er 81.886-002671-600.1-2537-10-001-17.1-439.071.06 G. Cosh 39,075.00

[PAGE 70]
SUBJECT:

I hereby acknowledce-reeeipt of tne following:

#209.371130

10,000

1.152550

6512.50

D4 39739

A106835

16,050.00

6,572,50

Please return. signed\_copytiestof this\_receipt

FORM NO. 36.65
MAR 1949

MEMORANDUM RECEIPT

FROM:

[PAGE 71]
Receipt is-hereby-acknowlodged of the following checkt=

Cashier's Check, -No. M24715, dated December 13, 1936, in the

[PAGE 72]
\$39,075.00

CERTIFICATIONS

(1) It is hereby certified that this is Involce 2 applying to Subproject 61 of MKUL/TRA, that performance has been satisfactory, that the services have been accomplished in accordance with mutual agreements, that a detailed agenda of the payments and recelptsils on file in TSS/CD. that this bill is just and correct and that payment thereof has not yet been made.

Chtef, TSS/Chemical Division

Date:

(2) It is hereby certified that this invoice appltes to Subproject 61 under MKULTRA which was duly approved and that the project is being carried out in accordance\_with the memorandum\_dated 13 Aprll 1953 from \_the DCI to the\_DD/A, and the extension of\_this authorlty in subsequent memoranda.

61-51

INVOICE

For services

[PAGE 73]
6 December. 1056

MEMORANDUM YOR: CHIEF, FLNANCE DIVISION

VIA:

TSS/Budget Ctfleer

SUBJECT:

MKULTRA Subproject G1, Invoice 1
Allotment 6-2502-10-001

I. Invoice No. 1 (s attached covering the above subproject. Payment should be made as follows:

Casbier's check 1o the amount of \$10. 537.00, payableto drawn on a Tocal

2. The check should be lorwarded to Chtef, TSS/Chemical Diviston, through TSS/Budget Officer, no later than Thursday, 13 Docember 1956. Otber invoices will follow.

SIDNEY GOTTLIEB Chiet TSS/Chemical Diviston

Attachments: Invoice-and Certifications

Distribution: Orig & 2- Addressce 1- Comptroller TSS/KASB 2 -FSS/CD

2572 1350102-101 6-2562.10.001

TSS/CD (6 December 1956)

CHEOKOISHE AMOUNT OE ES RECEIVI 1

G1-52

[PAGE 74]
CERTIFICATIONS

(l) It is hereby certified that this ls Invoice. 1 applying to Subproject\_61 of MKULTRA, that performance has been satisfactory, that the servlces have been accomplished in accordance with mutual agreements, that a detailed agenda of the payménts and receipts\_is on\_file in TSS/CD, that this bill is just and correct and that payment thereof has not yet been made.

Date:

(2) It is hereby certified that this invoice applies to Subproject 61 under MKULTRA which was duly approved and that the project is belng carried out in accordance with the memorandum dated 13 April\_1953 from the.DCI to.the DD/A, and the extension of this authority in subsequent memoranda.

INVOICE

\$19,537,00

[PAGE 75]
BUDGET:

[PAGE 76]
MEMORANDUM FOR:THE RECORD

SUBJECT :-MKULTRA,Subproject.61

1. Subproject 61 is being initiated to support the brain located at the B studies of Dr.

2. The scope of Dr rogram will encompass the following phases (see attached proposal for detailed discussion):-

(a)To systematically cotlect and evaluate current research on central nervoussystem-function and structure in-order to understand better what types-of research on modification and exploitation of CNS function will be most productive.

(b) To assess the elements of frustration adaptation by studying the reactions of brain damaged and non-brair damaged individuals·to artificially\_induced frustra tion designed-as à prototype-of certain situations-commonly-encountered in nature,

(c) To evaluate these reactions to see to what extent frustration adaptation can be prevented, postponed, modified and predicted.

61-54

by-authority-ofi-187475 dato:,June1977

DRAFT:

22.June 1956

22IPDST;CL BY-187475

[PAGE 77]
(2)

50,000.00

3. The cost of the program for a period of one year B starting 25 June 1956 is estimated to be \$58r6-13,00 ed as a cutout for trafisierring the money to Charges should be made against altotment 2502-10-001 ：

fogubmit to them has requeste, a summary accounting on an annuat basis of all monies received fron Also, it has been requested that any unexpended funds-be returned as soon as possible upon the close of the-grant year.

5.Title-to any\_permanent equipment purchased-by funds granted the University shall be retained by the Uni versity in-lieu of higher-overhead rates.

6." In conneetion-withtravel under this project, it is agreed that the Agency will accept the travel documentation and accounting which conform with the practices of the University.

APPROVED FOR OBLIGATION OFFUNDS APPROVED:

Attachment: Proposal & Budget

Distribution: Original Cnly -TSS/CD

61-54

[PAGE 78]
261956 Sebpoyed 11 58612.00 58612.00 10 1EG 19537.00 39075.00 39075.00

[PAGE 79]
MEMORANDUM FGR: COMPTROLLER

ATTENTION 1 Finaece Divislon

SUBFCT MKULTRA, Subproject G1

Undar the authorlty graated In the memorandur. dated 13 Aprit 1053 froro the DCI to the DD/A, and the exteusioa or this authorlty in 6ubsequent tacmocanda, Subproiect 81 bas been approved and \$58, 812.00 of the over-all MKULTRA project funds has been obllgated to cover the subproject's expenses. This obllgation of funds should be charged 1o Allotment 6-2502-10-C01.

APPROVED FOR OBLIGATION OF FUNDS:

riginal signed by

JUN

I CERTIFY THAT FUNDS ARE AVAILABLE:OMLIGATION REFERENCE NO. 25 26.JUNCHARGE TO ALIOTMENT NO. -2502°10.001

Date: 251856

Distributlon:.

Orig-å 2 - Addressce 1-TSS/OC1-TSS/FASB 1-TSS/SRB 2-TSS/CD

TSS/CD22 Jun 56) A

61-56

22 Juno 1956

AUTHORIZING OFFICER

[PAGE 80]
Crigiast 25Jone566/5/56-57 250210-001\$58612.00

9-2572-10-001-22.891.04
35.567.96
5815.9.06
9-1503-7590220,198.20
0535.1009.491238.360.80

1615619537.003907500
24n5739.07500 7 0d 5.7 50000.00
328cecl57 5t,av.nd
42.lct5858.4590
5.11.0ug5958,459.00 618160 60,797.36

61-57