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Thanks for your letter of 26 November 1958. I do not yet know the January schedule, but I am anticipating that the Committee on Drug Addiction and Narcotics will hold its annual meeting in Washington sometime during that month. Dr. Eddy is coming down next week and i.may learn at that time when the meeting is to be. I will let you know.

I have received so0 mg of Psilocybin.) 1f you would like some of the material please-letme-know. I have now given doses of 2 to 3 mo/70 kg to8 men, and am observing definite effects with even these doses, which are lower than those recommended by the company. The pattern seems to be very LSD-like.

Concerning the benzimidazoles, I am enclosing a thermofax ccpy of part of a letter from Dr. Eddy. The three compounds mentioned are not these of Janssen, but are produced by the Ciba Company. Two of them, you will notice, are tremendously potent in monkeys (see figures on' physical dependence). I could probably obtain small supplies of the two most potent drugs, and will ask Dr. Eddy to obtain some for me when he is here next week. I also have a supply of Ba-l9390, and some information about its use in clinical trials, It is not as potent as morphine in man and, therefore, is of little interest at the moment.

As soon as 1 talk to Dr. Eddy I will let you know about the January dates.

With kindest personal regards,

Yours very sincerely,

Herri Hcel Harris Isbell, M.D.
Director

HI:tich

Enclosure

C-23

B-89

147

一

DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE

Matee Ipattate of Meaa H Addktias Reseucà Ctater U.S. Pabke Heslth Survice Haapital Laxiagte, Kastucky

PUBLIC HEALTH SERVICE 1 December 1958