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SG RVL in 及 cmn

The informatlonon F-230 which you sent on January 25th is most helpful. Do you have any information about supplies of this compound?

Since our dogs run between 7 and 20 kitograms and since the dose in dogs seems to be in the order of l00 mg./kg. we would be using approximately an average of 1 gram per trial, we could, therefore, test about 10 dogs. This number might be insufficient. i woulć like to obtain more of the compound. Meanwhile we will begin some very simple preliminary work with the amount on hand.

I am getting into about the same situation with BOL. Preliminary work with this compound indicated that mild LSD-like efrects began to appear in human subjects with total doses of about 4 mg.I have written the Sandoz Co asking if they could supply more of this compound, and am withholding attempts at blocking the LSD-reaction with BOL untiI I hear from them.

Results with the second batch of Olioliqui seeds were identical with the results obtained with the first lot. With doses ranging up to 5 grams total there was no evidence of any psychosomimetic activity.

Doctor Wikler will be in Washington from February Lth to the. 8th. He is on a promotion board and could probably be located at the PHS headquarters, if you desire to see him for any reason.

Very sincerely yours,

1

Harris Isbel1, M.D. Director

A-266

Depa

IN REPLYING AGORTII THENAOAL ISTU O MHTAL ALTH·AODICTION REIIAACN CENTERU.S. POSUIGHEALTH SERYICE HOSPITAL.0. 80x 2090L. ER

F HEALTH, EDUCATION, AND ELFARL Put Health Service NATIONAL INSTITUTES OF HEALTH 31 January 1957

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