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SURJECT: JFile Review

J. The undersigned has reviewed three folders labeled These folders contain reports and miscellaneous correspondence pertaining to a classified contract betveen the Agency end the National Institute of Mental Health, U.S. Public Health Service. Under this contract the NIlH conducted tests of various hallucinogenic drugs including LSD. The stated purpose of the experiments was "to find synthetic analgesic and antitussive drugs which are as safe or safer than codeine." The file indicates this work was initiated by the Department of Defense prior to 1951 and continued under Agency sponsorship from 1951-52 through 1962. Fumds were initially transferred through the Office of Naval Research and presumably this mechanism was used throughout the contracting pericd. Funds involved varied betveen

2. Actual testing of the drugs was perfored by NTM personnel at the National Institute of Mental Health, Addiction Research Center, Lexington, Kentucky. According to documents in the file, testing was accoplished on animals and human volunteers. The file indicates that the huan volunteers were patients at the facility in Lexington. The Agency project renewal states that the tests "are accepted as standards for legal action by the Committee on Drug Addiction and Narcotics, National Research Coucil". There is no indication in the files that testing was done on unwitting humans.

3. The file does not indicate what use the Agency made of the results of the project. A report entitled "Final Progress REport" is contained in file folder #3. This report sumarizes the results of the project through 1962 and states that the project will continue with NIH financing. The report states that the goals of the project were realized. Among-the results were the discovery of two useful analgesics (Darvon and Versidyme) and an antitussive (Romilar) as well as a number of other drugs which zay offer a substitute for codeine.

31 July 1975

MEMORANDUM FOR THE RECORD