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Deputy Socurity Officer, CIA.

ARTICHOKE.

1. :It io requosted that ,thie ledical Staff conduct thie neccssary rescarch to dotemina.thcther the hpoopray has ay practical application in the ARTICHOKE Progran.

2. It is furthor roquested that your staff procure typos of arpoules required for uce in tho hopospray and preparo experimontal donages in thieí of tho following druga no usod in ARTIClonE oporations, as vell as: such. drugs considered practicablo from your standpoint:

Sodium Atal
Sodiun Pontothal
Deooxn and Related Compounds
Scopalorine

3. Theso dosageo to be adainistered exporimentally to detomine efriciency of such drugs whon adainistered by hypospray as moasurd .against like dcsages adbinistorod intra-venously, or intra-muscularly by hypodermic ncedle.

h. In rescarch conductediby your staff it is rcquosted that itiencompass the dovelopmont of the hypcspray and eccorpaning apculeo .to enablo surrcptiticus use on individuals not under our control with. aviem.to .bringingthon undor control.

Soo attached appondices'for inforation concorning tho hpospray contatnod in Iaso filos,. uxi also for certain quostion proposed by, Tochnical Resoarch Staff..

A18+,13/7

21 Novem.

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. The Technloal Rescarch Staff considero tho Iypospray, under cortuin conditions,. would be o uxtreme valuc in fiold operations. There arc, homever,, may questions that have arison and nar are listed Lelow:

A.It is belioved that the atandard corrorcial llypospray cischnrges a lcc. anpoule.. Is this thc only cize mede cr developod comorcially? lould a 2co. or a 3ec. liypospray, if workabla and clinically sound, bo of reater, value and uoe than a lco.instruent?

B. Verylittle is kmorn about tho various types of apoules used in the llypospray cither conserciallyor experimentally. Wihat information isavailable in thiio connecticn?:

C..Furtiermore, it vould te:afintorest to lmor what conccntration of liquids 'and solids'and what types'of.liquids and sclids have been used in tho liypospray apoules and with what results.

D. Sinos, as far as it is knowm, the Bypospray can only bo used intiamscularly or into the fatty.tissues of the tody und not intravemtaly, what dugs or chomicals could be used in a hopospray instrurant that vould:

Produce a cam: (with particular erphasts on speed).

2. Praluce fors -of.muscular failure, posuiblyaong Linos of. curaro roactions.

Produce lethargs, disorientation, cuphoria, intoxicution, dte.

E.This Staff has examined tho standard comrorulal Hypospray.
In its present for (and alsoin the pistol-grip tyte as used at Valter
Fced and-elsowhere), it is hoavy,clursy and incapable of sirple conceal
mnt. las the Hypospray been madein any other fom, shaps, sizo or
woight; for example, a pocket-typo modol resembling a fowntain pen, would
be of matorial advantage.. Haa an instrunent been huilt having a double.
barrel; capable al firing tro mpoules pimultannously? nrav cnn be usud

F. Ne should like to loot whetier ornot tho liypospray can be usod throuch nomal cloting, ireluding poscibility of infoction anki whothor or nota special lypocpray could bú devoloped that couldbo effectively dis charged trough,normalclothing.

APPENDIX II

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0. ac chould liko: to know thethor the Hodical Division, could intervienand/or theechrician to examine cxperirental nedals, of tho lhypospray instrurent thich cortainly must have.rgon developed in connoction with work on the liypoupray. Sone of these models, whils not being comrercially practical might be extremely useful from our, point of:view if properly nodified or covcloped.