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MEMORANDUM FOR: Liaison Officers - Project Artichoke

SUBJECT : Development of a Narcotic Antagonist

l. We have been avised of the development of an antagonist for use in neutralizing over-doses or counter-acting the effect of Morphine, Methodon and most narcotics. The item is known as "N-ALLYL NORMORPHINE" and has been presented by the manufacturer to the Food and Drug Administration for approval.

2. This drug was developed because of the recent fatalities in drug experimentation in the middle west. It will not be offered for general distribution but will be stocked in major hospitals and research establishments having a need for a morphine antagonist.

3. The drug is still in the "irade Secret" class and this information should therefore te used with discretion. However, the manufacturèr has assured us that he will provide CIA with further information on the drug or samples of the drug itself if we have an interest in it.

H15,2 , 64, 15

19 December 1951