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Dcar Dr.

Thank you for forwarding tho two prellninary copies of your proposal to e for review. I have taken the libcrty of dietributing copics to many of the intarcsted pereons for information and corment. I will keep you informed of ali reactions as I recelve then. In che peantine, I have completed xy review and would like to take this opportumity to thank you for the effort you have expcuded in preparing this proposal.

In the course of our 18 May telephone conversation, I revieved many of the points I would normally have covered in this letter. In the Lnterest of brevity I will sloply outline thens below.

i. The macroclectrode-micro-manipulator coutradictioa, a isprint as you explained, however, nore information is needcd as to dcsiga, placoment, etc.

2. Sinco the dog skull is sonevnat varLable, what crlteria for stimulating electrode placement will be used? Will you be uslng a standard refcrence current to eliminate variations due to positlon? If you feel it necosoary it way be wise to discuss the problem.

3. The problems posed by possible contraction of the spleen.

4. Organized criterla of effect, L.e., behevioral, analgesic, anesthetic, etc.

5. Use of doscriptors and measurementa of wavefors, l.e., rise tine, peak duration, decsy cime, etc.

Regardins thoee problens the tost scvere test vill be to organizo suicable scaio fpr judging the effect of electrlcal sticulation. This scction in partlcular peeds expunsion and refincecnt. Do nor hcsitato to use references to ostablish prcccdent. It cacms to mc that sope care vill have to be exorcised in the organieation of thcse criteria to prevent the final sussary fron degencracing into an anccdotal summary of a ceries of case histories.

C00021811

May 25, 1966

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Since the mode of applicatlon of current through the elcctrddes effects the state of the animal, I wondcr if you intcud to etandardize the procedure of turnina-on the current. What will dotermdne the maximm current strength to be used? What consideratlono will detcroinc how faet you will approach this raximum? If you proceed through a range of inteneitles, to a fised maximu, will you be preparcd to record transient changes which may occur?

Ao I underatand your situatios, it will take twe ponthe to get the ppogra undervay. Onco started you plan to uac So0 doga in the courae of che pext ten montho. I belicve you also plan to re-use ticae entails thcpever possible, within the conctraiats Lposee by thur potenisi residee. effrcts of prlor manipulation. Consoquentiy. I hae no. doui. la: yo vi!be able to complete your study as outlined in the first year. an: have boon joined by others in wondoring about the dctoils of your protocoi. Pethape thess questione may be answored best by further discucslon in the bouy ef the proposal.

I have finished with my specific coments; hovevcr, I vould like to address a few words .to the general problom of getting eicctronercosis research aponsored. Because of tha rccent bistory of thls field of endoavor, spotty-ncso of performance and redundancy of ths work it will be difflcule. at best,to sell. Consequently, propocals in chis subject area will have to be complete, well documented and realistic in scope to receive support. As I told you last Octobcr and reiterated on the telephone, X bellevé this study is both needed and wanted. But to recelve any but cursory attencion It will bave to deal with well-orgmmized, hard-headed research. Eves then, it would bo foolish to ptomlae support of any kind in advance.

Wich this Ln mind, I would llke to aok you to aake this proposal as a atarting point, detall out your research plan, and place it within a documentcd framevork.

In the meentime, if you have any noed to call pe please feel free to do so. I may be reached durlng the day at Area Code and will be happy to give you any aselotance you may require.

Rcgarding your question on institutional overhead, I can scarccly be concldered an authority in this area. However, Lrsofar ae I cen determine, this figure Ls negotlable and will not have any efioct oa the acceptability of the propogal.

Once again, I wiah to thank you for your effort Ln preparing this proposal.
I am looking forward to a continuation of pur comication.

Sincerely,

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