88-C00151514

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(b)(3)

I am enclosing copy of the Annual Progress Report to the \_Office of Naval Reseorch. There is no materlal In this report which was not covered in the Annual Report to the.Public Health Service, copy of which you already have received.

Since I have Last wrltten you we have completed a large nomber of experiments with LAE-32, with very disappointing results. We have sezn no evidence of effzcts of any kind with doses as high as l25o micrograms. This compound seems so far infzrior to LSD-25 that work with 1t has bzen discontinued.

We have been busy obfeining control determinations (fasting) on the rate of disappearance af blood alcohol, uslng both the breathmeter and direct blood determinations. The effects of three typęs of food -- steak, bread and cream -- will be begun later this month. The necessary preliminary human pharmacoiogical Investlgations are underway with the metabollc blocker, beta-diethylaminoethylpropylacetate, and with chlorpromozinz. A vartety of experinents are being planned with both agents, once the necessary background informatlon has been obtainzd.

I will be in Washington on Wednesday, janusry Zist en route to the meeting of the Drug Addlction Committee in Rahway, N.J. I would like to spend the morning wifh you and Mr. Bortner, If that Is convenient. Piease let me know.

Very sincerely yours,

2 Harris Isbell, M.D. Director of Research

DEFAFTMENT OF EALTH. EDUCATION.ANDEFA

C00151514

LEX KY 477

PUBLIC HEALTH SERVICE LEXINGTON. KENTUCKY

DR 5 PUBLIC HEALTH SERVICE HOSPITAL NiMH Addiction Research Center

5 January 1954

Hl:rn Enclosure