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PEOPAIICUM FOR THE RECORD SUSJECT:" Trip Report/Edgcwood Arsenal

. 1. On 6 Februery 1975 we visited Edgevood Arsenal Kescarch Leboratories (EaRl) Tor the purpose of clurifying ti:c nature end cxtent of work conducted by Edgewood for the Agency under Project AD2l. Task 03 (U.S. Aray designator). Certain details of this work are pot vell Gocu axentzd 1n existing Agency files, and all personnel directly Imvolved with the research have subsequently left the Agency, The research in questien, a part of project OfTEn, was carriec out bctreen February 1s7) and January 1973. Agency records indicate that EARL was requested to cease work on this project cn 4 January 1973 and that charges cezsed to be seds against the contráct after the January-Apr1l quarter in 1973. Although S37,C00 was originally allocated, the program had expended \$27.352 at the tine of teraination. 二

2. We ret in Dr. oüfice, with er., Dr. and tr. all of Edgewcod. The gist of our discussicn is es. follows. Previous work at Edgewood (not sponsored by the Aoency) had invoivod acministration of a substance kncin as Easl57 to militery end prisoner volunteer subjects. In these studies,administration of Ea3l57 had resulted 1n deliriu and other psychotic behavior lzsting e or four days with subsequent cnnesia. There rere residual effects lesting up to six weeks. Dr. as positive that no work on hurzn subjects tes periformed under the contrect with the Agency. He indicated that ultietely testiag on huan subjects would have been a natural conclusion of this ressarch. However. the project was terminated prior to the establishcent of the necessary prerequisite analytical and aninal expsricentation.

3. The purpose of the Agency-funded research kas to investigate the potential 1of.EA3167 Ifroe both applications and threat assessment standpoints, since it kos knchn that the Soviets were actively working with siailar compounds. Three tasks were conducted for the Agency concerning: -.

a. Development of analytic methods for detecting low concentretions of EA3167.

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b. Estimation of the fraction of Ef3167 trelsferred froa various of the cherical to rabsit-

TEA3167.

.4. Developent of a satisfactory analytic technique for EA3167 wes never achieved. The coapound does not present sny unique structural coiety which would allow its Idcntification chemically. particularly in the presence of tarbiturates..

5.. The second task was epproached ties of EA3167

Sioiler quanti-

6. Because of the inebility to develop satisfactory chenical analytie techniques, an azount of /EA3157 tas synthosized. This wes to have been used in subsequent research, but with the terairation of the Ageney-funded work In January 1973. the EA3167 was never used. We were told trat most, if not all, of the substance Is still on hand at Edgenood.

7. We also discussed the sparse docuentation of Lhis project." Te Edgewood personnel indicated that the work was rather closely guarded at the tine and cost results hed teen conveyed verbally. The few reports received by the Agency had been handcarried by Agency personnel. The pre meture teraination of the project also meant that the usual final report end relatad cocumentation were never prepared.. Cr cid not exzctly resenber the reason for additional charges to the contrect during the first quarter of 1973 but thought that late billings for prcvious, onclassified work Cone at sther EARL labs was probably the explenotion.

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