MORI 190866

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appeared to have an unusual degree of knowledge and interest in chemistry, for a psychiatrist. His main intorests in the gen'l field under discussion are inhibitors of glucose combustion  acctyl choline estcrase inhibitors.

said that thiaminase had been suggested as a glucose combustion inhibitor. (Review: Yudkim, Physiol. Rev., 29, 389 (1949) ). However, it is improbahle that thiaminaso could he developed into a good covert weapon. Since it is anrotein it is ineffective if given by mouth; it must be injected or inhaled. efelt that the amt. required to effcct a psrson with adequate dict would bo rather large for optinum value as a covert weapon. Anti-thiamin compounds were discussed, but they io not seem too promising as covert weapons because of the comparative large ants. thich :rould probably he rcquired to produce a noticcable effect on an individual with an adequate dict.

mentioned radioactive ascorbic acid. It may bd effectively givén by mouth, injection, or inhaled, and it tends to bo concentrated in glandular tissuc. indicated that a very small amt. of the material would produce destruction of the adrenal cortox. Even a slight damage to the adrenal cortex would produce symptoms charactcristic of Addisons disease-- disturbances in sodium and potassium metabolism and in glucose metabolism. Severe Addisons disease, if not properly treated, will result in death.

ave thc names of.séveral individuals who are active in this general field:

felt that sedatives such as barbiturates are ahont as good as anything he knovs as interrogation aids. lle thought alcohol was aboutas good. lle felt choline esterase inhibitors should he invest. as. antipolygraph aids.

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He said various shock trcatments are effective in producing amnesia. Insulin shock is not effective. lletrozol shock is effoctive, hut it is a sloppy method when usod in actual practice. lle thought several repeated electroshock treatments givon in one day most satisfactory proccdure. He said the Japanesc used ordinary ll0 volt alternating current in psychiatrie. practice during the war with aoparently satisfactory rosults. lle said alternating current produces more confusion than does rectified alternating current, and a square wave rectified current produces the least, confusion. There is a discussion of this in a recent issue of' the Bulletin of Math. Biophysics.
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Polysaccharide or protcin, trade name, "Pyromen". A dose of 1 or 2m, gives a fever of less than a degree, but a ten-fold-incroase in dose would produce a definite clevation in body temperature. Althoughthe chemical nature of this material would indicate it would notbe effective\_if given orally, it should be cffective as an aerosol.

A 21 reb 52,

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