MORI 149502

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XXCUN FORI TE EOD

1. Obser sover of being a congaltat to visits vere made to TUKWIE 2 An 99 nd

12  193.

2. (crade curare, a cried extract of cerain South Asrioas plants, bas boo weod as an ao poison by south Aaersan patires for yer.).

(e puo mtarial prolues panlysis of volumtary mscleo, vhich mkes it o werl ct to stheaio Lnagery.

J. Curere bad rory liitod uetiness in zdioie afare the srea  pure d-tubouaie cplorido bocu te sriablo prcute ocataised iurrities tias mde Lho menlte roa tk we a te ds ritter ltp:bdiotatle. Tne rone of tho anas nor svallatle esarently prxukes essextially prodietable remlts. Amll doece of d-tabocuarise celorida Fotnoes rlaxation of ts cboletal mueeles. Larter costs praoe pnris virn protins aestria or eetics te eatel gate. De ss  ealrsis of the mlee sich cotal wets(esia), e loid ie mly Lstd c  a sluticn; it is ssestive in 12 to 15 ccda is iatectad istrstaly, La 8 to 1s sirates is iatastei intrmmsalarly.  Lntrotmed ixto the bty w astder socottre 1s ie aeotie is 3 to j mistos,( mrarias to seasisetica es a esreal:)8t is mt artial

ARTIChake

DRAPT. 87Abrny 1952

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DTEROE PETCMALS POA ETCAL APYLRCATTCES

Dtoooarerie ceride in aqus alution acta roy ragily, but te efsact als deorcasee st a rapid rete. The rapid Lnitial mtia 1s often sosirable for meiisal uoes bus the short poriod of eftectire atirity is oftena rions iiolty.n aréer to ovarce this ciriculty, preperatios of t lkaloid dare ben me by inoorporting it in slov abeorption base cspeble of dalsrering a alinically efrectire doce at s costan rate over  eteed riod of ti. A proas pepered by is incorporeted in a bese consistiog of peanut oll, aycbalertaral deriratires, cnd beesx thie ie soid y Endo wndor the trade nese Tbed.ilr ote e dySg(otcng  d) and bbott (cortaining oil d waz). ais aterial 1o of valus is the troatnt of trmmetio iruries booe s good seal of tbe peln and dissbility in m caoes re  to aclo opan. io can be coutrollod orer lons periods (1e to sh bours vith one injection) vitbout the es of parootice. The disadvantaso of those preparatiocs io tiict thcy mut bo vard beroe so to obtain a booeneous reperetion and it st be haled by yerson orioccd in girins injotioe.

a. Long-octine Cunre Proparrion Tor Solf-olninistration

A lon-octing curaro piuparetion which coud bo rtulily pelr-oiminiotered (aiaptaule to ue in roen, for inutaoce) or niminicterod by trcined cr untraiuci inivisualo wnld be of great value in the Lmdiote rulio. c. xin and dioability arioirg Ira injrios to trooo or civilinno durine var-tizo couditions. Iu mey ecses a dicabled peruu cuul: lu returied to imediato'cfrcctivaneos, in othera the cxtont ur Liankility coull be materially renuacd.

recis his cxporloie nni fecliitieo woll pualify his to doreiop a curare trcpnratics au'nuie Por thia yu-xeso; he Teola-he cn prm or lopnse tho fecoihility of hio luens vithin abcat four moaths. Bo vould liko to olitain a mocarch ecrtrect to Abvelop a prennration vith thcoe opucificationo: (1)) Has an imdiate curare orrcct; (2) Eas a proloned cure orrect; (3) Can be uod in n tya cuient; (i.) Dos nos rouiro prolininaybanting or other proparntioa; (5) Produccs stcndari prediotablo roults. Be vants to prouce averal praits, woins difsrens (cur:a-tet) ccapounis and vrious fonulatians ani subjoct tix to prclinery aniel eericntation. e can ango cr urther imi oxperiontatio nd clinical tegt  ty c be d eo to doai.

b. Curors Properation for Pold Bcrvo Gas Proto:tioa

balleros bo can protec a cuaro fotulation ytied would be impodiate-actina, can besel-naiairtored tor Lnetance, anpens), mdmich rill be tar noorior to Borre Das Field Protection. pow arailable. This vould be a dirroront protucs

[PAGE 3]
fr (n) or, d bo be tried s Lies rith aati -craries. B voé lie to Bare a resarch oootrat to derelop his idoas. Booss so ae the frlatios ii cnical testins wldbeto

(1)  ab 1s vere oared ritbut bei3 alloited or propted by m. I rs earerul totry to neitbor roriy po dony ano jdeas be bod vaiad touched on olassiriel Lotereote) no clasified inrantion ws koringly voluntoerei byno to

(2) a t \$20,000to \$25,000 stiato bo e to ror a reoóarod projeot raferrod to a and b, above. hn t v gir  tho ap of the t i doa not ropreseut  considerod eotimto. I? tho exprs00s an iotorest, bo vill mubit a nore cansidorcd ootiuate cnxd brcek tbo figures dora to iolivlaual itonp.

(3) Ls he gets a contraat rrom he intonda to outain the sorvlens of (letor bo uuii vill probnily teccn asouciated vith ia stete ho ge a cuatrlct or m)

(4) sentimei Whoe nen an lning acquainted vith his work atl tho gemrel field:

5. IOIO OH JOLRI UCR

T iolluin iirnvort uncor cutr vocutaiu durine tho discussicne vini

a. Partially pirirlodl cumm is u nucesanlly by Snth Ariean nati to kil eon ul ononics. T aoril in put on tbe tip or apoors or blos dnrtu ai It friucus en clicat imxdiate paraiyais of the viciz. dsacrihed rutire rothodo ad rosults anvi oheved opoclsens of tho ogtipront

b. concarning posaibio Hilitary uaos ror curo alkaloiis. at thot timp thore v imteraat toamuo the Qenrns oeeoi to be quite iotenested in crude curare. It vao fand thst very finoly diriaed cnrio curcre (preserabir of the otryclinoa tpe) plus a nezal rritnit d a alnoot inoliote pelyzis eriect vhen nlosoai a perosol or povder. e felt tie a ileuity vitb cuare.

[PAGE 4]
5 lor lttey  e rityos t materiel (this would b mo éisetrmstage for crert soe). There aro say vatar ociubie curae, ad the mesal Lritant croly Lresd the reto of sbecrgtion afee sode materiel.

o. e itmtion s ragiy abgd nce 1l, so tat no far more potsataets s btecrtainod fraa eruée crae.The cnude material coutaiss tcxirareno capounds ror silitary torert) use vould be oaparatiraly dirriols becanse or the tinesnd work 1t vold te to etros, Ldentina, d tost iodiriciel teirane .

a. Pertielly purricd cre duraro vols de eay to oten bave poseibilities for ilitary (dorert) uess. It is pore potent than pue d-tubocurarine chlorice It bas bots the d-tubocurarine ahlaride properties and vhat are jounlly conaiiered udesirablo side aftoots ror cuare used in podicihe. Treso additional crects lovoire hiataine-like reactiono Tis material plue a naoal ititaas abould bare en Lmodiate povernulemect in mell mounta, ben rolcasel ao nn aoroool or pvdor! It wuld to vory cfrootire 1f Lntrtluod vitbin the Ixdy by a dart, ete. It bes little or no esroct 1 it gete Lato a ull pronk in the skin or  takan orally.

uppurently tu prianrily intorouted in the deronsive 0. uo of ourar, but h anid bo kould vury villinely cocporate ia ary vay he could in anythlik; involvine tiw defenwiw or ofreasive un o. cuturo alkloiio.

5. ACTICH:

a. Pas the Laromitiod in paragraph 3 along to for whatoor cction they Toul deuirtble.

ad b. Obtain a TCP (Ec mmrits cloaruwo for pursuo the potentinl corort uoa of cuuro alkaloids nurtber.

Basoareh Devolopn

Original a 2 oopies only.

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1. an this day, the vriter coptagtod

contact vas made through 00101d station. aocredited me to as a CIA representatire and thon left and tho vriter elone.

the constrictor substaoce, banzodrine, and other sixiler drugs.

3. contrel rerous suotem dopreuaants nn' a!'unts, both in their peripberal and contrnl maniroutationo. to coniurtivo ronearch vhore facilitico and composcnce coula bo erroctive. of wy Ds suuutanics or olber mattors of interast to us in tho goneral fiold of chnmical nateriuls that aight bo or uuo to us.

4. 1t 18 tho vriter's roelin: what amall, very scpsitive problcns could te very socurely cerriod out

5. The follovins vpocilic facts were brought out in our discussion:

a. Indola annloguo of benzu ine - mentionod a
vo:y intoregtins substance vhich thay ran across in thoir
benzedrine.researobes. It is the indole analogu of benzodrioe. CH,

[PAGE 6]
When giren at s doeage of 50 g orally this compound gires the rubject a proround depressioa - juat the opposite ofeupbora. n upparently gires a deep-eeated depression of the central derrous syotes vaich extends Lato the motal pbere of mood and alertusss. They idn't look Loto this ay rurtber boceuse it produced this very undesirable reaction. thinks that macy indole dariratiree should be stadied ror this type of atirity.

b. La0 - Te discusalon toucbed pn LsD oaly insorar as inquired as to vbether anyoe vas Loukin, into iniole deriratives as struetural maiogues of LaD. Bo thouht this field ahould be studied Latenaiveiy in order to Sini ccaporuds much sixpler than LsD in structure that bave the soe kind of setivity. o suuçested that re rind out vhat, has done in indole conpouds.

c. liethylene droxy benzodrine - bas nnavored the Tact that tho methylene droxy analonw or benzodrine produoes ballucipstions nental Lmages and mnntal contuslon in dooes or l00 g taken orally. Their studlou un viaual imngery anl kneo-jerk reflox lidicate prorbuni CHs elrect ror this type of corpound.

d. quaterary Salis - They discovored tint tho bexndocyl tributylamuni iai ba vory high toxulty ndiinistered iotrnvouounly in gava quutities.

e. Caponicon iu Funitian ith rosearches "derturins tenzeririn inhnles", rownd thut capauicen, the metive prinelpls ul' r! pepper. al sn eiopler ryathetic analogues vere very erertim 1.n pralucing a haraloss burning aanaation'on contaat.in cxtruwoly lov ccncoutrstioms.

r. Murijuana - iniluatod that a more or less conprebensive piece of reorirch hod teen dono during the laut War at tho undor the efricicy of xarijuanc for eleciting informtlon. didn't kor ay of the dotaila.

g. indicatod that the peroon in this country that bo thinks is nost highly qumliried in the fiald of piuarmcopacholagy alons the lines in vuich ve are Loterstod 18

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1.Tis da the vriter briened on cortain
reeearch irterests and peeds of d. A detallod tour of the
Fvus also mde lator in the dar. E, uide froa
the potential involvod in his ow sclontiric aouon and in tbore of bis is obviously in itimato touch vith prctically .

all the chezicel and pliarncentical mcnusacturors on the makes tripe to waabineton frequontly and hna agrued to call the vriter hon be is in tovn. 41-1

2.The contoot vith wmodethruch of the  Mieil statlon vho intruced tha. writer as a CI reprodentntivo nd then lort.

3. baro a toohnieel starr of about profcosional chaniets, biochenisto axd enpincers, niri are currontly netivoly engagel in reoearor in tho tolloving flollsi

b. me phrpical racilities or the laboratory sees to be adoquate to do efroctive vork in these fields and the porsonal thnt, the writer contocted seoed vell trained and eotbpiaatio.

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J 1. Dier cover of being a copmultant to vas coutacted to disouss the technical nepocts of the prorod to be an excoodingly dogloeer problc.Ingeneral caupeteot pcientist, combining a brilliant, incosivo intellect vith versatileinterest in all phases ofhuman poychology. versatile interest aisqualiried bimoel? and bis dopertment fro any nnd his dopertmont from any nnt.

work on sonoory percoption in dors, pointing out that they had not s great deal of opecific uxperionce vith dogs as subjocto, nor didthoy bare peoplo strong in the chicaical and gaagetoering" disciplinos neccssnry for this kind of work.A dotailoi diccuosion of tho dog folt vory otrongly that the besio part problca indicatod that tho merenrekithould bo handled ry a resonrch puychologiit, strong in coparative auianl poychology ani vith a gool baaksround in tho dieciplines mentioned aiuve.: e mugcsted the folloving as som likely caniidates:

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Britisa work in this fials. The writer orinoed no intoreot in this, bust is was obviome thae ves ritally Lnterestod in this ebject, and dis diaesion of the sbjess rerecled the rollovine poiatas

thinke thet Bap Ls woll proven, and thej are etarting worts ta this fiald st miniclty is in proridins bot" sabjests. Sone bave bees acorored yet

. De Britiat vork Ls mah better tan De Dube work to date.
It is more imaginative and the exerineuta are much better laid put.

himselr ie too vrapped u in tryins to prore theologioal point to be a eapletaly erreotive ecerinanter. Lark eoerimeutal vark oan bo done in thie rield.

h.ve si, inicatei a villinoss tn fill out  o. ho viter tin vouid io as exsellcnt adiaition to la's group af conmultarts, sino ve bave no ops cleared at the conmultant lorel vi 1s thorxihly cocetcnt to discuss. rarinua paycbolngical prowla

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1.  this dete, the iter coatectes a  dess of ointnw. h pupof telt vs to grt critical ppraisal of tbe coutoaplatod reseerch progres o varioe ctcals for vee in covers vetee. 119 ∴ 2.

2. s disoussion of the prodsotion of rotroçrado mesias by chemicel moans, elt at oono Length on two pysicak tocbniquos vhiah be bad previoualy iscussod vith

a. Meotrorbock- boliores thut clootrbock, repeatod
three or four times in tbe spaco of one bour, ahould produco a high
dekrue of rotrograde amesia. Be said it would bo almost inpocoible
for them totest this cxxrinentrlly et beco of the
sevority of, tbe treatuont to.the pationt. L

b. "Ioepick Oxration" Uut eloatr&hock iu prohiue abustheaia, a Waabington sureon bro rury tizoo muccosarully purforned nn oporction inrolvins piereirs the urain uat cvor the cye sith a fino surgical "iccpick" end dootroyin?, cortrin fruntal bruin tissue, with pervous coufusionel and ncsiserrects. Thia oerution loaves no marks on t snin.

3. T posaibilition of usint (t)2, privin, trnzole, hi tennioas, anii-vitamins, Be, an lsD was discusiel vith thought thuy all ofrerod soxo prumiso, but vould plnco high O teneicns and aoti-ritaxins at tho botta or the list.. Be thought that roeomrah to asper our speciric queutions on each of these subotances wue peeded, perticularly in tbe case of Lad. Bo vas sked ir any of the work be vas arsre of could ansver our noels. Eis opluion voe that experinontal work spacinically desiged to our oporstional poeds vould proride tbe ansvrs.

4. mntioed the Erpoprey ector end r pleeod to boar that ve were working o it. Bo gave the vriter soe intoregting literaturo an pesia.

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MEORDOX POS:EEXED

SUBJICT: Ctig

Contagt vits

31. odor oover ins lts to the rieitwsnde to the boepital ror abous a year boring last boon autbur of the togortant tert recantly publlabed

of the has boens reooarch direotor of

3. To cumont rosecich eifirt at 1s bin ritos elans the follovingthree Line, vith uy proapests ia tho plannins rtacer

BxC

S. Rich Ocmen Tensions.

a rneaich pivposal antalling to aaty the

enect a ist o tensio in ponl a pebotic patie. allrecearah st ,panmel otcearallabiofrau rolu.sers ad the hcepital rtet).  the ocnteut of agon in a properatoryrs sixte is raiaod froa thoe noncl 20% to 50p, montel connisional eprcote bocae aprerent in both nonmal and parchotio patiants. The Latereot in this aris from te Pnct thet practioally all a tbe elderly poobotie patienta bave oerobral artarial sclerocis, shich means that the braia is not settios encucs wop. s is  raletivly uchersed fiold, vith abriose inplioation

DRUPT. F 6 Pabruery 1952

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.     t s
Siutanie atld acte as a sos cstimocs stiilans to te aéroal
metulla, wics peéase a ecasisat alichs anosa ef airesolia ia the is istarestpi ia a very ecsprehancive
expertas e pia sees the partare of thia efteot ia Borasl and

d. Msronim Poweftrtes - Mrgde, wisa ite efrert ca acotyl chaliss eeveass La a crosd istesces ia csral ron  mtel diocase. Aeetyl eolise ia te medisdor for the nervoee syatam and in his vers ca G-eeeoe, tor cevelopias strepina se tho oftectire proteatire epans. Ln maatal dissesee like Parkincaa's Piosese acd epilopey, strcpize lito ecspon wita a sinal prighesal afeet and maai cootral aoas e mocdod. Estsene recssraae ie baias modertatem at the Boapitl so mcover soss capoanis.

B. Vitapis B Deticioncica - Binoetho braia css ue only carbchyirate lor enorgy, and since the metabolion of Ees's cole, B cerioieneies hare fuoctionod brain disturbances. Acute B avitasinoeis sotunlly aauses permanont dogenerative drain demage. This vould meea to open tho possibility of uoing thiadino aatoganists to prouoe oonsionai nd otber mtal states..

b. Listlesunces thinks thot a Jational arproeck to our urgent operetional romircent for a ohendeai prohuciag. a georal liatlesaness anl lothary might de in a. caxpoud vhich proesagoerl aritainoois. ls porntel out that tho nerel Lethargr and look of prodlutironess of the rery lor inooe roape, in the soutbeaotern U. 8. is due to aritamiposis for vitorins Bg, 0md ieotinio oid.

3. indicatad a desire to belp Ln my v possidle, urged se to consult Nurther vith him, and Lndicated his willineas to ll ost  for.  also pid to send  e of s r proposal to the

Obenioal Branch Resoareh à Dovelopsunt

[PAGE 14]
ecatacted  Pebruary l952, as a ccnsultent to Ms iatererts izclude drus adiictica, erus tolersnce, mnalgesia,
anstbesia, reapirstery stsiolo, and ptanoclogothe centrel
riervous system.

2. disoueaod cheaicals mich bare been fod to tenporarily inactirate or permtly destroy spocirio portions of the ncrvous ate. Keto b  is a uch u.  It is od Ln   s tant the troatmcnt of drug addiois. bas foud that if monkys are giren one Lare ob-lotknl inoctioa a keto bomidon (0.18 .g.) they became caletely holpless. Post morton exminatixos the brain abovs that tie vhite matter las boaa dostroyod vhile thero has beon no apparent eroot on the gray master. Merous mnller dooss of the &rus has no murch efract un moxya. said bo has triod this oly on mnkeyo, benco it may be scioe opocirio. Niventil iss related cornound vith erracto vhich mucest a sixilar actions These coapowds are nrinaily Latrducel y inioction, lthouh thuey vould probalybe ofroctire 1inisterl u nn acrosol. 8-emino quinolinos vlldestroy specirie contars of the brain. Bo mucsostod ihrertigatins coapounis vhiah hare boen testod ror anti-onlorial notivity in orier to find moe about compounás vhich efroot opccirio portions of tbe norvoua aysten, Ba meutionad in this cormoction. cou ininsmogh on antimlorielcooua.

3. I monkys are expooed to boavy and repentod doses of etkylans axide thoyloee the nnotion a thair spinal chord, but the ponml nectio returas aiter removal fros the baa. Aocidantal buman poisonincs hare inicateda sinilar eogt rom othylone caice. The ocentratio of cherrical roquired mios it out of the qoestion or oovart motirities, bes th remults ae mastiw.

. sadd thay hare reoently reosired sats moterial cailed ryenotioe ras Merek. B ves pot cartaia about its cherical cpositioa, but isis de rro.s aion plans aad is dood a

[PAGE 15]
ipoectioi or rodantiaio (be v's me vich) in Bogth Aria. I 10 iorogs/g ae ire araly to  dog it podues mar as of. Log duration. Te spaams begin fairly ixmodiataly. This material st the prasent tim. is boing loveotigeted ia

are aleo voriding on sthodols. Sore of those cumpounis produce an extendad (36 to 48-ticurs) los of ocnocioumss 3. and revirsible paralysis. In monkeys thera ie mo apparont ofloct rua the acpounis until a couple of bours ar so arter tbe erug is Rivtn. his group enid thnt or copoumds should be soroened. 0c s. bas rorktod on san of the clinioal aopoots of tio mothoiols, nt oftimothoiola,

but bo bas hnd soe dirfiouities, so it is not curtnin vtuotier be vill coutinue this line of inrostigation. 1010 vas pentionod as anotber poosibility for vurk un mthadola. thet iisto chenicel stulios vould yiald rooults in this riold.

6. In tie field of ahicnls vhich proo montal daruent, bo doubtnl that aytbias vurlld bo round muperior to Lin. Ho cousts thst resoaline vill prure of Lucb valuo. Ih queotiong the mlue os cennibinol cuzouda, int nntiend cuounia, Int nntiad in thio fiell.  snld thrt umuhna intozication is 1 inn intozication1s

probably hn to muncarino, anl that proatiuiia vunuld prvvably give roulto.

wniol if retyl br wniil ro o valu in 7. huorrilla tne varfare. Lo yuiaved cut it io en otorlaoo guu unl 1s quite polant.

w.uld to huay te du wovk fur us in hia apecira 8. Pioldo or interout. In iv inunred nrlully in ainnl wotk rt is not cquippel to symthesiza-ory.'c cionlenio. Binne nothins opocifio villbe at presant has a ooutrnct vith diocusoed in egard to wirk until it cnn bo dotenizoi hat it can be douo rituous rumning tuto copetitiou vith tho

[PAGE 16]
whs costagted cs the oveains of 3 Podrwry 1952.

we asproected under the cover of a consultass to appeered to bo very sourity oousions. E epreseod bis ocntiming coucers sboss seourity and asbad to se the rritere identificstion,

appoared to hare aa umunual dogree or kovlodgo and interest in chemistry, iLn the general field under disgussion uro inbibitors of glucoee combuetion'and acatyl cholina esterase inhibicors.

3. said that thiaxinase bad beaz sucgertod as gluooee oasustion Lobibitor. (aoviovi naria, Prsiol. Bor., 89, 389 (1ghg)). Bovorer it is ioprobable that thiminnse could be dereloped isto a good covert veapon. Bince it is a protein it is ineftoctirs if given w couthj it mst be injeotod or inhaled. falt that the aanzrt regired to efreot  porson vith adoguate diot vould de rethsr lane for optiniss ralue as s covert veapos. Anti taianin opounds vere liscussad, bat thay do pos sos to be too pranisinges corert weag bocause of tbs copanatiroly large counts viich vonld probably be required to proue a poticeebls essect os m Lolirieal vits e aésgrato aios.

6. mentiacod radiosotive ncortia acia." Pis atpoers to hore pocaibilities ns a covert wpa. I sy da eftoctinly gives by zootà, injoctlon, or intaied, ad is tends to be eapoontrsted in glantular tissee, insietet Cas a ry all ans a te

[PAGE 17]
mterial wald prote destruction . tae direnal cortex. Bron a slight daege to the adremal oortes vocld prxmoe sasptoes chareoterirtis of idétens éiosese -iatubece is soiina and potessins sotabolian ad in giuecee mrtaboliam. Sovere seiisoma ciseese, L pot poperiy trected, vill renclt is desth. Sisce Mtiaous disease is not vell waderatood sné radicestire eeoctie seid voulé be ecparetively eesy to issininate, 1s is fals this poessbiisty solé be furtpar Laveotisated.

cave the me of sel iiris sho aa aotive ia this gameral fields ..

7. folt that sedatives such as barbiturates as sbout as good as arthing be koovs as latérrogatioc aido Be thought aloabol vas about s cood.E relt choline osterae inbiuitore ahould be iovestigated as antipolygraph aids.

8.  seid various shxk trontmonts are efoctive in protuaing mesia. Inmllin sbock is not ofrnotive. Hetrosol shook is efroctive, but it is s slopyy metbod vhon used in actunl prectioe. Proper doao, rate of injection, etc. are dirricult to dntermine ror the produetion ofs siven eftoct. Be thought thet rovoral ropeated oleotrio ahuck reatmeata ron io oe der ves the sost actispactory procodure. Dier propor coniitions this vill produce tompurary amesia lasting ror a couple of reks.

Be said tbe Japanosc usod ondinary llio volt altornating current is parohiatrio praotice during the ver vith apperently satisfactory renults. e said alternatins curreut produces prs cemuion tran does reotifiod alsernating curent, and s square vart rootifiod ourrent produes the Lesnt contusio. ere is a diocussion o this in a rooant isse f the Dulletia of Matbeatioal opbraice

9. mentioeed an advertiscnt bo bed pens to about  polyeoccharids or proteis sold mar the tree pas Tac", & dcse of 1 cr 2 ", girs e faver af, less tm a Gagso, bs s taa-old inaroeoe ia doee woaa

[PAGE 19]
2. An extenaire Inspoction of tin laboratory facilities uoder imoliate control iniloated tbe folloving thingsi

b.Rxollont Pacllities oxist for ay type of molical resareb Lovoiring phrsislogically nctive cboical oopomds. Boo subseets vould be araileble for vork thct ovuld be carried out ae logitizote medisal resoarch. Extensiro anisal Sncilities axist for otber kinis of research.

mthodvould o. Cootractual srrangomonts via the indicatod that it rould ba neccssary be very feasible. for oniy one other person to krr vhat be ves doing and bo tharofore nuggested thet be clearei for this sort of vork. Be Lodioetod that vould  bappy to 1ll out E fu. botbdad

d.Current work in e Laboratory is corterel namly aroud sterilisstion. of blood dy abemionl açaats to destroy virus ei spore bcdles.

[PAGE 20]
is is cemetcat aless vontest vith clinisisians,
sopacas, peyatiatrists is dis espedity se to them
nd wil hg  Lat o  mtters La te meieel leld of Later
too: F

b. Boryliuin - Der's  ccaidoable litoratue, mst of 1s stemingTros recent eccidante Luroiring broban leoresoont lightins equipat o the extree toxicity of barylluia. This ia certainly the moat toxio Lnorranio elununc ml it produces a pooullar Pibrotio tuor at tho sita cr Loui cppliaution. The nmnt noosssryto prodnoe thess loal turórc is u fov icrogrs. 513388ts gtudy of the offect of inbaling mull anots of berylluim in the lungs, and othor stuaiies to ovaluate the poteatinlities of borylluix as a corort veapoa.

thoutt bis eould do an erotive jab 0 stuying ari LaD ageats by lxdi one or more objeotie andrans a La0 pplication in Laboratory animals ad sctooning campouods that might ccabet its ectiom. De vas Lovitod by the vritar to corelop this Lnto s resarob propoeel 1f he so desired. Is vs eghaaizoi tant no eoitnt aykd  irlrod in our egteaa reech

5.  rolos etis Loicato y e above usios are a. : Sel   to for himls ad

[PAGE 21]
CTR

1953.  ct

vas eacovtod on 3 Pabriy ws cia vath tto cosigtmm ef and tna misrsigand aiecahci

a rvatatim of . Ts discnseios vich was linited to ths oadjot  carnr liko agonte. • callegs af to Ls Ltoertoi in toxio puaro copodle m etirioial respiratica, ms mot snailloble bocauce af illnsss.

8. Crurio cararo is obtainod by brewiai roote, bark, oto., a cororal Apecies of Bouth Anoricnn plante. It contains povornul alkloida ea is ueod by cortain Bouth Aoricaa tribos a an arros poison. Ao indiriinal or animal strk by such a poissd arrov is rapialy reniered bolplose e to paralsis of the skeletul rixlas. Puriried caro and chcaicals bering a ovraro-lin action aro usol to nnc extent in modiicine, whan it is deoirod to proluce a ralaxation of the skoletal muncles rithout the protution af soostbesia or the proiustion, af central porrous ayates poalysis.

3. said that a Laro mebar of ciuras-line choicaln (mootyl proline blockins, ageots) hare beon propercd and ocroeoed by pharmcettical bousos nuch as Tnrpo and Dcts, Murmuch relccne Co., Ku Lilly, Abbott, eto. A fow subotanocs vhich mot-Nedical roquireoto are nov  to mrt, but bo said g vhich vul o rly t our repiirosauts doro toon disoardod. 2o soid tht if w rrote Goes ths dosirod speciricaticns for a drug vith curore-lirs cotioo, cnd thon caursssod tho aree houass, ro voald mioubtolly find thrt a arus vhicd moets tho speciricstiocs Ls bon scroenod. Tio might te  rothir ontinistic stetoant, but since 8 potant ourar-like scent voald te o value in corert aotiritios, ao afsort siould bo maie to see rnt can bo cbtaird by thie ssthad.

b. lomnl iaostigotos mtiasd vao ars sotio in autreaiaing or testins coppdis of tra caare tyrel. D. Domat, B. J. Pe Boes, J: o. Eo, . R. Lnty, . . . Pato, B. . Crrizgra. o ork of thace and other mod ia dosarited in the book Carare sl Ati curare Acante publiabod by the Dn York Acadeny of Bciance.

1j3, 2, 64,11

82087. 83 Pey 1052

[PAGE 22]
C 5. ezpvonnd ca iutoet in elizioal testing of crare-,

6. 1

a. Cotcia ianortica cbus cursre-like comgocnds auich r been scrconed by pbaroceusioal bomns.

Chezical Branch Reseerah à Dovalogsent

Origi 2 copie .