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proposed work, developmeut of sethode to test bahavioral and other
effecte of drugs La mlnals vith reasonably essured axtsapolation to
suln-till cover & period of telvé moathe at an astimsted cost of Pollovoa vork vill be required for in additignal twenty
four months at an astimated amusl coat of approximately aiter meny years axperience La the Division of
Pharmacology, Fooi and Drug Adminiatrstion,

His umveually thorough and conservative approsch in validating test rasults vas of critical ieportance in our selection of For this project, and argues strongly h fevor occepstul scooopliahmant of the proposed vork. The ppecific taske of chis proposel are to develop profiles of behavioral and toxicological tests of drug effects snd to siteen som thirty to forty Dew drugs of interest annually." Promising drugs selectad by thie mechod vill be furthar tested in bumans in ccoparation vith the Chomical Ressarch end Development Laboratoriae, Edgcvood Arsenal, Edgewood, Haryland. Chemical cocpounds rejocted by the pharmacauticai incustry because of undesirable side effacts are being exam Loed as aandidates for chis test progrem. This work is in mupport of continuing needs for bettor and safer behaviorel control tools and is in support of requiruments concerning chemicel and biological agents affeoting behavior.Tha test facility will be available for test screening ot cheaicels and biological agants submitted by

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