MORI 184588

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LOHALTOY FORI DEFUTT CETE,

Recozendetions for Disposal of Faxins Custody Iype Defoctors

E E (4)looActingChiet, to,dtd T kar loel;Dubj:Dispoati of karima Custoty Typo Defcotorsofall Catogorios, H (0) Consultant, A dtd 20 lar. l95ls Subjt Carents ca bono by LotinA Chial. to deted  5arcn 196l,G H

11 1.. 0 1 y 191, . Pand the undereiped dissussed thess mattars vith C/I

2. The astion called far in Parepreph S of Eofaranos (b) ees rosolved durisc this diacuasior; memely,

a. Chezical nature of the amcsia-inducine drugs Thoy wonld be substituted Theyere nctfeportod in the litareture.

c/

b. Fhysiological efioctat Is arinl studies, it sss found that 15o silligress per killogrea of body weight is fetal 50s 05 the tizo.Iotaldcra to Lsalybout 150 zilligrarsj i.o.s about 70 tires less then the lathal dozags. Borsrer, aa oe occesios, e parsoa aizinistered trice this enount (sodag.) doreloped teporary eesie ant droniness, e oonditio which lasted about 24 hours.

8. Saminotureri is protucing 200gras of the parest substance. MAY 22 1951

1 y 1961.

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Thie mtorial vould serre ar the iacdiute siarting mterial. for oyathstisinc related cozpoumds by alylaties, soubylation, curbonlation, etc.

d. Clicical eridencor Rons mceptins that intiseted in Itez Eb abovo, fros obearvetics os

5. It is the cpirion of tho uéercigood that tile is e uigue epporturity to carry oz & sterile resosrch progre wich is a carble, but a rorth-while one. The physiclegiocl cifocts carsot be triod out en anizcles it can oaly be ourried out rittout crousieg cuspicion by using these ecos wll qualiried to caTycn thit wore

4. It is ertirely possible that this project might feil in providing ay drus shioh could induoe emerie for such long perlods of tire as the l8 nooths roquired in Refcrasse (b)s but it ie also entiraly likely that Crugs may be foumd which will induce emasis for a pariod of soss dayt ar vceks, and as eueh may find uzo for shart-ters disposel of zimn custodr tvee dafectors. C syuthesit would probably bo oarried out at The coeaicel VUH by a chezist alroadysynthesiring eisiler conpouris ier Also, it would seec doeirablo co as to meko two cnrústs availablo for spoeding up the reseurch. horevur, it is not dosiretle to Bnthosise a creat mrber of derivatives, but rather to koop ths pruperation of a fe of these coapounds ir phase with chs olinicel tosts cn thome

5. Recomendationst