MORI 190865

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has devotod most of his life to the study of curare alkaloids. He has spent a numnber of year's in 'hel region of tihere he studied native uses of curare and learned native ncthods of purifying the crude material. In this country he devoloped a method of obtaining, mure d-tubocurarine chloride from the cnude material. He has sot, up the ih order to mfg. d-tubocurarine chloride. lie conirols all steps in the nfr. of the product. Host of his prodict is sold to pharm. housos, and he apparently makes the highest Erade of purifiod curare alkaloid produced in this country.

At tho present tire the company has four full-tine crplovons plus a variable number of part-time stivlent enplovees. The avorage ronthly outout of d-tuhocurarine chloride is 3.5 kilograms.

lescarch proposals for medical applications: 1) Lon-ctine: curare proparation for self-adnin. 2) Curare preperation for field nerve gas protection

Ideas on covert use: a. parhially purified curare is used succcssfully Am nativos to kill cano and eneries. Am naulves o kilu. 7ano ana eneru.es.

b. Very finely divided crude curare (prefernbly of the strychnos tyne) plus a nasal irritant had an almost paralyzing effect uhon roleasod as an anrosol or powder. c. The crude matorial contains toxiferano compounds thich are: extrenely toxic. llowover, developing toxiferone cornonnds for covert use would be corparatively difficult because of the tine anl work it vould take to extract, identify, and test. individual toxiferene cornounds. d. Partiatly purified crude curare vould he casy to obtain  have possibilities for cowr usos. It is nore potent than pure d-tubocurarine chloride. It has teth th: d-tubocurarine ciloride provertios and uhat are usually consideved undosiraris side effects for curare used in medicinc. These additional offects involve histamine-like reactions. This matorial plus a nassl irvitani. shonlà have an immediate poverful effect in snall anounts, vhen roicased as an aerosol or powder. If would he ver ofrociive if introduccd within the body by a dart, ctc. It, has little or no effect if it, gets into a small break in thc skin or if taken orally.