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As direoted, at least l0 professlozal contacts xare zade dorirg tho tine of 18-29 Cotobar l95h. rery dontoct made, by roa good frtuna, through agoncy preparation and mhols-bearted nooparation:of all concerned, had rost sratifying rasulte.  Croiof the tesired subatancse collected han a canzeroial Yalce o ovor é0o dollare,the othar a production.ralua o ovar lcoo dollars.Cthernarerare itess, scnrercially not obtainabls, all, securad vi hoat expanse.to this agency. In additicnvaluabla data and filag wore collgcted, sa vell as specirans'fro cutatading collsetiasfortfirther stoty and:guidancaTheperscnal contact aiths(ield aganta, execntiras: and:seieutists,fold Irienis,and aqunintanees,

recurty. proran.toe Taue of dolitrane, So rasults in over ceacs. He gites dolitroua  dafinite placo intha pey ara or snastneniclo, designati i3a3 asalgesis rathar than asan snaathatio, cd abordar-lina agont,aince it kacpa the patient at lenst partiallr consoions  It nakes the entire oyetaa Anseraibileto pain,incontraot to d localszosthetlo,learing he patient abl to obey instraotiora roa the doetor ard titaiaiag tbo atility to usa te susel bhiia it caasgaLorgetflloosa thobloodalrollation rate is not groatlyigloved, caral swrgory is possibls vith less pieeding and dopreasicn aa well as doep anes thasia ara cly'cbtaired after verylargo doses.politrone has bees nsod sucoeaafally alotsorin ocobination gith otber druga, such as curaro,succinyl chloride,:cccaina,nitrous, oxide and sther(asa detalled data cn,tabla attacsed indental, sye, ear,zoee and throab argorya and in bronchioscops, causi in ccntras to'pantothal no spaana Is daaigivep axtended and prolcreed relisr foa paia in adraced catcar ardii snorrbnidrasoval.iitsuseia ohiicbir isla mogreas.Zor dotailodclinicallreghlty sos Tatle I gttached. Hethods of Acninistration lCralVseltended experixnta ara plamedatercoaplstionin ths labaratorleeof atudies to improva thoiphraicalpropertios ofdolitrosa such as suspension or solution, ranoral arodorrend adsnataoot co the desirable pa

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M azatrasuneuar Injsatioane acuce stinglag paia, lastirg abeut 2 mtas,mey ba avarccns by,the sinaltacacus- orprecediag inactica of a locei mpeathatis, sich ns procaine. The ralsiag or tha ara sbove tho borizontal level in gssa lneoions a zade in, the arn, are alcs recccendel to oreatal pain and tenparary svelling. iIntravénoes Inieotion Teuedoftbe sreatly Lsproved philixed dol peparaim,vhlte, odorlees. powderatayigin 2qcecs solai Sor abons 3a homs,at a pi.of h.5, given interittently. by vein, as aecasaary,is rocon. manded STortunataly this lyophilizod proparation is also how available ior, tho eprdenta rlaned by the sgency,twoughtthe cooperalon or and Ar

Pharaacolosical and Toxicoloelcal Studios
he:vsive af dolone ns, an inravans zoathetia is slao incatod 1 thosoute Lb/s0 sce ths godiua salt or dolitrons, is spprozinatolr 3 timos thavor thiopenta Mile aininal hypnotio doses for theae anesthosles are sizilsr,.the duration of bvprosis is aere than doubled, bains 53 sinutes fot dolitrone and oniy 20 zimuteasthippentalin sinple 601d50 dcare.o cueulaian asobsarvad dth Tepsated Antravanous desing at regular drequont intorvala Aa rabbits, usins dolitrcooy anliin doge this cuaulation wag ainissl. In contrsst, usinghiopenta with an idanlisal procedura,tha duraon of-hypnosia in rabbits ant dogs boccaos Songar withtaseh suceeedins dosai Siges or todeity, as neastrad by henatolety, bexty vishe and. grons and siorosoopic pstholoey, did not oocur in degs shighjvero piatslhed ln.daap.atrzieal aneatheaia Cor.tvo 90-nlmtepariods.Therexas-zo apprsolablsshanza in blcei presaura:in dogs"rsceiving rapsatedirazid intravcnous infeattong ?dolitrote, antil donas yars sivan which re Carse anouzh to cauao car2y218

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absarrod 05381780 and vorry snger detacted. nonkoy9

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