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The materials analysis program is directed toward the development of a systom capable of predicting and iüontifying Bloc Country developments in psychopharcological incapacitating or behavior control agents. The system when completed will consist of a special data base of reference compounds with unique behavioral characteristics, software prograns capable of preaicting structure-behavioral relationships ana.mechanisms for acquiring and testing new compounds of intercst. The system is also to have diagnostic and therapeutic indicator capabilities. A major thrust of the rescarch goal is to develop rapid responsc and countermeasure techniques.

The Panel recognizes the importance of this progran as a means for improving the defensive capability of the Agency. There are some doubts that the collection and identification aspects of the program are a proper function for but the Panel concedcs that thcse efforts are better placed there than elsewhere. Analysis by'of Soviet and Bloc psychcpharmaceutical R, D and T is not being done at this time. Such analysis could clcarly provide

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an input to this program, and the Panel thercfore recommends such studies be started.

There is a scrious split in the Panel over the testing with human subjects of drugs significantly affecting human behavior but rejected for clinical use: some members of the Panel are opposed to human testing of such drugs, with particular concern for political sensitivity and for unpredictable longrange clinical. effects. Others believe that continued human testing is necessary for complete understanding of the potential of these materials and that sufficient controls have been imposed to minimize these risks.

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