MORI 149514

[PAGE 1]
anpeared to have an unusual degree of knowledge and interest in chemistry, for a psychiatrist. His main intcrests in the gen'l field under discussion are inhibitors of glucose combustion  acetyl choline estcrase inhibitors. 1

said that thiaminase had heen suggested as a glucose combustion inhibitor. (Review: Yudkim, Physiol. Rev., 29, 389 (19h9) ). However, it is improbahle that thiaminaso could be developed into a good covert weapon. Since it is anrotein it is ineffective if given by mouth; it must be injected or inhaled. felt that the amt. requirod to effoct a psrson with adequate dict woulu bo rather large for ontinum value as a covert woacon. Anti-thiamin compounds vere discussed, but they tio not seen too promising as covert wearons bccause of the comparative large ants. thich :ould probably he roquired to produce a noticcable effect on an individual with an adequate dict.

mentioned radioactive ascorbic acid. It may hd effectively givén by mouth, injecticn, or inhaled, and it tends to bo concentrated in glandular tissue. indicated that a very small amt. of the material would produce destructión of the adronal cortox. Even a slight damage to the adrenal cortex would produce symptoms charactcristic of Addisons disease-- disturbances in sodium and potassium metabolism and in glucose metabolisn. Severe Addisons disease, if not properly treated, will result in death.

ave the names of.séveral individuais who are active in this general field:

felt that sedatives such as barbiturates are ahout as good as anything he kous as interrogation aids. le thought alcohol was about as good. lle felt choline esterase inhibitors should he invest. as. antipolygraph aids.

[PAGE 2]
lle said various shock trcatments are effective in producing amnesia. Insulin shock is not effective. lletrozol shock is effoctive, but it is a sloppy method when usod in actual practice. lie tiought several repeated clectroshock trcatments civon in one day most satisfactory procedure. lie said the Japanesc used ordinary ll0 volt alternating current in psychiatrie. practice during the war vith avparently satisfactory results. lle said alternating current produces more confusion than does rectified alternating current, and a square wave rectified current produces the least, confusion. There is a discussion of this in a recent issue of' the Bulletin of Math. Diophysics.

Polysaccharide or protcin, trade name, "Pyromen". A dose of i or 2mí, gives a fever of less than a degtec, but a ten-fold incrcase in dose would produce a definite clevation in body temperature.Althoughthe chemical nature of this material would indicate it would notbe effective\_if given orally, it should be cffective as an aerosol.

A 21 reb 52,

ATAKEN FROM 证：

[PAGE 3]
Thas devoted most of his life to the study of curare alkaloids. He has spent a nunber of fears in 'hel rorion of thore he studied native uses of curare and learned native nethods of purifying the crude material. In this country ho devoloped a method of obtaininc pure d-tubocnrarine chloride from the cnuíde materinl. lie has sot up the Fin order to mfa. d-tubocurarine chloride. lie contrnls all steps in the nfg. of the protuct. Host of his prodict is sold to pharn. housos, and he apnarently makes the highest Erade of purifind curar? alkaloid produced in this country.

At the presont tine the comnany has four full-tine cimlevens plus a variahle numer of pert-tine sivlent enplovees. The arerazo ronthly outous of d-tubocurarine chloride is 3.5 kilograms.

Pescarch propesais for nedical annlications: 1) Lon-cctin curare nronaration fer solf-ndnin. 2) Gurare nrenaratton for field nerve fas protection

Ideas on covert vse: a. parbially purified curare is usod successfully byAn nativas to kill cano and eneries.

b. Very finely divided erude curare (preferbly of the stryehnos tpre) plus a nasal irritant had an almost paralving offect uhen roieasod as an anrosol or povder. c. The cride material contains toxiferone compounds uhich ar ex'renoly toxic. liewover. doveloping toxiferone cornouds for corert use would be comparetivelr lirfienlt tecause of the tine and work it wouid takn to extriet identify, and tes'. Iniividual texiferene connoumds. d. Fartiatly ruri ied crude curere vould be casy to obtain  have resetilitiet cor cor ases. It is nore pobent Chan pro d-tul ocurarine chlerite. Tt has oth th d-tubecurarine cileride provortios ani shat are usnaiy cons deved undosirarle side effects for curare used in nedicine. Those addibienal affects involve histanine-like renctions. This natorial nlus a nassl iriteni. shoula have en immediate povorful effeet in snall arounts, uhen reicased as a aerosol or powder. If would be ver ofroeive if introduced within Lhe body iy a dart, nte. It, has little or no efrnet if it gots into a small break in the skin or if taken crally.