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psychiatrist at,tho

anpeared to have an unusual degree of knowledge and interest in chemistry, for a psychiatrist. His main intcre:ts in the gen'l fieid under discussion are inhibitors of glucose combustion  acetyl choline estcrase inhibitors.

said that thiaminase had heen suggested as a giucose combustion inhibitor." (Review: Yudkim, Physiol. Rev., 29, 389 (19l9) ). However, it is improbahle that thiaminasc could he developed into a good covert weapon. Since it is protain it is ineffective if given by mouth; it rust be injccted or inhaled. efelt that the amt. required to effect a nsrson with adequate dict would ho rather large for optinum value as a ccvert wcapon. Anti-thiamin compounds vere discussed, but they tio not seem too promising as covert weapons because of the comparative large ants. uhicn :ould probably he rcqiired to produce a noticcable efrect on a individual with an adequate dict.

mentioned radioactive ascorbic acid. It may bd effectively givên by mouth, injecticn, or inhaled, and it tends to bo concentrated in glandular tissue. indicated that a very small amt. of the material would produce destructión of the adrenal cortex. Even a slight danafe to the adrenal cortex would produce symptons charactcristic of Addisons disease-- disturbances in sodium and potassium metabolism and in clucose metabolisn. Severe Addisons disease, if nct properly treated, will result in death.

C seneral field:ave the names ofséveral individuals who are active in this

felt that sedatives such as barbiturates are about as good as anything hc knos as interrogation aids. le thought alcohol vas about as good. lle felt choline esterase inhibitors should he invest. as antipolygraph aids.

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lle said various shock trcatments are effective in producing amnesia. Insulin shock is not effective. letrozol shock is effoctivc, but it is a sloppy method when usod in actual practice. lie tiought several repeatod clectroshock Lrcatments civon in one day nost satisfactory procedurc. lie said the Japanesc used ordinary ll0 volt alternating current in psyehiatrie. practico during the war vith avparently satisfactory rosults. lle said alternating current produces more confusion than does rectified alternating current, and a square wave rectified current produces the least, confusion. There is a discussion of this in a recent issue of' the Bulletin of Math. Diophysics.

Polysaccharide or protcin, trade name, "Pyromen". A dose of i or 2m, gives a fever of less than a degtec, but a ten-fold incrcase in dose would produce a definite clevation in body temperature. Althoughthe chemical nature of this material would indicate it would notbe effective\_if given orally, it should be cffective as an aerosol.

A 21 Teb 52,

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nas devoted most of his life to the study of curire alkaloids. le has spent a nunber of years in ho rorion of there he studied native uses of curare and learned native netnods of purifying the crude materinl. In this country ho devoloped a method of cbtaininc mure d-tubocararinc chloride from the cnido matcrinl. lie has sot up the rih order o mf. d-tubocurarine chlorida. lic conirnls all steps in the nfg. of the protuct. liost of his prodiuct is soli to pharn. housos, and he apparently makes the highest grade of purifint curar? alkaloid produced in this country.

At tho present tine the comnany has four Full-tinc cimlovens plus a variahle numor of pert-tine sivlent onplovees. The averao ronthly ontrue of d-tubocurarinc chlcride is 3.5 kilogroms.

Pescarch propesais for nedical annlications: 1) Iont-cctin curaro prorarabion fer solf-ninin. 2) Gurare preperation for field nerve gas protection

mentioned those nen as boins acrmainted with his work and the generai

Ideas on covert usn: a. parhially purified curare is used succcssfully byAn nativas to kill. cano and enories.

b. Very finely divided erude curare (preferably ef the stryehnos tyre) plus a nasal irritant had an almost paraling affect hen rcieasod as an anrosol or povder. c. Tho erdo naterial contains toxiferone compounds uhich ar" ox'renoly toxic. licwover, develoning toxiferone connods Cor corert use wonld be corparetivel lifficnlt tecause of the tine mnd vork it would take to extrnet identify, and tos'. iniividnal Lexiferene cornoumds. d. Fartiati ruricied crede curere ceuld be casy to obtain  have resstilitier cor cor ases. It is nore pobent Chan mro d-tul ocurarine chloriie. Tt, has oth th d-tubecurarine eulerido srovertios ani shat are usnaiy cons dered undosiraris side offests for curaro used in medicine. Theso adriitienat affects invoive histamine-like renctions. This natorial plus a nassi riteni. shouli have en imediate pcvorful effset in snall anounts, uhen reicased as a aerosol or powder. If would be ver ofrncive if introduced within Lhe body iy a dart, nte. It, has little or no efrnct if it. gets into a small break in thc skin or if taken crally.

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