35-C00149503

[PAGE 2]
Alcohol Antagonists

l. Attention is directed to your memcrandum cntitled "Alcohol Antagonists," dated 5 July 1952 and directed to Chief, Medical Staff. Comrrehensive review of current medical literature has not revealed a single specific and reliable alcohol antagonist that fulfills your requirenents.

2. Dexedrine sulfate, pervitin, and benzedrine are the most effective available drues for this purpose in the order given. Specifically these drugs are not true alcohol antagonists but serve to mask the effects of alcchol in the humnn subject. Any of the above drugs in doses of 20 mgm taken an hour before and every four hours while ingosting alcoholic beverages would partially counteract the discernible effects of ethyl alcohol.

?. The only effective and applicable adsorbent is that found in large quantities of protein either in the form of animal protein or milk; e.f., a heavy protein meal reduces the absorption of alcchol frcm the digestive tract by 50 per cert. Mineral oil or olive oil in two ounce doses vill effectively delay the absorption of alcohol but will not prevent it.

L. The B-cemplex vitamins definitely accelerate the metabolisn of alcohol by the liver; however, the unavailability of ornl preparetions of these drugs in the sassive doses necessary and the unpredictable time necessary for their action would minirize their value. The insulinglucose mixture is cf doubtful value and would be ill-advised because the insulin must be given by injecticn.

5. In surmary, the most effective available method of comtatting the effects of alcohol would be the combination suggésted helow:

a. 5-6 tablets of concentrzted E-complèx vitarins.on-the day that the alcohol ingestion is to take place. -

b. 20 mgm dexedrine about one hour before befinning the ingestion of alcoholic beverages and 2n mgm every four hours while partaking of such beverages.

c. The ingostion of a heavy protein meal shortky before rartakine of alcoholic beverages. (Alternatives - two glasses whole milk; one Elass crean; laree helping ico cream; two ounces olive oil; or two ounces mineral oil.)

C00149503

e/0, I, 64, 26

IE:CRANDUI FOR: Director,

SUBJECT:

19 August 192

[PAGE 3]
6. At the nresent. time there is little attention in medical research teing directed toward counteracting theimmediate effscts of alcchol in order to mintain sobriety. This field may warrant further investigation by the aprropriate division of the agency.

7. In this memorandun we have attempted to extract the salient factors certinent to your croblem. This office would be rleased to confer with your staff regarding more detailed information if so desired, and to asslst you in the solution of any problems of a medical nature which might arise.

/SSD/AL/1D

Distribution:

Orie and 1 - Addrsssee 1 - C/:S 2 - AL/!D (file) 2 - RI

C00149503

[PAGE 4]
SUBJECT: Alcohol Antagcnists

"ero from , same subject, dated 12 Soptemper 1952.

l. Proliminary discussions have been held with Chinf, Chemicèl Divisionots regardin: tho deelonment of a research project; subject, Alcohol Antaronists and Accelerators.

E. Both OTS and the 'edical Office feel that this Droblem is worthy of firther investigatien providod that thero is an cperationel need for such substances. It should be noted that such a project will require considereble basic research and testing.

3. It is reccmendod that your offico nropere n more detailed requiroment for. submission to Chief, Chemical Di-ision/nTS so that sreliminery studies mny bo instituted. The Medienl Ocfico will be hapoy to assist OTS in the medical evnluation of this project as needed.

C Assistant Daictl Ofrice

Distribution:

Orir and 1 - Addrcssee 1 - RI 2 - File

C00149503

4j13,2,64,28 7.4147

29 Soptember 1352

[PAGE 5]
Alcohol Anta-onists amx! Accolerntorn, lesenrch and veveloment !'roject.

l. lcforence is made to the moaoraruiun datod 12 Leptanber 19r2 fro the Me to the edical ffice, a copy of which was designated for Ti, and to the momorandin dated 27 eptenber 1952 fron the Modical ffiee to

sottlny out cortain viays resuitirg fron discussions txetvarn Iof the Hedical ffien and

Chles, Chanilcal Livision, Tis, concerpinr the a'ovs matter. It is thn belief of this staff that thero is sufficiont operational reed for useabla alcohol antaconists and accolerators to justify the institution of a rosearch projeet to-dotorine the foasibility of devloping Buch substances. If the basic resenrch indlcates that development is fensible i's io felt that It should bo extended to doveloo adeqni? Jbstuees In this fleld. ∴

7. Thie ataff, do to lack of techrical fanil'arity vith the sutjoes, is aeuhat hondieaped in preparinr a antallad requirenont for such a project.

3. A diatbnct ajorationnl reed would be, sarved by the\~- develoment of subatances having the folloving properties:

a. /lohol Antaoiatat a suistanee whlch cnn Lo kopt readily avallable and vhich whon takeninternally would Inhitit tho full cffects of alcohol consuaption for reacouably pmuetahlr rlods i ti,deaenoine upondnare. uuca substanve, o be useaile, shuld ot couran have n ill effects and partleularly chouldl net affect in any way We reasonine, s eceh, locorotion or alortness of the neruon thklas ite

b. 'lcokl iccolarators: an niIees, tasteless, colrlens substane uhle: wuld bo readily adniaistered in fost or drirk and vich weuld have be cffet of acerlerating the rsults of alcohol comaumption, il poasihle-rosultirc In a releage of Inhiisions and a n:ro raid loss of conirol on the part of tho irblber. nter iha fcasil:ility of such n substanco is not moxn to this staif but it is suegostod that at lenat this be conaidered ma a possibility in conectlon vith t.hs necessary resnarch to be conducted on the various phsses of mjectT

C00149503

A%,I,64,29

MilEJu! Fon! Chief, Technleal Supoort

[PAGE 6]
ACTI

he If tudrrd fesl e oraetieil,it l regunsted that C,in eotion with ee 'eilenlffi a! with Tc uviortuke a ranarch en: develoront projec!todevalnn substanres possdssine the aroportles mughly sutlired atove. It dn ceiicved that thie rotct nirht unll he rzdoà rt of !rojnet ATIOOK.

C00149503