MORI 149503

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l. Attention is directed to ycur memcrandum entitled "Alcohol Antegonists," dated 5 July l952 and directed to Chief, Medical Staff. Comrrehensive review of current medical literature has not revealed a single specific and reliable alcohol antagonist that fulfills your requirenents.

2. Dexedrine sulfate, pervitin, and benzedrine are the most effective available drugs for this purpose in the order given. Specifically these drugs are not true alcohol antagonists but serve to mask the effects of alcchol in the human subiject. Any of the above drugs in doses of 20 mgm taken an hour before and every four hours while ingosting alcoholic beverages would partially counteract the discernible effects of ethyl alcohol.

3. The only effective and applicable adsorbent is that found in large quantities of protein either in the form of animal protein or milk; e.f., a heavy protein meal reduces the absorption of alcohol from the digestive tract by 50 per cent. Mineral oil or olive oil in two ounce doses vill effectively delay the absorption of alcohol but will not prevent. it.

4. The B-complex vitamins definitely accelerate the metabolism of alcchol by the liver; however, the unavailability of oral preparetions of these drugs in the massive doses necessary and the unpredictable time necessary for their action would minirize their value. The insulinglucose mixture is of doubtful value and would be ill-advised because the insulin must be given by injecticn.

5. In surmary, the most effective available method of combatting the effects of alcohol would be the combination suggested below:

a. 5-6 tablets of concentrated B-complèx vitarins. on-the day that the alcohol ingestion is to take place. -1

b. 20 mgm dexedrine about one hour before becinning the ingestion of alcoholic beverages and 2n mgm every four hours while partaking of such beverages.

c. The ingostion of a heavy protein meal shortly before partaking of alccholic beverages. (Alternatives - two glasses whole milk; one glass crean; large helping ice cream; two ounces olive oil; or two ounces mineral oil.)

P/0, I, 64, 26

!ECRANDUI FOR:Director,

19 August 195

SUBJECT:

Alcohol Antagonists

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6. At the nresent time there is little attention in medical research being directed toward counteracting the immediate effects of alcchol in order to mintain sobriety. This field may warrant further investigation by the aprropriate division of the agency.

7. In this memorandun we have attempted to extract the salient factors certinent to your problem. This office would be rleased to confer with your staff regarding more detailed information if so desired, and to assist you in the solution of any problems of a medical nature which might arise.

/SSD/AL/ND

Distribution:

Orie and 1 - Addressee 1 - C/:S

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SUBJECT: Alcohol Antagonists

REFERENCE:

"eto from , same subject, dated 12 Soptemoer 1952.

l. Preliminary discussions have been held with Chinf, Chemical Division/oTS regardin: tho detelonment of a research project; subject, Alcohol Antagonists and Accelerators.

2. Both OTS and the "edical Office feel that this problem is worthy of firther intestigation providod that thero is an cperationel need for such substances. It should be noted that such a project will require considereble basic research and testing.

3. It is recomendod that your office nropere n more detailed requiroment for submission to Chief, Chemical Di-rision/oTS so that sreliminery studies nay bo instituted. The Medienl Cofico will be happy to assist OTS in the medical evaluation of this projoct as needed.

G Assistant Daiutl ofrice

Distribution:

Orir and 1 - Addrossee 1 - RI 2 - File

Pj13,2,64,28 7.4747

29 Soptember 1352.

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Alcohol Anta-onists an! Accolerntor", lusenrch and vevelopment Iroject.

l. lieforence is made to the meaoraniun datod 12 Leptenber 19r2 fron the Nce to the radical ffice, a copy of which vas designated for Ts, and to the memorandn dated 27 beptenber 1952 fron the Nodical offiee to settlny out cortain vieys resuitirg fron discussions betvorn lof the Hedical ffiee and

Thies, Chenical Division, Ois, concerninp the a'ove matter. It is the belief of this etaff that there is sufficiont operational reed for useabla alcohol antaconists and accolerators to justify the institution of a rosearch project to dotorine the fensibility of developing Buch substances. If the basic resenrch indlcates that development is feasible it is felt that It should bo extended to develon adeqnie Jubstmees In this fleld.

2. Thia ctaff, de to lack of techrieal fonil'arity vits the stjocs, is smevhat handieapoed in preparinr a detallod requirenont for such a project.

3. A diattnct ajorationnl reed Nould be, served by the\~- develoaent of subatances having the folloving properties:

a. Ilcohol Antaouistat a suustance whlch can Le kept readily avallable and vhich when takeninternally would Inhitit tho full cffects of alcohol consuaption for reacouably prdetahlr rlods o ti, deaenoing upon dsace. uucn a substanra, to be usealle, shrule of courau have nr ill effects and oartteularly chould not affect in any way ue reasoning; s peech, locorotion or alortness of the peruos tilas ite

b. 'lcokl iccolerators: an nioIess, tasteless, colrlens substace uhle: sould be raadlly adniaisteret in fost or drirk and uich weuld have bo cffect ef acerlerating Lhe rrsults of alcohol copmumption, il pearihle-rosulting In a releage of Inhinitions and a nuro raid loss of control on the part of the irblber. oter ihe fcasilillty of such a substance is not moxn to this Staif but it ia suegostod that at lenst this be conaidered ma a possibility in conectlon vith t.hs neceseary resoarch to be conducted on the various phsses of rojeet TT

A/,I,64,29

HPtENJu! FOR! Chief, Tochnical Supoort

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ACTT

h. If tudrrd foesl eoreetieal,it in regunsted that Ci.in eoorition with ee'eiienlffi ar with Ts, uaiortae a reoarch an develorent project to devaln substanres possdssine the noportles muahly sutlired aove It is teiicved that thie rotcct nirht uoll he pzdo à nrt of Prainet AFTIOOK.

fasn conien tot icnl fsic, hieí,! √