84-C00149553

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VIi : Chief, !edical Staff

FROM : Chief, Frogram Coordination DIvisien, Nedicnl Cffice

sUBJBCt: ARTICHCKE; Evaluatien of lypospray

1. The Medical Office has completed preliminary invostication of the Hiymospray. In view of the many dorrogator findings, it was felt alvisable to submit this report so the merits of the project zay be re-evaluated.

2.

. are the princiral commerical firs conducting research in the development of the Hypospray. Responsible officinls of these firms have beon contacted, debriefed and the research resuits evaluated. These officials uniformly arreed that the Hymospray has not proven to be successful and thus far is not a satisfictory substitute for the standard needle and syrinro injection techniqus. They concurred on the following specific details:

a. The Itpospray dces not provide consistently painiess injection.

b. 3leedine rerularly accemronies jet iniecticn, similer in deeree to that encountered with needlo injection.

c. Any moverent of the device during injection resuits in muitiple lacerations of the skin.

d. The Htpospray night rossibiy inject through the thickness of a shirt, but the administerer lose wouid be iocreased, ani the iniecticn wculd not be steriie. It is not felt injection through clothing would te effective.

e. The effective lose teliverei ani the depth of renetration cannot he determinel accurately.(Sonsequentir, the rate ef absorption and eventual effect of the t:me drur used in ARTIChCtE work cannot be predicted with acceptable accuracy.)

f. The Ibpospray cannot be usod for intravenous injecticns. This is simificant because interrogatien tcchniques utilizing drufs require use of the intravenous route.

c. IThe jyrospray can adainistor a maximum of 1 ee. of material; in orler to aimninister 2 ec., the devicc weuid have to be at least doubled in size.

C00149553

To: Doputy Director of Security

DATE: 8 April 1253

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h. Ampules containing 1/4, 1/2 and 1 cc. of medicution have been devoloped. Cf the t:o or three types developed, none have proven completely satisfactory.

i. The Hypospray is capiblo of injecting practically any solution, even those quite visccus. Suscensions can aiso be injected if the particles are not too large.

j. The hypospray is the most effective jet injection device developed to date. It is approximately 9" long, 1 1/2" in diazeter and weighs l200-l500 grams. Many experimental models of smaller siso have been devloped, soze of fountain pen size, but these were discarded because they contained only 1/50 cc. and the effective amount administered varied considerably. Five experimental jet injection devices were exained at the and thirty five at them!-:

k. No way has been found to eliminate the noise made by the instrument at the time of re easo.

3. suggested to theResearch Dopartmentof the that tho size of the ltypospray might be reduced ty utilizing a comoressed ges such as nitrogen as a power scurce. They felt such a device wouid be mechanically feasible and would probabiy reduce the size considerably. The Fesearch Director\_stated that a project to develop this iniector would cost about ta Such a device would probably not correct the cther objectionabie features listed above.

4. The Nedical Office notes vith misgivings the gonerally pessinistic cttitude of thcse engage? in the resoarch and develop ment of the lbypospray and their tendeney to regard it as a "wtite elephant". The impression was Fained that the major objections are intrinsic to the jet injection principle and will be nost difficult to eliminate. This Office canrot help but feel that the fypospray is of no value in its present statə of development ani that the project should te atcandoned except for periocic hecks with the researchers to follos prcgress made. In the event a jet injection device of sufficient merit to be acceptabie for gereral medicai use is developed, steps would be taken to determino the possibilities of adapting it for clandestine use. The further re finements reqired for clandestine use wmuld include elimination of noise, decrease in size nnd study of its effectiveness through clothine. since these are minor factors in its genoral medical use.

5. Decisicn as to the fiture of. the project rests with Insrection und Sacurity Office Staff, due to your froater knovledge of pctential operation uses of the device. Investigation has been halted pending your iecision.

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