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MEMORANDUN FOR:

SUBJECT:

Add-on Task at the

1. This add-on task is a long-planned portion of the Materials Analysis Project. The purpose is to establish an efficient and rapid method of determining the mechanism of action, tissue reaction, and potential for creating states of dependency of candidate psycboactive agerts. The work will undertake to establish a tissue culture systen for the study and classification of newly acquired or synthesized compounds. Initial efforts will utilize weli-established compounds as the developmental test bed. This will entail the use of psychoactive anagesics such as narcotics where tissue culture dependency or "cellular addiction" has been shown to occur.

2. was selected for this research because of their experienced and able ataff and because the work is an integral part of the drug screening program now established at this facility. This screening effort feeds into a computerized system which is compatible with Agency programs and existing bardware. It will be necessary for the output of this work to also be compatible with the Agency's system.

3. Assuming success in developing a tissue culture system that yields new, useful information, it is expected that follow-on work will be required at about the same level of effort. It is also expected that some savings will accrue as a result of better selection of candidates for secondary and advanced screens. The work has been coordinated withThe work wil cover a period of nine months at an estimated cost of

4.Dr extensionis the project
officer with responsibility for monitoring the work. The work will
be UNCLASSIFIED, but Agency association will be CONFIDENTIAL. Reports
will be classified AS DIRECTED. 0

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29 March 1972

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29 March 1972

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