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MEMORANDUM FOR FILE

SUBJECT: Project Proposal by Dr.

1. The basic research concept is well planned; however, the following sug gestions coe to mind:

a. I do not recowend tha exclusive use of dogs--actually 1,l00 in number. During the post 5 yeaxa, there has bean conəiderable research on electzo anesthesia in the U.S. with anioals of all kinds. Ia spite of thia effort, little is applicable to electro-anesthesia 1n the buman.

b. Preliminary investigations might well begin with the dog in order to develop technica peculiar to inducing electro-anesthesia and in monitoring the condition of the animal during and after paesage of electrical currents.

c. Pollowing the use of a reasonable number of dogs--parbaps l00--the research should be directed to the rhesue monkey where the subject can be used repeatedly day after day.

d. As soon as expedient, the observations ahould be transferrod toa few chimpaazees, which, lika monkeys, can be used repeatedly. varying the electrode placemant and nature of the electric currents with continuoua monitoring of the animal.

shmed biutlya. 0.Pinally, concurrantly with observations on the chimpanzee, human subjects mey be paid volunteers oz perhaps patients in a psychiatric ward of a hospital

2. Comments re numbered paragraphs in proposal are as follows:

a. I.A. - I do not think it necessary to atudy all posgible variations of electrizal currents. The moet promising values oi frequency and intensity should de followed up as suggested by the present observations and published resulcs of other investigatora in this field.

b. I.B. - Placement of electrodes may be very important and certainly will differ vith the species of animal. Tha intansity of the currents will vary probably with animals speciec.

c. II. - General anesthesia would be more Lmportant than local effects. Again it ahould not be necessary to perforo major surgery in order to ascertain the extent of the anesthesia induced. khy should drugs and $\mathfrak { o } _ { 2 }$ not be used in the studies with dogs?

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13 June 1966

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Iv. Implantation of aix chronic electrodas within the brain to moastor the electric curzent, etc. may well influence tho current distribution ie tho brais. Perhaps modela could be used. fos these studias.

f., V.B.e Why. not consider electromyographic recordings in case the motor cortax is stimulated. Aleo, electromyography should be of value in deterniining the relaxation of muacles. desired in aurgery.

g.  V.B. Methoda for determination of ths depth of anesthesia are presently unsatisfactory..Pinching the oar ia used frequently. with tha monkey. g.:V.H..- Post-operative observations in soe cases should be extended for savaral daye.

hV.J.Suggeated wave form combinationgBeem unneccssarily complicatedSincethereseems to boe species differencs for animals, why plan such :a complite. series of wave form combinations for studies. iovolvingonly doga! e

3."Concerning the budget for this proposal, too many dogs (1,100) and uneccgeary surgary.are-planned. No. continuous recording equipmentfor .B.:is listed--only indicatinginstruments.

4.. If I recall correctly, the statement wes made that Dr. ín 2 yeare willobtain.a PhD. degreeia physiology. Although Dr. 1s.avell-qualified D.V.M. and experienced in.electro-aneathesia .with snimals, will there be a deuror physiologiat consultant. in the propoaed program. of research? Also," an.electronics engineer should be availabla.'Tha Project Propoaal does notlist the qualificetions of..Dr. or any of the technicsl assistants associated with the oroerem. the program.

.:I hope my coments are not interpreted as opposing the avarding of contract'to Dr. IHe-ls highly motivated,interested and experienced in the field of elactro-anesthesia and I nope that bo can modify his program to include .some.of the.suggeations listed above.

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