MORI 190874

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T'ransmitted herewuh are the clinica reports of tests conductedduring July and August 195o. The outside temperature was very high with a constantly humid atmosphere. Tests were conducted in non-ar conditioned buildmgs and astimated ins de temperatures ranged from 7o to lno) degrees F.

: Test #l

The drug used in this case was sodium amytal intravenously, 5% solution at the rate of 1 cc a minute. The stimulant employed was benzedrinc ntravancously at the rate of 1 cc a minute plus 10 mg given orally at the complelion of the techni que.

The intravenous injection was begun at 132. At 1342, 9.4 cc had been administered. At l345 the Subject was sound aslecp. Il. was possible to arouse him but in order to obtain the exact state desired intravenous benzedrine, as a stimulant, was administered. At l405, he was accessible, but his speech was quite thick. At that time 1 cc more of benzedrine was given intravenously following which he was in the proper state for the interrogation. The interrogation and other conversation was continued until l449when the Subjcct was told to g to sleer, which he did. At l453, he was given 2 cc of th: benzedrine solution, follow ng which he became quite wide awake. At 1615, 1 benzedrine tablet was given to be taken orally, the dose being 10. mg.

The Subject had amnesia as to his conversations under the influence of the medication. This test was regarded as successful.

Test#2

The drug used in this case was sodium amytal intravenously, 5% solution given at the rate of 1 cc a minute. The total amount administered was 16 cc or 7.8 gm. The stimulant was benzedrine, 20 mg, 2-5 cc intravenously. A total of 9 cc was given or 36 mg. The injection was started at 1l4l. At 1152, after the administration of 1l cc of sodium amytal solution, the Subject said his head felt woozy. :At ll55, he was nearly asleep but awakcncd with a start upon being aroused. From that time on, he was occasionally given l cc more of the solution in order to maintain the proper state for the technique. At 1230, he was again asleep but easily aroused and the sarne at l245.

∴: The desired effect of the mcdication was obtained. The Subject was interrogated under simulated enemy conditions and he was quits violent upon occas:ens during the interrogation as he was convimnced thit the :nterropators were his rnemies. At 1250, the stimulant was begun and although he gradually awakened, at 1259, after the adm nistration of 7cc of benzedrine solution, he said that he still feli. sleepy. He was given 2cc more al 1303. At 1353, he was awake. At 1404, he was sent to eat and then sleep. He said he still felt a l:ttlc dizzy.

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The Subject hid amnesia as to his concersations under the influenct of the medication. Ths test was regurded as successful.

T=st #3

The medication administered was sodium amytal intravenously, 5% solution given at thc rate of l cc a minute. The stimulants were benzedirine intravencusly and picrotoxin intravenously.

The total amount of sodium amytal administrered was 16 cc or 0.8gm. Thz amount of the benzedrine slu ion totaled 5 cc or 2) mg was given and 1.5 cc of picrotoxin. 二

The medication was begun at 1048. At 1l06, after 1l cc had been administered, the Subject compiained of blurred vision. At 1ll2, following the administration of 12 cc (total), his eyes seemed heavy. At ll2l, after the total administration of 16 cc, he was found to be yawning. At ll2?, he was aslecp but could be fairly easily aroused. At l2l2, the desired effect of the mcdication was obtained anl at 1215 successful interrogation was begun. At 1247, the stimulant was begun, that is, benzedrine intravenously. At 1252, a total.of 5 cc had been administered and although the Subject could be aroused, he still scemed quite sleepy. At 122l. picrotoxin was given, a total of 1.:5 cc. At 1226, thc Subject was awake. However, in the afternoon after having had his lunch, he was visited in his room at l445 and was found to be slccping soundly.

The Subject had amnesia as to his conversations under the influence of the medication. This test was regarded as successful.

Test #4

The medication in this case was sodium am;tal intravenously, 5% solution administered at the rate of l cc a rninute. The total amount of sodium amytal was 15 cc or ).75gm.: The stimulants were picrotoxin intravenously, total 2 cc 1 and benzedrine, 17 mgorally.

The intravenous sodium amytal was started at 1524 with 7 cc being given at the rate of I cc a minute and then a few minutes were allowed to elapse to observe the effect following which 2 more cc were given. A waiting period again followed with 3 more cc being given and then again a wailing period followed by 3 more cc and finally 3 cc at l604. The intermitient nature was to kcc !he atient at the proper point for the interrogition. At l6ln, the adlministration of 2.5 cc of picrotoxin hid been complcted. The Subject still slept f:llowing this by permission for 5 minutes. He was then awakened. At 170l, 1.5 cc of picrotoxin was administered and at 1795, 0.5 cc of picrotoxin. Thc Subject, at that time, was awake but said that he felt sleepy.: At 1720, 10 mg of oral benzedrine was given.

2

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1 The Subject had amuesia as to his conversations under the influence of the medication. This test wis regarded as successful.

Test 45

The drug uscd in this case was sodium penthothal. A 2 1/2% solution was given intravenously. The first. l) cc was given at the rate of ¿ cc a minute; beyond that, l cc a minute. T'he stimulant was benzedrine, 1n mg orally. The total anount of sodium penthothal was 19 cc of the solutien which would represent not quite 9.5 gm. of the drug.

The ntravenous sodium penthothal was started at 1lo0. At 1175, 1) cc had been administered. At ll07, the injecticn was again started and this continued at Illl, 4 more cc having been administered. At that tlme, the Subject dozcd off but was easily aroused. At lll7, the injection was again started and this continued after the administration of 1 more cc. This procedure of giving 1 cc intermittently was repeated at 1122, 1125, 113) and 1134.

The original ian was to give an intravenous stiimrulant but the needle had become clogged due to a blood clot therein and it was believed to be inadvisable to have to make another puncture, hence, the stimulant was given orally at l222 (10 mg of benzedrine). At 1235, blick coffee was administered. The Subject was then instructed to rest for a half of an hour and then eat his midday meal.

The merlication was effective as to the desired results. It is believed that : when this particular drug, sodium peutothal, is used, the ethod employed in this case is best, that is, after the initial stage of impaired consciousness be produced, it is advisable to give intermittently small amounts of the: drug in order to maintain the desired state. When using sodium ainytal, however, due to the more prolonged effect, it is not so necessary to inter-space minute doses in this way. The advantape of sodium pentothal is that it is much easier to have the man back in his normal state in a comparatively short timne but it is not 1 certain that the amnesia will be as definite as in the use of the longer acting drug. In this particular case, ainnesia for the interrogation was produced. Also sodium penthothal is slghtlymore dangerous than sodium amytal in the more rapid production of respiratory failure.

∴ The Subject bad amnesia as to his conversations under the influence of the
medication. This test was regarded as successful.

Test 46

Sodiuin pentothal, intravenously, was used in this case, 2 1/2% solution
at the rate of I cc a minule.: The total amount of sodium pentothai was 9. 4 cc
of the solution, represcnting approximately 0. 24 gm of the drug. The stimulant
was intravenous coramine. ;