34-C00149502

[PAGE 2]
C cen t

1. Doder sover of being a oonsaltaot to … risite weare made to o11d

8. (Crade eurae, a cried extract of ceriain Bouth Aerioas plaots, bas beoo weod as an aow poison by South Aserlsan natires for myear.).

( puro mtarial rralues panlysis of volumtay mecleo, vioh akes it a wen nnct to stheoio Lnaurory.)

J. Carare bad rery Limitod ueetiness in zedicin bafare the sdrest a pure d-tubourariae chlorido because the sviiablo pratute ecotaiaed iurritiee sics mde te rerlte ram toe wae af the dnns ritberltptbdiotable. Thoe rone of the ans nor svallatle Rarently prxtkee cesentially predictable remults. Amll doece of d-tabocuarise chlorida rotnoes relaxation of ts sbeletal mucles. Larter caosts prate ais virn protuinstkeie ar eetics the stel grts. Dessos re  pealysis of th alee which ccatral wetris (esia), se alloid Lo mly Lortd e s as paluticny it is estestive in 12 to 15 accãa is taterted istrstrcmaly, ia 8 to La sirates if iatastod intrmosoaiarly. I Lutrocoed tsto the boty w astder sovocsre 1s io esteotiwe is 3 to 9 zisrtos, ( nierins to soasiosetio   esral:)8t is ntartinmiy

C00149502

DRAFT. 87 Peby 1952

[PAGE 3]
DATSEOE PEFCMLS POA IRRCCAL APILICATCES

D-tboourerine coriée in aquos solution acta ory rapily, but tbe effect also doorcases st a rapid rate. The rapid Laitial sotian ie often dosirable for seilisal woes bus the short poriod of effectire artirity 1s often& rions slolty.Ln arter to overc thiodiriculty, preperstions of thm alkaloid bare beea mte by inoorporcting it in s slov abeorytion base capeble of dalirering a olinically efrectire doce at s constant rate orer mn extenled period of tiz. A prodact prepered ty is incorporeted ia a bese consistiog of poamut oil, axcbolerteral deriratires, cnd beesxj thie ie sid by Bndo wdor the trate nese Tubedll. Sialler potte eeldbySgib (oootcining al d rioin) and Abbott (coctain al dx). ais aterial 1o of value is th trestasnt of trmumatio infuries booeuce a good deal of tbe pein and dissbility in mony cases sre  to uaclo spa. io can be coutrollod over Lons periods (18 to Bours vith ona injoction) vitbout the es of parootics. The dioadvantaze of those preparatioce io thct they must be vamd berore aso to obtain a hooteneous preparetion and it t be hapllod bypersonoriencca in irins injotione.

a. Long-octine Cuaro Pronarrion or Solp-odninigtration

1 A lanc-octing curaro pruparetion which coud bo rtlily pelr-aiminiotered (aiaptaule to use in npen, for inctanco) or nininirtarod by trcined cr utraiuc: inivisualo vnld be of great value in the Lmrdiate rulio? c. puin and diocbility arioiig rro injirios to tro or civiliane durinz var-tizo couditios. Iu y ccseo a dicabled peiuu u: lu returled to imdiato'cfrcctivaneos, in othera the catont ur Liunkility coull be maserially .reluacd.

rocis his cxporloe nni recliitieo woll Tallry his to doreiop a curaro epnratics acauie Por thia yurxse; he eola-ho c prom or loprrt tio fecoibility of hio luens vltbin bcot four aths. Bo voruld lika to olitain a mocarch ecetrect to dbrelop prennration vith tbcs opucilicationo: (1)) Hao a irdiate cae orrcct, (2) Eas a proions cure orrect; (3) Can b od is pen tye cquipent; (i.) Does zos rouiro prelininary banting or other proparatica; (5) Produces stcndari prediotablo rerulss. Be vants to proiuce averal praits, uoins dirferecs (curs.a-tpei) u capouis and rrious fonulatians ani subjest tixs to preliuioary anisal arpericntation. Bo oan anuigo cr purther imi oxperizontation and clinical tegt  ty c be do er to ydoui.

b. Cuars Proparation for Mold Jerve Gas Proto:tioa

balieros bo can procu a cuaro forulation yticd would be immodiete-actina,can besels-naiairtoredtor Lnotance, anpena), md.mich wll be far noorior to Borre Oas Peld Protection now available. is vould be a dirroront produr

C00149502

[PAGE 4]
(a) o, d o e rrid s L rit ati-ceies. De volá lise to Barea reszarch cootrars to develop his idoas. Bo os  e the ati   cnicl tastin weid be  to

(1)  aboe Ldees vere ofered ritbout bei3 aullcited or prapted by . I re eesrul totry to neithor veriy po dony any ldeas be bad vaiad touched on slassiriel Lotereote; no alasisied Larartio ms kovingly roluntoerei by o to

(2) 1  \$20,000 to \$25,000t1ato e to ror a reoóarob project referrod to a and b, abore. 5hn t vs gir  tho spur of the t ai dos not represeut e considerod estimto. I? thoan iotorest, bo vill nubit a nore cansidorcd ootisate cnd broek tbo figures dova to inlividual itens.

(3) Ir he cets a contraat from be intonda to outcin the sorvlns of (etor bo vuiI vill prubnily veccn asouciatod vith ia vtoc ho Ge a cuatrc or )

(4) sentiei Wee nen an lnin aguainted vis his vork ati tho cemrel licld:

S. IO OH JOER UR

Tiolluring Lirvort uncocut vo cutali C durine tho discuailcno viis :

a. ?artlally pirirlol cum 1s ux secossnully by Sonth Aoriean natis to kill son wul onenics. Tn ori in put on ibe tip or apoors or blos dnrtu  1t piiucus en clicat iexdiate piyais op th cl. dsacrlhed nutire rotbodo ad rosults avl abeved opolaens or thoe ogilpt

b. concarning posoibio military uaos or cunro lkaloiis. At hot ti thore ve 1rterost toomuso the Oenrns oei to be quite Lotorested in crudo curare. I vao rand thst very finoly eiriaed cruris curare (preserabiy of the oiryclinoa type) plus a nezal rritort d looot iliote pelysin eriost vhen nloni rosol or povder..  felt tie a ileuity vit cae

C00149502

[PAGE 5]
for litey w  te mriyo t mteriel (this would mo deatrmstage for cvert coe). Tere are may vatar ociabie ytotei viu yorlsiologiei poperties L mude curae, and the mesl irritart preclly Loeeesed the reto of sbeorption of e taie msteriel.

0. e sitmation has rapily changed since lghl, so tat nov far more potont acsate ess be ctainod ram eruaãe crae. he cnude material soutaiss reriserono capounds ror Kilitary torert) use vould be oaçaratirely dirtiols becanse or the tim ani wark 18 vonld te to etrsos, Ldentina md tort iodiricial teisere s.

. a. Pertielly puriries crue durar vouls bo eay to oten d have poseibilities for ilitary (dorert) uees. It is ore pobent than pue d-tubocurarine chlorice It bas bots the a-tuboeurarine ahloride properties and vhat are uounllr conaiierei udesirable side aftoote for orare used in modicihe. Teso additional crects 1ovolive hiataine-like reaction Lis material pluea paoal Lrritan abould bare en Lodiate povernl'eoct in mall mounts, wen roloasel ao nn aoroool or podor! It nuld to rory cfsootire 1f Lotstuluod vithin the lxely by a dart, ete. It bas little or no esroct 1 1t gete Lato a ull pronk in the skin or  taken orally. n?

0. uppurently tu/prianrily intarouted in the deronsive uo of ournr, but Lw anid bo beuld vory villinily cocparateia y vay he could in arythlin, iavoivie Liv defenwiw or ofreasive un o. cuaro alkaloiio.

5. ACTICH:

a. Pacs the Lufomitind in paragraph 3 along to for whatoor cction they foul deuirzble.

b. Obtain a TCP CEc mmrits cloaruno for and purouo the potentinl corort uoos of cuaro alkaloids nurtber.:

Besoareh Dovelog

whih are eftremel tofic, Hovee developmig tofiferene conpornnds

C00149502

[PAGE 6]
2. an this day, tbe vriter oontagted

cortact vas made through —00 51e1d statico. aocredited me to as a CIA representatire and thoo left and tho vriter alone.

the constriotor substance, banzodrine, and other sixilar drugs.

3. contral rerrus suotem dopreuiants nn' a!'unta, both in thieir yeripberal and contrnl maniroutationo. toconiutioronench vhore facilitieo and coposcuce coull bo erfoctive. of wy os suuutaics or olber attoro of interest to us in the reneral fiold or chnical muteriuls that aight bo or uue to us.

4. it 18 tho vriter's roelin: what amll, very sepsitive probic could te vory socurely carriod out

5. The folloving vpocil'ic facts were brought out in our discussion:

a. Indole analoguo of benzuine- mentioned a
vory intoreatins substance vhich thayran across in thoir
benzedrine.researobes. It is the indole analogu of benzeirioe. CH3

C00149502

[PAGE 7]
When giren at  doeaçs of 50 mg orally tbis compound gires the rubject a profound depression - jurt the opposite ofeupbora. nt uppareotly gires a deep-eeated dorprssion of-the central derrous syotea vaiah extends iato the mental spbere of mood snd alertuess. They Lidn't look Loto taa ay furtber beceuee is produced this very undesirable reaction. thinks thet may indole deriratives should be stadied ror this type of satirity.

b. L0 - Te discusmion toucbed pn LSD oaly insorer as inqulred as to vbether anyone vas Lockin, iato Laiale derivetives as struetural maiogues of LsD. Bo thoubt this field ahould be rtudied Latenaively in order to fini ccapnnds much aixpler then LsD in structure that bave the same kind of aotirity. o suucested that roefindout vtat has doe in indole conpounds.

c. liethylem droxy benzedrine- bes nnsvaroi the Tact that tho metbylene droxy analonw of benzodrine prodnoes ballucipetions mental images and mantal contuaion in doos or l00  taken orally. Toir studlov uo viaual Langery aul knee-jerk reflox iidicate prorbund Cs elrect ror this type or corpound.

d. yuatermary Salis -They discoroed tint tho bexadecyl tributyl ammuniu la ba vory high toxulty ndaialstered Lotrnvonounly in gva quutities.

e. Caponlcon Lu Ceanitian ith ronarches "deraturint lenzririn inhales", rown thut capauicen, the metive prinelpls ul' ! peper. al srn olopler ryathertic analoyues vere very esertim 1.n pralucing a hauraloss burning sanaation'on contaat.in cxtruwoly lov ccncouiratloms.

r. rlan-. iniluatod tiat a more or Loss comprebeneive piece of reoeirch bad teen dore during Lhe laot War at tho undor 18 the efricicy of Harijuenc for eleciting informtion. didn't kor ay or the dotaila.

g. indicated that the person in this country thet bo thinks is moet highly qumliried 1a the field of piamocopaychalagy along the lines Ln viad ve are Latorostod 18

….6。 indioated that. e would be villing to illout a PES fors 1f ve so desired.

C00149502

[PAGE 8]
taie do e viter briend on certain
reearch intereste and peads of . A dotalled tour of the
Feve also mde lator in the day.S, uide fro
the potential involved in his ow sclontiric aouon and in thore of his is obvioualy in itimate touch vith Frctically .

all the chezicel and pluarncentical cnusacturers on the makes tripe to waabineton frequontly and has acrvel to call the vriter vhon be is in tovn. 141-1

2.The conteat vith wes mode thrruih of the  Meil statlon vho intrluced tha. writer as a Cl repropentntive and then lort.

3. hnro a toohnical starr of about profcooional chaniets, biochenisto ad oniincert, nirl are currently petivoiy engagel in reoearor Ln tbs tollovin flollss

. Te phoieal racillties or the laboratory soes to be adoquate to do efroctive vork in these fields and the porsual that. the vriter contocted seoed vell trained and satbupiaatio.

C00149502

[PAGE 9]
'C00149502

[PAGE 10]
"1. Doder cover of being a conmultant to vas coutacted to disouss the technical nepocto of the dog loser problcm.In general provod to be an excoodingy. caupeteot ecientist, combining a brilliant, incosivo intellect vith. versatile interert in all phasee of buman poycholoy.

2. aisqualiried himoel? and bis dopertment fro any vork on sonoory pereoption in dors, pointing out t.hat thay had not a groat deal of opeciric uxporiance vith dogs as subjouto, nor dia tho have people strong Ln tho chaical and cagetoering disciplinos necossnry for this kiid of wrk."A dotailoi diccuosion of tho dog problcn indicstod that folt vory otrongly that the besio par tho rrenrekrthoula bo bandled ty a resonrch puycliologiat, strong Ln caparative auianl poycbology ani with a gool bnaksround in tbo disciplines mentionod aiuve.: e mucsted the folloving as aom likely caniidates:

.tirely meoliosted, mertioped somo zSP work in doge reoestly reparted in the Journal of Parwpayobolog. This lod to l disusion by hi of , vor'k ac rery recent

UU149502

[PAGE 11]
Aritisa work in thie fials. The witer orinoed no Lrtereut in this, bart is yas obvioms thns wes vitally Loterestod in this eab and dis disesion of the sbjees revealed the rollovine podatal

thiate thet ap is well proven, and thej ae starting worts Ln tis fiald st mnlcty is in proridins bot" wabjeets. Sone bave boes mcorored yot 2A.7"

De Britist work Ls mah dettar thann tie Duibe work to date. It is more Lmginetive and the experimento ae much better laid put.

h.ol ve desir, inieate a villinas tn 5ll vouil in as exsellent out s o. ho viter tin ailitian to soo's group a connultats, sino ve bave no ops aleared at the consultant lorel vioo 16 thormuihly copetcat to discus. Tarinue pyeholngical protlau,

C00149502

[PAGE 12]
a he bassa of C. ves togert critical epraieal of the couteaplatod resserck prog  verioe cicels for ue  covrs retre. C 2.  discussion of the produtio of rotrocrado mesias by At h  ly t let  to sia tooiqe

a. Mleotrorbock. beliores that clootrbock, repeatod
three or four times in tbe spaco of ono bour, ahould produce a bigh
dekrue of retrograde amesia. Le said it vauld bo almost ipocaible
9or tlem totest thls erxrimentrlly et beculo of the
sevority of. tbe treatuont. to. tue pationt. 6

b. "Icepick Oxration Uut elontr&hck iu prnhike avotheaie, a Waakington sureon bro ruy tizco muccosarully purrortelnn oporction inrolrins piereirs tlie urain 'uat cvor tie cye vith a Mino surgicel "icepick" rnd dootroyin? cortrin Prntal bruin tlesuo, vith pervaus cofusionel and csierrocts. Thi oerution loaros no mrke on t sicin.

3. T posoiblitie of usiit (t), privi, treole, i tennions, anti-ritwino, Be, an l.sD wes discusiel vith thought thuy all orrerod soxo prumieo, but voull plnco high O teneions and aoti-vitanins at tho botto or the list.. B thought that reeoarch to ansver our mpeciric queutions on ench of these oubstanoes vue pesded, Pertioularly. in the case of La. Bo was asked 19 any of the vork be ras sse of aold ansver our meds. Eis opludion vos that experinontal vork spoeirically desiged to our oporational poeds vould provide tbe answere. :1

4. montioed the Brpoprey Dtector end r pleesed to boar that vo were working o it. Bo gave the vriter sae Lnteresting literaturooesia.

C00149502

[PAGE 13]
MEKE FOR E KCE

auther of the toortant text recently pullabed

the falloving three Linos, with uny prompets ia. the plamnins stare 3. Mo cumont roseerch einirt at is bsin eiieotos elans

enect of is o tensios in monl an paebotic patie. 日 ell cerah st ponmel cortrals ae arallébio fra rolar sers and the hcepital rtatt preparatory ras mixtue is reiaod the nol 20% to .501 connuional offcots boea catients. nest in this r thet artaricl slerocis, shich 8. Bis is e reletively wcharaed fiold, rith dovioss implloatia Pne 18m0

[PAGE 14]
a. Vitapis B Dofieioscics- Sinoetho brain can use omly carbohyirate tor enorg, ed sinco the artabolien of Des's cole, B dericienries hare Puotionod brain disturbences. Acute B avitasinoeis satunlly ccuses permansrt dogeneratire drain damage. This would ees to open the possibility of uoing thiadno astogaists to prodoe conrsionai nd otber mtal states,.

b. Liptlessncss thinks thot s rational approeck to our urgmnt operetional romircuent for a abaodeal producig. a gaoral liatlesaness arvl lothary ight do in a. compouid vaies prodces ageoeral aritmainoois. Iis porntel out that the pemeral Lethargr and leok of produutironeos of the rery lov inoos sroups, in the soutbeastern U. 8. is due to aritamigosis for vitarins Ba, 0xd ieotinio sa.

3. indicated a desire to belp Ln my vas poeaidle, uged se to consult Purther vith his, and Lndicated his villineas to 1llts  for.  lso pid to sed  a  of s r proposal to the

C00149502

[PAGE 15]
contacted  Pebrmary 1953, es a ocsultaat to Ms ixterests include érus adiiotios, erus tolersoce, mnalgesia,
anustbesie, respiratery sysiolo, and ptarsoclogr of the central
rervous syetem. 24 disoueaod chemicals vich bane teea foud to tamparard inactirate or permaantly destroy sposiric portions of the marvous syrten. Keto ban Ldo is a such u.  It 1s eod Ln e to s etant i the troatment of drug addiots. bas foud thst 1s monkys are given ane larte sub-lotkni injoction of keto bonidon (0.18 .g.) they became caplotely holpless. Post mrton exminatipaof the braia sbovs thot tie vhite matter has boaa dostroyod vhile thero has beon no apparent eroot on the gray moster. Meosrous mnller coosa of the drus bas no much effact w mobxys. maid bo has triod this anly on skyo bece it may be srios opocirio. Riventil Ls a related comgound vith erracto vhich sxcest a sixilar actions These aompowds are nrlinarlly Lotrducel ly in!oction, Blthouh tluy vould probablybe ofrectire 1fzinisternl au nn norosol. 8-amino quinolinos vill destroy specirie contors of the brain. Bo mucsostod Lrvertigatins capounis vhiah hare boen testod for cati-cnlorial notivity in onier to find me about copounds vhich effoot opcciris portians of the norvoua ystan, Bs meution in this conmoction.

ou.sisias o o autilorial cos..

3. If monkys are expoeed to boary and repeatod doses of etkylans axide thoy Loee the nootion ar thair spinal chord, but the ponml neotiom returas ater resoval fros the gas. Accidental bumain poiscnings hare indicated a sinilar efroot Prom otbylons caics. The ocneniretiom of cherical required mis it out of the qoestion for oovert motirities, beas thw rmlts ae mrtiw.

said thay bave reveztly reosired sas moterial cailed ryeodioe Pras Merek. B was not cartaia about its chenical copeition, but is is pade froa Nacioan plane aad is dood

C00149502

[PAGE 16]
.Lnosctieide or rodantioide (be vs's mre vaich) in Bouth Acorioa. I 10 ioss er y to dog t podes maras of.Long duretion. e sp begin fairly idiataly. This mterial 1s boing iovotigeted L at the prasent tim.

3. are aleo voridiag on sthadols. Sare of those cuapouis pratuce an extended (36 to 48-ticure) los of ocnociouoss and revireible paralyeis. In monkys thera le mo apparont ofloct rum tho ccpounis until a couple of bours ar so arter tbe drug Ls Rivin. This group of copounds should be screened. m14 Lhnt

bas workod on sa of the clinioal aopoots of tio mothaiolo, but bo has bnd soe dirrioulties, so it is not curtnin vtotier be vill coutiaue this line of invostigation. vas mentionod as soother poosibility for vurk un motbodola. 010 that isto chonical stulios vould yiald rooults in tiis riold.

6. In to Piala of ahicnls vhich pro ontal darueat, bo doutnl that aytbins vrll bo round muperor to Li. o cousts tist zcsonline vill prore of Luob valuw. Bo queetiono the miue os cennibinol cuonia, Lnt nntlend

in thio fiell.  snla thr wuhnz intozication is probably  to muncorin, anl hat proatiii vld prvvably give .romulta.

1 1. wniol 1f tyl Ur wniid ru o vil 1o suorrilla t varfare. Lo uiovd cu t L0 an oorlno0 g  1s qulto polant.

8. w.uld to hiuly tc du wokfur us in his specifo rioldo o Lntorost. n 1s inred nlully in ail votk ri 1 nut cquppel to sythesize-ory.'c cionlenis. Binne at yrosont has a ooutrnct vith nothiocirlovillbe diocwae in gard to wirk until it cnn bo dotemizoi hat it can douo vitlous rumning Luto capctitiou vith tho=

C00149502

[PAGE 17]
yae eeetanted on te ovenins af 3 rodrenry 19s2.

seourity oousoions. epreseod bis ocntimalng coucers sboss eority 1dentificstion. and ased to se the rritere

appoared to hare ao uunual dogree of kovlodgo ea Lth

interest Lu cbemietrt,
general field under disousaion uro inbibitore of glucose eambution'and acatyl cloling esterase inbibiiors.

3. said that tillarinase bad beez sucgertod as gluooe oatustion Lahibitor. (Roviov naria, Praiol. Bor.,.89, 389 (1ghg)). Boverer it is improbable that thimianse could be daveloged isto s good covert vespon. Bince it is a protein it is Lnefsoctir 1f giren wpouth it mst be injeotod or inbaled. felt that the aaort regaired to efroot A loron vith adogeate diot would be rather larpe for cptisíes vaiue as s cuvert vapos.  Anti -taisin carpoande were liscussad, bat they do nos soes to be too praaisingas corert wes bocause of tho coparatiroly Large counts vich vould probebly be requred to prooe a poticosbls erres a Loliriel wts  aéogate asot.

6. menticned radiccctire aocrtia acid."Pis atpoers to hore pocaibilities s a cnert wpa. I y be effotirly cives zouts, injootion, or inaled, and is tenda to be eapcoutruted in glantules. tiare, inel Cas a vy all t  to

C00149502

[PAGE 18]
meterial voall protoe destrection . the ndrenal cortex. Sren a slight deee to the adremal cortes vould protmoe svaptons charscteristio of idéiecne dieease -Alsturbecse ia soiius end potassiaa setabolisa and in giueose mrtatolian. arvere séiieoms Lisease, L pot poperly trected, vill rencit is desth. Sisce Médioons disease is not vell uderatood and raticeetire ocutie mrid soula be ecuparetively sesy to dissininate, 1s is fals this poeslnility shelé be fartper Lareotisated.

gave the mee of sereral iniiriduaie vho aro aotive La this peaéral fields .

7. folt that sedatires such as barbiturates as sbout as good as anything be knovs es Latérrogatioc aido Be thought aloobol vas about as good. rolt choline orteraee inhiuitore ahould be Lovostigsted as aatipalygraph aids.

8.  seid various shxk trontzonts are erffoctive in pratuing mmesia. Inmulin mbock is not ofroctive. Metrozol abook is efroctive, but it is s slopyy metbod vhon vaed in actual practioe. Proper dose, rate or injection, ete. are difricult to doterzine for the produetioa of siren efroot. B thought thet rovoral ropeated oleotrio ahck sreatmata cren in ce dey ves the most satispactory procodure. Dader propor coniitioms this vill produce tempurary ammsia lasting ror a couple of veeks.

Be said tbe Japanesc usod ondinary 1lo rolt altornating : current is papahiatrio praotice during the ver vith apparently satisfactor results. Ee said alternatins current proiuccs mre conuice tkan does rectiriod alseraating curent,and s square vere roctifiod current produss the least coafasio. There is a diocussionof this ina raoant issvof the Dulletis ofMatbonstical Moptyaice

9. mentiosed an advertiscsnt be bad cent to about s palysaccharids or proteiz
sold mdar the treée nane Tyraaca", à dcse of 1 cr2 " gives a
fever of, less thz a Sagrso, bat a tas-fold inarosce La doee voad

C00149502

[PAGE 19]
C00149502

[PAGE 20]
2. An extensire Inopoction of the laboratory facilities under imoliate comtrol inillooted the folloring thinzsi:

b.Exoliont Paollities exiot for ay type of mlical researeb Loroiring phrsisloclcally notive cborical ocapomds. Bonsubyeets vould be araileble for work thct ovuld be carried out as logitiaote medioal resoarch. Lxtensire anizal Sncilities exist or otber kinds of ressarch.

e. Cootractual srrangomcnts via the metbod vould be very teasible. indicatad that it vould be necessary for only ons other person to kaov vhat be vas doing mnd bo tharofore nuggested thet be cleerel for this sort of vork. Be Lodisetod that both bo and vould be bapsy to 11llat p3 f0.

d.Current work in the Laboratory is corterel namly aroud rterilisation of blood y abemioal igaats to destroy virus ani spore

C00149502

[PAGE 21]
boties. "ia esteanive
this wark. An artiwe Ls ia eartcss aleet vontert vite clinisisiose, to the

b. Beryliuin- Tere's a ecaridorable litorature, mat of it etermring Tros recent accidante Lnovolring brcken fluoresoent lightins equisgt o the extr toxicity of barylluia. This is certeinly the ost toxio Lnorranio eluzunc ml it produces a pooullar Pibrotio tuor st tho site cf Loi cppliastion. Te nmnt noossaaryto prodnoe thess local turórc !s u fov icrogrrs. 85330ste stuy of the ofrect of inbnling ll enoumt's 0 bry 1n tho lumgs, and othor stuiies to ovaluate the poteatinlities of borylluia as a covert veapon. 7.

b. thougtt bis eould do an ertire jb0 stuyin ri LD agets by lxi one ar more objeti ndrasaf La0 spplication ia laborutory animals and sctvenins campouda that might ccabet its actiom.De vas Lovited by the vritor to Corolop this Loto resarob propoeel 1 he so desired. It vs ghsisoi tat no ecitant of nykiod vs Loralrod in our sooegtene afa reeach po

S..  rollosg entios jodicatod y te above ooussious erer

C00149502

[PAGE 22]
Cr

CTR

1953.

vaa ecstovtod cn 3 Pabreny ea cis voth tto cosistmm or and tn miarsigand azeoched

a reavmtatire of Is discnscios vich vas linited to ts rdjot et cnr-like acante. ● cellsgs af to Ls Latsertol in toxio puare copoale md ertiricial respirstioa, vas mot snilleble bocaucs of illnass.

2. Cruio curaro Ls obtainod by brevins roots, bark, oto., 0 cororel pecies of Bouts Anoricnn plante. It contains povornl almloids a is neod by cortain Bouth Amricen tribes so an arros poison. Ao indiriml or animal strunk by such a poisorsd arrov is rapidly reniered bolplose e to peralpsis of the skeletul rixles. Puriried cuaro anl chcaicals bering à ouraro-lie action ao uool ro nin extent in oriicine, han it La desisod to prolucs a ralaxation uf tre skolotal suncles rithout the prosution af sooetbesia or the produstion, af central porrous ayotea peoralysis.

3. said that a La-ço mrbor of ciurarw-like chodcala (moetyl pholioe blockins, ageots) hare beon proparcd and ocroened by pharmoosttical bousos such as Tinrpe and Dcts, Murmuch tolcome Co., Ri Lilly, Abbott, eto. A fow subotanoes vhich moot-Nedical roquiresnto are no  o mt, but bo said y vich vul o ly ot ar repiirosagts hare toon diecardod. Bo said thpt 1f ve vrote dovn the dosired spaciricaticns for e drug vith curnro-liks cotion, cad thon crarassed tho aras houess, ro voald miaabtodly find that a arus vtich reets tho speciricstiora Las bon scroend. Tio might te  rathor tinistic stetozant, but since 8 potant ourar-like nceat vould ts of value in corert aotirities, ao afsort miould bo madie to soe nt can bo obtaird by this msthad.

b. lorarnl iavostigotoro matiasd vo ars eotio in eotreaising or testirs copimis af tre evrare typel. D. Dovat, B. J. Be Bes, J: o. Eo, A. R. Lrto, V. . . Patoa, B. . Corizz.  vork thace and other mod La dosarited in the book Carere cni Aati -Curare Acoute publiabod by the Dov York Acadeny of Bcisnce.

C00149502

13,2,64,1

82087. 83 Poy 1952

[PAGE 23]
C 9. exyrvonnd ca iotoost in elipioal tosting of cerarele pls, brt s at te

6. s

a. Cotaia iaroratico sbut carsre-like cagods tich rv been scrconed dy ptarmceutioal bomns.

Chazical Braoch Researab à Dorelogsent

Orig 2 co .

C00149502