MORI 184548

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5. All ofthe above pea corclude that LsD-25 is a dangercus material and that it has s potential as a CW and Bli agent. These espects are socething they had not thought ebout pricr to our interest in ths subject generally. At this point their entmusiasm is running hich end they are very interested in pursuing the research to a conclusion. Tney prcposs that the follovingsubjects abcula beiavestigatods

:..1.JUN.1978.

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Resecrch on Alkeloids of Ergot (D-lysergic and diethylenide LSD-25)

Why voula any country be interested in obtaininglarge quantitien"of ergot or lts derivativest This question .is predicated on the fact that exclusive of ercot derivetives used in obstetrics, drugs obtained by synthesis in unlimited quantities produce controlled effects vhich are better than those obtained by ergot cerivatives. Therefore if any country or group of countries are procuring quantities of ergot and/or its derivatives it must be for uses yet uaknovn to US investigations.

b. LSD-25 is a potential "anti-anxiety" egent as indicated by tests conductedin EuropeSeeReports 3373and 33367. In viev of this, vnat vould be the effects of mess application to a populace or troops in terms of civil defense or offensive actionst It voulá be vell to determine precise peychic reactions in human beins and to develop a possible antidote.

c. It should be definitely deterained vhat quartities of ergot derivetives (LsD-25) would beneeed to effectively contazinste food end vater supplies..

6.We heve been assured by the scientists thnt they will cooperate fully in enything ve suggest. In this connegtion ve vould appreciate hescquarters' sugsestions vhich coulá be used to steer the experinents along lines most ussful to CIA and/or other government egencies. There is no imediate call for funds from CIA as Dr. and essociates:are interested enough to prcceed on available melical school funõs. Funās vill be needed later vhen humen subjects are hired (at approxicately vs\$l per hour) for experinents. The figure of Usl thousand is suggested as sreserre fund. Ve Vill eppreciate your reactions and sugsestions regarding thisproposal.

o o. 893 22 Septerber 1953