C00021917

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1. This memorandum contains a recommendation for your approval. The recommendation is contained in Paragraph 7.

2. The research program detailed in the accompanying proposal is part of the Behavior Control Project. The work represents an increase in our present-level of effort to identify pharmacological agents with new and umusual effects. Tne increase consists of new secondary screening procedures deemed necessary before any testing in humans can be initiated. For the first time, nonhuman primates will be used in order to accomplish more advanced pharmacological characterizations of compounds showing interesting properties in the primary screening procedures.

3. the contractor for this follow-on research, has during the past twelve months completed the primary screening of over fifty newly synthesized, novel compounds. At least twelve of this group show promising behavioral activity which will be urther characterized pharmacologically using more advanced or secondary screens with nonhuman primates. Included in the secondary screens will be an evaluation of the various compounds effect on social behavior of monkeys, mechanism of action and effects of antagonists. Over 400 compounds have now been acquired for this screening program, and a yearly synthesis rate of fifty compounds has been established with the cooperation of the pharmaceutical industry. The contractor will deliver a comprehensive final report and such interim reports as may be required by the Project Officer.

4. The proposed work will cover a period of twelve months and will cost approximatel was chosen to continue this work because their performance to date has been uniformly above the average of other contractors in this area of toxicology. Ir. addition, their cooperation in the industry-liason

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phase of this progran and their unique access to newly synthesized compounds were persuasive elements in their selection for this work. Coordination has been effected with and Edgewood Arsenal Research Laboratories, U. S. Army (Dr

5. This project, based on early findings, will bave a major impact on the Agency's potential for controlling muman performance and lor defense against exploitation of key, national personnel by vnstile intelligence services. Follow-on research can, therefore, be expected to contimue at the same general level of effort.

6. As in the past, this research will be classified
Association with the Agency will be classified SECRET. Reports will
be classified SECRET. The project monitor will be Dr extension

7. The requests approval or establishing a follow-on contract to Contract Task Order No. 2(62-9008)68R with-tha The work will cover a period of twelve months at a cost of approximately

APPROVED:

2 8 MAR 1959

Date

C00021917'

64

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