query: What is poliomyelitis?

title: Poliomyelitis

text: irritability. About one to five in 1000 cases progress to paralytic disease, in which the muscles become weak, floppy and poorly controlled, and, finally, completely paralyzed; this condition is known as acute flaccid paralysis. Depending on the site of paralysis, paralytic poliomyelitis is classified as spinal, bulbar, or bulbospinal. Encephalitis, an infection of the brain tissue itself, can occur in rare cases, and is usually restricted to infants. It is characterized by confusion, changes in mental status, headaches, fever, and, less commonly, seizures and spastic paralysis. Poliomyelitis is caused by infection with a member of the genus "Enterovirus" known as

title: Poliomyelitis

text: of the central nervous system. Infection or vaccination with one serotype of poliovirus does not provide immunity against the other serotypes, and full immunity requires exposure to each serotype. A rare condition with a similar presentation, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. Poliomyelitis is highly contagious via the fecal-oral (intestinal source) and the oral-oral (oropharyngeal source) routes. In endemic areas, wild polioviruses can infect virtually the entire human population. It is seasonal in temperate climates, with peak transmission occurring in summer and autumn. These seasonal differences are far less pronounced in tropical areas. The time between first

title: Poliomyelitis

text: Poliomyelitis Poliomyelitis, often called polio or infantile paralysis, is an infectious disease caused by the poliovirus. In about 0.5 percent of cases there is muscle weakness resulting in an inability to move. This can occur over a few hours to a few days. The weakness most often involves the legs but may less commonly involve the muscles of the head, neck and diaphragm. Many people fully recover. In those with muscle weakness about 2 to 5 percent of children and 15 to 30 percent of adults die. Another 25 percent of people have minor symptoms such as fever and a

title: Poliomyelitis

text: vaccine of choice for controlling poliomyelitis in many countries. On very rare occasions (about one case per 750,000 vaccine recipients), the attenuated virus in the oral polio vaccine reverts into a form that can paralyze. In 2017, cases caused by vaccine-derived poliovirus (cVDPV) outnumbered wild poliovirus cases for the first time, due to wild polio cases hitting record lows and relaxed vaccination levels. Most industrialized countries have switched to inactivated polio vaccine, which cannot revert, either as the sole vaccine against poliomyelitis or in combination with oral polio vaccine. There is no cure for polio. The focus of modern treatment

title: Poliomyelitis

text: derives from the Ancient Greek (), meaning "grey", ( “marrow”), referring to the grey matter of the spinal cord, and the suffix "-itis", which denotes inflammation, i.e., inflammation of the spinal cord’s grey matter, although a severe infection can extend into the brainstem and even higher structures, resulting in polio"encephal"itis, producing a lack of ability to breathe that requires mechanical assistance such as an iron lung. The Poliovirus Antivirals Initiative was launched in 2007 with the aim of developing antiviral medications for polio, but while several promising candidates were identified, none have progressed beyond Phase II clinical trials. Poliomyelitis Poliomyelitis,

title: History of poliomyelitis

text: his life and writing. The symptoms of poliomyelitis have been described by many names. In the early nineteenth century the disease was known variously as: Dental Paralysis, Infantile Spinal Paralysis, Essential Paralysis of Children, Regressive Paralysis, Myelitis of the Anterior Horns, Tephromyelitis (from the Greek "tephros", meaning "ash-gray") and Paralysis of the Morning. In 1789 the first clinical description of poliomyelitis was provided by the British physician Michael Underwood—he refers to polio as "a debility of the lower extremities". The first medical report on poliomyelitis was by Jakob Heine, in 1840; he called the disease "Lähmungszustände der unteren Extremitäten" ("Paralysis

title: Poliomyelitis eradication

text: Poliomyelitis eradication A public health effort to permanently eliminate all cases of poliomyelitis (polio) infection around the world began in 1988, led by the World Health Organization (WHO), the United Nations Children's Fund (UNICEF) and the Rotary Foundation. These organizations, along with the U.S. Centers for Disease Control and Prevention (CDC) and The Gates Foundation, have spearheaded the campaign through the Global Polio Eradication Initiative (GPEI), which helps to coordinate vaccination campaigns, environmental monitoring, evaluation of possible polio cases and logistics. Successful eradication of infectious diseases has been achieved twice before, with smallpox and rinderpest. Prevention of disease spread is

title: Poliomyelitis in Pakistan

text: function. Poliomyelitis in Pakistan Pakistan is one of the three remaining countries in the world where poliomyelitis (polio) is still categorized as an endemic viral infection, the others being Afghanistan and Nigeria. As of October 2015, there have been 38 documented cases of wild poliovirus in Pakistan in the past year. However, the disease is still present as of 2018. Though the polio immunization campaign in the country started in 1974, the efforts for eradication officially started in 1994. The infection remains endemic despite over 100 rounds of vaccination being carried out in the past decade. Pakistan had the world's

title: Poliomyelitis in Pakistan

text: Poliomyelitis in Pakistan Pakistan is one of the three remaining countries in the world where poliomyelitis (polio) is still categorized as an endemic viral infection, the others being Afghanistan and Nigeria. As of October 2015, there have been 38 documented cases of wild poliovirus in Pakistan in the past year. However, the disease is still present as of 2018. Though the polio immunization campaign in the country started in 1974, the efforts for eradication officially started in 1994. The infection remains endemic despite over 100 rounds of vaccination being carried out in the past decade. Pakistan had the world's highest

title: Poliomyelitis eradication

text: In Papua New Guinea, a strain of cVDPV1 has arisen that has caused twenty-six polio cases throughout the country. Response to the Syrian cVDPV2 outbreak continued into 2018, and virus transmission was successfully interrupted. Poliomyelitis eradication A public health effort to permanently eliminate all cases of poliomyelitis (polio) infection around the world began in 1988, led by the World Health Organization (WHO), the United Nations Children's Fund (UNICEF) and the Rotary Foundation. These organizations, along with the U.S. Centers for Disease Control and Prevention (CDC) and The Gates Foundation, have spearheaded the campaign through the Global Polio Eradication Initiative (GPEI),

title: Poliomyelitis eradication

text: removed from the bivalent oral vaccine, as was considered necessary with WPV2 due to its high risk of giving rise to cVDPV strains, but rather oral vaccination for WPV3 will continue until total eradication of polio allows all oral vaccination to cease. Following the widespread use of poliovirus vaccine in the mid-1950s, the incidence of poliomyelitis declined rapidly in many industrialized countries. Czechoslovakia became the first country in the world to scientifically demonstrate nationwide eradication of poliomyelitis in 1960. In 1962—just one year after Sabin's oral polio vaccine (OPV) was licensed in most industrialized countries—Cuba began using the oral vaccine

title: History of poliomyelitis

text: every year. The fear and the collective response to these epidemics would give rise to extraordinary public reaction and mobilization; spurring the development of new methods to prevent and treat the disease, and revolutionizing medical philanthropy. Although the development of two polio vaccines has eliminated poliomyelitis in all but three countries (Afghanistan, Pakistan and Nigeria), the legacy of poliomyelitis remains, in the development of modern rehabilitation therapy, and in the rise of disability rights movements worldwide. Ancient Egyptian paintings and carvings depict otherwise healthy people with withered limbs, and children walking with canes at a young age. It is theorized

title: History of poliomyelitis

text: world. The World Health Organization estimates that there are 10 to 20 million polio survivors worldwide. In 1977, the National Health Interview Survey reported that there were 254,000 people living in the United States who had been paralyzed by polio. According to local polio support groups and doctors, some 40,000 polio survivors with varying degrees of paralysis live in Germany, 30,000 in Japan, 24,000 in France, 16,000 in Australia, 12,000 in Canada and 12,000 in the United Kingdom. History of poliomyelitis The history of poliomyelitis (polio) infections extends into prehistory. Although major polio epidemics were unknown before the 20th century,

title: History of poliomyelitis

text: History of poliomyelitis The history of poliomyelitis (polio) infections extends into prehistory. Although major polio epidemics were unknown before the 20th century, the disease has caused paralysis and death for much of human history. Over millennia, polio survived quietly as an endemic pathogen until the 1900s when major epidemics began to occur in Europe; soon after, widespread epidemics appeared in the United States. By 1910, frequent epidemics became regular events throughout the developed world, primarily in cities during the summer months. At its peak in the 1940s and 1950s, polio would paralyze or kill over half a million people worldwide

title: Poliomyelitis

text: central nervous system (CNS), sometimes called abortive poliomyelitis, and a major illness involving the CNS, which may be paralytic or nonparalytic. In most people with a normal immune system, a poliovirus infection is asymptomatic. Rarely, the infection produces minor symptoms; these may include upper respiratory tract infection (sore throat and fever), gastrointestinal disturbances (nausea, vomiting, abdominal pain, constipation or, rarely, diarrhea), and influenza-like illness. The virus enters the central nervous system in about 1 percent of infections. Most patients with CNS involvement develop nonparalytic aseptic meningitis, with symptoms of headache, neck, back, abdominal and extremity pain, fever, vomiting, lethargy, and

title: Poliomyelitis

text: to occur in the late 19th century in Europe and the United States. In the 20th century it became one of the most worrying childhood diseases in these areas. The first polio vaccine was developed in the 1950s by Jonas Salk. In 2013 the World Health Organization hoped that vaccination efforts and early detection of cases would result in global eradication of the disease by 2018. The term "poliomyelitis" is used to identify the disease caused by any of the three serotypes of poliovirus. Two basic patterns of polio infection are described: a minor illness which does not involve the

title: Poliomyelitis

text: cases of wild polio and 5 cases of vaccine-derived polio. This is down from 350,000 wild cases in 1988. In 2014 the disease was only spreading between people in Afghanistan, Nigeria, and Pakistan. In 2015 Nigeria had stopped the spread of wild poliovirus but it reoccurred in 2016. Poliomyelitis has existed for thousands of years, with depictions of the disease in ancient art. The disease was first recognized as a distinct condition by the English physician Michael Underwood in 1789 and the virus that causes it was first identified in 1908 by the Austrian immunologist Karl Landsteiner. Major outbreaks started

title: Poliomyelitis

text: Warm Springs, Georgia, US. In 2008 four organizations (Rotary International, the World Health Organization, the U.S. Centers for Disease Control and UNICEF) were added to the Hall of Fame. World Polio Day (24 October) was established by Rotary International to commemorate the birth of Jonas Salk, who led the first team to develop a vaccine against poliomyelitis. Use of this inactivated poliovirus vaccine and subsequent widespread use of the oral poliovirus vaccine developed by Albert Sabin led to establishment of the Global Polio Eradication Initiative (GPEI) in 1988. Since then, GPEI has reduced polio worldwide by 99 percent. The term

title: Poliomyelitis

text: often credit the prolonged immobility and residual paralysis associated with polio as a driving force in their lives and careers. The disease was very well publicized during the polio epidemics of the 1950s, with extensive media coverage of any scientific advancements that might lead to a cure. Thus, the scientists working on polio became some of the most famous of the century. Fifteen scientists and two laymen who made important contributions to the knowledge and treatment of poliomyelitis are honored by the Polio Hall of Fame, which was dedicated in 1957 at the Roosevelt Warm Springs Institute for Rehabilitation in

title: Poliomyelitis

text: the late 19th and early 20th centuries, improvements were made in community sanitation, including better sewage disposal and clean water supplies. These changes drastically increased the proportion of children and adults at risk of paralytic polio infection, by reducing childhood exposure and immunity to the disease. Small localized paralytic polio epidemics began to appear in Europe and the United States around 1900. Outbreaks reached pandemic proportions in Europe, North America, Australia, and New Zealand during the first half of the 20th century. By 1950, the peak age incidence of paralytic poliomyelitis in the United States had shifted from infants to

title: Poliomyelitis

text: The last case of polio in the region was in India in January 2011. Since January 2011, there have been no reported cases of the wild polio infections in India, and in February 2012 the country was taken off the WHO list of polio endemic countries. It was reported that if there are no cases of wild polio in the country for two more years, it would be declared as a polio-free country. On 27 March 2014 the WHO announced the eradication of poliomyelitis in the South-East Asia Region, which includes eleven countries: Bangladesh, Bhutan, North Korea, India, Indonesia, Maldives,

title: Poliomyelitis

text: of poliovirus vaccine in the mid-1950s, the incidence of poliomyelitis declined dramatically in many industrialized countries. A global effort to eradicate polio began in 1988, led by the World Health Organization, UNICEF, and The Rotary Foundation. These efforts have reduced the number of annual diagnosed cases by 99.9 percent; from an estimated 350,000 cases in 1988 to a low of 483 cases in 2001, after which it remained at a level of about 1,000 – 2000 cases per year for a number of years. In 2015, cases decreased to 98 and further decreased in 2016 to 37 wild cases and

title: Poliomyelitis

text: purified the gamma globulin component of the blood plasma of polio survivors. Hammon proposed the gamma globulin, which contained antibodies to poliovirus, could be used to halt poliovirus infection, prevent disease, and reduce the severity of disease in other patients who had contracted polio. The results of a large clinical trial were promising; the gamma globulin was shown to be about 80 percent effective in preventing the development of paralytic poliomyelitis. It was also shown to reduce the severity of the disease in patients who developed polio. Due to the limited supply of blood plasma gamma globulin was later deemed

title: Poliomyelitis

text: vary depending on the serotype of the infecting poliovirus; the highest rates of paralysis (one in 200) are associated with poliovirus type 1, the lowest rates (one in 2,000) are associated with type 2. Spinal polio, the most common form of paralytic poliomyelitis, results from viral invasion of the motor neurons of the anterior horn cells, or the ventral (front) grey matter section in the spinal column, which are responsible for movement of the muscles, including those of the trunk, limbs, and the intercostal muscles. Virus invasion causes inflammation of the nerve cells, leading to damage or destruction of motor

title: Poliomyelitis

text: individual. In around 1 percent of infections, poliovirus spreads along certain nerve fiber pathways, preferentially replicating in and destroying motor neurons within the spinal cord, brain stem, or motor cortex. This leads to the development of paralytic poliomyelitis, the various forms of which (spinal, bulbar, and bulbospinal) vary only with the amount of neuronal damage and inflammation that occurs, and the region of the CNS affected. The destruction of neuronal cells produces lesions within the spinal ganglia; these may also occur in the reticular formation, vestibular nuclei, cerebellar vermis, and deep cerebellar nuclei. Inflammation associated with nerve cell destruction often

title: Poliomyelitis

text: closed in affected areas during poliomyelitis epidemics. Poliovirus enters the body through the mouth, infecting the first cells with which it comes in contact – the pharynx and intestinal mucosa. It gains entry by binding to an immunoglobulin-like receptor, known as the poliovirus receptor or CD155, on the cell membrane. The virus then hijacks the host cell's own machinery, and begins to replicate. Poliovirus divides within gastrointestinal cells for about a week, from where it spreads to the tonsils (specifically the follicular dendritic cells residing within the tonsilar germinal centers), the intestinal lymphoid tissue including the M cells of Peyer's

title: Poliomyelitis eradication

text: all wild-virus cases since that date being due to type 1 (WPV1). All three types are represented among the periodic cases arising from mutated oral vaccine strains, so-called circulating vaccine-derived poliovirus (cVDPV). India is the latest country to have officially stopped endemic transmission of polio, with its last reported case in 2011. Three countries remain where the disease is endemic—Afghanistan, Pakistan and Nigeria. Eradication of polio has been defined in various ways—as elimination of the occurrence of poliomyelitis even in the absence of human intervention, as extinction of poliovirus, such that the infectious agent no longer exists in nature or

title: Poliomyelitis eradication

text: India and Pakistan are not polio free", declared Health Minister ASM Matiur Rahman. (See: ) In 2007 there were 1,315 cases of poliomyelitis reported worldwide. Over 60% of cases (874) occurred in India; while in Nigeria, the number of polio cases fell dramatically, from 1,122 cases reported in 2006 to 285 cases in 2007. Officials credit the drop in new infections to improved political control in the southern states and resumed immunisation in the north, where Muslim clerics led a boycott of vaccination in late 2003. Local governments and clerics allowed vaccinations to resume on the condition that the vaccines

title: Poliomyelitis eradication

text: Polio Eradication Initiative, with the goal of eradicating polio by the year 2000. The initiative was inspired by Rotary International's 1985 pledge to raise $120 million toward immunising all of the world's children against the disease. The last case of wild poliovirus poliomyelitis in the Americas was reported in Peru, August 1991. On 20 August 1994 the Americas were certified as polio-free. This achievement was a milestone in efforts to eradicate the disease. In 1994 the Indian Government launched the Pulse Polio Campaign to eliminate polio. The current campaign involves annual vaccination of all children under age five. In 1995

title: Poliomyelitis eradication

text: may need to be longer for a strain like WPV3, where a lower proportion of those infected demonstrate symptoms, or if sewer samples stay positive. Wild poliovirus type 2 was certified eradicated in 2015, the last case having been detected in 1999. Wild poliovirus type 3 has not been detected since 2012, but its eradication has yet to be certified, and the Global Commission for the Certification of Poliomyelitis Eradication in 2017 recommended not certifying its eradication independent of that of WPV1, and hence of wild poliovirus as a whole. This recommendation would mean that type WPV3 will not be

title: Poliomyelitis eradication

text: together, these advantages have made it the preferred vaccine of many countries, and it has long been preferred by the global eradication initiative. The primary disadvantage of the OPV derives from its inherent nature as an attenuated but active virus. It can induce vaccine-associated paralytic poliomyelitis (VAPP) in approximately 1 individual per every 2.4 million doses administered. Likewise, mutation during the course of persistent circulation in undervaccinated populations can lead to vaccine-derived poliovirus strains (cVDPV) that can induce polio at much higher rates. Until recently, a trivalent OPV containing all three virus strains was used, but with the eradication of

title: Poliomyelitis eradication

text: in the laboratory, as control of an infection to the point at which transmission of the disease ceased within a specified area, and as reduction of the worldwide incidence of poliomyelitis to zero as a result of deliberate efforts, and requiring no further control measures. In theory, if the right tools were available, it would be possible to eradicate all infectious diseases that reside only in a human host. In reality there are distinct biological features of the organisms and technical factors of dealing with them that make their potential eradicability more or less likely. Three indicators, however, are considered

title: History of poliomyelitis

text: unaffected muscle fibers and promote the neuroplastic recruitment of remaining nerve cells that had not been killed by the virus. Sister Kenny later settled in Minnesota where she established the Sister Kenny Rehabilitation Institute, beginning a world-wide crusade to advocate her system of treatment. Slowly, Kenny's ideas won acceptance, and by the mid-20th century had become the hallmark for the treatment of paralytic polio. In combination with antispasmodic medications to reduce muscular contractions, Kenny's therapy is still used in the treatment of paralytic poliomyelitis. In 2009 as part of the Q150 celebrations, the Kenny regimen for polio treatment was announced

title: Poliomyelitis eradication

text: 2013, the WHO announced a new $5.5 billion, 6-year cooperative plan (called the 2013–18 Polio Eradication and Endgame Strategic Plan) to eradicate polio from its last reservoirs. The plan called for mass immunization campaigns in the three remaining endemic countries, and also dictated a switch to inactivated virus injections, to avoid the risk of the vaccine-derived outbreaks that occasionally occur from use of the live-virus oral vaccine. In 2014, there were 359 reported cases of wild poliomyelitis, spread over twelve countries. Pakistan had the most with 306, an increase from 93 in 2013, which was blamed on Al Qaeda and

title: History of poliomyelitis

text: innovations. One of the most widespread was the proliferation of "no spitting" ordinances in the United States and elsewhere. In 1921 Franklin D. Roosevelt became totally and permanently paralyzed from the waist down. Although the paralysis (whether from poliomyelitis, as diagnosed at the time, or from Guillain–Barré syndrome) had no cure at the time, Roosevelt, who had planned a life in politics, refused to accept the limitations of his disease. He tried a wide range of therapies, including hydrotherapy in Warm Springs, Georgia (see below). In 1938 Roosevelt helped to found the National Foundation for Infantile Paralysis (now known as

title: History of poliomyelitis

text: second wave of mass immunizations led to a further decline in the number of cases: by 1961, only 161 cases were recorded in the United States. The last cases of paralytic poliomyelitis caused by endemic transmission of poliovirus in the United States were in 1979, when an outbreak occurred among the Amish in several Midwestern states. Early in the twentieth century polio became the world's most feared disease. The disease hit without warning, tended to strike white, affluent individuals, required long quarantine periods during which parents were separated from children: it was impossible to tell who would get the disease

title: History of poliomyelitis

text: Between September 1951 and July 1952 nearly 55,000 children were involved in a clinical trial of the anti-polio serum. The results of the trial were promising; the serum was shown to be about 80% effective in preventing the development of paralytic poliomyelitis, and protection was shown to last for 5 weeks if given under tightly controlled circumstances. The serum was also shown to reduce the severity of the disease in patients who developed polio. The large-scale use of antibody serum to prevent and treat polio had a number of drawbacks, however, including the observation that the immunity provided by the

title: History of poliomyelitis

text: early 20th century—in the absence of proven treatments—a number of odd and potentially dangerous polio treatments were suggested. In John Haven Emerson's "A Monograph on the Epidemic of Poliomyelitis (Infantile Paralysis) in New York City in 1916" one suggested remedy reads: Following the 1916 epidemics and having experienced little success in treating polio patients, researchers set out to find new and better treatments for the disease. Between 1917 and the early 1950s several therapies were explored in an effort to prevent deformities including hydrotherapy and electrotherapy. In 1935 Claus Jungeblut reported that vitamin C treatment inactivates the polio virus in

title: History of poliomyelitis

text: the disease. In developed countries during the late 19th and early 20th centuries, improvements were being made in community sanitation, including improved sewage disposal and clean water supplies. Better hygiene meant that infants and young children had fewer opportunities to encounter and develop immunity to polio. Exposure to poliovirus was therefore delayed until late childhood or adult life, when it was more likely to take the paralytic form. In children, paralysis due to polio occurs in one in 1000 cases, while in adults, paralysis occurs in one in 75 cases. By 1950, the peak age incidence of paralytic poliomyelitis in

title: History of poliomyelitis

text: occurred the following year in Vermont with 132 total cases (18 deaths), including several cases in adults. Numerous epidemics of varying magnitude began to appear throughout the country; by 1907 approximately 2,500 cases of poliomyelitis were reported in New York City. On Saturday, June 17, 1916, an official announcement of the existence of an epidemic polio infection was made in Brooklyn, New York. That year, there were over 27,000 cases and more than 6,000 deaths due to polio in the United States, with over 2,000 deaths in New York City alone. The names and addresses of individuals with confirmed polio

title: History of poliomyelitis

text: of the lower Extremities"). Karl Oskar Medin was the first to empirically study a poliomyelitis epidemic in 1890. This work, and the prior classification by Heine, led to the disease being known as "Heine-Medin disease". Major polio epidemics were unknown before the 20th century; localized paralytic polio epidemics began to appear in Europe and the United States around 1900. The first report of multiple polio cases was published in 1843 and described an 1841 outbreak in Louisiana. A fifty-year gap occurs before the next U.S. report—a cluster of 26 cases in Boston in 1893. The first recognized U.S. polio epidemic

title: Poliomyelitis

text: 2 to 5 percent of children and up to 15 to 30 percent of adults die. Bulbar polio often causes death if respiratory support is not provided; with support, its CFR ranges from 25 to 75 percent, depending on the age of the patient. When intermittent positive pressure ventilation is available, the fatalities can be reduced to 15 percent. Many cases of poliomyelitis result in only temporary paralysis. Nerve impulses return to the formerly paralyzed muscle within a month, and recovery is usually complete in six to eight months. The neurophysiological processes involved in recovery following acute paralytic poliomyelitis are

title: Poliomyelitis eradication

text: Taliban militants preventing aid workers from vaccinating children in rural regions of the country. On 27 March 2014, the WHO announced the eradication of poliomyelitis in the South-East Asia Region, in which the WHO includes eleven countries: Bangladesh, Bhutan, North Korea, India, Indonesia, Maldives, Myanmar, Nepal, Sri Lanka, Thailand and Timor-Leste. With the addition of this region, the proportion of world population living in polio-free regions reached 80%. The last case of wild polio in the South-East Asia Region was reported in India on 13 January 2011. During 2015, 74 cases of wild poliomyelitis were reported worldwide, 54 in Pakistan

title: Poliomyelitis

text: onset. Half the patients with spinal polio recover fully; one-quarter recover with mild disability, and the remaining quarter are left with severe disability. The degree of both acute paralysis and residual paralysis is likely to be proportional to the degree of viremia, and inversely proportional to the degree of immunity. Spinal polio is rarely fatal. Without respiratory support, consequences of poliomyelitis with respiratory involvement include suffocation or pneumonia from aspiration of secretions. Overall, 5 to 10 percent of patients with paralytic polio die due to the paralysis of muscles used for breathing. The case fatality rate (CFR) varies by age:

title: Poliomyelitis

text: of the diaphragm occurs. The critical nerves affected are the phrenic nerve (which drives the diaphragm to inflate the lungs) and those that drive the muscles needed for swallowing. By destroying these nerves, this form of polio affects breathing, making it difficult or impossible for the patient to breathe without the support of a ventilator. It can lead to paralysis of the arms and legs and may also affect swallowing and heart functions. Paralytic poliomyelitis may be clinically suspected in individuals experiencing acute onset of flaccid paralysis in one or more limbs with decreased or absent tendon reflexes in the

title: History of poliomyelitis

text: that the Roman Emperor Claudius was stricken as a child, and this caused him to walk with a limp for the rest of his life. Perhaps the earliest recorded case of poliomyelitis is that of Sir Walter Scott. In 1773 Scott was said to have developed "a severe teething fever which deprived him of the power of his right leg". At the time, polio was not known to medicine. A retrospective diagnosis of polio is considered to be strong due to the detailed account Scott later made, and the resultant lameness of his right leg had an important effect on

title: What Is the What

text: What Is the What What Is the What: The Autobiography of Valentino Achak Deng is a 2006 novel written by Dave Eggers. It is based on the life of Valentino Achak Deng, a Sudanese child refugee who immigrated to the United States under the Lost Boys of Sudan program. It was a finalist for the National Book Award. As a boy, Achak is separated from his family during the Second Sudanese Civil War when the Arab militia, referred to as "murahaleen" (which is Arabic for the deported), wipes out his Dinka village, Marial Bai. During the assault, he loses sight

title: What Is the What

text: That Happens Will Happen Today". Tom Tykwer plans to adapt the novel into a film. In 2009, the novel received the Prix Médicis étranger in France. What Is the What What Is the What: The Autobiography of Valentino Achak Deng is a 2006 novel written by Dave Eggers. It is based on the life of Valentino Achak Deng, a Sudanese child refugee who immigrated to the United States under the Lost Boys of Sudan program. It was a finalist for the National Book Award. As a boy, Achak is separated from his family during the Second Sudanese Civil War when

title: Here Is What Is

text: Here Is What Is Here Is What Is is the fifth studio album by Canadian songwriter and record producer Daniel Lanois. It was first released in December 2007 as a high-quality download, and later released on CD on March 18, 2008. The album is the result of the same project that led to the 2007 documentary "Here Is What Is" that premiered at the 2007 Toronto International Film Festival in September. The movie documents the aesthetics and creative process behind Lanois' approach to music making and recording. The album has been presented as a direct soundtrack to this film, and

title: Poliomyelitis in Pakistan

text: the Taliban, who forward claims that the vaccination campaigns are a facade for intelligence gathering. The fake Hepatitis B campaign has caused people to question the motivations behind all vaccination campaigns, leading to a spike in poliomyelitis cases from 198 in 2011 to 306 cases in 2014. Many citizens of both the US and various other nations have criticized the CIA's vaccination campaign for the effects that it has had on Pakistan's public health. In 2015, the Khyber Pakhtunkhwa government issued arrest warrants for 1,200 parents and guardians for refusing to administer vaccine to their children. 512 people were arrested

title: (What Is) Love?

text: (What Is) Love? "(What Is) Love?" is a song recorded by American entertainer Jennifer Lopez. Originally entitled "What Is Love?", the song appeared on the soundtrack to "The Back-up Plan" (2010), a film in which Lopez stars. The song was later included on Lopez's seventh studio album "Love?" (2011), as the album's title track. "(What Is) Love?" is a midtempo electropop song written by Diana "Wynter" Gordon, with the song's producer Emile "D'Mile" Dernst II. The song is about "not knowing what love is," according to Gordon. A remix of "(What Is) Love?", entitled "What Is Love? Part II", was

title: Here Is What Is

text: some of the tracks ("Beauty" and "Chest of Drawers") are conversations with Brian Eno. All songs written by Daniel Lanois unless otherwise noted. "Where Will I Be" is a new version of a song which had been previously released on Emmylou Harris' album "Wrecking Ball" in 1995. "Lovechild" and "Sacred And Secular" tracks incorporates, respectively, the pedal steel guitar melody used in "Carla", on Belladonna album, and the pedal steel guitar melody used in "Transmitter", on Shine album. Here Is What Is Here Is What Is is the fifth studio album by Canadian songwriter and record producer Daniel Lanois. It

title: What Is the What

text: writes: "Over the course of many years, Dave and I have collaborated to tell my story... I told [him] what I knew and what I could remember, and from that material he created this work of art." The book is typical of Eggers' style: blending non-fictional and fictional elements into a non-fiction novel or memoir. By classifying the book a novel, Eggers says, he freed himself to re-create conversations, streamline complex relationships, add relevant detail and manipulate time and space in helpful ways—all while maintaining the essential truthfulness of the storytelling. However, not all critics were impressed. Lee Siegel sees

title: What is Living and What is Dead in Indian Philosophy

text: What is Living and What is Dead in Indian Philosophy What is Living and What is Dead in Indian Philosophy is a 1976 book by Debiprasad Chattopadhyaya. Explaining the relationship between the soul and consciousness in the Nyaya-Vaisesika philosophy, Debiprasad Chattopadhyaya makes three points. First, consciousness in this view is knowledge (jnana) in an empirical sense. Second, consciousness is one of the multiple qualities of the soul. Third, consciousness is a transient quality, not a permanent quality. By itself, the soul is without consciousness; consciousness is produced in the soul only when it is conjoined with certain other entities. Hiriyanna,

title: What Is Life

text: of "What Is Life" on his 2005 tribute CD "Something for George". "What Is Life" was performed live at George Fest 2014 by "Weird Al" Yankovic. The recording is available on YouTube. The following musicians are believed to have played on "What Is Life": What Is Life "What Is Life" is a song by the English musician George Harrison, released on his 1970 triple album "All Things Must Pass". In many countries, it was issued as the second single from the album, in February 1971, becoming a top-ten hit in the United States, Canada and elsewhere, and topping singles charts

title: This Is What You Want... This Is What You Get

text: in the film. The album was seen as a step down from the band's efforts. Pitchfork Media named the album "maligned but salvageable". Allmusic said the album as "the most tentative and least powerful of PiL's recordings." This Is What You Want... This Is What You Get This Is What You Want... This Is What You Get is a 1984 album by Public Image Ltd. It is the band's fourth official studio album and includes the single "Bad Life" and a re-recorded version of a "This Is Not a Love Song", which had been a No. 5 UK and international

text: This Is What You Want... This Is What You Get This Is What You Want... This Is What You Get is a 1984 album by Public Image Ltd. It is the band's fourth official studio album and includes the single "Bad Life" and a re-recorded version of a "This Is Not a Love Song", which had been a No. 5 UK and international hit when released as a single in 1983. An early version of the album was released in 1983 by founding PiL guitarist Keith Levene as "Commercial Zone". The album was then re-recorded after Levene's departure from the

text: commenting on this point, notes: Hiriyanna expresses his perplexity in reviewing the Nyaya-Vaisesika view of consciousness, and then comes out with a comment equating this view with the Charvaka view of consciousness: What is Living and What is Dead in Indian Philosophy What is Living and What is Dead in Indian Philosophy is a 1976 book by Debiprasad Chattopadhyaya. Explaining the relationship between the soul and consciousness in the Nyaya-Vaisesika philosophy, Debiprasad Chattopadhyaya makes three points. First, consciousness in this view is knowledge (jnana) in an empirical sense. Second, consciousness is one of the multiple qualities of the soul. Third,

title: What Is History?

text: and were instead products of their own places and times, which in turn decided what "facts of the past" they determined into "facts of history". British historian Richard J. Evans said "What Is History?" caused a revolution in British historiography in the 1960s. Australian historian Keith Windschuttle, a critic of Carr, said "What Is History?" is one of the most influential books written about historiography, and that very few historians working in the English language since the 1960s had not read it. What Is History? What Is History? is a study that was written by the English historian E. H.

title: What Is Art?

text: in Tolstoy and his problems: essays. London: Grant Richards. pp. 66–101. Maude, Aylmer (1901b). “"What is Art?" - Tolstoy’s Theory of Art”, in Tolstoy and his problems: essays. London: Grant Richards. pp. 102–127. Noyes, George (1918). Tolstoy. London: Duffield. Pevear, Richard (1995). "Preface" in Tolstoy, Leo (1995 [1897]). "What is Art?" (Translated by Richard Pevear and Larissa Volokhonsky). London: Penguin. Simmons, Ernest (1973). "What is Art?", in Tolstoy. London: Routledge and Kegan Paul. pp. 175–189. What Is Art? What is Art? ( "Chto takoye iskusstvo?") is a book by Leo Tolstoy. It was completed in Russian in 1897 but first

text: He then flew over to London and presented them to Richard Branson as the finished new PiL album for Virgin Records: "Commercial Zone". For his part, John Lydon decided to completely abandon the tapes and re-record the whole album from scratch with session musicians. This new version of "Commercial Zone" became "This Is What You Want... This Is What You Get" in 1984. "The Order of Death" is a reference to the film "Copkiller", also known as "The Order of Death". The line "This is what you want... This is what you get", which gives title to the album, appears

text: were not re-recorded for "This Is What You Want...This Is What You Get" (although a remixed version of "Blue Water" was included as the B-side on the "This Is Not a Love Song" 12" single). Songs on "This Is What You Want...This Is What You Get" which did not appear in any form on "Commercial Zone" are "Tie Me to the Length of That", "The Pardon" and "1981", and are the only songs on the album which do not credit Keith Levene as a co-writer. PiL was supposed to score the soundtrack for the 1983 suspense film "Copkiller", starring Harvey

title: What Is Love

text: What Is Love "What Is Love" is a song recorded by Trinidadian-German Eurodance artist Haddaway for his debut album, "The Album". The song is recognizable by its refrain "What is love? Baby don't hurt me, don't hurt me... no more." It was a massive hit in Europe, becoming a number-one hit in at least 13 countries and reaching number two in Germany, Sweden, and the United Kingdom. Outside Europe, the song was moderately successful, reaching number 11 in the United States, number 12 in Australia, number 17 in Canada, and number 48 in New Zealand. "What Is Love" was written

title: What Is Art?

text: What Is Art? What is Art? ( "Chto takoye iskusstvo?") is a book by Leo Tolstoy. It was completed in Russian in 1897 but first published in English due to difficulties with the Russian censors. Tolstoy cites the time, effort, public funds, and public respect spent on art and artists as well as the imprecision of general opinions on art as reason for writing the book. In his words, "it is difficult to say what is meant by art, and especially what is good, useful art, art for the sake of which we might condone such sacrifices as are being

title: (What Is) Love?

text: she was dissatisfied with the circumstances, but was in "no way dissing Lopez." A mastered version of "What Is Love?" was included on the soundtrack to "The Back-up Plan" (2010), a film in which Lopez stars. "What Is Love?" was re-titled as "(What Is) Love?" and appeared on "Love?" (2011). "(What Is) Love?" was due to be released as a promotional single from "Love?" on April 26, 2011, but was "unlocked" and released four days earlier, on April 22, 2011 by through a campaign on Lopez's Facebook page. It was released in many European countries on April 25. The song

title: What You Get Is What You See

text: What You Get Is What You See "What You Get Is What You See" is a song by recording artist Tina Turner from her album "Break Every Rule" (1986). The song was written by the Terry Britten and Graham Lyle team and was notably different from the three previous singles that they had written for Turner, "What's Love Got to Do with It", "We Don't Need Another Hero" and "Two People", as it was an up-tempo country-tinged rock track featuring Eric Clapton on guitars. Tina Turner said in an interview that "What You Get Is What You See" is her

title: What Is and What Should Never Be

text: What Is and What Should Never Be "What Is and What Should Never Be" is a song by English rock band Led Zeppelin. It was written by Jimmy Page and Robert Plant and was included as the second track on "Led Zeppelin II" (1969). "What is and What Should Never Be" was one of the first songs on which Page used his soon-to-become trademark Gibson Les Paul for recording. The production makes liberal use of stereo as the guitars pan back and forth between channels. Robert Plant's vocals were phased during the verses. Record producer Rick Rubin has remarked, "The

title: What Is Love

text: An official music video was released directed by Soulvizion. It features the Dutch professional basketball player Don Rigters who plays the role of David Rose, a basketball player who is severely injured trying to make a comeback to the game with encouragement from his girlfriend, (played by Melissa Kanza), his three teammates, (Alkenah Wansing, Jeroen Jansen and Lindy Chippendel) and by his basketball coach (played by J E Rigters). What Is Love "What Is Love" is a song recorded by Trinidadian-German Eurodance artist Haddaway for his debut album, "The Album". The song is recognizable by its refrain "What is love?

title: What Is It?

text: What Is It? What Is It? is a 2005 American surrealist film written, edited, co-produced and directed by Crispin Glover. It stars Crispin Glover and Fairuza Balk and Steven C. Stewart. As of 2008, the film has only been shown at independent theaters, typically accompanied by a question-and-answer session, a one-hour dramatic narration of eight different profusely illustrated books as a slideshow, and a meet-and-greet/book signing with Glover. "What Is It?" is the first entry in a planned trilogy directed by Glover, followed by "It Is Fine! Everything Is Fine." and continued with "It Is Mine". The "adventures" of a

title: What Is Literature?

text: The art of writing is deeply linked to freedom and thus ventures into the fields of politics and democracy. The poet frees himself by disassociation, and the prose writer fulfills a duty to utilize language for the end of a conceived free society. What Is Literature? What Is Literature? (), also published as "Literature and Existentialism",) is an essay by French philosopher and novelist Jean-Paul Sartre, published by Gallimard in 1948. Initially published in freestanding essays across French literary journals "Les Temps modernes", "Situations I" and "Situations II", essays "What is Writing?" and "Why Write?" were translated into English and

title: What Work Is

text: terribly damaged conditions of American labor, whose circumstance has perhaps never been more wrecked.” After Levine was named Poet Laureate, "What Work Is" reached the top of Amazon.com's "Movers and Shakers" list. What Work Is What Work Is is a collection of poetry by Philip Levine. The collection has many themes that are representative of Levine's writing including physical labor, class identity, family relationships and personal loss. Its primary focus on work and the working class led to it being studied with emphasis on Marxist literary criticism. The focus on work is expressed in thematically different ways throughout the collection.

title: What Work Is

text: What Work Is What Work Is is a collection of poetry by Philip Levine. The collection has many themes that are representative of Levine's writing including physical labor, class identity, family relationships and personal loss. Its primary focus on work and the working class led to it being studied with emphasis on Marxist literary criticism. The focus on work is expressed in thematically different ways throughout the collection. Furthermore, much of the collection was shaped by concerns for blue collar workers as well as nationwide political events. "What Work Is" was first published in 1991 by Alfred A. Knopf, Inc.

title: What Is and What Should Never Be

text: and What Should Never Be" was performed live at Led Zeppelin concerts between 1969 and 1973. A live version taken from a performance at the Royal Albert Hall in 1970 can be seen on the "Led Zeppelin DVD". Another was included on disc two of the live triple album "How The West Was Won". Two more versions were included in BBC Sessions. What Is and What Should Never Be "What Is and What Should Never Be" is a song by English rock band Led Zeppelin. It was written by Jimmy Page and Robert Plant and was included as the second

title: What Is Life

text: What Is Life "What Is Life" is a song by the English musician George Harrison, released on his 1970 triple album "All Things Must Pass". In many countries, it was issued as the second single from the album, in February 1971, becoming a top-ten hit in the United States, Canada and elsewhere, and topping singles charts in Australia and Switzerland. In the United Kingdom, "What Is Life" appeared as the B-side to "My Sweet Lord", which was the best-selling single there of 1971. Harrison's backing musicians on the song include Eric Clapton and the entire Delaney & Bonnie Friends band,

title: What Is Love

text: in "Just Dance 2017". In 2009, German DJ Klaas remixed the song under the title "Klaas meets Haddaway – What Is Love 2K9". This remix charted in several European countries. In 2016, Belgian DJ Lost Frequencies released a cover titled "What Is Love 2016", as a single from his debut album "Less Is More". It was actually already produced back in 2014 as a remix for Jaymes Young's cover version of "What is Love". This version was remade for the album and became a hit on a number of European singles charts and topped the Belgian Ultratop Official Singles Chart.

title: What Is Literature?

text: What Is Literature? What Is Literature? (), also published as "Literature and Existentialism",) is an essay by French philosopher and novelist Jean-Paul Sartre, published by Gallimard in 1948. Initially published in freestanding essays across French literary journals "Les Temps modernes", "Situations I" and "Situations II", essays "What is Writing?" and "Why Write?" were translated into English and published by the Paris-based literary journal Transition 1948. The English translation by Bernard Frechtman was published in 1950. Sartre attempts to devise an understanding of the effect literature has on those who are subjected to it. In the foreword Sartre addresses his critics

title: (What Is) Love?

text: the internet on April 20, 2013. According to Jessica Sager of PopCrush, it picks up where the original song left off. Sager wrote that the song "likely isn't about [Marc] Anthony — but for those new to the song, it's surely easy to interpret it as such. Lopez gets pretty revealing in the new song, addressing a divorce directly and explicitly". Credits adapted from the liner notes of "Love?". (What Is) Love? "(What Is) Love?" is a song recorded by American entertainer Jennifer Lopez. Originally entitled "What Is Love?", the song appeared on the soundtrack to "The Back-up Plan" (2010),

title: The World Is What It Is

text: The World Is What It Is The World Is What It Is: The Authorized Biography of V. S. Naipaul is a biography of the Nobel Prize-winning author V. S. Naipaul by Patrick French. It was published in 2008 (by Picador in the UK and Knopf in the USA). The title is a quotation from Naipaul's book "A Bend in the River". "The world is what it is; men who are nothing, who allow themselves to become nothing, have no place in it." French deals with Naipaul's family background and his life from his birth in 1932 until his second marriage

title: What Is Life

text: in the UK as perhaps the strongest of all of Harrison's singles. Writing in 1981, "NME" critic Bob Woffinden grouped "What Is LIfe" with "My Sweet Lord", "Isn't It a Pity" and "Awaiting on You All" as "all excellent songs". Reviewing the 2001 reissue of "All Things Must Pass", for "Rolling Stone", James Hunter wrote of how the album's music "exults in breezy rhythms", among which "the colorful revolutions of 'What Is Life' ... [move] like a Ferris wheel". The following year, in Rolling Stone Press's "Harrison" tribute book, David Fricke included "What Is Life" among his selection of "essential

title: What Is Life

text: love song – perhaps a "lovingly crafted paen" to Harrison's wife Pattie, as Alan Clayson puts it – or a devotional song like many of Harrison's compositions. Ian Inglis writes that the song title suggests a "philosophical debate about the meaning of life", yet its rendering as ""what is my life"" in the choruses "reshapes [the meaning] completely". Theologian Dale Allison finds no religious content in "What Is Life" but notes the "failure of words to express feelings" implied in the opening line (""What I feel, I can't say""), a recurring theme of Harrison's spiritual songs such as "That Is

title: What Is This?

text: project while the former was seen as side endeavor. What Is This released their debut EP "Squeezed" in 1984. Around this time, Hillel Slovak had become uncertain of his role in the band and decided to rejoin the Red Hot Chili Peppers. He left What Is This in 1985, and later that year the band would release its only full-length studio album "What Is This?" and its final EP "3 Out of 5 Live". After this, the band broke up. Alain Johannes later met Natasha Shneider and the duo formed Walk The Moon, whose sole studio album featured Jack Irons

title: What Is This?

text: following week. The group decided to change their name to the Red Hot Chili Peppers, played several more shows at various L.A. clubs and musical venues, and eventually recorded a demo tape, all while Slovak and Irons were still playing with What Is This?. A few months later, What Is This received a record deal with MCA Records and the Red Hot Chili Peppers received a joint deal with EMI America and Enigma Records. Hillel Slovak and Jack Irons decided to leave the Red Hot Chili Peppers and stay with What Is This? as the latter was their primary musical

title: What Is This?

text: What Is This? What Is This (known prior to 1980 as Anthym) was a rock band that originated in Fairfax High School in California and would play numerous shows along the coast of California. It was formed by guitarist Hillel Slovak, drummer Jack Irons, vocalist Alain Johannes, and bassist Todd Strassman. Originally named Chain Reaction, the band would later change its name to Anthem, then later to Anthym (as there was already a band using the former moniker), and then finally to What Is This, which was a tongue-in-cheek reference to the reaction they usually received from first-time listeners. During

title: What Is Art?

text: Aylmer Maude, translator of many of Tolstoy's writings, calls it "probably the most masterly of all Tolstoy's works", citing the difficulty of the subject matter and its clarity. For a comprehensive review of the reception at the time of publication, see Maude 1901"b". Bayley, John (1986 [1966]). ""What is Art?" - excerpt from Tolstoy and the Novel" in Bloom, Harold (ed.). Leo Tolstoy. New York: Chelsea House. p. 141-152. Jahn, Gary R. (1975). "The aesthetic theory of Leo Tolstoy's "What is Art?"". "Journal of Aesthetics and Art Criticism" 34 (1): 59-65. Maude, Aylmer (1901a). “"What is Art?" - An Introduction”,

title: (What Is) Love?

text: song. Lopez's vocals for the song were recorded and produced by Kuk Harrell, with recording assistance from Jim Annunziato and Josh Gudwin at Conway Studios in Hollywood, California. Annunziato and Eric Eylands handled audio engineering of "(What Is) Love?", while the song was later mixed by Mike "Handz" Donaldson at Chalice Recording Studios in Los Angeles, California. "(What Is) Love?" deals with the topic of "not knowing what love is". The song's co-writer Gordon stated that: "I felt like so many woman have that same story. No fathers, families, abusive boyfriends and husbands..no parental support, they feel alone .. I've

title: What Is Intelligence?

text: What Is Intelligence? What Is Intelligence?: Beyond the Flynn Effect is a book by psychologist James R. Flynn which outlines his model for an explanation of the eponymous Flynn effect. The book summarizes much of the work of Flynn in this area, as well as that of his colleague William Dickens of the Brookings Institution. The book begins with a description of what has generally become known as "the Flynn effect": the steady rise from one generation to the next in average scores on IQ tests over time. Flynn notes that this effect apparently contradicts some fundamental beliefs about IQ

title: What U See Is What U Get

text: What U See Is What U Get "What U See Is What U Get" is the first single from Xzibit's second album, "40 Dayz & 40 Nightz". In its first week the song peaked at #50 on the "Billboard" Hot 100, being Xzibit's highest charting single. It peaked at #3 on Hot Rap Singles, his highest on that chart. A music video directed by Gregory Dark was filmed in Los Angeles. The deceptively simplistic premise of the video is Xzibit's trek to a nearby shop after being asked to pick up some milk. On his way, Xzibit greets several friends,

title: What Is Life

text: All", "Mystical One" and "Pisces Fish". Joshua Greene, another religious academic, identifies the song as part of its parent album's "intimately detailed account of a spiritual journey": where "Awaiting on You All" shows Harrison "convinced of his union with God", "What Is Life" reveals him to be "uncertain that he deserved such divine favor". The song's second verse repeats what Inglis refers to as the "somewhat confusing promise" from Harrison (in lines 3 and 4) should his love be "rejected": Musically, Simon Leng describes "What Is Life" as "Motown-spiced" and a comparatively rare example of its composer's willingness to embrace

title: What You Get Is What You See

text: where in 1989 it was used in a campaign for the New South Wales Rugby League. They later used the Tina Turner song "The Best" in another campaign. The song has been covered many times including by Canadian country music group Straight Clean & Simple and a single for the band taken from their 1992 album "Iron Lady". It was also covered by Scottish / Irish country artist Lisa McHugh. Her cover appears in her 2014 album "A Life That's Good". What You Get Is What You See "What You Get Is What You See" is a song by recording

title: What U See Is What U Get

text: the music videos for Xzibit's songs "Paparazzi" and "The Foundation". The music video peaked at 1 during 6 weeks at BET's "Rap City". 12" Promo What U See Is What U Get "What U See Is What U Get" is the first single from Xzibit's second album, "40 Dayz & 40 Nightz". In its first week the song peaked at #50 on the "Billboard" Hot 100, being Xzibit's highest charting single. It peaked at #3 on Hot Rap Singles, his highest on that chart. A music video directed by Gregory Dark was filmed in Los Angeles. The deceptively simplistic premise

title: What Is a Nation?

text: What Is a Nation? "What is a Nation?" ("Qu'est-ce qu'une nation?") is an 1882 lecture by French historian Ernest Renan (1823–1892), known for the statements that a nation is "a daily referendum", and that nations are based as much on what the people jointly forget, as what they remember. It is frequently quoted or anthologized in works of history or political science pertaining to nationalism and national identity. Renan wrote "What is a Nation" in order to symbolize the nationalism which was born in France as a result of the French Revolution of 1789. Renan begins his essay by noting

title: What Is History?

text: that historians deem unimportant, and "historical facts", information that the historians have decided is important. Carr contended that historians arbitrarily determine which of the "facts of the past" to turn into "historical facts" according to their own biases and agendas. For this reason, Carr argued that Leopold von Ranke's famous dictum "wie es eigentlich gewesen" (show what actually happened) was wrong because it presumed that the "facts" influenced what the historian wrote, rather than the historian choosing what "facts of the past" he or she intended to turn into "historical facts". At the same time, Carr argued that the study

text: songs by John Lydon, Keith Levene, and Martin Atkins except * by John Lydon and Martin Atkins Five songs on "This Is What You Want...This Is What You Get" are re-recordings of tracks which originally appeared on "Commercial Zone": "Bad Life" (originally titled "Mad Max"), "This Is Not a Love Song" (originally titled "Love Song"), "Solitaire" (entitled "Young Brits" on the second pressing of "Commercial Zone"), "The Order of Death" (originally titled "The Slab"), and "Where Are You?" (originally titled "Lou Reed Part 2"). Four songs from "Commercial Zone", "Bad Night", "Lou Reed Part 1", "Blue Water" and "Miller Hi-Life",

text: band, with no contributions from either Levene or bassist Pete Jones (who contributed to several tracks on "Commercial Zone"). The song "The Order of Death" appears in the 1990 science fiction-horror film "Hardware" and on the soundtrack to the 1999 horror film "The Blair Witch Project". It was also featured in the "Miami Vice" episode "Little Miss Dangerous" and the "Mr. Robot" episode "eps2.7_init_5.fve". "This is Not a Love Song" appears in the film "Waltz With Bashir". The line "This is what you want... This is what you get" appears in both "Bad Life" and "The Order of Death". All

title: What Is and What Should Never Be

text: descending riff [of "What Is and What Should Never Be"] is amazing: It's like a bow is being drawn back, and then it releases. The rhythm of the vocals is almost like a rap. It's insane — one of their most psychedelic songs." This was also one of the first songs recorded by the band for which Robert Plant received writing credit. According to rock journalist Stephen Davis, the author of the Led Zeppelin biography "Hammer of the Gods: The Led Zeppelin Saga", the lyrics for this song reflect a romance Plant had with his wife's younger sister. "What Is

title: What Is Spiritism?

text: What Is Spiritism? What Is Spiritism? ("Qu'Est-ce Que le Spiritisme" in French) is a brief introduction to Spiritism written by Allan Kardec in 1859, which is about a quarter of the length of The Spirits Book. Modern editions are augmented by a brief biography of the author, written by Henri Sausse, in 1896 which is mostly focused on his role in the History of Spiritism. The book is structured as a series of conferences about Spiritism, intended to quench the public curiosity and dismiss false notions about the doctrine. It is not intended as an initiation and is not seen

title: What Is Spiritism?

text: notably: This chapter introduces some new doctrine that would be further elaborated on The Gospel According to Spiritism. What Is Spiritism? What Is Spiritism? ("Qu'Est-ce Que le Spiritisme" in French) is a brief introduction to Spiritism written by Allan Kardec in 1859, which is about a quarter of the length of The Spirits Book. Modern editions are augmented by a brief biography of the author, written by Henri Sausse, in 1896 which is mostly focused on his role in the History of Spiritism. The book is structured as a series of conferences about Spiritism, intended to quench the public curiosity

title: What Is Life?

text: causing a net increase in disorder in the Universe. In order to increase the complexity on Earth—as life does—free energy is needed and in this case is provided by the Sun. What Is Life? What Is Life? The Physical Aspect of the Living Cell is a 1944 science book written for the lay reader by physicist Erwin Schrödinger. The book was based on a course of public lectures delivered by Schrödinger in February 1943, under the auspices of the Dublin Institute for Advanced Studies at Trinity College, Dublin. The lectures attracted an audience of about 400, who were warned "that

title: What Work Is

text: workers, but artists, readers, and academics. Levine's poetry is accessible and moving and is utterly American. The poems in "What Work Is" are more subtle in their thematic construction. Levine does not use caricatures in these poems but instead intimates real blue-collar workers. Many of the poems give a representation of a station of life not common in the subject matter of contemporary American poetry. Although not all of "What Work Is" is primarily about the working class. Instead the poems have a wide range and variety. However many of these poems, despite their subject matter, show elements that identify

title: What Is Love? (EP)

text: What Is Love? (EP) What Is Love? (stylized as What is Love?) is the fifth extended play (EP) by South Korean girl group Twice. The EP was released on April 9, 2018 by JYP Entertainment and is distributed by Iriver. It includes the lead single of the same name produced by Park Jin-young. Twice members Jeongyeon, Chaeyoung, and Jihyo also took part in writing lyrics for two songs on the EP. The reissue of "What Is Love?", titled "Summer Nights", was released on July 9, 2018. On February 26, 2018, JYP Entertainment confirmed that Twice planned to release a new