### Instruction: What University has most Heisman Trophy winners?
### Response: USC, The University of Southern California, has the most Heisman Trophy Winners: 1965 Mike Garrett, 1968 O. J. Simpson, 1979 Charles White, 1981 Marcus Allen, 2002 Carson Palmer, 2004 Matt Leinart, 2005, Reggie Bush, 2022 Caleb Williams. The Heisman Trophy is considered the most prestigious collegiate individual athletic award.