### Instruction: Highlight relevant facts related to Heidelberg
### Input: Heidelberg (German: [ˈhaɪdl̩bɛʁk] (listen); Palatine German: Heidlberg) is a city in the German state of Baden-Württemberg, situated on the river Neckar in south-west Germany. As of the 2016 census, its population was 159,914, of which roughly a quarter consisted of students.

Located about 78 km (48 mi) south of Frankfurt, Heidelberg is the fifth-largest city in Baden-Württemberg. Heidelberg is part of the densely populated Rhine-Neckar Metropolitan Region.

Heidelberg University, founded in 1386, is Germany's oldest and one of Europe's most reputable universities. Heidelberg is a scientific hub in Germany and home to several internationally renowned research facilities adjacent to its university, including the European Molecular Biology Laboratory and four Max Planck Institutes. The city has also been a hub for the arts, especially literature, throughout the centuries, and it was designated a "City of Literature" by the UNESCO Creative Cities Network.

Heidelberg was a seat of government of the former Electorate of the Palatinate and is a popular tourist destination due to its romantic cityscape, including Heidelberg Castle, the Philosophers' Walk, and the Baroque old town.
### Response: Heidelberg has the oldest University in Germany. The city is a scientific hub and home to several internationally renowned research facilities. It was designated a "City of Literature" by the UNESCO Creative Cities Network.