### Instruction: What is the significance of Thanks Giving.
### Response: The first American Thanksgiving was celebrated 43 years later in 1621 at the site of Plymouth Plantation, in Massachusetts. The Wampanoag Native Americans helped the pilgrims who arrived in Massachusetts cultivate the land and fish, saving them from starvation. At harvest time in the winter of 1621, they were very thankful that they had a good crop of food to eat during the coming winter. They thanked God and the Wampanoags for teaching them how to grow crops. The Thanksgiving holiday became a national phenomenon during the Civil War and a true national holiday during FDR's presidency.