TaoMedAI/RareMedData huggingface dataset:
Gene: PRNP
Phenotype: Autosomal dominant inheritance (HP:0000006)
Associated disease: SPONGIFORM ENCEPHALOPATHY WITH NEUROPSYCHIATRIC FEATURES (OMIM:606688)
Gene: PRNP
Phenotype: Autosomal dominant inheritance (HP:0000006)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Myoclonus (HP:0001336)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Myoclonus (HP:0001336)
Associated disease: FATAL FAMILIAL INSOMNIA (OMIM:600072)
Gene: PRNP
Phenotype: Myoclonus (HP:0001336)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Myoclonus (HP:0001336)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Myoclonus (HP:0001336)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Dysmetria (HP:0001310)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Dysmetria (HP:0001310)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Abnormal cerebellum morphology (HP:0001317)
Associated disease: Gerstmann-Straussler-Scheinker syndrome; Subacute spongiform encephalopathy, Gerstmann-Straussler type (ORPHA:356)
Gene: PRNP
Phenotype: Abnormal cerebellum morphology (HP:0001317)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Reduced tendon reflexes (HP:0001315)
Associated disease: Gerstmann-Straussler-Scheinker syndrome; Subacute spongiform encephalopathy, Gerstmann-Straussler type (ORPHA:356)
Gene: PRNP
Phenotype: Parkinsonism (HP:0001300)
Associated disease: SPONGIFORM ENCEPHALOPATHY WITH NEUROPSYCHIATRIC FEATURES (OMIM:606688)
Gene: PRNP
Phenotype: Parkinsonism (HP:0001300)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Abnormal pupillary function (HP:0007686)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Constipation (HP:0002019)
Associated disease: FATAL FAMILIAL INSOMNIA (OMIM:600072)
Gene: PRNP
Phenotype: Constipation (HP:0002019)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Dysphagia (HP:0002015)
Associated disease: FATAL FAMILIAL INSOMNIA (OMIM:600072)
Gene: PRNP
Phenotype: Dysphagia (HP:0002015)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Cognitive impairment (HP:0100543)
Associated disease: Gerstmann-Straussler-Scheinker syndrome; Subacute spongiform encephalopathy, Gerstmann-Straussler type (ORPHA:356)
Gene: PRNP
Phenotype: Cognitive impairment (HP:0100543)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Cognitive impairment (HP:0100543)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Cognitive impairment (HP:0100543)
Associated disease: Familial Alzheimer-like prion disease (ORPHA:280397)
Gene: PRNP
Phenotype: Bradykinesia (HP:0002067)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Bradykinesia (HP:0002067)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Bradykinesia (HP:0002067)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Gait ataxia (HP:0002066)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Gait ataxia (HP:0002066)
Associated disease: Gerstmann-Straussler-Scheinker syndrome; Subacute spongiform encephalopathy, Gerstmann-Straussler type (ORPHA:356)
Gene: PRNP
Phenotype: Gait ataxia (HP:0002066)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Gait ataxia (HP:0002066)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Gait ataxia (HP:0002066)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Rigidity (HP:0002063)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Rigidity (HP:0002063)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Abnormal pyramidal tract morphology (HP:0002062)
Associated disease: Gerstmann-Straussler-Scheinker syndrome; Subacute spongiform encephalopathy, Gerstmann-Straussler type (ORPHA:356)
Gene: PRNP
Phenotype: Truncal ataxia (HP:0002078)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Chorea (HP:0002072)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Chorea (HP:0002072)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Chorea (HP:0002072)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Progressive cerebellar ataxia (HP:0002073)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Limb ataxia (HP:0002070)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Abnormality of extrapyramidal motor function (HP:0002071)
Associated disease: Gerstmann-Straussler-Scheinker syndrome; Subacute spongiform encephalopathy, Gerstmann-Straussler type (ORPHA:356)
Gene: PRNP
Phenotype: Abnormality of extrapyramidal motor function (HP:0002071)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Abnormal central sensory function (HP:0011730)
Associated disease: Gerstmann-Straussler-Scheinker syndrome; Subacute spongiform encephalopathy, Gerstmann-Straussler type (ORPHA:356)
Gene: PRNP
Phenotype: Jaw pain (HP:0040264)
Associated disease: Familial Alzheimer-like prion disease (ORPHA:280397)
Gene: PRNP
Phenotype: Babinski sign (HP:0003487)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Cerebral cortical atrophy (HP:0002120)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Ventriculomegaly (HP:0002119)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Abnormal basal ganglia morphology (HP:0002134)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Apnea (HP:0002104)
Associated disease: FATAL FAMILIAL INSOMNIA (OMIM:600072)
Gene: PRNP
Phenotype: Apraxia (HP:0002186)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Neurofibrillary tangles (HP:0002185)
Associated disease: SPONGIFORM ENCEPHALOPATHY WITH NEUROPSYCHIATRIC FEATURES (OMIM:606688)
Gene: PRNP
Phenotype: Neurofibrillary tangles (HP:0002185)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Gliosis (HP:0002171)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Gliosis (HP:0002171)
Associated disease: SPONGIFORM ENCEPHALOPATHY WITH NEUROPSYCHIATRIC FEATURES (OMIM:606688)
Gene: PRNP
Phenotype: Vestibular nystagmus (HP:0010542)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Sleep apnea (HP:0010535)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Paresthesia (HP:0003401)
Associated disease: Gerstmann-Straussler-Scheinker syndrome; Subacute spongiform encephalopathy, Gerstmann-Straussler type (ORPHA:356)
Gene: PRNP
Phenotype: Middle age onset (HP:0003596)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Middle age onset (HP:0003596)
Associated disease: SPONGIFORM ENCEPHALOPATHY WITH NEUROPSYCHIATRIC FEATURES (OMIM:606688)
Gene: PRNP
Phenotype: Adult onset (HP:0003581)
Associated disease: FATAL FAMILIAL INSOMNIA (OMIM:600072)
Gene: PRNP
Phenotype: Adult onset (HP:0003581)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Insomnia (HP:0100785)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Insomnia (HP:0100785)
Associated disease: FATAL FAMILIAL INSOMNIA (OMIM:600072)
Gene: PRNP
Phenotype: Insomnia (HP:0100785)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Hypersomnia (HP:0100786)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Global brain atrophy (HP:0002283)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Global brain atrophy (HP:0002283)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Mania (HP:0100754)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Poor fine motor coordination (HP:0007010)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Progressive forgetfulness (HP:0007017)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Attention deficit hyperactivity disorder (HP:0007018)
Associated disease: Familial Alzheimer-like prion disease (ORPHA:280397)
Gene: PRNP
Phenotype: Central nervous system degeneration (HP:0007009)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Extrapyramidal muscular rigidity (HP:0007076)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Aphasia (HP:0002381)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Sleep abnormality (HP:0002360)
Associated disease: Gerstmann-Straussler-Scheinker syndrome; Subacute spongiform encephalopathy, Gerstmann-Straussler type (ORPHA:356)
Gene: PRNP
Phenotype: Sleep abnormality (HP:0002360)
Associated disease: Familial Alzheimer-like prion disease (ORPHA:280397)
Gene: PRNP
Phenotype: Frequent falls (HP:0002359)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Hypokinesia (HP:0002375)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Loss of speech (HP:0002371)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: EEG abnormality (HP:0002353)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Memory impairment (HP:0002354)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Memory impairment (HP:0002354)
Associated disease: SPONGIFORM ENCEPHALOPATHY WITH NEUROPSYCHIATRIC FEATURES (OMIM:606688)
Gene: PRNP
Phenotype: Memory impairment (HP:0002354)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Memory impairment (HP:0002354)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Rapidly progressive (HP:0003678)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Rapidly progressive (HP:0003678)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Unsteady gait (HP:0002317)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: EEG with persistent abnormal rhythmic activity (HP:0010846)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Trigeminal neuralgia (HP:0100661)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Progressive extrapyramidal muscular rigidity (HP:0007158)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Incoordination (HP:0002311)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Incoordination (HP:0002311)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Clumsiness (HP:0002312)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Clumsiness (HP:0002312)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Focal T2 hyperintense basal ganglia lesion (HP:0007183)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Abnormally slow thought process (HP:0031843)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Hyperactive deep tendon reflexes (HP:0006801)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Short REM sleep (HP:5200360)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Nystagmus (HP:0000639)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Nystagmus (HP:0000639)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Diplopia (HP:0000651)
Associated disease: FATAL FAMILIAL INSOMNIA (OMIM:600072)
Gene: PRNP
Phenotype: Diplopia (HP:0000651)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Abnormality of ocular smooth pursuit (HP:0000617)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Fever (HP:0001945)
Associated disease: FATAL FAMILIAL INSOMNIA (OMIM:600072)
Gene: PRNP
Phenotype: Fever (HP:0001945)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Supranuclear gaze palsy (HP:0000605)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Supranuclear gaze palsy (HP:0000605)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Abnormal pineal melatonin secretion (HP:0012689)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Akinetic mutism (HP:0012672)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Thalamic hypometabolism in FDG PET (HP:0012660)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Sleep-wake cycle disturbance (HP:0006979)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Jerky head movements (HP:0006961)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Involuntary movements (HP:0004305)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Diffuse spongiform leukoencephalopathy (HP:0006943)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Abnormal shoulder morphology (HP:0003043)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Basal ganglia gliosis (HP:0006999)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Personality changes (HP:0000751)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Personality changes (HP:0000751)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Personality changes (HP:0000751)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Personality changes (HP:0000751)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Personality changes (HP:0000751)
Associated disease: SPONGIFORM ENCEPHALOPATHY WITH NEUROPSYCHIATRIC FEATURES (OMIM:606688)
Gene: PRNP
Phenotype: Hallucinations (HP:0000738)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Hallucinations (HP:0000738)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Hallucinations (HP:0000738)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Irritability (HP:0000737)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Irritability (HP:0000737)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Anxiety (HP:0000739)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Anxiety (HP:0000739)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Anxiety (HP:0000739)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Anxiety (HP:0000739)
Associated disease: Familial Alzheimer-like prion disease (ORPHA:280397)
Gene: PRNP
Phenotype: Anxiety (HP:0000739)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Short attention span (HP:0000736)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Delayed speech and language development (HP:0000750)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Delusion (HP:0000746)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Delusion (HP:0000746)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Delusion (HP:0000746)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Delusion (HP:0000746)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Apathy (HP:0000741)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Apathy (HP:0000741)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Depression (HP:0000716)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Depression (HP:0000716)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Depression (HP:0000716)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Depression (HP:0000716)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Depression (HP:0000716)
Associated disease: Familial Alzheimer-like prion disease (ORPHA:280397)
Gene: PRNP
Phenotype: Depression (HP:0000716)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Depression (HP:0000716)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Aggressive behavior (HP:0000718)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Aggressive behavior (HP:0000718)
Associated disease: SPONGIFORM ENCEPHALOPATHY WITH NEUROPSYCHIATRIC FEATURES (OMIM:606688)
Gene: PRNP
Phenotype: Aggressive behavior (HP:0000718)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Emotional lability (HP:0000712)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Emotional lability (HP:0000712)
Associated disease: Familial Alzheimer-like prion disease (ORPHA:280397)
Gene: PRNP
Phenotype: Emotional lability (HP:0000712)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Emotional lability (HP:0000712)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Restlessness (HP:0000711)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Restlessness (HP:0000711)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Hyperorality (HP:0000710)
Associated disease: SPONGIFORM ENCEPHALOPATHY WITH NEUROPSYCHIATRIC FEATURES (OMIM:606688)
Gene: PRNP
Phenotype: Dementia (HP:0000726)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Dementia (HP:0000726)
Associated disease: FATAL FAMILIAL INSOMNIA (OMIM:600072)
Gene: PRNP
Phenotype: Dementia (HP:0000726)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Dementia (HP:0000726)
Associated disease: Gerstmann-Straussler-Scheinker syndrome; Subacute spongiform encephalopathy, Gerstmann-Straussler type (ORPHA:356)
Gene: PRNP
Phenotype: Dementia (HP:0000726)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Dementia (HP:0000726)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Dementia (HP:0000726)
Associated disease: CREUTZFELDT-JAKOB DISEASE (OMIM:123400)
Gene: PRNP
Phenotype: Dementia (HP:0000726)
Associated disease: SPONGIFORM ENCEPHALOPATHY WITH NEUROPSYCHIATRIC FEATURES (OMIM:606688)
Gene: PRNP
Phenotype: Dementia (HP:0000726)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Psychosis (HP:0000709)
Associated disease: GERSTMANN-STRAUSSLER DISEASE (OMIM:137440)
Gene: PRNP
Phenotype: Atypical behavior (HP:0000708)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Atypical behavior (HP:0000708)
Associated disease: Familial Alzheimer-like prion disease (ORPHA:280397)
Gene: PRNP
Phenotype: Abdominal symptom (HP:0011458)
Associated disease: Familial Alzheimer-like prion disease (ORPHA:280397)
Gene: PRNP
Phenotype: Young adult onset (HP:0011462)
Associated disease: HUNTINGTON DISEASE-LIKE 1 (OMIM:603218)
Gene: PRNP
Phenotype: Abnormality of mental function (HP:0011446)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Increased circulating cortisol level (HP:0003118)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Hypertension (HP:0000822)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Simultanapraxia (HP:0040201)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Reduced attention regulation (HP:5200044)
Associated disease: FFI; Fatal familial insomnia (ORPHA:466)
Gene: PRNP
Phenotype: Limb myoclonus (HP:0045084)
Associated disease: Gerstmann-Straussler-Scheinker syndrome; Subacute spongiform encephalopathy, Gerstmann-Straussler type (ORPHA:356)
Gene: PRNP
Phenotype: Senile plaques (HP:0100256)
Associated disease: Inherited CJD; Inherited Creutzfeldt-Jakob disease (ORPHA:282166)
Gene: PRNP
Phenotype: Jerky ocular pursuit movements (HP:0008003)
Associated disease: HDL1; Early-onset prion disease with prominent psychiatric features; Huntington disease-like 1 (ORPHA:157941)
Gene: PRNP
Phenotype: Hyperhidrosis (HP:0000975)
Associated disease: FATAL FAMILIAL INSOMNIA (OMIM:600072)