Disease (ORPHA:90291):
Systemic sclerosis
Systemic scleroderma

Associated phenotypes (HPO):
id: HP:0001072
hpo_term: Thickened skin
chpo_term: 皮肤增厚
id: HP:0002829
hpo_term: Arthralgia
chpo_term: 关节疼痛
id: HP:0003326
hpo_term: Myalgia
chpo_term: 肌痛
id: HP:0003493
hpo_term: Antinuclear antibody positivity
chpo_term: 抗核抗体阳性
id: HP:0011024
hpo_term: Abnormality of the gastrointestinal tract
chpo_term: 胃肠道异常
id: HP:0030880
hpo_term: Raynaud phenomenon
chpo_term: 雷诺现象
id: HP:0031359
hpo_term: Cutaneous sclerotic plaque
chpo_term: 皮肤硬化斑
id: HP:0000077
hpo_term: Abnormality of the kidney
chpo_term: 肾脏异常
id: HP:0000160
hpo_term: Narrow mouth
chpo_term: 小口畸形
id: HP:0001009
hpo_term: Telangiectasia
chpo_term: 毛细血管扩张
id: HP:0001232
hpo_term: Nail bed telangiectasia
chpo_term: 甲床毛细血管扩张
id: HP:0001324
hpo_term: Muscle weakness
chpo_term: 肌无力
id: HP:0001386
hpo_term: Joint swelling
chpo_term: 关节肿胀
id: HP:0002031
hpo_term: Abnormal esophagus morphology
chpo_term: 食管形态结构异常
id: HP:0002206
hpo_term: Pulmonary fibrosis
chpo_term: 肺纤维化
id: HP:0003236
hpo_term: Elevated circulating creatine kinase concentration
chpo_term: 血清肌酸磷酸激酶升高
id: HP:0005590
hpo_term: Spotty hypopigmentation
chpo_term: 点滴状色素减退
id: HP:0006121
hpo_term: Acral ulceration
chpo_term: 肢端溃疡
id: HP:0006261
hpo_term: Abnormal phalangeal joint morphology of the hand
chpo_term: 指（趾）骨关节形态异常
id: HP:0006530
hpo_term: Abnormal pulmonary interstitial morphology
chpo_term: 肺间质形态异常
id: HP:0007400
hpo_term: Irregular hyperpigmentation
chpo_term: 不规则色素沉着
id: HP:0011838
hpo_term: Sclerodactyly
chpo_term: 指硬皮病
id: HP:0012531
hpo_term: Pain
chpo_term: 疼痛
id: HP:0025131
hpo_term: Finger swelling
chpo_term: 手指肿胀
id: HP:0025520
hpo_term: Calcinosis cutis
chpo_term: 皮肤钙质沉着症
id: HP:0030859
hpo_term: Anti-topoisomerase I antibody positivity
chpo_term: 抗拓扑异构酶 I 抗体阳性
id: HP:0030873
hpo_term: Anti-centromere antibody positivity
chpo_term: 抗着丝粒抗体阳性
id: HP:0031293
hpo_term: Digital pitting scar
chpo_term: 手指凹陷性疤痕
id: HP:0031917
hpo_term: Digital ulcer
chpo_term: 指趾溃疡
id: HP:0033038
hpo_term: Anti-RNA-polymerase-III-autoantibody positivity
chpo_term: 抗RNA聚合酶Ⅲ自身抗体阳性
id: HP:0033394
hpo_term: Anti-carbonic anhydrase II antibody positivity
chpo_term: 抗碳酸酐酶II抗体阳性
id: HP:0033560
hpo_term: Anti-PM-Scl antibody positivity
chpo_term: 抗PM-Scl抗体阳性
id: HP:0034078
hpo_term: Anti-centromere protein A antibody positivity
chpo_term: 抗着丝力蛋白A抗体阳性
id: HP:0034079
hpo_term: Anti-centromere protein B antibody positivity
chpo_term: 抗着丝力蛋白B抗体阳性
id: HP:0034080
hpo_term: Anti-U3 RNP antibody positivity
chpo_term: 抗U3 RNP抗体阳性
id: HP:0034081
hpo_term: Anti-Th/To antibody positivity
chpo_term: 抗Th/To抗体阳性
id: HP:0034082
hpo_term: Anti-bicaudal D2 antibody positivity
chpo_term: 抗双尾D2抗体阳性
id: HP:0034083
hpo_term: Anti-nucleolus-organizing region antibody positivity
chpo_term: 抗核仁组织区抗体阳性
id: HP:0034085
hpo_term: Anti-PM-Scl100 antibody positivity
chpo_term: 抗PM-Scl100抗体阳性
id: HP:0034086
hpo_term: Anti-PM-Scl75 antibody positivity
chpo_term: 抗PM-Scl75抗体阳性
id: HP:0034087
hpo_term: Anti-U11/U12 RNP antibody positivity
chpo_term: 抗U11/U12 RNP抗体阳性
id: HP:0034088
hpo_term: Anti-Ku antibody positivity
chpo_term: 抗Ku抗体阳性
id: HP:0034089
hpo_term: Anti-B23 antibody positivity
chpo_term: 抗B23抗体阳性
id: HP:0034090
hpo_term: Anti-RuvBL1/2 antibody positivity
chpo_term: 抗RuvBL1/2抗体阳性
id: HP:0034091
hpo_term: Anti-platelet derived growth factor receptor
chpo_term: 抗血小板衍生生长因子受体
id: HP:0034093
hpo_term: Anti-Ro52/TRIM21 antibody positivity
chpo_term: 抗Ro52/TRIM21抗体阳性
id: HP:0034094
hpo_term: Anti-angiotensin receptor type-1 antibody positivity
chpo_term: 抗血管紧张素1型受体抗体阳性
id: HP:0034095
hpo_term: Anti-endothelin-1 type A receptor antibody positivity
chpo_term: 抗A型内皮素受体抗体阳性
id: HP:0034117
hpo_term: Anti-angiotensin-converting enzyme 2 antibody positivity
chpo_term: 抗血管紧张素转换酶2抗体阳性
id: HP:4000170
id: HP:4000171
id: HP:0000083
hpo_term: Renal insufficiency
chpo_term: 肾功能不全
id: HP:0000093
hpo_term: Proteinuria
chpo_term: 蛋白尿
id: HP:0000099
hpo_term: Glomerulonephritis
chpo_term: 肾小球肾炎
id: HP:0000966
hpo_term: Hypohidrosis
chpo_term: 少汗症
id: HP:0000989
hpo_term: Pruritus
chpo_term: 瘙痒
id: HP:0001279
hpo_term: Syncope
chpo_term: 晕厥
id: HP:0001369
hpo_term: Arthritis
chpo_term: 关节炎
id: HP:0001371
hpo_term: Flexion contracture
chpo_term: 屈曲挛缩
id: HP:0001581
hpo_term: Recurrent skin infections
chpo_term: 复发性皮肤感染
id: HP:0001596
hpo_term: Alopecia
chpo_term: 脱发
id: HP:0001701
hpo_term: Pericarditis
chpo_term: 心包炎
id: HP:0001708
hpo_term: Right ventricular failure
chpo_term: 右心衰竭
id: HP:0001919
hpo_term: Acute kidney injury
chpo_term: 急性肾损伤
id: HP:0002015
hpo_term: Dysphagia
chpo_term: 吞咽困难
id: HP:0002020
hpo_term: Gastroesophageal reflux
chpo_term: 胃食管反流
id: HP:0002092
hpo_term: Pulmonary arterial hypertension
chpo_term: 肺动脉高压
id: HP:0002094
hpo_term: Dyspnea
chpo_term: 呼吸困难
id: HP:0002244
hpo_term: Abnormality of the small intestine
chpo_term: 小肠异常
id: HP:0002250
hpo_term: Abnormal large intestine morphology
chpo_term: 大肠形态异常
id: HP:0002577
hpo_term: Abnormal stomach morphology
chpo_term: 胃形态异常
id: HP:0002578
hpo_term: Gastroparesis
chpo_term: 胃轻瘫
id: HP:0002584
hpo_term: Intestinal bleeding
chpo_term: 肠道出血
id: HP:0002604
hpo_term: Gastrointestinal telangiectasia
chpo_term: 胃肠道毛细血管扩张
id: HP:0002607
hpo_term: Bowel incontinence
chpo_term: 大便失禁
id: HP:0002617
hpo_term: Vascular dilatation
chpo_term: 血管扩张
id: HP:0002754
hpo_term: Osteomyelitis
chpo_term: 骨髓炎
id: HP:0009771
hpo_term: Osteolytic defects of the phalanges of the hand
chpo_term: 指骨溶骨缺陷
id: HP:0011799
hpo_term: Abnormality of facial soft tissue
chpo_term: 面部软组织异常
id: HP:0012185
hpo_term: Constrictive median neuropathy
chpo_term: 压迫性正中神经病变
id: HP:0012592
hpo_term: Albuminuria
chpo_term: 蛋白尿
id: HP:0012622
hpo_term: Chronic kidney disease
chpo_term: 慢性肾病
id: HP:0012819
hpo_term: Myocarditis
chpo_term: 心肌炎
id: HP:0031329
hpo_term: Interstitial cardiac fibrosis
chpo_term: 间质性心脏纤维化
id: HP:0100580
hpo_term: Barrett esophagus
chpo_term: Barrett食管
id: HP:0100758
hpo_term: Gangrene
chpo_term: 坏疽