Genre: Information/Explanation

Molecular and Cellular mechanisms underpinning Vascular Calcification and Angiogenesis Vascular calcification is a common complication of many diseases including atherosclerosis , diabetes , renal disease , hypertension , vein graft failure and calciphylaxis . Recent studies have shown that there is a strong association between the presence of vascular calcification and adverse clinical events such as myocardial infarction and stroke . However , little is known about how the deposition of mineral in vessels is controlled . We have shown that vascular pericytes have multi-lineage potential and can differentiate into osteoblasts and chondrocytes in vitro and in vivo . We have also shown that these cells can deposit a calcified matrix resembling that found in calcified atherosclerotic plaques , suggesting that pericytes may mediate , at least in part , vascular calcification . We have recently demonstrated that several genes that are implicated in the pathological calcification of arteries , namely matrix Gla protein , Axl receptor tyrosine kinase and HtrA1 serine protease are all differentially expressed during pericyte differentiation . We are currently using molecular , cellular and biochemical approaches to elucidate the mechanisms by which each of these proteins regulates calcification . In time , this integrated programme of research will provide important insights into the pathogenesis of vascular calcification and may identify potential targets for the therapeutic manipulation of this event . Angiogenesis is the formation of new blood vessels from an existing vascular bed . It is of fundamental importance in many physiological and pathological conditions , including embryonic development , wound healing , atherosclerosis , diabetic retinopathy , psoriasis and tumour growth and metastasis . Angiogenesis is a complex process involving changes in endothelial cell phenotype , extracellular matrix remodelling and stabilisation of the newly formed blood vessels . We are currently employing a multidisciplinary approach to define the roles of specific angiogenic factors and matrix proteins in regulating endothelial cell-pericyte interactions that are crucial for vessel stabilisation . We aim to translate this work into the development of novel anti-angiogenic and pro-angiogenic strategies for the treatment of diseases characterised by abnormal vascularisation . Combining the strengths of UMIST and The Victoria University of Manchester The University of Manchester :: Disclaimer | Privacy | Copyright notice | Accessibility | Feedback | Contact us