凌锋.脑血管病理论与实践[M].北京:人民卫生出版社, 2007:220 李虹伟,彭晖.他汀类药物非调脂作用的研究进展[J].临床药物治疗杂志,2008。6(2):49-51 [3]Hofnagel 0,Luechtenborg B,Eschert H,et a1.Pravestatin Inhibits Expression likeOxidized Low-Density Lipoprotein Recep- tor(LOX—1)in Watsnabe Heritable Hyperlipidemie hBabbits:A New Pleiotmpie Effect ofStatins[J].ArteriesclerThromb Vase Bi. ol,2006,26:604-610 [4]John s,Schneider MP,Delles C,et aI.“Pjd independent effect sof statins endothelialfunction bioavailability nitricoxide hypercholesterolemicpatients[J].Am Heart J,2005,149:473 [5]孔德莲,申 霞.他汀类药物的非降脂作用[J].中国临床康 复,2006,40(10):117-119 [6]Ortegu M,Busies C,Hemandes-Presa MA,et a1.Atorvas-tatin pduees NF—kappaB activation ehemokineexpression vascular smooth muscle cells mononuclearcells[J].Athero—sclero- sis,2005,47:253 [7]Tunon J,Martin Ventura JL,Blanco-Colio LM,et a1.Mechanisms statinsinstroke[J].Expert Opin.TherTargets,2007, 11:273-278 董红梅,黄岚,宋耀明,等.急性冠脉综合征患者血浆氧化型低密度脂蛋白、高敏c反应蛋白与血管内皮损伤的关系[J]. 中国动脉硬化杂志.2006,14(3):227-229 [9]Nisscn SE。Niehdls SJ,Sipahi L,et a1.Effect veryhigh.intensi- ty statin therapy onregression coronaryatherosclerosis:The As- TEBOID trial[J].JAMA,2006,295(13):1 556.1 565 [10]Amarenco P,Labreuche J,Lavallee P,et a1.Statins strokepre- vention carotidatheresclerosis:systematic review up.to—date meta.analysis[J].Stroke,2004。35:2 902-2 909 [11] 徐婕.龚建祖.辛伐他汀对高血压合并动脉粥样硬化患者 内皮功能的影响[J].心脑血管病防治,2009,(9)1:17.19 [12]Colhoun HM,Betteridge DJ,Durrington PN,et aI.Primary pre一 [13] [14] [15] [16] [17】 [18] [19] [20] [21] [22] venfion cardiovasculardiseae type2diabe. tes CollaborativeAtorvastatin Diabete Study(CARDS): muhicentre randomized place-controlled[J].Lancet,2004。364: 685枷 李桂平,彭娜,李绪娴,等.阿托伐他汀对2型糖尿病患者 血管内皮功能及颈动脉粥样硬化的影响[J].实用医学杂 志,2009,4:631-633 Saeco RL,Adams R,Alber8 G,et a1.Guidelines ischemiestroke transientischemie tack:astatement healtheareprofessionals from AmericanHeart Association American Stroke Asseciation Council Cardiovaacular Radiol— ogy Intervention:theAmerican Academyof Neurology affirms valueofthis guideline[J].Circulation,2006,113:409-449 Amareneo P,BogonsslaVsky J,Callahan A,et a1.HigII-dose atorvaztafin after stroke transientischemic attack(SPARCL) Zn#JMed,2006,355:549-559 Ovbiagele B,Saver JL.Itensive statin therapy after stroke tran—sient ischemie attack:a SPARCL 8[J].Stroke,2007。38: l110.1 112 Antithrombotie Trialists’Collaboration.Collaborative meta—armly— sis randomizedtrials antiplatelettherapy prevention0f death,myocardial infarction。and stroke hi咖riskpatients[J]. BMJ,2002。324:71-86 Rnshid P。Lenoardi Bee J。Bath P.Blood pressure reductionId secondaD"prevention othervascular events:n sys- temetic review[J].Stroke,2003,34:2 741-2 748 Adams RJ,Albers G,Alberts MJ。et a1.Update AHA/ASA Recommendations PatientsWith Stroke TransientIschemic Attack[J].Stroke,2008。39: l647,l 652 Davidsonn MH.Toth PP.Combination therapy manage-ment complexdyslipidemias[J]。Gurr opin Lipidol,2004。15 (4):423-431 de Lemes JA。Blazing MA,Wiviott SD,et a1.A ZInvesti帮ttor8.Early intensive vs adelayed conflervative simvastatin strat- egy acutecoronary syndromes:phase Zof Atoztrial[J].JAMA,2004,292:1 307-1 316 张伟杰,唐伟方.他汀类药物的药动学及与其他药物的相互 作用[J].药学进展,2009,33(3):119.123 [收稿日期:2009—08—31] 万方数据 他汀类药物与缺血性脑血管病 作者: 张云霞, 作者单位:张云霞(石河子大学医学院), 郑勇(石河子大学医学院第一附属医院消化内科), (石河子大学医学院病理学教研室,新疆石河子,832002)