文章摘要
1复旦大学基础医学院病理学系,上海 200032
通讯:刘学光Email:glxg69@shmu.edu.cn
DOI:10.3978/j.issn.2095-6959.2018.06.030
基金:国家自然科学基金 (81100505)
摘要
肾小球壁层上皮细胞(parietal epithelial cells,PECs)是内衬于鲍曼囊(肾小球囊)的一层扁平上皮,与足细胞来源于同一细胞谱系,在成熟肾中两者解剖关系邻近,是备受关注的具备向足细胞分化潜能的“前体细胞”。近年研究发现在正常肾及以足细胞损伤为特征的肾病动物模型和人肾小球疾病中,PECs可向足细胞表型发生转化,且Wilms肿瘤抑制基因(Wilms’ tumor 1,WT-1),Notch, Wnt/β-catenin,miR-193a及生长阻滞特异性蛋白1(growth arrest-specific protein 1,Gas1)等信号通路发挥重要调控作用。
关键词:肾小球;壁层上皮细胞;足细胞;前体细胞
Research progress in differentiation of parietal epithelial cells as progenitor cells into podocytes
Authors:1XUE Ruqun,1LIU Xueguang
1Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
CorrespondingAuthor:LIU XueguangEmail:glxg69@shmu.edu.cn
DOI:10.3978/j.issn.2095-6959.2018.06.030
Foundation:This work was supported by the National Natural Science Foundation of China (81100505)
Abstract
Glomerular parietal epithelial cells (PECs) is squamous epithelium wh