Challenges in the development of an HIV-1 vaccine1)extensive viral class and sequence diversity2)early establishment of latent viral reservoirs3)immune correlates of protection unclear4)viral evasion of humoral and cellular immune responses.5)antibody responses typically type-specific6)no method exists to elicit broadly reactive neutralizing antibodies7)attenuated viruses unsafe for human use8)lack of small-animal model9)little pharmaceutical interest翻译:在HIV-1疫苗的发展挑战