【关键词】依诺肝素;瑞替普酶;急性心肌梗死;冠状动脉再通【中图分类号】R972【文献标识码]A【文章编号】1674-4721( 2014) 01( b) -0075-03Cl i ni calstudyon the di fferentusageofenoxapari ni npati ents w i th acutem yocardi al i nfarcti onrecei vi ng retepl ase therapyCH ENXue—bi nM ALi - pi ngW A N GFeng- l anW AN G 五nLIUYu-fi eD epartm entofCardi ol ogy,Peopl e’ S H ospi talofPuyang Ci ty,H enan Provi nce,Puyang457000,Chi na【Abstract】O bj ecti veTo eval uate theeffi cayandsafetyof di fferentusageofenoxapari ni npati entsw i th acut em yocar—di al i nfarcti on(AM I)recei vi ng retepl ase throm bol ysi s therapy.M ethods N i nty pati entsw ererandom l ydi vi ded i nto threegroups byorder of adm i ssi on and each groupw ere 30 cases.Thepati entsofgroupA w ere treated w i th 30m genoxa-pari n byi ntravenousi nj ecti onbeforethrom bol ysi s,andrecei ved1m g/kg enoxapafi n i m m edi atel y bysubcutaneousi n—j ecti onafterthrom bol ysi s.30 pati entsofgroupB recei ved1m g/kg enoxapari n bysubcutaneousi nj ecti onbefore throm —bol ysi s.The pati entsofgroupC w erei nj ectedsubcutaneous w i th1m g/kg enoxapari n i m m edi atel yafter throm bol ysi s.Then,al l pati entsof threegroupsw erei nj ected subcutaneousl yw i th 1m g/kg enoxapari ntw i ce adayandrepeatedfor 5—8days.Therate of recanal i zati on and the events ofhem orrhageofpost—throm bol ysi sw as observed after 60 m i n and 90m i nrespecti vel y.Resul tsThe rate of recanal i zati on of 60 m i n afterthrom bol ysi si ngroupA.B and C w as 83.3%.63.3%and60.0%respecti vel y.therate of recanal i zati on i ngroupA w assi gni fi cantl y hi gherthan that ofgroupB andgroupCrespecti vel y(P0.05).Therate of recanal —i zati on of 90 m i n afterthrom bol ysi si ngroup A,B and C w as 90.0%,86.7%and83.3%respecti vel y,therew as nosi gni fi —cant di fferenceam ongthreegroupsfP>0.05).N oseverehem orrhagesoccurred i n al l threegroupsand the i nci dence ofhem orrhagi cevents i ngroupA,B, and C w as 13.3%,10.o%and 10.0%respecti vel y,therew as nosi gni fi cantdi fferenceam ongthreegroups( P>0.05) .Concl usi onBeforethrom bol yti ctherapyw i thretepl ase,i tcan shoden the ti m e ofcoronaryre—canal i zati onand shoul d not i ncrease severehem orrhage com pl i cati ons by i ntravenous i nj ecti on of 30m g enoxapari n.【Key w ords】Enoxapari n;Retepl ase;Acute m yocardi al i nfarcti on;Coronaryrecanal i zati on