1.孟玉霞 韩向午 李春海 等.乳腺癌患者的 碱性谷胱甘肽S-转移酶[J]. 中国肿瘤临床 1998 25(2): 119*121.[9]Significance of Serum and tissue Glutathione S-transferase Activityin Patients with Breast CancerCHEN Yu1 Ll Ming-ren2 SHENG Jian1 et al(1. Department of Biochemistry and Molecular Biology Fujian Medical University Fuzhou350004 China2. Department of Tumours Surgery The Affiliated First Hospitor Fujian Medical University Fuzhou350005 China)ABSTRACT:ObjectiveTo study the relationship between activity of glutathione s-transferase(GST) and the occurence development of breast cancer.MethodsThe activity of GST in serum carci-noma tissue and nearby noncancerous tissue and tissue showing atypical hyperplasia or simple hyperpla-sia was assayed in 60 cases of breast carcinoma(30 cases of node-positive breast cancer) and 30 cases ofatypical hyperplasia of breast 30 cases of simple hyperplasia of breast.Results(1)The activity of GSTin serum and tissue of breast carcinomas was higher than those of atypical hyperplasia group(P<0. 01)and simple hyperplasia group(P<0. 01).(2)The activity of GST in tissue of breast carcinoma was high-er than that of nearby noncarcerous tissue(P<0. 05).The activity in nearby noncarcerous tissue washigher than that in normal tissue(P<0. 05).(3) The activity of GST was correlated with histologicalgrading(P<0. 05) and lymph node involvement(P<0. 05).(4)The activity of GST in serum of patientafter operation was lower than before operation(P<0. 01).ConclusionThe GST activity and the inci-dence development of breast cancer are closely related.It is useful as a reference for breast cancer diag-nosis and monitoring the precarcinous lesions.KEY WORDS:breast cancer; glutathione s-transferase; tumor marker653Journal of Fujian Medical UniversityVol. 35No. 4Dec 2001