实用妇产科杂志 2013 年 8 月第 29 卷第 8 期 Journal of Practical Obstetrics and Gynecology 2013 Aug. Vol. 29,No.8基金项目:温州市科技局资助项目(编号:Y20070099)文章编号:1003-6946(2013)08-603-04可溶性酪氨酸激酶受体 1/胎盘生长因子比值在子痫前期诊断中的价值朱丽丹 1 ,江明华 1 ,张小芬 1 ,李仁良 2 ,夏淑琦 2(1. 温州医学院附属第二医院,浙江 温州 325000;2. 浙江省温州市第三人民医院,浙江 温州 325000)【摘要】 目的:探讨血清、尿液可溶性酪氨酸激酶受体 1/胎盘生长因子(sFlt-1/PLGF)比值在子痫前期的诊断价值。方法:检测及比较分析 40 例正常孕妇、38 例轻度子痫前期与 32 例重度子痫前期孕妇血清及尿液中 PLGF、sFlt-1 及 sFlt-1/PLGF 比值的变化,将尿液 PLGF、sFlt-1 分别与血清 PLGF、sFlt-1 进行 Person 相关分析,并用 ROC 曲线分析血清、尿液中 sFlt-1/PLGF 比值对子痫前期的诊断价值。结果:轻度子痫前期组血清、尿液 sFlt-1/PLGF 比值高于正常对照组,重度子痫前期组 sFlt-1/PLGF 比值高于轻度子痫前期组,各组之间的差异均有统计学意义(均 P<0. 01);尿液 PLGF、sFlt-1 分别与血清 PLGF、sFlt-1 具有正相关性(r = 0. 692,r = 0. 784,均 P<0. 05);血清、尿液 sFlt-1/PLGF 比值对轻度子痫前期的 ROC 曲线下面积(AUC)分别为 0. 921、0. 935,血清、尿液 sFlt-1/PLGF 比值对重度子痫前期的 ROC 的 AUC 分别为 0. 959、0. 972。血清中 sFlt-1/PLGF 比值的 AUC 与尿液中 sFlt-1/PLGF 比值的 AUC 相比差异均无统计学意义(均P>0. 05)。结论:血清、尿液 sFlt-1/PLGF 比值在子痫前期患者中均有明显的升高,其为子痫前期的诊断提供了一个较理想的实验室指标,在临床中可以用尿液 sFlt-1/PLGF 比值替代血液sFlt-1/PLGF 比值。【关键词】 子痫前期;胎盘生长因子;可溶性酪酸激酶受体 1中图分类号:R714. 24 + 4 文献标识码:ADiagnostic Value of Soluble Tyrosine Kinase Receptor 1/Placental Growth Factorin PreeclampsiaZHU Lidan,JIANG Minghua,Zhang Xiaofeng,et al(The Second Affiliated Hospital of Wenzhou Medical College,Wenzhou Zhejiang 325000,China)【Abstract】 Objective:To explore the diagnostic value of serum and urine sFlt -1/PLGF in preeclampsia. Methods:En-zyme linked immunosorbentassay method was used to detect the levels of PLGF、sFlt-1 in serum and urine of 40 normalpregnant women(control group),38 patients with mild preeclampsia(mild preeclampsia group)and 32 patients with se-vere preeclampsia(severe preeclampsia group). The level of sFlt-1,PLGF and ratio of sFlt-1/PLGF were compared a-mong the three groups. The correlations between levels of PLGF,sFlt-1 in serum with levels of PLGF,sFlt-1 in urinewere analyzed,The diagnosis value of the ratio of sFlt-1/PLGF in serum and urine for preeclampsia was also analyzed.Results:Ratios of sFlt -1 / PLGF in serum and urine in mild preeclampsia group were significantly higher than those incontrol group,ratios of sFlt -1 / PLGF in serum and urine in severe preeclampsia group were significantly higher thanthose in mild preeclampsia group(P<0. 01). There were positive correlations between the levels of PLGF、sFlt-1 in urinewith those in serum(r=0. 692 and 0. 784,respectively,both P<0. 05);The area under the curve(AUC)of the ROCcurve of sFlt-1/PLGF ratio in serum and urine for mild preeclampsia diagnosis was 0. 921 and 0. 935 respectively;TheAUC of the ROC curve of sFlt-1/PLGF ratio in serum and urine for severe preeclampsia diagnosis was 0. 959 and 0. 972respectively. There was no significant difference on AUC of sFlt-1/PLGF ratio between in serum and that in urine. Con-clusions:The ratios of sFlt-1/PLGF in patients with preeclampsia in serum and urine were significantly elevated,whichmaybe an ideal index for the diagnosis of preeclampsia. The ratio of sFl-1/PLGF in urine can be used to replace that inserum in the diagnosis of preeclampsia.· 3 0 6 · 实用妇产科杂志 2013 年 8 月第 29 卷第 8 期 Journal of Practical Obstetrics and Gynecology 2013 Aug. Vol.29,No. 8【Key words】 Preeclampsia;Placental growth factor;Soluble tyrosine kinase receptor 1