Tg的临床意义目前限于甲状腺癌肿瘤标志物和自身免疫性甲状腺炎的抗体诊断检测,如果Tg负反馈学说成立,Tg负反馈机制异常可能与甲状腺疾病发病机制相关;假如,Tg本身或抑制甲状腺功能基因机制发生异常,Tg负调控作用减弱引起甲状腺功能基因表达增强,可能发生甲状腺功能亢进或腺瘤样结节形成;Tg负调控作用激活增强时,甲状腺激素合成功能基因表达减弱,可能引起甲状腺功能减退,Tg负反馈学说及其发生的分子机制研究可能为甲状腺疾病研究开辟新领域。致谢:感谢日本帝京大学临床检查学科铃木幸一教授、川岛晃博士对本文的贡献!参考文献:[1]WeberJ,McinnesJ,KizilirmakaC,etal.Interdependenceofthyroglobulinprocessingandthyroidhormoneexportinthemousethyroidgland[J].EurJCellBiol,2017,96(5,SI):440-56.(下转封三页)(上接126页)[2]DiJesoB,ArvanP.Thyroglobulinfrommolecularandcellularbiologytoclinicalendocrinology[J].EndocrRev,2016,37(1):2-36.[3]OdaK,LuoY,YoshiharaA,etal.FollicularthyroglobulininducescathepsinHexpressionandactivityinthyrocytes[J].BiochemBiophysResCommun,2017,483(1):541-6.[4]MaR,LatifR,DaviesTF.Thyroidfollicleformationandthyroglobulinexpressioninmultipotentendodermalstemcells[J].Thyroid,2013,23(4):385-91.[5]Wen1G.EderK,ringseisR.sterolregulatoryelement-bindingproteinsaretranscriptionalregulatorsofthethyroglobulingeneinthyroidcells[J].BiochimBiophysActa,2016,1859(8):994-1003.[6]Portulano,Paroder-BelenitskyCM,N.Carrasco.theNa+/i-symporter(NIS):mechanismandmedicalimpact[J].EndocrRev,2014,35(1):106-49.[7]ShiXZ,XueL,JinX,etal.Differentexpressionofsodium-iodideimporter(NIS)betweenlactatingbreastandthyroidtissuesMaybeduetostructuraldiffer