【关键词】阿立哌唑;舍曲林;强迫症doi:10. 3969 /j. issn. 1672 - 0369. 2013. 10. 011中图分类号:R749. 79文献标识码:A文章编号:1672 - 0369( 2013) 10 - 019 - 03A control study of Aripiprazole and Aripiprazole combined withSertraline in the treatment of obsessive - compulsive disorderYANG Qiong, ZHENG Shi - shi, GUAN Jin,et al( Guangzhou Brain Hospital,Guangzhou 510370,China)【Abstract】Objective: To explore the efficacy and safety of Aripiprazole and Aripiprazole combined with Sertraline in the treatment of obsessive- compulsive disorder. Methods:43 patients met the DSM - IV criteria for OCD were randomly divided into single drug group ( n = 21 ) and combineddrug group( n = 22) ,the single drug group was given Aripiprazole,combined drug group was given Aripiprazole combined with Sertraline,treatment for 12weeks. The efficacy and side effects were assessed with Yale Brown Obsessive Compulsive Scale( Y - BOCS) and Treatment Emergent Symptom Scale( TESS) before treatment and at the 2nd,4th,8th,12thweekend. Results: The total scores of Y - BOCS decreased significantly at 4thweekend in the singledrug group( P < 0. 05) . The totle scores of Y - BOCS decreased significantly at 2ndweekend in the combined drug group. The total effective rate of the sin-gle drug group was 52. 4% ,the total effective rate of the combined drug group was 68. 1% ,there were significant differences between the two groups( P <0. 05) . Conclusion: Aripiprazole can be used alone to treat obsessive - compulsive disorder,but combined with SSRI has better efficacy.