【关键词】乳腺癌; 乳腺 X 线征象;p53;Ki-67DOI:10.3874/j.issn.1674-1897.2013.04.Z0404Progress ofthe correlation study between mammographic appearances and expression ofp53,Ki-67 in patientswith breast cancer LIU Jie, LIU Peifang. Department of Breast Imaging Diagnosis, Cancer Institute & Hospital of TianjinMedical University, Key Laboratory of Breast Cancer Provention and Therapy of Education Ministry,Key Laboratory ofCancer Prevention and Therapy, Tianjin 300060, China【Abstract】Breast cancer is one of the most common female malignant tumors. The occurrence and development ofbreast cancer are often accompanied by abnormal gene expression. It has been well accepted that p53, Ki -67 are thecommonly used biological indicators for clinical endocrine therapy and prognosis prediction. The oncogene expression reflectsthe malignant biological behavior of breast cancer from different perspectives. Those aggressive behaviors cause a variety ofchanges in histopathology and thus in imaging. Therefore, the imaging features of breast cancer may indirectly demonstratethe status of p53, Ki-67. Until now, because of its facility, low cost and high accuracy, mammography is still the preferredmethod in breast cancer screening and diagnosis. The relationship of mammographic appearances and gene expression inpatients with breast cancer has potential clinical value in preoperative evaluation and planning of non-surgical treatment forthose who are not able to perform immunohistochemistry.【Key words】Breast cancer; Mammographic appearances; p53; Ki-67