PEKING UNI VERSITY( HEALTH SCIENCES) Vol. 46 2014733 交联聚乙烯醇栓塞微球的制备与体外性质 北京大学药学院药剂学系,北京100191) 目的:研究交联聚乙烯醇栓塞微球(polyvinyl alcohol microspheres,PVA-Ms) 的制备方法及其理化性质。 方法:采用乳化化学交联法制备 PVA-Ms,以红外光谱法考察微球交联产物的结构,以光学显微镜观察微球的形态、 测定粒径大小,考察微球的吸水率和溶胀率,以物性测定仪测量微球的弹性,采用创新设计的装置模拟栓塞推注微 球的过程并实时测定推注压力。结果: 红外光谱确证了微球为聚乙烯醇与甲醛的交联产物。制备的 PVA-Ms 整,冻干微球的粒径范围为80 800μm,平均粒径 574. μm;湿微球的粒径范围为100 900μm,平均粒径 602. μm。冻干微球在生理盐水中20 min 内达到吸水平衡,平均吸水率为 175% ,平均溶胀率为 48. 6% 有良好的弹性,可顺利经导管推注,大粒径的微球通过导管的压力较大。结论:PVA-Ms的理化性质可以满足栓塞 治疗的要求,本研究为系统评价栓塞微球的体外性质提供了方法。 [关键词] 栓塞,治疗性;微球体;聚乙烯乙醇;交联试剂 [中图分类号] R944. 23 [文献标志码] [文章编号]1671-167X(2014)05-0733-06doi:10. 3969 issn.1671-167X. 2014. 05. 013 Preparation vitroevaluation crosslinkedpolyvinyl alcohol microspheres embolizationYANG Shen,MENG Wen-jing,LU Xiao-jing,WU Ya-nan,REN ZENG Dun-zhu,FAN Tian-yuan Pharmaceutics,PekingUniversity School PharmaceuticalSciences,Beijing 100191,China) ABSTRACT Objective:To develop properties crosslinked polyvinyl alcohol microspheres embolization.Methods: PVA-Mswere produced emulsionchemical crossl inking method. Fourier tr ansform infrared spect roscopy investigate hespecial functional groups particlesize PVA-Mswere determi ned optical mi croscope; waterabsorpti swelling ratio were also invest iga ted; texture analyz er. newdev ice PVA-Msduring delivery hroughcatheter crosslinking reaction formalde-hyde PVA-Mswere round wi th smooth surface. average diameter lyophilizedPVA-Ms wetPVA-Ms with average ratio waterabsorpti heswell ing ratio 48.6% PVA-Mswere mechanically stable appropriateelast icity delivered through hecatheter without any dif argersize delivered. Conclusion: PVA-Ms prepared clinicalemboli za- ti physicochemicalproperti es. studyprovides properties microspheres systemically embolization vitro.KEY WORDS Embolization,therapeutic; Microspheres; Polyvinyl alcohol; Cross-l inking reagents 血管栓塞术是治疗肿瘤( 如子宫肌瘤、宫颈癌、 肝癌等) 、动静脉畸形、出血等病症的有效手段。