董一珠
, 褚梦真, 张冰, 张晓朦, 林志健, 吴嘉瑞
北京中医药大学中药学院,北京 100029
DONG Yizhu,
, CHU Mengzhen, ZHANG Bing, ZHANG Xiaomeng, LIN Zhijian, WU Jiarui,
School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 100029,China
通信作者 吴嘉瑞(1977-),男,北京人,教授,博士生导师,研究方向:中药上市后再评价。E-mail:exogamy@163.com。
作者简介 董一珠(1995-),女,黑龙江哈尔滨人,在读硕士,研究方向:中药药物警戒与合理用药。ORCID:0000-0002-9676-7374。电话:(0)18801021101,E-mail:15736872291@163.com。
基金资助: 国家自然科学基金资助项目(81673168)
中图分类号:R281.3;R282.71文献标识码:A文章编号:
摘要:
目的通过对《本草纲目》草部有毒中药梳理及研究,总结“识毒-用毒-防毒-解毒”的药物警戒思想,以期为草部有毒中药临床安全合理用药提供重要保障。方法基于Excel 2016提取《本草纲目》(金陵版点校本)草部中药的毒性、性味、炮制、适应证、配伍等情况,应用统计学方法进行分析。结果草部中有毒中药共74种,占草部总数的16.8%。用药部位包括根、茎、叶、花等,共84种,其中大毒药物11种,有毒药物42种,小毒药物29种,微毒药物2种。草部有毒中药入药多为炮制品,并注重配伍减毒。结论《本草纲目》中草部有毒中药药物警戒思想丰富,经验宝贵,值得认真研究挖掘和继承。
关键词:本草纲目 ;草部 ;有毒中药 ;药物警戒
Abstract:
ObjectiveThrough the combing and research of toxic Chinese medicines of grass classification in theCompendium of Materia Medica, the paper summarizethe pharmacovigilance thought of “cognition, application, prevention and rescue of drug toxicity ”, in order to provide important guarantee for the clinical safety and rational use of toxic traditional Chinese medicine.MethodsBased on Excel 2016, the toxicity, property and flavor, processing methods, indications, compatibility of Chinese herbal medicines in theCompendium of Materia Medica (Jinling Edition) were applied to analyze with statistical methods.ResultsThere were 74 kinds of toxic Chinese medicines in the grass classification, accounting for 16.8% of the total number of Chinese herbal medicines in the grass classification. A total of 84 drug-containing parts consisted of roots stems, leaves, flowers including 11 major poisonous drugs, 42 toxic drugs, 29 small posionous drugs and 2 micro-toxic drug. It has been found that the toxic Chinese medicines of grass classification are mostly processed ones, and they focus on compatibility and attenuation.ConclusionThe pharmacovigilance thought and experience of toxic Chinese medicine are effective and valuable,and they are worth exploring and inheriting by us.