Correl ati on of l i thi umtreatm ent andthyroi dfuncti on i npati entsw i thbi pol ardi sordersZH AN GJ i —hua,ZH AN G YongTi anj i n Andi ngHospi tal ,Ti anj i n300222,Chi na【Abstract】O bj ecti veTo determ i ne the correl ati on of l i thumand thyroi d functi on i npati entsw i th bi pol ar di sorder.M ethods65pati entsw i th l i thum treatm ent w ere tested al lpl asm abi om arkers ofthyroi dfuncti onrespecti vel ypoi nt.Resul ts①Therew eresi gni fi cantl yl ow er r13l evel (1.62± 0.34nm ol /L),T4 l evel ( 97.08± 19.81) and hi gherTSH l evel(2.77± 1.27m IU/L)after l i thumtreatm ent thanatthe basel i ne and 3 m onths end-at basel i ne( P<0.01) ;②There w eresi gni fi cant di fference betw een gender afterl i thumtreatm ent,therew erel ow er髓l evel (1.52± 0.37 nm ol /L),and hi gherTSHl evel (3.26± 1.38 m l U/L)i nfem al epati entsthani n m al epati ents(P<O .01);③r11l ecorrel ati on anal ysi s show ed the l i thumtreatm ent m ay be m ai nl y correl ated w i th 1r3l evel (r=0.35,P=0.005) af tercontrol l i ng genderand durati onconfoundi ng.Concl usi onIAthumtreatm entm aybe associ ated w i thchangi ng thyroi dfuncti on i n pati ents w i th bi pol ar di sorder.【Key w ords】Bi pol ar D i sorder;Li thum ;Thyroi dFuncti on