谢忠建1
, 程群2, 丁悦3
1. 410011 长沙,中南大学代谢内分泌研究所,中南大学湘雅二医院代谢内分泌科;
2. 200040 上海,复旦大学附属华东医院骨质疏松科;
3. 510120 广州,中山大学孙逸仙纪念医院骨外科
基金项目:国家自然科学基金(81471055,81672646)
摘要:人体内的维生素D主要在皮肤合成,少量从食物中摄取。维生素D在肝脏首先被转变为25-羟维生素D,这个转变过程受25-羟化酶的催化,然后在肾脏被转变为高活性的1,25-双羟维生素D,这个转变过程受25羟维生素D-1α-羟化酶的催化。1,25-双羟维生素D的经典作用为促进肠道钙和磷的吸收和肾小管内钙的重吸收,还通过直接调节骨骼代谢,以维持血液循环中的钙磷稳态。非经典作用包括对机体多种组织细胞增生、分化和功能的调节。
关键词:维生素D25-羟维生素D1, 25-双羟维生素D代谢作用
Metabolism and functions of vitamin D
XIE Zhong-jian1
, CHENG Qun2, DING Yue3
1. Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha 410011, China;
2. Department of Osteoporosis and Bone Disease, Huadong Hospital, Fudan University, Shanghai 200040, China;
3. Department of Orthopaedics, Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China
Abstract:Vitamin D made by the action of sunlight on the skin accounts for majority of the body's supply, but lower levels of vitamin D can also be obtai