(生物谷Bioon.com)
PMC:
PMID:
Slower Postnatal Growth Is Associated with Delayed Cerebral Cortical Maturation in Preterm Newborns
Jillian Vinall1,2, Ruth E. Grunau1,2,3,4, Rollin Brant2,5, Vann Chau2,3,4, Kenneth J. Poskitt2,3,6, Anne R. Synnes2,3,4 and Steven P. Miller2,3,7,*
Slower postnatal growth is an important predictor of adverse neurodevelopmental outcomes in infants born preterm. However, the relationship between postnatal growth and cortical development remains largely unknown. Therefore, we examined the association between neonatal growth and diffusion tensor imaging measures of microstructural cortical development in infants born very preterm. Participants were 95 neonates born between 24 and 32 weeks gestational age studied twice with diffusion tensor imaging: scan 1 at a median of 32.1 weeks (interquartile range, 30.4 to 33.6) and scan 2 at a median of 40.3 weeks (interquartile range, 38.7 to 42.7). Fractional anisotropy and eigenvalues were recorded from 15 an