GO term的结构
所有的GO terms之间都存在着相互关系,它们的关系可以用有向无环图(DAG,Directed Acyclic Graph)来说明,DAG图就能够明确地表示出不同GO term之间的关系,它们之间的关系有很多种,例如is_a,part_of,regulates,has part,negatively regulates和positively regulates。除了根节点(例如CC,BP,MF这些节点)外,其余的GO terms都与其它的GO terms都有一定的亚类关系,例如GO:0015758(葡萄糖运输,glucose transport)is aGO:0015749单糖转运(monosaccharide transport)的一个亚类。其他的关系还有GO:0031966: mitochondrial membranepart ofGO:0005740: mitochondrial envelope,GO:0006916: anti-apoptosisregulatesGO:0012501: programmed cell death。
一个典型的GO term内容如下所示(通过QuickGO查询):
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Accession
GO:0005515
Name
protein binding
Ontology
molecular_function
Synonyms
protein amino acid binding, glycoprotein binding
Alternate IDs
GO:0045308, GO:0001948
Definition
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may