关键词 　 阴茎海绵体 ;结构 ;功能 ;隐匿阴茎 ;大鼠中图分类号 　R698+. 1 　 文献标识码 　 A 　 文章编号 　 167128852(2008) 0120067203Changes of Structure and Function in Corpus Cavernosumof Rats with Concealed PenisYU Weimin , CHENG Fan , ZHANG Xiaobin , LIU Xiuheng, XIA Yue , HU ZhixiongDept. of Urology , Renmin Hospital of Wuhan University , Wuhan 430060 , ChinaAbstractObjective : To explore the effects of concealed penis on the structure and function of the cor2pus cavernosum in rats. Methods : A total of 240 rats were equally divided into three groups for2 , 4 and 6 months study respectively. The experimental models of concealed penis were estab2lished by intra2pocket2suture of the root of penis. Each group was divided into buried group ,sham operation group , and normal control group. Masson staining in combination with computerimage analysis was used to determine the contents of tissue in the corpus cavernosum. The effectof penis buried on function was judged by detecting NO synthase (NOS) activity of the corpuscavernosum. Results : In the buried group , the arrangement of the tissue had become irregularity ,when compared with normal and control group in each experimental stage. Penis buried resultedin decreasing of smooth muscle content when compared with normal after four and six months(both P < 0. 05) and increasing of fibrous connective tissue content after six months( P < 0. 05) . Inburied group , the NOS activity decreased in four and six months group when compared with nor2mal group ( P < 0. 05 and P < 0. 01 , respectively) . Conclusion : Buried penis has effects on struc2ture and function of the corpus covernosum , and it is positively correlated with the course of bur2ied penis.Key Words 　 Corpus Cavernosum ; Structure ; Function ; Concealed Penis ; Rats 武汉大学学报 (医学版)