麻醉药盐酸赛拉嗪对犬肝肾功能的影响贺绍君,李静,蔡锡英,刘德义(安徽科技学院动物科学学院,安徽 凤阳 233100)摘要: 旨在研究临床上常用麻醉药盐酸赛拉嗪对犬肝肾功能指标的影响。选择成年健康杂种犬 8 只,按常规推荐剂量 2. 4 mg/kg 体重股四头肌注射盐酸塞拉嗪进行麻醉。分别在麻醉前、麻醉后 0. 5 h、1 h、1. 5 h、2 h、24 h、48 h、72 h 颈静脉采血 2 mL,分离血清。采用全自动生化分析仪检测血清肝肾功能相关指标。结果显示,与试验开始相比,各试验采血点血清天门冬氨酸氨基转移酶和 γ - 谷氨酰转移酶的活性及血清总蛋白、直接胆红素、肌酐、尿酸、尿素氮的含量均无显著变化 (P>0. 05)。各试验采血点之间相比,肝肾功能指标无显著性差异 (P>0. 05)。研究结果说明,盐酸赛拉嗪用于犬麻醉时对其肝肾功能均无明显影响。关键词: 盐酸赛拉嗪;犬;肝功能、肾功能中图分类号:S829. 2 文献标志码:B文章编号:0529-5130(2017)11-0105-04Effects of xylazine hydrochloride on liver and renal functionsin dogs during anesthesiaHE Shaojun,LI Jing,CAI Xiying,LIU Deyi(College of Animal Science,Anhui Science and Technology University,Fengyang 233100,China)Abstracts: To investigate the effects of xylazine hydrochloride on the liver and renal function in dogs during anesthesia,eight healthy adulthybrid dogs were anesthetized by quadriceps injection of xylazine hydrochloride at a dose of 2. 4 mg/kg body weight. The blood samples werecollected from jugular vein at 0 min before anesthesia and 0. 5 h,1 h,1. 5 h and 2 h after anesthesia. The serum indicators associated withliver and renal functions were measured by automatic biochemical analyzer. These results showed that the activities of serum aspartate amin-otransferase and γ -glutamyltransferase and the serum contents of total protein,direct bilirubin,creatinine,uric acid and urea were not sig-nificantly changed (P>0. 05)when compared with the starting point. Also,there was no significant difference in liver and kidney functionsamong the different experimental blood collection points (P>0. 05). It suggests that xylazine hydrochloride has no significant effect on liverand renal functions in dogs during anesthesia.Key words: xylazine hydrochloride;anesthesia;dogs;liver function;renal function