结果:贲门癌组血清CEA 的阳性率明显高于CA72-4,CAl9-9。含CEA的两项联合检测可使检测的阳性率明显提高,且两种联合检测 有明显差异,3者联合检测阳性率可达66.7%。胃窦癌组3种血清肿瘤标志物单独检测时的阳性率无明显 差异,联合检测CEA和CA72-4或CAl9—9可使检测的阳性率有所提高,3者联合检测阳性率可达57.4%。 结论:血清CEA、cA72_4、CAl9-9水平在贲门癌及胃窦癌的诊断有一定意义,阳性率与肿瘤的部位有关,联 检可提高胃癌尤其是贲门癌的诊断阳性率。 关键词:癌胚抗原;糖类抗原19—9;糖类抗原72-4;贲门癌;胃窦癌 中图分类号:R 735.2 文献标识码:B doi:10.3969/j.issn.1004437X2012.01.015 Prognostic value of serum tumor markers level in cardiac er canc? and distal gastric cancer MA Feil,HUA Ya.wei2,ZHANG Zhan.don92,LU Min93,ZHANG Yong.1ei‘,XU Jia—lian91 (J.The First Affiliated Hospital ofZhengzhou University,Zhengzhou 450052,China;2.Henan Tumor Hospital,Zhengzhou 450008 China;3.Boai County People’s Hospital,Boai 454450,China) Abstract:Objective:To discuss bohydrate antigen(CA)724 ods:236 gastric 2009 to cancer prognostic value of serum carcinoembryonie cancer antigen(CEA),car- and CA 19-9 levels in cardia were and distal gastric cancer.Meth- patients analysed through retrospective analysis,whom from march november 20 1 0 in general surgery department of henan tumor hospital,and 200 healthy as subjects control group.Results:The套ositiVe rate of serum CEA is significant higher than the others.Including CEA could improve Diagnosis of positive,there is significant deviation between two combinations.while positive rate in combination of three serum markers 66.7%.There is cancer no significant deviation of serum CEA,CA72-4,CAl9?9 in distal gastric of CEA and CA72-4 or group,the combination rate CAl9-9 could improve positive rate,while positive in combination of three serum markers 54.7%.Conclusion:The serum CEA。CA72-4 and CA 19.9 levels will cont. 收稿日期:2011?11-02;修订日期:201l一11—14 作者简介:马飞(1986一),男,河南襄城人,在读硕士研究生,研 究方向:胃肠道肿瘤。 通讯作者:花亚伟(1965一),男,主任医师,E—mail:yaweihua@ ?42 万方数据 第1期 马 飞等:血清肿瘤标志物检测在贲门癌及胃窦癌诊断中的价值 ribute to the prognosis in.gastric cancer,positive rate is concerned with tumor position,while combi- cancer. nation could improve Positie diagnosis in gastric cancer,especially in cardiac Keywords:CEA;CAl9—9;CA72-4;gastric cancer;cardiac cancer 胃癌是全球第四大恶性肿瘤,在亚洲是肿瘤致死 的第二大病因…,且大多数确诊时已是中晚期心],提 高诊断水平,是治疗胃癌的关键。