龙源期刊网 http://www.qikan.com.cn 卡泊三醇软膏联合复方丙酸氯倍他索软膏治 疗斑块状银屑病疗效观察 作者:李明鑫 李波 来源:《中国现代医生》2011 年第 32 期 [摘要]目的 观察卡泊三醇软膏及复方丙酸氯倍他索软膏治疗斑块状银屑病的疗效及安全 性。方法 选择门诊斑块状寻常型银屑病患者 96 例,随机分治疗组及对照组各 48 例,治疗组 每日卡泊三醇软膏及复方丙酸氯倍他索软膏早晚交替使用;对照组每日卡泊三醇乳膏及卤米松 乳膏早晚交替使用,治疗前及治疗后第 2、4、8 周观察皮损面积及严重度指数(PASI 评分) 判定疗效指数,根据不良反应判定其安全性。结果 经过 8 周观察,治疗组有效率 95.8%,对照 组有效率 81.3%。治疗组 3 例出现不良反应,对照组 6 例出现不良反应,症状轻微,患者均可 耐受。结论 卡泊三醇和复方丙酸氯倍他索交替使用治疗斑块状银屑病见效快,不良反应轻 微,可作为外用药联合使用选择方案之一。 [关键词] 寻常型银屑病;斑块状;卡泊三醇软膏;复方丙酸氯倍他索软膏 [中图分类号] R758.63 [文献标识码] B [文章编号] 1673-9701(2011)32-62-02 The Treatment Efficacy of Plaque Type Psoriasis Vulgaris Using Calcipotriol Cream Combined with Compound Clobetasol Propionate Ointment LI Mingxin LI Bo Dalian Dermatosis Hospital , Dalian116021, China [Abstact] Objective To observe the efficacy and safety of treatment in plaque type psoriasis vulgaris using calcipotriol cream combined with compound clobetasol propionate ointment. Methods There were 96 patients of plaque type psoriasis vulgaris and were randomly divided into two groups: treatment group used calcipotriol cream combined with compound clobetasol propionate ointment sequentially, control group used calcipotriol cream combined with halometasone cream sequentially. The PASI scores were evaluated at the beginning of treatment and at week 2, 4 and 8 after the initiation. Results After 8 weeks treatment, the efficacy of treatment group was 95.8%, and 81.3% in control group. The incidence of adverse reactions in treatment group was less than that in control group. Conclusion There are advantages of treatment in plaque type psoriasis vulgaris using calcipotriol cream combined with compound clobetasol propionate ointment : rapid and good response, as well as less adverse reactions. 龙源期刊网 http://www.qikan.com.cn [Key words] Psoriasis vulgaris ;Plaque type ;Calcipotriol cream ;Compound clobetasol propionate ointment 寻常型银屑病是一种常见的慢性复发性炎症性皮肤病,临床上皮损反复发作后易形成暗红 色肥厚性斑块,经久不退,严重影响患者的生活质量。