结论:　ZOL　在体外可能通过抑制　NF-κB　和JNK　信号通路来抑制破骨细胞形成和骨吸收功能,是治疗如　骨质疏松症类的破骨细胞相关疾病的潜在药物。　【关键词】　破骨细胞;ZOL;RANKL;骨吸收;信号通路　Accessary　canals　of　the　canalis　sinuosus:　a　prevalent　but　often　overlooked　anatomical　variation　in　the　anterior　maxilla　单钿钿　曲杨古丽莎　中山大学附属口腔医院　【　摘要】　Accessary　boney　canals　(ACs)　communicating　with　the　canalis　sinuosus　(CS),　a　boney　canal　carrying　the　anterior　superior　alveolar　nerve　and　vessels,　can　often　be　present　but　overlooked　in　the　anterior　maxilla.　This　anatomic　variation　has　been　considered　as　a　hidden　threat　to　neurovascular　complications　resulting　from　implant　placement　in　this　region.　Injuries　to　the　ACs　can　cause　haemorrhage,　temporary　or　permanent　paresthesia　as　well　as　non-integration　of　dental　implants.　The　objective　of　this　study　was　to　verify　the　characteristic　parameters　of　the　ACs　and　their　relationship　to　the　terminal　CS,　anterior　maxilla　and　anthropometric　parameters.　Radiographic　measurements　were　taken　on　1007　cone-beam　computed　tomography　scans　from　Mongolian