结论:
有标准推荐的时间间隔(0,1-2,6个月)如果不按推荐的时间间隔注射,可以延后,不能提前(规定的都是最小间隔时间)一般来讲不需要做抗体检测,因为都会产生抗体
详细来讲,根据HPV Vaccine Information for Clinicians的说明:
1. 有标准推荐的时间间隔(0,1-2,6个月)
If the first dose of any HPV vaccine is given on or after the 15th birthday, vaccination should be completed according to a 3-dose schedule. In a 3-dose series, the second dose is recommended 1–2 months after the first dose, and the third dose is recommended 6 months after the first dose (0, 1–2, 6 month schedule).
如果在 15 岁生日或之后进行第一剂 HPV 疫苗,应该根据 3 剂量的计划完成疫苗接种。在3剂量系列中,建议在第一剂量 1-2 个月后进行第二次剂量注射,第一剂量后 6 个月推荐注射第三剂量(时间表为:0,1-2,6个月)。
In a 3-dose schedule of HPV vaccine, the minimum intervals are 4 weeks between the first and second dose, 12 weeks between the second and third dose, and 5 months between the first and third dose. If a vaccine dose is administered at a shorter interval, it should be re-administered after another minimum interval has been met since the most recent dose. If the third was administered on or be