实用妇产科杂志 2013 年 8 月 第 29 卷第 8 期Journal of Practical Obstetrics and Gynecology 2013 Aug. Vol. 29,No. 8基金项目 : 温州市科技局资助项目 ( 编号: Y20070099)文章编号:1003-6946( 2013) 08-603-04可溶性酪氨酸激酶受体 1 /胎盘生长因子比值在子痫前期诊断中的价值朱丽丹1,江明华1,张小芬1,李仁良2,夏淑琦2( 1. 温州医学院附属第二医院,浙江 温州 325000;2. 浙江省温州市第三人民医院,浙江 温州 325000)【摘要】痫前期的诊断价值。 方法: 检测及比较分析 40 例正常孕妇、38 例轻度子痫前期与 32 例重度子痫前期孕妇血清及尿液中 PLGF、sFlt-1 及 sFlt-1 /PLGF 比值的变化, 将尿液 PLGF、sFlt-1 分别 与血清 PLGF、sFlt-1 进行 Person 相关分析,并用 ROC 曲线分析血清、尿液中 sFlt-1 /PLGF 比值对子痫前期的诊断价值。 结果: 轻度子痫前期组血清、 尿液 sFlt-1 /PLGF 比值高于正常对照组, 重度子痫前期组 sFlt-1 /PLGF 比值高于轻度子痫前期组, 各组之间 的 差异均 有统计学意义( 均 P<0. 01) ;尿液 PLGF、 sFlt-1 分别 与 血清 PLGF、 sFlt-1 具有正相关性( r = 0. 692, r = 0. 784, 均 P<0. 05) ;血清、尿液 sFlt-1 /PLGF 比值对轻度子痫前期的 ROC 曲线下面积( AUC) 分别 为 0. 921、0. 935,血清、尿液 sFlt-1 /PLGF 比值对重度子痫前期的 ROC 的 AUC 分别为 0. 959、0. 972。 血清中 sFlt-1 /PLGF 比值的 AUC 与 尿液中 sFlt-1 /PLGF 比值的 AUC 相比差异均 无统计学意义( 均P>0. 05) 。 结论: 血清、尿液 sFlt-1 /PLGF 比值在子痫前期患者中均有明 显的升高, 其为 子痫前期的诊断提供了 一个较理想的 实验室指标, 在临床中 可以 用 尿液 sFlt-1 /PLGF 比值替代血液sFlt-1 /PLGF 比值。子痫前期;胎盘生长因子;可溶性酪酸激酶受体 1目的: 探讨血清、尿液可溶性酪氨酸激酶受体 1 /胎盘生长因子( sFlt-1 /PLGF) 比值在子【关键词】中图分类号:R714. 24+4文献标识码:ADiagnostic Value of Soluble Tyrosine Kinase Receptor 1 /Placental Growth Factorin PreeclampsiaZHU Lidan,JIANG Minghua,Zhang Xiaofeng,et al( The Second Affiliated Hospital of Wenzhou Medical College,Wenzhou Zhejiang 325000,China)【Abstract】Objective:To explore the diagnostic value of serum and urine sFlt -1 /PLGF in preeclampsia. Methods:En-zyme linked immunosorbentassay method was used to detect the levels of PLGF、sFlt-1 in serum and urine of 40 normalpregnant women( control group) ,38 patients with mild preeclampsia( mild preeclampsia group) and 32 patients with se-vere preeclampsia( severe preeclampsia group) . The level of sFlt-1, PLGF and ratio of sFlt-1 /PLGF were compared a-mong the three groups. The correlations between levels of PLGF, sFlt-1 in serum with levels of PLGF, sFlt-1 in urinewere analyzed,The diagnosis value of the ratio of sFlt-1 /PLGF in serum and urine for preeclampsia was also analyzed.Results:Ratios of sFlt -1 / PLGF in serum and urine in mild preeclampsia group were significantly higher than those incontrol group,ratios of sFlt -1 / PLGF in serum and urine in severe preeclampsia group were significantly higher thanthose in mild preeclampsia group( P<0. 01) . There were positive correlations between the levels of PLGF、sFlt-1 in urinewith those in serum( r= 0. 692 and 0. 784, respectively, both P<0. 05) ; The area under the curve( AUC) of the ROCcurve of sFlt-1 /PLGF ratio in serum and urine for mild preeclampsia diagnosis was 0. 921 and 0. 935 respectively; TheAUC of the ROC curve of sFlt-1 /PLGF ratio in serum and urine for severe preeclampsia diagnosis was 0. 959 and 0. 972respectively. There was no significant difference on AUC of sFlt-1 /PLGF ratio between in serum and that in urine. Con-clusions:The ratios of sFlt-1 /PLGF in patients with preeclampsia in serum and urine were significantly elevated, whichmaybe an ideal index for the diagnosis of preeclampsia. The ratio of sFl-1 /PLGF in urine can be used to replace that inserum in the diagnosis of preeclampsia.·306· 实用妇产科杂志 2013 年 8 月 第 29 卷第 8 期Journal of Practical Obstetrics and Gynecology 2013 Aug. Vol. 29,No. 8【Key words】Preeclampsia;Placental growth factor;Soluble tyrosine kinase receptor 1