October 20, 2008

Oragenics, Inc. DBA ONI Biopharma Inc.
13700 Progress Blvd.
Alachua, Florida 32615

Gentlemen:

We are pleased to advise you that Signature Bank (the “Bank”) holds available
for the use of Oragenics, Inc. DBA ONI Biopharma, Inc. (the “Borrower”) a line
of credit in the amount of $1,000,000.00 upon the following terms and
conditions:

1. Facility. (a) A line of credit (the “Line”) for short-term loans for working
capital purposes (“Loans”), provided that the aggregate principal amount of
Loans at any time outstanding shall not exceed $1,000,000.00.
 
(b) Loans shall be extended upon the Borrower’s prior written notice to the Bank
(duly executed by an authorized officer of the Borrower) such notice to be in a
form satisfactory to the Bank which may be accomplished by facsimile
transmission or other digitally or electronically scanned media delivered by
internet electronic mail transmission.
 
2. Credit Period. The Line shall be available for the period commencing with the
date of the Borrower’s acceptance and satisfaction of the terms hereof and
ending October___, 2009 (the “Credit Period”). All Loans shall mature on the
last day of the Credit Period.
 
3. Interest and Fees. The Bank shall charge and shall be entitled to receive the
following (which amounts, together with any other amounts owing by the Borrower
to the Bank, may be charged to any demand deposit account maintained by the
Borrower with the Bank):
 
(a) Loans shall be further subject to the terms and conditions of the promissory
note dated the date hereof and executed in connection with the Line (the
“Note”), and shall bear interest at a fluctuating rate per annum equal to the
Prime Rate (as defined in the Note) per annum, which rate will change when and
as the Prime Rate changes. Interest shall be computed on the basis of a 360-day
year for actual days elapsed and shall be payable as set forth in the Note.
 
 
 

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(b) As additional compensation for the Line, the Borrower agrees to pay the Bank
a facility fee in the amount of $10,000.00. Such fee shall be payable upon the
Borrower’s acceptance of the terms and conditions hereof.
 
(c) The Borrower shall pay all fees and expenses of the Bank’s outside counsel
with respect to its preparation and negotiation of the documents to be executed
in connection with the Line to the extent that such fees are in excess of
$5,000.00
 
4. Collateral. All obligations of the Borrower to the Bank shall be fully cash
secured by Signature Bank Fidelity Prime Fund money market account number
_______________ in the name of the Borrower in the amount of $1,000,000.00.
 
5. Other Conditions and Covenants. In addition to the foregoing, at all times
during the Credit Period and as long as any Loan remains outstanding, the
Borrower shall:
 
(a) Furnish to the Bank:
 
(i) within 150 days of the close of each fiscal year of the Borrower throughout
the Credit Period, the consolidated and consolidating balance sheet, statements
of income and retained earnings and cash flows of the Borrower and its
subsidiaries as of the last day of and for such fiscal year, each such statement
to be prepared in accordance with generally accepted accounting principles
(“GAAP”) consistently applied by a firm of independent certified public
accountants satisfactory to the Bank;
 
(ii) annually, and not later 150 days after the close of each fiscal year of the
Borrower throughout the Credit Period, tax returns of the Borrower; and
 
(iii) such other statements and reports as shall be reasonably requested by the
Bank.
 
(b) not enter into any merger or consolidation or liquidate, windup or dissolve
itself or sell, transfer or lease or otherwise dispose of all or any substantial
part of its assets or acquire the capital stock or assets of any other business;
 
(c) maintain a depository relationship with the Bank.
 
6. Events of Default. Upon the occurrence of any of the following events (each
an “Event of Default” and collectively the “Events of Default”):
 
(a) default by the Borrower in making any payment of principal, interest, or any
other sum payable under this Letter Agreement or the Note when due; or
 
 
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(b) default by the Borrower in the due payment of any other obligation owing to
the Bank; or
 
(c) the Borrower failing to perform any condition or obligation described in
this agreement or in any other agreement, document or instrument executed and
delivered pursuant to or in connection with this agreement within the time
periods specified;
 
(d) the Borrower defaulting under any agreement, document or instrument executed
and delivered pursuant to or in connection with this agreement (whether executed
prior or subsequent to the date hereof) or in connection with any obligation
then outstanding with the Bank;
 
(e) default by Borrower in the due payment of any other indebtedness for
borrowed money or default in the observance or performance of any covenant or
condition contained in any agreement or instrument evidencing, securing, or
relating to any such indebtedness, which causes or permits the acceleration of
the maturity thereof; or
 
(f) any representation or warranty made by the Borrower herein, in the Note or
in any certificate furnished by the Borrower in connection with the extensions
of credit made or to be made to the Borrower by the Bank, proves untrue in any
material respect; or
 
(g) if the Borrower becomes insolvent or bankrupt, is generally not paying its
debts as they become due, or makes an assignment for the benefit of creditors,
or a trustee or receiver is appointed for the Borrower or for the greater part
of the properties of the Borrower with the consent of the Borrower, or if
appointed without the consent of the Borrower, such trustee or receiver is not
discharged within 90 days, or bankruptcy, reorganization, liquidation or similar
proceedings are instituted by or against the Borrower under the laws of any
jurisdiction, and if instituted against the Borrower are consented to by it or
remain undismissed for 90 days, or a writ or warrant of attachment or similar
process shall be issued against a substantial part of the property of the
Borrower and shall not be released or bonded within 90 days after levy; or
 
(h) if any information furnished or provided by the Borrower to the Bank is not
materially correct; or
 
(i) if the usual credit factors do not remain favorable with respect to the
Borrower in the sole determination of the Bank or one or more conditions exist
or events occur which have resulted or may result in a material adverse change
in the business, properties or financial condition of the Borrower as determined
in the sole discretion of the Bank or one or more other conditions exist or
events occur which the Bank deems materially adverse;
 
 
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then, in any such event, any or all of the following actions may be taken: The
Bank may in its sole discretion and without presentment, demand, protest or
notice to the Borrower, all of which are hereby waived, (i) declare all Loans
and all indebtedness, obligations and liabilities owing in connection therewith
due and payable and the same shall forthwith become due and payable without
presentment, demand, protest or notice, (ii) curtail or eliminate the Line
and/or any or all of the Loans, and (iii) take whatever other action it shall
deem appropriate as permitted by applicable law or by any agreement, document or
instrument executed and delivered pursuant to or in connection with the Line.

7. Conditions Precedent. The Bank reserves the right to terminate its
obligations hereunder after acceptance thereof by the Borrower, and the Bank
shall be under no obligation to extend any Loan hereunder, unless and until the
satisfaction of each of the additional following events:
 
(a) The Bank shall have received (i) copies of the resolutions of the board of
directors of the Borrower (or similar governing body if the Borrower is not a
corporation) authorizing the execution, delivery and performance of this Letter
Agreement and the agreements, instruments and documents executed pursuant to or
in connection with the Line certified by the Secretary or an Assistant Secretary
of the Borrower; (ii) a certificate of the Secretary or an Assistant Secretary
of the Borrower certifying the names and true signatures of the officers of the
Borrower authorized to sign any and all documents to be delivered by the
Borrower or as required or contemplated hereunder; and (iii) a copy of the
organizational documents of the Borrower, with all amendments thereto and a
certificate of good standing issued by the State of the Borrower’s organization.
 
(b) There shall have been executed documentation acceptable to the Bank and its
counsel, including without limitation the Note and pledge agreement.
 
(c) The Bank shall have received a satisfactory opinion letter from Borrower’s
counsel in the form annexed hereto as Exhibit “A”.
 
(d) The Bank shall have received (i) the results of searches of Uniform
Commercial Code and other lien filings with respect to the Borrower in the State
of Florida and such searches shall disclose no liens on the collateral for the
Loan;
 
(e) The Borrower’s $75,000.00 BRLOC with the Bank shall be paid in full; and
 
(f) All other documents and legal matters in connection with the transactions
contemplated by this Letter Agreement shall be satisfactory in form and
substance to the Bank and its counsel and the Bank and its counsel to be
satisfied as to all legal matters.
 
 
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8. Successors and Assigns. This Agreement shall be binding upon and inure to the
benefit of the Borrower and the Bank and their respective successors and
assigns, except that the Borrower may not assign or transfer any of its rights
under this Agreement without the prior written consent of the Bank. The term
“Bank” as used herein shall be deemed to include the Bank and its successors,
endorsees and assigns.
 
9. Governing Law. This Letter Agreement and each extension of credit hereunder
shall be governed by and construed in accordance with the laws of the State of
New York (excluding the laws applicable to conflicts or choice of law) and the
Borrower hereby submits to the jurisdiction of the United States federal courts
and the courts of the State of New York located in any county or city as
selected by the Bank within the State of New York.
 
10. Pledge to Federal Reserve. The Bank may at any time pledge all or any
portion of its rights under any note executed pursuant to this Letter Agreement
and the loan documents executed in connection therewith to any of the twelve
(12) Federal Reserve Banks organized under Section 4 of the Federal Reserve Act,
12 U.S.C. Section 341. No such pledge or enforcement thereof shall release the
Bank from its obligations under any of such loan documents.
 
11. Acceptance. If the foregoing is acceptable, please have the enclosed copy of
this letter signed by a duly authorized signer of the Borrower in the space
provided below and returned to the Bank together with payment of the facility
fee on or before October__, 2008. This letter shall be of no force or effect and
shall be unenforceable against the Bank unless signed and returned to the Bank
by such date.
 
 

 
Very truly yours,
 
SIGNATURE BANK
 
By:/s/ Joseph Festa                                                
Name: Joseph Festa
Title: Group Director and Senior Vice President

 
 
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ACCEPTED AND AGREED
this 20th day of October, 2008:

BORROWER:

ORAGENICS, INC. DBA ONI BIOPHARMA INC.
 
By:/s/David Hirsch                                                    
Name: David Hirsch
Title: CFO-COO
 
 
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EXHIBIT “A”

FORM OF OPINION LETTER
 

 
October ___, 2008

 
Signature Bank
565 Fifth Avenue
New York, New York 10017

Re:
Line of Credit Letter Agreement (the “Credit Agreement”) dated as of October
___, 2008, by and between Oragenics, Inc., a Florida corporation (“Borrower”)
and Signature Bank (the "Lender")  

 
Ladies and Gentlemen:

We have acted as legal counsel to Borrower in connection with the execution and
delivery by Borrower of the Credit Agreement, with the Lender and the other
Financing Documents (as such term is defined below). This opinion is delivered
to you with the consent of the Borrower.

In connection with the opinions expressed herein, we have examined such
documents, records and matters of law as we have deemed necessary for the
purposes of this opinion. We have examined, among other documents, the
following:

 
(a)
the Credit Agreement;

 
(b)
the Promissory Note (the “Note”) dated October ___, 2008, in the principal
amount of $1,000,000.00, made by Borrower and payable to the order of Lender;

 
(c)
the Pledge Agreement (the “Pledge Agreement”) dated October ___, 2008, between
Borrower and Lender;

 
(d)
the Amended and Restated Articles of Incorporation of Borrower as filed with the
Florida Department of State on May 8, 2002;

 
(e)
the Bylaws of Borrower;

 
(f)
a Certificate of Status relating to Borrower issued by the Florida Department of
State on October 7, 2008;

 
(g)
a copy of the Action Taken by Unanimous Written Consent in Lieu of a Meeting of
the Board of Directors of the Borrower authorizing the loan transaction.

 
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The documents referred to in items (a) through (c) above, inclusive, are
referred to herein collectively as the "Financing Documents"; and the documents
referred to in items (a) through (g) above, inclusive, are referred to herein
collectively as the "Documents".

In all such examinations, we have assumed the legal capacity of all natural
persons executing documents, the genuineness of all signatures of Persons other
than the Borrower or those signing on behalf of the Borrower, the authenticity
of original and certified documents and the conformity to authentic original or
certified copies of all copies submitted to us as conformed or reproduction
copies. As to various questions of fact relevant to the opinions expressed
herein, we have relied upon, and assume the accuracy of, representations and
warranties contained in the Documents and certificates and oral or written
statements and other information of or from representatives of the Borrower and
others and assume compliance on the part of all parties to the Financing
Documents with their covenants and agreements contained therein. As to the
factual matters set forth therein, and, with respect to the opinions expressed
in paragraph 1 below, as to the legal conclusions expressed therein, we have
relied solely upon certificates of public officials.

To the extent it may be relevant to the opinions expressed herein, we have
assumed that all parties to the Financing Documents other than the Borrower are
duly organized, validly existing and in good standing under the laws of their
respective jurisdictions of formation and, to the extent relevant, are duly
qualified as foreign corporations and authorized to transact business in all
relevant jurisdictions, have the legal authority and power to enter into and
perform such documents and to consummate the transactions contemplated by the
Financing Documents, that such documents have been duly authorized, executed and
delivered by all of the parties to the Financing Documents other than the
Borrower and constitute legal, valid and binding obligations of all of the
parties to the Financing Documents other than the Borrower, and that the Lender
complies with all standards of conduct applicable to it with respect to the
Financing Documents (including, without limitation, any requirement that the
Lender act reasonably, in good faith, in a commercially reasonable manner or
otherwise in compliance with, and not in violation of, applicable law).
Furthermore, in rendering the opinions expressed herein, we have assumed, and we
express no opinion as to, compliance by the Lender with any state, federal or
other laws or regulations applicable to it or to the legal or regulatory status
or the nature of the business of the Lender.

To the extent it may be relevant to the opinions expressed herein, we have
assumed that the execution and delivery of the Financing Documents by the
parties thereto other than the Borrower and the performance by the parties
thereto other than the Borrower of their respective obligations under the
Financing Documents do not and will not violate, conflict with, or cause a
default under (a) any law applicable thereto or (b) the Organizational Documents
of any such party.

 
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We have further assumed the following in rendering this opinion:

(1) that there have been no undisclosed modifications of any provision of any
document reviewed by us in connection with the rendering of this opinion and no
undisclosed prior waiver of any right or remedy contained in any of the
Financing Documents;

(2) the truthfulness of each statement as to all factual matters otherwise not
known to us to be untruthful contained in any document;

(3) the accuracy on the date hereof as well as on the date stated in all
governmental certifications of each statement as to each factual matter
contained in such governmental certifications;

(4) that the addressee has acted in good faith, without notice of adverse
claims, and has complied with all laws applicable to it that affect the
transaction evidenced by the Transaction Documents;

(5) that the transaction evidenced by the Financing Documents complies with all
tests of good faith, fairness, and conscionablity required by law;

(6) that routine procedural matters such as service of process or qualification
to do business in the relevant jurisdictions will be satisfied by the parties
seeking to enforce the Financing Documents;

(7) that all statutes, judicial and administrative decisions, and rules and
regulations of governmental agencies constituting the law for which we are
assuming responsibility are published or otherwise generally accessible in each
case in a manner generally available to lawyers practicing in the State of
Florida;

(8) that other agreements related to the transaction evidenced by the Financing
Documents will be enforced as written;

(9) that there are no other agreements or understandings among the parties to
the Financing Documents that would modify the terms of the Financing Documents
or the respective rights or obligations of the parties to those documents;

(10) that with respect to the Financing Documents and the transaction evidenced
thereby, there has been no mutual mistake of fact and there exists no fraud or
duress; and

 
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(11) the constitutionality and validity of all relevant laws, regulations and
agency actions unless a reported case has otherwise held or widespread concern
has been expressed by commentators as reflected in materials which lawyers
routinely consult.
 
For the purposes of this opinion, the following terms shall have the meanings
set forth below:

“Organizational Documents” shall mean, as to any Person which is not a natural
person, the documents and/or instruments creating and/or governing the formation
or operation of such Person, including without limitation such documents
required to be filed with any governmental authority having jurisdiction over
the creation or formation of such Person and including without limitation,
articles of incorporation, bylaws, shareholder agreements, voting trust
agreements, articles of organization, operating agreements, management
agreements, certificates of limited partnership, partnership agreements,
statements of qualification, trust agreements or indentures or other agreements
or instruments as appropriate for such Person.

“Person” shall mean any entity, whether an individual, trustee, corporation,
partnership, trust, unincorporated organization, governmental authority or
otherwise.

Based upon the foregoing, and subject to the limitations, qualifications and
assumptions set forth herein, we are of the opinion that:

1. Borrower is a corporation, duly formed and validly existing under the laws of
the State of Florida, with its status as active, and is otherwise duly qualified
to do business in the State of Florida.

2. Borrower has the power and authority to execute and deliver the Financing
Documents to which it is a party and to perform its obligations under such
Financing Documents. Borrower has taken all necessary action to authorize the
execution, delivery and performance of the Financing Documents to which it is a
party.

3. Each of the Financing Documents to which Borrower is a party has been duly
executed and delivered by Borrower.

4. Neither the execution and delivery by Borrower of the Financing Documents to
which Borrower is a party, nor the performance by Borrower of its obligations
under the Financing Documents to which Borrower is a party, will (a) violate any
law, rule or regulation applicable to the Borrower or (b) violate any provision
of the Organizational Documents of the Borrower or (c) to our knowledge,
constitute a breach or a default under any material agreement or instrument to
which the Borrower is a party or by which it or its assets are bound or result
in the creation of a mortgage, security interest or other encumbrance upon the
assets of the Borrower except as and to the extent provided in the Financing
Documents.

 
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5. Subject to the limitations in the next section of this paragraph 5, the
Financing Documents are the valid and binding obligations of the Borrower
enforceable against the Borrower.

The validity, binding effect and enforceability of the Financing Documents might
be limited or otherwise affected by (a) bankruptcy, insolvency, reorganization,
moratorium, fraudulent conveyance or similar statutes, rules, regulations or
other laws affecting the enforcement of creditors' rights and remedies generally
and (b) the unavailability of, or limitation on the availability of, a
particular right or remedy (whether in a proceeding in equity or at law) because
of an equitable principle or a requirement as to commercial reasonableness,
conscionablity or good faith. In addition, certain remedies, waivers and
provisions of the Financing Documents might not be enforceable; nevertheless,
such unenforceability will not render the Financing Documents invalid as a
whole.

6. We note that the Financing Documents provide that they are governed by New
York law. It is our opinion that a Florida court of competent jurisdiction or a
federal court sitting in the state of Florida in an action to enforce or
interpret the Financing Documents, assuming the proper argument thereof, should
give effect to the choice of New York law as the governing law of the Financing
Documents and to the interpretation thereof, subject to applicable conflicts of
laws decisions and provided that application of New York law in any instance
would not result in the violation of the public policy of the State of Florida.

Certain of the opinions set forth herein are limited “to our knowledge.”
Whenever our opinion is so limited, we mean that, during the course of our
engagement for this opinion, no information has come to the attention of any of
our attorneys working on the engagement that would give them actual knowledge of
the existence or absence of such facts. We have not undertaken any independent
investigation to determine the existence or absence of such facts, and no
inference as to our knowledge of the existence or absence of such facts should
be drawn from our engagement.

7. Provided that all of the Financing Documents are both executed and delivered
outside of the territorial limits of the State of Florida, the Financing
Documents are not subject to Florida Documentary Stamp Tax or Florida
Intangibles Tax.
 
We are members of the Florida Bar and the opinions expressed herein are limited
to the federal law of the United States and the laws of the State of Florida. We
note that the Financing Documents are governed by the laws of the State of New
York, and with your permission the opinions rendered herein assume that the laws
of New York are the same as the laws of the State of Florida. Without limiting
the generality of the foregoing, we express no other opinion concerning the laws
of any other jurisdiction in which the Borrowers may be located, may transact
business, or in which enforcement of the Transaction Documents may be sought.

 
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Except as expressly set forth herein, no other opinion is made with respect to
the Borrower, the Lender, the Financing Documents or the transactions evidenced
thereby.

Other than the addressees and their respective assignees and transferees, no
person may rely on this opinion without our prior written consent. This opinion
is issued as of the date hereof and we undertake no, and hereby disclaim any,
obligation to advise you as to any change or modification to any state of facts
or law that would affect our opinions as stated herein.

 

 
Very truly yours,

 
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[sig_logo.jpg]
 
PROMISSORY NOTE
 
$1,000,000.00
October__ , 2008

 
On October__ , 2009 (the “Maturity Date”), for value received, Oragenics, Inc.
d/b/a ONI Biopharma Inc. having its principle office at 13700 Progress Blvd.,
Alachua, Florida, 32615 (the “Borrower”), promises to pay to the order of
SIGNATURE BANK, having an office at 565 Fifth Avenue, New York, NY 10017 (the
“Bank”), at such office of the Bank or at such other place as the holder hereof
may from time to time appoint in writing, in lawful money of the United States
of America in immediately available funds, the principal sum of ONE MILLION and
00/100 ($1,000,000.00) Dollars or such lesser amount as may then be the
aggregate unpaid principal balance of all loans made by the Bank to the Borrower
hereunder (each a “Loan” and collectively the “Loans”) as shown on the schedule
attached to and made a part of this Note. Within the $1,000,000.00 limit of this
Note, Loans may be obtained, repaid and re-borrowed on a revolving basis. The
Borrower also promises to pay interest (computed on the basis of a 360 day year
for actual days elapsed) at said office in like money on the unpaid principal
amount of each Loan from time to time outstanding at a rate per annum equal to
the Prime Rate. Interest on each Loan shall be payable monthly on the first day
of each month commencing the first such day to occur after a Loan is made
hereunder and, together with principal, on the maturity thereof. The Borrower
further agrees that upon and following an Event of Default and/or after any
stated or any accelerated maturity of Loans hereunder, all Loans shall bear
interest (computed daily) at a rate equal to 4% per annum in excess of the rate
then applicable to such Loans, payable on demand. Furthermore, if the entire
amount of any principal and/or interest required to be paid pursuant to this
Note is not paid in full within ten (10) days after the same is due, the
Borrower shall further pay to the Bank a late fee equal to Five percent (5%) of
the required payment. In no event shall interest payable hereunder be in excess
of the maximum rate of interest permitted under applicable law. If any payment
to be so made hereunder becomes due and payable on a day other than a Business
Day, such payment shall be extended to the next succeeding Business Day and, to
the extent permitted by applicable law, interest thereon shall be payable at the
then applicable rate during such extension.
 
All payments made in connection with this Note shall be in lawful money of the
United States in immediately available funds. All such payments shall be applied
first to the payment of all fees, expenses and other amounts due to the Bank
(excluding principal and interest), then to accrued interest, and the balance on
account of outstanding principal; provided, however, that after the occurrence
of an Event of Default, payments will be applied to the obligations of the
Borrower to the Bank as the Bank determines in its sole discretion. The Borrower
hereby expressly authorizes the Bank to record on the attached schedule the
amount and date of each Loan, the rate of interest thereon, Interest Period
thereof and the date and amount of each payment of principal. All such notations
shall be presumptive as to the correctness thereof; provided, however, the
failure of the Bank to make any such notation shall not limit or otherwise
affect the obligations of the Borrower under this Note.
 
 
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In consideration of the granting of the Loans evidenced by this Note, the
Borrower hereby agrees as follows:
 
1. Loan Requests. Requests for Loans may be made up until 1 p.m. on the date the
Loan is to be made. Any request for a Loan must be written. The Bank shall have
no obligation to make any Loan hereunder.
 
2. Prepayment. The Borrower may prepay any Loan at any time in whole or in part
without premium or penalty. Each such prepayment shall be made together with
interest accrued thereon to and including the date of prepayment.
 
3. Warranties and Representations.
 
oFor Individuals            þ For Institutions
  

The Borrower represents and warrants that: a) it is duly organized, validly
existing and in good standing under the laws of the state of its organization
and is qualified to do business and is in good standing under the laws of every
state where its failure to so qualify would have a material and adverse effect
on the business, operations, property or other condition of the Borrower; b) the
execution, issuance and delivery of this Note by the Borrower are within its
organizational powers and have been duly authorized, and the Note is valid,
binding and enforceable in accordance with its terms, and is not in violation of
law or of the terms of the Borrower's organizational documents and does not
result in the breach of or constitute a default under any indenture, agreement
or undertaking to which the Borrower is a party or by which it or its property
may be bound or affected; c) no authorization or approval or other action by,
and no notice to or filing with, any governmental authority or regulatory body
is required for the due execution, delivery and performance by the Borrower of
this Note, except those as have been obtained; d) the financial statements of
the Borrower heretofore furnished to the Bank are complete and correct and
fairly represent the financial condition of the Borrower and its subsidiaries as
at the dates thereof and for the periods covered thereby, which financial
condition has not materially, adversely, changed since the date of the most
recently dated balance sheet heretofore furnished to the Bank; e) no Event of
Default (as hereinafter defined) has occurred and no event has occurred which
with the giving of notice or the lapse of time or both would constitute an Event
of Default; f) the Borrower shall not use any part of the proceeds of any Loan
to purchase or carry any margin stock within the meaning of Regulation U of the
Board of Governors of the Federal Reserve System or to extend credit to others
for the purpose of purchasing or carrying any margin stock; g) there is no
pending or, to the knowledge of the Borrower, threatened action or proceeding
affecting the Borrower before any court, governmental agency or arbitrator
which, if determined adversely to the Borrower would have a materially adverse
effect on the financial condition or operations of the Borrower except as
described in the financial statements of the Borrower heretofore furnished to
the Bank; and h) on the occasion of the granting of each Loan all
representations and warranties contained herein shall be true and correct and
with the same force and effect as though such representations and warranties had
been made on and as of the date of the making of each such Loan.  
 
 
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4. Events of Default. Upon the occurrence of any of the following specified
events of default (each an “Event of Default”): a) default in making any payment
of principal, interest, or any other sum payable under this Note when due; or b)
default by the Borrower (i) of any other obligation hereunder or (ii) in the due
payment of any other obligation owing to the Bank or (iii) under any other
document, instrument and/or agreement with or in favor of the Bank; or c)
default by Borrower in the due payment of any other indebtedness for borrowed
money or default in the observance or performance of any covenant or condition
contained in any agreement or instrument evidencing, securing, or relating to
any such indebtedness, which causes or permits the acceleration of the maturity
thereof; or d) any representation or warranty made by the Borrower herein or in
any certificate furnished by the Borrower in connection with the Loans evidenced
hereby or pursuant to the provisions hereof, proves untrue in any material
respect; or e) the Borrower becomes insolvent or bankrupt, is generally not
paying its debts as they become due, or makes an assignment for the benefit of
creditors, or a trustee or receiver is appointed for the Borrower or for the
greater part of the properties of the Borrower with the consent of the Borrower,
or if appointed without the consent of the Borrower, such trustee or receiver is
not discharged within 90 days, or bankruptcy, reorganization, liquidation or
similar proceedings are instituted by or against the Borrower under the laws of
any jurisdiction, and if instituted against the Borrower are consented to by it
or remain undismissed for 90 days, or a writ or warrant of attachment or similar
process shall be issued against a substantial part of the property of the
Borrower and shall not be released or bonded within 90 days after levy; or f)
the Bank shall have determined, in its sole discretion, that one or more
conditions exist or events have occurred which have resulted or may result in a
material adverse change in the business, properties or financial condition of
the Borrower as determined in the sole discretion of the Bank or one or more
other conditions exist or events have occurred with respect to the Borrower
which the Bank deems materially adverse; then, in any such event, and at any
time thereafter, if any Event of Default shall then be continuing, the Bank may
declare the principal and the accrued interest in respect of all Loans under
this Note to be, whereupon the Note shall become, immediately due and payable
without presentment, demand, protest or other notice of any kind, all of which
are expressly waived by the Borrower.
 
 
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5. Collateral Security. As collateral security for the payment of this Note and
of all other notes and/or obligations or Liabilities (as hereinafter defined) of
the Borrower, now of hereafter owned or held by the Bank, the Borrower grants
the Bank a security interest in, pledges and assigns to the Bank all monies
and/or other property now or hereafter held by the Bank (and/or any entity
controlling, controlled by or under common control with the Bank, each such
entity referred to herein as an “Affiliate”) on deposit, in safekeeping, or
otherwise, for the account of or to the credit of or belonging to the Borrower
or in which the Borrower shall have any interest, all of which is hereinafter
termed the collateral security. At any time, without demand or notice, the Bank
may set off all deposits, credits, collateral and property, now or hereafter in
the possession, custody, safekeeping or control of the Bank or any Affiliate, or
in transit to any of them, or any part thereof and apply the same to any of the
Liabilities even though unmatured and regardless of the adequacy of any other
collateral securing the Liabilities. ANY AND ALL RIGHTS TO REQUIRE THE BANK TO
EXERCISE ITS RIGHTS OR REMEDIES WITH RESPECT TO ANY OTHER COLLATERAL WHICH
SECURES THE LIABILITIES, PRIOR TO EXERCISING ITS RIGHT OF SETOFF WITH RESPECT TO
SUCH DEPOSITS, CREDITS OR OTHER PROPERTY OF THE BORROWER OR OTHER PARTY
OBLIGATED ON THIS NOTE, ARE HEREBY KNOWINGLY, VOLUNTARILY AND IRREVOCABLY
WAIVED. The Bank at any time, before or after an Event or Default (as herein
defined), may but shall not be obligated to, transfer into or out of its own
name or that of its nominee all or any of the collateral security, including
stocks, bonds, and other securities, and the Bank or its nominee may demand, sue
for, collect, receive and hold as like collateral security any or all interest,
dividends and income thereon and if the securities are held in the name of the
Bank or its nominee, the Bank may, after an Event of Default, exercise all
voting and other rights pertaining thereto as if the Bank were the absolute
owner thereof; but the Bank shall not be obligated to demand payment of,
protest, or take any steps necessary to preserve any rights in the collateral
against prior parties, or to take any action whatsoever in regard to the
collateral security or any part thereof, all of which the Borrower assumes and
agrees to do. Without limiting the generality of the foregoing, the Bank shall
not be obligated to take any action in connection with any conversion, call,
redemption, retirement or any other event relating to any of the collateral
security, unless the Borrower gives written notice to the Bank that such action
shall be taken not more than thirty (30) days prior to the time such action may
first be taken and not less than ten (10) days prior to the expiration of the
time during which such action may be taken. The term “Liabilities” shall include
this Note and all other indebtedness and obligations and liabilities of any kind
of the Borrower to the Bank, now or hereafter existing, arising directly between
the Borrower and the Bank or acquired by assignment, conditionally or as
collateral security by the Bank, absolute or contingent, joint and/or several,
secure or unsecured, due or not due, contractual or tortious, liquidated or
unliquidated, arising by operation of law or otherwise, direct or indirect,
including, but without limiting the generality of the foregoing, indebtedness,
obligations or liabilities to the Bank of the Borrower as a member of any
partnership, syndicate, association or other group, and whether incurred by the
Borrower as principal, surety, endorser, guarantor, accommodation party or
otherwise. This Note and all of the aforementioned obligations and Liabilities
are also secured by (a) any and all property of the Borrower and/or any
Guarantor and/or any other party obligated on this Note, now or hereafter
subject to a security agreement, mortgage, pledge agreement, assignment,
hypothecation or other document granting the Bank or an Affiliate a security
interest or other lien or encumbrance and (b) any and all collateral described
in any and all credit accommodations, notes, loan agreements, and any other
agreements and documents, now or hereafter existing, creating, evidencing,
guaranteeing, securing or relating to any or all of the Liabilities, together
with all amendments, modifications, renewals, or extensions thereof. In
addition, Borrower has pledged to Bank as security for the Loan money market
account number _______________ maintained with Bank as set forth in a Pledge
Agreement of even date herewith between Borrower and Bank.
 
6. Definitions. As used herein:
 
(a) “Business Day” means a day other than a Saturday, Sunday or other day on
which commercial banks in New York are required or permitted by law to remain
closed.
 
(b) ““Loan Documents” means each document, instrument or agreement executed
pursuant hereto or in connection herewith, together with each other document,
instrument or agreement made with or in favor of the Bank.
 
(c) “Prime Rate” means the variable per annum rate of interest so designated
from time to time by the Bank as its prime rate. The Prime Rate is a reference
rate and does not necessarily represent the lowest or best rate being charged to
any customer.
 
 
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7. Miscellaneous.
 
(a) The Borrower agrees to pay on demand all of the Bank's costs and expenses,
including reasonable counsel fees, in connection with collection of any sums due
to the Bank and enforcement of its rights under this Note.
 
(b) No modification or waiver of any provision of this Note shall be effective
unless such modification or waiver shall be in writing and signed by a duly
authorized officer of the Bank, and the same shall then be effective only for
the period and on the conditions and for the specific instances specified in
such writing. No failure or delay by the Bank in exercising any right, power or
privilege hereunder shall operate as a waiver thereof; nor shall any single or
partial exercise thereof preclude any other or further exercise thereof or the
exercise of any rights, power or privilege.
 
(c) The Borrower hereby waives presentment, demand for payment, notice of
protest, notice of dishonor, and any and all other notices or demands except as
otherwise expressly provided for herein.
 
(d) This Note shall be construed in accordance with and governed by the laws of
the State of New York (excluding the laws applicable to conflicts or choice of
law). The Borrower agrees that any suit for the enforcement of this Note or any
of the other Loan Documents may be brought in the courts of the State of New
York or any Federal court sitting therein and consents to the nonexclusive
jurisdiction of such court and service of process in any such suit being made
upon the Borrower by mail at the address set forth in the first paragraph of
this Note. The Borrower hereby waives any objection that it may now or hereafter
have to the venue of any such suit or any such court or that such suit is
brought in an inconvenient forum.
 
(e) The Bank may at any time pledge all or any portion of its rights under this
Note and the loan documents executed in connection therewith (the “Loan
Documents”) to any of the twelve (12) Federal Reserve Banks organized under
Section 4 of the Federal Reserve Act, 12 U.S.C. Section 341. No such pledge or
enforcement thereof shall release the Bank from its obligations under any of
such loan documents.
 
(f) EACH PARTY HERETO HEREBY WAIVES, TO THE FULLEST EXTENT PERMITTED BY
APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN ANY LEGAL PROCEEDING
DIRECTLY OR INDIRECTLY ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE
TRANSACTIONS CONTEMPLATED HEREBY (WHETHER BASED ON CONTRACT, TORT OR ANY OTHER
THEORY). EACH PARTY HERETO (A) CERTIFIES THAT NO REPRESENTATIVE, AGENT OR
ATTORNEY OF ANY OTHER PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH
OTHER PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING
WAIVER AND (B) ACKNOWLEDGES THAT IT AND THE OTHER PARTIES HERETO HAVE BEEN
INDUCED TO ENTER INTO THIS AGREEMENT BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS
AND CERTIFICATIONS IN THIS SECTION 7(f).
 
(g) The Bank shall have the unrestricted right at any time and from time to
time, and without the consent of or notice to the Borrower or any other party
obligated on this Note, to grant to one or more banks or other financial
institutions (each, a “Participant”) participating interests in the Bank’s
obligation to lend hereunder and/or any or all of the Loans held by the Bank
hereunder. In the event of any such grant by the Bank of a participating
interest to a Participant, whether or not upon notice to the Borrower, the Bank
shall remain responsible for the performance of its obligations hereunder and
the Borrower shall continue to deal solely and directly with the Bank in
connection with the Bank’s rights and obligations hereunder. The Bank may
furnish any information concerning the Borrower in its possession from time to
time to prospective assignees and Participants, provided that the Bank shall
require any such prospective assignee or Participant to agree in writing to
maintain the confidentiality of such information.
 
 
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(h) This Note shall be binding upon and inure to the benefit of the Borrower,
the Bank, all future holders of this Note and their respective successors and
assigns, except that the Borrower may not assign or transfer any of its rights
under this Note without the prior written consent of the Bank. The term “Bank”
as used herein shall be deemed to include the Bank and its successors, endorsees
and assigns. The Bank shall have the unrestricted right at any time or from time
to time, and without the Borrower’s consent, to assign all or any portion of its
rights and obligations hereunder to one or more banks or other financial
institutions (each, an “Assignee”), and the Borrower agrees that it shall
execute, or cause to be executed, such documents, including without limitation,
amendments to this Note and to any other documents, instruments and agreements
executed in connection herewith as the Bank shall deem necessary to effect the
foregoing. In addition, at the request of the Bank and any such Assignee, the
Borrower shall issue one or more new promissory notes, as applicable, to any
such Assignee and, if the Bank has retained any of its rights and obligations
hereunder following such assignment, to the Bank, which new promissory notes
shall be issued in replacement of, but not in discharge of, the liability
evidenced by the promissory note held by the Bank prior to such assignment and
shall reflect the amount of Loans held by such Assignee and the Bank after
giving effect to such assignment. Upon the execution and delivery of appropriate
assignment documentation, amendments and any other documentation required by the
Bank in connection with such assignment, and the payment by Assignee of the
purchase price agreed to by the Bank, and such Assignee, such Assignee shall be
a party to this Agreement and shall have all of the rights and obligations of
the Bank hereunder (and under any and all other guaranties, documents,
instruments and agreements executed in connection herewith) to the extent that
such rights and obligations have been assigned by the Bank pursuant to the
assignment documentation between the Bank and such Assignee, and the Bank shall
be released from its obligations hereunder and thereunder to a corresponding
extent.
 
(i) This Note and the other Loan Documents are intended by the parties as the
final, complete and exclusive statement of the transactions evidenced thereby.
All prior or contemporaneous promises, agreements and understandings, whether
oral or written, are deemed to be superceded by this Note and such other Loan
Documents, and no party is relying on any promise, agreement or understanding
not set forth in this Note or such other Loan Documents. Neither this Note nor
any of such other Loan Documents may be amended or modified except by a written
instrument describing such amendment or modification executed by the Borrower
and the Bank.
 
(j) Each party hereto acknowledges that this Note was made, executed and
delivered outside the State of Florida, and no Florida documentary stamp tax is
due hereon. The Borrower agrees to indemnify the Bank for the amount of any such
documentary stamp tax, together with other reasonable costs and expenses, which
may arise in the event such documentary stamp tax is deemed to apply to this
Note.
 
 
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Oragenics, Inc. d/b/a ONI Biopharma Inc.
 

 
By: /s/ David B.Hirsch                                   
Name: David Hirsch
Title: COO-CFO

 
 
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LOAN AND REPAYMENT SCHEDULE
PROMISSORY NOTE DATED OCTOBER__, 2008
ORAGENICS, INC. to SIGNATURE BANK

         
Date
Amount of Loan
Amount of Principal Repayment
Unpaid Principal Balance
Notation
Made By
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
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[sig_logo.jpg]

PLEDGE AGREEMENT

Oragenics, Inc., d/b/a Oni Biopharma Inc., located at 13700 Progress Blvd.,
Alachua, Florida, 32615 (hereinafter jointly and severally if more than one,
referred to herein as the "Pledgor"), and Signature Bank, having an office
located at 565 Fifth Avenue, 12th Floor, New York, New York 10017, (hereinafter
referred to herein as the "Bank"), hereby agree as follows:

1.Definitions. The following definitions apply:

Borrower: shall mean Oragenics, Inc (hereinafter jointly and severally if more
than one, referred to herein as "Borrower").

Liabilities: All obligations, indebtedness and liability of any type whatsoever
of the Borrower and the Pledgor to the Bank, which arise out of or in connection
with or which in any way relates to that certain Line of Credit from the
Borrower to the Bank in the original principal amount of: ($1,000,000.00) One
Million Dollars, (hereinafter referred to herein as the "Loan") executed in
connection herewith, whether now existing or hereafter incurred, whether direct,
indirect, absolute or contingent, whether otherwise guaranteed or secured, and
howsoever evidenced or acquired, and expenses or costs incurred by the Bank in
the administration of this Pledge Agreement and the enforcement of any of its
rights with respect thereto.

For and in consideration of the sum of TEN ($10.00) DOLLARS, and for other good
and valuable consideration, the receipt and sufficiency of which is hereby
acknowledged, and for and in consideration of inducing the Bank to lend to the
Borrower the principal sum referred to hereinabove, the Pledgor hereby pledges
to the Bank as collateral security for said loan, the following pledged
collateral:

Pledged Collateral: (i) The property delivered or otherwise transferred by the
Pledgor to the Bank and consisting, as of the date of this Agreement, of the
property described on affixed Exhibit A attached hereto and made a part hereof;
and/or any and all substitutions, additions and accessions thereto upon which
the Pledgor hereby grants and pledges to the Bank and upon which the Bank shall
have absolute control over the pledged collateral which shall include, but not
be limited to, investment property, securities, security entitlements and any
and all financial assets credited to said pledged collateral; (ii) any and all
securities (both certificated and uncertificated), closely held capital stock,
notes, mortgages, instruments, documents, letters of credit, certificates of
deposit, deposit accounts, bank accounts, balances in any account of the Pledgor
with the Bank, and all other property interests which may subsequently be
delivered or transferred by the Pledgor to the Bank; (iii) any of the foregoing
when put in transit to the Bank; (iv) in the case of securities and closely held
capital stock, Pledged Collateral shall include, without limitation, all shares
of any class of the capital stock of the issuer which shall be issued or
distributed (by way of stock dividends or otherwise) or sold by the issuer to
the Pledgor at any time or times after the date of this Agreement or which shall
be purchased or otherwise acquired by or on behalf of the Pledgor from the
issuer or from any other person or persons at any time or times after the date
of this Agreement; all dividends of every kind which shall become and be due and
payable or distributable on or in respect of all or any of the securities and
closely held capital stock; all payments of every kind whatever which shall
become and be due and payable or distributable on account of the purchase,
redemption, repurchase or other retirement of all or any of the securities and
closely held capital stock; all other distributions of every kind (including,
without limitation, all capital distributions) which shall become and be due and
payable or distributable on or in respect of the securities and closely held
capital stock; and (v) all proceeds of the foregoing, including, without
limitation, the roll-over or reinvested proceeds of the foregoing. Any delivery
or transfer of any of the Pledged Collateral to an agent or custodian designated
by the Bank shall be deemed a delivery or transfer to the Bank.

2. Security Interest. The Pledgor hereby pledges, hypothecates, and impresses
the Pledged Collateral with a lien in favor of the Bank, and grants to the Bank
a security interest in the Pledged Collateral, to secure the punctual payment
and performance of all the Liabilities.

3. Pledgor's Additional Obligations. The Pledgor agrees that: (1) any
distribution in kind received by the Pledgor from any party for or on account of
the Pledged Collateral, including distributions of stock as a dividend or split
of any of the Pledged Collateral, shall be immediately delivered to the Bank in
the form received with any required endorsement; (2) additional collateral in
form and kind satisfactory to the Bank will be deposited by the Pledgor with the
Bank if the Bank at any time deems the Pledged Collateral insufficient or
unsatisfactory; (3) any note or other instrument executed and delivered to the
Pledgor by any party to evidence any obligation of such party with respect to
the Pledged Collateral shall be immediately delivered with any required
endorsement to the Bank. All such items shall be held by the Bank in accordance
with the terms of this Pledge Agreement.

The Pledgor agrees to pay to the Bank on demand all reasonable fees, costs and
expenses incurred by the Bank in connection with the administration of this
Pledge Agreement, including, without limitation, overnight courier fees, lien
search fees, and filing and recording fees.

The Pledgor agrees to execute and deliver to the Bank and/or third parties
designated by the Bank such additional documents, notices, requests and other
instruments as the Bank deems necessary or advisable to protect the Bank's
rights under this Pledge Agreement.
 
 
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4. Certain Rights and Duties of Bank. The Pledgor acknowledges that: the Bank
has no duty of any type with respect to the Pledged Collateral except for the
use of due care in safekeeping any of the Pledged Collateral actually in the
physical custody of the Bank; prior to the occurrence of any event of default
described in the succeeding paragraph the Bank's rights with respect to the
Pledged Collateral shall be limited to the Bank's rights as a secured party and
pledgee and the right to perfect its security interest, preserve, enforce and
protect the lien granted hereunder and its interest in the Pledged Collateral;
and the Bank may sell, assign or grant participations in any of the Liabilities
and any of the Pledged Collateral and that the Bank's purchaser, assignee or
participant shall have the same rights and privileges with respect to such
Liabilities and Pledged Collateral as the Pledgor grants to the Bank under this
Pledge Agreement. With respect to any Pledged Collateral with a stated maturity
date (including, without limitation, certificates of deposit and other term
accounts), the Bank is authorized and directed, upon maturity, to roll-over and
reinvest such Pledged Collateral in a similar investment, with such tenor and
interest rate or yield as the Bank, in its discretion, deems to be reflective of
prevailing market conditions. Prior to the occurrence of any event of default
described in the succeeding paragraph, the Bank agrees that it will not vote any
Pledged Collateral constituting securities or closely held capital stock.

5. Events of Default; Remedies. Upon occurrence of any event of default under
any instrument evidencing any of the Liabilities or of any of the following
events: (1) default in the payment or performance of any other of the
obligations or liabilities of the Pledgor under any agreement between the Bank
and Pledgor; (2) the Pledgor, if a business entity, discontinues business
operations at any of the Pledgor's locations; (3) the Pledgor is generally
unable to pay debts as they become due or the Bank deems itself insecure; (4)
the Pledgor makes a general assignment for the benefit of creditors; (5) the
entry of a decree, order or order for relief by a court having jurisdiction of a
case initiated by or against the Pledgor under the federal bankruptcy code or
any other federal or state laws pursuant to which a receiver, liquidator,
assignee, custodian, trustee, sequestrator, debtor in possession, examiner or
other similar official, is appointed for the Pledgor or any of the Pledgor's
property, with or without consent, for any purpose whatsoever; (6) a substantial
part of the property of the Pledgor is taken by attachment, execution or any
other form of legal process; (7) the assertion of any levy, seizure or
attachment on the Pledged Collateral; or (8) death of an individual Pledgor or
dissolution or termination of legal existence of a corporate, limited liability
company, partnership or trust Pledgor; then the Bank, with or without notice to
the Pledgor and without demand for additional collateral, may (a) transfer the
Pledged Collateral into the name of the Bank or its nominee and vote any Pledged
Collateral constituting securities or closely held capital stock; (b) sell at
public or private sale any or all of the Pledged Collateral, which the Bank may
purchase free from any right of redemption; or (c) at its discretion in its own
name or in the name of the Pledgor take any action for the collection of the
Pledged Collateral, including the filing of a proof of claim in insolvency
proceedings, and may receive the proceeds thereof and execute releases therefor.
After deducting its expenses, including reasonable attorney's fees (which may
include costs allocated by the Bank's internal legal department), incurred in
the sale or collection of the Pledged Collateral, the Bank shall apply the
proceeds to the Liabilities and shall account to the Pledgor for any surplus.
The Pledgor agrees that the Bank has no obligation to sell or otherwise
liquidate the Pledged Collateral in any particular order or to apply the
proceeds thereof to any particular portion of the Liabilities. The Pledgor
further agrees that after the occurrence of an event of default, the Bank shall
have no obligation to vote any Pledged Collateral constituting securities or
closely held capital stock.

In connection with any secured party's sale, the Bank is authorized, if it deems
it advisable to do so, in order to comply with any applicable securities laws,
to restrict the prospective bidders or purchasers to persons who will represent
and agree that they are purchasing the Pledged Collateral for their own account
for investment, and not with a view to the distribution or re-sale thereof.
Sales made subject to such restriction shall be deemed to have been made in a
commercially reasonable manner.

6. Power of Attorney, Etc. The Pledgor hereby irrevocably constitutes and
appoints the Bank the true and lawful attorney-in-fact for and on behalf of the
Pledgor with full power of substitution and revocation in its own name or in the
name of the Pledgor to make, execute, deliver and record any and all financing
statements, continuation statements, assignments, proofs of claim, powers of
attorney, leases, discharges or other instruments or agreements which the Bank
in its sole discretion may deem necessary or advisable to perfect, preserve,
enforce or protect the lien granted hereunder and its interest in the Pledged
Collateral and to carry out the purposes of this Pledge Agreement, including but
without limiting the generality of the foregoing, any and all proofs of claim in
bankruptcy or other insolvency proceedings of the Borrower, with the right to
collect and apply to the Liabilities all distributions and dividends made on
account of the Pledged Collateral. The rights and powers conferred on the Bank
by the Pledgor are expressly declared to be coupled with an interest and shall
be irrevocable until all the Liabilities are paid and performed in full. A
carbon, photographic, or other reproduction of a security agreement (including
this Pledge Agreement) or a financing statement is sufficient as a financing
statement.

7. Miscellaneous. This Pledge Agreement and the Pledged Collateral shall not be
in any way affected by the extension of time or renewal of any of the
Liabilities, the modification in any manner or the taking or release in whole or
in part of any security therefor or the obligations of any endorsers, sureties,
guarantors or other parties or the granting of any other indulgences to the
Borrower or to the Pledgor. No termination of this Pledge Agreement shall be
effective in any event until the Bank in its discretion determines that the
Liabilities of the Borrower covered by this Pledge Agreement have been satisfied
in full.
 

8. Notices. Except as otherwise specifically provided for herein, any notice,
demand or communication hereunder shall be given in writing (including facsimile
transmission or telex) and mailed or delivered to each party at its address set
forth below, or, as to each party, at such other address as shall be designated
by such party by a prior notice to the other party in accordance with the terms
of this provision.

 
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Any notice to the Bank shall be sent as follows:

Signature Bank
565 Fifth Avenue
New York, NY, 10017
Attention: Vincent P. Vindigni
Any notice to the Pledgor shall be sent as follows:

Oragenics, Inc.
13700 Progress Blvd.
Alachua, Florida, 32615
Attention: Stanley B. Stein, President

All notices hereunder shall be effective (i) five (5) business days after such
notice is mailed, by registered or certified mail, postage prepaid (return
receipt requested), (ii) upon delivery by hand, (iii) upon delivery if delivered
by overnight courier (such delivery to be evidenced by the courier's records),
and (iv) in the case of any notice or communication by telex or telecopy, on the
date when sent.

9. Joint and Several Obligations; Construction. If more than one Pledgor has
signed this Pledge Agreement, the obligations of the Pledgor are joint and
several. The term "Pledgor" and all pronouns referring thereto as used herein
shall be construed in the masculine, feminine, neuter or singular or plural as
the context may require.

10. Successors and Assigns. This Pledge Agreement shall inure to the benefit of
the Bank and its successors and assigns and shall bind the Pledgor and the
successors, representatives, legal representatives and/or heirs and assigns of
the Pledgor.

This Pledge Agreement has been executed by the Pledgor and the Bank as of the
day and date written hereinbelow.

PLEDGOR:

Oragenics, Inc. d/b/a ONI Biopharma Inc.

/s/ David Hirsch                        
By: David Hirsch, CFO-COO

DATE: 10/20/2008                  

EXECUTED IN THE PRESENCE OF:

________________________________
WITNESS AS TO PLEDGOR

BANK:

SIGNATURE BANK

By: /s/ Joseph Festa                                      
Title: ___________________________

Date: 10/20/2008                                          

EXECUTED IN THE PRESENCE OF:

________________________________
WITNESS AS TO BANK

SEE EXHIBIT "A" ATTACHED HERETO, MADE A PART HEREOF AND INCORPORATED HEREIN BY
REFERENCE.
 
 
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EXHIBIT A

(Description of Pledged Collateral)

   
I. Securities and Closely Held Capital Stock (Corporate)
       
Issuer
No. of Shares
Certificate No.
Cusip No.
               

 

 
II. Securities (U. S. Government & Federal Agency Securities)
   
Par
 
Issue
Interest
Maturity
Description
Value
Cusip No.
Date
Rate
Date
           

 

 
III. Certificates of Deposit
 
Issuer
Par Value
Interest Rate
Maturity Date
           
IV. OTHER*
 
THAT CERTAIN COLLATERAL IN ITS ENTIRETY HELD IN A Fidelity Prime Fund Account AT
SIGNATURE BANK (NUMBER: # _______________) IN THE SOLE NAME OF THE PLEDGOR.
 

 

*OR ANY AND ALL SUBSTITUTIONS AND/OR ADDITIONS ACCEPTABLE TO THE BANK IN THE
BANK’S SOLE AND ABSOLUTE DISCRETION

THE COLLATERAL PLEDGED HEREIN SHALL REMAIN IN THE BANK’S POSSESSION AT ALL
TIMES.

Pledgor's Initials: 

___________

Date: ________________

 
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