Exhibit 10.1

SECURITIES PURCHASE AGREEMENT

This Securities Purchase Agreement, dated on and as of the latest date set forth
on the signature page hereto (this “Agreement”), is made between Cardium
Therapeutics, Inc., a Delaware corporation (the “Company”), the undersigned
purchaser(s) (each a “Purchaser” and collectively, the “Purchasers”) and each
assignee of a Purchaser who becomes a party hereto.

WHEREAS, subject to the terms and conditions set forth in this Agreement and
pursuant to Section 4(2) of the Securities Act of 1933, as amended (the
“Securities Act”) and Rule 506 of Regulation D promulgated thereunder, the
Company desires to offer, issue and sell to the Purchasers (the “Offering”), and
the Purchasers, severally and not jointly, desire to purchase from the Company,
shares (the “Shares”) of the Company’s common stock, par value $0.0001 per share
(the “Common Stock”), and five-year warrants to purchase shares of Common Stock
(the “Warrants”), with an exercise price per share equal to $3.75. The Shares
and the Warrants are collectively referred to herein as the “Securities”.

NOW, THEREFORE, in consideration of the mutual covenants and agreements
contained in this Agreement, and for other good and valuable consideration the
receipt and adequacy of which is hereby acknowledged, the Company and each of
the Purchasers agree as follows:

 

A. Subscription

(1) Subject to the conditions to closing set forth herein, each Purchaser hereby
irrevocably subscribes for and agrees to purchase Securities for the aggregate
purchase price set forth on the signature page of such Purchaser hereto (the
“Subscription Amount”). The Securities to be issued to a Purchaser hereunder
shall consist of (i) Shares in an amount equal to the quotient of (x) the
Subscription Amount, divided by (y) the Offering Price, rounded down to the
nearest whole number, and (ii) a Warrant to purchase such number of shares of
Common Stock to be determined based on a ratio of one (1) share of Common Stock
for every 2.85714 Shares purchased hereunder, rounded down to the nearest whole
number. The aggregate amount of Securities to be issued pursuant to the Offering
shall not exceed 8,636,000 Shares and Warrants to purchase 3,022,600 shares of
Common Stock. The Company shall allocate the Subscription Amount between the
Shares and the Warrants prior to the Closing (as defined below) and provide
notice to the Purchasers of such allocation.

(2) For purposes of this Agreement, the “Offering Price” shall be $2.50, which
shall be the price per Share to be paid by the Purchasers.

(3) The Company shall use its commercially reasonable efforts to hold the
closing of the Offering (the “Closing”, and the date of the Closing, the
“Closing Date”) within three (3) business days after the date of this Agreement.
Prior to the Closing, each Purchaser shall deliver the applicable Subscription
Amount, by wire transfer to such escrow account in accordance with the wire
transfer instructions set forth on Schedule A, and such amount shall be held in
the manner described in Paragraph (4) below. There is no minimum subscription
amount required for the Closing.

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(4) All payments for Securities made by the Purchasers will be deposited as soon
as practicable for the undersigned’s benefit in a non-interest bearing escrow
account. Payments for Securities made by the Purchasers will be returned
promptly, prior to an applicable Closing, without interest or deduction, if, or
to the extent, (i) the undersigned’s subscription is rejected; (ii) the Offering
is terminated for any reason; or (iii) upon request by the Purchaser, the
Closing does not occur within five (5) business days after the date of this
Agreement; provided, however, that the foregoing clause (iii) shall not relieve
any Purchaser of any liability in the event the Closing does not occur within
such five (5) business day period due to the failure of a Purchaser to deliver
such Purchaser’s applicable Subscription Amount.

(5) Upon receipt by the Company of the requisite payment for all Securities to
be purchased by the Purchasers whose subscriptions are accepted, the Company
shall, at the Closing: (i) issue to each Purchaser stock certificates
representing the shares of Common Stock purchased at such Closing under this
Agreement; (ii) issue to each Purchaser a Warrant to purchase such number of
shares of Common Stock calculated based on the number of shares of Common Stock
issued at such Closing and in accordance with Paragraph (1) above; (iii) deliver
to the Purchasers and to Oppenheimer & Co. Inc., the placement agent for the
Offering (the “Placement Agent”), a certificate stating that the representations
and warranties made by the Company in Section C of this Agreement were true and
correct in all material respects when made and are true and correct in all
material respects on the date of each such Closing relating to the Securities
subscribed for pursuant to this Agreement as though made on and as of such
Closing date (provided, however, that representations and warranties that speak
as of a specific date shall continue to be true and correct as of the Closing
with respect to such date); (iv) cause to be delivered to the Placement Agent
and the Purchasers an opinion of Fisher Thurber LLP substantially in the form of
Exhibit A hereto and reasonably acceptable to counsel for the Placement Agent;
and (v) cause to be delivered to the Placement Agent and the Purchasers as of a
date within five (5) days of the Closing Date evidence of the good standing and
corporate existence of the Company and each of its subsidiaries issued in each
case by the Delaware Secretary of State. Notwithstanding anything to the
contrary herein, the Company and Purchasers agree that no funds may be released
to the Company from the escrow account until all of the items required to be
delivered by the Company pursuant to this Paragraph (5) have been delivered in
accordance with this Paragraph (5) and all other conditions to Closing set forth
in this Agreement have been satisfied or waived. Upon satisfaction or waiver of
all conditions to Closing set forth in this Agreement, funds may be released
from the escrow account upon mutual written instructions of the Company and the
Placement Agent.

(6) Each Purchaser acknowledges and agrees that (i) the purchase of Shares and
Warrants by such Purchaser pursuant to the Offering is subject to all the terms
and conditions set forth in this Agreement; and (ii) this Agreement shall be
binding upon such Purchaser upon the execution and delivery to the Company, in
care of the Placement Agent, of such Purchaser’s signed counterpart signature
page to this Agreement unless and until the Company shall reject the
subscription being made hereby by such Purchaser. In the event the Company
wishes to reduce a Purchaser’s subscription with respect to the number of Shares
and Warrants to be purchased, such reduction shall constitute a rejection of the
Purchaser’s subscription requiring the Purchaser to resubmit a signed
counterpart signature page of this Agreement reflecting the lower Subscription
Amount in the event such Purchaser still wishes to participate in the Offering.
The part of the original Subscription Amount attributable to the reduction shall
be promptly returned, without interest or deduction.

 

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B. Representations and Warranties of the Purchaser

Each Purchaser, severally and not jointly, hereby represents and warrants to the
Company and the Placement Agent, and agrees with the Company as follows:

(1) The Purchaser has carefully read the Confidential Private Placement
Memorandum dated December 29, 2006, as amended by Supplement No. 1 to
Confidential Private Placement Memorandum dated February 13, 2007 (collectively,
the “PPM”) and related exhibits, this Agreement and the form of Warrant attached
hereto as Exhibit B (collectively the “Offering Documents”), and is familiar
with and understands the terms of the Offering. Specifically, and without
limiting in any way the foregoing representation, the Purchaser has carefully
read and considered the Company’s (a) Annual Report on Form 10-KSB for the
fiscal year ended December 31, 2005 (the “2005 Form 10-KSB”), including, without
limitation, the financial statements included therein and the sections therein
entitled “Item 1. Description of Business,” Item 6. “Management’s Discussion and
Analysis or Plan of Operation,” and “Risks” (which is contained in Item 6), and
(b) Quarterly Report on Form 10-QSB for the quarter ended September 30, 2006,
including, without limitation, the subsections of such Form 10-QSB entitled
“Item 1. Financial Statements,” and “Item 2. Management’s Discussion and
Analysis or Plan of Operation” and (c) Proxy Statement dated January 17, 2006.
The Purchaser has relied only on the information contained in the Offering
Materials and has not relied on any representation made by any other person. The
Purchaser fully understands all of the risks related to the purchase of the
Securities. The Purchaser has carefully considered and has discussed with the
Purchaser’s professional legal, tax, accounting and financial advisors, to the
extent the Purchaser has deemed necessary, the suitability of an investment in
the Securities for the Purchaser’s particular tax and financial situation and
has determined that the Securities being subscribed for by the Purchaser are a
suitable investment for the Purchaser. The Purchaser recognizes that an
investment in the Securities involves substantial risks, including the possible
loss of the entire amount of such investment. The Purchaser further recognizes
that the Company has broad discretion concerning the use and application of the
proceeds from the Offering.

(2) The Purchaser acknowledges that (i) the Purchaser has had the opportunity to
request copies of any documents, records, and books pertaining to this
investment and (ii) any such documents, records and books that the Purchaser
requested have been made available for inspection by the Purchaser, the
Purchaser’s attorney, accountant or advisor(s).

(3) The Purchaser and the Purchaser’s advisor(s) have had a reasonable
opportunity to ask questions of and receive answers from representatives of the
Company or persons acting on behalf of the Company concerning the Offering and
all such questions have been answered to the full satisfaction of the Purchaser.

(4) The Purchaser is not subscribing for Securities as a result of or subsequent
to any advertisement, article, notice or other communication published in any
newspaper, magazine or similar media or broadcast over television or radio or
presented at any seminar, meeting or conference whose attendees have been
invited by any general solicitation or general advertising.

 

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(5) If the Purchaser is a natural person, the Purchaser has reached the age of
majority in the state in which the Purchaser resides. Each Purchaser has
adequate means of providing for the Purchaser’s current financial needs and
contingencies, is able to bear the substantial economic risks of an investment
in the Securities for an indefinite period of time, has no need for liquidity in
such investment and can afford a complete loss of such investment.

(6) The Purchaser has sufficient knowledge and experience in financial, tax and
business matters to enable the Purchaser to utilize the information made
available to the Purchaser in connection with the Offering, to evaluate the
merits and risks of an investment in the Securities and to make an informed
investment decision with respect to an investment in the Securities on the terms
described in the Offering Documents.

(7) The Purchaser will not sell or otherwise transfer the Securities without
registration under the Securities Act and applicable state securities laws or an
applicable exemption therefrom. The Purchaser acknowledges that neither the
offer nor sale of the Securities has been registered under the Securities Act or
under the securities laws of any state. The Purchaser represents and warrants
that the Purchaser is acquiring the Securities for the Purchaser’s own account
and not with a view toward resale or distribution within the meaning of the
Securities Act. The Purchaser has not offered or sold the Securities being
acquired nor does the Purchaser have any present intention of selling,
distributing or otherwise disposing of such Securities either currently or after
the passage of a fixed or determinable period of time or upon the occurrence or
non-occurrence of any predetermined event or circumstances in violation of the
Securities Act. The Purchaser is aware that (i) the Securities are not currently
eligible for sale in reliance upon Rule 144 promulgated under the Securities Act
and (ii) the Company has no obligation to register the Securities subscribed for
hereunder, except as provided in Section E hereof. By making these
representations herein, Purchaser is not making any representation or agreement
to hold the Securities for any minimum or other specific term and reserves the
right to dispose of the Securities at any time in accordance with or pursuant to
a registration statement or an available exemption to the registration
requirements of the Securities Act.

(8) The Purchaser acknowledges that the certificates representing the Shares,
the Warrants and, upon the exercise of the Warrants, the shares of Common Stock
issuable upon exercise of the Warrants (the “Warrant Shares”), shall be stamped
or otherwise imprinted with a legend substantially in the following form:

The securities represented hereby have not been registered under the Securities
Act of 1933, as amended, or any state securities laws and neither the securities
nor any interest therein may be offered, sold, transferred, pledged or otherwise
disposed of except pursuant to an effective registration under such act or an
exemption from registration, which, in the opinion of counsel reasonably
satisfactory to this corporation, is available.

Certificates evidencing the Shares and the Warrant Shares shall not be required
to contain such legend or any other legend (i) following any sale of such Shares
or Warrant Shares pursuant to Rule 144, or (ii) if such Shares or Warrant Shares
are eligible for sale under Rule 144(k) or have been sold pursuant to the
Registration Statement (as defined in Section E hereof) and in

 

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compliance with the obligations set forth in Section E(6), below, or (iii) such
legend is not required under applicable requirements of the Securities Act
(including judicial interpretations and pronouncements issued by the Staff of
the Securities and Exchange Commission), in each such case (i) through (iii) to
the extent reasonably determined by the Company’s legal counsel. Subject to the
foregoing, at such time and to the extent a legend is no longer required for the
Shares or Warrant Shares, the Company will use its best efforts to no later than
three (3) trading days following the delivery by a Purchaser to the Company or
to the Company and the Company’s transfer agent of a legended certificate
representing such Shares or Warrant Shares (together with such accompanying
documentation or representations as reasonably required by counsel to the
Company), deliver or cause to be delivered a certificate representing such
Shares or Warrant Shares that is free from the foregoing legend.

If the Company shall fail to deliver or cause to be delivered for any reason or
no reason such unlegended certificate within the three (3) trading day period
set forth herein (the “Delivery Deadline”), then, in addition to all other
remedies available to the Purchaser, if on or after the trading day immediately
following the Delivery Deadline the Purchaser purchases (in an open market
transaction or otherwise) shares of Common Stock to deliver in satisfaction of a
sale by the Purchaser of shares of Common Stock that were to be represented by
the unlegended certificate (a “Buy-In”), then, provided as of such purchase date
the Purchaser had not received the unlegended certificate, the Company shall,
within three (3) business days after written request by the Purchaser and in the
Purchaser’s discretion, either (i) pay cash to the Purchaser in an amount equal
to the purchase price (including brokerage commissions, if any) paid by the
Purchaser for the shares of Common Stock so purchased (the “Buy-In Price”), at
which point the Company’s obligation to deliver such unlegended certificate (or
to issue such shares of Common Stock) shall terminate, and, in the case where
the shares that were to be represented by the unlegended certificate were
already issued to the Purchaser and held of record on the books of the Company’s
transfer agent, the Purchaser shall promptly deliver to the Company any
documentation reasonably required to transfer such shares from the Purchaser to
the Company, or (ii) promptly honor its obligation to deliver to the Purchaser a
certificate or certificates representing such shares of Common Stock and pay
cash to the Purchaser in an amount equal to the excess (if any) of the Buy-In
Price over the product of (A) such number of shares of Common Stock, times
(B) the Closing Sale Price on the Delivery Deadline. “Closing Sale Price” means,
for any security as of any date, the closing sale price for such security on the
OTC Bulletin Board, as reported by Bloomberg, or, if the OTC Bulletin Board
begins to operate on an extended hours basis and does not designate the closing
sale price then the last sale price of such security prior to 4:00:00 p.m., New
York time, as reported by Bloomberg, or, if the OTC Bulletin Board is not the
principal securities exchange or trading market for such security, the last sale
price of such security on the principal securities exchange or trading market
where such security is listed or traded as reported by Bloomberg, or if the
foregoing do not apply, the last sale price of such security in an
over-the-counter market on the electronic bulletin board for such security as
reported by Bloomberg, or, if no last sale price is reported for such security
by Bloomberg, the average of the ask prices of any market makers for such
security as reported in the “pink sheets” by Pink Sheets LLC (formerly the
National Quotation Bureau, Inc.). If the Closing Sale Price cannot be calculated
for a security on a particular date on any of the foregoing bases, the Closing
Sale Price of such security on such date shall be the fair market value as
mutually determined by the Company and the Purchaser. If the Company and the
Purchaser are unable to agree upon the fair market value of such security, then
such dispute shall be resolved pursuant to the dispute resolution provisions set
forth below. All such determinations shall be appropriately adjusted for any
stock dividend, stock split, stock combination or other similar transaction
during the applicable calculation period.

 

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In the case of a dispute as to the determination of the Closing Sale Price, the
Company shall submit the disputed determinations via facsimile within two
business days of receipt of the Purchaser’s written request giving rise to such
dispute to the Purchaser. If the Purchaser and the Company are unable to agree
upon such determination of the Closing Sale Price within three business days of
such disputed determination being submitted to the Purchaser, then the Company
shall, within two business days submit via facsimile the disputed determination
of the Closing Sale Price to an independent, reputable investment bank selected
by the Company and approved by the Purchaser. The Company, at the Company’s
expense, shall use reasonable best efforts to cause at its expense the
investment bank to perform the determinations and notify the Company and the
Purchaser of the results no later than ten business days from the time it
receives the disputed determinations. Such investment bank’s determination shall
be binding upon all parties absent demonstrable error.

(9) If this Agreement is executed and delivered on behalf of a partnership,
corporation, trust, estate or other entity: (i) such partnership, corporation,
trust, estate or other entity has the full legal right and power and all
authority and approval required (a) to execute and deliver this Agreement and
all other instruments executed and delivered by or on behalf of such
partnership, corporation, trust, estate or other entity in connection with the
purchase of its Securities, and (b) to purchase and hold such Securities;
(ii) the signature of the party signing on behalf of such partnership,
corporation, trust, estate or other entity is binding upon such partnership,
corporation, trust, estate or other entity; and (iii) such partnership,
corporation, trust or other entity has not been formed for the specific purpose
of acquiring such Securities, unless each beneficial owner of such entity is
qualified as an accredited investor within the meaning of Rule 501(a) of
Regulation D promulgated under the Securities Act and has submitted information
to the Company substantiating such individual qualification.

(10) If the Purchaser is a retirement plan or is investing on behalf of a
retirement plan, the Purchaser acknowledges that an investment in the Securities
poses additional risks, including the inability to use losses generated by an
investment in the Securities to offset taxable income.

(11) The information contained in the purchaser questionnaire in the form of
Exhibit C attached hereto (the “Purchaser Questionnaire”) delivered by the
Purchaser in connection with this Agreement is complete and accurate in all
respects, and the Purchaser is an “accredited investor” as defined in Rule 501
of Regulation D under the Securities Act on the basis indicated therein. The
Purchaser shall indemnify and hold harmless the Company and each officer,
director or control person, who is or may be a party or is or may be threatened
to be made a party to any threatened, pending or completed action, suit or
proceeding, whether civil, criminal, administrative or investigative, by reason
of or arising from any actual or alleged misrepresentation or misstatement of
facts or omission to represent or state facts made or alleged to have been made
by the Purchaser to the Company or omitted or alleged to have been omitted by
the Purchaser, concerning the Purchaser or the Purchaser’s authority to invest
or financial position in connection with the Offering, including, without
limitation, any such misrepresentation, misstatement or omission contained in
the Agreement or any other document submitted by the Purchaser, against losses,
liabilities and expenses for which the Company or any officer,

 

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director or control person has not otherwise been reimbursed (including
attorney’s fees, judgments, fines and amounts paid in settlement) actually and
reasonably incurred by the Company or such officer, director or control person
in connection with such action, suit or proceeding. For the avoidance of doubt,
such indemnification shall be the several, and not joint, obligation of each
Purchaser with respect to its own action or inaction as provided above.

(12) The information contained in the selling stockholder questionnaire in the
form of Exhibit D attached hereto (the “Selling Stockholder Questionnaire”)
delivered by the Purchaser in connection with this Agreement is complete and
accurate in all respects.

(13) The Purchaser acknowledges that the Company will have the authority to
issue shares of Common Stock, in excess of those being issued in connection with
the Offering, and that the Company may issue additional shares of Common Stock
from time to time. The issuance of additional shares of Common Stock may cause
dilution of the existing shares of Common Stock and a decrease in the market
price of such existing shares. The Purchaser acknowledges and agrees that the
Purchaser shall have no preemptive rights, right of first refusal, or other
rights to subscribe for or purchase any shares of Common Stock the Company may
issue in the future as a result of Purchaser’s purchase of Securities pursuant
to this Agreement.

(14) The Purchaser acknowledges that the Company has engaged the Placement Agent
in connection with the Offering and, as consideration for its services, has
agreed to pay the Placement Agent an aggregate cash commission equal to six and
one-half percent (6.5%) of the gross proceeds resulting from the Offering and
issue five-year warrants (the “Placement Agent Warrants”) to purchase such
number of shares of the Company’s Common Stock equal to six percent (6%) of the
aggregate Shares sold in the Offering.

 

C. Representations and Warranties of the Company

The Company hereby makes the following representations and warranties to the
Purchaser and the Placement Agent as of the date of this Agreement and
immediately prior to Closing:

(1) Organization, Good Standing and Qualification. The Company is a corporation
duly organized, validly existing and in good standing under the laws of the
State of Delaware and has full corporate power and authority to conduct its
business as currently conducted. The Company is duly qualified to do business as
a foreign corporation and is in good standing in all jurisdictions in which the
character of the property owned or leased or the nature of the business
transacted by it makes qualification necessary, except where the failure to be
so qualified would not have a material adverse effect on the business,
properties, assets, financial condition or results of operations of the Company
and its subsidiaries taken as a whole (a “Material Adverse Effect”).

(2) Capitalization. The authorized capital stock of the Company consists of
200,000,000 shares of Common Stock and 40,000,000 shares of preferred stock, par
value $0.0001 per share, of which 200,000 shares of preferred stock have been
designated Series A Junior Participating Preferred Stock and reserved for
issuance pursuant to the Company’s stockholder rights plan.

 

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As of January 29, 2007, there were (i) 32,251,549 shares of Common Stock and no
shares of preferred stock issued and outstanding; (ii) 5,665,856 shares of
Common Stock reserved for issuance to employees, directors and consultants
pursuant to the Company’s 2005 Equity Incentive Plan, of which 3,580,000 shares
of Common Stock were subject to outstanding options; (iii) 1,885,000 shares of
Common Stock reserved for issuance to employees, directors and consultants of
the Company’s subsidiaries pursuant to warrants issued outside the Company’s
2005 Equity Incentive Plan, of which 1,724,000 shares of Common Stock were
subject to outstanding, warrants; (iv) 2,209,757 shares of Common Stock reserved
for issuance pursuant to other outstanding warrants to purchase Common Stock;
and (v) 2,000,000 shares of Common Stock reserved for issuance in the event of a
failure to meet certain commercial development milestones resulting from the
Company’s acquisition of Tissue Repair Company. Other than as set forth above or
as contemplated in this Agreement, there are no other options, warrants, calls,
rights, commitments or agreements of any character to which the Company is a
party or by which either the Company is bound or obligating the Company to
issue, deliver, sell, repurchase or redeem, or cause to be issued, delivered,
sold, repurchased or redeemed, any shares of the capital stock of the Company or
obligating the Company to grant, extend or enter into any such option, warrant,
call, right, commitment or agreement.

(3) Issuance; Reservation of Shares. The issuance of the Shares has been duly
and validly authorized by all necessary corporate and stockholder action, and
the Shares, when issued and paid for pursuant to this Agreement, will be validly
issued, fully paid and non-assessable shares of Common Stock of the Company. The
issuance of the Warrants has been duly and validly authorized by all necessary
corporate and stockholder action, and the Warrant Shares, when issued upon the
due exercise of the Warrants, will be validly issued, fully paid and
non-assessable shares of Common Stock of the Company. The Company has reserved,
and will reserve, at all times that the Warrants or Placement Agent Warrants
remain outstanding, such number of shares of Common Stock sufficient to enable
the full exercise of the then outstanding Warrants and Placement Agent Warrants.

(4) Authorization; Enforceability. The Company has all corporate right, power
and authority to enter into this Agreement and to consummate the transactions
contemplated hereby. All corporate action on the part of the Company, its
directors and stockholders necessary for the authorization, execution, delivery
and performance of this Agreement by the Company, the authorization, sale,
issuance and delivery of the Securities contemplated herein and the performance
of the Company’s obligations hereunder has been taken. This Agreement has been
duly executed and delivered by the Company and constitutes the legal, valid and
binding obligation of the Company, enforceable against the Company in accordance
with its terms and subject to laws of general application relating to
bankruptcy, insolvency and the relief of debtors and rules of law governing
specific performance, injunctive relief or other equitable remedies, and to
limitations of public policy. The issuance and sale of the Securities
contemplated hereby will not give rise to any preemptive rights or rights of
first refusal on behalf of any person.

 

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(5) No Conflict; Governmental and Other Consents.

(a) The execution and delivery by the Company of this Agreement and the
consummation of the transactions contemplated hereby will not result in the
violation of any law, statute, rule, regulation, order, writ, injunction,
judgment or decree of any court or governmental authority to or by which the
Company is bound, or of any provision of the Certificate of Incorporation or
Bylaws of the Company, and will not conflict with, or result in a breach or
violation of, any of the terms or provisions of, or constitute (with due notice
or lapse of time or both) a default under, any lease, loan agreement, mortgage,
security agreement, trust indenture or other agreement or instrument to which
the Company is a party or by which it is bound or to which any of its properties
or assets is subject, nor result in the creation or imposition of any lien upon
any of the properties or assets of the Company except to the extent that any
such violation, conflict or breach would not be reasonably likely to have a
Material Adverse Effect. No holder of any of the securities of the Company or
any of its subsidiaries has any rights (“demand,” “piggyback” or otherwise) to
have such securities registered by reason of the intention to file, filing or
effectiveness of a Registration Statement.

(b) Except for the approval of the National Association of Securities Dealers
(the “NASD”), no consent, approval, authorization or other order of any
governmental authority or other third-party is required to be obtained by the
Company in connection with the authorization, execution and delivery of this
Agreement or with the authorization, issue and sale of the Securities, except
such post-Closing filings as may be required to be made with the Securities and
Exchange Commission (the “SEC”), NASD, and with any state or foreign blue sky or
securities regulatory authority.

(6) Litigation. There are no pending or, to the Company’s knowledge, threatened
legal or governmental proceedings against the Company, which, if adversely
determined, would be reasonably likely to have a Material Adverse Effect. There
is no action, suit, proceeding, inquiry or investigation before or by any court,
public board or body (including, without limitation, the SEC) pending or, to the
knowledge of the Company, threatened against or affecting the Company or any of
its subsidiaries wherein an unfavorable decision, ruling or finding could
adversely affect the validity or enforceability of, or the authority or ability
of the Company to perform its obligations under this Agreement.

(7) Accuracy of Reports. All reports required to be filed by the Company in the
period commencing October 20, 2005 and ending on the date of this Agreement (the
“SEC Reports”) under the Securities Exchange Act of 1934, as amended (the
“Exchange Act”), have been filed with the SEC, complied at the time of filing in
all material respects with the requirements of their respective forms and,
except to the extent updated or superseded by any subsequently filed report,
were complete and correct in all material respects as of the dates at which the
information was furnished, and contained (as of such dates) no untrue statements
of a material fact nor omitted to state any material fact necessary in order to
make the statements contained therein, in light of the circumstances under which
they were made, not misleading. To the Company’s knowledge, all reports required
to be filed by the Company in the period commencing two years prior to the date
of this Agreement and ending October 20, 2005 under Exchange Act have been filed
with the SEC, complied at the time of filing in all material respects with the
requirements of their respective forms and, except to the extent updated or
superseded by any subsequently filed report, were complete and correct in all
material respects as of the dates at

 

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which the information was furnished, and contained (as of such dates) no untrue
statements of a material fact nor omitted to state any material fact necessary
in order to make the statements contained therein, in light of the circumstances
under which they were made, not misleading.

(8) Financial Information. The Company’s financial statements that appear in the
SEC Reports have been prepared in accordance with United States generally
accepted accounting principles (“GAAP”), except in the case of unaudited
statements, as permitted by Form 10-QSB of the SEC or as may be indicated
therein or in the notes thereto, applied on a consistent basis throughout the
periods indicated and such financial statements fairly present in all material
respects the financial condition and results of operations of the Company as of
the dates and for the periods indicated therein.

(9) Accounting Controls. The Company maintains a system of internal accounting
controls sufficient to provide reasonable assurances that (i) transactions are
executed in accordance with management’s general or specific authorization;
(ii) transactions are recorded as necessary to permit preparation of financial
statements in conformity with GAAP and to maintain accountability for assets;
(iii) access to assets is permitted only in accordance with management’s general
or specific authorization; and (iv) the recorded accountability for assets is
compared with existing assets at reasonable intervals and appropriate action is
taken with respect to any differences.

(10) Sarbanes-Oxley Act of 2002. The Company is, and will be, at all times
during the period the Company must maintain effectiveness of the Registration
Statement as provided herein, in compliance, in all material respects, with all
applicable provisions of the Sarbanes-Oxley Act of 2002 and all rules and
regulations promulgated thereunder or implementing the provisions thereof that
are in effect and is taking reasonable steps to ensure that it will be in
compliance with other applicable provisions of the Sarbanes-Oxley Act of 2002
not currently in effect upon the effectiveness of such provisions.

(11) Absence of Certain Changes. Since the date of the Company’s financial
statements in the latest of the SEC Reports containing financial statements of
the Company, there has not occurred any undisclosed event that has caused a
Material Adverse Effect or any occurrence, circumstance or combination thereof
that reasonably would be likely to result in such Material Adverse Effect.

(12) Investment Company. The Company is not an “investment company” within the
meaning of such term under the Investment Company Act of 1940, as amended, and
the rules and regulations of the SEC thereunder.

(13) Subsidiaries. The Company has three wholly-owned subsidiaries, Innercool
Therapies, Inc., Aries Ventures, Inc. and Tissue Repair Company (collectively
referred to herein as the Company’s “subsidiaries”). Each of the Company’s
subsidiaries has been duly incorporated in the State of Delaware, is validly
existing as a corporation in good standing under Delaware law, has the corporate
power and authority to own its property and to conduct its business as described
in the Offering Materials and is duly qualified to transact business and is in
good standing in each jurisdiction in which the conduct of its business or its
ownership or leasing of property requires such qualification, except to the
extent that the failure to be so qualified or be in good standing would not have
a Material Adverse Effect.

 

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(14) Indebtedness. The financial statements in the SEC Reports reflect, to the
extent required, as of the date thereof all outstanding secured and unsecured
Indebtedness (as defined below) of the Company or any subsidiary, or for which
the Company or any subsidiary has commitments. For purposes of this Agreement,
“Indebtedness” shall mean (a) any liabilities for borrowed money or amounts owed
(other than trade accounts payable incurred in the ordinary course of business),
(b) all guaranties, endorsements and other contingent obligations in respect of
Indebtedness of others, whether or not the same are or should be reflected in
the Company’s balance sheet (or the notes thereto), except guaranties by
endorsement of negotiable instruments for deposit or collection or similar
transactions in the ordinary course of business; and (c) the present value of
any lease payments due under leases required to be capitalized in accordance
with GAAP. The Company is not in default with respect to any Indebtedness. The
Company is not insolvent and will not be insolvent after giving effect to the
transactions contemplated herein. For purposes of this Paragraph (14),
“insolvent” shall mean an inability to pay debts when due.

(15) Certain Fees. Other than fees payable to the Placement Agent and National
Securities Corporation, no brokers’, finders’ or financial advisory fees or
commissions will be payable by the Company with respect to the transactions
contemplated by this Agreement.

(16) Material Agreements. Except as set forth in the SEC Reports, the Company is
not a party to any written or oral contract, instrument, agreement, commitment,
obligation, plan or arrangement, a copy of which would be required to be filed
with the SEC as an exhibit to Form 10-KSB (each, a “Material Agreement”). The
Company and each of its subsidiaries has in all material respects performed all
the obligations required to be performed by them to date under the foregoing
agreements, have received no notice of default by the Company or the subsidiary
that is a party thereto, as the case may be, and, to the Company’s knowledge,
are not in default under any Material Agreement now in effect, the result of
which would be reasonably likely to have a Material Adverse Effect.

(17) Transactions with Affiliates. Except as set forth in the SEC Reports, there
are no loans, leases, agreements, contracts, royalty agreements, management
contracts or arrangements or other continuing transactions between (a) the
Company or any of its customers or suppliers on the one hand, and (b) on the
other hand, any person who would be covered by Item 404(a) of Regulation S-B or
any company or other entity controlled by such person.

(18) Taxes. The Company has prepared and filed all federal, state, local,
foreign and other tax returns for income, gross receipts, sales, use and other
taxes and custom duties (“Taxes”) required by law to be filed by it, except for
tax returns, the failure to file which, individually or in the aggregate, do not
and would not have a Material Adverse Effect. Such filed tax returns are
complete and accurate, except for such omissions and inaccuracies, which
individually or in the aggregate, could not reasonably be expected to have a
Material Adverse Effect. The Company has paid or made provisions for the payment
of all Taxes shown to be due on such tax returns and all additional assessments,
and adequate provisions have been and are reflected in the financial statements
of the Company and the subsidiaries for all current Taxes to which the Company
or any subsidiary is subject and which are not currently due and

 

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payable, except for such Taxes which, if unpaid, individually or in the
aggregate, do not and would not have a Material Adverse Effect. None of the
federal income tax returns of the Company for the past five years has been
audited by the Internal Revenue Service. The Company has not received written
notice of any assessments, adjustments or contingent liability (whether federal,
state, local or foreign) in respect of any Taxes pending or threatened against
the Company or any subsidiary for any period which, if unpaid, would have a
Material Adverse Effect.

(19) Insurance. The Company is insured by insurers of recognized financial
responsibility against such losses and risks and in such amounts as the Company
believes are prudent and customary in the businesses in which the Company is
engaged. The Company has no reason to believe that it will not be able to renew
its existing insurance coverage as and when such coverage expires or to obtain
similar coverage from similar insurers as may be necessary to continue its
business without an increase in cost significantly greater than general
increases in cost experienced for similar companies in similar industries with
respect to similar coverage.

(20) Environmental Matters. Except as disclosed in the SEC Reports, to the
Company’s knowledge, all real property owned, leased or otherwise operated by
the Company is free of contamination from any substance, waste or material
currently identified to be toxic or hazardous pursuant to, within the definition
of a substance which is toxic or hazardous under, or which may result in
liability under, any Environmental Law (as defined below), including, without
limitation, any asbestos, polychlorinated biphenyls, radioactive substance,
methane, volatile hydrocarbons, industrial solvents, oil or petroleum or
chemical liquids or solids, liquid or gaseous products, or any other material or
substance (“Hazardous Substance”) which has caused or would reasonably be
expected to cause or constitute a threat to human health or safety, or an
environmental hazard in violation of Environmental Law or to result in any
environmental liabilities that would be reasonably likely to have a Material
Adverse Effect. The Company has not caused or suffered to occur any release,
spill, migration, leakage, discharge, disposal, uncontrolled loss, seepage, or
filtration of Hazardous Substances that would reasonably be expected to result
in environmental liabilities that would be reasonably likely to have a Material
Adverse Effect. The Company has generated, treated, stored and disposed of any
Hazardous Substances in compliance with applicable Environmental Laws, except
for such non-compliances that would not be reasonably likely to have a Material
Adverse Effect. The Company has obtained, or has applied for, and is in
compliance with and in good standing under all permits required under
Environmental Laws (except for such failures that would not be reasonably likely
to have a Material Adverse Effect) and the Company has no knowledge of any
proceedings to substantially modify or to revoke any such permit. There are no
investigations, proceedings or litigation pending or, to the Company’s
knowledge, threatened against the Company or any of the Company’s facilities
relating to Environmental Laws or Hazardous Substances. “Environmental Laws”
shall mean all federal, national, state, regional and local laws, statutes,
ordinances and regulations, in each case as amended or supplemented from time to
time, and any judicial or administrative interpretation thereof, including
orders, consent decrees or judgments relating to the regulation and protection
of human health, safety, the environment and natural resources.

(21) Intellectual Property Rights and Licenses. The Company owns or has the
right to use any and all information, know-how, trade secrets, patents,
copyrights, trademarks, trade names, software, formulae, methods, processes and
other intangible

 

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properties that are of a such nature and significance to the business that the
failure to own or have the right to use such items would have a Material Adverse
Effect (“Intangible Rights”). The Company has not received any notice that it is
in conflict with or infringing upon the asserted intellectual property rights of
others in connection with the Intangible Rights, and, to the Company’s
knowledge, neither the use of the Intangible Rights nor the operation of the
Company’s businesses is infringing or has infringed upon any intellectual
property rights of others in a manner that would be reasonably expected to have
a Material Adverse Effect. All payments have been duly made that are necessary
to maintain the Intangible Rights in force. No claims have been made, and to the
Company’s knowledge, no claims are threatened, that challenge the validity or
scope of any material Intangible Right of the Company. The Company has taken
reasonable steps to obtain and maintain in force all licenses and other
permissions under Intangible Rights of third parties necessary to conduct their
businesses as heretofore conducted by them, and now being conducted by them, and
as expected to be conducted, and the Company is not or has not been in material
breach of any such license or other permission.

(22) Labor, Employment and Benefit Matters.

(a) There are no existing, or to the best of the Company’s knowledge, threatened
strikes or other labor disputes against the Company that would be reasonably
likely to have a Material Adverse Effect. Except as set forth in the SEC
Reports, there is no organizing activity involving employees of the Company
pending or, to the Company’s or its subsidiaries’ knowledge, threatened by any
labor union or group of employees. There are no representation proceedings
pending or, to the Company’s knowledge, threatened with the National Labor
Relations Board, and no labor organization or group of employees of the Company
or its subsidiaries has made a pending demand for recognition.

(b) Except as set forth in the SEC Reports, the Company is not, or during the
five years preceding the date of this Agreement was not, a party to any labor or
collective bargaining agreement and there are no labor or collective bargaining
agreements which pertain to employees of the Company.

(c) Each employee benefit plan is in compliance with all applicable law, except
for such noncompliance that would not be reasonably likely to have a Material
Adverse Effect.

(d) The Company does not have any liabilities, contingent or otherwise,
including without limitation, liabilities for retiree health, retiree life,
severance or retirement benefits, which are not fully reflected, to the extent
required by GAAP, on the Balance Sheet or fully funded. The term “liabilities”
used in the preceding sentence shall be calculated in accordance with reasonable
actuarial assumptions.

(e) The Company has not (i) terminated any “employee pension benefit plan” as
defined in Section 3(2) of ERISA (as defined below) under circumstances that
present a material risk of the Company or any of its subsidiaries incurring any
liability or obligation that would be reasonably likely to have a Material
Adverse Effect, or (ii) incurred or expects to incur any outstanding liability
under Title IV of the Employee Retirement Income Security Act of 1974, as
amended and all rules and regulations promulgated thereunder (“ERISA”).

 

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(23) Compliance with Law. To the best of the Company’s knowledge, the Company is
in compliance in all material respects with all applicable laws, except for such
noncompliance that would not reasonably be likely to have a Material Adverse
Effect. The Company has not received any notice of, nor does the Company have
any knowledge of, any violation (or of any investigation, inspection, audit or
other proceeding by any governmental entity involving allegations of any
violation) of any applicable law involving or related to the Company which has
not been dismissed or otherwise disposed of that would be reasonably likely to
have a Material Adverse Effect. The Company has not received notice or otherwise
has any knowledge that the Company is charged with, threatened with or under
investigation with respect to, any violation of any applicable law that would
reasonably be likely to have a Material Adverse Effect. Neither the Company nor
any of its subsidiaries nor any employee or agent of the Company or any
subsidiary has made any contribution or other payment to any official of, or
candidate for, any federal, state or foreign office in violation of any law. The
Company and its directors, officers, employees and agents have complied in all
material respects with the Foreign Corrupt Practices Act of 1977, as amended,
and any related rules and regulations.

(24) Ownership of Property. Except as set forth in the Company’s financial
statements included in the SEC Reports, the Company and has (i) good and
marketable fee simple title to its owned real property, if any, free and clear
of all liens, except for liens which do not individually or in the aggregate
have a Material Adverse Effect; (ii) a valid leasehold interest in all leased
real property, and each of such leases is valid and enforceable in accordance
with its terms (subject to laws of general application relating to bankruptcy,
insolvency and the relief of debtors and rules of law governing specific
performance, injunctive relief or other equitable remedies, and to limitations
of public policy) and is in full force and effect, and (iii) good title to, or
valid leasehold interests in, all of its other properties and assets free and
clear of all liens, except for liens disclosed in the SEC Reports or which
otherwise do not individually or in the aggregate have a Material Adverse
Effect.

(25) Compliance with OTC Bulletin Board Requirements. The Company’s Common Stock
is registered pursuant to Section 12(b) of the Exchange Act and is eligible to
be quoted on the OTC Bulletin Board, trading in the Common Stock has not been
suspended, and the Company has taken no action designed to, or likely to have
the effect of, terminating the registration of the Common Stock under the
Exchange Act or disqualifying the Common Stock from quotation on the OTC
Bulletin Board, nor to the Company’s knowledge is NASD currently contemplating
terminating the eligibility of the Company’s Common Stock to be quoted on the
OTC Bulletin Board. The Company and the Common Stock meet the criteria for
continued quotation on the OTC Bulletin Board.

(26) No Integrated Offering. Assuming the accuracy of each Purchaser’s
representations and warranties set forth in Section B hereof, neither the
Company, nor any of its affiliates or other person acting on the Company’s
behalf has, directly or indirectly, made any offers or sales of any security or
solicited any offers to buy any security under circumstances that would cause
the Offering of the Securities to be integrated with prior offerings by the
Company for purposes of the Securities Act, when integration would cause the
Offering not to be exempt from the requirements of Section 5 of the Securities
Act.

 

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(27) General Solicitation. Neither the Company nor, its knowledge, any person
acting on behalf of the Company, has offered or sold any of the Securities by
any form of “general solicitation” within the meaning of Rule 502 under the
Securities Act. To the knowledge of the Company, no person acting on its behalf
has offered the Securities for sale other than to the Purchasers and certain
other “accredited investors” within the meaning of Rule 501 under the Securities
Act.

(28) No Manipulation of Stock. The Company has not taken and will not take, in
violation of applicable law, any action designed to or that might reasonably be
expected to cause or result in stabilization or manipulation of the price of the
Common Stock to facilitate the sale or resale of the Securities.

(29) No Registration. Assuming the accuracy of the representations and
warranties made by, and compliance with the covenants of, the Purchasers in
Section B hereof, no registration of the Securities under the Securities Act is
required in connection with the offer and sale of the Securities by the Company
to the Purchasers as contemplated by this Agreement.

(30) Form D. The Company agrees to file one or more Forms D with respect to the
Securities on a timely basis as required under Regulation D under the Securities
Act to claim the exemption provided by Rule 506 of Regulation D and to provide a
copy thereof to the Purchasers and their counsel promptly after such filing.

(31) Certain Future Financings and Related Actions. The Company will not sell,
offer to sell, solicit offers to buy or otherwise negotiate in respect of any
“security” (as defined in the Securities Act) that is or could be integrated
with the sale of the Securities in a manner that would require the registration
of the Securities under the Securities Act.

(32) Use of Proceeds. The Company intends that the net proceeds from the
Offering will be used to fund the continued development of its product
candidates (including, without limitation, expenses relating to conducting
clinical trials and research and development spending), strategic acquisitions
or corporate development transactions and general corporate purposes; provided,
that the Company has and shall retain broad discretion with regard to the use of
such proceeds and nothing herein or in the Offering Materials shall be construed
as to restrict the Company’s ability to apply such proceeds in a manner
different than set forth above.

(33) Disclosure. The Company understands and acknowledges that each of the
Purchasers will rely on the foregoing representations in effecting transactions
in securities of the Company. All disclosure provided by the Company to the
Purchasers regarding the Company, its business and the transactions contemplated
hereby furnished by or on the behalf of the Company are true and correct in all
material respects and do not contain any untrue statement of a material fact or
omit to state any material fact necessary in order to make the statements made
therein, in the light of the circumstances under which they were made, not
misleading. To the Company’s knowledge, no material event or circumstance has
occurred or information exists with respect to the Company or its business,
properties, operations or financial conditions, which, under applicable law,
rule or regulation, requires public disclosure or announcement by the Company
but which has not been so publicly announced or disclosed.

 

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D. Understandings

Each of the Purchasers understands, acknowledges and agrees with the Company as
follows:

(1) The execution of this Agreement by the Purchaser or solicitation of the
investment contemplated hereby shall create no obligation on the part of the
Company to accept any subscription or complete the Offering. If the Company
accepts a subscription for Securities made by a Purchaser, it shall countersign
this Agreement within one (1) business day of its receipt thereof. If this
Agreement is not countersigned within one (1) business day of the Company’s
receipt thereof, the Purchaser shall have the option to withdraw its investment
by delivering written notice thereof to the Company. This Agreement, however,
shall remain valid unless and until the Company has received such written notice
of withdrawal. Notwithstanding such option, the Company may terminate this
Offering or reject any subscription at any time in its sole discretion. Each
Purchaser hereby acknowledges and agrees that the subscription hereunder, once
accepted by the Company, is irrevocable by such Purchaser, and that, except as
required by law, such Purchaser is not entitled to cancel, terminate or revoke
this Agreement or any agreements of such Purchaser hereunder, except that the
obligations under this Agreement shall not survive the death or disability of
the Purchaser.

(2) No federal or state agency or authority has made any finding or
determination as to the accuracy or adequacy of the Offering Documents or as to
the fairness of the terms of the Offering nor any recommendation or endorsement
of the Securities. Any representation to the contrary is a criminal offense. In
making an investment decision, Purchasers must rely on their own examination of
the Company and the terms of the Offering, including the merits and risks
involved.

(3) The Offering is intended to be exempt from registration under the Securities
Act by virtue of Section 4(2) of the Securities Act and the provisions of Rule
506 of Regulation D thereunder, which is in part dependent upon the truth,
completeness and accuracy of the statements made by the Purchaser herein and in
the Purchaser Questionnaire.

(4) Notwithstanding the registration obligations provided herein, there can be
no assurance that the Purchaser will be able to sell or dispose of the
Securities. It is understood that in order not to jeopardize the Offering’s
exempt status under Section 4(2) of the Securities Act and Regulation D, any
transferee may, at a minimum, be required to fulfill the investor suitability
requirements thereunder.

(5) The Purchaser acknowledges that the Offering is confidential and non-public
and agrees that all information about the Offering shall be kept in confidence
by the Purchaser until the public announcement of the Offering by the Company.
The Purchaser acknowledges that the foregoing restrictions on the Purchaser’s
use and disclosure of any such confidential, non-public information contained in
the above-described documents restricts the Purchaser from trading in the
Company’s securities to the extent such trading

 

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is on the basis of material, non-public information of which the Purchaser is
aware. Except for the terms of the transaction documents and the fact that the
Company is considering consummating the transactions contemplated therein (which
information the Company has agreed to disclose in accordance with Section F.3
hereof), the Company confirms that neither the Company nor, to its knowledge,
any other person acting on its behalf, has provided any of the Purchasers or
their agents or counsel with any information that constitutes material,
non-public information.

(6) The Purchaser agrees that beginning on the date hereof until the Offering is
publicly announced by the Company (which the Company has agreed to undertake in
accordance with the provisions of Section F.3. hereof), the Purchaser will not
enter into any Short Sales. For purposes of the foregoing sentence, a “Short
Sale” by a Purchaser means a sale of Common Stock that is marked as a short sale
and that is executed at a time when such Purchaser has no equivalent offsetting
long position in the Common Stock, exclusive of the Shares. For purposes of
determining whether a Purchaser has an equivalent offsetting long position in
the Common Stock, all Common Stock that would be issuable upon exercise in full
of all options then held by such Purchaser (assuming that such options were then
fully exercisable, notwithstanding any provisions to the contrary, and giving
effect to any exercise price adjustments scheduled to take effect in the future)
shall be deemed to be held long by such Purchaser. Each Purchaser understands
and acknowledges that the SEC currently takes the position that coverage of
Short Sales “against the box” prior to the Effective Date of the Registration
Statement is a violation of Section 5 of the Securities Act, as set forth in
Item 65, Section A, of the Manual of Publicly Available Telephone
Interpretations, dated July 1997, complied by the Office of Chief Counsel,
Division of Corporation Finance.

 

E. Registration Rights

(1) Certain Definitions. For purposes of this Section E, the following terms
shall have the meanings ascribed to them below.

(a) “Prospectus” means the prospectus included in the Registration Statement
(including, without limitation, a prospectus that includes any information
previously omitted from a prospectus filed as part of an effective registration
statement in reliance upon Rule 430A promulgated under the Securities Act), as
amended or supplemented by any prospectus supplement, with respect to the terms
of the Offering of any portion of the Registrable Securities covered by the
Registration Statement, and all other amendments and supplements to the
Prospectus, including post-effective amendments, and all material incorporated
by reference or deemed to be incorporated by reference in such Prospectus.

(b) “Registrable Securities” shall mean any Shares and Warrant Shares issued or
issuable pursuant to the Offering Documents together with any securities issued
or issuable upon any stock split, dividend or other distribution, adjustment,
recapitalization or similar event with respect to the foregoing.

(c) “Registration Statement” means the registration statement required to be
filed under this Section E, including the Prospectus, amendments and supplements
to such registration statement or Prospectus, including pre- and post-effective
amendments, all exhibits thereto, and all material incorporated by reference or
deemed to be incorporated by reference in such registration statement.

 

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(2) Shelf Registration.

(a) The Company shall use its best efforts to cause to prepare and file with the
SEC a “Shelf” Registration Statement covering the resale of all Registrable
Securities for an offering to be made on a continuous basis pursuant to Rule 415
under the Securities Act on or prior to the 30th day (the “Filing Default Date”)
following the Closing (such date of actual filing, the “Filing Date”). The
Registration Statement shall be on Form S-3; provided that if the Company shall
determine in good faith that Form S-3 is not then available to it, the
Registration Statement shall be on Form S-1. The Registration Statement shall
contain (except if otherwise directed in writing by the Purchasers) a “Plan of
Distribution” substantially in the form attached hereto as Exhibit E. Each
Purchaser will furnish to the Company, within five days of the Closing, a
completed questionnaire in the form set forth as Exhibit D hereto. Each
Purchaser agrees to promptly update such questionnaire in order to make the
information previously furnished to the Company by such Purchaser complete and
not materially misleading. The Registration Statement shall register the
Registrable Securities for resale by the holders thereof.

(b) The Company shall use its best efforts to cause the Registration Statement
to be declared effective by the SEC on or prior to the 90th day following the
Closing (the “No-Review Effectiveness Default Date”) if there is no SEC review
of the Registration Statement or the 120th day following the Closing (the
“SEC-Review Effectiveness Default Date”) in the event of an SEC review of the
Registration Statement, and shall use its best efforts to keep the Registration
Statement continuously effective under the Securities Act until the earliest of
(i) the second anniversary of the Closing or (ii) the date when all Registrable
Securities covered by such Registration Statement have been sold (the
“Effectiveness Period”).

(c) The Company shall request effectiveness of the Registration Statement (and
any post-effective amendments thereto) within five (5) business days following
the Company’s receipt of notice from the SEC that the Registration Statement
will not be reviewed by the SEC or that the SEC has completed its review of such
Registration Statement and has no further comments. The Company shall request
effectiveness of the Registration Statement (and any post-effective amendments
thereto) at 5:00 p.m., Eastern time, on the effective date, and file with the
SEC and deliver the Prospectus (or any supplements thereto), which delivery may
be made electronically, by 8:00 a.m. Eastern time on the business day after such
effective date.

(d) Upon the occurrence of any Event (as defined below), as partial relief for
the damages suffered therefrom by the Purchasers (which remedy shall not be
exclusive of any other remedies which are available at law or in equity; and
provided further that the Purchasers shall be entitled to pursue an action for
specific performance of the Company’s obligations under Paragraph (2)(b) above
and any such actions at law, in equity, for specific performance or
otherwise shall not require the Purchaser to post a bond), the Company shall pay
to each Purchaser, as liquidated damages and not as a penalty (it being agreed
that it would not be feasible to ascertain the extent of such damages with
precision), such amounts and at such times as shall be determined pursuant to
this Paragraph (2)(d). For such purposes, each of the following shall constitute
an “Event”:

(i) the Filing Date does not occur on or prior to the Filing Default Date, in
which case the Company shall pay to each Purchaser an amount in cash equal to
one-thirtieth of one percent of the aggregate purchase price paid by such
Purchaser for each day from the Filing Default Date until the Filing Date,
payable at the end of each 30-day period after the Filing Default Date; or

 

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(ii) (A) there is no SEC review of the Registration Statement and the
Registration Statement is not declared effective on or prior to the No-Review
Effectiveness Default Date, in which case the Company shall pay to each
Purchaser for each day after the No-Review Effectiveness Default Date until the
date upon which the Registration Statement is first declared effective, an
amount in cash equal to one-thirtieth of one percent of the aggregate purchase
price paid by such Purchaser; or (B) there is an SEC review of the Registration
Statement and the Registration Statement is not declared effective on or prior
to the SEC-Review Effectiveness Default Date, in which case the Company shall
pay to each Purchaser an amount in cash equal to one-thirtieth of one percent of
the aggregate purchase price paid by such Purchaser for each day after the
SEC-Review Effectiveness Default Date until the date the Registration Statement
is first declared effective, in each case payable at the end of each 30-day
period after the No-Review Effectiveness Default Date or SEC-Review
Effectiveness Default Date, as applicable; or

(iii) if during the Effectiveness Period, the SEC issues any stop order
suspending the effectiveness of the Registration Statement, in which case the
Company shall pay to each Purchaser for each day after the issuance of such SEC
stop order until the date upon which the Registration Statement is again
declared effective or the end of the Effectiveness Period, whichever is earlier,
an amount in cash equal to one-thirtieth of one percent of the aggregate
purchase price paid by such Purchaser with respect to any Shares not previously
sold or transferred by such Purchaser pursuant to the Registration Statement as
of the time of the issuance of the stop order, payable at the end of each 30-day
period after the issuance of the SEC stop order.

The payment obligations of the Company under this Section E(2)(d) shall be
cumulative. If any payment under this Section E(2)(d) is not received by the
Purchasers when such payment is due, then in addition to any other remedies that
may be available to the Purchasers, interest at the rate of 1% per 30-day period
(prorated for periods less than 30 days) shall accrue on the outstanding balance
of the delinquent payment until such delinquent payment is paid in full.

(e) The Purchasers acknowledge that the SEC has recently given enhanced scrutiny
to registration statements attempting to register the resale of shares and
warrant shares obtained by purchasers in private placements and that such SEC
reviews have resulted in registrants being denied the use of Rule 415(a)(1)(i).
Accordingly, notwithstanding anything herein to the contrary, the Purchasers
agree that (i) the Company shall not be obligated to pay any amount of
liquidated damages under Section (E)(2)(d)(ii)(B) in the event the Registration
Statement is not declared effective on or prior to the SEC-Review Effectiveness
Default Date solely as a result of or in connection with a determination by the
SEC that either the Company or the Purchasers are ineligible to rely on Rule
415(a)(1)(i) under the Securities Act with respect to the registration of any of
the Registrable Securities for resale by the Purchasers on a continuous or
delayed basis; provided, that the Company shall thereafter use its commercially
reasonable efforts to find alternative

 

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methods to register the Registrable Securities with the SEC for resale; and
(ii) in the event the Company, after conducting a pre-filing conference with the
SEC, if possible, and after consultation with the Placement Agent, reasonably
determines that it is unable to, or it is inadvisable for the Company to attempt
to, register all of the Registrable Securities in a single Registration
Statement, the Company may elect to fulfill the registration requirements of
this Section (E)(2) by registering the Registrable Securities in two or more
Registration Statements, provided that the Company shall use its best efforts to
file each subsequent Registration Statement no later than the earlier of (A) 60
days following the date on which the last of the Registrable Securities
registered under the preceding Registration Statement were sold or (B) 6 months
following the date on which the preceding Registration Statement was declared
effective.

(3) Registration Procedures. In connection with the Company’s registration
obligations hereunder, the Company shall:

(a) Use its best efforts to (i) prepare and file with the SEC such amendments,
including post-effective amendments, to the Registration Statement as may be
necessary to keep the Registration Statement continuously effective as to the
Registrable Securities for the Effectiveness Period; (ii) cause the related
Prospectus to be amended or supplemented by any required Prospectus supplement,
and as so supplemented or amended to be filed pursuant to Rule 424; and
(iii) respond as promptly as reasonably possible, and in any event within ten
(10) trading days, to any comments received from the SEC with respect to the
Registration Statement or any amendment thereto and as promptly as reasonably
possible provide the Placement Agent true and complete copies of all
correspondence from and to the SEC relating to the Registration Statement.

(b) Notify the Placement Agent and the Purchasers as promptly as reasonably
possible, and (if requested by the Placement Agent) confirm such notice in
writing no later than one (1) trading day thereafter, of any of the following
events: (i) the SEC notifies the Company whether there will be a “review” of the
Registration Statement; (ii) the SEC comments in writing on the Registration
Statement (in which case the Company shall deliver to the Placement Agent a copy
of such comments and of all written responses thereto); (iii) the SEC or any
other Federal or state governmental authority in writing requests any amendment
or supplement to the Registration Statement or Prospectus or requests additional
information related thereto; (iv) if the SEC issues any stop order suspending
the effectiveness of the Registration Statement or initiates any action, claim,
suit, investigation or proceeding (a “Proceeding”) for that purpose; (v) the
Company receives notice in writing of any suspension of the qualification or
exemption from qualification of any Registrable Securities for sale in any
jurisdiction, or the initiation or threat of any Proceeding for such purpose; or
(vi) the financial statements included in the Registration Statement become
ineligible for inclusion therein or any statement made in the Registration
Statement or Prospectus or any document incorporated or deemed to be
incorporated therein by reference is untrue in any material respect or any
revision to the Registration Statement, Prospectus or other document is required
so that it will not contain any untrue statement of a material fact or omit to
state any material fact required to be stated therein or necessary to make the
statements therein, in light of the circumstances under which they were made,
not misleading. Notwithstanding the foregoing, the Company shall not include any
material non-public information in any notice provided to any Purchaser under
this Section E(3)(b).

 

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(c) Use its best efforts to avoid the issuance of or, if issued, obtain the
prompt withdrawal of (i) any order suspending the effectiveness of the
Registration Statement or (ii) any suspension of the qualification (or exemption
from qualification) of any of the Registrable Securities for sale in any
jurisdiction.

(d) Use its best efforts to deliver to each Purchaser, which delivery may be
made electronically, by 8:00 a.m. Eastern time on the business day after the
date first available, without charge, such reasonable number of copies of the
Prospectus or Prospectuses (including each form of prospectus) and each
amendment or supplement thereto as such Purchasers may reasonably request. The
Company hereby consents to the use of such Prospectus and each amendment or
supplement thereto by each of the selling Purchasers in connection with the
offering and sale of the Registrable Securities covered by such Prospectus and
any amendment or supplement thereto.

(e) In the event the Company’s Common Stock is then listed on the NASDAQ Stock
Market: (i) In the time and manner required by NASD, prepare and file with NASD
an additional shares listing application covering all of the Registrable
Securities and a notification form regarding the change in the number of the
Company’s outstanding Shares; (ii) use its best efforts, regardless of listing
or similar costs, to take all steps reasonably necessary to cause such
Registrable Securities to be approved for listing on The NASDAQ Stock Market as
soon as possible thereafter; (iii) provide to the Purchasers notice of such
listing; and (iv) use its best efforts, regardless of listing or similar costs,
to maintain the listing of such Registrable Securities on The NASDAQ Stock
Market.

(f) To the extent required by law, prior to any public offering of Registrable
Securities, use its best efforts to register or qualify or cooperate with the
selling Purchasers in connection with the registration or qualification (or
exemption from such registration or qualification) of such Registrable
Securities for offer and sale under the securities or “blue sky” laws of such
jurisdictions within the United States as any Purchaser requests in writing, to
keep each such registration or qualification (or exemption therefrom) effective
during the Effectiveness Period and to do any and all other acts or things
reasonably necessary or advisable to enable the disposition in such
jurisdictions of the Registrable Securities covered by a Registration Statement;
provided, however, that the Company shall not be required for any such purpose
to (i) qualify generally to do business as a foreign corporation in any
jurisdiction wherein it would not be otherwise required to qualify but for the
requirements of this Paragraph (3)(f), or (ii) subject itself to taxation.

(g) Upon the occurrence of any event described in Paragraph (3)(b)(vi) above, as
promptly as reasonably possible, prepare a supplement or amendment, including a
post-effective amendment, to the Registration Statement or a supplement to the
related Prospectus or any document incorporated or deemed to be incorporated
therein by reference, and file any other required document so that, as
thereafter delivered, neither the Registration Statement nor such Prospectus
will contain an untrue statement of a material fact or omit to state a material
fact required to be stated therein or necessary to make the statements therein,
in light of the circumstances

 

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under which they were made, not misleading; provided, however, that the Company
may suspend sales pursuant to the Registration Statement for a period of up to
forty-five (45) days (unless the holders of at least a majority of the
then-eligible Registrable Securities consisting of outstanding shares of Common
Stock consent in writing to a longer delay of up to an additional sixty
(60) days) no more than once in any twelve-month period if the Company furnishes
to the holders of the Registrable Securities a certificate signed by the
Company’s Chief Executive Officer stating that in the good faith judgment of the
Company’s Board of Directors, there is some material development relating to the
operations or condition (financial or other) of the Company that has not been
disclosed to the general public and as to which it is in the Company’s best
interests not to disclose such development, and the Company shall not disclose
such development to the Purchasers; provided further, however, that the Company
may not so suspend sales more than once in any calendar year without the written
consent of the holders of at least a majority of the then-eligible Registrable
Securities consisting of outstanding shares of Common Stock. Each violation of
the Company’s obligation not to suspend sales pursuant to the Registration
Statement longer than permitted pursuant to the proviso of this Paragraph 3(g)
shall be deemed an “Event” and for each such default, Purchaser shall be
entitled to the payment provisions set forth in Paragraph 2(d)(i).

(h) Comply with all applicable rules and regulations of the SEC and the NASD in
all material respects, including using its best efforts to cooperate with the
Placement Agent or other registered broker-dealer making any filing required by
NASD Rule 2710 to permit resales of the Registrable Securities by the Purchasers
through registered broker-dealers.

(4) Registration Expenses. The Company shall pay (or reimburse the Purchasers
for) all fees and expenses incident to the performance of or compliance with
this Agreement by the Company, including without limitation (a) all registration
and filing fees and expenses, including without limitation those related to
filings with the SEC, Nasdaq and in connection with applicable state securities
or “Blue Sky” laws, (b) printing expenses (including, without limitation,
expenses of printing certificates for Registrable Securities and of printing
copies of Prospectuses reasonably requested by the Purchasers), (c) messenger,
telephone and delivery expenses, (d) and fees and expenses of all other Persons
retained by the Company in connection with the consummation of the transactions
contemplated by this Agreement. Notwithstanding the foregoing, each Purchaser
shall pay any and all costs, fees, discounts or commissions attributable to the
sale of its respective Registrable Securities.

(5) Indemnification.

(a) Indemnification by the Company. In consideration of each Purchaser’s
execution and delivery of this Agreement and in addition to the Company’s other
obligations hereunder, the Company shall, notwithstanding any termination of
this Agreement, indemnify, defend, protect and hold harmless each Purchaser, its
officers and directors, partners, members, agents, brokers and employees of each
of them, each Person who controls any such Purchaser (within the meaning of
Section 15 of the Securities Act or Section 20 of the Exchange Act) and the
officers, directors, partners, members, agents and employees of each such
controlling Person, and each underwriter of Registrable Securities, to the
fullest extent permitted by applicable law, from and against any and all losses,
claims, damages, liabilities, settlement costs and expenses, including without
limitation costs of preparation and reasonable attorneys’ fees (collectively,
“Losses”), as incurred, arising out of or relating to (A) any untrue or alleged
untrue statement of a material fact

 

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contained in the Registration Statement, any Prospectus or form of prospectus or
in any amendment or supplement thereto, or arising out of or relating to any
omission or alleged omission of a material fact required to be stated therein or
necessary to make the statements therein (in the case of any Prospectus or form
of prospectus or supplement thereto, in light of the circumstances under which
they were made) not misleading, except to the extent, but only to the extent,
that (i) such untrue statements or omissions are based upon information
regarding such Purchaser furnished in writing to the Company by such Purchaser
expressly for use therein, or to the extent that such information related to
such Purchaser or such Purchaser’s proposed method of distribution of
Registrable Securities and was reviewed and expressly approved in writing by
such Purchaser expressly for use in the Registration Statement, such Prospectus
or such form of Prospectus or in any amendment or supplement thereto (which
shall, however, be deemed to include disclosure substantially in accordance with
the “Plan of Distribution” attached hereto), or (ii) in the case of an
occurrence of an event of the type specified in Paragraph (3)(b) above, the use
by such Purchaser of an outdated or defective Prospectus after the Company has
duly notified such Purchaser in writing that the Prospectus is outdated or
defective and prior to the receipt by such Purchaser of the Advice contemplated
in Paragraph (6) below; (B) any misrepresentation or breach of any
representation or warranty made by the Company in the Offering Documents;
(C) any breach of any covenant, agreement or obligation of the Company contained
in the Offering Documents; or (D) any cause of action, suit or claim brought or
made against such Indemnified Party (as hereinafter defined) by a third party
(including for these purposes a derivative action brought on behalf of the
Company) and arising out of or resulting from (i) the execution, delivery,
performance or enforcement of the Offering Documents, (ii) any transaction
financed or to be financed in whole or in part, directly or indirectly, with the
proceeds of the issuance of the Securities, or (iii) the status of such
Purchaser as an investor in the Company pursuant to the transactions
contemplated by the Offering Documents, other than any such cause of action,
suit or claim resulting from the fraud or willful misconduct of such Purchaser.
The Company shall notify the Purchasers promptly of the institution, threat or
assertion of any Proceeding of which the Company is aware in connection with the
transactions contemplated by this Agreement.

(b) Indemnification by Purchasers. Each Purchaser shall, severally and not
jointly, indemnify and hold harmless the Company, its directors, officers,
agents and employees, and each Person who controls the Company (within the
meaning of Section 15 of the Securities Act and Section 20 of the Exchange Act),
and the directors, officers, agents or employees of such controlling Persons, to
the fullest extent permitted by applicable law, from and against all Losses (as
determined by a court of competent jurisdiction in a final judgment not subject
to appeal or review) arising out of or based upon any untrue statement or
alleged untrue statement of a material fact contained in any Registration
Statement, any Prospectus, or any form of prospectus or in any amendment or
supplement thereto, or arising out of or based upon any omission of a material
fact required to be stated therein or necessary to make the statements therein
not misleading to the extent, but only to the extent, that such untrue statement
or omission is contained in any information furnished in writing by such
Purchaser to the Company specifically for inclusion in such Registration
Statement or Prospectus or to the extent that (i) such untrue statements or
omissions are based upon information regarding such Purchaser furnished in
writing to the Company by such Purchaser expressly for use therein, or to the
extent that such information related to such Purchaser or such Purchaser’s
proposed method of distribution of Registrable Securities and was reviewed and
expressly approved in writing by

 

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such Purchaser expressly for use in the Registration Statement, such Prospectus
or such form of Prospectus or in any amendment or supplement thereto (which
shall, however, be deemed to include disclosure substantially in accordance with
the “Plan of Distribution” attached hereto), or (ii) in the case of an
occurrence of an event of the type specified in Paragraph (3)(b) above, the use
by such Purchaser of an outdated or defective Prospectus after the Company has
notified such Purchaser in writing that the Prospectus is outdated or defective
and prior to the receipt by such Purchaser of the Advice contemplated in
Paragraph (6) below. In no event shall the liability of any selling Purchaser
hereunder be greater in amount than the dollar amount of the net proceeds
received by such Purchaser upon the sale of the Registrable Securities giving
rise to such indemnification obligation.

(c) Conduct of Indemnification Proceedings. If any Proceeding shall be brought
or asserted against any Person entitled to indemnity hereunder (an “Indemnified
Party”), such Indemnified Party shall promptly notify the Person from whom
indemnity is sought (the “Indemnifying Party”) in writing, and the Indemnifying
Party shall assume the defense thereof, including the employment of counsel
reasonably satisfactory to the Indemnified Party and the payment of all fees and
expenses incurred in connection with defense thereof, provided, that the failure
of any Indemnified Party to give such notice shall not relieve the Indemnifying
Party of its obligations or liabilities pursuant to this Agreement, except (and
only) to the extent that such failure shall have prejudiced the Indemnifying
Party. An Indemnified Party shall have the right to employ separate counsel in
any such Proceeding and to participate in the defense thereof, but the fees and
expenses of such counsel shall be at the expense of such Indemnified Party or
Parties unless: (i) the Indemnifying Party has agreed in writing to pay such
fees and expenses; or (ii) the Indemnifying Party shall have failed promptly to
assume the defense of such Proceeding and to employ counsel reasonably
satisfactory to such Indemnified Party in any such Proceeding; or (iii) the
named parties to any such Proceeding (including any impleaded parties) include
both such Indemnified Party and the Indemnifying Party, and such Indemnified
Party shall have been advised by counsel that a conflict of interest is likely
to exist if the same counsel were to represent such Indemnified Party and the
Indemnifying Party (in which case, if such Indemnified Party notifies the
Indemnifying Party in writing that it elects to employ separate counsel at the
expense of the Indemnifying Party, the Indemnifying Party shall not have the
right to assume the defense thereof and such counsel shall be at the expense of
the Indemnifying Party; provided, however, that in the event that the
Indemnifying Party shall be required to pay the fees and expenses of separate
counsel, the Indemnifying Party shall only be required to pay the fees and
expenses of one separate counsel for such Indemnified Party or Parties. The
Indemnifying Party shall not be liable for any settlement of any such Proceeding
affected without its written consent, which consent shall not be unreasonably
withheld. No Indemnifying Party shall, without the prior written consent of the
Indemnified Party, effect any settlement of any pending Proceeding in respect of
which any Indemnified Party is a party, unless such settlement includes an
unconditional release of such Indemnified Party from all liability on claims
that are the subject matter of such Proceeding. All fees and expenses of the
Indemnified Party (including reasonable fees and expenses to the extent incurred
in connection with investigating or preparing to defend such Proceeding in a
manner not inconsistent with this Section) shall be paid to the Indemnified
Party, as incurred, within ten trading days of written notice thereof to the
Indemnifying Party (regardless of whether it is ultimately determined that an
Indemnified Party is not entitled to indemnification hereunder; provided, that
the Indemnifying Party may require such Indemnified Party to undertake to
reimburse all such fees and expenses to the extent it is finally judicially
determined that such Indemnified Party is not entitled to indemnification
hereunder).

 

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(d) Contribution. If a claim for indemnification under Paragraph (5)(a) or
(b) is unavailable to an Indemnified Party (by reason of public policy or
otherwise), then each Indemnifying Party, in lieu of indemnifying such
Indemnified Party, shall contribute to the amount paid or payable by such
Indemnified Party as a result of such Losses, in such proportion as is
appropriate to reflect the relative fault of the Indemnifying Party and
Indemnified Party in connection with the actions, statements or omissions that
resulted in such Losses as well as any other relevant equitable considerations.
The relative fault of such Indemnifying Party and Indemnified Party shall be
determined by reference to, among other things, whether any action in question,
including any untrue or alleged untrue statement of a material fact or omission
or alleged omission of a material fact, has been taken or made by, or related to
information supplied by, such Indemnifying Party or Indemnified Party, and the
parties’ relative intent, knowledge, access to information and opportunity to
correct or prevent such action, statement or omission. The amount paid or
payable by a party as a result of any Losses shall be deemed to include, subject
to the limitations set forth in Paragraph (5)(c), any reasonable attorneys’ or
other reasonable fees or expenses incurred by such party in connection with any
Proceeding to the extent such party would have been indemnified for such fees or
expenses if the indemnification provided for in this Paragraph 5(d) was
available to such party in accordance with its terms.

The parties hereto agree that it would not be just and equitable if contribution
pursuant to this Paragraph (5)(d) were determined by pro rata allocation or by
any other method of allocation that does not take into account the equitable
considerations referred to in the immediately preceding paragraph.
Notwithstanding the provision of this Paragraph (5)(d), no Purchaser shall be
required to contribute, in the aggregate, any amount in excess of the amount by
which the proceeds actually received by such Purchaser from the sale of the
Registrable Securities subject to the Proceeding exceeds the amount of any
damages that such Purchaser has otherwise been required to pay by reason of such
untrue or alleged untrue statement or omission or alleged omission. No Person
guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of
the Securities Act) shall be entitled to contribution from any Person who was
not guilty of such fraudulent misrepresentation.

The indemnity and contribution agreements contained in this Section are in
addition to any liability that the Indemnifying Parties may have to the
Indemnified Parties and any cause of action or similar right of the Indemnified
Parties against the Indemnifying Parties or others.

(6) Dispositions. Each Purchaser agrees that it will comply with the prospectus
delivery requirements of the Securities Act as applicable to it in connection
with sales of Registrable Securities pursuant to the Registration Statement.
Each Purchaser further agrees that, upon receipt of a notice from the Company of
the occurrence of any event of the kind described in Paragraphs (3)(b), such
Purchaser will discontinue disposition of such Registrable Securities under the
Registration Statement until such Purchaser’s receipt of the copies of the
supplemented Prospectus and/or amended Registration Statement contemplated by
Paragraph (3)(g), or until it is advised in writing (the “Advice”) by the
Company that the use of the applicable Prospectus may be resumed, and, in either
case, has received copies of any additional or supplemental filings that are
incorporated or deemed to be incorporated by reference in such Prospectus or
Registration Statement. The Company may provide appropriate stop orders to
enforce the provisions of this paragraph.

 

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(7) Piggy-Back on Registrations. Neither the Company nor any of its security
holders (other than the Purchasers and the Placement Agent, with respect to the
shares of Common Stock issuable upon the exercise of the Placement Agent
Warrants, in such capacities pursuant hereto) may include securities of the
Company in the Registration Statement other than the Registrable Securities, and
the Company shall not after the date hereof enter into any agreement providing
any such right with respect to the Registration Statement to any of its security
holders.

(8) Piggy-Back Registrations. If at any time during the Effectiveness Period,
other than any suspension period referred to in Paragraph (3)(g) above, there is
not an effective Registration Statement covering all of the Registrable
Securities and the Company shall determine to prepare and file with the SEC a
registration statement relating to an offering for its own account or the
account of others under the Securities Act of any of its equity securities,
other than on Form S-4 or Form S-8 (each as promulgated under the Securities
Act) or their then equivalents relating to equity securities to be issued solely
in connection with any acquisition of any entity or business or equity
securities issuable in connection with stock option or other employee benefit
plans, then the Company shall send to each Purchaser written notice of such
determination and if, within fifteen (15) days after receipt of such notice, any
such Purchaser shall so request in writing, the Company shall use its best
efforts to include in such registration statement all or any part of such
Registrable Securities not already covered by an effective Registration
Statement such Purchaser requests to be registered.

(9) Rule 144. For a period of two years following the date hereof, the Company
agrees with each holder of Registrable Securities to:

(a) use its best efforts to comply with the requirements of Rule 144(c) under
the Securities Act with respect to current public information about the Company;

(b) use its best efforts to file with the SEC in a timely manner all reports and
other documents required of the Company under the Securities Act and the
Exchange Act (at any time it is subject to such reporting requirements); and

(c) furnish to any holder of Registrable Securities upon request (i) a written
statement by the Company as to its compliance with the requirements of said Rule
144(c) and the reporting requirements of the Securities Act and the Exchange Act
(at any time it is subject to such reporting requirements), (ii) a copy of the
most recent annual or quarterly report of the Company, and (iii) such other
reports and documents of the Company as such holder may reasonably request to
avail itself of any similar rule or regulation of the SEC allowing it to sell
any such securities without registration.

 

F. Covenants of the Company

(1) The Company hereby agrees that, for a period of sixty (60) days after
effectiveness of the first Registration Statement, it shall not issue or sell
any Common Stock of the Company, any warrants or other rights to acquire Common
Stock or any other

 

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securities that are convertible into Common Stock, with the exception of
issuances or sales related to a strategic transaction, pursuant to the exercise
of an option, warrant or other right to acquire Common Stock outstanding as of
the date of this Agreement, or to an employee, director, consultant, supplier,
lender or lessor, or any option grant or issuance.

(2) Until forty-five (45) days following effectiveness of the first Registration
Statement, the Company shall not cause any registration statement to become
effective, other than the Registration Statement contemplated hereby, any
registration statement on Form S-8 or other appropriate form related to
securities issued or to be issued pursuant to any option or other plan for the
benefit of the Company’s employees, officers, directors or consultants, or any
registration statement filed on Form S-4 relating to securities issued in
connection with a merger or other acquisition; provided, however, that nothing
herein shall prohibit the Company from maintaining the effectiveness of any
currently outstanding registration statement filed by the Company under the
Securities Act, including, without limitation, the filing of post-effective
amendments to such registration statements.

(3) The Company shall make a public announcement of the execution of this
Agreement and the terms of the transaction documents by issuing a press release
and filing with the SEC a Current Report on Form 8-K not later than 8:30 a.m.
Eastern time on the business day following the date this Agreement is entered
into. As a result of the forgoing issuance and filing, all material, non-public
information previously provided to the Purchasers or their agents or counsel
shall have been publicly announced and disclosed.

(4) The Company shall make a public announcement of the Closing of the Offering
by issuing a press release not later than 8:30 a.m. Eastern time on the business
day following the Closing, and thereafter the Company shall file with the SEC a
Current Report on Form 8-K within the time frame required by law.
Notwithstanding anything in this Agreement to the contrary, following the
foregoing issuance and filing the Company shall have no obligation to, and will
not, disclose or provide any material, non-public information to the Purchasers
or their agents or counsel.

(5) During the period any Securities issued pursuant to the Offering Documents
remain outstanding, the Company shall use its best efforts to ensure the
Company’s Common Stock is either quoted on the OTC Bulletin Board, or listed for
trading on a national securities exchange, in the sole discretion of the
Company. The Company and the Purchasers expressly agree that the quotation of
the Company’s Common Stock on the “pink sheets” shall not be considered to
satisfy the Company’s obligations pursuant to this covenant.

 

G. Miscellaneous

(1) All pronouns and any variations thereof used herein shall be deemed to refer
to the masculine, feminine, singular or plural, as identity of the person or
persons may require.

(2) Any notice or other document required or permitted to be given or delivered
to the Purchasers shall be in writing and sent (a) by fax if the sender on the
same day sends a confirming copy of such notice by an internationally recognized
overnight delivery service (charges prepaid) or (b) by an internationally
recognized overnight delivery service (with charges prepaid):

 

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  (i) if to the Company, at

 

Cardium Therapeutics, Inc.

3611 Valley Centre, Suite 525 San Diego, CA. 92130 Fax No.: 858-436-1011
Attention: Tyler M. Dylan, Chief Business Officer

or such other address as it shall have specified to the Purchaser in writing,
with a copy (which shall not constitute notice) to:

 

Fisher Thurber LLP

4225 Executive Square, Suite 1600

La Jolla, CA. 92037

Fax No.: 858-535-1616

Attention: David A. Fisher, Esq

(ii) if to the Purchaser, at its address set forth on the signature page to this
Agreement, or such other address as it shall have specified to the Company in
writing, with a copy (which shall not constitute notice and shall be for
informational purposes only) to:

 

Schulte Roth & Zabel LLP

919 Third Avenue

New York, New York 10022

Telephone No.: 212-756-2000

Fax No.: 212-593-5955

Attention: Eleazer N. Klein, Esq.

(3) Failure of the Company to exercise any right or remedy under this Agreement
or any other agreement between the Company and the Purchaser, or otherwise, or
delay by the Company in exercising such right or remedy, will not operate as a
waiver thereof. No waiver by the Company will be effective unless and until it
is in writing and signed by the Company.

(4) This Agreement shall be enforced, governed and construed in all respects in
accordance with the laws of the State of New York, as such laws are applied by
the New York courts to agreements entered into and to be performed in New York
by and between residents of New York, and shall be binding upon the Purchaser,
the Purchaser’s heirs, estate, legal representatives, successors and assigns and
shall inure to the benefit of the Company, its successors and assigns.

(5) If any provision of this Agreement is held to be invalid or unenforceable
under any applicable statute or rule of law, then such provision shall be deemed
modified to conform with such statute or rule of law. Any provision hereof that
may prove invalid or unenforceable under any law shall not affect the validity
or enforceability of any other provisions hereof.

 

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(6) The parties understand and agree that, unless provided otherwise herein,
money damages would not be a sufficient remedy for any breach of the Agreement
by the Company or the Purchaser and that the party against which such breach is
committed shall be entitled to equitable relief, including injunction and
specific performance, as a remedy for any such breach. Such remedies shall not,
unless provided otherwise herein, be deemed to be the exclusive remedies for a
breach by either party of the Agreement but shall be in addition to all other
remedies available at law or equity to the party against which such breach is
committed.

(7) The obligations of each Purchaser under this Agreement are several and not
joint with the obligations of any other Purchaser, and no Purchaser shall be
responsible in any way for the performance of the obligations of any other
Purchaser hereunder, except as may result from the actions of any such Purchaser
other than through the execution hereof. Nothing contained herein solely by
virtue of being contained herein shall be deemed to constitute the Purchasers as
a partnership, an association, a joint venture or any similar entity, or create
a presumption that the Purchasers are in any way acting in concert or as a group
with respect to such obligations or the transactions contemplated hereby.

(8) This Agreement, together with the agreements and documents executed and
delivered in connection with this Agreement, constitutes the entire agreement
between the parties hereto with respect to the subject matter hereof.

 

H. Signature

The signature page of this Agreement is contained as part of the applicable
subscription package, entitled “Signature Page”.

* * * * * * *

 

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SIGNATURE PAGE

The Purchaser hereby subscribes for such number of Shares as shall equal the
Subscription Amount as set forth below, divided by the Offering Price, and shall
also receive a Warrant to purchase such number of shares of Common Stock
calculated as set forth in this Agreement, and agrees to be bound by the terms
and conditions of this Agreement.

PURCHASER

 

1. Dated:                             , 2007

 

2. Total Subscription Amount: $                    

 

 

   

 

Signature of Subscriber     Signature of Joint Purchaser (and title, if
applicable)     (if any)

 

   

 

Taxpayer Identification or Social     Taxpayer Identification or Social Security
Number     Security Number of Joint Purchaser (if any)

 

    Name (please print as name will appearon stock certificate)    

 

    Number and Street    

 

    City, State   Zip Code     ACCEPTED BY:     CARDIUM THERAPEUTICS, Inc.    
By:  

 

    Name:       Title:       Dated:  

 

   

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Schedule A

Escrow Instructions

PLEASE SEND WIRE TRANSFERS TO THE ESCROW ACCOUNT AS FOLLOWS:

 

Bank:      The Bank of New York ABA No.:      021-000-018 Account No.:     
GLA/111565 Customer Account No.:      277284 Account Name:     
Oppenheimer / Cardium Therapeutics

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Exhibit A

Legal Matters

Fisher Thurber LLP shall deliver an opinion covering the following matters. The
opinion shall be subject to and include customary assumptions, limitations and
qualifications.

1. The Company is a corporation, validly existing and in good standing under the
laws of the State of Delaware and has all requisite corporate power and
authority under the laws of the State of Delaware to conduct its business as it
is described in the Company’s Form 10-QSB for the quarter ended September 30,
2006 and Form 10-KSB for the fiscal year ended December 31, 2005, and to enter
into and perform its obligations under the Agreement.

2. The authorized capital stock of the Company consists of 200,000,000 shares of
common stock, par value $0.0001 per share (the “Common Stock”), and 40,000,000
shares of preferred stock, par value $0.0001 per share (the “Preferred Stock”).

3. The Shares have been duly authorized or reserved for issuance by all
necessary corporate action on the part of the Company; and the Shares, when
issued and delivered against payment therefore in accordance with the provisions
of the Agreement, will be validly issued, fully paid and non-assessable. The
Warrants have been duly authorized by all necessary corporate action on the part
of the Company, and the Warrant Shares have been duly reserved for issuance and,
when issued and delivered against payment therefore upon the due exercise of the
Warrants in accordance with the provisions thereof, will be validly issued,
fully paid and non-assessable shares of Common Stock.

4. The execution and delivery by the Company of the Agreement, and the
consummation by the Company of the transactions contemplated thereby, have been
duly authorized by all necessary corporate action on the part of the Company.
The Agreement constitutes the valid and binding obligation of the Company,
enforceable against the Company in accordance with its terms, except as rights
to indemnification and contribution thereunder may be limited by applicable law
and except as the enforcement thereof may be limited by bankruptcy, insolvency,
reorganization, moratorium or other similar laws relating to or affecting
creditors’ rights generally or by general equitable principles.

5. The execution and delivery by the Company of the Agreement, and the
consummation by the Company of the transactions contemplated thereby, do not
(a) violate the provisions of any federal law of the United States of America or
the General Corporation Law of the State of Delaware applicable to the Company;
(b) violate the provisions of the Company’s Certificate of Incorporation or
By-laws; or (c) violate any existing obligation of the Company under any
judgment, decree, order or award of any court, governmental body or arbitrator
specifically naming the Company and of which we are aware, without any inquiry;
or (d) with or without notice and/or the passage of time, conflict with or
result in the material breach or termination of any material term or provision
of, or constitute a material default under, or cause any acceleration of any
material obligation under, or cause the creation of any material lien, charge or
encumbrance upon the material properties or assets of the Company pursuant to
any contract or instrument in the form included as an exhibit to the Company’s
2005 10-KSB and subsequent SEC Reports.

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6. Assuming (a) the accuracy of the representations made by each Purchaser in
the Agreement; (b) that neither the Company, the Placement Agent nor any person
acting on behalf of either the Company or the Placement Agent has offered or
sold the Securities by any form of general solicitation or general advertising
within the meaning of Rule 502(c) of Regulation D promulgated (the “Regulation
D”) under the Securities Act; (c) that no offerings or sales of securities of
the Company after the date hereof in a transaction can be “integrated” with any
sales of the Securities; and (d) that each person or entity that purchased
securities of the Company directly from the Company or its agents and without
registration between the date six months prior to the Closing of the Offering
and the date of the Agreement was, as of the date of such purchase, an
“accredited investor” as defined in Rule 501 of Regulation D, the sale of the
Securities to the Purchasers at the Closing under the circumstances contemplated
by this Agreement are exempt from the registration and prospectus delivery
requirements of Section 5 of the Securities Act.

7. To our knowledge, without any inquiry (including, without limitation, without
any docket search or other inquiry), there is no action, proceeding or
litigation pending or threatened against the Company before any court,
governmental or administrative agency or body required to be described in the
Company’s Form 10-QSB for each of the quarters ended September 30, 2006 and
June 30, 2006, and the Company’s Form 10-KSB for the fiscal year ended
December 31, 2005, which is not otherwise disclosed therein.

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Exhibit B

Form of Warrant

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THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUED UPON ITS

EXERCISE ARE SUBJECT TO THE RESTRICTIONS ON

TRANSFER SET FORTH IN SECTION 5 OF THIS WARRANT

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Warrant No. [    ]   Number of Shares: [        ]           (subject to
adjustment) Date of Issuance: [                    ], 2007   Original Issue Date
(as defined in subsection   2(a)): [                    ], 2007  

Cardium Therapeutics, Inc.

Common Stock Purchase Warrant

(Void after [                    ], 2012)

Cardium Therapeutics, Inc., a Delaware corporation (the “Company”), for value
received, hereby certifies that [                            ], or its
registered assigns (the “Registered Holder”), is entitled, subject to the terms
and conditions set forth below, to purchase from the Company, at any time or
from time to time on or after [the date hereof] and on or before 5:00 p.m.
(Eastern time) on [                    ], 2012 (the “Exercise Period”),
[        ] shares of Common Stock, $0.0001 par value per share, of the Company
(“Common Stock”), at a purchase price of $3.75 per share. The shares purchasable
upon exercise of this Warrant, and the purchase price per share, each as
adjusted from time to time pursuant to the provisions of this Warrant, are
hereinafter referred to as the “Warrant Shares” and the “Purchase Price,”
respectively. This Warrant is one of a series of Warrants issued by the Company
in connection with a private placement of Common Stock and of like tenor, except
as to the number of shares of Common Stock subject thereto (collectively, the
“Company Warrants”).

 

  1. Exercise.

(a) Exercise for Cash. The Registered Holder may, at its option, elect to
exercise this Warrant, in whole or in part and at any time or from time to time
during the Exercise Period, by surrendering this Warrant, with the purchase form
appended hereto as Exhibit I duly executed by or on behalf of the Registered
Holder, at the principal office of the Company, or at such other office or
agency as the Company may designate, accompanied by payment in full, in lawful
money of the United States, of the Purchase Price payable in respect of the
number of Warrant Shares purchased upon such exercise. A facsimile signature of
the Registered Holder on the purchase form shall be sufficient for purposes of
exercising this Warrant, provided that the Company receives the Registered
Holder’s original signature with three (3) business days thereafter.

(b) Cashless Exercise.

(i) At any time during the Exercise Period when the resale of the Warrant Shares
by the Registered Holder is not registered pursuant to an effective registration
statement filed with the Securities and Exchange Commission under the Securities
Act of 1933, as amended (the “Securities Act”), the Registered Holder may, at
its option, elect to exercise this Warrant, in whole or in part, on a

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elect to exercise this Warrant, in whole or in part, on a cashless basis, by
surrendering this Warrant, with the purchase form appended hereto as Exhibit I
duly executed by or on behalf of the Registered Holder, at the principal office
of the Company, or at such other office or agency as the Company may designate,
by canceling a portion of this Warrant in payment of the Purchase Price payable
in respect of the number of Warrant Shares purchased upon such exercise. In the
event of an exercise pursuant to this subsection 1(b), the number of Warrant
Shares issued to the Registered Holder shall be determined according to the
following formula:

X = Y(A-B)

A

 

Where:    X =    the number of Warrant Shares that shall be issued to the
Registered Holder;    Y =    the number of Warrant Shares for which this Warrant
is being exercised (which shall include both the number of Warrant Shares issued
to the Registered Holder and the number of Warrant Shares subject to the portion
of the Warrant being cancelled in payment of the Purchase Price);    A =    the
Fair Market Value (as defined below) of one share of Common Stock; and    B =   
the Purchase Price then in effect.

(ii) “Fair Market Value” means, for any security as of any date, the closing
sale price for such security on the Nasdaq OTC Bulletin Board, as reported by
Bloomberg, or, if the Nasdaq OTC Bulletin Board begins to operate on an extended
hours basis and does not designate the closing sale price then the last sale
price of such security prior to 4:00:00 p.m., New York time, as reported by
Bloomberg, or, if the Nadaq OTC Bulletin Board is not the principal securities
exchange or trading market for such security, the last sale price of such
security on the principal securities exchange or trading market where such
security is listed or traded as reported by Bloomberg, or if the foregoing do
not apply, the last sale price of such security in an over-the-counter market on
the electronic bulletin board for such security as reported by Bloomberg, or, if
no last sale price is reported for such security by Bloomberg, the average of
the ask prices of any market makers for such security as reported in the “pink
sheets” by Pink Sheets LLC (formerly the National Quotation Bureau, Inc.). If
the Fair Market Value cannot be calculated for a security on a particular date
on any of the foregoing bases, the Fair Market Value of such security on such
date shall be the fair market value as mutually determined by the Company and
the Registered Holder. If the Company and the Registered Holder are unable to
agree upon the Fair Market Value of such security, then such dispute shall be
resolved pursuant to Section 13. All such determinations shall be appropriately
adjusted for any stock dividend, stock split, stock combination or other similar
transaction during the applicable calculation period.

 

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(c) Exercise Date. Each exercise of this Warrant shall be deemed to have been
effected immediately prior to the close of business on the day on which this
Warrant shall have been surrendered to the Company as provided in subsection
1(a) or 1(b) above (the “Exercise Date”). At such time, the person or persons in
whose name or names any certificates for Warrant Shares shall be issuable upon
such exercise as provided in subsection 1(d) below shall be deemed to have
become the holder or holders of record of the Warrant Shares represented by such
certificates.

(d) Issuance of Certificates. As soon as practicable after the exercise of this
Warrant in whole or in part, and in any event within three trading days
thereafter, the Company, at its expense, will cause to be issued in the name of,
and delivered to, the Registered Holder, or as the Registered Holder (upon
payment by the Registered Holder of any applicable transfer taxes) may direct:

(i) a certificate or certificates for the number of full Warrant Shares to which
the Registered Holder shall be entitled upon such exercise plus, in lieu of any
fractional share to which the Registered Holder would otherwise be entitled,
cash in an amount determined pursuant to Section 3 hereof; provided that in the
event the Company’s transfer agent is participating in The Depository Trust
Company (“DTC”) Fast Automated Securities Transfer Program, upon the request of
the Registered Holder in connection with the Registered Holder’s sale of such
Warrant Shares pursuant to an effective registration statement under the
Securities Act or an exemption from the registration requirements of the
Securities Act, the Company shall credit such aggregate number of shares of
Common Stock to which the Registered Holder is entitled pursuant to such
exercise to the Registered Holder’s or its designee’s balance account with DTC
through its Deposit Withdrawal Agent Commission system; and

(ii) in case such exercise is in part only, a new warrant or warrants (dated the
date hereof) of like tenor, calling in the aggregate on the face or faces
thereof for the number of Warrant Shares equal (without giving effect to any
adjustment therein) to the number of such shares called for on the face of this
Warrant minus the number of Warrant Shares for which this Warrant was so
exercised (which, in the case of an exercise pursuant to subsection 1(b), shall
include both the number of Warrant Shares issued to the Registered Holder
pursuant to such partial exercise and the number of Warrant Shares subject to
the portion of the Warrant being cancelled in payment of the Purchase Price).

If the Company shall fail to deliver or cause to be delivered for any reason or
no reason the shares of Common Stock as provided for above (the “Delivery
Deadline”), then, in addition to all other remedies available to the Registered
Holder, if on or after the trading day immediately following the Delivery
Deadline the Registered Holder purchases (in an open market transaction or
otherwise) shares of Common Stock to deliver in satisfaction of a sale by the
Registered Holder of shares of Common Stock that were to be represented by the
shares of Common Stock to be issued as provided for above (a “Buy-In”), then,
provided as of such purchase date the Registered Holder had not received such
shares of Common Stock, the Company shall, within three (3) business days after
written request by the Registered Holder and in the Registered Holder’s
discretion, either (i) pay cash to the Registered Holder in an amount equal to
the purchase price (including brokerage commissions, if any) paid by the
Registered Holder for the shares of Common Stock so purchased (the “Buy-In
Price”), at which point the Company’s obligation to issue such shares of Common
Stock shall terminate, or (ii) promptly honor its obligation to deliver to the
Registered Holder a certificate or certificates representing such

 

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shares of Common Stock and pay cash to the Registered Holder in an amount equal
to the excess (if any) of the Buy-In Price over the product of (A) such number
of shares of Common Stock, times (B) the Fair Market Value on the Delivery
Deadline.

[The following provision shall be included in this Warrant at the request of the
Registered Holder: (e) Beneficial Ownership. The Company shall not effect the
exercise of this Warrant, and the Registered Holder shall not have the right to
exercise this Warrant, to the extent that after giving effect to such exercise,
the Registered Holder (together with the Registered Holder’s affiliates) would
beneficially own in excess of 4.99% (the “Maximum Percentage”) of the shares of
Common Stock outstanding immediately after giving effect to such exercise. For
purposes of the foregoing sentence, the aggregate number of shares of Common
Stock beneficially owned by the Registered Holder and its affiliates shall
include the number of shares of Common Stock issuable upon exercise of this
Warrant with respect to which the determination of such sentence is being made,
but shall exclude shares of Common Stock which would be issuable upon
(i) exercise of the remaining, unexercised portion of this Warrant beneficially
owned by the Registered Holder and its affiliates and (ii) exercise or
conversion of the unexercised or unconverted portion of any other securities of
the Company beneficially owned by the Registered Holder and its affiliates
(including, without limitation, any convertible notes or convertible preferred
stock or warrants) subject to a limitation on conversion or exercise analogous
to the limitation contained herein. Except as set forth in the preceding
sentence, for purposes of this paragraph, beneficial ownership shall be
calculated in accordance with Section 13(d) of the Securities Exchange Act of
1934, as amended. For purposes of this Warrant, in determining the number of
outstanding shares of Common Stock, the Registered Holder may rely on the number
of outstanding shares of Common Stock as reflected in (1) the Company’s most
recent Form 10-K, Form 10-Q, Current Report on Form 8-K or other public filing
with the Securities and Exchange Commission, as the case may be, (2) a more
recent public announcement by the Company or (3) any other notice by the Company
or the Company’s transfer agent setting forth the number of shares of Common
Stock outstanding. For any reason at any time, upon the written or oral request
of the Registered Holder, the Company shall within one business day confirm
orally and in writing to the Registered Holder the number of shares of Common
Stock then outstanding. In any case, the number of outstanding shares of Common
Stock shall be determined after giving effect to the conversion or exercise of
securities of the Company, including the Company Warrants, by the Registered
Holder and its affiliates since the date as of which such number of outstanding
shares of Common Stock was reported. By written notice to the Company, the
Registered Holder may from time to time increase or decrease the Maximum
Percentage to any other percentage not in excess of 9.99% specified in such
notice; provided that (i) any such increase will not be effective until the
sixty-first (61st) day after such notice is delivered to the Company, and
(ii) any such increase or decrease will apply only to the Registered Holder and
not to any other holder of SPA Warrants.]

2. Adjustments.

(a) Adjustment for Stock Splits and Combinations. If the Company shall at any
time or from time to time after the date on which this Warrant was first issued
(or, if this Warrant was issued upon partial exercise of, or in replacement of,
another warrant of like tenor, then the date on which such original warrant was
first issued) (the “Original Issue Date”) effect a subdivision of the

 

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outstanding Common Stock, the Purchase Price then in effect immediately before
that subdivision shall be proportionately decreased. If the Company shall at any
time or from time to time after the Original Issue Date combine the outstanding
shares of Common Stock, the Purchase Price then in effect immediately before the
combination shall be proportionately increased. Any adjustment under this
paragraph shall become effective at the close of business on the date the
subdivision or combination becomes effective.

(b) Adjustment for Certain Dividends and Distributions. In the event the Company
at any time, or from time to time after the Original Issue Date shall make or
issue, or fix a record date for the determination of holders of Common Stock
entitled to receive, a dividend or other distribution payable in additional
shares of Common Stock, then and in each such event the Purchase Price then in
effect immediately before such event shall be decreased as of the time of such
issuance or, in the event such a record date shall have been fixed, as of the
close of business on such record date, by multiplying the Purchase Price then in
effect by a fraction:

(1) the numerator of which shall be the total number of shares of Common Stock
issued and outstanding immediately prior to the time of such issuance or the
close of business on such record date, and

(2) the denominator of which shall be the total number of shares of Common Stock
issued and outstanding immediately prior to the time of such issuance or the
close of business on such record date plus the number of shares of Common Stock
issuable in payment of such dividend or distribution; provided, however, that if
such record date shall have been fixed and such dividend is not fully paid or if
such distribution is not fully made on the date fixed therefore, the Purchase
Price shall be recomputed accordingly as of the close of business on such record
date and thereafter the Purchase Price shall be adjusted pursuant to this
paragraph as of the time of actual payment of such dividends or distributions.

(c) Adjustments for Other Dividends and Distributions. In the event the Company
at any time or from time to time after the Original Issue Date shall make or
issue, or fix a record date for the determination of holders of Common Stock
entitled to receive, a dividend or other distribution payable in securities of
the Company (other than shares of Common Stock) or in cash or other property
(other than regular cash dividends paid out of earnings or earned surplus,
determined in accordance with generally accepted accounting principles), then
and in each such event provision shall be made so that the Registered Holder
shall receive upon exercise hereof, in addition to the number of shares of
Common Stock issuable hereunder, the kind and amount of securities of the
Company, cash or other property which the Registered Holder would have been
entitled to receive had this Warrant been exercised on the date of such event
and had the Registered Holder thereafter, during the period from the date of
such event to and including the Exercise Date, retained any such securities
receivable during such period, giving application to all adjustments called for
during such period under this Section 2 with respect to the rights of the
Registered Holder.

 

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(d) Adjustment for Reorganization.

(i) If there shall occur any reorganization, recapitalization, reclassification,
consolidation or merger involving the Company in which the Common Stock is
converted into or exchanged for securities, cash or other property
(collectively, a “Reorganization”), then, following such Reorganization, the
Registered Holder shall receive upon exercise hereof the kind and amount of
securities, cash or other property which the Registered Holder would have been
entitled to receive pursuant to such Reorganization if such exercise had taken
place immediately prior to such Reorganization. Notwithstanding the foregoing
sentence, if (x) there shall occur any Reorganization in which the Common Stock
is converted into or exchanged for anything other than solely equity securities,
and (y) the common stock of the acquiring or surviving company is publicly
traded, then, as part of such Reorganization, (i) the Registered Holder shall
have the right thereafter to receive upon the exercise hereof such number of
shares of common stock of the acquiring or surviving company as is determined by
multiplying (A) the number of shares of Common Stock subject to this Warrant
immediately prior to such Reorganization by (B) a fraction, the numerator of
which is the Fair Market Value (as defined in subsection 1(b)(ii) above) per
share of Common Stock as of the effective date of such Reorganization, and the
denominator of which is the fair market value per share of common stock of the
acquiring or surviving company as of the effective date of such transaction, as
determined in good faith by the Board (using the principles set forth in
subsections 2(d)(i) and 2(d)(ii) to the extent applicable), and (ii) the
exercise price per share of common stock of the acquiring or surviving company
shall be the Purchase Price divided by the fraction referred to in clause (B)
above. In any such case, appropriate adjustment (as determined in good faith by
the Board) shall be made in the application of the provisions set forth herein
with respect to the rights and interests thereafter of the Registered Holder, to
the end that the provisions set forth in this Section 2 (including provisions
with respect to changes in and other adjustments of the Purchase Price) shall
thereafter be applicable, as nearly as reasonably may be, in relation to any
securities, cash or other property thereafter deliverable upon the exercise of
this Warrant.

(ii) Notwithstanding the foregoing, in the event of a Reorganization, if the
Registered Holder has not exercised the Warrant in full prior to the
consummation of the Reorganization, then the Registered Holder shall have the
right to require such acquiring or surviving company to purchase this Warrant
from the Registered Holder by paying to the Registered Holder, simultaneously
with the consummation of the Reorganization and in lieu of the warrant referred
to in Section 2(d), cash in an amount equal to the value of the remaining
unexercised portion of this Warrant on the date of such consummation, which
value shall be determined by use of the Black and Scholes Option Pricing Model
reflecting (i) a risk-free interest rate corresponding to the U.S. Treasury rate
for a period equal to the remaining term of this Warrant as of such date of
request and (ii) an expected volatility equal to the greater of 60% and the 100
day volatility obtained from the HVT function on Bloomberg.

(e) Adjustment for Certain Subsequent Offerings.

(i) In the event the Company, at any time after the Original Issue Date, shall
issue shares of Additional Stock (as defined below) for consideration per share
less than the Purchase Price in effect immediately prior to such issuance, then
the Purchase Price in effect immediately prior to such issuance shall be
adjusted to a Purchase Price equal to the Effective Price (as defined in
Subsection (ii) below).

 

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(ii) As used in this Section 2(e), “Additional Stock” shall mean any shares of
Common Stock issued by the Company or deemed to be issued pursuant to this
Section 2(e) after the Original Issue Date, except shares of Common Stock issued
(A) by reason of a stock split, combination, dividend, or other distribution or
issuance of shares of Common Stock that is covered by Sections 2(a), 2(b), 2(c)
or 2(d); (B) to employees or directors of, or consultants or advisors to, the
Company or any of its subsidiaries pursuant to a plan, agreement or arrangement
approved by the Board of Directors of the Company; (C) upon exercise of the
Company Warrants or any other warrants issued by the Company and outstanding as
of the Original Issue Date; (D) to banks, equipment lessors or other financial
institutions in connection with loans made to the Company; (E) to suppliers or
third party service providers in connection with the provision of goods or
services (the primary purpose of which is not to raise equity capital); or
(F) in connection with sponsored research, collaborations, technology license,
development, marketing or other similar agreements or strategic partnerships
(the primary purpose of which is not to raise equity capital). The “Effective
Price” of the shares of Additional Stock shall mean the quotient determined by
dividing the total number of shares of Additional Stock issued or sold, or
deemed to have been issued or sold by the Company under this Section 2(e), into
the aggregate consideration received, or deemed to have been received by the
Company for such issue under this Section 2(e), for such shares of Additional
Stock.

(iii) For the purpose of the adjustment required under this Section 2(e), if the
Company issues or sells (i) stock or other securities convertible into, shares
of Additional Stock (such convertible stock or securities being herein referred
to as “Convertible Securities”) or (ii) rights or options for the purchase of
shares of Additional Stock or Convertible Securities and if the Effective Price
of such shares of Additional Stock is less than the Purchase Price in each case
the Company shall be deemed to have issued at the time of the issuance of such
rights or options or Convertible Securities the maximum number of shares of
Additional Stock issuable upon exercise or conversion thereof and to have
received as consideration for the issuance of such shares an amount equal to the
total amount of the consideration, if any, received by the Company for the
issuance of such rights or options or Convertible Securities, plus, in the case
of such rights or options, the minimum amounts of consideration, if any, payable
to the Company upon the exercise of such rights or options, plus, in the case of
Convertible Securities, the minimum amounts of consideration, if any, payable to
the Company (other than by cancellation of liabilities or obligations evidenced
by such Convertible Securities) upon the conversion thereof; provided that if in
the case of Convertible Securities the minimum amounts of such consideration
cannot be ascertained, but are a function of antidilution or similar protective
clauses, the Company shall be deemed to have received the minimum amounts of
consideration without reference to such clauses; provided further that if the
minimum amount of consideration payable to the Company upon the exercise or
conversion of rights, options or Convertible Securities is reduced over time or
on the occurrence or non-occurrence of specified events other than by reason of
antidilution adjustments, the Effective Price shall be recalculated using the
figure to which such minimum amount of consideration is reduced; provided
further that if the minimum amount of consideration payable to the Company upon
the exercise or conversion of such rights, options or Convertible Securities is
subsequently increased, the Effective Price shall be again recalculated using
the increased minimum amount of consideration payable to the Company upon the
exercise or conversion of such rights, options or Convertible Securities. No
further adjustment of the Purchase Price, as adjusted upon the issuance of such
rights, options or Convertible Securities, shall be made as a result of the
actual issuance of shares of Additional Stock on the exercise of any such rights
or options or the conversion of any

 

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such Convertible Securities. If any such rights or options or the conversion
privilege represented by any such Convertible Securities shall expire without
having been exercised, the Purchase Price as adjusted upon the issuance of such
rights, options or Convertible Securities shall be readjusted to the Purchase
Price which would have been in effect had an adjustment been made on the basis
that the only shares of Additional Stock so issued were the shares of Additional
Stock, if any, actually issued or sold on the exercise of such rights or options
or rights of conversion of such Convertible Securities, and such shares of
Additional Stock, if any, were issued or sold for the consideration actually
received by the Company upon such exercise, plus the consideration, if any,
actually received by the Company for the granting of all such rights or options,
whether or not exercised, plus the consideration received for issuing or selling
the Convertible Securities, whether or not converted, plus the consideration, if
any, actually received by the Company (other than by cancellation of liabilities
or obligations evidenced by such Convertible Securities) on the conversion of
such Convertible Securities.

(f) Certificate as to Adjustments. Upon the occurrence of each adjustment or
readjustment of the Purchase Price pursuant to this Section 2, the Company at
its expense shall, as promptly as reasonably practicable but in any event not
later than 10 days thereafter, compute such adjustment or readjustment in
accordance with the terms hereof and furnish to the Registered Holder a
certificate setting forth such adjustment or readjustment (including the kind
and amount of securities, cash or other property for which this Warrant shall be
exercisable and the Purchase Price) and showing in detail the facts upon which
such adjustment or readjustment is based. The Company shall, as promptly as
reasonably practicable after the written request at any time of the Registered
Holder (but in any event not later than 10 days thereafter), furnish or cause to
be furnished to the Registered Holder a certificate setting forth (i) the
Purchase Price then in effect and (ii) the number of shares of Common Stock and
the amount, if any, of other securities, cash or property which then would be
received upon the exercise of this Warrant.

3. Fractional Shares. The Company shall not be required upon the exercise of
this Warrant to issue any fractional shares, but shall pay the value thereof to
the Registered Holder in cash on the basis of the Fair Market Value per share of
Common Stock, as determined pursuant to subsection 2(d) above.

4. Call Provision. Notwithstanding any other provision contained herein to the
contrary, at any time after [            ], 2008, in the event that the closing
price of the Common Stock as reported on OTCBB (or such other exchange or stock
market on which the Common Stock may then be listed or quoted) is at least $7.50
(appropriately adjusted for any stock split, reverse stock split, stock dividend
or other reclassification or combination of the Common Stock occurring after the
date hereof) for twenty (20) consecutive trading days (the “Trading Period”),
provided, that the actual average daily trading volume of the Common Stock for
the Trading Period is greater than 200,000 shares per day, upon thirty (30) days
prior written notice (the “Notice Period”) to the Registered Holder, the Company
may repurchase this Warrant in full. In order for the Company to repurchase this
Warrant, (i) the Company must give a similar notice to all holders of the
Company Warrants and repurchase all Company Warrants, and (ii) the Warrant
Shares must (A) have been registered pursuant to an effective Registration
Statement which has not been suspended and for which no stop order is in effect,
and pursuant to which the Registered Holder is able to sell such Warrant Shares
at all times during the Notice Period or (B) no longer constitute Registrable
Securities (as defined in the Securities Purchase Agreement of even date
herewith, by and

 

- 8 -

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between the Company and the Purchasers noted therein). Notwithstanding any such
notice by the Company, the Registered Holder shall have the right to exercise
this Warrant prior to the end of the Notice Period. Upon exercise of the
Company’s repurchase right set forth herein, the Company shall pay the
Registered Holder an aggregate amount equal to $0.01 per Warrant Share.

5. Transfers, etc.

(a) Notwithstanding anything to the contrary contained herein, this Warrant and
the Warrant Shares shall not be sold or transferred unless either (i) they first
shall have been registered under the Securities Act of 1933, as amended (the
“Act”), or (ii) such sale or transfer shall be exempt from the registration
requirements of the Act and the Company shall have been furnished with an
opinion of legal counsel, reasonably satisfactory to the Company, to the effect
that such sale or transfer is exempt from the registration requirements of the
Act. Notwithstanding the foregoing, no registration or opinion of counsel shall
be required for (i) a transfer by a Registered Holder which is an entity to a
wholly owned subsidiary or affiliate of such entity, a transfer by a Registered
Holder which is a partnership to a partner of such partnership or a retired
partner of such partnership or to the estate of any such partner or retired
partner, or a transfer by a Registered Holder which is a limited liability
company to a member of such limited liability company or a retired member or to
the estate of any such member or retired member, provided that the transferee in
each case agrees in writing to be subject to the terms of this Section 5, or
(ii) a transfer made in accordance with Rule 144 under the Act.

(b) Each certificate representing Warrant Shares shall bear a legend
substantially in the following form:

“The securities represented hereby have not been registered under the Securities
Act of 1933, as amended, or any state securities laws and neither the securities
nor any interest therein may be offered, sold, transferred, pledged or otherwise
disposed of except pursuant to an effective registration under such act or an
exemption from registration, which, in the opinion of counsel reasonably
satisfactory to counsel for this corporation, is available.”

The foregoing legend shall be removed from the certificates representing any
Warrant Shares, at the request of the holder thereof, at such time as they
become eligible for resale pursuant to Rule 144(k) under the Act or at such time
as the Warrant Shares are sold or transferred in accordance with the
requirements of a registration statement of the Company on Form S-1, or such
other form as may then be in effect.

(c) The Company will maintain a register containing the name and address of the
Registered Holder of this Warrant. The Registered Holder may change its address
as shown on the warrant register by written notice to the Company requesting
such change.

(d) Subject to the provisions of Section 5 hereof, this Warrant and all rights
hereunder are transferable, in whole or in part, upon surrender of this Warrant
with a properly executed assignment (in the form of Exhibit II hereto) at the
principal office of the Company (or, if another office or agency has been
designated by the Company for such purpose, then at such other office or
agency).

 

- 9 -

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6. No Impairment. The Company will not, by amendment of its charter or through
any reorganization, transfer of assets, consolidation, merger, dissolution,
issue or sale of securities or any other voluntary action, avoid or seek to
avoid the observance or performance of any of the terms of this Warrant, but
will at all times in good faith assist in the carrying out of all such terms and
in the taking of all such action as may be necessary or appropriate in order to
protect the rights of the Registered Holder against impairment.

7. Notices of Record Date, etc. In the event:

(a) the Company shall take a record of the holders of its Common Stock (or other
stock or securities at the time deliverable upon the exercise of this Warrant)
for the purpose of entitling or enabling them to receive any dividend or other
distribution, or to receive any right to subscribe for or purchase any shares of
stock of any class or any other securities, or to receive any other right; or

(b) of any capital reorganization of the Company, any reclassification of the
Common Stock of the Company, any consolidation or merger of the Company with or
into another corporation, or any transfer of all or substantially all of the
assets of the Company; or

(c) of the voluntary or involuntary dissolution, liquidation or winding-up of
the Company, then, and in each such case, the Company will send or cause to be
sent to the Registered Holder a notice specifying, as the case may be, (i) the
record date for such dividend, distribution or right, and the amount and
character of such dividend, distribution or right, or (ii) the effective date on
which such reorganization, reclassification, consolidation, merger, transfer,
dissolution, liquidation or winding-up is to take place, and the time, if any is
to be fixed, as of which the holders of record of Common Stock (or such other
stock or securities at the time deliverable upon the exercise of this Warrant)
shall be entitled to exchange their shares of Common Stock (or such other stock
or securities) for securities or other property deliverable upon such
reorganization, reclassification, consolidation, merger, transfer, dissolution,
liquidation or winding-up. Such notice shall be sent at least 10 days prior to
the record date or effective date for the event specified in such notice.

8. Reservation of Stock. The Company will at all times reserve and keep
available, solely for issuance and delivery upon the exercise of this Warrant,
such number of Warrant Shares and other securities, cash and/or property, as
from time to time shall be issuable upon the exercise of this Warrant.

9. Exchange or Replacement of Warrants.

(a) Upon the surrender by the Registered Holder, properly endorsed, to the
Company at the principal office of the Company, the Company will, subject to the
provisions of Section 5 hereof, issue and deliver to or upon the order of the
Registered Holder, at the Company’s expense, a new Warrant or Warrants of like
tenor, in the name of the Registered Holder or as the Registered Holder (upon
payment by the Registered Holder of any applicable transfer taxes) may direct,
calling in the aggregate on the face or faces thereof for the number of shares
of Common Stock (or other securities, cash and/or property) then issuable upon
exercise of this Warrant.

 

- 10 -

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(b) Upon receipt of evidence reasonably satisfactory to the Company of the loss,
theft, destruction or mutilation of this Warrant and (in the case of loss, theft
or destruction) upon delivery of an indemnity agreement (with surety if
reasonably required) in an amount reasonably satisfactory to the Company, or (in
the case of mutilation) upon surrender and cancellation of this Warrant, the
Company will issue, in lieu thereof, a new Warrant of like tenor.

10. Notices. All notices and other communications from the Company to the
Registered Holder in connection herewith shall be mailed by certified or
registered mail, postage prepaid, or sent via a reputable nationwide overnight
courier service guaranteeing next business day delivery, to the address last
furnished to the Company in writing by the Registered Holder. All notices and
other communications from the Registered Holder to the Company in connection
herewith shall be mailed by certified or registered mail, postage prepaid, or
sent via a reputable nationwide overnight courier service guaranteeing next
business day delivery, to the Company at its principal office set forth below.
If the Company should at any time change the location of its principal office to
a place other than as set forth below, it shall give prompt written notice to
the Registered Holder and thereafter all references in this Warrant to the
location of its principal office at the particular time shall be as so specified
in such notice. All such notices and communications shall be deemed delivered
one business day after being sent via a reputable international overnight
courier service guaranteeing next business day delivery.

11. No Rights as Stockholder. Until the exercise of this Warrant, the Registered
Holder shall not have or exercise any rights by virtue hereof as a stockholder
of the Company. Notwithstanding the foregoing, in the event (i) the Company
effects a split of the Common Stock by means of a stock dividend and the
Purchase Price of and the number of Warrant Shares are adjusted as of the date
of the distribution of the dividend (rather than as of the record date for such
dividend), and (ii) the Registered Holder exercises this Warrant between the
record date and the distribution date for such stock dividend, the Registered
Holder shall be entitled to receive, on the distribution date, the stock
dividend with respect to the shares of Common Stock acquired upon such exercise,
notwithstanding the fact that such shares were not outstanding as of the close
of business on the record date for such stock dividend.

12. Amendment or Waiver. Any term of this Warrant may be amended or waived
(either generally or in a particular instance and either retroactively or
prospectively) with the written consent of the Company and the holders of
Company Warrants representing at least two-thirds of the number of shares of
Common Stock then subject to outstanding Company Warrants. Notwithstanding the
foregoing, (a) this Warrant may be amended and the observance of any term
hereunder may be waived without the written consent of the Registered Holder
only in a manner which applies to all Company Warrants in the same fashion and
(b) the number of Warrant Shares subject to this Warrant and the Purchase Price
of this Warrant may not be amended, and the right to exercise this Warrant may
not be waived, without the written consent of the Registered Holder (it being
agreed that an amendment to or waiver under any of the provisions of Section 2
of this Warrant shall not be considered an amendment of the number of Warrant
Shares or the Purchase Price). The Company shall give prompt written notice to
the Registered Holder of any amendment hereof or waiver hereunder

 

- 11 -

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that was effected without the Registered Holder’s written consent. No waivers of
any term, condition or provision of this Warrant, in any one or more instances,
shall be deemed to be, or construed as, a further or continuing waiver of any
such term, condition or provision.

13. Dispute Resolution. In the case of a dispute as to the determination of the
Purchase Price or the arithmetic calculation of the Warrant Shares, the Company
shall submit the disputed determinations or arithmetic calculations via
facsimile within two business days of receipt of the Purchase Form giving rise
to such dispute, as the case may be, to the Registered Holder. If the Holder and
the Company are unable to agree upon such determination or calculation of the
Purchase Price or the Warrant Shares within three business days of such disputed
determination or arithmetic calculation being submitted to the Registered
Holder, then the Company shall, within two business days submit via facsimile
(a) the disputed determination of the Purchase Price to an independent,
reputable investment bank selected by the Company and approved by the Holder or
(b) the disputed arithmetic calculation of the Warrant Shares to the Company’s
independent, outside accountant. The Company, at the Company’s expense, shall
use reasonable best efforts to cause at its expense the investment bank or the
accountant, as the case may be, to perform the determinations or calculations
and notify the Company and the Registered Holder of the results no later than
ten business days from the time it receives the disputed determinations or
calculations. Such investment bank’s or accountant’s determination or
calculation, as the case may be, shall be binding upon all parties absent
demonstrable error.

14. Section Headings. The section headings in this Warrant are for the
convenience of the parties and in no way alter, modify, amend, limit or restrict
the contractual obligations of the parties.

15. Governing Law. This Warrant will be governed by and construed in accordance
with the internal laws of the State of New York (without reference to the
conflicts of law provisions thereof).

16. Facsimile Signatures. This Warrant may be executed by facsimile signature.

* * * * * * *

 

- 12 -

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EXECUTED as of the Date of Issuance indicated above.

 

CARDIUM THERAPEUTICS, INC. By:  

 

Name:   Title:  

 

ATTEST:

 

 

- 13 -

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EXHIBIT I

PURCHASE FORM

To: Cardium Therapeutics, Inc.                                        
                                              Dated:                            

The undersigned, pursuant to the provisions set forth in the attached Warrant
(No.         ), hereby elects to purchase (check applicable box):

q      shares of the Common Stock of Cardium Therapeutics, Inc. covered by such
Warrant; or

q      the maximum number of shares of Common Stock covered by such Warrant
pursuant to the cashless exercise procedure set forth in subsection 1(b).

The undersigned herewith makes payment of the full purchase price for such
shares at the price per share provided for in such Warrant. Such payment takes
the form of (check applicable box or boxes):

 

  q  

$             in lawful money of the United States; and/or

 

  q  

the cancellation of such portion of the attached Warrant as is exercisable for a
total of          Warrant Shares (using a Fair Market Value determined in
accordance with Section 1(b)(ii)) ; and/or

 

  q  

the cancellation of such number of Warrant Shares as is necessary, in accordance
with the formula set forth in subsection 1(b), to exercise this Warrant with
respect to the maximum number of Warrant Shares purchasable pursuant to the
cashless exercise procedure set forth in subsection 1(b).

Notwithstanding anything to the contrary contained herein, this Purchase Form
shall constitute a representation by the holder of the Warrant submitting this
Purchase Form that, after giving effect to the exercise provided for in this
Purchase Form, such holder (together with its affiliates) will not have
beneficial ownership (together with the beneficial ownership of such Person’s
affiliates) of a number of shares of Common Stock which exceeds the Maximum
Percentage of the total outstanding shares of Common Stock as determined
pursuant to the provisions of Section 1(e) of this Warrant.

 

Signature:  

 

Address:  

 

 

 

--------------------------------------------------------------------------------

EXHIBIT II

ASSIGNMENT FORM

FOR VALUE RECEIVED,                                                   hereby
sells, assigns and transfers all of the rights of the undersigned under the
attached Warrant (No.     ) with respect to the number of shares of Common Stock
of Cardium Therapeutics, Inc. covered thereby set forth below, unto:

 

Name of Assignee

  

Address

  

No. of Shares

                             

Dated:                     

Signature:                     

Signature Guaranteed:                                                  

By:                                          

The signature should be guaranteed by an eligible guarantor institution (banks,
stockbrokers, savings and loan associations and credit unions with membership in
an approved signature guarantee medallion program) pursuant to Rule 17Ad-15
under the Securities Exchange Act of 1934, as amended.

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Exhibit C

Cardium Therapeutics, Inc.

Confidential Purchaser Questionnaire

Before any sale of Shares or Warrants by Cardium Therapeutics, Inc. can be made
to you, this Questionnaire must be completed and returned to Oppenheimer & Co.
Inc. Attn: Investment Banking Department, 125 Broad St., New York, NY 10004,
FAX: 212-425-2028

 

1. IF YOU ARE AN INDIVIDUAL PLEASE FILL IN THE IDENTIFICATION QUESTIONS IN
(A) IF YOU ARE AN ENTITY PLEASE FILL IN THE IDENTIFICATION QUESTIONS IN (B)

A. INDIVIDUAL IDENTIFICATION QUESTIONS

Name                                      
                                        
                                        
                                        
                                                                               

(Exact name as it should appear on stock certificate)

Residence Address                                   
                                        
                                        
                                        
                                                         

Home Telephone Number                                 
                                        
                                        
                                        
                                              

Fax Number                                    
                                        
                                        
                                        
                                                                    

Date of Birth                                  
                                        
                                        
                                        
                                                                     

Social Security Number                                 
                                        
                                        
                                        
                                                  

 

B. IDENTIFICATION QUESTIONS FOR ENTITIES

Name                                      
                                        
                                        
                                        
                                                                               

          (Exact name as it will appear on stock certificate)

Address of Principal Place of Business                            
                                        
                                        
                                                                  

State (or Country) of Formation or Incorporation                         
                                        
                                        
                                                  

Contact Person                                   
                                        
                                        
                                        
                                                                

Telephone Number (        )                        
                                        
                                        
                                        
                                                      

Type of Entity

(corporation, partnership, trust, etc.)                             
                                        
                                        
                                                                      

Was entity formed for the purpose of this investment?

Yes ¨    No ¨

 

2. DESCRIPTION OF INVESTOR

The following information is required to ascertain whether you would be deemed
an “accredited investor” as defined in Rule 501 of Regulation D under the
Securities Act. Please check whether you are any of the following:

 

  ¨  

a corporation or partnership with total assets in excess of $5,000,000, not
organized for the purpose of this particular investment

 

  ¨  

private business development company as defined in Section 202(a)(22) of the
Investment Advisers Act of 1940, a U.S. venture capital fund which invests
primarily through private placements in non-publicly traded securities and makes
available (either directly or through co-investors) to the portfolio companies
significant guidance concerning management, operations or business objectives

 

  ¨  

a Small Business Investment Company licensed by the U.S. Small Business
Administration under Section 301(c) or (d) of the Small Business Investment Act
of 1958

 

  ¨  

an investment company registered under the Investment Company Act of 1940 or a
business development company as defined in Section 2(a)(48) of that Act

--------------------------------------------------------------------------------

  ¨ a trust not organized to make this particular investment, with total assets
in excess of $5,000,000 whose purchase is directed by a sophisticated person as
described in Rule 506(b)(2)(ii) of the Securities Act of 1933 and who completed
item 4 below of this questionnaire

 

  ¨ a bank as defined in Section 3(a)(2) or a savings and loan association or
other institution defined in Section 3(a)(5)(A) of the Securities Act of 1933
acting in either an individual or fiduciary capacity

 

  ¨ an insurance company as defined in Section 2(13) of the Securities Act of
1933

 

  ¨ an employee benefit plan within the meaning of Title I of the Employee
Retirement Income Security Act of 1974 (i) whose investment decision is made by
a fiduciary which is either a bank, savings and loan association, insurance
company, or registered investment advisor, or (ii) whose total assets exceed
$5,000,000, or (iii) if a self-directed plan, whose investment decisions are
made solely by a person who is an accredited investor and who completed Part I
of this questionnaire;

 

  ¨ a charitable, religious, educational or other organization described in
Section 501(c)(3) of the Internal Revenue Code, not formed for the purpose of
this investment, with total assets in excess of $5,000,000

 

  ¨ an entity not located in the U.S. none of whose equity owners are U.S.
citizens or U.S. residents

 

  ¨ a broker or dealer registered under Section 15 of the Securities Exchange
Act of 1934

 

  ¨ a plan having assets exceeding $5,000,000 established and maintained by a
government agency for its employees

 

  ¨ an individual who had individual income from all sources during each of the
last two years in excess of $200,000 or the joint income of you and your spouse
(if married) from all sources during each of such years in excess of $300,000
and who reasonably excepts that either your own income from all sources during
the current year will exceed $200,000 or the joint income of you and your spouse
(if married) from all sources during the current year will exceed $300,000

 

  ¨ an individual whose net worth as of the date you purchase the securities
offered, together with the net worth of your spouse, be in excess of $1,000,000

 

  ¨ an entity in which all of the equity owners are accredited investors

 

3. BUSINESS, INVESTMENT AND EDUCATIONAL EXPERIENCE

Occupation                                     
                                        
                                        
                                        
                                                            

Number of Years                                  
                                        
                                        
                                        
                                                    

Present Employer                                   
                                        
                                        
                                        
                                                  

Position/Title                                    
                                        
                                        
                                        
                                                         

Educational Background                                  
                                        
                                        
                                                                              

 

- 2 -

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Frequency of prior investment (check one in each column):

 

     Stocks & Bonds    Venture Capital Investments

Frequently

     

Occasionally

     

Never

     

 

4. SIGNATURE

The above information is true and correct. The undersigned recognizes that the
Company and its counsel are relying on the truth and accuracy of such
information in reliance on the exemption contained in Subsection 4(2) of the
Securities Act of 1933, as amended, and Regulation D promulgated thereunder. The
undersigned agrees to notify the Company promptly of any changes in the
foregoing information, which may occur prior to the investment.

Executed at             , on     , 2007

 

 

(Signature)

 

- 3 -

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Exhibit D

Selling Stockholder Questionnaire

 

To: Cardium Therapeutics, Inc.

c/o Fisher Thurber LLP

4225 Executive Square,

Suite 1600

La Jolla, CA. 92037

Attention: Mr. David A. Fisher

Reference is made to the Securities Purchase Agreement (the “Agreement”), made
between Cardium Therapeutics, Inc., a Delaware corporation (the “Company”), and
the Purchasers noted therein.

Pursuant to Section B(12) of the Agreement, the undersigned hereby furnishes to
the Company the following information for use by the Company in connection with
the preparation of the Registration Statement contemplated by Section E of the
Agreement.

(1) Name and Contact Information:

 

Full legal name of record holder:

  

 

Address of record holder:

  

 

  

 

Social Security Number or Taxpayer identification number of record holder:   

 

Identity of beneficial owner (if different than record holder):

  

 

Name of contact person:

  

 

Telephone number of contact person:

  

 

Fax number of contact person:

  

 

E-mail address of contact person:

  

 

--------------------------------------------------------------------------------

  (2) Beneficial Ownership of Registrable Securities:

(a) Number of Registrable Securities owned by Selling Stockholder:

 

 

--------------------------------------------------------------------------------

(b) Number of Registrable Securities requested to be registered:

 

 

--------------------------------------------------------------------------------

 

  (3) Beneficial Ownership of Other Securities of the Company Owned by the
Selling Stockholder:

Except as set forth below in this Item (3), the undersigned is not the
beneficial or registered owner of any securities of the Company other than the
Registrable Securities listed above in Item (2)(a).

Type and amount of other securities beneficially owned by the Selling
Stockholder:

 

 

--------------------------------------------------------------------------------

 

 

--------------------------------------------------------------------------------

 

  (4) Relationships with the Company:

Except as set forth below, neither the undersigned nor any of its affiliates,
officers, directors or principal equity holders (5% or more) has held any
position or office or has had any other material relationship with the Company
(or its predecessors or affiliates) during the past three years.

State any exceptions here:

 

 

--------------------------------------------------------------------------------

 

 

--------------------------------------------------------------------------------

 

  (5) Plan of Distribution:

Except as set forth below, the undersigned intends to distribute pursuant to the
Registration Statement the Registrable Securities listed above in Item (2) in
accordance with the “Plan of Distribution” section set forth therein:

State any exceptions here:

 

 

--------------------------------------------------------------------------------

 

 

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- 2 -

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  (6) Selling Stockholder Affiliations:

(a) Is the Selling Stockholder a registered broker-dealer?

 

 

--------------------------------------------------------------------------------

(b) Is the Selling Stockholder an affiliate of a registered broker-dealer(s)?
(For purposes of this response, an “affiliate” of, or person “affiliated” with,
a specified person, is a person that directly, or indirectly through one or more
intermediaries, controls or is controlled by, or is under common control with,
the person specified.)

 

 

--------------------------------------------------------------------------------

(c) If the answer to Item (6)(b) is yes, identify the registered
broker-dealer(s) and describe the nature of the affiliation(s):

 

 

--------------------------------------------------------------------------------

(d) If the answer to Item (6)(b) is yes, did the Selling Stockholder acquire the
Registrable Securities in the ordinary course of business (if not, please
explain)?

 

 

--------------------------------------------------------------------------------

(e) If the answer to Item (6)(b) is yes, did the Selling Stockholder, at the
time of purchase of the Registrable Securities, have any agreements, plans or
understandings, directly or indirectly, with any person to distribute the
Registrable Securities (if yes, please explain)?

 

 

--------------------------------------------------------------------------------

 

  (7) Voting or Investment Control over the Registrable Securities:

If the Selling Stockholder is not a natural person, please identify the natural
person or persons who have voting or investment control over the Registrable
Securities listed in Item (2) above:

 

 

--------------------------------------------------------------------------------

Pursuant to Section E(3) of the Agreement, the undersigned acknowledges that the
Company may, by notice to the Placement Agent and to each Purchaser at its last
known address, suspend or withdraw the Registration Statement and require that
the undersigned immediately cease sales of Registrable Securities pursuant to
the Registration Statement under certain circumstances described in the
Agreement. At any time that such notice has been given, the undersigned may not
sell Registrable Securities pursuant to the Registration Statement.

 

- 3 -

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The undersigned hereby acknowledges receipt of a draft of the Registration
Statement dated [            ], 2007 and confirms that the undersigned has
reviewed such draft including, without limitation, the sections captioned
“Selling Stockholders” and “Plan of Distribution,” and confirms that, to the
best of the undersigned’s knowledge, the same is true, complete and accurate in
every respect except as indicated in this Questionnaire. The undersigned hereby
further acknowledges that pursuant to Section B(12) of the Agreement, the
undersigned shall indemnify the Company and each of its directors and officers
against, and hold the Company and each of its directors and officers harmless
from, any losses, claims, damages, expenses or liabilities (including reasonable
attorneys fees) to which the Company or its directors and officers may become
subject by reason of any statement or omission in the Registration Statement
made in reliance upon, or in conformity with, a written statement by the
undersigned, including the information furnished in this Questionnaire by the
undersigned.

By signing below, the undersigned consents to the disclosure of the information
contained herein in its answers to Items (1) through (7) above and the inclusion
of such information in the Registration Statement, any amendments thereto and
the related prospectus. The undersigned understands that such information will
be relied upon by the Company in connection with the preparation or amendment of
the Registration Statement and the related prospectus.

The undersigned has reviewed the answers to the above questions and affirms that
the same are true, complete and accurate. THE UNDERSIGNED AGREES TO NOTIFY THE
COMPANY IMMEDIATELY OF ANY CHANGES IN THE FOREGOING INFORMATION.

 

Dated:                                      , 2007

      Signature of Record Holder   (Please sign your name in exactly the same
manner as the certificate(s) for the shares being registered)  

 

- 4 -

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Exhibit E

Plan of Distribution

We are registering the shares offered by this prospectus on behalf of the
selling stockholders. The selling stockholders, which as used herein includes
donees, pledgees, transferees or other successors-in-interest selling shares of
common stock or interests in shares of common stock received after the date of
this prospectus from a selling stockholder as a gift, pledge, partnership
distribution or other transfer, may, from time to time, sell, transfer or
otherwise dispose of any or all of their shares of common stock or interests in
shares of common stock on any stock exchange, market or trading facility on
which the shares are traded or in private transactions. These dispositions may
be at fixed prices, at prevailing market prices at the time of sale, at prices
related to the prevailing market price, at varying prices determined at the time
of sale, or at negotiated prices. To the extent any of the selling stockholders
gift, pledge or otherwise transfer the shares offered hereby, such transferees
may offer and sell the shares from time to time under this prospectus, provided
that this prospectus has been amended under Rule 424(b)(3) or other applicable
provision of the Securities Act to include the name of such transferee in the
list of selling stockholders under this prospectus.

The selling stockholders may use any one or more of the following methods when
disposing of shares or interests therein:

 

  •  

ordinary brokerage transactions and transactions in which the broker-dealer
solicits purchasers;

 

  •  

block trades in which the broker-dealer will attempt to sell the shares as
agent, but may position and resell a portion of the block as principal to
facilitate the transaction;

 

  •  

purchases by a broker-dealer as principal and resale by the broker-dealer for
its account;

 

  •  

an exchange distribution in accordance with the rules of the applicable
exchange;

 

  •  

privately negotiated transactions;

 

  •  

short sales;

 

  •  

through the writing or settlement of options or other hedging transactions,
whether through an options exchange or otherwise;

 

  •  

broker-dealers may agree with the selling stockholders to sell a specified
number of such shares at a stipulated price per share;

 

  •  

a combination of any such methods of sale; and

 

  •  

any other method permitted pursuant to applicable law.

--------------------------------------------------------------------------------

The selling stockholders may, from time to time, pledge or grant a security
interest in some or all of the shares of common stock owned by them and, if they
default in the performance of their secured obligations, the pledgees or secured
parties may offer and sell the shares of common stock, from time to time, under
this prospectus, or under an amendment to this prospectus under Rule 424(b)(3)
or other applicable provision of the Securities Act amending the list of selling
stockholders to include the pledgee, transferee or other successors in interest
as selling stockholders under this prospectus.

In connection with the sale of our common stock or interests therein, the
selling stockholders may enter into hedging transactions with broker-dealers or
other financial institutions, which may in turn engage in short sales of the
common stock in the course of hedging the positions they assume. The selling
stockholders may also sell shares of our common stock short and deliver these
securities to close out their short positions, or loan or pledge the common
stock to broker-dealers that in turn may sell these securities. The selling
stockholders may also enter into option or other transactions with
broker-dealers or other financial institutions or the creation of one or more
derivative securities which require the delivery to such broker-dealer or other
financial institution of shares offered by this prospectus, which shares such
broker-dealer or other financial institution may resell pursuant to this
prospectus (as supplemented or amended to reflect such transaction).

The aggregate proceeds to the selling stockholders from the sale of the common
stock offered by them will be the purchase price of the common stock less
discounts or commissions, if any. Each of the selling stockholders reserves the
right to accept and, together with their agents from time to time, to reject, in
whole or in part, any proposed purchase of common stock to be made directly or
through agents. We will not receive any of the proceeds from this offering. Upon
any exercise of the warrants by payment of cash, however, we will receive the
exercise price of the warrants.

The selling stockholders also may resell all or a portion of the shares in open
market transactions in reliance upon Rule 144 under the Securities Act of 1933,
provided that they meet the criteria and conform to the requirements of that
rule.

The selling shareholders might be, and any broker-dealers that act in connection
with the sale of securities will be, deemed to be “underwriters” within the
meaning of Section 2(11) of the Securities Act, and any commissions received by
such broker-dealers and any profit on the resale of the securities sold by them
while acting as principals will be deemed to be underwriting discounts or
commissions under the Securities Act.

To the extent required, the shares of our common stock to be sold, the names of
the selling stockholders, the respective purchase prices and public offering
prices, the names of any agents, dealer or underwriter, any applicable
commissions or discounts with respect to a particular offer will be set forth in
an accompanying prospectus supplement or, if appropriate, a post-effective
amendment to the registration statement that includes this prospectus.

 

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In order to comply with the securities laws of some states, if applicable, the
common stock may be sold in these jurisdictions only through registered or
licensed brokers or dealers. In addition, in some states the common stock may
not be sold unless it has been registered or qualified for sale or an exemption
from registration or qualification requirements is available and is complied
with.

We have advised the selling stockholders that the anti-manipulation rules of
Regulation M under the Exchange Act may apply to sales of shares in the market
and to the activities of the selling stockholders and their affiliates. In
addition, we will make copies of this prospectus (as it may be supplemented or
amended from time to time) available to the selling stockholders for the purpose
of satisfying the prospectus delivery requirements of the Securities Act. The
selling stockholders may indemnify any broker-dealer that participates in
transactions involving the sale of the shares against certain liabilities,
including liabilities arising under the Securities Act.

We have agreed to indemnify the selling stockholders against liabilities,
including liabilities under the Securities Act and state securities laws,
relating to the registration of the shares offered by this prospectus.

We have agreed with the selling stockholders to keep the registration statement
that includes this prospectus effective until the earlier of (1) such time as
all of the shares covered by this prospectus have been disposed of pursuant to
and in accordance with the registration statement or (2) the date on which the
shares may be sold pursuant to Rule 144(k) of the Securities Act.

 

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