EXHIBIT 10.47

April 5, 2002

Marianne Armstrong, Ph.D
64 Mountain View Avenue
Mill Valley, CA 94941

Dear Marianne:

        On behalf of InterMune, Inc. (the "Company"), we are pleased to offer
you the position of Senior Vice President of Global Regulatory Operations and
Corporate Compliance, reporting to Dr. Scott Harkonen, the Company's CEO.

        The terms of your employment will be as follows:

        You will receive a base salary of $20,000 per month, paid on a
semi-monthly basis. In addition, the Company will provide you with a one-time
sign-on bonus of $30,000 (plus tax gross up) to be paid one month following your
first day of employment, that is subject to repayment in full if your employment
terminates before one year. In the event Genentech, Inc. requires repayment in
full or for any part of the Eighty-Five Thousand Dollar ($85,000) taxable
subsidy income afforded to you, then the Company will repay the requested
amount.

        Also, the Company will lend to you $345,000 to repay the interest-free
loan of Three Hundred Seventy-Five Thousand Dollars ($375,000) carried by
Genentech, Inc. on your property at 64 Mountain View Avenue, Mill Valley,
California. (Based on the terms of the promissory note dated May 25, 2000
between yourself and Genentech, Inc., Thirty Thousand Dollars ($30,000) of the
loan was forgiven on May 25, 2001.) The term of the loan will be five years, and
the other terms and conditions of this loan will be governed by a loan agreement
that you will be required to sign.

        As a full-time employee of the Company, you will be eligible for the
Company's standard benefits package including medical and dental as well as the
employee stock purchase program, 401K Retirement Plan and our Flexible Spending
Plan. Your position is exempt, and you will not be eligible for overtime.

        Subject to approval of the Compensation Committee of the Company's Board
of Directors, you will be granted an option to purchase 85,000 shares of the
Company's common stock. Your right to exercise the shares of this option will be
subject to a vesting schedule, such that 85,000 shares of your option will be
fully vested at the end of four years completed employment. The grant will be
made by the Compensation Committee of the Company's Board of Directors at its
next meeting after your first day of employment. The exercise price will be the
same as the closing price of the Company's Common Stock on the Nasdaq Exchange
on the day before the meeting. Your vesting will begin on your first day of your
employment with us; however, it is subject to a one-year cliff. The terms and
conditions of this option, including vesting, will be governed by an agreement
that you will be required to sign.

        As a condition of your employment, you will be required to provide proof
of U.S. citizenship or that you are legally entitled to work in the United
States, and to execute and be bound by the terms of the enclosed Proprietary
Information and Inventions Agreement. In that regard, please be aware that
Company policy prohibits all employees from bringing to the Company, or using in
performance of their responsibilities at the Company, any confidential
information, trade secrets, or proprietary material or processes of any previous
employer. Employment with the Company is at will, is not for any specific term
and can be terminated by you or the Company at any time for any reason with or
without cause.

        This offer remains open through end of the day April 5, 2002. Upon your
acceptance of this offer, the terms described in this letter and in the
Proprietary Information and Inventions Agreement shall be the terms of your
employment, superseding and terminating any other employment agreements or
understandings with InterMune, whether written or oral. Any additions or
modifications of these terms

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must be in writing and signed by you and an officer of the Company. Your
anticipated start date is May 1, 2002.

        Again, let me indicate how pleased we are to extend this offer, and how
much we at InterMune look forward to working with you. We anticipate that you
will find this an exciting and challenging position in a dynamic and growing
company.

        Please accept this offer by signing and returning the enclosed duplicate
original of this letter to me. If you have any questions, please call me or
Mireya Ono in the office.

Very truly yours,    
/s/ Stephen N. Rosenfield
Stephen N. Rosenfield
Senior Vice President of Legal Affairs
 
 
UNDERSTOOD AND ACCEPTED:
 
 
/s/ Marianne Armstrong                                        4/ 18/02

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Marianne Armstrong, Ph.D                                      Date
 
 

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