Exhibit 10.1

SECOND AMENDMENT TO
MULTI-TENANT INDUSTRIAL/COMMERCIAL LEASE (NET)

THIS SECOND AMENDMENT TO MULTI-TENANT INDUSTRIAL/ COMMERCIAL LEASE (NET) dated
April 28, 2015 (this “Second Amendment”) is entered into by and between WESTCORE
GREENVILLE, LLC, a Delaware limited liability company (“Lessor”), and ZELTIQ
AESTHETICS, INC., a Delaware corporation (“Lessee”), with reference to the
following:

R E C I T A L S

WHEREAS, Lessor and Lessee entered into that certain Multi-Tenant
Industrial/Commercial Lease (Net) dated October 3, 2013, as amended by that
certain First Amendment to Multi-Tenant Industrial/Commercial Lease (Net) dated
May 5, 2014 by and between Lessor and Lessee (collectively, the “Lease”), for
the lease of certain premises (the “Premises”), consisting of approximately
15,755 square feet, commonly known as Suite G located at 7085 Las Positas Road,
Livermore, California. All capitalized terms used herein and not otherwise
defined herein shall have the meanings ascribed to such terms in the Lease; and

WHEREAS, Lessor and Lessee desire by this Second Amendment to amend the Lease in
order to, among other things, (a) extend the Term for an additional seventeen
(17) month period; (b) provide for the Base Rent to be paid by Lessee for the
Premises during the Second Extension Term (as defined below); and (c) further
amend, modify and supplement the Lease as set forth herein.

NOW, THEREFORE, in consideration of the Premises and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged,
Lessor and Lessee hereby agree as follows:

1.    Recitals. The Recitals set forth above are incorporated herein as though
set forth in full herein.

2.    Extension of Term. Lessor and Lessee acknowledge that the term of the
Lease expires according to its terms on December 31, 2015. Notwithstanding
anything to the contrary contained in the Lease, Lessor and Lessee agree that
provided that Lessee is at no time in Breach under the Lease prior to December
31, 2015, the Expiration Date shall be extended such that the Lease shall
terminate on May 31, 2017 (the “New Expiration Date”), unless sooner terminated
in accordance with the terms of the Lease. The period from January 1, 2016
through the New Expiration Date shall be referred to herein as the “Second
Extension Term.” Lessee acknowledges that Lessee has no option or right to
extend the term of the Lease beyond the Second Extension Term.

3.    Base Rent During the Second Extension Term. Notwithstanding anything in
the Lease to the contrary and in addition to paying all other amounts due under
the Lease, including without limitation Lessee’s Share of Common Area Operating
Expenses, Lessee shall pay monthly Base Rent for the Premises during the Second
Extension Term according to the following schedule:

Period                Monthly Base Rent
January 1, 2016 - May 31, 2017         $9,768.10

4.    Condition of the Premises. Lessee acknowledges that it has been and
continues to be in possession of the Premises, is familiar with the condition of
the Premises and accepts the Premises in its presently existing, “as is”
condition, with all faults and without representation, warranty or improvements
by Lessor of any kind whatsoever. Lessor hereby informs Lessee that the Premises
have not undergone inspection by a Certified Access Specialist (“CASp”). The
foregoing verification is included in this Second Amendment solely for the
purpose of complying with California Civil Code Section 1938 and shall not in
any manner affect Lessor’s and Lessee’s respective responsibilities for
compliance with construction-related accessibility standards as provided under
the Lease. Lessee hereby waives any and all rights under and benefits of
California Civil Code Section 1938 and acknowledges that neither the Industrial
Center nor the Premises have undergone inspection by a CASp.

5.    Estoppel. Lessee hereby certifies and acknowledges, that as of the date
hereof (a) Lessor is not in default in any respect under the Lease, (b) Lessee
does not have any defenses to its obligations under the Lease, (c) Lessor is
holding a

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security deposit in the amount of $11,028.50 under the Lease, and (d) there are
no offsets against rent payable under the Lease. Lessee acknowledges and agrees
that: (i) the representations herein set forth constitute a material
consideration to Lessor in entering into this Second Amendment; (ii) such
representations are being made by Lessee for purposes of inducing Lessor to
enter into this Second Amendment; and (iii) Lessor is relying on such
representations in entering into this Second Amendment.

6.    Brokers. Lessee hereby represents and warrants to Lessor that Lessee has
not entered into any agreement or taken any other action which might result in
any obligation on the part of Lessor to pay any brokerage commission, finder’s
fee or other compensation with respect to this Second Amendment, other than to
Lee & Associates and CBRE, and Lessee agrees to indemnify and hold Lessor
harmless from and against any losses, damages, costs or expenses (including
without limitation, attorneys’ fees) incurred by Lessor by reason of any breach
or inaccuracy of such representation or warranty.

7.    Utility Bills. Upon Lessor’s request, Lessee shall deliver to Lessor
copies of all bills for separately metered utilities supplied to the Premises
for the past twelve (12) month period within thirty (30) days of Lessor’s
request. Lessee shall provide all necessary authorizations for Lessor to obtain
any bills relating to utility usage at the Premises directly from the utility
provider, including delivering a signed and completed original of the
authorization form attached as Exhibit A to this Second Amendment to Lessor
concurrently with Lessee’s execution and delivery of this Second Amendment to
Lessor. If Lessor is unable to obtain the information from the utility provider,
Lessee shall provide copies of all utility bills relating to the Premises
received after the date of this Second Amendment within ten (10) days of
receipt.

8.    Lessor’s Limitation of Liability. It is expressly understood and agreed
that notwithstanding anything in the Lease (as hereby amended) to the contrary,
and notwithstanding any applicable law to the contrary, the liability of Lessor
under the Lease, as hereby amended (including any successor Lessor) and any
recourse by Lessee against Lessor shall be limited solely and exclusively to the
interest of Lessor in and to the Premises, and neither Lessor, nor any of its
constituent partners or members, shall have any personal liability therefor, and
Lessee hereby expressly waives and releases such personal liability on behalf of
itself and all persons claiming by, through or under Lessee. Under no
circumstances shall Lessor be liable for injury to Lessee’s business or for any
loss of income or profit therefrom.

9.    Lessor Exculpation. No present or future officer, director, employee,
trustee, partner, member, manager or agent of Lessor shall have any personal
liability, directly or indirectly, and recourse shall not be had against any
such officer, director, employee, trustee, partner, member, manager or agent
under or in connection with the Lease, as hereby amended, or any other document
or instrument heretofore or hereafter executed in connection with the Lease, as
hereby amended. Lessee hereby waives and releases any and all such personal
liability and recourse. The limitations of liability provided in this Section
are in addition to, and not in limitation of, any limitation on liability
applicable to Lessor provided by law or in any other contract, agreement or
instrument.

10. Ratification. Except as otherwise specifically herein amended, the Lease is
and shall remain in full force and effect according to the terms thereof. In the
event of any conflict between the Lease and this Second Amendment, this Second
Amendment shall control.

11.    Attorneys’ Fees. Should either party institute any action or proceeding
to enforce or interpret this Second Amendment or any provision thereof, for
damages by reason of any alleged breach of this Second Amendment or of any
provision hereof, or for a declaration of rights hereunder, the prevailing party
in any such action or proceeding shall be entitled to receive from the other
party all cost and expenses, including actual attorneys’ and other fees,
reasonably incurred in good faith by the prevailing party in connection with
such action or proceeding. The term “attorneys’ and other fees” shall mean and
include attorneys’ fees, accountants’ fees, and any and all consultants’ and
other similar fees incurred in connection with the action or proceeding and
preparations therefore. The term “action or proceeding” shall mean and include
actions, proceedings, suits, arbitrations, appeals and other similar
proceedings.

12.    Submission. Submission of this Second Amendment by Lessor to Lessee for
examination and/or execution shall not in any manner bind Lessor and no
obligations on Lessor shall arise under this Second Amendment unless and until
this Second Amendment is fully signed and delivered by Lessor and Lessee;
provided, however, the execution and delivery by Lessee of this Second Amendment
to Lessor shall constitute an irrevocable offer by Lessee of the terms and
conditions herein contained, which offer may not be revoked for thirty (30) days
after such delivery.

13.    Counterparts. This Second Amendment may be executed in several
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same agreement.

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IN WITNESS WHEREOF, this Second Amendment has been executed by the parties as of
the date first referenced above.

“Lessor”

WESTCORE GREENVILLE, LLC,
a Delaware limited liability company

By: WP Investments I, LLC,
a Delaware limited liability company
its sole member

By:    Westcore Properties, LLC,
a Delaware limited liability company,
its sole member

By: /s/ Matthew Bateman
Name: Matthew Bateman
Title: Authorized Signatory

“Lessee”

ZELTIQ AESTHETICS, INC.,
a Delaware corporation

By: /s/ Patrick F. Williams
Name: Patrick F. Williams
Title: Sr. Vice President & Chief Financial Officer

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EXHIBIT A

UTILITY PROVIDER AUTHORIZATION

AUTHORIZATION TO: RECEIVE CUSTOMER
SUBMITTED TO THE FOLLOWING.

INFORMATION OR ACT ON A CUSTOMER'S BEHALF
Please check all that apply:

__ PG&E    __ SoCalGas
__ SCE    __ SDG&E
THIS IS A LEGALLY BINDING CONTRACT-READ IT CAREFULLY
(Please Print or Type)
I,
____________________________________________________________________________________________________
NAME                         TITLE (IF APPLICABLE

of ___________________________________________________________ (Customer) have
the following mailing address
NAME OF CUSTOMER OF RECORD
_________________________________________________________________________________,
and do hereby appoint
MAILING ADDRESS        CITY         STATE         ZIP
_______________________________________________ of
____________________________________________________
NAME OF THIRD PARTY                    MAILING ADDRESS    
______________________________________________________________________________________________________
CITY                             STATE             ZIP

to act as my agent and consultant (Agent) for the listed account(s) and in the
categories indicated below:

ACCOUNTS INCLUDED IN THIS AUTHORIZATION:

1.____________________________________________________
_________________________________________
SERVICE ADDRESS         CITY                  SERVICE ACCOUNT NUMBER
2. ____________________________________________________
_________________________________________
SERVICE ADDRESS         CITY                  SERVICE ACCOUNT NUMBER
3. ____________________________________________________
_________________________________________
SERVICE ADDRESS         CITY                  SERVICE ACCOUNT NUMBER

(For more than three accounts,please list additional accounts on a separate
sheet and attach it to this form)

INFORMATION, ACTS AND FUNCTIONS AUTHORIZED- This authorization provides
authority to the Agent. The Agent must thereafter provide specific written
instructions/requests (e-mail is acceptable) about the particular account(s)
before any information is released or action is taken. In certain instances,the
requested act or function may result in cost to you,the customer. Requests for
information may be limited to the most recent 12 month period.

I (Customer) authorize my Agent to act on my behalf to perform the following
specific acts and functions (initial all applicable boxes):
____ 1. Request and receive billing records, billing history and all meter usage
data used for bill calculation for all of my account(s),as specified
herein,regarding utility services furnished by the Utility1.
____ 2. Request and receive copies of correspondence in connection with my
account(s) concerning (initial all that apply):
____ a.    Verification of rate,date of rate change, and related information;
____ b.     Contracts and Service Agreements;
____ c.     Previous or proposed issuance of adjustments/credits;or
____ d.     Other previously issued or unresolved/disputed billing adjustments.
____3.    Request investigation of my utility bill(s).
____4.     Request special metering, and the right to access interval usage and
other metering data on my account(s).
____5.     Request rate analysis.
____6.     Request rate changes.
____7.     Request and receive verification of balances on my account(s) and
discontinuance notices.
1 The Utility will provide standard customer information without charge up to
two times in a 12 month period per service account. After two requests in a
year, I understand I may be responsible for charges that may be incurred to
process this request.

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AUTHORIZATION TO: RECEIVE CUSTOMER INFORMATION OR ACT ON A CUSTOMER'S BEHALF

I(CUSTOMER) AUTHORIZE THE RELEASE OF MY ACCOUNT INFORMATION AND AUTHORIZE MY
AGENT TO ACT ON MY BEHALF ON THE FOLLOWING BASIS2 (initial one box only):
21f no time period is specified, authorization will be limited to a one-time
authorization
____    One time authorization only (limited to a one-time request for
information and/or the acts and functions specified
above at the time of receipt of this Authorization).

____
One year authorization - Requests for information and/or for the acts and
functions specified above will be accepted and processed each time requested
within the twelve month period from the date of execution of this Authorization.

____
Authorization is given for the period commencing with the date of execution
until _______________________(Limited in duration to three years from the date
of execution.) Requests for information and/or for the acts and functions
specified above will be accepted and processed each time requested within the
authorization period specified herein.

RELEASE OF ACCOUNT INFORMATION:

The Utility will provide the information requested above,to the extent
available,via any one of the following. My
(Agent) preferred format is (check all that apply):

____    Hard copy via US Mail (if applicable).

____    Facsimile at this telephone number: ___________________________    

____    Electronic format via electronic mail(if applicable) to this e-mail
address: ______________________________    

I (Customer), ________________________________ (print name of authorized
signatory), declare under penalty of perjury under the laws of the State of
California that Iam authorized to execute this document on behalf of the
Customer of Record listed at the top of this form and that Ihave authority to
financially bind the Customer of Record. Ifurther certify that my Agent has
authority to act on my behalf and request the release of information for the
accounts listed on this form and perform the specific acts and functions listed
above. I understand the Utiity reserves the right to verify any authorization
request submitted before releasing information or taking any action on my
behalf. I authorize the Utility to release the requested information on my
account or facilties to the above Agent who is acting on my behalf regarding the
matters listed above. I hereby release, hold harmless, and indemnify the Utility
from any liability, claims, demands, causes of action, damages, or expenses
resulting from: 1) any release of information to my Agent pursuant to this
Authorziation; 2) the unauthorzied use of this information by my Agent; and 3)
from any actions taken by my Agent pursuant to this Authorization, including
rate changes. I understand that I may cancel this authorization at any time by
submitting a written request. [This form must be signed by someone who has
authority to financially bind the customer (for example, CFO of a company or
City Manager of a municipality).]

____________________________________________________
____________________________________________
AUTHORZIED CUSTOMER SIGNATURE                 TELEPHONE NUMBER

Executed this __________ day of ___________ __________    at
______________________________________.
             MONTH     YEAR         CITY AND STATE WHERE EXECUTED

I (Agent), hereby release, hold harmless, and indemnify the Utility from any
liability, claims, demand, causes of action, damages,or expenses resulting from
the release of customer information obtained pursuant to this authorization and
from the taking of any action pursuant to this authorization, including rate
changes.

____________________________________________________
____________________________________________
AGENT SIGNATURE                        TELEPHONE NUMBER
____________________________________________________
COMPANY

Executed this __________ day of ___________ __________    
             MONTH     YEAR