Exhibit 10.22(ii)
(CYDEX LOGO) [f58570f5857000.gif]
10513 W. 84th Terrace
Lenexa, KS 66214
P: 913.685.8850
F: 913.685.8856
www.cydexpharma.com
April 19, 2011
Via Federal Express
Onyx Pharmaceuticals
2100 Powell Street
Emeryville, California 94608
Attention: VP, Development

     Re:   Exhibit A to the License and Supply Agreement dated as of October 12,
2005, as amended (“Agreement”) between CyDex Pharmaceuticals, Inc. (formerly
known as CyDex, Inc., “CyDex”) Onyx Pharmaceuticals (formerly known as
Proteolix, Inc. (“Company”)

Dear Sir or Madam:
     Pursuant to Section 1.20 of the Agreement, CyDex has the right and
obligation to update Exhibit A to the Agreement which lists the “Licensed
Patents” which cover Captisol®. This letter is provided by CyDex to Company as
an official notice pursuant to Section 14.7 of the Agreement to so update such
Exhibit A.
     Accordingly, listed in Schedule A, attached hereto, is the complete list of
all patents and patent applications, which hereby replaces the existing
definition of Licensed Patents.
     Please contact the undersigned if you have any questions.
With best regards,
CYDEX PHARMACEUTICALS, INC.
-s- Allen K. Roberson [f58570f5857001.gif]
Allen K. Roberson, General Manager
Enclosure

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Schedule A
PATENT FAMILY 1: “Derivatives of Cyclodextrins Exhibiting Enhanced Aqueous
Solubility and the Use Thereof.”
Issued Patents

                      Filing Date           Expiration Date Country  
(mm/dd/yyyy)   Application No.   Patent No.   (mm/dd/yyyy) United States  
01/23/1990   07/469,087   5,134,127   01/23/2010 Australia   01/22/1991  
72364/91   646020   01/22/2011 Austria   01/22/1991   91903891.9   E 170742  
01/22/2011 Belgium   01/22/1991   91903891.9   512050   01/22/2011 Canada  
01/22/1991   2,074,186   2,074,186   01/22/2011 Europe   01/22/1991   91903891.9
  512050   01/22/2011 France   01/22/1991   91903891.9   512050   01/22/2011
Germany   01/22/1991   6030165.4-08   69130165   01/22/2011 Greece   01/22/1991
  980402865   3028691   01/22/2011 Italy   01/22/1991   70988BE/98   512050  
01/22/2011 Japan   01/22/1991   504051/93   2722277   01/22/2011 Luxembourg  
01/22/1991   91903891.9   512050   01/22/2011 Netherlands   01/22/1991  
91903891.9   512050   01/22/2011 Russia   01/22/1991   5052811.04   2099354  
01/22/2011 South Korea   01/22/1991   92-701734   166088   01/22/2011 Sweden  
01/22/1991   91903891.9   512050   01/22/2011 Switzerland   01/22/1991  
91903891.9   512050   01/22/2011 United Kingdom   01/22/1991   91903891.9  
512050   01/22/2011

PATENT FAMILY 2: “Derivatives of Cyclodextrins Exhibiting Enhanced Aqueous
Solubility and the Use Thereof.”
Issued Patents

                      Filing Date           Expiration Date Country  
(mm/dd/yyyy)   Application No.   Patent No.   (mm/dd/yyyy) United States  
07/27/1992   07/918,702   5,376,645   01/23/2010 Armenia   07/26/1993   96237  
822   07/26/2013 Australia   07/26/1993   47799/93   672814   07/26/2013 Austria
  07/26/1993   93918302   E 217325   07/26/2013

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                      Filing Date           Expiration Date Country  
(mm/dd/yyyy)   Application No.   Patent No.   (mm/dd/yyyy) Belgium   07/26/1993
  93918302.6   620828   07/26/2013 Canada   07/26/1993   2,119,154   2,119,154  
07/26/2013 Denmark   07/26/1993   93918302.6   620828   07/26/2013 Europe  
07/26/1993   93918302.6   620828   07/26/2013 France   07/26/1993   93918302.6  
620828   07/26/2013 Georgia   07/26/1993   1857   1649   07/26/2013 Germany  
07/26/1993   6031900   69331900   07/26/2013 Greece   07/26/1993   930620828  
3040489   07/26/2013 Ireland   07/26/1993   93918302.6   620828   07/26/2013
Italy   07/26/1993   70422BE/2002   620828   07/26/2013 Japan   07/26/1993  
6-504678/94   3393253   07/26/2013 Kyrgyzstan   07/26/1993   960481.1   333  
07/26/2013 Luxembourg   07/26/1993   93918302.6   620828   07/26/2013 Moldova  
07/26/1993   960306   1813   07/26/2013 Monaco   07/26/1993   93918302.6  
620828   07/26/2013 Netherlands   07/26/1993   93918302.6   620828   07/26/2013
Portugal   07/26/1993   93918302.6   620828   07/26/2013 Russia   07/26/1993  
94028890   2113442   07/26/2013 South Korea   07/26/1993   94-700951   279111  
07/26/2013 Spain   07/26/1993   93918302.6   620828   07/26/2013 Sweden  
07/26/1993   93918302.6   620828   07/26/2013 Switzerland   07/26/1993  
93918302.6   620828   07/26/2013 Tajikistan   07/26/1993   96000377   TJ 275  
07/26/2013 Turkmenistan   07/26/1993   393   430   07/26/2013 United Kingdom  
07/26/1993   93918302.6   620828   07/26/2013 Uzbekistan   07/26/1993  
IHAP9400808   5799   07/26/2013

PATENT FAMILY 15: “Sulfoalkyl Ether Cyclodextrin Compositions and Methods of
Preparation Thereof.”
Issued Patents

                      Filing Date           Expiration Date Country  
(mm/dd/yyyy)   Application No.   Patent No.   (mm/dd/yyyy) United States  
01/31/2009   12/363,719   7,629,331   10/26/2025 Europe*   10/26/2005  
05856927.8   1945228   10/26/2025

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Pending Applications

                                  Estimated Expiration     Filing Date          
Date Country   (mm/dd/yyyy)   Application No.   Publication No.   (mm/dd/yyyy)
United States   10/26/2005   12/108,228   2009/0011037   10/26/2025 Australia  
10/26/2005   2005337613   2005337613   10/26/2025 Brazil   10/26/2005  
PI0520654-5   Brazilian Industrial Property Journal No. 2002   10/26/2025 Canada
  10/26/2005   2,632,211   2,632,211   10/26/2025 China   10/26/2005  
200580052421.8   101365459A   10/26/2025 India   10/26/2005   3462/DELNP/2008  
Not yet published   10/26/2025 Israel   10/26/2005   191081   Not yet published
  10/26/2025 Japan   10/26/2005   2008-537669   2009-513773   10/26/2025 Mexico
  10/26/2005   MX/a/2008/005397   Not yet published   10/26/2025 South Korea  
10/26/2005   10-2008-7012541   10-20080063526   10/26/2025 Russia   10/26/2005  
2008120659   2008120659   10/26/2025

 

*   The grant date of EP 1945228 will be 04/06/2011.

PATENT FAMILY 20: “Sulfoalkyl Ether Cyclodextrin Compositions”
Issued Patents

                      Filing Date           Expiration Date Country  
(mm/dd/yyyy)   Application No.   Patent No.   (mm/dd/yyyy) United States  
03/13/2009   12/404,174   7,635,773   03/13/2029

Pending Applications

                                  Estimated Expiration     Filing Date          
Date Country   (mm/dd/yyyy)   Application No.   Publication No.   (mm/dd/yyyy)
United States   11/05/2009   12/613,103   2010/0093663   03/13/2029 Australia  
04/28/2009   2009241858   Not yet published   04/28/2029 Brazil   04/28/2009  
PI0905080-9   Not yet published   04/28/2029 Canada   04/28/2009   2,702,603  
Not yet published   04/28/2029 China   04/28/2009   200980107665.X   101959508  
04/28/2029

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                                  Estimated Expiration     Filing Date          
Date Country   (mm/dd/yyyy)   Application No.   Publication No.   (mm/dd/yyyy)
Eurasia   04/28/2009   201000828   Not yet published   04/28/2029 Europe  
04/28/2009   09739150.2   2268269   04/28/2029 India   04/28/2009   To be
determined   Not yet published   04/28/2029 Israel   04/28/2009   208956   Not
yet published   04/28/2029 Japan   04/28/2009   2010-525119   2010-539193  
04/28/2029 Mexico   04/28/2009   MX/a/2010/004900   MX/a/2010/004900  
04/28/2029 South Korea   04/28/2009   10-2010-7026534   Not yet published  
04/28/2029 New Zealand   04/28/2009   589290   Not yet published   04/28/2029

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