Exhibit 10.13

EMPLOYMENT AGREEMENT

THIS EMPLOYMENT AGREEMENT (the “Agreement”), is made as of the 22nd day of
December, 2005 (the “Effective Date”, by and between CV THERAPEUTICS, INC. (the
“Company”) and LOUIS G. LANGE (the “Executive”).

WHEREAS, the Company and the Executive have entered into that certain Amended
and Restated Executive Severance Benefits Agreement effective December 31, 2002
(the “Severance Agreement”);

WHEREAS, the Company and the Executive now wish this Agreement to supersede the
Severance Agreement and any other agreement relating to cash severance benefits
between the Executive and the Company in their entirety;

WHEREAS, the Company recognizes that the Executive can contribute to the growth
and success of the Company and desires to continue to employ the Executive on
the terms and conditions set forth in this Agreement;

WHEREAS, the Executive has been appointed by the Company’s Board of Directors
(the “Board”) to serve as the Chairman of the Board, Chief Executive Officer and
Chief Science Officer of the Company, and has been approved by the stockholders
of the Company to serve as a director of the Company; and

WHEREAS, the Executive desires to continue to be so employed by the Company.

NOW, THEREFORE, in consideration of the foregoing and the mutual covenants and
promises contained herein, and intending to be bound hereby, the parties agree
as follows:

1. Employment.

1.1. Term. The Company agrees to employ the Executive in accordance with the
terms of this Agreement and the Executive agrees to accept such terms of
employment, effective as of the Effective Date for a term of eight years (the
“Term”). Notwithstanding the foregoing, the Executive’s employment with the
Company shall be “at will,” and either the Executive or the Company may
terminate the Executive’s employment at any time, for any reason, with or
without Good Reason (as defined below) or with or without Cause (as defined
below); provided, that such termination is subject to the termination provisions
of Section 3 of this Agreement.

1.2. Positions. During the Term, the Executive will continue to serve as
Chairman of the Board, Chief Executive Officer and Chief Science Officer of the
Company, reporting directly to the Board. At all times during the Term, the
Executive shall serve as a member of the Board if so requested by the Executive.

1.3. Duties. The Executive will continue to perform such duties and functions as
are customarily performed by the chairman, chief executive officer and chief
science officer, of an enterprise the size and nature of the Company, including
the duties and functions from time

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to time assigned to him by the Board as are commensurate with such positions.
Without limiting the generality of the foregoing, the Executive will continue to
be responsible for all aspects of the Company’s performance, including strategy,
research and development, business development, sales and marketing, operations,
manufacturing, technology development and licensing, corporate development,
information management, finance, legal, patent, regulatory, human resources,
investor relations and corporate communications.

1.4. Place of Performance. The Executive shall continue to perform his services
hereunder at the principal executive offices of the Company, which are currently
located in Palo Alto, California; provided, however, that the Executive will be
required to travel from time to time for business purposes.

1.5. Time Devoted to Employment. The Executive will devote his best efforts and
substantially all of his business time and services to the performance of his
duties under this Agreement. Notwithstanding the foregoing, the Executive may
engage in charitable, community service and industry association activities and
upon notice to the Board, serve as a member of boards of directors of companies
not deemed to be engaged in competition with the Company and manage his own
finances so long as those activities do not interfere with the performance of
his duties under this Agreement as determined by the Board.

2. Compensation, Benefits and Expense Reimbursements.

2.1. Base Salary. The Company shall continue compensating the Executive while he
is employed as the Chief Executive Officer of the Company in the same manner
that it has done during his past and current employment with the Company. The
Executive shall receive a minimum annual salary of $600,000 (to be increased to
$624,000, effective January 1, 2006) (the “Base Salary”), paid semi-monthly or
otherwise in accordance with the Company’s customary payroll practices, as in
effect from time to time. As stated in the Company’s compensation philosophy
which is described annually in the Company’s Proxy Statement as filed with the
Securities and Exchange Commission on Schedule 14A (the “Proxy”), the
Compensation Committee of the Board (the “Compensation Committee”) shall review
the Executive’s Base Salary in relation to the Company’s comparator group and
the Executive’s peer group, and in relation to the Executive’s performance. In
accordance with an evaluation of such factors, the Compensation Committee may
increase the Executive’s Base Salary from time to time.

2.2. Bonus. The Company shall continue compensating the Executive while he is
employed as the Chief Executive Officer of the Company in the same manner that
it has done during his past and current employment with the Company. As stated
in the Company’s compensation philosophy which is described annually in the
Proxy, the Compensation Committee shall review the Executive’s annual bonus
compensation (“Annual Bonus”) in relation to the Company’s comparator group and
the Executive’s peer group, and in relation to the Company’s and the Executive’s
performance. In accordance with an evaluation of such factors, the Compensation
Committee will establish the Executive’s Annual Bonus; provided, that the target
Annual Bonus established by the Board during the Term shall be no less favorable
than the Executive’s target Annual Bonus as of the Effective Date.

 

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2.3. Long Term Incentive. The Executive shall be eligible to be granted
long-term incentive and equity compensation awards in the discretion of the
Compensation Committee and the Board based on the Compensation Committee’s
evaluation of the Executive’s performance and market and peer compensation.

2.4. Restricted Stock Units. Subject to approval of the Board, the Company shall
provide the Executive with a restricted stock unit (“RSU”) grant for 201,694
shares of the Company’s common stock. Ten percent of the shares of common stock
under the RSU shall vest as of the date of the grant and 5.625% of the shares of
common stock under the RSU shall vest at the end of each three month period
commencing on the date of grant (each a “Vesting Date”), so as to be 100% vested
on the fourth anniversary of the date of grant, subject to the Executive’s
continuous employment by the Company through the respective Vesting Date. The
vested shares of common stock subject to the RSU shall be distributed to the
Executive on each 12 month anniversary of their relevant vesting date. Executive
shall be permitted to satisfy the minimum tax withholding obligations arising
upon the vesting or receipt of the RSU shares, as applicable, by having the
Company withhold shares with a then fair market value equal to the minimum
amount required to be withheld.

2.5. Expenses. During the Term, the Executive will be entitled to reimbursement
by the Company for all expenses reasonably incurred by him in connection with
the performance of his duties, including, without limitation, travel and
entertainment expenses reasonably related to the business of the Company, in
accordance with the policies and procedures established from time to time by the
Company.

2.6. Automobile Allowance. During the Term, the Executive shall be entitled to a
monthly allowance of $1,000 for the use of an automobile.

2.7. Financial/Legal/IT Assistance. During the Term, the Executive shall be
entitled to reimbursement for financial, legal and IT support and assistance
expenses of up to $25,000 annually.

2.8. Other Benefits. During the Term, the Executive shall be entitled to
participate in any benefit plans, policies or arrangements sponsored or
maintained by the Company from time to time for its executive employees. In
addition to the foregoing, the Company shall provide the Executive supplemental
long-term disability insurance providing no less than $10,000 per month in
additional coverage; provided, that the Executive conforms to the insurance
company underwriting requirements. Notwithstanding the foregoing, the
Executive’s eligibility for and participation in any of the Company’s employee
benefit plans, policies or arrangements will be subject to the terms and
conditions of such plans, policies or arrangements as they apply to other senior
executives of the Company. Moreover, subject to the terms and conditions of such
plans, policies or arrangements, the Company may amend, modify or terminate such
plans, policies or arrangements at any time for any or no reason.

2.9. Attorney’s Fees. The Company shall reimburse the Executive for reasonable
attorney’s fees incurred by the Executive in connection with the negotiation of
this Agreement, not to exceed $30,000.

 

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3. Termination.

3.1. In General. The Company may terminate the Executive’s employment at any
time. The Executive may terminate his employment at any time. Upon any
termination of the Executive’s employment with the Company for any reason:
(i) the Executive (unless otherwise requested by the Board) concurrently will
resign any officer positions he holds with the Company, its subsidiaries or
affiliates; (ii) the Company will pay to the Executive all accrued but unpaid
Base Salary and all accrued and unused vacation days through the date of
termination; and (iii) except as explicitly provided in this Section 3, in
Section 6, or otherwise pursuant to the Consolidated Omnibus Budget
Reconciliation Act of 1985, as amended (“COBRA,”) or the California Continuation
Benefits Replacement Act, as amended (“Cal-COBRA”), all compensation and
benefits will cease and the Company will have no further liability or obligation
to the Executive.

3.2. Termination without Cause or for Good Reason.

3.2.1. If the Executive’s employment by the Company ceases due to a termination
by the Company without Cause or a resignation by the Executive for Good Reason
and the Executive executes and does not revoke a general release of claims
against the Company in substantially the form attached hereto as Exhibit A to
the Company (a “General Release”), then, the Company will pay to the Executive
(i) all accrued but unpaid Base Salary and all accrued and unused vacation days
through the date of termination; (ii) a cash amount equal to the sum of two
times the Executive’s Base Salary; (iii) a cash amount equal to two times the
Executive’s Average Annual Bonus, with such Average Annual Bonus determined by
adding the amounts payable to Executive under the Company’s annual bonus
programs for the three full calendar years prior to the year in which such
termination of employment occurs and dividing the resulting amount by three
(“Average Annual Bonus”); (iv) a cash payment equal to the Executive’s then
target Annual Bonus, multiplied by a fraction, the numerator of which is the
number of days in the Company’s fiscal year prior to such termination of
employment and the denominator of which is 365; and (v) group health, dental and
vision insurance coverage benefits equivalent to those, and on the same tax-free
basis as those, to which the Executive would have been entitled if he had
continued working for the Company for an additional 18 month period (or if less,
until Executive becomes covered under comparable plans of another employer),
after which period COBRA and/or Cal-COBRA shall become available to the
Executive such that the end of the first 18-month period will be the COBRA
“qualifying event” for Executive and his eligible dependents. In addition to the
foregoing, in the event of such termination of employment, (i) any options to
purchase the common stock of the Company previously granted to the Executive and
not otherwise vested shall be fully vested as of the date of the Executive’s
termination of employment; (ii) any “at-the-money” or “underwater” option grants
as of the Effective Date will have a post-termination exercise period extending
through the earliest of (A) 36 months following the Executive’s termination of
employment, (B) their original expiration date, or (C) such shorter period as
does not result in any adverse tax consequences to the Executive under
Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”);
(iii) any of Executive’s stock options that, as of the Effective Date, have a
per share exercise price that is less than the closing trading price of the
Company’s common stock on the Effective Date shall have a post-termination
exercise period extending through the later of (A) two and one-half months
beyond, or (B) December 31 following, the three month anniversary of the
Executive’s termination of employment (or their original expiration date, if
earlier); and (iv) the

 

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Executive’s previously granted RSUs shall become vested as to the amount of
additional shares the Executive would have been entitled if he had continued
working for the Company for an additional 12 month period.

3.2.2. For purposes of this Agreement, “Cause” means, unless the Executive fully
corrects the circumstances constituting Cause (provided such circumstances are
capable of correction) prior to the date of termination, the Executive:

(a) has willfully committed an improper act that materially injures the business
of the Company;

(b) has willfully and repeatedly refused or failed to follow specific, lawful
and reasonable directions of the Board (other than any such refusal or failure
resulting from the Executive’s incapacity due to physical or mental illness or
any such actual or anticipated failure after his issuance of a notice of
termination for Good Reason, as defined below), after a written demand for
substantial performance is delivered to the Executive by the Board, which demand
specifically identifies the manner in which the Board believes that the
Executive has willfully and repeatedly refused or failed to follow specific,
lawful and reasonable directions of the Board;

(c) has willfully, substantially and habitually neglected the Executive’s duties
for the Company (other than any such neglect resulting from the Executive’s
incapacity due to physical or mental illness or any such actual or anticipated
neglect after his issuance of a notice of termination for Good Reason, as
defined below), after a written demand for substantial performance is delivered
to the Executive by the Board, which demand specifically identifies the manner
in which the Board believes that the Executive has willfully, substantially and
habitually neglected his duties or services to the Company; or

(d) has been convicted of a felony or a crime involving moral turpitude;
provided, that for purposes of this agreement a traffic related offense
(including without limitation the offense of driving under the influence of
drugs or alcohol) shall not constitute a crime of moral turpitude.

For purposes of this Section 3.2.2, no act, or failure to act, on the
Executive’s part shall be deemed “willful” unless done, or omitted to be done,
by him not in good faith.

3.2.3. For purposes of this Agreement, “Good Reason” means any of the following
are undertaken without the Executive’s express written consent:

(a) the assignment to the Executive of any duties, authority or responsibilities
which results in a significant diminution in the Executive’s duties, authority
or responsibilities;

(b) any change in the Executive’s title from Chief Executive Officer;

(c) the Executive ceasing to report to the Board;

 

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(d) a reduction by the Company of the Executive’s Base Salary or target Annual
Bonus as of the Effective Date or as increased thereafter;

(e) a material reduction of the facilities and perquisites available to the
Executive immediately prior to such reduction, other than a reduction generally
applicable to all senior management of the Company;

(f) a material reduction by the Company in the aggregate level of employee
benefits, to which the Executive was entitled immediately prior to such
reduction with the result that the Executive’s aggregate benefits package is
materially reduced (other than a reduction that generally applies to Company
executive officers);

(g) a relocation of the Executive’s business office to a location more than 25
miles from the location at which the Executive performs duties as of the
Effective Date, except for required travel by the Executive on the Company’s
business;

(h) a material breach by the Company of any provision of this Agreement; or

(i) any failure by the Company to obtain the assumption of this Agreement by any
successor or assign of the Company.

3.3. Certain Terminations On or After a Change in Control.

3.3.1. Within 18 Months on or After a Change in Control. If the Executive’s
employment with the Company ceases within the 18 month period commencing on a
Change in Control (as defined below) as a result of a termination by the Company
without Cause or a resignation by the Executive for Good Reason and the
Executive executes and does not revoke a General Release, then the Company will
provide the Executive with the same payments and benefits as specified under
Section 3.2.1 hereof, except that the period of group health, dental and vision
coverage shall be extended from 18 to 24 months (or if less, until Executive
becomes covered under comparable plans of another employer), after which period
COBRA and/or Cal-COBRA shall become available to the Executive such that the end
of the first 24-month period will be the COBRA “qualifying event” for Executive
and his eligible dependents.

3.3.2. At Any Time Following a Change in Control. If the Executive’s employment
with the Company ceases at any time following a Change in Control as a result of
a termination by the Company without Cause or a resignation by the Executive for
Good Reason, and the Executive executes and does not revoke a General Release,
then the Company will provide the Executive with the same payments and benefits
as specified under Section 3.3.1 hereof, and additionally all stock options,
restricted stock and other equity compensation granted to Executive on or after
the Change in Control shall immediately accelerate vesting as to 100% of the
covered shares.

3.3.3. Definition of Change in Control. For purposes of this Agreement, “Change
in Control” means a change in ownership or control of the Company effected
through any of the following transactions, in one or a series of related
transactions:

(a) a sale of substantially all of the assets of the Company;

 

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(b) a merger or consolidation in which the Company is not the surviving
corporation (other than a merger or consolidation in which shareholders
immediately before the merger or consolidation have, immediately after the
merger or consolidation, equal or greater stock voting power);

(c) a reverse merger in which the Company is the surviving corporation but the
shares of the Company’s common stock outstanding immediately preceding the
merger are converted by virtue of the merger into other property, whether in the
form of securities, cash or otherwise (other than a reverse merger in which
shareholders immediately before the merger have, immediately after the merger,
greater stock voting power); or

(d) any transaction or series of related transactions in which in excess of 50%
of the Company’s voting power is transferred.

3.4. Termination for Death or Disability. If the Executive’s employment by the
Company ceases due to a termination by reason of death or disability as
determined by the Board in its sole discretion and the Executive (or the
Executive’s beneficiaries as the case may be) executes and does not revoke a
General Release, then the Company will provide to the Executive or his
beneficiaries the same payments and benefits as set forth in Section 3.2.1
hereof.

4. Restrictive Covenants. As consideration for all of the payments to be made to
the Executive pursuant to Sections 2, 3, 5, and 6 of this Agreement, as well as
for any equity incentive awards that the Executive may receive from the Company,
the Executive agrees to be bound by the provisions of this Section 4 (the
“Restrictive Covenants”). These Restrictive Covenants will apply without regard
to whether any termination of the Executive’s employment is initiated by the
Company or the Executive, and without regard to the reason for such termination.

4.1. Covenant Not To Compete. The Executive covenants that, during the period
beginning on the Effective Date and ending on the date of the termination of the
Executive’s employment with the Company (the “Restricted Period”), he will not
(except in his capacity as an employee or director of the Company) do any of the
following, directly or indirectly, anywhere in the world:

4.1.1. engage or participate in any business competitive with the Business (as
defined below);

4.1.2. become interested in (as owner, stockholder, lender, partner,
co-venturer, director, officer, employee, agent or consultant) any person, firm,
corporation, association or other entity engaged in any business competitive
with the Business; provided, however, that unless such holdings materially
interfere with the Executive’s performance of his duties hereunder, Executive or
his affiliates may hold up to 4.9% of the outstanding securities of any class of
any publicly-traded securities of any company and up to 10% of the outstanding
securities of any class of any non-publicly traded company and such ownership
shall not constitute a breach of this section 4.1.2;

4.2. Covenant Not To Solicit. The Executive covenants that, during the
Restricted Period and for one year thereafter, he will not (except in his
capacity as an employee or director of the Company) do any of the following,
directly or indirectly, anywhere in the world:

 

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4.2.1. engage in any business, or solicit or call on any customer, supplier,
licensor, licensee, contractor, agent, representative, advisor, strategic
partner, distributor or other person with whom the Company shall have dealt or
any prospective customer, supplier, licensor, licensee, contractor, agent,
representative, advisor, strategic partner, distributor or other person that the
Company shall have identified and solicited at any time during the Executive’s
employment by the Company for a purpose competitive with the Business;

4.2.2. influence or attempt to influence any employee, consultant, customer,
supplier, licensor, licensee, contractor, agent, representative, advisor,
strategic partner, distributor or other person to terminate or modify adversely
to the Company any written or oral agreement, arrangement or course of dealing
with the Company; or

4.2.3. solicit for employment any person who has been employed or retained by
the Company within the 12 months preceding the termination of the Executive’s
employment with the Company for any reason. Notwithstanding the foregoing, the
Executive shall be permitted to solicit for employment his executive assistant
free of the restrictions set forth in this Section 4.2.3.

4.3. Covenant Not To Make Disparaging Statements. For a period of one year
following the date of termination, (i) the Executive agrees not to make or
publish any disparaging statements about the Company or its directors, officers,
agents, employees or representatives, and (ii) the Company agrees not to make or
publish any disparaging statements about the Executive; provided, however, that
the foregoing shall not prohibit at any time (x) the Company from reporting or
commenting regarding the Executive’s business or professional conduct or actions
occurring after the date of termination, or (y) the Executive from commenting
about the business or professional conduct or actions of the Company or its
directors, officers, agents, employees or representatives, occurring after the
date of termination.

4.4. Covenant To Abide By Employment, Confidential Information and Invention
Assignment Agreement. Other than as provided in this Agreement, the Executive
shall continue to abide by the Executive’s Employment, Confidential Information
and Investment Assignment Agreement with the Company.

4.5. Business. For purposes of this Agreement, “Business” means any business
conducted by the Company during the period of the Executive’s employment with
the Company.

4.6. Acknowledgements. The Executive acknowledges that the Restrictive Covenants
are reasonable and necessary to protect the legitimate interests of the Company
and its affiliates and that the duration and geographic scope of the Restrictive
Covenants are reasonable given the nature of this Agreement and the position the
Executive will hold within the Company. The Executive further acknowledges that
the Restrictive Covenants are included herein in order to induce the Company to
continue to employ the Executive pursuant to this Agreement and that the Company
would not have entered into this Agreement in the absence of the Restrictive
Covenants.

 

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4.7. Remedies and Enforcement Upon Breach.

4.7.1. Specific Enforcement. The Executive acknowledges that any breach by him,
willfully or otherwise, of the Restrictive Covenants will cause continuing and
irreparable injury to the Company for which monetary damages would not be an
adequate remedy. The Executive shall not, in any action or proceeding to enforce
any of the provisions of this Agreement, assert the claim or defense that such
an adequate remedy at law exists. In the event of any such breach by the
Executive, the Company shall have the right to enforce the Restrictive Covenants
by seeking injunctive or other relief in any court, without any requirement that
a bond or other security be posted, and this Agreement shall not in any way
limit remedies of law or in equity otherwise available to the Company.

4.7.2. Judicial Modification. If any court determines that any of the
Restrictive Covenants, or any part thereof, is unenforceable because of the
duration or geographical scope of such provision, such court shall have the
power to modify such provision and, in its modified form, such provision shall
then be enforceable.

4.7.3. Accounting. If the Executive breaches any of the Restrictive Covenants,
the Company will have the right and remedy to require the Executive to account
for and pay over to the Company all compensation, profits, monies, accruals,
increments or other benefits derived or received by the Executive as the result
of such breach. This right and remedy will be in addition to, and not in lieu
of, any other rights and remedies available to the Company under law or in
equity.

4.7.4. Enforceability. If any court holds the Restrictive Covenants
unenforceable by reason of their breadth or scope or otherwise, it is the
intention of the parties hereto that such determination not bar or in any way
affect the right of the Company to the relief provided above in the courts of
any other jurisdiction within the geographic scope of such Restrictive
Covenants.

4.7.5. Disclosure of Restrictive Covenants. The Executive agrees to disclose the
existence and terms of the Restrictive Covenants to any employer that the
Executive may work for during the Restricted Period.

5. Change in Control. Immediately upon a Change in Control of the Company, any
equity awards then held by the Executive and not otherwise vested, including the
RSU, shall be fully vested and exercisable as of the date of the Change in
Control.

6. Parachute Payments.

6.1. Certain Additional Payments by the Company. Anything in this Agreement to
the contrary notwithstanding and except as set forth below, in the event it
shall be determined that any Payment would be subject to the excise tax imposed
by Section 4999 of the Code, together with any interest or penalties imposed
with respect to such excise tax (the “Excise Tax”), then the Executive shall be
entitled to receive from the Company an additional payment (the “Gross-Up
Payment”) in an amount such that the net amount of the Payment and the Gross-Up
Payment retained by the Executive after the payment by the Executive of all
Excise Taxes (including any interest or penalties imposed with respect to such
taxes) on the Payment and all federal, state and local income tax, employment
tax and Excise Taxes (including any interest or penalties imposed with respect
to such taxes) on the Gross-Up Payment shall be equal to the “Payment.”

 

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6.2. Determinations. Subject to the provisions of Section 6.3, all
determinations required to be made under this Section 6, including whether and
when a Gross-Up Payment is required and the amount of such Gross-Up Payment and
the assumptions to be utilized in arriving at such determination, shall be made
by the nationally recognized certified public accounting firm used by the
Company immediately prior to the effective date of the Change in Control or, if
such firm declines to serve, such other nationally recognized certified public
accounting firm as may be designated by the Executive (the “Accounting Firm”).
The Accounting Firm shall provide detailed supporting calculations both to the
Company and the Executive within 15 business days of the receipt of notice from
the Executive that there has been a Payment, or such earlier time as is
requested by the Company. All fees and expenses of the Accounting Firm shall be
borne solely by the Company. Any determination by the Accounting Firm shall be
binding upon the Company and the Executive. Subject to Section 6.5 below, any
Gross-Up Payment, as determined pursuant to this Section 6.2, shall be paid by
the Company to the Executive within five days of the receipt of the Accounting
Firm’s determination. For purposes of making the calculations required by this
Section 6, the Accounting Firm may make reasonable assumptions and
approximations concerning applicable taxes and may rely on reasonable,
good-faith interpretations concerning the application of Sections 280G and 4999
of the Code. As a result of the uncertainty in the application of Section 4999
of the Code at the time of the initial determination by the Accounting Firm
hereunder, it is possible that Gross-Up Payments which will not have been made
by the Company should have been made (“Underpayment”), consistent with the
calculations required to be made hereunder. In the event that the Company
exhausts its remedies pursuant to Section 6.3 and the Executive thereafter is
required to make a payment of any Excise Tax, the Accounting Firm shall
determine the amount of the Underpayment that has occurred and any such
Underpayment shall be promptly paid by the Company to or for the benefit of the
Executive.

6.3. Contesting of Gross-Up Payment. The Executive shall notify the Company in
writing of any claim by the Internal Revenue Service that, if successful, would
require the payment by the Company of the Gross-Up Payment. Such notification
shall be given as soon as practicable but no later than ten business days after
the Executive is informed in writing of such claim, and shall apprise the
Company of the nature of such claim and the date on which such claim is
requested to be paid. The Executive shall not pay such claim prior to the
expiration of the 30-day period following the date on which it gives such notice
to the Company (or such shorter period ending on the date that any payment of
taxes with respect to such claim is due). If the Company notifies the Executive
in writing prior to the expiration of such period that it desires to contest
such claim, the Executive shall:

6.3.1. give the Company any information reasonably requested by the Company
relating to such claim;

6.3.2. take such action in connection with contesting such claim as the Company
shall reasonably request in writing from time to time, including, without
limitation, accepting legal representation with respect to such claim by an
attorney expert in such area reasonably selected by the Company;

 

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6.3.3. cooperate with the Company in good faith in order effectively to contest
such claim; and

6.3.4. permit the Company to participate in any proceedings relating to such
claim; provided, however, that the Company shall bear and pay directly all costs
and expenses (including additional interest and penalties) incurred in
connection with such contest and shall indemnify and hold the Executive
harmless, on an after-tax basis, for any Excise Tax or income tax (including
interest and penalties with respect thereto) imposed as a result of such
representation and payment of costs and expenses. Without limitation on the
foregoing provisions of this Section 6.3, the Company shall control all
proceedings taken in connection with such contest and, at its sole option, may
pursue or forgo any and all administrative appeals, proceedings, hearings and
conferences with the taxing authority in respect of such claim and may, at its
sole option, either direct the Executive to pay the tax claimed and sue for a
refund or contest the claim in any permissible manner, and the Executive agrees
to prosecute such contest to a determination before any administrative tribunal,
in a court of initial jurisdiction and in one or more appellate courts, as the
Company shall determine and specify in writing to Executive; provided, however,
that if the Company directs the Executive to pay such claim and sue for a
refund, the Company shall advance the amount of such payment to the Executive,
on an interest-free basis, and shall indemnify and hold the Executive harmless,
on an after-tax basis, from any Excise Tax or income tax (including interest or
penalties with respect thereto) imposed with respect to such advance or with
respect to any imputed income with respect to such advance; and, provided,
further, however, that any extension of the statute of limitations relating to
payment of taxes for the taxable year of the Executive with respect to which
such contested amount is claimed to be due is limited solely to such contested
amount. Furthermore, the Company’s control of the contest shall be limited to
issues with respect to which a Gross-Up Payment would be payable hereunder and
the Executive shall be entitled to settle or contest, as the case may be, any
other issue raised by the Internal Revenue Service or any other taxing
authority.

6.4. Refunds. If, after the receipt by the Executive of an amount advanced by
the Company pursuant to Section 6.3, the Executive becomes entitled to receive
any refund with respect to such claim, the Executive shall (subject to the
Company’s complying with the requirements of Section 6.3) promptly pay to the
Company the amount of such refund (together with any interest paid or credited
thereon after taxes applicable thereto). If, after the receipt by the Executive
of an amount advanced by the Company pursuant to Section 6.3, a determination is
made that the Executive shall not be entitled to any refund with respect to such
claim and the Company does not notify the Executive in writing of its intent to
contest such denial of refund prior to the expiration of 30 days after such
determination, then such advance shall be forgiven and shall not be required to
be repaid and the amount of such advance shall offset, to the extent thereof,
the amount of Gross-Up Payment required to be paid.

6.5. Withholding. Notwithstanding any other provision of this Section 6, the
Company may withhold and pay over to the Internal Revenue Service for the
benefit of the Executive all or any portion of the Gross-Up Payment that it
determines in good faith that it is or may be in the future required to
withhold, and the Executive hereby consents to such withholding.

 

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7. Miscellaneous.

7.1. Prior Agreements. This Agreement shall supersede the Severance Agreement
and any other agreement providing cash severance benefits to the Executive. This
Agreement shall constitute the mutual written consent of the Company and the
Executive (within the meaning of Section 7.7 of the Severance Agreement) to
terminate the Severance Agreement. By executing this Agreement, the Executive
waives any rights the Executive may currently have or have in the future under
the Severance Agreement and any other agreement providing cash severance
benefits to the Executive.

7.2. Code Section 409A. This Agreement shall be interpreted, construed and
administered in a manner that does not cause the Executive to incur federal tax
liability under Section 409A of the Code, and any payment scheduled to be made
hereunder that would otherwise result in adverse tax consequences to the
Executive under Section 409A of the Code shall be delayed to the extent
necessary to avoid such consequences.

7.3. Other Agreements. The Executive represents and warrants to the Company that
there are no restrictions, agreements or understandings whatsoever to which he
is a party that would prevent or make unlawful his execution of this Agreement,
that would be inconsistent or in conflict with this Agreement or the Executive’s
obligations hereunder, or that would otherwise prevent, limit or impair the
performance by the Executive of his duties under this Agreement.

7.4. Successors and Assigns. The Company may assign this Agreement to any
successor to all or substantially all of its assets and business by means of
liquidation, dissolution, merger, consolidation, transfer of assets, or
otherwise. The duties of the Executive hereunder are personal to the Executive
and may not be assigned by him.

7.5. Governing Law. This Agreement shall be governed by and construed in
accordance with the laws of the State of California without regard to the
principles of conflicts of laws.

7.6. Arbitration. Unless otherwise prohibited by law or specified below, all
disputes, claims and causes of action, in law or equity, arising from or
relating to this Agreement or its enforcement, performance, breach, or
interpretation shall be resolved solely and exclusively by final and binding
arbitration held in San Francisco County, California through Judicial
Arbitration & Mediation Services/Endispute (“JAMS”) under the then existing JAMS
arbitration rules. However, nothing in this Section is intended to prevent
either party from obtaining injunctive relief in court to prevent irreparable
harm pending the conclusion of any such arbitration. The Company will pay the
direct costs and expenses of any such arbitration, including the fees and costs
of the arbitrator. Each party in any such arbitration shall be responsible for
its own attorneys’ fees and related costs and necessary disbursements; provided,
however, that in the event one party refuses to arbitrate and the other party
seeks to compel arbitration by court order, if such other party prevails, except
as may be prohibited by law, it shall be entitled to recover reasonable
attorneys’ fees and related costs and necessary disbursements. Pursuant to
California Civil Code Section 1717, each party warrants that it was represented
by counsel in the negotiation and execution of this Agreement, including the
attorneys’ fees provision herein.

 

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7.7. Waivers; Separability. The waiver by either party hereto of any right
hereunder or any failure to perform or breach by the other party hereto shall
not be deemed a waiver of any other right hereunder or any other failure or
breach by the other party hereto, whether of the same or a similar nature or
otherwise. No waiver shall be deemed to have occurred unless set forth in a
writing executed by or on behalf of the waiving party. No such written waiver
shall be deemed a continuing waiver unless specifically stated therein, and each
such waiver shall operate only as to the specific term or condition waived and
shall not constitute a waiver of such term or condition for the future or as to
any act other than that specifically waived. If any provision of this Agreement
shall be declared to be invalid or unenforceable, in whole or in part, such
invalidity or unenforceability shall not affect the remaining provisions hereof
which shall remain in full force and effect.

7.8. Notices. All notices and communications that are required or permitted to
be given hereunder shall be in writing and shall be deemed to have been duly
given when delivered personally or upon mailing by registered or certified mail,
postage prepaid, return receipt requested, as follows:

If to the Company, to:

CV Therapeutics, Inc.

3172 Porter Drive

Palo Alto, CA 94304

Attn: General Counsel

Fax: (650) 858-0390

With a copy to:

Alan C. Mendelson, Esquire

Joseph M. Yaffe, Esquire

Latham & Watkins LLP

135 Commonwealth Drive

Menlo Park, CA 94025

Fax: (650) 463-2600

If to the Executive, to:

Louis G. Lange

At the last residential address known to the Company

With a copy to:

Roger D. Stern

Wilson Sonsini Goodrich & Rosati

650 Page Mill Road Palo Alto, CA 94304

Fax: (650) 493-6811

or to such other address as may be specified in a notice given by one party to
the other party hereunder.

 

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7.9. Entire Agreement; Amendments. This Agreement and the attached exhibits
contain the entire agreement and understanding of the parties hereto relating to
the subject matter hereof, and merges and supersedes all prior and
contemporaneous discussions, agreements and understandings of every nature
relating to the subject matter. This Agreement may not be changed or modified,
except by an Agreement in writing signed by each of the parties hereto.

7.10. Withholding. The Company will withhold from any payments due to the
Executive hereunder, all taxes, FICA or other amounts required to be withheld
pursuant to any applicable law.

7.11. Headings Descriptive. The headings of sections and paragraphs of this
Agreement are inserted for convenience only and shall not in any way affect the
meaning or construction of any provision of this Agreement.

7.12. Counterparts. This Agreement may be executed in multiple counterparts,
each of which will be deemed to be an original, but all of which together will
constitute but one and the same instrument.

[This space left blank intentionally; signature page follows.]

 

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IN WITNESS WHEREOF, the parties hereto have executed this Agreement effective on
the date and year first above written.

 

CV THERAPEUTICS, INC.

/s/ Santo J. Costa

By:   Santo J. Costa Title:   Chairman, Compensation Committee

LOUIS G. LANGE

/s/ Louis G. Lange

 

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Exhibit A

GENERAL RELEASE OF CLAIMS

This General Release of Claims (“Release”) is entered into as of this      day
of                     , 20    , between Louis G. Lange (the “Executive”), and
CV Therapeutics, Inc. (the “Company”) (collectively referred to herein as the
“Parties”), effective eight days after the Executive’s signature (the “Effective
Date”), unless the Executive revokes his acceptance as provided in Paragraph
2(c), below.

WHEREAS, the Executive was an officer of the Company;

WHEREAS, the Executive and the Company entered into an Employment Agreement
effective as of December 22, 2005 (the “Employment Agreement”);

WHEREAS, as a condition of the Executive’s receipt of certain Severance Benefits
described in the Employment Agreement, the Executive is required to execute,
without revocation, this Release;

THEREFORE, in exchange for the good and valuable consideration set forth in the
Employment Agreement, the adequacy of which is specifically acknowledged, the
Executive and the Company hereby agree as follows:

1. General Release of Claims by the Executive.

(a) The Executive, on behalf of himself and his or her executors, heirs,
administrators, representatives and assigns, hereby agrees to release and
forever discharge the Company and all predecessors, successors and their
respective parent corporations, affiliates, related, and/or subsidiary entities,
and all of their past and present investors, directors, shareholders, officers,
general or limited partners, employees, attorneys, agents and representatives,
and the employee benefit plans in which the Executive is or has been a
participant by virtue of his or her employment with the Company (collectively,
the “Company Releasees”), from any and all claims, debts, demands, accounts,
judgments, rights, causes of action, equitable relief, damages, costs, charges,
complaints, obligations, promises, agreements, controversies, suits, expenses,
compensation, responsibility and liability of every kind and character
whatsoever (including attorneys’ fees and costs), whether in law or equity,
known or unknown, asserted or unasserted, suspected or unsuspected
(collectively, “Claims”), which the Executive has or may have had against such
entities based on any events or circumstances arising or occurring on or prior
to the date hereof or on or prior to his termination of employment with the
Company, arising directly or indirectly out of, relating to, or in any other way
involving in any manner whatsoever the Executive’s employment by the Company or
the separation thereof, and any and all claims arising under federal, state, or
local laws relating to employment, including without limitation claims of
wrongful discharge, breach of express or implied contract, fraud,
misrepresentation, defamation, or liability in tort, and claims of any kind that
may be brought in any court or administrative agency including, without
limitation, claims under Title VII of the Civil Rights Act of 1964, as amended,
42 U.S.C. §§ 2000, et seq.; the Americans with Disabilities Act, as amended,
42 U.S.C. § 12101 et seq.; the Rehabilitation Act of 1973, as amended, 29 U.S.C.
§§ 701 et seq.; the Civil Rights Act of 1866, and the Civil Rights Act of 1991;
42 U.S.C. §§ 1981, et seq.; the Age Discrimination in Employment Act, as
amended, 29 U.S.C. §§ 621, et seq.;

 

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the Equal Pay Act, as amended, 29 U.S.C. § 206(d); regulations of the Office of
Federal Contract Compliance, 41 CFR §§ 60, et seq.; the Family and Medical Leave
Act, as amended, 29 U.S.C. § 2601 et seq.; the Fair Labor Standards Act of 1938,
as amended, 29 U.S.C. §§ 201 et seq.; The Executive Retirement Income Security
Act, as amended, 29 U.S.C. §§ 1001 et seq.; and the California Fair Employment
and Housing Act, California Government Code §§ 12940, et seq.

Notwithstanding the generality of the foregoing, the Executive does not release
the following claims:

(i) Claims for unemployment compensation or any state disability insurance
benefits pursuant to the terms of applicable state law;

(ii) Claims for workers’ compensation insurance benefits under the terms of any
worker’s compensation insurance policy or fund of the Company;

(iii) Claims to continued participation in the Company’s group medical, dental,
vision, and life insurance benefit plans pursuant to the terms and conditions of
the federal law known as COBRA;

(iv) Claims for indemnity under the bylaws of the Company, or as provided for by
Delaware or California law;

(v) Claims based on any right Executive may have to enforce the Company’s
executory obligations under the Employment Agreement or agreements related to
stock awards granted to Executive by the Company; and

(vi) Claims Executive may have to vested or earned compensation and benefits;
and

(vii) Claims arising under the Employment Agreement.

(b) THE EXECUTIVE ACKNOWLEDGES THAT HE HAS BEEN ADVISED OF AND IS FAMILIAR WITH
THE PROVISIONS OF CALIFORNIA CIVIL CODE SECTION 1542, WHICH PROVIDES AS FOLLOWS:

“A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW OR
SUSPECT TO EXIST IN HIS OR HER FAVOR AT THE TIME OF EXECUTING THE RELEASE,
WHICH, IF KNOWN BY HIM OR HER, MUST HAVE MATERIALLY AFFECTED HIS OR HER
SETTLEMENT WITH THE DEBTOR.”

BEING AWARE OF SAID CODE SECTION, THE EXECUTIVE HEREBY EXPRESSLY WAIVES ANY
RIGHTS HE MAY HAVE THEREUNDER, AS WELL AS UNDER ANY OTHER STATUTES OR COMMON LAW
PRINCIPLES OF SIMILAR EFFECT.

(c) Older Worker’s Benefit Protection Act.

The Executive agrees and expressly acknowledges that this Release includes a
waiver and release of all claims which he has or may have under the Age
Discrimination in Employment Act

 

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of 1967, as amended, 29 U.S.C. § 621, et seq. (“ADEA”). The following terms and
conditions apply to and are part of the waiver and release of the ADEA claims
under this Release:

(i) This paragraph, and this Release are written in a manner calculated to be
understood by him.

(ii) The waiver and release of claims under the ADEA contained in this Release
does not cover rights or claims that may arise after the date on which he signs
this Release.

(iii) This Release provides for consideration in addition to anything of value
to which he is already entitled.

(iv) The Executive has been advised to consult an attorney before signing this
Agreement.

(v) The Executive has been granted twenty-one (21) days after he is presented
with this Release to decide whether or not to sign this Release. If he executes
this Release prior to the expiration of such period, he does so voluntarily and
after having had the opportunity to consult with an attorney, and hereby waives
the remainder of the twenty-one (21) day period.

(vi) The Executive has the right to revoke this general release within seven (7)
days of signing this Release. In the event he does so, both this Release and the
offer of benefits to him pursuant to Paragraph 6 of the Transition and
Separation Agreement will be null and void in their entirety, and he will not
receive any Severance Benefits.

If he wishes to revoke this Release, the Executive shall deliver written notice
stating his or her intent to revoke this Release to the Company’s Chief
Executive Officer, at the offices of the Company on or before 5:00 p.m. on the
seventh (7th) day after the date on which he signs this Release.

2. No Assignment. The Parties represent and warrant that there has been no
assignment or other transfer of any interest in any Claim that either Party may
have against the other. The Parties agree to indemnify and hold harmless the
aggrieved Party from any liability, claims, demands, damages, costs, expenses
and attorneys’ fees incurred as a result of any person asserting such assignment
or transfer of any right or claims under any such assignment or transfer.
Provided, however, that the preceding sentence shall not apply with respect to a
claim challenging the validity of this general release with respect to a claim
under the Age Discrimination in Employment Act, as amended.

3. No Actions. The Executive represents and warrants that he is not presently
aware of any injury for which he may be eligible for workers’ compensation
benefits. The Executive agrees that if the Executive hereafter commences, joins
in, or in any manner seeks relief through any suit arising out of, based upon,
or relating to any of the Claims released hereunder or in any manner asserts
against the Company Releasees any of the Claims released hereunder, then the
Executive will pay to the Company Releasees against whom such claim(s) is
asserted, in addition to any other damages caused thereby, all attorneys’ fees
incurred by such Company Releasees in defending or otherwise responding to said
suit or Claim. Provided, however, that the Executive shall not be obligated to
pay the Company Releasees’ attorney’s fees to the extent such fees are
attributable to claims under the Age Discrimination in Employment Act or a
challenge to the validity of the release of claims under the Age Discrimination
in Employment Act.

 

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4. Paragraph Headings. The headings of the several paragraphs in this Release
are inserted solely for the convenience of the Parties and are not a part of and
are not intended to govern, limit or aid in the construction of any term or
provision hereof.

5. Notices. All notices, requests and other communications hereunder shall be in
writing and shall be delivered by courier or other means of personal service
(including by means of a nationally recognized courier service or professional
messenger service), or sent by telex or telecopy or mailed first class, postage
prepaid, by certified mail, return receipt requested, in all cases, addressed
to:

If to the Company:

CV Therapeutics, Inc.

3172 Porter Drive

Palo Alto, CA 94304

Fax: (650) 858-0390

Attention: General Counsel

With a copy to:

Alan C. Mendelson, Esquire

Joseph M. Yaffe, Esquire

Latham & Watkins LLP

135 Commonwealth Drive

Menlo Park, CA 94025

Fax: (650) 463-2600

If to Executive:

Louis G. Lange

At the last residential address known to the Company

All notices, requests and other communications shall be deemed given on the date
of actual receipt or delivery as evidenced by written receipt, acknowledgement
or other evidence of actual receipt or delivery to the address. In case of
service by telecopy, a copy of such notice shall be personally delivered or sent
by registered or certified mail, in the manner set forth above, within three
business days thereafter. Any party hereto may from time to time by notice in
writing served as set forth above designate a different address or a different
or additional person to which all such notices or communications thereafter are
to be given.

6. Severability. The invalidity or unenforceability of any provision of this
Release shall not affect the validity or enforceability of any other provision
of this Release, which shall remain in full force and effect.

 

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7. Governing Law. This Release is to be governed by and construed in accordance
with the laws of the State of California applicable to contracts made and to be
performed wholly within such State, and without regard to the conflicts of laws
principles thereof.

8. Counterparts. This Release may be executed in several counterparts, each of
which shall be deemed to be an original but all of which together shall
constitute one and the same instrument.

9. Construction. The language in all parts of this Release shall in all cases be
construed simply, according to its fair meaning, and not strictly for or against
any of the parties hereto. Without limitation, there shall be no presumption
against any party on the ground that such party was responsible for drafting
this Release or any part thereof.

10. Entire Agreement. This Release and the Employment Agreement set forth the
entire agreement of the Parties in respect of the subject matter contained
herein and therein and supersede all prior agreements, promises, covenants,
arrangements, communications, representations or warranties, whether oral or
written, by any officer, employee or representative of any party hereto, and any
prior agreement of the Parties in respect of the subject matter contained
herein.

11. Amendment. No provision of this Release may be modified, waived or
discharged unless such waiver, modification or discharge is agreed to in writing
and signed by Executive and such officer of the Company as may be specifically
designated by the Board of Directors of the Company.

12. Understanding and Authority. The Parties understand and agree that all terms
of this Release are contractual and are not a mere recital, and represent and
warrant that they are competent to covenant and agree as herein provided. The
Parties have carefully read this Release in its entirety; fully understand and
agree to its terms and provisions; and intend and agree that it is final and
binding on all Parties.

IN WITNESS WHEREOF, and intending to be legally bound, the Parties have executed
the foregoing on the dates shown below.

 

EXECUTIVE   CV Therapeutics, Inc. Louis G. Lange     Title:
Dated:                    , 20       Dated:                    , 20    

 

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