Exhibit 10.8

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SECOND AMENDMENT TO

SUPPLY AND DISTRIBUTION AGREEMENT

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This Second Amendment modifies the Supply and Distribution Agreement by and
between Kadmon Pharmaceuticals, LLC, a Pennsylvania Limited Liability Company
(“KADMON”), with its principal place of business at 119 Commonwealth Drive,
Warrendale, PA 15086 and Camber Pharmaceuticals, Inc., a Delaware company
(“CAMBER”), with its principal place of business at 1031 Centennial Avenue,
Piscataway, NJ 08854, effective as of February 23, 2016 and amended on May 20,
2016 (collectively, the “Agreement”).  Capitalized terms not otherwise defined
herein have the meanings ascribed to them in the Agreement. 

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RECITALS

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WHEREAS, KADMON and CAMBER previously entered into the Agreement for the
purposes of marketing, selling and distributing the Products in the Territory;

WHEREAS, CAMBER has Regulatory Approval to manufacture, sell, and distribute the
Products identified in the revised Product Appendix attached hereto, and has,
either directly or through its Affiliates, the capability to manufacture the
Products;

WHEREAS, KADMON wishes to obtain commercial supplies of the Products identified
in the revised Product Appendix attached hereto from CAMBER for distribution by
KADMON in the Territory; and

WHEREAS,  CAMBER desires to appoint KADMON, and KADMON desires to accept such
appointment by CAMBER, as a Distributor for the purposes of marketing, selling
and distributing the Products identified in the revised Product Appendix
attached hereto in the Territory, subject to the terms and conditions of the
Agreement.

NOW, THEREFORE, in consideration of the representations, warranties and
covenants set forth herein, the Parties agree to amend the Agreement as follows:

1.

This Amendment shall become effective the date it is fully executed by both
parties (the “Effective Date”).

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2.

Exhibit A of the Agreement shall be replaced with the revised Exhibit A attached
hereto.

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3.

Exhibit D of the Agreement shall be replaced with the revised Exhibit D attached
hereto.

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4.

To the extent not otherwise changed or affected by this Amendment, both Parties
agree that all terms, conditions, provisions and/or covenants included in the
original Agreement will continue to have the same force and effect intended.

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[signature page to follow]

IN WITNESS WHEREOF, the parties hereto have each caused this Amendment to be
executed by their duly authorized officers.

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﻿

 

KADMON PHARMACEUTICALS, LLC

 

 

 

By:________________________________

Name & Title:  Eva Heyman, Chief Commercial Officer

Date: March 22, 2017

 

 

CAMBER PHARMACEUTICALS, INC.

 

 

 

By:________________________________

Name & Title:

Date:

﻿

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Exhibit A: Product Appendix

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﻿

 

 

 

Product

Dosage

Unit

NDC

Tetrabenazine

12.5MG

112 CT

31722-821-11

Tetrabenazine

25MG

112 CT

31722-822-11

Valganciclovir

450MG

60 CT

31722-832-60

ABACAVIR

300MG

60 CT

31722-557-60

ENTECAVIR

0.5MG

30 CT

31722-833-30

ENTECAVIR

0.5MG

90 CT

31722-833-90

ENTECAVIR

1MG

30 CT

31722-834-30

LAMIVUDINE

100MG

60 CT

31722-752-60

LAMIVUDINE

150MG

60 CT

31722-753-60

LAMIVUDINE

300MG

30 CT

31722-754-30

LAMIVUDINE/

ZIDOVUDINE

150MG/300MG

60 CT

31722-506-60

﻿

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Exhibit D: Pricing

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﻿

 

 

 

 

Product

Dosage

Unit

NDC

Price

Tetrabenazine

12.5MG

112 CT

31722-821-11

$500.00 per unit

Tetrabenazine

25MG

112 CT

31722-822-11

$950.00 per unit

Valganciclovir

450MG

60 CT

31722-832-60

$726.00 per unit

ABACAVIR

300MG

60 CT

31722-557-60

$94.00 per unit

ENTECAVIR

0.5MG

30 CT

31722-833-30

$126.86 per unit

ENTECAVIR

0.5MG

90 CT

31722-833-90

$400.59 per unit

ENTECAVIR

1MG

30 CT

31722-834-30

$126.86 per unit

LAMIVUDINE

100MG

60 CT

31722-752-60

$122.29 per unit

LAMIVUDINE

150MG

60 CT

31722-753-60

$35.09 per unit

LAMIVUDINE

300MG

30 CT

31722-754-30

$35.09 per unit

LAMIVUDINE/

ZIDOVUDINE

150MG/300MG

60 CT

31722-506-60

$46.78 per unit

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