Exhibit 10.5

[OSI LETTERHEAD]

April 1, 2010

David Epstein
Senior Vice President, Oncology Research

Dear David:

It is my pleasure to confirm your promotion to Senior Vice President, Chief
Scientific Officer, Oncology, effective today, of OSI Pharmaceuticals, Inc.
(“OSIP”).  In this position you will now report to me.  The grade for this
position is a 12. Your salary will remain the same.

In addition, in the event that there is a “Change in Control” of OSIP and within
12 months following such Change in Control either (a) your employment is
terminated by OSIP (or a successor) without “Cause” or (b) you terminate your
employment with “Good Reason” (terminations following a Change in Control
described in clause (a) or (b) being referred to herein as a “Severance”),  the
vesting of all unvested equity or equity based awards held by you at the time of
such Severance, including stock options and RSU’s and, for the avoidance of
doubt, any equity,  equity-based awards or other benefits of either OSIP or a
successor into which unvested equity of OSIP held by you at the time of a Change
in Control is converted in connection with the Change in Control, will
accelerate and be immediately exercisable or payable, as the case may be,
immediately prior to such Severance.   This provision supersedes the provisions
regarding the same subject in the agreements evidencing your grants of stock
options and RSU’s made in December 2009.

For purposes of this letter agreement, the terms Change in Control, Cause and
Good Reason (and the defined terms included in such definitions) shall have the
meaning set forth on Appendix A hereto. In the event that any of the payments
referenced herein must be delayed so as to avoid the imposition of additional
taxes upon you pursuant to the operation of Section 409A of the Internal Revenue
Code of 1986, as amended, such payments shall be delayed until the date which is
six months and one day following a Severance.

 
 

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David, I congratulate you on this achievement and trust you will meet the
challenges of your new position with great success.  If you are in agreement
with this letter, please sign both copies of this letter and return one copy to
Amy Sheehan in the enclosed envelope.  One copy is for your records.

Sincerely,

/s/ Colin Goddard

Colin Goddard, Ph.D.
Chief Executive Officer
 
 

Accepted by:
/s/ David Epstein
   
David Epstein
 

Date: _______________________

 
 

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APPENDIX A – APPLICABLE DEFINITIONS

“Affiliate” shall mean, with respect to any individual or entity, any other
individual or entity who, directly or indirectly through one or more
intermediaries, controls, is controlled by or is under common control with, such
individual or entity.

“Board” shall mean the Board of Directors of OSIP.

"Cause" shall mean that you have: (a) willfully and continually failed to
substantially perform, or been willfully grossly negligent in the discharge of,
your duties to OSIP or any of its subsidiaries (in any case, other than by
reason of a disability, physical or mental illness or analogous condition),
which failure or negligence continues for a period of 10 business days after a
written demand for performance is delivered to you by the Board, which
specifically identifies the manner in which the Board believes that you have not
substantially performed, or been grossly negligent in the discharge of, his or
her duties; (b) committed or engaged in an act of theft, embezzlement or fraud,
or committed a willful and material breach of confidentiality with respect to
OSIP or any of its subsidiaries or a willful unauthorized disclosure or use of
inside information, customer lists, trade secrets or other confidential
information of OSIP or any of its subsidiaries; (c) willfully breached a
fiduciary duty, or willfully and materially violated any other duty, law, rule,
regulation or policy of OSIP or any of its subsidiaries; or (d) been convicted
of a felony or a misdemeanor with respect to which fraud or dishonesty is a
material element.  No act or failure to act on your part shall be deemed
"willful" unless done, or omitted to be done, by you not in good faith or
without reasonable belief that your act or failure to act was in the best
interests of OSIP.

A "Change in Control" shall be deemed to mean the first of the following events
to occur after the date hereof:

(a)           The acquisition by any individual, entity or group (within the
meaning of Section 13(d)(3) or 14(d)(2) of the Exchange Act (a "Person")) of
beneficial ownership (within the meaning of Rule 13d-3 promulgated under the
Exchange Act) of 50% or more of either (1) the then-outstanding shares of common
stock of OSIP (the "Outstanding Company Common Stock") or (2) the combined
voting power of the then-outstanding voting securities of OSIP entitled to vote
generally in the election of directors (the "Outstanding Company Voting
Securities"); provided, however, that, for purposes of this clause (a), the
following acquisitions shall not constitute a Change in Control; (A) any
acquisition directly from OSIP, (B) any acquisition by OSIP, (C) any acquisition
by any employee benefit plan (or related trust) sponsored or maintained by OSIP
or any Affiliate of OSIP or a successor, or (D) any acquisition by any entity
pursuant to a transaction that complies with clause (c)(1) or (c)(2) below;

(b)           Individuals who, as of the date hereof, constitute the Board (the
"Incumbent Board") cease for any reason to constitute at least a majority of the
Board; provided, however, that any individual becoming a director subsequent to
the date hereof whose election, or nomination for election by OSIP's
shareholders, was approved by a vote of at least two-thirds of

 
 

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the directors then comprising the Incumbent Board shall be considered as though
such individual were a member of the Incumbent Board, but excluding, for this
purpose, any such individual whose initial assumption of office occurs as a
result of an actual or threatened election contest with respect to the election
or removal of directors or other actual or threatened solicitation of proxies or
consents by or on behalf of a Person other than the Board;

(c)           The consummation of a merger or consolidation of OSIP or any
direct or indirect subsidiary of OSIP with any other corporation, other than (1)
a merger or consolidation which results in the directors of OSIP immediately
prior to such merger or consolidation continuing to constitute at least a
majority of the board of directors of OSIP, the surviving entity or any parent
thereof or (2) a merger or consolidation effected to implement a
recapitalization of OSIP (or similar transaction) in which no Person acquires
beneficial ownership, directly or indirectly, of securities of OSIP (not
including in the securities beneficially owned by such Person any securities
acquired directly from OSIP) representing 50% or more of the Outstanding Company
Common Stock or the Outstanding Company Voting Securities; or

(d)           Shareholders of OSIP approve a plan of complete liquidation or
dissolution of OSIP or there is consummated an agreement for the sale or
disposition by OSIP of all or substantially all of OSIP 's assets, other than a
sale or disposition by OSIP of all or substantially all of OSIP 's assets to an
entity, at least 50% of the combined voting power of the voting securities of
which are owned by shareholders of OSIP in substantially the same proportions as
their ownership of OSIP immediately prior to such sale.

“Exchange Act” shall mean the Securities Exchange Act of 1934, as amended.

“Good Reason” shall mean (i) a material adverse alteration in the nature or
status of your responsibilities with OSIP or any subsidiary thereof from those
in effect immediately prior to the Change in Control, (ii) a reduction in your
salary or target bonus opportunity from those in effect immediately prior to the
Change in Control, or (iii) a relocation of your principal place of business of
more than 35 miles; provided that the relocation of your work location to
Ardsley, New York which is planned as of the date hereof shall not constitute
Good Reason hereunder.

 

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