CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT (INDICATED BY
ASTERISKS) HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT.

Exhibit 10.1

 

AMENDMENT TO

ASSET PURCHASE AGREEMENT

 

This Amendment (this "Amendment"), dated as of March 21, 2018, is entered into
by and between Evoke Pharma, Inc., a Delaware corporation ("Purchaser"), and
Mallinckrodt ARD Inc. (formerly known as Questcor Pharmaceuticals, Inc.), a
California corporation ("Seller").

 

WHEREAS, the parties entered into that certain Asset Purchase Agreement, dated
as of June 1, 2007 (the "Asset Purchase Agreement"); and

 

WHEREAS, the parties desire to amend the Asset Purchase Agreement in accordance
herewith.

 

NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency
of which are hereby acknowledged, it is hereby agreed as follows:

 

1.Amendment to Agreement. Section 3.3 of the Asset Purchase Agreement is hereby
amended and restated in its entirety as follows:

 

"3.3Milestone Payments. In addition, Purchaser shall pay Seller non-refundable
milestone payments within thirty (30) days of achievement of the following
events specified in Sections 3.3(a), (d), (e), (f) and (g), and on the one-year
anniversary of achievement of the following event specified in Section 3.3(b)
(collectively, the "Milestone Payments"):

 

(a)$500,000 (five hundred thousand dollars) upon initiation of the first patient
dosing in a Phase III clinical trial in the United States, the principal purpose
of which is to establish efficacy and safety of one or more particular doses in
patients being studied as required in 21 C.F.R. §312, such that positive results
would support the filing of the Evoke NDA;

 

(b)$5,000,000 (five million dollars) upon the FDA's approval of an NDA filing by
Purchaser or its Affiliate for the Product (the " Evoke NOA");

 

 

(c)

Reserved.

 

(d)

[***] ([***] dollars) [***];

 

 

(e)[***] ([***] dollars) [***];

 

(f)

[***] ([***] dollars) [***];

 

 

(g)

[***] ([***] dollars) [***];

 

 

For the avoidance of doubt, each of the payments under Sect ions 3.3(a), (b),
(d), (e), (f) and (g) shall be due, if at all, only once upon the first such
applicable [***], up to an aggregate maximum of $52,500,000 (fifty-two million
five hundred thousand dollars) and no additional milestones are due upon
subsequent such [***].

 

 

2.

Miscellaneous.

 

(a)No Other Amendment. Except for the matters set forth in this Amendment, all
other terms of the Asset Purchase Agreement shall remain unchanged and in full
force and effect.

 

--------------------------------------------------------------------------------

 

 

(b)Governing Law. This Amendment shall be governed by and construed in
accordance with the laws of the state of California, without regard to the
conflict of law principles thereof.

 

(c)Counterparts. This Amendment may be executed in on or more counterparts, all
of which shall be considered one and the same agreement and shall become
effective when one or more counterparts have been signed by each of the parties
and delivered to the other parties, it being understood that all parties not
sign the same counterpart.

 

             IN WITNESS WHEREOF, the parties hereto have caused this Amendment
to be signed by their respective representatives thereunto duly authorized, all
as of the date first written above.

EVOKE PHARMA, INC.

 

By:  /s/ David A. Gonyer

          Name:  David A. Gonyer

       Title:    President & CEO

 

 

MALLINCKRODT ARD INC.

 

By:  /s/ Kathleen A. Schaefer

       Name:  Kathleen A. Schaefer

       Title:    President