Exhibit 10.16

--------------------------------------------------------------------------------

--------------------------------------------------------------------------------

Sponsored Research Agreement

AMENDMENT 1

This Amendment is made this 18th day of July, 2014, between the University of
North Texas Health Science Center (“Institution”), with an address at 3500 Camp
Bowie Boulevard, Fort Worth, Texas 76107, and SignPath Pharmaceuticals, Inc.
(“Sponsor”), with an address at 1375 California Road, Quakertown, PA 18951 to
the Sponsored Research Agreement effective August 1, 2013 (the “Agreement”).

WHEREAS, the parties desire to amend certain terms and conditions set forth in
the Agreement.

NOW, THEREFORE, in consideration of the premises and of the promises and mutual
covenants contained herein, and intending to be legally bound hereby, the
parties agree as follows:

1.           The terms of this Agreement, as indicated in Section 3.1 of the
Agreement, shall be extended, and the Agreement shall terminate on October 30,
2014, unless otherwise extended by mutual written agreement of both parties.

2.           Institution will use its own facilities and its reasonable best
efforts to conduct the research program described in Attachment A-1 (“Research
Program”), attached hereto and incorporated herein as an addendum to the
original Attachment A to the Agreement, under the direction of Dr. Jamboor
Vishwanatha or his successor, as mutually agreed to by the parties.

3.           As consideration for Institution’s performance, Sponsor will pay
the Institution a sum of $39,420.00 in equal monthly payments of $13,140.00,
which shall be due on the first of each month during the term of the Agreement,
with the first payment due on August 1, 2014.

4.           All other terms of the original Agreement shall remain in full
force and effect.

This Amendment may be executed in one or more counterparts by the parties by
signature of a person having authority to bind the party, which may be by fax,
by electronic mail in “portable document format” (“.pdf”), or by any other
electronic means intended to preserve the original graphic and pictorial
appearance of the Amendment, shall have the same effect as physical delivery of
the paper document bearing the original signature and all of which will
constitute but one and the same Amendment.

IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be signed
as of the date set forth above.

Sponsor
 
 
By:           /s/ Lawrence Helson 
University of North Texas Health
Science Center
 
 
By:  /s/ LeAnn S. Forsberg 
 
LeAnn S. Forsberg
Assistant VP for Research Administration
 
Date:                        21 July 2014 
 
Date:   7/25/2014 
 
 
Read and Understood:
 
 
By:           /s/ Jamboor Vishwanatha 
Principal Investigator
 
 
Date:          7/25/2014                                

 
 

--------------------------------------------------------------------------------

 
 
Attachment A-1
 
(Research Program Addendum)
 
SignPath SRA Extension (August 1, 2014 to October 30, 2014)
 
Work Plan:
 
Aim 1)
Tumor study with ATCC CRL5935 cells with 4 arms (liposome only, crizotinib,
liposome and curcumin, untreated control).  Tumor study will be eight (8) weeks
(plus four (4) weeks for tumor to develop).

 
Aim 2)
Complete the immunological and molecular studies on the 8-week lung cancer
xenograft study conducted under the SRA for 2013-14.  Prepare a manuscript on
the cancer xenograft study combining the data from aim 1 above, PK study
(external) and UNTHSC data.

 
Aim 3)
Assistance to SamiLabs for Scale up of Curcumin-ER:  While Dr. Rajendran will be
here for 2-3 days in July, he will need to work with us for troubleshooting when
he returns to SamiLabs.  We expect that the next three (3) months will be needed
for Dr. Rajendran to come up to speed on the Curcumin-ER production.

 
 
Budget:

 
Personnel
         
Salary (3 months)
  $ 13,000.00    
Fringe benefits
  $ 3,500.00    
 Personnel Status
  $ 16,500.00              
Supplies
Purchase of CRL 5935 from ATCC
  $ 500.00    
Chemicals and biochemical
  $ 2,000.00    
Cell culture supplies
  $ 2,000.00    
Disposable labware
  $ 1,000.00    
Xenografts (animals, shipping, housing)
  $ 5,000.00                
Supplies Subtotal
  $ 10,500.00    
                   Total direct charges
  $ 27,000.00    
        Institutional overhead (F&A - 46%)
  $ 12,420.00    
Total project costs
  $ 39,420.00  

 

--------------------------------------------------------------------------------