EXHIBIT 10.10

Pharma Services Holding, Inc.
c/o One Equity Partners
230 Park Avenue, 18th Floor
New York, New York 10022

October 30, 2003

Oppel Greeff
111 Beaver Dam Run
Durham, NC 27703

Re: Opportunity to Purchase Shares

Dear Oppel:

As you know, on September 25, 2003, Quintiles Transnational Corp. (“Quintiles”),
became an indirect wholly-owned subsidiary of Pharma Services Holding, Inc. (the
“Company”). We are pleased to offer you the opportunity to purchase shares of
common stock (“Shares”) of the “Company” pursuant to the Company’s Stock
Incentive Plan (the “Plan”) and on the terms and conditions set forth below.

1.   Number of Shares. You will have the opportunity to purchase up to 450,000
Shares.   2.   Purchase Price. The purchase price per Share is $0.2438, for a
total of $109,710 if you purchase all of the Shares, payable by check to the
Company.   3.   Vesting. Your Shares when issued will be “Unvested Shares” (as
defined in the Plan) and will become “Vested Shares” (as defined in the Plan) as
to 20% of the total number awarded on the 25th day of each September, beginning
September 25, 2004 and ending September 25, 2008, provided (i) all Shares will
become Vested Shares upon a “Sale of the Company”, as defined in the Plan, and
the Committee will not exercise its discretion to provide otherwise, (ii) all
Shares will become Vested Shares upon your termination of employment by reason
of your death or pursuant to Section 4.3(ii) of your Executive Employment
Agreement (physical or mental inability to perform), and (iii) upon your
termination of employment under circumstances entitling you to severance
benefits pursuant to Section 5.2 of your Executive Employment Agreement, such
number of Unvested Shares shall become Vested Shares as is equal to the total
number of Shares set forth in paragraph 1 above multiplied by the “vesting
percentage”, as defined below. In no event will any Unvested Shares become
Vested Shares following your termination of employment with the Company and its
subsidiaries for any reason (after taking into account any vesting that occurs
upon termination of employment pursuant to clauses (ii) and (iii) of the
preceding sentence). For purposes of the foregoing, “vesting percentage” means
the 20% multiplied by a fraction, the numerator of which is the

 

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    number of days that have elapsed from the 25th day of September that
immediately precedes the date of your termination of employment through the date
of such termination, and the denominator of which is 365, provided that if the
date of your termination of employment falls on the 25th day of any September,
the vesting percentage shall be zero.   4.   Repurchase Right; Restrictions on
Shares. Upon your termination of employment with the Company and its
subsidiaries for any reason, the Company and certain other persons may, but are
not obligated to, repurchase your Shares. As further described in Section 8 of
the Plan, the repurchase price to be paid by the Company depends upon whether
the Shares are Unvested Shares or Vested Shares, and the circumstances of your
termination. Generally, Unvested Shares may be repurchased for the price you
paid for them, and Vested Shares may be repurchased for their “Fair Market
Value”, as defined in the Plan, but under certain circumstances described in the
Plan, even your Vested Shares may be repurchased for the price you paid for
them. Also, as further described in Section 8 of the Plan, the Shares are
generally nontransferable prior to a Sale of the Company or “Qualified Public
Offering” (as defined in the Plan), the Company has the right to require that
you participate in a Sale of the Company (a “Drag-Along Right”), and your right
to vote with respect to the election of directors of the Company may be
restricted. For purposes of Section 8(c)(ii) of the Plan (Repurchase Right), in
making a good faith determination of “Fair Market Value”, the Committee will
take into account the most recent outside event pursuant to which a value of a
Share can be implied (including, without limitation, an equity issuance, stock
option grant or valuation by an appraisal firm, investment bank or similar
organization), provided that if no such event has occurred within the preceding
12 months, the Committee shall obtain a new valuation by an appraisal firm,
investment bank or similar organization, and shall take such valuation into
account in determining Fair Market Value. For purposes of the proviso contained
in Section 8(c)(ii) of the Plan, clause (x) thereof shall not apply, and clause
(z) shall apply only if the breach referred to therein is material.   5.  
Taxes. A separate information statement describing the tax considerations
relating to your purchase of Shares will be provided to you.   6.  
Representations.

       (a) Authority. You have the requisite power, authority and capacity to
execute this Agreement and to perform your obligations under this Agreement and
to consummate the transactions contemplated hereby. The Acceptance has been duly
and validly executed and delivered by you and constitutes your legal, valid and
binding obligation, enforceable against you in accordance with its terms, except
to the extent that such validly binding effect and enforceability may be limited
by applicable bankruptcy, reorganization, insolvency, moratorium and other laws
relating to or affecting creditors’ rights generally.

       (b) Brokers. No Person is entitled to any broker’s, finder’s, financial
adviser’s or other similar fee or commission in connection with the transactions
contemplated hereby based upon any action taken by you.

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       (c) Shares Unregistered; Accredited Investor. You acknowledge that (i)
the offer and sale of the Shares has not been registered under applicable
securities laws; (ii) the Shares being purchased by you must be held
indefinitely; (iii) there is no established market for the Shares and it is not
anticipated that there will be any such market for the Shares in the foreseeable
future; (iv) you are an “accredited investor” under Rule 501(a) of the
Securities Act of 1933; (v) your knowledge and experience in financial and
business matters are such that you are capable of evaluating the merits and
risks of your investment in the Shares, or you have been advised by a
representative (not affiliated with the Company) possessing such knowledge and
experience; (vi) you and your representatives, including your professional,
financial, tax and other advisors, if any, have carefully considered your
proposed investment in the Shares, and you understand and have taken cognizance
of (or have been advised by your representatives as to) the risk factors related
to the acquisition of such Shares, and no representations or warranties have
been made to you or your representatives concerning the Shares, the Company or
the Company’s business, operations, financial condition or prospects or other
matters; (vii) in making your decision to purchase the Shares, you have relied
upon independent investigations made by you and, to the extent believed by you
to be appropriate, your representatives, including your professional, financial,
tax and other advisors, if any; (viii) you and your representatives have been
given the opportunity to request to examine all documents of, and to ask
questions of, and to receive answers from, the Company and its representatives
concerning the terms and conditions of the acquisition of the Shares and to
obtain any additional information which you or your representatives deem
necessary; (ix) you are acquiring the Shares for the purpose of investment and
not with a view to, or for resale in connection with, the distribution thereof,
and not with any present intention of distributing such Shares and you have no
present plan or intention to sell any of the Shares; and (x) the Company is
allowing you to acquire the Shares in reliance upon these representations and
warranties.

7.   Subject to Plan. The opportunity to purchase the Shares is being made to
you pursuant to the Plan, a copy of which is attached, and such purchase,
holding and transfer of the Shares is subject to the terms of the Plan in all
respects.   8.   Conditions. Our offer and your acceptance of our to purchase
Shares is conditional upon your execution of an amendment to your Executive
Employment Agreement in the form attached as Exhibit A no later than
November 17, 2003.   9.   Acknowledgement. You acknowledge: (i) that the Plan is
discretionary in nature and may be suspended or terminated by the Company at any
time; (ii) that this grant of the opportunity to purchase Shares is a one-time
benefit, which does not create any contractual or other right to receive future
awards under the Plan, or benefits in lieu of awards; (iii) that all
determinations with respect to any such future grants, including, but not
limited to, the times when awards shall be granted, the number of shares subject
to each award, the exercise or purchase price, and the time or times when each
award shall vest, will be at the sole discretion of the Committee; (iv) that
your participation in the Plan shall not create a right to further employment
with the Company or its affiliates and shall not interfere with the Company’s,
its affiliates’ or your ability to terminate your employment relationship at any
time with or

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    without cause; (v) that your participation in the Plan is voluntary; (vi)
that the value of this award is an extraordinary item of compensation which is
outside the scope of your employment contract, if any; and (vii) that award is
not part of normal or expected compensation for purposes of calculating any
severance, resignation, redundancy, end of service payments, bonuses,
long-service awards, pension or retirement benefits or similar payments.   10.  
Employee Data Privacy. As a condition of the grant of this opportunity to
purchase Shares, you consent to the collection, use and transfer of personal
data as described in this paragraph 10. You understand that the Company and its
Affiliates hold certain personal information about you including, but not
limited to, your name, home address and telephone number, date of birth, social
security number, salary, nationality, job title, shares of common stock or
directorships held in the Company, details of all Options or other entitlement
to shares of common stock awarded, cancelled, exercised, vested, unvested or
outstanding in your favor, for the purpose of managing and administering the
Plan (“Data”). You further understand that the Company and/or its Affiliates
will transfer Data amongst themselves as necessary for the purposes of
implementation, administration and management of your participation in the Plan,
and that the Company and/or any of its Affiliates may each further transfer Data
to any third parties assisting the Company in the implementation, administration
and management of the Plan. You understand that these recipients may be located
in your country of residence or elsewhere, such as the United States. You
authorize them to receive, possess, use, retain and transfer Data in electronic
or other form, for the purposes of implementing, administering and managing your
participation in the Plan, including any requisite transfer of such Data as may
be required for the administration of the Plan and/or the subsequent holding
shares of common stock on your behalf to a broker or other third party with whom
the shares acquired on exercise may be deposited. You understand that he or she
may, at any time, view the Data, require any necessary amendments to it or
withdraw the consent herein in writing by contacting the local human resources
representative.

Please indicate the number of Shares you wish to purchase on the Acceptance
below. Please return a signed copy of the Acceptance, along with a check for the
purchase price ($0.2438 per Share) made payable to Pharma Services Holding,
Inc., to Gary Rothstein, Esq., Morgan Lewis & Bockius, LLP, 101 Park Avenue, New
York, NY 10178. Your Acceptance and payment must be received no later than
November 17, 2003.

  Sincerely yours,       PHARMA SERVICES HOLDING, INC.

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ACCEPTANCE OF OFFER
TO PURCHASE COMMON SHARES OF PHARMA SERVICES HOLDING, INC.

I, Oppel Greeff hereby accept the offer made to me by Pharma Services Holding,
Inc. (“Pharma”) to purchase 450,000 shares of common stock of Pharma at a price
per share of $0.2438 pursuant to and in accordance with the terms of a letter to
me from Pharma dated October 30, 2003, and enclose a check for $109,710.

      /s/ Oppel Greeff   12/06/03

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Oppel Greeff         Date

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