AMENDMENT TO EMPLOYMENT AGREEMENT

AMENDMENT (the “Amendment”) dated October 19, 2005 to the Employment Agreement
dated as of April 6, 2004 (the “Shailubhai Employment Agreement”) by and between
Synergy Pharmaceuticals Inc., a Delaware corporation (the “Company”), and Kunwar
Shailubhai, an individual (the “Executive”).

WHEREAS, the parties desire to amend the Shailubhai Employment Agreement to
increase the amount of compensation to be paid upon termination;

NOW THEREFORE, in consideration of the foregoing facts and mutual agreements set
forth below, the parties, intending to be legally bound, agree as follows:

1.         Amendment to Shailubhai Employment Agreement.  The Shailubhai
Employment Agreement is hereby amended as follows:

1.1         Section 4.3 is hereby amended by changing thirty (30) days to ninety
(90) days in the third sentence of Section 4.3.

2.         Ratification.  The Shailubhai Employment Agreement is ratified and
confirmed and shall continue in full force and effect as amended hereby.

3.         Headings and Captions.  The headings and captions of the various
subdivisions of this Amendment are for convenience of reference only and shall
in no way modify or affect the meaning or construction of any of the terms or
provisions hereof.

4.         Counterparts.  This Amendment may be executed in two or more
counterparts, and by different parties hereto on separate counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument. This Agreement may be executed by facsimile with
original signatures to follow.

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IN WITNESS WHEREOF, the parties hereto have executed this Amendment or caused
this Amendment to be executed by their duly authorized representatives as of the
date first above written.
 

       
SYNERGY PHARMACEUTICALS, INC.
 
   
   
    By:   /s/ Gary S. Jacob  

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Gary S. Jacob
Chairman of the Board
          /s/ Kunwar Shailubhai  

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  Kunwar Shailubhai