Exhibit 10.41

 

                                November 22, 2004

 

BY FACSIMILE AND EXPRESS MAIL

CONFIDENTIAL

Peter A. Lankau

President

Endo Pharmaceuticals Inc.

100 Painters Drive

Chadds Ford, PA 19317

 

Re: Amendment 2 to Development, Commercialization and Supply License Agreement

 

Dear Peter:

 

Reference is made to the Development, Commercialization and Supply License
Agreement between Endo Pharmaceuticals Inc. (“Endo”) and DURECT Corporation
(“DURECT”) effective November 8, 2002, as amended effective January 28, 2004
(“Agreement”). Effective on the date written above, Endo and DURECT hereby agree
to amend the Agreement as follows:

 

  1. Amendment to Section 4.6(a). Section 4.6(a) of the Agreement shall be
amended to replace each instance of “January 1, 2005” with “January 1, 2006”.

 

  2. Amendment to Section 4.6(c). Section 4.6(c) of the Agreement shall be
amended to replace each instance of “January 1, 2005” with “January 1, 2006”.

 

  3. Amendment to Section 13.3(e). Section 13.3(e) of the Agreement shall be
amended to replace “January 1, 2005” with “January 1, 2006” and “January 31,
2005” with “January 31, 2006”.

 

Except as set forth above, all other terms of the Agreement shall remain the
same. Please sign below to indicate Endo’s agreement to the foregoing.

 

Very truly yours,

/s/ James E. Brown

--------------------------------------------------------------------------------

James E. Brown

President and CEO

 

AGREED TO BY ENDO:

By:

 

/s/ Peter A. Lankau

--------------------------------------------------------------------------------

   

Peter A. Lankau

   

President

 

Date: Nov. 22, 2004