Exhibit 10.12C

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2nd Amendment

AMENDMENT TO LEASE – EXPANSION

THIS AMENDMENT is executed at Salt Lake City, Utah between Salt Lake Research
Park Associates, a New Mexico Limited Partnership, by BGK Realty, Inc., a
Delaware Corporation, as General Partner, Landlord, and NPS Pharmaceuticals,
Inc.. a Delaware Corporation., Tenant, for the premises located at 420 Chipeta
Way, Suites 140, 200 & 202 Salt Lake City, Utah 84108.

Landlord and Tenant being parties to that certain Lease dated June 3, 1994 and
as amended May 14, 1995 hereby express their mutual desire and intent to
increase the rentable area of the Leased Premises by 10,570 square feet
(hereafter referred to as “Expansion Space”) effective July 1, 1997 and amend by
this writing those terms, covenants as hereinafter provided.

  Section 2.  Leased Premises and Rentable Area. This Section shall be adjusted
to provide as follows: That portion of the 1st and 2nd floors of the building
more fully shown on the Floor Plan attached hereto as Exhibit “A” – Expansion
Space.The Rentable Area of the Premises shall hereafter mean: approximately
44,187 square feet.

      Section 4. Term. The term for the Expansion Space shall be coterminous
with the existing Lease.

      Section 5. Rent. This Section shall be adjusted to provide as follows: The
Rent for the Expansion Space shall be One Hundred Ten Thousand Nine Hundred
Eighty-Eight and No/100 Dollars ($110,988.00) per annum, payable in monthly
installments in the amount of Nine Thousand Two Hundred Forty-Nine and No/100
Dollars ($9,249.00) in lawful money of the United States.

      Section 7. Operating Expenses. Tenant's Proportionate Share shall be
adjusted to 39.4%.     Except as modified herein, all terms and conditions of
the Office Lease shall remain in full force and effect.

      Landlord:   Tenant:       Salt Lake Research Park Associates, a New Mexico
Limited Partnership   NPS Pharmaceuticals, Inc., a Delaware Corporation      
By:     BGK Realty, Inc.
    Its:     General Partner           By:     /s/ Cheryl S. Willoughby  
By:     /s/ Robert K. [Illegible] Title:  Senior Vice President   Title:  Vice
President, Finance Execution Date: September 11, 1996   Execution
Date: September 4, 1996

 

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