THIRD AMENDMENT TO
STANDARD MULTI-TENANT OFFICE LEASE — GROSS

THIS THIRD AMENDMENT TO STANDARD MULTI-TENANT OFFICE LEASE – GROSS dated as of
December 10, 2009 (this “Third Amendment”) is entered into by and between
WESTCORE MESA VIEW, LLC, a Delaware limited liability company and DD MESA VIEW,
LLC, a California limited liability company (collectively, “Lessor”), and
ADVENTRX PHARMACEUTICALS, INC., a Delaware Corporation (“Lessee”), with
reference to the following:

R E C I T A L S

WHEREAS, George V. Casey and Ellen M. Casey, Trustees of the Casey Family Trust,
dated June 22, 1998 (“Original Lessor”), and Lessee entered into that certain
Standard Multi-Tenant Office Lease — Gross dated June 3, 2004 (the “Original
Lease”), as amended by that certain First Amendment to Original Lease, dated
May 12, 2005 (the “First Amendment”), and that certain Second Amendment to
Original Lease, dated July 22, 2009 (the “Second Amendment”; the Original Lease,
the First Amendment and the Second Amendment are sometimes collectively referred
to herein as the “Lease”) for the lease of certain premises (the “Premises”),
currently consisting of approximately 3,173 rentable square feet commonly known
currently as Suite 100 (previously known as Suite 102), located at 6725 Mesa
Ridge Road, San Diego , California (the “Building”). Lessor is the
successor-in-interest to Original Lessor under the Original Lease. All
capitalized terms used herein and not otherwise defined herein shall have the
meanings ascribed to such terms in the Lease.

WHEREAS, Lessor and Lessee desire by this Third Amendment to amend the Lease in
order to, among other things, (a) extend the term of the Lease for an additional
eight (8) month period; (b) provide for the Base Rent to be paid by Lessee for
the Premises during the Extension Term (as defined below); and (c) further
amend, modify and supplement the Lease as set forth herein.

NOW, THEREFORE, in consideration of the promises set forth herein and for other
good and valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, Lessor and Lessee hereby agree as follows:

1. Recitals. The Recitals set forth above are incorporated herein as though set
forth in full herein.

2. Extension of Term. Lessor and Lessee acknowledge that the term of the Lease
expires according to its terms on May 31, 2010 (the “Old Expiration Date”).
Notwithstanding anything to the contrary contained in the Lease, Lessor and
Lessee agree the Expiration Date of the Lease shall be extended such that the
Lease shall terminate on January 31, 2011 (the “New Expiration Date”), unless
sooner terminated in accordance with the terms of the Lease. The period from
June 1, 2010 through the New Expiration Date shall be referred to herein as the
“Extension Term.”

3. Base Rent During the Extension Term. Notwithstanding anything in the Lease to
the contrary and in addition to paying all other amounts due under the Lease,
including without limitation all Additional Rent, Lessee shall pay Monthly Base
Rent for the Premises during the Extension Term in the amount of Four Thousand
Four Hundred Forty Two and 20/100 Dollars ($4,442.20).

4. Condition of the Premises. Lessee acknowledges that it has been and continues
to be in possession of the Premises, is familiar with the condition of the
Premises and accepts the Premises in its presently existing, “as is” condition,
with all faults and without representation, warranty or improvements by Lessor
of any kind whatsoever.

5. Security Deposit. The existing Security Deposit held by Lessor at the Old
Expiration Date will be $0.00. Concurrently with Lessee’s execution of this
Third Amendment, Lessee shall deposit $2,221.10 to the existing deposit held by
Lessor under the Lease for a total Security Deposit hereunder of $2,221.10 to be
held in accordance with the terms of Section 5 of the Original Lease.

6. Business Hours for the Building. Section 1.12 of the Original Lease shall be
amended as follows: 8 a.m. to 6 p.m. Mondays through Fridays (except Building
Holidays). “Building Holidays” shall mean the dates of observation of New Year’s
Day, President’s Day, Memorial Day, Independence Day, Labor Day, Thanksgiving
Day, and Christmas Day.

7. Utility Bills. Upon Lessor’s request, Lessee shall deliver to Lessor copies
of all bills for separately metered utilities supplied to the Premises for the
past twelve (12) month period within thirty (30) days of Lessor’s request.

8. Estoppel. Lessee hereby certifies and acknowledges, that as of the date
hereof (a) Lessor is not in default in any respect under the Lease, (b) Lessee
does not have any defenses to its obligations under the Lease, (c) Lessor is
holding a security deposit in the amount of $15,547.70 under the Lease to be
used for Monthly Base Rent payments pursuant to the Second Amendment, and
(d) there are no offsets against rent payable under the Lease. Lessee
acknowledges and agrees that: (i) the representations herein set forth
constitute a material consideration to Lessor in entering into this Third
Amendment; (ii) such representations are being made by Lessee for purposes of
inducing Lessor to enter into this Third Amendment; and (iii) Lessor is relying
on such representations in entering into this Third Amendment.

9. Brokers. Lessee hereby represents and warrants to Lessor that Lessee has not
entered into any agreement or taken any other action which might result in any
obligation on the part of Lessor to pay any brokerage commission, finder’s fee
or other compensation with respect to this Third Amendment, and Lessee agrees to
indemnify and hold Lessor harmless from and against any losses, damages, costs
or expenses (including without limitation, attorneys’ fees) incurred by Lessor
by reason of any breach or inaccuracy of such representation or warranty.

10. Ratification. Except as otherwise specifically herein amended, the Original
Lease is and shall remain in full force and effect according to the terms
thereof. In the event of any conflict between the Lease and this Third
Amendment, this Third Amendment shall control.

11. Attorneys’ Fees. Should either party institute any action or proceeding to
enforce or interpret this Third Amendment or any provision thereof, for damages
by reason of any alleged breach of this Third Amendment or of any provision
hereof, or for a declaration of rights hereunder, the prevailing party in any
such action or proceeding shall be entitled to receive from the other party all
cost and expenses, including actual attorneys’ and other fees, reasonably
incurred in good faith by the prevailing party in connection with such action or
proceeding. The term “attorneys’ and other fees” shall mean and include
attorneys’ fees, accountants’ fees, and any and all consultants’ and other
similar fees incurred in connection with the action or proceeding and
preparations therefore. The term “action or proceeding” shall mean and include
actions, proceedings, suits, arbitrations, appeals and other similar
proceedings.

12. Submission. Submission of this Third Amendment by Lessor to Lessee for
examination and/or execution shall not in any manner bind Lessor and no
obligations on Lessor shall arise under this Third Amendment unless and until
this Third Amendment is fully signed and delivered by Lessor and Lessee.

13. Counterparts. This Third Amendment may be executed in several counterparts,
each of which shall be deemed an original, but all of which together shall
constitute one and the same agreement.

[SIGNATURES ON NEXT PAGE]

IN WITNESS WHEREOF, this Third Amendment has been executed by the parties as of
the date first referenced above.

“Lessor”

WESTCORE MESA VIEW, LLC,
a Delaware limited liability company

      By:  
MRB Manager, LLC,
a Delaware limited liability company,
its Manager
   
By: /s/ Don Ankeny
   
 
   
Don Ankeny
Authorized Signatory

    DD MESA VIEW LLC,

a California limited liability company

      By:  
MRB Manager, LLC,
a Delaware limited liability company,
its Manager
   
By: /s/ Don Ankeny
   
 
   
Don Ankeny
Authorized Signatory

    “Lessee”

ADVENTRX PHARMACEUTICALS, INC,
a Delaware Corporation

By: /s/ Patrick Keran
Patrick Keran
General Counsel and Vice President of Legal