Exhibit 10.2

[NAME]
[ADDRESS]
[ADDRESS]

[DATE]

Dear [ ],
This letter amends and restates in its entirety the amended and restated letter
agreement between you and The Medicines Company (the “Company”), dated [ ].
As an incentive to induce you to [join/maintain your continued employment with]
The Medicines Company, the Company agrees, on the terms and subject to the
conditions set forth in this letter (this “Agreement”), as follows:
1.    As used herein, the following terms shall have the following meanings:
1.1    “Cause” shall mean (i) conviction of (or the entry of a guilty plea or
plea of nolo contendere to) any felony or any crime involving moral turpitude or
dishonesty; (ii) participation in a fraud or act of dishonesty against the
Company or any of its affiliates; (iii) willful and material breach of the
Company’s or any of its affiliates’ policies; (iv) intentional and material
damage to the Company’s or any of its affiliates’ property; (v) materially
unsatisfactory performance of your key duties, responsibilities or objectives,
unless such unsatisfactory performance is cured within ninety (90) days after
written notice; provided, however, that such opportunity to cure shall not be
required where, in the Company’s determination, such unsatisfactory performance
is not capable of cure; or (vi) material breach of your confidentiality
obligations or duties under your non-disclosure, non-competition or other
similar agreement with the Company or any of its affiliates.
1.2    “Change in Control Event” means:
(i)    any sale or transfer of all or substantially all of the assets of the
Company to another corporation or entity, or any merger, consolidation or
reorganization of the Company into or with another corporation or entity, with
the result that, upon conclusion of the transaction, the voting securities of
the Company immediately prior thereto do not represent (either by remaining
outstanding or by being converted into voting securities of the surviving
entity) more than 50% of the combined voting power of the voting securities of
the continuing or surviving entity of such merger, consolidation or
reorganization; or

(ii)     a disclosure that any person (as the term “person” is used in Section
13(d)(3) or Section 14(d)(2) of the Exchange Act), other than (A) any
shareholder who, prior to the Company becoming subject to the reporting
requirements of Section 13 of the Exchange Act, previously held at least 30% of
the combined voting power of outstanding voting securities of the Company, (B)
the Company, or (C) any corporation owned directly or indirectly by the
stockholders of the Company in substantially the same proportion as their
ownership of stock of the Company, has become the beneficial owner (as the term
“beneficial owner” is defined under Rule 13d-3 or any successor rule or
regulation thereto under the Exchange Act) of securities representing 30% or
more of the combined voting power of the then outstanding voting securities of
the Company; or
(iii)    such time as individuals who as of the date hereof constitute the Board
of Directors of the Company, and any new director (other than a director
designated by a person who has entered into an agreement with the Company to
effect any transaction described in clause (i) or (ii) of this section) whose
election by the Board or nomination for election by the Company’s stockholders
was approved by a vote of at least two-thirds of the directors then still in
office who were either directors at the beginning of the period or whose
election or whose nomination for election was previously so approved, cease for
any reason to constitute a majority of the Board of Directors; or
(iv)    the liquidation or dissolution of the Company.
1.3    “Exchange Act” means the Securities Exchange Act of 1934, as amended.

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1.4    “Good Reason” shall mean the Company’s taking any of the following
actions, which actions shall not have been cured within a 30-day period
following written notice by you: (A) the principal place of the performance of
your responsibilities is changed to a location outside of a 30 mile radius from
the Principal Location; (B) there is a material reduction in your
responsibilities without Cause; (C) there is a material reduction in your annual
base salary, unless such reduction is applicable generally to other employees in
your grade level; (D) there is a material reduction in your benefits, bonus
eligibility or equity eligibility, unless such material reduction is also
applicable to other employees in your grade level; or (E) there is a material
breach of the Company’s obligations to you.
1.5    "Payment Date" shall mean the 60th day following the Termination Date,
provided that you have executed the release provided in Section 5 hereof and
have not revoked the release within the applicable revocation period.
1.6    “Principal Location” shall mean the principal place of the performance of
your responsibilities.
1.7    “Termination Date” shall mean the date on which the termination of your
employment shall become effective.
1.8    “Termination Event” shall mean the termination of your employment during
the one-year period following the date of the consummation of a Change in
Control Event (i) by the Company without Cause; or (ii) by you upon written
notice given within thirty (30) days after the Company’s taking any action that
constitutes Good Reason.
2.    If the Company terminates your employment other than for Cause, or if you
terminate your employment for Good Reason, and a Change in Control Event has not
been consummated prior to such termination, subject to Sections 4, 5 and 6
hereof, the Company will pay to you, and you will be entitled to receive:
(i)     on the Payment Date, in a lump sum, an amount equal to two (2) years of
your then current annual base salary; provided that, in the event that the
termination arises as a result of a material reduction in your annual base
salary under item (C) of the definition of Good Reason, then the amount payable
under this Section 2 (i) shall be determined using your annual base salary prior
to such salary reduction, and
(ii)    for a period of twelve (12) months after the Termination Date,
reimbursement of COBRA health care premiums actually paid by you and payment by
the Company for reasonable outplacement assistance of your choosing; provided
that the payments provided in this Section 2 (ii) shall terminate upon your
commencing employment with a new employer and, in any event, all payments must
be made not later than the end of the year following the year in which the
expense was incurred, and
(iii)    accelerated vesting, effective on the Payment Date, of stock options
previously granted to you and outstanding immediately prior to the Termination
Date which would have vested within two (2) years after the Termination Date
(assuming that you had continued to be employed by the Company during such two
(2) year period).
3.    If a Termination Event occurs, subject to Sections 4, 5 and 6 hereof, the
Company will pay to you, and you will be entitled to receive:
(i)     on the Payment Date, in a lump sum, an amount equal to the sum of (A)
two (2) years of your then current annual base salary, plus (B) an amount equal
to two (2) times your then current annual bonus target; provided that, in the
event that the Termination Event arises as a result of a material reduction in
your annual base salary under item (C) of the definition of Good Reason, then
the amount payable under this Section 3 (i) shall be determined using your
annual base salary prior to such salary reduction, and
(ii)    for a period of twenty-four (24) months after the Termination Date,
reimbursement of COBRA health care premiums actually paid by you and payment by
the Company for reasonable outplacement assistance of your choosing; provided
that the payments provided in this Section 3 (ii) shall terminate upon your
commencing employment with a new employer and, in any event, all payments must
be made not later than the end of the year following the year in which the
expense was incurred, and
(iii)    accelerated vesting, effective on the Payment Date, of all stock
options previously granted to you and outstanding immediately prior to the
Termination Date.

4.    (a)    In addition to any other amounts that may be payable to you
hereunder, in the event of the termination of your employment with the Company
for any reason, the Company will pay you (or in the case of death, your spouse
and, in the

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event you have no spouse, your estate), your base salary earned but not yet paid
through the Termination Date, any vacation pay accrued through the Termination
Date payable pursuant to the Company's policies in effect from time to time, any
unreimbursed business expenses incurred through the Termination Date pursuant to
the Company's policies in effect from time to time, and (except if the Company
terminates your employment for Cause), any bonus earned but not yet paid prior
to your Termination Date. The Company will pay the earned but unpaid bonus in
accordance with the terms of the Company’s Annual Incentive Plan.
(b)    The Company may withhold from any and all amounts payable under this
Agreement such federal, state, and local taxes as may be required to be withheld
pursuant to applicable law or regulation. Upon your termination of employment
from the Company, the Company may also offset amounts that you owe to the
Company against any amounts payable to you hereunder as permitted by law.
(c)    If your employment is terminated for any reason, you are not required to
seek other employment or attempt in any way to reduce any amounts payable to you
under this Agreement. The foregoing provision notwithstanding, if you obtain new
employment, the Company does not have any obligation to provide the payment of
COBRA premiums and outplacement services under Sections 2 (ii) and 3 (ii) of
this Agreement.
5.     In order to receive the payments and benefits provided in this Agreement,
you will be required to execute, effective as of the Termination Date, a general
release in favor of the Company, in form and substance reasonably satisfactory
to the Company.
6.     (a)    Any provision in this Agreement (or any agreement or arrangement
referenced herein) that is inconsistent with the requirements of Section 409A of
the Internal Revenue Code of 1986, as amended (the “Code”), and the regulations
issued or to be issued by the Department of the Treasury thereunder (“Section
409A”), including the timing of any payment, shall be promptly amended in a
manner mutually agreed to by the parties hereto in good faith in order to
attempt to avoid triggering adverse tax consequences to you under Section 409A.
(b)    In the event any payment that is either received by you or paid by the
Company on your behalf, or any cash, property or any other benefit provided to
you under this Agreement or under any other plan, arrangement or agreement with
the Company or any other person is treated as contingent on a change of
ownership or control of the Company (or in the ownership of a substantial
portion of the assets of the Company) (collectively, the “Company Payments”),
and is subject to the tax (the “Excise Tax”) imposed by Section 4999 of the Code
(or any successor provision and any similar tax that may hereafter be imposed by
any taxing authority), the amount of the Company Payments shall be automatically
reduced to the maximum amount that can be paid such that no portion of the
Company Payments is subject to the Excise Tax; provided, however, that the
reduction shall occur only if the reduced Company Payments (after taking into
account further reductions for applicable federal, state and local income,
social security and other taxes) would be greater than the unreduced Company
Payments minus (i) the Excise Tax payable with respect to such Company Payments,
and (ii) all applicable federal, state and local income, social security and
other taxes on such Company Payments.
7.    By signing this Agreement, you acknowledge and reaffirm your obligation to
keep confidential all non-public information concerning the Company which you
acquired during the course of your employment with the Company, as stated more
fully in the Invention and Non-Disclosure Agreement, and your obligations not to
compete with the Company or to solicit or hire employees of the Company, as
stated more fully in the Non-Competition and Non-Solicitation Agreement, both of
which agreements you executed at the inception of your employment and which
remain in full force and effect following the termination of your employment.
8.     No supplement, modification, or amendment of this Agreement shall be
binding unless executed in writing by the parties hereto.
9.     This Agreement shall be binding upon and inure to the benefit of the
parties hereto and their respective successors and assigns. This Agreement is
assignable by the Company only to an entity that is owned, directly or
indirectly, in whole or in part by the Company or by any successor to the
Company or an acquirer of all or substantially all of the assets of the Company.
10.    Any provision contained herein to the contrary notwithstanding, if you
are a specified employee (as defined under Treasury Regulation Section
1.409A-1(i)) as of the Termination Date, the Company shall withhold and
accumulate all payments under Sections 2 and 3 to which you would otherwise be
entitled during the first six (6) months after the Termination Date to the
extent required for compliance with Section 409A. In such event, the Company
shall distribute these payments to you (or your beneficiary) in a single lump
sum on the first day of the seventh month after the Termination Date, or within
thirty (30) days after the date of your death after the Termination Date.

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Please indicate your acceptance of and agreement to the foregoing by executing
the enclosed copy of this letter where indicated and returning it to me.

Very truly yours,
THE MEDICINES COMPANY

By:                                         
Name:    
Title:    

ACCEPTED AND AGREED:

                            
NAME            Date