Discovery Partners International, Inc.
Amendment No. 1 to Notice of Grant of Stock Option

This Amendment No. 1 (this “Amendment”) to the Non-Statutory Stock Option Notice
of Grant of Stock Option for 153,616 shares dated as of December 6, 2001 (the
“Agreement”) is made as of January 24, 2003, by and among Craig Kussman
(“Kussman”) and Discovery Partners International, Inc., a Delaware corporation
(“DPI”).

RECITALS

WHEREAS, Executive and DPI are parties to the Agreement; and

WHEREAS, Executive and DPI desire to amend the Agreement as set forth below.

AGREEMENT

NOW, THEREFORE, in consideration of the mutual promises, representations,
warranties, covenants and conditions set forth in this Amendment and the
Agreement, the parties hereby agree as follows:

1. Vesting Schedule Amended. The Vesting Schedule is hereby amended to read in
its entirety as follows:

“The Option Shares shall vest in accordance with the following vesting schedule:

(i)         No Option Shares shall vest unless and until the Optionee has
completed twelve months of Service (as defined in the Plan) measured from the
Vesting Commencement Date.

(ii)        Upon the completion of the twelve (12) month Service period
specified in subparagraph (i) above, 25% of the Option Shares shall become
vested.

(iii)       The Remaining Option Shares shall vest in a series of successive
equal monthly installments over each of the next thirty-six (36) months of
Service completed by the Optionee after the initial twelve (12) month Service
period specified in subparagraph (i) above.

2. Effect of Amendment. Except as expressly modified by this Amendment, the
Agreement shall remain unmodified and in full force and effect.

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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be properly
executed and delivered as of the date first above written.

 

 

 

 

DISCOVERY PARTNERS
INTERNATIONAL, INC.

 

 

By: 

 

 

 

 

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Name: 

 

 

 

 

 

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Title: 

 

 

 

 

 

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CRAIG KUSSMAN