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Exhibit 10.18

OYSTER POINT MARINA PLAZA
Sixth Amendment to Office Lease

THIS Sixth Amendment TO OFFICE LEASE (the "Sixth Amendment") is made and entered
into as of August 1, 2002, by and between KASHIWA FUDOSAN AMERICA, INC., a
California corporation ("Landlord") and TITAN PHARMACEUTICALS, INC., a Delaware
corporation ("Tenant").

Recita1s

A.Landlord and Tenant have heretofore entered into that certain lease dated
February 14, 1996 (the "Lease") for premises originally described as Suite 505
(the "Premises"), initially containing approximately 3,866 rentable square feet
of space in the building located at 400 Oyster Point Boulevard, South San
Francisco, California (the "Building"), which forms part of the office building
complex commonly known as Oyster Point Marina Plaza (the "Complex").

B.The Lease has heretofore been amended by the following instruments
(collectively the "Addenda"):

 
 
(i).
 
First Amendment to Lease dated as of March 25, 1997;
 
 
(ii).
 
Second Amendment to Lease dated as of May 22, 1998;
 
 
(iii).
 
Third Amendment to Lease dated as of November 11, 2000;
 
 
(iv).
 
Fourth Amendment to Lease dated as of April 9, 2001; and
 
 
(v).
 
Fifth Amendment to Lease dated as of December 5, 2001.
    
 
 
 
 

C.The parties mutually desire to amend the terms of the Lease to extend its
Term, expand the Premises, and in certain other respects, all on and subject to
the terms and conditions hereof.

Agreement

Now, therefore, in consideration of the mutual terms and conditions herein
contained and of other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties agree as follows:

1 EFFECT OF AMENDMENT. Landlord and Tenant agree that, notwithstanding anything
contained in the Lease to the contrary, the provisions set forth below will be
deemed to be part of the Lease and shall supersede, to the extent they differ,
any contrary provisions in the Lease. Terms defined in the Lease shall have the
same meanings in this Sixth Amendment, unless a different definition is set
forth in this Sixth Amendment. The term Lease as used herein shall be deemed to
include the Addenda, each of which may also be referred to separately herein.

2 EFFECTIVE DATE. The amendments and changes specified in this Sixth Amendment
shall become effective on October 1, 2002 (the "Effective Date").
Notwithstanding the foregoing, this Sixth Amendment shall constitute the
fully-binding agreement and contract of the parties from and after the date of
the parties execution and delivery of this Sixth Amendment to each other.

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3 SUMMARY TABLE. The Table set forth in ¶ 4 of Fifth Amendment is hereby
superseded and replaced in its entirety by the following table, which shall
constitute the Table under § 1.2 of the Lease for all purposes from and after
the Effective Date of this Sixth Amendment:

PERIODS

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SUITE
NO.

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RSF

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USF

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MONTHLY
BASE
RENT

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TENANT'S
SHARE
BLDG

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TENANT'S
SHARE
COMPLEX

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BASE
YEAR

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October 1, 2002 through June 30, 2003
 
505
504
 
18,774
3,821
 
16,325
3,323
 
$
$
51,628.50
3,821.00
 
8.100%
1.649%
 
4.042%
0.823%
 
2000
July 1, 2003 through June 30, 2004
 
505
504
 
18,774
3,821
 
16,325
3,323
 
$
$
56,322.00
4,012.05
 
8.100%
1.649%
 
4.042%
0.823%
 
2000
July 1, 2004 through June 30, 2005
 
505
504
 
18,774
3,821
 
16,325
3,323
 
$
$
61,015.50
4,203.10
 
8.100%
1.649%
 
4.042%
0.823%
 
2000
July 1, 2005 through June 30, 2006
 
505
504
 
18,774
3,821
 
16,325
3,323
 
$
$
64,770.30
4,394.15
 
8.100%
1.649%
 
4.042%
0.823%
 
2000
July 1, 2006 through June 30, 2007
 
505
504
 
18,774
3,821
 
16,325
3,323
 
$
$
46,935.00
9,552.50
 
8.100%
1.649%
 
4.042%
0.823%
 
2000

In the event of any conflict between the terms contained in the Table and the
terms contained in subsequent paragraphs of this Sixth Amendment, the terms of
the Table shall control, except as may be expressly varied in any subsequent
paragraph of this Sixth Amendment.

4 EXPANSION OF PREMISES. Upon Substantial Completion of the Work specified in
the Work Letter Agreement, as described in ~8 below, the Premises shall be
expanded to include approximately 3,821 rentable square feet of space known as
Suite 504 in the Building ("Suite 504") for all purposes under the Lease. The
parties anticipate that Substantial Completion of Landlord's Work in Suite 504
will occur on or before October 1, 2002 (the "Target Date"). From and after the
later to occur of the Target Date or Substantial Completion of Landlord's Work
under the Work Letter Agreement specified in ¶ 8 below, Suite 504 shall become
part of the Premises pursuant to the basic terms specified in the Table above
regarding term, Base Rent, Tenant's Share of increases in Operating Expenses and
Taxes, and the Base Year for the purposes of calculating Additional Rentable
payable with respect to Suite 504.

5 EXTENSION OF LEASE TERM. The Term of the Lease specified in § 1.4 of the
Lease, as heretofore modified in the Addenda, is hereby extended for an
additional period of one (1) year commencing on July 1, 2006, and the Expiration
Date of the Lease is hereby amended accordingly to June 30, 2007, for the entire
Premises (including Suite 504).

6 EXTENSION TERM BASE RENT. The Base Rent for the Premises specified in § 1.5 of
the Lease, as heretofore modified in the Addenda, shall be the amounts specified
as Monthly Base Rent in the Table above for the various periods and spaces set
forth in the Table from and after the Effective Date.

7 BASE YEAR. As specified in the Table above, the Base Year for the purposes
calculating Tenant's Share of Increased Operating Expenses and Increased Taxes
under Article 4 of the Lease shall be calendar year 2000Jrom and after the
Effective Date.

8 CONDITION OF PREMISES. Except as otherwise expressly provided in the "Work
Letter Agreement" which shall be executed by Landlord and Tenant concurrently
with their execution of this Sixth Amendment substantially in the form attached
hereto as Exhibit A with respect to Landlord's preparation of Suite 504 for
Tenant's occupancy, Tenant shall accept the Premises, any existing Improvements
in the Premises, and the Systems and Equipment serving the same in an "as is"

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condition on the Extension Term Commencement Date, and Landlord shall have no
obligation to improve, alter, remodel, or otherwise modify the Premises in
connection with Tenant's continued occupancy of the Premises from and after the
Effective Date.

8.1Landlord's Preparation. Landlord shall use reasonable diligence in completing
and preparing the Premises for Tenant's occupancy in the manner and subject to
the terms, conditions, and covenants set forth in the Work Letter Agreement. The
facilities, materials, and work to be furnished, installed, and performed in the
Premises by Landlord pursuant to the Work Letter Agreement are referred to as
the "Work." Such other installations, materials, and work which may be
undertaken by or for the account of Tenant to prepare, equip, decorate, and
furnish the Premises for Tenant's occupancy are referred to as the "Tenant's
Work."

8.1.1Readiness for Occupancy. The Premises shall be deemed ready for occupancy
on the earliest date on which all of the following conditions (the "Occupancy
Conditions") have first been met:

(a)Substantial Completion of Work. The Work has been substantially completed;
and it shall be so deemed notwithstanding the fact that minor or insubstantial
details of construction, mechanical adjustment, or decoration remain to be
performed, the noncompletion of which does not materially interfere with
Tenant's beneficial use of the Premises for their intended purposes;

(b)Access and Services. Reasonable means of access and facilities necessary to
Tenant's use and occupancy of the Premises, including corridors, elevators,
stairways, heating, ventilating, air-conditioning, sanitary, water, and
electrical facilities (but exclusive of parking facilities) have been installed
and are in reasonably good operating order and available to Tenant; and

(c)Certificate of Occupancy or Completion. A certificate of occupancy,
certificate of completion, final inspection card, or similar required
governmental approval (temporary or final) has been issued by the City of South
San Francisco permitting use of the Premises for office purposes.

8.2Notice of Defects. It shall be conclusively presumed upon Tenant's taking
actual possession of the Premises that the same were in satisfactory condition
(except for latent defects) as of the date of such taking of possession, unless
within thirty (30) days after the Commencement Date Tenant shall give Landlord
notice in writing specifying the respects in which the Premises were not in
satisfactory condition.

9 SECURITY DEPOSIT. Tenant shall increase the Security Deposit specified in §
5.1 of the Lease from Six Thousand Two Hundred Dollars ($6,200.00) to a total of
Forty-Eight Thousand Dollars ($48,000.00) in four installments of $10,450.00,
each, to be paid to Landlord on the following dates; September 1, 2002;
December 1, 2002; March 1, 2003 and June 1, 2003.

10 PARKING. The number of parking spaces specified in § 28.1 of the Lease as
available for Tenant's use is hereby amended to Sixty-Six (66).

11 OPTION TO RENEW. Tenant's Extension Option specified in § 1.7 of the Lease
shall apply to the period following the Expiration Date of the Lease as amended
in ¶ 5 above.

12 RIGHT OF FIRST OFFER. From the Commencement Date through June 30, 2005;
Tenant shall have the first right of offer on adjacent space on either side of
the Premises (Suite 504-505), subject to the existing tenants, Greenspan and any
third party occupying the suite adjacent to Suite 504, vacating the space and
delivering it vacant and unencumbered to Landlord. The rent for the first right
of offer shall be 95% of the Fair Market Value or Titan's rent schedule,
whichever is greater. The term for the adjacent space shall be co-terminus with
the term under the Lease. Tenant acknowledges that it has

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receive the first right of offer upon the expiration and vacation of Suite 504
by the U.S. Postal Service as specified in Amendment Four of the Lease.

13 NO DISCLOSURE. Tenant agrees that it shall not disclose any of the matters
set forth in this Sixth Amendment or disseminate or distribute any information
concerning the terms, details, or conditions hereof to any person, firm, or
entity without obtaining the express written approval of Landlord.

14 NO OFFER. Submission of this Sixth Amendment is not an offer to enter into
the same but a solicitation for such an offer by Tenant. Tenant agrees that its
execution of this Sixth Amendment constitutes a firm offer to enter the same
which may not be withdrawn for a period of thirty (30) working days after
delivery to Landlord. Landlord shall not be bound by this Sixth Amendment until
Landlord has executed and delivered the same to Tenant. This Sixth Amendment
shall not be relied upon by any other party, individual, corporation,
partnership, or other entity as a basis for terminating its lease with Landlord.

15 DEFINED TERMS. Terms used herein that are defined in the Lease shall have the
meanings therein defined, unless a different definition is set forth in this
Sixth Amendment. In the event of any conflict between the provisions of the
Lease, and this Sixth Amendment, the terms of this Sixth Amendment shall
prevail.

16 SURVIVAL. Warranties, representations, agreements, and obligations contained
in this Sixth Amendment shall survive the execution and delivery of this Sixth
Amendment and shall survive any and all performances in accordance with this
Sixth Amendment.

17 COUNTERPARTS. This Sixth Amendment may be executed in any number of
counterparts, which each severally and all together shall constitute one and the
same Sixth Amendment.

18 ATTORNEYS' FEES. If any party obtains a judgement against any other party or
parties by reason of breach of this Sixth Amendment, reasonable attorneys' fees
and costs as fixed by the court shall be included in such judgement against the
losing party or parties.

19 SUCCESSORS. This Sixth Amendment and the terms and provisions hereof shall
inure to the benefit of and be binding upon the heirs, successors, and assigns
of the parties.

20 AUTHORITY. Each of the individuals executing this Sixth Amendment represents
and warrants that he or she is authorized to execute this Sixth Amendment on
behalf of the party for whom he or she is executing this Sixth Amendment and
that by his or her signature such party is legally bound by the terms,
covenants, and conditions of this Sixth Amendment.

21 GOVERNING LAW. This Sixth Amendment shall be construed and enforced in
accordance with the laws of the State of California.

22 CONTINUING VALIDITY OF LEASE. Except as expressly modified herein, the Lease
remains in full force and effect.

23 CONFLICTS. In the event of any conflict between the provisions of this Sixth
Amendment and those of the Lease or of the Addenda, the terms and conditions of
this Sixth Amendment shall control.

24 WHOLE AGREEMENT. The mutual obligations of the parties as provided herein are
the sole consideration for this Sixth Amendment, and no representations,
promises, or inducements have been made by the parties other than as appear in
this Sixth Amendment, which supersedes any previous negotiations. There have
been no representations made by the Landlord or understandings made between the
parties other than those set forth in this Sixth Amendment. This Sixth Amendment
may not be amended except in writing signed by all the parties.

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IN WITNESS WHEREOF, the parties have executed this Sixth Amendment as of the
date first above written.

Landlord:   KASHIWA FUDOSAN AMERICA, INC., a California corporation
 
 
By:
/s/ Haru Takehana

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Haru Takehana, Vice President
Tenant:
 
TITAN PHARMACEUTICALS, INC., a Delaware corporation
 
 
By:
/s/ Louis R. Bucalo

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Louis R. Bucalo, M.D.     Its: Chairman, CEO and President

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Exhibit 10.18

Agreement