CONFIDENTIAL TREATMENT REQUESTED. CERTAIN PORTIONS OF THIS DOCUMENT HAVE BEEN
OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT AND, WHERE APPLICABLE,
HAVE BEEN MARKED WITH AN ASTERISK TO DENOTE WHERE OMISSIONS HAVE BEEN MADE. THE
CONFIDENTIAL MATERIAL HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION.

PILOT PLANT SERVICES AGREEMENT
THIS PILOT PLANT SERVICES AGREEMENT (“Agreement”) is made and entered into as of
April 4, 2014 (the “Effective Date”) by and between Amyris, Inc., having its
principal place of business located at 5885 Hollis St, Suite 100, Emeryville, CA
94608 (“Amyris”), and TOTAL New Energies USA, Inc., a corporation incorporated
under the laws of the state of Delaware, having its principal place of business
located at 5858 Horton Street, Emeryville, CA 94608 (“TOTAL”). Amyris and TOTAL
may each be referred to herein individually as a “Party” and collectively as the
“Parties.”
WHEREAS, TOTAL desires to receive pilot plant scale fermentation process
development services, fermentation and downstream separations scale-up services,
and training for certain of its employees on the aforementioned technologies in
order to support its projects in the field of industrial biotechnology.
WHEREAS, Amyris has a fermentation pilot plant facility (the “Pilot Plant”) and
personnel with fermentation and downstream separations scale-up expertise and
agrees to provide certain fermentation and downstream separations scale-up
services and training to TOTAL as outlined below; and
WHEREAS, Amyris has agreed to allow TOTAL to occupy certain portions of the
Pilot Plant pursuant to that certain Sublease, entered into as of even date
herewith, between Amyris and TOTAL (the “Sublease”);
NOW, THEREFORE, in consideration of the foregoing promises and the mutual
covenants contained herein, the Parties agree as follows:
1. Services and Joint Oversight Team.
(a)    Amyris agrees to perform the fermentation and downstream separations
scale-up activities and training at the Pilot Plant for TOTAL as set forth on
Exhibit A hereto (the “Services”), which exhibit is incorporated herein by
reference. The Services and other terms and conditions set forth in Exhibit A
may be supplemented and/or amended from time to time upon the execution of a
revised Exhibit, signed by both Parties. Such revised Exhibit shall be subject
to all the terms and conditions of this Agreement.
(b)    At all times during the Term, TOTAL and Amyris shall each designate and
maintain two (2) individuals to constitute a “Joint Oversight Team” for all
Services to be performed under this Agreement. The Joint Oversight Team shall
review from time to time the overall progress of the Services and shall, upon
request by either Party, review and attempt to informally resolve, as provided
in Section 7(a) of the Agreement, any problems or disputes that may arise
pertaining to such Services. At the Effective Date, TOTAL’s representatives
shall be its Head of Biotech, R&D and its Head of the Biotechnology Department,
Technology, Operations & Projects Division, and Amyris’s representatives shall
be its President of Research and Development and its Director of Fermentation.
TOTAL and Amyris may each change the persons it designates to serve as its
representative

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on the Joint Oversight Team at any time and from time-to-time during the Term at
its discretion.
2.    Service Fees and Expenses; Recordkeeping and Inspection.
(a)    Payment for Services. The annual fee payable by TOTAL to Amyris for all
Services within a calendar year is $ 895,327 (each year’s fee being the
applicable “Annual Fee” for such year). This Annual Fee will include the total
cost of the Services, including, without limitation, all costs associated with
staff, lab equipment, leasehold improvements, nutrients, sugar, materials,
chemicals, consumables and other items required to perform the Services.
(b)    No Adjustments. The Annual Fee is fixed as provided above and is not
subject to adjustment.
(c)    Payment Terms. The Annual Fee is due in three (3) equal installments
payable on March 1, July 1 and November 1 of each year during the Term. The
Parties agree that first Annual Fee payment for 2014 will be due and payable
within fifteen (15) days after the Effective Date, rather than on March 1, 2014
(and Amyris shall generate and submit to TOTAL an electronic invoice on the
Effective Date for such amount). After the first Annual Fee payment, and for all
subsequent payment, Amyris shall generate an electronic invoice to be submitted
to TOTAL thirty (30) days prior to the each installment due date. Each
installment will be paid in U.S. Dollars by wire transfer in immediately
available funds to an account designated in writing in advance by Amyris.
(d)    Reports. Amyris shall create and maintain complete and accurate records,
and raw data files in accordance with Amyris’s standard record keeping policies,
which fully and properly reflect all Services performed by it and the results
thereof, including, but not limited to, the time and date equipment in the OCT
Facilities is utilized to conduct each Campaign, the amount of time expended by
each OCT Personnel to perform each of the Services (including, without
limitation, the time expended on each step of each Campaign) (the “Records”).
The Records shall include, without limitation, appropriate detail for
intellectual property and regulatory purposes and such information, data and
materials as are required to be maintained pursuant to any applicable law,
ordinance, rule, regulation or guideline and Exhibit A.
(e)    Recordkeeping. All Records shall be kept separately from documentation,
records, and materials associated with other Amyris activities. Amyris shall
maintain the Records for one (1) year after expiration or earlier termination of
the Agreement or such other longer amount of time as is required by any law,
ordinance, rule, regulation or guideline applicable with respect to the
Services. Prior to destroying any Records, Amyris shall give TOTAL at least
sixty (60) days’ prior written notice of Amyris’s intention to destroy such
Records and include with such notice a summary of such Records proposed to be
destroyed containing sufficient detail for TOTAL to determine the content of
such Records. Upon TOTAL’s written request, and at TOTAL’s expense, Amyris shall
deliver to

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TOTAL all original Records, or if requested by TOTAL, certified or authenticated
complete legible copies of such Records.
(f)    Records Access. Access to all Records, for inspection and copying, shall
be made available by Amyris to TOTAL and/or TOTAL’s designees at any time during
normal business hours at Amyris’s Emeryville offices upon five (5) business
days’ prior notice.
(g)    To the extent that an item in the Records relates exclusively to a
Service, such item shall not be used by Amyris for any purpose other than
performing the Services or as otherwise expressly required by this Agreement,
and shall be deemed TOTAL Confidential Information (as defined below).
3.    Confidentiality.
(a)    Definition. “Confidential Information” means the information and material
that either Amyris or TOTAL or their respective Affiliates (in such disclosing
capacity, the “Disclosing Party”) has disclosed or may disclose per this
Agreement to the other Party or its Affiliates (the “Receiving Party”) relating
to the Disclosing Party’s business, including without limitation trade secrets,
processes, formulae, data and know-how, improvements, inventions, chemical or
biological materials, techniques, standard operating procedures (“SOP”), methods
for making compounds, target compounds, product development plans, marketing
plans, strategies, customer lists, or other information that has been created,
discovered, or developed by the Disclosing Party, or has otherwise become known
or provided to the Disclosing Party, or which proper rights have been assigned
to the Disclosing Party, as well as any other information and materials that are
deemed confidential or proprietary to or by the Disclosing Party (which may
include, without limitation, information and materials of the Disclosing Party’s
customers and consultants and other third parties). For clarity, all information
disclosed, whether in oral, written, graphic or electronic form, pursuant to an
SOW (as defined in Exhibit A) shall be considered Confidential Information of
TOTAL and all other information will be considered Confidential Information of
the Disclosing Party if the Disclosing Party has provided a non-confidential
summary (which may be written or oral) of the items proposed to be disclosed
between the Disclosing Party and the Receiving Party and the Receiving Party has
agreed to accept such information and such acceptance is reflected by the
parties in writing. However, SOPs pertaining to the operation of equipment in
the OCT Facilities (as defined in the Sublease) shall not be deemed as
Confidential Information of either Party. For purposes of this Agreement, an
“Affiliate” of a Party means an entity directly or indirectly controlling,
controlled by or under common control with that Party where controlling,
controlled or control means the ownership or control, directly or indirectly, of
at least fifty percent (50%) (or the maximum ownership or control permitted
under applicable law, if lower) of all of the voting power of the shares (or
other securities or rights) entitled to vote for the election of directors or
other governing authority, as of the date of this Agreement or hereafter during
the Term; provided that such entity shall be considered an Affiliate only for
the time during which such control exists.
(b)    Use. Except with the prior written consent of the Disclosing Party or as

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contemplated by this Agreement, each Receiving Party agrees to:
(i)    protect, maintain in confidence any and all Confidential Information of
the Disclosing Party, including any information derived therefrom;
(ii)    not to disassemble, reverse engineer, decompile, reproduced or
distributed in whole or in part any Confidential Information of the Disclosing
Party;
(iii)    only disclose the Confidential Information of the Disclosing Party to
each Affiliate, employee, officer, director, consultant or agent of the
Receiving Party who has a legitimate “need to know” and who is bound by written
agreements with the Receiving Party to restrictions substantially similar to the
restrictions herein. For the avoidance of doubt, Amyris shall not disclose any
TOTAL Confidential Information to anyone except (1) OCT Personnel, (2) Amyris’
members of the Joint Oversight Team and/or officers as needed to resolve
disputes pursuant to Section 7(a) below, (3) members of Amyris’ legal department
or outside counsel, or (4) as required by applicable law or regulation, without
the express prior written consent of TOTAL;
(iv)    take all reasonable precautions to prevent disclosure to, and use by,
any person or entity of any Confidential Information of the Disclosing Party;
(v)    not to make use of the Confidential Information of the Disclosing Party
except in performance of its obligations or executing its rights hereunder;
(vi)    notify the Disclosing Party, promptly and in writing, of any actual or
suspected misappropriation or unauthorized use or disclosure of the Confidential
Information that may come to the Receiving Party’s attention; and
(vii)    notify the Disclosing Party in the event that the Pilot Plant Manager
or TOTAL BPP Coordinator, as the case may be, has authorized disclosure of the
Disclosing Party’s Confidential Information as set forth in Schedules 1 or 1A,
as applicable.
(c)    Exceptions. The Disclosing Party agrees that the restrictions set forth
in this Section 3 above shall not apply with respect to any information that the
Receiving Party can document (i) is or (through no improper action or inaction
by the Receiving Party or any Affiliate, agent, consultant or employee) becomes
generally available or known to the public, (ii) was rightfully in its
possession or known by it prior to receipt from the Disclosing Party, (iii) was
rightfully disclosed to it by a third party having no obligation of
confidentiality, or (iv) was independently developed without use of any
Confidential Information of the Disclosing Party. The Receiving Party may make
disclosures of Confidential Information that are required by court order or
applicable law provided the Receiving Party promptly notifies the Disclosing
Party of any such request, demand, or requirement for disclosure and uses
diligent efforts to limit disclosure and to obtain, if applicable, confidential
treatment or a protective order and has allowed the Disclosing Party to
participate in the proceeding. Notwithstanding the foregoing, all Confidential
Information designated as owned by or assigned to TOTAL in connection with this

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Agreement shall be deemed Confidential Information of TOTAL disclosed by TOTAL
to Amyris and exceptions (ii) and (iv) above will not be applicable thereto.
(d)    Return of Materials. Except as otherwise provided herein, immediately
upon a written request by the Disclosing Party at any time, the Receiving Party
will turn over to the Disclosing Party all Confidential Information of the
Disclosing Party and all documents or media containing any such Confidential
Information and any and all copies or extracts thereof. Notwithstanding this
Section 3(d), nothing herein shall prevent either Party from retaining copies of
Confidential Information of the Disclosing Party as necessary to comply with
applicable law and regulation, provided that such copies shall only be accessed
by members of the Receiving Party’s legal counsel and internal finance group,
and for no other use.
(e)    Remedies. The Parties acknowledge that their obligations under this
Section 3 are necessary and reasonable to protect the Confidential Information
and expressly agree that monetary damages would be inadequate to compensate the
Disclosing Party for the breach of any of the terms and conditions of this
Section 3. In addition to any other remedies that may be available, in law, in
equity, or otherwise, the Disclosing Party is entitled to seek appropriate
equitable relief as set forth in Section 7 below.
4.    Intellectual Property.
(a)    Existing Intellectual Property. Each Party will retain all of its right,
title and interest in and to its own intellectual property in existence prior to
the Effective Date.
(b)    Inventions. “Inventions” shall mean any and all inventions, discoveries,
data and information, whether or not copyrightable or patentable, conceived,
reduced to practice, made, observed or developed by a Party or its Affiliates,
together with all intellectual property, industrial or other proprietary rights
related thereto.
(c)    Ownership of Work Product Inventions. All Inventions arising or developed
pursuant to the performance of Services under an SOW that comprise improvements
or modifications to either equipment or operating procedures for such equipment
or sample preparations for farnesene that are owned, controlled or licensed by
Amyris and used by Amyris in the performance of the Services under an SOW shall
be exclusively owned by Amyris (“Amyris Inventions”); provided, that Amyris
hereby grants TOTAL a nonexclusive, irrevocable, perpetual, non-transferable,
royalty-free license to exploit and exercise all such Amyris Inventions in
support of TOTAL’s exercise or exploitation of the TOTAL Inventions (including
any modifications, improvements and derivatives of any of them). If Amyris
rejects this Agreement under the Bankruptcy Code and TOTAL elects to retain its
rights, (x) the waivers under Bankruptcy Code Section 365(n)(2)(C) shall apply
only to rights of setoff and administrative claims arising solely out of this
Section 4(c), and not to any other rights under this Agreement, or any other
agreements or instruments; and (z) Amyris shall, without need for notice or
hearing, provide to TOTAL a copy of any intellectual property (including any
embodiments) held by Amyris or its Affiliates comprising the Amyris Inventions
to enable Total to exercise its non-exclusive license in and to the Amyris

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Inventions, and shall not interfere with the rights of TOTAL to such
intellectual property (including any embodiments) including any right to obtain
such intellectual property (and embodiments) from any Affiliate. Except as
provided in Section 4(d) below, all other Inventions arising or developed
pursuant to the performance of Services under an SOW shall be exclusively owned
by TOTAL (“TOTAL Inventions”). Amyris shall (and shall cause each of its
Affiliates and each of their respective representatives, employees or agents) to
assign, and hereby does assign to TOTAL (or an entity designated by TOTAL in
writing), all rights, title and interest in and to such TOTAL Inventions.
(d)     Ownership under the Biofene Program. Notwithstanding Section 4(c), all
Inventions arising or developed pursuant to the performance of Services under a
SOW for Campaigns to be operated pursuant to the Technology License,
Development, Research and Collaboration Agreement, dated June 21, 2010 as
amended by that a certain first Amendment dated as of November 23, 2011 and by a
certain second amendment to the Technology, License, Development, Research and
Collaboration dated as of July 30, 2012 the Second Amendment, by and between
Amyris and TOTAL Energies Nouvelles Activités USA, SAS (the “Collaboration
Agreement”) shall be governed by the terms of the Collaboration Agreement.
(e)    No Rights Granted. Neither Party, pursuant to this Agreement, either
expressly or by implication, grants to the other Party any type of rights or
licenses to use any of its intellectual property (including its Confidential
Information and Inventions) other than as set forth in this Agreement.
5.    Indemnification and Insurance.
(a)    TOTAL agrees to indemnify and hold harmless Amyris from any and all
liability, loss (including attorneys’ fees), or damage they may suffer as the
result of claims, demands, costs, or judgments against them (collectively,
“Damages”) to the extent arising out of (i) any actions or omissions of TOTAL or
its subcontractors with respect to the performance of the Services, (ii) gross
negligence or willful misconduct on the part of TOTAL or its subcontractors with
respect to the performance of the Services, (iii) actual or alleged infringement
or misappropriation of a third party’s intellectual property through use of
material (including cells and strains) provided by or on behalf of TOTAL or its
Affiliates to Amyris for use in the Services, or (iv) a breach of any applicable
federal, state or local law by TOTAL or its subcontractors.
(b)     Amyris agrees to indemnify and hold harmless TOTAL from any and all
Damages to the extent arising out of any (i) actions or omissions of Amyris or
its subcontractors with respect to the performance of the Services, (ii) gross
negligence or willful misconduct on the part of Amyris or its subcontractors
with respect to the performance of the Services or (iii) a breach of any
applicable federal, state or local law by Amyris or its subcontractors.
(c)    For the avoidance of doubt, this Section does not cover or address any
liability that could be an indemnifiable claim under the Sublease.

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(d)    Each Party’s agreement to indemnify and hold the other harmless is
conditioned on the indemnified Party (i) providing written notice to the
indemnifying Party of any claim, demand or action (“Claim”) arising out of the
indemnified activities within thirty (30) days after the indemnified Party has
knowledge of such Claim; (ii) permitting the indemnifying Party to assume full
responsibility to investigate, prepare for and defend against any such Claim;
(iii) assisting the indemnifying Party, at the indemnifying Party’s reasonable
expense, in the investigation of, preparation for and defense of any such Claim;
and (iv) not compromising or settling such Claim without the indemnifying
Party’s written consent. The indemnifying Party shall not settle a Claim in any
manner that admits fault on behalf of the indemnified Party or imposes
injunctive relief on the indemnified Party without such Party’s prior written
consent.
(e)    Each of TOTAL and Amyris shall maintain the following insurance coverage
provided by an admitted insurer with an AM Best rating of A and a financial size
rating of VII or greater:
(i)    Workers’ Compensation insurance including Occupational Disease coverage
in accordance with the laws of the federal, state and local governments having
jurisdiction(s) over Emeryville, CA and Employers’ Liability Insurance
(including Borrowed Servant and Voluntary Compensation) with a limit of not less
than $1,000,000 for each accident;
(ii)    Commercial General Liability Insurance with a combined single limit of
$1,000,000 per occurrence and shall include, but not be limited to, coverage for
death, bodily injury and property damage, and products-completed operations
coverage applicable to bodily injury, sickness or death and for loss of or
damage to property;
(iii)    Automobile Liability Coverage for owned, non-owned, hired and all other
vehicles used by Company, its employees and agents with a combined single limit
of $1,000,000 applicable to bodily injury, sickness or death of any person, or
loss of or damage to property for any one occurrence;
(iv)    Umbrella liability insurance with a limit of $5,000,000 per occurrence
providing liability insurance excess of the coverages listed above; and
(v)    All policies shall provide a waiver of subrogation in favor of the other
Party. The Commercial General Liability policy shall name the other Party as
additional insured solely for the liabilities assumed in this agreement. Each
Party shall be notified of material change or cancellation of insurance
according to the policy provisions. Upon request, the Parties shall provide
certificates of insurance evidencing compliance with this agreement.
6.    Term and Termination.
(a)    This Agreement will commence on the Effective Date and will continue for
a five (5) year period or the earlier date of termination as provided below (the
“Term”).

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(b)    TOTAL may terminate this Agreement for convenience at any time upon
ninety (90) days’ prior written notice, provided that TOTAL will, as Amyris’s
sole and exclusive remedy, the effective date upon of such termination, pay
Amyris (i) any fee(s) due under Exhibit A for the Services provided up to and
including the effective date of notification of such termination, and (ii) an
additional payment equal to the amount due for the Annual Fee for the next year
of Services.
(c)    In addition to any other rights or remedies it may have, TOTAL may
terminate this Agreement upon sixty (60) days’ written notice (i) if Amyris
materially breaches any of the terms or conditions of this Agreement, and such
breach is not cured within such sixty (60) day period, or (ii) upon the
occurrence of any event that is a “Default” under Sections 15.1.1, 15.1.2,
15.1.3 (but only if a default under that subsection results in a termination of
the Sublease), 15.1.4, 15.1.5, and 15.1.7 of the Sublease.
(d)    Amyris may terminate this Agreement (i) upon forty five (45) days’
written notice if TOTAL fails to pay any undisputed invoice when due, and such
invoice is not paid within such forty five (45) day period, or (ii) upon sixty
(60) days’ written notice if TOTAL materially breaches Section 3 or 5(a) of this
Agreement, and such breach is not cured within such sixty (60) day period.
(e)    Sections 3, 4, 5, 7, 6(e), 8 and 9 shall survive any termination or
expiration of this Agreement in accordance with their respective terms.
7.    Dispute Resolution.
(a)    If there is a dispute between the Parties arising out of or in connection
with this Agreement, including, but not limited to, any actual or alleged breach
of the Agreement the OCT Manager and the TOTAL BPP Coordinator will negotiate in
good faith to resolve it amicably within five (5) business days. If no solution
is found by such date, either Party may give written notice of such dispute to
the Joint Oversight Team, and the Joint Oversight Team shall then negotiate in
good faith to resolve the dispute. If the Joint Oversight Team does not resolve
such dispute to the satisfaction of both Parties within five (5) business days
from the date of the initial notice of a dispute to the Joint Oversight Team,
the Parties shall each escalate such dispute to their respective officers, who
shall meet by phone or in person within ten (10) business days from the date of
the initial notice to the Joint Oversight Team and endeavor to resolve such
dispute. If (and only if) the respective officers are unable to resolve such
dispute, and such dispute is not related to an actual or alleged breach by
TOTAL, TOTAL shall be entitled to suspend payment of any amounts that may become
due hereunder until such dispute is resolved to the mutual satisfaction of the
Parties
(b)    In the event that any such dispute between the Parties about a breach or
alleged breach of this Agreement cannot be resolved pursuant to the process
described in Section 7(a) within a period of sixty (60) days after the initial
notice to the Joint Oversight Team (the last day of such sixty (60) day period
being herein referred to as the “Arbitration Date”), such dispute shall be
referred to and be finally settled in accordance with the Rules

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and Procedures of JAMS then in effect (the “Rules”), without recourse to the
ordinary courts of law, by three arbitrators with substantial experience in
resolving complex commercial contract disputes. Each of the Parties shall
nominate an arbitrator, and the two so nominated shall, once their appointment
is confirmed by JAMS, nominate the third arbitrator, who shall act as
Chairperson of the arbitral tribunal. If, however, the two arbitrators nominated
by TOTAL and Amyris cannot agree upon a third arbitrator within thirty (30) days
of their confirmation, the third arbitrator shall be chosen by JAMS in
accordance with the Rules. The seat or legal place of arbitration shall be New
York City (United States). The language shall to be used in the arbitral
proceedings shall be English. For clarity, disputes arising pursuant to the
Services shall initially be addressed by the dispute resolution section in
Exhibit A. In the event a dispute regarding the Services cannot be resolved by
mutual agreement of the Parties under the Joint Oversight Team section in
Exhibit A, then this provision will govern. Notwithstanding anything to the
contrary, either Party may seek injunctive or other forms of equitable relief
without the necessity of proving actual damages at any time from any court of
competent jurisdiction.
(c)    The Parties intend that these provisions will be valid, binding,
enforceable, and irrevocable and will survive any termination of this Agreement
and shall be the sole and exclusive set of procedures for the resolution of any
dispute between the Parties arising out of or in connection with this Agreement.
8.    Representations, Warranties and Covenants.
(a)    Amyris represents, warrants and covenants that:
(i)    the Services will be performed in a professional and workmanlike manner
and in full compliance with all applicable laws and regulations, Exhibit A and
the applicable SOW;
(ii) none of the Services or any part of this Agreement is or will be
inconsistent with any obligation Amyris may have to others; all work under this
Agreement shall be performed by OCT Personnel, and to the best of Amyris’s
knowledge, such work will not infringe or misappropriate any intellectual
property rights of Amyris, any of its Affiliates nor any third party; Amyris has
the full right to provide TOTAL with the assignments and rights provided for
herein; and
(i)    in performing the Services, Amyris will not, without TOTAL’s prior
written consent, disclose to TOTAL or use for its benefit any trade secret or
proprietary or confidential information of any third party.
(b)    Each Party represents and warrants to the other that: (i) it is duly
organized, validly existing and in good standing under the laws of its
jurisdiction of incorporation or formation, and has all requisite corporate
power and authority to enter into this Agreement and to carry out the provisions
hereof; (ii) it is duly authorized to execute and deliver this Agreement and to
perform its obligations hereunder, and the person or persons executing this
Agreement on its behalf has been duly authorized to do so by all requisite
corporate or partnership action; (iii) this Agreement is legally binding upon
it, enforceable against it in

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accordance with its terms, except as enforcement may be limited or affected by
applicable bankruptcy, insolvency, moratorium, reorganization or other laws of
general application relating to or affecting creditors' rights generally in
accordance with its terms; and (iv) execution of this Agreement does not
conflict with any agreement, instrument or understanding, oral or written, to
which it is a Party or by which it may be bound, nor violate any material law or
regulation of any court, governmental body or administrative or other agency
having jurisdiction over it.
(c)    Each Party understands and agrees that except as expressly provided
herein, the Services, training and any materials provided hereunder are provided
AS IS WITHOUT REPRESENTATION OR WARRANTY, INCLUDING WARRANTY OF MERCHANTABILITY
OR FITNESS FOR A PARTICULAR PURPOSE OR ANY OTHER WARRANTY, EXPRESS OR IMPLIED.
(d)    EXCEPT FOR VIOLATIONS OF SECTION 3, IN NO EVENT WILL EITHER PARTY BE
LIABLE UNDER ANY LEGAL OR EQUITABLE THEORY OF LIABILITY FOR ANY INDIRECT,
SPECIAL, INCIDENTAL, CONSEQUENTIAL OR PUNITIVE DAMAGES, HOWEVER CAUSED AND ON
ANY THEORY OF LIABILITY, ARISING OUT OF THE SERVICES OR ANY OTHER SUBJECT MATTER
OF THIS AGREEMENT.
(e) EXCEPT FOR VIOLATIONS OF SECTION 3, IN NO EVENT WILL EITHER PARTY BE LIABLE
UNDER ANY LEGAL OR EQUITABLE THEORY OF LIABILITY FOR ANY DIRECT DAMAGES, HOWEVER
CAUSED, ARISING OUT OF THE SERVICES OR ANY OTHER SUBJECT MATTER OF THIS
AGREEMENT IN EXCESS OF AMOUNT EQUAL TO THE MAXIMUM ANNUAL FEE PAID FOR ANY
CALENDAR YEAR UNDER THIS AGREEMENT.
9.    General Provisions.
(a)    The Parties will perform their obligations under this Agreement as
independent contractors and nothing contained in this Agreement will be
construed to be inconsistent with such relationship or status. This Agreement
will not constitute, create or in any way be interpreted as an employment or
agency relationship or a joint venture or partnership of any kind.
(b)    This Agreement will be governed by the laws of the State of New York, as
such laws are applied to contracts entered into and to be performed within such
state, without regard to any conflicts of laws provisions.
(c)    This Agreement, including Exhibit A and any SOWs executed thereunder, are
intended by the Parties to be one, integrated non-severable set of transactions,
and set forth the entire agreement and understanding between Amyris and TOTAL
relating to the subject matter herein and therein, and supersedes all prior
discussions between the Parties. In the event of a conflict between or among
this Agreement, Exhibit A, an SOW and any other schedule or Exhibit, the
following order of precedence shall govern: Exhibit A, this Agreement, an SOW,
and, if any, all other Exhibits and Schedules. No modification of or amendment
to this Agreement, Exhibit A or any SOW, nor any waiver of any rights

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hereunder or thereunder will be effective unless executed in writing and signed
by both Parties.
(d)    All notices required or given herewith shall be addressed to Amyris or
TOTAL at the designated addresses shown below by registered mail, special
delivery, or by certified courier service:
If to TOTAL:
TOTAL New Energies USA, Inc.
5858 Horton Street
Emeryville, CA, 94608
Attn: Chief Executive Officer
Email: ____________________________
If to Amyris:
Amyris, Inc.
5885 Hollis St, Suite 100
Emeryville, CA 94608
Attn: Legal Department
Email: generalcounsel@amyris.com

(e)    The headings used in this Agreement are for the convenience of the
Parties and for reference purposes only and shall not form a part or affect the
interpretation of this Agreement.
(f)    If one or more of the provisions in this Agreement are deemed void by
law, then the remaining provisions will continue in full force and effect.
(g)    Neither this Agreement nor any right or obligation hereunder or interest
herein may be assigned, delegated, or transferred by either Party by operation
of law or otherwise without the express prior written consent of an officer of
the other Party, provided, however, that (i) either Party may assign this
Agreement upon written notice to the other Party to the purchaser of its entire
business, and (ii) TOTAL may assign or transfer this Agreement to any Affiliate.
This Agreement will be binding upon the assignor’s heirs, executors,
administrators and other legal representatives.
(h)    If any action at law or in equity is necessary to enforce or interpret
the terms of this Agreement, the prevailing Party shall be entitled to
reasonable attorneys’ fees, costs, and necessary disbursements, in addition to
any other relief to which the Party may be entitled.
(i)    Amyris is committed to the provisions outlined in the Equal Opportunity
Clauses of Executive Order 11246, (41 CFR 60-1.4), section 503 of the
Rehabilitation Act of 1973, (41 CFR 60-741.5(a)), section 402 of the Vietnam Era
Veterans Readjustment Act of 1974, (41 CFR 60-250.5(a)), and, the Jobs for
Veterans Act of 2003, (41 CFR 60-300.5(a)) as well as any other regulations
pertaining to these orders.

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IN WITNESS WHEREOF, and intending to be bound by the provisions hereof, the
Parties hereto have caused this Agreement to be executed personally or by their
duly authorized representatives, to be effective as of the Effective Date.

AMYRIS, INC.
TOTAL NEW ENERGIES USA, INC.
Signature:  /s/ John Melo _______________
Signature:_________________________
By: John Melo__________________
By:___________________________________ 
                (print name)
Title: C.E.O.___________________
Title:__________________________________

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IN WITNESS WHEREOF, and intending to be bound by the provisions hereof, the
Parties hereto have caused this Agreement to be executed personally or by their
duly authorized representatives, to be effective as of the Effective Date.

AMYRIS, INC.
TOTAL NEW ENERGIES USA, INC.
Signature:______________________________
Signature:/s/ Denis Giorno
By:___________________________________
By: Denis Giorno 
                (print name)
Title: ____________________________
Title:   President and CEO

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EXHIBIT A
I.OVERVIEW
Pursuant to Section 1 of the Agreement, this Exhibit A describes and sets forth
the terms and conditions under which Amyris shall perform certain Services for
TOTAL as described below and as requested by TOTAL. All capitalized terms used
herein and not otherwise defined shall have the meaning set forth in the
Agreement. For purpose of this Exhibit A, the “OCT Facilities” shall have the
meaning given to it in the Sublease.
II.OPERATING CORE TEAM (OCT) – MANAGEMENT OF THE OCT FACILITIES
a)OCT Personnel. Amyris will designate at least six (6) Amyris employees who
will be exclusively authorized to operate the OCT Facility and perform all
Services hereunder, including executing the Campaigns (as defined below) (the
“OCT Personnel”). Amyris will endeavor to staff the OCT Facility with at least
ten (10) OCT Personnel during the term of the Agreement. Amyris shall ensure
that the OCT Personnel are qualified to use all equipment and tools in the OCT
Facilities required for the performance of the Services. Throughout this Exhibit
A, the term “Amyris Employees” means any and all employees of Amyris that are
not OCT Personnel. Amyris will maintain a list of the names of all OCT Personnel
which can be reviewed by TOTAL on an as-needed basis upon reasonable request.
Amyris will notify TOTAL when it actually replaces an OCT Personnel, identifying
the individual to be replaced and the replacement.
b)OCT Policies. All OCT Personnel will be required to follow a set of policies
(including additional confidentiality restrictions) that apply to performance of
the Services, and each OCT Employee shall acknowledge in writing that he/she has
reviewed, understood and agreed to abide by such policies. Any TOTAL employees
that are being trained as part of the Services or otherwise participating or
observing the Services in the Pilot Plant will need permission of the OCT
Manager to be in the OCT Facilities and will be required to follow the same
policies while in the OCT Facilities, and sign substantially the same
acknowledgement. In addition, Amyris employees executing SOWs on behalf of
Amyris also shall sign agree to such acknowledgement as it applies to the
non-use and nondisclosure obligations described therein. A copy of the policies
is set forth in Schedule 1 hereto. The OCT Personnel shall treat any information
regarding any activities being conducted by TOTAL or any of the Services as
Confidential Information as set forth in the Agreement, and shall not share any
such information, except as set forth in Section 3(b) of the Agreement.
Notwithstanding the foregoing, the OCT Personnel shall not be restricted from
sharing any such information with any Amyris Employees regarding (i) Amyris
activities in the OCT Facilities that are not related to the Services or TOTAL
Confidential Information, or (ii) the scheduling (but not the content or subject
matter) of the Services. In addition, the OCT Personnel may disclose issues of
safety within the Pilot Plant to the appropriate Amyris Employees responsible
for safety and emergency management in the Pilot Plant.

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c)OCT Manager. The OCT Personnel will include one Amyris employee who will serve
as one of the OCT Personnel and will manage the other OCT Personnel and the
Services (the “OCT Manager”). The OCT Manager will be the primary contact for
TOTAL and will represent and be authorized to take all decisions and exercise
authority on behalf of Amyris in performing the Services. The OCT Manager will
be responsible for tracking the OCT Personnel person-hours utilized for the
Services to confirm compliance with the Annual Hours Commitment provided by
Amyris as set forth below, provided that the time spent by the OCT Manager
managing the OCT Personnel or tracking person–hours shall not constitute
Services. For the avoidance of doubt, all OCT Personnel (including the OCT
Manager) are employees of Amyris, reporting to Amyris’s management, shall be
performing the Services as employees of Amyris, and shall not at any time act or
take any action as an agent of TOTAL.
III.SERVICES
a)    Services; Statement of Work (“SOW”); Scheduling. As used in this Exhibit,
“Services” includes the following: (i) training TOTAL employees in the operation
of the Pilot Plant, (ii) conducting and documenting Campaigns (as defined below)
for TOTAL; and (iii) the following “Other Services”: (1) performing other
fermentation and downstream separations scale-up services and such other tasks
which may include the following: recovery operations, seed train fermentation on
[*] and [*] (potentially [*] also) and (2) for the [*] fermenter, preparation
and sterilization of feedstock, preparation and sterilization of media, support
for fermentation operations, support for sterilization and cleaning of equipment
or materials, support for sample analytical preparation as provided in Section
III(e) below. Services will be performed only by OCT Personnel. During the
performance of Services, TOTAL employees shall have access to the OCT
Facilities, including the right to operate the equipment included in the OCT
Facilities under the supervision of the OCT Personnel only while being trained
under Section III(a)(i) above or conducting some Other Services as listed in
Section III(a)(iii) above. For clarity, TOTAL shall have no right to operate any
equipment in the OCT Facilities while Amyris is operating a Campaign for TOTAL.
If TOTAL desires Services, the OCT Manager and a single point of contact
designated by TOTAL (“TOTAL BPP Coordinator”) will jointly determine the
allocation of OCT Personnel person-hours for Services, including the amount of
time spent on training, type of Campaign (e.g., Long Run Campaign or Short Run
Campaign) or any Other Services, and the estimated number of OCT Personnel
person-hours needed during each calendar quarter. The OCT Manager and TOTAL BPP
Coordinator will meet and agree on the schedule for a calendar quarter at least
thirty (30) days prior to the beginning of each calendar quarter. At this
meeting, OCT Personnel person-hours to be expended on Services shall be
allocated for such calendar quarter. The OCT Manager and TOTAL BPP Coordinator
will target to schedule an approximate range between 500 OCT Personnel
person-hours and 1500 OCT Personnel person-hours for the calendar quarter. In
the event that the OCT Manager and TOTAL BPP Coordinator cannot agree on the
schedule and/or associated OCT Personnel person-hours to be expended for a
calendar quarter, the Parties agree to escalate the matter to the Joint
Oversight Team as set forth in Section 7(a) of the Agreement. For the

[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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first year of the Agreement, the Parties will agree on such projected workload
within thirty (30) days after the Effective Date.
For each specific Service, the OCT Manager and TOTAL BPP Coordinator will
execute a SOW detailing the tasks to be performed and the estimated number of
OCT Personnel and person-hours. Once the Services are completed, the OCT Manager
and the TOTAL BPP Coordinator will meet in order to validate the person-hours
duly spent to execute the Service described in the corresponding SOW. The
information included in a SOW shall constitute TOTAL Confidential Information. A
template SOW for use with Campaigns where a farnesene process is included is set
forth in Schedule 5. For Campaigns that do not include a farnesene process and
for Other Services, the Parties agree that to use as much as possible the SOW
template set forth in Schedule 5. In any event, for the Campaigns operated
pursuant to the Technology License, Development, Research and Collaboration
Agreement, the SOW corresponding to such Campaigns shall clearly indicate that
such Campaigns will be operated pursuant to the Collaboration Agreement.
b)    Annual Maximum Number of Hours of Services. In consideration for the
Annual Fee, Amyris shall cause the OCT Personnel to perform up to three thousand
one hundred seventy eight (3,178) person-hours of Services each “Contract Year”
(i.e., the twelve month period commencing on the Effective Date and then again
each anniversary of it thereafter during the Term; such amount being the “Annual
Hours Commitment”). In the event the Services agreed upon by the Parties in any
Contract Year exceeds the Annual Hours Commitment, then TOTAL will be charged
$281.73 for each additional hour of Services. In addition, TOTAL may request
additional OCT Personnel person-hours in any Contract Year at the same rate.
Amyris, in its discretion, can agree to accept the request for additional OCT
Personnel person-hours and such acceptance will be documented in the related
SOW. For clarity, “Services” do not include, and no hours shall be attributed
to, analytical work performed by Amyris unless such work is identified in a SOW,
maintenance of the equipment in the OCT Facilities or any management of OCT
Personnel. The Annual Hours Commitment will be allocated each Contract Year to
the performance of the Services agreed upon by the Parties as set forth herein
and for no other purpose. The OCT Personnel will be required to record their
time used to work on Services separately from their time spent on Amyris
activities. Within 15 days after the end of each Contract Year, the Joint
Oversight Team will determine whether Amyris has completed the Annual Hours
Commitment during such Contract Year. In the event that the Joint Oversight Team
cannot agree on the number of OCT Personnel person–hours expended in such
Contract Year, the Parties agree to escalate the matter as set forth in Section
7(a) of the Agreement. If, in a Contract Year, TOTAL fails to use all of the
Annual Hours Commitment, then the Parties agree that, except under the
circumstances set forth below, TOTAL will not be entitled to receive a refund of
the applicable Annual Fee or a reduction of a future Annual Fee with respect to
those unused person-hours. If the Annual Hours Commitment during any Contract
Year is not met by Amyris as a result of Amyris failure to perform Services as
requested by TOTAL in accordance with the terms of the Agreement, including this
Exhibit and any executed SOWs, and such failure results in Amyris failing to
meet the Annual Hours Commitment, then the Parties agree as follows:

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Failure after Contract Year 1: All unused OCT Personnel person-hours will “roll
over” to Contract Year 2 and will be added to the Annual Hours Commitment for
Contract Year 2.
Failure after Contract Years 2-4: TOTAL will have the choice, at its discretion,
to either (a) roll over any unused OCT Personnel person-hours to the Annual
Hours Commitment for the following Contract Year or (b) reduce the Annual Fee
for such following Contract Year by an amount equal to (i) the number of unused
OCT Personnel person-hours from the previous Contract Year multiplied by (ii)
$281.73, thereby eliminating all existing roll over hours.
Failure after Contract Year 5: Amyris will reimburse TOTAL the pro-rata portion
of the Annual Fee equal to (i) the number of OCT Personnel person-hours that
were unused at the end of Contract Year 5 multiplied by (ii) $281.73.

In addition, in the event the roll over hours OCT Personnel person-hours exceed,
in the aggregate, 1,500 hours at the end of any Contract Year after Contract
Year 1, Amyris will be considered in material breach of the Agreement and TOTAL
may terminate in accordance with Section 6(c) of the Agreement.

c)    Training of TOTAL Employees. As part of the Services, if requested by
TOTAL, Amyris will provide TOTAL employees with training on how to operate
equipment and generally process fermentation campaigns in the Pilot Plant. Most
such training will occur through a “side-by-side” process, where TOTAL employees
first accompany and then perform with supervision from the OCT Personnel, the
tasks of running a Campaign as set forth below. As part of such training
Services, the OCT Personnel shall provide the TOTAL employees access to all
relevant documentation and equipment as needed to complete the Campaign
training, as well as, if requested by TOTAL, access to a farnesene strain to be
used in the fermentation processes to be carried out in such Campaign.
d)    Campaigns.
(i)Definition
If requested by TOTAL under this Exhibit, Amyris will conduct Campaigns (as
defined below) for TOTAL as part of the Services. A “Campaign” is defined by the
completion of all the following steps: feedstock preparation and sterilization,
media preparation and sterilization, flask culture, seed train fermentation,
main fermentation (in fermentors from [*] to [*] capacity), product recovery,
sampling and sample preparation, cleaning and handling, data collection and
analysis, and reporting. For clarity and instance, a Campaign might be either a
“Long Run Campaign” or a “Short Run Campaign”.
A typical Long Run Campaign means a fermentation process in the OCT Facility
that typically includes the steps listed in Schedule 2 hereto. The Parties
estimate will require approximately [*] OCT Personnel person-hours and
associated utilization of equipment in
[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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the OCT Facilities to complete. Such campaign requires [*] of fermentation in
MFA after inoculation. A simplified task schedule starting from the IFA task is
provided on Figure 3 with number of working days per equipment. The red cells
represent the inoculation day and the green ones the harvests days.
[*]
Figure 3 – [*]
A typical Short Run Campaign means a fermentation process in the OCT Facility
that typically requires fewer technical steps and fewer estimated OCT Personnel
person-hours to complete than a Long Run Campaign.
The Parties estimate a Short Run Campaign will typically require approximately
121 OCT Personnel person-hours and associated utilization of equipment in the
OCT Facilities to complete. A simplified task schedule starting from the IFA
task is provided on Figure 4 with number of working days per equipment.

[*]
Figure 4 – [*]

Measuring Success in Campaigns

•Key Parameters. In each SOW, TOTAL and Amyris will define the objectives to be
reached when executing the Campaign. Among those objectives, no more than two
objectives will be identified as “Key Parameters” by the Parties. If the Key
Parameters are met, the Campaign will be considered a “Successful Campaign” and
will be accepted by TOTAL.

•Process. Once the Campaign is terminated (at any time for any reason, including
completion), the TOTAL BPP Coordinator and the OCT Manager shall meet to
evaluate if the results (recorded data, analysis, etc.) are sufficient to meet
the Key Parameters. The decision on whether Key Parameters are met will be at
TOTAL BPP

[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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Coordinator’s discretion. However, if the Key Objectives are not met, an ABGD
System (as defined below) analysis shall be performed by the OCT Personnel and
upon TOTAL’s request, the TOTAL BPP Coordinator (or its designee) shall be
entitled both to participate in such analysis, and to access the conclusions of
the report of such analysis.

•The ABGD System. Amyris operates a batch quality system (the alpha beta gamma
delta or ABGD system) which evaluates each batch by operational execution and
outcome events as the basis for establishing whether a Campaign is a Successful
Campaign. A detailed description of the ABGD system is set forth in Schedule 6.
Alpha-Gamma, Alpha-Delta and Beta-Gamma outcomes will not result in an Attempted
Campaign (as defined below).

•Attempted Campaign. A Campaign that does not meet the Key Parameters at
termination and is categorized as Beta-Delta through the ABGD System is defined
as an “Attempted Campaign”. An Attempted Campaign shall not be deemed a
performance breach by Amyris, and Amyris will not deduct from the Annual Hours
Commitment any OCT Personnel person-hours expended by Amyris on an Attempted
Campaign. Within thirty (30) days after such Attempted Campaign, Amyris shall
re-execute the Campaign, up to a maximum of two additional times, and TOTAL
shall not be charged any additional OCT Personnel person-hours or cost for
concluding such re-executed Campaign. In the event an Attempted Campaign occurs
(up to a maximum of two Attempted Campaigns in a row) and the re-executed
Campaign results in a Successful Campaign, TOTAL will be charged OCT Personnel
person-hours for the Successful Campaign only.
•Failed Campaign. Three Attempted Campaigns on the same Campaign SOW is defined
as a “Failed Campaign”. If three or more Failed Campaigns occur during a twelve
month period, then TOTAL may thereafter terminate this Agreement without cause
pursuant to Section 6(b) without, however, any obligation to pay the amount
specified in Section 6(b) (ii).
•Root Cause Analysis. Amyris shall perform a root-cause analysis of each
Attempted Campaign to identify the operational cause of the failure if
applicable and report such analysis to TOTAL within thirty (30) days after the
date of each Attempted Campaign, and resolve such failure within sixty (60) days
after the basis for such Attempted Campaign has been identified.
e)    Other Services. From time to time TOTAL may request the OCT Personnel to
perform Other Services. If some of the Other Services are to be performed using
equipment in the Total Dedicated Area, the SOW shall identify such equipment.
The OCT Personnel person-hours incurred to perform such Services shall apply
against the Annual Hours Commitment available in the Contract Year. Once an
Other Service is terminated, the TOTAL BPP Coordinator and the OCT Manager shall
meet to evaluate if the results (if any) established in the SOW for such Other
Services have been achieved. The OCT Manager and the TOTAL BPP Coordinator shall
agree on the Key Parameters (if any) and anticipated results to be achieved for
any Other Services on the associated SOW prior to execution of the related
Services. If the results are not achieved, the tasks described in such SOW will
be

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re-executed by the OCT Personnel, TOTAL shall not be charged any additional OCT
Personnel person-hours or cost for concluding such re-executed SOW within thirty
(30) days after such termination.
f)    Right to Lockout. Upon forty (40) days’ prior written notice and up to
four (4) times each Contract Year, TOTAL may inform Amyris that Amyris will not
be allowed to have any non-OCT Personnel visit or occupy the OCT Facilities
during the operation of a specific Campaign or Service. Amyris will have the
same right to exclude TOTAL and any associated employees, guest or partners from
the OCT Facilities for the same number of days each year upon the same notice.
Notwithstanding the foregoing, members of the Amyris emergency response team
will at all times have access to the OCT Facilities in order to respond to any
emergency situations on an as needed basis.
g)    Information Technology. The OCT Facilities equipment will be accessible by
each Party’s respective IT Networks, but it will only be accessible by one
Party’s network at any time. The OCT Manager shall ensure that OCT Personnel
disconnect certain OCT Facilities equipment from one Party’s network and
attaching it to the other Party’s network when shifting from executing a
Campaign to conducting work for Amyris (and vice versa). The OCT Personnel shall
take all actions necessary to ensure that all Campaign data is deleted from any
OCT Facilities equipment prior to reattaching such equipment to the Amyris
network (and vice versa). In the event that a Party inadvertently acquires or is
given access to the other Party’s data residing on OCT Facilities equipment,
such Party shall promptly notify the other Party, shall not use and shall
promptly destroy such data.
IV.DOCUMENTATION
a)    Campaign/Service Report. For each Campaign or Other Service performed by
Amyris, the OCT Personnel will prepare and provide a written report addressing
the items specified in Schedule 3 as altered by mutually agreement of the OCT
Manager and the TOTAL BPP Coordinator, or in the applicable SOW. The OCT Manager
shall deliver such report to TOTAL not later than one (1) month after the end
date designated in such SOW. The OCT Manager shall make the OCT Personnel
involved with such Service reasonably available to answer TOTAL’s questions
generated from review of each report. All time Amyris spends preparing such
reports and subsequently answering questions about such reports will be deducted
from the Annual Hours Commitment. For the avoidance of doubt, such report shall
be deemed to be the property and Confidential Information of TOTAL for the
purposes of this Agreement; however Amyris may keep a reference copy of such
report in accordance with Section 3(d) of the Agreement.
b)    Batch Records. The OCT Personnel shall maintain during the execution of
each Campaign or other Service (as applicable) a batch record (in the form and
including the details specified in the SOW for such Campaign) to keep track of
all events and parameter settings used during the Campaign. Within five (5)
business days after the conclusion of each Campaign or other Service (including
Campaigns and Services terminated prior to completion), Amyris will provide a
copy of the batch record to TOTAL. For the avoidance of doubt, such records
shall be deemed to be the property and

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Confidential Information of TOTAL for the purposes of this Agreement; however
Amyris will keep a reference copy of such records in accordance with its then
current standard record keeping procedures, provided that such copy may only be
used in relation to disputes between Amyris and TOTAL with respect to the
performance of the Campaign or Service (as applicable) that was the subject of
the report.
c)    Raw Data. For each Campaign or other Service performed hereunder, the OCT
Personnel shall maintain the raw data files that are generated by the analysers
and fermenters used for execution of such Campaign or other Service (as
applicable), and shall deliver such raw data files in a format reasonably
requested by TOTAL within five (5) days after the conclusion of each Campaign or
other Service (including Campaigns and Services terminated prior to completion).
For the avoidance of doubt, such raw data files shall be deemed to be
Confidential Information of TOTAL for the purposes of this Agreement; however
Amyris may keep copies of such raw data files in accordance with Section 3(d) of
the Agreement.

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SCHEDULE 1
OCT FACILITIES POLICIES
Amyris and TOTAL have entered into an agreement under which Amyris will provide
fermentation and downstream separations scale-up services as well as training
and related services to TOTAL employees at 5850 Hollis Street, Emeryville,
California (the “Pilot Plant”).

You are one of the Amyris employees who will perform such services at the Pilot
Plant. The services will be performed at the request of TOTAL under the
oversight of Amyris’ Pilot Plant Manager in coordination with TOTAL (TOTAL
manager referred to as the “TOTAL BPP Coordinator”). Employees of TOTAL also
will be using and working in the Pilot Plant.

You will be interacting with TOTAL employees and materials belonging to TOTAL
and may learn about or become exposed to confidential information belonging to
TOTAL or its partners. It also is important to remember that you may possess
confidential information belonging to Amyris or some of its other partners and
need to ensure that you do not disclose this information to the TOTAL employees.

It is important to Amyris and TOTAL that you understand your obligations in
regard to that information. As a consequence, Amyris and TOTAL have established
the following policies to help guard against improper disclosure of confidential
information and to help guide interactions between you and TOTAL employees. Note
that this policy does not affect your obligations to Amyris under your
Proprietary Information and Inventions Agreement. By signing this policy below,
you hereby confirm and agree that:

•
You will only disclose to TOTAL employees information about Amyris projects,
materials or personnel (whether marked “confidential” or “proprietary” or
communicated in oral, written, graphic or electronic form) if you are
specifically instructed to do so by the Pilot Plant Manager.

•
You will not disclose anything you learn about TOTAL’s projects, materials or
personnel (whether marked “confidential” or “proprietary” or communicated in
oral, written, graphic or electronic form) to any Amyris employee or consultant
unless you are specifically instructed to do so by the Pilot Plant Manager.

•
You will comply with all policies and procedures generally governing personnel
working at the Pilot Plant, including Amyris safety policies.

•
If you know or suspect there has been a security or safety incident in the Pilot
Plant, you will report it immediately and directly to the Pilot Plant Manager.

•
You will keep accurate records of any time spent conducting services on each
TOTAL project and will accurately report all such time to the Pilot Plant
Manager by the deadlines and in the form required by the Pilot Plant Manager.

Please see the Pilot Plant Manager if you have any questions related to this
policy.

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Please acknowledge your agreement to the terms of this policy by signing and
dating in the space below and returning the signed copy to the Pilot Plant
Manager.
  
Signature: ______________________________________________________________

Printed Name: _________________________________________________________

Date: ____________________________________________________________________

Acknowledged: TOTAL New Energies USA, Inc.

Signature: _____________________________________________________________

Printed Name and Title: _____________________________________________

Date: ___________________________________________________________________

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SCHEDULE 1A
OCT FACILITIES POLICIES

Amyris and TOTAL have entered into an agreement under which Amyris will provide
fermentation and downstream separations scale-up services as well as training
and related services to TOTAL employees at 5850 Hollis Street, Emeryville,
California (the “Pilot Plant”).

You are one of the TOTAL employees who will be engaged with such services at the
Pilot Plant. The services will be performed at the request of TOTAL under the
oversight of Amyris’ Pilot Plant Manager in coordination with TOTAL (TOTAL
manager referred to as the “TOTAL BPP Coordinator”). Employees of TOTAL also
will be using and working in the Pilot Plant.

You will be interacting with Amyris employees and materials belonging to Amyris
and may learn about or become exposed to confidential information belonging to
Amyris or its partners. It also is important to remember that you may possess
confidential information belonging to TOTAL or some of its other partners and
need to ensure that you do not disclose this information to the Amyris
employees.

It is important to Amyris and TOTAL that you understand your obligations in
regard to that information. As a consequence, Amyris and TOTAL have established
the following policies to help guard against improper disclosure of confidential
information and to help guide interactions between you and Amyris employees.
Note that this policy does not affect your obligations to TOTAL under your
employment contract and/or any policy or agreement issued by TOTAL and
applicable to you concerning proprietary information and inventions management.
By signing this policy below, you hereby confirm and agree that:

•
You will only disclose to Amyris employees information about TOTAL projects,
materials or personnel (whether marked “confidential” or “proprietary” or
communicated in oral, written, graphic or electronic form) if you are
specifically instructed to do so by the TOTAL BPP Coordinator.

•
You will not disclose anything you learn about Amyris’s projects, materials or
personnel (whether marked “confidential” or “proprietary” or communicated in
oral, written, graphic or electronic form) to any TOTAL employee or consultant
unless you are specifically instructed to do so by the TOTAL BPP Coordinator.

•
You will comply with all policies and procedures generally governing personnel
working at the Pilot Plant, including Amyris safety policies.

•
If you know or suspect there has been a security or safety incident in the Pilot
Plant, you will report it immediately and directly to the TOTAL BPP Coordinator.

Please see the TOTAL BPP Coordinator r if you have any questions related to this
policy.

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Please acknowledge your agreement to the terms of this policy by signing and
dating in the space below and returning the signed copy to the TOTAL BPP
Coordinator.
  
Signature: ______________________________________________________________

Printed Name: _________________________________________________________

Date: ____________________________________________________________________

Acknowledged: Amyris, Inc.

Signature: _____________________________________________________________

Printed Name and Title: _____________________________________________

Date: ___________________________________________________________________

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SCHEDULE 2
FARNESENE LONG RUN CAMPAIGN STEPS AND PROJECTED TIME

Task Name
OCT hours
[*]
[*]

[*]
[*]

[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
[*]
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[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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[*] Certain portions denoted with an asterisk have been omitted and filed
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has been requested with respect to the omitted portions.

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[*] Certain portions denoted with an asterisk have been omitted and filed
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has been requested with respect to the omitted portions.

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[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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[*] Certain portions denoted with an asterisk have been omitted and filed
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has been requested with respect to the omitted portions.

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[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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SCHEDULE 3
CAMPAIGN REPORT REQUIREMENTS
Each Campaign report will address the following subject areas (provided that the
Parties may adjust the subject areas for a particular Campaign and capture the
new Campaign Report Requirements in the SOW for such Campaign or as mutually
agreed) in detail reasonably acceptable to TOTAL:

•
Report Executive Summary (Summary of the main observations, results and
conclusions)

•
Overview (Recap of the main objectives of the campaign including the Key
Parameters, recall of main process conditions including strain and feedstock
used)

•
Experimental Plan (Recap of the original experimental plan and comparison with
experiments actually performed, it could be a table with the main process
conditions that has been varied along the Campaign + the main process fixed
conditions that are of importance) :

◦
Varied process parameters

◦
Main fixed parameters

◦
Description of the adjustments Made between the original and the actual plan

•
Experiment Chronology (Date and runtime of each activity (e.g. inoc transfer,
draw, addition) with short description of activity including quantities and OD
measurement when applicable, and main critical observation / operating issue
when applicable)

•
Process Description (including material and methods / Protocols used)

o
Sterilization (e.g. Feedstock composition, set up conditions)

o
Seed train (e.g. for each step : Vessel Size and type, Post-Inoc Volume, Volume
of Innoc, Harvest OD, Feed composition, Media composition, Fermentation recipe)

o
Fermentation (e.g. Vessel Size and type, Post-Inoc Volume, Volume of Inoc, Feed
composition, Media composition, Fermentation recipe, Antifoam, PH control, Air
flowrate & OTR, agitation, Pressure, Feed strategy)

o
Downstream processes Operating Conditions

▪
L/S setup conditions if applicable

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▪
L/L setup conditions if applicable

▪
Polishing setup conditions if applicable

▪
Or any others setup conditions in case of a different recovery unit operation
than centrifugation

o
Sampling Plan (Identification of all samples taken and their frequency, and
results acquired during all the steps of the Campaign, either captured on the
batch record or in an electronic format)

o
Analytical Plan (SOP used for sample preparation, SOP used for analytical work)

o
Formulas Used for Calculation (Yield and mass balances)

•
Results (one paragraph by Step or Process section)

◦
Sterilization (e.g. Composition, Brix analysis, Vapor consumption, Temperature
profile)

◦
Fermentation (e.g. with MFCS profile for OTR, OUR, Temp, pH, RQ, Press, Residual
Sugar, EtOH, Volume, Product titers )

◦
Downstream (e.g. capillary assay results, titers results in the broth and each
stream along the recovery process, Centrifuges heavy and discharge phases if
applicable)

◦
Mass Balances in case a template is provided in the SOW (For each draw : global
and fene balance)

◦
Yields Calculation in case a template is provided in the SOW (e.g. Product
yield, Productivity, L/S yield if applicable, L/L yield if applicable, Recovery
Yield)

◦
Operational Observations

◦
Batch record and/or any others raw data files attached to the report)

•
Data Analysis (If applicable and described in the SOW)

•
Conclusions and Recommendations on an operational standpoint

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SCHEDULE 4
HSE STANDARDS

1. The Company's safety plans include, but are not limited to:

a. Ergonomics
b. Personal Protective Equipment (PPE)
c. Hazardous Waste Management
d. Radiation Safety
e. Chemical Hygiene Plan (CHP)
f. Biological Safety
g. Emergency Action Plan/Fire Prevention Plan
h. Risk Assessment Procedures
i. Safe Operating Guidelines (SOGs)
j. Lockout/tagout
k. Safety Orientation
l. Emergency Response
m. Hearing Conservation
n. Respiratory Protection
o. Contractor Safety
p. Contract Manufacturing Safe Operations

2. Training
a. OCT Personnel and TOTAL Employees

Amyris has established a program of training for all OCT Personnel and TOTAL
employees so that they will be aware of the hazards and potential hazards.
Training will be conducted by Amyris’ safety program administrator, the OCT
Manager, knowledgeable and qualified Amyris employees, or outside consultants.
The training may either be carried out in a classroom or through an online
system. A schedule for various types of training can be obtained by contacting
the OCT Manager.

All OCT Personnel and TOTAL Employees are required to attend mandated Amyris
training sessions and meetings and to read and comply with Amyris notices,
warnings, and memos/emails, if applicable.

3. Training Schedule

a. Initial Training.

OCT Personnel and TOTAL Employees will receive safety training prior to being
granted access to the OCT Facilities.

b. Previously Unrecognized Hazards.

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OCT Personnel and TOTAL Employees shall receive additional training whenever a
previously unrecognized potential hazard is identified or, for example, when new
or different information is given on a Material Safety Data Sheet.

c. Emergency Training.

OCT Personnel and TOTAL Employees shall receive training in Emergency
Action/Fire Prevention Program. In addition, certain OCT Personnel and TOTAL
Employees may receive first aid/CPR training as needed.
d. Potentially Hazardous Non-Routine Tasks.

OCT Personnel and TOTAL Employees shall receive training and/or information
before potentially hazardous non-routine tasks are undertaken. Depending on the
circumstances, this training may be included in a regularly scheduled training
session by the OCT Manager or through a task safety analysis or process safety
review.

e. Annual Training.

Certain training such as biological, chemical, ergonomic and radiation safety
will be done annually, as needed.

4. Training Records

a. Safety related training sessions will be documented using an Amyris training
list sign-up sheet, highlighting the class. The Amyris training list sign-up
sheet should give the name of the training class, the date and time of the
session, and the name and signature of the OCT Personnel or TOTAL Employee.

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SCHEDULE 5
SOW TEMPLATE
The SOW should include the following:
•
Objectives

•
Key Parameters identified with acceptable deviation range as the trigger to
qualify the failure of the Campaign (Alpha – Beta qualification)

•
Recall of the main process description and parameters

•
Expected results from smaller scale extrapolation

•
Materials to be used for each process step, including Protocols / SOP applicable
(equipment, sample preparation, etc.)

•
Description of the work:

◦
Synoptic

◦
Process description for each process step if applicable

◦
Operating conditions for each process step (including if applicable a mention
for Fixed Parameters vs Variables)

◦
Data to be recorded with a template of a Batch Record if applicable

◦
Sampling strategy

◦
Analytical strategy

◦
Performances expected

◦
Special requests

•
A template for Data analysis, calculations, graphs plotting, if applicable

•
Formulas for calculation, if applicable

•
Content of the Campaign Report (and graphs to be plotted)

•
Timing/Scheduling of the Campaign

•
Estimated person-hours for the performance of the Campaign

•
OCT Personnel responsible for the performance of the Campaign

•
Safety constraints and Emergency Response Team in place

Every SOW must be signed by both the TOTAL BPP Coordinator and the OCT Manager
prior to execution in order to be valid. The Parties agree to use as much as
possible the template set forth below:

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SOW Form Request
Amyris/Total under Pilot Plant Services Agreement

Date
 
Requester
 
Estimated person-hours
 
OCT Personnel responsible
 
Signatures
TOTAL
Amyris
Name:
Signature
Date
Name:
Signature
Date

--------------------------------------------------------------------------------

Main Objectives of the Run:
Strain performance, recovery performance, samples production, robustness……
Purpose:
Description:
Strain number:
Feedstock:

Training Run: □Yes □No
Biofene Program: □Yes □No

--------------------------------------------------------------------------------

1.
Fermentation Step

1.1.
Preparation

 
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[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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1.2.
Fermentation Culture Conditions

Parameter
Unit
Value
Acceptable deviation range (if applicable)
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[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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1.3.
Performances expected

Yield, growth rate, feed, OUR, lab scale graph

1.4.
Special Requests - Comments :

What we need to focus on, issues that can happen

2.
Recovery Step

2.1.
Parameters for L/S separation

Equipment: Alfa-Laval DX203 centrifuge
Parameter
Standard
Required
Fene
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[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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[*]

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*The pump speed will be adjusted to maintain the split ratio closed to the
target.
Comments / Special requests:

2.2.
Parameters for L/L separation

Please choose:
a)
Alfa-Laval LAPX404

b)
Gyro

If LAPX chosen:
Parameter
Standard
Required
Fene
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Comments / Special requests:

If a surfactant is required, please specify:
•
Type:

•
Concentration:

•
Mixing type and time:

 
2.3.
Parameters for polishing

Please choose:
a)
Alfa-Laval DX203

b)
Filtration

If DX203 is chosen:
Parameter
Standard
Required
Fene
[*]

[*]

 

[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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Comments / Special requests:

If Filtration is chosen, describe the set-up and type of filters.

If a stabilizator is added, please specify:
•
Type:

•
Concentration:

3.
Storage of Crude Products

How:
Where:
Duration:

If no polishing is done on the crude product, please specify if stabilizator
addition is required:
•
Type:

•
Concentration:

4.
Analytics

Please review our standard analysis, and add comments or precisions if required.
 
Feedstock
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Daily Fermentation
 
IFA, SFA
MFA
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[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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5.
Data Reporting

6.
Special Samples and Requests

[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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SCHEDULE 6
THE ABGD SYSTEM
Amyris Fermentation Process Quality Assignment – ABGD (αβγd) System

Background
The ABDG system is an acronym for Alpha (correct execution), Beta (incorrect
execution), Gamma (meets specifications), Delta (Failed specifications). It is a
data classification tool that identifies correct process control and
experimental data sets. The purpose of applying the tool is to enable
calculation of operational performance (control) and process robustness
(capability). The system provides clarity across a number of projects, programs,
and facilities.

Application of ABDG
Fermentation processes are performed by following a set of instructions. These
instructions are in the form of written description in the scope of work. The
instructions must include the key process variables and their target set points,
acceptable ranges, and concern limits. The key parameters are monitored
throughout the process and any deviations are noted. This assessment may be
manual or be automated. In Amyris’s fermentation lab and pilot plant we are
operating mainly an auto tagging system that is based on the MFCS process
control system measurements and the process parameter targets. There are also a
small number of manual assessments that are inputted by the operations team.
These operational events or discrepancies in execution, or deviations from
target, are referred to as tags.

In addition to the operational execution tagging there is a further level of
assessment of the batch outcomes. This evaluates the ability of the method
executed to deliver data and product quality that is within agreed range
according to the specifications. The overall system is illustrated in Figure 1.

[*]

[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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Figure 1: Categorization of process quality

In summary an alpha lot is a batch that has the following basic elements:-
•
Equipment was set up correctly

•
The correct raw materials were used

•
The process operations were conducted correctly

•
No mechanical issues

Beta lots would be batches that exhibit the following elements:-
•
Contamination

•
Excursions from set points

•
Noisy measurements leading to poor control

•
Equipment or electronic failures

•
Utility failures leading to excursions

Setting Rules and Specifications
Process operational and outcome rules are listed and agreed through a review
process. The review requires sign off from fermentation managers and project/
program stakeholders. The agreed rules sets and specifications are recorded in a
versioned controlled document. By way of illustration only, Table 1 shows the
typical listing of rules for alpha/beta and delta assignments:

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Level
Set
Version
Current
Speciation Name
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Table 1 Summarization of Rule Sets

[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

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Typical examples of beta delta events would be contamination resulting from
operator error, process control failures, and incorrect media or batch recipe if
the run request was not properly. For clarity, it is understood that the
specific parameters to determine/define the ABDG status of a batch should be
defined on a case by case basis and reviewed within the Scope of Work process
Assignment
A batch would be assigned a status once all the parameters have been assessed.
The alpha/ beta assignment is completed by the OCT manager. The gamma/ delta
specification assignment is made by the TOTAL BPP coordinator. Final assessment
of the batch as gamma or delta requires completion of process assays and quality
review of the data. Table 2 provides a summary of the four categories that are
assignable:

Categorization
Description
Example
[*]

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Table 2: Assignment of ABDG

Follow Up
The goal is to minimize the beta-delta rate to less than [*]. Beta-delta
operational events are categorized by failure type in a Pareto analysis. A root
cause analysis (RCA) process is performed on the major failure events to
establish the basis for corrective and preventative action (CAPA). The impact of
CAPA is monitored by measuring and comparing the frequency of that event over
time. This is the process of continuous improvement.

[*] Certain portions denoted with an asterisk have been omitted and filed
separately with the Securities and Exchange Commission. Confidential treatment
has been requested with respect to the omitted portions.

GDSVF&H\1814591    Page 46 of 46     CONFIDENTIAL