EXHIBIT 10.1
AMENDMENT 1
To
MANUFACTURING AND SUPPLY AGREEMENT
Between
ALTUS PHARMACEUTICALS INC.
And
LONZA LTD.
          THIS AMENDMENT NO. 1 (the “Amendment”) effective as of June 30, 2008
(the “Effective Date”), is between by and between Altus Pharmaceuticals Inc., a
Delaware corporation with its principal place of business located at 640
Memorial Drive, Cambridge, MA 02139 (“Altus”), and Lonza Ltd, a Swiss
corporation having offices at Muenchensteinerstrasse 38, CH-4002 Basel,
Switzerland (“Lonza”). Each of Altus and Lonza may be referred to herein
individually as a “Party” and collectively as the “Parties”. All capitalized
terms not defined in this Amendment shall have the same meaning as in the
Agreement (defined below).
          WHEREAS, Altus and Lonza are parties to a Manufacturing and Supply
Agreement entered into as of November 16, 2006 (the “Agreement”); and
          WHEREAS, the parties wish to amend the Agreement (i) to provide for
the [***] of [***] obligation to [***] in [***] and (ii) to [***] the [***] upon
which [***] will provide an [***] in [***] for Bulk Product Components to be
manufactured in [***].
          NOW, THEREFORE, in consideration of the premises contained herein and
other valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, the parties hereto agree as follows:

1.   In the event that Lonza and a [***] a [***] or a [***] to [***] and/or
[***] at least a [***] in each of [***] and [***] in [***] (such [***] to begin
approximately during the [***] of [***], the Parties agree that [***] obligation
[***] the [***] of [***] and the [***] of [***] in [***], as set forth in
Section 3.3 of the Agreement is hereby [***] until [***] (the “[***]”). Such
[***] shall be added to [***] obligations to [***] in [***]. In addition, [***]
shall have [***] under Section 6.2(c) to [***] the [***] associated with such
[***].   2.   The Parties agree that Altus may provide the [***] due in the
[***] of [***] on [***] instead of on [***].   3.   Upon execution, this
Amendment 1 shall be made a part of the Agreement and shall be incorporated by
reference. Except as provided herein, all other terms and conditions of the
Agreement shall remain in full force and effect.

[Signatures appear on the following page]
Portions of this Exhibit are omitted and have been filed separately with the
Secretary of the Commission
pursuant to the Registrant’s application requesting confidential treatment under
Rule 24b-2 of the Exchange Act.

 

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          IN WITNESS WHEREOF, the parties hereto have executed or caused this
Amendment No. 1 to be executed by their respective officers or other
representatives duly authorized.

              Altus Pharmaceuticals Inc.   Lonza Ltd
 
           
By:
  /s/ Jill E. Porter   By:   /s/ Thomas Keppler
 
           
 
           
Name:
  Jill E. Porter   Name:   Thomas Keppler
 
           
 
           
Title:
  Vice President, Process Development   Title:   Head of Patent Department
 
           
 
           
Date:
  July 24, 2008   By:   /s/ Yves Kesch
 
           
 
           
 
      Name:   Yves Kesch
 
           
 
           
 
      Title:   Legal Counsel
 
           
 
           
 
      Date:   17 July 2008
 
           

-2-

Portions of this Exhibit are omitted and have been filed separately with the
Secretary of the Commission
pursuant to the Registrant’s application requesting confidential treatment under
Rule 24b-2 of the Exchange Act.