EXHIBIT 10.36.1
AMENDMENT
          AMENDMENT (this “Amendment”), dated as of November 30, 2010, to the
Credit Agreement, dated as of July 14, 2006 (as amended, restated, supplemented
or otherwise modified, this “Agreement”), among GENZYME CORPORATION, a
Massachusetts corporation (the “Parent Borrower”), the SUBSIDIARY BORROWERS (the
“Subsidiary Borrowers”), the several banks and other financial institutions or
entities from time to time parties to this Agreement (the “Lenders”), the
Syndication Agent, Co-Documentation Agents and Co-Agents named therein, and
JPMORGAN CHASE BANK, N.A., as administrative agent. The parties hereto agree as
follows:
WITNESSETH:
          WHEREAS, the Borrower has requested that certain provisions of the
Agreement be amended as set forth herein; and
          WHEREAS, the Administrative Agent, the Issuing Bank and the Required
Lenders are willing to consent to such amendments on the terms set forth herein;
          NOW THEREFORE, in consideration of the premises and mutual covenants
contained herein, the undersigned hereby agree as follows:
          I. Defined Terms. Terms defined in the Agreement and used herein shall
have the meanings given to them in the Agreement.
          II. Amendment to Section 1.1 (Defined Terms). Subsection 1.1 of the
Agreement is hereby amended by adding the following new definition to appear in
alphabetical order:
“Consolidated Total Assets”: the consolidated total asset value of the Parent
Borrower and its Subsidiaries as reported in the Parent Borrower’s most recent
annual report on Form 10-K filed with the SEC under the Securities Exchange Act
of 1934.
          III. Amendment to Section 7.5 (Disposition of Property).
Section 7.5(h) of the Agreement is hereby amended by deleting “fair market value
not to exceed 15% of Consolidated Net Worth in the aggregate” therefrom and
inserting in lieu thereof “net book value not to exceed 10% of Consolidated
Total Assets in any fiscal year”.
          IV. Conditions to Effectiveness of Amendment. This Amendment shall
become effective on the date on which the following conditions precedent have
been satisfied or waived (“Effective Date”):

  (a)   The Administrative Agent shall have received a duly executed counterpart
to this Amendment from the Borrower, the Administrative Agent, the Issuing Bank
and the Required Lenders under the Agreement.     (b)   The Administrative Agent
shall have received payment of all of its reasonable and documented
out-of-pocket costs and expenses incurred in connection with this Amendment, any
other documents prepared in connection herewith and the transactions
contemplated hereby, including, without limitation, the reasonable fees and
disbursements of counsel to the Administrative Agent.

          V. Representations and Warranties. The Borrower hereby represents and
warrants that (a) each of the representations and warranties in Section IV of
the Agreement shall be, after giving

 

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effect to this Amendment, true and correct in all material respects as if made
on and as of the Effective Date (unless such representations and warranties are
stated to relate to a specific earlier date, in which case such representations
and warranties shall be true and correct in all material respects as of such
earlier date) and (b) after giving effect to this Amendment, no Default or Event
of Default shall have occurred and be continuing.
          VI. No Other Amendments; Confirmation. Except as expressly amended
hereby, the provisions of the Agreement and each of the other Credit Documents
are and shall remain in full force and effect.
          VII. GOVERNING LAW. THIS AMENDMENT AND THE RIGHTS AND OBLIGATIONS OF
THE PARTIES HERETO SHALL BE GOVERNED BY, AND CONSTRUED AND INTERPRETED IN
ACCORDANCE WITH, THE LAW OF THE STATE OF NEW YORK.
          VIII. Counterparts. This Amendment may be executed by one or more of
the parties hereto on any number of separate counterparts, and all of said
counterparts taken together shall be deemed to constitute one and the same
instrument. This Amendment may be delivered by facsimile transmission of the
relevant signature pages hereof.
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          IN WITNESS WHEREOF, the undersigned have caused this Amendment to be
executed and delivered by their proper and duly authorized officers as of the
day and year first above written.

            GENZYME CORPORATION
      By:   /s/ Michael S. Wyzga         Name:   Michael S. Wyzga       
Title:   Executive Vice President Finance, Chief Financial Officer       
GENZYME GLOBAL S.A.R.L.
      By:   /s/ Christopher Jenner         Name:   Christopher Jenner       
Title:   Class B Manager              By:   /s/ Nathalie Joannes         Name:  
Nathalie Joannes        Title:   Class A Manager              By:   /s/ Michael
S. Wyzga         Name:   Michael S. Wyzga        Title:   Class A Manager     

 

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            JPMORGAN CHASE BANK, N.A., as Administrative
Agent and as a Lender
      By:   /s/ Peter M. Killea         Name:   Peter M. Killea        Title:  
Vice President        BANK OF AMERICA, N.A., as Syndication Agent and as
a Lender
      By:   /s/ Zubin R. Shroff         Name:   Zubin R. Shroff        Title:  
Vice President     

 

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            The Bank of New York Mellon
      By:   /s/ Clifford A. Mull         Name:   Clifford A. Mull       
Title:   First Vice President     

 

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            The Governor & Company of the Bank of Ireland
      By:   /s/ Anne Donovan         Name:   Anne Donovan        Title:  
Authorised Signatory              By:   /s/ John Goggin         Name:   John
Goggin        Title:   Authorized Signatory     

 

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            Intesa Sanpaolo S.p.A.-New York Branch
      By:   /s/ Luca Sacchi         Name:   Luca Sacchi        Title:   VP     
        By:   /s/ Francesco DiMario         Name:   Francesco DiMario       
Title:   FVP, Credit Manager     

 

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            KBC Bank N.V.
      By:   /s/ Tim Lee         Name:   Tim Lee        Title:   Director       
      By:   /s/ S. Kurtz Barkley         Name:   S. Kurtz Barkley       
Title:   Managing Director     

 

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            RBS Citizens, NA
      By:   /s/ Cindy Chen         Name:   Cindy Chen        Title:   Senior
Vice President     

 

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            The Royal Bank of Scotland N.V.
(formerly known as ABN AMRO Bank N.V.)
      By:   /s/ Michele Costello         Name:   Michelle Costello       
Title:   Director     

 

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            Sovereign Bank
      By:   /s/ Pierre A. Desbiens         Name:   Pierre A. Desbiens       
Title:   AVP     

 

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            WELLS FARGO BANK, N.A.
      By:   /s/ Scott Santa Cruz         Name:   Scott Santa Cruz       
Title:   Director