QuickLinks -- Click here to rapidly navigate through this document

Exhibit 10.32

ASSIGNMENT OF LEASE

    THIS ASSIGNMENT (the "Assignment"), dated as of this 27th day of March,
2001, is made between Shaman Pharmaceuticals, Inc., a Delaware corporation,
("Assignor") and Tularik Inc., a Delaware corporation ("Assignee"), with
reference to the following:

RECITALS:

    WHEREAS, Assignor is the tenant under that certain Industrial Lease
Agreement dated January 1, 1993, as amended with Grand/Roebling Investment
Company ("Landlord") for the premises located in the City of South San
Francisco, County of San Mateo, State of California, commonly known as 213 East
Grand Avenue, 217 East Grand Avenue, 317 Roebling Road, and 333 Roebling Road
(the "Premises");

    WHEREAS, Assignor desires to assign all its right, title and interest in the
Lease to Assignee under the terms and conditions set forth in Stipulation
Regarding Assumption and Assignment of Lease by and among Assignor, Assignee and
Landlord (the "Stipulation") filed with the Bankruptcy Court for the Northern
District of California in Debtor's Chapter 11 reorganization bankruptcy case
(the "Court"); and

    WHEREAS, the Stipulation and this Assignment have been approved by an order
of the Court (the "Order");

    NOW, THEREFORE, in consideration of the mutual covenants and conditions
contained herein, the payment of the amounts and performance of the obligations
set forth in the Stipulation, and other good and valuable consideration, the
receipt and sufficiency of which is hereby acknowledged, the parties agree as
follows:

    1.  Assignment and Assumption. This Assignment shall take effect on the
later of March 26, 2001 or the eleventh (11th) calendar day following entry of
the Order, which Order has not been stayed or reversed during the ten days
following its entry (the "Effective Date"). On the Effective Date, Assignee
shall pay to Assignor the Debtor's Proceeds set forth in the Stipulation;
Assignee shall pay to Landlord the amounts required by paragraph 2 of the
Stipulation; Assignee (as tenant) and Landlord (as landlord) shall execute and
deliver to one another an amendment to the Lease consistent with the
Stipulation; and Assignor shall deliver possession of the Premises to Assignee,
subject only to those listed on Schedule 1 attached hereto. Except for the
existing $128,080 security deposit on deposit with Landlord (which amount has
been forfeit to Landlord by Assignor), Assignor assigns and transfers to
Assignee all its right, title and interest in the Lease; and except as otherwise
set forth in the Stipulation, Assignee accepts the assignment and assumes and
agrees to perform as a direct obligation to Landlord, all the provisions of the
Lease to the extent relating to events occurring from and after the Effective
Date and the obligations assumed by Assignee in paragraphs 4 and 5 of the
Stipulation, except for Assignor's Responsibilities under paragraph 2 below and
except as expressly modified in the Stipulation. From and after the Effective
Date, Assignor shall have no obligations under the Lease, except as set forth in
the Stipulation and the next paragraph.

    2.  Assignor Responsibilities. In addition to its obligations under the
Stipulation, Assignor hereby agrees to indemnify, defend, protect and hold
Tularik and Landlord harmless from and against (a) any claim for payment of any
fees or commissions to any real estate broker or agent in connection with the
Assignment (including, without limitation, any fees or commissions to any real
estate broker or agent payable by Tularik in connection with the Assignment) or
any sublease entered into by Debtor or any brokers agreement entered into by
Debtor, (b) any claim by any subtenant at the Premises for return of any rent
security deposits and pre-paid rent under any subleases collected by Assignor
with respect to subleases of portions of the Premises; and (c) any claim by any
subtenant at the Premises for return of any earnest money deposits collected by
Assignor during Assignor's bankruptcy proceeding.

--------------------------------------------------------------------------------

    3.  Sublease Back. Beginning on the Effective Date, and for a term of six
months thereafter, Assignee shall sublease back to Assignor, rent free, and will
allow Assignor to remain in possession of, approximately 3,000 square feet of
laboratory space and 2,000 square feet of warehouse space, such space to be
mutually agreed by the Assignor and Assignee prior to the Effective Date
pursuant to a separate written agreement to be executed by Assignor and
Assignee.

ASSIGNOR:   ASSIGNEE:
Shaman Pharmaceuticals, Inc.,
a Delaware corporation
 
Tularik Inc.,
a Delaware corporation
By:
 
/s/ STEVEN R. KING   

--------------------------------------------------------------------------------

 
By:
 
/s/ WILLIAM J. RIEFLIN   

--------------------------------------------------------------------------------

Title:
 
Chief Operating Officer

--------------------------------------------------------------------------------

 
Title:
 
Executive Vice President

--------------------------------------------------------------------------------

Date:   March 28, 2001

--------------------------------------------------------------------------------

  Date:   March 28, 2001

--------------------------------------------------------------------------------

--------------------------------------------------------------------------------

LANDLORD'S CONSENT

    The undersigned, as landlord under the Lease referenced in the attached
Assignment, does hereby consent to the Assignment under the terms and conditions
set forth in the Stipulation, together with the following terms and conditions:

1.No Waiver. Landlord's consent shall not be deemed to be a waiver of any
restrictions contained in the Lease concerning further assignment, subleasing or
hypothecation of the Lease.

2.Broker Fees and Sublease deposits. Assignor hereby agrees to indemnify,
defend, protect and hold Landlord harmless from and against (a) any claim for
payment of any fees or commissions to any real estate broker or agent in
connection with the Assignment, (b) any claim by any subtenant at the Premises
for return of any rent security deposits under any subleases collected by
Assignor with respect to subleases of portions of the Premises; and (c) any
claim by any subtenant at the Premises for return of any earnest money deposits
collected by Assignor during Assignor's bankruptcy proceeding.

LANDLORD:        
Grand/Roebling Investment Company,
a California limited partnership
 
 
 
 
By:
 
/s/ J. STANLEY MATTISON   

--------------------------------------------------------------------------------

J. Stanley Mattison
Its: general partner
 
 
 
 
ASSIGNOR:
 
 
 
 
Shaman Pharmaceuticals, Inc.
a Delaware corporation
 
 
 
 
By:
 
/s/ STEVEN R. KING   

--------------------------------------------------------------------------------

Name: Steven R. King
Its: Chief Operating Officer
 
 
 
 

--------------------------------------------------------------------------------

QuickLinks

Exhibit 10.32