EXHIBIT 10.17
 
cbmx
COMBIMATRIX
CORPORATION

6500 Harbour Heights Pkwy
Muklteo, WA 98275

Tel 425.493.2000
Fax 425.493.2010

www.combimatrix.com

Via Overnight Courier
25 March 2003
Stefan Willemsen
Roche Diagnostics GmbH
Nonenwald 2
82377 Penzberg
Germany

First Addendum to Roche/CBMX Research and Development Agreement

Dear Stefan:
As we discussed, we need to update Annex I in the current R&D Agreement to
update the project milestones and priorities of the Committee and to add in
completed milestones for the sake of completeness.

Please sign both copies of this letter with a revised Annex I to substitute in
the revised Annex I.

Sincerely,
Combimatrix Corporation
 
/s/ Jeff Oster
 
Jeff Oster
Sr. Vice President for Intellectual Property

Agreed to substitute revised Annex I
Roche Diagnostics GmbH
 
/s/ Stefan Willemsen

Stefan Willemsen
 

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Annex I
Development Program and Payment Schedule

A  1 K System
        
 

 Product  Due Date  Deliverable
Milestone Payment 
In Mio US $
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* Omitted pursuant to a request for confidential treatment. The omitted material
has been filed separately with the SEC.

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* Omitted pursuant to a request for confidential treatment. The omitted material
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B

10 K System and other development projects

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* Omitted pursuant to a request for confidential treatment. The omitted material
has been filed separately with the SEC.