Exhibit 10.1

AMENDED and RESTATED
EMPLOYMENT AGREEMENT

     THIS AMENDED and RESTATED EMPLOYMENT AGREEMENT, dated February 11, 2005,
supersedes and replaces in its entirety the Employment Agreement entered by and
among CHRONIMED INC., a Minnesota corporation (the “Company”), and Anthony J.
Zappa (the “Employee”), dated March 1, 2003.

     1. Engagement. The Company agrees to employ the Employee and the Employee
accepts such employment on the terms and conditions set forth in this Agreement
and, except to the extent superceded by this Agreement, subject to those
policies and procedures applying to the employees of the Company, as may be
amended from time to time. The Employee shall apply his best efforts and devote
substantially all of his time and attention to the Company’s affairs. Employee’s
title within the Company shall be Executive Vice President, Operations. Employee
shall perform those duties as may from time to time be assigned to him
consistent with the offices held by Employee.

     2. Compensation. As consideration for the covenants and agreements herein
and Employee’s services rendered, the Company shall provide Employee the
following compensation:

     A. Base Salary. The Employee shall be paid an annual base salary of
$230,000.00 during the term of this Agreement, with increases if any as
determined by the Company’s Board of Directors, payable on the 15th and last day
of each month by direct deposit to a bank account designated by Employee.

     B. Bonus. The Employee shall participate in a Company management incentive
compensation plan, commencing with a plan applicable to the Company’s fiscal
year beginning July 1, 2002, which is designed to offer employee the potential
for an annual bonus targeted at 40% of base salary and up to 60% of base salary.
Employee shall meet with the Company’s Chief Executive Officer to establish
qualitative and quantitative initiatives and objectives for the purpose of
assessing the amount of bonus to be paid Employee at the end of the bonus
period.

     C. Stock Options and Incentives. Employee shall be eligible to participate
in annual stock options and incentives consistent with option and incentive
plans made available to the management of the Company and pursuant to the
Company’s Board of Director’s discretion. The terms of future stock options or
incentives, including the number of shares available, exercise price, and
vesting provisions shall be determined pursuant to each option or incentive
agreement.

     D. Employee Benefit Plans, Insurance, and Time-Off. During the term of his
employment, Employee shall be entitled to participate in any employee benefit
plan or plans established and maintained by the Company for comparable

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employees, in accordance with the eligibility requirements and other terms and
provisions of such plan or plans. Employee acknowledges and agrees that the
Company is under no obligation to Employee to establish or maintain any employee
benefit plan in which Employee may participate, and that the terms and
provisions of any employee benefit plan of the Company are matters solely within
the exclusive province of the Board of Directors. Employee shall be entitled to
receive health, life, and disability insurance coverage on terms consistent with
the Company’s insurance offerings to comparable employees. Employee shall
receive vacation and medical time-off pursuant to the Company’s standard
employee policies.

     3. Term and Termination. The term of this Agreement shall commence on
February 1, 2003, and shall continue thereafter until terminated according to
this Section 3. This Agreement shall earlier terminate upon the occurrence of
any of the following:

     A. Written agreement of the parties to terminate;

     B. Employee’s death or Employee’s eligibility for and receipt of long-term
disability benefits under a Company sponsored plan of disability insurance;

     C. Following 45 days written notice by one party to the other indicating
the party’s intention to terminate without cause; or

     D. Termination by the Company for Cause. Cause shall be defined as (i)
Employee’s gross negligence or willful misconduct in the performance of
Employee’s duties; (ii) the commission by Employee of any criminal act, act of
fraud or dishonesty by Employee related to, or in connection with his employment
by the Company, or conviction of a crime for which a sentence of more than 90
days incarceration may be imposed; or (iii) Employee’s persistent failure to
meet the reasonable expectations of or duties consistent with the office held by
Employee.

     E. Change of Control, if the Change of Control Date occurs on or before
June 14, 2005.

  (i)   Definitions. For purposes of this Agreement, “Change of Control” shall
be defined as follows:     a.   When, subsequent to the effective date of this
Agreement, any “person” as defined in Section 3(a)(9) of the Securities Exchange
Act of 1934, as amended (the “Securities Exchange Act”), as used in Sections
13(d) and 14(d) thereof, including a “group” as defined in Section 13(d) of the
Securities Exchange Act, but excluding the Company or any subsidiary or parent
or any employee benefit plan sponsored or maintained by the Company or any
subsidiary or parent (including any trustee of such plan acting as trustee),
directly or indirectly, becomes the “beneficial owner” (as defined in Rule 13d-3
under the Securities Exchange Act, as amended from time to time), of securities
of the Company representing greater

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      than 50 (fifty) percent of the combined voting power of the Company’s then
outstanding securities; or

  b.   When, subsequent to the effective date of this Agreement, the individuals
who, at the beginning of such period, constitute the Board (“Incumbent
Directors”) cease for any reason other than death to constitute at least a
majority thereof; provided, however, that a director who was not a director at
the beginning of this period will be deemed to have satisfied the definition of
“Incumbent Director” if such director was elected by, or with the approval of,
at least 60% (sixty percent) of the directors who then qualified as Incumbent
Directors; or     c.   Any sale, lease, exchange or other transfer (in one
transaction or a series of related transactions) of all or substantially all of
the assets of the Company or the approval by the shareholders of the Company of
any such transaction, whichever first occurs, or the adoption of any plan or
proposal for the liquidation or dissolution of the Company.

     For purposes of this Agreement, the “Change of Control Date’ shall mean the
first date on which an event constituting a Change of Control occurs.

     For purposes of this Agreement, the “Surviving Entity” shall mean the
Company or its successor, or the parent of the Company or its successor if the
Company or its successor becomes a subsidiary of another entity as a result of a
Change in Control.

     (ii) In the event a Change of Control occurs or is agreed to, the Company
or the Surviving Entity shall either (i) offer to Employee a position with the
Company or the Surviving Entity after the Change of Control, or (ii) advise
(“Termination Advice”) the Employee that there will not be a position for the
Employee after the Change of Control and that the Employee will be terminated by
a specified date. Where a position is offered to the Employee, the offer (the
“Offer”) shall specify (a) the entity (the “Employer”) that will employ Employee
after the Change of Control, (b) the title, authority, duties and
responsibilities that the Employee will have, (c) the base salary, (d) the terms
of any incentive compensation, bonus and stock option opportunities,
(e) employee benefit plans, programs, and policies then in effect which will
apply to Employee and (f) the terms of the non-competition agreement, which
shall terminate one year after the termination of employment with Company, the
Surviving Entity and their affiliates and related entities (the “Company
Affiliates”), and confidentiality agreement to be entered into by the Employee.
The Offer or Termination Advice will be provided to the Employee no later than
thirty (30) days after the Change of Control Date, and may be provided in
advance of said Date where feasible.

     Where an Offer is extended, the Employee shall have thirty (30) days to
consider and discuss the Offer. The Employee may accept or decline the Offer in
the Employee’s sole discretion. If Employee declines the Offer, the Employee
shall be entitled to receive the Severance Benefits effective upon the
Employee’s termination of employment with Company, the Surviving Entity and the
Company Affiliates (“Employment Termination”). If Employee accepts the Offer,
Employee shall be protected under this Agreement as provided in Section 2 for a
period of one year after the Change of Control.

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     If Employee receives Termination Advice, the Employee shall be entitled to
receive the Severance Benefits effective upon the Employment Termination.

     (iii) One Year Period After Offer. If Employee accepts an Offer, then,
during the one year period commencing on the date the Employee begins performing
services in accordance with the Offer, if (i) Employee terminates his or her
employment for Good Reason, or (ii) Company delivers a notice of termination of
this Agreement or fails to assign this Agreement to a successor employer, then
Employee shall be entitled to receive the Severance Benefits.

     “Good Reason” means (for purposes of this Agreement):

  a.   Action by the Employer that results in the material diminution of
Employee’s position, authority, duties or responsibilities as set forth in the
Offer absent Employee’s written consent;     b.   Employer’s assignment to
Employee of duties inconsistent with Employee’s position as set forth in the
Offer absent Employee’s written consent;     c.   Reduction in Employee’s salary
or material reduction in Employee’s bonus, long term compensation, retirement or
welfare benefits as set forth in the Offer absent Employee’s written consent; or
    d.   Except as set forth in the Offer or agreed to in writing by Employee,
Employer requiring that Employee maintain Employee’s home or principal place of
business outside the Minneapolis/St. Paul metropolitan area.

     4. Severance Benefits. In the event that the Employee is entitled to
severance pursuant to the provisions of Section 3.E, or the Employer terminates
this Agreement without Cause under Section 3.C., then Employee shall receive (in
lieu of any severance under any other plan, policy or other arrangement for the
benefit of Employee or for the Employer’s employees generally) the following
payments and benefits (the “Severance Benefits”):

  i.   Employee shall receive regular pay through date of Employment Termination
(the “Termination Date”), including pro-rated bonus (such bonus amount
determined as under Section 4.ii) earned for the partial year, if any;     ii.  
Employee shall receive payments equal to twelve (12) months of Employee’s then
current annualized salary, payable monthly, plus an amount equal to the average
of any bonus or incentive compensation paid or payable to the Employee for the
two most recent fiscal years, payable in equal monthly installments; and    
iii.   All unvested stock options held by the Employee shall immediately vest.

     Other than the Severance Benefits identified above, the Company shall have
no obligation past the Termination Date to provide Employee with severance
payments or employee benefits except for (a) benefits generally payable to
terminated employees under 401(k) plans, qualified

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benefits plans, and other employee benefit plans and (b) as may be mandated by
state or federal benefits continuation laws.

     5. Covenant Not to Compete. Employee hereby covenants and agrees that
during the term of this Agreement and until the later of (i) one year following
termination of this Agreement or any renewal thereof, or (ii) Employee’s receipt
of the last of any severance payments to Employee under Section 4, Employee
shall not be engaged within the United States, either directly or indirectly, in
any manner or capacity, whether as an advisor, principal, agent, partner,
officer, director, employee, or otherwise, in any business or activity, or own
beneficially or of record five per cent (5%) or more of the outstanding stock of
any class of equity securities in any corporation, in competition with the
business then being conducted by the Company, its subsidiaries or affiliates,
which business includes but may not be limited to the distribution of
medications for treatment of chronic illnesses, the management of chronic
disease states, and all research, analysis, and data services related to the
foregoing. The foregoing prohibition against competition includes, but is not
limited to, solicitation of any Company customer, patient, or referral source.
The restrictions herein shall not preclude Employee from practicing as a
dispensing pharmacist in a non-management capacity. Further, Employee will not
for one year following termination of his employment directly or indirectly
attempt to hire away any then-current employee of the Company, its subsidiaries
or affiliates, or take any action to persuade any such employee to leave
employment with the Company, its subsidiaries or affiliates.

     6. Confidentiality. Employee will in the course of his employment with the
Company have access to confidential or proprietary data or information belonging
to the Company, its subsidiaries or affiliates. Employee will not at any time
divulge or communicate to any person (other than to a person bound by
confidentiality obligations to the Company similar to those contained in this
Agreement) or use to the detriment of the Company, its subsidiaries or
affiliates, or for the benefit of any other person Confidential or Proprietary
Data or Information. The provisions of this Section 6 shall survive Employees’
employment hereunder regardless of the cause of termination of employment or
this Agreement and shall remain intact for a period of three (3) years following
termination for any reason. “Confidential or Proprietary Data or Information”
shall mean information Employee learns or develops during the course of
employment that derives economic value by being not generally known or
ascertainable by others and includes, without limitation, financial information,
customer lists, supplier lists, trade secrets, secret processes, computer data
and programs, pricing, marketing, and advertising data, strategic or operational
plans, methods of research and testing, management systems and matters related
to sales and marketing techniques. Employee acknowledges and agrees that any
Confidential or Proprietary Data or Information that Employee has already
acquired was in fact received in confidence and in Employee’s fiduciary capacity
with respect to the Company.

     All written materials, records and documents made by Employee or coming
into Employee’s possession during the term of employment concerning any product,
processes, information or services used, developed, investigated or considered
by the Company, its subsidiaries or affiliates, or otherwise concerning the
business or affairs of the Company, its subsidiaries or affiliates, shall be the
sole property of the Company and upon termination of Employee’s employment for
any reason, or upon request of the Board of Directors during Employee’s
employment, Employee shall promptly deliver the same to the Company. In

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addition, upon termination of Employee’s employment for any reason, or upon
request of the Board of Directors during Employee’s employment, Employee shall
deliver to the Company all other property of the Company in Employee’s
possession or under Employee’s control including, but not limited to, financial
statements, marketing and sales data, computer hardware and software, and
Company credit cards.

     7. Other Business Activities. Employee shall not serve as a director,
officer, employee, consultant, independent contractor or agent of another
company, whether for-profit, not-for-profit, charitable organization, foundation
or otherwise, during the term of this Agreement without the express prior
consent of the Company’s Board of Directors.

     8. Notices. All notices, requests, demands and other communications
provided for by this Agreement shall be in writing and shall be deemed to have
been given when mailed at any general or branch United States Post Office
enclosed in a certified postpaid envelope, return receipt requested, and
addressed to the address of the respective party stated below or to such changed
address as the party may have fixed by notice:

                    If to the Employee:
                    Anthony J. Zappa
                    7110 W. 83rd St.
                    Bloomington, MN 55438

                    If to the Company:
                    Chronimed Inc.
                    10900 Red Circle Drive
                    Minnetonka, MN 55343
                    Attn: Chief Executive Officer

Any notice of change of address shall only be effective, however, when received.

     9. Successors and Assigns. This Agreement shall inure to the benefit of,
and be binding upon, the Company, its successors and assigns, including, without
limitation, any corporation which may acquire all or substantially all of the
Company’s assets and business or into which the Company may be consolidated or
merged, and the Employee, his heirs, executors, administrators and legal
representatives. The Employee may not assign his rights or obligations under
this Agreement without the prior consent of the Company. The Company may assign
this Agreement to any entity acquiring substantially all the assets or business
of the Company or any subsidiary entity of the Company to which Employee is
assigned, by way of purchase, merger, or otherwise.

     10. Applicable Law. This Agreement shall be governed by the laws of the
State of Minnesota.

     11. Other Agreements. This Agreement supersedes all prior understandings
and agreements between the parties. It may not be amended orally, but only by a
writing signed by the parties hereto.

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     12. Non-waiver. No delay or failure by either party in exercising any right
under this Agreement, and no partial or single exercise of that right, shall
constitute a waiver of that or any other right.

     13. Headings. Headings in this Agreement are for convenience only and shall
not be used to interpret or construe its provisions.

     14. Counterparts. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original but all of which
together shall constitute one and the same instrument.

     15. Severability. If any provision of this Agreement is found to be
invalid, prohibited, or unenforceable, such provision shall be deemed modified
to the extent necessary to make it valid and enforceable or, if it cannot be
modified, then severed and the remainder of this Agreement shall remain in full
force and effect.

          CHRONIMED INC.   EMPLOYEE
 
       
By
  /S/ Henry F. Blissenbach   /S/ Anthony J. Zappa

       

  Chairman and CEO    

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