Exhibit 10.25.2

Date:        November 18, 2014

To:
Regeneron Pharmaceuticals, Inc.

777 Old Saw Mill River Road
Tarrytown, NY 10591-6707
    
Attention:
Dominick Agron

Vice President & Treasurer
777 Old Saw Mill River Road
Tarrytown, NY 10591-6707

Facsimile:
(914) 847-5892

        
From:
Credit Suisse Capital LLC

Eleven Madison Avenue
New York, NY 10010

With Credit Suisse Securities (USA) LLC as agent
Eleven Madison Avenue
New York, NY 10010

Re:
Second Amendment of the Warrant Transaction between Credit Suisse Capital LLC
and Regeneron Pharmaceuticals, Inc.

________________________________________________________________________

Dear Sir/Madam:

Credit Suisse Capital LLC (“CS”) and Regeneron Pharmaceuticals, Inc. (“Issuer”)
are parties to a warrant transaction pursuant to a November 13, 2013 assignment
by Credit Suisse International, an affiliate of Dealer, to CS of such warrant
transaction. The warrant transaction is evidenced by the Master Terms and
Conditions for Base Warrants Issued by Regeneron Pharmaceuticals, Inc. dated as
of October 18, 2011, supplemented by the written confirmation dated as of
October 18, 2011 (the “Confirmation”) and amended by the Amendment dated as of
May 14, 2014. Terms used herein but are not otherwise defined shall have
meanings assigned to them in the Warrant Confirmation.

Upon the effectiveness of this Amendment, all references in the Confirmation to
the “Number of Warrants” will be deemed to be to the Number of Warrants as
amended hereby and all references in the Confirmation to the “Transaction” will
be deemed to be to the Transaction as amended hereby.

1. Amendments. Effective upon payment of the Amendment Payment on the Payment
Date (as defined below), the Number of Warrants for each Component of the
Transaction shall be reduced by 1/80th of the Applicable Number of Warrants (as
defined below), with each such Number of Warrants rounded up to the nearest
whole number, except that the Number of Warrants for the Component with the
latest Expiration Date shall be reduced by the aggregate number resulting from
such rounding.

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2. Amendment Payment. In consideration of the amendment of the Transaction,
Issuer agrees to pay to CS on the Payment Date an amount in USD (the “Amendment
Payment”).

Applicable Number of Warrants:    328,820

Amendment Payment Amount:        USD 100,719,583.64

Payment Date:                November 21, 2014

3. Representations and Warranties.

(a)     Each party represents to the other party that:

(i)    It is duly organized and validly existing under the laws of the
jurisdiction of its organization or incorporation and, if relevant under such
laws, in good standing.

(ii)    It has the power to execute this Amendment and any other documentation
relating to this Amendment to which it is a party, to deliver this Amendment and
any other documentation relating to this Amendment that it is required by this
Amendment to deliver and to perform its obligations under this Amendment and has
taken all necessary action to authorize such execution, delivery and
performance.

(iii)    Such execution, delivery and performance do not violate or conflict
with any law applicable to it, any provision of its constitutional documents,
any order or judgment of any court or other agency of government applicable to
it or any of its assets or any contractual restriction binding on or affecting
it or any of its assets.

(iv)    All governmental and other consents that are required to have been
obtained by it with respect to this Amendment have been obtained and are in full
force and effect and all conditions of any such consents have been complied
with.

(v)    Its obligations under this Amendment constitute its legal, valid and
binding obligations, enforceable in accordance with their respective terms
(subject to applicable bankruptcy, reorganization, insolvency, moratorium or
similar laws affecting creditors' rights generally and subject, as to
enforceability, to equitable principles of general application (regardless of
whether enforcement is sought in a proceeding in equity or at law)).

(b)     Issuer represents and warrants to and for the benefit of CS as follows:

(i)    (A) On each of November 17th, 2014 and the date hereof, Issuer is not
aware of any material non-public information regarding Issuer or the Shares and
(B) its most recent Annual Report on Form 10-K, taken together with all reports
and other documents subsequently filed by Issuer with the Securities and
Exchange Commission pursuant to the Securities Exchange Act of 1934, as amended
(the “Exchange Act”), when considered as a whole (with the more recent such
reports and documents deemed to amend inconsistent statements contained in any
earlier such reports and documents), does not contain any untrue statement of a
material fact or omit to state any material

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fact required to be stated therein or necessary to make the statements therein,
in the light of the circumstances in which they were made, not misleading.

(ii)    On the date hereof and on the Payment Date, (A) the assets of Issuer at
their fair valuation exceed the liabilities of Issuer, including contingent
liabilities, (B) the capital of Issuer is adequate to conduct the business of
Issuer and (C) Issuer has the ability to pay its debts and obligations as such
debts mature and does not intend to, or does not believe that it will, incur
debt beyond its ability to pay as such debts mature.

(iii)    Issuer acknowledges its responsibilities under applicable
federal securities laws, including, without limitation, Rule 10b-5 under the
Exchange Act, in relation to the Transaction and its amendment.

4. No Additional Amendments or Waivers. Except as amended hereby, all the terms
of the Transaction and provisions in the Confirmation shall remain and continue
in full force and effect and are hereby confirmed in all respects.

5. Counterparts. This Amendment may be signed in any number of counterparts,
each of which shall be an original, with the same effect as if all of the
signatures thereto and hereto were upon the same instrument.

6. Governing Law. The provisions of this Amendment shall be governed by the New
York law (without reference to choice of law doctrine).

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Please confirm that the foregoing correctly sets forth the terms of our
agreement by executing this Amendment and returning it in the manner indicated
in the attached cover letter.

CREDIT SUISSE CAPITAL LLC

By: /s/ Bik Kwan Chung                
Name:    Bik Kwan Chung                                        
Title:    Authorized Signatory                            

By: /s/ Louis J. Impellizeri                
Name:    Louis J. Impellizeri                                        
Title:    Authorized Signatory                            

CREDIT SUISSE SECURITIES (USA) LLC, as agent for Credit Suisse Capital LLC

By: /s/ Bik Kwan Chung                
Name:    Bik Kwan Chung                                        
Title:    Vice President

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Agreed and Accepted By:

REGENERON PHARMACEUTICALS, INC.

By: /s/ Dominick Agron
Name: Dominick Agron
Title: Vice President & Treasurer

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