Ex. 10.3

ALEXION PHARMACEUTICALS, INC.
AMENDED AND RESTATED 2015 EMPLOYEE STOCK PURCHASE PLAN

Section 1.    Defined Terms

Exhibit A, which is incorporated by reference, defines the terms used in the
Plan and sets forth certain operational rules related to those terms.

Section 2.    Purpose of Plan

The Plan is intended to enable Eligible Employees of the Company and its
Designated Subsidiaries to use payroll deductions to purchase shares of Stock,
and thereby acquire an interest in the future of the Company. The Plan is
intended to qualify as an “employee stock purchase plan” under Section 423 and
to be exempt from the application and requirements of Section 409A of the Code,
and is to be construed accordingly.

Section 3.    Options to Purchase Stock

Subject to adjustment pursuant to Section 16 of this Plan, the maximum aggregate
number of shares of Stock available for purchase pursuant to the exercise of
Options granted under the Plan to Eligible Employees will be 1,000,000 shares.
The shares of Stock to be delivered upon exercise of Options under the Plan may
be either shares of authorized but unissued Stock, treasury Stock, or Stock
acquired in an open-market transaction, all as the Board may determine. If any
Option granted under the Plan expires or terminates for any reason without
having been exercised in full or ceases for any reason to be exercisable in
whole or in part, the unpurchased shares of Stock subject to such Option will
again be available for purchase pursuant to the exercise of Options under the
Plan. If, on an Exercise Date, the total number of shares of Stock that would
otherwise be subject to Options granted under the Plan exceeds the number of
shares then available under the Plan (after deduction of all shares for which
Options have been exercised or are then outstanding), the Administrator shall
make a pro rata allocation of the shares remaining available for the Option
grants in as uniform a manner as shall be practicable and as it shall determine
to be equitable. In such event, the Administrator shall give written notice to
each Participant of such reduction of the number of Options affected thereby and
shall similarly reduce the rate of payroll deductions, if necessary.

Section 4.    Eligibility

Subject to Section 13 and Section 18, and any exceptions and limitations set
forth in Section 6 or as permitted under Section 423, or as may be provided
elsewhere in the Plan or any sub-plan contemplated by Section 18, each Employee
who (a) has been continuously employed by the Company or a Designated Subsidiary
as of the first day of any Option Period, (b) customarily works twenty (20)
hours or more per week, (c) is employed by the Company or a Designated
Subsidiary, and (d) satisfies the requirements set forth in the Plan will be an
“Eligible Employee.” Notwithstanding the above, an Employee who is a citizen or
resident of a foreign jurisdiction (without regard to whether such Employee is
also a citizen of the United States or resident alien in the United States)

--------------------------------------------------------------------------------

shall not be an Eligible Employee with respect to the Plan if the grant of an
Option to such Employee is prohibited under the laws of the Employee’s foreign
jurisdiction or compliance with the laws of the foreign jurisdiction would cause
the Plan
or an Option to violate the requirements of Section 423. In no event, however,
may an Employee be granted an Option under the Plan if, immediately after the
Option is granted, the Employee would own (or pursuant to Section 424(d) of the
Code would be deemed to own) stock possessing five percent (5%) or more of the
total combined voting power or value of all classes of stock of the Company or
of any Parent or Subsidiary as may exist from time to time. The Administrator
may, for Option Periods that have not yet commenced, establish additional
eligibility requirements not inconsistent with Section 423.

Section 5.    Option Periods

The Plan will generally be implemented by a series of “Option Periods.” Unless
otherwise determined by the Administrator, the Option Periods will be the five
and one-half month periods commencing January 1 and ending June 15 and
commencing July 1 and ending December 15 of each year. Each June 15 and December
15 will be an “Exercise Date.” The Administrator may change the Exercise Date
and the commencement date, ending date and duration of the Option Periods to the
extent permitted by Section 423.

Section 6.    Option Grant

Subject to the limitations set forth in Section 4 and Section 10 and the Maximum
Share Limit, on the first day of an Option Period, each Participant
automatically will be granted an Option to purchase shares of Stock on the
Exercise Date; provided, however, that no Participant will be granted an Option
under the Plan that permits the Participant’s right to purchase shares of Stock
under the Plan and under all other employee stock purchase plans of the Company
and its Parent and Subsidiaries, if any, to accrue at a rate that exceeds
$25,000 in Fair Market Value (or such other maximum as may be prescribed from
time to time by the Code) for each calendar year during which any Option granted
to such Participant is outstanding at any time, as determined in accordance with
Section 423(b)(8) of the Code.

Section 7.    Method of Participation

To participate in an Option Period, an Eligible Employee must execute and
deliver to the Administrator a payroll deduction and participation authorization
form in accordance with the procedures prescribed by and in a form acceptable to
the Administrator and, in so doing, the Eligible Employee will thereby become a
Participant as of the first day of such Option Period. Such an Eligible Employee
will remain a Participant with respect to subsequent Option Periods until his or
her participation in the Plan is terminated as provided herein. Such payroll
deduction and participation authorization must be delivered no later than thirty
(30) calendar days prior to the first day of an Option Period, or such other
time as specified by the Administrator.

A Participant’s authorization will remain in effect for subsequent Option
Periods unless the Participant files a new authorization within thirty (30)
calendar days prior to

--------------------------------------------------------------------------------

the first day of an Option Period (or such other time as specified by the
Administrator) or as provided in the paragraph immediately below or the
Participant’s Option is cancelled pursuant to Section 13 or Section 14.

During an Option Period, a Participant’s payroll deduction authorization
applicable to such Option Period may be decreased only one time. To make such a
decrease, the Participant must submit a new payroll deduction and participation
authorization form authorizing the new rate of payroll deductions at least
thirty (30) calendar days (or such other time as specified by the Administrator)
prior to the Exercise Date. The foregoing does not limit a Participant’s right
to terminate his or her payroll deduction authorization by canceling or
suspending his or her Option in accordance with Section 13.

Except as otherwise determined by the Administrator, each payroll deduction
authorization will request payroll deductions in an amount expressed as a whole
percentage, between one percent (1%) and fifteen percent (15%) of the
Participant’s total base compensation per payroll period, determined as of the
first day of an Option Period, including base pay or base salary.

If the Administrator determines that another limit shall be imposed on maximum
payroll deductions hereunder or that eligible compensation shall be defined in a
different manner, determinations shall be made in a manner that satisfies the
requirements of Treasury Regulation Section 1.423-2(f)(2).

All payroll deductions made pursuant to this Section 7 will be credited to the
Participant’s Account. Amounts credited to a Participant’s Account will not be
required to be set aside in trust or otherwise segregated from the Company’s
general assets.

Section 8.    Method of Payment

A Participant must pay for shares of Stock purchased upon the exercise of an
Option with accumulated payroll deductions credited to the Participant’s
Account.

Section 9.    Purchase Price

The Purchase Price of shares of Stock issued pursuant to the exercise of an
Option on each Exercise Date will be eighty-five percent (85%) (or such greater
percentage specified by the Administrator to the extent permitted under Section
423) of one of the following, as selected by the Administrator prior to the
commencement of the relevant Option Period:

(a)    the Fair Market Value of a share of Stock on the date on which the Option
was granted pursuant to Section 6 (i.e., the first day of the Option Period);

(b)    the Fair Market Value of a share of Stock on the date on which the Option
is deemed exercised pursuant to Section 10 (i.e., the Exercise Date); or

--------------------------------------------------------------------------------

(c)
the lesser of (a) and (b).

Section 10.    Exercise of Options

Subject to the limitations set forth in Section 6 and this Section 10, with
respect to each Option Period, on the applicable Exercise Date, each Participant
will be deemed to have exercised his or her Option and total accumulated payroll
deductions in the Participant’s Account will be used to purchase full and
fractional shares of Stock at the applicable Purchase Price that can be
purchased with such Account balance at the applicable Purchase Price; provided,
however, that no more than 350 shares of Stock may be purchased by a Participant
on any Exercise Date, or such lesser number as the Administrator may prescribe
in accordance with Section 423 (the “Maximum Share Limit”). As soon as
practicable thereafter, shares of Stock so purchased will be placed, in
book-entry form, into a record keeping account in the name of the Participant.
Shares of Stock will be uncertificated; provided, however, that the
Administrator shall have the discretion to establish procedures regarding the
provision of stock certificates in the event such certificates are requested by
a Participant. Prior to the commencement of an Option Period, the Administrator
shall determine whether any payroll deductions accumulated in a Participant’s
Account that are not sufficient to purchase a full share will be retained in the
Participant’s Account for the subsequent Option Period, subject to earlier
withdrawal by the Participant as provided in Section 13, or returned to the
Participant or his or her legal representative, as applicable, without interest,
as soon as administratively practicable after the Exercise Date or earlier
withdrawal, as applicable.

Any amount of payroll deductions in a Participant’s Account that are not used
for the purchase of shares of Stock, whether because of the Participant’s
withdrawal from participation in an Option Period or for any other reason, will
be returned to the Participant or his or her legal representative, as
applicable, without interest, as soon as administratively practicable after such
withdrawal or other event, as applicable.

If the Participant’s accumulated payroll deductions on the Exercise Date would
otherwise enable the Participant to purchase shares of Stock in excess of the
Maximum Share Limit or the maximum Fair Market Value set forth in Section 6, the
excess of the amount of the accumulated payroll deductions over the aggregate
Purchase Price of the shares of Stock actually purchased will be returned to the
Participant, without interest, as soon as administratively practicable after
such Exercise Date.

Notwithstanding any provision of the Plan to the contrary, no Option may be
exercised after 27 months from its grant date.

Section 11.    Interest

No interest will be payable on any amount held in the Account of any
Participant.

Section 12.    Taxes

Payroll deductions will be made on an after-tax basis. The Administrator will
have the right, as a condition to the exercise of an Option, to make such
provision as it deems necessary to satisfy its obligations to withhold federal,
state, local income or other

--------------------------------------------------------------------------------

taxes incurred by reason of the purchase or disposition of shares of Stock under
the Plan. In the Administrator’s discretion and subject to applicable law, such
tax obligations may be paid in whole or in part by delivery of shares of Stock
to the Company, including shares of Stock purchased under the Plan, valued at
Fair Market Value, but not in excess of the minimum statutory amounts required
to be withheld.

Section 13.    Suspension, Cancellation and Withdrawal

A Participant who holds an Option under the Plan may suspend his or her payroll
deduction authorization by revoking such authorization by written notice
delivered to the Administrator. Upon such suspension, the accrued balance in the
Participant’s Account will remain and will be used to purchase shares of Stock
on the Exercise Date for the current Option Period.

A Participant who holds an Option under the Plan may cancel all (but not less
than all) of his or her Option and terminate his or her payroll deduction
authorization by revoking such
authorization by written notice delivered to the Administrator, which, to be
effective with respect to an upcoming Exercise Date, must be delivered not later
than thirty (30) business days prior to such Exercise Date (or such other time
as specified by the Administrator). Upon such termination and cancellation, the
balance in the Participant’s Account will be returned to the Participant,
without interest, as soon as administratively practicable thereafter.

A Participant who makes a hardship withdrawal from a 401(k) Plan will be deemed
to have terminated his or her payroll deduction authorization for subsequent
payroll dates relating to the then current Option Period as of the date of such
hardship withdrawal and amounts accumulated in the Participant’s Account as of
such date will be returned to the Participant, without interest, as soon as
administratively practicable thereafter. An Employee who has made a hardship
withdrawal from a 401(k) Plan will not be permitted to participate in Option
Periods commencing after the date of his or her hardship withdrawal until the
first Option Period that begins at least six (6) months after the date of his or
her hardship withdrawal.

Section 14.    Termination of Employment; Death of Participant

Upon the termination of a Participant’s employment with the Company (or a
Designated Subsidiary, as applicable) for any reason or the death of a
Participant during an Option Period prior to an Exercise Date or in the event
the Participant ceases to qualify as an Eligible Employee, the Participant will
cease to be a Participant, any Option held by him or her under the Plan will be
deemed canceled, the balance in the Participant’s Account will be returned to
the Participant (or his or her estate or designated beneficiary in the event of
the Participant’s death), without interest, as soon as administratively
practicable thereafter, and the Participant will have no further rights under
the Plan.

Section 15.    Equal Rights; Participant’s Rights Not Transferable

--------------------------------------------------------------------------------

All Participants granted Options under the Plan will have the same rights and
privileges consistent with the requirements set forth in Section 423 except for
Participants in certain sub- plans of non-U.S. Designated Subsidiaries, as
described in Section 18. Any Option granted under the Plan will be exercisable
during the Participant’s lifetime only by him or her and may not be sold,
pledged, assigned, or transferred in any manner. In the event any Participant
violates or attempts to violate the terms of this Section 15, as determined by
the Administrator in its sole discretion, any Options held by him or her may be
terminated by the Company and, upon the return to the Participant of the balance
of his or her Account, without interest, all of the Participant’s rights under
the Plan will terminate.

Section 16.    Change in Capitalization; Merger

In the event of any change in the outstanding Stock by reason of a stock
dividend, split- up, recapitalization, merger, consolidation, reorganization, or
other capital change, the aggregate number and type of shares of Stock available
under the Plan, the number and type of shares of Stock granted under any
outstanding Options, the maximum number and type of shares of Stock purchasable
under any outstanding Options, and the purchase price per share of Stock under
any outstanding Option will be appropriately adjusted; provided, that no such
adjustment will be made unless the Administrator is satisfied that it will not
constitute a modification of the rights
granted under the Plan or otherwise disqualify the Plan as an employee stock
purchase plan under the provisions of Section 423.

In the event of a sale of all or substantially all of the Stock or a sale of all
or substantially all of the assets of the Company, or a merger or similar
transaction in which the Company is not the surviving corporation or that
results in the acquisition of the Company by another person, the Administrator
may, in its discretion, (a) if the Company is merged with or acquired by another
corporation, provide that each outstanding Option will be assumed or exchanged
for a substitute Option granted by the acquiror or successor corporation or by a
parent or subsidiary of the acquiror or successor corporation, (b) cancel each
outstanding Option and return the balances in Participants’ Accounts to the
Participants, and/or (c) pursuant to Section 18, terminate the Option Period on
or before the date of the proposed sale, merger or similar transaction.

Section 17.    Administration of Plan

The Plan will be administered by the Administrator, which will have the right to
determine any questions which may arise regarding the interpretation and
application of the provisions of the Plan and to make, administer, and interpret
such rules and regulations as it deems necessary or advisable. All
determinations and decisions by the Administrator regarding the interpretation
or application of the Plan will be final and binding on all Participants.

The Administrator may specify the manner in which Employees are to provide
notices and payroll deduction authorizations. Notwithstanding any requirement of
“written notice” herein, the Administrator may permit Employees to provide
notices and payroll deduction authorizations electronically.

--------------------------------------------------------------------------------

Section 18.    Sub-Plans; Amendment and Termination of Plan

The Board reserves the right at any time or times to amend the Plan to any
extent and in any manner it may deem advisable, by action of the Board;
provided, that any amendment that would be treated as the adoption of a new plan
for purposes of Section 423 will have no force or effect unless approved by the
shareholders of the Company within 12 months before or after its adoption.

The Plan may be suspended or terminated at any time by the Company, by action of
the Board. In connection therewith, the Board may provide, in its sole
discretion, either that outstanding Options will be exercisable either at the
Exercise Date for the applicable Option Period or on such earlier date as the
Board may specify (in which case such earlier date will be treated as the
Exercise Date for the applicable Option Period), or that the balance of each
Participant’s Account will be returned to the Participant, without interest.

Notwithstanding the foregoing or any provision of the Plan to the contrary, the
Administrator may, in its sole discretion, amend the terms of the Plan, or an
Option, in order to reflect the impact of local law outside of the United States
as applied to one or more Eligible Employees of a Non-U.S. Designated Subsidiary
and may, where appropriate, establish one or more sub-plans to reflect such
amended provisions; provided, however, in no event shall any sub-plan (a) be
considered part of the Plan for purposes of Section 423 of the Code or (b) cause
the Plan (other than the sub-plan) to fail to satisfy the requirements of
Section 423 of the Code. In the event of any inconsistency between a sub-plan
and the Plan document, the terms of the sub-plan shall govern with respect to
any Eligible Employees of a Non-U.S. Designated Subsidiary. For the avoidance of
doubt, shares of Stock purchased under a sub-plan shall reduce the maximum
aggregate number of shares available for purchase pursuant to Section 3.

Section 19.    Recycling of Shares.

In the event of the expiration, withdrawal, termination or other cancellation of
an Option under the Plan, the number of Shares of Stock that were subject to the
Option but not delivered shall again be available for issuance under the Plan.

Section 20.    Approvals

Notwithstanding anything herein to the contrary, the obligation of the Company
to issue and deliver shares of Stock under the Plan will be subject to the
approval required of any governmental authority in connection with the
authorization, issuance, sale or transfer of said shares of Stock and to any
requirements of any national securities exchange applicable thereto.

Section 21.    Participants’ Rights as Shareholders and Employees

A Participant will have no rights or privileges as a shareholder of the Company
and will not receive any dividends in respect of any shares of Stock covered by
an Option granted hereunder until such Option has been exercised, full payment
has been

--------------------------------------------------------------------------------

made for such shares of Stock, and the shares of Stock have been issued to the
Participant.

Nothing contained in the provisions of the Plan will be construed as giving to
any Employee the right to be retained in the employ of the Company or any
Designated Subsidiary or as interfering with the right of the Company or any
Designated Subsidiary to discharge, promote, demote or otherwise re-assign any
Employee from one position to another within the Company any Designated
Subsidiary or non-U.S. Designated Subsidiary at any time.

Section 22.    Governing Law

The Plan will be governed by and interpreted consistently with the laws of the
State of Delaware, except as may be necessary to comply with applicable
requirements of federal law. For purposes of litigating any dispute that arises
under the Plan, such litigation shall be conducted only in the courts of New
Haven County, Connecticut, or the federal courts for the United States for the
District of Connecticut, and no other courts.

Section 23.    Notices.

Any notice or document required to be filed with the Administrator under or with
respect to the Plan will be properly filed if delivered or mailed by registered
mail, postage prepaid (or in such other form acceptable to the Administrator),
to the Administrator at the Administrator’s principal executive offices. The
Administrator may, by advance written notice to affected persons, revise any
notice procedure applicable to it from time to time. Any notice required under
the Plan may be waived by the person entitled to notice.
Section 24.    Effective Date and Term

Subject to the approval by the Company’s shareholders at the Company’s 2015
annual meeting, the Plan will become effective on May 6, 2015 (the “Effective
Date”) and no rights will be granted hereunder after the earliest to occur of
(a) the Plan’s termination by the
Company, (b) the issuance of all shares of Stock available for issuance under
the Plan or (c) May 6, 2025. This Plan, as amended and restated, shall be
effective for Option Periods commencing on or after September 15, 2018.

EXHIBIT A
Definition of Terms

The following terms, when used in the Plan, will have the meanings and be
subject to the provisions set forth below:

“401(k) Plan”: A savings plan qualifying under Section 401(k) of the Code that
is sponsored by the Company or one of its Subsidiaries for the benefit of its
employees.

--------------------------------------------------------------------------------

“Account”: A payroll deduction account maintained in the Participant’s name on
the books of the Company or a Designated Subsidiary.

“Administrator”: The Leadership and Compensation Committee of the Board and its
delegates, except that the Compensation Committee may delegate its authority
under the Plan to a sub-committee comprised of one or more of its members, to
members of the Board, or to officers or employees of the Company to the extent
permitted by applicable law. In each case references herein to the Administrator
refer, as applicable, to such persons or groups so delegated to the extent of
such delegation.

“Board”: The Board of Directors of the Company.

“Code”: The U.S. Internal Revenue Code of 1986 as from time to time amended and
in effect, or any successor statute as from time to time in effect.

“Company”: Alexion Pharmaceuticals, Inc.

“Designated Subsidiary”: A Subsidiary of the Company that has been designated by
the Board or the Compensation Committee of the Board from time to time as
eligible to participate in the Plan. Exhibit B sets forth the Designated
Subsidiaries as of the Effective Date.

“Effective Date”: The date set forth in Section 24 of the Plan.

“Eligible Employee”: Any Employee who meets the eligibility requirements set
forth in Section 4 of the Plan or any other service provider who is eligible to
participate under the specific rules of a sub-plan, as described in Section 18,
regardless of whether he or she meets the eligibility requirements under Section
4 of this Plan.

“Employee”: Any person who is employed by the Company or a Designated
Subsidiary. For the avoidance of doubt independent consultants and independent
contractors are not “Employees” for purposes of the Plan. Notwithstanding any
other provision of the Plan, individuals who are not treated as common law
employees by the Company or a Designated Subsidiary on their payroll records are
excluded from Plan participation even if a court or administrative agency
determines that such individuals are common law employees and not independent
contractors. No employee of the Company or any Designated Subsidiary shall be
eligible to participate in the Plan if the Administrator determines that such
participation could be in violation of any local law and that it is permissible
to exclude such employees from participation in the Plan under Section 423.
“Exercise Date”: The date set forth in Section 5 of the Plan or otherwise
designated by the Administrator with respect to a particular Option Period on
which a Participant will be deemed to have exercised the Option granted to him
or her for such Option Period.

“Fair Market Value”:

(a)    If the Stock is readily traded on an established U.S. national exchange
or trading system (including the Nasdaq Global Market), the closing price of the
Stock as

--------------------------------------------------------------------------------

reported by the principal exchange on which such Stock is traded; provided,
however, that if such day is not a trading day in the U.S. Fair Market Value
will mean the reported closing price of the Stock for the immediately preceding
day that is a trading day.

(b)    If the Stock is not traded on an established U.S. national exchange or
trading system, the average of the bid and ask prices for such Stock where the
bid and ask prices are quoted.

(c)    If the Stock cannot be valued pursuant to clauses (a) or (b), the value
as determined in good faith by the Board in its sole discretion.

“Maximum Share Limit”: The meaning set forth in Section 10 of the Plan.

“Non-U.S. Designated Subsidiary”: A Subsidiary of the Company incorporated
outside of the United States that has been designated by the Board or the
Compensation Committee of the Board from time to time as eligible to participate
in the Plan. Exhibit C sets forth the Non-
U.S.
Designated Subsidiaries as of the Effective Date.

“Option”: An option granted pursuant to the Plan entitling the holder to acquire
shares of Stock upon payment of the Purchase Price per share of Stock.

 
“Option Period”: An offering period established in accordance with Section 5 of
the Plan
 
    “Parent”: A “parent corporation” as defined in Section 424(e) of the Code.

“Participant”: An Eligible Employee who elects to enroll in the Plan.

“Plan”: The Alexion Pharmaceuticals, Inc. 2015 Employee Stock Purchase Plan, as
from time to time amended and in effect.

“Purchase Price”: The price per share of Stock with respect to an Option Period
determined in accordance with Section 9 of the Plan.

“Section 423”: Section 423 of the Code and the regulations thereunder.

“Stock”: Common stock of the Company, par value $0.0001 per share.

“Subsidiary”: A “subsidiary corporation” as defined in Section 424(f) of the
Code.