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AMENDMENT TO EMPLOYMENT AGREEMENT

W. SCOTT HARKONEN ("EXECUTIVE"):

    Effective March 6, 2001, INTERMUNE PHARMACEUTICALS, INC. (the "Company") has
amended, as follows, that certain Employment Agreement between Executive and the
Company, which became effective as of October 15, 1998, as amended on June 8,
2000 (the "Agreement"):

1.Section 2.1—First Sentence: In lieu of "Two Hundred Seventy-Five Thousand
Dollars ($275,000.00)," the "annual base salary" shall be "Three Hundred
Thousand Dollars ($300,000), effective as of January 1, 2001. Any upward
adjustments to Executive's annual base salary may be effected by the approval of
the Company's Compensation Committee, with ratification by the Company's Board
of Directors, without necessity of amending this Agreement."

2.Section 2.1—Add the following sentence to the end of the section:

"Executive shall be paid a bonus of his Base Compensation, based upon
achievement of the Company's prior calendar year's corporate milestones."

3.Section 4—Delete the last sentence that reads:

"Notwithstanding the foregoing, the Company agrees that Executive may devote an
average of 20% of each work week to furnish consulting services to Connetics
Corporation; provided, that Executive's Base Compensation shall be reduced by
20% during such period as he performs such consulting services."

4.Section 8.3—In the first sentence, in lieu of the "Chief Executive Officer,"
the signatories shall be "Executive" and "Senior Vice President of Legal
Affairs."

5.Section 8.10—Add the following Section 8.10:

"This Agreement, as amended on March 6, 2001, and that certain Common Stock
Purchase Agreement, dated as of April 27, as amended February 23, 2000 (the
"Stock Purchase Agreement"), constitute the entire agreement between the parties
with respect to the subject matter hereof and supersede and merge all prior
agreements or understandings, whether written or oral. With respect to
interpretation and construction of provisions that may be inconsistent between
this Agreement and the Stock Purchase Agreement, the provisions of the Stock
Purchase Agreement shall control."

6.Except as specifically amended and modified herein, the Agreement shall
continue in force and effect pursuant to its terms.

Dated the 6th day of March 2001.

 
   
   
    INTERMUNE PHARMACEUTICALS, INC.
 
 
 
 
      By:   /s/ STEPHEN N. ROSENFIELD   

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STEPHEN N. ROSENFIELD
Senior Vice President of Legal Affairs

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ACKNOWLEDGEMENT

    The undersigned acknowledges receipt of the foregoing amendment and
understands that the rights and liabilities with respect to the Employment
Agreement described therein are set forth in the Employment Agreement.

Dated the 6th day of March 2001.

 
   
   
        /s/ W. SCOTT HARKONEN   

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W. SCOTT HARKONEN

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AMENDMENT TO EMPLOYMENT AGREEMENT
ACKNOWLEDGEMENT