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AMENDMENT TO EMPLOYMENT AGREEMENT

THIS AMENDMENT made effective the 18th day of August, 2009

BETWEEN:

Upstream Biosciences Inc., a company incorporated under the laws of the Province
of British Columbia, having its head office at 806-699 Cardero Street,
Vancouver, British Columbia V6G 3H7;

(the "Company")

AND:

Dexster Smith,

(the "Employee")

WHEREAS the Company and the Employee have agreed to amend the terms of the
Employment Agreement, dated March 1st, 2006 (the “Employment Agreement”), to
correct a mistake in the severance provisions at paragraph 4.4 of the said
agreement which provided for the payment of severance in the event that the
Employee was terminated by the Company for cause or in the event that the
Employee terminated the Employment Agreement by his resignation, and on the
terms and conditions contained herein;

IN CONSIDERATION of the mutual agreements in this Amendment and subject to the
terms and conditions specified in this Amendment, the parties agree as follows:

1. All capitalized terms not specifically defined herein have the meanings
ascribed to them in the Employment Agreement.

2. Article 4 of the Employment is hereby deleted and replaced in its entirety by
the following:

4. Termination

4.1 Employee's Right to Terminate for any Reason. The Employee may terminate
this Agreement and his or her employment for any reason:

  (a)

at any time upon providing 14 days advance notice in writing to the Company; or

        (b)

upon a material breach or default of any term of this Agreement by the Company,
but only if the Employee has first given written notice of such breach or
default to the Company and the Company has failed to rectify it within a period
of 30 days following receipt of such notice.

The Company shall be obliged to pay the Salary, and any Bonuses earned and
accrued but not paid, due up to the date of termination, with such payment to be
made within 30 days of the date of termination. Bonuses partially earned but not
yet payable as of the date of termination shall be payable.

4.2 Company's Right to Terminate for Cause. The Company may terminate this
Agreement and the Employee's employment for Cause at any time on written notice
to the Employee.

The date of termination will be the date specified in the written notice and may
be, in the sole discretion of the Company, the same day the notice is given to
the Employee, or such later date as the Company may decide. The Company shall be
obliged to pay the Salary, and any

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