Exhibit 10.3

Confidential

LOGO [g98950curagen-logo.jpg]

Interoffice Memorandum

 

To:    Personnel File From:    Timothy M. Shannon, EVP and Chief Medical Officer
Date:    January 24, 2007 Re:    Amendment to Employment Agreement dated
September 1, 2006

 

--------------------------------------------------------------------------------

I, Timothy M. Shannon, (“the Executive”) signed an Employment Agreement (“the
Agreement”) with my employer, CuraGen Corporation (“the Company”), on or about
September 1, 2006, providing that the Executive’s initial base salary shall be
subject to increases by the Board of Directors, which shall review the salary
periodically. Therefore, pursuant to the minutes of the January 24, 2007,
Meeting of the Compensation Committee of the Board of Directors, the Executive’s
2007 base salary will be adjusted to $344,500 per year, payable in bi-weekly
installments.

Unless explicitly changed in the Addendum dated January 24, 2007, all other
terms of the Agreement shall remain in full force and effect.

 

/s/ Timothy M. Shannon, MD

  Timothy M. Shannon, MD  

/s/ Frank M. Armstrong, MD

  Frank M. Armstrong, MD