EXHIBIT 10.1

September 23, 2005

BY PERSONAL DELIVERY

Paul J. Hastings
c/o 887 Great Northern Way
Vancouver, British Columbia
V5T 4T5

Dear Paul:

As discussed, we have mutually agreed that your employment with QLT Inc. (“QLT”)
will terminate effective September 23, 2005. All amounts payable by QLT and all
agreements of QLT set out herein are conditional upon you signing and returning
to QLT the attached release immediately and your continued compliance with your
ongoing obligations under the Definitive Executive Employment Agreement (the
“Agreement”) between you and QLT dated for reference December 18, 2001.

We have agreed that your entitlements to severance will be in accordance with
Section 5.3 of the Agreement, except as amended in this letter.

In lieu of notice, and subject to Section 5.5 of the Agreement, QLT will
continue to pay to you your base salary and an amount equal to your entitlement
under the Cash Incentive Compensation Plan for a period of 24 months until
September 23, 2007. The Cash Incentive Compensation Plan payments will be
prorated for partial years over this period and will be calculated at your
existing target level of 75% of your base salary. All payments will be made on a
twice-monthly basis and will be subject to statutory withholdings.

All benefits, except short and long term disability (both of which cease
effective immediately), will continue to the earlier of the date on which you
cease to be a resident of Canada and September 23, 2006. QLT will endevour to
extend those benefits (other than short and long term disability) until
September 23, 2007 provided QLT’s benefits provider determines you to be
eligible for such time. In the event you cease to be a resident of Canada prior
to September 23, 2007 or are not eligible for benefits after September 23, 2006,
then, from that date forward to September 23, 2007, QLT will pay you an amount
in lieu of benefits equal to 10% of your base salary, paid in equal
twice-monthly instalments and together with the payments noted above. These
payments are also subject to statutory withholdings and Section 5.5 of the
Agreement. Please note that certain of your benefits may be convertible to
individual plans. If you wish to convert any of your benefits to individual
plans, you should contact the Senior Vice President, Human Resources and
Organizational Development immediately.

By September 28, 2005, QLT will pay to you an amount to compensate you for your
remaining base salary owing to September 23, 2005, reimbursement of expenses,
vacation pay accrued to date (which we have agreed is 2 weeks), payment in lieu
of contribution to RRSP for 2005, 2006

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and 2007 and a prorated payment under the Cash Incentive Compensation Plan for
the period worked from January 1, 2005 to September 23, 2005 (calculated at your
existing target level of 75% of your base salary).

In addition, QLT will provide for payment of outplacement counselling in
accordance with the terms of Section 5.3 of the Agreement.

Under the terms of your Stock Option Agreements, 50% of your unvested stock
options as of September 23, 2005 will automatically vest on that date. In
addition, we agree to extend the period during which you may exercise your
vested stock options to September 23, 2006. Except as modified by this paragraph
with respect to the exercise period of the stock options, the terms of the Stock
Option Agreements and QLT’s Employee Incentive Stock Option Plan will govern the
vesting and exercise of any stock options which you may hold. We confirm that we
have previously advised you to seek independent tax advice with respect to the
personal tax consequences of the extension of the exercise period on the stock
options and with respect to the holding and exercising of those stock options.

In addition, QLT will continue to pay, during the 24 month period to September
23, 2007, your tax advisory fees in the same manner and to the same extent as
paid during your employment with QLT. To the extent your relocation costs are
not paid by a future employer, QLT will extend the Relocation Assistance
agreement set out in Schedule B of the Agreement, as amended, to September 23,
2007 which, for greater certainty includes relocation assistance regarding two
vehicles and one residence provided that the total amount to be reimbursed or
paid to you by QLT in connection with such relocation will not exceed $150,000.
We have also agreed that, in the event of a Change in Control of QLT as defined
in the Change of Control Agreement dated February 18, 2003, all amounts set out
in the 3rd and 4th paragraphs of this letter will become payable immediately and
in a lump sum (subject to all statutory withholdings).

We remind you that pursuant to Section 6A.1 of the Agreement, this agreement
constitutes your resignation from the Board of QLT and its subsidiaries and
affiliates. Nevertheless, a notice of resignation is attached and it is a
condition of our agreement that you sign that notice immediately. We also remind
you that your duties of confidentiality and the post-employment restrictions set
out in Sections 7 and 8 of the Agreement survive the termination of your
employment.

We confirm that your home relocation loan is forgiven and that QLT will promptly
file the appropriate mortgage discharge documents.

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Paul, we wish to thank you for the contribution that you have made to QLT during
your tenure with the company, and wish you the best of luck in your future
endeavours.

Yours truly,

QLT Inc.

Per:

      /s/ William J. Newell   /s/ Cameron Nelson

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William J. Newell   Cameron Nelson Senior Vice President & Chief Business
Officer   Vice President, Finance & Chief Financial Officer

Accepted and Agreed to this 23rd day of September, 2005

/s/ Paul J. Hastings                                    
Paul J. Hastings

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