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EXHIBIT 10.27

EMPLOYMENT AGREEMENT

     This Employment Agreement (“Agreement”) by and between Donald P. Francis,
M.D., D.Sc. (hereinafter “Francis”) and VaxGen, Inc. (hereinafter “VaxGen”) is
effective October 2, 2001. In consideration of the mutual promises made herein,
VaxGen and Francis agree as follows:

1. EMPLOYMENT. VaxGen hereby employs Francis, and Francis hereby accepts
employment with VaxGen upon all of the terms and conditions described in this
Agreement. Except with respect to any stock options previously granted to
Francis, this Agreement supercedes, replaces and restates any and all prior
agreements between the parties hereto relating to the terms of Francis’s
employment with VaxGen, including any prior agreements concerning
confidentiality, non-disclosure and inventions.

2. WORK RESPONSIBILITIES. Subject to the terms of this Agreement, Francis is
hereby employed in the position of President, and shall perform the functions
and responsibilities of that position. Francis shall devote the whole of
Francis’s professional time, attention and energies to the performance of his
work responsibilities. VaxGen may assign additional or different duties.
Francis’s position, job description, duties and responsibilities may be modified
from time to time in the sole discretion of VaxGen.

3. COMPENSATION. As consideration for the services and covenants described in
this Agreement, VaxGen agrees to compensate Francis during the term of this
Agreement in the following manner:

A. Salary/Wages. VaxGen agrees to pay Francis a base salary of $325,000 per
year. Francis’s salary, less required and authorized deductions, shall be paid
in equal, periodic installments no less frequently than semi-monthly in
accordance with VaxGen’s then current payroll practices.

B. Performance Bonus. Francis is eligible to receive an annual bonus of up to
thirty percent (30%) of his annual base salary in cash, VaxGen securities or a
combination thereof as determined in the sole discretion of VaxGen’s Board of
Directors. In addition, Francis will be eligible to receive an annual award of
stock options, which will be issued, if at all, in accordance with the terms and
conditions in effect under VaxGen’s Stock Option Plan at the time of the award,
in an amount to be determined in the sole discretion of the Board of Directors.
Such bonuses and options shall be awarded, if at all, at the sole discretion of
the Board of Directors. Francis’s salary, bonus and options will be considered
annually for potential adjustment by the Compensation Committee of the Board of
Directors.

C. Benefits. Francis shall be entitled to employment benefits in accordance with
policies established by or at the direction of VaxGen’s Board of Directors with
respect to senior officers of VaxGen, including holidays, leaves of absence,
health insurance, dental insurance, vacation and other benefits, if any, in
accordance with any eligibility requirements, policies, procedures, or benefit
plans adopted by VaxGen from time to time during the existence of this
Agreement. Francis’s rights, or those of Francis’s dependents under any such
benefits policies or plans, shall be governed solely by the terms of such
policies or plans. VaxGen’s employment benefits, and policies related thereto,
are subject to termination, modification or limitation at VaxGen’s sole
discretion.

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D. Total Compensation. Francis agrees that the compensation stated above
constitutes the full and exclusive monetary consideration and compensation for
all services rendered under this Agreement and for all promises and obligations
under this Agreement.

E. Business Expenses. VaxGen shall pay Francis’s reasonable business expenses,
including expenses incurred for travel on VaxGen business, in accordance with
the policies and procedures of VaxGen, as may be adopted or amended from time to
time at VaxGen’s sole discretion. If Francis incurs business expenses under this
Agreement, he shall submit monthly to VaxGen a request for reimbursement
together with supporting documentation satisfactory to VaxGen.

4. VAXGEN POLICIES. Francis agrees to abide by VaxGen’s policies, practices and
procedures, written and unwritten, as they may from time to time be adopted or
modified by VaxGen in its sole discretion. VaxGen’s written policies, practices
and procedures, including the Employee Handbook, shall be binding on Francis
unless superseded by, or in conflict with, this Agreement. Copies of written
policies and procedures are available to Francis in the offices of VaxGen, and
Francis shall be responsible at all times to review, and make himself familiar
with, these policies and procedures.

5. WARRANTIES. Francis hereby represents and warrants that he has taken no
confidential, proprietary or trade secret information from Francis’s prior
employer or employers, and will not knowingly disclose such information to
VaxGen, or improperly use any such information on behalf of VaxGen. Francis
acknowledges that VaxGen has specifically requested that, if Francis has any
such confidential, proprietary or trade secret knowledge or information, Francis
not use such information while employed by VaxGen for the benefit of VaxGen.
Francis further warrants that by entering into this Agreement with VaxGen he is
not violating any of the terms, agreements or covenants of any previous
employment or association.

6. PRIOR INVENTIONS. Francis acknowledges that, except for the inventions
disclosed on Appendix A, Francis does not have any right or claim to any
invention, idea, process, formula, discovery, copyright, patent or other such
item or matter. No rights are hereby conveyed by Francis to VaxGen with respect
to inventions, if any, made by Francis prior to employment by VaxGen, which
inventions are listed in Schedule A, attached hereto.

7. SUBSEQUENT INVENTION DISCLOSURE. Francis hereby agrees to promptly disclose
to VaxGen any and all inventions which he develops during the term of his
employment. Francis will also disclose to the Board of Directors of VaxGen all
inventions made, conceived, reduced to practice, or developed by Francis within
six months of the termination of his employment with VaxGen that resulted from
his prior work with VaxGen. Such disclosures shall be received by VaxGen in
confidence and do not extend the assignment of inventions disclosed beyond that
required by law.

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8. ASSIGNMENT OF INVENTIONS. Francis hereby assigns and agrees to assign to
VaxGen or its designee, Francis’s entire right, title and interest in and to all
inventions, works of authorship, developments, concepts, discoveries, ideas,
trademarks and trade secrets, whether or not patentable or registrable under
copyright or other intellectual property laws (“Inventions”) which Francis may
solely or jointly develop, conceive or reduce to practice, during the period of
employment, except as provided in paragraph 10 below. Francis agrees that all
such Inventions are the sole property of VaxGen. Francis further agrees that all
such Inventions, including works of authorship, are “works for hire” for
purposes of VaxGen’s rights under copyright laws. Francis agrees to keep and
maintain adequate and current written records of all Inventions made by him
(solely or jointly with others) during the term of his employment with VaxGen.
The records will be in the form of notes, sketches, drawings, and any other
format that may be specified by VaxGen. The records will be available to and
remain the sole property of VaxGen at all times. Francis understands and agrees
that the decision whether or not to commercialize or market any Invention
developed by him solely or jointly with others is within VaxGen’s sole
discretion and for VaxGen’s sole benefit and that no royalty will be due to him
as a result of VaxGen’s efforts to commercialize or market any such Invention.
Francis further agrees to perform, during and after employment with VaxGen, all
acts deemed necessary or desirable by VaxGen to permit and assist VaxGen, at
VaxGen’s expense, in obtaining and enforcing the full benefits, enjoyment,
rights and title, throughout the world, of and to the Inventions hereby assigned
by Francis to VaxGen as set forth above.

9. PATENT AND COPYRIGHT REGISTRATIONS. Francis agrees to assist VaxGen, or its
designee, at VaxGen’s expense, in every proper way to secure VaxGen’s rights in
the Inventions and any copyrights, patents, trademarks, and trade secret rights
or other intellectual property rights in connection with any such Inventions in
any and all countries, including the disclosure to VaxGen of all pertinent
information and data with respect thereto, the execution of all applications,
specifications, oaths, assignments and all other instruments or papers which
VaxGen shall deem necessary in order to apply for and obtain such rights and in
order to assign and convey to VaxGen, its successors, assigns, and nominees the
sole and exclusive rights, title and interest in and to such Inventions, and any
copyrights, patents, trademark and other intellectual property rights relating
thereto. Francis further agrees that his obligation to execute or cause to be
executed, when it is in his power to do so, any such instrument or papers shall
continue after the termination of this Agreement. If VaxGen is unable, because
of Francis’s mental or physical incapacity or for any other reason, to secure
his signature to apply for or to pursue any application for any United States or
foreign patents or copyright registrations covering Inventions or original works
of authorship assigned to VaxGen as above, then Francis hereby irrevocably
designates and appoints VaxGen and its duly authorized officers and agents as
his agent and attorney in fact to act for and in his behalf and stead to execute
and file any such applications and to do all other lawfully permitted acts to
further the prosecution and issuance of letters patent or copyright
registrations thereon with the same legal force and effect as if executed by
Francis.

10. INVENTIONS NOT ASSIGNED. The parties agree that the assignment of inventions
under this Agreement does not apply to an invention which qualifies fully for
protection under Section 2870 of the California Labor Code, which states that
“Any provision in an employment agreement which provides that an employee shall
assign, or offer to assign, any of his or her rights in an invention to his or
her employer shall not apply to an invention that the employee developed
entirely on his or her own time without using the employer’s equipment,
supplies, facilities or trade secret information except for those inventions
that either: (1) relate at the time of conception or reduction to practice of
the invention to the employer’s business, or actual or demonstrably anticipated
research or development of the employer; or (2) result from any work performed
by the employee for the employer.”

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11. CONFIDENTIAL, PROPRIETARY AND TRADE SECRET INFORMATION. During the course of
his employment, Francis will come into possession of or acquire knowledge of
confidential, proprietary and trade secret information of VaxGen. Francis hereby
covenants and agrees that he will not, either during his employment or at any
time thereafter, disclose any such confidential, proprietary or trade secret
information to any person, firm, corporation, association, partnership or other
entity (other than those in VaxGen’s organization qualified and authorized to
receive such information) for any purpose or reason whatsoever. Such
confidential and proprietary information shall be deemed to include, but not be
limited to, manuals, discs, tapes, and summaries or originals of any papers,
documents, plans, specifications, client lists, contracts, licenses or licensing
agreements, data bases, or portions thereof, related to the research and
development, products or operations of VaxGen, provided that such information is
confidential, proprietary or falls within the definition of a “trade secret”
under the Uniform Trade Secrets Act. Francis specifically agrees that he will
not make use of any such confidential or proprietary information for his own
purpose, or for the benefit of any person, firm, corporation or other entity
except VaxGen. Francis will abide by VaxGen’s policies and procedures, as
established from time to time for the protection of its trade secrets and
confidential information.

12. RETURN OF PROPERTY. All confidential, proprietary and trade secret
information, and all other documents, records, apparatus, equipment and other
physical property which is furnished to or obtained by Francis in the course of
employment with VaxGen, shall be and remain the sole property of VaxGen. Francis
agrees that upon request by VaxGen or the termination of Francis’s employment
(whichever occurs first), Francis shall return all such property, and agrees not
to make or retain copies, reproductions or summaries of any such property
without the express written consent of VaxGen.

13. NON-SOLICITATION, ANTI-RAIDING. For a period of one (1) year immediately
following the termination of his employment, Francis agrees that he will not,
either directly or indirectly, (a) attempt to recruit, solicit or take away any
of the employees of VaxGen who worked for VaxGen at any time during the term of
this Agreement; make known to any person, firm or corporation the names or
addresses of, or any information pertaining to, any current or former employees
of VaxGen; (b) use any confidential or proprietary information to attempt to
call on, solicit or take away any clients of VaxGen or any other persons,
entities, or corporations with which VaxGen has had or contemplated any business
transaction or relationship during Francis’s employment with VaxGen, including,
but not limited to, investments, licenses, joint ventures, and agreements for
development..

14. EQUITABLE RELIEF. Francis and VaxGen each agree that in the event of a
breach or threatened breach of paragraphs 7 through 13 of this Agreement each
party will not have an adequate remedy at law. Thus, in the event of such a
breach or threatened breach by one party, the other party will be entitled to
such equitable and injunctive relief in a court of law as may be available to
prevent and restrain a breach of the provisions of paragraphs 7 through 13. Said
availability to obtain injunctive relief will not prevent either party from
pursuing any other equitable or legal relief, including the recovery of damages
from such breach or threatened breach.

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15. AT-WILL EMPLOYMENT. Francis understands and agrees that employment at VaxGen
is at-will. This means that, for any reason or no reason, Francis’s employment
may be terminated, with or without cause, at any time by either Francis or by
VaxGen, subject to the severance and notice provisions contained in Section 16
below. Nothing in this or any other document or statement shall limit the right
of VaxGen to terminate Francis’s employment at-will. Only the Board of Directors
of VaxGen has the authority to amend this Agreement, and then only in a writing
that is signed by both Francis and VaxGen pursuant to authority expressly
granted by VaxGen’s Board of Directors.

16. TERMINATION OF EMPLOYMENT.

A. Subject to the survivability provisions of Section 17 below, Francis’s
employment under this Agreement and all compensation and benefits provided for
herein shall terminate upon the occurrence of any of the following events:

  (1) Death: In the event of Francis’s death, the termination shall be effective
upon the date thereof.

  (2) Disability: In the event that Francis should become “disabled.” For
purposes of this paragraph “disabled” shall mean Francis’s inability to perform
his duties hereunder for a period of four (4) consecutive months, and failure to
resume the performance of such duties on a full-time basis within thirty (30)
days of notice from VaxGen of intent to terminate this Agreement on such
grounds). The termination shall be effective upon the date specified in VaxGen’s
notice to Francis as provided for herein.

  (3) Cause: VaxGen may terminate this Agreement upon the occurrence of “cause”
for termination as herein defined. “Cause” shall mean (a) Francis’s willful
commission of an act of fraud, misappropriation, embezzlement, misrepresentation
or other illegal or improper act that has the effect of injuring VaxGen or its
reputation; (b) Francis’s commission of a material violation of VaxGen’s
policies, practices and procedures, including its sexual harassment,
discrimination and/or substance abuse policy or commission of a breach of any
provision of this Agreement, including the confidential information and
invention assignment provisions herein, and, if such violation is curable,
Francis’s failure to cure such violation within 15 business days of receiving
notice of such violation by the Board of Directors; (c) Francis’s habitual
failure to perform his job duties, as determined by the Board of Directors in
its reasonable judgment, and after notice of such failure has been given to
Francis by the Board of Directors and Francis has had a 15 business-day period
within which to cure such failure; and/or (d) any other reason deemed “cause”
under applicable California law. The Parties acknowledge that the reference to a
“for Cause” termination herein does not alter the employment at-will
relationship, but merely sets forth circumstances under which the Company has no
obligation to pay severance to Francis. The termination shall be effective upon
the date specified in VaxGen’s notice to Francis.

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  (4) Without Cause: Either VaxGen or Francis may terminate this Agreement
without Cause at any time upon thirty (30) days written notice to the other
party. The termination shall be effective upon the date specified in the notice
given pursuant hereto.

  (5) By Francis with Good Reason: Francis may terminate his employment under
this Agreement in the event VaxGen breaches a material term hereof and, after
receiving written notice of the alleged breach from Francis does not remedy said
breach within thirty (30) days of receiving notice. The termination shall be
effective on the date specified in the notice given hereunder.

B. In the event that this Agreement is terminated by VaxGen under paragraphs
(A)(1), (A)(2) or (A)(3) above, or by Francis under paragraph (A)(4) above, no
severance pay will be due to Francis.

C. In the event that this Agreement is terminated by VaxGen under paragraph
(A)(4) above or by Francis under paragraph (A)(5) above, Francis shall be
entitled to receive: (i) severance pay in the amount of six (6) months of his
then-existing annual base salary plus one additional month of base salary for
each full year of employment with VaxGen (such severance being limited strictly
to annual base salary and will not include any amount paid or payable as a bonus
or stock option grant) up to a maximum severance payment of twelve (12) months
annual base salary, less required and authorized deductions, payable on VaxGen’s
ordinary payroll cycles until fully paid out; and (ii) accelerated vesting of
all his outstanding stock options to fully vested status as of the date of
termination.

D. Francis shall be entitled to the severance benefits provided for in Paragraph
16.C above if, within twelve (12) months following a Change in Control (as
defined below), VaxGen or its successor in interest terminates Francis’s
employment for any reason other than for Cause (as defined above) or Francis
terminates his employment on account of any of the following: (i) there is a
material reduction in Francis’s job duties or responsibilities, including,
without limitation, demotion from the position of President; or (ii) VaxGen or
its successor in interest moves Francis’s principal place of business more than
thirty-five (35) miles from VaxGen’s current principal place of business at 1000
Marina Blvd, Brisbane, California; or (iii) there is a reduction in Francis’s
then-current base salary and/or performance bonus opportunity. For purposes of
this Agreement, a “Change in Control” shall be deemed to have occurred in the
case of a sale of all or substantially all of VaxGen’s capital stock in a single
transaction or series of related transactions, sale of all or substantially all
of VaxGen’s assets, or consolidation or merger of VaxGen with or into another
corporation, entity or person if, after giving effect to the consolidation or
merger, the former stockholders of VaxGen own less than 50% of the capital stock
of the surviving corporation.

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17. INDEMNIFICATION. VaxGen shall maintain, for the benefit of Francis, director
and officer liability insurance in form at least as comprehensive as, and in an
amount that is at least equal to, that maintained by VaxGen as of the Effective
Date of this Agreement. In addition, Francis shall be indemnified by VaxGen
against liability as an officer and director of VaxGen or any subsidiary or
affiliate of VaxGen to the maximum extent permitted by applicable law. Francis’s
rights under this Paragraph 17 shall continue so long as he may be subject to
such liability, whether or not his employment may have terminated prior thereto.

18. SURVIVABILITY. The respective rights and obligations of the Parties
hereunder, including, without limitation, Sections 7, 8, 9, 10, 11, 12, 13, 14,
16(C), 17, 19 and 28 of this Agreement, shall, to the extent necessary, survive
any termination of Francis’s employment or this Agreement.

19. GOVERNING LAW. This Agreement shall be construed in accordance with and
governed by the laws of the State of California without regard to its conflict
of law rules. This Agreement shall be interpreted in accordance with the plain
meaning of its terms and not strictly for or against either party.

20. ENTIRE AGREEMENT. This Agreement embodies the complete agreement and
understanding of the parties related to Francis’s employment by VaxGen,
superseding any and all other prior or contemporaneous oral or written
agreements between the parties hereto with respect to the employment of Francis
by VaxGen, and contains all of the covenants and agreements of any kind
whatsoever between the parties with respect to such employment. Each party
acknowledges that no representations, inducements, promises or agreements,
whether oral or written, express or implied, have been made by either party or
anyone acting on behalf of a party, that are not incorporated herein and that no
agreement or promise not contained herein shall be valid or binding.

21.WAIVER. The failure of either party to insist, in any one or more instances,
upon performance of the terms or conditions of this Agreement shall not be
construed as a waiver or a relinquishment of any right granted under this
Agreement or of the future performance of any such term, covenant or condition.

22. INVALIDITY. Should any provision, portion or part of this Agreement be held
by a court of competent jurisdiction to be invalid, void or unenforceable, the
remaining provisions, portions or parts shall be unaffected and shall continue
in full force and effect, and said invalid, void or unenforceable provision(s),
portion(s) or part(s) shall be deemed not to be part of this Agreement.

23. NO THIRD PARTY BENEFICIARIES. This Agreement is not intended by either party
to create any third-party beneficiaries, and shall not be so construed in any
proceeding. The sole parties to this Agreement are Francis and VaxGen, and it is
their mutual intent that they alone shall have standing to enforce the
provisions of this Agreement, subject to the provisions of Section 26 below.

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24. VOLUNTARY AGREEMENT. Francis and VaxGen represent and agree that each has
reviewed all aspects of this Agreement, has carefully read and fully understands
all provisions of this Agreement, and is voluntarily entering into this
Agreement. Each party represents and agrees that such party has had the
opportunity to review any and all aspects of this Agreement with the legal, tax
or other advisor or advisors of such party’s choice before executing this
Agreement.

25. CAPTIONS. The captions of the various paragraphs of this Agreement are
placed herein for the convenience of the parties and the reader, do not
constitute a substantive term or terms of this Agreement, and shall not be
considered in any issue involving the interpretation or application of this
Agreement.

26. SUCCESSORS AND ASSIGNS. This Agreement shall be binding upon and inure to
the benefit of and shall be enforceable by and against Francis’s heirs,
beneficiaries and legal representatives. It is agreed that the rights and
obligations of Francis may not be delegated or assigned except as specifically
set forth in this Agreement. In the event of a Change in Control (as defined
above), VaxGen may assign its rights and obligations under this Agreement to its
successor-in-interest, and in that event such successor-in-interest shall be
deemed to have acquired all rights and assumed all obligations of VaxGen under
this Agreement.

27. NOTICES. Notices given under the terms of this Agreement shall be in writing
and shall be deemed delivered when personally delivered to the person identified
below, or three (3) days after deposited, proper first class postage prepaid, in
the U. S. Mail and addressed as set forth below, or one day after properly
consigned to a recognized national next-day delivery service (e.g., Federal
Express) prepaid and addressed as set forth below, or faxed to the number
provided below and confirmed by a delivery report from the sending fax
transmitter. The VaxGen officer, addresses and facsimile numbers below may be
changed by written notice given pursuant to this paragraph. Notices shall be
given

If to VaxGen: Chairman of the Board of Directors of VaxGen
1000 Marina Blvd., Suite 200
Brisbane, CA. 94005
Fax number: 650-624-1001

If to Francis Dr. Donald Francis
1000 Marina Blvd., Suite 200
Brisbane, CA. 94005
Fax number: 650-624-1001

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28. ALTERNATIVE DISPUTE RESOLUTION PROGRAM. Except as to efforts to seek
injunctive relief as specifically addressed in paragraphs 7 through 14, the
parties understand and agree that any dispute arising out of Francis’s
employment by VaxGen, the termination of that employment, or arising out of or
relating to this Agreement shall be submitted to binding arbitration in
accordance with the terms of the Alternative Dispute Agreement set forth in
Appendix  B to this Agreement and incorporated herein.

Dated:
——————————————  
——————————————
Donald P. Francis, M.D., D.Sc.

Dated:
——————————————   VaxGen, Inc.

By:
——————————————
Title:
——————————————

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APPENDIX A

Inventions. Except as set forth below, I hereby acknowledge that at this time I
have no right, title or other interest in any invention, patent, copyright or
other such material other than the following (if none, so state):

Dated:
——————————————  
——————————————
Donald P. Francis, M.D., D.Sc.

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APPENDIX B

ALTERNATIVE DISPUTE AGREEMENT

I. AGREEMENT TO ARBITRATE

       In the event that any employment dispute arises between VaxGen, Inc.
(“VaxGen”) and Donald P. Francis, M.D., D.Sc. (“Francis”), the parties involved
will make all efforts to resolve any such dispute through informal means. If
these informal attempts at resolution fail andif the dispute arises out of or is
related to Francis’s Employment Agreement, Francis’s employment, the termination
of Francis’s employment or alleged unlawful discrimination, including but not
limited to sexual or other unlawful harassment (an “Arbitrable Dispute”), VaxGen
and Francis will submit the dispute to final and binding arbitration, except as
set forth in Paragraphs 7-14 of the Employment Agreement.

       The parties expressly understand and agree that arbitration is the
exclusive remedy for all such Arbitrable Disputes; with respect to such
disputes, no other action may be brought in court or any other forum (except
actions to compel arbitration or enforce an award issued hereunder). THIS
ALTERNATIVE DISPUTE RESOLUTION (“ADR”) AGREEMENT IS A WAIVER OF THE PARTIES’
RIGHTS TO A CIVIL COURT ACTION FOR A DISPUTE RELATING TO BREACH OF THE PARTIES’
EMPLOYMENT AGREEMENT, TERMINATION OF THAT EMPLOYMENT OR ALLEGED UNLAWFUL
DISCRIMINATION, WHICH INCLUDES RETALIATION OR SEXUAL OR OTHER UNLAWFUL
HARASSMENT; ONLY AN ARBITRATOR, NOT A JUDGE OR JURY, WILL DECIDE THE DISPUTE.

       Arbitrable Disputes arising out of or related to employment, or the
termination of such employment or alleged unlawful discrimination, including
retaliation or sexual or other unlawful harassment, shall include, but not be
limited to, the following: alleged violations of federal, state and/or local
constitutions, statutes or regulations; claims based on any purported breach of
contractual obligation, including breach of the covenant of good faith and fair
dealing; and claims based on any purported breach of duty arising in tort,
including violations of public policy.

       The following types of employment disputes are not subject to this ADR
Agreement: (1) disputes related to workers’compensation and unemployment
insurance; (2) claims for benefits covered by a separate benefit plan that
provides for arbitration; and (3) claims subject to Sections 7 through 14 of the
Employment Agreement. Also, nothing in the Employment Agreement or in the ADR
Agreement shall be construed as precluding Francis from filing a charge with the
Equal Employment Opportunity Commission (“EEOC”), the National Labor Relations
Board (“NLRB”) or other federal, state or local agencies, seeking administrative
assistance in resolving claims. However, any claim that cannot be resolved
administratively through such an agency shall be subject to the Employment
Agreement and the ADR Agreement.

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II. REQUEST FOR ARBITRATION

     A. Attempt At Informal Resolution Of Disputes

       Prior to the submission of any Arbitrable Dispute to arbitration, Francis
and VaxGen shall attempt to resolve the dispute informally as set forth below.

       Francis and VaxGen will select a mediator from a list provided by the
Federal Mediation and Conciliation Service or other similar agency who will
assist the parties in attempting to reach a settlement of the dispute. The
mediator may make settlement suggestions to the Parties but shall not have the
power to impose a settlement upon them. If the dispute is resolved in mediation,
the matter shall be deemed closed. If the dispute is not resolved in mediation
and goes to the next step (binding arbitration), any proposals or compromises
suggested by either of the parties or the mediator shall not be referred to in
or have any bearing on the arbitration procedure. The mediator cannot also serve
as the arbitrator in the subsequent proceeding unless all parties expressly
agree in writing.

     B. Arbitration Procedures

       The party desiring arbitration, whether Francis or VaxGen, must submit a
“Request For Arbitration” in writing to the other party within the time period
required by the law that applies to the claim under the applicable statute of
limitations. If the “Request for Arbitration” is not submitted in accordance
with the aforementioned time limitations, the party failing to do so will not be
able to bring his claims to this or any other forum. The requesting party may
use a “Request for Arbitration” form supplied by VaxGen (Appendix C).
Alternatively, the requesting party may create a “Request For Arbitration” form
that, unless otherwise required by law, clearly states “Request For Arbitration”
at the beginning of the first page and includes the following information:

       1. A factual description of the dispute in sufficient detail to advise
the other party of the nature of the dispute;

       2. The date when the dispute first arose;

       3. The names, work locations and telephone numbers of any individuals,
including employees or supervisors, with knowledge of the dispute; and

       4. The relief requested by requesting party.

       The responding party may submit counterclaim(s) in accordance with
applicable law.

     C. Selection Of The Arbitrator

       All disputes will be resolved by a single Arbitrator, the Arbitrator will
be mutually selected by VaxGen and Francis. If the parties cannot agree on an
Arbitrator, then a list of seven (7) arbitrators, experienced in employment
matters, shall be provided by the Judicial Arbitration Mediation Services
(“JAMS/Endispute”). The Arbitrator will be selected by the parties who will
alternately strike names from the list. The last name remaining on the list will
be the Arbitrator selected to resolve the dispute. Upon selection, the
Arbitrator shall set an appropriate time, date and place for the arbitration,
after conferring with the parties to the dispute.

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     D. The Arbitrator’s Authority

       The Arbitrator shall have the powers enumerated below:

       1. Ruling on motions regarding discovery, and ruling on procedural and
evidentiary issues arising during the arbitration.

       2. Ruling on motions to dismiss and/or motions for summary judgment
applying the standards governing such motions under the Federal Rules of Civil
Procedure.

       3. Issuing protective orders on the motion of any party or third party
witness. Such protective orders may include, but are not limited to, sealing the
record of the arbitration, in whole or in part (including discovery proceedings
and motions, transcripts, and the decision and award), to protect the privacy or
other constitutional or statutory rights of parties and/or witnesses.

       4. Determining only the issue(s) submitted to him/her. The issue(s) must
be identifiable in the “Request For Arbitration”or counterclaim(s). Except as
required by law, any issue(s) not identifiable in those documents is outside the
scope of the Arbitrator’s jurisdiction and any award involving such issue(s),
upon motion by a party, shall be vacated.

     E. Discovery

       The discovery process shall proceed and be governed by the standards of
the California Code of Civil Procedure and the Federal Arbitration Act. Each
party may obtain discovery necessary to adequately explore and arbitrate their
respective claims. The Arbitrator shall have the power to enforce the
aforementioned discovery rights and obligations by the imposition of the same
terms, conditions, consequences, liabilities, sanctions and penalties as can or
may be imposed in like circumstances in a civil action under the California Code
of Civil Procedure, except the power to order the arrest or imprisonment of a
person.

     F. Hearing Procedure

       The hearing shall be held at a location mutually agreed upon by the
parties, or as determined by the Arbitrator in the absence of an agreement, and
shall proceed according to the current version of the American Arbitration
Association’s “National Rules for the Resolution of Employment Disputes ”(the
“Rules”) with the following amendments:

       1. The Arbitrator shall rule at the outset of the arbitration on
procedural issues that bear on whether the arbitration is allowed to proceed.

       2. Each party has the burden of proving each element of its claims or
counterclaims, and each party has the burden of proving any of its affirmative
defenses.

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       3. In addition to, or in lieu of closing argument, either party shall
have the right to present a post-hearing brief, and the due date for exchanging
any post-hearing briefs shall be mutually agreed on by the parties and the
Arbitrator, or determined by the Arbitrator in the absence of agreement.

       4. The Rules shall otherwise be modified to the extent necessary to be
consistent with applicable law.

     G. Substantive Law

       1. The parties agree that they will be afforded the identical legal,
equitable, and statutory remedies as would be afforded them were they to bring
an action in a court of competent jurisdiction.

       2. The applicable substantive law shall be the law of the State of
California and/or federal law. Choice of substantive law in no way affects the
procedural aspects of the arbitration, which are exclusively governed by the
provisions of this ADR Agreement.

     H. Opinion And Award

       The Arbitrator shall issue a written opinion and award, in conformance
with the following requirements:

       1. The opinion and award must be signed and dated by the Arbitrator.

       2. The Arbitrator’s opinion and award shall decide all issues submitted.

       3. The Arbitrator’s opinion and award shall set forth the findings of
fact and conclusions of law supporting each part of the opinion.

       4. The Arbitrator shall have the same authority to award remedies,
damages and costs as provided to a judge and/or jury under parallel
circumstances.

     I. Enforcement Of Arbitrator’s Award

       Following the issuance of the Arbitrator’s decision, any party may
petition a court to confirm, enforce, correct or vacate the Arbitrator’s opinion
and award under the Federal Arbitration Act, and/or applicable State law.

     J. Fees And Costs

       Unless otherwise required by law, fees and costs shall be allocated in
the following manner:

       1. Each party shall be responsible for its own attorneys’fees, except as
otherwise provided by law for the particular claim(s) at issue.

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       2. VaxGen shall pay the entire cost of the arbitrator’s services, the
facility in which the arbitration is to be held, and any similar costs that
Francis would not have otherwise incurred if the dispute was adjudicated in a
court of law rather than through arbitration.

       3. VaxGen shall pay the entire cost of a court reporter to transcribe the
arbitration proceedings. Each party shall advance the cost for said party’s
transcript of the proceedings. Each party shall advance its own costs for
witness fees, service and subpoena charges, copying, or other incidental costs
that each party would bear during the course of a civil lawsuit.

       4. Each party shall be responsible for its costs associated with
discovery, except as required by law or court order.

III. SEVERABILITY

       Each term, clause and provision of this ADR Agreement is separate and
independent, and should any term, clause or provision of this ADR Agreement be
found to be invalid or unenforceable, the validity of the remaining terms,
clauses, and provisions shall not be affected. As to those terms, clauses and
provisions found to be invalid or unenforceable, they shall be replaced with
valid and enforceable terms, clauses or provisions or shall be modified, in
order to achieve, to the fullest extent possible, the economic, business and
other purposes of the invalid or unenforceable terms, clauses or provisions.

DATED:
                ————————————  
——————————————
Donald P. Francis, M.D., D.Sc.

DATED:
                ————————————   VaxGen, Inc.

By:
——————————————
Title:
——————————————

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APPENDIX C

REQUEST FOR ARBITRATION FORM

ALTERNATIVE DISPUTE RESOLUTION AGREEMENT

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Submission
Requirement   This form (or, alternatively, a form that includes the information
below) must be submitted by the individual claimant to the CEO within the time
period required by the law that applies to the claim. If VaxGen requests
arbitration, the form must also be served on the individual within the
appropriate time period.

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State the nature of the claim in detail:

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(Continue on reverse and add pages if necessary)

Enter the date of termination or date(s) of alleged incident(s) (i.e., date of
last instance of unlawful discrimination, sexual or other unlawful harassment):
_______/________/_______
Month          Day            Year

Provide the names and work locations of any individuals, including employees or
supervisors, with knowledge of the dispute:

Name Job Title Work Location

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Describe the relief requested (i.e., what you want done):

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(Please attach any documents relevant to the dispute.)

Signature of Party Requesting Arbitration:

DATED:
                ————————————  
——————————————
Donald P. Francis, M.D., D.Sc.

— or —

DATED:
——————————————   VaxGen, Inc.

By:
——————————————
Title:
——————————————