SECOND AMENDMENT TO SECURITIES PLEDGE AGREEMENT

        THIS SECOND AMENDMENT TO SECURITIES PLEDGE AGREEMENT (“Amendment”) is
made effective this 22 day of February, 2006 by and between LASALLE BUSINESS
CREDIT, LLC, successor by merger to LaSalle Business Credit, Inc., as Agent
(“Agent”) for LASALLE BANK MIDWEST NATIONAL ASSOCIATION (“Lender”) and MTS
MEDICATION TECHNOLOGIES, INC. (formerly known as Medical Technology Systems,
Inc., the “Pledgor”).

BACKGROUND

A.     Agent, Pledgor and Lifeserve Technologies, Inc. (which has subsequently
dissolved) previously entered into that certain Securities Pledge Agreement
dated June 26, 2002 (as amended by that certain First Amendment to Securities
Pledge Agreement dated July 8, 2003 and as the same may be further amended from
time to time, the “Pledge Agreement”).

B.     Agent and Pledgor desire to amend the Pledge Agreement in accordance with
the terms and conditions set forth herein.

C.     Capitalized terms used herein and not otherwise defined shall have the
meanings provided for such terms in the Pledge Agreement.

        NOW THEREFORE, the parties hereto, intending to be legally bound hereby,
agree as follows:

        1.    Confirmation of Background. Pledgor does hereby ratify, confirm
and acknowledge that the statements contained in the foregoing Background are
true, accurate and complete in all respects and that the Pledge Agreement, as
modified and amended hereby, is valid, binding and in full force and effect as
of the date hereof and fully enforceable against Pledgor and its respective
assets in accordance with the terms thereof.

       2.     Pledged Shares. Schedule I of the Pledge Agreement is hereby
deleted in its entirety, and replaced with Schedule A attached hereto.

       3.     Ratification and Confirmation. As amended hereby, all of the terms
and conditions of the Pledge Agreement, all documents in connection therewith
and all liens, security interests, rights and remedies granted therein, remain
in full force and effect and are hereby ratified, confirmed and continued as
security for all obligations of Pledgor or to Agent and/or Lender.

        4.     Binding Effect. This Amendment shall be binding upon the
successors and assigns of Pledgor and shall inure to the benefit of the
successors and assigns of Agent and Lender.

        5.     Severability. The provisions of this Amendment are deemed to be
severable and the invalidity or unenforceability of any provision shall not
affect or impair the remaining provisions which shall continue in full force and
effect.

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        6.     Governing Law. This Agreement shall be governed by and construed
in accordance with the internal laws and decisions of the Commonwealth of
Pennsylvania without regard to conflict of law principles. Unless otherwise
defined herein, terms defined in Articles 8 and 9 of the Pennsylvania Uniform
Commercial Code are used herein as therein defined. Whenever possible, each
provision of this Agreement shall be interpreted in such manner as to be
effective and valid under applicable law, but, if any provision of this
Agreement shall be interpreted in such manner as to be ineffective or invalid
under applicable law, such provisions shall be ineffective or invalid only to
the extent of such prohibition or invalidity, without invalidating the remainder
of such provision or the remaining provisions of this Agreement.

        7.     Headings. The headings of this Amendment are inserted for
convenience only and shall not be deemed to constitute a part of this Amendment.

        IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be
executed effective as of the day and year first above written.

        MEDICATION MANAGEMENT TECHNOLOGIES, INC.        By:

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    Name/Title:

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          LASALLE BUSINESS CREDIT, LLC, successor by merger     to LaSalle
Business Credit, Inc., as Agent for     LaSalle Bank Midwest National
Association        By:

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    Name/Title:

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2

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SCHEDULE A

Certificate No.   No. Shares   Issure   Record Owner

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         3       1,000 shares   Medication Management Systems, Inc.   MTS
Medication Technologies, Inc. 3       1,000 shares   Medication Management
Technologies, Inc.   MTS Medication Technologies, Inc. 1       100 shares  
Medical Technology Laboratories, Inc.   MTS Medication Technologies, Inc. 1  
    100 shares   MTS Packaging Systems, Inc.   MTS Medication Technologies, Inc.
1       65 shares   MTS Medication Technologies Limited (formerly known as MTS
Packaging Systems International Ltd.)   MTS Medication Technologies, Inc.