EXHIBIT 10.1

SECOND AMENDMENT OF LOAN AND SECURITY AGREEMENT

This SECOND  AMENDMENT OF LOAN AND SECURITY AGREEMENT (“Amendment”) is dated as
of June 15, 2007, by and between Synthetech, Inc., an Oregon Corporation, having
a place of business at 1290 Industrial Way Albany, OR  97322 (“Borrower”) and
ACCESS BUSINESS FINANCE LLC, having a principal place of business at 14205 S. E.
36th Street, Suite 350, Bellevue, WA  98006 (“Lender”).

RECITALS

A.           Borrower and Lender have entered into that certain Loan and
Security Agreement dated as of June 15, 2006 (as amended or modified to the date
hereof, the “Loan Agreement”).

B.           Borrower has requested that Lender amend, and Lender has agreed to
amend, the Loan Agreement to:

1.  
    Increase the Inventory sublimit of the Borrowing Base to $1,500,000 from
$975,000;

2.  
    Decrease the Interest Rate from Prime + 3% to Prime;

3.  
    Reduce the Annual Loan Fee from 1%  to .75%;

4.  
    Reduce the Minimum Monthly Charge from $5,000 to $2,500;

5.  
    Borrower will be required to submit its internal monthly financial
statements to Lender by the 30th day of each month;

6.  
    All inventory reporting will be required by the 30th day of each month.

NOW, THEREFORE, in consideration of the premises, and intending to be legally
bound hereby, the parties hereby agree as follows:

AGREEMENT

1.           Amendment of the Loan Agreement.  The Loan Agreement is hereby
amended as follows, effective as of the date hereof:

1.1           The term “Borrowing Base” is amended and shall read in its
entirety: “Borrowing Base – the sum of: 1.2.11.1 (i) Eighty-Five (85%) percent
of the Net Face Amount of Borrower’s Eligible Accounts, plus the lesser of (1)
Forty (40%) percent of the Value of Eligible Inventory, (2) $1,500,000.00 or N/A
of the Net Face Amount of Borrower’s Eligible Accounts.”
1.2           The term “Interest Rate” is amended and shall read in its
entirety: “Prime Rate.  Any change in the Interest Rate shall be effective as of
the date of any change in the Prime Rate.”
1.3           The term “Loan Fee” is amended and shall be reduced to .75% of the
Maximum Amount at the time this fee accrues.
1.4           The term “Minimum Monthly Income” is amended and shall be reduced
to $2,500.00.
1.5           Paragraph 10.3.2.4 is added and shall read in its entirety:
“Borrower's balance sheet as of the close of each month and its income statement
for that portion of the then current fiscal year through the end of each month
no later than Thirty (30) days after the close of each month;”
1.6           Paragraph 10.3.4 is amended and shall read in its entirety: “A
listing of all Borrower's Inventory, based upon weekly physical cycle counts,
within Thirty (30) days after the close of each month.

2.           Modification.  Except as expressly modified hereby, the Loan
Agreement shall remain unchanged and in full force and effect.

3.           Conflicts.  If a conflict exists between the provisions of the Loan
Agreement and the provisions of this Amendment, the provisions of this Amendment
shall control.

4.           Further Assurances.  Borrower agrees to make and execute such other
documents as may be necessary or required to effectuate the terms and conditions
of this Agreement.

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5.           Future Modifications.  This Amendment does not entitle, or imply
any consent or agreement to, any further or future modification of, amendment
to, waiver of, or consent with respect to any provision of the Loan Agreement.

6.           Severability.  In the event any one or more of the provisions
contained in this Agreement is held to be invalid, illegal or unenforceable in
any respect, then such provision shall be ineffective only to the extent of such
prohibition or invalidity, and the validity, legality, and enforceability of the
remaining provisions contained herein shall not in any way be affected or
impaired thereby.

7.           Headings.  Section headings and numbers have been set forth for
convenience only.

8.           Counterparts.  This Amendment may be signed in any number of
counterparts, each of which shall be an original, with the same effect as if all
signatures were upon the same instrument.  Delivery of an executed counterpart
of the signature page to this Amendment by telefacsimile shall be effective as
delivery of a manually executed counterpart of this  Amendment, and any party
delivering such an executed counterpart of the signature page to this Amendment
by telefacsimile to any other party shall thereafter also promptly deliver a
manually executed counterpart of this Amendment to such other party, provided
that the failure to deliver such manually executed counterpart shall not affect
the validity, enforceability, or binding effect of this Agreement.

IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly
executed and delivered by their respective officers thereunto duly authorized as
of the date first above written.
 

 
 

 Synthetech, Inc.                 By:       
Gary Weber
   Title:   VP Finance, CFO        
ACCESS BUSINESS FINANCE, LLC  
             By:              Title: