Exhibit 10.198

 

AMENDMENT NO. 2 TO EMPLOYMENT AGREEMENT

 

THIS AMENDMENT NO. 2 (the “Amendment”), made as of this 1st day of January, 2003
(the “Effective Date”), by and between PPD Development, LP (“PPD Development”)
and W. Richard Staub (“Employee”), amends that certain Employment Agreement
dated May 1, 2002 between PPD Development and Employee, as heretofore amended
(the “Employment Agreement”).

 

FOR AND IN CONSIDERATION OF the mutual promises, covenants and conditions
contained herein, and other good and valid consideration, the receipt and
sufficiency of which is hereby acknowledged, the parties hereby amend the
Employment Agreement as follows:

 

1. Amendment to Section 4. The first sentence of Section 4 of the Employment
Agreement is hereby stricken and replaced in full by the following: “Employee
shall have overall responsibility for business development of (a) PPD
Development and all of its subsidiaries except Pharmaco Investments, Inc., (b)
PPD Global Ltd. (other than its informatics business), (c) Leicester Clinical
Research Centre Ltd., (d) ProPharma Pte Ltd, (e) ProPharma Asia Ltd and (f)
ProPharma CRO Pty Ltd (collectively, the “Businesses”).

 

2. New Appendix I. All references to Appendix I in the Employment Agreement
shall be deemed to refer to Appendix I attached to this Amendment.

 

3. Binding Effect. The Employment Agreement, as herein amended, shall continue
in full force and effect.

 

IN WITNESS WHEREOF, the parties have executed this Amendment as of the date
first above written.

 

PPD DEVELOPMENT, LP

   

By: PPD GP, LLC, its general partner

   

By:

 

/s/ Fred B. Davenport, Jr.

--------------------------------------------------------------------------------

   

Name:

 

Fred B. Davenport, Jr.

   

Title:

 

Vice President

   

/s/ W. Richard Staub

--------------------------------------------------------------------------------

 

(SEAL)

W. Richard Staub