Exhibit 10.23

 

SUPPLEMENTAL AGREEMENT

REGARDING CDX AGREEMENT AND COLLABORATION AGREEMENT AND SIXTH AMENDMENT TO
COLLABORATION AGREEMENT

 

This Supplemental Agreement Regarding CDx Agreement and Collaboration Agreement
And Sixth Amendment to Collaboration Agreement   (this “Supplemental Agreement”)
is entered into as of January 6, 2016 (the “Effective Date”) by and among
Medivation, Inc., a Delaware corporation having offices located at 525 Market
Street, 36th Floor, San Francisco, CA 94105, United States, its wholly owned
subsidiary Medivation Prostate Therapeutics, Inc., a Delaware corporation having
offices located at [the same location] (such entities, collectively,
“Medivation”), Astellas Pharma Inc., a Japanese corporation having offices
located at 2-5-1, Nihonbashi Honcho, Chuo Ku, Tokyo 103- 8411, Japan (“API”) and
its indirect wholly owned subsidiary Astellas US LLC, a Delaware limited
liability company having office located at 1 Astellas Way, Northbrook, Illinois
60062, United States (collectively with API, “Astellas”).  Medivation and
Astellas are sometimes referred to herein individually as a “Party” and
collectively as the “Parties”.

Background

Medivation and Astellas entered into a Collaboration Agreement dated October 26,
2009, as amended January 1, 2010, May 13, 2011, April 1, 2013, October 29, 2013,
and May 6, 2014 (the “Collaboration Agreement”).

NanoString Technologies, Inc. (“NanoString”), Medivation, Inc. and its
Affiliates (as defined in the CDx Agreement; collectively with Medivation, Inc.,
“MDV”), and API entered into a Collaboration Agreement effective as of January
6, 2016 (the “CDx Agreement”).

Medivation and Astellas desire to provide for certain supplemental terms with
respect to their rights and obligations pursuant to the CDx Agreement and the
Collaboration Agreement, and to clarify the intended interplay of certain terms
of the CDx Agreement and the Collaboration Agreement.

NOW, THEREFORE, in consideration of the foregoing premises and the mutual
covenants contained in this Supplemental Agreement, the Parties hereby agree as
follows:

Article 1

Definitions

As used in this Supplemental Agreement, the following initially capitalized
terms, whether used in the singular or plural form, shall have the meanings set
forth in this Article 1.  Unless otherwise provided herein, any capitalized term
used but not defined herein shall have the meaning provided in the Collaboration
Agreement.  In addition, the terms “includes,” “including,” “include” and
derivative forms of them shall be deemed followed by the phrase

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[*] = Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

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“without limitation” (regardless of whether it is actually written there (and
drawing no implication from the actual inclusion of such phrase in some
instances after such terms but not others)) and the term “or” has the inclusive
meaning represented by the phrase “and/or” (regardless of whether it is actually
written (and drawing no implication from the actual use of the phrase “and/or”
in some instances but not in others)).  Unless otherwise stated, dollar amounts
set forth herein are U.S. dollars.

1.1  “API CDx IP” means (a) Background IP (as defined in the CDx Agreement) of
API or its Affiliates, and (b) API’s interest in and to (i) Joint Project IP (as
defined in the CDx Agreement), (ii) Medivation/Astellas Project IP (as defined
in the CDx Agreement), and (iii) Medivation/Astellas Project Data (as defined in
the CDx Agreement).

1.2“CDx” has the meaning ascribed to such term in the CDx Agreement.

1.3“CDx Joint Patent” has the meaning ascribed to the term “Joint Patent” in the
CDx Agreement.

1.4“CDx JSC” has the meaning ascribed to the term “JSC” in the CDx Agreement.

1.5“Inventions” has the meaning ascribed to such term in the CDx Agreement.

1.6 “IVD” has the meaning ascribed to such term in the CDx Agreement.

1.7“Joint Project IP” has the meaning ascribed to such term in the CDx
Agreement.

1.8“Losses” has the meaning ascribed to such term in the CDx Agreement.

1.9“MDV CDx IP” means (a) Background IP (as defined in the CDx Agreement of MDV
or its Affiliates, and (b) MDV’s interest in and to (i) Joint Project IP (as
defined in the CDx Agreement), (ii) Medivation/Astellas Project IP (as defined
in the CDx Agreement), and (iii) Medivation/Astellas Project Data (as defined in
the CDx Agreement).

1.10“Medivation/Astellas Project IP” has the meaning ascribed to such term in
the CDx Agreement.

Article 2

Governance

2.1CDx JSC Voting.  In light of the fact that Medivation and Astellas [*] at the
CDx JSC, Medivation and Astellas agree that [*] shall be cast in accordance with
the following principles:

(a)If the Parties agree in writing [*], then both Parties shall cast [*] at the
CDx JSC in accordance with such agreement.  If the Parties do not agree in
writing [*], [*].

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[*] = Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

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(b)If the Parties do not agree in writing [*], and the vote pertains solely to
the Licensed Territory [*], including the Development or Commercialization of
the CDx solely for the Licensed Territory, then [*].  

(c)If the Parties do not agree in writing [*], and the vote pertains to a matter
other than an [*], then the JSC shall promptly attempt to resolve such
disagreement in accordance with Section 2.7 of the Collaboration Agreement
(including the rights of the Parties to determine such matter, if applicable,
under Sections 2.7(b)(i) and (ii) and referral to Executive Officers set forth
in Section 2.7(c)), in each case taking account of the timing of such decision
as may be required to comply with the CDx Agreement.  For so long as the Parties
remain deadlocked with respect to any decision within the jurisdiction of the
CDx JSC after compliance with the foregoing procedures, [*], and the [*]
procedures set forth in [*] and [*] of the CDx Agreement shall apply as to the
decision to be made by the CDx JSC.

2.2Regulatory Matters.  The Parties agree that, as between Medivation and
Astellas, all decisions in respect of regulatory strategy in relation to any
Product (including Regulatory Issues) shall be governed by Articles 2 and 4 and
the other terms and conditions of the Collaboration Agreement, notwithstanding
anything to the contrary set forth in the CDx Agreement, including Section
4.1(b) of the CDx Agreement.  In exercising any rights or approvals of
Medivation or Astellas pursuant to the CDx Agreement, each Party shall exercise
such right or grant such approval consistent with the foregoing.  

2.3Other Joint Decisions, Rights and Actions.  Except as otherwise provided in
this Article 2 or in Article 3 or 9 of this Supplemental Agreement, wherever the
CDx Agreement provides for a decision to be made, a right to be exercised
(including a consent right) or an action to be taken, in each case by Medivation
and Astellas collectively (excluding any decision, right or action to be taken
by “each of” Medivation and Astellas), and the Parties do not agree on such
decision, the exercise of such right or the taking of such action, then such
decision, right or action shall be made, exercised or taken in accordance with
the principles set forth in Section 2.1, except that (i) the concept of casting
of the [*] vote at the JSC shall be replaced with the concept of making such
decision, exercising such right or taking such action and (ii) the statement in
the last sentence of Section 2.1(c) of this Supplemental Agreement that the “[*]
procedures set forth in [*] … of the CDx Agreement shall apply” shall be
disregarded.  If the Parties agree in writing on such decision, the exercise of
such right or the taking of such action, either Party may make such decision,
exercise such right or take such action for purposes of the CDx Agreement.  

2.4Joint Obligations.  For clarity, when the phrases “Medivation or Astellas”
(other than at the end of a list or as part of any defined term) or “Medivation
and Astellas” are used in the CDx Agreement in the context of an obligation to
be performed under the CDx Agreement, and such obligation does not reasonably
pertain to only one such Party in the context in which it is used, both
Medivation and Astellas shall be obligated to the other to comply with such
obligation.

3

 

[*] = Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

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2.5Coordination.  The Parties shall cooperate with each other to implement
reasonable procedures to streamline [*] decisions, actions, rights and
obligations under the CDx Agreement in accordance with this Article 2.

Article 3

Allocation of Costs

3.1Cost Sharing of Compensation.  As between Medivation and Astellas, all
amounts to be paid by Medivation or Astellas to NanoString under the CDx
Agreement (other than Article 14 thereof or for breach thereof), including the
Technology Access Fee (as defined in the CDx Agreement), development costs
(including Development Costs (as defined in the CDx Agreement)), and milestone
payments (for purposes of this Supplemental Agreement, any such amounts due to
NanoString may be referred to as “Compensation”), shall be paid by Medivation or
Astellas to NanoString as provided in this Section 3.1:

(a)with respect to Compensation consisting of the Technology Access Fee due
pursuant to Section 8.1 of the CDx Agreement and the [*] pursuant to Section
11.1(c) of the CDx Agreement, such amounts shall be paid by [*] and [*] of such
amounts shall be reimbursed by [*];

(b)with respect to Compensation consisting of Development Costs due pursuant to
Section 8.2 of the CDx Agreement or any additional amounts which may be due
pursuant to Section 3.3(b)(ii) of the CDx Agreement, such amounts shall be paid
by [*] and [*] of such amounts shall be reimbursed by [*];

(c)with respect to Compensation consisting of the milestone payment due pursuant
to Sections 8.3[*] of the CDx Agreement, such amounts shall be paid by [*] and
[*] of such amounts shall be reimbursed by Astellas;

(d)with respect to Compensation consisting of the milestone payment due pursuant
to Sections 8.3[*] of the CDx Agreement, such amounts shall be paid by [*] and
shall [*];

(e)with respect to Compensation consisting of (i) any milestone payment due
pursuant to the penultimate sentence of Section 8.3 of the CDx Agreement based
on [*], and (ii) as set forth in Section 8.6 of the CDx Agreement, any amounts
due to NanoString pursuant to Section 3.7 of the CDx Agreement as reimbursement
for costs and expenses incurred with respect to [*], such amounts shall be paid
by [*] and shall [*];

(f)with respect to Compensation consisting of the [*] due pursuant to Section
12.2 of the CDx Agreement based on the [*] of the CDx Agreement in the United
States as a result of [*]  pursuant to Section 9.1 of this Supplemental
Agreement, such amount shall be paid by [*] and [*] of such amount shall be
reimbursed by [*];

4

 

[*] = Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

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(g)with respect to Compensation consisting of other amounts due to NanoString
from Medivation and Astellas pursuant to the CDx Agreement (excluding for
purposes of this Section 3.1(g) (i) any amounts due as damages or other
liability (including an arbitration award) for breach of the CDx Agreement by
Medivation or Astellas and (ii) any amounts due pursuant to Section 14.2 or 14.3
of the CDx Agreement), such amounts shall be (A) paid by [*] and [*] shall be
reimbursed by [*] if such amounts that relate to the [*], (B) paid by [*] and
[*]  shall be reimbursed by [*] if such amounts relate to the [*], (C) [*] shall
be paid by [*] and [*]  if such amounts relate [*], or (D) as the Parties may
otherwise agree in writing.

3.2 Right of Payment to NanoString and Related Reimbursement.  Each of
Medivation and Astellas will endeavor to timely pay each Compensation payment
due and owing under the CDx Agreement in accordance with the foregoing cost
sharing.   However, on account of the joint liability for Compensation set forth
in Section 8.6 of the CDx Agreement, each of Medivation and Astellas may pay any
Compensation to NanoString that is due and owing by the other Party to the
extent such other Party has not paid its portion of such Compensation in a
timely fashion.  In such event, the Party that failed to pay the full amount of
its portion of the Compensation due and owing to NanoString shall promptly
reimburse the other Party for any amount paid by such other Party on the
non-paying Party’s behalf or, at the option of such other Party upon notice to
the non-paying Party, such other Party shall have the right to offset any amount
that was paid by such other Party on the non-paying Party’s behalf pursuant to
this Section 3.2 against any payments owned by such other Party to the
non-paying Party under the Collaboration Agreement or this Supplemental
Agreement.  

3.3Interest.  Each of Medivation and Astellas shall bear the full amount of any
interest due on any late payment under Section 8.7 of the CDx Agreement to the
extent arising from the portion of the Compensation for which it is responsible
under the Collaboration Agreement.

3.4Relationship of Section 8.5 of the CDx Agreement to the Collaboration
Agreement.  Notwithstanding anything contained in Section 8.5 of the CDx
Agreement, as between Astellas and Medivation, with respect to costs and
expenses incurred by such Party in the performance of its obligations under the
CDx Agreement in connection with the Project, if and to the extent such costs
and expenses would constitute Joint Commercialization Costs, Joint Development
Costs, Joint Medical Affairs Costs or Manufacturing Costs pursuant to the
Collaboration Agreement if incurred by such Party thereunder, such amounts shall
constitute Joint Commercialization Costs, Joint Development Costs, Joint Medical
Affairs Costs or Manufacturing Costs, as applicable, under the Collaboration
Agreement and be subject to the terms and conditions thereof.

3.5Amounts Not Recharacterizable Under Collaboration Agreement. In the case of
any costs identified in Section 3.1 of this Supplemental Agreement, neither
Party shall have any right to charge, characterize or recharacterize such
amounts as Joint Development Costs, Joint Medical Affairs Costs or Joint
Commercialization Costs under the Collaboration Agreement.

5

 

[*] = Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

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Article 4

Intellectual Property

4.1Sole Project IP and Joint Project IP.  Subject to Section 4.2:

(a)Ownership.  The Parties agree that as between MDV and API:

(i)all Medivation/Astellas Project IP or Joint Project IP that is jointly
conceived, discovered, developed or otherwise made, as necessary to establish
authorship, inventorship or ownership under Applicable Law (hereinafter
“Conceived”) by either Medivation or Astellas (but not both) and NanoString
shall constitute (or be deemed to constitute) Sole Inventions of the Party that
Conceived such Medivation/Astellas Project IP or Joint Project IP;

(ii)except as set forth in section 4.1(a)(i), all Medivation/Astellas Project IP
shall constitute (or be deemed to constitute) Joint Inventions of the Parties
under the Collaboration Agreement; and

(iii)ownership of all other Inventions Conceived under the CDx Agreement shall
be determined pursuant to Section 10.1 of the Collaboration Agreement as though
such other Inventions were inventions Conceived under the Collaboration
Agreement.

(b)Prosecution of Joint Project IP First Controlled by NanoString.  The Parties
agree that, as between MDV and API, with respect to Joint Project IP in which
(i) both Medivation and Astellas have a joint interest under the CDx Agreement
and (ii) NanoString has the first right to prepare patent applications covering
such Joint Project IP and to file and Prosecute and Maintain (as defined in the
CDx Agreement) such patent applications, and any resulting CDx Joint Patents in
any jurisdiction, if NanoString provides written notice to MDV and API of
NanoString’s intent to abandon, cease prosecution or otherwise not file or
maintain any such CDx Joint Patent in any jurisdiction worldwide, MDV’s and
API’s rights and obligations to each other with respect to prosecution and
maintenance of such CDx Joint Patent shall be subject to the terms and
conditions of the Collaboration Agreement, including Sections 10.3 and 10.5
thereof, with such CDx Joint Patent treated as a Joint Patent under the
Collaboration Agreement.  The rights and obligations between MDV or API, on the
one hand, and NanoString, on the other hand, with respect to such CDx Joint
Patents shall continue to be governed by the CDx Agreement.

(c)Enforcement of CDx Joint Patents First Controlled by NanoString.  The Parties
agree that, as between MDV and API, with respect to CDx Joint Patents in which
(i) both Medivation and Astellas have a joint interest under the CDx Agreement
and (ii) NanoString has the first right to bring an appropriate suit or other
action to enforce such CDx Joint Patents against any person or entity allegedly
engaged in infringement of such CDx Joint Patents, if NanoString notifies MDV
and API of NanoString’s intent to not so elect (or settle or otherwise secure
the abatement of such infringement), then MDV’s and API’s rights and obligations
to

6

 

[*] = Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

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each other with respect to enforcement of such CDx Joint Patent shall be subject
to the terms and conditions of the Collaboration Agreement, including Sections
10.4 and 10.5 thereof, with such CDx Joint Patent treated as a Joint Patent
under the Collaboration Agreement.  The rights and obligations between MDV or
API, on the one hand, and NanoString, on the other hand, with respect to such
CDx Joint Patents shall continue to be governed by the CDx Agreement.

4.2Medivation/Astellas Project Data.  Notwithstanding anything to the contrary
in the Collaboration Agreement, the Parties agree that as between MDV and API,
all Medivation/Astellas Project Data under the CDx Agreement shall constitute
(or be deemed to constitute) a Joint Invention of the Parties under the
Collaboration Agreement (whether or not NanoString also jointly conceived,
discovered, developed or otherwise made such Medivation/Astellas Project Data).

4.3Confirmatory Assignment.  Each Party shall, and does hereby, assign, and
shall cause its Affiliates to so assign, to the other Party, without additional
compensation, such right, title and interest in and to any Joint Project IP,
Medivation/Astellas Project IP and Medivation/Astellas Project Data as well as
any intellectual property rights with respect thereto, as is necessary to fully
effect any rights of joint ownership provided for in Section 4.1(a) or Section
4.2 of this Supplemental Agreement.  Subject to the licenses and rights of
reference granted by a Party to the other Party in the Collaboration Agreement,
this Supplemental Agreement or the CDx Agreement, each Party shall have the
right to Exploit any jointly-owned Joint Project IP, Medivation/Astellas Project
IP and Medivation/Astellas Project Data without a duty of seeking consent or
accounting to the other Party.

Article 5

Licenses

5.1Licenses to Astellas.  Without limitation to the rights and licenses granted
by Medivation to Astellas in the Collaboration Agreement:

(a)MDV hereby grants to API a non-exclusive, worldwide, paid-up, royalty-free,
sublicensable (through multiple tiers) license under the MDV CDx IP to the
extent reasonably necessary or useful for API to perform its obligations under
the CDx Agreement.

(b)MDV hereby grants to API a non-exclusive, worldwide, paid-up, royalty-free,
sublicensable (through multiple tiers) license under the MDV CDx IP to the
extent reasonably necessary or useful for API to Exploit any IVD, including any
CDx, for use with any Product.  The licenses granted in this Section 5.1(b) and
in Section 8.1 of the Collaboration Agreement, include a license for Astellas to
Exploit Products with reference to or in conjunction with any IVD, including the
CDx.

(c)MDV hereby grants to API a perpetual, non-exclusive, worldwide, paid-up,
royalty-free, sublicenseable (through multiple tiers) license and “right of
reference” in and to, including the right to cross-reference, file or
incorporate by reference, any regulatory

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[*] = Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

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documentation or any Regulatory Approvals (as defined in the CDx Agreement)
Controlled by MDV with respect to any IVD, including any CDx, intended for use
with any Product, for purposes of the Exploitation of any Product with reference
to or in conjunction with any IVD, including any CDx, and the Exploitation of
any IVD, including any CDx, for use with any Product.

5.2Licenses to Medivation.  Without limitation to the rights and licenses
granted by Astellas to Medivation in the Collaboration Agreement:

(a)API hereby grants to MDV a non-exclusive, worldwide, paid-up, royalty-free,
sublicensable (through multiple tiers) license under the API CDx IP to the
extent reasonably necessary or useful for MDV to perform its obligations under
the CDx Agreement.

(b)API hereby grants to MDV a non-exclusive, paid-up, royalty-free,
sublicensable (through multiple tiers) license, in the Shared Territory, under
the API CDx IP to the extent reasonably necessary or useful for MDV to Exploit
any IVD, including any CDx, for use with any Product.

Article 6

Confidentiality

6.1Collaboration Agreement Governs Confidentiality Obligations.  The Parties
hereby agree that this Section 6.1 shall govern MDV’s and API’s rights and
obligations (if any) to each other with respect to any information or materials
that (in the absence of this Section 6.1) qualify as Confidential Information of
MDV or API under the CDx Agreement, and that this Section 6.1 shall apply in
lieu of any rights or obligations that Medivation or Astellas would otherwise
have to the other pursuant to Sections 9.1 through 9.4 of the CDx Agreement
(Confidentiality) or other terms and conditions of the CDx Agreement that
provide for rights and obligations of Medivation or Astellas in relation to the
other, with respect to Confidential Information of MDV or API under the CDx
Agreement.  In the case of any information or materials that (in the absence of
this Section 6.1) qualify as “Confidential Information” of Medivation or
Astellas pursuant to the CDx Agreement, as between Medivation and Astellas, such
information and material shall constitute (or be deemed to constitute)
“Confidential Information” of the applicable Party under the Collaboration
Agreement only if and to the extent such information or materials would qualify
as Confidential Information under the Collaboration Agreement if disclosed by
Medivation or Astellas to the other under the Collaboration Agreement.  Any such
information or material that so qualifies shall be subject to Article 13 of the
Collaboration Agreement. The rights and obligations between MDV or API, on the
one hand, and NanoString, on the other hand, with respect to Confidential
Information (as defined in the CDx Agreement) shall continue to be governed by
the CDx Agreement.

6.2Medivation/Astellas Project Data.  Without limiting Section 4.2, as between
the Parties, all Medivation/Astellas Project Data under the CDx Agreement is
hereby deemed Product Information under the Collaboration Agreement, regardless
of whether or not such

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[*] = Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

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Medivation/Astellas Project Data relates specifically to Collaboration Molecules
or Products, or the Exploitation thereof.  MDV’s and API’s rights and
obligations to each other with respect to such Medivation/Astellas Project Data
shall be subject to the terms and conditions of the Collaboration Agreement, to
the same extent as if such Medivation/Astellas Project Data were Product
Information under the Collaboration Agreement.  The rights and obligations
between MDV or API, on the one hand, and NanoString, on the other hand, with
respect to Medivation/Astellas Project Data shall continue to be governed by the
CDx Agreement.

Article 7

Indemnification and Limitation of Liability

7.1Indemnification of NanoString by Medivation and Astellas.  If either
Medivation or Astellas are obligated to indemnify NanoString under Article 14 of
the CDx Agreement:

(a)to the extent the Losses under the CDx Agreement for which such
indemnification is owing (or has been provided) constitute Shared Program
Damages under the Collaboration Agreement, such Losses shall be borne equally by
each of Medivation and Astellas to the extent provided by Section 12.4 of the
Collaboration Agreement;

(b)to the extent the Losses under the CDx Agreement for which such
indemnification is owing (or has been provided) would constitute Astellas
Damages resulting from Astellas Claims subject to indemnification by Medivation
under Section 12.1 of the Collaboration Agreement, such Losses shall be borne by
Medivation to the extent provided in Article 12 of the Collaboration Agreement;
and

(c)to the extent the Losses under the CDx Agreement for which such
indemnification is owing (or has been provided) would constitute Medivation
Damages resulting from Medivation Claims subject to indemnification by Astellas
under Section 12.2 of the Collaboration Agreement, such Losses shall be borne by
Astellas to the extent provided in Article 12 of the Collaboration Agreement.

7.2Indemnification of Medivation by Astellas. In order to provide for
indemnification of Medivation Indemnitees by Astellas for certain matters in
relation to the CDx Agreement:

(a)Article 1 of the Collaboration Agreement shall be amended to add to the
following defined term: “NanoString Agreement” means the Collaboration Agreement
dated as of January 6, 2016, by and among NanoString Technologies, Inc.,
Medivation and Astellas.”;

(b)Section 12.2(b) of the Collaboration Agreement is hereby amended to add the
following, before the semicolon and after “this Agreement”: “or under the
NanoString Agreement”;

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[*] = Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

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(c)Section 12.2(c) of the Collaboration Agreement is hereby amended to add the
following, before the semicolon and after “Sublicensees”:  “in performing its
obligations or exercising its rights under this Agreement or the NanoString
Agreement”; and

(d)Section 12.2(d) of the Collaboration Agreement is hereby amended to add the
following, before the semicolon and after “Sublicensees”:  “in performing its
obligations or exercising its rights under this Agreement or the NanoString
Agreement”.

7.3Indemnification of Astellas by Medivation. In order to provide for
indemnification of Astellas Indemnitees by Medivation for certain matters in
relation to the CDx Agreement:

(a)Section 12.1(a)(i) is hereby amended to add the following, before the
semicolon and after “this Agreement”: “or under the NanoString Agreement”;

(b)Section 12.1(a)(ii) of the Collaboration Agreement is hereby amended to add
the following, before the semicolon and after “sublicensees”:  “in performing
its obligations or exercising its rights under this Agreement or the NanoString
Agreement”; and

(c)Section 12.2(a)(iv) of the Collaboration Agreement is hereby amended to add
the following, before the semicolon and after “sublicensees”:  “in performing
its obligations or exercising its rights under this Agreement or the NanoString
Agreement”.

7.4Shared Program Activities / Shared Program Damages.  For purposes of this
Supplemental Agreement and the Collaboration Agreement, “Shared Program
Activities” shall have the meaning set forth in the Collaboration Agreement,
provided that activities with respect to a Collaboration Molecule or Product
shall be understood to include activities with respect to a Product that consist
of activities directed to the development or commercialization of (i) the CDx
for use with the Product or (ii) the Product for use in conjunction with the
CDx.

7.5Other Claims Between the Parties.  As between Medivation and Astellas, the
[*] contained in Section 14.8 of the CDx Agreement (including [*] set forth
therein) shall not apply to any claim, suit, proceeding or cause of action
between Astellas and Medivation arising under or in connection with the
Collaboration Agreement and/or the CDx Agreement, it being agreed that that
Astellas and Medivation shall be subject only to the limitations on liability
set forth in the Collaboration Agreement (including Section 16.11 thereof) with
respect to any claim, suit, proceeding or cause of action between the Parties
arising under or in connection with the CDx Agreement and/or the Collaboration
Agreement.

Article 8

Dispute Resolution

8.1Coordination. To the extent there are related disputes under the
Collaboration Agreement and the CDx Agreement that in each case have been
referred to [*], the Parties will

10

 

[*] = Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

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endeavor to coordinate the resolution of all such disputes, including to the
extent practicable by having the same [*] determine the disputed matters in
similar timeframes.

8.2Resolution of Disputes.  Each of Medivation and Astellas agree that, except
to the extent relating to the CDx, involving NanoString, or arising from a
breach of the CDx Agreement, disputes between Medivation and Astellas (including
in respect of Clinical Trials) shall to the extent practicable be resolved in
accordance with the Collaboration Agreement rather than the CDx Agreement.

Article 9

Termination Matters

9.1Exercise of Right of [*] under the CDx Agreement.  The Parties acknowledge
that, pursuant to Section 12.2 of the CDx Agreement, Medivation and Astellas
jointly have the right to [*] the CDx Agreement with respect to [*] upon [*]
written notice to NanoString.  Notwithstanding the joint nature of this right,
in the event that [*] notifies [*] in writing that [*] desires to [*] the CDx
Agreement [*], [*] shall cooperate with [*] and deliver to NanoString the notice
required pursuant to Section 12.2 of the CDx Agreement to effect [*].  [*] shall
provide such notice to NanoString jointly with [*] no more than [*] after
receipt of notice from [*] requesting same.

Article 10

Miscellaneous

10.1Ownership of nCounter Systems.  The Parties agree that they shall jointly
own (in equal shares) and hold title to the nCounter systems purchased under
Section 8.2(a)(iii)(A) of the CDx Agreement.  

10.2Coordination of Audits.  The Parties agree that they shall use good faith
efforts to coordinate audits under Section 6.2 of the CDx Agreement, including
to take account of audits required in support of Exploitation of the CDx in
conjunction with the Product in the United States and the Licensed Territory. 
Furthermore, the [*] permitted under Section 6.2(b) of the CDx Agreement shall
be allocated as follows: (a) during the Initial Clinical Trial, Medivation shall
have the right to appoint [*] and Astellas shall have the right to appoint [*];
and (b) upon Commercialization and thereafter, Medivation shall have the right
to appoint [*] and Astellas shall have the right to appoint [*].

10.3Medivation Affiliates.  Medivation, Inc. shall cause its Affiliates (as
defined in the CDx Agreement as parties to the CDx Agreement) to be bound by the
terms and conditions of this Supplemental Agreement.

10.4Entire Agreement; Amendment.  This Supplemental Agreement, together with the
terms and conditions of the CDx Agreement that contain rights and obligations of
MDV and

11

 

[*] = Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

--------------------------------------------------------------------------------

API in relation to one another, and the Collaboration Agreement, sets forth the
complete, final and exclusive agreement and all the covenants, promises,
agreements, warranties, representations, conditions and understandings between
the Parties hereto with respect to the subject matter hereof and supersede all
prior agreements and understandings between the Parties existing as of the
Effective Date with respect to the subject matter hereof.  Notwithstanding the
preceding sentence, the Parties intend for the CDx Agreement and the
Collaboration Agreement to remain in full force and effect, subject to the terms
and conditions of this Supplemental Agreement.  No subsequent alteration,
amendment, change or addition to this Supplemental Agreement shall be binding
upon the Parties unless reduced to writing and signed by an authorized officer
of each Party.

10.5Assignment.  Neither Party may assign or transfer this Supplemental
Agreement or any rights or obligations hereunder without the prior written
consent of the other, except that a Party may make such an assignment without
the other Party’s consent to Affiliates or to a successor to which such Party
assigns its rights and obligations under the Collaboration Agreement in
accordance with the terms and conditions thereof.  Any permitted successor or
assignee of rights and/or obligations hereunder shall, in a writing to the other
Party, expressly assume such rights and/or obligations (and in any event, any
Party assigning this Supplemental Agreement to an Affiliate shall remain bound
by the terms and conditions hereof).  Any permitted assignment shall be binding
on the successors of the assigning Party.  Any assignment or attempted
assignment by either Party in violation of the terms of this Section 10.5 shall
be null, void and of no legal effect.

10.6Other Provisions.  Sections 16.2 (Force Majeure), 16.3 (Notices), 16.4 (No
Strict Construction; Headings), 16.8 (Performance by Affiliates), 16.9 (Further
Actions), 16.12 (Severability), 16.13 (No Waiver), 16.14 (Independent
Contractors) and 16.15 (Counterparts),  of the Collaboration Agreement, and
Article 15 (Dispute Resolution) of the Collaboration Agreement, shall apply to
this Supplemental Agreement on a mutatis mutandis basis.

[Signature Page Follows]

 

12

 

[*] = Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

--------------------------------------------------------------------------------

 

In Witness Whereof, the Parties have executed this Supplemental Agreement in
duplicate originals by their duly authorized officers as of the Effective Date.

 

Medivation, Inc. (on behalf of itself

and its Affiliates (as defined in the CDx

Agreement))

 

Astellas Pharma Inc.

 

 

 

 

 

By:

/s/ Andrew Powell

 

By:

 

 

 

 

 

 

Name:

Andrew Powell

 

Name:

 

 

 

 

 

 

Title:

Secretary

 

Title:

 

 

 

 

 

 

 

 

 

 

 

Medivation Prostate Therapeutics, Inc.

 

Astellas US LLC

 

 

 

 

 

By:

/s/ Andrew Powell

 

By:

 

 

 

 

 

 

Name:

Andrew Powell

 

Name:

 

 

 

 

 

 

Title:

Secretary

 

Title:

 

 

Supplemental Agreement

--------------------------------------------------------------------------------

 

In Witness Whereof, the Parties have executed this Supplemental Agreement in
duplicate originals by their duly authorized officers as of the Effective Date.

 

Medivation, Inc. (on behalf of itself

and its Affiliates (as defined in the CDx

Agreement))

 

Astellas Pharma Inc.

 

 

 

 

 

By:

 

 

By:

/s/ Chihiro Yokota

 

 

 

 

 

Name:

 

 

Name:

Chihiro Yokota

 

 

 

 

 

Title:

 

 

Title:

Executive Vice President

 

 

 

 

 

 

 

 

 

 

Medivation Prostate Therapeutics, Inc.

 

Astellas US LLC

 

 

 

 

 

By:

 

 

By:

 

 

 

 

 

 

Name:

 

 

Name:

 

 

 

 

 

 

Title:

 

 

Title:

 

 

 

Supplemental Agreement

--------------------------------------------------------------------------------

 

In Witness Whereof, the Parties have executed this Supplemental Agreement in
duplicate originals by their duly authorized officers as of the Effective Date.

 

Medivation, Inc. (on behalf of itself

and its Affiliates (as defined in the CDx

Agreement))

 

Astellas Pharma Inc.

 

 

 

 

 

By:

 

 

By:

 

 

 

 

 

 

Name:

 

 

Name:

 

 

 

 

 

 

Title:

 

 

Title:

 

 

 

 

 

 

 

 

 

 

 

Medivation Prostate Therapeutics, Inc.

 

Astellas US LLC

 

 

 

 

 

By:

 

 

By:

/s/ Masao Yoshida

 

 

 

 

 

Name:

 

 

Name:

Masao Yoshida

 

 

 

 

 

Title:

 

 

Title:

President and CEO

 

 

 

 

Supplemental Agreement