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Exhibit 10.32

Amendment No. 1
to
Amended and Restated Employment Agreement

This Amendment No. 1 to the Amended and Restated Employment Agreement, dated
November 8, 2004 (the "Agreement"), between Vertex Pharmaceuticals Incorporated,
a Massachusetts corporation (together with its successors and assigns, the
"Company") and Kenneth S. Boger (the "Executive") is entered into by the parties
on February 11, 2008. The parties hereby agree that the Agreement shall be
amended as follows:

A. A new Section 10(c)(x) shall be added, which shall state in its entirety as
follows:

(x)if the termination of employment to which this Section 10(c) applies occurs
within 90 days prior to a Change of Control or within 12 months after a Change
of Control:

(a)all stock options that are not exercisable upon the application of the
provisions of Section 10(c)(vi) shall immediately become exercisable in full and
the options to which this provision applies shall remain exercisable until the
earlier of (1) the end of the 90-day period immediately following the later of
the date of employment termination or the date of the Change of Control and
(2) the date the stock option(s) would otherwise expire; and

(b)the Company's lapsing repurchase right with respect to shares of restricted
stock held by the Executive shall lapse in full (subject to the Executive making
satisfactory arrangements with the Company providing for payment to the Company
of all required withholding taxes).

B. A new Section 27 shall be added, which shall state in its entirety as
follows:

27.409A.

Any severance payment to the Executive under this Agreement shall be bifurcated
into two portions, consisting of a portion that does not constitute
"nonqualified deferred compensation" within the meaning of Section 409A of the
Code and a portion, if any, that does constitute nonqualified deferred
compensation. If the Executive is a "specified employee" as defined in
Section 409A(a)(2)(B)(i) of the Code, the commencement of the delivery of any
such payments that constitute nonqualified deferred compensation payable upon a
"separation from service" under Section 409A(a)(2)(A)(i) of the Code will be
delayed until the later of (i) the first business day that is more than six
months after the employment termination date and (ii) the date such payments
would otherwise be payable hereunder. The determination of whether, and the
extent to which, any of the payments to be made to the Executive hereunder are
nonqualified deferred compensation shall be made after the application of all
applicable exclusions, including those set forth under Treasury
Reg. § 1.409A-1(b)(9). Any payments that are intended to qualify for the
exclusion for separation pay due to involuntary separation from service set
forth in Reg. §1.409A-1(b)(9)(iii) must be paid no later than the last day of
the second taxable year following the taxable year in which the employment
termination date occurs. To the extent that the termination of the Executive's
employment does not constitute a separation of service under
Section 409A(a)(2)(A)(i) of the Code (as the result of further services that are
reasonably anticipated to be provided by the Executive to the Company at the
time the Executive's employment is terminated), the payment of any non-qualified
deferred compensation will be further delayed until the later of (i) date the
first business day that is more than six months after the date of a subsequent
event constituting a separation of service under Section 409A(a)(2)(A)(i) of the
Code and (ii) the date such payments would otherwise be payable hereunder.

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As so amended, the Agreement shall remain in full force and effect. Executed as
of the date set forth above:

    VERTEX PHARMACEUTICALS INCORPORATED
 
 
By:
 
          /s/  IAN SMITH      

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Ian Smith
Executive Vice President and Chief Financial Officer
 
 
 
 
 
 
 
 
 
/s/  KENNETH S. BOGER      

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Kenneth S. Boger

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Exhibit 10.32