THIS EXHIBIT HAS BEEN REDACTED AND IS THE SUBJECT OF A CONFIDENTIAL TREATMENT
REQUEST. REDACTED MATERIAL IS MARKED WITH [***] AND HAS BEEN FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION.

AMENDMENT N°1 TO
OPTION FOR A LICENSE AGREEMENT
 

THIS AMENDMENT N°1 (hereinafter referred to as the “Amendment N°1”) entered into
as of the 14th day of June, 2017 (the “Amendment N°1 Effective Date”) by and
between MacroGenics, Inc. a Delaware corporation having a place of business at
9704 Medical Center Drive, Rockville, MD, USA 20850 (“MacroGenics”), and Les
Laboratoires Servier, a company organized and existing under the laws of France,
having a principal office located at 50 rue Carnot 92284 Suresnes (“LLS”) and
Institut de Recherches Servier, a company organized and existing under the laws
of France, having a principal office located at 3 rue de la Republique - 92150
Suresnes - France (“IdRS”) and LLS and IdRS hereinafter collectively referred to
as “Servier”).
MacroGenics and Servier are each referred to herein by name or as a “Party” or,
collectively, as “Parties.”
WHEREAS, Servier and MacroGenics are parties to the Option for a License
Agreement, dated September 19, 2012 (hereinafter referred to as the
“Agreement”), which set forth notably the terms and conditions of an option
grant and an exclusive license to enable Servier to research, develop and
commercialize DARTS mentioned in the Agreement, upon exercise of the exclusive
option by Servier with respect to such DARTS;
WHEREAS, Servier and MacroGenics wish to execute an Amendment N°1 to the
Agreement, in accordance with Section 16.10 of the Agreement, in order to
provide for alternate terms with respect to certain of the Parties’ rights and
obligations under Section 7.1.1 of the Agreement
NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency
of which is hereby acknowledged, the Parties agree to the following terms and
conditions:
All capitalized terms used in this Amendment N°1 but not otherwise defined
herein, shall have the meanings ascribed to such terms in the Agreement.

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THIS EXHIBIT HAS BEEN REDACTED AND IS THE SUBJECT OF A CONFIDENTIAL TREATMENT
REQUEST. REDACTED MATERIAL IS MARKED WITH [***] AND HAS BEEN FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION.

1. TRANSFER OF MACROGENICS MANUFACTURING KNOW-HOW FOR [***]

Section 7.1.1 of the Agreement is hereby amended to add the following as the
second sentence of such Section:
“Notwithstanding the foregoing, for the [***] designated as [***] which is
included in the [***], upon a decision of the Joint Manufacturing Committee
(“JMC”) (a subcommittee of the JSC established in accordance with Section 2.5.3)
and on a schedule and a product comparability plan agreed upon by the JMC,
MacroGenics shall disclose (and provide copies, as applicable) to either Servier
or a Third Party manufacturer that is mutually acceptable to both Parties, all
MacroGenics Know-How necessary or useful to enable Servier or such Third Party
manufacturer (as appropriate) to Manufacture applicable Licensed Product
included in the [***] based on a manufacturing process determined by
MacroGenics.”

2. TERM

This Amendment N°1 shall be effective on the Amendment N°1 Effective Date and
ends at the expiration of the Agreement.

3. OTHER TERMS AND CONDITIONS OF THE AGREEMENT

All other terms and conditions of the Agreement not modified by the Amendment
N°1 shall remain unaltered and given full force and effect.

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THIS EXHIBIT HAS BEEN REDACTED AND IS THE SUBJECT OF A CONFIDENTIAL TREATMENT
REQUEST. REDACTED MATERIAL IS MARKED WITH [***] AND HAS BEEN FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION.
IN WITNESS WHEREOF, the Parties, intending to be legally bound, have caused this
Amendment to be executed by their respective duly authorized representatives as
of the Amendment Effective Date.

MACROGENICS, INC. By: [***] Name: [***] Title: [***] LES LABORATOIRES
SERVIER By: [***] Name: [***] Title: [***] By: [***] Name: [***] Title: [***] INSTITUT
DE RECHERCHES SERVIER By: [***] Name: [***] Title: [***]