Exhibit 10.269

SIXTH LEASE AMENDMENT TO LEASE AGREEMENT

THIS SIXTH LEASE AMENDMENT TO LEASE AGREEMENT (hereinafter referred to as the
“Amendment”) is made as of the 6th day of February 2006, by and between DUKE
REALTY LIMITED PARTNERSHIP, an Indiana limited partnership doing business in
North Carolina as Duke Realty of Indiana Limited Partnership (hereinafter
referred to as “Landlord”) and PPD DEVELOPMENT LP, a Texas limited partnership
and successor in interest to PPD Development, Inc. (hereinafter referred to as
“Tenant”).

WITNESSETH:

WHEREAS, pursuant to a Lease Agreement dated January 28, 1998 by and between
Landlord and Tenant, and as amended by that certain First Amendment to Lease
Agreement dated July 9, 1997, and as amended by that certain Second Amendment to
Lease Agreement dated June 26, 1998, and as amended by that certain First
Amendment to Lease Agreement dated February 18, 1999, and as amended by that
certain Fourth Amendment to Lease Agreement July 6, 1999, and as further amended
by that certain Fifth Amendment to Lease Agreement dated October 1, 2002
(collectively the Lease Agreement, and all amendments thereto shall be referred
to herein collectively as the “Lease”), Landlord leased to Tenant certain
premises containing approximately 100,987 rentable square feet in a building
located on certain land (the “Land”) at 3900 North Paramount Parkway,
Morrisville, Wake County, North Carolina 27560 (the “Premises”), all as more
particularly described in the Lease; and

WHEREAS, the parties hereto desire to modify the Rent Adjustment for the entire
Premises as set forth in the Fifth Lease Amendment to Lease Agreement; and

WHEREAS, the parties hereto desire to amend the Lease, among other things, to
reflect such modification; and

NOW, THEREFORE, for and in consideration of Ten Dollars ($10.00) paid by
Landlord and Tenant to one another, and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged by
Landlord and Tenant, Landlord and Tenant amend the Agreement as follows:

1. Base Rent, Operating Expenses and Security Deposit.

(a) The following sentence of Article 2(a) of that certain Fifth Lease Amendment
to Lease Agreement is deleted in its entirety

“On November 8, 2008, Tenant’s base rent shall be adjusted to the then current
Market Rent (as defined in the Lease) and taking into account the readjustment
of the operating expenses as set out in paragraph 2(b) below; provided, however,
that in no event shall the base rent per square foot, as adjusted, be less than
Tenant’s then current rent.”

and replaced with the following:

“On November 9, 2008 (the “Rent Adjustment Date”), Tenant’s Base Rent for the
entire Premises shall be adjusted to the lesser of (i) an amount equal to one
hundred three percent (103%)

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of the Base Rent per square foot for the twelve (12) month period immediately
preceding the Rent Adjustment Date, or (ii) the then current Market Rent (as
hereinafter defined) and taking into account the readjustment of the operating
expenses as set out in Paragraph 2(b)(ii) of the Fifth Lease Amendment to Lease
Agreement; provided, however, that in no event shall the Base Rent per square
foot, as adjusted, be less than Tenant’s then current rent. Beginning on
November 9, 2009, Tenant’s Base Rent, as determined above, will be increased by
three percent (3%) for each successive twelve (12) month period through the
expiration of the current Lease term.”

(b) The following sentence of Article 2(b) of that certain Fifth Lease Amendment
to Lease Agreement is deleted in its entirety

“Operating Expenses. Effective on November 8, 2008, Article 2(b)(ii) of the
Lease is hereby amended by deleting the following:”

and replaced with the following:

“Operating Expenses. Effective on November 9, 2008, Article 2(b)(ii) of the
Lease is hereby amended by deleting the following:”

2. Effective Date. The provisions of this Amendment shall be and become
effective as of the date and year first above written.

3. Severability. In the event any term, covenant or condition of this Amendment,
the Lease, or any amendments thereto shall to any extent be invalid or
unenforceable, the remainder shall not be affected thereby and each term,
covenant or condition shall be valid and enforceable to the full extent
permitted by law.

4. Successors and Assigns. This Amendment shall apply to, inure to the benefit
of, and be binding upon the parties hereto and upon their respective heirs,
legal representatives, successors and permitted assigns, except as otherwise
provided herein.

5. Authority of Tenant. Tenant certifies to Landlord that it is authorized to
enter into this Amendment, and that those persons signing below on its behalf
are authorized to do so, and shall promptly upon the request of Landlord provide
a resolution to this effect.

6. Interpretation. Although the printed provisions of this Amendment were
drafted by Landlord, such fact shall not cause this Amendment to be construed
either for or against Landlord or Tenant. All capitalized terms, not otherwise
defined, shall be defined as provided in the Lease.

7. Full Force and Effect. Except as modified hereby, the Lease remains
unmodified and in full force and effect.

8. Governing Law. This Amendment shall be governed by and construed in
accordance with the laws of the State of North Carolina.

9. Mutual Acknowledgment of Non-Existence of Claims. Landlord and Tenant
acknowledge and agree that as of the day hereof there are no known claims by
either party against the other party hereto arising from the relationship as
Landlord and Tenant, respectively, pursuant to the Lease, as amended.

 

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10. Confidentiality. Except as otherwise required by law to be disclosed by
Tenant, the terms and provisions of the Lease and this Amendment are strictly
confidential, are to be shared by Tenant only with its accountant, employees,
and attorneys, and each of those parties shall be advised of the confidential
nature of the lease and this Amendment.

[Execution signatures contained on the following page]

 

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IN WITNESS WHEREOF, the undersigned have caused this Amendment to be executed
under seal and delivered as of the day and year first above written.

 

        LANDLORD:         DUKE REALTY LIMITED PARTNERSHIP, an Indiana limited
partnership doing business in North Carolina as Duke Realty of Indiana Limited
Partnership           By:   Duke Realty Corporation, an Indiana corporation, its
General Partner           By:  

/s/ H. Andrew Kolton

          Name:  

H. Andrew Kolton

          Title:  

Senior VP

ATTEST:       TENANT:   By:  

/s/ Charles H. Munn, Jr.

    PPD DEVELOPMENT LP, a Texas limited partnership   Name:   Charles H. Munn,
Jr.       Title:   Assistant General Counsel             By:   PPD GP, LLC, a
Delaware limited liability company, its General Partner           By:  

/s/ Fred B. Davenport, Jr.

          Name:   Fred B. Davenport, Jr.           Title:   President Guarantor
hereby executes this Amendment to evidence its consent to this Amendment.
ATTEST:       GUARANTOR:         PHARMACEUTICAL PRODUCT DEVELOPMENT, INC., a
North Carolina Corporation   By:  

/s/ Charles H. Munn, Jr.

    By:  

/s/ Fred B. Davenport, Jr.

  Name:   Charles H. Munn, Jr.     Name:   Fred B. Davenport, Jr.   Title:  
Assistant General Counsel     Title:   President

 

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END OF EXECUTION SIGNATURES

 

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