Exhibit 10.8G

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        January 24, 2000

NPS Pharmaceuticals, Inc.
420 Chipeta Way
Salt Lake City, Utah 84108

RE: Amendment Agreement to Amend the November 26, 1997 Amendment Agreement

Dear Sirs:

      This Amendment Agreement to Amend the November 26, 1997 Amendment
Agreement (hereinafter “January 24, 2000 Amendment Agreement”) will confirm that
the Letter Agreement dated November 26, 1997 between NPS Pharmaceuticals, Inc.,
a corporation of the state of Delaware, having a place of business at 420
Chipeta Way, Salt Lake City, Utah 84108, U.S.A. (herein referred to as “NPS”)
and SmithKline Beecham Corporation, a corporation of the Commonwealth of
Pennsylvania, having a place of business at One Franklin Plaza, Philadelphia,
Pennsylvania 19101, U.S.A. (hereinafter referred to as “SB”) shall be amended,
effective as of the date of NPS' signature below, as follows:

  • In the second bullet, delete the “fifth, sixth, and seventh RESEARCH years”
and insert therefor the words “fifth and sixth RESEARCH years”, and at a level
of one hundred seventy five thousand U.S. dollars (U.S. $175,000) per NPS FTE
who is a lab personnel and at a level of one hundred fifty thousand U.S. dollars
(U.S. $150,000) per NPS FTE who is a non–lab based consultant for the seventh
RESEARCH year, provided that it is understood that there will only be a total of
two (2) NPS FTE's during the seventh RESEARCH year, and the levels outlined
above will be applied on a pro-rata basis depending on the type of NPS FTE
utilized.   • This January 24, 2000 Amendment Agreement shall be retroactively
effective as of November 1, 1999.

  •
All other terms and conditions of the Letter Agreement shall remain in full
force and effect.
     

  One Franklin Plaza, PO Box 7929, Philadelphia, PA 19101.Telephone (215) 751
4000. –Fax (215) 751 3400.

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     Please indicate your acceptance of this January 24, 2000 Amendment
Agreement by signing and dating the duplicate copies of this letter below and
returning one such fully executed copy to SB.

          Very truly yours,

          SMITHKLINE BEECHAM CORPORATION

          By: /s/ Donald F. Parman

                       Donald F. Parman           Title: Secretary

          Date: January 24, 2000

AGREED TO AND ACCEPTED:
NPS PHARMACEUTICALS, INC.         By: /s/ E. F. Nemith          E. F. Nemith  
Title: CSO   Date: 1/31/2000  

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