Exhibit 10.218

 

[j0545ex10d218image002.jpg]

 

March 19, 2003

 

Craig W. Carlson

Chief Operating Officer and

Chief Financial Officer

Cygnus, Inc.

400 Penobscot Drive

Redwood City, CA 94063

 

Dear Craig:

 

This letter confirms that Cygnus is not obligated to pay Sankyo the 2002
deferred Advertising and Promotional Amount of $6,688,725.02 under our Sales,
Marketing and Distribution Agreement until second quarter of fiscal year 2004.

 

 

Sincerely,

 

 

 

/s/  John Gargiulo

 

 

 

 

John Gargiulo

 

VP Marketing and Commercial Operations

 

Sankyo Pharma Inc.

 

--------------------------------------------------------------------------------