Exhibit 10.4

 

Confidential treatment has been requested for portions of this exhibit. The copy
filed herewith omits the information subject to the confidentiality request.
Omissions are designated as [***].

 

AMENDMENT NO. 3 TO

LICENSE AGREEMENT

 

THIS AMENDMENT NO. 3 to License Agreement No. 651-01.LIC (“AMENDMENT NO. 3”),
effective as of August 17, 2004 (the “THIRD AMENDMENT DATE”), is entered into by
and between Arizona Science & Technology Enterprises d/b/a Arizona Technology
Enterprises, an Arizona limited liability company having its principal place of
business at 699 S. Mill Avenue, Tempe, AZ 85281 (“AzTE”), acting on behalf of
and for THE ARIZONA BOARD OF REGENTS and ARIZONA STATE UNIVERSITY, of Tempe,
Arizona (“ASU”) and SEATTLE GENETICS, INC., a corporation organized under the
laws of Delaware having its principal place of business located at 21823 30th
Drive S.E., Bothell, WA 98021 (“LICENSEE”).

 

RECITALS

 

WHEREAS, ASU and SGI entered into License Agreement No. 651-01.LIC dated as of
February 3, 2000, as subsequently amended on February 18, 2000 and March 14,
2002 (collectively, the “LICENSE AGREEMENT”);

 

WHEREAS, the parties now wish to amend the LICENSE AGREEMENT on the terms set
forth herein;

 

NOW THEREFORE, in consideration of the mutual covenants set forth below, the
parties amend the LICENSE AGREEMENT and otherwise agree as follows (with all
capitalized terms used but not defined herein having the meanings set forth in
the LICENSE AGREEMENT):

 

AGREEMENT

 

1. ASU acknowledges and agrees that ASU’s [***]. ASU acknowledges and agrees
that the LICENSEE [***] with respect to products utilizing or incorporating
[***].

 

2. Section 2.5 of the LICENSE AGREEMENT is amended and restated to read in its
entirety as follows:

 

“2.5 This Agreement and grant of license hereunder are subject to the terms and
conditions contained throughout this Agreement.”

 

3. Section 5.1.1 of the LICENSE AGREEMENT is amended and restated to read in its
entirety as follows:

 

“The LICENSEE shall pay to ASU the following fees:

 

(a) Within [***] of the THIRD AMENDMENT DATE, a [***] of [***] ($[***]).

 

(b) Beginning in [***], an [***] until expiration of the last to expire of the
VALID CLAIMS within ASU’s PATENT RIGHTS. For purposes of illustration, the [***]
payment schedule shall be as follows:

 

[***]

 

CONFIDENTIAL

--------------------------------------------------------------------------------

3. The provisions of Sections 5.2-5.14, 9.1, 9.2, 9.4 and 9.5 of the LICENSE
AGREEMENT shall apply only to [***], and not [***]. Articles 8 and 14 and
Sections 5.1.3 and 5.1.4 of the LICENSE AGREEMENT are deleted in their
entireties.

 

4. This AMENDMENT NO. 3 is effective for all purposes as of the THIRD AMENDMENT
DATE. Except as otherwise expressly modified by this AMENDMENT NO. 3, the
LICENSE AGREEMENT remains in full force and effect in accordance with its terms.

 

5. This AMENDMENT NO. 3 may be executed in counterparts, each of which shall be
deemed to be an original and together shall be deemed to be one and the same
document.

 

6. [***] (as defined in the LICENSE AGREEMENT) pursuant to a [***]. [***]
represents and warrants that it has all necessary power and authority to [***]
in entering into this AMENDMENT NO. 3, which shall be binding and enforceable in
all respects with regard to [***].

 

[Signature page follows]

 

--------------------------------------------------------------------------------

[***] Confidential treatment has been requested with respect to the omitted
portions.

 

Confidential   -2-    

--------------------------------------------------------------------------------

IN WITNESS WHEREOF, the parties have caused this AMENDMENT NO. 3 to be executed
by their respective duly authorized officers as of the THIRD AMENDMENT DATE.

 

SEATTLE GENETICS, INC.

By:

 

/s/ Clay B. Siegall

--------------------------------------------------------------------------------

   

(Signature)

Name:

 

Clay B. Siegall, Ph.D.

Title:

 

President and Chief Executive Officer

ARIZONA SCIENCE & TECHNOLOGY

ENTERPRISES

By:

 

/s/ Peter Slate

--------------------------------------------------------------------------------

   

(Signature)

Name:

 

Peter Slate

Title:

 

Chief Executive Officer