Exhibit 10.3
[*] = Certain confidential information contained in this document, marked by
brackets, has been omitted because it is both (i) not material and (ii) would
likely be competitively harmful if publicly disclosed.

AMENDMENT NO. 1 TO
AMENDED AND RESTATED COMMERCIAL SUPPLY AGREEMENT
(Amantadine HCl extended release capsules)
This Amendment No. 1 (this “Amendment”) is effective as of June 27, 2019
(“Amendment Effective Date”), by and between Adamas Pharma, LLC, a Delaware
limited liability company, with a place of business at 1900 Powell St., Suite
1000, Emeryville, CA 94608 (“Client”), and Catalent Pharma Solutions, LLC, a
Delaware limited liability company, with a place of business at 14 Schoolhouse
Road, Somerset, New Jersey 08873, USA (“Catalent”).
RECITALS
A.Client and Catalent have entered into an Amended and Restated Commercial
Supply Agreement, effective as of February 16, 2017, as amended, and including
the Notice of Assignment dated July 20, 2017 (collectively the “Amended and
Restated Agreement”).
B.The Parties now desire to amend certain terms of the Amended and Restated
Agreement pursuant to Section 18.1 of the Amended and Restated Agreement.
NOW THEREFORE, in consideration of the mutual covenants, terms and conditions
set forth below, the parties agree as follows:
1.    Attachment B: Attachment B shall be revised per the amended Attachment B
hereto, which shall be made part hereof, of the Amended and Restated Agreement.
More specifically:

(i)
Amantadine HCl Specifications shall be updated.

(ii)
[*] shall be added to the list of Client-Supplied Materials (as such term is
defined in Section 1.17 of the Amended and Restated Agreement). Accordingly, it
shall be removed from the list of Raw Materials.

(iii)
The list of Raw Materials (and sourcing Party for each) shall be updated.

2.    Attachment C: Attachment C shall be revised per the Amended Attachment C
hereto, which shall be made part hereof of the Amended and Restated Agreement.
More specifically:

(i)
The Commercial Manufacturing Pricing for the [*] shall be revised.

(ii)
Campaign sizes in sections A and B adjusted to align with pricing assumptions.

(iii)
Yield averages for the [*] shall be updated to reflect actual value following
process validation. Accordingly, the following sentence shall be deleted:

“Yields will be determined after process validation. This Attachment C will be
updated after process validation at [*], based on actual yields from the
process.”

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(iv)
The third line item which reads “Pricing excludes the cost of API” shall be
replaced with the following sentence: “Pricing excludes the cost of API and [*].

(v)
The Minimum Requirements shall be revised per the amended Attachment C attached
hereto.

[*]

Client additionally agrees to [*] during the term of this Agreement.

3.    Contract Year. The definition for “Contract Year” will be modified to read
as follows:

"Contract Year" means a consecutive 12-month period, computed as follows:

(i)
For Contract Year 1, starting from the Restatement Effective Date and ending
after the 12-month period beginning on the Commencement Date;

(ii)
Beginning with Contract Year 2, the 12-month period beginning at the conclusion
of Contract Year 1 and ending on the second December 31 thereafter; and,

(iii)
Thereafter, each consecutive twelve (12) month period beginning on January 1 and
ending on December 31 (“Contract Year 3”, “Contract Year 4”, etc.).

4.    Client Address Change. Client’s mailing address set forth in the preamble
and in Article 17 of the Amended and Restated Agreement is amended to read as
follows:

Adamas Pharmaceuticals, Inc.
1900 Powell Street, Suite 1000
Emeryville, CA 94608

5.    Other Terms. Except as expressly amended herein, all other terms and
conditions of the Amended and Restated Agreement will remain in full force and
effect. In the event of any conflict between this Amendment and the Amended and
Restated Agreement, the terms of this Amendment will control.

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IN WITNESS WHEREOF, the parties have caused their respective duly authorized
representatives to execute this Amendment effective as of the Amendment
Effective Date.
CATALENT PHARMA SOLUTIONS, LLC
 
ADAMAS PHARMA, LLC
 
 
 
 
 
 
 
By:
/s/Michael J. Valazza
 
By:
/s/Jennifer Rhodes
 
Name:
Michael J. Valazza
 
Name:
Jennifer Rhodes
 
Title:
Vice President, Business Development
 
Title:
General Counsel
 

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LIST OF AMENDED ATTACHMENTS

Attachment B: Specifications
I.
Client-supplied Materials (and associated specifications)

II.
Raw Materials (and associated specifications) and Qualified Vendor List

III.
Product Specifications (including Batch size)

    
Attachment C: Unit Pricing, Fees and Minimum Requirement

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ATTACHMENT B

SPECIFICATIONS

I.    Client-Supplied Materials (and associated specifications)

II.    Raw Materials (and associated specifications and approved vendor lists)

III.    Product Specifications

[*] (12 pages omitted)

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ATTACHMENT C

UNIT/BATCH PRICING, FEES, AND MINIMUM REQUIREMENT

[*] (6 pages omitted)