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Exhibit 10.95

AMENDMENT NO. 3 TO NOTE PURCHASE AGREEMENT

        This AMENDMENT NO. 3 is made as of the 11th day of July, 2002 (the
"Amendment") by and between Kevin Kimberlin Partners, L.P., a Delaware limited
partnership ("KKP"), The Immune Response Corporation, a Delaware corporation
("Seller"), Oshkim Limited Partnership ("Oshkim") and The Kimberlin Family 1998
Irrevocable Trust (the "Trust");

        WHEREAS, Seller, KKP and Oshkim entered into that certain Note Purchase
Agreement dated as of November 9, 2001, as amended by Amendment No. 1 to Note
Purchase Agreement dated as of February 14, 2002 and as further amended by
Amendment No. 2 to Note Purchase Agreement dated as of May 3, 2002 (the
"Agreement");

        WHEREAS, the Seller proposes to issue and sell Additional Securities to
the Trust and the Trust wishes to purchase Additional Securities from Seller.

        WHEREAS, the parties desire to amend the Agreement to add the Trust and
any affiliates of KKP, Oshkim and/or the Trust as parties and in certain other
respects as set forth below.

        NOW, THEREFORE, in consideration of the foregoing premises and the
mutual covenants set forth below, the parties hereby amend the Agreement and
agree as follows:

        1.    Effective as of the date of this Amendment, the Agreement is
hereby amended as follows:

        a.    The Trust and any affiliates of KKP, Oshkim and/or the Trust shall
be parties to the Agreement.

        b.    All references in the Agreement to "Buyer" for all purposes
related to Additional Securities shall be deemed to refer to the Trust and any
affiliates of KKP, Oshkim and/or the Trust.

        c.    Section 9 is hereby amended to add subsections (v) and (vi) which
shall read in their entirety as follows:

"(v) if Seller shall default in the payment of principal on any indebtedness (to
any party other than Buyer) in excess of $200,000 beyond the period of grace, if
any, provided in the instrument or agreement under which such indebtedness was
created,"

        2.    Except as specifically provided herein, the Agreement, as
originally executed by the parties thereto and as amended hereby, shall remain
in full force and effect.

        3.    Any defined terms not defined herein shall have the respective
meanings set forth in the Agreement.

        4.    This Amendment may be executed in counterparts, each of which
shall be deemed an original, but all of which together shall constitute one and
the same instrument.

        5.    This Amendment shall be governed by and construed in accordance
with the internal laws of the State of New York applicable to agreements made
and to be performed entirely within such jurisdiction.

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        IN WITNESS WHEREOF, the parties hereto have executed this Amendment as
of the date first above written.

 
 
KEVIN KIMBERLIN PARTNERS, L.P.
    
 
 
 
 
 
 
 
 
By:
 
 
 
         

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        Name:                

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        Title:                

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OSHKIM LIMITED PARTNERSHIP
    
 
 
 
 
 
 
 
 
By:
 
 
 
         

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        Name:                

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        Title:                

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THE KIMBERLIN FAMILY 1998 IRREVOCABLE TRUST
    
 
 
 
 
 
 
 
 
By:
 
 
 
         

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        Name:                

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        Title:                

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THE IMMUNE RESPONSE CORPORATION
    
 
 
 
 
 
 
 
 
By:
 
 
 
         

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        Name:                

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        Title:                

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Exhibit 10.95

AMENDMENT NO. 3 TO NOTE PURCHASE AGREEMENT