Exhibit 10.22

 

Laboratory Services and Confidentiality Agreement - Amendment 1*

Radius Health, Inc.

 

FIRST AMENDMENT TO LABORATORY SERVICES
AND CONFIDENTIALITY AGREEMENT

 

This is a First Amendment (“Amendment”) to Laboratory Services and
Confidentiality Agreement dated as of the 7th day of November, 2008 (the
“Effective Date”), amending the Laboratory Services and Confidentiality
Agreement (“Agreement”) dated March 31st, 2004 between Charles River
Laboratories, Inc. (“Laboratory”) and Radius Health, Inc. (formerly known as
Nuvios, Inc.) (“Sponsor”).  All undefined terms contained herein shall have the
meaning set forth in the Agreement.

 

WHEREAS, Sponsor and Laboratory wish to amend the Agreement as hereafter
provided.

 

NOW, THEREFORE, for good and valuable consideration and intending to be legally
bound, the parties hereby agree as follows:

 

1.                                       The Services may be performed by
Laboratory or any of its affiliates at any of the facilities listed on Exhibit A
attached hereto and made a part hereof.

 

2.                                       Notices from Sponsor to Laboratory
shall be addressed to the applicable facility at the address listed on
Exhibit A, with copies as indicated on Exhibit A.

 

3.                                       Notices from Laboratory to Sponsor
shall be addressed to:

 

“Radius Health, Inc.
300 Technology Square
Cambridge, MA 02139
Attn: Chief Financial Officer”

 

4.                                       The Agreement between Laboratory and
Sponsor is hereby amended to extend the term until March 31st, 2014.

 

5.                                       All Services shall be performed in
accordance with the Supporting Documents applicable to the Services and shall be
performed in accordance with the applicable laws and regulations of said
jurisdiction.

 

6.                                       Section 11.2 of the Agreement will be
replaced in its entirety with the following:

 

“Laboratory’s liability under this Agreement, regardless of the form of action,
shall not exceed [*] provided under the Letter of Payment Authorization under
which such liability arises.

 

7.                                       Section 19.3 of the Agreement will be
replaced in its entirety with the following:

 

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* Confidential Treatment Requested by the Registrant.  Redacted Portion Filed
Separately with the Commission.

 

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“This Agreement, and the rights and obligations hereunder, may not be assigned
or transferred by Laboratory without the prior written consent of Sponsor.
However, Laboratory may, without the consent of Sponsor, transfer or assign this
Agreement, in whole or in part to an affiliate, or in connection with a merger,
consolidation, or a sale or transfer of all or substantially all of the assets
to which this Agreement relates, provided that Laboratory notifies Sponsor [*]
([*]) days prior to such merger, consolidation, sale or transfer, and provided
that all obligations of Laboratory are assumed by the assignee. Sponsor may
assign this Agreement in whole or in part without consent of Laboratory. No
assignment will relieve either party of the performance of any accrued
obligation that such party may then have under this Agreement.”

 

8.                                       All other terms and conditions of the
Agreement, as amended and modified, are hereby ratified, confirmed and approved.

 

IN WITNESS WHEREOF, duly authorized representatives of the parties have signed
this Amendment as of the Effective Date.

 

Charles River Laboratories, Inc.

 

Sponsor

 

 

 

 

 

 

By:

/s/ Chris Perkin

 

By:

/s/ B.N. Harvey

 

duly authorized

 

 

duly authorized

 

 

 

For Print Name: Chris Perkin, D.A.B.T.

 

Print Name: B.N. Harvey

Title:

Corporate Senior Vice President & President,

 

Title: CFO

 

Canadian & Chinese Preclinical Services

 

 

Date:

November 12, 2008

 

Date: 11/12/08

 

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* Confidential Treatment Requested by the Registrant.  Redacted Portion Filed
Separately with the Commission.

 

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Exhibit A

 

Work may be conducted at any of the following Charles River Laboratories
locations:

 

[*]

 

[*]

[*]

 

[*]

[*]

 

[*]

[*]

 

[*]

[*]

 

[*]

[*]

 

[*]

[*]

 

[*]

[*]

 

[*]

[*]

 

[*]

 

A COPY OF ALL NOTICES SHALL BE SENT TO:

 

Charles River Laboratories, Inc.

251 Ballardvale Street

Wilmington, MA 01887

Attn: General Counsel

Tel (978) 658-6000

Fax: (978) 658-988-5665

 

Charles River Laboratories, Inc.

251 Ballardvale Street

Wilmington MA 01887

Attn:                    Heidi Oskar, Senior Contracts Administrator

Tel (978) 658-6000

Fax: (978) 988-5827

 

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* Confidential Treatment Requested by the Registrant.  Redacted Portion Filed
Separately with the Commission.

 

3

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