Exhibit 10.22

Innovation and
Northwestern University
Phone 847-467-2097
Northwestern |INVO
New Ventures Office
1800 Sherman Ave, Suite 504
invo.northwestern.edu
Innovation and New Ventures
 
Evanston, IL 60201
 
 

     November 30, 2017

David A Giljohann, Ph.D.
Chief Executive Officer
Exicure, Inc.
8045 Lamon Ave.
Skokie, IL 60077

Re:    Amendment Two to the Amended Restated License Agreement effective
December 12, 2011 between Exicure, Inc. ("Exicure") and Northwestern University
("Northwestern') (the "Agreement").

Dear David:

This letter agreement memorializes the understanding reached between
Northwestern and Exicure regarding the Second Amendment to the Agreement
("Amendment Two). Unless otherwise defined In this Amendment Two, capitalized
terms shall have the meaning assigned to them in the Agreement.

Subject to the terms and conditions of the Agreement and Exicure's compliance
therewith, the parties hereby agree as follows:

1.
Appendix A of the Agreement is amended and incorporated herein by reference.

2.
All other terms and conditions of the Agreement shall remain in full force and
effect as amended hereby.

By signing below, the parties hereby execute this valid and binding agreement
effective as of the date listed above.

NORTHWESTERN UNIVERSITY
 
EXICURE, INC.
/s/ Alicia Löffler, Ph.D.
 
/s/ David A. Giljohann, Ph.D.
Alicia Löffler, Ph.D.
 
David A. Giljohann, Ph.D.
Associate Vice President for Research
 
Chief Executive Officer
and Executive Director, INVO
 
 

THE COMPANY HAS REQUESTED AN ORDER FROM THE SECURITIES AND EXCHANGE COMMISSION
(THE “COMMISSION”) PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, GRANTING CONFIDENTIAL TREATMENT TO SELECTED PORTIONS. ACCORDINGLY, THE
CONFIDENTIAL PORTIONS HAVE BEEN OMITTED FROM THIS EXHIBIT, AND HAVE BEEN FILED
SEPARATELY WITH THE COMMISSION. OMITTED PORTIONS ARE INDICATED IN THIS EXHIBIT
WITH “*****”.

--------------------------------------------------------------------------------

Innovation and
Northwestern University
Phone 847-467-2097
Northwestern |INVO
New Ventures Office
1800 Sherman Ave, Suite 504
invo.northwestern.edu
Innovation and New Ventures
 
Evanston, IL 60201
 
 

Exhibit A:

NU ID
Filing Date
Application Number
Patent Number
Type
Country
Status
Title
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THE COMPANY HAS REQUESTED AN ORDER FROM THE SECURITIES AND EXCHANGE COMMISSION
(THE “COMMISSION”) PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, GRANTING CONFIDENTIAL TREATMENT TO SELECTED PORTIONS. ACCORDINGLY, THE
CONFIDENTIAL PORTIONS HAVE BEEN OMITTED FROM THIS EXHIBIT, AND HAVE BEEN FILED
SEPARATELY WITH THE COMMISSION. OMITTED PORTIONS ARE INDICATED IN THIS EXHIBIT
WITH “*****”.

--------------------------------------------------------------------------------

Innovation and
Northwestern University
Phone 847-467-2097
Northwestern |INVO
New Ventures Office
1800 Sherman Ave, Suite 504
invo.northwestern.edu
Innovation and New Ventures
 
Evanston, IL 60201
 
 

NU ID
Filing Date
Application Number
Patent Number
Type
Country
Status
Title
*****
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THE COMPANY HAS REQUESTED AN ORDER FROM THE SECURITIES AND EXCHANGE COMMISSION
(THE “COMMISSION”) PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, GRANTING CONFIDENTIAL TREATMENT TO SELECTED PORTIONS. ACCORDINGLY, THE
CONFIDENTIAL PORTIONS HAVE BEEN OMITTED FROM THIS EXHIBIT, AND HAVE BEEN FILED
SEPARATELY WITH THE COMMISSION. OMITTED PORTIONS ARE INDICATED IN THIS EXHIBIT
WITH “*****”.

--------------------------------------------------------------------------------

Innovation and
Northwestern University
Phone 847-467-2097
Northwestern |INVO
New Ventures Office
1800 Sherman Ave, Suite 504
invo.northwestern.edu
Innovation and New Ventures
 
Evanston, IL 60201
 
 

NU ID
Filing Date
Application Number
Patent Number
Type
Country
Status
Title
*****
*****
*****
 
*****
*****
*****
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THE COMPANY HAS REQUESTED AN ORDER FROM THE SECURITIES AND EXCHANGE COMMISSION
(THE “COMMISSION”) PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, GRANTING CONFIDENTIAL TREATMENT TO SELECTED PORTIONS. ACCORDINGLY, THE
CONFIDENTIAL PORTIONS HAVE BEEN OMITTED FROM THIS EXHIBIT, AND HAVE BEEN FILED
SEPARATELY WITH THE COMMISSION. OMITTED PORTIONS ARE INDICATED IN THIS EXHIBIT
WITH “*****”.

--------------------------------------------------------------------------------

Innovation and
Northwestern University
Phone 847-467-2097
Northwestern |INVO
New Ventures Office
1800 Sherman Ave, Suite 504
invo.northwestern.edu
Innovation and New Ventures
 
Evanston, IL 60201
 
 

NU ID
Filing Date
Application Number
Patent Number
Type
Country
Status
Title
*****
*****
*****
 
*****
*****
*****
*****
*****
*****
*****
 
*****
*****
*****
*****
*****
*****
*****
*****
*****
*****
*****
*****
*****
*****
*****
 
*****
*****
*****
*****

THE COMPANY HAS REQUESTED AN ORDER FROM THE SECURITIES AND EXCHANGE COMMISSION
(THE “COMMISSION”) PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, GRANTING CONFIDENTIAL TREATMENT TO SELECTED PORTIONS. ACCORDINGLY, THE
CONFIDENTIAL PORTIONS HAVE BEEN OMITTED FROM THIS EXHIBIT, AND HAVE BEEN FILED
SEPARATELY WITH THE COMMISSION. OMITTED PORTIONS ARE INDICATED IN THIS EXHIBIT
WITH “*****”.