Exhibit 10.10

TRADEMARK SECURITY AGREEMENT

TRADEMARK SECURITY AGREEMENT, dated as of December 15, 2004, by TGC Research
Limited (a company incorporated in England and Wales with registered number
05273708, “Grantor”), in favor of BCC Acquisition II LLC (“Bay City”), in its
capacity as agent (“Agent”) for itself and Gerald L. Cohn Revocable Trust (“Cohn
Trust”), Hannah S. and Samuel A. Cohn Memorial Foundation (“Cohn Foundation”),
and AEOW 96, LLC (“AEOW”). Bay City, Cohn Trust, Cohn Foundation and AEOW are
collectively referred to herein as the “Note Holders”.

W I T N E S S E T H:

WHEREAS, Bay City, Cohn Trust, Cohn Foundation and AEOW are parties to that
certain Note Purchase Agreement, dated as of August 4, 1998, as amended by that
certain First Amendment to Note Purchase Agreement, dated as of April 7, 2003
and further amended by that certain Second Amendment and Limited Waiver to Note
Purchase Agreement, dated as of August 13, 2004 (as further amended, restated,
supplemented and otherwise modified from time to time, the “Note Purchase
Agreement”); and

WHEREAS, Grantor purchased certain assets formerly held by Diametrics Medical,
Ltd. and, in consideration for the Note Holders consenting to the liquidation of
Diametrics Medical, Ltd. and the sale of its assets, Grantor has agreed to enter
into a General Security Agreement (“General Security Agreement”) and this
Trademark Security Agreement;

NOW, THEREFORE, in consideration of the premises and mutual covenants herein
contained and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, Grantor hereby agrees as follows:

1. GRANT OF SECURITY INTEREST IN TRADEMARK COLLATERAL. Subject to the rights of
those certain Beneficiaries identified in that certain Debenture between Barbara
R. Mittman as agent, dated as of December 15, 2004, to a first priority security
interest in all assets of Grantor, Grantor hereby grants to Agent, on behalf of
itself and the Note Holders, a continuing security interest in all of Grantor’s
right, title and interest in, to and under the following, whether presently
existing or hereafter created or acquired (collectively, the “Trademark
Collateral”):

(a) all of its trademarks, trade names, trade styles, corporate names, business
names, service marks, logos, internet domain names, other source of business
identifiers, prints and labels on which any of the foregoing have appeared or
appear, and trademark and service mark applications (“Trademarks”) and all
licenses and rights to use any of the Trademarks (“Trademark Licenses”) to which
it is a party including those referred to on Schedule 1 hereto;

(b) all reissues, continuations or extensions of the foregoing;

(c) all goodwill of the business connected with the use of, and symbolized by,
each Trademark and each Trademark License; and

(d) all products and proceeds of the foregoing, including, without limitation,
any claim by Grantor against third parties for past, present or future (i)
infringement or dilution of any Trademark or Trademark licensed under any
Trademark License or (ii) injury to the goodwill associated with any Trademark
or any Trademark licensed under any Trademark License.

2. SECURITY AGREEMENT. The security interests granted pursuant to this Trademark
Security Agreement are granted in conjunction with the security interests
granted to Agent, on behalf of itself and the Note Holders, pursuant to the
General Security Agreement. Grantor hereby acknowledges and affirms that the
rights and remedies of Agent with respect to the security interest in the
Trademark Collateral made and granted hereby are more fully set forth in the
General Security Agreement, the terms and provisions of which are incorporated
by reference herein as if fully set forth herein.

[signature page follows]

1

IN WITNESS WHEREOF, the parties hereto have caused this Trademark Security
Agreement to be executed as of the date and year first written above.

GRANTOR

TGC RESEARCH LIMITED

By: /s/ David B. Kaysen

      Name: David B. Kaysen

Title: Director

THE SECURED PARTY

BCC ACQUISITION II LLC, as agent

     
By:
Its:
  THE BAY CITY CAPITAL FUND I, L.P.
Manager
 
   
By:
Its:
  Bay City Capital Management LLC
General Partner
 
   
By:
Its:
  /s/ Fred Craves
Managing Director
 
   

2

SCHEDULE 1

to

TRADEMARK SECURITY AGREEMENT

TRADEMARK REGISTRATIONS

         
MarkReg.
  No.   Date
 
       
Neurotrend
Neotrend
Paratrend 7
  2,232,933. S/N 75-323,109
2,232,863, S/N 75-294,924
1,792,144, S/N 74-128,356  

 
       
Expired Trademarks
 
 

 
       
CAL-POD
CARDIOMET
  1,504,639, S/N 73-676,237
1,537,310, S/N 73-667,464  

 
       

3