Exhibit 10.6

LICENSE AGREEMENT

THIS LICENSE AGREEMENT (the “Agreement”) effective as of March 25, 1999 (the
“Effective Date”) is by and between Genzyme Corporation, a Massachusetts
corporation having its principal offices at One Kendall Square, Cambridge, MA
02139 (“Genzyme”), through Genzyme’s Molecular Oncology Division, and EXACT
Laboratories, Inc., a Delaware corporation having its principal offices at 63
Great Road, Maynard, MA 01754 (“EXACT”).

WITNESSETH:

WHEREAS, Genzyme is the licensee of certain patent rights relating to the Field
(as defined herein) under the JHU License Agreement (as defined herein) and is
willing to grant to EXACT a worldwide, nonexclusive, royalty-bearing sublicense
to use such patent rights for the development and commercialization of
Diagnostic Services, Licensed Reagents and Kits (each as defined herein) in the
Field upon the terms and conditions set forth herein; and

WHEREAS, EXACT desires to obtain a worldwide, nonexclusive, royalty-bearing
sublicense to use such patent rights for the development and commercialization
of Diagnostic Services, Licensed Reagents and Kits in the Field on the terms and
conditions set forth herein; and

WHEREAS, Genzyme is willing to grant EXACT such a sublicense on the terms and
conditions set forth herein in light of the relationship between EXACT and JHU
(as defined herein) and the relationship between Genzyme and JHU;

NOW THEREFORE, in consideration of the mutual covenants herein contained and
intending to be legally bound hereby, the parties hereto agree as follows:

ARTICLE 1.  DEFINITIONS

1.1                                 “Affiliate” shall mean any corporation or
other entity which controls, is controlled by, or is under common control with
EXACT.  A corporation or other entity shall be regarded as in control of another
corporation or entity if it owns or directly or indirectly controls more than
fifty percent (50%) of the voting stock or other ownership interest of the other
corporation or entity, or if it possesses, directly or indirectly, the power to
direct or cause the direction of the management and policies of the corporation
or other entity or the power to elect or appoint more than fifty percent (50%)
of the members of the governing body of the corporation or other entity.

1.2                                 “Diagnostic Service(s)” shall mean the
performance of laboratory-based assays covered in whole or in part by a Valid
Claim of the Patent Rights.

1.3                                 “Field” shall mean the determination, in
stool or samples prepared from stool, of the presence of, absence of or
variation(s) within a nucleic acid of interest, or differences between a nucleic
acid of interest and a reference standard or sample, including but not limited
to screening, diagnosis, prognosis and monitoring tests, for the purpose of
detecting changes associated with colorectal cancer.

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1.4                                 “First Commercial Sale” shall mean (a) the
first performance for consideration of a Diagnostic Service in the Field or (b)
the first sale for consideration of a Licensed Reagent or Kit for use in the
Field, as applicable.  Any performance of a Diagnostic Service or transfer of
Licensed Reagents or Kits by EXACT solely for purposes of performing Research
shall not be deemed to constitute a First Commercial Sale.

1.5                                 “Gene Patent Rights” shall mean the United
States and foreign patents and patent applications relating to the APC gene
and/or the p53 gene and licensed (with the right to grant sublicenses) to
Genzyme pursuant to the JHU License Agreement together with patents arising
therefrom and any extensions, registrations, confirmations, reissues, divisions,
continuations or continuations-in-part, re-examinations or renewals thereof,
including without limitation the patents and patent applications listed in
Appendix A hereto (which may be updated from time to time to include such
additional patents and patent application that may arise therefrom); provided,
however, that Gene Patent Rights expressly excludes any claims of such patents
and patent applications that fall outside of the Field, including, without
limitation, claims to antibodies, to the treatment, prevention or remedying of a
gene deficiency, to purified proteins, or to DNA sequences other than those
sequences that correspond to the p53 gene and the APC gene; provided further
that DNA sequences which are (i) immediately adjacent to the p53 or APC genes
and (ii) necessary to the use of the p53 or APC genes, respectively, in the
Field shall be considered within the Gene Patent Rights.

1.6                                 “Instrument” shall mean any instrument,
apparatus, appliance, automated system or computer software that is covered in
whole or in part by a Valid Claim of the Patent Rights and is useful or
necessary for performing laboratory-based assays.

1.7                                 “JHU License Agreement” shall mean the
License Agreement dated as of February 5, 1992 by and between Genzyme (as
successor to PharmaGenics, Inc.), The Johns Hopkins University (“JHU”) and
Hoffman-La Roche Inc.  (“Roche”), as amended from time to time.

1.8                                 “Kit” shall mean a collection of one or more
Reagents, including at least one Licensed Reagent, packaged in the form of a
kit.

1.9                                 “Licensed Reagent” shall mean any Reagent
covered in whole or in part by a Valid Claim of the Patent Rights.

1.10                           “Methodology Patent Rights” shall mean the United
States and foreign patents and patent applications relating to methods of
detecting mammalian nucleic acids isolated from stool specimens and reagents
therefor and licensed (with the right to grant sublicenses) to Genzyme pursuant
to the JHU License Agreement together with patents resulting therefrom and any
extensions, registrations, confirmations, reissues, divisions, continuations or
continuations-in-part, re-examinations or renewals thereof, including without
limitation the patents and patent application listed in Appendix B hereto (which
may be updated from time to time to include such additional patents and patent
applications that may arise therefrom).

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1.11                           (a)           “Net Sales” shall mean the adjusted
gross sales of Licensed Reagents and Kits by EXACT less eight percent (8%) of
adjusted gross sales in lieu of items such as custom duties, inbound
transportation, insurance costs, agent’s commission, bad debts, etc.  The
adjusted gross sales shall mean the actual gross sales price of a Licensed
Reagent or Kit billed by EXACT (not including miscellaneous items on the invoice
such as taxes, etc.) less chargebacks, cash discounts, credits or allowances
(not including miscellaneous items credited such as taxes, etc.) including those
incurred or granted on account of price adjustments, rejections, returns,
rebates or recalls of Licensed Reagents or Kits previously sold.  “Net Sales”
does not include “no charge” samples to the extent customary in the trade.

(b)           In the event that EXACT decides to sell a Kit which combines
Licensed Reagents with ingredients or components which are not Licensed Reagents
(such other ingredients or components being “Other Items”), then (i) EXACT shall
notify Genzyme in writing of its intent to offer such combination, (ii) Genzyme
and EXACT shall, within thirty (30) days after Genzyme’s receipt of such
notification, initiate good-faith negotiations on the value of the Licensed
Reagents which shall be used as the basis to calculate Net Sales pursuant to
this clause (b) and (iii) if the parties can not reach agreement within thirty
(30) days after the commencement of such negotiations, such dispute shall be
referred to arbitration pursuant to Article 11 hereof.  However, in no event
shall the royalty rates on Net Sales be reduced by more than fifty percent
(50%).  The term “Other Items” does not include solvents, diluents, carriers,
excipients, enzymes used in amplification for diagnostic use, or the like used
in formulating a product.

(c)           In the event that a Licensed Reagent or Kit is sold for
non-monetary consideration in addition to or in lieu of money, the value of such
consideration to the extent that it can be reasonably determined by EXACT shall
be added to Net Sales in accordance with Sections 1.11 (a) and (b) hereof.

(d)           No deductions shall be made for commissions paid to individuals
whether they be with independent sales agencies or regularly employed by EXACT
and on its payroll, or for cost of collections.

(e)           Net Sales expressly excludes transfers or dispositions of Licensed
Reagents or Kits at cost or less than cost for the sole purpose of conducting
Research.

1.12                           (a)           “Net Service Revenues” shall mean
actual billings by EXACT for the performance of Diagnostic Services less the
following deductions to the extent that they are applicable and are not already
deducted in the actual billings: (i) discounts allowed and taken, in amounts
customary in the trade; (ii) sales and/or use taxes and/or duties imposed upon
and with specific reference to particular sales.

(b)             If a Diagnostic Service(s) is offered in combination with
another diagnostic or other service(s) (such as patient counseling) provided by
EXACT (such other services being referred to as “Other Services” and such
Diagnostic Service(s) and Other Services collectively being referred to as
“Combination Services”), Net Service Revenues for

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purposes of determining royalties on the Diagnostic Service(s) shall be
calculated as provided below:

(i)                                     If the Diagnostic Service(s) and the
Other Services are sold or provided separately, Net Service Revenues shall be
calculated by multiplying the Net Service Revenues of the Combination Service
(as determined in accordance with Section 1.12(a) above but applied to the
Combination Service), by the fraction A/(A+B), where “A” is the invoice price of
the Diagnostic Service(s) and “B” is the invoice price of the Other Services in
the Combination Service if sold or provided separately.

(ii)                                  If the Diagnostic Service(s) are sold or
provided separately but the Other Services are not, Net Service Revenues shall
be calculated by multiplying the Net Service Revenues of the Combination Service
(as determined in accordance with Section 1.12(a) above but applied to the
Combination Service), by the fraction A/C, where “A” is the invoice price of the
Diagnostic Service(s) and “C” is the invoice price of the Combination Service.

(iii)                               If the Diagnostic Service(s) and the Other
Services in the combination are not sold or provided separately, Net Service
Revenues for purpose of determining royalties on the Diagnostic Service(s) shall
be calculated by multiplying Net Service Revenues of the Combination Service (as
determined in accordance with Section 1.12(a) above but applied to the
Combination Service) by the fraction E/(E+D), where “E” is the value of the
Diagnostic Service(s) and “D” is the reasonably estimated value (using accepted
diagnostic industry standards) of the Other Services based at least in part on
the value of the other active component or components used in the Combination
Service; provided, that (A) EXACT shall notify Genzyme in writing of its intent
to offer such Combination Services, (B) Genzyme and EXACT shall, within thirty
(30) days after Genzyme’s receipt of such notification, initiate good-faith
negotiations on the value of the Diagnostic Service(s) and Other Services which
shall be used as the basis to calculate Net Service Revenues pursuant to this
clause (iii) and (C) if the parties can not reach agreement within thirty (30)
days after the commencement of such negotiations, such dispute shall be referred
to arbitration pursuant to Article 11 hereof.

(c)           In the event that a Diagnostic Service is provided for
non-monetary consideration in addition to or in lieu of money, the value of such
non-monetary consideration to the extent that it can be reasonably determined by
EXACT shall be added to Net Service Revenues in accordance with Sections 1.12(a)
and (b) hereof.

(d)           Net Service Revenues expressly excludes the use or performance of
Diagnostic Services at cost or less than cost for the sole purpose of conducting
Research.

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1.13                           “Patent Rights” shall mean collectively the Gene
Patent Rights and the Methodology Patent Rights.

1.14                           “Reagents” shall mean reagents useful in or
necessary to the performance of laboratory-based assays, whether used
individually or sold or used as one or more component(s) of a kit.

1.15                           “Research” shall mean pre-clinical, clinical and
regulatory activities conducted by or on behalf of EXACT to develop and obtain
regulatory approvals of products or services utilizing the Patent Rights
licensed to EXACT hereunder.

1.16                           “Valid Claim” shall mean an issued claim of an
unexpired patent, or a claim of a pending patent application, which shall not
have been withdrawn, canceled or disclaimed, or held invalid or unenforceable by
a court of competent jurisdiction in an unappealed or unappealable decision. 
Notwithstanding the foregoing to the contrary, a claim of a pending patent
application, divisional application, or continuation-in-part application, or the
foreign equivalents thereof, shall cease to be a Valid Claim if no patent has
issued on such claim on or prior to the fifth (5th) anniversary of the date of
filing such patent application (or, in the case of a continuation application or
foreign equivalent thereof, the date of filing of the earliest parent
application), provided that such claim shall once again become a Valid Claim on
the issue date of a patent that subsequently issues and includes such claim.

ARTICLE 2.  LICENSE GRANT

2.1                                 Genzyme hereby grants to EXACT, subject to
all the terms and conditions of this Agreement, a worldwide, nonexclusive right
and license (without the right to grant sublicenses) under the Patent Rights to:
(a) use, offer to sell, sell and practice Diagnostic Services in the Field; (b)
make, have made, use, offer to sell, sell and import Licensed Reagents in the
Field; and (c) make, have made, use, offer to sell, sell and import Kits in the
Field.

2.2                                 The license granted hereunder shall not
extend to Instruments.  In the event that Genzyme becomes aware of any
Instruments, Genzyme shall deliver written notice thereof to EXACT.  In the
event that after the Effective Date EXACT decides in good faith to develop
Instruments for use in the Field and delivers written notice of such decision to
Genzyme, Genzyme and EXACT shall, within thirty (30) days after Genzyme’s
receipt of such notification from EXACT, enter into good faith negotiations for
a worldwide, non-exclusive license (without the right to grant sublicenses) to
be granted by Genzyme to EXACT under the Patent Rights to make, use, offer to
sell, sell and import Instruments in the Field.  Any such license shall include
commercially reasonable terms and conditions.  In the event that Genzyme and
EXACT are unable to reach agreement on the terms of any such license within
ninety (90) days after the date Genzyme and EXACT commence negotiations for such
license, then the dispute shall be immediately referred to one (1) executive
officer of each party, chosen at the sole discretion of that party, who shall
negotiate in good faith with each other to resolve the dispute during the period
ending thirty (30) days after the date of such referral.  If the designated
officers of the parties are

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unable to resolve the dispute within such thirty (30) day period, the dispute
shall be referred to arbitration pursuant to Article 11 hereof.

ARTICLE 3.  DUE DILIGENCE

3.1                                 EXACT agrees to use commercially reasonable
efforts to make (i) Diagnostic Services,(ii) Licensed Reagents and (iii) Kits
available for the benefit of the general public consistent with regulatory
compliance and public safety.

3.2                                 EXACT’s material failure to perform in
accordance with any subsection of Section 3.1 above shall be grounds for Genzyme
to terminate the license under Section 2.1.  above with respect to Diagnostic
Services, Licensed Reagents or Kits, as applicable, pursuant to Section 7.8
hereof by delivering written notice of its intention to terminate to EXACT.  If
EXACT disputes Genzyme’s determination, (i) EXACT shall deliver written notice
of such dispute within ten (10) business days after its receipt of notice from
Genzyme of its intent to terminate, (ii) the matter shall be referred to
arbitration pursuant to Article 11hereof and (iii) EXACT’s license under Section
2.1 above to the Diagnostic Services, Licensed Reagents or Kits, as applicable,
and EXACT’s obligations with respect thereto shall continue in full force and
effect until the resolution of such arbitration.

3.3                                 Within thirty (30) days after the date this
Agreement is signed on behalf of EXACT and subsequently no later than May 1 and
November 1 of each year, commencing on November 1, 1999, EXACT shall provide a
written report to Genzyme on its research, development and commercialization
efforts with respect to (i) Diagnostic Services, (ii)Licensed Reagents and (iii)
Kits (each individually), which report shall cite specific goals and objectives
in researching, developing and commercializing the licensed technology and
methodology and progress in meeting these goals and objectives.  If Genzyme does
not receive any such report(s) in a timely manner, it shall notify EXACT of such
delinquency in writing.  EXACT shall have thirty (30) days from its receipt of
such notice to provide Genzyme with any and all overdue report(s).  Failure by
EXACT to provide such overdue report(s) within said thirty (30) day period may
constitute grounds for termination of this Agreement by Genzyme as provided for
in Section 7.5 hereof; provided, however, that the number of days elapsed since
EXACT first received notice from Genzyme of the delinquent reports shall be
counted for purposes of determining the sixty (60) day period described in
Section 7.5 hereof.

ARTICLE 4.  PAYMENTS

4.1                                 In partial consideration for the license
granted hereunder, and upon execution of this Agreement, EXACT agrees to pay
Genzyme one hundred and fifty thousand dollars($150,000), which amount shall not
be creditable against any other amounts payable by EXACT to Genzyme hereunder.

4.2                                 EXACT shall pay to Genzyme during the term
of this Agreement a royalty amounting to(a) three percent (3%) of Net Service
Revenues worldwide and (b) three percent (3%) of Net Sales worldwide.

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4.3                                 (a) EXACT shall pay Genzyme a minimum
royalty of twenty thousand dollars($20,000) per year payable within thirty (30)
days of the date this Agreement is signed on behalf of EXACT for 1999 and on
January 1 of each year thereafter with respect to the licenses granted for
Diagnostic Services; provided, however, that the minimum royalty for a given
year shall be creditable against any royalties subsequently due during said year
under Section 4.2.

(b)           EXACT shall pay Genzyme a minimum royalty of twenty thousand
dollars($20,000) per year payable on January 1, 2004 and on January 1 of each
year thereafter with respect to the licenses granted for Licensed Reagents and
Kits; provided, however, that the minimum royalty for a given year shall be
creditable against any royalties subsequently due during said year under Section
4.2.

(c)           Waiver or deferral of any minimum royalty payment by Genzyme shall
not be construed as waiver or deferral of any such subsequent payment.

4.4                                 (a)           In the event that the First
Commercial Sale of a Diagnostic Service by EXACT has not occurred within five
(5) years after the Effective Date, EXACT shall pay Genzyme an annual
maintenance fee of one hundred thousand dollars ($100,000) payable on each
anniversary of the Effective Date commencing with the fifth (5th) anniversary of
the Effective Date; provided, however, that if EXACT has submitted a bona fide
application to the U.S.  Food and Drug Administration or the equivalent
authority at that time (“FDA”) to obtain final marketing approval for a
Diagnostic Service within said five(5) year period and EXACT’s failure to make
such First Commercial Sale is due to delays in obtaining such approval that are
caused by the FDA and are not related to a substantial deficit in said
application, then Genzyme may elect, in its sole discretion, to extend said five
(5) year period and shall notify EXACT in writing of any such determination and
election and of the amount of time by which such period has been extended;
provided further that if the parties disagree as to whether said application
contained a substantial deficit and the time for resolution of such deficit, the
dispute shall be referred to arbitration pursuant to Article 11 hereof and,
until final resolution of the dispute, EXACT shall deposit any amounts otherwise
due and payable to Genzyme under this Section4.4(a) into an escrow account
established by EXACT exclusively for such purpose in a recognized commercial
banking institution reasonably selected by EXACT and promptly identified by
written notice from EXACT to Genzyme.  If the arbitrator resolves the dispute in
favor of Genzyme, then the amounts held in escrow plus all interest accrued
thereon shall be promptly paid to Genzyme in same day funds.  Amount payable
under this Section 4.4(a) shall not be creditable against any royalties or other
payments due during said year under this Article 4.  Waiver or deferral of any
maintenance fee by Genzyme shall not be construed as waiver or deferral of any
such subsequent payment.

(b)           In the event that the First Commercial Sale of a Kit by EXACT has
not occurred within seven (7) years after the Effective Date and the license
granted pursuant to Section 2.1 (c) hereof has not been terminated by Genzyme
pursuant to Section 7.7 hereof, EXACT shall pay Genzyme an annual maintenance
fee of one hundred thousand dollars ($100,000) payable on each anniversary of
the Effective Date commencing with the

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seventh (7th) anniversary of the Effective Date; provided, however, that if
EXACT has submitted a bona fide application to the FDA to obtain final marketing
approval for a Kit within said seven (7) year period and EXACT’s failure to make
such First Commercial Sale is due to delays in obtaining such approval that are
caused by the FDA and are not related to a substantial deficit in said
application, then Genzyme may elect, in its sole discretion, to extend said
seven (7) year period and shall notify EXACT in writing of any such
determination and election and of the amount of time by which such period has
been extended; provided further that if the parties disagree as to whether said
application contained a substantial deficit and the time for resolution of such
deficit, the dispute shall be referred to arbitration pursuant to Article 11
hereof and, until final resolution of the dispute, EXACT shall deposit any
amounts otherwise due and payable to Genzyme under this Section 4.4(b) into an
escrow account established by EXACT exclusively for such purpose in a recognized
commercial banking institution reasonably selected by EXACT and promptly
identified by written notice from EXACT to Genzyme.  If the arbitrator resolves
the dispute in favor of Genzyme, then the amounts held in escrow plus all
interest accrued thereon shall be promptly paid to Genzyme in same day funds. 
Amount payable under this Section 4.4(b) shall not be creditable against any
royalties or other payments due during said year under this Article 4.  Waiver
or deferral of any maintenance fee by Genzyme shall not be construed as waiver
or deferral of any such subsequent payment.

4.5                                 EXACT shall pay Genzyme a milestone payment
in the amount of two hundred and fifty thousand dollars ($250,000) within thirty
(30) days after the first receipt by EXACT of either 510(k) clearance or
approval of a Pre-Marketing Authorization application(“PMA”) (or the equivalent
of such submissions required at such time) for a Kit from the FDA.  Such amount
shall not be creditable against any royalties or other payments due under this
Article 4.

4.6                                 Payment of royalties specified in Section
4.2 shall be made by EXACT to Genzyme within forty-five (45) days after March
31, June 30, September 30 and December 31 each year during the term of this
Agreement covering Net Sales and Net Service Revenues during the preceding
calendar quarter.  The last such payment shall be made within forty-five (45)
days after the expiration or earlier termination of this Agreement.

4.7                                 No multiple royalties shall be payable on
any Diagnostic Service, Licensed Reagent or Kit because such Diagnostic Service,
Licensed Reagent or Kit or its practice, manufacture, use, importation or sale
is or shall be covered by more than one of the Patent Rights.

4.8                                 All payments to be made under this Article 4
shall be paid in United States dollars, in Boston, Massachusetts or at such
other place and in such other way as Genzyme may reasonably designate in
writing, without deduction of exchange, collection or other charges.  Conversion
of foreign currency into United States dollars shall be calculated using the
applicable exchange rate as published in The Wall Street Journal on the date
that the payment is first due and payable.  If by law, regulation or fiscal
policy of a particular country, conversion into United States dollars or
transfers of funds of a convertible currency to the Untied States is restricted
or forbidden, EXACT shall give

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Genzyme prompt written notice of such restriction or prohibition, which notice
shall satisfy the forty-five (45) day payment deadline set forth in Section
4.6.  EXACT shall pay any amounts due to Genzyme through whatever lawful methods
Genzyme reasonably designates in writing; provided, however, that if Genzyme
fails to designate such payment method within thirty (30) days after Genzyme is
notified of the restriction, EXACT may deposit such payment in local currency to
the credit of Genzyme in a recognized commercial banking institution reasonably
selected by EXACT and promptly identified by written notice from EXACT to
Genzyme, and such deposit shall fulfill all obligations of EXACT to Genzyme with
respect to such payment.

4.9                                 In the event that any payment due hereunder
is not made when due, the payment shall accrue interest beginning on the first
day following the due date as herein specified, calculated at the annual rate of
the sum of (a) two percent (2%) plus (b) the prime interest rate quoted by
BankBoston N.A.  on the date said payment is due, the interest being compounded
on the last day of each calendar quarter; provided, that in no event shall said
annual rate exceed the maximum legal interest rate in Massachusetts.  The
payment of such interest shall not foreclose Genzyme from exercising any other
rights it may have as a consequence of the lateness of any payment.

4.10                           Royalty payments and other payments due to
Genzyme under this Agreement shall not be reduced by reason of any withholding
or similar taxes applicable to such payments to Genzyme.

4.11                           Genzyme hereby agrees that if, after the
Effective Date, (a) Genzyme grants a license(“Subsequent Comparable License”) to
another person or entity (other than a wholly-owned subsidiary of Genzyme)
conveying rights to (i) practice Diagnostic Services in the Field, (ii) make,
use, offer to sell, sell and import Licensed Reagents for use in the Field, or
(iii) make, use, offer to sell, sell and import Kits for use in the Field, (b)
such person or entity intends to sell Diagnostic Services, Licensed Reagents or
Kits, as applicable, other than for research purposes and (c) such Subsequent
Comparable License has financial terms which, taken as a whole, are more
favorable to such person or entity than those set forth herein, Genzyme shall
promptly deliver written notice to EXACT of the grant of such Subsequent
Comparable License and EXACT shall thereafter have sixty (60) days in which to
elect to substitute into this Agreement all the financial terms and conditions
of such Subsequent Comparable License by delivering written notice of such
election to Genzyme within said sixty (60) day period.

ARTICLE 5.  REPORTS AND RECORDS

5.1                                 EXACT shall maintain true, accurate and
complete books of account, records and files containing an accurate record of
all data reasonably necessary for the full computation and verification of sales
and the determination of the amounts payable under Article 4 hereof for a period
of at least four (4) years following the period of each report required by
Section 5.2 below.  Said books and records shall be kept at EXACT’s principal
place of business and shall be in accordance with generally accepted accounting
principles, consistently applied.  Said books and records, to the extent not
previously audited, shall be available for inspection by an independent
certified public accountant selected by

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Genzyme (or its licensor of the Patent Rights) and reasonably acceptable to
EXACT, upon ten (10) business days advance written notice and during regular
business hours, for three (3) years following the end of the calendar year to
which they pertain in order to enable Genzyme (or its licensor of the Patent
Rights) to ascertain the correctness of any report and/or payment made under
this Agreement.  Such inspections may be conducted no more than once in any
twelve (12) month period and, except as provided below, shall be conducted at
the expense of Genzyme (or its licensor, as the case may be).  If such
examination reveals that royalties have been misstated, any adjustment shall be
promptly refunded or paid, as appropriate.  Genzyme (or its licensor, as the
case may be) shall pay the fees and expenses of the accountant engaged to
perform the audit, unless such audit reveals an underpayment of five percent
(5%) or more for the period examined, in which case EXACT shall pay all
reasonable costs and expenses incurred by Genzyme (or its licensor, as the case
may be) in the course of making such determination, including without limitation
the fees and expenses of the accountant.

5.2                                 Within forty-five (45) days after March 31,
June 30, September 30 and December 31, of each year in which this Agreement is
in effect, EXACT shall deliver to Genzyme full, true and accurate reports of its
activities relating to this Agreement during the preceding three month period. 
These reports shall include at least the following:

(a)           the total actual billings for Diagnostic Services on a
country-by-country basis during the applicable period;

(b)           the total gross sales of Licensed Reagents and Kits, each
individually, on a country-by-country basis during the applicable period;

(c)           the calculation of Net Service Revenues and Net Sales on a
country-by-country basis for the applicable period, including a detailed listing
of the applicable deductions permitted under Sections 1.11 and 1.12 hereof on an
item-by-item basis and a detailed explanation of the calculation of Net Service
Revenues and Net Sales of any Combination Services or combination products; and

(d)           the calculation of total royalties due in U.S.  dollars, together
with the exchange rates used for conversion, to the extent applicable.

5.3                                 With each such report, EXACT shall pay to
Genzyme the royalties due and payable as provided for in Section 4.2.  To the
extent that royalties for the applicable period are creditable against minimum
royalties paid pursuant to Section 4.3 hereof, EXACT shall so report.  If no
royalties are due, EXACT shall so report.

ARTICLE 6.  PATENT PROSECUTION; INFRINGEMENT

6.1                                 The prosecution, filing and maintenance of
all patents and the expense thereof shall be the responsibility of Genzyme
(and/or its licensor of the Patent Rights).

6.2                                 (a)           EXACT agrees to provide
Genzyme with prompt written notice after becoming aware of any infringement of
any of the Patent Rights.

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(b)           Genzyme (or its licensor, as the case may be) shall have the
right, under its control and at its expense, to prosecute any third party
infringement of the Patent Rights or to defend the Patent Rights in any
declaratory judgment action brought by a third party which alleges the
invalidity, unenforceability or non-infringement of any Patent Right.  EXACT
agrees to cooperate fully in any action under this Section 6.2, provided that
Genzyme (or its licensor, as the case may be) reimburses EXACT for its
reasonable costs and expenses incurred in connection with providing such
assistance.

(c)           In the event that

(i)                                     EXACT notifies Genzyme that a third
party is conducting activities in the Field that infringe the Patent Rights in
any country,

(ii)                                  said third party continues to infringe for
one hundred and eighty (180) days after receipt by Genzyme of such notice and
does not obtain a license from Genzyme under the applicable Patent Rights within
such period, and

(iii)                               EXACT can demonstrate to Genzyme’s
reasonable satisfaction through written documentation that (A) EXACT has Net
Sales or Net Service Revenues in one or more countries in which there is any
Valid Claim within the Patent Rights, and (B) the infringing activities of said
third party have resulted in annualized income to said third party equal to or
greater than (x) seven million five hundred thousand dollars ($7,500,000)
worldwide in countries in which there is any Valid Claim within the Patent
Rights (determined based on Net Sales or Net Service Revenues of the four (4)
completed and immediately preceding calendar quarters) or (y) fifteen percent
(15%) of EXACT’s annualized Net Sales or Net Service Revenues (as applicable)
worldwide in countries in which there is any Valid Claim within the Patent
Rights (determined based on Net Sales or Net Service Revenues of the four (4)
completed and immediately preceding calendar quarters), whichever is greater,

then, after making such a demonstration, EXACT may withhold up to fifty percent
(50%) of the royalty payments that would otherwise be payable to Genzyme on Net
Services Revenues from Diagnostic Services covered in whole or in part by the
infringed Patent Rights or on Net Sales of Licensed Reagents or Kits covered in
whole or in part by the infringed Patent Rights, as applicable, in such
countries until such time as the infringement is abated; provided, however, that
in the event that Genzyme (or its licensor, as the case may be) either (A) fails
to use good faith efforts to undertake the prosecution of such third party
infringement or otherwise Resolve such infringement within two hundred and forty
(240) days after receipt by Genzyme of the notice delivered by EXACT pursuant to
clause (c)(i) above or (B) delivers written notice to EXACT that Genzyme (or its
licensor, as the case may be) does not intend to undertake the prosecution of
such third party infringement, then EXACT may withhold one hundred percent
(100%) of the aforementioned royalty payments; provided further that, if EXACT
withholds such royalty payments and Genzyme (or its licensor, as the case may
be) either successfully Resolves such infringement or undertakes the prosecution
of such third party

11

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infringement and obtains a favorable judgment, settlement, consent judgment or
other final disposition of the suit, EXACT shall resume full payment of the
aforementioned royalties due under this Agreement on Net Service Revenues and
Net Sales in such countries upon receipt of either written notice of the
successful abatement of such infringement by prosecution or Resolution signed by
an officer of Genzyme or a copy of an official, written evidence of such
favorable judgment, settlement, consent judgment or other final disposition;
provided further that in the event that Genzyme (or its licensor, as the case
may be) undertakes the prosecution of such infringement and obtains a favorable
settlement, an order to dismiss shall constitute adequate official written
evidence for purposes of this sentence.  For purposes of this clause (c),
“Resolve(s)” or “Resolution” means the cessation of such third party
infringement other than as a result of prosecution, including without limitation
the grant of a nonexclusive license under the Patent Rights or the
discontinuance by such third party of the infringing activities.

(d)           If Genzyme notifies EXACT in writing within ten (10) days of
receiving written documentation pursuant to Section 6.2(c)(iii) above that
Genzyme is not reasonably satisfied that EXACT has demonstrated conditions
sufficient to justify the  withholding of royalty payments under Section 6.2(c)
above, then, until final resolution of the dispute, EXACT shall deposit all
withheld royalty payments otherwise due and payable to Genzyme into an escrow
account established by EXACT exclusively for such purpose in a recognized
commercial banking institution reasonably selected by EXACT and promptly
identified by written notice from EXACT to Genzyme.  If the parties are unable
to resolve the dispute within thirty (30) days after EXACT’s receipt of
Genzyme’s notice, then the dispute shall immediately be referred to one (1)
executive officer of each party, chosen in the sole discretion of that party,
who shall negotiate with each other in good faith to resolve the dispute during
the period ending thirty (30) days after the date of such referral.  If the
designated officers of the parties are unable to resolve the dispute within such
thirty (30) day period, the dispute shall be referred to arbitration pursuant to
Article 11 hereof.  If such officers or the arbitrator, as applicable, resolves
the dispute in favor of Genzyme, then the amounts held in escrow plus all
interest accrued thereon shall be promptly paid to Genzyme in same day funds and
EXACT shall resume full payment of royalties under this Agreement.

(e)           In the event that EXACT withholds royalty payments pursuant to
Section 6.2(c), EXACT shall include the amount of such withheld royalties and
the basis for the calculation thereof on a country-by-country basis in the
reports deliverable by EXACT to Genzyme pursuant to Section 5.2 hereof as
distinct line items.

(f)            EXACT hereby acknowledges and agrees that Roche has rights under
the Patent Rights under an agreement with JHU and, therefore, activities by
Roche in accordance with such agreement with JHU will not be subject to this
Section 6.2.

ARTICLE 7.  TERM AND TERMINATION

7.1                                 Unless earlier terminated as hereinafter
provided, this Agreement shall remain in full force and effect until the
expiration of the last to expire Patent Rights.  Royalties on Net Service
Revenues from Diagnostic Services and on Net Sales of Licensed Reagents and

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Kits covered by the Gene Patent Rights shall cease upon the expiration of the
last to expire Gene Patent Right.  Royalties on Net Service Revenues of
Diagnostic Services and on Net Sales of Licensed Reagents and Kits covered by
the Methodology Patent Rights shall cease upon the expiration of the last to
expire Methodology Patent Right.

7.2                                 If (a) Genzyme, acting reasonably,
determines that EXACT has ceased to carry on its business with respect to the
performance of Diagnostic Services in the Field and/or the provision of Licensed
Reagents and/or Kits in the Field in any country in North America or Europe for
a period of more than six (6) months with no plan to resume such business within
the following three (3) months, then (b) Genzyme shall have the right to
terminate this Agreement and all rights, privileges and license hereunder
granted with respect to such Diagnostic Services and/or Licensed Reagents and/or
Kits, as applicable, upon six(6) months prior written notice to EXACT; provided,
however, that if EXACT is temporarily unable to carry on such business due to a
corporate reorganization or restructuring of EXACT, then the six (6) month time
period set forth in clause (a) of this Section 7.2 shall be reasonably extended
to accommodate such corporate circumstance by a period to be mutually agreed
upon by the parties, which extension period shall not exceed six (6) months. 
Such termination shall become effective immediately upon the conclusion of such
notice period unless EXACT shall have resumed such business in good faith prior
to the expiration of such notice period.

7.3                                 Should EXACT fail to pay Genzyme any amounts
as are due and payable hereunder, Genzyme shall have the right to terminate this
Agreement upon forty-five (45) days prior written notice, unless EXACT shall pay
Genzyme within said forty-five (45) day period such delinquent amounts and all
interest due and payable thereon.  If EXACT shall not have paid all such
delinquent amounts and interest due and payable thereon within said period,
Genzyme, at its sole option, may immediately terminate this Agreement and all
rights, privileges and license hereunder granted.

7.4                                 EXACT shall have the right to terminate this
Agreement and all rights, privileges and license hereunder granted at any time
upon sixty (60) days prior written notice to Genzyme.

7.5                                 Upon any material breach or default of this
Agreement by EXACT, other than those delineated in Sections 7.2 and 7.3, which
shall always take precedence in that order over any material breach or default
referred to in this Section 7.5, Genzyme shall have the right to terminate this
Agreement and the rights, privileges and license hereunder granted upon sixty
(60) days prior written notice to EXACT.  Such termination shall become
effective immediately at the conclusion of such notice period unless EXACT shall
have cured any such breach or default prior to the expiration of said sixty (60)
day period.

7.6                                 (a)           If no royalties have been paid
by EXACT with respect to any Diagnostic Service within two (2) years after the
First Commercial Sale by EXACT of a Diagnostic Service, the rights, privileges
and license granted under this Agreement to EXACT under Section2.1 (a) hereof
shall automatically terminate.

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(b)           If no royalties have been paid by EXACT with respect to any
Licensed Reagent within two (2) years after the First Commercial Sale of a
Licensed Reagent, the rights, privileges and license granted under this
Agreement to EXACT under Section 2.1 (b) hereof shall automatically terminate.

7.7                                 (a)           If EXACT fails to make a
510(k) or PMA submission for a Kit to the FDA (or the equivalent of such
submissions as may be required by the FDA at such time) within five(5) years
after the Effective Date, Genzyme may, in its sole discretion, elect to
terminate the rights, privileges and license granted under Section 2.1 (c)
hereof in any or each country in which Genzyme has Patent Rights unless such
license grant is sooner terminated according to the terms of this Agreement.

(b)           If EXACT fails to achieve annual Net Sales of Licensed Reagents
and Kits for use in the Field of ten million dollars ($10,000,000) or more
within four (4) years after the First Commercial Sale of a Kit, Genzyme may, in
its sole discretion, elect to terminate the rights, privileges and license
granted under Section 2.1 (c) hereof in any and each country in which Genzyme
has Patent Rights unless such license grant is sooner terminated according to
the terms of this Agreement.

7.8                                 If EXACT materially fails to perform in
accordance with clauses (i), (ii) or (iii) of Section 3.1 hereof, Genzyme may
elect to terminate the rights, privileges and license granted under Section 2.1
with respect to the subject matter of the clause or clauses of Section 3.1 under
which EXACT has materially failed to perform, as set forth in Section 3.2,
hereof upon thirty (30) days prior written notice to EXACT.  Notwithstanding the
foregoing, any termination of the license granted under any one clause of
Section 2.1 pursuant to this Section 7.8 will be effective only with respect to
the subject matter of the clause of Section 3.1 under which EXACT has materially
failed to perform, and the remaining clauses of Section 3.1 and the remaining
rights granted under 2.1 shall be unaffected by such termination.

7.9                                 Upon any termination of this Agreement in
its entirety or any of the rights, privileges and licenses granted under Section
2.1 hereof, EXACT shall be entitled to finish any work-in-progress and to sell
any completed inventory of Licensed Reagents or Kits, as applicable, which
remain on hand as of the date of the termination provided that EXACT pays
Genzyme the royalties applicable to said subsequent sales in accordance with the
terms and conditions set forth in this Agreement.

7.10                           (a)           In the event that Genzyme
terminates this Agreement and the rights, privileges and licenses hereunder
granted pursuant to Section 7.2 above, then Genzyme shall refund to EXACT the
pro rata share of the amount equal to the sum of (i) any payment made by EXACT
pursuant to Section 4.3 hereof on January 1 of the calendar year in which the
effective date of such termination falls plus (ii) any payment made by EXACT
pursuant to Section 4.4 hereof on the anniversary of the Effective Date
immediately preceding the effective date of such termination plus (iii) one-half
of any payment made by EXACT pursuant to Section 4.5 hereof if the license
granted under Section 2.1 (c) is being terminated and if such payment was made
by EXACT within the six (6) month period immediately preceding the effective
date of such termination less (iv) the aggregate

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amount of any payments made by Genzyme to JHU in that Year under the JHU License
Agreement based on the payments described in clauses (i), (ii) and (iii) above.

(b)           In the event that Genzyme terminates the license granted under
Section 2.1 (a) hereof with respect to Diagnostic Services pursuant to Section
7.6 or 7.8 hereof, then Genzyme shall refund to EXACT the pro rata share of the
amount equal to the sum of (i) any payment made by EXACT pursuant to Section
4.3(a) hereof on January 1 of the calendar year in which the effective date of
such termination falls plus (ii) any payment made by EXACT pursuant to Section
4.4(a) hereof on the anniversary of the Effective Date immediately preceding the
effective date of such termination less (iii) the amount of any payment made by
Genzyme to JHU in that Year based on the payments described in clauses (i) and
(ii) above.

(c)           In the event that Genzyme terminates the rights, privileges and
license granted under Section 2.1 (b) or (c) hereof with respect to Licensed
Reagents and Kits pursuant to Sections 7.7 or 7.8 hereof, then Genzyme shall
refund to EXACT the pro rata share of the amount equal to the sum of (i) any
payment by EXACT to Genzyme pursuant to Section 4.3(b) hereof on January 1 in
which the calendar year of the effective date of such termination falls plus
(ii) any payment made by EXACT pursuant to Section 4.4(b) hereof on the
anniversary of the Effective Date immediately preceding the effective date of
such termination plus (iii) one-half of any payment made by EXACT pursuant
Section 4.5 hereof to if the license granted under Section 2.1 (c) is being
terminated and if such payment was made to Genzyme within six (6) months
immediately preceding the effective date of such termination less (iv) the
aggregate amount of any payments made by Genzyme to JHU in that Year based on
the payments described in clauses (i), (ii) and (iii) above.

(d)           The pro rata share of any amounts to be refunded by Genzyme
pursuant to this Section 7.10 shall be determined based on either (i) the
portion of the twelve (12) month period after said anniversary of the Effective
Date or (ii) the portion of said calendar year, as applicable, during which this
Agreement shall not be in effect.  In no event shall any amounts be refundable
by Genzyme to the extent they have been credited by Genzyme against royalties
payable by EXACT in accordance with Sections 4.3 and/or 4.4 hereof.  Interest   
paid to Genzyme pursuant to Section 4.9 hereof or on any amounts held in escrow
during the pendency of a dispute shall not be included in the calculation of any
amounts refundable by Genzyme.

(e)           Any and all amounts refundable by Genzyme to EXACT pursuant to
this Section 7.10 shall be paid to EXACT within thirty (30) days after the
applicable effective date of the termination.

7.11                           Upon the expiration or the earlier termination of
this Agreement for any reason, nothing herein shall be construed to release
either party from any obligation that matured prior to the effective date of
such expiration or the termination.  The provisions of Articles 5, 8, 10, 11,
13, 18 and 21, Section 4.6, 7.9, 7.10 and this Section 7.11 shall survive the
expiration or earlier termination of this Agreement.

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ARTICLE 8.  INDENCVIFICATION AND INSURANCE

8.1                                 (a)           Subject to the provisions of
Section 8.3 hereof, EXACT shall indemnify, defend and hold harmless Genzyme,
JHU, The John Hopkins Health System (“JHHS”) and their respective present and
former officers, directors, trustees, employees, consultants, agents, students,
faculty, treating and consulting physicians, inventors of the Patent Rights,
subsidiaries, successors, heirs and assigns (collectively, the “Genzyme
Indemnitees”) against any liability, damage, loss or expense (including
reasonable attorneys’ fees and expenses of litigation) incurred by or imposed
upon the Genzyme Indemnitees, or any one of them, in connection with any claims,
suits, actions, demands or judgments arising out of (i) the design, sale, use,
manufacture or promotion by EXACT and its officers, directors, employees,
representatives and agents, of any process, service or product relating to, or
developed, manufactured, used or commercialized pursuant to, this Agreement and
(ii) the practice and use of the Patent Rights by EXACT and its officers,
directors, employees, representatives and agents.

(b)           EXACT’s indemnification under this Section 8.1 shall not apply to
any liability, damage, loss or expense to the extent that it is directly
attributable to the negligence, reckless misconduct or intentional misconduct of
the Genzyme Indemnitees.

(c)           EXACT agrees, at its own expense, to provide attorneys to defend
against any actions brought or filed against any Genzyme Indemnitee with respect
to the subject of indemnity contained herein, whether or not such actions are
rightfully brought, such attorneys to be reasonably acceptable to Genzyme and
not to be subject to any conflict of interest in representing any of the Genzyme
Indemnitees nor to have been deemed within the preceding ten (10) years by any
Genzyme Indemnitee to have provided unsatisfactory legal representation of such
Genzyme Indemnitee.

8.2                                 (a)           Subject to the provisions of
Section 8.3 hereof Genzyme shall indemnify, defend and hold harmless EXACT and
its present and former officers, directors, employees, agents, consultants,
successors, heirs and assigns (collectively, the “EXACT Indemnitees”) against
any liability, damage, loss or expense (including reasonable attorney’s fees and
expenses of litigation) incurred by or imposed upon the EXACT Indemnitees, or
anyone of them, in connection with any claims, suits, actions, demands or
judgments arising out of (i) the design, sale, use, manufacture or promotion by
Genzyme and its officers, directors, employees, representatives and agents, of
any process, service or product utilizing the Patent Rights in the Field and
(ii) the practice and use of the Patent Rights in the Field by Genzyme and its
officers, directors, employees, representatives and agents.

(b)           Genzyme’s indemnification under this Section 8.2 shall not apply
to any liability, damage, loss or expense to the extent it is directly
attributable to the negligence, reckless misconduct or intentional misconduct of
the EXACT Indemnitees.

(c)           Genzyme agrees, at its own expenses to provide attorneys to defend
against any actions brought or filed against any EXACT Indemnitee with respect
to the subject of indemnity contained herein, whether or not such actions are
rightfully brought, such

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attorneys to be reasonably acceptable to EXACT and not to be subject to any
conflict of interest in representing any of the EXACT Indemnitees not to have
been deemed within the preceding ten (10) years by any EXACT Indemnitee to have
provided unsatisfactory legal representation of such EXACT Indemnitee.

8.3                                 In the event any such action is commenced or
claim made or threatened against an indemnified party covered by Section 8.1 or
8.2 hereof, the indemnified party shall promptly notify the indemnifying party
in writing of such event.  The failure of indemnified party to deliver notice to
the indemnifying party within a reasonable time after the commencement of any
such action, if materially prejudicial to the ability of the indemnifying party
to defend such action, shall relieve the indemnifying party of any liability to
the indemnified party under this Article 8 solely with respect to such action,
but the failure to deliver notice to the indemnifying party will not relieve it
of any liability with respect to such action that it may have to the indemnified
party otherwise than under this Article 8.  The indemnifying party shall assume,
with the reasonable cooperation of the indemnified party, the investigation and
defense of, and may settle that part of, any such claim or action commenced or
made against the indemnified party which relates to the indemnifying party’s
indemnification and the indemnifying party may take such other steps as may be
necessary to protect itself.  The indemnifying party shall not be liable to
indemnified party on account of any settlement of any such claim or litigation
affected without the indemnifying party’s express written consent, which consent
shall not be unreasonably withheld or delayed.  The right of the indemnifying
party to assume the defense of any action shall be limited to that part of the
action commenced against an indemnified party which relates to the indemnifying
party’s obligation of indemnification and holding harmless.

8.4                                 (a)           Beginning at such time as any
Diagnostic Service, Licensed Reagent or Kit relating to, or developed pursuant
to, this Agreement is being made available (other than for the purpose of
obtaining regulatory approvals) by EXACT, EXACT shall, at its sole cost and
expense, procure and maintain commercial general liability insurance, applicable
worldwide, in amounts not less than two million dollars ($2,000,000) per
incident and two million dollars ($2,000,000) annual aggregate and naming
Indemnitees as additional insureds.  Such commercial general liability insurance
shall provide (i) product liability coverage and (ii) contractual liability
coverage for EXACT’s indemnification under Section 8.1 of this Agreement.  If
EXACT elects to self-insure all or part of the limits described above (including
deductibles or retentions that are in excess of two hundred and fifty thousand
dollars ($250,000) annual aggregate) such self-insurance program must be
acceptable to Genzyme.  The minimum amounts of insurance coverage required under
this Section 8.4(a) shall not be construed to create a limit of EXACT’s
liability with respect to its indemnification obligation under Section 8.1 of
this Agreement.

(b)           Genzyme shall, at its sole cost and expense, procure and maintain
commercial general liability insurance, applicable worldwide, in amounts not
less than two million dollars ($2,000,000) per incident and two million dollars
($2,000,000) annual aggregate and naming the EXACT Indemnitees as additional
insureds.  Such commercial general liability insurance shall provide (i) product
liability coverage and (ii) contractual liability coverage for Genzyme’s
indemnification under Section 8.2 of this Agreement.  If

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Genzyme elects to self-insure all or part of the limits described above
(including deductibles or retentions that are in excess of two hundred and fifty
thousand dollars($250,000) annual aggregate) such self-insurance program must be
acceptable to EXACT.  The minimum amounts of insurance coverage required under
this Section 8.4(a) shall not be construed to create a limit of Genzyme’s
liability with respect to its indemnification obligation under Section 8.2 of
this Agreement.

(c)           Each party shall provide the other with written evidence of such
insurance upon request of the other party.  Each party shall provide the other
with written notice at least thirty (30) days prior to the cancellation,
non-renewal or material change in such insurance.  If such party does not obtain
replacement insurance providing comparable coverage within such thirty (30) day
period, the other party shall have the right to terminate this Agreement and the
rights, privileges and license granted hereunder effective at the end of such
thirty (30) day period without any notice or additional waiting periods.

(d)           Each party shall maintain such comprehensive general liability
insurance beyond the expiration or termination of this Agreement during (a) the
period that any process, service or product relating to, or developed pursuant
to, this Agreement is being made available (other than for the purpose of
obtaining regulatory approvals) by EXACT and (b) a reasonable period after the
period referred to in clause (a) above which in no event shall be less than
fifteen (15) years.

ARTICLE 9.  REPRESENTATIONS, WARRANTIES AND DISCLAIMERS

9.1                                 (a)           Genzyme hereby represents and
warrants to EXACT that it has the right and power to enter into this Agreement,
to extend the rights and licenses granted herein and to perform its obligations
hereunder, and that this Agreement is a valid and binding agreement, enforceable
in accordance with its terms.

(b)           Genzyme further represents and warrants to EXACT that Genzyme is
not in material breach of the JHU License Agreement as of the Effective Date,
and that Genzyme will use commercially reasonable and diligent efforts to comply
with all of its material obligations and duties with regard to the Patent Rights
under the JHU License Agreement, including without limitation any provisions of
the JHU Agreement as may be reasonably necessary to maintain in effect this
Agreement or preserve EXACT’s rights under this Agreement, including without
limitation the preservation of EXACT’s rights hereunder in the event that
Genzyme shall breach or default on its obligations under the JHU License
Agreement.

(b)           EXACT hereby represents and warrants to Genzyme that it has the
right and power to enter into this Agreement and to perform its obligations
hereunder, and that this Agreement is a valid and binding agreement, enforceable
in accordance with its terms.  EXACT agrees that it shall comply with all
applicable local, state, Federal and international laws and regulations relating
to the development, design, manufacture, sale, use in commerce and promotion of
Diagnostic Services, Licensed Reagents and Kits.

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9.2                                 EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN
SECTION 9.1, GENZYME MAKES NO WARRANTY, EXPRESS OR IMPLIED, INCLUDING, WITHOUT
LIMITATION, ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR OF FITNESS FOR A
PARTICULAR PURPOSE WITH RESPECT TO ANY PATENT, TRADEMARK, SOFTWARE, NONPUBLIC OR
OTHER INFORMATION, OR TANGIBLE RESEARCH PROPERTY, LICENSED OR OTHERWISE PROVIDED
TO EXACT HEREUNDER AND HEREBY DISCLAIMS THE SAME.

9.3                                 GENZYME DOES NOT WARRANT THE VALIDITY OF THE
PATENT RIGHTS LICENSED HEREUNDER AND MAKES NO REPRESENTATION WHATSOEVER WITH
REGARD TO THE SCOPE OF THE LICENSED PATENT RIGHTS OR THAT SUCH PATENT RIGHTS MAY
BE EXPLOITED BY EXACT WITHOUT INFRINGING OTHER PATENTS.

9.4                                 NOTWITHSTANDING ANY OTHER PROVISION OF THIS
AGREEMENT, EACH OF THE PARTIES HERETO DISCLAIMS ALL OBLIGATIONS ON THE PART OF
SUCH PARTY FOR DAMAGES, INCLUDING BUT NOT LIMITED TO DIRECT, INDIRECT, SPECIAL
AND CONSEQUENTIAL DAMAGES, ATTORNEYS’ AND EXPERTS’ FEES AND EXPENSES, AND COURT
COSTS (EVEN IF SUCH PARTY HAS BEEN ADVISED OF THE PROBABILITY OF SUCH DAMAGES,
FEES, EXPENSES AND COSTS) ARISING OUT OF OR IN CONNECTION WITH THE MANUFACTURE,
USE, SALE OR PROVISION OF THE LICENSED REAGENTS, DIAGNOSTIC SERVICES UTILIZING
THE LICENSED PROCESSES AND KITS BY THE OTHER PARTY.  EXACT ASSUMES ALL
RESPONSIBILITY AND LIABILITY FOR ANY LOSS OR DAMAGES CAUSED BY A LICENSED
REAGENT, DIAGNOSTIC SERVICE OR KIT MANUFACTURED, USED, SOLD OR PROVIDED BY
EXACT.  GENZYME ASSUMES ALL RESPONSIBILITY AND LIABILITY FOR ANY LOSS OR DAMAGES
CAUSED BY A LICENSED REAGENT, DIAGNOSTIC SERVICE OR KIT MANUFACTURED, USED, SOLD
OR PROVIDED BY GENZYME.

ARTICLE 10.  NOTICES

10.1                           Any consent, notice or report required or
permitted to be given or made under this Agreement shall be in writing,
delivered (i) by certified or registered mail (postage prepaid, return receipt
requested), (ii) by facsimile (and promptly confirmed by personal delivery,
courier or next business day service of a nationally recognized courier service
of good repute), (iii) by a next business day service of a nationally recognized
courier service of good repute (with evidence of delivery) or (iv) by courier
(postage prepaid and signature required), and in any case addressed to the other
party at its address set forth in this Article 10, and shall be effective upon
receipt by the addressee.

10.2                           Reports, notices and other communications from
EXACT to Genzyme as provided hereunder shall be sent to:

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President, Molecular Oncology Division

Genzyme Corporation

One Mountain Road

P.O.  Box 9322

Framingham, MA 01701-9322

Facsimile: (508) 271-2604

with a copy to

Chief Legal Officer

Genzyme Corporation

One Kendall Square

Cambridge, MA 02139

Facsimile: (617) 252-7553

or to such other individual or address as shall hereafter be furnished by
written notice to EXACT in accordance with this Article 10.

10.3                           Reports, notices and other communications from
Genzyme to EXACT as provided hereunder shall be sent to:

President

EXACT Laboratories, Inc.

63 Great Road

Maynard, MA 01754

Facsimile: (978) 897-3481

or to such other individual or address as shall hereafter be furnished by
written notice to Genzyme in accordance with this Article 10.

ARTICLE 11.  ARBITRATION

11.1                           Any controversy or claim arising out of, or
relating to any provisions of this Agreement or the breach thereof which cannot
otherwise be resolved by good faith negotiations between the parties, or by any
form of Alternate Dispute Resolution other than arbitration which may be
mutually acceptable to the parties, shall be resolved by final and binding
arbitration in Boston, Massachusetts under the rules of the American Arbitration
Association, or the Patent Arbitration Rules if applicable, then obtaining.

The arbitration shall be subject to the following terms:

(a)           The number of arbitrators shall be one (1).

(b)           The arbitrator shall be an independent, impartial third party
having no direct or indirect personal or financial relationship to any of the
parties to the dispute, who has agreed to accept the appointment as arbitrator
on the terms set out in this Section 11.1.

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(c)           The arbitrator shall be an active or retired attorney, law
professor, or judicial officer with at least five (5) years experience in the
biotechnology or pharmaceuticals industries and a familiarity with the laws
governing proprietary rights in intellectual property.

(d)           The arbitrator shall be selected as follows:

(i)                                     Each party shall submit a description of
the matter to be arbitrated to the American Arbitration Association at its
Regional Office in Boston, Massachusetts.  Said Association shall submit to the
parties a list of the arbitrators available to arbitrate any dispute between
them.  Thereafter, each party shall select, in numerical order, those persons on
said list acceptable as arbitrators and return the same to the Association.  The
first arbitrator acceptable to both parties shall be deemed the selected
arbitrator with respect to the dispute then at issue under this Agreement.  In
the event of a failure to select a mutually agreeable arbitrator, the
Association shall be requested to submit as many subsequent lists of arbitrators
as shall be necessary to effect a mutual selection.

(ii)                                  If the method of selection set out in
paragraph (d)(i) above fails for any reason, then either party may petition any
state or federal court in Massachusetts having jurisdiction for appointment of
the arbitrator in accordance with applicable law, provided that the arbitrator
must satisfy the requirements of paragraphs (b) and (c) above.

(e)           The arbitrator shall announce the decision and/or award in writing
accompanied by written findings explaining the facts determined in support of
the decision and/or award, and any relevant conclusions of law.

(f)            Unless otherwise provided in this Section 11.1 or extended by
agreement of the parties, each party shall submit an initial request for
designation of an arbitrator within thirty (30) days after receipt of the first
list of available arbitrators pursuant to Section 11.1 (d) of this Agreement,
the dispute shall be submitted to the arbitrator within ninety (90) days after
the arbitrator is selected, and a decision shall be rendered within thirty (30)
days after the dispute is submitted.

(g)           The fees of the arbitrator and any other costs and fees associated
with the arbitration shall be paid in accordance with the decision of the
arbitrator.

(h)           The arbitrator shall have no power to add to, subtract from, or
modify any of the terms or conditions of this Agreement.  Any award rendered in
such arbitration may be enforced by either party in either the courts of the
Commonwealth of Massachusetts, or in the United States District Court for the
District of Massachusetts, to whose jurisdiction for such purposes Genzyme and
EXACT each hereby irrevocably consents and submits.

11.2                           Notwithstanding the foregoing, nothing in this
Article shall be construed to waive any rights or timely performance of any
obligations existing under this Agreement.

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ARTICLE 12.  RESTRICTIONS ON USE OF NAMES

12.1                           EXACT shall not use the name of Genzyme or its
divisions, JHU, JHHS or their respective directors, officers, trustees,
affiliates, employees, faculty, students and the inventor(s) of the Patent
Rights or any adaptations or contractions thereof in any advertising,
promotional or sales literature without the prior written consent of Genzyme or
JHU in each case, as applicable; provided, however, that EXACT (a) may refer to
publications by employees of Genzyme in the scientific literature and (b) may
state that a license from Genzyme has been granted as herein provided.  With
respect to reports to public agencies that are required by law, EXACT shall
provide Genzyme with a reasonable opportunity to review the use of its name in
each such report reasonably in advance of its submission.

12.2                           EXACT shall not disclose this Agreement or any of
the terms or conditions of this Agreement to any third party without the prior
written consent of Genzyme except and to the extent required to comply with
applicable laws or regulations; provided, that EXACT delivers prior written
notice to Genzyme of any disclosure required by applicable laws or regulations
and takes all reasonable and lawful actions to obtain confidential treatment for
such disclosure and, if possible, to minimize the extent of such disclosure.

13.                                 CONFIDENTIALITY

13.1                           During the term of this Agreement, each party
(the “disclosing party”) may communicate to the other party (the “receiving
party”) information which it considers to be confidential (“Confidential
Information”).  All Confidential Information shall be specifically designated as
confidential.  Such Confidential Information may include, without limitation,
trade secrets, know-how, inventions, technical data or specifications, testing
methods, business or financial information, research and development activities,
product and marketing plans, and customer and supplier information. 
Confidential Information that is disclosed in writing shall be marked with a
legend indicating its confidential status.  Confidential Information that is
disclosed orally or visually shall be documented in a written notice prepared by
the disclosing party and delivered to the receiving party within thirty (30)
days of the date of disclosure; such notice shall summarize the Confidential
Information disclosed to the receiving party and reference the time and place of
disclosure.

13.2                           The receiving party agrees that it shall: (a)
maintain all Confidential Information in strict confidence, except that the
receiving party may disclose or permit the disclosure of any Confidential
Information to its directors, officers, employees, consultants, and advisors who
are obligated to maintain the confidential nature of such Confidential
Information and who need to know such Confidential Information for the purposes
set forth in this Agreement; (b) use all Confidential Information solely for the
purposes set forth in this Agreement; and (c) allow its directors, officers,
employees, consultants, and advisors to reproduce the Confidential Information
only to the extent necessary to effect the purposes set forth in this Agreement,
with all such reproductions being considered Confidential Information.

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13.3                           The obligations of the receiving party under
Section 13.2 above shall not apply to the extent that the receiving party can
demonstrate that certain Confidential Information: (a) was in the public domain
prior to the time of its disclosure under this Agreement; (b) entered the public
domain after the time of its disclosure under this Agreement through means other
than an unauthorized disclosure resulting from an act or omission by the
receiving party; (c) was independently developed or discovered by the receiving
party without use of the Confidential Information; (d) is or was disclosed to
the receiving party at any time, whether prior to or after the time of its
disclosure under this Agreement, by a third party having no fiduciary
relationship with the disclosing party and having no obligation of
confidentiality with respect to such Confidential Information; or (e) is
required to be disclosed to comply with applicable laws or regulations, or with
a court or administrative order, provided, that the disclosing party receives
prior written notice of such disclosure and that the receiving party takes all
reasonable and lawful actions to obtain confidential treatment for such
disclosure and, if possible, to minimize the extent of such disclosure.

13.4.                        The obligations set forth in this Article 13 shall
remain in effect for a period of five (5) years after the expiration or the
earlier termination of this Agreement.

ARTICLE 14.  PATENT MARKING

14.                                 EXACT agrees to mark any Kits, Licensed
Reagents or promotional materials, technical literature and the like that
describe Kits, Licensed Reagents or Diagnostic Services with all applicable
patent numbers, and to indicate “Patent Pending” status in accordance with each
applicable country’s patent laws.

ARTICLE 15.  INDEPENDENT CONTRACTOR

15.                                 For the purpose of this Agreement and all
services to be provided hereunder, both parties shall be, and shall be deemed to
be, independent contractors and not agents or employees of the other.  Neither
party shall have authority to make any statements, representations or
commitments of any kind, or to take any action, that will be binding on the
other party.

ARTICLE 16.  SEVERABILITY

16.                                 If any one or more of the provisions of this
Agreement shall be held to be invalid, illegal or unenforceable, the validity,
legality or enforceability of the remaining provisions of this Agreement shall
not in any way be affected or impaired thereby unless the invalid provisions are
of such essential importance to this Agreement that it is to be reasonably
assumed that the parties would not have entered into this Agreement without the
invalid provisions.

ARTICLE 17.  NON-ASSIGNABILITY

17.                                 Neither this Agreement nor any part hereof
shall be assignable by either party without the express prior written consent of
the other, which shall not be unreasonably withheld.  Any attempted assignment
without such consent shall be void.  Notwithstanding the foregoing, such consent
shall not be required for the assignment of this Agreement (i) by

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EXACT in connection with the sale or transfer of all or substantially all of the
business or assets of EXACT however structured, or (ii) by Genzyme in
conjunction with the transfer of all or substantially all of the business or
assets of Genzyme or all or substantially all of the business or assets
allocated to its Molecular Oncology Division however structured; provided, in
any such case, that the assignor promptly notifies the other party hereto of
such assignment and the assignee assumes all of the assignor’s obligations
hereunder in writing, with a copy of such written assumption (which may be
redacted to the extent reasonably necessary to protect confidential information)
to be promptly delivered to the other party hereto.

ARTICLE 18.  NON-SOLICITATION

18.                                 During the term of this Agreement and during
the period ending two (2) years after the expiration or earlier termination of
this Agreement, neither party shall, without the prior written consent of the
other, solicit the employment of, or employ, any person in any capacity who, at
any time during the term of this Agreement, shall have been an employee of the
other party.

ARTICLE 19.  ENTIRE AGREEMENT

19.                                 This Agreement constitutes the entire
agreement between the parties with respect to the subject matter and supersedes
any prior agreements and understandings between the parties relating to the
subject matter hereof.  No oral agreement, conversation or representation
between any officers, agents or employees of the parties hereto either before or
after the execution of this Agreement shall affect or modify any of the terms or
obligations herein contained.

ARTICLE 20.  MODIFICATIONS IN WRITING

20.                                 No change, modification, extension,
termination or waiver of this Agreement, or any of the provisions herein
contained, shall be valid unless made in writing and signed by a duly authorized
representative of each party.

ARTICLE 21.  GOVERNING LAW

21.                                 The validity and interpretation of this
Agreement and the legal relations of the parties to it shall be governed by the
laws of the Commonwealth of Massachusetts without regard to the conflict of laws
provisions thereunder.

ARTICLE 22.  CAPTIONS

22.                                 The captions are provided for convenience
and are not to be used in construing this Agreement.

ARTICLE 23.  CONSTRUCTION

23.                                 Each of the parties agree that this
Agreement is the result of mutual negotiation and therefore the language herein
shall not be presumptively construed against either of them.

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ARTICLE 24.  COUNTERPARTS

24.                                 This Agreement may be executed in one or
more counterparts, each of which shall be deemed to be an original, and all of
which together shall be deemed to be one and the same instrument.

ARTICLE 25.  BINDING EFFECT

25.                                 This Agreement shall be binding upon and
inure to the benefit of the parties and their respective permitted successors
and permitted assigns.

ARTICLE 26.  FORCE MAJEURE

26.                                 Neither party shall be deemed to be in
breach of this Agreement due to, or liable to the other party for damages or
loss occasioned by failure of performance by the defaulting party if the failure
is occasioned by war, fire, explosion, flood, acts of God, strike or lockout,
embargo, or any similar cause beyond the control of the defaulting party;
provided that the party claiming this exception has exerted all commercially
reasonable and diligent efforts to avoid or remedy such event and that such
event does not extend for more than nine (9) months; provided further that such
party provides the other party with prompt written notice of any delay or
failure to perform that occurs by reason of force majeure and continues
performance hereunder with reasonable dispatch whenever such causes are
removed.  The parties shall mutually seek a resolution of the delay or failure
to perform in good faith if a force majeure event extends for more than nine (9)
months, which resolution may be termination of this Agreement.

ARTICLE 27.  JHU LICENSE AGREEMENT

27.                                 In the event that Genzyme’s license to the
Patent Rights under the JHU License Agreement is terminated, this Agreement
shall remain in effect pursuant to the terms of the JHU License Agreement
provided that at such time EXACT is not in material breach of the provisions of
this Agreement and agrees to be bound to JHU as a licensor under the terms and
conditions of this Agreement.

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

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IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed
by their respective duly authorized representatives as of the date first above
written.

 

GENZYME CORPORATION

 

 

 

By:

/s/ Peter Wirth

 

 

 

 

Name: Peter Wirth

 

 

 

Title: Executive Vice President

 

 

 

Date: Mach 25, 1999

 

 

 

 

 

 

 

EXACT LABORATORIES, INC.

 

 

 

By:

/s/ Donna K. Hazard

 

 

 

 

Name: Donna K. Hazard

 

 

 

Title: VP, Business Development

 

 

 

Date: March 23, 1999

 

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Appendix A

Gene Patent Rights

U.S. Patent No. 5,352,775

 

 

 

AU9213669

Patent Application No. W092/13103

GB 91000962

US Patent No. 5,648,212 (Div. of `775)

GB 91000963

US Patent No. 5,691,454 (Div. of `775)

GB 91000974

US Patent No. 5,783,666 (Div. of `775)

GB 9100975

 

EP 569527

 

JP 7500241

 

 

 

U.S. Patent No. 5,527,676

 

 

 

EP 390323

 

JP 4004898

 

 

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Appendix B

Methodology Patent Rights

 

Patent Application No.  W093/20235 (detecting mammalian nucleic acids from
stool)

EP 672181

JP 8504081

U.S.  Patent Application No.  08/861,910

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