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EXHIBIT 10-12
Agreement

Between the following parties:

Regarding the work carried out and the results of that work (“the Results”)

NovAliX Deutschland GmbH (“NOVALIX”), a German corporation located at
 Seckenheimer Landstrasse 4, D-68163 Mannheim, Germany, represented by its
Geschäftsführer, Mr Stephan JENN. The (“COMPANY”), Gardedam Therapeutics, Inc.
(“GARDEDAM”), headquartered at 1597 Cross Way San Jose, CA 95125 USA, and any
acquiring, merging or successor companies, represented by its CEO, Dr. Gergely
TOTH, the (“FOUNDER”),  

The parties (1) - (2) are hereinafter also individually and collectively
referred to as “Party” or as "Parties".

DEFINITIONS.

“Patent Rights” shall mean any and all patent applications, provisional patent
applications and any patents issuing therefrom worldwide, together with any
extensions, registrations, confirmations, reissues, continuations, divisions,
continuations in-part, reexamination certificates, confirmations, registrations,
revalidations, additions, supplementary protection certificates, substitutions
or renewals thereof and any patents anywhere in the world, claiming the priority
date of any of the foregoing.

“NOVALIX Compound Patent Rights” shall mean any and all Patent Rights owned or
controlled by NOVALIX that claim or cover any chemical compound.

“Hit Series Compounds” shall mean selected series of compounds from the NOVALIX
chemical microarrays showing binding and SAR trends to the DJ-1 protein.

“NOVALIX Compound Technology” shall mean any and all Technology generated by
NOVALIX in the performance of the Collaboration and related to any Hit Series
compound.

 
EXHIBIT 10.12, 1

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“NOVALIX Synthesized Compounds” shall mean Hit Series compounds to be
synthesized by NOVALIX.

Whereas:
a.NOVALIX is the legal successor of Graffinity Pharmaceuticals GmbH
(“GRAFFINITY”), a former German corporation located at Im Neuenheimer Feld
518-519, 69120 Heidelberg, Germany, and has purchased all assets, IP, expertise
and proprietary rights relating to label-free chemical microarray technologies
that detect affinity interactions between compounds and targets and resulting
processes leading to new chemical entities.
b.According to a collaboration agreement (COLLABORATION CONTRACT) between
GARDEDAM and GRAFFINITY dated December 23, 2009, GRAFFINITY used its platform
technology, chemical microarray SPR HTS, to screen the DJ-1 protein to identify
a binding fingerprint and on the basis of this select series of compounds
potentially binding to the Target.  The results of this screen was reported and
communicated to GARDEDAM in a written electronic report entitled Fingerprint
Report (“COLLABORATION DATA”).
c.In consideration of the performance of the collaboration, generation and
communication of the Fingerprint Report by GRAFFINITY and the grant by NOVALIX
of Rights outlined in Clause 2 “Rights” to GARDEDAM hereunder, GARDEDAM should
pay to NOVALIX a non-refundable fee of Euro 112,000 (the “PAYMENT AMOUNT”).
d.Upon signing, the COLLABORATION CONTRACT will be set aside, along with any
unperformed actions under that contract, and this agreement will then constitute
the entire agreement and understanding between NOVALIX and GARDEDAM with regard
to the COLLABORATION CONTRACT. This Agreement shall supersede any prior
promises, agreements, representations, undertakings or implications whether made
orally or in writing between NOVALIX and GARDEDAM relating to the subject matter
of this agreement.

 

 
EXHIBIT 10.12, 2

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1.Payment schedule. The total PAYMENT AMOUNT of Euro €112,000 (one hundred and
twelve thousand Euros) will be paid in 3 (three) tranches (the “Payment
Tranches”), the first of which (the “First Tranche”), of Euro €30,000 (thirty
thousand Euros), is due in full within 30 days of the date hereof (the “Initial
Closing Date”), the second of which (the “Second Tranche”), of Euro €35,000
(thirty five thousand Euros), is due within 30 days of a date six (6) calendar
months after the Initial Closing Date, (the “Second Closing Date”) and the third
of which (the “Third Tranche”), of Euro €47,000 (forty seven thousand Euros), is
due within 30 days of a date six (6) months after the Second Closing Date (the
“Final Closing Date”).

2.Rights. NOVALIX hereby agrees to grant and hereby grants to GARDEDAM a
worldwide, perpetual, non-exclusive, license, with the right to sublicense,
under any NOVALIX Compound Patent Rights and NOVALIX Compound Technology to use
the Hit Series compounds, NOVALIX Synthesized Compounds (whether or not
synthesized by NOVALIX or by another person or entity), any other compounds
synthesized by NOVALIX for GARDEDAM against DJ-1, any other compounds delivered
by NOVALIX to GARDEDAM hereunder and any information disclosed in the
Fingerprint Report for any legal purpose, including without limitation to
patent, to make, have made, use, sell, re-sell and import and export products of
any kind whatsoever, including without limitation any and all products based on,
incorporating or comprised of, in whole or in part, any or all of the Hit Series
Compounds, NOVALIX Synthesized Compounds, and any other compounds synthesized by
NOVALIX for GARDEDAM against the DJ-1 protein, without further obligation to
NOVALIX.

3.Right of re-use. NOVALIX shall be free, without obligation to GARDEDAM, to
screen the same target as the Target, itself or for any third party, to identify
compounds that bind against such target, and to make, have made, use and sell
products; provided, however, that in no event shall NOVALIX use for any purpose
including, without limitation, its own interest or disclose to any third party
any data generated in the performance of this Collaboration, including without
limitation, the data in the Fingerprint Report, the hit series and all of the
COLLABORATION DATA.

 
EXHIBIT 10.12, 3

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4.Penalties. In the event of late payment as defined by 30 calendar days from
the Closing Date for each tranche (as detailed in clause 1) the amount
outstanding calculated as the initial PAYMENT AMOUNT minus any payments made in
the PAYMENT TRANCHES will be doubled. In the event of non-payment of any
outstanding balance of the PAYMENT AMOUNT 6 months after the final and Third
Closing Date all rights for the RESULTS are to be returned to NOVALIX.

5.Early repayment. Gardedam may, at its discretion:

 
a.Elect to complete payment of the First Tranche at any time on or prior to the
Initial Closing Date.

 
b.Elect to complete payment of the Second Tranche at any time on or prior to the
Second Closing Date.

 
c.Elect to complete payment of the Third Tranche at any time on or prior to the
Third Closing Date.

6.Governing Law. This Subscription Agreement is governed by the laws of United
Kingdom.  The Purchaser, in its personal or corporate capacity and, if
applicable, on behalf of each beneficial purchaser for whom it is acting,
irrevocably attorns to the jurisdiction of the courts of the city of London
(UK).

7.Counterparts and Electronic Means. This agreement may be executed in any
number of counterparts, each of which, when so executed and delivered, shall
constitute an original and all of which together shall constitute one
instrument.  Delivery of an executed copy of this Subscription Agreement by
electronic facsimile transmission or other means of electronic communication
capable of producing a printed copy will be deemed to be execution and delivery
of this Subscription Agreement as of the date hereinafter set forth.

 
EXHIBIT 10.12, 4

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IN WITNESS WHEREOF the NOVALIX has duly executed this Agreement
 
 
NovAliX
 
 
 
/s/ Stephan
Jenn                                                                              
Stephan Jenn, Geschäftsführer, NovAliX Deutschland GmbH
 

 
NovAliX Deutschland GmbH
 
Seckenheimer Landstrasse 4,
 
D-68163 Mannheim, Germany
 
 

 
 
A C C E P T A N C E
 
The above-mentioned Agreement is accepted by Gardedam Therapeutics, Inc.
 
DATED,  12st November, 2015.
 
 
GARDEDAM THERAPEUTICS, INC.
 

 
By: /s/ Gergely Toth                             
 
Signature and print name

                        Gergely Toth
 
           Chief Executive Officer

 
EXHIBIT 10.12, 5

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