Exhibit 10.168.1

 

Termination of Inducement Stock Option

 

Reference is made to that certain option to purchase 750,000 shares of Common
Stock of The Immune Response Corporation (the “Company”) that was granted to
Robert E. Knowling, Jr. (“Knowling”) pursuant to the Inducement Stock Option
Grant Notice dated February 9, 2005 (the “Option”).

 

The Company and Knowling agree that the Option is hereby terminated, effective
immediately.

 

Dated: June 22, 2005

 

 

The Immune Response Corporation

 

 

 

By:

/s/ Michael K. Green

 

 

 

Michael K. Green

 

 

Vice President, Finance and Chief Financial
Officer

 

 

 

 

 

/s/ Robert E. Knowling, Jr.

 

 

Robert E. Knowling, Jr.

 

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