Exhibit 10.43

April 2, 2007

Dr. JamesW. Mier

Division of Oncology

Beth Israel Deaconess Medical Center

Kirstein 158

330 Brookline Avenue

Boston, MA 02215

Re:  Agreement for Service on Senesco Technologies, Inc. Scientific Advisory
Board

Dear Dr. Mier:

This will confirm the terms of the agreement between you and Senesco
Technologies, Inc. (“SENESCO”) concerning your service on the SENESCO Scientific
Advisory Board.

You have agreed to serve on the SENESCO Scientific Advisory Board for a three
year term to begin on April 1, 2007 and end on March 31, 2010.  This agreement
may be terminated by either party with ninety (90) days written notice.  In this
capacity, you agree to provide consulting services relating to research and
development on genes and their cognate expressed proteins that are induced
during or coincident with the onset of cell death, which may initiate or
facilitate cell death, together with methods for controlling cell death that
involve altering the expression of these genes, along with all other SENESCO
technological developments (“Subject Matter of this Agreement”).  As a member of
the SENESCO Scientific Advisory Board, you agree to alert the company to
technology and research in the industry which is relevant to the Subject Matter
of this Agreement, and to act as a member of a forum for the exchange of new
ideas.  You agree to participate in conference calls, participate in brief
conference at your offices, and review materials forwarded to you by SENESCO
(the volume of time and materials shall be reasonable in light of your
position).  As compensation for your service, SENESCO agrees to pay you $10,000
per annum, payable in equal quarterly installments.  In addition, SENESCO will
reimburse you for reasonable out of pocket expenses incurred by you in
connection with your services hereunder.

As a condition of your service to SENESCO, you will agree to keep Confidential
Information of SENESCO in confidence:

a.               Confidential Information includes all information disclosed by
SENESCO to you whether said disclosure is made in writing, by submission of
samples,

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orally, or otherwise, relating to the matters which are within the scope and are
the subject of this Agreement and all other associated information regarding
SENESCO’s past, present, or future research, technology, know-how, ideas,
concepts, designs, products, prototypes, processes, machines, compositions of
matter, business plans, technical information, drawings, specifications and the
like, relating in each case to the Subject Matter of this Agreement and any
knowledge or information developed by you as a result of work in connection with
this Agreement; except information which, at the time of the disclosure to you
or development under this agreement:

(1)             is established by written records to be in the public domain
other than as a consequence of an act by you;

(2)             was in your possession prior to the disclosure and is
demonstrated  through written record that such information was in your
possession prior to disclosure from SENESCO, and was not the subject of an
earlier confidential relationship with SENESCO; or

(3)             was rightfully acquired by you from a third party, who was
lawfully in possession of such information after the disclosure and was under no
obligation to SENESCO to maintain its confidentiality.

b.              All Confidential Information of SENESCO disclosed to you shall
remain the sole property of SENESCO.  You agree that the Confidential
Information will be kept in strict confidence until such Confidential
Information becomes readily and conveniently available in the trade.  You agree
that you will not directly or indirectly disclose, furnish, disseminate, make
available or use the Confidential Information except as necessary to perform the
consulting services under the provision of this Agreement.  Your confidentiality
obligations hereunder will survive the termination of this agreement.

c.               While you serve on the SENESCO Scientific Advisory Board, you
will promptly inform SENESCO if you discover that a third party is making or
threatening to make unauthorized use of Confidential Information.

d.              You acknowledge that the agreements contained herein are of a
special nature and that any material breach of this Agreement by you will result
in irreparable harm or injury to SENESCO.

You represent and warrant that you have the full power to enter into and perform
this Agreement, and that you are under no obligation or restriction and will not
assume any obligation or restriction that would in any way be considered by a
reasonable person to interfere with, be inconsistent with, or present a conflict
of interest concerning your services in connection with this Agreement.

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During the period of this Agreement, you represent and warrant that you are not
rendering and will not render any other consulting services relating to the
Subject Matter of this Agreement.

You hereby assign and agree to assign to SENESCO all of your right, title and
interest in any inventions made, conceived of or arising as a result of your
performance of duties under this Agreement.  All information and know-how
relating to such inventions is also deemed Confidential Information of SENESCO
and shall be kept in confidence by you pursuant to this Agreement.  SENESCO has
control of all right, title and interest to any patent or patent application
drawn to such inventions conceived of or made during the performance of your
work under this Agreement.  You shall, at the reasonable request and expense of
SENESCO, at any time during or after the termination of this Agreement, execute
all documents and perform all such acts as SENESCO may deem necessary or
advisable to confirm SENESCO’s sole and exclusive ownership right, title and
interest in such inventions in any country.  You agree to do all acts and
execute all documents at the expense and request of SENESCO that SENESCO may
deem necessary to secure its rights to such inventions, including but not
limited to assisting in the preparation and prosecution of patent applications.

In view of the highly confidential nature of the services to be rendered by you
under this Agreement, you hereby agree that you will not, during the period of
this Agreement, act as a consultant, or perform any other services, either
directly or indirectly, for any entity in the world which is competitive with
SENESCO relating to the Subject Matter of this Agreement.  The parties hereby
agree that the period of time and scope of the restrictions specified herein are
both reasonable and justifiable to prevent harm to the legitimate business
interests of SENESCO, including but not limited to preventing transfer of
Confidential Information to SENESCO’s competitors and/or preventing other
unauthorized disclosures or use of SENESCO’s technology and inventions.

Yours Truly,

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Sascha P. Fedyszyn

Vice President, Corporate Development

SENESCO TECHNOLOGIES, INC.

Agreed:

 

 

 

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