Exhibit 10.1

 

 

Dated February 10, 2004

 

 

VERTEX PHARMACEUTICALS INCORPORATED
and
UBS SECURITIES LLC

 

 

DEALER MANAGER AGREEMENT

 

 

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UBS Securities LLC
677 Washington Boulevard
Stamford, CT  06901

 

Ladies and Gentlemen:

 

1                                         Exempted Exchanges

 

Vertex Pharmaceuticals Incorporated, a corporation organized under the laws of
Massachusetts (the “Company”), proposes to exchange with certain holders of its
5% Convertible Subordinated Notes due September 19, 2007 (the “Existing Notes”)
its 5¾% Convertible Senior Subordinated Notes due 2011 (the “New Notes”), to be
issued pursuant to the terms of an indenture to be entered into between the
Company and US Bank National Association (the “Trustee”), as trustee (the “New
Notes Indenture”) (such exchanges, including all related incidental acts and
transactions, are herein referred to collectively as “Exempted Exchanges”).  The
New Notes will be issued in book-entry form and will be issued to Cede & Co. as
nominee of The Depository Trust Company (“DTC”).  The New Notes will be
convertible into shares of common stock, par value $0.01 per share (the “Common
Stock”), of the Company at the conversion price set forth in the New Notes
Indenture.  The Exempted Exchanges will be made on the terms and subject to the
conditions set forth in the Company’s Offering Memorandum (including all
documents incorporated therein by reference, the “Offering Memorandum”) and the
related letter of transmittal (the “Letter of Transmittal”) attached hereto as
Exhibit A-1 and Exhibit A-2, respectively.

 

The Exempted Exchanges are expected to be commenced by the Company on or about
February 3, 2004 (the “Commencement Date”). In connection with the Exempted
exchanges, no more than six (6) holders of Existing Notes will be approached and
no more than $154.35 million principal amount of Existing Notes will be
exchanged for New Notes.  Holders of the New Notes will be entitled to the
benefits of a Registration Rights Agreement (the “Registration Rights
Agreement”), to be dated as of the Closing Date, pursuant to which the Company
will agree to register the resale of the New Notes under the U.S. Securities Act
of 1933, as amended (the “Securities Act”) subject to the terms and conditions
therein specified.

 

The Exempted Exchanges will be made without registration of the New Notes or the
Common Stock issuable upon conversion thereof under the Securities Act in
reliance upon exemptions from the registration requirements of the Securities
Act.

 

2              Appointment as Dealer Manager

 

The Company hereby engages and appoints UBS Securities LLC as sole and exclusive
dealer manager in connection with the Exempted Exchanges (the “Dealer Manager”)
and authorizes the Dealer Manager to act as such, and you hereby agree to act as
Dealer Manager, in each case on the terms and conditions set forth herein. On
the basis of the representations, warranties, agreements and covenants of the
Company in, and subject to the terms and conditions of, this Dealer Manager
Agreement (this “Agreement”), you agree, as Dealer Manager, to use your
commercially reasonable efforts to effect the Exempted Exchanges and perform
other services in connection with the Exempted

 

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Exchanges as are customarily performed by investment banks of international
standing acting in such roles in connection with exchange transactions of like
nature, including, but not limited to, assisting the Company with respect to the
timing, pricing and structure of the Exempted Exchanges, assisting the Company
in the preparation of the Offering Memorandum, identifying and contacting
certain holders of the Existing Notes with respect to the Exempted Exchanges and
participating in negotiations with such holders of the Existing Notes and
communicating generally regarding the Exempted Exchanges with brokers, dealers,
commercial banks and trust companies and other nominees or holders of the
Existing Notes, both of record and beneficial. The duties or responsibilities of
the Dealer Manager will not include: (i) providing tax, legal, regulatory,
accountancy or other specialist or technical advice or services, (ii) providing
general financial and strategic advice, or (iii) assuming any responsibility for
the verification of the information in the Offering Memorandum or any ancillary
documents other than the UBS Information (as defined in Section 8.21). In
effecting Exempted Exchanges and generally in connection with the Exempted
Exchanges, you, as Dealer Manager, are acting as an independent contractor and
shall not be deemed to be acting as the agent of the Company, and the Company
shall not be deemed to act as your agent.

 

3              No Liability for Acts of Dealers, Banks and Trust Companies

 

Neither you nor any of your affiliates, directors, agents, employees or
controlling persons shall have any liability (in tort, contract or otherwise) to
the Company or to any other person for any losses, claims, damages, liabilities
or expenses arising out of any act or omission on the part of any broker, dealer
(other than yourself to the extent set forth below), depositary, commercial bank
or trust company or any other person, and neither you nor any of your
affiliates, directors, agents, employees or controlling persons shall have any
liability (in tort, contract or otherwise) to the Company or any other person
asserting claims on behalf of or in right of the Company for any losses, claims,
damages, liabilities or expenses arising from your own acts or omissions in
performing your obligations hereunder or otherwise in connection with the
proposed Exempted Exchanges, except for any such losses, claims, damages,
liabilities or expenses which are determined, in a final judgment by a court of
competent jurisdiction, to have resulted from (i) your gross negligence or
willful misconduct in performing the services that are the subject of this
Agreement or (ii) a breach by the Dealer Manager of Section 9.20(ii).

 

4              The Offering Memorandum; Early Termination

 

4.1.                            The Company agrees to furnish you with as many
copies as you may reasonably request of the Offering Memorandum, any amendments
and supplements thereto and the related Letter of Transmittal (collectively, as
amended or supplemented from time to time, and in each and every case including
any and all information or documents incorporated therein by reference, the
“Exchange Materials”) to be used by the Company in connection with the Exempted
Exchanges. You are authorized to use copies of the Exchange Materials in
accordance with the terms and conditions of this Agreement. You and your
representatives may not forward written materials other than the Exchange
Materials or any publicly filed documents to the holders of the Existing Notes
in connection with the Exempted

 

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Exchange without the Company’s consent. The Company agrees that, at a reasonable
time prior to using or filing with any federal or other governmental agency or
instrumentality any Exchange Materials, it will first submit copies of such
materials to you and will not use any such Exchange Materials without your prior
approval, which shall not be unreasonably withheld. During the period from the
commencement of the Exempted Exchanges and the Closing Date, the Company will
inform you promptly after it receives notice or becomes aware of the happening
of any event, or the discovery of any fact, which it believes would require the
making of any material change in any Exchange Materials then being used or would
affect the truth, accuracy or completeness of any representation or warranty
contained in this Agreement as if such representation or warranty were being
made immediately after the happening of such event or the discovery of such
fact.

 

4.2.                            In the event that (i) the Company uses or
permits the use of any document in connection with the Exempted Exchanges which
you shall not have approved or (ii) the Company shall have breached, in any
material respect, any of its representations, warranties, agreements or
covenants herein, then you shall be entitled to withdraw as Dealer Manager in
connection with the Exempted Exchanges without any liability or penalty to you
or any other party who may be indemnified pursuant to the terms of Section 10
hereof (it being agreed that such withdrawal shall not affect the indemnity
provisions contained in Section 10 hereof, which shall remain in full force and
effect) and without loss of any right to the payment of all expenses payable
hereunder which have been incurred to the date of such withdrawal.
Notwithstanding anything to the contrary contained herein, it is hereby agreed
that, in the event of any withdrawal by you pursuant to this Section 4.2, the
expenses, if any, payable hereunder which are reasonably incurred through the
date of such withdrawal shall be paid or reimbursed to you reasonably promptly
after the date of such withdrawal.

 

5              Consideration

 

As consideration for your services as dealer manager hereunder, the Company
shall pay to you in cash, by wire transfer of immediately available funds to an
account designated therefor by you, a fee equal 1.50% of the principal amount of
the Existing Notes exchanged by the Company (the Dealer Manager’s fee shall be
referred to in this Agreement as the “Fee”).

 

The Fee shall be payable in full on the date of the successful completion of the
Exempted Exchanges.  The date of the successful completion of the Exempted
Exchanges is hereby referred to as the “Closing Date”.

 

6                                         Expenses of Dealer Manager and Others

 

The Company shall pay all fees and expenses relating to the preparation,
printing, mailing and publishing of the Exchange Materials.  The Company will
also reimburse you for all reasonable fees and expenses (including the
reasonable fees and expenses of

 

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your counsel) incurred by you in connection with the performance of your
services as Dealer Manager under this Agreement.  The Company shall perform its
obligations set forth in this Section 6 and Section 10 hereof whether or not the
Exempted Exchanges are commenced, except in the event that the Exempted
Exchanges are withdrawn, terminated or cancelled, in which case the Company’s
obligations to pay such expenses shall extend only to expenses accrued as of the
date of such withdrawal, termination or cancellation. All payments to be made by
the Company pursuant to this Section 6 shall be made reasonably promptly after
the expiration, completion, termination, withdrawal or cancellation of the
Exempted Exchanges.

 

7                                         Noteholder Lists

 

The Company shall, to the extent available to the Company after having made
commercially reasonable efforts to obtain, provide you with lists or other
records in such form as you may reasonably request in reasonable quantities or
copies thereof showing the names and addresses of, and principal amounts of
Existing Notes held by, the holders of Existing Notes, and will use its
commercially reasonable efforts to advise you or cause the Trustee and DTC to
advise you from day to day during the period between the Commencement Date and
the Closing Date as to any transfers of record of Existing Notes. You agree to
use such information only in connection with the Exempted Exchanges and, unless
such information becomes publicly available (other than by breach by the Dealer
Manager of the following undertaking), not to furnish such information to any
other person except in connection with the Exempted Exchanges or as required by
law or upon request of any governmental or regulatory agency or any securities
exchange having jurisdiction with respect to the Dealer Manager or the Exempted
Exchanges.

 

8                                         Representations and Warranties of the
Company

 

The Company represents and warrants to you, and agrees with you, where
applicable, that:

 

8.1.                            the Company has been duly organized, is validly
existing as a corporation under the laws of Massachusetts and has the corporate
power and authority to own its property and to conduct its business as described
in the Exchange Materials and is duly qualified in or licensed by, and is in
good standing (or other similar concept that may exist in the applicable
jurisdiction) in, each jurisdiction in which the nature of its business requires
such qualification, except where the failure, individually or in the aggregate,
to be so licensed or qualified could not reasonably be expected to have a
material adverse effect on the business, operations, prospects, properties or
condition (financial or otherwise) or results of operations of the Company and
its subsidiaries, taken as a whole (a “Material Adverse Effect”); each of the
subsidiaries of the Company has been duly organized or formed, is validly
existing as a corporation, limited liability company or limited partnership, as
the case may be, in good standing, if applicable, under the laws of the
jurisdiction in which it is chartered or  organized, and is duly qualified in or
licensed by, and is in good standing (or, if applicable, other similar concept
that may exist in the applicable jurisdiction) in, each

 

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jurisdiction in which the nature of its business requires such qualification,
except where the failure, individually or in the aggregate, to be so licensed or
qualified could reasonably be expected to have a Material Adverse Effect;

 

8.2.                            none of the Company, its affiliates, or any
person acting on its or their behalf (other than the Dealer Manager or persons
acting on its behalf, as to whom the Company makes no representation) has,
directly or indirectly, made offers or sales of any security, or solicited
offers to buy, any security under circumstances that would require the
registration of the New Notes or the Common Stock issuable upon conversion
thereof under the Securities Act;

 

8.3.                            none of the Company, its affiliates, or any
person acting on its or their behalf (other than the Dealer Manager or persons
acting on its behalf, as to whom the Company makes no representation) has
engaged in any form of general solicitation or general advertising (within the
meaning of Regulation D) in connection with the Exempted Exchanges with respect
to the New Notes or the Common Stock issuable upon conversion thereof;

 

8.4.                            the New Notes satisfy the eligibility
requirements of Rule 144A(d)(3) under the Securities Act;

 

8.5.                            the Company has been advised by the NASD’s
PORTAL Market that the New Notes have been designated PORTAL-eligible securities
in accordance with the rules and regulations of the NASD;

 

8.6.                            subject to compliance by the Dealer Manager with
the representations and warranties sets forth in Section 9.20 hereof, no
registration under the Securities Act of the New Notes is required in connection
with the Exempted Exchanges in the manner contemplated herein and in the
Offering Memorandum;

 

8.7.                            [Intentionally omitted].

 

8.8.                            the Company has not paid or agreed to pay to any
person any compensation for soliciting another to purchase or sell any
securities of the Company (except as contemplated in this Agreement);

 

8.9.                            the Company has not taken, directly or
indirectly, any action designed to or that has constituted or that might
reasonably be expected to cause or result, under the U.S. Securities Exchange
Act of 1934, as amended (the “1934 Act”) or otherwise, in stabilization or
manipulation of the price of any security of the Company to facilitate the
Exempted Exchanges;

 

8.10.                     all the outstanding shares of capital stock or other
applicable ownership interests of each subsidiary have been duly authorized and
validly issued and are fully paid and nonassessable and, except as otherwise set
forth in the Offering Memorandum, all outstanding shares of capital stock or
other applicable ownership interests of the subsidiaries are owned by the
Company either directly or through wholly owned subsidiaries free and clear of
any security interest, claim, lien or encumbrance;

 

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8.11.                     the Company’s authorized equity capitalization is as
set forth in the Exchange Materials; the capital stock of the Company conforms
in all material respects to the description thereof contained in the Offering
Memorandum; the outstanding shares of Common Stock have been duly authorized and
validly issued and are fully paid and nonassessable; the shares of Common Stock
initially issuable upon conversion of the New Notes have been duly authorized
and, when issued upon conversion of the New Notes against payment of the
conversion price, will be validly issued, fully paid and nonassessable; the
Board of Directors of the Company has duly and validly adopted resolutions
reserving such shares of Common Stock for issuance upon conversion of the New
Notes; the holders of outstanding shares of capital stock of the Company are not
entitled to preemptive or other rights to subscribe for the New Notes or the
shares of Common Stock issuable upon conversion thereof; and, except as set
forth in or contemplated by the Offering Memorandum, no options, warrants or
other rights to purchase, agreements or other obligations to issue, or rights to
convert any obligations into or exchange any securities for, shares of capital
stock of or ownership interests in the Company are outstanding;

 

8.12.                     the statements in the Offering Memorandum under the
headings “Certain U.S. Federal Income Tax Consequences”, “The Exempted
Exchanges”, “Description of the New Notes” and “Description of Common Stock”
fairly summarize the matters therein described;

 

8.13.                     all necessary action (corporate and other) has been
duly taken by the Company to authorize the execution, delivery and performance
of this Agreement, the Company has all requisite power and authority to
consummate the transactions contemplated hereby, and this Agreement has been
duly executed and delivered by the Company and is a legal, valid and binding
obligation of the Company enforceable against the Company in accordance with its
terms, except, in each case, as rights to indemnification and contribution
hereunder may be limited by public policy considerations and except as
enforcement thereof may be limited by or subject to (x) any bankruptcy,
insolvency, reorganization, fraudulent conveyance, fraudulent transfer,
moratorium or other similar laws affecting the enforcement of creditors’ rights
generally, and (y) general equitable principles or the availability of equitable
remedies;

 

8.14.                     all necessary action (corporate and other) has been
duly taken by the Company to authorize the Exempted Exchanges, the execution,
delivery and performance of the New Notes Indenture and the execution, delivery
and performance of the Registration Rights Agreement, the Company has all
requisite power and authority to consummate the transactions contemplated
thereby, and each of the New Notes Indenture and Registration Rights Agreement,
when executed and delivered by the Company (and, in the case of the New Notes
Indenture, on the date that the Existing Notes are exchanged for the New Notes),
will be a legal, valid and binding obligation of the Company enforceable against
the Company in accordance with its terms, except, in the case of the
Registration Rights Agreement, as rights to indemnification and contribution
thereunder may be

 

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limited by public policy considerations and except, in each case, as enforcement
thereof may be limited by or subject to (x) any bankruptcy, insolvency,
reorganization, fraudulent conveyance, fraudulent transfer, moratorium or other
similar laws affecting the enforcement of creditors’ rights generally, and (y)
general equitable principles or the availability of equitable remedies;

 

8.15.                     the New Notes have been duly authorized and, when
executed and authenticated and delivered in accordance with the provisions of
the New Notes Indenture, will be entitled to the benefits of the New Notes
Indenture, and will be valid and binding obligations of the Company, enforceable
against the Company in accordance with its terms, except as enforcement thereof
may be limited by or subject to (x) any bankruptcy, insolvency, reorganization,
fraudulent conveyance, fraudulent transfer, moratorium or other similar laws
affecting the enforcement of creditors’ rights generally, and (y) general
equitable principles or the availability of equitable remedies;

 

8.16.                     no consent, approval, authorization, filing with or
order of any court or governmental agency or body is required in connection with
the Exempted Exchanges and the transactions contemplated herein, in the New
Notes Indenture or in the Registration Rights Agreement, except such as may be
required under the blue sky laws of any jurisdiction in which the Exempted
Exchanges occurs and, in the case of the Registration Rights Agreement, such as
will be obtained under the Securities Act, the U.S. Trust Indenture Act of 1939,
as amended (the “Trust Indenture Act”) and pursuant to the rules of the Nasdaq
National Market;

 

8.17.                     the Exempted Exchanges and all other actions of the
Company contemplated in the Exchange Materials and the execution, delivery and
performance of this Agreement, the New Notes Indenture and the Registration
Rights Agreement will comply in all material respects with (i) all applicable
requirements of law, including, without limitation, applicable regulations of
the U. S. Securities and Exchange Commission (the “Commission”) and (ii) all
other governmental, regulatory, administrative, stock exchange or similar
authority having jurisdiction over the Company and its subsidiaries or its
respective businesses, operations or assets;

 

8.18.                     except as disclosed in the Offering Memorandum
(exclusive of any amendment or supplement thereto), there are no actions, suits,
stop orders, restraining orders, claims, investigations or proceedings pending
or, to the best knowledge of the Company, threatened, before any court or
governmental agency or other regulatory or administrative authority or any
arbitrator, to which the Company or any of its subsidiaries is a party or to
which the Company, any of its subsidiaries or any of their licenses, concessions
or other properties and assets is subject, that, individually or in the
aggregate, could reasonably be expected to have a Material Adverse Effect; and
no actions, suits, claims, investigations or proceedings pending or, to the
knowledge of the Company, threatened, before any court or governmental agency or
other regulatory or administrative authority challenging or could otherwise be
reasonably expected to have a material adverse effect on the

 

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making of the Exempted Exchanges or any other transactions contemplated herein;

 

8.19.                     neither the Company, nor any of its subsidiaries, is
in breach of, or in default under (nor has any event occurred which with notice,
lapse of time or both would constitute a breach of, or default by the Company or
any of its subsidiaries under), (A) any provision of the charter or bylaws (or
similar organizational documents) of the Company or any of its subsidiaries or
(B) except as could not reasonably be expected to individually or in the
aggregate have a Material Adverse Effect, the terms of any indenture, contract,
lease, mortgage, deed of trust, note agreement, loan agreement or other
agreement, obligation, condition, covenant or instrument to which the Company or
any of its subsidiaries is a party or bound or to which its or their property is
subject, or under any federal, state, local or foreign law, regulation or rule
or any decree, judgment or order applicable to the Company or any of its
subsidiaries or any of its or their property; the Exempted Exchanges, all other
actions of the Company contemplated in the Exchange Materials, the execution,
delivery and performance of this Agreement, the New Notes Indenture and the
Registration Rights Agreement will not conflict with, or result in any breach of
or constitute a default under (nor constitute any event which with notice, lapse
of time or both would constitute a breach of, or default by the Company or any
of its subsidiaries under), (X) any provision of the charter or bylaws of the
Company or any of its subsidiaries, (Y) any provision of the Existing Notes
Indenture pursuant to which the Existing Notes were issued (in each case, as
supplemented or amended from time to time) and any agreements entered into by
the Company for the benefit of the holders of the Existing Notes, or (Z) without
prejudice to the foregoing, and except as could not reasonably be expected to
individually or in the aggregate have a Material Adverse Effect, the terms of
any indenture, contract, lease, mortgage, deed of trust, note agreement, loan
agreement or other agreement, obligation, condition, covenant or instrument to
which the Company or any of its subsidiaries is a party or bound or to which its
or their property is subject;

 

8.20.                     the terms of the New Notes, the New Notes Indenture
and the Registration Rights Agreement will conform in all material respects to
the descriptions thereof contained in the Offering Memorandum;

 

8.21.                     the Exchange Materials do not contain and, as amended
or supplemented, if applicable, will not contain any untrue statement of a
material fact or omit to state a material fact required to be stated therein or
necessary to make the statements made therein, in the light of the circumstances
under which they are made, not misleading; provided, however, that no
representation is made with respect to any statements contained in, or any
matter omitted from, the Exchange Materials in reliance upon and in conformity
with information relating to UBS Securities LLC furnished by you in writing to
the Company expressly for use therein, which information consists solely of the
name of the entity listed as the Dealer Manager on the cover of the Offering
Memorandum and the third sentence of the first

 

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paragraph under the heading “The exempted exchanges-New notes are a new issue of
securities” in the Offering Memorandum (the “UBS Information”);

 

8.22.                     as of the date hereof and at all times subsequent
hereto up to the Closing Date, the Company is subject to the reporting
requirements of Section 13 or Section 15(d) of the 1934 Act and has complied and
will continue to comply, in all material respects, with the 1934 Act, and the
rules and regulations thereunder, the Trust Indenture Act, and the rules and
regulations thereunder, and the various state securities or “blue sky” laws and
the applicable laws, rules and regulations of each jurisdiction in which any of
the Existing Notes are listed and any authority therein, in connection with the
Exempted Exchanges;

 

8.23.                     since the respective dates as of which information is
given in the Exchange Materials, there has not been any material change in the
business, operations, prospects, properties or condition (financial or
otherwise) or results of operations of the Company and its subsidiaries, taken
as a whole, whether or not arising in the ordinary course of business;

 

8.24.                     all documents incorporated by reference into the
Exchange Materials or from which information is so incorporated by reference,
when they were filed with or submitted to the Commission, complied in all
material respects with the requirements of the 1934 Act and the rules and
regulations promulgated thereunder; and any documents so filed or submitted and
incorporated by reference subsequent to the date of this Agreement and prior to
or on the Closing Date, when they are filed with or submitted to the Commission,
shall conform in all material respects with the requirements of the 1934 Act and
the rules and regulations thereunder;

 

8.25.                     the financial statements and related schedules and
notes thereto of the Company set forth or incorporated by reference in the
Exchange Materials present fairly in all material respects the consolidated
financial position of the Company and its consolidated subsidiaries as of the
dates indicated and the results of operations and cash flows of the Company and
its consolidated subsidiaries for the periods specified; such financial
statements have been prepared in conformity with generally accepted accounting
principles in the United States; all other financial data set forth in the
Exchange Materials are fairly presented in all material respects and prepared on
a basis consistent with the financial statements contained in the Exchange
Materials or incorporated by reference and the books and records of the Company
and its subsidiaries; and the assumptions used in preparing the pro forma
financial information included in the Exchange Materials provide a reasonable
basis for presenting the significant effects directly attributable to the
transactions or events described therein, the related pro forma adjustments give
appropriate effect to those assumptions, and the pro forma columns therein
reflect the proper application of those adjustments to the corresponding
historical financial statement amounts;

 

8.26.                     each of PricewaterhouseCoopers LLP and Ernst & Young
LLP, which has certified the financial statements of the Company and its
subsidiaries, are

 

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independent accountants, within the meaning of the Securities Act and the rules
and regulations thereunder;

 

8.27.                     there are no stamp or other issuance or transfer taxes
or duties or other similar fees or charges required to be paid in connection
with the execution and delivery of this Agreement or the consummation of the
Exempted Exchanges or upon the issuance of Common Stock upon the conversion of
the New Notes;

 

8.28.                     the Company has filed all non-U.S., U.S. federal,
state and local tax returns that are required to be filed or has requested
extensions thereof (except in any case in which the failure so to file could not
reasonably be expected to have a Material Adverse Effect and except as set forth
in or contemplated in the Offering Memorandum (exclusive of any amendment or
supplement thereto)) and has paid all taxes required to be paid by it and any
other assessment, fine or penalty levied against it, to the extent that any of
the foregoing is due and payable, except for any such tax, assessment, fine or
penalty that is currently being contested in good faith or as could not
reasonably be expected to have a Material Adverse Effect and except as set forth
in or contemplated in the Offering Memorandum (exclusive of any amendment or
supplement thereto);

 

8.29.                     no labor problem or dispute with the employees of the
Company or any of its subsidiaries exists or, to the Company’s knowledge, is
threatened, imminent or pending, except as set forth in or contemplated in the
Offering Memorandum (exclusive of any amendment or supplement thereto);

 

8.30.                     the Company and each of its subsidiaries are insured
by insurers of recognized financial responsibility against such losses and risks
and in such amounts as are prudent and customary in the businesses in which they
are engaged; all policies of insurance and fidelity or surety bonds insuring the
Company or any of its subsidiaries or their respective businesses, assets,
employees, officers and directors are in full force and effect; the Company and
its subsidiaries are in compliance with the terms of such policies and
instruments; except with respect to the pending securities class actions, there
are no claims by the Company or any of its subsidiaries under any such policy or
instrument as to which any insurance company is denying liability or defending
under a reservation of rights clause; neither the Company nor any of its
subsidiaries has any reason to believe that it will not be able to renew its
existing insurance coverage as and when such coverage expires or to obtain
similar coverage from similar insurers as may be necessary to continue its
business at a cost that could not reasonably be expected to have a Material
Adverse Effect except as set forth in or contemplated in the Offering Memorandum
(exclusive of any amendment or supplement thereto);

 

8.31.                     No subsidiary of the Company is currently prohibited,
directly or indirectly, from paying any dividends to the Company, from making
any other distribution on such subsidiary’s capital stock, from repaying to the
Company any loans or advances to such subsidiary from the Company or from
transferring any of such subsidiary’s property or assets to the Company or any
other subsidiary of the

 

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Company, except as described in or contemplated in the Offering Memorandum
(exclusive of any amendment or supplement thereto;

 

8.32.                     the Company and its subsidiaries possess all licenses,
certificates, permits and other authorizations issued by the appropriate U.S.
federal, state or non-U.S. regulatory authorities necessary to conduct their
respective businesses, except where the failure to possess such licenses,
certificates, permits and authorizations, individually or in the aggregate,
could not reasonably be expected to have a Material Adverse Effect and neither
the Company nor any of its subsidiaries has received any notice of proceedings
relating to the revocation or modification of any such certificate,
authorization or permit which, singly or in the aggregate, if the subject of an
unfavorable decision, ruling or finding, could reasonably be expected to have a
Material Adverse Effect, except as set forth in or contemplated in the Offering
Memorandum (exclusive of any amendment or supplement thereto);

 

8.33.                     except for matters governed by Environmental Laws
which are addressed in Sections 8.41 and 8.42, and except as disclosed in the
Offering Memorandum (exclusive of any amendment or supplement thereto), the
Company and each of its subsidiaries is in compliance with all applicable laws,
statutes, ordinances, rules and regulations of the Federal Food and Drug
Administration (the “FDA”) and OSHA, and has filed all applications and has
obtained all licenses, permits and approvals or other regulatory authorizations
of the FDA and OSHA (including, without limitation, all FDA approvals necessary
for marketing the products the Company and each of its subsidiaries currently
markets), the enforcement of which, individually or in the aggregate, could
reasonably be expected to have a Material Adverse Effect;

 

8.34.                     except for matters governed by Environmental Laws
which are addressed in Sections 8.41 and 8.42, and except as disclosed in the
Offering Memorandum (exclusive of any amendment or supplement thereto), the FDA
has not commenced, or, to the best of the Company’s knowledge, threatened to
initiate, any action to withdraw its approval of any product of the Company or
its subsidiaries or commenced or, to the best of the Company’s knowledge,
threatened to initiate any action to withdraw its approval of any facility of
the Company or its subsidiaries;

 

8.35.                     the Company and each of its subsidiaries maintain a
system of internal accounting controls sufficient to provide reasonable
assurance that (i) transactions are executed in accordance with management’s
general or specific authorizations; (ii) transactions are recorded as necessary
to permit preparation of financial statements in conformity with generally
accepted accounting principles and to maintain asset accountability; (iii)
access to assets is permitted only in accordance with management’s general or
specific authorization; and (iv) the recorded accountability for assets is
compared with the existing assets at reasonable intervals and appropriate action
is taken with respect to any differences;

 

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8.36.                     the Company has not taken any action or omitted to
take any action (such as issuing any press release relating to any New Notes
without an appropriate legend) which may result in the loss by the Dealer
Manager of the ability to rely on any stabilization safe harbor provided by the
Financial Services Authority under the Financial Services and Markets Act 2000
(the “FSMA”). The Company has been informed of the guidance relating to
stabilization provided by the Financial Services Authority, in particular in
Section MAR 2 Annex 2G of the Financial Services Handbook;

 

8.37.                     none of the Company, its subsidiaries or, to the
knowledge of the Company, any director, officer, agent, employee or Affiliate of
the Company or any of its subsidiaries is aware of or has taken any action,
directly or indirectly, that would result in a violation by such Persons of
Foreign Corrupt Practices Act of 1977, as amended, and the rules and regulations
thereunder (the “FCPA”), including, without limitation, making use of the mails
or any means or instrumentality of interstate commerce corruptly in furtherance
of an offer, payment, promise to pay or authorization of the payment of any
money, or other property, gift, promise to give, or authorization of the giving
of anything of value to any “foreign official” (as such term is defined in the
FCPA) or any foreign political party or official thereof or any candidate for
foreign political office, in contravention of the FCPA; and the Company, its
subsidiaries and, to the knowledge of the Company, its Affiliates have conducted
their businesses in compliance with the FCPA and have instituted and maintain
policies and procedures designed to ensure, and which are reasonably expected to
continue to ensure, continued compliance therewith;

 

8.38.                     subsequent to the respective dates as of which
information is given in the Offering Memorandum (exclusive of any amendment or
supplement thereto), neither the Company nor any of its subsidiaries has
sustained any material loss or interference with its business from fire,
explosion, flood or other calamity, whether or not covered by insurance, or from
any labor dispute or court or governmental action, order or decree, in each
case, that has had, or could reasonably be expected to have, a Material Adverse
Effect;

 

8.39.                     each of the Company and its subsidiaries, owns or
possesses, or can acquire on reasonable terms, adequate patents, patent
licenses, trademarks, service marks, trade names, know-how and other
intellectual property necessary to carry on its businesses as presently
conducted, and except as described in the Exchange Materials, neither the
Company nor any of its subsidiaries has received any notice of infringement of
or conflict with asserted rights of others with respect to any patents, patent
licenses, trademarks, service marks, trade names, know-how or other intellectual
property that in the aggregate could reasonably be expected to have a Material
Adverse Effect; the patent applications filed by or on behalf of the Company
described in the Exchange Materials have been properly prepared and filed on
behalf of the Company; each such patent applications and patents described in
the Exchange Materials is, except as set forth or contemplated in the Exchange
Materials, assigned or licensed to the Company, and, except as set forth in the
Exchange Materials, to the Company’s knowledge, no other entity or

 

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individual has any right or claim in any such patent, patent application or ay
patent to be issued therefrom; and to the knowledge of the Company, each such
patent application discloses potentially patentable subject matter;

 

8.40.                     to the best of the Company’s knowledge, the human
clinical trials conducted by the Company, on behalf of the Company or in which
the Company has participated that are described in the Exchange Materials, or
the results of which are referred to in the Exchange Materials, were and, if
still pending, are being, conducted in accordance with applicable regulatory
requirements; to the best of the Company’s knowledge, the descriptions of the
results of such studies, tests and trials contained in the Exchange Materials
are accurate in all material respects; the Company has no knowledge of any other
studies or tests conducted by the Company, on behalf of the Company or in which
the Company has participated, the results of which discredit the results
described in the Exchange Materials; the Company has not received any notice or
correspondence from the FDA or any other governmental agency requiring the
termination or suspension of any clinical trials conducted by, or on behalf of,
the Company or in which the Company has participated that are described in the
Exchange Materials or the results of which are referred to in the Exchange
Materials;

 

8.41.                     the Company and its subsidiaries (i) are in compliance
with any and all applicable federal, state, local and foreign laws and
regulations relating to the protection of human health and safety, the
environment or hazardous or toxic substances or wastes, pollutants or
contaminants (“Environmental Laws”), (ii) have received all permits, licenses or
other approvals required of them under applicable Environmental Laws to conduct
their respective businesses and (iii) are in compliance with all terms and
conditions of any such permit, license or approval, except where such
noncompliance with Environmental Laws, failure to receive required permits,
licenses or other approvals or failure to comply with the terms and conditions
of such permits, licenses or approvals could not, singly or in the aggregate,
reasonably be expected to have a Material Adverse Effect;

 

8.42.                     there are no pending or, to the best of the Company’s
knowledge, threatened, administrative, regulatory or judicial actions, suits,
demand letters, claims, liens, written notices of noncompliance or violation,
investigations or proceedings pursuant to any Environmental Laws against the
Company or any of its subsidiaries which would, singly or in the aggregate,
reasonably be expected to have a Material Adverse Effect; and, to the best of
the Company’s knowledge, there are no events or circumstances at the Company’s
owned or leased properties that could reasonably be expected to form the basis
of a governmental order for clean-up or remediation of hazardous or toxic
substances, wastes, pollutants or contaminants regulated under Environmental
Laws, or an action, suit or proceeding by any private party or governmental body
or agency, against the Company or any of its subsidiaries pursuant to
Environmental Laws; and

 

8.43.                     the Company is not, and after giving effect to the
Exempted Exchanges and the other transactions contemplated hereby, will not be,
an “investment company” as such term is defined in the U.S. Investment Company
Act of 1940, as amended.

 

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9                                         Covenants

 

9.1.                            Prior to and during the period up to the Closing
Date, the Company shall advise you promptly of (i) the occurrence of any event
or the discovery of any fact which is likely to cause or which causes the
Company to fail to commence, withdraw, rescind or terminate the Exempted
Exchanges or would reasonably be expected to permit the Company to exercise any
right not to accept the Existing Notes to be exchanged thereunder, (ii) any
proposal or requirement to modify, amend or supplement any of the Exchange
Materials, (iii) the commencement or threat in writing of any lawsuit or
government proceeding in connection with the Exempted Exchanges and (iv) any
other information relating to the Exempted Exchanges which you may from time to
time reasonably request.

 

9.2.                            The Company and you each agree to keep the other
reasonably informed as to the progress of the Exempted Exchange during the
period between the Commencement Date and the Closing Date, including providing
information as to the number and amount of Existing Notes that have agreed to be
exchanged.

 

9.3.                            The Company covenants that the Exempted
Exchanges and all other actions of the Company contemplated in the Exchange
Materials and this Agreement will comply in all material respects with all
applicable requirements of law, including, without limitation, the 1934 Act and
the rules and regulations thereunder (other than broker-dealer regulations), and
the various state securities or “blue sky” laws and the applicable listing laws,
rules and regulations of each jurisdiction in which any of the Existing Notes
are listed.

 

9.4.                            At all times subsequent to the date hereof up to
the Closing Date, the Exchange Materials, including any information and
documents incorporated by reference therein, will comply in all material
respects with all applicable requirements of law, including, without limitation,
the 1934 Act, and the Exchange Materials (as amended or supplemented from time
to time), including any information and documents incorporated by reference
therein, will not contain any untrue statement of a material fact or omit to
state a material fact required to be stated therein or necessary to make the
statements made therein, in the light of the circumstances under which they were
made, not misleading; provided that this covenant shall not extend to any
statements contained in, or any matter omitted from, the Exchange Offer
Materials in reliance upon and conformity with the UBS Information; provided,
further, that notwithstanding the foregoing, if at any time during the period
beginning the date hereof and the Closing Date, any event shall occur or
condition shall exist as a result of which the Exchange Materials, including any
information and documents incorporated by reference therein, will not comply in
all material respects with all applicable requirements of law, or such Exchange
Materials (as amended or supplemented from time to time), including any
information and documents incorporated by reference therein, will contain any
untrue statement of a material fact or omit to state a material fact required to
be stated therein or necessary to make the statements made therein, in the light
of the circumstances under which they were made, not misleading, then

 

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the Company shall either (i) promptly prepare such amendment or supplement to
the Exchange Materials, or any filing with or submission to the Commission with
respect to any such information or document incorporated by reference therein,
as may be necessary in order to correct such false or misleading statement or
omission, and take such action to make the Exchange Materials, including any
information or document incorporated by reference therein, comply with the
requirements of law, and distribute such amendment or supplement to holders of
Existing Notes involved in the Exempted Exchanges if it shall be necessary or
desirable to so distribute such amendment or supplement to comply with the
requirements of law, and provide such number of copies of such amendment or
supplement as the Dealer Manager shall request, or (ii) withdraw from, cancel,
rescind or otherwise terminate the Exempted Exchanges.

 

9.5.                            The Company agrees that a reasonable time prior
to using or permitting the use of the Exchange Materials in connection with the
Exempted Exchanges and to filing or submitting any document with the Commission
incorporated by reference therein, it shall submit copies of such documents to
the Dealer Manager and shall give reasonable consideration to the Dealer
Manager’s comments and those of the Dealer Manager’s counsel with respect
thereto.

 

9.6.                            The Company agrees that, except as required by
applicable law, any reference to the Dealer Manager in any Exchange Materials or
any other document or communication prepared, approved or authorized by the
Company in connection with the Exempted Exchanges is subject to the prior
approval of the Dealer Manager, provided that if such reference to the Dealer
Manager is required by applicable law, the Company agrees to notify the Dealer
Manager within a reasonable time prior to such use.

 

9.7.                            The Company will pay the Fee to the Dealer
Manager for soliciting, on the Company’s behalf, holders to enter into the
Exempted Exchanges and will provide each such holder with copies of the Offering
Memorandum, the Letter of Transmittal and any other Exchange Materials.

 

9.8.                            Neither the Company, nor any subsidiary or
affiliate thereof shall publicly disclose or refer to any advice rendered by the
Dealer Manager to the Company without the Dealer Manager’s prior written
consent, except as may be required by law, regulation, legal process or
regulatory authority and in any action, suit or proceeding to which the Company
is a party involving the Exempted Exchanges; provided, that, the Company shall
provide the Dealer Manager with prompt written notice, at the Dealer Manager’s
address for notice set forth in Section 16 hereto, of any such requirement so
that the Dealer Manager may seek a protection order or any other appropriate
remedy.

 

9.9.                            As soon as practicable before the Commencement
Date, the Company will make appropriate arrangements, to the extent applicable,
with DTC to allow for the book-entry movement of the exchanged Existing Notes
between DTC participants and the Dealer Manager, and will use its reasonable
best efforts to permit the New Notes to be eligible for clearance and settlement
through DTC.

 

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9.10.                     The Company will not, and will not permit any of its
affiliates to, resell any New Notes or Shares of Common Stock issued upon
conversion thereof that have been acquired by any of them.

 

9.11.                     None of the Company, its affiliates, or any person
acting on its or their behalf will, directly or indirectly, make offers or sales
of any security, or solicit offers to buy any security, under circumstances that
would require the registration of the New Notes or Common Stock issuable upon
conversion thereof under the Securities Act.

 

9.12.                     So long as any of the New Notes or the Common Stock
issuable upon the conversion thereof are “restricted securities” within the
meaning of Rule 144(a)(3) under the Securities Act, the Company, or any
successor thereto, will, during any period in which it is not subject to and in
compliance with Section 13 or 15(d) of the 1934 Act, provide to each holder of
such restricted securities and to each prospective purchaser (as designated by
such holder) of such restricted securities, upon the request of such holder or
prospective purchaser, any information required to be provided by Rule
144A(d)(4) under the Securities Act.  This covenant is intended to be for the
benefit of the holders, and the prospective purchasers designated by such
holders, from time to time of such restricted securities.

 

9.13.                     Any information provided by the Company to publishers
of publicly available databases about the terms of the New Notes shall include a
statement that the New Notes have not been registered under the Securities Act
and are subject to restrictions under Rule 144A under the Securities Act.

 

9.14.                     [Intentionally omitted].

 

9.15.                     The Company will reserve and keep available at all
times, free of pre-emptive rights, the full number of shares of Common Stock
issuable upon conversion of the New Notes.

 

9.16.                     None of the Company, its affiliates, or any person
acting on its or their behalf  will engage in any form of general solicitation
or general advertising (within the meaning of Regulation D) in connection with
the Exempted Exchanges.

 

9.17.                     Between the date hereof and the Closing Date, the
Company will not do or authorize any act or thing that would result in an
adjustment of the conversion price of the Existing Notes or  New Notes.

 

9.18.                     The Company will not take, directly or indirectly, any
action designed to or which has constituted or which might reasonably be
expected to cause or result, under the 1934 Act or otherwise, in stabilization
or manipulation of the price of any security of the Company to facilitate the
sale or resale of the New Notes.

 

9.19.                     The Dealer Manager acknowledges that the New Notes and
the Common Stock issuable upon conversion thereof have not been and will not be
registered under the Securities Act and may not be offered or sold within the
United States or to, or for the account or benefit of, U.S. persons, except
pursuant to an exemption from,

 

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or in a transaction not subject to, the registration requirements of the
Securities Act.

 

9.20.                     The Dealer Manager represents and warrants to and
agrees with the Company that:

 

(i)                                     it has not solicited or made any
Exempted Exchanges within the United States or to, or for the account or benefit
of, U.S. persons (x) as part of their distribution at any time or (y) otherwise
until one year after the later of the commencement of the offering and the date
of closing of the offering except to those it reasonably believes to be
“qualified institutional buyers” (as defined in Rule 144A under the Securities
Act);

 

(ii)                                  it and any person acting on its behalf
will not solicit more than six (6) holders of Existing Notes in connection with
the Exempted Exchanges and will not exchange more than $154.35 million principal
amount of Existing Notes;

 

(iii)                               neither it nor any person acting on its
behalf has solicited or will solicit any Exempted Exchanges in the United States
by means of any form of general solicitation or general advertising (within the
meaning of Regulation D) in the United States;

 

(iv)                              in connection with any solicitation of
Exempted Exchanges, it has taken or will take reasonable steps to ensure that
the acquirer of such New Notes is aware that such sale is being made in
transactions exempt from the registration requirements of the Securities Act;

 

(v)                                 it has not offered or sold and  will not
offer or sell any New Notes to persons in the United Kingdom except to persons
whose ordinary activities involve them in acquiring, holding, managing or
disposing of investments (as principal or as agent) for the purposes of their
businesses or otherwise in circumstances which have not resulted and will not
result in an offer to the public in the United Kingdom within the meaning of the
Public Offers of Securities Regulations 1995.

 

10                                  Indemnification

 

Notwithstanding any other provision of this Agreement, in the event that the
Dealer Manager becomes involved in any capacity other than as a noteholder in
any action, claim, suit, proceeding, investigation or inquiry (including without
limitation any shareholder, noteholder or derivative action or arbitration
proceeding) (collectively a “Proceeding”) in connection with any matter in any
way relating to, or referred to in this Agreement or arising out of, or alleged
to arise out of, the matters contemplated by this Agreement, including, without
limitation, matters which arise out of, or are alleged to arise out of, or are
based upon (i) a breach of any of the representations, warranties and agreements
made by the Company herein or a failure by the Company to comply with the

 

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covenants contained herein; (ii) any untrue statement or alleged untrue
statement of a material fact contained in any Exchange Materials (other than UBS
Information) or any other document used by the Company in connection with the
Exempted Exchanges; (iii) any omission or alleged omission to state any material
fact required to be stated in any Exchange Materials or any other document used
by the Company in connection with the Exempted Exchanges or necessary to make
the statements therein not misleading (other than UBS Information); (iv) any
action or failure to act by the Company, or any of its officers, directors or
affiliates in connection with the Exempted Exchanges; or (v) any services
rendered by the Dealer Manager pursuant to this Agreement, the Company will
indemnify and reimburse the Dealer Manager promptly upon request for its
reasonable legal and other expenses (including the reasonable cost of any
investigation and preparation) as they are reasonably incurred by the Dealer
Manager in connection therewith; provided, however, that with respect to any
untrue statement, or alleged untrue statement or omission of material fact or
alleged omission of material fact made in the Exchange Materials, the indemnity
agreement contained in this Section shall not inure to the benefit of the Dealer
Manager to the extent that any such legal and other expenses occur under the
circumstances where it shall have been determined by a court of competent
jurisdiction by final and nonappealable judgment that (w) the Company had
previously furnished to the Dealer Manager a reasonable amount of Exchange
Materials and in a sufficient quantity, (x) the untrue statement or alleged
untrue statement or omission of material fact or alleged omission of material
fact was corrected in such Exchange Materials and (z) there was not sent or
given to the party initiating the Proceeding the corrected Exchange Materials.
 Notwithstanding anything herein to the contrary, the Company shall not,
however, as to any person seeking indemnification or contribution hereunder, be
responsible for any losses, claims, damages, liabilities or expenses pursuant to
this Section 10 which have been finally judicially determined to result from (i)
willful misconduct or gross negligence on the part of any such person, or (ii) a
breach by the Dealer Manager of Section 9.20(ii).  The foregoing indemnity shall
be in addition to any liability the Company might otherwise have to the Dealer
Manager at common law or otherwise.  The Company agrees to notify the Dealer
Manager promptly of the assertion of any such Proceeding against the Company, or
any of its officers, directors, employees or agents or any person who controls
any of the foregoing within the meaning of Section 20(a) of the 1934 Act.  In
the event that it is judicially determined that the Dealer Manager was not
entitled to receive payments for such expenses or losses hereunder, the Dealer
Manager shall promptly return to the Company all sums that have been advanced
pursuant hereto.

 

If such indemnification is unavailable or insufficient (other than as a result
of the failure to give notice required by the next paragraph), to contribute to
any such losses, claims, damages and liabilities involved in such proportion
that is appropriate to reflect the relative benefits of the Company and its
affiliates on the one hand, and the Dealer Manager on the other, in the matters
contemplated by this Agreement or (B) if the allocation provided by clause (A)
is not permitted by applicable law, in such proportion as is appropriate to
reflect not only the relative benefits referred to in clause (A) above but also
the relative fault of the Company, on the one hand and of the Dealer Manager on
the other hand in connection with the action, inaction, statements or omissions
which

 

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resulted in such losses, claims, damages, liabilities or expenses, as well as
any other relevant equitable considerations.  For purposes of clauses (A) and
(B) in the immediately foregoing sentence, the relative benefits received by the
Company, on the one hand, and the Dealer Manager, on the other hand, in
connection with the Exempted Exchanges shall be deemed to be in the same
proportion as the aggregate principal amount of Notes exchanged pursuant to the
Exempted Exchanges bears to the fees actually received by the Dealer Manager
hereunder, and the relative fault of the Company, on the one hand, and the
Dealer Manager, on the other hand, shall be determined by reference to, among
other things, whether any such untrue or alleged untrue statement of a material
fact or omission or alleged omission to state a material fact relates to
information supplied by the Company, on the one hand, or by the Dealer Manager,
on the other hand, and the parties’ relative intent, knowledge, access to
information and opportunity to correct or prevent such statement or omission.
The Company and the Dealer Manager agree that it would not be just and equitable
if contribution pursuant to this Section 10 were determined by pro rata
allocation or by any other method of allocation which does not take account of
the equitable considerations referred to above.

 

If any litigation or proceeding is brought against the Dealer Manager in respect
of which indemnification may be sought against the Company pursuant to this
Section 10, the Dealer Manager shall promptly notify the Company in writing of
the commencement of such litigation or proceeding. Failure to so notify the
Company shall not, however, relieve the Company from any liability which it may
have on account of this indemnity or otherwise, unless such failure materially
prejudices the ability of the Company to exercise substantial rights and
defenses. In case any such litigation or proceeding shall be brought against the
Dealer Manager, the Company shall be entitled to participate in such litigation
or proceeding and, to the extent the Company may wish, after written notice from
the Company to the Dealer Manager, to assume the defense of such litigation or
proceeding with counsel of its choice at its expense; provided, however, that
such counsel shall be satisfactory to the Dealer Manager in the exercise of its
reasonable judgment. Notwithstanding the election of the Company to assume the
defense of such litigation or proceeding, the Dealer Manager shall have the
right to employ separate counsel and to participate in the defense of such
litigation or proceeding, and the Company shall bear the reasonable fees, costs
and expenses of such separate counsel and shall pay such fees, costs and
expenses (provided that, with respect to any single litigation or proceeding or
with respect to several litigations or proceedings involving substantially
similar legal claims, the Company shall not be required to bear the fees, costs
and expenses of more than one such counsel other than one local counsel) if (i)
the Dealer Manager shall have been advised by its counsel in writing (with a
copy to the counsel appointed by the Company, so long as such delivery could not
reasonably be expected to result in the loss of any privilege) that there may be
legal defenses available to it that are different from or additional to those
available to the Company, such that it would render representation by counsel to
the Company inappropriate or inadvisable for the Dealer Manager, (ii) the
Company shall not have employed counsel satisfactory to the Dealer Manager in
the exercise of the Dealer Manager’s reasonable judgment to represent the Dealer
Manager within a reasonable time after notice of the institution of such
litigation or proceeding or (iii) the Company shall authorize in writing the
Dealer Manager to employ separate

 

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counsel at the expense of the Company. After notice from the Company to the
Dealer Manager of the Company’s election so to assume the defense thereof and
approval by the Dealer Manager of the Company’s counsel appointed to defend such
action, the Company will not be liable to the Dealer Manager under this Section
10 for (A) any legal or other expenses, unless the Dealer Manager shall have
employed separate counsel in accordance with the immediately preceding sentence,
and/or (B) the costs and expenses of any settlement, compromise or consent to
the entry of any judgment in respect of any pending or threatened claim, action,
suit or proceeding effected by the Dealer Manager without the consent of the
Company, which consent shall not be unreasonably withheld or delayed. In any
action or proceeding the defense of which the Company so assumes, the Dealer
Manager shall have the right to participate in such litigation and retain its
own counsel at the Dealer Manager’s own expense. Without the prior written
consent of the Dealer Manager, which shall not be unreasonably withheld or
delayed, the Company will not settle, compromise or consent to the entry of any
judgment in respect of any pending or threatened claim, action, suit or
proceeding in respect of which indemnification would reasonably likely be sought
hereunder (whether or not the Dealer Manager is a party to such claim, action,
suit or proceeding), unless such settlement, compromise or consent (x) includes
an unconditional release of the Dealer Manager from all liability arising out of
such claim, action, suit or proceeding and (y) does not impose any actual or
potential liability upon the Dealer Manager and does not contain any factual or
legal admission by or with respect to the Dealer Manager or any adverse
statement with respect to the character, professionalism, due care, loyalty,
expertise or reputation of the Dealer Manager or any action or inaction by the
Dealer Manager. Pursuant to the terms of this Section 10, the Company and the
Dealer Manager agree to notify each other promptly of the assertion of any claim
against it, any of their respective officers or directors or any entity or
person who controls either the Company or the Dealer Manager within the meaning
of Section 20(a) of the 1934 Act in connection with the Exempted Exchanges. For
purposes of this Section 10, the term Dealer Manager shall include UBS
Securities LLC, its affiliates, officers, directors, employees and agents, and
any person controlling the Dealer Manager or any of such affiliates (within the
meaning of Section 20(a) of the 1934 Act).  The foregoing agreement shall be in
addition to any rights that any indemnified party may have at common law or
otherwise.

 

11                                  Indemnification and Reimbursement;
Representations and Warranties to Remain Operative

 

The indemnity, reimbursement and contribution agreements contained in Section 10
hereof and the representations and warranties of the Company set forth in this
Agreement shall remain operative and in full force and effect regardless of (a)
any failure to commence, or the withdrawal, rescission, termination or
consummation of, the Exempted Exchanges or the termination or assignment of this
Agreement, (b) any investigation made by or on behalf of any party entitled to
indemnification pursuant to the terms of Section 10 hereof and (c) any
withdrawal by you pursuant to Section 4.2 hereof.

 

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12                                  Conditions to Obligations of Dealer Manager

 

Your obligations hereunder shall at all times be subject, in your reasonable
discretion, to the satisfaction of the following conditions:

 

12.1.                     all representations, warranties and other statements
of the Company contained herein at all times during the period beginning and
including the date hereof and ending on, and including, the Closing Date, will
be true and correct;

 

12.2.                     the Company, at all times during the period between
the date hereof and the Closing Date, shall have performed all of its
obligations hereunder and under the New Notes Indenture and the Registration
Rights Agreement  to be performed;

 

12.3.                     no stop order, restraining order or denial of an
application for approval shall have been issued and no litigation shall have
been commenced or threatened in writing before any regulatory authority or other
public body or court of any jurisdiction with respect to the Exempted Exchanges
which you, in good faith, believe makes it inadvisable for you to continue to
act hereunder;

 

12.4.                     the Company shall have delivered to you opinions
addressed to you dated as of the Closing Date, of the Company’s counsel and
internal intellectual property counsel, substantially in the form of Exhibits
B-1 and B-2, and a letter from the Vice President of Regulatory Affairs of the
Company in the form of Exhibit B-3; and (B) Cleary, Gottlieb, Steen & Hamilton
shall have delivered to you opinions addressed to you dated as of the Closing
Date in form and substance satisfactory to you;

 

12.5.                     the Company shall have delivered to you as of the
Closing Date, a certificate, dated the date of its delivery, signed by either
its Chief Executive Officer or its Chief Financial Officer, to the effect that
(i) the signatory of such certificate has carefully examined the Exchange
Materials and no event has occurred as a result of which it is necessary to
amend or supplement the Exchange Materials in order to make the statements
therein not untrue or misleading in any material respect and there has been no
document required to be filed or submitted under the 1934 Act and the rules and
regulations thereunder that upon such filing or submission would be deemed to be
incorporated by reference into the Exchange Materials that has not been so
filed; (ii) each of the representations and warranties of the Company (as
applicable with respect to the relevant certificate) contained in this Agreement
are, at the time such certificate is delivered, true and correct on the Closing
Date, with the same effect as if made on the Closing Date, provided, however,
that if any such representation or warranty is already qualified as to
materiality, such representation or warranty, as so qualified, is true and
correct in all respects on the Closing Date; and (iii) each of the covenants
required herein to be performed by the Company (as applicable with respect to
the relevant certificate) on or prior to the delivery of such certificate has
been duly, timely and fully performed and each condition herein required to be
complied with by the

 

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Company (as applicable with respect to the relevant certificate) on or prior to
the date of such certificate has been duly, timely and fully complied with;

 

12.6.                     on the date hereof and the Closing Date, the Company
shall have furnished to you a “comfort letter” of each of PricewaterhouseCoopers
LLP and Ernst & Young LLP, dated as of the date hereof or the Closing Date, as
the case may be, addressed to you, in form and substance satisfactory to you and
your counsel, containing statements and information of the type ordinarily
included in accountants’ “comfort letters” with respect to financial statements
and certain financial information contained in the Offering Memorandum; provided
that the letter delivered on the Closing Date shall use a “cut-off” date not
earlier than two days before the Closing Date;

 

12.7.                     The New Notes shall have been designated as
PORTAL-eligible securities in accordance with the rules and regulations of the
NASD and the New Notes shall be eligible for clearance and settlement through
DTC;

 

12.8.                     The Company shall have caused the shares of Common
Stock initially issuable upon conversion of the New Notes to be approved for
quotation, subject to issuance, on the Nasdaq Stock Market.

 

12.9.                     The Company shall have duly authorized, executed and
delivered the Registration Rights Agreement.

 

12.10.              subsequent to the Commencement Date and prior to the Closing
Date,

 

(i)                                     there shall not have occurred any
downgrading, nor shall any notice have been given of any intended or potential
downgrading or of any review for a possible change that does not indicate the
direction of the possible change, in the rating accorded any of the Company’s
securities by any “nationally recognized statistical rating organization,” as
such term is defined for purposes of Rule 436(g)(2) under the Securities Act;
and

 

(ii)                                  there shall not have occurred any change,
or any development involving a prospective change, in the condition, financial
or otherwise, or in the earnings, prospects, business or operations, of the
Company and its subsidiaries, taken as a whole, from that set forth in the
Exchange Materials (exclusive of any amendments or supplements thereto
subsequent to the date of this Agreement), that, in your judgment, is material
and adverse and that makes it, in your judgment, impracticable to proceed with
the Exchange Transaction in the manner contemplated in the Exchange Materials;
and

 

12.11.              the Company shall have furnished to you such certificates or
other documents, in addition to those specifically mentioned herein, as you or
your counsel may have reasonably requested.

 

12.12.              In the event that at any time during the period between the
date hereof and the Closing Date any representation, warranty or other statement
ceases to be true and

 

22

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correct, the Company shall promptly use its best efforts to seek to cause such
representation, warranty or other statement to be true and correct.

 

12.13.              You shall have a reasonable period of time after discovering
or being informed of a breach in any of the foregoing conditions up to and
including the Closing Date to elect whether to continue to act as Dealer
Manager. Your resignation as Dealer Manager as a result of a breach of the
foregoing conditions shall be without prejudice to your entitlement to expenses
under Section 4.2 hereof.

 

13                                  Publications

 

The Company agrees that the Dealer Manager has the right to place advertisements
in financial and other newspapers and journals at its own expense describing its
services to the Company hereunder, provided such advertisements are provided to
and approved in writing by the Company prior to their use.

 

14                                  Confidentiality

 

Any advice or opinions provided by you in connection with or related to this
Agreement will not be disclosed or referred to publicly or to any third party
(other than attorneys and accountants of the Company who agree to keep such
advice or opinions confidential) by the Company or any of its affiliates except
in accordance with your prior written consent, which shall not be unreasonably
withheld or delayed or as may be required by applicable laws or except as may be
required by law, regulation, legal process or regulatory authority or in any
action, suit or proceeding to which the Company is a party involving the
Exempted Exchanges; provided that the Company shall provide the Dealer Manager
with prompt written notice of any such requirement so that the Dealer Manager
may seek a protection order or other appropriate remedy.

 

15                                  Termination

 

This Agreement shall terminate upon the expiration, termination or withdrawal of
the Exempted Exchanges or upon the withdrawal by you as Dealer Manager pursuant
to Section 4.2 hereof. In addition, your services as Dealer Manager may be
terminated by you or by the Company upon 10 days prior written notice to the
other party without liability or continuing obligation of the Company or the
Dealer Manager. In the event your services as Dealer Manager are terminated by
the Company, the Dealer Manager shall be entitled to any Fee payable pursuant to
Section 5 hereof in accordance with the terms thereof (but the Dealer Manager
shall not be entitled to any Fee hereunder if (a) the Company shall have
terminated such services with cause, including a breach by the Dealer Manager of
Section 9.20(ii) or (b) the Dealer Manager shall otherwise have acted in bad
faith or in a grossly negligent manner or (c) there has occurred any material
adverse change in the financial markets in the United States or the
international financial markets, any outbreak of hostilities or escalation
thereof or other calamity or crisis or any change or development involving a
prospective change in national or international political, financial or economic
conditions, in each case the effect of which is such as to make it, in the
reasonable judgment of the Dealer Manager, impracticable to enforce contracts
for the sale of the New Notes, or (d) if trading in any securities of the
Company

 

23

--------------------------------------------------------------------------------

 

has been suspended or materially limited by the Commission or the Nasdaq
National Market, or if trading generally on the American Stock Exchange or the
New York Stock Exchange or in the Nasdaq National Market has been suspended or
materially limited, or minimum or maximum prices for trading have been fixed, or
maximum ranges for prices have been required, by any of said exchanges or by
such system or by order of the Commission, the NASD or any other governmental
authority, in each case the effect of which is such as to make it, in the
reasonable judgment of the Dealer Manager, impracticable or inadvisable to
proceed with the Exempted Exchanges or (e) if a banking moratorium has been
declared by either Federal or New York authorities, the effect of which is such
as to make it, in the reasonable judgment of the Dealer Manager, impracticable
or inadvisable to proceed with the Exempted Exchanges), and further, all
reasonable expenses incurred by the Dealer Manager as a result of services
rendered prior to the date of the termination shall become immediately payable
in full. In the event you terminate your services as Dealer Manager hereunder,
the Dealer Manager shall be entitled to all reasonable expenses incurred by the
Dealer Manager as a result of services rendered prior to the date of
termination, which shall become immediately due and payable in full, but shall
not be entitled to any Fee hereunder unless the Dealer Manager shall have
terminated such services with cause or the Company shall otherwise have acted in
bad faith, in which case the Dealer Manager shall be entitled to any Fee payable
pursuant to Section 5 hereof in accordance with the terms thereof. The
provisions of Sections 3, 5, 6, 8, 9, 10, 11, 14, 15, 17, 18, 19, 20 and 22
hereof shall survive the termination of this Agreement for any reason
whatsoever. Unless this Agreement has been terminated pursuant to clause (a) or
(b) of this paragraph, the Dealer Manager shall be entitled to payment in full
of the Fee payable under Section 5 if at any time prior to the expiration of 6
months after the termination of this Agreement, the Company consummates, or
enters into a definitive agreement that subsequently results in the consummation
of, the Exempted Exchanges or any similar transaction. For the avoidance of
doubt, in the event that the Exempted Exchanges do not proceed, the Dealer
Manager shall be entitled only to all expenses as contemplated in Section 6
hereof.

 

16                                  Notices

 

All notices and other communications required or permitted to be given under
this Agreement shall be in writing and shall be deemed to have been duly given
if delivered personally to the parties hereto as follows:

 

If to you:

 

UBS Securities LLC
677 Washington Boulevard
Stamford, CT  06901
Attention: Liability Management Group
Facsimile: 1(203) 719-1620

 

With a copy to (which shall not constitute notice):

 

24

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UBS Securities LLC
677 Washington Boulevard
Stamford, CT  06901
Attention: Legal and Compliance Department
Facsimile: 1 (203) 719-0680

 

If to the Company:

 

Vertex Pharmaceuticals Incorporated
130 Waverly Street
Cambridge, Massachusetts 02139-4242
Attention: Kenneth S. Boger
Facsimile: (617) 444-7117

 

With a copy to (which shall not constitute notice):

 

Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
One Financial Center
Boston, Massachusetts  02111
Attention:  Michael L. Fantozzi
Facsimile:  (617) 542-2241

 

17           Successors and Assigns

 

This Agreement, including any right to indemnity or contribution hereunder,
shall inure to the benefit of and be binding upon the Company and you and such
other parties entitled to indemnification pursuant to the terms of Section 10
hereof, and the respective successors and assigns of such parties. Except as
provided in Section 9.12, nothing in this Agreement is intended, or shall be
construed, to give to any other person or entity any right hereunder or by
virtue hereof.

 

18                                  Governing Law

 

This Agreement shall be governed by and construed in accordance with the laws of
the State of New York without regard to the principles thereof relating to
conflict of laws.

 

19                                  Waiver of Jury Trial

 

EACH OF THE COMPANY AND THE DEALER MANAGER HEREBY AGREES TO WAIVE ANY RIGHT TO A
TRIAL BY JURY IN ANY PROCEEDINGS OR COUNTERCLAIM (WHETHER BASED UPON CONTRACT,
TORT OR OTHERWISE) WITH RESPECT TO ANY CLAIM, COUNTER-CLAIM OR ACTION ARISING
OUT OF OR IN CONNECTION WITH THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED
HEREBY (INCLUDING, WITHOUT LIMITATION, THE EXCHANGE OFFER AND THE CONSENT
SOLICITATION).

 

25

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20                                  Entire Agreement

 

This Agreement constitutes the entire agreement among the parties hereto and
supersedes all prior agreements, understandings and arrangements, oral or
written, among the parties hereto with respect to the subject matter hereof and
thereof.

 

21                                  Counterparts; Severability

 

This Agreement may be executed in two or more separate counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument. Any term or provision of this Agreement which is
invalid or unenforceable in any jurisdiction shall, as to such jurisdiction, be
ineffective to the extent of such invalidity or unenforceability without
rendering invalid or unenforceable the remaining terms and provisions of this
Agreement or affecting the validity or enforceability of any of the terms or
provisions of this Agreement in any other jurisdiction.

 

22                                  Amendment

 

This Agreement may not be amended except in writing signed by each party to be
bound thereby.

 

26

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Please indicate your willingness to act as Dealer Manager on the terms set forth
herein and your acceptance of the foregoing provisions by signing in the space
provided below for that purpose and returning to us a copy of this letter so
signed, whereupon this letter and your acceptance shall constitute a binding
agreement among us.

 

Very truly yours,

 

VERTEX PHARMACEUTICALS INCORPORATED

 

 

 

 

 

By:

/s/ Ian Smith

 

 

Name:

 

Title:

 

 

 

Accepted as of the date

 

first set forth above:

 

 

 

UBS SECURITIES LLC

 

 

 

 

 

By:

/s/ Chris Hite

 

 

Name: Chris Hite

 

Title: Managing Director

 

 

 

 

 

By:

/s/ Aradhana Sarin

 

 

Name:

 

Title:

 

 

27

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Exhibit A-1
Offering Memorandum

 

--------------------------------------------------------------------------------

 

Exhibit A-2
Letter of Transmittal

 

THIS DOCUMENT IS IMPORTANT AND REQUIRES YOUR IMMEDIATE ATTENTION.  If you are in
any doubt as to the action to be taken, you should immediately consult your
broker, bank manager, lawyer, accountant, investment advisor or other
professional.

 

LETTER OF TRANSMITTAL
relating to
the exempted exchanges described in
the Offering Memorandum
dated February 10, 2004
(the “Offering Memorandum”)

 

Each holder of the 5% Convertible Subordinated Notes due 2007 (the “Old Notes”)
of Vertex Pharmaceuticals Incorporated (“Vertex”) participating in the exempted
exchanges (as described in the Offering Memorandum) should complete, sign and
submit this Letter of Transmittal by fax to the trustee, US Bank National
Association (the “Trustee”), as soon as possible at fax no. (651) 495-8158,
Attention: Specialized Finance.  Delivery of this Letter of Transmittal to the
Trustee confirms your participation in the exempted exchanges on the terms
described in the Offering Memorandum.

 

Questions regarding the exempted exchanges or the completion of this Letter of
Transmittal should be directed to the Trustee at the following telephone
number:  (651) 495-3513.

 

DELIVERY OF OLD NOTES

 

To effect a valid delivery of Old Notes through the completion, execution and
delivery of a Letter of Transmittal, the undersigned must complete the tables
below entitled “Description of Old Notes Delivered” and sign the Letter of
Transmittal where indicated.

 

DESCRIPTION OF OLD NOTES DELIVERED

 

NOTE:  SIGNATURES MUST BE PROVIDED BELOW.
PLEASE READ THE ACCOMPANYING INSTRUCTIONS CAREFULLY.

 

 

Name of DTC Participant and Participant’s Account Number in which
Old Notes are held and/or the corresponding New Notes are
to be delivered

 

Aggregate Principal Amount of
Old Notes*

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

--------------------------------------------------------------------------------

*    The principal amount of Old Notes delivered must be in denominations of
US$1,000 and whole multiples of US$1,000. 

 

¨            Please check this box to confirm that the undersigned, or the
Beneficial Owner (as defined below) on behalf of which the undersigned is
acting, is: a “qualified institutional buyer” as defined under Rule 144A of the
U.S. Securities Act of 1933, as amended.

 

--------------------------------------------------------------------------------

 

Note:  Signatures must be provided below.
Please read the accompanying Instructions carefully.

 

Ladies and Gentlemen:

 

The undersigned hereby delivers to Vertex the aggregate principal amount of Old
Notes indicated in the table above entitled “Description of Old Notes
Delivered”.

 

The undersigned understands that delivery of Old Notes pursuant to any of the
procedures described in the Offering Memorandum and in the instructions in this
Letter of Transmittal and acceptance of such Old Notes by Vertex will constitute
a binding agreement between the undersigned and Vertex.

 

All authority conferred or agreed to be conferred by this Letter of Transmittal
shall not be affected by, and shall survive, the death or incapacity of the
undersigned, and any obligation of the undersigned hereunder shall be binding
upon the heirs, executors, administrators, trustees in bankruptcy, personal and
legal representatives, successors and assigns of the undersigned.

 

The undersigned hereby represents, warrants and agrees to the representations,
warranties and agreements set forth under “The exempted exchanges – Effect of
agreeing to the exempted exchanges” in the Offering Memorandum.

 

If the “Special Return Instructions” box (found below) is completed, please
credit the DTC account for any book-entry transfers of Old Notes not accepted
for exchange into the account so indicated.

 

The undersigned recognizes that Vertex has no obligation under the “Special
Return Instructions” provision of this Letter of Transmittal to effect the
transfer of any Old Notes from the holder(s) of Old Notes if Vertex does not
accept for exchange any of the principal amount of the Old Notes delivered
pursuant to this Letter of Transmittal.

 

SPECIAL RETURN INSTRUCTIONS
(See Instructions 2 and 5)

 

To be completed ONLY if Old Notes in the principal amount not accepted for
exchange are to be returned in the name of someone other than the person or
persons whose signature(s) appear(s) within this Letter of Transmittal and/or
sent to a DTC participant account different from that indicated in the table
entitled “Description of Old Notes Delivered.”

 

Please issue Old Notes not accepted for exchange, to:

 

Name of DTC Participant:

 

DTC Participant Account Number:

 

Contact at DTC Participant:

 

2

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SIGN HERE
(TO BE COMPLETED BY ALL CONSENTING HOLDERS DELIVERING OLD NOTES)

 

By completing, executing and delivering this Letter of Transmittal, the
undersigned hereby delivers to Vertex the principal amount of the Old Notes
listed in the table labeled “Description of Old Notes Delivered.”

 

 

 

 

Signature of Registered Holder(s) or Authorized Signatory

 

Date

(see guarantee requirement below)

 

 

 

 

 

 

 

 

Signature of Registered Holder(s) or Authorized Signatory

 

Date

(see guarantee requirement below)

 

 

 

 

 

 

 

 

Signature of Registered Holder(s) or Authorized Signatory

 

Date

(see guarantee requirement below)

 

 

 

Area Code and Telephone Number:

 

 

This Letter of Transmittal must be signed by the Registered Holder(s) exactly as
the name(s) appear(s) on a securities position listing of DTC or by any
person(s) authorized to become the Registered Holder(s) by endorsements and
documents transmitted herewith.  If the signature is by a trustee, executor,
administrator, guardian, attorney-in-fact, officer or other person, acting in a
fiduciary or representative capacity, please set forth at the line entitled
“Capacity (full title)” and submit evidence satisfactory to the Trustee and
Vertex of such person’s authority to so act.  See Instruction 3.

 

Name(s):

 

 

 

(Please Type or Print)

 

Capacity (full title):

 

 

Address:

 

(Including Zip Code)

 

MEDALLION SIGNATURE GUARANTEE
(If required—See Instruction 3)

 

Signature(s) Guaranteed by

an Eligible Institution:

 

(Authorized Signature)

 

 

(Title)

 

 

(Name of Firm)

 

 

(Address)

 

Dated:                                    , 2004

 

3

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INSTRUCTIONS

 

1.  Delivery of Letter of Transmittal.  A holder of Old Notes that wishes to
participate in the exempted exchanges must submit to the Trustee a completed
Letter of Transmittal as soon as possible.

 

2.  Amount of Delivery.  Old Notes delivered will be accepted only in
denominations of US$1,000 and whole multiples of US$1,000.

 

3.  Signatures on Letter of Transmittal; Instruments of Transfer; Guarantee of
Signatures.  For purposes of this Letter of Transmittal, the term “Registered
Holder” means an owner of record as well as any DTC participant that has Old
Notes credited to its DTC account.  Except as otherwise provided below, all
signatures on this Letter of Transmittal must be guaranteed by a recognized
participant in the Securities Transfer Agents Medallion Program, the NYSE
Medallion Signature Program or the Stock Exchange Medallion Program (each, a
“Medallion Signature Guarantor”).  Signatures on the Letter of Transmittal need
not be guaranteed if:

 

•                  the Letter of Transmittal is signed by a participant in DTC
whose name appears on a security position listing as the owner of the Old Notes
and the holder(s) has not completed either of the boxes entitled “Special Return
Instructions” on the Letter of Transmittal; or

 

•                  the Old Notes are delivered for the account of an “eligible
guarantor institution.”

 

An “eligible guarantor institution” is one of the following firms or other
entities identified in Rule 17Ad-15 under the Securities Exchange Act of 1934
(as the terms are defined in Rule 17Ad-15):

 

(A)          A BANK;

 

(B)         A BROKER, DEALER, MUNICIPAL SECURITIES DEALER, MUNICIPAL SECURITIES
BROKER, GOVERNMENT SECURITIES DEALER OR GOVERNMENT SECURITIES BROKER;

 

(C)          A CREDIT UNION;

 

(D)         A NATIONAL SECURITIES EXCHANGE, REGISTERED SECURITIES ASSOCIATION OR
CLEARING AGENCY; OR

 

(E)          A SAVINGS INSTITUTION THAT IS A PARTICIPANT IN A SECURITIES
TRANSFER ASSOCIATION RECOGNIZED PROGRAM.

 

If any of the Old Notes delivered are held by two or more Registered Holders,
all of the Registered Holders must sign the Letter of Transmittal.

 

By executing the Letter of Transmittal (or facsimile thereof), you waive any
right to receive any notice of the acceptance of your Old Notes for exchange.

 

If this Letter of Transmittal or instruments of transfer are signed by trustees,
executors, administrators, guardians or attorneys-in-fact, officers of
corporations or others acting in a fiduciary or representative capacity, such
persons should so indicate when signing and, unless waived by Vertex, evidence
satisfactory to Vertex of their authority to so act must be submitted with this
Letter of Transmittal.

 

Beneficial Owners who deliver Old Notes that are registered in the name of a
broker, dealer, commercial bank, trust company or other nominee must contact
such broker, dealer, commercial bank, trust company or other nominee if they
desire to participate in the exempted exchanges.

 

4.  Special Return Instructions.  All Old Notes delivered hereby and not
accepted for exchange will be returned to the undersigned according to the
information provided in the table entitled “Description of

 

4

--------------------------------------------------------------------------------

 

the Old Notes Delivered” or, if completed, according to the “Special Return
Instructions” box in this Letter of Transmittal.

 

5.  Requests for Assistance or Additional Copies.  Questions and requests for
assistance and requests for additional copies of the Offering Memorandum or this
Letter of Transmittal may be directed to the Trustee at the address and
telephone number indicated herein.

 

In order to participate in the exempted exchanges, a holder of Old Notes should
send or deliver a properly completed and signed Letter of Transmittal and any
other required documents to the Trustee to the fax number set forth below.

 

The Trustee for the exempted exchanges is:

 

US Bank National Association

 

60 Livingston Avenue

St. Paul, Minnesota 55107

Attention: Specialized Finance

Tel:  (651) 495-3513
Fax:  (651) 495-8158

 

 

The Dealer Manager for the exempted exchanges is:

 

UBS Securities LLC

 

677 Washington Boulevard
Stamford, Connecticut 06901
Attention: William Schneider

Tel:  (203) 719-4210

 

5

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Exhibit B
Opinion of Company Counsel

 

 

Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.

 

One Financial Center

Boston, Massachusetts 02111

 

 

 

617 542 6000
617 542 2241 fax

 

 

February 13, 2004

 

 

UBS Securities LLC

677 Washington Boulevard

Stamford, Connecticut 06901

 

 

Ladies and Gentlemen:

 

This opinion is being furnished to you pursuant to Section 12.4 of the Dealer
Manager Agreement, dated February 9, 2004 (the “Dealer Manager Agreement”) by
and between you (the “Dealer Manager”) and Vertex Pharmaceuticals Incorporated,
a Massachusetts corporation (the “Company”), pursuant to which the Company will
exchange (each, an “Exempted Exchange” and, collectively, the “Exempted
Exchanges”) certain of its outstanding 5.00% Convertible Subordinated Notes due
2007 (the “Old Notes”) for its 5 3/4% Convertible Senior Subordinated Notes due
2011 (the “New Notes”), as more fully described in the offering memorandum dated
February 9, 2004 (the “Offering Memorandum”) and the related letter of
transmittal dated February 9, 2004 (the “Letter of Transmittal” and, together
with the Offering Memorandum, the “Offering Documents”).  The New Notes will be
issued under an indenture dated as of February 13, 2004 (the “Indenture”)
between the Company and US Bank National Association, as trustee (the
“Trustee”).  Holders of the New Notes will have the registration rights set
forth in the Registration Rights Agreement dated as of February 13, 2004 (the
“Registration Rights Agreement”) by and among the Company and the Dealer
Manager.  Capitalized terms defined in the Dealer Manager Agreement and not
otherwise defined herein are used herein with the meanings so defined in the
Dealer Manager Agreement.

 

We have acted as outside counsel for the Company in connection with the
preparation, execution and delivery of the Dealer Manager Agreement and the
consummation of the transactions contemplated thereby.  In connection therewith,
we have examined executed originals or counterparts of the Dealer Manager
Agreement, the Registration Rights Agreement and the Indenture (collectively,
the “Transaction Documents”), the Offering Documents and such other documents as
we have deemed necessary for purposes of this opinion.

 

Insofar as this opinion relates to factual matters, we have relied upon
representations and warranties of the Company set forth in the Transaction
Documents, certificates of officers of the Company and of public officials, and
certificates delivered

 

Boston New York Reston Washington

 

--------------------------------------------------------------------------------

 

to you in connection with the Transaction Documents and the transactions
contemplated thereby.

 

As used herein, any reference to “our knowledge”, “best of our knowledge”, “of
which we have knowledge”, “known to us” or words of similar import, shall mean
the conscious awareness of the existence or absence of any facts or other
information by any lawyer in this firm who was involved in representing the
Company in connection with the transactions contemplated by the Transaction
Documents or is otherwise involved on an ongoing basis in providing legal
services to the Company.  Except as expressly set forth in this opinion, we have
not undertaken any independent investigation, including, without limitation, any
investigation of corporate, court or other documents or records, to determine
the existence or absence of any such facts or other information, and no
inference as to our knowledge of the existence or absence of any facts or other
information should be drawn from the fact of our representation of the Company.

 

In rendering the opinions set forth herein, we have assumed without independent
inquiry or investigation, (i) the genuineness of all signatures on all documents
and instruments examined by us, (ii) the authenticity of all documents submitted
to us as originals, and (iii) the conformity to originals of all documents
submitted to us as certified, photostatic or conformed copies, and the
authenticity of the originals of such documents.  We have also assumed that each
of the parties to the Transaction Documents (other than the Company) has all
requisite power and authority and has taken all necessary action (corporate or
otherwise) to execute and deliver the Transaction Documents to which it is a
party and to effect the transactions contemplated thereby and that the
Transaction Documents constitute the legal, valid and binding obligation of each
of such other parties enforceable in accordance with their respective terms.

 

Our opinions contained in paragraphs (vi), (vii) and (viii) as to enforceability
are subject to the further qualification that such enforceability may be (1)
limited by bankruptcy, insolvency (including, without limitation, fraudulent
conveyances and fraudulent transfers), reorganization, moratorium and other
similar laws relating to or affecting creditors’ rights generally, (2) limited
by general equitable principles, including, without limitation, concepts of
materiality, reasonableness, good faith and fair dealing (regardless of whether
such enforceability is considered in a proceeding in equity or at law), (3)
subject to the effect of any public policy considerations or court decisions
which may limit the rights of any person or entity to obtain indemnification,
and (4) subject to the effects of generally applicable rules of law that (A)
limit or affect the enforcement of provisions that purport to require waiver or
modification of the obligations of good faith, fair dealing, diligence,
reasonableness or due notice or to waive equitable rights, remedies, or
defenses, or to release or indemnify a party from or against liability for the
party’s own unlawful or willful misconduct, recklessness or gross negligence, or
to preclude modification of the Transaction Documents through custom or course
of conduct, (B) limit the enforceability of any liquidated damages provisions to
the extent

 

2

--------------------------------------------------------------------------------

 

that the damages assessed are ascertainable, or (C) provide that forum selection
clauses are not necessarily binding on the court or courts in the forum
selected.

 

We call your attention to the fact that members of this firm are admitted to
practice law in the Commonwealth of Massachusetts and the State of New York. 
Accordingly, no opinion is expressed herein with respect to any matter, which is
determined by the law of any jurisdiction except the federal laws of the United
States of America, the laws of The Commonwealth of Massachusetts and the laws of
the State of New York.  Insofar as this opinion addresses matters governed by
laws of any other jurisdiction, this opinion is delivered as though such matters
were governed by and construed in accordance with the domestic substantive laws
of The Commonwealth of Massachusetts (without regard to the application of any
conflict of law rule that would result in the application of the domestic
substantive law of any other jurisdiction). Moreover, we express no opinion and
give no statement herein related to any filing or other requirements under
Section 14 of the 1934 Act and the rules and regulations promulgated by the
Commission thereunder.

 

Based upon and subject to the foregoing assumptions, limitations and
qualifications, and subject to the penultimate paragraph of this letter, we are
of the opinion that:

 

(i)            The Company has been duly incorporated and validly exists as a
corporation in good standing under the laws of the Commonwealth of
Massachusetts.

 

(ii)           The Company has corporate power and authority to own, lease and
operate its properties and to conduct its business as described in the Offering
Memorandum and to enter into and perform its obligations under the Dealer
Manager Agreement, the Registration Rights Agreement, the Indenture and the New
Notes.

 

(iii)          The Company is duly qualified as a foreign corporation to
transact business and is in good standing in each jurisdiction within the United
States in which such qualification is required, whether by reason of the
ownership or leasing of property or the maintenance of an office, except where
the failure so to qualify or to be in good standing could not reasonably be
expected to result in a Material Adverse Effect.

 

(iv)          The authorized, issued and outstanding capital stock of the
Company is as set forth in the Offering Memorandum in the column entitled
“Actual” under the caption “Capitalization” (except for subsequent issuances, if
any, pursuant to the Dealer Manager Agreement or pursuant to reservations,
agreements, employee benefit plans or the exercise of convertible securities or
options referred to in the Offering Memorandum); the shares of issued and
outstanding capital stock of the Company issued since September 30, 2003 have
been duly authorized and validly issued and are fully paid and non-assessable;
and none of the outstanding shares of capital stock of the Company was

 

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issued in violation of the preemptive or other similar rights of any
securityholder of the Company, pursuant to any agreement disclosed to us after
inquiry of the Company.

 

(v)           Vertex Securities Trust (“Vertex Securities”) has been duly
organized and is validly existing as a business trust in good standing under the
laws of the Commonwealth of Massachusetts, has corporate power and authority to
own, lease and operate its properties and is duly qualified as a foreign
corporation to transact business and is in good standing in each jurisdiction in
which such qualification is required, whether by reason of the ownership or
leasing of property or the maintenance of an office, except where the failure so
to qualify or to be in good standing could not reasonably be expected to result
in a Material Adverse Effect.  To the best of our knowledge and information, the
Company does not have any subsidiaries other than Vertex Pharmaceuticals (San
Diego) LLC, Aurora Instruments Holding LLC, Aurora Instruments LLC, Vertex
Holdings, Inc., Vertex Securities Trust and Vertex Pharmaceuticals (Europe)
Limited.

 

(vi)          The Dealer Manager Agreement has been duly authorized, executed
and delivered by the Company.  The Registration Rights Agreement has been duly
authorized, executed and delivered by the Company, and constitutes a valid and
legally binding obligation of the Company, enforceable against the Company in
accordance with its terms.

 

(vii)         The Indenture has been duly authorized, executed and delivered by
the Company and (assuming the due authorization, execution and delivery thereof
by the Trustee) constitutes a valid and binding agreement of the Company,
enforceable against the Company in accordance with its terms.

 

(viii)        The New Notes are in the form contemplated by the Indenture and
have been duly authorized by the Company; the New Notes have been executed and
authenticated in the manner provided in the Indenture and when delivered in
exchange for the Old Notes in accordance with the Exempted Exchanges (assuming
the due authorization, execution and delivery of the Indenture by the Trustee)
constitute legal, valid and binding obligations of the Company, enforceable
against the Company in accordance with their terms, and are entitled to the
benefits of the Indenture.

 

(ix)           Upon issuance and delivery of the New Notes in accordance with
the Dealer Manager Agreement and the Indenture, the New Notes shall be
convertible at the option of the holder thereof for shares of Common Stock in
accordance with the terms of the New Notes and the Indenture; the shares of
Common Stock initially issuable upon conversion of the New Notes have been duly
authorized and reserved for issuance upon such conversion by all necessary
corporate action; such shares, when issued upon such conversion against payment
of the conversion price and in accordance with the provisions of the New Notes
and the Indenture, will be validly issued and will be fully paid and
non-assessable and free and clear of all liens, encumbrances, equities or claims
imposed by or

 

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arising from actions of the Company and no holder of such Common Stock is or
will be subject to personal liability by reason of being such a holder.

 

(x)            The issuance of the shares of Common Stock upon conversion of the
New Notes is not subject to the preemptive or other similar rights of any
securityholder of the Company pursuant to any agreement disclosed to us after
inquiry of the Company.

 

(xi)           The Indenture conforms in all material respects with the 1939
Act.

 

(xii)          To the best of our knowledge, except as disclosed in the Offering
Memorandum, there is no pending or threatened action, suit, proceeding, inquiry
or investigation, to which the Company or any Subsidiary is a party, or to which
the property of the Company or any Subsidiary thereof is subject, before or
brought by any court or governmental agency or body, which could reasonably be
expected to result in a Material Adverse Effect, or which could materially and
adversely affect the properties or assets thereof or the consummation of the
transactions contemplated in the Dealer Manager Agreement, the Indenture, the
New Notes and the Registration Rights Agreement or the performance by the
Company of its obligations thereunder or the transactions contemplated by the
Offering Memorandum.

 

(xiii)         The information in the Offering Memorandum under “The exempted
exchanges,” “Description of new notes” and “Certain U.S. federal income tax
consequences,” and the information in the description of the Company’s common
stock and the description of the rights under the Company’s Rights Agreement,
contained on pages 78-79 and on page 84, respectively, of the Company’s
Amendment No. 1 to the Registration Statement on Form S-4 (Reg. No. 333 -
61480), incorporated by reference in the Offering Memorandum, to the extent that
it constitutes matters of law, summaries of legal matters or legal documents or
instruments, the Company’s charter and bylaws, or legal conclusions, has been
reviewed by us and fairly summarizes the matters referred to therein.  To the
best of our knowledge, there are no other statutes or regulations that are
required to be described in the Offering Memorandum that are not described as
required.

 

(xiv)        The New Notes conform in all material respects to the description
thereof contained in the Offering Memorandum

 

(xv)         To the best of our knowledge, there are no franchises, contracts,
indentures, mortgages, loan agreements, notes or leases that would be required
to be described in the Offering Memorandum that are not described or referred to
in the Offering Memorandum, and the descriptions thereof or references thereto
fairly summarize such arrangements.

 

(xvi)        To the best of our knowledge, neither the Company nor Vertex
Securities is in violation of its charter or by-laws and, based solely on an
inquiry of the Company, we know of no default by the Company or Vertex
Securities that exists in the due

 

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performance or observance of any material obligation, agreement, covenant or
condition contained in any contract, indenture, mortgage, loan agreement, note,
lease or other agreement or instrument that is described or referred to in the
Offering Memorandum.

 

(xvii)       No filing with, or authorization, approval, consent, license,
order, registration, qualification or decree of, any court or governmental
authority or agency, domestic or foreign (other than such as may be required
under the applicable securities laws of the various jurisdictions in which the
New Notes will be offered or sold, as to which we need express no opinion) is
necessary or required in connection with the due authorization, execution and
delivery of the Dealer Manager Agreement or the Registration Rights Agreement or
the due execution, delivery or performance of the Indenture by the Company in
connection with the Exempted Exchanges or for the issuance of shares of Common
Stock upon conversion of New Notes.

 

(xviii)      It is not necessary in connection with the consummation of the
Exempted Exchanges in the manner contemplated by the Dealer Manager Agreement
and the Offering Memorandum or in connection with the conversion of the Notes
into shares of the Common Stock in the manner contemplated in the Indenture, to
register the New Notes or the shares of Common Stock issuable upon conversion of
the Notes under the Securities Act or to qualify the Indenture under the Trust
Indenture Act.

 

(xix)         The execution, delivery and performance of the Dealer Manager
Agreement, the Indenture, the Registration Rights Agreement and the New Notes
and the consummation of the transactions contemplated in the Dealer Manager
Agreement, the Registration Rights Agreement, the Indenture and in the Offering
Memorandum (including the issuance of the shares of Common Stock issuable upon
conversion of the New Notes) and compliance by the Company with its obligations
under the Dealer Manager Agreement, the Indenture, the Registration Rights
Agreement and the New Notes do not and will not, whether with or without the
giving of notice or lapse of time or both, conflict with or constitute a breach
of, or default under or result in the creation or imposition of any lien, charge
or encumbrance upon any property or assets of the Company or Vertex Securities
pursuant to any contract, indenture, mortgage, deed of trust, loan or credit
agreement, note, lease or any other agreement or instrument, referred to in the
Offering Memorandum, to which the Company or Vertex Securities is a party or by
which either of them may be bound, or to which any of the property or assets of
the Company or Vertex Securities is subject (except for conflicts, breaches or
defaults, liens charges or encumbrances that could not reasonably be expected to
have a Material Adverse effect), nor will such action result in any violation of
the provisions of the charter or by-laws of the Company or Vertex Securities, or
any applicable law, statute, rule, regulation (other than such as may be
required under the applicable securities laws of the various jurisdictions in
which New Notes will be offered or sold, as to which we offer no opinion), and
any judgment, order, writ or decree, known to us, of any government, government
instrumentality or court, domestic or foreign, having

 

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jurisdiction over the Company or Vertex Securities or any of their respective
properties, assets or operations.

 

(xx)          The Company is not, and, upon the consummation of the Exempted
Exchanges as described in the Offering Memorandum, will not be, an “investment
company” or an entity “controlled” by an “investment company,” as such terms are
defined in the U.S. Investment Company Act of 1940.

 

In the course of the preparation of the Offering Memorandum, we participated in
conferences with officers, representatives and in-house attorneys of the
Company, representatives of the independent public accountants for the Company,
and with the Dealer Manager and its counsel during which the contents of the
Offering memorandum and related matters were discussed, and although we have not
verified and are not passing upon and do not assume any responsibility for the
accuracy, completeness or fairness of the statements contained in the Offering
Memorandum (except as set forth in opinions (xiii) and (xiv) hereto), on the
basis of the foregoing, no facts have come to our attention which have caused us
to believe that the Offering Memorandum as of the date of the Offering
Memorandum or at the Closing Date, contained or contains any untrue statement of
a material fact or omitted or omits to state a material fact necessary in order
to make the statements therein, in the light of the circumstances under which
they were made, not misleading, except that we express no view or belief with
respect to the financial statements (including the notes thereto) and schedules
and other financial and accounting data included in the Offering Memorandum.

 

We express no opinion as to any matter other than as expressly set forth above,
and no other opinion is intended to be implied nor may be inferred herefrom. 
The opinions expressed herein are given as of the date hereof, and we undertake
no obligation hereby and disclaim any obligation to advise you of any change
after the date hereof pertaining to any matter referred to herein.  This opinion
is rendered solely for your benefit and may not be circulated, quoted, relied
upon or otherwise referred to by any other person without our written consent,
except that US Bank National Association, in its capacity as Trustee under the
Indenture, may rely on this opinion as if addressed to it.

 

 

 

Very truly yours,

 

 

 

 

 

MINTZ, LEVIN, COHN, FERRIS,

 

GLOVSKY and POPEO, P.C.

 

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