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Exhibit 10.36

SECOND AMENDMENT TO LEASE

        THIS SECOND AMENDMENT TO LEASE (this "Amendment") is executed as of
April 11, 2007, by and between ECI SHERMAN PLAZA LLC, a Delaware limited
liability company ("Landlord"), and HEMACARE CORPORATION, a California
corporation ("Tenant").

Recitals

        A.    Landlord and Tenant entered into a Lease Agreement dated
February 10, 2006 (the "Original Lease"). Under the terms of the Original Lease
Tenant leases from Landlord the following three (3) spaces in the building
located at 15350 Sherman Way, Van Nuys, California (the "Building"):

          (i)  the Initial Ground Floor Premises containing 7,178 rentable
square feet on the first (1st) floor of the Building, and the Initial Third
Floor Premises containing 4,455 rentable square feet on the third (3rd) floor of
the Building (together, the "Initial Premises"), and

         (ii)  the "Additional Premises" containing 8,011 rentable square feet
third (3rd) floor of the Building.

        B.    Landlord and Tenant entered into a First Amendment to Lease dated
as of August 17, 2006 (the "First Amendment"). Under the First Amendment,
Landlord and Tenant (i) agreed on the delivery date for the Initial Premises,
(ii) changed the Delivery Deadline for the Additional Premises, and
(iii) relocated the Initial Third Floor Premises and the Additional Premises,
all as more particularly contained therein. The Original Lease, as amended by
the First Amendment, is herein called the "Lease".

        C.    The Term of the Lease is scheduled to expire on July 31, 2017 (the
"Expiration Date").

        D.    By letter dated January 5, 2007 (the "Office Notice Letter")
Landlord delivered an "Offer Notice" in accordance with the provisions of
Article 38 of the Original Lease. The Offer Notice offered to lease to Tenant
Suite 380 containing approximately 5,735 rentable square feet, and 4,977 usable
square feet (the "Expansion Premises") in accordance with the terms contained in
such Offer Notice.

        E.    Tenant has agreed to lease the Expansion Premises, and the parties
desire to memorialize the terms of the parties' agreement.

        NOW, THEREFORE, in consideration of the foregoing recitals and the
mutual covenants contained herein, and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
parties hereto agree that the Lease is amended as follows:

        1.    Definitions.    Except as otherwise expressly provided herein to
the contrary, all capitalized terms used in this Amendment shall have the same
meaning given such terms in the Lease.

        2.    Leasing of Expansion Premises.    Commencing on June 1, 2007 (the
"Expansion Premises Commencement Date") and continuing through the entire Term,
Landlord leases to Tenant and Tenant leases from Landlord, the Expansion
Premises. The Term of the Lease for the Expansion Premises shall expire on the
Expiration Date. The parties agree that for all purposes under this Amendment,
the Expansion Premises contains 5,735 rentable square feet and 4,977 usable
square feet.

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        3.    Base Rent.    Tenant shall pay the following Base Rent for the
Expansion Premises in accordance with the provisions of the Original Lease:

Months

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  Monthly Base Rent

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June 1, 2007 - May 31, 2008:   $ 13,247.85/mo. June 1, 2008 - May 31, 2009:   $
13,764.00/mo. June 1, 2009 - May 31, 2010:   $ 14,280.15/mo. June 1, 2010 -
May 31, 2011:   $ 14,796.30/mo. June 1, 2011 - May 31, 2012:   $ 15,369.80/mo.

        During the remainder of the Term after May 31, 2012 the Base Rent for
the Expansion Premises shall be Fair Market Base Rental (as defined in
Article 43—Extension Option, in Exhibit D to the Original Lease), subject to the
following: Base Rent shall be determined as if the Term expired on May 31, 2012,
and the sixty-two (62) month period beginning June 1, 2012 would be an Extension
Period, except that (a) for the purposes of this paragraph, Tenant shall be
deemed to have given written notice of the exercise of the Extension Option on
March 1, 2012 (rather than 9 to 12 months prior to the expiration of the initial
Term), (b) the Base Rent for the Expansion Premises shall not be less than
$15,369.80 per month, (c) Landlord shall not be obligated to contribute funds
toward the cost of any remodeling, renovation, alteration or improvement work in
the Expansion Premises, and (d) for the purposes of the Expansion Premises the
Term is sixty-two (62) months, rather than five (5) years contained in
Article 43. As soon as is reasonably possible after March 1, 2012, Landlord and
Tenant shall, if requested by either party, execute and acknowledge an
instrument confirming the Base Rent payable for the Expansion Premises during
the remainder of the initial Term beginning June 1, 2012. The use of the
provisions of the Extension Option to determine Base Rent for the Expansion
Premises after May 31, 2012 in accordance with the provisions of this paragraph
shall not affect Tenant's right to exercise the Extension Option for the entire
Premises at the expiration of the initial Term.

        4.    Base Year.    The Base Year for the Expansion Premises shall be
calendar year 2007.

        5.    Tenant's Share.    Effective on the Expansion Premises
Commencement Date, Tenant's Share is hereby changed to be 20.97%.

        6.    Tenant's Services.    Tenant shall provide its own janitorial and
waste disposal service for the Expansion Premises in accordance with the
provisions of Section 9.3 of the Original Lease.

        7.    Condition of Expansion Premises.    Tenant has inspected the
Expansion Premises and has agreed to take the Expansion Premises in its current
"AS IS" condition, provided that Tenant Improvements in the Expansion Premises
shall be constructed in accordance with the provisions of the Construction Rider
attached as Exhibit B to this Amendment.

        8.    Parking.    On the Expansion Premises Commencement Date, in
addition to the number of parking spaces provided by Landlord under the
provisions contained in Article 37 Parking in Exhibit D to the Original Lease,
Landlord shall provide Tenant (a) eight (8) reserved tandem parking spaces
within four (4) rows of tandem parking adjacent to Tenant's existing tandem
parking, and (b) seventeen (17) unassigned and non-exclusive parking spaces in
the Parking Facility.

        9.    Security Deposit.    Concurrent with Tenant's execution of this
Amendment, Tenant shall deliver to Landlord (a) $15,369.80 to be added to the
Security Deposit and held by Landlord in accordance with the provisions of
Article 4 of the Original Lease, and (b) an amendment to the Letter of Credit,
increasing the Face Amount by $90,000.00 to be held by Landlord in accordance
with the provisions of Article 39 of the Original Lease, subject to the L/C
Burnoff contained in Section 39(b) of the Original Lease.

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        10.    Full Force and Effect; No Other Amendment.    The submission of
this Amendment for examination does not constitute an offer or an option for
Tenant to lease or use the Expansion Premises. This Amendment shall become
effective as a binding agreement only upon execution and delivery of a fully
executed copy by Landlord to Tenant. Except as amended by this Amendment, the
Lease has not been amended or modified; and all of the terms and provisions of
the Lease, as modified by this Amendment, remain unmodified and in full force
and effect. Landlord and Tenant hereby ratify the Lease, as amended herein. This
Amendment contains the entire agreement between Landlord and Tenant regarding
the subject matters contained herein, and except for the Lease supersedes all
prior of contemporaneous agreements, understandings, proposals and other
representations by or between Landlord and Tenant, whether written or oral, all
of which are merged herein. This Amendment shall be binding upon and inure to
the benefit of the parties hereto and their respective successors and assigns.
This Amendment is hereby executed and delivered in multiple counterparts, each
of which shall have the force and effect of an original.

        IN WITNESS WHEREOF, Landlord and Tenant have executed this Amendment as
of the day and year first above written.

LANDLORD:   TENANT:
ECI SHERMAN PLAZA LLC,
a Delaware limited liability company
 
HEMACARE CORPORATION,
a California corporation
by:
 
Embarcadero Capital Investors LP,
 
By:
/s/ Judi Irving     a Delaware limited partnership,    

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    sole member     Name: Judi Irving             Title: President & CEO
by
 
Embarcadero Capital Partners LLC,
 
By:
/s/ Robert S. Chilton     a Delaware limited liability company,    

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    its sole general partner     Name: Robert S. Chilton             Title:
EVP & CFO     by: Hamilton Partners, LP             Manager      
 
 
by:
Hamilton Ventures, Inc.,
 
 
        general partner      
 
 
by:
/s/ John Hamilton

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John Hamilton, President
 
 
 

(For corporate entities, signature by TWO corporate officers is required: one by
(x) the chairman of the board, the president, or any vice president; and the
other by (y) the secretary, any assistant secretary, the chief financial
officer, or any assistant treasurer.)

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EXHIBIT A

ATTACHED TO AND FORMING A PART OF
SECOND AMENDMENT
DATED AS OF APRIL 11, 2007
BETWEEN
ECI SHERMAN PLAZA LLC, AS LANDLORD,
AND
HEMACARE CORPORATION, AS TENANT ("AMENDMENT")

EXPANSION PREMISES

[Floor plan showing location
and configuration of Expansion Premises
to be inserted.]

    INITIALS:         Landlord   /s/ JH     Tenant   /s/ JI

Exhibit A, Page 1

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EXHIBIT B

ATTACHED TO AND FORMING A PART OF
SECOND AMENDMENT
DATED AS OF APRIL 11, 2007
BETWEEN
ECI SHERMAN PLAZA LLC, AS LANDLORD,
AND
HEMACARE CORPORATION, AS TENANT ("AMENDMENT")

CONSTRUCTION RIDER

        1.    Tenant Improvements.    Tenant shall, with reasonable diligence
through a contractor (the "Contractor") approved by Landlord pursuant to the
provisions of this Section 1, construct and install in the Expansion Premises
the improvements and fixtures provided for in this Construction Rider ("Tenant
Improvements"). Tenant hereby designates Bob Chilton as the individual
authorized to act as Tenant's representative with respect to all approvals,
directions and authorizations pursuant to this Tenant Work Letter.

        Prior to the contract for the Tenant Improvements being put out to bid,
Landlord and Tenant may each add the names of two (2) contractors to the bid
list for construction of the Tenant Improvements. Landlord shall have the
reasonable right to review and approve each contractor on the bid list based
upon such contractor's qualifications, including (a) quality of work,
(b) creditworthiness, (c) experience, and (d) references. Landlord approves
Warner Constructors, Inc. as the Contractor.

        1.1.    Plans.    The Tenant Improvements shall be constructed
substantially as shown on a conceptual space plan for the Expansion Premises to
be approved in writing by Landlord and prepared by Wolcott Architecture
Interiors ("Space Planner") as the space planner for the Expansion Premises
("Space Plan"). Landlord shall approve or disapprove the Space Plan by written
notice given to Tenant within ten (10) days after receipt of the Space Plan. If
Landlord disapproves a Space Plan, Landlord shall return the Space Plan to
Tenant with a statement of Landlord's reasons for disapproval, or specifying any
required corrections and/or revisions. Landlord shall approve or disapprove of
any revisions to the Space Plan by written notice given to Tenant within five
(5) business days after receipt of such revisions. This procedure shall be
repeated until Landlord approves the Space Plan.

        After approval of the Space Plan, the Space Planner will prepare and
deliver to Landlord and Tenant detailed plans and specifications sufficient to
permit the construction of the Tenant Improvements by Tenant's Contractor in
accordance with the Space Plan and the cost agreed upon by Landlord and Tenant
for the total cost of the Tenant Improvements ("Construction Documents"). The
Tenant Improvements, as shown in the Construction Documents shall include
Building standard entry doors and hardware. Landlord shall respond to the
Construction Documents within ten (10) days after receipt thereof, specifying
any changes or modifications Landlord requires in the Construction Documents.
Landlord shall not unreasonably require changes or modifications or withhold its
approval of the Construction Documents; provided, however, Landlord may, in its
sole and absolute discretion, require changes or modifications or withhold its
approval of the Construction Documents if (1) the Tenant Improvements will
affect the Base Building or the Building Systems, (2) the Tenant Improvements
will alter or be visible from the exterior of the Expansion Premises, (3) any
elements of the Tenant Improvements are inconsistent with Landlord's standard
protocols or rules for construction in the Building, (4) any element of the
Tenant Improvements fails to comply with any applicable Law, or (5) the cost of
removing the Tenant Improvements at the end of the Term would be excessive in
Landlord's reasonable estimation. Following Landlord's required changes or
modifications, the Space Planner will then revise the Construction Documents and
resubmit them to Landlord for its approval.

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Landlord shall approve or disapprove the same within ten (10) days after
receipt. The revised Construction Documents, as finally approved by Tenant and
Landlord, are hereinafter referred to as the "Final Construction Documents".

        1.2.    Construction.    Following approval by Landlord and Tenant of
the Final Construction Documents, Tenant shall cause the Contractor to promptly
commence and diligently proceed to cause the Tenant Improvements to be
constructed in accordance with Landlord's standard protocols and rules for
construction in the Building, and Article 6 of the Original Lease. Prior to
commencement of construction, Tenant shall provide evidence satisfactory to
Landlord that Tenant has obtained the insurance required to be maintained by
Tenant pursuant to the Original Lease. Tenant shall provide Landlord with at
least fifteen (15) days' prior written notice of the date for its commencement
of construction of the Tenant Improvements in the Expansion Premisees, in order
to permit Landlord to post, file, and record such Notices of Nonresponsibility
and other instruments as may be necessary to protect Landlord and its property
from claims by contractors for construction costs that are to be paid by Tenant.
Tenant will obtain, comply with and keep in effect all consents, permits and
approvals required by any governmental authorities (collectively, "Permits")
that relate to or are necessary for the lawful construction of the Tenant
Improvements. At the time Final Construction Documents are ready for submission
to any governmental authorities for review in connection with the Permits,
Landlord shall be notified in writing by Tenant. Prior to applying for any of
the Permits or submitting documentation in connection therewith, Tenant shall
provide Landlord with the opportunity to review and approve any Permit
applications Tenant intends to file. Tenant shall further provide Landlord with
any comments to any submitted plan documents made by any governmental authority
immediately upon Tenant's receipt of same (all of which comments shall be
subject to the provisions of Section 1.4 below), and copies of all Permits
required for construction of the Tenant Improvements upon issuance. Tenant shall
comply with all applicable Laws and with all recorded restrictions affecting the
Property. Landlord shall have the right to suspend any construction activity by
Tenant that detracts from harmonious labor relations at the Property.

        1.3.    Cost of Tenant Improvements.    

        1.3.1.    Expansion Improvement Allowance; Supervision Fee.    Landlord
shall contribute up to Seventy-Four Thousand Six Hundred Fifty-Five and 00/100
Dollars ($74,655.00) (the "Expansion Improvement Allowance") toward the actual
costs of the design (including preparation of the Space Plan and Construction
Documents), construction and installation of the Tenant Improvements in the
Expansion Premises incurred and paid by Tenant to third parties (including a
project manager) and the payment of Landlord's supervision fee in the total
amount of $7,500.00 ("Supervision Fee") for constructing the Tenant
Improvements. The balance, if any, of the cost of the Tenant Improvements shall
be paid by Tenant directly to applicable third parties. Landlord's Supervision
Fee shall be paid out of the Expansion Improvement Allowance prior to
commencement of construction of the Tenant Improvements. Neither Tenant nor
Tenant's contractors shall be required to pay for elevator use, freight elevator
use, loading access, or utilities during planning and construction of the Tenant
Improvements.

        1.3.2.    Disbursement of Expansion Improvement Allowance.    Landlord
shall disburse the Expansion Improvement Allowance to Tenant as the construction
of the Tenant Improvements progresses in the Expansion Premises, as follows: On
or before the tenth (10th) day of each month, Tenant shall deliver to Landlord
an application for reimbursement, accompanied by documentary evidence as
reasonably required by Landlord (including, at a minimum, copies of the paid
invoices and unconditional mechanics' lien waivers reasonably required by
Landlord and signed by the applicable party) of the costs incurred by Tenant for
the design and construction of the Tenant Improvements since the last
application for reimbursement. Within

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thirty (30) days after Landlord's receipt of such an application for
reimbursement, Landlord shall pay to Tenant a pro rata share of such application
determined by multiplying the amount of such application by a fraction, the
numerator of which is the Expansion Improvement Allowance and the denominator of
which is the greater of (1) the total estimated cost of the Tenant Improvements,
including all professional fees and services, and all licensing and permit fees,
or (2) the Expansion Improvement Allowance; provided, however that after making
the foregoing calculation Landlord shall retain an amount equal to ten percent
(10%) of Landlord's pro rata share of each application (the "Landlord
Retention"), which Landlord Retention shall be released pursuant to the
provisions of Section 1.3.3 below.

        1.3.3.    Evidence of Completion.    Within thirty (30) days following
substantial completion of the Tenant Improvements in the Expansion Premises
(which shall mean completion of the Tenant Improvements and receipt of permit
sign-offs sufficient to permit legal occupancy of the Expansion Premises,
subject only to correction of punch-list items that do not affect safe occupancy
of the Expansion Premises), Tenant shall submit to Landlord:

        (a)   A statement of Tenant's final construction costs, together with
receipted evidence showing payment thereof, reasonably satisfactory to Landlord,
and, to the extent not previously delivered, fully executed and notarized
unconditional lien releases in the form prescribed by law from Tenant's
contractors, copies of all detailed, final invoices from Tenant's contractors
related to the Tenant Improvements.

        (b)   All Permits and other documents issued by any governmental
authority in connection with the approval and completion of the Tenant
Improvements, and all evidence reasonably available showing compliance with all
applicable Laws of any and all governmental authorities having jurisdiction over
the Expansion Premises, including, without limitation, a certificate of
occupancy or its equivalent such as duly signed-off job cards, building permit
sign-offs, and/or other appropriate authorization for physical occupancy of the
Expansion Premises.

        (c)   A valid certificate of substantial completion executed by Tenant's
architect confirming that the Tenant Improvements have been substantially
completed in accordance with the Final Construction Documents, subject to
punch-list items to be completed by Tenant's contractors after the Expansion
Premises Commencement Date.

        (d)   A written certificate, subscribed and sworn before a Notary
Public, from Tenant's general Contractor as follows: "There are no known
mechanics' or materialmen's liens outstanding, all due and payable bills with
respect to the Tenant Improvements have been paid, and there is no known basis
for the filing of any mechanics' or materialmen's liens against the Expansion
Premises, the Building or the Property, and, to the best of our knowledge,
waivers from all subcontractors and materialmen are valid and constitute an
effective waiver of lien under applicable law."

        (e)   Copies of all of Tenant's contractors' warranties.

        (f)    A reproducible copy of the "as built" drawings of the Tenant
Improvements.

        (g)   Any other items reasonably requested by Landlord.

Within thirty (30) days after receipt of all of the above, Landlord shall make
its disbursement of the final ten percent (10%) of the Expansion Improvement
Allowance (or so much of the Expansion Improvement Allowance that has not yet
been paid by Landlord, but in no event to exceed, in the aggregate, the actual
cost of the design and construction of the Tenant Improvements) to Tenant or
Tenant's contractors, as applicable, as required above.

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Any portion of the Expansion Improvement Allowance not used in the design,
construction and installation of the Tenant Improvements shall be retained by
Landlord, and Tenant shall have no right to receive or apply toward Tenant's
rental obligations any portion of the Expansion Improvement Allowance not
actually used. Further, Landlord shall only be obligated to pay the Expansion
Improvement Allowance (or portions thereof) to the extent Tenant has incurred
the costs of the design, construction and installation of the Tenant
Improvements within the first twelve (12) months after the Expansion Premises
Commencement Date.

        1.4.    Governmentally-Required Changes.    Tenant acknowledges that,
pursuant to all applicable Laws and regulations (including, without limitation,
Title III of the Americans with Disabilities Act of 1990 and the Building Code
of the City of Los Angeles, California), the construction of the Tenant
Improvements in the Expansion Premises may result in additional
governmentally-required alterations or improvements to the Expansion Premises or
the Building. If the proposed design and construction of the Tenant Improvements
results in any such governmentally-required alterations or improvements being
imposed as a condition to the issuance of applicable permits or approvals, then
Tenant shall be solely responsible for all costs and expenses relating to such
additional governmentally-required alterations and improvements (which shall be
constructed by Landlord); provided, however, that if the performance of such
governmentally-required alterations or improvements can be avoided by modifying
the cost, design or manner of construction of the Tenant Improvements, then
Tenant may elect to modify the Tenant Improvements in accordance with the
provisions of this Tenant Work Letter (including, without limitation,
Section 1.5 below). Landlord shall notify Tenant of any such required
alterations or improvements promptly after Landlord is notified of the same.

        Landlord shall be responsible for the costs required in the Expansion
Premises or the common areas by any applicable governmental agency to comply
with the Americans with Disabilities Act as it is applied and interpreted as of
the date of this Amendment, including repairs or alterations required to comply
with Laws generally applicable to the use of the Expansion Premises as office
space and not required or caused by Tenant's particular use or activities,
except to the extent the cost of complying is due to the acts or omissions of
Tenant, and except any costs of complying with Laws not in effect as of the date
of this Amendment or as any Laws in effect as of the date of this Amendment may
be amended, changed, added to, interpreted or re-interpreted by applicable
governmental authority or court decision, or administrative ruling subsequent to
the date of this Amendment. Tenant shall be responsible for the costs required
in the Expansion Premises and the common areas by any applicable governmental
agency to comply with the Americans with Disabilities Act, and which are
required or caused by Tenant's particular use or activities.

        1.5.    Changes.    If Tenant desires any change, addition or alteration
in or to the Space Plan or any Construction Documents ("Changes"), Tenant shall
cause additional Construction Documents implementing such Changes to be
prepared. All Changes shall be subject to Landlord's approval as set forth in
Section 1.1 of this Tenant Work Letter. Tenant shall be solely responsible for
all costs resulting from any Changes.

        1.6    Notice of Completion.    Upon completion of the Tenant
Improvements, Tenant agrees to cause a Notice of Completion to be recorded in
the office of the Recorder of the County of Los Angeles in accordance with
Section 3093 of the Civil Code of the State of California or any successor
statute.

        2.    Ownership of Tenant Improvements.    All Tenant Improvements shall
become a part of the Expansion Premises, shall be the property of Landlord and,
subject to the provisions of the Lease, shall be surrendered by Tenant with the
Expansion Premises, without any compensation to Tenant, at the expiration or
termination of the Lease in accordance with the provisions of the Lease.

    INITIALS:         Landlord   /s/ JH     Tenant   /s/ JI

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QuickLinks

Exhibit 10.36

SECOND AMENDMENT TO LEASE
Recitals