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Exhibit 10.5

AMENDMENT TO ASSIGNMNENT OF DEPOSIT ACCOUNT

        This Amendment To Assignment of Deposit Account (this "Amendment") is
made as of July 23, 2002, by and between Maxim Pharmaceuticals, Inc. ("Pledgor")
and Silicon Valley Bank ("Lender").

RECITALS

        A.    Kurt R. Gehlsen ("Borrower") has obtained credit from Bank in the
original principal amount of $750,000.00 (the "Loan"). The Loan has been
increased to $1,260,000.00 pursuant to Change in Terms Agreement dated July 23,
2002. As security for repayment of the Loan and for all indebtedness owing by
Borrower to Lender, Pledgor has granted to Lender a security interest in the
Certificate of Deposit Account Number XXXXXX3215, pursuant to the Assignment of
Deposit Account agreement dated April 11, 2001 (the "Pledge Agreement").

        B.    Grantor and Lender desire to modify the Pledge Agreement, in
accordance with the terms of this Amendment.

        NOW THEREFORE, Borrower and Lender agree as follows:

        1.    The term Collateral is hereby amended in part to mean Certificate
of Deposit Account Number XXXXXX3215 issued by Lender in an amount not less than
$1,800,000.00 with respect to Borrower's Loan in the principal amount of
$1,260,000.

        2.    Unless otherwise defined, all capitalized terms in this Amendment
shall have the meanings assigned in the Pledge Agreement. Except as amended, the
Pledge Agreement remains in full force and effect.

        3.    This Amendment may be executed in two or more counterparts, each
of which shall be deemed an original, but all of which together shall constitute
one instrument.

        4.    This Amendment amends certain terms of the Pledge Agreement.
Except as amended hereby, the Pledge Agreement remains in full force and effect.
This Amendment, together with the Pledge Agreement and any documents executed in
connection with the Pledge Agreement, constitute the entire agreement of the
parties with respect to the subject matter hereof, and supersede all prior
agreements and negotiations.

        IN WITNESS WHEREOF, the undersigned have executed this Amendment as of
the first date above written.

Pledgor:   Lender:
MAXIM PHARMACEUTICALS, INC.
 
SILICON VALLEY BANK
By:
 
/s/  LARRY G. STAMBAUGH      
 
By:
 
/s/  DEE HOUSE      
Name:
 
Larry G. Stambaugh
 
Name:
 
Dee House
Title:
 
President and CEO
 
Title:
 
Director of Private Banking

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Exhibit 10.5

AMENDMENT TO ASSIGNMNENT OF DEPOSIT ACCOUNT