EXHIBIT 10.132

 

CONFIDENTIAL TREATMENT REQUESTED. CONFIDENTIAL PORTIONS OF THIS DOCUMENT HAVE
BEEN REDACTED AND HAVE BEEN FILED SEPARATELY WITH THE U.S. SECURITIES AND
EXCHANGE COMMISSION

 

LICENSE AGREEMENT

 

by and between

 

AVENTIS PHARMA SA

 

and

 

INDEVUS PHARMACEUTICALS, INC

 

--------------------------------------------------------------------------------

THIS LICENSE AGREEMENT effective as of April 18, 2003 (“Effective Date”), by and
between AVENTIS PHARMA SA (“AVENTIS”), a corporation organized and existing
under the laws of France and having its principal office at 20 avenue Raymond
Aron, 92165 Antony, France (“AVENTIS”) and INDEVUS PHARMACEUTICALS INC., a
corporation organized and existing under the laws of the State of Delaware and
having its principal office at 99 Hayden Avenue, Suite 200, Lexington,
Massachusetts 02421, United States (“INDEVUS”).

 

W I T N E S S E T H:

 

WHEREAS, AVENTIS is the owner of AVENTIS Intellectual Property, as defined
herein and;

 

WHEREAS, INDEVUS desires to obtain exclusive license rights, with a right to
grant sublicenses, under the AVENTIS Intellectual Property, and AVENTIS desires
to grant such license to INDEVUS, upon the terms and conditions set forth
herein; and

 

NOW, THEREFORE, in consideration of the foregoing premises and the mutual
covenants herein contained, and for other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the Parties hereby
agree as follows:

 

ARTICLE I

DEFINITIONS

 

Unless specifically set forth to the contrary herein, the following terms, where
used with an initial capital letter, and where used in the singular or plural,
shall have the respective meanings set forth below:

 

1.1 “Act” shall mean the Federal Food Drug and Cosmetic Act of 1934, and the
rules and regulations promulgated thereunder, or any successor act, as the same
shall be in effect from time to time.

 

1.2 “Affiliate” shall mean (i) any corporation or business entity of which more
than fifty percent (50%) of the securities or other ownership interests
representing the equity, the voting stock or general partnership interest are
owned, controlled or held, directly or indirectly, by a Party; (ii) any
corporation or business entity which, directly or indirectly, owns, controls or
holds more than fifty percent (50%) (or the maximum ownership interest permitted
by law) of the securities or other ownership interests representing the equity,
voting stock or general partnership interest of a Party or (iii) any corporation
or business entity of which a Party has the right to acquire, directly or
indirectly, at least fifty percent (50%) of the securities or other ownership
interests representing the equity, voting stock or general partnership interest
thereof.

 

1.3 “AVENTIS Intellectual Property” shall mean the AVENTIS Patent Assets and
AVENTIS Know-How.

 

2

--------------------------------------------------------------------------------

1.4 “AVENTIS Know-How” shall mean any and all information and materials,
including but not limited to, discoveries, Improvements, information, processes,
formulae, data, inventions (whether patentable or not), invention disclosures,
know-how and trade secrets, patentable or otherwise, that relate to Compound or
Product, including without limitation, all chemical, pharmaceutical,
toxicological, biochemical, and biological, technical and non technical data,
and information relating to the results of tests, assays, methods, and
processes, and specifications and/or other documents containing information and
related data, and any preclinical, clinical, assay control, manufacturing,
regulatory, and any other data or information, submitted, or required to be
submitted, to any Regulatory Authority in connection with any regulatory filing
or application relating to Compound or Product, Chemistry, Manufacturing and
Control (CMC) data, or similar data used or useful for the development,
manufacturing and/or regulatory approval of Compound or Product that are or
become at any time during the Term of this Agreement owned or controlled by
AVENTIS and as to which AVENTIS has the right to license or sublicense to
another party including such rights which AVENTIS may have to information
developed by Third Parties.

 

1.5 “AVENTIS Patent Assets” shall mean the United States patents and patent
applications and any foreign counterparts thereof listed in Schedule 1.5 hereto
which as of the Effective Date are owned by AVENTIS or which AVENTIS has or
acquires rights from a Third Party, and relate to Compound, Product or any
Improvement, including but not limited to methods of their development,
manufacture, or use, or otherwise relate to AVENTIS Know-How, including all
certificates of invention and applications for certificates of invention and
substitutions, divisions, continuations, continuations-in-part, patents issuing
thereon or reissues or reexaminations thereof, supplementary protection
certificates or the like of any such patents and patent applications.

 

1.6 “Business Day(s)” shall mean any day that is not a Saturday or a Sunday or a
day on which the New York Stock Exchange is closed or a day that is a Bank
Holiday in France (which days are set forth on Schedule 1.6 hereto).

 

1.7 “Calendar Quarter” shall mean the respective periods of three (3)
consecutive calendar months ending on March 31, June 30, September 30 and
December 31.

 

1.8 “Calendar Year” shall mean each successive period of twelve (12) months
commencing on January 1 and ending on December 31.

 

1.9 “Centralized Procedure” shall mean the European Union Centralized Procedure
for marketing authorization in accordance with Council Regulation n° 2309/93 of
July 22, 1993 or any successor regulations.

 

1.10 “CFR” shall mean the United States Code of Federal Regulations.

 

1.11 “cGMP” shall mean current applicable good manufacturing practices as
defined in regulations promulgated by the FDA under the Act relating to the
formulation, manufacture, testing prior to delivery, storage and delivery of
Compound or Product.

 

1.12 “Committee” shall mean the steering committee described in Section 3.3.

 

3

--------------------------------------------------------------------------------

1.13 “Compulsory License” shall mean any agreement under which any governmental
body in any country in the Territory grants or compels INDEVUS to grant, license
or marketing rights for Product to any Third Party.

 

1.14 “Compound” shall mean the chemical compound known under the International
Non-proprietary name aminocandin and the code name HMR-3270 and diagrammed on
Schedule 1.14 hereto, and any other compounds disclosed or covered or included
in the AVENTIS Patent Assets or any compound that is part of the aminocandin
family of compounds or any derivative, homolog, or analog of any of the
foregoing, and any isomer, salt, hydrate, solvate, amide, ester, metabolite, or
prodrug of any of the foregoing that exists and is owned or controlled by
AVENTIS as of the Effective Date.

 

1.15 “Development Plan” shall mean the plan related to the conduct of the
Development Program, as described in Section 3.3.5.

 

1.16 “Development Program” shall mean those activities to be undertaken by
INDEVUS or its designee (or, to the extent specifically set forth in this
Agreement, AVENTIS) with respect to Compound or Product which are devoted to the
evaluation of a potential pharmaceutical product in clinical trials, and/or the
conduct of any other activities or studies directed toward obtaining Regulatory
Approval of Product.

 

1.17 “Dominating Patent” shall mean an unexpired patent which has not been
invalidated by a court or other governmental agency of competent jurisdiction
which is owned by a Third Party and which INDEVUS or its sublicensees reasonably
believe they have no alternative to obtaining a royalty-bearing license under
such patent in order to commercialize a Product under this Agreement without
infringing such patent.

 

1.18 “Effective Date” shall mean the date first above written.

 

1.19 “EMEA” means the European Agency for the Evaluation of Medicinal Products
based in London (UK), as established by Council Regulation n° 2309/93 of July
22, 1993, as subsequently amended by Commission Regulation 649/98 of March 23,
1998.

 

1.20 “End of Phase 2 Meeting” shall mean the first end of Phase 2 meeting with
the FDA, as defined in 21 CFR Section 312.47, intended to determine the safety
of proceeding to Phase 3, evaluate the Phase 3 plan and protocols and identify
any additional information necessary to support an NDA for Product.

 

1.21 “FDA” shall mean the United States Food and Drug Administration.

 

1.22 “First Commercial Sale” shall mean the first sale of Product in any country
by INDEVUS, its Affiliate or its sublicensee(s), for end use or consumption,
after all required Regulatory Approvals have been granted by the governing
health authority of such country.

 

1.23 “GAAP” shall mean generally accepted accounting principles in the United
States.

 

1.24 “Generic Competition” in any particular country shall exist or commence on
the earlier of (i) where IMS or IMS- equivalent data is available, the first
date on which Generic Drugs

 

4

--------------------------------------------------------------------------------

achieve a market share in one Calendar Quarter of twenty percent (20%) or
greater of the total prescriptions for Product in such country (as so shown by
the average of the monthly IMS (or IMS-equivalent) data for such prescriptions)
or (ii) the first date on which there are two Generic Drugs available in one
Calendar Quarter in such country.

 

1.25 “Generic Drug(s)” shall mean any product containing compound that (i) is
defined in a particular country in the Territory as a generic drug to the
Compound by applicable legal texts or governing health authorities in such
country, or (ii) can be substituted for the Compound by a pharmacy, other than a
product introduced in such country by INDEVUS, its Affiliates or INDEVUS
Sublicensees.

 

1.26 “Improvement” shall mean any and all improvements and enhancements,
patentable or otherwise, related to the Compound or Product including, without
limitation, in the manufacture, formulation, ingredients, preparation,
presentation, means of delivery or administration, dosage, indication, use or
packaging of Compound or Product.

 

1.27 “IND” shall mean an investigational new drug application and any amendments
thereto relating to the use of Compound or Product in the United States or the
equivalent application in any other regulatory jurisdiction in the Territory,
the filing of which is necessary to commence clinical testing of pharmaceutical
products in humans.

 

1.28 “INDEVUS Know-How” shall mean any and all information and materials,
including but not limited to, discoveries, Improvements, information, processes,
formulae, data, inventions (whether patentable or not), invention disclosures,
know-how and trade secrets, patentable or otherwise, that relate to Compound or
Product, including without limitation, all chemical, pharmaceutical,
toxicological, biochemical, and biological, technical and non technical data,
and information relating to the results of tests, assays, methods, and
processes, and specifications and/or other documents containing information and
related data, and any preclinical, clinical, assay control, manufacturing,
regulatory, and any other data or information (including without limitation any
Drug Master Files (DMFs) if any, Chemistry, Manufacturing and Control (CMC) data
or similar data) used or useful for the development, manufacturing, regulatory
filing or application and/or regulatory approval of Compound or Product that as
a result of the Development Program become owned or controlled by INDEVUS and as
to which INDEVUS has the right to license or sublicense to another party
including such rights which INDEVUS may have to information developed by Third
Parties.

 

1.29 “INDEVUS Patent Assets” shall mean the United States patents and patent
applications and any counterparts thereof which may be filed in other countries
which at any time during the term of this Agreement are owned by INDEVUS or
which INDEVUS has or acquires rights from a Third Party, and relate to Compound,
Product or any Improvement, including but not limited to methods of their
development, manufacture, or use, or otherwise relate to INDEVUS Know-How,
including all certificates of invention and applications for certificates of
invention, substitutions, divisions, continuations, continuations-in-part,
patents issuing thereon or reissues or reexaminations thereof and any and all
foreign patents and patent applications corresponding thereto, supplementary
protection certificates or the like of any such patents and patent applications,
including Program Information and Inventions and patents and patent applications
resulting from the Development Program.

 

5

--------------------------------------------------------------------------------

1.30 “NDA” shall mean a new drug application or other submission filed with the
applicable Regulatory Authority in any regulatory jurisdiction in the Territory
to obtain Regulatory Approval of a Product in such regulatory jurisdiction, and
any amendments and supplements thereto.

 

1.31 “Net Sales” shall mean the gross amount invoiced by INDEVUS or its
Affiliates or its sublicensees for sales of Product in the Territory commencing
respectively on the date of First Commercial Sale in each country in the
Territory, after deducting the following:

 

  (i)   trade, cash and quantity discounts not already reflected in the amount
invoiced;

 

  (ii)   amounts repaid or credited for Product returns, including for
rejections, or spoilage or recalls

 

  (iii)   rebates and chargebacks;

 

  (iv)   retroactive price reductions;

 

  (v)   sales or excise taxes, VAT or other taxes, custom duties, and other
governmental charges and transportation and insurance charges to the extent
included in the invoiced price; and if assessed directly against the seller, to
the extent actually paid;

 

  (vi)   compulsory payments and rebates directly related to sales of Product to
any governmental or regulatory authority in respect of any state or federal
Medicare, Medicaid or similar programs in any country of the Territory; and

 

  (vii)   write offs for bad debts to the extent resulting exclusively from
unpaid invoices of Products.

 

Sales or other transfers between INDEVUS and its Affiliates and/or its
sublicensees shall be excluded from the computation of Net Sales and no payments
will be payable on such sales or transfers except where such Affiliates or
sublicensees are end users, but Net Sales shall include the subsequent sales to
Third Parties by such Affiliates or sublicensees.

 

1.32 “Nucleus” shall mean deacylmulundocandin, the starting material for the
manufacture of the Compound, obtained by biochemistry through a biosynthesis
from an Aspergillus strain, the first step of which leads to deoxymulundocandin
and the second step of which leads to deacylmulundocandin.

 

1.33 “Over-the Counter Product” shall mean a Product that is not a Prescription
Product.

 

1.34 “Party” shall mean AVENTIS or INDEVUS, and “Parties” shall mean AVENTIS and
INDEVUS.

 

6

--------------------------------------------------------------------------------

1.35 “Phase 1 Multiple Dose Clinical Trial” shall mean the first clinical trial
in which multiple dosage ranges of Product are initially introduced into humans.

 

1.36 “Phase 2 Clinical Trial” shall mean the first clinical trial of Product in
patients with an indicated fungal infection that is designed to show safety and
efficacy of Product for its intended use.

 

1.37 “Phase 3 Clinical Trial” shall mean the first clinical trial conducted
after an End of Phase 2 Meeting and conducted on a sufficient number of patients
that is designed to establish that Product is safe and efficacious for its
intended use.

 

1.38 “Prescription Product” shall mean a Product subject to the provisions of
Section 503 (b) 1 (B) of the Act.

 

1.39 “Product” shall mean any product in final form (or where the context so
indicates, the product being tested in clinical trials)which contains Compound
as at least one of the therapeutically active ingredients.

 

1.40 “Proprietary Information” shall mean any and all scientific, clinical,
regulatory, marketing, financial and commercial information or data, whether
communicated in writing, orally or by any other means, which is owned and under
the protection of one Party and is being provided by that Party to the other
Party in connection with this Agreement.

 

1.41 “Regulatory Approval” shall mean all authorizations and approvals
(including pricing and reimbursement approvals where required for marketing), of
all regional, federal, state or local agencies, departments, bureaus or other
governmental entities, necessary for the manufacture, use, storage, import,
export, transport and sale of Product in a jurisdiction.

 

1.42 “Regulatory Authority” shall mean the FDA in the U.S., and any body in the
European Union and any health regulatory authority(ies) in any country(ies) in
the Territory that is equivalent to the FDA and holds responsibility for
granting Regulatory Approval for a Product in such country(ies), and any
successor(s) thereto having substantially the same functions.

 

1.43 “Right of First Negotiation” shall have the meaning set forth in Section
2.4 of this Agreement.

 

1.44 “Royalty Year” shall mean, (i) for the year in which the First Commercial
Sale occurs (the “First Royalty Year”), the period commencing with the first day
of the Calendar Quarter in which the First Commercial Sale occurs and expiring
on the last day of the Calendar Year in which the First Commercial Sale occurs
and (ii) for each subsequent year, each successive Calendar Year.

 

1.45 “Sublicense Royalty Payments” shall mean royalty or other payments based on
Net Sales of Product that are received by INDEVUS from a sublicensee of any of
the rights granted by AVENTIS to INDEVUS under Section 2.1 of this Agreement, as
consideration for the grant of such sublicense.

 

7

--------------------------------------------------------------------------------

1.46 “Specifications” shall mean the written methods, formulae, procedures,
specifications, tests (and testing protocols) and standards pertaining to the
Nucleus as attached hereto as Schedule 1.46 and as they may be modified from
time to time by mutual written agreement of the Parties and consistent with the
Regulatory Approval.

 

1.47 “Territory” shall mean all of the countries in the world.

 

1.48 “Third Party(ies)” shall mean a person or entity who or which is neither a
Party nor an Affiliate of a Party.

 

1.49 “Valid Claim” shall mean a claim of an issued and unexpired patent included
within the AVENTIS Patent Assets, which has not been revoked or held
unenforceable or invalid by a decision of a court or other governmental agency
of competent jurisdiction, and which has not been disclaimed, denied or admitted
to be invalid or unenforceable through reissue or disclaimer.

 

ARTICLE II

LICENSES; SUBLICENSES

 

2.1 License Grant. In consideration of and subject to the terms and conditions
of this Agreement, AVENTIS hereby grants to INDEVUS an exclusive (even as to
AVENTIS) license under AVENTIS Intellectual Property, including the right to
grant sublicenses (subject to Section 2.3 below), to develop, make, have made,
use, import, offer for sale, market, commercialize, distribute, sell or
otherwise dispose of Compound and Product for all uses in the Territory.
Notwithstanding the foregoing, it is understood and acknowledged that (i)
provided that AVENTIS is manufacturing the Nucleus in accordance with Section
3.8 (a) and the supply agreement referred to therein, the rights hereby granted
shall not extend to the right to manufacture the Nucleus; and (ii) to the extent
any part of the AVENTIS Intellectual Property falls outside the scope of the
license granted to INDEVUS hereunder, AVENTIS shall retain such right and shall
be free to operate under such right.

 

2.2 Improvement by INDEVUS. All rights and title to and interest in any
Improvement conceived, developed, discovered and/or reduced to practice solely
by INDEVUS in connection with the license granted under Section 2.1 above or
INDEVUS’ activities hereunder shall be vested solely in INDEVUS.

 

2.3 Sublicenses. INDEVUS shall have the right to grant sublicenses to Affiliates
or, subject to the Right of First Negotiation set forth in Section 2.4 below,
any Third Party to develop, make, have made, use, import, offer for sale,
market, commercialize, distribute and sell and otherwise dispose of Compound or
Product in the Territory; provided, however, that (i) INDEVUS shall not have the
right to grant any such sublicenses to a Third Party prior to the completion of
Phase 1 studies necessary to commence the first Phase 2 Clinical Trial and (ii)
INDEVUS shall advise AVENTIS of any proposed sublicense with a Third Party and
give due consideration to AVENTIS’ reasonable comments thereto. In the event of
a sublicense by INDEVUS to a Third Party, the provisions of Section 5.3.2 of
this Agreement shall be applicable. Any such sublicense shall be subject to the
terms and conditions of this Agreement,

 

8

--------------------------------------------------------------------------------

and INDEVUS shall be responsible to AVENTIS for any non- performance by the
sublicensee of INDEVUS’ obligations under this Agreement that are assumed by the
sublicensee.

 

2.4 Right of First Negotiation. INDEVUS shall grant AVENTIS a right of first
negotiation (the “Right of First Negotiation”) to obtain from INDEVUS a
Sublicense Opportunity (as defined below), on and subject to the following terms
and conditions:

 

2.4.1. In the event INDEVUS intends to begin negotiations relating to a
sublicense of Compound or Product (a “Sublicense Opportunity”), INDEVUS shall
give written notice of such intention to AVENTIS (the “Commencement Notice”).
The Commencement Notice shall include a summary of any INDEVUS Know-How
generated pursuant to the Development Program that has not been previously
presented at a Committee meeting.

 

2.4.2. AVENTIS shall have the right to exercise the Right of First Negotiation
by delivery to INDEVUS of a written notice (the “AVENTIS Notice”) within [*]
days after the date of receipt of the Commencement Notice stating that it has a
bona fide interest in entering into such Sublicense Opportunity and including a
proposal by AVENTIS of the terms thereof.

 

2.4.3. If AVENTIS exercises the Right of First Negotiation pursuant to Section
2.4.2, INDEVUS and AVENTIS shall engage in exclusive, good faith negotiations to
enter into an agreement relating to the Sublicense Opportunity on mutually
acceptable terms and conditions within [*] days of the date of receipt by
INDEVUS of the AVENTIS Notice (the “Negotiation Period”). Such agreement would
include the grant by INDEVUS to AVENTIS of an exclusive or non-exclusive
sublicense under (i) the AVENTIS Intellectual Property and (ii) the INDEVUS
Patent Assets and INDEVUS Know-How, to develop, make, have made, use, import,
offer for sale, market, commercialize, distribute and sell and otherwise dispose
of Compound and Product for such uses and in such countries in the Territory,
and on such terms and conditions, as may be negotiated in good faith and
mutually agreed to by the Parties.

 

2.4.4. In the event that (i) INDEVUS has not received the AVENTIS Notice in
accordance with Section 2.4.2 within [*] days after the date of receipt of the
Commencement Notice by AVENTIS, or (ii) the AVENTIS Notice states that AVENTIS
does not intend to exercise its Right of First Negotiation, or (iii) AVENTIS
exercises the Right of First Negotiation but the Parties are unable to reach
agreement prior to expiration of the Negotiation Period, the Right of First
Negotiation shall expire and INDEVUS shall be free to enter into a transaction
relating to such Sublicense Opportunity with any Third Party; provided, however,
that INDEVUS shall not enter into a Sublicense Opportunity with a Third Party
for a period of [*] days after expiration of the Negotiation Period if the terms
of the sublicense with such Third Party are, in the aggregate, less favorable to
INDEVUS than the terms agreed to by AVENTIS in the negotiations pursuant to
Section 2.4.3.

 

*CONFIDENTIAL TREATMENT REQUESTED

 

9

--------------------------------------------------------------------------------

ARTICLE III

DEVELOPMENT AND COMMERCIALIZATION

 

3.1 Exchange of Information.

 

3.1.1. Subject to subsection 3.1.2, AVENTIS shall disclose to INDEVUS in the
language in which they are available (except that all information required to be
submitted to any Regulatory Authority in connection with any Regulatory Approval
shall be disclosed by AVENTIS to INDEVUS in English) and in writing, in
electronic format, where available, and hard copies (or, upon INDEVUS’ request,
originals), (a) within ten (10) Business Days after execution of this Agreement,
all AVENTIS Intellectual Property not previously available or made available to
INDEVUS and (b) on an ongoing basis throughout the term of this Agreement, and
in addition to the other communications required under this Agreement, all
AVENTIS Intellectual Property, and any and all additions or revisions thereto,
provided, however, that AVENTIS shall not be required to write any CMC
documentation that does not exist as of the date of this Agreement.

 

3.1.2. As long as AVENTIS manufactures and supplies or, in accordance with the
provisions of Section 3.8 (a) hereof, AVENTIS’ permitted assignee manufactures
and supplies, INDEVUS with Nucleus, in each case in accordance with the supply
agreement contemplated by Section 3.8 (a) hereof, AVENTIS shall not be required
to disclose or transfer to INDEVUS that portion of the AVENTIS Intellectual
Property specifically covering the manufacturing process for the Nucleus,
provided, however, that such information and AVENTIS Intellectual Property shall
at all times be included in the Drug Master File relating to Compound and/or
Product and AVENTIS hereby grants INDEVUS all rights of reference thereto. In
the event that (i) AVENTIS and INDEVUS have not entered into such supply
agreement relating to the manufacture and supply of the Nucleus by AVENTIS in
the time period set forth in Section 3.8 hereto, or (ii) the Parties have
entered into such supply agreement but for any reason AVENTIS or AVENTIS’
permitted assignee of such manufacturing right decides not to, or for any other
reason, does not manufacture and supply INDEVUS with the Nucleus, AVENTIS shall
promptly transfer to INDEVUS all AVENTIS Intellectual Property relating to the
manufacturing process for the Nucleus and shall provide to INDEVUS in
establishing a Third Party manufacturer of the Nucleus such reasonable
assistance as can be expected to be needed by a manufacturer having a reasonably
high level of knowledge and experience in the manufacturing of comparable
products. Such assistance will be provided free of charge to the extent that
information has to be supplied, and on the basis of cost reimbursement if any
employee of AVENTIS has to come on the concerned manufacturing premise, which in
any case should be for a limited period of time, to be specified in the
aforesaid supply agreement.

 

3.2 Diligence; Development and Commercialization.

 

3.2.1. INDEVUS Responsibility. INDEVUS shall use commercially reasonable efforts
to develop and commercialize Product. As used herein, “commercially reasonable
efforts” shall mean efforts and resources normally used by INDEVUS for a product
owned by it or to which it has exclusive rights, which is of similar market
potential at a similar stage in its development or product life, taking into
account issues of safety and efficacy, product profile, the

 

10

--------------------------------------------------------------------------------

competitiveness of the marketplace, the proprietary position of the compound or
product, the regulatory and reimbursement structure involved, the profitability
of the concerned products, and other relevant factors if any. In furtherance of
the objectives of the Development Program, INDEVUS shall provide general
management and project management services, sufficient to support its
obligations hereunder. The obligations set forth in this Section 3.2.1 are
expressly conditioned upon the absence of any serious adverse conditions or
event relating to the safety or efficacy of Compound or Product, including the
absence of any action by any regulatory authority significantly limiting the
development or commercialization of Compound or Product.

 

3.2.2. Potential AVENTIS Contribution. AVENTIS shall have the right but not the
obligation to participate in the Development Program by conducting preclinical
studies on the Compound or Product as determined by the Committee, provided,
however, that (i) any such studies are approved in advance by the Committee and
are specifically included in a Development Plan; (ii) all internal costs of any
such studies shall be borne by AVENTIS, but AVENTIS shall be entitled to
reimbursement by INDEVUS of costs incurred and paid by AVENTIS to Third Parties
in conducting such studies if such costs are approved in advance in writing by
INDEVUS, upon submission of appropriate supporting documentation therefore; and
(iii) AVENTIS shall promptly report to INDEVUS the results of any such studies
conducted by or on behalf of AVENTIS.

 

3.3 Steering Committee. The Parties hereby establish a steering committee (the
“Committee”) to facilitate the Development Program as follows:

 

3.3.1. Composition of the Committee. The Development Program shall be conducted
by INDEVUS under the supervision of the Committee, to the extent set forth
herein. The Committee shall be comprised of [*] named representatives of INDEVUS
and [*] named representatives of AVENTIS. The initial representatives for each
Party hereto are set forth on Schedule 3.3.1 hereto. Each Party may substitute
one or more of its representatives, in its sole discretion, effective upon
notice to the other Party of such change. After Regulatory Approval has been
obtained, the Parties will discuss whether the Committee should be dissolved.
Additional representatives or consultants may from time to time, by mutual
consent of the Parties, be invited to attend Committee meetings, subject to
compliance with Section 4.1. The Committee shall use its good faith efforts to
resolve by consensus any issue relating to the Development Program. If the
Committee shall arrive at a consensus on any issue relating to the Development
Program, such consensus shall be binding upon the Parties hereto. All issues
relating to costs of the Development Program shall be determined by and, except
as otherwise contemplated by this Agreement, the responsibility of, INDEVUS.

 

3.3.2. Committee Resolution. If the Committee is unable to reach a consensus on
any issue within thirty (30) days after such issue being presented to the
Committee by a Party, notwithstanding the exercise of its best efforts, then
such issue shall be referred to the chief executive officers of INDEVUS and
AVENTIS (the “CEOs”). Any final decision of the CEOs shall be conclusive and
binding on the Parties hereto, and must be reached, if practicable under the
circumstances, within thirty (30) days after being referred to the CEOs. In the
event that the Committee and/or the CEOs are unable to reach a consensus, issues
shall be determined finally and conclusively by INDEVUS.

 

*CONFIDENTIAL TREATMENT REQUESTED

 

11

--------------------------------------------------------------------------------

3.3.3. Meetings. During the Development Program, the Committee shall meet at
least once each Calendar Quarter, starting in the Calendar Quarter in which this
Agreement is executed, with the location for such meetings to be determined by
the Committee, unless no later than thirty (30) days in advance of any meeting
there is a determination by INDEVUS that no new business or other activity has
transpired since the previous meeting, and that there is no need for a meeting.
In such instance, the next quarterly meeting will be scheduled. The Committee
may meet by means of conference call or other similar communications equipment.
Each Party shall bear its own costs in connection with meetings of the
Committee.

 

3.3.4. Committee Responsibilities. Except as specifically set forth in this
Agreement, the Committee shall be responsible for overseeing the Development
Program, including (i) reviewing and approving the Development Plan prepared by
INDEVUS; (ii) facilitating the transfer of know-how as contemplated by this
Agreement; (iii) coordinating scientific interactions; (iv) managing and
assessing the progress of the development of Product and, to the extent
contemplated by this Agreement, evaluating and, if determined by the Committee,
approving AVENTIS to perform tasks required in connection with development of
Product; and (v) resolving any disputes between the Parties relating to the
Development Program. At each meeting, INDEVUS shall summarize the status of
INDEVUS’ clinical development and regulatory activities with respect to Product,
including any significant INDEVUS Know-How generated by INDEVUS in the course of
conducting the Development Program. Any disclosures of such progress, results or
know-how in any meeting shall be deemed Proprietary Information of INDEVUS.

 

3.3.5. Development Plan. Subject to the other provisions of this Section 3.3,
the Development Program shall be governed by a plan which shall be provided by
INDEVUS to the Committee (the “Development Plan), except that (i) the
Development Plan for Year 1 of the Development Program is attached hereto as
Exhibit 3.3.5, and (ii) all budget decisions relating to any Development Plan or
the Development Program shall be determined solely by INDEVUS. Periodically,
INDEVUS shall update the Development Plan, which update shall be reviewed and
approved by the Committee, as per Section 3.3.4. (i).

 

3.3.6. Primary Contacts. INDEVUS and AVENTIS each shall appoint a person (a
“Primary Contact”) to be the primary contact between the Parties with respect to
the Development Program and to coordinate correspondence between the Parties.
Each Party shall notify the other in writing within thirty (30) days after the
Effective Date of the appointment of its Primary Contact and shall notify the
other Party as soon as practicable upon changing this appointment in accordance
with Section 9.4. The Primary Contact of each Party will be one of its three
representatives in the Committee.

 

3.4 Reports. INDEVUS shall provide to the AVENTIS Primary Contact a copy of the
annual reports to the INDs submitted by INDEVUS. Any disclosures of such
clinical trial progress and results in any of the foregoing reports shall be
deemed Proprietary Information of INDEVUS.

 

3.5 Regulatory Matters.

 

3.5.1. INDEVUS shall own, control and retain primary legal responsibility for
the preparation, filing and prosecution of all filings, regulatory applications
and Regulatory

 

12

--------------------------------------------------------------------------------

Approvals. INDEVUS shall promptly notify AVENTIS upon the receipt of Regulatory
Approvals and of the date of First Commercial Sale.

 

3.5.2. AVENTIS shall transfer to INDEVUS as soon as practicable after the
Effective Date any other regulatory filings relating to Compound or Product
owned or controlled by AVENTIS, if any, and AVENTIS shall file a Drug Master
File relating to the Nucleus if it is required by INDEVUS or a Regulatory
Authority for conducting clinical studies or for obtaining Regulatory Approval
for the Product, and Aventis will allow INDEVUS to cross reference any Drug
Master File relating to the Nucleus.

 

3.6 Trademark. INDEVUS shall select, own and maintain trademarks for Product in
the Territory.

 

3.7 Inventory. AVENTIS represents and warrants that (i) its current inventory is
listed on Exhibit 3.7, provided that such inventory will be re-tested and, where
applicable re-released, (and the resulting quantities will be less than the
quantities listed in Exhibit 3.7) (the “AVENTIS Inventory”) and (ii) the
manufacture, testing, delivery and storage of the AVENTIS Inventory will upon
re-release, conform to the Specifications set forth in Schedule 1.46 and the
specifications set forth in Exhibit 3.7 and, for so long as such Inventory is
held for the account of INDEVUS as set forth in the following sentence, shall be
held in compliance with cGMPs and all other applicable laws and regulations.
Effective as of the Effective Date, all right, title and interest in the
AVENTIS’ Inventory shall be transferred to INDEVUS at AVENTIS’ expense and shall
remain at AVENTIS in the name of and for the account of INDEVUS. However,
INDEVUS shall bear all risk of partial or total deterioration or loss after
transfer of title and interest to INDEVUS, without any recourse against AVENTIS
in relation thereto.

 

3.8 Manufacturing and Supply. INDEVUS shall have all rights and responsibility
relating to chemistry, manufacturing and control for clinical and commercial use
of Compound or Product such as but not limited to process development, scale up
and manufacturing of Compound and Product, subject to the following:

 

  (a)   Manufacture of Nucleus. AVENTIS shall retain the right to manufacture
and supply or, subject to the provisions of this Section 3.8 (a), have
manufactured or have supplied the Nucleus for additional clinical trials and for
commercial use by INDEVUS, provided that (i) AVENTIS can manufacture and supply,
or any Third Party manufacturer that is a permitted assignee of AVENTIS’ rights
under this Section 3.8 (a) can manufacture and supply, the Nucleus in accordance
with cGMP and other regulatory requirements; and (ii) AVENTIS shall not have the
right to assign its rights under this Section 3.8 (a) to a Third Party
manufacturer or supplier of the Nucleus, without INDEVUS’ prior written consent,
except with a sale or other divesture of the manufacturing site where the
Nucleus is manufactured; and (iii) any such manufacture and supply is in
accordance with the terms of the agreement referred to in the next sentence.
INDEVUS and AVENTIS shall negotiate in good faith to enter into a manufacturing
and supply agreement between the Parties containing mutually acceptable terms
within [*] days after the Effective Date, which shall set forth the terms and
conditions of the manufacturing and supply of the Nucleus.

 

*CONFIDENTIAL TREATMENT REQUESTED

 

13

--------------------------------------------------------------------------------

  (b)   Other Manufacturing. In connection with any other manufacturing and
supply of Compound and/or Product, INDEVUS will consider AVENTIS in priority to
any Third Party, as such manufacturer and supplier.

 

ARTICLE IV

CONFIDENTIALITY AND PUBLICITY

 

4.1 Non-Disclosure and Non-Use Obligations. All Proprietary Information
disclosed by one Party to the other Party hereunder shall be maintained in
confidence and shall not be disclosed to any Third Party or used for any purpose
except as expressly permitted herein without the prior written consent of the
Party that disclosed the Proprietary Information to the other Party during the
term of this Agreement and for a period of five years thereafter. The foregoing
non-disclosure and non-use obligations shall not apply to the extent that such
Proprietary Information:

 

  (a)   is known by the receiving Party at the time of its receipt, and not
through a prior disclosure by the disclosing Party, as documented by business
records;

 

  (b)   is or becomes properly in the public domain or knowledge;

 

  (c)   is subsequently disclosed to a receiving Party by a Third Party who may
lawfully do so and is not under an obligation of confidentiality to the
disclosing Party; or

 

  (d)   is developed by the receiving Party independently of Proprietary
Information received from the other Party, as documented by research and
development records.

 

4.2 Permitted Disclosure of Proprietary Information. Notwithstanding Section
4.1, a Party receiving Proprietary Information of another Party may disclose
such Proprietary Information:

 

  (a)   to governmental or other agencies in order to obtain patents pursuant to
this Agreement, or to gain approval to conduct clinical trials or to market
Product, but such disclosure may be only to the extent reasonably necessary to
obtain such patents or approvals;

 

  (b)   by each of INDEVUS or AVENTIS to its respective agents, consultants,
Affiliates, INDEVUS’ sublicensees and/or other Third Parties for the research
and development, manufacturing and/or marketing of the Compound and/or Product
(or for such parties to determine their interests in performing such activities)
on the condition that such Third Parties agree to be bound by confidentiality
obligations consistent with this Agreement; provided, however, that except if
such disclosure is required by law or is in connection with obtaining any
Regulatory Approval, INDEVUS shall inform AVENTIS prior to disclosing to a Third
Party

 

14

--------------------------------------------------------------------------------

AVENTIS Proprietary Information relating to the production of Compound and shall
give due consideration to AVENTIS’ reasonable comments or objections to such
disclosure; or

 

  (c)   if required to be disclosed by law or court order, provided that notice
is promptly delivered to the non-disclosing Party in order to provide an
opportunity to challenge or limit the disclosure obligations; provided, however,
without limiting any of the foregoing, it is understood that the Parties or
their Affiliates may make disclosure of this Agreement and the terms hereof in
any filings required by the Securities and Exchange Commission (“SEC”), may file
this Agreement as an exhibit to any filing with the SEC and may distribute any
such filing in the ordinary course of its business, provided, however, that to
the maximum extent allowable by SEC rules and regulations, the Parties shall be
obligated to maintain the confidentiality obligations set forth herein and shall
redact any confidential information set forth in such filings.

 

  (d)   Upon execution of this Agreement, either Party may issue a press
release, provided that any such Party shall provide the other Party with a draft
of such press release for review at least one Business Day prior to its intended
release. .

 

4.3 Publication. AVENTIS shall not submit for written or oral publication any
manuscript, abstract or the like relating to Compound or Product, without the
prior approval of INDEVUS. If AVENTIS proposes to submit such publication, it
shall deliver the proposed publication at least thirty (30), or an outline of
the oral disclosure at least fifteen (15), Business Days prior to planned
submission or presentation. At the request of INDEVUS, the submission of such
publication may be delayed, including for issues of patent protection or other
matters relating to the development of Compound or Product to be addressed in
accordance with the terms of this Agreement. This section shall apply on a
reciprocal basis in the case when INDEVUS proposes to submit an oral or written
publication that may have an impact on the patentability of AVENTIS Intellectual
Property.

 

4.4 Collaboration Information and Inventions.

 

  (a)   Subject to the provisions of Section 4.4(b), the entire right, title and
interest in all discoveries, Improvements, processes, formulas, information,
data, inventions, know-how and trade secrets, patentable or otherwise, that are
primarily used or useful for the development, manufacturing and/or Regulatory
Approval of Compound or Product and are obtained, generated, derived, developed
or invented in the course of carrying out the Development Program (collectively,
“Program Information and Inventions”):

 

(i) solely by employees of AVENTIS shall be owned by AVENTIS (“AVENTIS
Information and Inventions”);

 

(ii) solely by employees of INDEVUS shall be owned solely by INDEVUS (“INDEVUS
Information and Inventions”); and

 

15

--------------------------------------------------------------------------------

(iii) jointly by employees of AVENTIS and employees of INDEVUS shall be owned
jointly by AVENTIS and INDEVUS (“Joint Information and Inventions”).

 

Each Party shall promptly disclose to the other Party hereto the development,
making, conception or reduction to practice of Program Information and
Inventions as soon as practical after such information is obtained. Section 4.1
shall apply to such disclosure.

 

  (b)   INDEVUS shall retain all right, title and interest in and to any INDEVUS
Information and Inventions and to its interest in all Joint Information and
Inventions. AVENTIS shall retain all right, title and interest in and to any
AVENTIS Information and Inventions and to its interest in all Joint Information
and Inventions, all of which shall be included in the license granted to INDEVUS
under this Agreement

 

ARTICLE V

PAYMENTS; ROYALTIES AND REPORTS

 

5.1 License Fee. In consideration of the rights granted by AVENTIS hereunder,
INDEVUS shall pay AVENTIS US $[*] within five (5) Business Days after the
Effective Date.

 

5.2 Milestone Payments. Subject to the terms and conditions contained in this
Agreement, and in further consideration of the rights granted by AVENTIS
hereunder, INDEVUS shall pay AVENTIS the following milestone payments,
contingent upon occurrence of the specified event, with each milestone payment
to be made no more than once with respect to the achievement of such milestone
and no amounts payable for any subsequent or repeated achievement of such
milestones, regardless of the number of Products for which such milestone may be
achieved (but payable the first time such milestone is achieved) for Product:

 

5.2.1. For the first IV formulation of the first Product:

 

  (a)   US $[*] upon commencement (first dosing of the first patient) of first
multiple dose Phase 1 Clinical Trial;

 

  (b)   US $[*] upon commencement (first dosing of the first patient) of first
Phase 2 Clinical Trial;

 

  (c)   US $[*] upon the commencement (first dosing of the first patient) of the
first Phase 3 Clinical Trial;

 

  (d)   US $[*] upon the FDA’s acceptance for filing of the first NDA;

 

  (e)   US $[*] upon the first acceptance for filing of an NDA with the EMEA;

 

  (f)   US $[*] upon the first acceptance for filing of an NDA in Japan;

 

*CONFIDENTIAL TREATMENT REQUESTED

 

16

--------------------------------------------------------------------------------

  (g)   US $[*] upon receipt of first written Regulatory Approval in the United
States by the FDA;

 

  (h)   US $[*] upon receipt of written Regulatory Approval by the EMEA;

 

  (i)   US $[*] upon receipt of written Regulatory Approval by the Regulatory
Authority in Japan;

 

  (j)   US $[*] upon the achievement of cumulative Net Sales of US $[*];

 

  (k)   US $[*] upon the achievement of cumulative Net Sales of US $[*];

 

  (l)   US $[*] upon the achievement of cumulative Net Sales of US $[*]; and

 

  (m)   US $[*] upon the achievement of cumulative Net Sales of US $[*].

 

  5.2.2.   For the first oral formulation of the first Product:

 

  (a)   US $[*] upon the commencement (first dosing of the first patient) of the
first Phase 3 Clinical Trial;

 

  (b)   US $[*] upon the FDA’s acceptance for filing of the first NDA;

 

  (c)   US $[*] upon the first acceptance for filing of an NDA by the EMEA;

 

  (d)   US $[*] upon the first acceptance for filing of an NDA in Japan;

 

  (e)   US $[*] upon receipt of first written Regulatory Approval in the United
States by the FDA;

 

  (f)   US $[*] upon receipt of written Regulatory Approval by the EMEA;

 

  (g)   US $[*] upon receipt of written Regulatory Approval by the Regulatory
Authority in Japan;

 

  (h)   US $[*] upon the achievement of cumulative Net Sales of US $[*];

 

*CONFIDENTIAL TREATMENT REQUESTED

 

17

--------------------------------------------------------------------------------

  (i)   US $[*] upon the achievement of cumulative Net Sales of US $[*];

 

  (j)   US $[*] upon the achievement of cumulative Net Sales of US $[*];

 

  (k)   US $[*] upon the achievement of cumulative Net Sales of US $[*]; and

 

  (l)   US $[*] upon the achievement of cumulative Net Sales of US $[*].

 

INDEVUS shall notify AVENTIS in writing within fifteen (15) Business Days after
the achievement of each milestone (ninety (90) days for milestones 5.2.1 (j)
through (m) and 5.2.2 (h) through (l)), and such notice shall be accompanied by
the appropriate milestone payment.

 

5.3 Royalties and Other Payments.

 

5.3.1. Royalties Payable By INDEVUS.

 

(i) Subject to the terms and conditions of this Agreement, and in further
consideration of the rights granted by AVENTIS hereunder, INDEVUS shall pay to
AVENTIS royalties in the applicable percentage set forth below for Net Sales of
Prescription Products in each Royalty Year in the United States by INDEVUS or
its Affiliates, as applicable, if the manufacture, use or sale of such
Prescription Products would, absent the license granted hereunder, infringe one
or more Valid Claims of the AVENTIS Patent Assets in the United States:

 

Annual Net Sales in U.S.:

--------------------------------------------------------------------------------

  

Royalty Rate:

--------------------------------------------------------------------------------

Up to US$[*]

   [*]%

From US$[*] up

   [*]%

 

(ii) Subject to the terms and conditions of this Agreement, and in further
consideration of the rights granted by AVENTIS hereunder, INDEVUS shall pay to
AVENTIS royalties equal to the applicable percentage set forth below for total
Net Sales of Prescription Products in each country in the Territory other than
the United States in each Royalty Year by INDEVUS or its Affiliates where the
manufacture, use or sale of such Prescription Product would, absent the license
granted hereunder, infringe one or more Valid Claims of the AVENTIS Patent
Assets in such country:

 

Total Annual Net Sales outside U.S.:

--------------------------------------------------------------------------------

  

Royalty Rate:

--------------------------------------------------------------------------------

Up to US$[*]

   [*]%

From US$[*] up

   [*]%

 

(iii) Royalties on Net Sales at the rates set forth in (i) and (ii) above shall
accrue as of the date of First Commercial Sale of Product in the applicable
country and shall continue and accrue on Net Sales on a country-by-country basis
until the expiration of all AVENTIS Patent Assets in such country, provided,
however, that no royalties shall be payable in

 

*CONFIDENTIAL TREATMENT REQUESTED

 

18

--------------------------------------------------------------------------------

respect of Net Sales of Product in any country during any period in which lawful
Generic Competition exists in such country. Thereafter, INDEVUS shall be
relieved of any royalty payment under this Section 5.3.

 

  (iv)   The payment of royalties set forth above shall be subject to the
following conditions:

 

(a) only one payment shall be due with respect to the same unit of Product; and

 

(b) no royalties shall accrue on the disposition of Product by INDEVUS,
Affiliates or sublicensees as samples (promotion or otherwise) or as reasonable
donations (for example, to non-profit institutions or government agencies) or to
clinical trials.

 

  (v)   In the event that INDEVUS or any INDEVUS Affiliate or sublicensee
determines to commercialize Product as an Over-the-Counter Product, the Parties
shall negotiate in good faith a royalty payable to AVENTIS on Net Sales of
Over-the-Counter Products in countries where the manufacture, use or sale of
such Over-the-Counter Product would, absent the license granted hereunder,
infringe one or more Valid Claims of the AVENTIS Patent Assets in such country.

 

  (vi)   In those countries in the Territory in which no Valid Claim of the
AVENTIS Patent Assets exists as of the date of First Commercial Sale of Product
INDEVUS would pay to AVENTIS, in consideration of the license under AVENTIS Know
How, royalties on Net Sales of Products in such country(ies) at rates that are
[*] of the rates stated in Section 5.3.1(i) or (ii), as applicable (or with
respect to Over-the-Counter Products, the rates determined in accordance with
Section 5.3.1 (v)), for a period expiring on the expiration date of the last to
expire United States patent included in the AVENTIS Patent Assets, as long as
the AVENTIS Know-How is not in the public domain and provided there is no
Generic Competition in such country. Notwithstanding the foregoing, no royalties
shall be payable in respect of Net Sales of any Product in any country of the
Territory as of and after the date on which Generic Competition exists in the
applicable country.

 

5.3.2. Payments in the Event of Sublicense. In the event INDEVUS enters into one
or more sublicense agreement(s) with one or more Third Party or Third Parties
under Section 2.3 of this Agreement, the respective percentages of royalties set
forth in Section 5.3.1 would no longer be applicable to the Net Sales in the
country or countries covered by the sublicense agreement(s) and, in lieu
thereof, AVENTIS would receive the following respective percentages of the total
Sublicense Royalty Payments for the concerned country(ies):

 

  •   [*] percent ([*]%) if the sublicense agreement is entered into [*];

 

  •   [*] percent ([*]%) if the sublicense agreement is entered into [*]; and

 

*CONFIDENTIAL TREATMENT REQUESTED

 

19

--------------------------------------------------------------------------------

  •   [*] percent ([*]%) if the sublicense agreement is entered into [*].

 

In order to calculate the amounts due to AVENTIS under this Section 5.3.2, it is
understood that (i) any payment to INDEVUS by a sublicensee that is triggered by
Net Sales (such as but not limited to fees) shall be considered Sublicense
Royalty Payments; and (ii) if no royalties or a lower royalty percentage is paid
by INDEVUS’ Sublicensee in consideration of an increased margin received by
INDEVUS on Compound or Product supply or of higher milestones payments, such
excess payments shall be considered Sublicense Royalty Payments.

 

5.3.3. Affiliate and Sublicensee Sales. In the event that INDEVUS transfers
Compound (for conversion to Product) or Product to one of its Affiliates or
Sublicensees, there shall be no royalty due at the time of transfer. Subsequent
sales of Product by the Affiliate or the Sublicensee to end users such as
patients, hospitals, medical institutions, health plans or funds, wholesalers,
pharmacies or other retailers, shall be reported as Net Sales hereunder by
INDEVUS.

 

5.3.4. Compulsory Licenses. If a compulsory license is granted to a Third Party
with respect to Product in any country in the Territory with a royalty rate
lower than the royalty rate provided by Section 5.3.1, then the royalty rate to
be paid by INDEVUS on Net Sales in that country under Section 5.3.1 shall be
reduced to the rate paid by the compulsory Third Party licensee, provided
Indevus can show appropriate evidence that Indevus has used commercially
reasonable efforts (i) to avoid having to grant such Compulsory License and (ii)
to obtain the highest possible royalty rate from such Compulsory Licensee.

 

5.3.5. Third Party Licenses. If INDEVUS would be prevented from developing,
making, having made, using, selling or importing Product in any country of the
Territory on the grounds that by doing so INDEVUS or any sublicensee would
infringe a Dominating Patent or other patent rights held by a Third Party in
said country, [*] percent ([*]%) of any royalties or other payments payable or
paid by INDEVUS to such Third Party in such country in any Royalty Year shall be
creditable against the royalty or other payments payable to AVENTIS by INDEVUS
in such country for such Royalty Year, provided that in such event AVENTIS has
been informed of the Dominating Patent and has had an opportunity to provide
input on any related discussion.

 

5.3.6. Combination Product. Notwithstanding the provisions of Section 5.3.1, in
the event a Product is sold as a combination product with other biologically
active components, Net Sales, for purposes of royalty payments on the
combination product, shall be calculated by multiplying the Net Sales of that
combination product by the fraction A/B, where A is the gross selling price of
the Product sold separately and B is the gross selling price of the combination
product. If no such separate sales are made by INDEVUS or its Affiliates, Net
Sales for royalty determination shall be calculated by multiplying Net Sales of
the combination product by the fraction C/(C+D), where C (excluding the fully
allocated cost of the other biologically active component in question) is the
fully allocated cost of the Compound and D is the fully allocated cost of such
other biologically active components.

 

5.4 Reports; Payment of Royalty. During the term of the Agreement for so long as
royalty or other payments are due, INDEVUS shall furnish to AVENTIS a quarterly
written report for the

 

*CONFIDENTIAL TREATMENT REQUESTED

 

20

--------------------------------------------------------------------------------

Calendar Quarter showing (i) the Net Sales of all Products sold by INDEVUS or
its Affiliates or sublicensees, as applicable, during the reporting period, (ii)
the royalties or other payments payable to AVENTIS under this Agreement, (iii)
in the case of sales outside the United States the calculation of the conversion
to United States dollars as per Section 5.6, and (iv) in the case of a
sublicense, Sublicense Royalty Payments received by INDEVUS. Reports shall be
due on the [*] day following the close of each Calendar Quarter. Royalties or
other payments shown to have accrued by each royalty report, if any, shall be
due and payable on the date such report is due. INDEVUS shall keep complete and
accurate records in sufficient detail to enable the royalties or other payments
hereunder to be determined.

 

5.5 Audits. Upon the written request of AVENTIS and not more than once in each
Calendar Year, INDEVUS shall permit an independent certified public accounting
firm selected by AVENTIS and consented to in writing by INDEVUS, which consent
shall not be unreasonably withheld, to have access during normal business hours,
upon ten-days notice to INDEVUS, to such of the records of INDEVUS as may be
necessary to verify the accuracy of the royalty reports hereunder for any
Royalty Year ending not more than [*] months prior to the date of such request.
The accounting firm shall disclose to AVENTIS only whether the royalty reports
are correct or incorrect and the specific details concerning any discrepancies.

 

5.5.1. If such accounting firm concludes that additional royalties were owed
during such Royalty Year, INDEVUS shall pay the additional royalties within [*]
days of the date AVENTIS delivers to INDEVUS such accounting firm’s written
report so concluding. In the event such accounting firm concludes that amounts
were overpaid by INDEVUS during such period, AVENTIS shall repay INDEVUS the
amount of such overpayment within [*] days of the date AVENTIS delivers to
INDEVUS such accounting firm’s written report so concluding. The fees charged by
such accounting firm shall be paid by AVENTIS; provided, however, that if an
error in favor of AVENTIS of more than the greater of (i) $[*] or (ii) [*]
percent ([*]%) of the royalties due hereunder for the period being reviewed is
discovered, then the fees and expenses of the accounting firm shall be paid by
INDEVUS.

 

5.5.2. Upon the expiration of [*] months following the end of any Royalty Year
the calculation of royalties payable with respect to such year shall be binding
and conclusive upon AVENTIS, and INDEVUS shall be released from any liability or
accountability with respect to royalties for such year.

 

5.5.3. AVENTIS shall treat all financial information subject to review under
this Section 5.5 in accordance with the confidentiality provisions of this
Agreement and shall cause its accounting firm to enter into a reasonable and
mutually satisfactory confidentiality agreement with INDEVUS obligating it to
retain all such financial information in confidence pursuant to such
confidentiality agreement.

 

5.6 Payment Exchange Rate. All payments to AVENTIS under this Agreement shall be
made in United States dollars. In the case of sales invoiced in a currency other
than the US dollar, the rate of exchange to be used in computing Net Sales shall
be calculated monthly in accordance with GAAP and based on the conversion rates
published in the Wall Street Journal, Eastern edition (if available).

 

*CONFIDENTIAL TREATMENT REQUESTED

 

21

--------------------------------------------------------------------------------

5.7 Late Payment. In case of late payment of any payment due hereunder by
INDEVUS (milestones or royalties) or in case of additional payment due by
INDEVUS pursuant to Section 5.5.1, INDEVUS shall pay to AVENTIS interest on the
unpaid amount until such payment is paid in full, at the LIBOR Rate (as defined
below), plus [*], but in no event in excess of the maximum rate permitted by
applicable law. “LIBOR Rate” means an interest rate per annum equal to the rate
of interest per annum at which deposits in United States dollars are offered by
the principal office of Citibank, N.A. in London, England, to prime banks in the
London interbank market at 11:00 a.m. (London time) on the Business Day
immediately preceding the commencement of such interest period.

 

5.8 Tax Withholding. If laws, rules or regulations require withholding of income
taxes or other taxes imposed upon payments set forth in this Article V, AVENTIS
shall provide INDEVUS, prior to any such payment, once each Royalty Year or more
frequently if required, with all forms or documentation required by any
applicable taxation laws, treaties or agreements to such withholding or as
necessary to claim a benefit thereunder (including, but not limited to United
States Internal Revenue Service Form W-8BEN or any successor forms) and INDEVUS
shall make such withholding payments as required and subtract such withholding
payments from the payments set forth in this Article V. INDEVUS will use
commercially reasonable efforts consistent with its usual business practices and
cooperate with AVENTIS to reduce any withholding taxes imposed as far as
possible under the provisions of the current or any future taxation treaties or
agreements between foreign countries. INDEVUS will cooperate and assist AVENTIS
in having adequate documentation to claim tax credits for any and all taxes
withheld pursuant to this Article V. To that end, within thirty (30) days of
remitting any and all taxes withheld to the tax authorities, INDEVUS shall
provide to AVENTIS proof of its remittance of taxes withheld from payments made
to AVENTIS, and on an annual basis will provide AVENTIS with a United States
Internal Revenue Service Form 1042-S and comparable state or local forms, if
any, or successor federal forms

 

5.9 Exchange Controls. Notwithstanding any other provision of this Agreement, if
at any time legal restrictions prevent the prompt remittance of part or all of
the royalties with respect to Net Sales in any country, payment shall be made
through such lawful means or methods as INDEVUS may determine in consultation
with AVENTIS. When in any country the law or regulations prohibit both the
transmittal and deposit of royalties on sales in such a country, royalty
payments shall be suspended for as long as such prohibition is in effect (and
such suspended payments shall not accrue interest), and promptly after such
prohibition ceases to be in effect, all royalties or other payments that INDEVUS
or its Affiliates would have been obligated to transmit or deposit, but for the
prohibition, shall be deposited or transmitted, as the case may be, to the
extent allowable (with any interest earned on such suspended royalties which
were placed in an interest-bearing bank account in that country, less any
transactional costs). If the royalty rate specified in this Agreement should
exceed the permissible rate established in any country, the royalty rate for
sales in such country shall be adjusted to the highest legally permissible or
government-approved rate.

 

*CONFIDENTIAL TREATMENT REQUESTED

 

22

--------------------------------------------------------------------------------

ARTICLE VI

REPRESENTATIONS AND WARRANTIES

 

6.1 AVENTIS Representations and Warranties. AVENTIS represents and warrants to
INDEVUS that as of the Effective Date:

 

  (a)   the pending patent applications and the issued patents included in the
AVENTIS Patent Assets are in existence and, to the best of AVENTIS’ knowledge,
recite patentable subject matter and contain claims that are valid and
enforceable, respectively; and AVENTIS will comply and abide by the rules and /
or statutes governing the prosecution, issuance and maintenance of such pending
patent applications and issued patents in each applicable country of the
Territory;

 

  (b)   this Agreement has been duly executed and delivered by AVENTIS and
constitutes legal, valid, and binding obligations enforceable against AVENTIS in
accordance with its terms, except as enforceability is limited by any applicable
bankruptcy, insolvency, reorganization, moratorium or similar law affecting
creditor’s rights generally;

 

  (c)   no approval, authorization, consent, or other order or action of or
filing with any court, administrative agency or other governmental authority is
required for the execution and delivery by AVENTIS of this Agreement or the
consummation by AVENTIS of the transactions contemplated hereby;

 

  (d)   AVENTIS has the full corporate power and authority to enter into and
deliver this Agreement, to perform and to grant the licenses granted under
Article II hereof and to consummate the transactions contemplated hereby; all
corporate acts and other proceedings required to be taken to authorize such
execution, delivery, and consummation have been duly and properly taken and
obtained;

 

  (e)   AVENTIS has not previously assigned, transferred, conveyed or otherwise
encumbered its right, title and interest in the AVENTIS Intellectual Property,
including the Nucleus, or entered into any agreement with any Third Party which
is in conflict with the rights granted to INDEVUS pursuant to this Agreement;

 

  (f)   it is the sole owner of the AVENTIS Intellectual Property including the
Nucleus, all of which are free and clear of any liens, charges and encumbrances,
no other person, corporate or other private entity, or governmental or
university entity or subdivision thereof has any claim of ownership or rights
with respect to the AVENTIS Intellectual Property, including the Nucleus,
whatsoever;

 

  (g)   AVENTIS has disclosed to INDEVUS the complete texts of all patents or
patent applications relating to Compound or Product that are in existence

 

23

--------------------------------------------------------------------------------

on the Effective Date and that are the property of AVENTIS as well as all
information received by AVENTIS concerning the institution or possible
institution of any interference, opposition, re-examination, reissue,
revocation, nullification, or any official proceeding involving an AVENTIS
Patent Asset, and that it will continue such disclosure with respect to new
events during the term of the Agreement;

 

  (h)   Schedule 1.5 is a complete and accurate list of all patents and patent
applications in the Territory relating to Compound or Product owned or
exclusively licensed by AVENTIS and to which AVENTIS has the right to license;

 

  (i)   As of the Effective Date, to the best of AVENTIS’ knowledge, the
contemplated development, importation, manufacture, use, offer for sale and sale
of Compound included in the AVENTIS Patent Assets or Product or Nucleus would
not infringe any patent rights owned or possessed by any Third Party;

 

  (j)   there are no claims, judgments or settlements against or owed by AVENTIS
relating to the AVENTIS Patent Assets or pending or, to the best of AVENTIS’
knowledge, threatened claims or litigation against AVENTIS relating to the
AVENTIS Patent Assets;

 

  (k)   AVENTIS has disclosed to INDEVUS all relevant information known by it
regarding the AVENTIS Intellectual Property and it has no knowledge of the
existence of any preclinical or clinical data or information relating to
Compound or Product that has not been disclosed to INDEVUS that could materially
influence INDEVUS’ decision to enter into this Agreement;

 

  (l)   no contract research organization, corporation, business entity or
individual which have been involved in any studies conducted for the purpose of
obtaining regulatory approvals have been debarred individuals or entities within
the meaning of 21 U.S.C. section 335(a) or (b); and

 

  (m)   in connection with development of Nucleus, Compound and Product, AVENTIS
has complied and is complying in all material respects with applicable U.S. and
European laws and regulations including U.S. good laboratory practices in its
conduct of toxicology studies on Compound and U.S. good clinical practices in
its conduct of clinical studies on Compound.

 

  (n)   as of the Effective Date, there are no contracts, agreements and other
arrangements between AVENTIS and any Third Parties relating to the research,
development or commercialization of the Nucleus, Compound or Product that could
impair the exercise of the rights granted to INDEVUS hereunder.

 

24

--------------------------------------------------------------------------------

6.2 INDEVUS Representations and Warranties. INDEVUS represents and warrants to
AVENTIS that as of the Effective Date:

 

  (a)   this Agreement has been duly executed and delivered by it and
constitutes legal, valid, and binding obligations enforceable against it in
accordance with its terms except as enforceability is limited by any applicable
bankruptcy, insolvency, reorganization, moratorium or similar law affecting
creditor’s rights generally;

 

  (b)   it has full corporate power and authority to execute and deliver this
Agreement and to consummate the transactions contemplated hereby. All corporate
acts and other proceedings required to be taken to authorize such execution,
delivery, and consummation have been duly and properly taken and obtained; and

 

  (c)   no approval, authorization, consent, or other order or action of or
filing with any court, administrative agency or other governmental authority is
required for the execution and delivery by it of this Agreement or the
consummation by it of the transactions contemplated hereby.

 

ARTICLE VII

PATENT MATTERS

 

7.1 Filing, Prosecution and Maintenance of AVENTIS Patent Assets. AVENTIS shall
have the first right to file, prosecute and maintain the AVENTIS Patent Assets
and patents on AVENTIS Information and Inventions in AVENTIS’ name and shall be
responsible for the payment of all patent prosecution and maintenance costs. If
AVENTIS elects not to file, prosecute or maintain a patent application or patent
included in the AVENTIS Patent Assets in any particular country, it shall
provide INDEVUS with written advance notice sufficient to avoid any loss or
forfeiture, and INDEVUS shall have the right, but not the obligation, at its
expense, to file, prosecute or maintain such patent application or patent in
such country in AVENTIS’ name. Thereafter, INDEVUS’ royalty obligations related
to that AVENTIS Patent Asset in such country shall terminate and such patent or
patent application in such country shall no longer be deemed an AVENTIS Patent
Asset. Upon the reasonable request of one Party, the other Party shall
reasonably cooperate in the filing, prosecution or maintenance of any patent
application or patent included in the AVENTIS Patent Assets. The responsible
Party under this Section 7.1 shall solicit the other Party’s review of the
nature and text of such patent applications and important prosecution matters
related thereto in reasonably sufficient time prior to filing thereof, and the
responsible Party shall take into account the other Party’s reasonable comments
related thereto. AVENTIS shall inform INDEVUS of any significant developments in
the prosecution of pending patent applications included in the AVENTIS Patent
Assets, including the issuance of any final office actions, allowance of claims,
or upcoming grant of any domestic or foreign patent based thereon.

 

7.2 Program Information and Inventions. INDEVUS shall have the first right to
file, prosecute and maintain any patent application(s) or patent(s) arising from
INDEVUS

 

25

--------------------------------------------------------------------------------

Information and Inventions and from Joint Information and Inventions and shall
be responsible for the payment of all patent prosecution and maintenance costs.
Upon INDEVUS’ request, AVENTIS shall reasonably cooperate in the filing,
prosecution or maintenance of any such patent application or patent. If INDEVUS
elects not to file, prosecute or maintain any such patent application or patent
in any particular country in the Territory, it shall provide AVENTIS with
written advance notice sufficient to avoid any loss or forfeiture, and AVENTIS
shall have the right, but not the obligation, at its sole expense, to file,
prosecute or maintain such patent application or patent in such country in
AVENTIS’ name, and INDEVUS shall transfer all right, title and interest in such
patent application or patent, and the underlying INDEVUS Information and
Inventions claimed by such patent application or patent, in such country to
AVENTIS. The responsible Party under this Section 7.2 shall solicit the other
Party’s review of the nature and text of such patent applications and important
prosecution matters related thereto in reasonably sufficient time prior to
filing thereof, and the responsible Party shall take into account the other
Party’s reasonable comments related thereto.

 

7.3 Patent Office and Court Proceedings. Each Party shall inform the other Party
of any request for, filing, or declaration of any proceeding before a patent
office seeking to protest, oppose, cancel, reexamine, declare an interference
proceeding, initiate a conflicts proceeding, or analogous process involving a
patent application or patent included in the AVENTIS Patent Assets, or of the
filing of an action in a court of competent jurisdiction seeking a judgment that
a patent included in the AVENTIS Patent Assets is either invalid or
unenforceable or both. Each Party thereafter shall cooperate fully with the
other with respect to any such patent office or court proceeding. Each Party
will provide the other with any information or assistance that is reasonable.

 

7.4 Enforcement and Defense.

 

  (a)   Each Party shall promptly give the other Party notice of any
infringement in the Territory of any patent application or patent included in
the AVENTIS Patent Assets that comes to such Party’s attention. The Parties will
thereafter consult and cooperate fully to determine a course of action,
including, without limitation, the commencement of legal action by any Party.
However, AVENTIS shall have the first right to initiate and prosecute such legal
action at its own expense and in the name of AVENTIS and INDEVUS, or to control
the defense of any declaratory judgment action relating to the AVENTIS Patent
Assets. AVENTIS shall promptly inform INDEVUS if AVENTIS elects not to exercise
such first right, and INDEVUS thereafter shall have the right either to initiate
and prosecute such action or to control the defense of such declaratory judgment
action in the name of INDEVUS and, if necessary, AVENTIS.

 

  (b)   If AVENTIS elects not to initiate and prosecute an infringement or
defend a declaratory judgment action in any country in the Territory as provided
in Subsection 7. 4(a), and INDEVUS elects to do so, the cost of any agreed-upon
course of action, including the costs of any legal action commenced or any
declaratory judgment action defended, shall be borne solely by INDEVUS.

 

26

--------------------------------------------------------------------------------

  (c)   For any such legal action or defense, in the event that any Party is
unable to initiate, prosecute, or defend such action solely in its own name, the
other Party will join such action voluntarily and will execute all documents
necessary for the Party to prosecute, defend and maintain such action. In
connection with any such action, the Parties will cooperate fully and will
provide each other with any information or assistance that either reasonably may
request.

 

  (d)   Any recovery obtained by INDEVUS or AVENTIS shall be shared as follows:

 

(i) the Party that initiated and prosecuted, or maintained the defense of, the
action shall recoup all of its costs and expenses (including reasonable
attorneys’ fees) incurred in connection with the action, whether the recovery is
by settlement or otherwise;

 

(ii) the other Party then shall, to the extent possible, recover its costs and
expenses (including reasonable attorneys’ fees) incurred in connection with the
action;

 

(iii) if AVENTIS initiated and prosecuted, or maintained the defense of, the
action, the amount of any recovery remaining then shall be retained by AVENTIS;
and

 

(iv) if INDEVUS initiated and prosecuted, or maintained the defense of, the
action, the amount of any recovery remaining shall be retained by INDEVUS,
except that AVENTIS shall receive a portion equivalent to the royalties it would
have received in accordance with the terms of this Agreement if such amount were
deemed Net Sales.

 

  (e)   the foregoing subsections (a), (b), (c) and (d) shall apply on
reciprocal basis regarding the INDEVUS Patent Assets and joint patents.

 

7.5 AVENTIS shall inform INDEVUS of any certification regarding any AVENTIS
Patent Assets it has received pursuant to either 21 U.S.C. §§ 355(b)(2)(A)(iv)
or (j)(2)(A)(vii)(IV) or under Canada’s Patented Medicines (Notice of
Compliance) Regulations Article 5 and shall provide INDEVUS with a copy of such
certification within five (5) Business Days of receipt. AVENTIS’ and INDEVUS’
rights with respect to the initiation and prosecution, or defense, of any legal
action as a result of such certification or any recovery obtained as a result of
such legal action shall be allocated as defined in Subsections 7.4(d) (i)
through (iv); provided, however, that INDEVUS shall exercise the first right to
initiate and prosecute, or defend, any action and shall inform AVENTIS of such
decision within fifteen (15) days of receipt of the certification, after which
time, if INDEVUS has not advised AVENTIS of its intention to initiate and
prosecute, or defend, such action, AVENTIS shall have the right to initiate and
prosecute, or defend, such action.

 

27

--------------------------------------------------------------------------------

7.6 Patent Term Extensions or Restorations and Supplemental Protection
Certificates. The Parties shall cooperate with each other in obtaining patent
term extensions or restorations or supplemental protection certificates or their
equivalents in any country in the Territory where applicable. If elections with
respect to obtaining such extension or supplemental protection certificates are
to be made, INDEVUS shall have the right to make the election and AVENTIS shall
abide by such election. AVENTIS shall notify INDEVUS of (a) the issuance of each
U.S. patent included within the AVENTIS Patent Assets, giving the date of issue
and patent number for each such patent, and (b) each notice pertaining to any
patent included within the AVENTIS Patent Assets pursuant to the United States
Drug Price Competition and Patent Term Restoration Act of 1984 (hereinafter
called the “1984 Act”), including notices pursuant to §§ 101 and 103 of the 1984
Act from persons who have filed an abbreviated NDA (“ANDA”). Such notices shall
be given promptly, but in any event within five (5) Business Days of each such
patent’s date of issue or receipt of each such notice pursuant to the Act,
whichever is applicable. AVENTIS shall notify INDEVUS of each filing for patent
term extension or restoration under the 1984 Act, any allegations of failure to
show due diligence and all awards of patent term restoration (extensions) with
respect to the AVENTIS Patent Assets. Likewise, AVENTIS shall inform INDEVUS of
patent extensions in the rest of the world regarding Compound or Product.

 

ARTICLE VIII

TERM AND TERMINATION

 

8.1 Term and Expiration. Subject to Section 5.3.1 (vi), this Agreement shall be
effective as of the Effective Date and unless terminated earlier pursuant to
Section 8.2 or 8.3 below, the term of this Agreement shall continue in effect on
a country-by-country basis until the date of expiration of the last to expire
patent included in the AVENTIS Patent Assets in such country. Expiration of this
Agreement under this provision shall not preclude INDEVUS from continuing to
develop, make, have made, use, sell, offer for sale, and import Product in the
Territory without further remuneration to AVENTIS.

 

8.2 Termination by Notice. Notwithstanding anything contained herein to the
contrary, INDEVUS shall have the right to terminate this Agreement at any time
after completion of a [*]:

 

  (a)   by giving [*] days advance written notice to AVENTIS, if INDEVUS
believes that the results of such trial (such as toxicology studies) lead to the
conclusion that there is no reasonable likelihood to obtain Regulatory Approval,
provided that such conclusion shall be submitted to the Committee and the
decision to terminate the Development Program and consequently the Agreement,
shall be made by the Committee; or

 

  (b)   by giving [*] days advance notice to AVENTIS, provided that: (i) INDEVUS
will, if requested by AVENTIS, cooperate with AVENTIS or AVENTIS’ designee
during such [*] day period to transfer to AVENTIS or AVENTIS’ designee the
supervision of any ongoing clinical trial in such a way that no delay incurs in
such clinical trial, if the termination of such trial would materially adversely
affect the development of Product and AVENTIS has advised INDEVUS that it
intends to continue development of Product; (ii) INDEVUS will promptly upon
having sent such notice transfer to AVENTIS or AVENTIS’ designee all data,
files,

 

*CONFIDENTIAL TREATMENT REQUESTED

 

28

--------------------------------------------------------------------------------

Regulatory Approvals, if any, and information, data, know-how, etc in the
possession of INDEVUS and related to Compound or Product; (iii) AVENTIS will be
entitled to start negotiations with Third Parties in relation to Compound or
Product immediately upon receipt of such notice; and (iv) INDEVUS will provide
AVENTIS with reasonable assistance that AVENTIS may request in responding to due
diligence requests by Third Parties that AVENTIS is negotiating with as
potential licensees for Compound or Product, provided that INDEVUS shall not be
required to disclose to such Third Parties INDEVUS Proprietary Information that
does not relate to Compound or Product.

 

Except as otherwise set forth in this Agreement, in the event of such
termination, (i) the rights and obligations hereunder, excluding any payment
obligation that has accrued as of the termination date and excluding rights and
obligations relating to confidentiality, shall terminate immediately, and (ii)
the provisions of Section 8.4 shall be applicable.

 

8.3 Termination.

 

8.3.1. Termination for Cause. Either Party may terminate this Agreement by
notice to the other Party at any time during the term of this Agreement as
follows:

 

  (a)   if the other Party is in breach of any material obligation hereunder by
causes and reasons within its control, or has breached, in any material respect,
any representations or warranties set forth in Article VI, and has not cured
such breach within (i) [*] Business Days in case the breach is a non payment of
any amount due under this Agreement and (ii) within [*] days for other cases of
breach, after notice requesting cure of the breach, provided, however, that if a
breach other than a non payment is not capable of being cured within [*] days of
such written notice, the Agreement may not be terminated sooner than [*] days of
such written notice so long as the breaching Party commences and is taking
commercially reasonable actions to cure such breach as promptly as practicable;
or

 

  (b)   Upon the filing or institution of bankruptcy, reorganization,
liquidation or receivership proceedings, under any re-organization or insolvency
law of any jurisdiction, or upon an assignment of a substantial portion of the
assets for the benefit of creditors by the other Party, or upon the rejection of
this Agreement by either Party under section 365 of 11 U.S.C. §101 et seq. (the
“Bankruptcy Code”); provided, however, that in the case of any involuntary
bankruptcy, reorganization, liquidation, receivership or assignment proceeding
such right to terminate shall only become effective if the Party consents to the
involuntary proceeding or such proceeding is not dismissed within ninety (90)
days after the filing thereof.

 

8.3.2. Licensee Rights Not Affected.

 

  (a)   All rights and licenses granted pursuant to this Agreement are, and
shall otherwise be deemed to be, for purposes of Section 365(n) of the
Bankruptcy Code licenses of rights to “intellectual property” as defined under
Section 101(35A) of the Bankruptcy Code. The Parties agree that INDEVUS and
AVENTIS shall retain and may fully exercise all of their respective rights,
remedies and elections under the Bankruptcy Code.

 

  (b)   The Parties further agree that, in the event of the commencement of a
bankruptcy or reorganization case by or against AVENTIS under the Bankruptcy
Code, INDEVUS shall be

 

*CONFIDENTIAL TREATMENT REQUESTED

 

29

--------------------------------------------------------------------------------

entitled to all applicable rights under Section 365 (including 365(n)) of the
Bankruptcy Code. Upon rejection of this Agreement by AVENTIS or a trustee in
bankruptcy for AVENTIS, pursuant to Section 365(n), INDEVUS may elect (i) to
treat this Agreement as terminated by such rejection or (ii) to retain its
rights (including any right to enforce any exclusivity provision of this
Agreement) to intellectual property (including any embodiment of such
intellectual property) under this Agreement and under any agreement
supplementary to this Agreement for the duration of this Agreement and any
period for which this Agreement could have been extended by INDEVUS. Upon
written request to the trustee in bankruptcy or AVENTIS, the trustee or AVENTIS,
as applicable, shall (i) provide to INDEVUS any intellectual property (including
such embodiment) held by the trustee or AVENTIS and shall provide to INDEVUS a
complete duplicate of (or complete access to, as appropriate) any such
intellectual property and all embodiments of such intellectual property and (ii)
not interfere with the rights of INDEVUS to such intellectual property as
provided in this Agreement or any agreement supplementary to this Agreement,
including any right to obtain such intellectual property (or such embodiment or
duplicates thereof) from a Third Party.

 

8.4 Effect of Expiration or Termination.

 

  (a)   Except as set forth in this Agreement, in the event of termination of
this Agreement, the rights and obligations hereunder, excluding any payment
obligation that has accrued as of the termination date and excluding rights and
obligations relating to confidentiality, shall terminate immediately, except
that INDEVUS and its Affiliates and sublicensees shall have the right to sell or
otherwise dispose of the stock of any Product subject to this Agreement then on
hand or in process of manufacture. Expiration or termination of this Agreement
shall not relieve the Parties of any obligation accruing prior to such
expiration or termination. In addition to any other provisions of this Agreement
which by their terms continue after the expiration of this Agreement, the
provisions of Article IV shall survive the expiration or termination of this
Agreement and shall continue in effect for five (5) years from the date of
expiration or termination. In addition, any other provision required to
interpret and enforce the Parties’ rights and obligations under this Agreement
shall also survive, but only to the extent required for the full observation and
performance of this Agreement. Any expiration or early termination of this
Agreement shall be without prejudice to the rights of any Party against the
other accrued or accruing under this Agreement prior to termination. Except as
expressly set forth herein, the rights to terminate as set forth herein shall be
in addition to all other rights and remedies available under this Agreement, or
at law.

 

  (b)   Upon termination of this Agreement pursuant to Section 8.2 or upon
termination by AVENTIS pursuant to Section 8.3.1(a), INDEVUS shall, if requested
to do so in writing by AVENTIS, grant a license to AVENTIS of INDEVUS Patent
Assets and INDEVUS Know-How including any Regulatory Approval, if any, held by
INDEVUS for Products at the time of termination. The Parties shall negotiate in
good faith to enter into a mutually acceptable license provided, however, that
such license shall be royalty-free if the termination is by INDEVUS under
Section 8.2.

 

30

--------------------------------------------------------------------------------

ARTICLE IX

MISCELLANEOUS

 

9.1 Force Majeure. Neither Party shall be held liable or responsible to the
other Party nor be deemed to have defaulted under or breached the Agreement for
failure or delay in fulfilling or performing any term of the Agreement during
the period of time when such failure or delay is caused by or results from
causes beyond the reasonable control of the affected Party including, but not
limited to, fire, flood, embargo, war, acts of war (whether war be declared or
not), insurrection, riot, civil commotion, strike, lockout or other labor
disturbance, act of God or act, omission or delay in acting by any governmental
authority, provided the affected Party has promptly notified the other Party of
such force majeure circumstances as soon as reasonably practicable, and makes
reasonable efforts to overcome force majeure and minimize the consequences of
the force majeure, and resumes the performance of its obligations as soon as
force majeure terminates.

 

9.2 Assignment. The Agreement may not be assigned or otherwise transferred
without the prior written consent of the other Party; provided, however, that
without such consent (i) either Party may assign this Agreement to an Affiliate,
or in connection with the transfer or sale of all or substantially all of its
business or assets or in the event of a merger, consolidation, change in control
or similar corporate transaction and (ii)AVENTIS may assign this Agreement in
connection with the transfer or sale of all or substantially all of its business
or assets to which the Compound or Product relate, and provided further that the
provisions of Section 2.4 may not be assigned by AVENTIS except to a Qualified
Assignee of AVENTIS’ business and assets to which Compound or Product relate.
For purposes of this Section 9.2, a Qualified Assignee shall mean a company
that, at the time of exercise of the Right of First Negotiation, is actively
engaged in the marketing of pharmaceutical products in those countries of the
European Community where such Right of First Negotiation is meant to be
implemented at that time and has the internal capability to achieve substantial
market penetration and optimize sales of Product in such countries, taking into
account the market potential of the Product and the status of the market as well
as all relevant factors at that time. The Agreement shall be binding and inure
to the successors of either Party thereto, in particular in the event of a
merger, consolidation, change in control or similar corporate transaction. Any
successor or permitted assignee shall assume all obligations of its assignor
under this Agreement.

 

9.3 Severability. In the event that any of the provisions contained in this
Agreement are held invalid, illegal or unenforceable in any respect, the
validity, legality and enforceability of the remaining provisions contained
herein shall not in any way be affected or impaired thereby, unless the invalid
provisions are of such essential importance for this Agreement that it is to be
reasonably assumed that the Parties would not have entered into this Agreement
without the invalid provisions. In such event, the Parties shall substitute such
invalid provisions by valid ones, which in their economic effect come so close
to the invalid provisions that it can be reasonably assumed that the Parties
would have entered into this Agreement also with those substituted provisions.

 

9.4 Notices. All notices or other communications which are required or permitted
hereunder shall be in writing and sufficient if delivered personally, sent by
facsimile (and promptly confirmed by personal delivery, registered or certified
mail or overnight courier), sent by

 

31

--------------------------------------------------------------------------------

nationally-recognized overnight courier or sent by registered or certified mail,
postage prepaid, return receipt requested, addressed as follows:

 

if to INDEVUS to:

 

INDEVUS PHARMACEUTICALS, INC.

99 Hayden Avenue, Suite 200

Lexington, MA, United States 02421

Attention: President

Fax No.: 1-781-862-3859

 

if to AVENTIS to:

 

AVENTIS PHARMA SA

20 avenue Raymond Aron

92165 Antony Cedex

France

Attention: General Counsel

Fax No.: 33 1 55 71 66 50

 

or to such other address as the Party to whom notice is to be given may have
furnished to the other Parties in writing in accordance herewith. Any such
communication shall be deemed to have been given when delivered if personally
delivered or sent by facsimile on a Business Day, upon confirmed delivery by
nationally-recognized overnight courier if so delivered and on the third
Business Day following the date of mailing if sent by registered or certified
mail.

 

9.5 Applicable Law and Dispute Resolution. The Agreement shall be governed by
and construed in accordance with the laws of New York, without reference to any
rules of conflict of laws, except matters of intellectual property law, which
shall be determined in accordance with the national intellectual property laws
relevant to the intellectual property in question.

 

  (a)   The Parties agree to attempt initially to solve all claims, disputes, or
controversies arising under, out of, or in connection with this Agreement (a
“Dispute”) by conducting good faith negotiations. Any Disputes which cannot be
resolved by good faith negotiation within thirty (30) Business Days, shall be
referred, by written notice from either Party to the other, to the Chief
Executive Officer of each Party. Such Chief Executive Officers shall negotiate
in good faith to achieve a resolution of the Dispute referred to them within
thirty (30) Business Days after such notice is received by the Party to whom the
notice was sent. With the exception of issues subject to the provisions of
Section 3.3.2, if the Chief Executive Officers are unable to settle the Dispute
between them within thirty (30) Business Days, they shall so report to the
Parties in writing. The Dispute shall then be referred to mediation as set forth
in the following subsection (b).

 

  (b)   Upon the Parties receiving the Chief Executive Officers’ report that the
Dispute referred to them pursuant to subsection (a) has not been resolved, the
Dispute shall be referred to mediation by written notice from either Party to
the other. The mediation shall be conducted pursuant to the LCIA Mediation
Procedure. In the event INDEVUS is the claimant, the

 

32

--------------------------------------------------------------------------------

mediation shall be held in London, England; in the event AVENTIS is the
claimant, the mediation shall be held in Geneva, Switzerland. If the Parties
have not reached a settlement within twenty (20) Business Days of the date of
the notice of mediation, the Dispute shall be referred to arbitration pursuant
to subsection (c) below.

 

  (c)   If after the procedures set forth in subsections (a) and (b) above, the
Dispute has not been resolved, a Party shall decide to institute arbitration
proceedings, it shall give written notice to that effect to the other Party. The
Parties shall refrain from instituting the arbitration proceedings for a period
of sixty (60) days following such notice. During such period, the Parties shall
continue to make good faith efforts to amicably resolve the dispute without
arbitration. If the Parties have not reached a settlement during that period the
arbitration proceedings shall go forward and be governed by the LCIA Arbitration
Rules then in force. Each such arbitration shall be conducted by a panel of
three arbitrators with appropriate experience in the biotechnology or
pharmaceutical industry: one arbitrator shall be appointed by each of AVENTIS
and INDEVUS and the third arbitrator, who shall be the Chairman of the tribunal,
shall be appointed by the two Party-appointed arbitrators. In the event INDEVUS
is the claimant, the arbitration shall be held in London, England; in the event
AVENTIS is the claimant, the arbitration shall be held in the Geneva,
Switzerland. The arbitrators shall have the authority to grant specific
performance. Judgment upon the award so rendered may be entered in any court
having jurisdiction or application may be made to such court for judicial
acceptance of any award and an order of enforcement, as the case may be. In no
event shall a demand for arbitration be made after the date when institution of
a legal or equitable proceeding based on such claim, dispute or other matter in
question would be barred by the applicable statute of limitations. Each Party
shall bear its own costs and expenses incurred in connection with any
arbitration proceeding and the Parties shall equally share the cost of the
mediation and arbitration levied by the LCIA. Any mediation or arbitration
proceeding entered into pursuant to this Section 9.5 shall be conducted in the
English language.

 

9.6 Entire Agreement. This Agreement, including the exhibits and schedules
hereto, contains the entire understanding of the Parties with respect to the
subject matter hereof and supersedes all previous writings and understandings.
This Agreement may be amended, or any term hereof modified, only by a written
instrument duly executed by all Parties hereto.

 

9.7 Independent Contractors. It is expressly agreed that the Parties shall be
independent contractors and that the relationship between the Parties shall not
constitute a partnership, joint venture or agency. Neither Party shall have the
authority to make any statements, representations or commitments of any kind, or
to take any action, which shall be binding on the other Party, without the prior
consent of such other Party.

 

9.8 Waiver. The waiver by a Party hereto of any right hereunder or the failure
to perform or of a breach by another Party shall not be deemed a waiver of any
other right hereunder or of any other breach or failure by said other Party
whether of a similar nature or otherwise.

 

9.9 Headings. The captions to the several Articles and Sections hereof are not a
part of the Agreement, but are merely guides or labels to assist in locating and
reading the several Articles and Sections hereof.

 

33

--------------------------------------------------------------------------------

9.10 Counterparts. The Agreement may be executed in two or more counterparts,
each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument.

 

9.11 LIMITATION OF LIABILITY. NEITHER PARTY SHALL BE LIABLE TO THE OTHER FOR ANY
SPECIAL, CONSEQUENTIAL, INCIDENTAL OR INDIRECT DAMAGES ARISING OUT OF THIS
AGREEMENT, HOWEVER CAUSED, UNDER ANY THEORY OF LIABILITY.

 

[Remainder of page intentionally left blank]

 

34

--------------------------------------------------------------------------------

IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date
first set forth above.

 

AVENTIS PHARMA SA

 

By:    /s/    GILLES BRISSON                            

Name: Gilles Brisson

Title: President and Chief Executive Officer

 

INDEVUS PHARMACEUTICALS, INC.

 

By:    /s/    GLENN L. COOPER                            

Name: Glenn L. Cooper, M.D.

Title: President and Chief Executive Officer

 

35

--------------------------------------------------------------------------------

EXHIBITS AND SCHEDULES

 

36

--------------------------------------------------------------------------------

SCHEDULE 1.5

 

AVENTIS PATENT ASSETS

 

[*]

 

*CONFIDENTIAL TREATMENT REQUESTED

 

37

--------------------------------------------------------------------------------

SCHEDULE 1.6

 

BANK HOLIDAYS IN FRANCE AND IN U.S.A.

 

FRANCE

 

Wednesday

   January 1 (*)    New Year Day

Monday

   April 21 (**)    Easter Monday

Thursday

   May 1 (*)    Labour Day

Thursday

   May 8 (*)    End of World War II

Thursday

   May 29 (**)    Ascension

Monday

   June 9 (**)    Whit Monday

Monday

   July 14 (*)    National Day

Friday

   August 15 (**)    Assumption

Saturday

   November 1 (*)    All Saints’ Day

Tuesday

   November 11 (*)    End of World War I

Thursday

   December 25 (*)    Christmas

 

(*) Every year on same date

 

(**) Dates are for 2003, but for following years, since they are catholic
religious feasts, they are worldwide identical dates,

 

38

--------------------------------------------------------------------------------

U.S.A.

 

Wednesday

   January 1 —  (1)    New Years Day

Monday

   January 20 —  (2)    Martin Luther King Day

Monday

   February 17 —  (3)    President’s Day

Monday

   May 26 —  (4)    Memorial Day

Friday

   July 4 —  (1)    Independence Day

Monday

   September 1 —  (5)    Labor Day

Monday

   October 13 —  (6)    Columbus Day

Tuesday

   November 11 —  (1)    Veteran’s Day

Thursday

   November 27 —  (7)    Thanksgiving Day

Thursday

   December 25 —  (1)    Christmas Day

 

Notes:

 

ALL dates listed are for 2003

 

(1) Occur every year on the same date

 

(2) Occurs on the third Monday in January every year

 

(3) Occurs on the third Monday in February every year

 

(4) Occurs on the fourth Monday in May every year

 

(5) Occurs on the first Monday in September every year

 

(6) Occurs on the second Monday in October every year

 

(7) Occurs on the fourth Thursday in November every year

 

39

--------------------------------------------------------------------------------

SCHEDULE 1.14

 

DIAGRAM OF HMR 3270

 

[*]

 

*CONFIDENTIAL TREATMENT REQUESTED

 

40

--------------------------------------------------------------------------------

SCHEDULE 1.46

 

SPECIFICATIONS OF NUCLEUS

 

Preliminary Specification

 

(based on [*] data)

 

[*]

 

*CONFIDENTIAL TREATMENT REQUESTED

 

41

--------------------------------------------------------------------------------

SCHEDULE 3.3.1

 

COMMITTEE MEMBERS

 

AVENTIS;

 

[*]

 

INDEVUS:

 

[*]

 

*CONFIDENTIAL TREATMENT REQUESTED

 

42

--------------------------------------------------------------------------------

EXHIBIT 3.3.5

 

ANNUAL DEVELOPMENT PLAN — YEAR 1

 

[*]

 

*CONFIDENTIAL TREATMENT REQUESTED

 

43

--------------------------------------------------------------------------------

EXHIBIT 3.7

 

AVENTIS INVENTORY

 

(BEFORE RE-TESTING AND RE-RELEASE)

 

[*]

 

*CONFIDENTIAL TREATMENT REQUESTED

 

* The exact amount to be provided by AVENTIS to INDEVUS in writing within ten
(10) Business Days after the Effective Date

 

44