EXHIBIT 10.1
 
CONFIDENTIAL TREATMENT
 
AMENDMENT NO. 4
 
to the
 
RESEARCH AGREEMENT dated July 13, 2000
 
between the
 
UNIVERSITY OF SOUTHERN CALIFORNIA
and
MARET CORPORATION
 
June 24, 2002
 
This amendment reflects an increase to the Research Agreement by $[*] (see
Exhibit B) from $[*] to $[*] and defines Research Work to be performed in the
Statement of Work attached and incorporated in this amendment as Exhibit A, for
the period April 1, 2002 through March 31, 2003. The Research Agreement is
revised as follows:
 
ARTICLE 3
Period of Performance, to be revised as follows:
 
The period of performance of this Agreement is 06/30/2000 through 03/31/2003.
This Agreement shall become effective upon the date of last signature hereto and
shall continue in effect for the full duration of the period of performance
unless sooner terminated in accordance with the provisions of Article 14.
 
ARTICLE 4
Reports and Data
 
The Principal Investigator shall furnish Sponsor with (i) written project
protocols prior to undertaking any work under this Research Agreement, (ii)
written summary reports, as needed, and (iii) written reports, including data,
on completion of each project.
 
ARTICLE 5
Costs, Billings and Other Support, to be revised as follows:
 
5.1    It is agreed and understood by the Parties hereto that subject to Article
2, total costs to the SPONSOR hereunder shall not exceed the amount of $[*].
 
Additional payments shall be made by SPONSOR in advance according to the
following schedule:
 
[*]
    
$ [*]
[*]
    
$ [*]
[*]
    
$ [*]

 
All other terms and conditions remain unchanged.
 
IN WITNESS WHEREOF, the parties hereto have executed this Amendment in duplicate
by duly authorized persons.
 
MARET CORPORATION
     
UNIVERSITY OF SOUTHERN CALIFORNIA
By:
 
/s/    Paul J. Mellett        
     
By:
 
/s/    Lloyd Armstrong        
   

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Name:  Paul J. Mellett         
     
Name:  Lloyd Armstrong, Jr.
Title:  CFO
     
Title:  Provost and Senior Vice President, Academic Affairs
Date:  7/3/02
     
Date:  6/27/2002

 
*
 
Confidential Treatment Requested. Omitted Portions filed with the Commission.

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EXHIBIT A
 
Statement of Work
Period April 1, 2002 through March 31, 2003
 
[*]
 
 
 
 
*
 
Confidential Treatment Requested. Omitted Portions filed with the Commission.

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EXHIBIT B
 
Principal Investigator: Gere S. diZerega, M.D.,
MARET CORPORATION
[*]
Period of Performance April 1, 2002 through March 31, 2003
 
[*]
 
 
 
 
*
 
Confidential Treatment Requested. Omitted Portions filed with the Commission.