Exhibit 10.2

***Denotes certain parts that have not been disclosed and have been filed
separately with the Secretary, Securities and Exchange Commission, and is
subject to a confidential treatment request pursuant to Rule 24b-2 of the
Securities Exchange Act of 1934.

ASSET PURCHASE AGREEMENT

This ASSET PURCHASE AGREEMENT (this “Agreement”) is entered into as of
January 27, 2006 (the “Effective Date”), by and between Raptor Pharmaceutical
Inc., a Delaware corporation (“Raptor”), and BioMarin Pharmaceutical Inc., a
Delaware corporation (“BioMarin”). BioMarin and Raptor are each referred to
herein individually as a “Party” and collectively as the “Parties.”

RECITALS

WHEREAS, BioMarin is the owner of the Business (as defined below) as operated
prior to the Effective Date and of the Transferred Technology (as defined
below); and

WHEREAS, Raptor desires to acquire from BioMarin, and BioMarin desires to assign
to Raptor, the Transferred Technology on the terms and conditions set forth in
this Agreement.

AGREEMENT

NOW, THEREFORE, in consideration of the mutual promises contained herein and
intending to be legally bound, the Parties agree as follows:

 

1.

Definitions.

1.1          Construction. For all purposes of this Agreement, except as
otherwise expressly provided:

 

(a)

the terms defined in this Agreement include the plural as well as the singular,

 

(b)

all references in this Agreement to designated “Articles,” “Sections,” and other
subdivisions are to the designated Articles, Sections and other subdivisions of
the body of this Agreement, and all references to “Exhibits” and “Schedules” are
to the Exhibits and Schedules attached to this Agreement,

 

(c)

pronouns of either gender or neuter shall include, as appropriate, the other
pronoun forms,

 

(d)

the words “include” and “including” when used herein are not exclusive and mean
“include, without limitation” and “including, without limitation,” respectively,
and

 

 

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(e)

the words “herein,” “hereof” and “hereunder” and other words of similar import
refer to this Agreement as a whole and not to any particular Article, Section or
other subdivision.

1.2          Defined Terms. As used in this Agreement and the Exhibits and
Schedules, the following definitions shall apply:

 

(a)

“Action” means with respect to any specified person any action, complaint,
petition, investigation, suit, arbitration or other proceeding, whether civil or
criminal, in law or in equity, or before any arbitrator or Governmental Entity.

 

(b)

“Affiliate” means with respect to any specified Person, a Person that directly,
or indirectly through one or more intermediaries, controls, or is controlled by,
or is under common control with the Person specified.

 

(c)

“Alternate Milestone Payment Schedule” shall mean payment of one-fourth of the
applicable Milestone Fee within 15 days of the milestone event, another
one-fourth within 90 days of the event, another one-fourth within 180 days of
the event and the final one-fourth of the applicable Milestone Fee within 270
days of the applicable milestone event.

 

(d)

“Approval” means any approval, authorization, assignment or consent,
qualification or registration, or any waiver of any of the foregoing, required
to be obtained from, or any notice, statement or other communication required to
be filed with or delivered to, any Person, the receipt of which is necessary to
approve the Transactions or to the transfer of and continued operation of the
Business by Raptor as it has been operated prior to the Effective Date.

 

 

(e)

“Business” means (i) the research and development activities of, or under
authority of, BioMarin, Raptor or their Affiliates, which activities directly
and specifically relate to the use of a receptor associated protein, or any
similar or related protein, as a drug or drug delivery platform, including the
Technology necessary for such research and development activities and (ii) the
further research and development concerning such use beyond the research and
development activities described in clause (i) and the commercial exploitation
of all of the foregoing research and development; including all further
research, development, making, use, license, import and sale of products that
involve or use such a protein.

 

 

 

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(f)

“Business Copyrights” shall mean the Copyrights listed on Section 1.2(g) of the
Disclosure Schedule.

 

(g)

“Business Patents” shall mean the Patents listed on Section 1.2(h) of the
Disclosure Schedule and all patents, utility models, certificates of invention,
patents of addition or substitution, and other governmental grants for the
protection of inventions anywhere in the world, including any reissue, renewal,
re-examination, or extension thereof, and all applications for any of the
foregoing, including any international, regional, national, provisional,
divisional, continuation, continuation in part, continued prosecution, and petty
patent application, in each case that correspond or that claim priority to the
Patents listed on Section 1.2(h) of the Business Disclosure Schedule.

 

(h)

“Business Trademarks” shall mean the Trademarks listed on Section 1.2(i) of the
Disclosure Schedule and all goodwill associated with such Trademarks.

 

(i)

“Copyrights” shall mean U.S. and foreign registered and unregistered copyrights
(including those in computer software and databases), rights of publicity and
all registrations and applications to register the same.

 

(j)

“Disclosure Schedule” shall mean the disclosure schedule of even date herewith
prepared and signed by BioMarin and delivered to Raptor simultaneously with the
execution hereof.

 

(k)

“Dispute” has the meanings specified in Section 12.3(a).

 

(l)

“EMEA” means the European Medicines Agency or any successor agency.

 

(m)

“Encumbrance” means any claim, charge, easement, encumbrance, lease, covenant,
security interest, lien, option, pledge, rights of others (including, but not
limited to, licenses, exclusivity, options and rights of first refusal, of
discussion, or negotiation), or restriction (whether on sale, transfer,
disposition or otherwise), whether imposed by agreement, understanding, law,
equity or otherwise.

 

(n)

“Escalation Notice” has the meaning specified in Section 12.3(a).

 

(o)

“FDA” means the United States Food and Drug Administration or any successor
agency vested with administrative and regulatory authority to approve testing
and marketing of human pharmaceutical or biological therapeutic or diagnostic
products in the United States.

 

 

 

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(p)

“Governmental Entity” means any government or any agency, bureau, board,
commission, court, department, official, political subdivision, tribunal or
other instrumentality of any government, whether federal, state or local,
domestic or foreign.

 

(q)

“Improvement” means any carrier protein that has at least seventy five percent
(75%) homology with the Receptor Associated Protein. As used herein, “at least
seventy five percent (75%) homology” means the nucleotide or amino acid residue
sequence is at least seventy five percent (75%) identical to the amino acid
sequence of the Receptor Associated Protein.

 

(r)

“Intellectual Property” shall mean all rights in, to and under any and all of
the following: Trademarks, Patents, Copyrights, Trade Secrets, Technology and
other intellectual property and proprietary rights anywhere in the world.

 

(s)

“Investigational New Drug Application” shall mean an investigational new drug
application, as defined in 21 C.F.R. Section 312.3, obtained for purposes of
conducting clinical trials in accordance with the requirements of the United
States Federal Food, Drug and Cosmetic Act and the regulations promulgated
thereunder, including all supplements and amendments thereto.

 

(t)

“Law” means any constitutional provision, statute or other law, rule,
regulation, or interpretation of any Governmental Entity and any Order.

 

(u)

“Transferred Know-How” shall mean all Technology in the possession or control of
BioMarin or its Affiliates necessary for the Business, which shall include all
Technology listed in Section 1.2(v) of the Disclosure Schedule.

 

(v)

“Transferred Technology” shall mean all Intellectual Property which is owned by
BioMarin or its Affiliates and which is reasonably necessary for the operation
of the Business, or the making, use, sale, offer for sale, or import of any
Products, which shall include: (i) the Business Patents; (ii) the Business
Trademarks; (iii) the Business Copyrights, (iv) the Transferred Know-How, and
(v) all Products.

 

(w)

“Major Market” shall mean the United States of America, Germany, France, Italy,
Spain, the United Kingdom, Japan, Australia, or the European Union (but only for
clinical trials submitted to, and Marketing Approvals from, the EMEA for the
centralized procedure in which the Marketing Approval from the EMEA is for all
countries in the European Union).

 

 

 

-4-

 

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(x)

“Marketing Approval” shall mean, with respect to a particular NeuroTrans Product
and country, approval by the applicable Regulatory Agencies in such country of a
Marketing Approval Application filed in such country, permitting the NeuroTrans
Product to be marketed and sold in that country for the indications for which
approval is sought, including, if applicable, approval of pricing or
reimbursement.

 

(y)

“Marketing Approval Application” shall mean, with respect to a particular
NeuroTrans Product and country, a marketing authorization application (including
and equivalent to an NDA in the United States), including all supporting
documentation and data submitted for such application to be accepted for review
or approval, filed with the requisite Regulatory Agency of such country and
requesting approval for marketing and/or commercialization of such NeuroTrans
Product for a particular indication in such country.

 

(z)

“Milestone Fee” shall have the meaning set forth in Section 3 below.

 

(aa)

“NDA” shall mean a new drug application to permit commercial marketing of a
NeuroTrans Product in the United States, pursuant to section 505 of the United
States Federal Food, Drug and Cosmetic Act, and the regulations promulgated
thereunder, as amended from time to time, as submitted to the FDA.

 

(bb)

“Net Sales” shall mean the total payments actually received by Raptor or its
Affiliate (the “Seller”) from a non-Affiliate third party on sales of a
NeuroTrans Product by the Seller to such non-Affiliate third party, less the
following: (i) all trade, cash and quantity credits, discounts, refunds or
rebates given by the Seller; (ii) amounts for claims, allowances or credits for
returns, retroactive price reductions, charge-backs, recalls or destroyed goods,
given by Seller; (iii) packaging, handling fees and prepaid freight, sales
taxes, duties and other governmental charges (including value added and other
tax) paid to the Seller; and (iv) quality assurance and quality control costs
relating to the NeuroTrans Product or its preparation paid by the Seller. For
purposes of the foregoing, it is understood that Net Sales shall not include
charges related to services performed in connection with the sale of such
NeuroTrans Products. For the removal of doubt, Net Sales shall not include
transfers among Raptor and its Affiliates.

 

 

 

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(cc)

“NeuroTrans Net Revenue” shall mean the sum of the Net Sales and Sublicensing
Revenue received by Raptor and its Affiliates for NeuroTrans Products.

 

(dd)

“NeuroTrans Product” means a therapeutic product that is delivered across a
blood brain barrier using a carrier protein that facilitates transport of such
therapeutic product across such barrier, but only if (a) the manufacture, sale,
import, offer to sell, use, or other activities with respect to such product
would, but for the assignment to Raptor in Section 2.1 below, infringe in the
country for which such product is sold, a Valid Claim; (b) the manufacture,
sale, import, offer to sell, use, or other activities with respect to such
product would, but for the assignment to Raptor in Section 2.1 below, infringe
upon some or all of the Transferred Know-How, provided that the carrier protein
is the Receptor Associated Protein or an Improvement; or (c) such product is
otherwise based upon the Transferred Technology and the carrier protein is the
Receptor Associated Protein or an Improvement.

 

(ee)

“Order” means any decree, injunction, judgment, order, ruling, assessment or
writ of a Governmental Entity.

 

(ff)

“Patents” shall mean all patents, utility models, certificates of invention,
patents of addition or substitution, and other governmental grants for the
protection of inventions anywhere in the world, including any reissue, renewal,
re-examination, or extension thereof, and all applications for any of the
foregoing, including any international, regional, national, provisional,
divisional, continuation, continuation in part, continued prosecution, and petty
patent applications.

 

(gg)

“Person” means an association, a corporation, an individual, a partnership, a
trust (or trustee thereof, as applicable), or any other entity or organization,
including a Governmental Entity.

 

(hh)

“Products” means all products, Technology and services of BioMarin or its
Affiliates, along with collateral materials of BioMarin and its Affiliates,
researched, developed, sold, licensed, used, or otherwise exploited or
commercialized by BioMarin or any of its Affiliates in the Business, whether
commercially available or in the development stage (including any pre-clinical
and clinical research or development).

 

(ii)

“Receptor Associated Protein” means the receptor associated protein, as
disclosed in and having the sequence disclosed in U.S. Patent No. 5,474,766.

 

 

 

-6-

 

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(jj)

“Regulatory Agency” means (a) the FDA, (b) the EMEA, or (c) any other
Governmental Entity with regulatory authority comparable to the FDA or the EMEA
in any other jurisdiction anywhere in the world.

 

(kk)

“Licensing Revenue” means the net license issuance fees; license maintenance
fees; and milestone payments paid upon completion of a regulatory milestone,
commercial launch, or similar milestone; royalties; and all other similar
revenue; in each case actually received by Raptor and its Affiliates from a
Licensee as consideration for the grant to such Licensee of a license under a
Valid Claim, or otherwise under the Transferred Technology, to make and sell
NeuroTrans Products, excluding (i) all amounts paid to Raptor and its Affiliates
for purchases of any products, services, equity, other securities, or other
items; (ii) any cost sharing or reimbursements; (iii) amounts paid for
facilities or equipment; (iv) loans; dividends; profit distributions and amounts
that are creditable by the Licensee against other payments; (v) payments for
rights or licenses under Technology or Intellectual Property, other than the
Transferred Technology, (such as payments for any other Intellectual Property or
Technology owned by Raptor or its Affiliates) and payments based upon products
other than NeuroTrans Products; (vi) all amounts paid in connection with a sale
of all or substantially all of the business or assets of Raptor or its
Affiliates related to this Agreement; and (vii) non-cash consideration.
Notwithstanding the foregoing, Licensing Revenue (A) shall be reduced by the
amount of any cash payments to third parties in respect of the amounts received
by Raptor and its Affiliates (including, without limitation, royalties on the
same products paid to third parties under technology in-licenses); and (B) shall
be net of any applicable taxes and other amounts credited or deducted against
the amounts actually paid to Raptor and its Affiliates.

 

(ll)

“Licensee” means an entity to which Raptor has granted a license under a Valid
Claim to make and sell NeuroTrans Products.

 

(mm)

“Security Agreement” means that certain “Security Agreement” entered into by and
between the Parties on even date herewith, to secure the payments to BioMarin
that become due and payable under this Agreement.

 

(nn)

“Successful Completion” shall mean, with respect to a phase II or phase III
clinical study, (i) completion of the final clinical trial report for the
clinical study provided that the data from the clinical study demonstrates that
the primary endpoints in the study protocol have been met; or (ii) the
initiation of the next phase of

 

 

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development (i.e. the initiation of a phase III trial for the same therapeutic
for which the phase II study has been conducted, and in the case of completion
of a phase II trial or phase III trial, the filing of a Marketing Approval
Application to obtain Marketing Approval for the same product.

 

(oo)

“Tax” means any United States federal, state, local, or foreign taxes, and
assessments of a similar nature (whether imposed directly or through
withholding), including any interest, penalty, or addition thereto.

 

(pp)

“Technology” means any and all technology, and technical and other information,
and tangible embodiments thereof, including Trade Secrets, know-how, research,
processes, formulations, techniques, diagnostics, models, concepts, ideas,
knowledge, developments, samples, methods, invention and other disclosures,
recipes, specifications, materials, instructions, compositions, designs,
results, assays, reagents, systems, descriptions, analyses, opinions, works of
authorship, plans, procedures, manuals, depictions, inventions, discoveries,
methods, data, reports, market information, projections, and any other written,
printed or electronically stored information and materials of any nature
whatsoever.

 

(qq)

“Term” shall have the meaning set forth in Section 11.1.

 

(rr)

“Territory” shall mean all countries, territories, and other regions of the
world.

 

(ss)

“Trademarks” shall mean U.S. and foreign registered and unregistered trademarks,
trade dress, service marks, logos, trade names, corporate names and all
registrations and applications to register the same and all goodwill associated
with any of the foregoing.

 

(tt)

“Trade Secrets” shall mean all categories of trade secrets as defined in the
Uniform Trade Secrets Act, including trade secrets that are business
information, inventions, know-how, or confidential information.

 

(uu)

“Transactions” shall mean the transactions and activities provided for or
contemplated by this Agreement.

 

(vv)

“Valid Claim” means (i) an issued, unexpired, and enforceable claim in the
Business Patents, or any other Patent assigned to Raptor in the Transferred
Technology, that has an effective filing date (as defined in 35 USC §119 or
§120, or equivalent in a country outside the United States) that precedes the
Effective Date

 

 

-8-

 

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or (ii) an issued, unexpired, and enforceable claim in another Patent owned by
Raptor that claims, and is primarily directed to, an Improvement (and not any
protein more generally); in each case provided that the claim has not been held
invalid or unenforceable, and has not been abandoned, disclaimed, waived, or
terminated.

 

2.

Assignment.

2.1          Assignment. Subject to the terms and conditions of this Agreement,
BioMarin hereby assigns, transfers, conveys, and delivers to Raptor, and Raptor
hereby accepts and acquires from BioMarin, all right, title and interest in, to
and under the Transferred Technology.

2.2          Licensees. Raptor shall promptly advise BioMarin of any license of
the Transferred Technology to any Licensee. Raptor’s grant of any license shall
not relieve Raptor of its obligations under this Agreement.

2.3          Exclusivity. Without limiting the assignment in Section 2.1,
BioMarin and its Affiliates shall not, directly or indirectly (and shall not
authorize any other party to), market, develop, make, have made, use, sell,
offer to sell, or distribute any product, component or service that is
Transferred Technology or is covered by the Transferred Technology, including
any product, component or service in a non-Patent country that would infringe a
Patent in the Transferred Technology if made, used, sold, or imported in a
country in which a Patent in the Transferred Technology exists, or otherwise
use, disclose or exploit the Transferred Technology, anywhere in the world.

2.4          Liabilities Assumed and Not Assumed. Raptor does not assume, shall
not take subject to and shall not be liable for, any liabilities or obligations
of any kind or nature, whether absolute, contingent, accrued, known or unknown,
of BioMarin or any Affiliate of BioMarin regardless of when incurred. Raptor
does not assume any liability for failure of BioMarin to obtain a required
consent or approval for the Transactions. BioMarin shall remain liable for all
payments to all suppliers to the Business, and for all accounts payable relating
to the Business, as of the Effective Date.

2.5          No Implied Rights or Obligations. Neither Party shall have any
implied rights or implied obligations in connection with this Agreement. Rather,
each Party’s rights and obligations shall be solely as expressly set forth in
this Agreement.

3.            Milestone Payments. As partial consideration for the assignment to
Raptor in Section 2.1, Raptor shall pay to BioMarin the following amounts (the
“Milestone Fees”) for the achievement of each applicable event:

3.1          Within thirty (30) days after Raptor receives total aggregate debt
or equity financing of at least two million five hundred thousand dollars
($2,500,000), Raptor shall pay BioMarin fifty thousand dollars ($50,000);

 

 

 

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3.2          Within thirty (30) days after Raptor receives total aggregate debt
or equity financing of at least five million dollars ($5,000,000), Raptor shall
pay BioMarin one hundred thousand dollars ($100,000);

3.3          Upon the filing and acceptance by any Regulatory Agency of an
Investigational New Drug Application for a NeuroTrans Product of Raptor, its
Affiliate or a Sublicensee, Raptor shall pay BioMarin five hundred thousand
dollars ($500,000) in accordance with the Alternate Milestone Payment Schedule;

3.4          Upon Successful Completion by Raptor or its Sublicensee of a
(i) phase II human clinical trial for a NeuroTrans Product for the purposes of
collecting data on dosages, evaluating safety and/or collecting preliminary
information regarding efficacy as such trial is more fully defined in 21 C.F.R.
§ 312.21(b), Raptor shall pay BioMarin two million five hundred thousand dollars
($2,500,000) in accordance with the Alternate Milestone Payment Schedule;

3.5          Upon Successful Completion by Raptor or its Sublicensee of (i) a
phase III human clinical trial for a NeuroTrans Product which clinical trial,
when considered either alone or together with one or more clinical trials of
comparable design and end-points that have been completed, has generated
efficacy data sufficient to obtain Marketing Approval by the FDA or an
equivalent agency in a Major Market for the therapeutic, as such clinical trial
is more fully defined in 21 C.F.R. § 312.21(c), Raptor shall pay BioMarin five
million dollars ($5,000,000) in accordance with the Alternate Milestone Payment
Schedule;

3.6          Within ninety (90) days after Raptor or its Affiliate or
Sublicensee obtains Marketing Approval from a Regulatory Agency of a Marketing
Approval Application in a Major Market for a NeuroTrans Product, Raptor shall
pay BioMarin twelve million dollars ($12,000,000);

3.7          Within ninety (90) days after Raptor or its Affiliate or
Sublicensee obtains Marketing Approval from a Regulatory Agency of a Marketing
Approval Application in a Major Market for any NeuroTrans Product(other than the
NeuroTrans Product for which a payment is made under Section 3.6), it being
understood that filings in different countries for the same NeuroTrans Product
shall not trigger the milestone under this Section 3.7, Raptor shall pay
BioMarin five million dollars ($5,000,000);

3.8          Within sixty (60) days after the end of the first calendar year in
which Raptor’s aggregate NeuroTrans Net Revenue actually received by Raptor and
its Affiliates in such calendar year for all NeuroTrans Products exceeds one
hundred million dollars ($100,000,000), Raptor shall pay BioMarin five million
dollars ($5,000,000); and

3.9          Within sixty (60) days after the end of the first calendar year in
which Raptor’s aggregate NeuroTrans Net Revenue actually received by Raptor and
its Affiliates in such calendar year for all NeuroTrans Products exceeds five
hundred million dollars ($500,000,000), Raptor shall pay BioMarin twenty million
dollars ($20,000,000).

For the avoidance of doubt, with the exception of the milestone provided for in
Section 3.7, which may be earned multiple times, none of the above Milestone
Fees may be earned more than once. In particular, if a Milestone Fee is paid
under any of Sections 3.1, 3.2, 3.3, 3.4, 3.5, 3.6,

 

 

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3.8, or 3.9 for any NeuroTrans Product, no further fee shall be payable at any
time under the applicable section, regardless of the product, indication, or
country. Additionally, only one fee shall be payable under Section 3.7 for each
NeuroTrans Product, regardless of the number of countries in which approval is
obtained.

Raptor shall provide full disclosure to BioMarin of each of the events described
in this Section 3 prior to, concurrently with, or immediately after the
occurrence of each event, whichever is possible to do using Raptor’s reasonable
commercial efforts.

 

4.

Royalties.

4.1          Subject to the terms and conditions of this Agreement, as
additional consideration for the assignment to Raptor in Section 2.1, during the
Term (defined below) of this Agreement Raptor agrees to pay to BioMarin a
royalty at the percentages of NeuroTrans Net Revenue actually received by Raptor
and its Affiliates as set forth in this Section 4.1:

 

(a)

*** percent (***%) of NeuroTrans Net Revenue received by Raptor or its
Affiliates for NeuroTrans Product, if the sale or use of the NeuroTrans Product
would, but for the assignment to Raptor in Section 2.1, infringe one or more
Valid Claims in the country for which the NeuroTrans Product is sold; and

 

(b)

*** percent (***%) of NeuroTrans Net Revenue received by Raptor or its
Affiliates for other NeuroTrans Products.

For clarity, if Licensing Revenue is based upon activities (e.g. a license,
clinical trials, regulatory filings or approvals, or the like) for a NeuroTrans
Product for a particular country, the rate in Section 4.1(a) shall apply only if
the sale or use of such NeuroTrans Product would, absent the assignment to
Raptor in Section 2.1, infringe a Valid Claim in that country.

4.2          Notwithstanding the foregoing, no payments shall be due or payable
under Section 4.1 unless the NeuroTrans Net Revenue is received after the
earlier of: (i) the third anniversary of the Effective Date; or (ii) Raptor and
its Affiliates having received after the Effective Date a total aggregate amount
of five million US dollars ($5,000,000) of NeuroTrans Net Revenue. For clarity,
if (ii) is the earlier to occur, no amounts shall be due or payable under
Section 4.1 based upon the initial five million US dollars ($5,000,000) of
NeuroTrans Net Revenue that were received by Raptor and its Affiliates. No more
than one royalty shall be due or payable to BioMarin for any NeuroTrans Product
pursuant to Section 4.1. Section 4.1 shall terminate, and have no further force
or effect, on the twentieth (20th) anniversary of the Effective Date.

4.3          So long as BioMarin, or any successor or assign under this
Agreement, is domiciled in the United States or any other country that has
entered into a tax treaty with the United States such that Raptor is not
required to withhold or pay Taxes on the amounts payable by Raptor under this
Agreement, such payments will be made without deduction or offset for Taxes or
Tax withholding. If BioMarin, or its successor or assign under this Agreement,
is domiciled in any other country, Raptor, in its reasonable discretion, if
required by such country, shall be entitled to make any deduction or withholding
payment for or on account of Taxes or

 

 

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other governmental charges imposed by a jurisdiction in connection with the
payments under this Agreement and shall be entitled to reduce its payment under
this Agreement by the amount of such Taxes.

4.4          Within ninety (90) days after the end of each calendar quarter
during the Term, Raptor shall provide written reports to BioMarin describing in
reasonable detail any NeuroTrans Net Revenues received by Raptor and its
Affiliates during the preceding calendar quarter. Raptor shall not be required
to provide a report if there are no NeuroTrans Net Revenues to report. The
amounts payable by Raptor under Section 4.1 shall be paid concurrent with such
reports. All amounts set forth in this Agreement, or in any Exhibit, are in U.S.
Dollars. If any currency conversion shall be required in connection with the
calculation of royalties hereunder, such conversion shall be made using the
average of the buying and selling exchange rate for the foreign currency, in
U.S. Dollars, quoted for current transactions reported the Chase Manhattan Bank
for the last business day of the calendar quarter to which such payment
pertains.

4.5          For clarity, no payments shall be due to BioMarin under this
Agreement for the sale of any inventory of NeuroTrans Products as part of the
sale of all or substantially all of Raptor’s and/or its Affiliates business or
assets related to this Agreement, whether by way of merger, acquisition of
assets, operation of the law, or otherwise, provided that this Section 4.5 shall
not relieve any such asset purchaser, successor or assign under this Agreement,
in any such transaction, from otherwise being obligated to make payments to
BioMarin as a result of its subsequent sale or distribution of such NeuroTrans
Products pursuant to this Agreement.

5.            Representations And Warranties Of BioMarin. Except as specifically
set forth in the Disclosure Schedule prepared by BioMarin and delivered to
Raptor simultaneously with the execution hereof, BioMarin represents and
warrants to Raptor as of the Effective Date as follows:

5.1          Organization and Related Matters. BioMarin is a corporation duly
organized, validly existing and in good standing under the laws of the State of
Delaware. BioMarin has all necessary corporate power and authority to own its
properties and assets and to carry on the Business and the other businesses of
BioMarin as now conducted.

5.2          Authorization; Binding Agreement. BioMarin has full corporate power
and authority to execute and deliver this Agreement and to consummate the
Transactions. The execution, delivery and performance by BioMarin of this
Agreement and the consummation by it of the Transactions have been duly
authorized by BioMarin’s Board of Directors, and no other corporate action on
the part of BioMarin is necessary to authorize the execution and delivery by
BioMarin of this Agreement or the consummation by it of the Transactions. This
Agreement has been duly executed and delivered by BioMarin and, assuming due and
valid authorization, execution and delivery thereof by Raptor, this Agreement is
the valid and binding obligation of BioMarin enforceable against BioMarin in
accordance with its terms, except (i) as limited by applicable bankruptcy,
insolvency, reorganization, moratorium, fraudulent conveyance and other similar
laws of general application affecting enforcement of creditors’ rights generally
and (ii) the availability of the remedy of specific performance or injunctive or
other forms of equitable relief may be subject to equitable defenses and would
be subject to the discretion of the court before which any proceeding therefor
may be brought.

 

 

 

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5.3          Conflicts. The execution, delivery and performance of this
Agreement by BioMarin and the consummation by it of the Transactions will not
conflict with or result in a breach or violation of any term or provision of, or
(with or without notice or passage of time, or both) constitute a breach or
default under, the charter or bylaws of BioMarin or agreement to which BioMarin
or its Affiliate is a party, or to BioMarin’s knowledge, violate any Law or
Order of any Governmental Entity or any arbitrator, having jurisdiction over
BioMarin or the Business or result in any Encumbrance on any Transferred
Technology. The execution, delivery and performance of this Agreement by
BioMarin and the consummation by it of the Transactions will not require filing
or registration with, or the issuance of any permit or Approval by, any other
third party or Governmental Entity under the terms of any applicable Laws or
contracts to which BioMarin is a party.

5.4          Rights to Transferred Technology. BioMarin has all right, power and
authority to enter into this Agreement and make the assignments to Raptor in
accordance with the terms of this Agreement, and BioMarin and its Affiliates
have not entered into any inconsistent or conflicting agreements, or granted any
inconsistent or conflicting rights or exclusivity.

5.5          Legal Proceedings. To the knowledge of BioMarin, there is no Order
or Action pending, or threatened, against or affecting BioMarin or related to
any aspect of the Business, the Transferred Technology, or the use or operation
thereof, or BioMarin’s ability to perform this Agreement or any aspect of the
Transactions.

5.6          Restrictions on Business Activities. To BioMarin’s knowledge, there
is no agreement (not to compete or otherwise), commitment, judgment, injunction,
order or decree to which BioMarin or its Affiliate is a party relating to the
Business or Products or otherwise binding upon BioMarin or its Affiliate or the
Business or Products which has or may have the effect of prohibiting or
impairing the transactions contemplated by this Agreement or any activities of
the Business, or any licensing or sublicensing of the Transferred Technology.
BioMarin and its Affiliates have not entered into any agreement under which the
operations of the Business are restricted or which places any restrictions upon
BioMarin or its Affiliates with respect to using, selling, licensing or
otherwise distributing the Transferred Technology or Business.

 

5.7

Intellectual Property.

 

(a)

BioMarin or its Affiliates are the sole owners of, and have good title to, all
of the Patents, Copyrights and Trademarks listed in Sections 1.2(g), 1.2(h), or
1.2(i) of the Disclosure Schedule. All such Intellectual Property has been
assigned to BioMarin and its Affiliates, and all such assignments have been
properly recorded at least ninety (90) days prior to the Effective Date. Each
item of Transferred Technology is free and clear of all Encumbrances. Without
limiting the foregoing, BioMarin exclusively owns, and has good title to, all
Transferred Technology; no other Person has any rights, title or interests
therein or thereto (other than the rights granted to Raptor under this
Agreement). All Transferred

 

 

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Technology shall be fully sublicensable by Raptor upon the Effective Date.

 

(b)

BioMarin and its Affiliates have not transferred ownership of, or granted any
license of or right to use, or authorized the retention of any rights to use or
other Encumbrance in, any Transferred Technology, or other Technology or
Intellectual Property that is necessary for the Business, to any Person (other
than the right, title and interest assigned to Raptor under this Agreement).

 

(c)

To BioMarin’s knowledge, BioMarin and its Affiliates have not received any
notice, written or otherwise, from any other Person pertaining to or challenging
any right, title, or interest of BioMarin or its Affiliates with respect to any
of the Transferred Technology. BioMarin has not made any claim of a violation or
infringement by others of its rights to or in connection with the Transferred
Technology which are still pending and is not aware of any infringement of the
Transferred Technology.

 

(d)

To BioMarin’s knowledge, BioMarin and its Affiliates have and enforce a policy
requiring each employee and consultant of BioMarin and its Affiliates to execute
a proprietary rights and confidentiality agreement, and all current and former
employees and consultants of BioMarin and its Affiliates who have created or
modified any of the Transferred Technology have executed such an agreement
assigning all of such employees’ and consultants’ rights in and to the
Transferred Technology to BioMarin. BioMarin is not aware of any unauthorized
use or disclosure of any Trade Secrets that have been used in, or were generated
in or for, the Business.

 

(e)

To BioMarin’s knowledge, no Transferred Technology is subject to any proceeding
or outstanding decree, order, judgment, agreement, or stipulation that restricts
in any manner the use, transfer or licenses thereof, or may affect the validity,
use, or enforceability of the Transferred Technology.

 

(f)

Neither this Agreement, nor the Transactions, will result in Raptor or its
Affiliates being obligated to pay any royalties or other amounts to any third
party (other than the amounts expressly due hereunder to an assignee or
successor to this Agreement).

5.8          Accuracy of Information. To BioMarin’s knowledge, all information
provided by BioMarin in this Agreement and the Disclosure Schedule is true and
complete in all material respects and does not contain any untrue statement of a
material fact or omit to state a material fact necessary to make any statement
therein not misleading.

 

 

 

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5.9          Powers of Attorney. BioMarin has not given any power of attorney
(irrevocable or otherwise) to any Person for any purpose relating to the
Business or the Transferred Technology, other than powers of attorney given to
regulatory authorities in routine qualifications to do business.

6.            Representations And Warranties Of Raptor. Raptor hereby represents
and warrants to BioMarin as of the Effective Date as follows:

6.1          Organization and Related Matters. Raptor is a corporation duly
organized, validly existing and in good standing under the laws of the State of
Delaware. Raptor has all necessary power and authority to own its properties and
assets and to carry on its business as now conducted. Raptor is presently
qualified to do business as a foreign corporation in each jurisdiction where the
failure to be so qualified could reasonably be expected to have a material
adverse effect on Raptor’s financial condition or business as now conducted.

6.2          Authorization; Binding Agreement. Raptor has full power and
authority to execute and deliver this Agreement and to consummate the
Transactions. The execution, delivery and performance of this Agreement by
Raptor and the consummation by it of the Transactions has been duly authorized
by Raptor, and no other action on the part of Raptor is necessary to authorize
the execution and delivery by Raptor of this Agreement or the consummation by it
of the Transactions. This Agreement has been duly executed and delivered by
Raptor, and assuming due and valid authorization, execution and delivery thereby
by BioMarin, this Agreement constitutes a valid and binding obligation of
Raptor, enforceable against Raptor in accordance with its terms, except (i) as
limited by applicable bankruptcy, insolvency, reorganization, moratorium,
fraudulent conveyance and other similar laws of general application affecting
enforcement of creditors’ rights generally and (ii) the availability of the
remedy of specific performance or injunctive or other forms of equitable relief
may be subject to equitable defenses and would be subject to the discretion of
the court before which any proceeding therefor may be brought.

6.3          No Conflicts. The execution, delivery and performance of this
Agreement by Raptor and the consummation by it of the Transactions will not
conflict with or result in a breach or violation of any term or provision of, or
(with or without notice or passage of time, or both) constitute a breach or
default under, the charter documents of Raptor, or any material contract of
Raptor, or violate any Law or Order of any Governmental Entity or any
arbitrator, having jurisdiction over Raptor.

7.            LIMITED WARRANTY. EXCEPT AS EXPRESSLY SET FORTH IN THIS AGREEMENT,
THE TRANSFERRED TECHNOLOGY IS PROVIDED TO RAPTOR ON AN “AS IS” BASIS, AND
BIOMARIN MAKES NO EXPRESS OR IMPLIED REPRESENTATIONS OR WARRANTIES TO RAPTOR
REGARDING THE USABILITY, CONDITION, OR OPERATION OF THE TRANSFERRED TECHNOLOGY.
SIMILARLY, EXCEPT AS EXPRESSLY SET FORTH IN THIS AGREEMENT, RAPTOR MAKES NO
REPRESENTATIONS OR WARRANTIES. NEITHER PARTY WARRANTS THAT USE OF THE
TRANSFERRED TECHNOLOGY WILL MEET ANY PARTICULAR CRITERIA OF PERFORMANCE OR
QUALITY. EACH PARTY HEREBY EXPRESSLY DISCLAIMS ANY AND ALL IMPLIED WARRANTIES,
INCLUDING, WITHOUT LIMITATION,

 

 

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WARRANTIES OF MERCHANTABILITY, TITLE, FITNESS FOR A PARTICULAR PURPOSE,
NON-INFRINGEMENT, COMPATIBILITY, SECURITY, OR ACCURACY. EXCEPT AS OTHERWISE SET
FORTH IN THIS AGREEMENT, USE OF THE TRANSFERRED TECHNOLOGY IS ENTIRELY AT
RAPTOR’S OWN RISK.

 

8.

Covenants.

8.1          Use of Trademarks; Quality Control. For clarity, all goodwill
arising after the Effective Date in connection with the use of the Business
Trademarks shall inure solely to the benefit of Raptor. Additionally, Raptor
shall have the exclusive right to register, defend and enforce the Business
Trademarks and enter settlements for infringement thereof, including for past
infringements.

8.2          Right to Audit. Raptor shall for a period of three (3) years after
the calendar quarter to which the records pertain, maintain accurate and timely
records relating to (i) all milestone events described in Section 3 and (ii) the
royalties payable to BioMarin under this Agreement. All such records maintained
by Raptor shall be made available for inspection throughout such three (3) year
period by BioMarin (or its designated auditing or accounting professional or
employee reasonably acceptable to Raptor) for such purposes. Such inspections
may be made no more than once each calendar year during the normal business
hours of Raptor upon thirty (30) days advance notice, provided that if a
non-compliance is identified by an audit, then an additional audit may be
conducted during such calendar year. The auditor selected by BioMarin will be
obliged to execute a reasonable confidentiality agreement prior to commencing
any such inspection. In addition, Raptor may, at its expense, have a
representative or agent familiar with its record keeping systems be present at
the audit to assist BioMarin’s auditor in using such internal record management
system. BioMarin shall bear the costs and expenses of inspections conducted
under this Section 8.2.

8.3          Expenses and Taxes. All costs and expenses incurred in connection
with this Agreement and the transactions contemplated hereby shall be paid by
the Party incurring such expense.

8.4          Technology Transfer; Access. To the extent that any Transferred
Technology has not been delivered to Raptor prior to the Effective Date,
BioMarin agrees to provide Raptor and its representatives with reasonable access
to the Transferred Technology sufficient to enable Raptor to obtain the
Transferred Technology promptly following the Effective Date.

8.5          Further Assurances. BioMarin will execute and deliver all such
further and additional instruments, notices, releases, undertakings, consents,
certifications and agreements and other documents, and will do all such other
reasonable acts and things, as may be reasonably requested by Raptor to assure
to and vest in Raptor all the right, title and interest assigned to, or to be
assigned to, Raptor under this Agreement. Similarly, in the event of any
termination of this Agreement, Raptor will execute and deliver all such
instruments, notices, releases, undertakings, consents, certifications, and
agreements and other documents, and will do all such other reasonable acts and
things, as may be reasonably requested by BioMarin to

 

 

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acknowledge the assignment of the Transferred Technology to BioMarin to the
extent set forth in Section 11.3(b).

8.6          No Corporate Manipulation. Raptor agrees that it and its Affiliates
will not establish a corporate structure (i.e. ownership of capital stock) or
corporate relationship (i.e. ownership of capital stock) between Raptor, its
Affiliates or any third party in bad faith for the purpose of enabling Raptor,
its Affiliates or any third party to commercialize the Transferred Technology
without being obligated to make, or for the purpose of reducing in bad faith,
the payments to BioMarin required by this Agreement.

 

9.

Prosecution Enforcement.

 

9.1

Prosecution.

 

 

(a)

Raptor shall have the first right, but not the obligation, to prepare, file,
prosecute, and maintain Patents in the Transferred Technology and Raptor shall
have the exclusive right to control and make decisions with respect to such
activities, subject to BioMarin’s right under Section 9.1(b) to assume such
activities should Raptor desire to discontinue them. BioMarin agrees to use
commercially reasonable efforts to cooperate fully with Raptor in this regard.

 

(b)

If Raptor desires to discontinue prosecution of any Patent in the Transferred
Technology under Section 9.1, then it shall notify BioMarin at least sixty (60)
days (or such shorter period as is reasonably practicable for deadlines not
extendable beyond ninety (90) days) prior to the date the next action or filing
is due to be taken with respect to the applicable Patent. If requested by
BioMarin in writing within thirty (30) days after such notice, the Patent shall
be assigned to BioMarin, and the prosecution and maintenance of the applicable
Patent shall be transitioned to BioMarin, promptly; provided that Raptor hereby
retains a non-exclusive, worldwide, royalty free (except for the payments in
this Agreement, fully paid (except for the payments in this Agreement) right and
license, with the right to grant and authorize sublicenses, to make, have made,
use, sell, offer to sell, import, and otherwise exploit and commercialize all
products, components, services, and other subject matter under the Patent
assigned back to BioMarin. Notwithstanding the foregoing, BioMarin shall have no
right to assume the prosecution or maintenance, and Raptor shall not be required
to assign to BioMarin, any Patent claims that are not entitled to an effective
filing date of one of the Patents in the Transferred Technology prior to the
Effective Date (even if the claim is for an Improvement).

 

(c)

The prosecuting Party shall keep the other reasonably informed as to the status
of patent matters pertaining to the Transferred

 

 

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Technology, including providing to the other party copies of any significant
documents that such Party receives from or sends to patent offices, such as
notices of interferences, re-examinations, oppositions or requests for patent
term extensions, all as reasonably requested by the other Party.

 

(d)

The non-prosecuting Party shall, without demanding any further consideration
therefor, cooperate with the prosecuting Party and provide any assistance
requested by the prosecuting Party that is reasonably necessary, proper or
advisable to carry out or make effective the foregoing and the assignments in
this Agreement, including, without limitation, executing and filing
applications, registrations, powers of attorney and other appropriate documents
(including confirmatory assignments for Patents owned by Raptor), providing
appropriate consents and/or authorizations, and joining in any administrative or
judicial action relating to the prosecution or maintenance of any applications,
registrations or other rights within the Transferred Technology.

9.2          Enforcement. For clarity, the assignment to Raptor under this
Agreement includes the exclusive right, but not the obligation, for Raptor to
enforce and defend the Patents in the Transferred Technology. BioMarin shall
cooperate as reasonably requested by Raptor in such enforcement and defense,
including by taking such actions as necessary for satisfying the legal
requirements to file or maintain the action. Raptor shall retain all recoveries
for infringement of the Patents in the Transferred Technology, subject (after
reduction for costs and expenses of the litigation, attorneys and expert fees,
and the like, in each case that are not recovered by Raptor in the action) to
any payments to BioMarin required in this Agreement. In particular, after Raptor
deducts such costs and expenses of the litigation, attorneys and expert fees,
and the like, that are not recovered in the action, if Raptor recovered a
royalty, license fee, or other non-labeled damages for such infringement, such
royalty shall be considered Licensing Revenue on which a payment is due to
BioMarin, and if Raptor recovered its lost profits, such amounts shall be
considered Net Sales of Raptor on which a payment is due to BioMarin. Raptor’s
rights of enforcement under this Section 9.2 shall not apply with respect to any
Patents in the Transferred Technology to the extent they have been assigned back
to BioMarin.

 

10.

Indemnification.

 

 

10.1

Indemnification.

 

(a)

Raptor agrees to indemnify and hold BioMarin and its respective directors,
officers, employees, agents and affiliates, (the “BioMarin Indemnified
Parties”), harmless against all claims, losses, liabilities, damages,
deficiencies, costs and expenses, including reasonable attorneys’ fees and
expenses of investigation and defense and diminution in value (hereinafter
individually a “Loss” and collectively “Losses”) incurred or sustained by any of
BioMarin Indemnified Parties, directly or indirectly, as a result of

 

 

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any breach or inaccuracy of a representation or warranty of Raptor contained in
this Agreement.

 

(b)

BioMarin agrees to indemnify and hold Raptor and its respective directors,
officers, employees, agents and affiliates, (the “Raptor Indemnified Parties”),
harmless against all Losses incurred or sustained by any of Raptor Indemnified
Parties, directly or indirectly, as a result of (i) any breach or inaccuracy of
a representation or warranty of BioMarin contained in this Agreement.

10.2       Indemnification Deductible. Notwithstanding any provision of this
Agreement to the contrary, neither Raptor Indemnified Parties nor BioMarin
Indemnified Parties may recover any Losses from an indemnifying Party under
Section 10.1 unless and until one or more such Losses exceed $50,000 in the
aggregate (the “Deductible Amount”) and provided further that such Raptor
Indemnified Party or BioMarin Indemnified Party, as the case may be, shall not
be entitled to indemnification for the Deductible Amount.

10.3       Procedure. A Party that intends to claim indemnification under this
Article 10 (the “Indemnitee”) shall promptly notify the other Party (the
“Indemnitor”) in writing of any Losses in respect of which the Indemnitee
intends to claim such indemnification, and the Indemnitor shall have sole
control of the defense and settlement thereof. The indemnity arrangement in this
Article 10 shall not apply to amounts paid in settlement of any action with
respect to a Loss, if such settlement is effected without the consent of the
Indemnitor, which consent shall not be withheld unreasonably. The failure to
deliver written notice to the Indemnitor within a reasonable time after the
commencement of any claim or action with respect to a Loss, if prejudicial to
its ability to defend such action, shall relieve such Indemnitor of any
liability to the Indemnitee under this Article 10 but the omission so to deliver
written notice to the Indemnitor shall not relieve the Indemnitor of any
liability that it may have to any Indemnitee otherwise than under this
Article 10. The Indemnitee under this Article 10 shall cooperate fully with the
Indemnitor and its legal representatives in the investigation of any action with
respect to a Claim covered by this indemnification, at the Indemnitor’s expense.
Notwithstanding the foregoing, the Indemnitor shall not be responsible for any
costs or expenses incurred without the prior written consent of the Indemnitor.

10.4       Limitation of Liability. The provisions of this Article 10 shall be
the sole and exclusive remedy of (i) Raptor or any Raptor Indemnified Party (and
corresponding liability of Raptor) and (ii) BioMarin or any BioMarin Indemnified
Party (and corresponding liability to Raptor) for any damage, claim, cause of
action or right of any nature arising out of or relating to any breach of its
representations and warranties in Sections 5 and 6 of this Agreement. The
maximum amount BioMarin Indemnified Parties may recover from Raptor pursuant to
the indemnity set forth in Section 10.1 for Losses shall be limited to,
$1,000,000. The maximum amount Raptor Indemnified Parties may recover from
BioMarin pursuant to the indemnity set forth in Section 10.1 for Losses shall be
limited to $1,000,000. Notwithstanding the foregoing, nothing in this Agreement
will be deemed to limit any right or remedy for fraud or for willful breaches of
any representation, warranty or covenant set forth in this Agreement or any
certificate or instrument delivered pursuant to this Agreement.

 

 

 

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11.

Termination.

11.1       Term. This Agreement shall become effective as of the Effective Date
and shall continue in full force and effect until the later of (i) the
expiration of the last claim under the Patents in the Transferred Technology or
(ii) twenty (20) years after the Effective Date, unless terminated in accordance
with the terms of this Article 11 below (such period, the “Term”).

 

11.2

Rights of Termination.

 

(a)

By Raptor. Raptor may terminate this Agreement at any time by giving at least
ninety (90) days prior written notice.

 

(b)

By BioMarin.

 

 

i.

The right, title and interest in and to the Transferred Technology that has been
assigned to Raptor under this Agreement shall be assigned by Raptor back to
BioMarin if (i) on or before the six month anniversary of the Effective Date,
Raptor has not received total aggregate debt or equity financing of at least two
million five hundred thousand dollars ($2,500,000) or (ii) Raptor (a) files in
any court pursuant to any statute, a petition in bankruptcy or for
reorganization in bankruptcy or for an equivalent arrangement or equivalent
appointment of a receiver or trustee of all or substantially all of its business
or assets; (b) is served with an involuntary petition against it, filed in any
bankruptcy proceeding, and in the case of each of (a) and (b), such petition has
not been dismissed within ninety (90) days after the filing thereof.

 

ii.

BioMarin shall have the right to terminate this Agreement in the event that
Raptor materially breaches its obligations to make payments to BioMarin and such
breach is not remedied within a period of ninety (90) days after Raptor receives
notice of the breach from BioMarin or ninety (90) days after resolution against
Raptor of a dispute regarding payment as contemplated in Section iii below.

 

iii.

Notwithstanding anything to the contrary, in the event of any dispute in
connection with any termination or notice of termination under this Section
11.2(b) or any obligation to assign Transferred Technology back to BioMarin, the
Agreement shall not be considered terminated, an Raptor shall not be required to
assign the Transferred Technology back to BioMarin, unless the dispute is
resolved against Raptor, and in the case of a termination under Section
11.2(b)(ii) Raptor does not make the payment within thirty (30) days after
resolution of the dispute against Raptor.

 

 

 

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11.3

Effect of Termination.

 

(a)

Unless this Agreement is previously terminated pursuant to Section 11.2, upon
expiration of the Term, all payment obligations under Articles 3 and 4 hereunder
shall terminate and have no further force or effect; provided that all
obligations accruing prior to the expiration of the Term have been satisfied.

 

(b)

Upon any termination of this Agreement under Section 11.2, Raptor shall assign
back to BioMarin all of Raptor’s right, title and interest in and to the
Transferred Technology and any assignment back to BioMarin shall not occur until
resolution of any dispute as contemplated in Section 11.2(b)(iii) above.

 

(c)

Upon assignment of the Transferred Technology back to BioMarin, Raptor shall
have no further right to use or exploit the Patents, Copyrights, or Trademarks
in the Transferred Technology to the extent assigned to BioMarin, but Raptor
shall retain a worldwide, non-exclusive, fully paid, royalty free, perpetual,
non-terminable right and license, with the right to grant and authorize
sublicenses, under all other Intellectual Property in the Transferred Technology
to make, have made, use, sell, offer to sell, import, disclose, reproduce,
produce derivatives of, distribute, transmit, publicly perform and display, and
otherwise exploit any and all products, components, services and other subject
matter, provided that, with respect to amounts that have become due and payable
to BioMarin hereunder prior to such termination, Raptor pays such amounts to
BioMarin. Notwithstanding the foregoing, in the event that Raptor obtains
BioMarin’s prior written consent, such consent not to be unreasonably withheld,
to a license of the Transferred Technology, as part of such consent, BioMarin
will agree that, in the event of an assignment of the Transferred Technology
back to BioMarin pursuant this Section 11, conditioned on the Licensee paying
BioMarin the amounts that would otherwise be due to it under this Agreement,
following such assignment and continuing for as long as the Licensee continues
to make such payments, BioMarin will automatically, without further action or
the requirement for further payments, grant a license to the Transferred
Technology to the Licensee with the same scope and rights as the license between
Raptor and the Licensee.

 

(d)

Accrued Rights. Expiration or termination of this Agreement shall not affect the
Parties’ liability that has accrued as of the expiration or termination date,
including with respect to royalties or Milestone Fees hereunder that have
accrued prior to the effectiveness of the expiration or termination. Any right
to terminate this Agreement shall be in addition to and not in lieu of

 

 

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all other rights or remedies that the Party giving notice of termination may
have at law, in equity or otherwise.

 

(e)

Survival. In the event of any termination or expiration of this Agreement,
Articles and Sections 2.4, 2.5, 7, 8.1, 8.2, 8.3, 10, 11.3, and 12 shall
survive. Additionally, in the event of any expiration of this Agreement,
Articles and Sections 2.1, 2.2, 2.3, 7, 8.4, 8.5, and 9 shall also survive.
Except as set forth in this Section 11.3 above, all terms and conditions of this
Agreement shall terminate upon any expiration or termination of this Agreement.

 

12.

General.

12.1       Amendments; Waivers. This Agreement and any Schedule or Exhibit may
be amended only by an agreement in writing signed by both Parties. No waiver of
any provision nor consent to any exception to the terms of this Agreement or any
agreement contemplated hereby shall be effective unless in writing and signed by
the Party to be bound and then only to the specific purpose, extent and instance
so provided.

12.2       Entire Agreement. This Agreement, and that certain “Security
Agreement” entered into between the Parties on even date herewith, constitutes
and contains the entire agreement and final understanding between the Parties
concerning the Transactions and all other subject matters addressed herein or
pertaining thereto. This Agreement, and such “Security Agreement”,” are intended
by the Parties as a final expression of their agreement with respect to such
terms as are included herein and therein and, further, are intended by the
Parties as a complete and exclusive statement of the terms of their agreement.
This Agreement, and such “Security Agreement”,” supersede and replace all prior
negotiations and all prior or contemporaneous representations, promises or
agreements, proposed or otherwise, whether written or oral, concerning all
subject matters addressed herein or pertaining hereto. Any representation,
promise or agreement not specifically included in this Agreement, or such
“Security Agreement” shall not be binding upon or enforceable against any Party
to this Agreement. This is a fully integrated agreement.

 

12.3

Dispute Resolution and Governing Law.

 

(a)

Escalation. Raptor and BioMarin will attempt in good faith to resolve
expeditiously any dispute, claim or controversy arising out of or relating to
this Agreement (the “Dispute”) promptly by negotiations between executives who
have authority to settle the controversy. Either Party may give the other Party
written notice (the “Escalation Notice”) of any Dispute that has not been
resolved. Within 15 days after delivery of the Escalation Notice, the receiving
Party shall submit to the other a written response. The Escalation Notice and
the response thereto shall include (a) a statement of each Party’s position and
a summary of arguments supporting that position, and (b) the name and title of
the executive

 

 

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who will represent that Party and of any other person who will accompany the
executive. Within 30 days after delivery of the Escalation Notice, the
executives of both Parties shall meet at a mutually acceptable time and place,
and thereafter as often as they reasonably deem necessary, to attempt to resolve
the Dispute. All negotiations pursuant to this clause including the Escalation
Notice and the information contained therein are confidential and shall be
treated as compromise and settlement negotiations for purposes of applicable
rules of evidence. The Parties shall attempt to resolve any Dispute pursuant to
the procedure set forth in this Section 12.3(a) for a period up to 60 days from
the date of delivery of the Escalation Notice before resorting to other
available remedies.

 

(b)

Arbitration. Any Dispute which has not been resolved by the specified
non-binding procedure set forth in Section 12.3(a) within 60 days of the date of
delivery of the Escalation Notice shall be settled by binding arbitration in
accordance with the CPR Non-Administered Arbitration Rules in effect on the date
of this Agreement, by three independent and impartial arbitrators, none of whom
shall be appointed by either Party, provided that claims for less than $200,000
shall be settled by one independent and impartial arbitrator. The arbitration
shall be governed by the United States Arbitration Act, 9 U.S.C. §§ 1-16, as the
same may be amended from time to time, and judgment upon the award rendered by
the arbitrators may be entered by any court having jurisdiction thereof. The
place of the arbitration shall be San Francisco, California. The arbitrators
shall award damages equal to actual and compensatory damages, and shall award
attorneys’ fees to the prevailing Party. The arbitrators are not empowered to
award consequential, special, incidental, exemplary or punitive damages.

 

(c)

Injunctive Relief. Nothing contained in this Section 12.3 shall prevent either
Party from resorting to judicial process if injunctive or other equitable relief
from a court is necessary to prevent serious and irreparable injury to one Party
or to others. The use of arbitration procedures will not be construed under the
doctrine of laches, waiver or estoppel to affect adversely either Party’s right
to assert any claim or defense.

 

(d)

Governing Law. This Agreement shall be governed by, interpreted under, and
construed in accordance with the internal laws of the State of California
applicable to contracts made and performed in such State and without regard to
conflicts of law doctrines, except to the extent that certain matters are
preempted by Federal law.

 

 

 

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(e)

Jurisdiction and Consent to Service. Parties seeking injunctive relief pursuant
to Section 12.3(c) or enforcement of Section 12.3(b) shall do so in accordance
with the laws of the State of California, and without limiting the jurisdiction
or venue of any other court, the Parties (a) agree that any suit, action or
proceeding arising out of or relating to this Agreement shall be brought in the
state or federal courts of California; (b) consent to the exclusive jurisdiction
of each such court in any suit, action or proceeding relating to or arising out
of this Agreement; (c) waive any objection which any of them may have to the
laying of venue in any such suit, action or proceeding in any such court; and
(d) agree that service of any court paper in any such suit, action or proceeding
may be made in any manner as may be provided under the applicable laws or court
rules governing service of process in such court.

 

(f)

Attorneys’ Fees. In any dispute arising between the Parties, the prevailing
Party shall be paid by the non-prevailing Party all reasonable attorneys’ fees
and costs incurred by the prevailing Party in connection with such dispute.

12.4       Headings. The descriptive headings of the Articles, Sections and
Subsections of this Agreement are for convenience only and do not constitute a
part of this Agreement.

12.5       Counterparts. This Agreement and any amendment hereto or any other
agreement (or document) delivered pursuant hereto may be executed in one or more
counterparts (and may be exchanged via fax) and by different Parties in separate
counterparts. All of such counterparts shall constitute one and the same
agreement (or other document) and shall become effective (unless otherwise
therein provided) when one or more counterparts have been signed by each Party
and delivered to the other Parties.

12.6       Publicity and Reports. Neither Party shall issue any press release,
publicity statement or other public notice relating to this Agreement, or the
Transactions, without the prior written approval of the other Party (such
approval not to be unreasonably withheld or delayed), except to the extent that
a particular action may be required by applicable law, in which event the Party
taking the particular action will give reasonable notice to the other Parties
and will consult with such other Parties regarding such action.

12.7       Parties in Interest. This Agreement will be binding upon and inure to
the benefit of each Party, and nothing in this Agreement, express or implied,
shall confer upon any other person any rights or remedies of any nature
whatsoever under or by reason of this Agreement.

 

 

 

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12.8       Relationship. The relationship of Raptor and BioMarin established by
this Agreement is of independent contractors and not agents, and nothing in this
Agreement shall be construed:

 

(a)

To give either Party the power to direct or control the daily activities of the
other Party beyond the obligations imposed on Raptor and BioMarin, respectively,
by this Agreement;

 

(b)

To constitute the Parties as partners, joint ventures, fiduciaries, co owners or
otherwise as participants in joint undertaking; or

 

(c)

To allow either Party to create or assume any obligation on behalf of the other
Party for any purpose whatsoever.

12.9       Notices. All notices, demands, requests, consents, approvals or other
communications required or permitted to be given hereunder or which are given
with respect to this Agreement shall be in writing and shall be delivered
(charges prepaid, receipt confirmed or return receipt requested (if available))
by hand, by nationally recognized courier service, by certified mail or
facsimile, addressed as set forth below or to such other address as such Party
shall have specified most recently by written notice. Notice shall be deemed
given and effective (i) if delivered by hand or by nationally recognized courier
service, when delivered at the address specified in this Section 12.9 (or in
accordance with the latest unrevoked written direction from such Party), (ii) if
by certified mail, upon mailing or (iii) if given by facsimile when such
facsimile is transmitted to the fax number specified in this Section 12.9 (or in
accordance with the latest unrevoked written direction from such Party),
provided the appropriate confirmation is received.

 

To BioMarin:

BioMarin Pharmaceutical Inc.

105 Digital Drive

Novato, CA 94949

Attention: G. Eric Davis

Fax: (415) 382-7889

 

To Raptor:

Raptor Pharmaceutical, Inc.

PO Box 226

Sonoma, CA 95476

Attention: Christopher M. Starr, Ph.D.

Fax: 707-939-1143

with a copy (which shall not constitute notice) to:

Wilson Sonsini Goodrich & Rosati

650 Page Mill Road

Palo Alto, CA 94304

Attention: Kenneth A. Clark

Fax: 650-493-6811

 

 

 

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12.10     Expenses. Each Party shall each pay its own expenses incident to the
negotiation, preparation and performance of this Agreement and the transactions
contemplated hereby, including, but not limited to, the fees, expenses and
disbursements of its respective investment bankers, accountants and counsel.

12.11     No Assignment. This Agreement may not be assigned by either of the
Parties hereto without the prior written consent of the other Party hereto,
provided, however, either Party may assign this Agreement and all rights, duties
or obligations hereunder to its affiliates or in connection with a sale of more
than 50% of the outstanding capital stock or equity interests of such Party, in
one or more transactions, a merger, by operation of the law, or the sale or
other transfer of all or substantially all of the assets to which this Agreement
relates. Any attempted assignment or delegation of rights, duties or obligations
hereunder in contravention hereof shall be void and of no effect. For clarity,
nothing in this Section 12.11 shall be construed to limit the rights or licenses
of Raptor, including the rights to grant and authorize licenses, in this
Agreement, and Raptor shall not be required to obtain any consent to grant or
authorize any license. Nothing in this Section shall limit BioMarin’s rights
under Section 8.6.

12.12     Remedies; Waiver. Except as otherwise set forth in this Agreement, all
rights and remedies existing under this Agreement are cumulative to, and not
exclusive of, any rights or remedies otherwise available under applicable law.
No failure on the part of any party to exercise or delay in exercising any right
hereunder shall be deemed a waiver thereof, nor shall any single or partial
exercise preclude any further or other exercise of such or any other right.

12.13     Knowledge Convention. Whenever any statement herein or in any
schedule, exhibit, certificate or other document delivered to any Party pursuant
to this Agreement is made by any Party or its representative “to its knowledge,”
shall mean the actual knowledge of the officers of each Party directly
associated with this Agreement and the Transactions without any investigation;
provided that, as to BioMarin, knowledge does not include the knowledge of
Dr. Christopher Starr.

 

12.14

Confidentiality.

 

(a)

All information disclosed by any Party (or its representatives) to the other
Party (or its representatives) in connection with this Agreement shall be kept
confidential by such other Party and its representatives and shall not be used
by any such persons other than as contemplated by this Agreement, except to the
extent that such information (i) was known by the recipient when received,
(ii) is or hereafter becomes lawfully obtainable from other sources, (iii) is
necessary or appropriate to disclose to a governmental entity having
jurisdiction over the Parties, (iv) as may otherwise be required by law, or
(v) to the extent such duty as to confidentiality is waived in writing by the
other Party. Notwithstanding anything to the contrary, the Trade Secrets and
confidential information that is included in the Transferred Technology shall be
considered the Confidential Information of Raptor and not BioMarin, except to
the extent such Trade Secrets and confidential information have

 

 

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been assigned back to BioMarin. Notwithstanding anything to the contrary, the
Transferred Know-How includes all ideas, concepts and information that are
necessary to the Business and are retained in the memories of individuals that
were previously employed by BioMarin in connection with the Business and that
commence employment or other work with Raptor within six (6) months after the
Effective Date; provided that in the event of any assignment back to BioMarin,
such ideas, concepts and information shall be licensed to Raptor to the extent
set forth in Section 11.3 above. BioMarin agrees that it shall not make any
assertion or claim against any such individuals as a result of the use,
disclosure, or other exploitation of such ideas, concepts and information,
whether based upon any of their agreements with BioMarin or otherwise. The
Parties agree that such individuals are third party beneficiaries, with the
power to enforce, this Section.

 

(b)

Confidentiality of Agreement. Notwithstanding anything to the contrary, each
Party may disclose the terms and conditions of this Agreement without consent
(i) to advisors, investors and others on a need-to-know basis under conditions
which reasonably ensure the confidentiality thereof, (ii) as required by any
court or other governmental body; (iii) as otherwise required by law; (iv) in
confidence to legal counsel of such parties; (v) in confidence, in connection
with the enforcement of this Agreement or rights under this Agreement; (vi) in
confidence, in connection with a merger, acquisition of stock or assets,
proposed merger or acquisition, or the like; or (vii) as advisable or required
in connection with any government or regulatory filings, including without
limitation filings with the SEC.

12.15     Representation By Counsel; Interpretation. BioMarin and Raptor each
acknowledge that each Party to this Agreement has been represented by counsel in
connection with this Agreement and the transactions contemplated by this
Agreement. Accordingly, any rule of Law, or any legal decision that would
require interpretation of any claimed ambiguities in this Agreement against the
Party that drafted it has no application and is expressly waived. The provisions
of this Agreement shall be interpreted in a reasonable manner to effect the
intent of Raptor and BioMarin.

12.16     Severability. If any provision of this Agreement is determined to be
invalid, illegal or unenforceable by any court or governmental entity, the
remaining provisions of this Agreement shall remain in full force and effect. In
the event of any such determination, the Parties agree to negotiate in good
faith to modify this Agreement to fulfill as closely as possible the original
intents and purposes hereof. To the extent permitted by law, the Parties hereby
to the same extent waive any provision of law that renders any provision hereof
prohibited or unenforceable in any respect.

 

 

 

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IN WITNESS WHEREOF, each of the Parties hereto has caused this Agreement to be
executed by a duly authorized officer as of the day and year first above
written.

RAPTOR PHARMACEUTICAL INC.

By:

                                                                   

 

Name: Christopher Starr

 

 

Title: CEO

 

BIOMARIN PHARMACEUTICAL INC.

By:

                                                                   

 

Name: G. Eric Davis

 

 

Title: Vice President, Corporate Counsel

 

 

 

 

 

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