Exhibit 10.1

TERMINATION OF SPLIT DOLLAR AGREEMENT

     THIS TERMINATION OF SPLIT DOLLAR AGREEMENT, entered into this 31st day of
July, 2008, by and among Enzo Biochem, Inc., a New York corporation (hereinafter
the “Company”), Shahram K. Rabbani, an individual residing in the State of New
York (hereinafter referred to as the “Employee”), and Diana Rabbani, Robert H.
Cohen and Jeremy Haskel Rabbani, as trustees of the Shahram K. Rabbani
Irrevocable Insurance Trust, under trust agreement dated October 22, 1998
(hereinafter the “Owner”).

     WITNESSETH THAT:

     WHEREAS, the Employee is employed by the Company; and

     WHEREAS, the Owner is the owner of a policy or policies of life insurance
insuring the life of Employee (hereinafter referred to individually as a
“Policy” and collectively as the “Policies”)

     WHEREAS, as of October 22, 1998, the Company and Owner entered into a Split
Dollar Agreement (hereinafter referred to as the “SDA”) whereby Company agreed
to pay a portion of the premiums due under the Policies; and

     WHEREAS, the Company had the Policies collaterally assigned to it by the
Owner in order to secure the repayment of amounts that the Company paid toward
the premiums on the Policies; and

     WHEREAS, the Owner retained all other ownership rights in the Policies; and

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     WHEREAS, on June 30, 2008, pursuant to Article IX of the SDA, the Owner
provided notice to the Company of its intent to terminate the SDA as to all
Policies currently owned by the Owner; and

     WHEREAS, the Owner has agreed to pay the Company Two Hundred Ninety-Eight
Thousand Three Dollars and Sixty-Six Cents ($298,003.66), no later than July 31,
2008, as reimbursement for the premiums paid by the Company on the Policies; and

     WHEREAS, in anticipation of the Owner’s reimbursement of the premiums on
the Policies paid by the Company, the Company has released all of its rights
under the collateral assignment of the Policies;

     NOW THEREFORE, in consideration of the reimbursement of the Policy
premiums, the release of the collateral assignment and the mutual promises
contained herein, the parties hereto agree as follows:

     1.      Ownership of Policies.

              The Owner shall be the sole and absolute owner of the Policies,
and may exercise all ownership rights granted to the owner thereof by the terms
of the Policies.

     2.      Reimbursement of Premiums Advanced by Company.

              On this same day, the Owner has agreed to pay the Company Two
Hundred Ninety-Eight Thousand Three Dollars and Sixty-Six Cents ($298,003.66),
no later than July 31, 2008, as reimbursement to the Company in full
satisfaction of all premiums paid by the Company on the Policies.

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     3.      Release of Collateral Assignment.

              The Company executed on this same day a Release of Collateral
Assignment that confirmed that the liabilities for which the Policies were
assigned and held as collateral security were fully satisfied this same day. The
Company released all interests in the Policies to the Owner.

     4.      Collection of Death Proceeds.

              (a)      Upon the death of the Employee, the beneficiary or
beneficiaries designated by the Owner shall collect the death benefits provided
under the Policies.

              (b)      Upon the death of the Employee, the Company shall have no
right whatsoever to receive any portion of the death benefit payable under any
Policy. The entire death benefit provided under each Policy, if any, shall be
paid directly to the beneficiary or beneficiaries designated by the Owner, in
the manner and in the amount or amounts provided in the beneficiary designation
provision of each Policy.

     5.      Insurer Not a Party. The Insurer shall be fully discharged from its
obligations under the Policies by payment of the death benefits under the
Policies to the beneficiary or beneficiaries named in the Policies, subject to
the terms and conditions of the Policies. In no event shall the Insurer be
considered a party to this Agreement, or any modifications or amendments hereof.
No provision of this Agreement, nor of any modifications or amendments hereof,
shall in any way be construed as enlarging, changing, varying, or in any other
way affecting the obligations of the Insurer as expressly provided in the
Policies, except insofar as the provisions hereof are made a part of the
Policies by the prior-executed Collateral Assignments

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which now have been released on this same day, and will be filed with the
Insurer in connection herewith.

     6.      Amendment. This Termination Agreement may not be amended, altered
or modified, except by a written instrument signed by the parties hereto, or
their respective successors or assigns.

     7.      Binding Effect. This Agreement shall be binding upon and inure to
the benefit of the Company and its successors and assigns (including, without
limitation, the surviving entity as a result of a merger or other acquisition of
the Company), and the Employee, his successors, assigns, heirs, executors,
administrators and beneficiaries.

     8.     Notices. Any notice, consent or demand required or permitted to be
given under the provisions of this Agreement shall be in writing, and shall be
signed by the party giving or making the same. If such notice, consent or demand
is mailed to a party hereto, it shall be sent by United States certified mail,
postage prepaid, addressed to such party’s last known address as shown on the
records of the Company. The date of such mailing shall be deemed the date of
notice, consent or demand.

     9.     Arbitration. All claims, disputes or other matters in question
arising out of this Agreement shall be determined by arbitration which, unless
the parties mutually agree otherwise, shall be determined by and in accordance
with the Commercial Rules of the American Arbitration Association.

     10.     Governing Law. This Agreement, and the rights of the parties
hereunder, shall be governed by and construed in accordance with the laws of New
York.

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     IN WITNESS WHEREOF, the parties hereto have executed this Agreement, in
duplicate, as of the day and year first above written.

    COMPANY  -   ATTEST:    ENZO BIOCHEM, INC.        /s/   By: /s/ Barry W.
Weiner         Barry W. Weiner, President    _______________,
______________________       Title           EMPLOYEE      WITNESS:             
      /s/   /s/ Shahram K. Rabbani       Shahram K. Rabbani            OWNER    
WITNESS:    Diana Rabbani, Trustee of the        Shahram K. Rabbani 1998
Irrevocable Insurance        Trust (u/t/a dated 10/22/98)              /s/   /s/
Diana Rabbani        Diana Rabbani        WITNESS:    Robert H. Cohen, Trustee
of the        Shahram K. Rabbani 1998 Irrevocable Insurance        Trust (u/t/a
dated 10/22/98)            /s/   /s/ Robert H. Cohen        Robert H. Cohen     
  WITNESS:    Jeremy Haskel Rabbani, Trustee of the        Shahram K. Rabbani
1998 Irrevocable Insurance        Trust (u/t/a dated 10/22/98)              /s/
  /s/ Jeremy Haskel Rabbani        Jeremy Haskel Rabbani   

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