Exhibit 10.47

Amendment to License Agreement

This will amend the license agreement between Micro Therapeutics, Inc. (“MTI”)
and Biocoat, Inc. (“Biocoat”) of December 9, 1999 (the “Agreement” and this
“Amendment”).

The effective date of this Amendment is January 1, 2005.

Schedule A of the Agreement, listing the Products, is hereby replaced with the
attached Schedule A, dated November 4, 2004.

MTI hereby represents that it intends to use the hydrophilic coatings technology
licensed from Biocoat for the Products listed in the attached Schedule A for the
remaining term of the Agreement.

In consideration of this representation of MTI, Biocoat agrees to replace the
Royalty Rate
Schedule of the Agreement, Schedule D, with the attached Schedule D, dated
November
4, 2004.

Both parties to the Agreement hereby signify their approval of this Amendment.

/s/Djoerd Hoekstra, President

 

/s/William H. Dippel

 

 

Djoerd Hoekstra, President

 

William H. Dippel, V.P. Operations

 

 

Biocoat, Inc.

 

Micro Therapeutics, Inc.

 

 

Date:

12/09/04

 

 

Date:

12/10/04

 

 

 

 

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SCHEDULE A

PRODUCTS

 

 

Model #

 

Description

 

 

 

 

 

HYPERFORM

 

104-4470

 

HYPERFORM 4.0 X 7 MM SYS

HYPERFORM

 

104-4770

 

HYPERFORM 7.0 X 7 MM SYS

HYPERGLIDE

 

104-41 08

 

HYPERGLIDE 15 MM ST BALL

HYPERGLIDE

 

104-4112

 

HYPERGLIDE 4.0 X 15 MM,

HYPERGLIDE

 

104-4113

 

HYPERGLIDE 4.0X10 MM

HYPERGLIDE

 

104-4120

 

HYPERGLIDE, 10 MM ST BAL

HYPERGLIDE

 

104-4127

 

HYPERGLIDE 4.0 X 20 MM,

HYPERGLJDE

 

104-4130

 

HYPERGLIDE 20MM ST BALL

HYPERGLIDE

 

104-4131

 

HYPERGLIDE 30 MM ST BALL

HYPERGLIDE

 

104-4132

 

HYPERGLIDE SYSTEM- 30MM

ULTRAFLOW

 

105-5065

 

ULTRAFLOW HPC 1 .5F FLOW

ULTRAFLOW

 

105-5066

 

ULTRAFLOW EXTENDED

REBAR IR (FG)

 

105-5081-110

 

REBAR-18, 110CM, MICRO C

REBAR IR (FG)

 

105-5081-130

 

REBAR-18, 130CM, MICRO C

REBAR IR (FG)

 

105-5081-153

 

REBAR-18, 153CM, M1CRO C

REBAR IR (FG)

 

105-5082-110

 

REBAR-027, 110CM MICRO

REBAR IR (FG)

 

105-5082-130

 

REBAR-027, 130CM, MICRO

REBAR IR (FG)

 

105-5082-145

 

REBAR-027, 145CM, MICRO

REBAR INR (FG)

 

105-5078-153

 

REBAR-l0, 153 CM, MICRO

REBAR INR (FG)

 

105-5078-153C

 

REBAR-l0, 153 CM, MICRO

REBAR INR (FG)

 

105-5078-1 70

 

REBAR-l0, 170 CM, MICRO

REBAR INR (FG)

 

105-5078-170C

 

REBAR-l0, 170 CM, MICRO

REBAR INR (FG)

 

105-5080-143

 

REBAR-14, 143CM, MICRO C

REBAR INR (FG)

 

105-5080-143C

 

REBAR-14, 143CM, MICRO C

REBAR INR (FG)

 

105-5080-153

 

REBAR-14, 153CM, MICRO C

REBAR INR (FG)

 

105-5080-153C

 

REBAR-14, 153CM, MICRO C

REBAR INR (FG)

 

105-5080-1 70

 

REBAR-14, 170CM MICRO CA

REBAR INR (FG)

 

105-5080-170C

 

REBAR-14, 170CM MICRO

REBAR INR (FG)

 

105-5083-153

 

REBAR-18, 153 MICRO CATH

REBAR INR (FG)

 

105-5084-110

 

REBAR-18, SOFT TIP, 110

REBAR INR (FG)

 

105-5084-130

 

REBAR-18, SOFT TIP, 130

REBAR INR (FG)

 

105-5084-143

 

REBAR-18, SOFT TIP, 143

REBAR INR (FG)

 

105-5084-153

 

REBAR-18, SOFT TIP, 153

REBAR INR (FG)

 

105-5085-143

 

REBAR-18, SOFT TIP, 143

REBAR INR (FG)

 

105-5085-153

 

REBAR-18, SOFT TIP, 153

ECHELON

 

105-5091-1 50

 

ECHELON 10 MICRO

ECHELON

 

105-5092-1 50

 

ECHELON 14 MICRO

ECHELON

 

145-5091-1 50

 

ECHELON 10, 45 DEGREE

ECHELON

 

190-5091-1 50

 

ECHELON 10, 90 DEGREE

ECHELON

 

145-8092-1 50

 

ECHELON 14, 45 DEGREE

ECHELON

 

190-5092-150

 

ECHELON 14, 90 DEGREE

NAUTICA (FG)

 

105-5094-153

 

NAUTICA MICROCATHETER

MARATHON

 

105-5055

 

MARATHON MICROCATHETER

 

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SCHEDULE D

ROYALTY RATE SCHEDULE

ROYALTY RATE – Effective January 1, 2005

a.                                     For net sales up to $10 million U.S.
dollars in a given calendar year, the rate will be 1.5%

b.                                    For net sales in excess of$10 million U.S
dollars and up to $50 million U.S dollars in a calendar year, the rate will be
1%.

c.                                     For net sales in excess of $50 million
U.S dollars in a given calendar year, the rate will be .5%.

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