EXHIBIT 10.15

THIRD AMENDMENT TO
AMENDED AND RESTATED REPLACEMENT LOAN AGREEMENT

     THIS THIRD AMENDMENT TO AMENDED AND RESTATED REPLACEMENT LOAN AGREEMENT
(the “Agreement”) is made this 11th day of June, 2001, but effective as of the
31st day of May 2001, by and among BIORELIANCE CORPORATION, a corporation
organized and in good standing under the laws of the State of Delaware,
successor in interest to Microbiological Associates, Inc. (the “Company”),
BIORELIANCE TESTING AND DEVELOPMENT, INC., formerly known as MA BioServices,
Inc., a corporation organized and in good standing under the laws of the State
of Delaware (“MA BioServices”), BIORELIANCE MANUFACTURING, INC., formerly known
as Magenta Corporation, a corporation organized and in good standing under the
laws of the State of Delaware (“Magenta”) and MAGENTA VIRAL PRODUCTION, INC., a
corporation organized and in good standing under the laws of the State of
Delaware (“Magenta Viral”; together with the Company, MA BioServices and
Magenta, each a “Borrower” and collectively, the “Borrowers”) and BANK OF
AMERICA, N.A., successor in interest to NATIONSBANK, N.A., each a national
banking association, its successors and assigns, (the “Lender”).

RECITALS

     A.     The Lender has made certain loans to the Borrowers, as more fully
described in that certain Amended and Restated Replacement Loan Agreement by and
among the Borrowers and the Lender dated as of October 31, 1997 (as amended from
time to time, the “Restated Loan Agreement”).

     B.     The Borrowers have requested and the Lender has agreed to extend the
maturity of Loan No. 3 upon the terms and subject to the conditions hereinafter
set forth.

     C.     All capitalized terms used herein and not otherwise defined herein
shall have the meanings given to such terms in the Restated Loan Agreement.

AGREEMENTS

     NOW, THEREFORE, in consideration of the premises, the mutual agreements
herein contained, and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the Borrowers and the Lender
hereby agree as follows:

     1.      Recitals. The above Recitals are true and correct in all material
respects and that the same are incorporated herein and made a part hereof by
reference.

     2.     Line of Credit Replacement Note. From and after the effective date
hereof, all references in the Restated Loan Agreement and the Loan Documents to
Loan No. 3 and/or the Line of Credit Replacement Note shall be deemed to refer
to that certain line of credit in the

 

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current maximum principal amount of Two Million Dollars ($2,000,000) as
evidenced by that certain Fifth Replacement Revolving Promissory Note of even
date herewith in the maximum principal amount of Two Million Dollars
($2,000,000).

     3.     Conditions Precedent. This Agreement shall become effective on the
date the Lender receives the following, each of which shall be satisfactory in
form and substance to the Lender:

          (a)  A Fifth Replacement Revolving Promissory Note issued and
delivered by the Borrowers in the form of EXHIBIT B attached hereto and
incorporated herein by reference, payable to the order of the Lender in the
maximum principal amount of Two Million and No/100 Dollars ($2,000,000.00)
(which Fifth Replacement Revolving Promissory Note is sometimes referred to
herein as the “Restated Note”);

          (b)  Proof that the Borrowers have paid all costs and expenses to the
Lender and its counsel in connection with this Agreement, including but not
limited to the Lender’s reasonable attorneys fees invoiced as of such date; and

          (c)  Such other information, instruments, opinions, documents,
certificates and reports as the Lender may in its reasonable discretion deem
necessary.

     4.     Restated Note.  EXHIBIT B to the Restated Loan Agreement is being
replaced in its entirety with EXHIBIT B attached hereto. The Borrowers shall
execute and deliver to the Lender on the date hereof the Restated Note in
substitution for and not satisfaction of, the issued and outstanding Line of
Credit Replacement Note, and the Restated Note shall be the “Line of Credit
Replacement Note” for all purposes of the Loan Documents. The Note being
substituted pursuant to this Agreement shall be marked “Replaced” and returned
to the Company after the execution and delivery of the Restated Line of Credit
Replacement Note to the Lender.

     5.     Counterparts. This Agreement may be executed in any number of
duplicate originals or counterparts, each of which duplicate original or
counterpart shall be deemed to be an original and all taken together shall
constitute one and the same instrument.

     6.     Loan Documents; Governing Law; Etc. This Agreement is one of the
Loan Documents defined in the Restated Loan Agreement and shall be governed and
construed in accordance with the laws of the State of Maryland. The headings and
captions in this Agreement are for the convenience of the parties only and are
not a part of this Agreement.

     7.     Acknowledgments. The Borrowers hereby confirm to the Lender the
enforceability and validity of each of the Loan Documents. In addition, the
Borrowers hereby agree to the execution and delivery of this Agreement and the
terms and provisions, covenants or agreements contained in this Agreement shall
not in any manner release, impair, lessen, modify, waive or otherwise limit the
liability and obligations of the Borrowers under the terms of any of the Loan
Documents, except as otherwise specifically set forth in this Agreement. The

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Borrowers issue, remake, ratify and confirm the representations, warranties and
covenants contained in the Loan Documents. Nothing in this Agreement shall be
deemed to waive any defaults existing under any of the Loan Documents as of the
date hereof.

     8.     Notices. All notices, certificates or other communications under the
Loan Documents shall be deemed given when received, if given by hand or courier,
or by certified mail, postage prepaid, return receipt requested, addressed as
follows:

      If to the Lender:   Bank of America, N.A.
6610 Rockledge Drive
Third Floor
Bethesda, Maryland 20817
Attn: Jeffrey S. Patch   With a copy to:   Troutman Sanders Mays & Valentine LLP
1660 International Drive, Suite 600
McLean, Virginia 22102
Attn: Richard M. Pollak, Esq.   If to the Borrowers:   BioReliance Corporation
14920 Broschart Road
Rockville, Maryland 20850
Attn: John L. Coker, CFO

     9.     Modifications. This Agreement may not be supplemented, changed,
waived, discharged, terminated, modified or amended, except by written
instrument executed by the parties.

[Signatures are on the next page]

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     IN WITNESS WHEREOF, the parties hereto have signed and sealed this
Agreement on the day and year first above written.

      WITNESS/ATTEST:   BIORELIANCE CORPORATION   /s/ Evdoxia E. Kopsidas   By:
/s/ John L. Coker (SEAL)

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Evdoxia E. Kopsidas       Name: John L. Coker   Controller       Title:
Secretary & Treasurer     WITNESS/ATTEST:   BIORELIANCE TESTING AND DEVELOPMENT,
INC.     /s/ Evdoxia E. Kopsidas   By: /s/ John L. Coker (SEAL)

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Evdoxia E. Kopsidas       Name: John L. Coker   Controller       Title:
Secretary & Treasurer     WITNESS/ATTEST:   BIORELIANCE MANUFACTURING, INC.    
/s/ Evdoxia E. Kopsidas   By: /s/ John L. Coker (SEAL)

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  Evdoxia E. Kopsidas       Name: John L. Coker   Controller       Title:
Secretary & Treasurer     WITNESS/ATTEST:   MAGENTA VIRAL PRODUCTION, INC.    
/s/ Evdoxia E. Kopsidas   By: /s/ John L. Coker (SEAL)

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  Evdoxia E. Kopsidas       Name: John L. Coker   Controller       Title:
Secretary & Treasurer     WITNESS:   BANK OF AMERICA, N.A.     /s/ Donna
Schaffer   By: /s/ Michael J. Radcliffe (SEAL)

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  Donna Schaffer       Name: Michael J. Radcliffe           Title: Vice
President  

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