Exhibit 10.1

Q1 FY11 Management Incentive Plan

The Q1 FY11 Management Incentive Plan (the “Plan”) applies to employees of
Accelrys for achievement of Objectives as defined in this Plan. The Plan is
designed to support the growth and profitability of the organization.

Definitions

 

The Plan:    The Q1 FY11 Management Incentive Plan. The Company:    Refers to
Accelrys Inc. and its affiliates, including Accelrys Ltd, Accelrys SARL,
Accelrys GmbH, Accelrys KK. Plan Participant:    A regular employee of the
Company in the following levels: CEO, Vice President, Director and eligible
members of the Marketing organization; who are not already participating in an
alternative commission or incentive plan and is employed by the Company through
the completion of Q1 FY11. Orders Bookings:    The aggregate of completed
customer purchase orders approved and accepted by the Company as binding
commitments to purchase its product and/or services.

Non-GAAP Operating Income:

   Earnings before Interest and Taxes, excluding certain GAAP items as detailed
by the Company in its filings.

Eligibility & Applicability

To be eligible for participation in the Plan, a Plan Participant must be regular
employee of the Company.

Plan participants who are partial year employees must be employed by the Company
prior to and through the completion of the first quarter of the fiscal year in
order to receive a pro rated payment under the Plan.

Term

This Plan is effective for the quarter ending June 30, 2010.

Plan Structure

Each Plan Participant is eligible to earn a target incentive equal to a
percentage of base salary.

Earnings under the Plan result from successful performance against a combination
of two Financial Metrics (Orders Bookings and non-GAAP Operating Income Targets)
and against Individual Performance Objectives.

The Financial Metrics Component of the Plan is weighted as follows:

 

  •  

Orders Bookings Target = 50% of eligible amount

 

  •  

Non-GAAP operating income Target = 50% of eligible amount

Specific participation in the Plan is accordance with the following:

Vice President-level Participants: funding achievement under the Plan is tied to
the two Financial Metrics (non-GAAP operating income and Orders Bookings Target)
upon which 80% of target bonus is earned. The remaining 20% of target bonus is
subject to individual performance objectives and may be awarded at the sole
discretion of Accelrys’ CEO.

--------------------------------------------------------------------------------

Director-level Plan Participants: 50% of funding achievement under the Plan is
tied to the two Financial Metrics (non-GAAP operating income and Orders Bookings
Target) upon which 50% of target bonus is earned. The remaining 50% of target
bonus is subject to individual performance objectives and may be awarded at the
sole discretion of Accelrys’ CEO.

Marketing Organization Plan Participants: 50% of funding achievement under the
Plan is tied to the two Financial Metrics (non-GAAP operating income and Orders
Bookings Target) upon which 50% of target bonus is earned. The remaining 50% of
target bonus is subject to individual performance objectives and may be awarded
at the sole discretion of Accelrys’ CEO.

The Plan provides eligible participants with the opportunity to earn from 0% to
200% of target incentive.

Payment Schedule

Incentives shall be earned for the applicable fiscal year and shall be paid in
the quarter that follows the quarter in which the incentives are earned.

General Provisions

A Plan Participant shall not assign nor give any part of an incentive to any
agent, customer or representative of the customer, or any other person, as an
inducement in obtaining an order. Unless expressly approved in advance by the
CEO of the Company, a Plan Participant shall not accept any compensation from
third parties related to sales of third party products or services made by the
Company.

In the event that any Plan Participant compensated in accordance with this Plan
owes any sum of money to the Company, including without limitation draw
payments, charge backs, and travel advances, the Company shall have the right at
any time to offset such obligations against the employee’s base salary,
commissions, or bonuses.

The Company reserves the right without advance notice to:

 

  1. Accept, reject, or cancel any order;

 

  2. Make any adjustments or revisions to incentive rates, quotas, salaries, or
any other matters pertaining to this Plan; and

 

  3. Resolve, in its sole and absolute discretion, any matters of interpretation
under the Plan and matters not covered by the provisions of the Plan.

 

  4. Modify or terminate this Plan at any time.

The contents of this Plan are Company Proprietary and Confidential, and are not
to be disclosed by any Plan Participant to any person who is not an employee of
the Company. Any legal action brought concerning this Plan shall be brought only
in the state or federal courts of the country in which the Plan Participant is
employed and both parties submit to venue and jurisdiction in these courts. This
Plan contains the entire agreement of the parties with respect to the matters
addressed herein, and supersedes all other representations, statements and
understandings concerning this subject matter.