Exhibit 10.3
LICENSE AGREEMENT
 
This Agreement is entered into as of August 26, 2010 (“Effective Date”), by and
among Albert Einstein College of Medicine of Yeshiva University, a Division of
Yeshiva University, a corporation organized and existing under the laws of the
State of New York, having an office and place of business at 1300 Morris Park
Avenue, Bronx, New York 10461 (“Einstein”), Massachusetts Institute of
Technology, a Massachusetts corporation organized and existing under the laws of
the State of Massachusetts, having an office and place of business at 77
Massachusetts Avenue, Cambridge, MA 02139-4307 (“MIT”), Cornell University, a
non-profit institution organized and existing under the laws of the State of New
York, having an office and place of business at 395 Pine Tree Road, Ithaca, NY
14850 (“Cornell”), Isituti Fisioterapici Ospitalieri, a company organized and
existing under the laws of Italy, having an office and place of business at Via
Elio Chianesi, 53-00144 Roma, Italy (“IFO”) (Einstein, MIT, Cornell and IFO
shall be referred to individually and collectively as “Licensors”), on the one
hand, and Metastat, Inc., a corporation organized and existing under the laws of
the State of Delaware, having an office and place of business at 4 Autumnwood
Court, The Woodlands, Texas 77380 (“Licensee”), on the other hand.
 
S t a t e m e n t
 
Licensors have developed certain hybridoma cell lines that produce (**) (related
to MIT case # (**); “(**)”, by Frank B. Gertler and Matthias Krause) and are the
owners of patent applications related to (**) and uses thereof in diagnosis,
prognosis and treatment of tumors.  Licensee wishes to acquire an exclusive
license to Licensors’ rights in the aforementioned cell line and patent rights,
and Licensors wish to grant such rights to Licensee.
 
NOW, THEREFORE, in consideration of the promises and mutual covenants,
conditions and limitations herein contained and other good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged,
Licensors and Licensee agree as follows:
 
1. Definitions
 
1.01  
“Agreement Patents” means the patent applications listed on Appendix A, together
with any and all patents and patent applications which issue from or are based
on such patent applications and from any and all divisionals, continuations,
continuations-in-part (but only to the extent the claims thereof are enabled by
disclosure of the parent application) and foreign counterparts of such patents
and patent applications, and any and all reissues, renewals and extensions or
the like of such patents and patent applications and any and all U.S. and
foreign patents which are based on such patents and patent applications.
Appendix A shall be updated from time-to-time by the parties.

 
1.02  
“Cell Line” means a hybridoma cell line that produces (**)

 
1.03  
“Materials” means (**) produced by the Cell Line.

 
1.04  
“Diagnostic Field” means products and services for diagnostic use.

 
1.05  
“Therapeutic Field” means products and services for therapeutic use.

 
1.06  
“Diagnostic Licensed Product” means any product or service in the Diagnostic
Field, the development, manufacture, use, provision or sale of which: (a) is
covered by a claim in an Agreement Patent; and/or (b) utilizes or includes
Materials.

 
 
-1-

--------------------------------------------------------------------------------

 
 
1.07  
“Therapeutic Licensed Product” means any product or service in the Therapeutic
Field, the development, manufacture, use, provision or sale of which: (a) is
covered by a claim in an Agreement Patent; and/or (b) utilizes or includes
Materials.

 
1.08  
“Licensed Product” means, individually and collectively, Diagnostic Licensed
Product and Therapeutic Licensed Product.

 
1.09  
“Net Sales” means the total consideration, in any form, received by Licensee,
Affiliates and Sublicensees as consideration for the sale, lease, provision or
other disposition of Licensed Products by Licensee and/or Affiliates and/or
Sublicensees to an independent third party, less:

 
(a)  
customary and reasonable trade discounts actually taken, refunds, returns and
recalls; and

 
(b)  
when included in gross sales, customary and reasonable freight, shipping,
duties, and sales, V.A.T. and/or use taxes based on sales prices, but not
including taxes when assessed on incomes derived from such sales.

 
If Licensee and/or Affiliates and/or Sublicensees intend to accept from
independent third parties any non-cash consideration as Net Sales, Licensee must
first obtain Licensors’ written approval.  For any non-cash consideration
approved by Licensors and received as Net Sales, the parties will appoint an
independent third party to determine, at Licensee’s expense, the present day
value of such consideration and that value shall be added to Net Sales in place
of the non-cash consideration.
 
In the event that, during a particular calendar quarter, a Licensed Product is
sold in combination with one or more other products, whether or not such other
products are packaged or otherwise physically combined with such Licensed
Product, for a single price (a “Combination Product”), Net Sales from sales of a
Combination Product, for purposes of calculating royalties due under this
Agreement, shall be calculated by multiplying the Net Sales of the Combination
Product by the fraction A/(A+B), where A is the average per unit sales price for
such calendar quarter of the Licensed Product sold separately in the country of
sale and B is the average per unit sales price for such calendar quarter of the
other product(s) sold separately in the country of sale.  In the event that no
separate sales are made of the Licensed Product and/or the other product(s) in
the country of sale, separate sale prices in commensurate countries may be used
instead.  In the event that no separate sales are made of the Licensed Product
and/or the other product(s), Net Sales from sales of a Combination Product, for
purposes of determining royalty payments on such Combination Products, shall be
calculated using the entire Net Sales of such Combination Products.
 
1.10  
“Net Proceeds” shall mean the total consideration, in any form (including, but
not limited to, license signing fees, maintenance fees, milestone and minimum
payments, whether or not such fees and payments are creditable against future
royalties to be paid to Licensee, research and development funds, and just that
portion of the funds received for equity purchases of Licensee which exceeds the
fair market value of the equity; but excluding royalties based on Net Sales of
Sublicensees) that is received by Licensee from a Sublicensee in connection with
the grant to said Sublicensee of rights under the Agreement Patents. If Licensee
intends to accept from a Sublicensee any non-cash consideration as Net Proceeds,
Licensee must first obtain Licensors’ written approval.  For any non-cash
consideration approved by Licensors and received as Net Proceeds, the parties
will appoint an independent third party to determine the present day value of
such consideration and that value shall be added to Net Proceeds in place of the
non-cash consideration.

 
 
-2-

--------------------------------------------------------------------------------

 
 
1.11  
“Affiliate” means any entity, that, directly or indirectly, through one or more
intermediates, controls, is controlled by, or is under common control with
Licensee.  For the purposes of this definition, control shall mean the direct or
indirect ownership of at least fifty percent (50%) of (i) the stock shares
entitled to vote for the election of directors or (ii) ownership interest.

 
1.12  
“Sublicensee” shall mean any non-Affiliate third party to whom Licensee has
granted the right to make and sell (or otherwise dispose of) Licensed Products.

 
1.13  
“Confidential Information” means any information designated as such in writing
by the disclosing party, whether by letter or by the use of an appropriate
proprietary stamp or legend, prior to or at the time any such confidential or
proprietary materials or information are disclosed by the disclosing party to
the recipient.  Notwithstanding the foregoing, information or materials which
are orally or visually disclosed to the recipient by the disclosing party, or
are disclosed in a writing or other tangible form without an appropriate letter,
proprietary stamp or legend, shall constitute Confidential Information if the
disclosing party, within thirty (30) days after such disclosure, delivers to the
recipient a written document or documents describing such information or
materials and referencing the place and date of such oral, visual, written or
other tangible disclosure.

 
1.14  
“Marketable Securities” means shares of the common stock of Licensee that are
listed or quoted for trading on the NASDAQ Global Market, the NASDAQ Global
Select Market, the New York Stock Exchange, or the New York Stock Exchange Amex
(each, a “Trading Market”) (a) all of which the holders thereof would have the
right to sell in a sale registered pursuant to a registration statement under
the Securities Act of 1933, as amended (a “Public Sale”) within 60 days
following their issuance to the holders regardless of any lock-up agreements or
other contractual restrictions on transfer, and (b) all of which can be
reasonably expected to be able to be sold in Public Sales within 60 days of
their issuance without having a material adverse effect upon the market for such
securities.

 
1.15  
“Volume Weighted Average Price” means, for the applicable date, the
price determined by the average of the daily volume weighted average price of
the common stock of Licensee for the twenty (20) consecutive trading days ending
on the trading day immediately before the applicable date on the applicable
Trading Market as reported by Bloomberg L.P., based on a trading day from 9:30
a.m. to 4:02 p.m. (New York City time).

 
2. Licensors’ Agreements With U.S. Government
 
2.01  
Certain of the Licensors, through their employees, have and will perform
research sponsored in part by the United States Government.  As a result of this
government sponsorship of the aforementioned research, the United States
Government retains certain rights in such research as set forth in 35 U.S.C.
§200 et. seq. and applicable regulations.

 
2.02  
The continuance of such government sponsored research by Licensors and their
employees during the term of this Agreement will not constitute a breach of this
Agreement.  All rights reserved to the U.S. Government under 35 U.S.C. §200 et.
seq. and applicable regulations shall remain so reserved and shall in no way be
affected by this Agreement. Licensors and their employees are not obligated
under this Agreement to take any action which would conflict in any respect with
their past, current or future obligations to the U.S. Government as to work
already performed and to be performed in the future.

 
 
-3-

--------------------------------------------------------------------------------

 
 
3. Agreement Patents
 
3.01  
Within ninety (90) day of the Effective Date, Licensee will reimburse Licensors
for all expenses incurred prior to the Effective Date in connection with the
preparation, filing, prosecution and maintenance of the Agreement
Patents.  Amounts paid by Licensee pursuant to this Section 3.01 are
non-refundable and not creditable against any other payment due to Licensors.

 
3.02  
As of and after the Effective Date, Licensee will pay the cost of preparing,
filing, prosecuting, maintaining and resisting challenges to the validity of the
Agreement Patents (as well as the cost of preparing, filing, prosecuting,
maintaining and resisting challenges to the validity of corresponding
applications in at least the United States, Europe (an EPO filing designating
all member countries), Canada, Japan, and Australia, and in such other
jurisdictions as Licensee shall determine), using patent counsel selected by
Licensors.  Such payments will be due within thirty (30) days of Licensee’s
receipt of an invoice from Licensors relating to said costs.  Licensee will pay
the cost of defending and/or prosecuting any interference, reexamination,
reissue, opposition, cancellation and nullity proceedings involving Agreement
Patents.  Licensors will keep Licensee informed concerning such patents and
applications and will consult with Licensee concerning the preparation, filing,
prosecution, maintenance and challenges to the validity of such patents and
applications.  Licensee shall cooperate with any reasonable request of Licensors
in connection with any such preparation, filing, prosecution, maintenance and/or
defense.  In the event that Licensee elects not to maintain, defend or prosecute
any patent or patent application within the Agreement Patents, Licensee shall
give Licensors thirty (30) days prior written notice of such election.  Any
patents or patent applications so elected shall at the end of the notice period
cease to be considered Agreement Patents, and Licensors shall then be free, at
their election, to abandon or maintain the prosecution of such patent
application or issued patent or grant rights to such patent application or
issued patent to third parties.

 
3.03  
Amounts paid by Licensee pursuant to Section 3.02 will be non-refundable and not
creditable against any other payment due to Licensors.

 
4. License Grant
 
4.01  
Subject to Article 2, Licensors hereby grant to Licensee and Affiliates: (a) a
worldwide, exclusive license to use (but not to sell or transfer) the Cell Line
to make Materials for use in connection with Licensed Products; (b) a worldwide,
exclusive license to make, use, offer to sell and sell Materials in connection
with Licensed Products; and (c) a worldwide, exclusive license to Licensors’
rights in the Agreement Patents, along with the right by Licensee only to grant
sublicenses, to make, have made, use, have used, provide, import, have imported,
offer to sell, sell and have sold Licensed Products. Licensee will not grant any
sublicense (or amend any sublicense) under Agreement Patents unless it first
submits a full and complete draft of any such proposed sublicense (or amendment)
to Licensors and then receives the prior written consent of Licensors.  Licensee
shall provide Licensors with a full and complete copy of any approved sublicense
(or amendment) within thirty (30) days of execution thereof by Licensee. The
terms of any sublicense agreement shall be consistent with the terms of this
Agreement and shall include (at least) the following provisions: prohibiting any
use of Licensors’ names (consistent with Section 9.01), requiring
indemnification of Licensors (consistent with Section 12.04), requiring
appropriate insurance (consistent with Section 12.09), and disclaiming any
warranties or representations by Licensors (consistent with Sections 12.05 and
12.06).

 
4.02  
Notwithstanding the exclusive rights granted to Licensee pursuant to Section
4.01, Licensors shall retain the right to make, use and practice:  (i) Agreement
Patents; and (ii) the Cell Line and Materials in their own laboratories solely
for non-commercial scientific purposes and for continued non-commercial
research.  Further, Licensors shall have the right to make available to
not-for-profit scientific institutions and non-commercial researchers materials
covered under Agreement Patents and the Materials, solely for non-commercial
scientific and research purposes, provided this is done under a material
transfer agreement.

 
 
-4-

--------------------------------------------------------------------------------

 
 
4.03  
Nothing contained in this Agreement shall be construed or interpreted as a
grant, by implication or otherwise, of any license except as expressly specified
in Section 4.01 hereof.  Licensee will not transfer the Cell Line to any third
party or use the Cell Line or the Materials except as permitted by this
Agreement. The license granted herein shall apply to the Licensee and
Affiliates, except that Affiliates shall not have the right to grant
sublicenses.  If any Affiliate exercises rights under this Agreement, such
Affiliate shall be bound by all terms and conditions of this Agreement,
including but not limited to indemnity and insurance provisions, which shall
apply to the exercise of the rights, to the same extent as would apply had this
Agreement been directly between Licensors and the Affiliate.  In addition,
Licensee shall remain fully liable to Licensors for all acts and obligations of
Affiliates such that acts of Affiliates shall be considered the acts of
Licensee.

 
4.04  
Within (**) (**) months of Licensee’s request, Licensors will provide the Cell
Line to Licensee using the shipper specified by and at the expense of
Licensee.  Licensee shall be responsible for all documentation required by
customs officials in the United States of America or the equivalent in any
relevant foreign jurisdiction.

 
5. Confidentiality
 
5.01  
Nothing herein contained shall preclude Licensors from making required reports
or disclosures to the NIH or to any other philanthropic or governmental funding
organization, provided, however, that no Licensee Confidential Information is
disclosed in the process.

 
5.02  
Licensee will retain in confidence Confidential Information of Licensors and
Licensee will not disclose any such Confidential Information to any third party
without the prior written consent of Licensors, except that Licensee shall have
the right to disclose such information to any third party for commercial or
research and development purposes under written terms of confidentiality and
non-disclosure which are commercially reasonable.  Licensee will keep
confidential all Confidential Information of Licensors for a period of (**) (**)
years after termination or expiration of this Agreement, provided, however, that
the obligation of confidentiality will not apply to any such information which:

 
(a)  
was known to Licensee or generally known to the public prior to its disclosure
hereunder; or

 
(b)  
subsequently becomes known to the public by some means other than a breach of
this Agreement, including but not limited to publication and/or laying open to
inspection of any patent applications or patents; or

 
(c)  
is subsequently disclosed to Licensee by a third party having a lawful right to
make such disclosure; or

 
(d)  
is required to be disclosed by regulation, law or court order to the most
limited extent necessary to comply therewith, provided Licensors are given a
fair opportunity to defend against such disclosure; or

 
(e)  
is independently developed by Licensee as evidenced by Licensee’s written
records.

 
 
-5-

--------------------------------------------------------------------------------

 
 
5.03  
During the term of this Agreement, it is contemplated that Licensors may become
aware of Confidential Information of Licensee (“Licensee Confidential
Information”).  Licensors agree to retain such Licensee Confidential Information
in confidence and not to disclose any such Licensee Confidential Information to
a third party without prior written consent of Licensee for a period ending (**)
(**) years after termination or expiration of this Agreement, except that such
obligations shall not apply to any information which:

 
(a)  
was known to Licensors or generally known to the public prior to their
disclosure hereunder; or

 
(b)  
subsequently becomes known to the public by some means other than a breach of
this Agreement; or

 
(c)  
is subsequently disclosed to Licensors by a third party having a lawful right to
make such disclosure; or

 
(d)  
is required to be disclosed by regulation, law or court order to the most
limited extent necessary to comply therewith, provided Licensee is given a fair
opportunity to defend against such disclosure; or

 
(e)  
is independently developed by Licensors as evidenced by Licensors’ written
records.

 
6. Royalties and Payments
 
6.01  
Licensee shall make the following payments to Licensors:

 
(a)  
Licensee will pay to Licensors (**) percent (**%) of Net Sales.

 
(i)  
Royalty Offset/Stacking Royalties. In the event that, with respect to Net Sales
of Licensed Products, Licensee is paying royalties to unaffiliated third parties
for patent rights such that the practice of the Agreement Patent(s) would
infringe such rights, the amount due and payable to Licensor hereunder shall be
proportionally reduced by (**) per cent (**%) due such third party, but in no
event shall the Royalty payable to Licensors be less than (**) per cent (**%) of
net sales. By example, if the royalty due other third parties equals (**) per
cent (**%) of Net Sales, the Royalty due Licensor shall be (**) per cent (**%);
if the royalty due other third parties equals (**) per cent (**%) of Net Sales,
the Royalty due Licensors shall be (**) per cent (**%).

 
(b)  
Licensee will pay to Licensors twenty percent (**%) of Net Proceeds received by
Licensee.

 
6.02  
Upon execution of this Agreement by the parties, Licensee shall issue to
Licensors or their designees an aggregate number of shares (the “Shares”) of the
common stock of Licensee equal to (**) percent (**%) of Licensee’s issued and
outstanding common stock calculated on a fully diluted, as converted basis.  The
Shares shall be issued to Licensors or their designees pursuant to a separate
stock subscription agreement among Licensee and Licensors, and Licensee,
Licensors and certain other stockholders of Licensee shall enter into a
stockholders agreement.

 
 
-6-

--------------------------------------------------------------------------------

 
 
6.03  
Licensee shall make the following license signing and license maintenance
payments to Licensors:

 
(a)  
Upon execution of this Agreement by the parties, Licensee will pay to Licensors
(**) Dollars (US$**) as a license signing fee, which payment is non-refundable
and not creditable against any other payment due to Licensors pursuant to this
Agreement.

 
(b)  
On each of the first, second, third and fourth anniversaries of the Effective
Date, Licensee will pay to Licensors (**) Dollars (US$**) as a license
maintenance fee. This payment is non-refundable but is creditable against actual
royalties and payments due to Licensors pursuant to Section 6.01 during the
twelve (12) month period following each such anniversary.

 
(c)  
On the fifth anniversary of the Effective Date, Licensee will pay to Licensors
(**) Dollars (US$**) as a license maintenance fee.  This payment is
non-refundable but is creditable against actual royalties and payments due to
Licensors pursuant to Section 6.01 during the twelve (12) month period following
this anniversary.

 
(d)  
On the sixth anniversary of the Effective Date, Licensee will pay to Licensors
(**) Dollars (US$**) as a license maintenance fee.  This payment is
non-refundable but is creditable against actual royalties and payments due to
Licensors pursuant to Section 6.01 during the twelve (12) month period following
this anniversary.

 
(e)  
On the seventh anniversary of the Effective Date and every anniversary of the
Effective Date thereafter, Licensee will pay to Licensors (**) Dollars (US$**)
as a license maintenance fee.  Each such payment is non-refundable but is
creditable against actual royalties and other payments due to Licensors pursuant
to Section 6.01 during the twelve (12) month period following each such
anniversary.

 
6.04  
Licensee shall make the following milestone payments to Licensors for Diagnostic
Licensed Products:

 
(a)  
Upon each request by Licensee or an Affiliate for marketing clearance for each
Diagnostic Licensed Product (or each indication for a Diagnostic Licensed
Product) in any country, Licensee shall either (i) pay to Licensors (**) Dollars
(US$**) in cash or, at Licensee’s option, (ii) issue to Licensors or their
designees Marketable Securities having an aggregate value of (**) Dollars
(US$**) as of the date of the request for the applicable marketing clearance,
determined using a Volume Weighted Average Price.  Notwithstanding the
foregoing, if no such request for marketing clearance has occurred by (**) (**)
years from the Effective Date, then Licensee shall pay to Licensors (**) Dollars
(US$**); and

 
(b)  
Upon the first commercial sale of each Diagnostic Licensed Product (or each
indication for a Diagnostic Licensed Product) by Licensee or an Affiliate,
Licensee shall either (i) pay to Licensors (**) Dollars (US$**) in cash or, at
Licensee’s option, (ii) issue to Licensors or their designees Marketable
Securities having an aggregate value of (**) Dollars (US$**) as of the date of
such sale, determined using a Volume Weighted Average Price.  Notwithstanding
the foregoing, if no such commercial sale has occurred by (**) (**) years from
the Effective Date, then Licensee shall pay to Licensors (**) Dollars (US$**).

 
(c)  
The payments or issuances of Marketable Securities pursuant to Sections 6.04(a)
and (b) are non-refundable and not creditable against any other payment due to
Licensors.

 
 
-7-

--------------------------------------------------------------------------------

 
 
6.05  
Licensee shall make the following milestone payments to Licensors for
Therapeutic Licensed Products:

 
(a)  
Upon the initiation by Licensee or an Affiliate of the first Phase (**) clinical
trial (or its foreign equivalent) for each Therapeutic Licensed Product (or each
indication for a Therapeutic Licensed Product) anywhere in the world, Licensee
shall either (i) pay to Licensors (**) Dollars (US$**) in cash or, at Licensee’s
option, (ii) issue to Licensors or their designees Marketable Securities having
an aggregate value of (**) Dollars (US$**) as of the date of the initiation of
such clinical trial, determined using a Volume Weighted Average
Price.  Notwithstanding the foregoing, if no such Phase (**) clinical trial has
occurred by (**) (**) years from the Effective Date, then Licensee shall pay to
Licensors (**) Dollars (US$**);

 
(b)  
Upon the initiation by Licensee or an Affiliate of the first Phase (**) clinical
trial (or its foreign equivalent) for each Therapeutic Licensed Product (or each
indication for a Therapeutic Licensed Product) anywhere in the world, Licensee
shall either (i) pay to Licensors (**) Dollars (US$**) in cash or, at Licensee’s
option, (ii) issue to Licensors or their designees Marketable Securities having
an aggregate value of (**) Dollars (US$**) as of the date of the initiation of
such clinical trial, determined using a Volume Weighted Average
Price.  Notwithstanding the foregoing, if no such Phase (**) clinical trial has
occurred by (**) (**) years from the Effective Date, then Licensee shall pay to
Licensors (**) Dollars (US$**);

 
(c)  
Upon the submission of a new drug application to the FDA (or its foreign
equivalent) for each Therapeutic Licensed Product (or each indication for a
Therapeutic Licensed Product), Licensee shall either (i) pay to Licensors (**)
Dollars (US$**) in cash or, at Licensee’s option, (ii) issue to Licensors or
their designees Marketable Securities having an aggregate value of (**) Dollars
(US$**) as of the date of such submission, determined using a Volume Weighted
Average Price.  Notwithstanding the foregoing, if no such new drug application
has been submitted to the FDA by (**) (**) years from the Effective Date, then
Licensee shall pay to Licensors (**) Dollars (US$**);

 
(d)  
Upon first commercial sale of each Therapeutic Licensed Product (or each
indication for a Therapeutic Licensed Product) by Licensee or an Affiliate,
Licensee shall either (i) pay to Licensors (**) Dollars (US$**) in cash or, at
Licensee’s option, (ii) issue to Licensors or their designees Marketable
Securities having an aggregate value of (**) Dollars (US$**) as of the date of
such sale, determined using a Volume Weighted Average Price; and

 
(e)  
The payments or issuances of Marketable Securities due pursuant to Sections
6.05(a) - (d) are non-refundable and not creditable against any other payment
due to Licensors.

 
6.06  
Only one royalty will be payable on Net Sales by Licensee and Affiliates and
Sublicensees on a Licensed Product under Section 6.01(a), regardless of the
number of patent claims in Agreement Patents which cover such Licensed Product.

 
6.07  
Licensee’s failure to pay full royalties, transfer stock or make complete
payments under Sections 6.01, 6.02, 6.03, 6.04 or 6.05 shall be a breach of this
Agreement.

 
7. Payment Reports and Records
 
7.01  
All cash payments required to be made by Licensee to Licensors pursuant to this
Agreement shall be made to Licensors in U.S. Dollars by wire transfer or by
check payable to Einstein and sent to Einstein’s address set out in Section
13.01. All Shares and Marketable Securities shall be issued to Licensors or
their designees at Licensors’ respective addresses set out in Section 13.01 or
at such address(es) provided to Licensee by Licensors as follows: (a) one-third
(1/3) to Einstein; (b) one-third (1/3) to MIT; (c) two-ninths (2/9) to IFO; and
(d) one-ninth (1/9) to Cornell.

 
 
-8-

--------------------------------------------------------------------------------

 
 
7.02  
All payments required to be made by Licensee to Licensors (or their designees)
pursuant to this Agreement shall be subject to a charge of one and one-half
percent (1.5%) per month or Two Hundred and Fifty Dollars (US$250), whichever is
greater, if late.  Conversion of foreign currency to U.S. dollars shall be made
at the conversion rate quoted by the Wall Street Journal, averaged on the last
business day of each of the three (3) consecutive calendar months constituting
the calendar quarter in which the payment was earned.  Licensee will bear any
loss of exchange or value and pay any expenses incurred in the transfer or
conversion to U.S. dollars.

 
7.03  
Payment due from Licensee to Licensors pursuant to Section 6.01 will be paid
within thirty (30) days after the end of each calendar year quarter during which
the payment accrued.  If no royalties or other payments are due for any quarter,
Licensee will send a statement signed by an officer of Licensee to that effect
to Licensors.  Payment shall be accompanied by a statement of the number of
Licensed Products and Combination Products sold by Licensee, Affiliates and
Sublicensees in each country, total billings for such Licensed Products and
Combination Products, the values of A and B used to calculate the Net Sales of
Combination Products, deductions applicable to determine the Net Sales thereof,
the amount of Net Sales and Net Proceeds realized by Licensee and Affiliates and
Sublicensees, the amount of any deduction and a detailed listing thereof, and
the total payment due from Licensee to Licensors (the “Royalty Report”).  Such
Royalty Report shall be signed by an officer of Licensee. Licensee shall send
copies of the Royalty Report to MIT, Cornell and IFO at the same time the Report
is sent to Einstein.

 
7.04  
Licensee and Affiliates shall maintain complete and accurate books of account
and records showing Net Sales and Net Proceeds.  Such books and records of
Licensee and Affiliates shall be open to inspection, in confidence, during usual
business hours, upon at least ten (10) business days prior notice to Licensee,
by an independent certified public accountant appointed by Licensors on behalf
of Licensors, who has entered into a written agreement of confidentiality with
Licensors which is no less protective of Licensee’s Confidential Information
than the provisions of Section 5.03 hereof and to whom Licensee has no
reasonable objection, for five (5) years after the calendar year to which they
pertain, for the purpose of verifying the accuracy of the payments made to
Licensors by Licensee pursuant to this Agreement.  Licensee will require any
Sublicensees hereunder to maintain such books and allow such inspection by
Licensee and shall, on request, disclose such information, if available to
Licensee, to Licensors as part of such inspection.  Inspection shall be at
Licensors’ sole expense and reasonably limited to those matters related to
Licensee’s payment obligations under this Agreement and shall take place not
more than once per calendar year.  Any underpayment revealed by any inspection,
plus interest on the underpayment amount at the rate of one and one-half percent
(1.5%) per month or Two Hundred and Fifty Dollars (US$250), whichever is
greater, shall be promptly paid by Licensee to Licensors.  Further, if any
inspection reveals an underpayment to Licensors of ten percent (10%) or greater,
then the cost of the inspection shall be paid by Licensee.

 
8. Infringement
 
8.01  
Licensee shall have the right, in its sole discretion and its expense, to
initiate legal proceedings on its behalf or in Licensors’ names, if necessary,
against any infringer, or potential infringer, of an Agreement Patent who
imports, makes, uses, sells or offers to sell products.  Licensee shall notify
Licensors of its intention to initiate such proceedings at least twenty (20)
days prior to commencement thereof.  Any settlement or recovery received from
any such proceeding shall be divided (**) percent (**%) to Licensee and (**)
percent (**%) to Licensors after Licensee deducts from any such settlement or
recovery its actual counsel fees and out-of-pocket expenses relative to any such
legal proceeding.  If Licensee decides not to initiate legal proceedings against
any such infringer, then Licensors shall have the right to initiate such legal
proceedings.  Any settlement or recovery received from any such proceeding
initiated by Licensors shall be divided (**) percent (**%) to Licensee and (**)
percent (**%) to Licensors after Licensors deduct from any such settlement or
recovery their actual counsel fees and out-of-pocket expenses relative to any
such legal proceeding.

 
 
-9-

--------------------------------------------------------------------------------

 
 
8.02  
In the event that any party initiates or carries on legal proceedings to enforce
any Agreement Patent against an alleged infringer, the other parties shall fully
cooperate with and supply all assistance reasonably requested at the expense of
the party requesting such assistance.  Further, the other parties, at their
expense, shall have the right to be represented by counsel of their choice in
any such proceeding.  However, if Licensee initiates legal proceedings in
Licensors’ name, Licensee shall reimburse Licensors for any reasonable
out-of-pocket counsel fees of Licensors associated with the legal
proceedings.  The party who initiates or carries on the legal proceedings shall
have the sole right to conduct such proceedings provided, however, that such
party shall consult with the other parties to this Agreement prior to entering
into any settlement thereof.

 
9. Prohibition on Use of Names; No Publicity
 
9.01  
No party to this Agreement shall use the name of any other party without the
prior written consent of such other party, except if the use of such name is
required by law, regulation, federal securities law, or judicial order, in which
event the party intending to use such name will promptly inform the relevant
other party prior to any such required use.  No party to this Agreement will
make any public announcement regarding the existence of this Agreement and/or
the collaboration hereunder without obtaining the prior written consent of the
other parties, except if such announcement is required by law, regulation,
federal securities law or judicial order, in which event the party intending to
make such announcement will promptly inform the other parties prior to such
announcement.

 
10. Term and Termination
 
10.01  
Unless terminated earlier under other provisions hereof, this Agreement will
expire upon the expiration of the last Agreement Patent.  Upon termination or
expiration of this Agreement for any reason, Sections 5, 9, 10.08, 10.09, 12.01
through 12.10, 12.13 and 13 shall survive and all payment obligations under
Articles 3 and 6 hereof accrued as of the termination date shall be paid by
Licensee within thirty (30) days of such termination or expiration.

 
10.02  
Licensee may terminate this Agreement and the licenses granted hereunder by
giving notice to Licensors sixty (60) days prior to such termination.  Upon such
termination, Licensee shall not use Agreement Patents, the Cell Line or the
Materials for any purpose and all of Licensee’s rights in Agreement Patents, the
Cell Line and the Materials shall be terminated.  Further, the Cell Line and all
Materials in Licensee’s possession shall be immediately destroyed (with written
confirmation to Licensors) or returned to Licensors at the expense of Licensee.

 
10.03  
If Licensors or Licensee defaults on or breaches any condition of this
Agreement, the aggrieved party may serve notice upon the other parties of the
alleged default or breach.  If such default or breach is not remedied within
sixty (60) days from the date of such notice, the aggrieved party may at its
election terminate this Agreement.  Any failure to terminate hereunder shall not
be construed as a waiver by the aggrieved party of its right to terminate for
future defaults or breaches.  Licensee’s damages for any breach of this
Agreement by Licensors will be limited to a reduction or suspension of the
payment obligations of Licensee hereunder.  Upon termination of this Agreement
by Licensors pursuant to this Section 10.03, the licenses granted by Licensors
to Licensee shall terminate and Licensee shall not use Agreement Patents, the
Cell Line or the Materials for any purpose and all of Licensee’s rights in
Agreement Patents, the Cell Line and the Materials shall be
terminated.  Further, the Cell Line and all Materials in Licensee’s possession
shall be immediately destroyed (with written confirmation to Licensors) or
returned to Licensors at the expense of Licensee.

 
 
-10-

--------------------------------------------------------------------------------

 
 
10.04  
If Licensee makes an assignment for the benefit of creditors or if proceedings
for a voluntary bankruptcy are instituted on behalf of Licensee or if Licensee
is declared bankrupt or insolvent, Licensors may, at their election, terminate
this Agreement by notice to Licensee.  Upon termination of this Agreement by
Licensors pursuant to this Section 10.04, the licenses granted by Licensors to
Licensee shall terminate and Licensee shall not use Agreement Patents, the Cell
Line or the Materials for any purpose and all of Licensee’s rights in Agreement
Patents, the Cell Line and the Materials shall be terminated.  Further, the Cell
Line and all Materials in Licensee’s possession shall be immediately destroyed
(with written confirmation to Licensors) or returned to Licensors at the expense
of Licensee.

 
10.05  
If Licensee is convicted of a felony relating to the manufacture, use or sale of
Licensed Products or a felony relating to moral turpitude, Licensors may, at
their election, terminate this Agreement by notice to Licensee.  Upon
termination of this Agreement by Licensors pursuant to this Section 10.05, the
licenses granted by Licensors to Licensee shall terminate and Licensee shall not
use Agreement Patents, the Cell Line or the Materials for any purpose and all of
Licensee’s rights in Agreement Patents, the Cell Line and the Materials shall be
terminated.  Further, the Cell Line and all Materials in Licensee’s possession
shall be immediately destroyed (with written confirmation to Licensors) or
returned to Licensors at the expense of Licensee.

 
10.06  
Notwithstanding the provisions of Section 10.03 hereof, should Licensee fail to
pay Licensors any cash, or issue to Licensors or their designees any Marketable
Securities, as applicable, when due and payable under this Agreement, then upon
thirty (30) days written notice Licensors may, at their election, terminate this
Agreement, unless within the thirty (30) day period all delinquent amounts
together with interest due and unpaid have been paid in cash, or issued in
Marketable Securities (as applicable), by Licensee.  Upon termination of this
Agreement by Licensors pursuant to this Section 10.06, the licenses granted by
Licensors to Licensee shall terminate and Licensee shall not use Agreement
Patents, the Cell Line or the Materials for any purpose and all of Licensee’s
rights in Agreement Patents, the Cell Line and the Materials shall be
terminated.  Further, the Cell Line and all Materials in Licensee’s possession
shall be immediately destroyed (with written confirmation to Licensors) or
returned to Licensors at the expense of Licensee.

 
10.07  
Termination of this Agreement by Licensee or Licensors shall not prejudice the
rights of the parties accruing herein.

 
10.08  
If Licensee terminates this Agreement pursuant to Section 10.02 or if Licensors
terminate this Agreement pursuant to Sections 10.03, 10.04, 10.05 or 10.06, then
Licensee shall, upon such termination, assign to Licensors all right, title and
interest in and to any Dependent Patents and Dependent Know-How (as defined
below) developed by or for Licensee or Affiliates during the term of this
Agreement, and shall, within thirty (30) days of termination, provide copies of
all documents and other materials embodying Dependent Know-How to Licensors.  As
used in this Section 10.08, the term “Dependent Patents” means any U.S. or
foreign patent application or patent which claims an invention the practice of
which would infringe a claim of a patent or patent application of the Agreement
Patents or the practice of which results in a product covered by a claim of a
patent or patent application of Agreement Patents.  “Dependent Know-How” means
confidential information, including clinical trial information, the practical
application of which would infringe a claim of a patent or patent application of
Agreement Patents, or which results in a product covered by a claim of a patent
or patent application of Agreement Patents. Licensee agrees to take all actions
and execute any and all documents reasonably requested by Licensors to
effectuate the terms of this Section 10.08.  During the time period between
notice of termination and the effective date of termination Licensee will take
whatever actions are necessary to prevent any Dependent Patent from becoming
abandoned or canceled.

 
10.09  
If Licensee terminates this Agreement pursuant to Section 10.02 or if Licensors
terminate this Agreement pursuant to Sections 10.03, 10.04, 10.05 or 10.06,
Licensee shall submit a final Royalty Report to Licensors and any payments and
patent costs due to Licensors hereunder as of the date of termination shall be
payable within thirty (30) days of the date of termination. In addition, within
ten (10) days of notice of such termination, Licensee shall provide Licensors
with a report showing the status of all Dependent Patents, including, without
limitation, a list of all countries where Dependent Patents have been filed and
a list of all actions which must be taken with respect to the Dependent Patents
and relevant due dates.

 
10.10  
Notwithstanding any provision herein to the contrary, no termination of this
Agreement shall be construed as a termination of any valid sublicense of any
Sublicensee hereunder, and thereafter each such Sublicensee shall be considered
a direct licensee of Licensors, provided that (i) such Sublicensee is not in
material breach of its sublicense agreement with Licensee, and (ii) such
Sublicensee agrees in writing to assume all applicable obligations of Licensee
under this Agreement.

 
11. Amendment and Assignment
 
11.01  
This Agreement sets forth the entire understanding between Licensors, on the one
hand, and Licensee on the other hand, pertaining to the subject matter hereof
and, with respect to Licensee only, supersedes and replaces the Confidential
Disclosure and Non-Use Agreement between Licensor and Warren C. Lau having an
effective date of April 2, 2009.

 
11.02  
Except as otherwise provided herein, this Agreement may not be amended,
supplemented or otherwise modified, except by an instrument in writing signed by
both parties.

 
11.03  
Without the prior written approval of the other parties, which approval shall
not be unreasonably withheld, no party may assign this Agreement except that
this Agreement may be assigned to an entity acquiring substantially all of such
party’s business to which this Agreement relates, or in the event of a merger,
consolidation, change in control or similar transaction of such party.  Any
attempted assignment in contravention of this Section 11.03 shall be null and
void.

 
12. Miscellaneous Provisions
 
12.01  
This Agreement shall be construed and the rights of the parties governed in
accordance with the laws of the State of New York, excluding its law of conflict
of laws.  Any dispute or issue arising hereunder, including any alleged breach
by any party, shall be heard, determined and resolved by an action commenced in
the state or federal courts in New York, New York, which the parties hereby
agree shall have proper jurisdiction and venue over the issues and the
parties.  Licensors and Licensee hereby agree to submit to the jurisdiction of
the state or federal courts in New York and waive the right to make any
objection based on jurisdiction or venue.  The New York courts shall have the
right to grant all relief to which Licensors and Licensee are or shall be
entitled hereunder, including all equitable relief as the Court may deem
appropriate.

 
12.02  
This Agreement has been prepared jointly.

 
12.03  
If any term or provision of this Agreement or the application thereof to any
person or circumstance shall to any extent be invalid or unenforceable, the
remainder of this Agreement or the application of such term or provision to
persons or circumstances other than those as to which it is held invalid or
unenforceable shall not be affected thereby and each term and provision of this
Agreement shall be valid and enforced to the fullest extent permitted by law.

 
 
-11-

--------------------------------------------------------------------------------

 
 
12.04  
Licensee agrees to indemnify Licensors and their current or former directors,
governing board members, trustees, officers, faculty, medical and professional
staff, employees, students and agents and their respective successors, heirs and
assigns (Licensors and each such person being the “Indemnified Parties”) for the
cost of defense and for damages awarded and losses and liabilities incurred, if
any, as a result of any third party claims, liabilities, suits or judgments
based on or arising out of the research, development, marketing, manufacture,
sale and/or provision of the Cell Line and/or the Materials and/or Licensed
Products by Licensee, Affiliates and Sublicensees, and/or the licenses granted
under this Agreement, or otherwise related to the conduct of Licensee’s,
Affiliates’ or Sublicensees’ business, so long as such claims, liabilities,
suits, or judgments are not solely attributable to grossly negligent or
intentionally wrongful acts or omissions by the Indemnified Parties.  This
indemnity is conditioned upon Licensors’ obligation to: (i) advise Licensee of
any claim or lawsuit, in writing promptly after Licensors have or the
Indemnified Party has received notice of said claim or lawsuit, (ii) assist
Licensee and its representatives, at Licensee’s expense, in the investigation
and defense of any lawsuit and/or claim for which indemnification is provided,
and (iii) permit Licensee to control the defense of such claim or lawsuit for
which indemnification is provided.

 
12.05  
Nothing in this Agreement is or shall be construed as:

 
(a)  
A warranty or representation by Licensors that anything made or used by Licensee
under any license granted in this Agreement (including, without limitation, the
Cell Line, the Materials and Licensed Products) is or will be free from
infringement of patents, copyrights, and other rights of third parties; or

 
(b)  
Granting by implication, estoppel, or otherwise any license, right or interest
other than as expressly set forth herein.

 
12.06  
Except as expressly set forth in this Agreement, the parties MAKE NO
REPRESENTATIONS AND EXTEND NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED,
EITHER IN FACT OR BY OPERATION OF LAW, STATUTE OR OTHERWISE, AND THE PARTIES
SPECIFICALLY DISCLAIM ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A
PARTICULAR PURPOSE, OR WARRANTY OF NON-INFRINGEMENT.  IN ADDITION, NO PARTY
SHALL BE LIABLE FOR ANY SPECIAL, INDIRECT, INCIDENTAL OR CONSEQUENTIAL DAMAGES,
HOWEVER CAUSED, UNDER ANY THEORY OF LIABILITY AND WHETHER OR NOT SUCH PARTY HAS
BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES.

 
 
IN PARTICULAR, IN NO EVENT SHALL LICENSORS, THEIR RESPECTIVE TRUSTEES,
DIRECTORS, OFFICERS, EMPLOYEES OR AFFILIATES BE LIABLE FOR INCIDENTAL OR
CONSEQUENTIAL DAMAGES OF ANY KIND, INCLUDING ECONOMIC DAMAGES OR INJURY TO
PROPERTY AND LOST PROFITS, REGARDLESS OF WHETHER LICENSORS SHALL BE ADVISED,
SHALL HAVE OTHER REASON TO KNOW, OR IN FACT SHALL KNOW OF THE POSSIBILITY OF THE
FOREGOING.

 
12.07  
Licensors and Licensee represent and warrant that, to the best of their
knowledge, as of the Effective Date:

 
(a)  
they have the legal right and authority to enter into this Agreement and to
perform all of their obligations hereunder;

 
(b)  
when executed by all parties, this Agreement will constitute a valid and legally
binding obligation and shall be enforceable in accordance with its terms; and

 
(c)  
there are no existing or threatened actions, suits or claims pending or
threatened against them that may affect the performance of their obligations
under the Agreement.

 
12.08  
Licensee represents and warrants that it has not relied on any information
provided by Licensors or Licensors’ current or former employees and has
conducted its own due diligence investigation to its own satisfaction prior to
entering into this Agreement.

 
 
-12-

--------------------------------------------------------------------------------

 
 
12.09  
Licensee represents and warrants that before Licensee, or an Affiliate or a
Sublicensee makes any sales of Licensed Products or performs or causes any third
party to perform any clinical trials or tests in human subjects involving
Licensed Products, Licensee or Affiliates or Sublicensees will acquire and
maintain in each country in which Licensee or Affiliates or Sublicensees shall
test or sell Licensed Products, appropriate insurance coverage reasonably
acceptable to Licensors, but providing coverage in respect of Licensed Products
in an amount no less than (**) (US $**) per claim.  Licensee or Affiliates will
not perform, or cause any third party to perform, any clinical trials or any
tests in human subjects involving Licensed Products unless and until he/they
obtain(s) all required regulatory approvals with respect to Licensed Products in
the applicable countries.  Prior to instituting any clinical trials or any tests
in human subjects, or sale of any Licensed Product, Licensee shall provide
evidence of such insurance to Licensors.  If Licensors determine that such
insurance is not reasonably appropriate, they shall so advise Licensee and
Licensee shall delay such trials, tests or sales until the parties mutually
agree that reasonably appropriate coverage is in place.  Licensors shall be
listed as additional insureds in Licensee’s insurance policies.  If such
insurance is underwritten on a ‘claims made’ basis, Licensee agrees that any
change in underwriters during the term of this Agreement will require the
purchase of ‘prior acts’ coverage to ensure that coverage will be continuous
throughout the term of this Agreement.

 
12.10  
Licensee shall exercise its rights and perform its obligations hereunder in
compliance with all applicable laws and regulations.  In particular, it is
understood and acknowledged that the transfer of certain commodities and
technical data is subject to United States laws and regulations controlling the
export of such commodities and technical data, including all Export
Administration Regulations of the United States Department of Commerce. These
laws and regulations, among other things, prohibit or require a license for the
export of certain types of technical data to certain specified
countries.  Licensee hereby agrees and gives written assurance that he will
comply with all United States laws and regulations controlling the export of
commodities and technical data, that he will be solely responsible for any
violation of such by Licensee or Affiliates or Sublicensees, and that he will
defend and hold Licensors harmless in the event of any legal action of any
nature occasioned by such violation.

 
12.11  
Licensee agrees (i) to obtain all regulatory approvals required for the
manufacture and sale of Licensed Products prior to marketing or selling any such
Licensed Products and (ii) to utilize legally appropriate patent marking on such
Licensed Products.  Licensee agrees to register or record this Agreement as is
required by law or regulation in any country where the license is in effect.

 
12.12  
Licensee agrees that any Licensed Products for use or sale in the United States
will be manufactured substantially in the United States.

 
12.13  
Any tax required to be withheld under the laws of any jurisdiction on royalties
payable to Licensors by Licensee under this Agreement will be promptly paid by
Licensee for and on behalf of Licensors to the appropriate governmental
authority, and Licensee will furnish Licensors with proof of payment of the tax
together with official or other appropriate evidence issued by the competent
governmental authority sufficient to enable Licensors to support a claim for tax
credit with respect to any sum so withheld.  Any tax required to be withheld on
payments by Licensee to Licensors will be an expense of and be borne solely by
Licensors, and Licensee’s royalty payment(s) to Licensors following the
withholding of the tax will be decreased by the amount of such tax
withholding.  Licensee will cooperate with Licensors in the event Licensors
elects to assert, at their own expense, exemption from any tax.

 
12.14  
 Licensee will meet all of the following due diligence requirements:

 
(a)  
Produce a business plan within (**) of the Effective Date and update the
business plan annually;

 
(b)  
Raise (**) Dollars (US$**) in debt, equity or other financing or revenues by the
(**) anniversary of the Effective Date;

 
(c)  
Raise (**)Dollars (US$**) in debt, equity or other financing or revenues by the
(**) anniversary of the Effective Date; and

 
(d)  
Raise (**) Dollars (US$(**)) in debt, equity or other financing or revenues by
the (**) anniversary of the Effective Date.

 
 
-13-

--------------------------------------------------------------------------------

 
 
12.15  
If any one of the due diligence requirements in Section 12.14 is not met, the
license shall terminate pursuant to Section 10.03 and all rights will revert
back to Licensors.

 
12.16  
In the event Licensee (or any entity acting under Licensee’s control or on its
behalf) initiates any proceeding or otherwise asserts any claim challenging the
validity or enforceability of any of the Agreement Patents in any court,
administrative agency or other forum (“Challenge”), the royalty rates set forth
in Section 6.01 and the license maintenance fees set forth in Section 6.03 shall
be automatically (**) on and after the date of such Challenge for the remaining
term of this Agreement. Moreover, to the extent not already covered by Sections
3.01 and 3.02, Licensee agrees to pay all costs and expenses (including actual
attorneys’ fees) incurred by Licensors in connection with defending a Challenge.

 
13. Notices
 
13.01  
Any notice or report required or permitted hereunder shall be given in writing,
and shall be deemed to have been properly given and effective upon delivery, by
registered or certified mail, return receipt requested, or by facsimile with
proof of receipt and a confirmation copy sent by overnight courier, or by
overnight courier, to the following addresses:

 
To Einstein:

Albert Einstein College of Medicine
 of Yeshiva University
1300 Morris Park Avenue
Bronx, New York  10461

Attention:  Office of Biotechnology

With copy to:

Kenneth P. George, Esq.
Amster, Rothstein & Ebenstein, LLP
90 Park Avenue - 21st Floor
New York, New York  10016

To MIT:

Massachusetts Institute of Technology
Technology Licensing Office, Room NE25-230
Five Cambridge Center, Kendall Square
Cambridge, MA 02142-1493
Tel: 
Fax: 
 
Attention: Director

To Cornell

Cornell Center for Technology Enterprise and Commercialization
395 Pine Tree Road, Suite 310
Ithaca, NY 14850
Tel: 
Fax: 
E-Mail: 
 
Attention: Executive Director

 
-14-

--------------------------------------------------------------------------------

 

To IFO

Istituti Fisioterapici Ospitalieri
Via Elio Chianesi
53-00144 Roma, Italy
Tel: 
Fax: 
Email: 

 
Attention: Direzione Generale

To Licensee:

Metastat, Inc.
4 Autumnwood Court
The Woodlands, Texas 77380

Attention:  Warren C. Lau, President and CEO
 
 
IN WITNESS WHEREOF, the parties have entered into this Agreement effective as of
the day and year first above written.
 

    ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, A DIVISION OF
YESHIVA UNIVERSITY       WITNESS:   /s/ J. Michael Gower /s/  T. [Colon]  
Name:  J. Michael Gower Date: October 27, 2010   Title: Vice President and CFO  
  Date: October 27, 2010          
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
      WITNESS:   /s/ Lita Nelson  /s/ Andrea Barry   Name: Lita L. Nelson Date:
September 8, 2010   Title: Director, Technology Licensing Office     Date:
September 8, 2010           CORNELL UNIVERSITY       WITNESS:   /s/ Alan Pacou
 /s/ Danielle [Reelence]   Name: Alan Pacou Date: September 1, 2010   Title:    
Date:  September 1, 2010           ISTITUTI FISIOTERAPICI OSPITALIERI      
WITNESS:   /s/ Francesco Bevere /s/  P. [Cee**]   Name: Francesco Bevere Date:
October 20, 2010   Title: Direttore Generale     Date: October 20, 2010

 
 
-15-

--------------------------------------------------------------------------------

 
 

    METASTAT, INC.       WITNESS:   /s/ Warren C. Lau /s/ Matthew Balk   Name:
Warren C. Lau Date: August 26, 2010   Title: President and CEO     Date:August
26, 2010

 
 
-16-

--------------------------------------------------------------------------------

 

APPENDIX A - Agreement Patents

 
1.
(**);

 
2.
(**);

 
3.
(**);

 
4.
(**); and

 
5.
(**).