Exhibit 10.5

 

THERAVANCE RESPIRATORY COMPANY, LLC

 

LIMITED LIABILITY COMPANY AGREEMENT

 

May 31, 2014

 

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TABLE OF CONTENTS

 

 

 

Page

 

 

 

ARTICLE I DEFINITIONS

 

2

 

1.1

Definitions

 

2

 

 

 

 

 

ARTICLE II FORMATION OF LIMITED LIABILITY COMPANY

 

16

 

2.1

Formation

 

16

 

2.2

Name and Principal Place of Business

 

16

 

2.3

Agreement

 

16

 

2.4

Business

 

17

 

2.5

Definitions

 

17

 

2.6

Term

 

17

 

 

 

 

 

ARTICLE III MEMBERS AND INTERESTS

 

17

 

3.1

Units Generally

 

17

 

3.2

Classes of Units

 

17

 

3.3

Members

 

18

 

3.4

Representations and Warranties

 

18

 

3.5

Resignation or Withdrawal of a Member

 

19

 

3.6

Limited Liability of Members

 

19

 

3.7

General Voting Rights

 

20

 

3.8

Fiduciary Duties of Theravance Biopharma

 

20

 

3.9

Related Party Transactions

 

21

 

3.10

Relationship of Members

 

21

 

3.11

Cancellation of Units

 

21

 

3.12

Compliance with GSK Agreements by Theravance and the LLC

 

22

 

3.13

Performance of Obligations by Manager

 

22

 

3.14

Theravance Triggering Event

 

22

 

 

 

 

 

ARTICLE IV CONTRIBUTIONS TO CAPITAL; WITHDRAWALS; ADVANCES

 

23

 

4.1

Initial Capital Contribution by Theravance

 

23

 

4.2

Additional Capital Contributions

 

25

 

4.3

Interest

 

26

 

4.4

No Right of Withdrawal

 

26

 

4.5

Advances

 

26

 

 

 

 

 

ARTICLE V MANAGEMENT, EXPENSES AND RESTRICTIONS

 

26

 

5.1

Management by Manager; Manager

 

26

 

5.2

Fiduciary Duties of Theravance and the Manager

 

27

 

5.3

Duties of the Manager

 

27

 

5.4

Limitation of Authority of Manager

 

29

 

 

 

 

 

ARTICLE VI NOTICES

 

30

 

6.1

Notices

 

30

 

6.2

Waiver of Notice

 

30

 

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ARTICLE VII OFFICERS

 

30

 

7.1

Officers

 

30

 

7.2

Reliance by Third Parties

 

31

 

7.3

Actions and Determinations of the LLC

 

31

 

 

 

 

 

ARTICLE VIII ACCOUNTING AND RECORDS

 

32

 

8.1

Financial and Tax Reporting

 

32

 

8.2

Members Access to Certain Information

 

32

 

8.3

Books and Records

 

32

 

8.4

Tax Returns

 

32

 

8.5

Tax Matters Partner

 

32

 

8.6

Confidentiality

 

32

 

 

 

 

 

ARTICLE IX CAPITAL ACCOUNTS AND ALLOCATIONS OF NET INCOME AND NET LOSS

 

34

 

9.1

Capital Accounts

 

34

 

9.2

Allocations of Net Income and Net Loss

 

34

 

9.3

Special Allocation Provisions

 

35

 

9.4

Curative Allocations

 

36

 

9.5

Tax Allocations

 

36

 

9.6

Compliance with Section 704(b) of the Code

 

37

 

9.7

Section 754 Election

 

37

 

 

 

 

 

ARTICLE X EXPENSES

 

37

 

10.1

Expenses

 

37

 

 

 

 

 

ARTICLE XI DISTRIBUTIONS

 

37

 

11.1

Distributions

 

37

 

11.2

Tax Distributions

 

37

 

11.3

No Other Withdrawals

 

38

 

11.4

Distribution Limitations

 

38

 

 

 

 

 

ARTICLE XII TRANSFER OF MEMBERSHIP; OTHER MATTERS

 

38

 

12.1

Transfer

 

38

 

12.2

Transfer Void

 

39

 

12.3

Effect of Assignment

 

39

 

12.4

Legends

 

39

 

12.5

Publicly Traded Partnership Limitations

 

40

 

12.6

Effective Date

 

40

 

12.7

Redemption

 

40

 

12.8

Assignment of Reverted Drug Programs

 

40

 

12.9

Admission of Permitted Assignee as a Member

 

41

 

12.10

Transfer to Theravance Biopharma at Effective Time; Admission of Theravance
Biopharma at Effective Time

 

41

 

 

 

 

 

ARTICLE XIII INDEMNIFICATION AND LIMITATION OF LIABILITY

 

41

 

13.1

Indemnification

 

41

 

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13.2

Exculpation

 

42

 

13.3

Limitation of Liability

 

43

 

 

 

 

 

ARTICLE XIV DISSOLUTION AND TERMINATION

 

43

 

14.1

Dissolution

 

43

 

14.2

Authority to Wind Up

 

44

 

14.3

Winding Up and Certificate of Cancellation

 

44

 

14.4

Distribution of Assets

 

44

 

14.5

Contingent Distribution

 

44

 

 

 

 

 

ARTICLE XV MISCELLANEOUS

 

45

 

15.1

Amendment

 

45

 

15.2

Power of Attorney

 

46

 

15.3

Withholding

 

47

 

15.4

Apportionment of Amounts Withheld at the Source or Paid by the LLC

 

47

 

15.5

Notice to and Consent of Members

 

48

 

15.6

Further Assurances

 

48

 

15.7

Binding Effect

 

48

 

15.8

Governing Law

 

48

 

15.9

Title to LLC Property

 

48

 

15.10

Dispute Resolution

 

48

 

15.11

Entire Agreement

 

52

 

15.12

Counterparts

 

52

 

15.13

No State-law Partnership

 

52

 

15.14

Tax Classification

 

52

 

15.15

Severability

 

53

 

15.16

No Third Party Beneficiary

 

53

 

15.17

Interpretation

 

53

 

15.18

Aggregation of Units

 

53

 

EXHIBIT A

Members; Units

EXHIBIT B

Manager; Officers; Tax Matters Member

EXHIBIT C

Assigned Rights and Benefits and Assumed Liabilities

 

ATTACHMENT A

Assigned Assets — Patents

ATTACHMENT B

Assigned Assets — Trademarks

ATTACHMENT C

Assigned Assets — Domain Names

ATTACHMENT D

Assigned Assets — Registrations

ATTACHMENT E

Assumed Liabilities

ATTACHMENT F

FF Chemical Structure

ATTACHMENT G

UMEC Chemical Structure

ATTACHMENT H

VI Chemical Structure

 

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THERAVANCE RESPIRATORY COMPANY, LLC

 

LIMITED LIABILITY COMPANY AGREEMENT

 

This Limited Liability Company Agreement (the “Agreement”) of Theravance
Respiratory Company, LLC (the “LLC”) is entered into pursuant to the Delaware
Limited Liability Company Act, Delaware Code Ann. Title 6, §§18-101, et seq., as
amended from time to time (the “Act”), effective as of May 31, 2014, by and
among (i) each Member (as hereinafter defined) set forth on Exhibit A hereto,
each having duly executed this Agreement or a counterpart to this Agreement
intending to be legally bound by the following terms and conditions,
(ii) Theravance, Inc., a Delaware corporation, as Manager, having duly executed
this Agreement or a counterpart to this Agreement intending to be legally bound
by the following terms and conditions, and (iii) such other Persons who may
hereafter be admitted from time to time as Members (as hereinafter defined) in
accordance with the provisions hereof.

 

RECITALS

 

WHEREAS, Theravance has announced its plan to spin off its drug discovery and
development business into Theravance Biopharma, which will be a separate
publicly traded company;

 

WHEREAS, at the Contribution Time, Theravance will assign to the LLC its
Strategic Alliance Agreement with GSK and all of its rights and obligations
under its Collaboration Agreement with GSK, other than with respect to the
Retained Products, and certain other related assets and liabilities;

 

WHEREAS, immediately after the Contribution Time, Theravance’s Class A Units,
Class B Units and Class C Units of the LLC will entitle it to 100% of the
economic interest in all future payments made by GSK to the LLC under the GSK
Agreements relating to the Assigned Products;

 

WHEREAS, at the Effective Time, Theravance shall transfer all of its Class B
Units in the LLC and six thousand three hundred seventy-five (6,375) of its
Class C Units in the LLC to Theravance Biopharma and Theravance Biopharma shall
be admitted as a Member; and

 

WHEREAS, the LLC shall be controlled by Theravance who shall, among other
things, appoint the Manager which shall manage the business and affairs of the
LLC:

 

NOW, THEREFORE, in consideration of the mutual promises and covenants contained
in this Agreement and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the Members hereby agree as
follows:

 

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ARTICLE I

 

DEFINITIONS

 

1.1                               Definitions.  The following terms shall have
the meanings set forth for purposes of this Agreement:

 

“Accounting Period” shall mean for each Fiscal Year the period beginning on the
1st of January and ending on the 31st of December; provided, however, that the
first Accounting Period commenced on the date of formation of the LLC and shall
end on December 31 of the year of formation of the LLC; and provided, further,
that, at the election of the Manager, a new Accounting Period shall commence on
any date on which an additional Member is admitted to the LLC or a Member ceases
to be a Member for any reason.

 

“Act” shall have the meaning ascribed to it in the Preamble.

 

“Action” shall mean any demand, action, cause of action, suit, countersuit,
arbitration, inquiry, proceeding or investigation by or before any federal,
state, local, foreign or international Governmental Entity or any arbitration or
mediation tribunal.

 

“Affiliates” shall mean, with respect to any specified Person, a Person that
directly or indirectly, through one or more intermediaries, controls, is
controlled by or is under common control with, the Person specified.  For the
avoidance of doubt, as of the Effective Time, GSK is not an Affiliate of
Theravance or Theravance Biopharma.

 

“Agreement” shall mean this Limited Liability Company Agreement of the LLC as
the same shall be amended from time to time.

 

“Alliance Product” shall mean that term as defined in the Strategic Alliance
Agreement.

 

“ANORO™” shall mean the Collaboration Product consisting of (a) the combination
medicine comprising UMEC with VI, with no other therapeutically active
component, and explicitly excluding either component as a monotherapy, and which
is proposed, as of the date hereof, to be sold under the brand name “ANORO™
ELLIPTA™”, and (b) any and all product improvements, additional claims, line
extensions, dosage changes and alternate delivery systems and formulations, in
each case, with respect to only such combination medicine set forth in
subsection (a) comprising UMEC with VI, with no other therapeutically active
component (and explicitly excluding either component as a monotherapy).

 

“Assigned Assets” shall mean:

 

(a)                                 All of Theravance’s rights, title and
interest in and to the patents and patent applications listed in Attachment A,
and any patents of addition, re-examinations, reissues, extensions, granted
supplementary protection certifications, substitutions, confirmations,
registrations, revalidations, revisions, additions and the like, of or to said
patents and any and all divisionals, continuations and continuations-in-part,
and any patents issuing

 

2

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therefrom, as well as any patent applications related thereto and all Actions
against past, present, and future infringement, misappropriation, or other
violation of the foregoing.

 

(b)                                 All of Theravance’s rights, title and
interest in and to the Trademarks listed on Attachment B, together with (i) all
common law rights to such Trademarks, (ii) the goodwill of the LLC Business
symbolized by such Trademarks, (iii) all Actions for, or arising from any
infringement, dilution, unfair competition, or other violation, including past
infringement, dilution, unfair competition, or other violation, of such
Trademarks, and (iv) all rights corresponding thereto throughout the world.

 

(c)                                  All of Theravance’s rights, title and
interest in and to the domain names listed in Attachment C and all Actions
against past, present, and future infringement, misappropriation, or other
violation of the foregoing.

 

(d)                                 All U.S. and foreign copyrights and
copyrightable subject matter related to the LLC Business (and not to the
Theravance Business), whether registered or unregistered, published or
unpublished, statutory or common law, including all related registrations,
applications and common law rights, in any labels, product marketing materials
or other copyrighted works related to the LLC Business and all Actions against
past, present, and future infringement, misappropriation, or other violation of
the foregoing (“LLC Copyrights”).

 

(e)                                  All of Theravance’s rights, title and
interest in and to any Intellectual Property, including trade secrets, not
heretofore described in the definition of Assigned Assets that is reasonably
likely to be used in the LLC Business  (and not in the Theravance Business) and
that Theravance in its sole discretion determines to assign to the LLC.

 

(f)                                   With respect to the Assigned Products, all
(i) regulatory filings and approvals, registrations and governmental
authorizations, (ii) each NDA, (iii) each IND or equivalent, (iv) all compliance
notices, licenses and permits, (v) all applications to the FDA or the comparable
foreign law or bodies in effect or pending at the Effective Time, and (vi) all
materials and information relating to the FDA and other Governmental Approvals
for the LLC Business, all as set forth on Attachment D, and all information
contained therein (collectively, the “Registrations”).

 

(g)                                  All Books and Records.

 

(h)                                 All pre-clinical and clinical data related
to the LLC Business (and not to the Theravance Business) and which is contained
in Theravance’s databases or otherwise in Theravance’s possession or control.

 

(i)                                     All of Theravance’s rights, title and
interest in and to the Clinical Trial Materials to the extent not related to the
Theravance Business.

 

(j)                                    All of Theravance’s rights, title and
interest in and to the Clinical Trial Study Reports to the extent not related to
the Theravance Business.

 

(k)                                 All of Theravance’s rights, title and
interest in and to any and all other assets that primarily relate to the
Assigned Drug Programs or Assigned Products (and not to the

 

3

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Theravance Business) or that otherwise are expressly contemplated by this
Agreement (or the Attachments and Schedules hereto) to be transferred by
Theravance to the LLC.

 

“Assigned Collaboration Product” shall mean each Collaboration Product and any
other compound that has been, is currently or may in the future be developed or
commercialized under the Collaboration Agreement other than Retained Products.

 

“Assigned Drug Programs” shall mean (i) the rights and obligations of Theravance
under the GSK Agreements relating to the Assigned Products, (ii) the Liabilities
of Theravance under the GSK Agreements relating to the Assigned Products and
(iii) the Assigned Assets and Assumed Liabilities.

 

“Assigned Products” shall mean, individually and collectively, each Assigned
Collaboration Product and each Assigned Strategic Alliance Product.

 

“Assigned Strategic Alliance Product” shall mean each Alliance Product and any
other compound that has been, is currently or may in the future be developed or
commercialized under the Strategic Alliance Agreement.

 

“Assignment” shall mean that term as defined in Section 4.1(a).

 

“Assumed Liabilities” shall mean:

 

(a)                                 All Liabilities under the Registrations
arising after the Effective Time.

 

(b)                                 All other Liabilities primarily arising out
of the Assigned Drug Programs or Assigned Products or otherwise arising out of
the conduct of Theravance’s business solely to the extent relating to of the
conduct of the LLC Business or the Assigned Assets.

 

(c)                                  Any and all Liabilities expressly set forth
on Attachment E.

 

(d)                                 Any and all other Liabilities that are
expressly contemplated by this Agreement or any Ancillary Agreement (or the
Attachments and Schedules hereto or thereto) to be transferred to and assumed by
the LLC.

 

“Assumption” shall mean that term as defined in Section 4.1(c).

 

“Books and Records” shall mean books and records of the business, operations and
accounts of an Assigned Product or the LLC to the extent not related to the
Theravance Business.

 

“BREO®/RELVAR®” means (a) the combination medicine comprising FF and VI, with no
other therapeutically active component, and explicitly excluding either
component as a monotherapy, and which is proposed, as of the date hereof, to be
sold under the brand name “BREO® ELLIPTA®” in the United States and
“RELVAR® ELLIPTA®” in the European Union and Japan, and (b) any and all product
improvements, additional claims, line extensions, dosage changes and alternate
delivery systems and formulations, in each case, with respect only to such

 

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combination medicine set forth in subsection (a) comprising FF and VI, with no
other therapeutically active component (and explicitly excluding either
component as a monotherapy).

 

“Business Day” shall mean any day on which banks located in New York, New York
are not required or authorized by law to remain closed.

 

“Capital Account” shall mean, with respect to any Member, the account maintained
for such Member in accordance with the provisions of Section 9.1(a) hereof.

 

“Capital Contribution” shall mean, with respect to any Member, any contribution
to the LLC by such Member of cash or other property.  Any reference in this
Agreement to the Capital Contribution of a Member shall include the Capital
Contribution made by any predecessor holder of the Interest of that Member.

 

“Carrying Value” shall mean:

 

(a)                                 with respect to any LLC asset, the asset’s
adjusted basis for U.S. federal income tax purposes, except as follows:

 

(i)                                     the Carrying Value of any asset
contributed or deemed contributed by a Member to the LLC shall be the fair
market value of such asset at the time of contribution as determined by
agreement of the Members;

 

(ii)                                  the Carrying Value of any asset
distributed or deemed distributed by the LLC to any Member shall be adjusted
immediately prior to such distribution to equal its fair market value at such
time;

 

(iii)                               the Carrying Values of all LLC assets shall
be adjusted to equal their respective fair market values as of the following
times:

 

(1)                                 immediately prior to the date of the
acquisition of any additional Interest by any new or existing Member, other than
in exchange for a de minimis Capital Contribution;

 

(2)                                 immediately prior to the date of the
distribution of more than a de minimis amount of LLC property to a Member;

 

(3)                                 the liquidation of the LLC within the
meaning of Treasury Regulations Section 1.704-1(b)(2)(ii)(g); and

 

(4)                                 in connection with the grant of an Interest
(other than a de minimis interest) as consideration for the provision of
services to or for the benefit of the LLC or a subsidiary of the LLC by an
existing Member acting in a partner capacity, or by a new Member acting in a
partner capacity in anticipation of becoming a Member; provided that an
adjustment described in subclauses (1), (2) and (4) of this clause (iii) shall
be made only if the Manager reasonably determines that such adjustment is
necessary to reflect the collective economic interests of the Members in the
LLC.

 

5

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In the case of any asset that has a Carrying Value determined pursuant to
subclause (1), (2) or (4) above, depreciation or deductions shall be computed
based on the asset’s Carrying Value as so determined, and not on the asset’s
adjusted tax basis, as more fully described under the definition of Net Income
and Net Loss below.

 

(b)                                 with respect to any liability, at a given
time, the amount of such liability to the extent:

 

(i)                                     reflected in the basis of any asset;

 

(ii)                                  previously or currently deductible in
computing Net Income or Net Loss or otherwise for Capital Account maintenance
purposes; or

 

(iii)                               otherwise previously taken into account for
Capital Account maintenance purposes.

 

“Certificate” shall have the meaning ascribed to it in Section 2.1.

 

“Class” shall mean the group of Members owning all of the outstanding Units of a
particular class of Units as set forth in Section 3.2(a) hereof.

 

“Class A Members” shall mean Members holding Class A Units, their permitted
successors and assigns who may be admitted to the LLC as Class A Members, in
accordance with the terms hereof and any other Person who may be admitted to the
LLC as a Class A Member in accordance with the terms of this Agreement.

 

“Class A Units” shall have the meaning ascribed to it in Section 3.2(a).

 

“Class B Members” shall mean Members holding Class B Units, their permitted
successors and assigns who may be admitted to the LLC as Class B Members, in
accordance with the terms hereof and any other Person who may be admitted to the
LLC as a Class B Member in accordance with the terms of this Agreement.

 

“Class B Units” shall have the meaning ascribed to it in Section 3.2(a).

 

“Class C Members” shall mean Members holding Class C Units, their permitted
successors and assigns who may be admitted to the LLC as Class C Members, in
accordance with the terms hereof and any other Person who may be admitted to the
LLC as a Class C Member in accordance with the terms of this Agreement.

 

“Class C Units” shall have the meaning ascribed to it in Section 3.2(a).

 

“Clinical Trial” shall mean a pre-clinical or clinical trial related to the
Assigned Products.

 

“Clinical Trial Materials” shall mean the Assigned Products and the placebo for
each of these products for use in Clinical Trials, whether in bulk, formulated
or finished form and whether in existence at the Effective Time.

 

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“Clinical Trial Study Reports” shall mean all reports or summaries of all data,
records and documents resulting from the Clinical Trials.

 

“Code” shall mean the Internal Revenue Code of 1986, as amended.

 

“Collaboration Agreement” means that certain Collaboration Agreement, dated as
of November 14, 2002, by and between Theravance and GSK, including all
amendments and supplements thereto (including the Theravance Collaboration
Agreement Amendment dated March 3, 2014 (the “Collaboration Amendment
Agreement”)).

 

“Collaboration Product” shall mean that term as defined in the Collaboration
Agreement.

 

“Consents” shall mean any and all consents, waivers or approvals from, or
notification requirements to, any Third Parties.

 

“Contingent Distribution” shall have the meaning ascribed to it in Section 14.5.

 

“Contribution Time” shall mean 11:59 p.m. Pacific Daylight Time on May 31, 2014.

 

“Costs” shall mean LLC Costs and Management Costs.

 

“Defined Covenants” shall mean any covenant:

 

(a)                                 requiring Theravance Biopharma and its
permitted transferees, successors and permitted assigns (as applicable) to fully
perform and comply with the Master Agreement and this Agreement and prohibiting
any of them from taking any action, or failing to take any action, that
breaches, violates or could reasonably be expected to breach or violate the
Master Agreement or this Agreement;

 

(b)                                 (A) requiring Theravance Biopharma and its
permitted transferees, successors and permitted assigns (as applicable) to
enforce the Master Agreement and this Agreement and their rights thereunder and
hereunder, in each case to the extent that the failure to do so under this
clause (A) would be reasonably expected to have a direct or indirect material
and adverse effect on Theravance Biopharma’s or its permitted transferees’,
successors’ and permitted assigns’ (as applicable) rights or obligations under
the Master Agreement or this Agreement, and (B) prohibiting Theravance Biopharma
and its permitted transferees, successors and permitted assigns (as applicable)
from amending, modifying, supplementing, waiving, canceling, terminating or
granting any consent thereunder or hereunder, or taking any other action or
failing to take any action having the effect of the foregoing, or agreeing to do
any of the foregoing directly or indirectly, in whole or in part, to the Master
Agreement or this Agreement or any rights thereunder or hereunder, in each case
to the extent that such action or inaction referred to in clause (B) would be
reasonably expected to have a direct or indirect material and adverse effect on
Theravance Biopharma’s or its permitted transferees’, successors’ and permitted
assigns’ (as applicable) rights or obligations under the Master Agreement or
this Agreement;

 

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(c)                                  prohibiting Theravance Biopharma and its
permitted transferees, successors and permitted assigns (as applicable) from
taking any action to, directly or indirectly, adversely impact, delay, forgive,
release or compromise any amount owed to or becoming owing to them under this
Agreement; and

 

(d)                                 requiring a holder to maintain its separate
existence from any other entity and to operate in a manner so as to establish or
maintain a bankruptcy remote status, including by restricting incurrence of
debt, grant of liens, employment of employees and consultants, ownership or
lease of real or personal property, guarantees, incurrence of liabilities,
issuance of securities, lines of business, and initiation of bankruptcy or
insolvency proceedings and other similar customary covenants regarding
bankruptcy remote status.

 

“DGCL” shall mean the General Corporation Law of the State of Delaware, 8 Del.
Code § 101 et seq., as amended from time to time.

 

“Designated Jurisdiction” shall mean California.

 

“Distribution Date” shall mean that term as defined in the Separation and
Distribution Agreement.

 

“Effective Time” shall mean 12:01 a.m. Pacific Daylight Time on June 1, 2014.

 

“Electronic Signature” shall have the meaning ascribed to it in Section 15.12.

 

“Estimated Tax Period” shall mean, for each Fiscal Year, the periods of
January 1 through March 31, April 1 through May 31, June 1 through August 31,
and September 1 through December 31 (each a “Fiscal Quarter”).

 

“FF” shall mean the inhaled corticosteroid known as Fluticasone Furorate (with
the chemical structure as set forth in Attachment F) or an ester, salt or other
noncovalent derivative thereof.

 

“Financial Plan” shall have the meaning ascribed to it in Section 5.3(e).

 

“Fiscal Year” shall mean the taxable year of the LLC, which shall be the period
from January 1 to December 31 of each year, except as otherwise required by the
Code.

 

“GAAP” shall mean United States generally accepted accounting principles.

 

“Governmental Approvals” shall mean any notices, reports or other filings to be
made, or any consents, registrations, approvals, permits or authorizations to be
obtained from, any Governmental Entity.

 

“Governmental Entity” shall mean any federal, state, local, foreign or
international court government department, commission, board, bureau, agency,
official or other regulatory, administrative or governmental entity.

 

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“GSK” shall mean Glaxo Group Limited, a private company limited by shares
registered under the laws of England and Wales.

 

“GSK Agreements” shall mean the Collaboration Agreement and the Strategic
Alliance Agreement, individually or collectively.

 

“IND” shall mean an investigational new drug application, including any
amendments and supplements thereto, and all reports, correspondence and other
submissions related thereto.

 

“Indebtedness” shall mean as to any Person: (a) all obligations, whether or not
contingent, of such Person for borrowed money (including, without limitation,
reimbursement and all other obligations with respect to surety bonds, letters of
credit and bankers’ acceptances, whether or not matured); (b) all obligations of
such Person evidenced by notes, bonds, debentures or similar instruments;
(c) all obligations of such Person under leases which have been or should be, in
accordance with GAAP, recorded as capital leases; (d) all liabilities and
obligations secured by any Lien on any property or asset owned or held by that
Person regardless of whether the indebtedness secured thereby shall have been
assumed by that Person or is non-recourse to the credit of that Person; and
(e) all Indebtedness of any other Person referred to in clauses (a) through
(e) above, guaranteed, directly or indirectly, by that Person; but excluding all
obligations of such Person for deferred rent.

 

“Intellectual Property” shall mean all intellectual property and industrial
property rights of any kind or nature, including all United States and foreign
(a) patents, patent applications, patent disclosures, and all related
continuations, continuations-in-part, divisionals, reissues, re-examinations,
substitutions and extensions thereof, (b) Trademarks and all goodwill associated
therewith, (c) copyrights and copyrightable subject matter, whether statutory or
common law, registered or unregistered and published or unpublished, (d) rights
of publicity, (e) moral rights and rights of attribution and integrity,
(f) rights in Software, (g) trade secrets and all other confidential and
proprietary information, know-how, inventions, improvements, processes,
formulae, models and methodologies, (h) rights to domain names, (i) rights to
personal information, (j) telephone numbers and internet protocol addresses,
(k) applications and registrations for the foregoing, and (l) Actions against
past, present, and future infringement, misappropriation, or other violation of
the foregoing (and rights to bring such Actions).

 

“Interest” shall mean the interest of a Member (or a permitted assignee of a
Member) in the LLC, which is represented by the Units held by such Member (or
permitted assignee), and includes all of the respective rights and
responsibilities appurtenant thereto hereunder, including (i) with respect to a
Member (but not an assignee), the right, if any, to vote, (ii) the right to have
a Capital Account maintained for such Member (or assignee), (iii) the right to
receive allocations of Net Income and Net Losses pursuant to Article IX,
(iv) the right to receive distributions of cash or property of the LLC, (v) the
right to appoint the Manager, if applicable and (vi) the right to approve the
actions prohibited by Section 5.4, if applicable.

 

“Interim Period” shall mean, upon the Transfer of a Member’s Interest (other
than the Theravance Biopharma Transfer or the R&D Transfer), a change in the LLC
Percentage of any Member, the resignation of a Member from the LLC or the
admission of a new Member

 

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to the LLC (other than the admission of Theravance Biopharma as a Member
pursuant to Section 12.10 or the R&D Transfer), in each case, other than on the
first day of any Fiscal Year, or, upon the election of the Manager, the period
beginning on the date of such event or election and ending on the last day of
the Fiscal Year in which such Interim Period began or on the day immediately
preceding the beginning of a new Interim Period, whichever is earlier.

 

“Law” shall mean any constitutional provision, law, statute, rule, regulation
(including any stock exchange rule or regulation), ordinance, treaty, order,
decree, license, permit, policy, guideline, consent, approval, certificate,
judgment or decision of any governmental authority or any judgment, decree,
injunction, writ, order or like action of any court or other judicial or
quasi-judicial tribunal.

 

“Liabilities” shall mean any and all debts, liabilities, and obligations,
whether accrued or fixed, known or unknown, absolute or contingent, matured or
unmatured, reserved or unreserved, or determined or determinable of any kind or
nature whatsoever, including those arising under any Law or Action, whether
asserted or unasserted, or order, writ, judgment, injunction, decree,
stipulation, determination or award entered by or with any governmental entity,
and those arising under any Contract or any fines, damages or equitable relief
which may be imposed in connection with any of the foregoing and including all
costs and expenses related thereto.

 

“Lien” shall mean any mortgage, deed of trust, pledge, hypothecation,
assignment, encumbrance, lien (statutory or other) or other security interest of
any kind or nature whatsoever, including, without limitation, those created by,
arising under or evidenced by any conditional sale or other title retention
contract, the interest of a lessor under a lease which in accordance with GAAP
should be recorded as a capital lease, or any financing lease having
substantially the same economic effect as any of the foregoing.

 

“LLC” shall have the meaning ascribed to it in the Preamble.

 

“LLC Business” shall mean exercising all of the rights and benefits and
performing and discharging all of the liabilities and obligations under (i) the
Strategic Alliance Agreement and (ii) the Collaboration Agreement relating to
the Assigned Collaboration Products.

 

“LLC Costs” shall mean all costs and expenses incurred by or on behalf of the
LLC relating to the operation of the LLC, whether recurring or non-recurring,
including, without limitation, (i) occupancy costs, (ii) personnel costs of the
LLC, (iii) general administrative costs of the LLC, including service costs (if
any) from Theravance for services provided to the LLC, and (iv) costs of
indemnifying the Manager.

 

“LLC Percentage” shall mean, as of any date, the LLC Percentage for each Member
(or assignee of such Member), which shall be determined by dividing the number
of Units of such Member (or assignee) in the LLC as of such date by the sum of
total issued and outstanding Units in the LLC as of such date (including, for
the avoidance of doubt, all Class A Units, all Class B Units and all Class C
Units).  The sum of the Members’ (and assignees of Members’) LLC Percentages
shall be one hundred percent (100%).

 

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“Majority in Interest of the Class A Members” shall mean, as of any date, unless
otherwise expressly set forth herein, the Member(s) holding at least a majority
of the outstanding Class A Units as of such date.

 

“Majority in Interest of the Class B Members” shall mean, as of any date, unless
otherwise expressly set forth herein, the Member(s) holding at least a majority
of the outstanding Class B Units as of such date.

 

“Majority in Interest of the Class C Members” shall mean, as of any date, unless
otherwise expressly set forth herein, the Member(s) holding at least a majority
of the outstanding Class C Units as of such date.

 

“Management Fee” shall mean the management fee payable to the Manager on a
quarterly basis pursuant to Section 5.5.

 

“Manager” means the Person appointed pursuant to Section 5.1 to manage the
business and affairs of the LLC or, if no Person is appointed as Manager
pursuant to Section 5.1, a Majority in Interest of the Class A Members.

 

“Master Agreement” means that certain Master Agreement, dated March 3, 2014, by
and among GSK, Theravance and Theravance Biopharma, as amended from time to
time.

 

“Members” and “Member” means the Persons listed as members on Exhibit A (as may
be amended from time to time) and any other Person that both acquires an
Interest and is admitted to the LLC as a Member in accordance with the terms of
this Agreement, in such Person’s capacity as a member of the LLC.

 

“NDA” shall mean a new drug application, including any amendments or supplements
thereto, and all reports, correspondence and other submissions related thereto.

 

“Net Cash” shall mean an amount of cash at the end of each Fiscal Quarter (and
Interim Period, if applicable) equal to (i) the amount of cash and cash
equivalents held by the LLC as of the end of such Fiscal Quarter (or Interim
Period, if applicable) minus (ii) the cash, if any, expected to be used in the
LLC over the next four Fiscal Quarters.

 

“Net Income” and “Net Loss” shall mean, for each Accounting Period, an amount
equal to the LLC’s net taxable income or loss, as applicable, for such
Accounting Period, determined in accordance with Code Section 703(a) (it being
understood that for this purpose, all items of income, gain, loss or deduction
required to be stated separately pursuant to Section 703(a)(1) of the Code shall
be included in such taxable income or loss) and determined in accordance with
the accounting method used by the LLC for U.S. Federal income tax purposes with
the following adjustments (without duplication):

 

(a)                                 all items of income, gain, loss or deduction
specifically allocated pursuant to Section 9.3 shall not be taken into account
in computing such taxable income or loss;

 

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(b)                                 any income of the LLC that is exempt from
U.S. Federal income taxation and not otherwise taken into account in computing
Net Income and Net Loss shall be added to such taxable income or loss;

 

(c)                                  if the Carrying Value of any asset differs
from its adjusted tax basis for U.S. Federal income tax purposes, any gain or
loss resulting from a disposition of such asset shall be calculated with
reference to such Carrying Value;

 

(d)                                 upon an adjustment to the Carrying Value of
any asset pursuant to clauses (ii) or (iii) of subsection (a) of the definition
of Carrying Value (other than an adjustment in respect of depreciation), the
amount of the adjustment shall be included as gain or loss in computing such
taxable income or loss;

 

(e)                                  if the Carrying Value of any asset differs
from its adjusted tax basis for U.S. Federal income tax purposes the amount of
depreciation, amortization or cost recovery deductions with respect to such
asset for purposes of determining Net Income and Net Loss shall be an amount
which bears the same ratio to such Carrying Value as the U.S. Federal income tax
depreciation, amortization or other cost recovery deductions bears to such
adjusted tax basis (provided that if the U.S. Federal income tax depreciation,
amortization or other cost recovery deduction is zero, the Manager may use any
reasonable method for purposes of determining depreciation, amortization or
other cost recovery deductions in calculating Net Income and Net Loss; and

 

(f)                                   except for items set forth in clauses
(a) through (e) above, any expenditures of the LLC not deductible in computing
taxable income or loss, not properly capitalizable and not otherwise taken into
account in computing Net Income and Net Loss pursuant to this definition shall
be treated as deductible items.

 

For the avoidance of doubt, costs and expenses of the LLC shall not include
Management Costs that are borne by the Manager.

 

“Non-Contributing Member” shall have the meaning ascribed to it in Section 4.2.

 

“Nonrecourse Deductions” shall be as defined in Treasury Regulations
Section 1.704-2(b).  The amount of Partner Nonrecourse Deductions for a Fiscal
Year equals the net increase, if any, in the amount of Partnership Minimum Gain
during that Fiscal Year, determined according to the provisions of Treasury
Regulations Section 1.704-2(c).

 

“Officer” shall have the meaning ascribed to it in Section 7.1.

 

“Partner Nonrecourse Debt Minimum Gain” shall mean an amount with respect to
each partner nonrecourse debt (as defined in Treasury Regulations
Section 1.704-2(b)(4)) equal to the Partnership Minimum Gain that would result
if such partner nonrecourse debt were treated as a nonrecourse liability (as
defined in Treasury Regulations Section 1.752-1(a)(2)) determined in accordance
with Treasury Regulations Section 1.704-2(i)(3).

 

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“Partner Nonrecourse Deductions” shall be as defined in U.S. Treasury
Regulations Section 1.704-2(i)(2).

 

“Partnership Minimum Gain” shall be as defined in Treasury Regulations
Section 1.704-2(b)(2) and 1.704-2(d).

 

“Permitted Consultants” shall have the meaning ascribed to it in the Master
Agreement.

 

“Person” shall mean a natural person, partnership (whether general or limited
and whether domestic or foreign), limited liability company, foreign limited
liability company, trust, estate, association, corporation, government entity,
custodian, nominee or any other individual or entity in its own or
representative capacity.

 

“Projected Capital Contribution” for the LLC shall mean an amount calculated
each Fiscal Quarter equal to the forecast negative net cash flow of the LLC for
that Fiscal Quarter, as set forth in the Operating Plan then in effect for such
Fiscal Quarter.

 

“Proprietary Information” shall have the meaning ascribed to it in Section 8.6.

 

“R&D Transfer” shall mean the contemplated Transfer on or about June 1, 2014 of
Theravance Biopharma’s Interests to Theravance Biopharma R&D, Inc., a
wholly-owned subsidiary of Theravance Biopharma.

 

“Restricted Party” means any of Almirall, AstraZeneca, Boehringer Ingelheim,
Chiesi, Forest Laboratories, Merck, Mylan, Novartis, Sandoz, Teva, Theravance
Biopharma and any other pharmaceutical or biotechnology company with a product
either being developed or commercialized for the treatment of respiratory
disease, and their respective Restricted Party Affiliates.

 

“Restricted Party Affiliate” with respect to any person means any other person,
whether de jure or de facto, which directly or indirectly controls, is
controlled by, or is under common control with such person for so long as such
control exists, where “control” means the decision-making authority as to such
other person and, further, where such control shall be presumed to exist where
such other person owns more than fifty percent (50%) of the equity (or such
lesser percentage which is the maximum allowed to be owned by a foreign
corporation in a particular jurisdiction) having the power to vote on or direct
the affairs of the entity.

 

“Retained Product” means each of ANORO™, BREO®/RELVAR® and VI Monotherapy.

 

“SEC” shall mean the U.S. Securities and Exchange Commission.

 

“Securities Act” shall mean the Securities Act of 1933, as amended from time to
time, and the rules and regulations thereunder.

 

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“Securities Exchange Act” shall mean the United States Securities Exchange Act
of 1934, as then in effect and as thereafter amended from time to time, or any
successor statute, including the rules and regulations promulgated thereunder.

 

“Separation and Distribution Agreement” shall mean the Separation and
Distribution Agreement between Theravance and Theravance Biopharma dated as of
June 1, 2014.

 

“Strategic Alliance Agreement” shall mean that certain Strategic Alliance
Agreement, dated as of March 30, 2004, by and between Theravance and GSK,
including all amendments and supplements thereto (including the Theravance
Strategic Alliance Agreement Amendment dated March 3, 2014 (the “Strategic
Alliance Amendment Agreement”).

 

“Tax Matters Partner” shall have the meaning ascribed to it in Section 8.5.

 

“Theravance” shall mean Theravance, Inc., a Delaware corporation, its successors
and/or permitted assigns.

 

“Theravance Affiliate” shall mean an “Affiliate” (as such term is defined in the
GSK Agreements) of Theravance.

 

“Theravance Biopharma” shall mean Theravance Biopharma, Inc., a Cayman Islands
exempted company, its successors and/or permitted assigns.

 

“Theravance Biopharma Transfer” shall mean the Transfer of all Class B Units and
six thousand three hundred seventy-five (6,375) Class C Units to Theravance
Biopharma pursuant to Section 12.10.

 

“Theravance Biopharma Triggering Event” shall mean the Transfer to GSK and/or
its Affiliates, in one or more transactions, of a Majority in Interest of the
Class B Units, which, for the avoidance of doubt, shall include (a) any
transaction or series of related transactions (including mergers, consolidations
and other forms of business consolidations) following which GSK and/or its
Affiliates own at least 50% of the outstanding equity securities of Theravance
Biopharma, the entity surviving such transaction or any direct or indirect
parent entity of such continuing or surviving entity at a time when Theravance
Biopharma or such entity surviving such transaction or any such direct or
indirect parent entity of such continuing or surviving entity or any of its
subsidiaries holds a Majority in Interest of the Class B Units; or (b) the sale,
lease, license, transfer or disposal of all or substantially all of the business
or assets  of Theravance Biopharma to GSK and/or its Affiliates provided that
following such transaction GSK and/or its Affiliates hold a Majority in Interest
of the Class B Units.

 

“Theravance Business” shall mean any business within (i) the “ParentCo Business”
as defined in the Separation and Distribution Agreement (other than the portion
thereof that is specific to the Assigned Products) or (ii) the “SpinCo Business”
as defined in the Separation and Distribution Agreement.

 

“Theravance Triggering Event” shall mean: (a) any transaction or series of
related transactions (including mergers, consolidations and other forms of
business

 

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consolidations) following which GSK and/or its Affiliates own at least 50% of
the outstanding equity securities of Theravance, the entity surviving such
transaction or any direct or indirect parent entity of such continuing or
surviving entity; (b) the sale, lease, license, transfer or other disposal of
all or substantially all of the business or assets of Theravance to GSK and/or
its Affiliates; (c) the assignment by Theravance or its Affiliate to GSK or its
Affiliate of all or substantially all of its rights and obligations under the
Collaboration Agreement or the Strategic Alliance Agreement; (d) the Transfer to
GSK and/or its Affiliates of a Majority in Interest of the Class A Units; or
(e) the occurrence of (1) the breach or violation by Theravance of the GSK
Agreements or the taking of other action by Theravance, in each case, that gives
GSK the right to terminate or invalidate the GSK Agreements or the terms thereof
relating to the Assigned Drug Programs and (2) the termination or invalidation
of the GSK Agreements or the terms thereof relating to the Assigned Drug
Programs by GSK.

 

“Theravance Triggering Event Date Agreements” shall have the meaning ascribed to
it in Section 3.14.

 

“Third Party” shall mean any Person other than Theravance, any Theravance
Affiliate, the LLC and any LLC Affiliate.

 

“Transfer” shall mean transfer, sell, mortgage, pledge, assign or otherwise
dispose of, either directly or indirectly, by operation of law or otherwise. 
For the avoidance of doubt, (i) the grant of Defined Covenants by Theravance
Biopharma and its permitted transferees, successors and permitted assigns (as
applicable) with respect to the Master Agreement, this Agreement or the Class B
Units or Class C Units in connection with any monetization of any Interest in
its Class B Units or Class C Units, and the grant of “Pre-Agreed Covenants” (as
defined in the Master Agreement) in compliance with the Master Agreement shall
not constitute a Transfer under this Agreement; and (ii) the parties expressly
agree that no inference shall be drawn as to whether any other grant of any
covenants constitutes an assignment under any GSK Agreement or a Transfer under
this Agreement from the fact of the agreements with respect to Defined Covenants
and Pre-Agreed Covenants.  Notwithstanding the foregoing, Theravance Biopharma
(on behalf of itself and its permitted transferees, successors and permitted
assigns) agrees that, as a condition to the granting of any Defined Covenants: 
(i)  Theravance Biopharma and/or its permitted transferees, successors or
permitted assigns (as applicable) shall obtain a certification from the original
third party recipient of such Defined Covenants, as applicable, that it is not a
Restricted Party (as defined above); and (ii) any notes, securities or other
instruments subject to such covenants shall provide that (a) they may not be
held by a Restricted Party and if, notwithstanding such prohibition, such notes,
securities or other instruments come to be held by a Restricted Party, such
Restricted Party shall not be entitled to enforce or vote to enforce such
Defined Covenants, (b) any holder of such notes, securities or other instruments
seeking to enforce or to vote to enforce such Defined Covenants must provide a
certificate for the benefit of the issuer that such holder is not a Restricted
Party, and (c) the restriction set forth in the preceding sections (a) and
(b) and this section (c) may not be waived or amended.  Any notes, securities or
other instruments subject to such Defined Covenants issued in physical form
shall bear a legend referencing the provisions set forth in (a), (b) and (c) of
the foregoing sentence.

 

“Treasury Regulations” shall mean regulations issued pursuant to the Code.

 

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“UMEC” shall mean the long-acting muscarinic antagonist umeclidinium bromide
(with the chemical structure as set forth in Attachment G) or an ester, salt or
other non-covalent derivative thereof.

 

“Units” shall mean the Class A Units, the Class B Units and the Class C Units.

 

“VI” shall mean the long-acting beta2 agonist vilanterol (with the chemical
structure as set forth in Attachment H) or an ester, salt or other noncovalent
derivative thereof.

 

“VI Monotherapy” shall mean (a) VI, solely as a monotherapy (i.e., excluding VI
in combination with any one or more other therapeutically active component(s)),
and (b) any and all product improvements, additional claims, line extensions,
dosage changes and alternate delivery systems, in each case, with respect to
only VI solely as a monotherapy (i.e., excluding VI in combination with any one
or more other therapeutically active component(s)).

 

ARTICLE II

 

FORMATION OF LIMITED LIABILITY COMPANY

 

2.1                               Formation.  The LLC has been formed as a
Delaware limited liability company by the execution and filing with the
Secretary of State of the State of Delaware of a Certificate of Formation (as
the same may be amended from time to time, the “Certificate”).  Upon such
filing, the powers of such authorized person ceased.  The rights, powers,
duties, obligations and liabilities of the Members (in their respective
capacities as such) shall be determined pursuant to the Act and this Agreement. 
To the extent that the rights, powers, duties, obligations and liabilities of
any Member (in its capacity as such) are different by reason of any provision of
this Agreement than they would be in the absence of such provision, this
Agreement shall, to the extent permitted by the Act, control.  The Members
hereby ratify the actions of the authorized person of the LLC in executing and
filing the Certificate with the Secretary of State of the State of Delaware. 
Other than actions relative to its formation, the LLC has not engaged in any
business or conducted any other activities prior to the date of this Agreement.

 

2.2                               Name and Principal Place of Business.  Unless
and until amended in accordance with this Agreement and the Act, the name of the
LLC will be “Theravance Respiratory Company, LLC.”  The principal place of
business of the LLC shall initially be located at 901 Gateway Blvd., South San
Francisco, CA 94080, or such other location as the Manager may, from time to
time, designate.  The address of the LLC’s registered office in the State of
Delaware, and the name of the registered agent for service of process, shall be
The Corporation Trust Company, Corporation Trust Center, 1209 Orange Street,
Wilmington, Delaware 19801, or such other place or person in the State of
Delaware as the Manager shall designate.

 

2.3                               Agreement.  For and in consideration of the
mutual covenants herein contained and for other good and valuable consideration,
the receipt and sufficiency of which is hereby acknowledged, the Members
executing this Agreement hereby agree to the terms and conditions of this
Agreement, as it may from time to time be amended in accordance with this
Agreement.  It is the express intention of the parties hereto that this
Agreement shall be the sole statement of agreement among them, and, except to
the extent a provision of this Agreement expressly

 

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incorporates federal income tax rules by reference to sections of the Code or
Treasury Regulations or is expressly prohibited or ineffective under the Act,
this Agreement shall govern even when inconsistent with or different from the
provisions of the Act or any other law or rule.  To the extent any provision of
this Agreement is prohibited or ineffective under the Act or other applicable
law, this Agreement shall be considered amended to the smallest degree possible
in order to make this Agreement effective under the Act or such other applicable
law.  In the event the Act is subsequently amended or interpreted in such a way
to make valid any provision of this Agreement that was formerly invalid, such
provision shall be considered to be a part of this Agreement from and after the
date of such interpretation or amendment.

 

2.4                               Business.  The purpose of the LLC is to
(i) engage in the LLC Business, (ii) enter into, make, and perform all contracts
and other undertakings relating thereto or arising therefrom, (iii) carry on any
other business or activity relating thereto or arising therefrom and (iv) carry
on anything incidental, convenient or necessary to the foregoing. 
Notwithstanding the foregoing, the LLC may engage in any lawful business
permitted under the Act or the laws of any jurisdiction in which the LLC may do
business.

 

2.5                               Definitions.  Terms not otherwise defined in
this Agreement shall have the meanings set forth in Article I.

 

2.6                               Term.  The term of the LLC commenced on the
date the Certificate was filed with the Secretary of State of the State of
Delaware in accordance with the Act and shall continue until the LLC is
dissolved pursuant to Article XIV of this Agreement.

 

ARTICLE III

 

MEMBERS AND INTERESTS

 

3.1                               Units Generally.

 

(a)                                 Generally.  The Interest of each of the
Members in the LLC shall consist of a number of “Units.”  Except as otherwise
provided in this Agreement or the Act, the holders of each class of Units shall
be entitled to the rights, subject to the obligations set forth herein, ascribed
to such class of Units.  The Units shall be uncertificated unless the Manager
determines that the Units shall be represented by certificates in such form as
shall be determined by the Manager from time to time.  If applicable, the LLC
may issue a new certificate in place of any certificate therefore issued by it,
alleged to have been lost, stolen or destroyed, and the LLC may require the
owner of the lost, stolen or destroyed certificate, or his or her legal
representative to give the LLC a bond sufficient to indemnify it against any
claim that may be made against it on account of that alleged loss, theft or
destruction of any such certificate or the issuance of such new certificate.

 

3.2                               Classes of Units. There are three classes of
Units designated “Class A Units” (the “Class A Units”), “Class B Units” (the
“Class B Units”) and “Class C Units” (the “Class C Units”).  Subject to the
terms and conditions of Articles III and IV hereof, the LLC is authorized to
issue up to ten thousand (10,000) Units in the aggregate, divided as follows: 
(i) seven hundred fifty (750) Units shall be Class A Units, of which seven
hundred fifty (750) Class A Units shall

 

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be issued and outstanding and owned by the Class A Members as of the
Contribution Time, (ii) two thousand one hundred twenty-five (2,125) Units shall
be Class B Units, of which two thousand one hundred twenty-five (2,125) Class B
Units shall be issued and outstanding and owned by the Class B Members as of the
Contribution Time, and (iii) seven thousand one hundred twenty-five (7,125)
Units shall be Class C Units, of which seven thousand one hundred twenty-five
(7,125) Class C Units shall be issued and outstanding and owned by the Class C
Members as of the Contribution Time.  The parties hereto agree that,
notwithstanding anything to the contrary in this Agreement, the LLC is not and
shall not be authorized to issue additional classes of Units or additional
Class A, Class B or Class C Units, other than those authorized and issued
pursuant to the preceding sentence.  Each Class A Member shall hold an Interest
in the LLC represented by the Class A Units set forth opposite the Member’s name
on Exhibit A, as amended from time to time pursuant to Section 15.1(c), each
Class B Member shall hold an Interest in the LLC represented by the Class B
Units set forth opposite the Member’s name on Exhibit A (after giving effect to
the Theravance Biopharma Transfer pursuant to Section 12.10), as amended from
time to time pursuant to Section 15.1(c), and each Class C Member shall hold an
Interest in the LLC represented by the Class C Units set forth opposite the
Member’s name on Exhibit A (after giving effect to the Theravance Biopharma
Transfer pursuant to Section 12.10), as amended from time to time pursuant to
Section 15.1(c).  For the avoidance of doubt each Member may hold more than one
class of Units.  Each Member holding Units shall have (a) the right to share in
the Net Income and Net Loss of the LLC as provided in this Agreement, (b) a
right to the Capital Account maintained for such Member according to Article IX
hereof, (c) the right to receive distributions from the LLC as provided in this
Agreement, and (d) such other relative rights, powers and duties as are set
forth in this Agreement.

 

3.3                               Members.  The Members of the LLC are set forth
on Exhibit A attached hereto, each of whom is (or, in the case of Theravance
Biopharma, will be as of the Effective Time) admitted to the LLC as a Member as
of the Contribution Time, in the case of Theravance, and as of the Effective
Time, in the case of Theravance Biopharma.  The name and place of residence of
each Member is as set forth on Exhibit A attached hereto (after giving effect to
the Theravance Biopharma Transfer pursuant to Section 12.10), as amended from
time to time pursuant to Section 15.1(c).  Each Member shall be entitled to
review Exhibit A.

 

3.4                               Representations and Warranties.  Each Member
hereby represents and warrants to the LLC and each other Member as follows:

 

(a)                                 Good Standing; Due Organization.  If such
Member is a Person who is not an individual, such Member is duly organized,
validly existing, and in good standing under the law of its state of
organization and has full organizational power to execute and deliver this
Agreement and to perform its obligations hereunder.

 

(b)                                 Accredited Investor.  (i) Such Member is an
“accredited investor” as that term is defined in Rule 501(a) of Regulation D of
the Securities Act, or (ii) such Member is acquiring the respective Interest in
compliance with Federal, state, local or foreign laws.

 

(c)                                  Purchase Entirely for Own Account.  Except,
with respect to Theravance Biopharma, for the R&D Transfer, the Member is
acquiring its Interest for the Member’s own account for investment purposes only
and not with a view to or for the resale, distribution,

 

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subdivision or fractionalization thereof, and has no contract, understanding,
undertaking, agreement or arrangement of any kind with any Person to Transfer to
any Person its Interest or any part thereof, nor does such Member have any plans
to enter into any such agreement.

 

(d)                                 Investment Experience.  By reason of the
Member’s business or financial experience, the Member has the knowledge,
experience and capacity to evaluate and protect its own interests in connection
with the transactions contemplated hereunder, is able to bear the economic and
financial risks of an investment in the LLC for an indefinite period of time,
and at the present time could afford a complete loss of such investment.

 

(e)                                  Disclosure of Information.  The Member is
aware of the LLC’s business affairs and financial condition and has acquired
sufficient information about the LLC to reach an informed and knowledgeable
decision to acquire an Interest.

 

(f)                                   Federal and State Securities Laws. 
Assuming federal and state securities laws apply to the interests described
herein, the Member acknowledges that the Units have not been registered under
the Securities Act or any state securities laws, inasmuch as they are being
acquired in a transaction not involving a public offering, and, under such laws,
may not be resold or transferred by the Member without appropriate registration
or the availability of an exemption from such requirements.  In this connection,
the Member represents that it is familiar with SEC Rule 144, as presently in
effect, and understands the resale limitations imposed thereby and by the
Securities Act.

 

(g)                                  DISCLAIMER. THE ASSIGNED ASSETS AND ANY
LICENSES ARE PROVIDED “AS IS” WITH NO WARRANTY EXPRESS OR IMPLIED OR
STATUTORY, INCLUDING, WITHOUT LIMITATION, WARRANTIES OF MERCHANTABILITY, FITNESS
FOR ANY PARTICULAR PURPOSE, NONINFRINGEMENT, TITLE, VALIDITY OR OTHERWISE.

 

3.5                               Resignation or Withdrawal of a Member.  Except
as specifically provided herein, and subject to the provisions for Transfers
contained in Article XII, no Member shall have the right to resign or withdraw
from membership in the LLC or withdraw its Interest.

 

3.6                               Limited Liability of Members.

 

(a)                                 General.  Except as expressly provided in
the Act, (i) no Member or any of its Affiliates shall have any liability for the
debts, obligations or liabilities of the LLC, any other Member or their
respective Affiliates solely by reason of being a Member or an Affiliate of a
Member, (ii) the debts, obligations and liabilities of the LLC, whether arising
in contract, tort or otherwise, shall be solely the debts, obligations and
liabilities of the LLC, and (iii) no Member or former Member shall be obligated
personally for any such debt, obligation or liability of the LLC solely by
reason of being a Member or former Member.

 

(b)                                 Deficit Capital Accounts.  Notwithstanding
anything to the contrary contained in this Agreement, and notwithstanding any
custom or rule of law to the contrary, to the extent that there exists a deficit
in the Capital Account of any Member, upon dissolution of the LLC such deficit
shall not be an asset of the LLC and such Members shall not be obligated to

 

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contribute such amount to the LLC to bring the balance of such Member’s Capital
Account to zero.

 

3.7                               General Voting Rights.  The Class A Members
shall, and the Class B Members and the Class C Members shall not, be entitled to
vote, approve, consent or authorize on all matters for which the vote, approval,
consent or authorization of the Members is required or permitted under this
Agreement or the Act.  Each Class A Member shall have one (1) vote for each
Class A Unit held by it. For the avoidance of doubt, Class B Members and Class C
Members shall not be entitled to vote, approve, consent or authorize any matter
whatsoever (including with respect to the merger, consolidation or conversion of
the LLC and any other matters that may otherwise require consent of members or
any class of members under the Act) except as set forth in the next sentence. 
Notwithstanding the forgoing, the affirmative consent of (i) the Class B Members
shall be required to the extent specifically set forth in Sections 3.11, 5.4,
14.1 and 15.1, (ii) the Class C Members shall be required to the extent
specifically set forth in Sections 3.11, 14.1 and 15.1(d) and (iii) the
Non-Contributing Member shall be required to the extent required pursuant to
Section 4.2.  A Member who has assigned some, but not all, of its Units shall be
treated as a Member and entitled to a vote on all matters such Member would
otherwise be entitled to vote on pursuant to the terms of this Agreement to the
extent of its retained Units.  For the avoidance of doubt, the assignee of Units
shall not be entitled to vote on any matters with respect to the assigned Units
unless and until admitted as a substitute Member pursuant to Section 12.9.

 

3.8                               Fiduciary Duties of Theravance Biopharma.  To
the fullest extent permitted by law (including Section 18-1101 of the Act) and
notwithstanding any duty otherwise existing at law or in equity, none of
Theravance Biopharma, its Affiliates or any of its or their respective
directors, officers, employees or shareholders shall have any fiduciary or
similar duty, at law or in equity, or any liability relating thereto, to the
LLC, or any other Member or Affiliate of a Member bound by this Agreement, with
respect to or in connection with the LLC or its business or affairs; and,
without limitation, Theravance Biopharma, its Affiliates and its or their
respective directors, officers, employees or shareholders, when approving or
disapproving any action, shall be entitled to consider only such interests and
factors as such Person desires and may consider its own interests and shall have
no other duty or obligation, fiduciary or otherwise, to give any consideration
to any interest of or factors affecting the LLC, or any other Member or
Affiliate of any other Member.  For the avoidance of doubt, Theravance
Biopharma, its Affiliates and its and their respective directors, officers,
employees and shareholders may engage in or possess an interest in other
profit-seeking or business ventures of any kind, nature or description,
independently or with others, whether or not such ventures are competitive or in
conflict with the LLC, any other Member, any Affiliate of any other Member or
any other Person bound by this Agreement, and notwithstanding any duty otherwise
existing at law or in equity, the doctrine of corporate opportunity, or any
analogous doctrine, shall not apply to Theravance Biopharma, its Affiliates or
their respective directors, officers, employees or shareholders.

 

To the extent that Theravance Biopharma, its Affiliates or its or their
respective directors, officers, employees or shareholders acquires knowledge of
a potential transaction, agreement, arrangement or other matter that may be an
opportunity for the LLC, Theravance Biopharma, its Affiliates and its or their
respective directors, officers, employees and shareholders shall have no duty to
communicate or offer such opportunity to any such Person.

 

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Theravance Biopharma, its Affiliates and its or their respective directors,
officers, employees and shareholders shall not be liable to the LLC, any Member,
any Affiliate of any other Member or any other Person bound by this Agreement
for breach of any fiduciary or other duty by reason of the fact that Theravance
Biopharma, its Affiliates or their respective directors, officers, employees or
shareholders pursues or acquires for, or directs such opportunity to, another
Person or does not communicate such opportunity or information to the LLC, any
Member, any Affiliate of any other Member or any other person bound by this
Agreement.  Neither the LLC, any Member, any Affiliate of any other Member nor
any other Person bound by this Agreement shall have any rights or obligations by
virtue of this Agreement or the relationship created hereby in or to such
independent ventures of Theravance Biopharma, its Affiliates, or their
respective directors, officers, employees or shareholders or the income or
profits or losses derived therefrom, and the pursuit of such ventures, even if
competitive or in conflict with the activities of the LLC, shall not be deemed
wrongful or improper.  Notwithstanding the foregoing, this paragraph shall not
apply to any such opportunity that Theravance Biopharma, its Affiliates or its
or their respective directors, officers, employees or shareholders acquires
knowledge of solely by virtue of Theravance Biopharma being a member of the LLC,
provided that any Person asserting that Theravance Biopharma, its Affiliates or
its or their respective directors, officers, employees or shareholders acquired
knowledge of such an opportunity solely by virtue of Theravance Biopharma being
a member of the LLC shall bear the burden of proving such assertion.

 

Nothing in this Section 3.8 shall modify, restrict or eliminate (i) any duty or
obligation of the Manager or Theravance expressly provided in Section 5.2 or in
any other section of this Agreement, (ii) any express obligation or restriction
contained in any other written contract or (iii) the implied contractual
covenant of good faith and fair dealing.

 

3.9                               Related Party Transactions.  Except as
specifically provided in this Agreement (but without limiting the application of
Section 5.2), the LLC may not enter into any transaction or contract with
Theravance, the Manager or any of their respective Affiliates, and the LLC may
not pay Theravance, the Manager or any of their Affiliates fees, compensation or
remuneration in connection with such transactions and contracts, unless the
terms, conditions, fees, compensation and other remuneration shall be no less
favorable to the LLC than those generally being provided to or available from
unaffiliated third parties.  Theravance, the Manager or any of their Affiliates
entering into any such transaction or contract or receiving such fees,
compensation or remuneration shall bear the burden of proving compliance with
this Section 3.9, but shall not be required to prove that any transaction or
contract is “entirely fair” or that the transaction or contract was the result
of a “fair process,” as such terms are interpreted and defined by decisions of
Delaware state and federal courts.

 

3.10                        Relationship of Members.  The Members and the
Manager intend and agree that the LLC is and shall be an “Affiliate” of
Theravance within the meaning of the GSK Agreements, and this Agreement shall be
interpreted accordingly.

 

3.11                        Cancellation of Units.  The Class A Units may not be
cancelled without the consent of a Majority in Interest of the Class A Members. 
The Class B Units may not be cancelled without the affirmative vote of a
Majority in Interest of the Class B Members.  The Class C Units may not be
cancelled without the affirmative vote of a Majority in Interest of the Class C
Members.

 

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3.12                        Compliance with GSK Agreements by Theravance and the
LLC.  Notwithstanding any other provision contained herein, Theravance, with
respect to the rights and obligations under the GSK Agreements not assigned to
the LLC pursuant to this Agreement, shall not, and, with respect to the rights
and obligations assigned to the LLC pursuant to this Agreement, shall cause the
Manager not to, and the Manager shall not, take (or omit to take) any action
(including, without limitation, the disclosure of any information to any
Member), that is or would be reasonably expected to result in a breach or
violation of, or be in conflict with, any term or condition of the GSK
Agreements or otherwise is or would be reasonably expected to give GSK the right
to terminate or invalidate any GSK Agreement or any term and condition thereof. 
Theravance agrees and understands that monetary damages would not adequately
compensate the holders of Class B Units and Class C Units for the breach of this
Section 3.12 by Theravance, that this Section 3.12 shall, to the fullest extent
permitted by law, be specifically enforceable, and that any breach or threatened
breach of this Section 3.12 shall be the proper subject of a temporary or
permanent injunction or restraining order.  Further, Theravance waives, to the
fullest extent permitted by law, any claim or defense that there is an adequate
remedy at law for such breach or threatened breach.  Notwithstanding anything
else to the contrary, in the event of any conflict between Section 3.12, or any
covenant, agreement, obligation or duty of Theravance or its Affiliates under
this Section 3.12, on the one hand, and any other provision of this Agreement or
any Exhibit or Attachment hereto, or any covenant, agreement, obligation or duty
of Theravance or its Affiliates thereunder, on the other hand, Section 3.12
shall govern and supersede such other provision, Exhibit, Attachment, covenant,
agreement, obligation or duty.

 

3.13                        Performance of Obligations by Manager.  Theravance
(i) shall cause the Manager to at all times and in good faith perform fully it
duties and obligations set forth in this Agreement and (ii) shall be liable to
the Members to the extent the Manager fails to do so.

 

3.14                        Theravance Triggering Event.  Without limiting the
rights, including, without limitation, rights to pursue remedies for breaches,
of any Member under this Agreement, including, without limitation,
Section 5.4(c) hereof, upon the occurrence of a Theravance Triggering Event,
Theravance shall pay or cause to be paid to the LLC when due all payments that
Theravance would otherwise be entitled to receive from GSK pursuant to Sections
6.1, 6.2 and 6.3 of the Collaboration Agreement and of the Strategic Alliance
Agreement relating directly or indirectly to the Assigned Products, as such
agreements are in effect as of immediately prior to the Theravance Trigger Event
(the “Theravance Triggering Event Date GSK Agreements”), had such Theravance
Triggering Event not occurred and regardless of whether Theravance actually
receives any such payments from GSK.  For the avoidance of doubt, the obligation
of Theravance to pay or cause to be paid payments under the Theravance
Triggering Event Date GSK Agreements pursuant to the immediately preceding
sentence shall not accelerate or change if or when such payments would otherwise
be due under such agreements.

 

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ARTICLE IV

 

CONTRIBUTIONS TO CAPITAL; WITHDRAWALS; ADVANCES

 

4.1                               Initial Capital Contribution by Theravance.

 

(a)                                 At the Contribution Time, Theravance shall
(and, effective automatically upon the Contribution Time, hereby does) transfer,
contribute, assign, distribute and convey, or cause to be transferred,
contributed, assigned, distributed and conveyed, to the LLC all of Theravance’s
right, title and interest in and to (i) all of the rights and benefits of
Theravance under the Strategic Alliance Agreement, (ii) all of the rights and
benefits of Theravance under the Collaboration Agreement relating to the
Assigned Collaboration Products, including the rights and benefits specified on
Exhibit C, and (iii) the Assigned Assets (collectively, the “Assignment”).

 

(b)                                 At the Contribution Time, the LLC shall,
and, effective automatically upon the Contribution Time, hereby does, accept the
Assignment from Theravance.

 

(c)                                  Except as otherwise specifically set forth
in this Agreement, (i) at the Contribution Time, Theravance shall (and,
effective automatically upon the Contribution Time, hereby does) assign and
delegate to the LLC, and the LLC shall (and, effective automatically upon the
Contribution Time, hereby does) accept, assume or, as applicable, retain (A) all
Liabilities under the Strategic Alliance Agreement, (B) all of the Liabilities
under the Collaboration Agreement relating to the Assigned Collaboration
Products, including the Liabilities specified on Exhibit C attached hereto, and
(C) the Assumed Liabilities and (ii) after the Contribution Time, the LLC shall
perform, discharge and fulfill, in accordance with their respective terms, all
such Liabilities, in each case, unless specified otherwise in the definition of
the Assumed Liabilities, regardless of (A) when or where such Liabilities arose
or arise, (B) where or against whom such Liabilities are asserted or determined,
(C) which entity is named in any action associated with any Liability, and
(D) whether the facts on which they are based occurred prior to, on or after the
Contribution Time (the “Assumption”).  Notwithstanding the foregoing, the LLC
shall not assume any Liability attributable to (i) the failure of Theravance
and/or the Manager or their respective officers, directors, employees, agents or
Affiliates to perform Theravance’s obligations to the LLC pursuant to this
Agreement or the Ancillary Agreements or (ii) any breach of this Agreement, the
Ancillary Agreements or any other agreement with any Person, including the GSK
Agreements, occurring on or after the Contribution Time, nor any matter to the
extent that Theravance and/or the Manager or their respective officers,
directors, employees, agents or Affiliates has engaged in any violation of Law,
any gross negligence, willful misconduct or fraud.

 

(d)                                 If at any time after the Contribution Time,
the parties hereto agree that Theravance possesses any assets and/or liabilities
related to the LLC Business (and not to the Theravance Business) that constitute
Assigned Assets, Theravance shall as promptly as practicable transfer or cause
to be transferred to the LLC, at the expense of the LLC, and the LLC shall
accept such transfer and/or assume, for no consideration, such asset and/or
liability, including any and all economic benefits generated from such asset
and/or liability after the Contribution Time, to the LLC.  Each such transferred
asset and/or liability shall be deemed a

 

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LLC Asset or a LLC Liability, respectively, and shall be subject to the terms
and conditions of this Agreement applicable thereto.

 

(e)                                  If at any time, after the Contribution
Time, the parties hereto agree that the LLC possesses any assets or liabilities
solely related to the Theravance Business (and not to the LLC Business) the
rights to which were obtained from Theravance in connection with this Agreement,
the LLC shall as promptly as practicable transfer or cause to be transferred, at
Theravance’s expense, and Theravance shall accept such transfer and/or assume,
for no consideration, such asset and/or liability, including any and all
economic benefits generated from such asset and/or liabilities after the
Contribution Time, to Theravance.

 

(f)                                   At the Contribution Time (or thereafter
upon reasonable request and at the requesting party’s expense), (i) Theravance
shall execute and deliver such bills of sale, stock powers, certificates of
title, assignments of contracts and other instruments of transfer, conveyance
and assignment as and to the extent necessary to evidence the Assignment, and
(ii) the LLC shall execute and deliver to Theravance such bills of sale, stock
powers, certificates of title, assumptions of contracts, indemnity agreements
and other instruments of assumption as and to the extent necessary to evidence
the valid and effective Assumption.

 

(g)                                  To the extent that any part of the
Assignment or Assumption requires any Governmental Approvals, the parties hereto
shall use commercially reasonable efforts to obtain any such Governmental
Approvals.  If and to the extent that such part of the Assignment or Assumption
would be a violation of applicable laws or require any Governmental Approval,
then, unless Theravance shall otherwise determine, such part of the Assignment
to or Assumption by the LLC, shall be automatically deemed deferred and any such
purported Assignment or Assumption shall be null and void until such time as all
legal impediments are removed and/or each of such Governmental Approval has been
obtained.

 

(h)                                 The Members shall use commercially
reasonable efforts to obtain any Consents required in connection with the
transactions contemplated by this Agreement.  Notwithstanding the foregoing, no
Member shall be obligated to pay any consideration therefor to any Third Party
from whom any such Consent, substitution or amendment is requested.

 

(i)                                     If any Assignment or Assumption intended
to be Transferred and assumed hereunder is not consummated as of the
Contribution Time, whether as a result of the provisions of Section 4.1(g) or
otherwise, then Theravance shall thereafter hold such LLC Asset for the use and
benefit of the LLC if permitted by Law.  If and when the Consents and/or
Governmental Approvals, or any other impediments to Assignment or Assumption,
the absence of which caused the deferral of Assignment of any LLC Asset or
Assumption pursuant to Section 4.1(g) or otherwise, are obtained or removed (as
appropriate), the Assignment of the applicable LLC Asset or Assumption of the
applicable LLC Liability shall be effected in accordance with the terms of this
Agreement.  With respect to any LLC Asset retained by Theravance due to the
deferral of the Assignment of such LLC Asset, Theravance shall take such actions
with respect to such LLC Asset as may be reasonably requested by the LLC.

 

(j)                                    If the Members are unable to obtain, or
to cause to be obtained, any such required Governmental Approvals, Consents,
release, substitution or amendment pursuant to

 

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Section 4.1(h) or otherwise, Theravance shall (i) continue to be bound by such
Contract, license or other obligation, which shall not constitute a Liability of
Theravance (unless not permitted by Law or the terms thereof), (ii) as agent or
subcontractor for the LLC, pay, perform and discharge fully all the obligations
or other Assumed Liabilities thereunder after the Contribution Time, and
(iii) deliver to the LLC any payments, benefits or other consideration received
by Theravance under such Contract, license or other obligation; provided,
however, that Theravance shall not be obligated to extend, renew or otherwise
cause such Contract, license or other obligation to remain in effect beyond the
term in effect as of the Contribution Time.  At the request of the Manager,
Theravance shall exercise its rights under such Contract, license or other
obligation for the benefit of the LLC.  The LLC shall fully indemnify Theravance
and its Affiliates, officers, directors, employees and agents for, and hold each
of them harmless against, any and all obligations or Assumed Liabilities arising
in connection therewith and also for any actions requested by the Manager
pursuant to this Section 4.1(j), provided, however, that the LLC shall have no
obligation to indemnify Theravance or its Affiliates, officers, directors,
employees or agents with respect to any matter to the extent that Theravance,
the Manager or their respective Affiliates, officers, directors, employees or
agents has (i) engaged in any violation of Law, (ii) committed gross negligence
or fraud or (iii) breached this Agreement, the Ancillary Agreements or any other
agreement with any Person, including the GSK Agreements.  Theravance shall,
without further consideration, promptly pay and remit, or cause to be promptly
paid or remitted, to the LLC, all money, rights and other consideration received
by it or any of its Affiliates in respect of such performance on behalf of the
LLC.  If and when any such Governmental Approval, Consent, release, substitution
or amendment shall be obtained or such agreement, lease, license or other rights
or obligations shall otherwise become assignable or capable of novation,
Theravance shall promptly assign, or cause to be assigned, all rights,
obligations and other Assumed Liabilities thereunder of Theravance’s to the LLC
without payment of any further consideration and the LLC, without the payment of
any further consideration, shall assume such rights and obligations and other
Assumed Liabilities.

 

(k)                                 If any Intellectual Property owned by
Theravance (or Theravance Biopharma) as of the Contribution Time that is
relevant to the LLC Business, Assigned Assets, or Assigned Products is not
assigned to the LLC hereunder (or if it is assigned back to Theravance under
Section 3.1(e)), the LLC will have and is hereby granted a nonexclusive,
worldwide, perpetual, irrevocable, sublicensable, transferable license to
exercise such Intellectual Property only with respect to the LLC Business,
Assigned Assets and/or Assigned Products.

 

(l)                                     If any Intellectual Property assigned to
the LLC hereunder (other than Intellectual Property referred to in clause (a),
(b) or (c) of the definition of “Assigned Assets”) is relevant to the Theravance
Business or Retained Products, Theravance will have and is hereby granted a
nonexclusive, worldwide, perpetual, irrevocable, sublicensable, transferable
license to exercise such Intellectual Property only with respect to the
Theravance Business and/or Retained Products.

 

4.2                               Additional Capital Contributions.  Except as
otherwise provided pursuant to this Section 4.2, no Member shall be permitted or
required to make any additional Capital Contribution without the consent of the
Manager and such Member.  Notwithstanding the foregoing, the Manager shall
request each Member to make a Capital Contribution on the first

 

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Business Day of each Fiscal Quarter equal to its LLC Percentage of the Projected
Capital Contribution for that Fiscal Quarter.  If a Member fails to make a
requested Capital Contribution pursuant to this Section 4.2 (a “Non-Contributing
Member”) within ten (10) Business Days after receiving such request, any other
Member shall be permitted, but not required, to advance any shortfall in the
Capital Contribution of such Non-Contributing Member in accordance with
Section 4.5 below but only with the prior written consent of the
Non-Contributing Member if, and only if, such Non-Contributing Member holds at
least a majority of the then outstanding Units.

 

4.3                               Interest.  No Member shall be entitled to any
interest or compensation with respect to such Member’s Capital Contribution or
share of the capital of the LLC, except as expressly provided herein.  No Member
shall have any liability for the repayment of the Capital Contribution of any
other Member and each Member shall look only to the assets of the LLC for return
of such Member’s Capital Contributions to the extent permitted herein.

 

4.4                               No Right of Withdrawal.  No Member shall have
the right to withdraw or receive any return of, or interest on, any portion of
such Member’s contributions to the capital of, or to receive any distributions
from, the LLC, except as provided in Articles XI and XIV.

 

4.5                               Advances.  If any Member shall advance any
funds to the LLC in excess of its Capital Contributions pursuant to Sections 4.1
and 4.2, the amount of such advance shall neither increase its Capital Account
nor entitle that Member to any increase in its share of the distributions of the
LLC.  The amount of any such advance shall be a debt obligation of the LLC to
such Member and shall be repaid to it by the LLC with interest at a rate and
upon such other terms and conditions which the Manager reasonably determines in
good faith are, taken as a whole, generally consistent with the interest rate
and other terms and conditions that would be available to the LLC from an
unrelated commercial lender, as shall be agreed by the Manager and such Member. 
Any such advance shall be payable and collectible only out of the assets of the
LLC and the other Members shall not be personally obligated to repay any part
thereof.  No Person that makes any advance to the LLC pursuant to this
Section 4.5 shall have or acquire, as a result of making such loan, any direct
or indirect interest in the profits, capital or property of the LLC, other than
as a creditor.

 

ARTICLE V

 

MANAGEMENT, EXPENSES AND RESTRICTIONS

 

5.1                               Management by Manager; Manager.

 

(a)                                 Management by Manager.  Subject to and in
accordance with this Agreement, the Manager shall have decision-making authority
as to the LLC, including the authority to (i) manage the business and affairs of
the LLC, (ii) exercise all powers of the LLC, and (iii) do all lawful acts on
behalf of the LLC.  The Manager may act by one or more committees designated by
the Manager in accordance with Section 5.1(c).  The Manager shall be a “manager”
within the meaning of Section 18-101(10) and Section 18-402 of the Act.  No
Member shall have the right, power or authority to act on behalf of or bind the
LLC, except that a Member who is also a Manager or an Officer of the LLC may act
on behalf of or bind the LLC

 

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in its capacity as a Manager or an Officer of the LLC to the extent that he or
she is authorized to do so.

 

(b)                                 Appointment of the Manager.  The Manager
shall be appointed by a Majority in Interest of the Class A Members and must be
Theravance or a Theravance Affiliate.  The initial Manager shall be as set forth
on Exhibit B.  Any Manager may be removed at any time by a Majority in Interest
of the Class A Members, provided that they simultaneously appoint a successor
Manager that must be Theravance or a Theravance Affiliate.  Upon appointment of
any Manager, the Manager shall, and Theravance shall cause such Manager to,
execute and deliver to the LLC a counterpart of this Agreement, which execution
and delivery shall evidence such Manager’s express agreement to be a party to,
and be bound by, this Agreement.  When the Majority in Interest of the Class A
Members act as Manager since no Person is then appointed as Manager pursuant to
this Section 5.1, the other holders of Class A Units agree to be bound by the
actions of the Majority in Interest of the Class A Members.

 

(c)                                  Committees, General.  The Manager may, by
resolution passed by the Manager, designate one or more committees of the LLC. 
Any such committee, to the extent provided in the resolution of the Manager,
shall have and may exercise all the powers and authority of the Manager.  Such
committee or committees shall have such name or names as may be determined from
time to time by resolution adopted by the Manager.  Each committee shall keep
regular minutes of its meetings and report the same to the Manager when
required.  No employees, consultants or representatives of Theravance Biopharma
shall be members of any such committee, except for Permitted Consultants.

 

5.2                               Fiduciary Duties of Theravance and the
Manager.  Notwithstanding any duty otherwise existing at law or in equity, to
the fullest extent permitted by law (including Section 18-1101 of the Act), the
Manager shall have the fiduciary duties of directors of a board of directors,
provided that following a Theravance Biopharma Triggering Event, the Manager
shall be entitled to the benefit of the business judgment rule in all
circumstances other than those in which the Manager has acted in bad faith, and,
prior to a Theravance Biopharma Triggering Event, Theravance (for so long as it
is the direct or indirect holder of a Majority in Interest of the Class A Units)
and any other holder of Class A Units (for so long as such holder, together with
its Affiliates, is the direct or indirect holder of a Majority in Interest of
the Class A Units) shall have the fiduciary duties of a controlling stockholder,
in each case of a for-profit stock corporation organized and existing under the
DGCL to which provisions of Subchapter XIV of the DGCL, 8 Del. Ch. §§ 341 ff.,
are not applicable, as such duties and responsibilities are interpreted and
defined by decisions of state and federal courts having jurisdiction to
interpret and define the same.  The provisions of this Agreement (including,
without limitation, Section 3.8 and this Section 5.2), to the extent that they
expand, restrict or eliminate the duties and liabilities of a Member, the
Manager or an Affiliate of a Member or the Manager otherwise existing at law or
in equity, are agreed by the parties hereto to replace such other duties and
liabilities of such Person.

 

5.3                               Duties of the Manager.  Without limiting the
generality of Section 5.1 but subject to Section 10.1, at the expense of the
Manager, the responsibilities of the Manager shall include the following:

 

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(a)                                 Subject to Section 3.12, prepare, and
maintain at the principal place of business of the LLC the Books and Records of
the LLC, including, without limitation, the following:

 

(i)                                     Proper and complete records and books of
account, including without limitation Capital Accounts in which shall be entered
fully and accurately all transactions relating to the LLC Business in such
detail and completeness as is customary and usual for businesses of the type
engaged in by the LLC.

 

(ii)                                  A copy of the Certificate of Formation of
the LLC and all amendments thereto, together with executed copies of any powers
of attorney pursuant to which any amendment has been executed.

 

(iii)                               Copies of the federal, state, and local
income tax returns and reports of the LLC for the seven (7) most recent years.

 

(iv)                              Copies of the LLC’s currently effective
written operating agreement.

 

(v)                                 Copies of financial statements of the LLC
for the seven (7) most recent years.  For the avoidance of doubt, the financial
statements of the LLC shall at a minimum include a balance sheet, statement of
operations (including, without limitation, the Net Income, Net Loss and items
thereof of the LLC for the applicable accounting period) and cash flow
statement.

 

(vi)                              Minutes of every annual, special meeting and
court-ordered meeting.

 

(vii)                           Any written consents obtained from Members for
actions taken by Members without a meeting.

 

(b)                                 Prior to a Theravance Biopharma Triggering
Event, be responsible for the day-to-day management of the Assigned Products in
accordance with the terms and conditions of the GSK Agreements;

 

(c)                                  Prior to a Theravance Biopharma Triggering
Event, use all commercially reasonable efforts to maximize the commercial value
of the Assigned Products in accordance with and subject to the terms of the GSK
Agreements; provided, however, that, for the avoidance of doubt, the Manager
shall not be required to cause GSK to take any actions or inactions except to
the extent such actions or inactions are required to be performed by GSK
pursuant to the GSK Agreements;

 

(d)                                 Prior to a Theravance Biopharma Triggering
Event, exercise the rights and perform the obligations of the LLC as assignee
under the GSK Agreements, including the appointment of representatives to any
Joint Steering Committee or Joint Product Committee to the extent permitted
under any GSK Agreement;

 

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(e)                                  Subject to Section 3.12, prepare a
quarterly financial plan for the LLC (a “Financial Plan”), consisting of (i) a
balance sheet, (ii) capital expenditures (if any), (iii) Management Costs,
(iv) LLC Costs and (v) Projected Capital Contributions.  Subject to
Section 3.12, the Manager shall (A) distribute to each Member a draft of each
Financial Plan and any amendment or modification thereto at least thirty (30)
days prior to the first day of the Fiscal Quarter and a draft of each amendment
or other modification to a Financial Plan at least fifteen (15) days before it
is effective, (B) provide each Member with a reasonable opportunity to comment
on such Financial Plan or amendment or other modification thereto within such
timeframe and (C) consider in good faith any and all comments received from the
Members.  Notwithstanding anything else in this clause (e) to the contrary, in
no event will the Financial Plan or any amendment or other modification thereto
include or be based on any sales forecast provided or delivered by GSK under the
GSK Agreements (or other Confidential Information (as defined in the GSK
Agreements)) but shall only be based on publicly available information,
including analysts’ consensus estimates.

 

(f)                                   Notify each Member at least thirty (30)
days before the start of each Fiscal Quarter of such Member’s requested Capital
Contribution to the LLC for that Fiscal Quarter pursuant to Section 4.2; and

 

(g)                                  Take all actions necessary to ensure that
the formation, structure and operation of the LLC comply with this Agreement,
applicable law and the GSK Agreements.

 

5.4                               Limitation of Authority of Manager.  The
Manager shall obtain the approval of a Majority in Interest of the Class A
Members and a Majority in Interest of the Class B Members before the Manager
shall take any of the following actions:

 

(a)                                 Except for advances pursuant to Section 4.6,
borrow on behalf of the LLC;

 

(b)                                 Issue an Interest, or the right to acquire
an Interest, in the LLC or any other debt or equity security therein;

 

(c)                                  Take any action or omit to take any action
that would be reasonably expected to have a direct or indirect material and
adverse effect on (i) the rights, preferences, privileges of or obligations
relating to the Class B Units or Class C Units or (ii) the economic interest
represented by the Class B Units or Class C Units, in each case, whether by
merger, reorganization, transfer of assets, consolidation, dissolution, issuance
or sale of securities, amendment, failure to perform or waiver of rights or
obligations under this Agreement or the GSK Agreements or otherwise; provided,
however, that the Manager’s actions or failure to act with regard to Development
and Commercialization (as each such term is defined in the applicable GSK
Agreement) matters under the GSK Agreements that are based on the Manager’s good
faith determination that GSK is complying with its respective diligent efforts
obligations under the GSK Agreements shall not require approval under clause
(ii) of this Section 5.4(c); and provided, further however, that (x) following
the Transfer of all or any portion of the Interests with respect to any Class B
Units to any Person other than Theravance Biopharma, its direct or indirect
wholly-owned subsidiaries, or the successors to all or substantially all of the
assets of Theravance Biopharma, whether by merger, sale of stock, sale of assets
or other similar transaction, or its or their successors or direct or indirect
wholly-owned subsidiaries, and

 

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(y) pursuant to the dissolution and winding up of the affairs of the LLC in
accordance with Article XIV, to the extent the Manager’s actions are consistent
with a plan of dissolution and winding up of the affairs of the LLC approved
pursuant to Section 14.1(a), the approval by the Class B Members of the actions
described in this clause (c) shall not be required (and for the avoidance of
doubt shall not be required regardless of whether such other Person continues to
hold Class B Units);

 

(d)                                 Take any action or omit to take any action
that would cause the LLC to be treated as engaged in a trade or business (either
directly or through an investment in another partnership or limited liability
company) within the United States for purposes of Sections 875, 882, 884 and
1446 of the Code; and

 

(e)                                  Invest in United States real property
interests as that term is defined in Section 897 of the Code.

 

ARTICLE VI

 

NOTICES

 

6.1                               Notices.  Any notice, payment, demand or other
communication required or permitted to be given by any provision of this
Agreement shall be deemed to have been delivered and given for all purposes
(i) if delivered personally to the party or to an officer of the party to whom
the same is directed, when received by such party, (ii) if delivered by
confirmed telecopy transmission, when received if received on a Business Day
during normal business hours of the recipient, and if not, on the next Business
Day, (iii) by a nationally recognized overnight courier service or (iv) whether
or not the same is actually received, if sent by registered or certified mail,
return receipt requested, postage and charges prepaid, addressed as follows:  If
to the LLC, at its principal place of business the address of which is set forth
in Section 2.2; if to a Member, at such Member’s address set forth on Exhibit A
hereto, or to such other address as such Member may from time to time specify by
written notice to the Members and the LLC; such notice shall be deemed to be
given five (5) days after the date on which the same was deposited in a
regularly maintained receptacle for the deposit of United States mail, addressed
and sent as aforesaid.  Any party may by written notice to the other parties
specify a different address or facsimile number for notice purposes by sending
notice thereof in the foregoing manner.

 

6.2                               Waiver of Notice.  Whenever any notice is
required to be given under the provisions of the Act, the Certificate or this
Agreement, a waiver thereof in writing, signed by the Person or Persons entitled
to said notice, whether before or after the time stated therein, shall be deemed
equivalent thereto.

 

ARTICLE VII

 

OFFICERS

 

7.1                               Officers.

 

(a)                                 The Manager may, from time to time,
designate one or more Persons to be officers of the LLC (each such person an
“Officer”).  Any Officers designated by the Manager

 

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shall have such authority and perform such duties as the Manager may, from time
to time, delegate to them.  The Manager may assign titles to particular
Officers.  Any number of offices may be held by the same person.  No Officer
need be a resident of the State of Delaware or of the United States of America. 
No Officer shall be an employee, consultant or representative of Theravance
Biopharma, except for Permitted Consultants.

 

(b)                                 Each Officer shall hold office until his or
her successor shall be duly designated and qualified or until his or her death
or until he or she shall resign or shall have been removed in the manner
hereinafter provided.

 

(c)                                  Any Officer may resign as such at any
time.  Such resignation shall be made in writing and shall take effect at the
time specified therein, or if no time be specified, at the time of its receipt
by the Manager.  The acceptance of a resignation shall not be necessary to make
it effective, unless expressly so provided in the resignation.

 

(d)                                 Any Officer may be removed as such, either
with or without cause, by the Manager whenever in its judgment the best
interests of the LLC will be served thereby.  Any vacancy occurring in any
office of the LLC may be filled by the Manager.

 

(e)                                  To the fullest extent permitted by law, and
in all instances solely to the extent not inconsistent with the specific
provisions of this Agreement, it is the intention of the parties that those
Officers with titles expressly referenced in the DGCL or customarily used in
corporations organized under the DGCL, in their respective capacities as such,
shall, unless otherwise provided herein or determined by the Manager, have the
statutory and customary rights, powers, authority, duties and responsibilities
of officers with similar titles of a for-profit stock corporation organized and
existing under the DGCL.  Notwithstanding the foregoing, no Officer shall have
any right, power or authority to cause the LLC to enter into any transaction or
to take or fail to take any other action that requires any consent, approval or
waiver (i) of the Managers or any Members (including a Majority in Interest of
the Class A Members or a Majority in Interest of the Class B Members),
(ii) pursuant to the terms of this Agreement or (iii) under applicable law, in
each case without obtaining in advance such consent, approval or waiver.  Each
Officer is hereby delegated such rights, powers and authority with respect to
the management of the business and affairs of the LLC as may be necessary or
advisable to effect the provisions of this Section 7.1(e).

 

(f)                                   The initial Officers of the LLC shall be
those individuals designated as the Officers on Exhibit B.

 

7.2                               Reliance by Third Parties.  In dealing with
the LLC and its duly appointed agents, no Person shall be required to inquire as
to the LLC’s or such agents’ authority to bind the LLC.

 

7.3                               Actions and Determinations of the LLC.  Except
as otherwise expressly provided herein, whenever this Agreement provides that a
determination shall be made or an action shall be taken by the LLC, such
determination or act shall be made or taken by the Manager or, pursuant to this
Agreement or with the authorization of the Manager (which may be

 

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a general authorization and need not be specific as to any named person, Officer
or particular transaction), by any Officer.

 

ARTICLE VIII

 

ACCOUNTING AND RECORDS

 

8.1                               Financial and Tax Reporting.  The Manager
shall prepare financial statements for the LLC and the income tax information
returns for the LLC using such methods of accounting and tax year as the Manager
deems necessary or appropriate as permitted by the Code and Treasury
Regulations.

 

8.2                               Members Access to Certain Information. 
Subject to Section 8.6 and the obligation of Theravance and the Manager to
withhold information pursuant to Section 3.12, the Manager shall make available,
upon at least three (3) Business Days’ prior written notice to the Manager, for
inspection at reasonable times during business hours by a Member, for any reason
or no reason, the Books and Records of the LLC, in each case including, without
limitation, the information, documents and other materials identified in
Sections 18-305(a)(1)-(6) of the Act).

 

8.3                               Books and Records.  Proper and complete books
and records of the LLC (including those books and records identified in the Act)
shall be kept at the LLC’s principal office and at any other place as designated
by the Manager.

 

8.4                               Tax Returns.  The LLC shall cause appropriate
tax reports and returns (including an IRS Form 1065, Schedule K-1) to be
prepared and delivered in a timely manner to each of the Members and to any
relevant tax authority within ninety (90) days after the close of each Fiscal
Year (subject to reasonable delays in the event of the late receipt of any
necessary financial information necessary to prepare tax returns of the LLC, but
in no event later than one hundred twenty (120) days after the close of each
Fiscal Year).

 

8.5                               Tax Matters Partner.  The Member identified on
Exhibit B as the Tax Matters Member is hereby designated as the LLC’s “Tax
Matters Partner” for purposes of the Code.

 

8.6                               Confidentiality.

 

(a)                                 Each Member hereby acknowledges that by
virtue of such Member’s Interests, such Member, its Affiliates and its and their
respective officers, directors, employees, agents and representatives may have
access, or the LLC may allow such Member, its Affiliates and its and their
officers, directors, employees, agents and representatives access, to business,
technical, other information, materials and/or ideas or this Agreement
(“Proprietary Information,” which term shall include, without limitation,
anything such Member learns or discovers as a result of exposure to or analysis
of any Proprietary Information).  Therefore, each Member hereby agrees that such
Member will, and shall cause its Affiliates and its and their officers,
directors, employees, agents and representatives to hold in confidence and will
not, and will cause its officers, directors, employees, agents, representatives
and Affiliates not to, possess or use (except as required to exercise rights or
perform obligations under this Agreement or to enforce its obligations under
this Agreement) or disclose any Proprietary Information without the prior
written consent of the Manager, except such information that (i) was in the
public domain

 

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prior to the time it was furnished to such Member, (ii) is or becomes (through
no willful improper action or inaction by such Member) generally available to
the public, (iii) was in its possession or known by such Member, its Affiliates
or its and their respective officers, directors, employees, agents and
representatives without restriction prior to receipt from the LLC, (iv) was
rightfully disclosed to such Member, its Affiliates or its and their respective
officers, directors, employees, agents and representatives by a third party
without restriction, (v) was independently developed without any use of
Proprietary Information, (vi) legal counsel, accountants or representatives for
such Member, its Affiliates or its and their respective officers, directors,
employees, agents and representatives who are bound by a duty of confidentiality
request to see, or (vii) subject to the last sentence of clause (b)  below, is
required to be disclosed by law or the rules of any national securities
exchange, association or marketplace, provided that, the Member shall notify the
LLC of any such disclosure requirement as soon as practicable and reasonably
cooperate with the LLC (at the LLC’s cost) if the LLC seeks a protective order
or other remedy in respect of any such disclosure; and furnish only that portion
of the Proprietary Information which the Member is legally required to
disclose.  Each Member agrees that is will not reverse engineer or attempt to
derive the composition or underlying information, structure or ideas of any
Proprietary Information.  The foregoing does not grant any Member a license in
or to any of the Proprietary Information.  In accordance herewith, each Member
also acknowledges and agrees that due to the unique nature of the Proprietary
Information, any breach of this Section 8.6 would cause irreparable harm to the
LLC for which damages are not an adequate remedy, and that the LLC shall
therefore be entitled to seek equitable relief in addition to all other remedies
available at law.

 

(b)                                 To the maximum extent permitted by the Act,
subject to the provisions of this Agreement (including, without limitation, the
obligation of Theravance and the Manager to withhold information pursuant to
Section 3.12), the Manager shall have the right to keep confidential from the
Members or other Persons, for such period of time as the Manager deems
reasonable, any information (including, to the extent permitted by the Act, any
information for which a member or manager of a limited liability company may
otherwise be entitled to obtain or examine pursuant to Section 18-305 of the
Act) which the Manager reasonably in good faith believes to be in the nature of
trade secrets or other information the disclosure of which the Manager
reasonably in good faith believes is not in the best interest of the LLC or
could damage the LLC or its business or which the LLC is required by law or by
agreement with a third party (including the GSK Agreements) to keep
confidential.  Notwithstanding any other provision of this Agreement, but
without limiting any rights of Theravance to disclosure pursuant to Article 10
of the Collaboration Agreement and Strategic Alliance Agreement, no Member shall
disclose Confidential Information (as defined in the GSK Agreements) of GSK that
would otherwise be permitted to be disclosed solely pursuant to clause (vii) in
Section 8.6(a); provided that a Member may disclose such information to its
outside counsel and outside accountants on a need-to-know basis provided they
are subject to customary confidentiality obligations.

 

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ARTICLE IX

 

CAPITAL ACCOUNTS AND
ALLOCATIONS OF NET INCOME AND NET LOSS

 

9.1                               Capital Accounts.

 

(a)                                 A separate capital account (the “Capital
Account”) shall be established and maintained for each Member.  The Capital
Account of each Member shall be credited with such Member’s Capital
Contributions to the LLC (net of any liabilities secured by any contributed
property that the LLC is considered to assume or take subject to), all Net
Income allocated to such Member pursuant to Section 9.2 and any items of income
or gain which are specially allocated pursuant to Section 9.3; and shall be
debited with all Net Losses allocated to such Member pursuant to Section 9.2,
any items of loss or deduction specially allocated to such Member pursuant to
Section 9.3, and all cash and the Carrying Value of any property (net of
liabilities assumed by such Member and the liabilities to which such property is
subject) distributed to such Member.  To the extent not provided for in the
preceding sentence, the Capital Accounts of the Members shall be adjusted and
maintained in accordance with the rules of Treasury Regulations
Section 1.704-1(b)(2)(iv), as the same may be amended or revised.  Any
references in any section of this Agreement to the Capital Account of a Member
shall be deemed to refer to such Capital Account as the same may be credited or
debited from time to time as set forth above.  In the event of any Transfer of
any Interest in accordance with the terms of this Agreement, the transferee
shall succeed to the Capital Account of the transferor to the extent it relates
to the transferred Interest.  Whenever the LLC would be permitted to adjust the
Capital Accounts of the Members pursuant to Treasury Regulations
Section 1.704-1(b)(2)(iv)(f) to reflect revaluations of the property of the LLC,
the Manager may adjust the Capital Accounts of the Members if it determines that
doing so would be appropriate.  If Code Section 704(c) applies to LLC property,
the Capital Accounts of the Members shall be adjusted in accordance with
Treasury Regulations Section 1.704-1(b)(2)(iv)(g) for allocations of
depreciation, depletion, amortization and gain and loss, as computed for book
purposes, with respect to such property.  The Capital Accounts shall be
maintained for the sole purpose of determining the allocation of items of
income, gain, loss and deduction among the Members for tax purposes and shall
have no effect on the amount of any distributions to any Members in liquidation
or otherwise.

 

(b)                                 No Member shall be required to pay to the
LLC or to any other Member the amount of any negative balance which may exist
from time to time in such Member’s Capital Account.

 

9.2                               Allocations of Net Income and Net Loss.  Net
Income, Net Loss and items thereof of the LLC for each Fiscal Year (or other
Accounting Period) shall be allocated to the Members in such manner that:

 

(a)                                 Net Income for each Fiscal Quarter or
Interim Period shall be allocated to the Capital Accounts of the Members in
proportion to their respective LLC Percentages as of the end of such Fiscal
Quarter or Interim Period.

 

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(b)                                 Net Loss for each Fiscal Quarter or Interim
Period shall be allocated to the Capital Accounts of the Members in proportion
to their respective LLC Percentages as of the end of such Fiscal Quarter or
Interim Period.

 

9.3                               Special Allocation Provisions. 
Notwithstanding any other provision in this Agreement:

 

(a)                                 Minimum Gain Chargeback.  If there is a net
decrease in Partnership Minimum Gain or Partner Nonrecourse Debt Minimum Gain
(determined in accordance with the principles of Treasury Regulations Sections
1.704-2(d) and 1.704-2(i)) during any Fiscal Year or other Accounting Period
taxable year, the Members shall be specially allocated items of LLC income and
gain for such year (and, if necessary, subsequent years) in an amount equal to
their respective shares of such net decrease during such year, determined
pursuant to Treasury Regulations Sections 1.704-2(g) and 1.704-2(i)(5).  The
items to be so allocated shall be determined in accordance with Treasury
Regulations Section 1.704-2(f).  This Section 9.3(a) is intended to comply with
the minimum gain chargeback requirements in such Treasury Regulations Sections
and shall be interpreted consistently therewith; including that no chargeback
shall be required to the extent of the exceptions provided in Treasury
Regulations Sections 1.704-2(f) and 1.704-2(i)(4).

 

(b)                                 Qualified Income Offset.  In the event any
Member unexpectedly receives any adjustments, allocations, or distributions
described in Treasury Regulation Section 1.704-1(b)(2)(ii)(d)(4), (5) or (6),
items of LLC income and gain shall be specially allocated to such Member in an
amount and manner sufficient to eliminate the deficit balance in its Capital
Account (in excess of the amounts described in clauses (i) and (ii) of
Section 9.3(c) below) created by such adjustments, allocations or distributions
as promptly as possible.  This Section 9.3(b) is intended to constitute a
“qualified income offset” within the meaning of Treasury Regulation
Section 1.704-1(b)(ii)(d).

 

(c)                                  Limitation on Net Losses.  If any
allocation of Net Loss or an item of deduction, expenditure or loss to be made
pursuant to Section 9.2 or this Section 9.3 for any Fiscal Year or other
Accounting Period would cause a deficit in any Member’s Capital Account (or
would increase the amount of any such deficit) after (i) crediting to that
Capital Account the amount that such Member is deemed to be obligated to restore
pursuant to the penultimate sentences of Treasury Regulations
Section 1.704-2(g)(1) and 1.704-2(i)(5), and (ii) debiting to such Capital
Account the items described in Treasury Regulations 1.704-1(b)(2)(ii)(d)(4),
1.704-1(b)(2)(ii)(d)(5) and 1.704-1(b)(2)(ii)(d)(6), then such Net Loss or item
of deduction, expenditure or loss shall be allocated to the Members that have
positive Capital Account balances (in excess of the amounts described in clauses
(i) and (ii) of this section for such Member) in proportion to the respective
amounts of such positive balances until all such positive balances have been
reduced to zero.

 

(d)                                 Gross Income Allocation.  In the event any
Member has a deficit Capital Account at the end of any Fiscal Year which is in
excess of the sum of (i) the amount such Member is obligated to restore, if any,
pursuant to any provision of this Agreement, and (ii) the amount such Member is
deemed to be obligated to restore pursuant to the penultimate sentences of
Treasury Regulations Section 1.704-2(g)(1) and 1.704-2(i)(5), each such Member
shall be

 

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specially allocated items of LLC income and gain in the amount of such excess as
quickly as possible; provided that an allocation pursuant to this
Section 9.3(d) shall be made only if and to the extent that a Member would have
a deficit Capital Account in excess of such sum after all other allocations
provided for in this Article IX have been tentatively made as if
Section 9.3(c) and this Section 9.3(d) were not in this Agreement.

 

(e)                                  Nonrecourse Deductions.  Nonrecourse
Deductions shall be allocated in accordance with the number of Units held by
each Member and in the same manner as if such Nonrecourse Deductions were taken
into account in determining Net Income and Net Loss for such Accounting Period
or fiscal year.

 

(f)                                   Partner Nonrecourse Deductions.  Partner
Nonrecourse Deductions for any taxable period shall be allocated to the Member
who bears the economic risk of loss with respect to the liability to which such
Partner Nonrecourse Deductions are attributable in accordance with Treasury
Regulations Section 1.704-2(j).

 

(g)                                  Change in Interests.  If there is a change
in any Member’s Interest during any Fiscal Year, the principles of
Section 706(d) of the Code shall apply in allocating Net Income and Net Loss and
items thereof for such Fiscal Year to account for the variation.  For purposes
of applying Section 706(d), the Manager may adopt any method or convention
permitted under applicable Treasury Regulations.  If there is a change in the
Interest of any Member, then for purposes of applying Section 9.2 with respect
to the Fiscal Period ending on the date of change, the hypothetical liquidating
distributions under Section 9.2 shall be made on the basis of the Interests of
each Member as applied before giving effect to such change.

 

9.4                               Curative Allocations.  If the Manager
determines, after consultation with counsel experienced in income tax matters,
that the allocation of any item of LLC income, gain, loss, deduction or credit
is not specified in this Article IX (an “unallocated item”), or that the
allocation of any item of LLC income, gain, loss, deduction or credit hereunder
is clearly inconsistent with the Members’ economic interests in the LLC
(determined by reference to the general principles of Treasury Regulation
Section 1.704-1(b) and the factors set forth in Treasury Regulation
Section 1.704-1(b)(3)(ii)) (a “misallocated item”), then the Manager may
allocate such unallocated items, or reallocate such misallocated items, to
reflect such economic interests; provided that no such allocation shall have any
effect on the amounts distributable to any Member (other than tax
distributions), including the amounts to be distributed upon the complete
liquidation of the LLC.

 

9.5                               Tax Allocations.  For income tax purposes
only, each item of income, gain, loss and deduction of the LLC shall be
allocated in the same manner as the corresponding items of Net Income and Net
Loss and specially allocated items are allocated for Capital Account purposes;
provided that in the case of any asset of the LLC the Carrying Value of which
differs from its adjusted tax basis for U.S. federal income tax purposes,
income, gain, loss and deduction with respect to such asset shall be allocated
solely for income tax purposes in accordance with the principles of
Section 704(c) of the Code so as to take account of the difference between the
Carrying Value and adjusted tax basis of such asset.  Unless otherwise agreed by
the Manager, for purposes of applying the principles of Section 704(c), the LLC
shall use the “traditional method” of Treasury Regulation Section 1.704-3(b).

 

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9.6                               Compliance with Section 704(b) of the Code. 
The allocation provisions contained in this Article IX are intended to comply
with Section 704(b) of the Code and the Treasury Regulations promulgated
thereunder, and shall be interpreted and applied in a manner consistent
therewith.

 

9.7                               Section 754 Election.  The Manager shall cause
the LLC to make an election under Section 754 of the Code effective for the
taxable year in which the Effective Time occurs upon the timely request of
Theravance Biopharma.  In the event of an adjustment to the adjusted tax basis
of any LLC asset under Code Section 734(b) or Code Section 743(b) pursuant to a
Section 754 election by the LLC, subsequent allocations of tax items shall
reflect such adjustment consistent with the Treasury Regulations promulgated
under Sections 704, 734 and 743 of the Code.

 

ARTICLE X

 

EXPENSES

 

10.1                        Expenses.  All LLC Costs shall be borne by the LLC. 
For the avoidance of doubt, the Capital Contributions paid by the Members
pursuant to Section 4.3, together with the existing cash balance of the LLC, are
intended to provide the LLC with a sufficient cash balance to pay the LLC Costs.

 

ARTICLE XI

 

DISTRIBUTIONS

 

11.1                        Distributions.

 

(a)                                 Except as provided in Section 11.2, the Net
Cash of the LLC as of the end of each Fiscal Quarter (or Interim Period) shall
be distributed to the Members as of the end of such Fiscal Quarter (or Interim
Period).  No Member shall be entitled to any distribution or payment with
respect to such Member’s Interest, except as set forth in this Agreement.

 

(b)                                 Other than distributions pursuant to
Section 11.2 and distributions pursuant to Section 14.4, any distribution of
cash or other assets to the Members pursuant to this Section 11.1 shall be made
in proportion to the Member’s respective LLC Percentage.

 

(c)                                  Except as otherwise provided by law, no
Member shall be required to restore or repay to the LLC any funds properly
distributed to it pursuant to Section 11.1.

 

11.2                        Tax Distributions.  Notwithstanding Section 11.1,
within ninety (90) days of the end of each Fiscal Year, the LLC shall make a
distribution to each Member of any available cash of the LLC (as determined by
the Manager) of an amount equal to the excess of (A) the sum of (i) the product
of (x) the amount of net income and gain taxable at ordinary tax rates allocated
to such Member with respect to its Interest (as shown on Schedule K-1 to the
LLC’s IRS Form 1065) for such Fiscal Year and all prior Fiscal Years and (y) the
maximum marginal rate of federal, state and local income tax applicable to a
corporation subject to tax in the Designated Jurisdiction with respect to such
income or gain, (ii) the product of (x) the amount of net income

 

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and gain taxable at long-term capital gains rates allocated to such Member with
respect to its Interest (as shown on Schedule K-1 to the LLC’s IRS Form 1065)
for such Fiscal Year and all prior Fiscal Years and (y) the maximum marginal
rate of federal, state and local income tax applicable to a corporation subject
to tax in the Designated Jurisdiction with respect to such income or gain and,
(iii) in the event of allocation by the LLC of net income or gain taxable at a
rate other than the ordinary or long-term capital gains rates contemplated in
clauses (i) and (ii) above, the product of (x) the amount of such net income and
gain taxable at such other rate allocated to such Member with respect to its
Interest (as shown on Schedule K-1 to the LLC’s IRS Form 1065) for such Fiscal
Year and all prior Fiscal Years and (y) the maximum marginal rate of federal,
state and local income tax applicable to a corporation subject to tax in the
Designated Jurisdiction with respect to such income or gain, over (B) the
cumulative cash distributions previously made to such Member with respect to its
Interest pursuant to this Section 11.2 and Section 11.1(b) during such Fiscal
Year and all prior Fiscal Years.  The determination of the tax rates to be used
for purposes of the preceding sentence shall be made by the Manager in its good
faith discretion after consulting with the LLC’s tax advisors, taking into
account among other things changes in applicable tax rates over the relevant
period, the deductibility of state and local taxes and any limitations on the
ability of an individual to deduct any items of expense or loss under United
States federal income tax principles.  For the avoidance of doubt, the
references to “net income and gain” in clauses (A)(i)(x), (A)(ii)(x), and
(A)(iii)(x) above shall mean that amount of such gross income and gain of the
LLC allocated to such Member with respect to its Interest for all such Fiscal
Years reduced by the gross amount of loss and deduction allocated to such Member
with respect to its Interest for all such Fiscal Years that is available as an
offset to such income and gain.  Without prejudice to the foregoing, the LLC may
make a distribution out of any available cash of the LLC (as determined by the
Manager) to each Member as soon as practicable following the close of each
Estimated Tax Period of each Fiscal Year in amounts equal to the estimated tax
liability of each Member relating to such Estimated Tax Period (as estimated by
the Manager in its good faith discretion after consulting with the LLC’s tax
advisors and based on the results of such quarter and using the methodology and
assumptions described in the preceding sentences).

 

11.3                        No Other Withdrawals.  Except as expressly provided
in this Agreement, no withdrawals or distributions shall be required or
permitted.

 

11.4                        Distribution Limitations.  Notwithstanding any
provision to the contrary contained in this Agreement, the LLC shall not make a
distribution to any Member on account of its Interest if such distribution would
violate the Act or other applicable law or breach any contract or agreement to
which the LLC is a party.

 

ARTICLE XII

 

TRANSFER OF MEMBERSHIP; OTHER MATTERS

 

12.1                        Transfer.

 

(a)                                 Transfer of Class A Units.  No holder of
Class A Units may Transfer all or any portion of its Interest with respect to
the Class A Units other than to (x) GSK or its Affiliates or (y) such holder’s
direct or indirect wholly-owned subsidiaries or successors to all or

 

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substantially all of the assets of such holder whether by merger, sale of stock,
sale of assets or other similar transaction, provided that such transfer
(i) does not result in a violation of the Securities Act or the Securities
Exchange Act, and (ii) is in accordance with the other applicable provisions of
this Article XII.

 

(b)                                 Transfer of Class C Units and Class B
Units.  A holder of Class B Units or Class C Units may freely Transfer all or
any portion of its Interest with respect to the Class B Units or Class C Units,
respectively, provided that such Transfer (i) does not result in a violation of
the Securities Act or the Securities Exchange Act, and (ii) is in accordance
with the other applicable provisions of this Article XII.  For the avoidance of
doubt, this Section 12.1(b) shall not limit the effect of the second proviso
clause beginning “provided, further however,” of Section 5.4(c).

 

12.2                        Transfer Void.  Any Transfer or attempted Transfer
of an Interest in contravention of this Agreement shall, to the fullest extent
permitted by law, be absolutely null and void ab initio and of no force or
effect, on or against the LLC, any Member, any creditor of the LLC or any
claimant against the LLC and may be enjoined, and shall not be recorded or
otherwise registered on the books and records of the LLC.  No distributions of
cash or property of the LLC shall be made to any transferee of any Interest
Transferred in violation hereof.  The Transfer or attempted Transfer of any
Interest in violation hereof shall not affect the beneficial ownership of such
Interest, and, notwithstanding such Transfer or attempted Transfer, the Member
making such prohibited Transfer or attempted Transfer shall retain the right to
vote, if any, and the right to receive distributions with respect to such
Interest.

 

12.3                        Effect of Assignment.  Following a Transfer of an
Interest that is permitted under this Article XII, the assignee of such Interest
(i) shall be a mere assignee, holding only the economic interest of the
transferring Member and shall have no other rights (including, without
limitation, voting or information rights) unless and until such assignee is
admitted to the LLC as a member of the LLC in accordance with Section 12.9,
(ii) shall be treated as having made all of the Capital Contributions in respect
of, and received all of the distributions received in respect of, such Interest,
(iii) shall succeed to the Capital Account associated with such Interest and
(iv) shall receive allocations and distributions under Articles IX and XI in
respect of such Interest as if such transferee were a Member.  For the avoidance
of doubt, with respect to the Theravance Biopharma Transfer, Theravance
Biopharma shall be treated as having made all of the Capital Contributions in
respect of such Interest and shall succeed to the Capital Account associated
with such Interest.  The Manager shall cause Exhibit A to be appropriately
amended to reflect any Transfer of an Interest.

 

12.4                        Legends.

 

(a)                                 In the event the Units become certificated
Units, any certificate representing Units shall be endorsed with the following
legend, as well as with any legends as may be required by applicable federal and
state securities laws:

 

“THE SALE, PLEDGE, HYPOTHECATION, ASSIGNMENT OR TRANSFER OF THE UNITS
REPRESENTED BY THIS CERTIFICATE IS SUBJECT TO THE TERMS AND CONDITIONS OF A
CERTAIN WRITTEN AGREEMENT

 

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BETWEEN THE REGISTERED HOLDERS OF THE UNITS OF THE LLC (OR THE PREDECESSOR IN
INTEREST TO THE UNITS).  SUCH AGREEMENT RESTRICTS THE TRANSFER OF UNITS.  SUCH
AGREEMENT CONTAINS PROVISIONS REGARDING THE VOTING OF THE UNITS REPRESENTED BY
THIS CERTIFICATE.  COPIES OF SUCH AGREEMENT MAY BE OBTAINED FROM THE ISSUER UPON
WRITTEN REQUEST.  BY ACCEPTING ANY INTEREST IN SUCH UNITS THE PERSON ACCEPTING
SUCH INTEREST SHALL BE DEEMED TO AGREE TO AND SHALL BECOME BOUND BY ALL THE
PROVISIONS OF SUCH AGREEMENT.”

 

(b)           Any certificate issued at any time in exchange or substitution for
any certificate bearing such legends shall also bear such legends, unless the
Units represented thereby are no longer subject to the provisions of this
Agreement or, in the opinion of the LLC (with advice from counsel to the LLC, as
the LLC may deem appropriate), the restrictions imposed under the Securities Act
or state securities laws are no longer applicable, in which case the applicable
legend (or legends) may be removed.

 

12.5        Publicly Traded Partnership Limitations.  Notwithstanding any other
provision of this Agreement, no Transfer shall be permitted if (i) the Manager
determines in its sole discretion that such transaction will either cause the
LLC to be characterized as a “publicly traded partnership” or will materially
increase the risk that the LLC will be so characterized or (ii) such Transfer
would occur in a transaction registered or required to be registered under the
Securities Act.  For purposes of this Section 12.5, the phrase “publicly traded
partnership” shall have the meanings set forth in Section 7704(b) and 469(k) of
the Code.  In particular and without limiting the foregoing, no Transfer shall
be permitted, given effect or otherwise recognized, and such Transfer (or
purported Transfer) shall, to the fullest extent permitted by law, be void ab
initio, if at the time of such Transfer (or as a result of such Transfer) Units
are (or would become) traded on an “established securities market” (within the
meaning of Treasury Regulation Section 1.7704-1(b)) or are (or would become)
“readily tradable on a secondary market or the equivalent thereof” (within the
meaning of Treasury Regulation Section 1.7704-1(c)).

 

12.6        Effective Date.  Any Transfer in compliance with this Article XII
shall be deemed effective on the first date as of which the relevant
requirements of this Agreement have been satisfied.

 

12.7        Redemption.  The Units shall not be redeemable at the option of the
holder thereof or otherwise.

 

12.8        Assignment of Reverted Drug Programs.  Theravance and the LLC shall
assign to Theravance Biopharma all rights to any Assigned Product reverted to
Theravance or the LLC pursuant to the GSK Agreements, and following such
assignment Theravance Biopharma shall be free to pursue the development of any
such Assigned Product to the extent permitted under the GSK Agreements and
without any obligations to the LLC, to any Member or to any other Person bound
by this Agreement except as otherwise provided in the GSK Agreement.

 

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12.9        Admission of Permitted Assignee as a Member.  Any assignee of an
Interest permitted in accordance with the terms and conditions of this Agreement
shall, upon its request, be admitted as a substitute Member by the Manager. If a
Member assigns its entire Interest pursuant to this Article XII in accordance
with the requirements of this Agreement, such admission shall be deemed
effective immediately prior to such assignment, and immediately following such
admission, such assignor Member shall cease to be a member of the LLC. The
Manager shall cause Exhibit A to be appropriately amended to reflect any
admission of a new Member and cessation of an existing Member.

 

12.10      Transfer to Theravance Biopharma at Effective Time; Admission of
Theravance Biopharma at Effective Time.  Notwithstanding any other provision of
this Agreement, at the Effective Time:

 

(a)           Theravance shall (and, effective automatically upon the Effective
Time, hereby does) Transfer to Theravance Biopharma all two thousand one hundred
twenty-five (2,125) Class B Units, six thousand three hundred seventy-five
(6,375) Class C Units and all of the respective rights and responsibilities
appurtenant thereto hereunder, including (i) with respect to a Member (but not
an assignee), the right, if any, to vote to the extent set forth herein,
(ii) the right to have a Capital Account maintained for such Member (or
assignee), (iii) the right to receive allocations of Net Income and Net Losses
pursuant to Article IX, and (iv) the right to receive distributions of cash or
property from the LLC;

 

(b)           Theravance Biopharma shall be admitted as a Member pursuant to
Section 12.9; and

 

(c)           Theravance Biopharma shall execute and deliver such instruments of
transfer as shall be necessary to evidence and effect such Transfer.

 

ARTICLE XIII

 

INDEMNIFICATION AND LIMITATION OF LIABILITY

 

13.1        Indemnification.

 

(a)           For purposes of this Section 13.1(a), (i) “agent” means the
Manager, any former Manager, Officer, any former Officer, any direct or indirect
subsidiary of the LLC or any Affiliate, officer, director or employee of the
foregoing; (ii) “proceeding” means any threatened, pending or completed action
or proceeding, whether civil, criminal, administrative, legislative or
investigative; (iii) “Member” means each Member and any former Member, any
direct or indirect subsidiary of such Member or any Affiliate, officer, director
or employee of the foregoing and (iv) “expenses” include, without limitation,
reasonable attorneys’ fees and other expenses of establishing a right of
indemnification under this Section 13.1(a).  The LLC shall, (i) to the fullest
extent permitted under the DGCL (as if the LLC were a Delaware corporation and
agent was a director or officer of a Delaware corporation), indemnify and hold
harmless each agent (and his heirs and legal and personal representatives) and
(ii) to the fullest extent permitted under the Act, indemnify and hold harmless
each Member (and its successors and permitted assigns), in each case against
losses and damages arising out of liabilities or expenses incurred

 

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by him as a result of serving in the capacity by reason of which such Person is
deemed to be an “agent” or Member pursuant to this subsection (a), regardless of
whether the agent or Member is or continues to serve in such capacity at the
time any such liability or expense is paid.  Without limiting the generality of
the foregoing, the LLC hereby agrees (i) to the fullest extent permitted under
the DGCL (as if the LLC were a Delaware corporation and the agent was a director
or officer of a Delaware corporation) to indemnify each agent (and his heirs and
legal and personal representatives) and (ii) to the fullest extent permitted
under the Act, indemnify and hold harmless each Member (and its successors and
permitted assigns), and to save and hold such Person harmless, from and in
respect of all (1) fees, costs and expenses reasonably incurred in connection
with or resulting from any demand, claim, action or proceeding against such
agent (and his heirs and legal and personal representatives) or such Member (and
its successors and permitted assigns) or the LLC that arises out of or in any
way relates to the agent’s or Member’s service in the capacity by reason of
which such Person is deemed to be an “agent” or “Member” pursuant to this
subsection (a), and (2) such demands, claims, actions and proceedings and any
losses or damages resulting therefrom, including judgments, fines and amounts
paid in settlement or compromise of any such demand, claim, action or
proceeding.  Notwithstanding the foregoing, the LLC shall not indemnify any
agent (or his heirs or legal or personal representatives) or Member (or its
successors or permitted assigns) for (i) losses, damages or expenses incurred
with respect to any demand, claim, action or proceeding if such Person’s conduct
was undertaken in bad faith, recklessly or with gross negligence or if such
Person’s conduct or its acts or omissions constituted fraud, intentional
wrongdoing, or breach of this Agreement (including, in the case of Theravance or
the Manager, the failure of Theravance or the Manager to comply with its
fiduciary duties under Section 5.2) or any other agreement, including the GSK
Agreements, as determined by a court of competent jurisdiction pursuant to
Section 15.10, or (ii) any liability arising by reason of any act or omission of
an agent or Member subsequent to his ceasing to be an agent or Member, as
applicable, subsequent to the termination of the LLC.  The termination of any
proceeding by a judgment, order, settlement, conviction or upon a plea of nolo
contendere, or its equivalent, shall not, of itself, create a presumption that
the agent’s or Member’s conduct was undertaken in bad faith, recklessly or with
gross negligence or that such Person’s conduct or its acts or omissions
constituted fraud, intentional wrongdoing or breach of this Agreement
(including, in the case of Theravance or the Manager, the failure of Theravance
or the Manager to comply with its fiduciary duties under Section 5.2) or any
other agreement, including the GSK Agreements.  The LLC shall be required to
advance the expenses incurred by any Person indemnified hereunder in connection
with any proceeding in advance of the final disposition or other termination of
such proceeding upon receipt of an undertaking by or on behalf of such Person to
repay such payment if there shall be an adjudication or determination that such
agent is not entitled to indemnification as provided herein.

 

(b)           The indemnification accorded to an agent (or his heirs or legal or
personal representatives) under Section 13.1(a) shall be made solely out of the
assets of the LLC, and no Member, Manager or Officer shall have any personal
liability or other obligation therefor.  Nothing in Section 13.1(a) shall be
deemed to require any Member to make any additional Capital Contribution.

 

13.2        Exculpation.  For purposes of this Section 13.2, the terms “Member”
and “agent” shall have the meanings assigned to such terms in Section 13.1(a). 
No agent shall be liable to the LLC or any Member or any other Person who is
bound by this Agreement for (a) honest

 

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mistakes in judgment, or for action or inaction, taken reasonably and in good
faith and for a purpose that was reasonably believed to be in the best interests
of the LLC or (b) losses sustained or liabilities incurred as a result of any
act or omission of such agent if such agent’s conduct were not undertaken in bad
faith, recklessly or with gross negligence or if such agent’s conduct and its
acts or omissions did not constitute fraud, intentional wrongdoing or breach of
this Agreement (including, in the case of Theravance or the Manager, the failure
of Theravance or the Manager to comply with its fiduciary duties under
Section 5.2) or any other agreement, including the GSK Agreements.  To the
fullest extent permitted under the Act, no Member shall be liable to the LLC or
any Member or any other Person who is bound by this Agreement for any action or
inaction taken by such Member or for any losses sustained or liabilities
incurred as a result of any act or omission of such Member.  Each agent and
Member may consult with counsel, accountants and other professionals in respect
of LLC affairs and shall be fully protected and justified in acting, or failing
to act, if such action or failure to act is in accordance with the reasonable
advice or opinion of such counsel, accountant or other professional and if such
counsel, accountant or other professional shall have been selected with
reasonable care.  Notwithstanding the foregoing, the provisions of this
Section 13.2 shall not relieve any Person of liability arising by reason of such
Person’s acting in bad faith, recklessly or with gross negligence, or if such
Person’s conduct in the performance of its duties hereunder, or its acts or
omissions, constitute fraud, intentional wrongdoing, or breach of this Agreement
(including, in the case of Theravance or the Manager, the failure of Theravance
or the Manager to comply with its fiduciary duties under Section 5.2) or any
other agreement, including the GSK Agreements.  This Agreement shall be
construed to give effect to the provisions of this Section 13.2 to the fullest
extent permitted by law.

 

13.3        Limitation of Liability.  Notwithstanding anything to the contrary
herein contained, the debts, obligations and liabilities of the LLC shall be
solely the debts, obligations and liabilities of the LLC and no Member, Manager
or Officer shall be obligated personally for any such debt, obligation or
liability of the LLC solely by reason of being a Member, Manager or Officer.

 

ARTICLE XIV

 

DISSOLUTION AND TERMINATION

 

14.1        Dissolution.  The LLC shall be dissolved, its assets disposed of and
its affairs wound up upon the first to occur of the following:

 

(a)           the consent of a Majority in Interest of the Class A Members, a
Majority in Interest of the Class B Members and a Majority in Interest of the
Class C Members; or

 

(b)           the entry of a decree of judicial dissolution under the Act; or

 

(c)           at any time there are no members of the LLC, unless the LLC is
continued without dissolution in accordance with this Agreement or the Act.

 

Except as otherwise provided herein, the death, bankruptcy, incompetency,
retirement, resignation, expulsion or dissolution of a Member, or the occurrence
of any event that terminates

 

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the continued membership of a Member in the LLC, shall not, in and of itself,
dissolve or terminate the LLC.  Notwithstanding any other provision of this
Agreement, the bankruptcy (as defined in Sections 18-101(1) and 18-304 of the
Act) of a Member will not cause that Member to cease to be a member of the LLC,
and upon the occurrence of such an event, the business of the LLC shall continue
without dissolution.

 

14.2        Authority to Wind Up.  Upon the dissolution of the LLC as set forth
in Section 14.1, the Manager shall have all necessary power and authority
required to marshal the assets of the LLC, to satisfy the LLC’s creditors, to
distribute assets and otherwise wind up the business and affairs of the LLC.  In
particular, the Manager shall have the authority to continue to conduct the
business and affairs of the LLC insofar as such continued operation remains
consistent, in the reasonably judgment of the Manager, with the orderly winding
up of the LLC.

 

14.3        Winding Up and Certificate of Cancellation.  The winding up of the
LLC shall be completed when all debts, liabilities and obligations of the LLC
have been paid and discharged or reasonably adequate provision therefor has been
made, and all of the remaining property and assets of the LLC have been
distributed to the Members.

 

14.4        Distribution of Assets.  Upon dissolution of the LLC, the affairs of
the LLC shall be wound up and the LLC shall be liquidated by the Manager.  The
assets of the LLC shall be distributed as follows in accordance with the Act:

 

(a)           To creditors of the LLC, including to the payment of the expenses
of the dissolution, winding up and liquidation of the LLC and, in accordance
with the terms agreed among them or otherwise on a pro rata basis (based on
amounts owed to them), Members who are creditors (other than in respect of
distributions owing to them or to former Members hereunder), to the extent
otherwise permitted by law, in satisfaction of the liabilities of the LLC
(whether by payment or the making of reasonable provision for payment thereof,
including by establishing reserves, in amounts established by the Manager to
meet other liabilities of the LLC, including contingent, conditional and
unmatured liabilities (other than liabilities to the Members or former Members
in respect of distributions owing to them hereunder));

 

(b)           The remaining assets of the LLC shall be applied and distributed
to the Members in proportion to their respective LLC Percentages.

 

(c)           The distribution of cash, securities and other property to a
Member in accordance with the provisions of this Section 14.4 shall constitute a
complete return to the Member of its Capital Contributions and a complete
distribution to the Member of its Interest and all the LLC’s property, and shall
constitute a compromise to which all Members have consented within the meaning
of the Act.  If such cash, securities and other property are insufficient to
return such Member’s Capital Contributions or returns thereon, the Member shall
have no recourse against the Manager, other Members or Officers.  If any amounts
distributable to the Members are other than cash, their value shall be deemed to
be the fair market value as determined in good faith by the Manager.

 

14.5        Contingent Distribution.  For the avoidance of doubt, if any portion
of the amount distributable to the Members pursuant to Section 14.4(b) is placed
into escrow and/or is

 

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payable to such holders subject to contingencies, such dissolution or
termination shall be effected such that the portion of such amount that is
placed in escrow and/or subject to any contingencies (the “Contingent
Distribution”) shall be allocated to the Members in accordance with this
Section 14.5 as if all of consideration ultimately payable in the transaction,
including the Contingent Distribution, is paid without restrictions at the time
of closing of such dissolution or termination (so that the Contingent
Distribution shall be allocated among the Members pro rata based on the amount
of such consideration otherwise payable to each Member pursuant to this
Section 14.5).  Each Member agrees to take such actions as may be required,
necessary or advisable to effect the intent of this Section 14.5.

 

ARTICLE XV

 

MISCELLANEOUS

 

15.1        Amendment.

 

(a)           Except as expressly set forth herein (including without
limitation, Section 5.4), this Agreement may be amended, revised and modified
and the observance of any term hereof may be waived (either generally or in a
particular instance and either retroactively or prospectively), including any
amendment, revision, modification or waiver of or to this Agreement by merger,
reorganization, transfer of assets, consolidation, dissolution, issuance or sale
of securities or otherwise, only with the consent of a Majority in Interest of
the Class A Members, provided, however, that any amendment, revision,
modification or waiver of or to this Agreement, including any amendment,
revision, modification or waiver of or to this Agreement by merger,
reorganization, transfer of assets, consolidation, dissolution, issuance or sale
of securities or otherwise, directly or indirectly adversely affecting the
interest of the Class B Members or the Class C Members in the Assigned Drug
Programs or Assigned Products (including, for the avoidance of doubt, any
amendment to the rights, preferences, privileges and obligations of Theravance,
the LLC, the Manager or the Class A Units under this Agreement having such an
effect) or directly or indirectly adversely affecting the rights, preferences,
privileges or obligations of the Class B Units under this Agreement may be made
only with the consent of a Majority in Interest of the Class B Members.  Any
amendment, revision, modification or waiver so effected shall be binding upon
all the Parties hereto.

 

(b)           No Party shall, without a Majority in Interest of the Class A
Members and a Majority in Interests of the Class B Members:

 

(i)            by amendment of this Agreement or through any reorganization,
recapitalization, transfer of assets, consolidation, merger, dissolution, issue
or sale of securities or any other voluntary action, avoid or seek to avoid, or
consummate or agree to consummate any such action that has the effect of
avoiding, the observance or performance of any of the terms to be observed or
performed under this Agreement by the LLC, but will at all times in good faith
assist in the carrying out of all the provisions of this Agreement; or

 

(ii)           amend, alter or repeal this Section 15.1 of this Agreement (or
any other provision of this Agreement having the effect of amending, altering or
repealing this Section 15.1).

 

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(c)           Notwithstanding the foregoing provisions, the Manager may amend
and modify the provisions of this Agreement (including Article IX) and Exhibits
A and B hereto to the extent necessary to reflect the admission, substitution or
removal of any Member permitted under this Agreement and the election,
designation, removal, vacancy or resignation of any Manager (in each case
subject to the approval of any such action by the requisite vote of Members
entitled to vote pursuant to this Agreement).  Furthermore, the Manager may
amend this Agreement, without the consent of the Members, (i) to make a change
that is reasonably necessary to cure any ambiguity or inconsistency and to make
changes to satisfy any requirements, conditions or guidelines contained in any
opinion, directive, order, ruling, regulation or statute of any governmental
body which will not be inconsistent with this Agreement, in both cases, subject
to the requirement that no Member be materially and adversely affected; or
(ii) to prevent any material and adverse effect to the LLC or any Member arising
from the application of legal restrictions to any Member, subject to the
requirement that no Member be adversely affected without its consent.

 

(d)           No Party shall amend, revise, modify or waive this Agreement,
including by merger, reorganization, transfer of assets, consolidation,
dissolution, issuance or sale of securities or otherwise, in a manner that,
directly or indirectly, has an adverse effect on the rights, preferences,
privileges of or obligations of the Class C Units under this Agreement or
applicable law without the consent of a Majority in Interest of the Class C
Members.

 

(e)           Promptly after entering into any amendment pursuant to this
Section 15.1, the Manager shall provide the Members a copy of such amendment.

 

(f)            Section 3.8 of this Agreement may not be amended without the
consent of Theravance Biopharma.

 

15.2        Power of Attorney.

 

(a)           By signing this Agreement, each Member hereby makes, constitutes
and appoints the Manager with full power of substitution and resubstitution, its
true and lawful agent or agents and attorney- or attorneys-in-fact for it and in
its name, place and stead, to sign, execute, certify, acknowledge, file and
record (i) the Certificate, (ii) all instruments amending, restating or
canceling the Certificate, as the same may hereafter be amended or restated,
pursuant to the Act or this Agreement, and (iii) such other agreements,
instruments, elections or documents (a) that may be necessary to reflect the
exercise by a Member of any of the powers granted to it under this Agreement,
and (b) that may be required of the LLC or of the Members by the laws of
Delaware or any other jurisdiction.  Each Member authorizes such agent or
attorney-in-fact to take any further action that such agent or attorney-in-fact
shall consider necessary in connection with any of the foregoing, hereby giving
such agent or attorney-in-fact full power and authority to do and perform each
and every act or thing whatsoever requisite or advisable to be done in and about
the foregoing as fully as such Member might or could do if personally present,
and hereby ratifying and confirming all that such agent or attorney-in-fact
shall lawfully do or cause to be done by virtue hereof.  The Manager shall
provide to each Member copies of all documents executed pursuant to the power of
attorney contained in this Section 15.2.

 

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(b)           The power of attorney granted pursuant to this Section 15.2:

 

(i)            is a special power of attorney coupled with an interest and is
irrevocable;

 

(ii)           may be exercised by such attorney-in-fact by listing all of the
Members executing any agreement, certificate, instrument or document with the
single signature of such attorney-in-fact acting as attorney-in-fact for all of
them; and

 

(iii)          shall survive the assignment by a Member of its Interest, except
that where the assignee thereof is admitted as a Member, the power of attorney
shall survive such assignment as to the assignor Member for the sole purpose of
enabling such attorney-in-fact to execute, acknowledge and file any such
agreement, certificate, instrument or document as is necessary to effect such
admission.

 

15.3        Withholding.  The LLC shall at all times be entitled to make
payments with respect to any Member in amounts required to discharge any
obligation of the LLC to withhold or make payments to any governmental authority
with respect to any federal, state, local, or other jurisdictional tax liability
of such Member arising as a result of such Member’s Interest.  To the extent
each such payment satisfies an obligation of the LLC to withhold, with respect
to any distribution to a Member on which the LLC did not withhold or with
respect to any Member’s allocable share of the income of the LLC, each such
payment shall be deemed to be a loan by the LLC to such Member (which loan shall
be deemed to be immediately due and payable) and shall not be deemed a
distribution to such Member.  The amount of such payments made with respect to
such Member, plus interest, on each such amount from the date of each such
payment until such amount is repaid to the LLC at an interest rate per annum
equal to the prime rate published in the Wall Street Journal on the date of such
payment by the LLC with respect to such Member, shall be repaid to the LLC by
(a) deduction from any cash distributions made to such Member pursuant to this
Agreement, or (b) earlier payment by such Member to the LLC, in each case as
determined by the LLC in its discretion.  The LLC may, in its discretion, defer
making distributions to any Member owing amounts to the LLC pursuant to this
Section 15.3 until such amounts are paid to the LLC and shall in addition
exercise any other rights of a creditor with respect to such amounts.  Each
Member agrees to indemnify and hold harmless the LLC and each of the Members,
from and against liability for taxes, interest, or penalties which may be
asserted by reason of the failure to deduct and withhold tax on amounts
distributable or allocable to said Member.  Any amount payable as indemnity
hereunder by a Member shall be paid promptly to the LLC upon request for such
payment from the LLC, and if not so paid, the LLC shall be entitled to claim
against and deduct from the Capital Account of, or from any distribution due to,
the affected Member for all such amounts.

 

15.4        Apportionment of Amounts Withheld at the Source or Paid by the LLC.

 

(a)           If the LLC receives securities disposition proceeds or other
income with respect to which taxes have been withheld at the source or with
respect to which the LLC makes payments to any taxing authority, the aggregate
amount of such taxes so withheld or paid shall be deemed for all purposes of
this Agreement to have been received by the LLC and then distributed by the LLC
to and among the Members based on the amount of such withholding or

 

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other taxes attributable to each Member, as determined by the Manager after
consulting with the LLC’s accountants or other advisers, taking into account any
differences in the amount of such withholding or other taxes attributable to
each Member because of such Member’s status, nationality or other
characteristics.  The intent of the preceding sentence is to have the burden of
taxes withheld at the source or paid or reimbursed by the LLC borne by those
Members to which such withholding or other taxes are attributable to the maximum
extent possible.  If the amounts deemed distributed to the Members in accordance
with such sentence do not comport with the provisions of this Agreement relating
to the apportionment of distributions among the Members, then, notwithstanding
such distribution provisions, subsequent distributions to the Members shall be
adjusted in an equitable manner by the Manager to reflect the intent of such
sentence.

 

(b)           If the LLC is required to remit cash to a governmental agency in
respect of a withholding obligation arising from an in-kind distribution by the
LLC or the LLC’s receipt of an in-kind payment, the Manager may cause the LLC to
sell an appropriate portion of the property at issue and, to the extent
permitted by applicable law (as determined by the Manager), any resulting income
or gain shall be allocated solely for income tax purposes entirely to the Member
or Members in respect of which such withholding obligation arises (in such
proportion as the Manager shall determine in its reasonable discretion).

 

15.5        Notice to and Consent of Members.  By executing this Agreement, each
of the parties hereto acknowledges that it has actual notice of and consents to
(a) all of the provisions hereof (including the restrictions on Transfer), and
(b) all of the provisions of the Certificate.

 

15.6        Further Assurances.  The parties agree to execute and deliver any
further instruments or documents and perform any additional acts which are or
may become necessary to effectuate and carry on the LLC created by this
Agreement.

 

15.7        Binding Effect.  Subject to the restrictions on Transfer set forth
in this Agreement, this Agreement shall be binding on and inure to the benefit
of the Members and their respective transferees, successors, permitted assigns
and legal representatives.  If Theravance or the Manager or any of their
respective successors or assigns shall (i) consolidate with or merge into any
other Person and shall not be the continuing or surviving Person of such
consolidation or merger or (ii) sell, lease, license, transfer or otherwise
dispose of all or substantially all of its business or assets to any Person,
then, in each case, proper provision shall be made so that such Persons assume
the obligations of Theravance and the Manager hereunder.

 

15.8        Governing Law.  This Agreement shall be governed by and construed
under the laws of the State of Delaware as applied to agreements among Delaware
residents entered into and to be performed entirely within Delaware.

 

15.9        Title to LLC Property.  Legal title to all property of the LLC will
be held and conveyed in the name of the LLC.

 

15.10      Dispute Resolution.

 

(a)           In the event of any dispute, controversy or claim arising under or
relating to this Agreement (a “Claim”), the party asserting the Claim (the
“Claimant”) shall give written notice (a “Claim Notice”) to the other parties to
this Agreement (the “Respondents”).

 

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(b)           The Claim Notice shall specify in reasonable detail the basis of
the Claim, including (i) the provisions of this Agreement that it alleges have
been breached and (ii) to the extent known to it, the factual basis of such
alleged breach.  The Claim Notice need not specify the factual basis of such
alleged breach to the extent such facts are not available to Claimant due to
confidentiality or other restrictions applicable to the Assigned Drug Programs
or Assigned Products or to the extent any Respondent has or could reasonably
obtain access to such facts, but has withheld them from Claimant (without regard
to any confidentiality obligation or other restriction on disclosure).

 

(c)           The parties to the dispute (i.e., the Claimant and the
Respondents) shall negotiate in good faith to seek to achieve a mutually
agreeable resolution of the Claim for fifteen (15) business days after receipt
of such Claim by Respondents, or such longer period as they shall mutually
agree.  Any such resolution shall be set forth in a written agreement signed by
all parties to the dispute.

 

(d)           If the parties to the dispute do not achieve a mutually agreeable
resolution within such time period, the sole recourse of the Claimant to resolve
the Claim shall be through binding arbitration in accordance with this Agreement
(“Arbitration”).  To initiate such arbitration, the Claimant shall furnish the
Respondents written notice (“Arbitration Notice”) of its intent to pursue
arbitration within fifteen (15) business days after the end of such time period.

 

(e)           Each party to the dispute shall (i) take all reasonable steps
necessary or advisable in order to properly submit the Claim to Arbitration;
(ii) raise no objection to the submission of the Claim to Arbitration;
(iii) irrevocably waive, to the fullest extent permitted by law, any objection
such party has, or may have, to the submission of the Claim to Arbitration;
(iv) irrevocably waive, to the fullest extent permitted by law, any right to
have the Claim submitted for resolution in any jurisdiction or venue other than
the Arbitration; (v) irrevocably waive, to the fullest extent permitted by law,
any and all rights to have the Claim decided by a jury; and (vi) irrevocably
waive, to the fullest extent permitted by law, any and all rights to any appeal
of the ruling or award of the Arbitrator(s).

 

(f)            The scope of the arbitration shall be limited solely to the Claim
in accordance with this Agreement (including this dispute resolution process). 
No other matter may be brought before the Arbitration.

 

(g)           The Arbitration shall be conducted before a former member of the
Delaware Court of Chancery or the Delaware Supreme Court selected in good faith
by mutual agreement of the Parties within fifteen (15) business days after the
date the Arbitration Notice is delivered by the Claimant, provided that if the
Parties cannot reach such mutual agreement within such period, then any party
may petition the Delaware Court of Chancery to appoint an arbitrator who shall
be a former member of the Delaware Court of Chancery or the Delaware Supreme
Court.  If no former member of the Court is willing or able to serve in such
capacity, then within ten (10) business days of learning of such unwillingness
or unavailability, each party shall select one person to act as arbitrator from
a list of arbitrator candidates provided by JAMS, and, within five (5) business
days after their selection, the two so selected shall select a third arbitrator
(all three collectively, the “Arbitrators”). If the Arbitrators selected by the
parties are unable or fail to agree upon the third Arbitrator within the
allotted time, the third Arbitrator shall

 

49

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be appointed by JAMS. All Arbitrators shall serve as neutral, independent and
impartial arbitrators.

 

(h)           Subject to the availability of the Arbitrator(s), the parties
shall use their commercially reasonable best efforts to complete the Arbitration
within ninety (90) days after the Arbitrator(s) is/are appointed (or as promptly
thereafter as possible), on a schedule to be negotiated in good faith among the
Parties.

 

(i)            This arbitration provision (including the validity and
applicability of the agreement to arbitrate, the conduct of any arbitration, the
enforcement of any arbitration award made hereunder and any other questions of
arbitration law or procedure arising hereunder) and its interpretation, and any
Claim, shall be governed by and construed in accordance with the internal laws
of the State of Delaware, without giving effect to any choice or conflict of law
provision or rule (whether of the State of Delaware or any other jurisdiction)
that would cause the application of laws of any jurisdictions other than those
of the State of Delaware.  The location of any arbitration shall be Wilmington,
Delaware or such other location as mutually agreed to by the parties.

 

(j)            The Parties agree that, except as otherwise provided herein, the
Arbitration shall proceed in accordance with the JAMS Streamlined Arbitration
Rules and Procedures (“JAMS Rules”) effective July 15, 2009, unless the Parties
mutually agree to proceed under different rules and procedures.  For the
avoidance of doubt, to the extent any rule or procedure set forth in the JAMS
Rules conflicts with this Agreement, this Agreement supersedes and trumps any
such conflict.  Unless the Parties mutually agree, the following Jams
Rules shall not apply to the Arbitration:  Rule 3 and Rule 19(f). 
Rule 15(a)(3) shall be limited to exclude exhibits intended to be used solely on
cross examination.  Rule 16 shall be further limited such that any subpoena
shall be issued only upon prior order of the Arbitrator(s) and upon good cause
shown.

 

(k)           The Claimant shall have the burden of proving any Claim by a
preponderance of the evidence, provided that if evidence is not available to
Claimants (or any of its parent entities or other Affiliates) due to
confidentiality or other restrictions applicable to the Assigned Drug Programs
or Assigned Products or the Respondents have obtained or reasonably could obtain
access to facts that are relevant to the Arbitration, but have not disclosed
them to the Claimant (without regard to any confidentiality obligation or other
restriction on disclosure), then the allegations set forth in the Claim Notice
shall be taken as true by the Arbitrator and Respondents shall have the burden
of refuting such Claim by a preponderance of the evidence.

 

(l)            The Arbitrator(s) shall be entitled to award any legal and
equitable remedies he, she or they deem appropriate in resolving any Claim,
provided that no remedy shall violate or give rise to a right to terminate the
GSK Agreements.

 

(m)          A party to a dispute liable to pay a damage remedy shall pay such
amount within ten (10) business days after the ruling by the Arbitrator(s).  If
any such party (other than the LLC) is liable to pay a damage remedy to another
party, it shall pay such amount directly to the party entitled to receive such
payment and not to the LLC as a capital contribution.

 

50

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Theravance shall be required to pay on behalf of the Manager any damage remedy
to which the Manager is found liable.

 

(n)           An Arbitration award, if any, (i) shall be the sole and exclusive
remedy with respect to a Claim by a party to a dispute, and (ii) shall be final,
non-appealable and binding on the parties to the dispute and may be entered as a
judgment in any court of competent jurisdiction as described more fully below. 
The parties to this Agreement further agree that any claim, cause of action or
proceeding relating to any arbitration sought, compelled or performed hereunder
will be brought and pursued only in the U.S. District Court for the District of
Delaware or, solely in the case that such federal court does not have
jurisdiction, in any Delaware State court (collectively, the “Delaware
Courts”).  The parties to this Agreement submit to the exclusive jurisdiction
and venue of the Delaware Courts for such purposes, except that any confirmed
arbitration award may be enforced in any court having jurisdiction over a party
or, to the extent of any in rem action, any of its assets.  The parties to this
Agreement further irrevocably waive any objection to the laying of the venue of
any such proceeding in the Delaware Courts, any claim that any such proceeding
has been brought in an inconvenient or inappropriate forum and any right to a
jury trial with regard to any such proceeding.  The relationship between the
parties to any dispute arising under this Agreement shall be deemed commercial
in nature, and the Claim shall be deemed commercial.

 

(o)           The parties to this Agreement agree that, subject to any
non-waivable disclosure obligations under applicable law, the Arbitration, and
all matters relating thereto or arising thereunder, including, without
limitation, the existence of any Claim, the proceeding and all of its elements
(including any pleadings, briefs or other documents submitted or exchanged, any
testimony or other oral submissions, any third-party discovery proceedings,
including any discovery obtained pursuant thereto, and any decision of the
Arbitrator(s) or award), shall be kept strictly confidential, and each party
hereby agrees that such information shall not be disclosed beyond:  (i) the
Arbitrator(s); (ii) the participants in the Arbitration and their respective
legal counsel; (iii) those agents assisting the Parties in the preparation or
presentation of the Arbitration; provided such agents are contractually or
legally required to preserve the confidentiality of such information as
contemplated by this Agreement; (iv) other employees or agents of the Parties
with a need to know such information who are contractually required to preserve
the confidentiality of such information as contemplated by this Agreement.  The
parties to this Agreement further agree that they will, to the fullest extent
permitted by law, file under seal any claim, cause of action or proceeding
relating to any arbitration sought, compelled or performed hereunder or any
arbitration ruling or award issued.  Disclosure under this Section 15.10,
including any authorized disclosure by the disclosing party, does not relieve
the receiving party of its obligations of confidentiality generally under this
Agreement.  In no event will the receiving party or its officers, directors,
employees, attorneys, accountants, financial advisors, contractors or agents
oppose an action by the disclosing party to obtain a protective order, order
sealing documents, or other relief requiring that confidential information to be
disclosed shall be treated confidentially in connection with any claim, action
or proceeding.

 

(p)           Each party to a dispute shall pay its own costs and expenses in
any Arbitration, except that the Arbitrator(s) at his, her or their sole
discretion may require the non-prevailing party to the Arbitration to pay the
costs and expenses of the prevailing party.

 

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15.11      Entire Agreement.  This Agreement, the Exhibits and Attachments
hereto, and the portions of the Master Agreement that relate to the LLC
(collectively, the “Entire Agreements”) constitute the entire agreement among
the parties with respect to the subject matter herein.  The Entire Agreements
replace and supersede all prior agreements by and among the Members or any of
them with respect to the subject matter herein.  The Entire Agreements supersede
all prior written and oral statements with respect to the subject matter herein;
and no representation, statement, condition or warranty not contained in the
Entire Agreements with respect to the subject matter herein will be binding on
the Members or the LLC or have any force or effect whatsoever.

 

15.12      Counterparts.  This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.  For the avoidance of
doubt, affirmation or signature of this Agreement or Unit purchase or issuance
agreement by electronic means (an “Electronic Signature”) shall, to the extent
permitted by law, constitute the execution and delivery of a counterpart of this
Agreement or a Unit purchase or issuance agreement by or on behalf of such
Person intending to be bound by the terms of this Agreement.  The parties hereto
agree that this Agreement, each Unit purchase or issuance agreement and any
additional information incidental thereto may be maintained as electronic
records.  Any Person providing an Electronic Signature further agrees to take
any and all additional actions, if any, evidencing their intent to be bound by
the terms of this Agreement, as may be reasonably requested by the Manager.

 

15.13      No State-law Partnership.  The Members intend that the LLC not be a
partnership (including a limited partnership) or joint venture, and that no
Member be a partner or joint venturer of any other Member by virtue of this
Agreement, for any purposes other than for U.S. federal income tax purposes as
set forth in Section 15.14, and neither this Agreement nor any other document
entered into by the LLC or any Member relating to the subject matter hereof
shall be construed to suggest otherwise.

 

15.14      Tax Classification.  It is the intent of the Members that, prior to
any conversion of the LLC to a corporate legal entity in compliance with the
provisions of this Agreement, the LLC shall always be operated in a manner
consistent with its treatment as a “partnership” for federal, state and local
income and franchise tax purposes at all times that it has two (2) or more
Members and as a disregarded entity for federal, state and local income and
franchise tax purposes at all times that it has one (1) Member.  In accordance
therewith, (a) no Member or Manager shall file any election with any taxing
authority to have the LLC treated otherwise, and (b) each Member and Manager
hereby represents, covenants, and warrants that it shall not maintain a position
inconsistent with such treatment.  The Members and Manager agree that at all
times that the LLC has two (2) or more Members, except as otherwise required by
applicable law, they (i) will not cause or permit the LLC to elect (A) to be
excluded from the provisions of Subchapter K of the Code, or (B) to be treated
as a corporation or an association taxable as a corporation for any tax
purposes; (ii) will cause the LLC to make any election reasonably determined by
the Tax Matters Member to be necessary or appropriate in order to ensure the
treatment of the LLC as a partnership for all tax purposes; (iii) will cause the
LLC to file any required tax returns in a manner consistent with its treatment
as a partnership for tax purposes; and (iv) have not taken, and will not take,
any action that would be inconsistent with the treatment of the LLC as a
partnership for such purposes.

 

52

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15.15      Severability.  If any provision of this Agreement is held to be
illegal, invalid, or unenforceable under any present or future laws applicable
to the LLC effective during the term of this Agreement, or in conflict with or
prohibited by Section 3.12: (i) such provision will be fully severable;
(ii) this Agreement will be construed and enforced as if such illegal, invalid,
unenforceable or conflicting provision had never comprised a part of this
Agreement and to give effect to Section 3.12 to the maximum extent possible to
reflect the intention of the parties; and (iii) the remaining provisions of this
Agreement will remain in full force and effect and will not be affected by the
illegal, invalid, unenforceable or conflicting provision or by its severance
from this Agreement.

 

15.16      No Third Party Beneficiary. This Agreement is made solely and
specifically among and for the benefit of the parties hereto and their
respective successors and permitted assigns, and no other Person will have any
rights, interest, or claims hereunder or be entitled to any benefits under or on
account of this Agreement as a third party beneficiary or otherwise. 
Notwithstanding the foregoing, any Person that is entitled to be indemnified by
the LLC pursuant to Section 13.1 shall be entitled to enforce its right to
indemnification therein.

 

15.17      Interpretation.  The titles and section headings set forth in this
Agreement are for convenience only and shall not be considered as part of
agreement of the parties.  When the context requires, the plural shall include
the singular and the singular the plural, and any gender shall include all other
genders.  The parties intend that no provision of this Agreement shall be
interpreted or construed against any party because such party or its counsel was
the drafter thereof.

 

15.18      Aggregation of Units.  All Units held or acquired by Affiliates of
Members shall be aggregated together for the purpose of determining the
availability of any rights under this Agreement.

 

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IN WITNESS WHEREOF, the parties have executed this Agreement on the day and year
first indicated above.

 

 

MEMBERS:

 

 

 

 

 

THERAVANCE, INC.

 

 

 

 

 

By:

/s/ Michael W. Aguiar

 

 

 

 

Name:

Michael W. Aguiar

 

 

 

 

Title:

Chief Financial Officer

 

 

 

 

 

 

 

THERAVANCE BIOPHARMA, INC.

 

 

 

 

 

 

 

By:

/s/ Rick E Winningham

 

 

 

 

Name:

Rick E Winningham

 

 

 

 

Title:

Chief Executive Officer

 

 

 

 

MANAGER:

 

 

 

 

 

 

 

THERAVANCE, INC.

 

 

 

 

 

 

 

By:

/s/ Michael W. Aguiar

 

 

 

 

Name:

Michael W. Aguiar

 

 

 

 

Title:

Chief Financial Officer

 

SIGNATURE PAGE TO THERAVANCE RESPIRATORY COMPANY, LLC

LIMITED LIABILITY COMPANY AGREEMENT

 

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LLC:

 

 

 

 

 

THERAVANCE RESPIRATORY COMPANY, LLC

 

 

 

By:

/s/ Rick E Winningham

 

 

 

 

Name:

Rick E Winningham

 

 

 

 

Title:

Chief Executive Officer and President

 

SIGNATURE PAGE TO THERAVANCE RESPIRATORY COMPANY, LLC

LIMITED LIABILITY COMPANY AGREEMENT

 

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EXHIBIT A

 

MEMBERS; UNITS

 

Class A Members

 

Number of Class A Units

 

 

 

 

 

Theravance, Inc.

 

750

 

901 Gateway Boulevard

 

 

 

South San Francisco, CA 94080

 

 

 

 

 

 

 

Total Class A Units

 

750

 

 

Class B Members(1)

 

Number of Class B Units(1)

 

 

 

 

 

Theravance Biopharma, Inc.

 

2,125

 

Ugland House, South Church Street

 

 

 

George Town

 

 

 

Grand Cayman, Cayman Islands

 

 

 

 

 

 

 

Total Class B Units

 

2,125

 

 

Class C Members(1)

 

Number of Class C Units(1)

 

 

 

 

 

Theravance, Inc.

 

750

 

901 Gateway Boulevard

 

 

 

South San Francisco, CA 94080

 

 

 

 

 

 

 

Theravance Biopharma, Inc.

 

6,375

 

Ugland House, South Church Street

 

 

 

George Town

 

 

 

Grand Cayman, Cayman Islands

 

 

 

 

 

 

 

Total Class C Units

 

7,125

 

 

 

 

 

TOTAL UNITS

 

10,000

 

 

--------------------------------------------------------------------------------

(1)  After giving effect to the Theravance Biopharma Transfer.

 

A-1

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EXHIBIT B

 

MANAGER; OFFICERS; TAX MATTERS MEMBER

 

Manager:

 

Theravance, Inc.

 

Officers:

 

Rick E Winningham, Chief Executive Officer and President

Michael W. Aguiar, Chief Financial Officer, Treasurer and Secretary

 

Tax Matters Member:

 

Theravance, Inc.

 

B-1

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EXHIBIT C

 

ASSIGNED RIGHTS AND BENEFITS AND ASSUMED LIABILITIES

 

The Assignment of rights and benefits of Theravance under the Collaboration
Agreement relating to Assigned Collaboration Products and the Assumption of
Liabilities of Theravance under the Collaboration Agreement relating to Assigned
Collaboration Products shall include, without limitation, the following rights,
benefits and Liabilities (capitalized terms not otherwise defined shall have the
meaning given them in the Collaboration Agreement):

 

1.                                      The obligation of the LLC pursuant to
Section 2.1 of the Collaboration Agreement to license to GSK any Theravance
Patents, Theravance Know-How and Theravance’s rights in the Joint Inventions to
the extent such any such assets are included in the Assigned Assets assigned to
the LLC pursuant to this Agreement.

 

2.                                      The right to grant the prior written
consent to any sublicense or subcontract relating to the development or
manufacture of any Assigned Collaboration Product pursuant to Section 2.2 of the
Collaboration Agreement, and to require GSK to secure all appropriate covenants,
obligations and rights from any such sublicensee or subcontractor relating to
such sublicense or subcontract.

 

3.                                     The right to enforce the obligations of
GSK with respect to trademark and housemarks under Section 2.3 of the
Collaboration Agreement to the extent such obligations relate to any Assigned
Collaboration Product and the obligation to perform the obligations of
Theravance under Section 2.3 of the Collaboration Agreement to the extent
relating to the Assigned Collaboration Products.  For the avoidance of doubt,
the LLC shall own all Theravance Inventions invented after the Contribution Date
that relate primarily to the Assigned Collaboration Products and shall have a
non-exclusive license to all Joint Inventions invented after the Contribution
Date to the extent useful in the development and commercialization of the
Assigned Collaboration Products.

 

4.                                      The right to enforce GSK’s obligations
to use Diligent Efforts, as modified pursuant to Section 3.1 of the
Collaboration Amendment Agreement (as defined in the Agreement), to the extent
relating to any Assigned Collaboration Product.

 

5.                                      The right to require GSK to bear costs
and expenses pursuant to Section 4.2.2 of the Collaboration Agreement to the
extent such costs and expenses relate to Assigned Collaboration Products.

 

6.                                      The right to receive update reports
pursuant to Section 4.2.3(c) of the Collaboration Agreement to the extent such
reports relate to Assigned Collaboration Products.

 

7.                                      The right to enforce GSK’s obligations
pursuant to Section 4.2.4 of the Collaboration Agreement to the extent relating
to the Development of Assigned Collaboration Products.

 

--------------------------------------------------------------------------------

 

8.                                      The right to enforce GSK’s obligations
pursuant to Section 4.5.2. of the Collaboration Agreement to the extent relating
to any GSK Discontinued Compound to the extent such compound is an Assigned
Collaboration Product.

 

9.                                      The right to receive a Theravance
Discontinued Compound that is reverted pursuant to Section 4.5.3 of the
Collaboration Agreement to the extent such compound is an Assigned Collaboration
Product, provided that the LLC shall comply with the obligations with respect to
such reverted compound set forth in such section.

 

10.                               The right to enforce GSK’s obligations
pursuant to, and the obligation to comply with Section 4.5.4 of the
Collaboration Agreement to the extent there is an Assigned Collaboration Product
being Developed under the Collaboration Agreement.

 

11.                               The right to require GSK to Commercialize
Assigned Collaboration Products pursuant to Article 5 of the Collaboration
Agreement, including the right to enforce GSK’s obligation to bears costs and
expenses pursuant to Section 5.3.1 of the Collaboration Agreement to the extent
related to Assigned Collaboration Products and to receive any reports relating
thereto pursuant to Article 5, as modified by the Collaboration Amendment
Agreement.

 

12.                               The obligation to comply with Section 5.3.3 of
the Collaboration Agreement to the extent it applies to Assigned Collaboration
Products.

 

13.                               The right to receive all milestone payments
payable by GSK pursuant to Section 6.2.2 of the Collaboration Agreement relating
to Assigned Collaboration Products.

 

14.                               The obligation to make all milestone payments
payable pursuant to Section 6.2.3 of the Collaboration Agreement relating to
Assigned Collaboration Products.

 

15.                               The right to receive and the obligation to
deliver notices of Development Milestones pursuant to Section 6.2.4 of the
Collaboration Agreement relating to Assigned Collaboration Products.

 

16.                               The right to receive all royalties payable by
GSK pursuant to Section 6.3 of the Collaboration Agreement relating to Assigned
Collaboration Products.

 

17.                               The right to enforce the obligations of GSK
pursuant to Section 6.4 through 6.10 of the Collaboration Agreement with respect
to royalties payable by GSK relating to Assigned Collaboration Products.

 

18.                               The right to enforce the obligations of GSK,
and the obligation to perform the obligations of Theravance, pursuant to
Article 7 of the Collaboration Agreement with respect to promotional materials
and samples relating to the Assigned Collaboration Products.

 

19.                               The right to enforce the obligations of GSK,
and the obligation to perform the obligations of Theravance, pursuant to
Article 8 of the Collaboration Agreement with respect to regulatory matters
relating to the Assigned Collaboration Products.

 

--------------------------------------------------------------------------------

 

20.                               The right to enforce the obligations of GSK
pursuant to Article 9 of the Collaboration Agreement with respect to orders,
supply and returns relating to the Assigned Collaboration Products.

 

21.                               The right to enforce the obligations of GSK
pursuant to Article 10 of the Collaboration Agreement to the extent applicable
to the Assigned Collaboration Products, and the obligation to comply with the
confidentiality and use restrictions applicable to Confidential Information in
Section 10.1 of the Collaboration Agreement (including Section 10.5 thereof) to
the extent relating to Confidential Information received by the LLC, subject to
the permitted disclosure and use restriction set forth in Section 10.2 of the
Collaboration Agreement.

 

22.                               The obligation to comply with the restrictions
on publications and public announcements in Sections 10.3 and 10.4 of the
Collaboration Agreement, respectively, to the extent relating to Confidential
Information received by the LLC.

 

23.                               The obligation to comply with Section 11.4 of
the Collaboration Agreement and the right to enforce the obligations of GSK
pursuant to Section 11.4 of the Collaboration Agreement, in each case  to the
extent applicable to the rights and obligations under the Collaboration
Agreement assigned to the LLC pursuant to Section 4.1(a)(ii) hereof.

 

24.                               The right to be indemnified by GSK pursuant to
Section 12.1 of the Collaboration Agreement, subject to the limitations and
conditions contained therein, relating to the rights and benefits assigned to it
pursuant to Section 4.1(a)(ii) hereof.

 

25.                               The obligation to indemnify GSK and others 
pursuant to Section 12.2 of the Collaboration Agreement, subject to the
limitations and conditions contained therein, for Losses relating to the
Liabilities assumed by the LLC pursuant to the first sentence of
Section 4.1(c)(ii) hereof.

 

26.                               The obligations pursuant to Section 13.1.1 of
the Collaboration Agreement to prosecute and maintain Theravance Patents and
related applications to the extent they primarily relate to the Assigned
Collaboration Products and the right to enforce GSK’s obligations to pay
out-of-pocket costs and expenses pursuant to such section.

 

27.                               The right to enforce the obligations of GSK,
and perform the obligations of Theravance, pursuant to Section 13.1.2 of the
Collaboration Agreement to prosecute and maintain Patents covering Joint
Inventions, to the extent primarily related to Assigned Collaboration Products.

 

28.                               The right to enforce the obligations of GSK
pursuant to Section 13.1.3 of the Collaboration Agreement to prosecute and
maintain GSK Patents and related applications to the extent  primarily related
to an Assigned Collaboration Product.

 

29.                               The right to (i) exercise the step-in rights
pursuant to Section 13.1.5 of the Collaboration Agreement, to the extent such
GSK Patents or claims primarily relate to an Assigned Collaboration Product, and
(ii) require GSK to perform, and the obligation to perform,

 

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the rights and obligations of the Parties set forth in Sections 13.1.6 and
13.1.7, to the extent they relate to the Assigned Collaboration Products.

 

30.                               The obligation to assist and cooperate, and
the right to require GSK to assist or cooperate, with respect to Patent
Infringement Claims pursuant to Section 13.2.1 of the Collaboration Agreement to
the extent such claims primarily relate to an Assigned Collaboration Product.

 

31.                               The rights to defend the infringement of a
Theravance Patents pursuant to Section 13.2.2 of the Collaboration Agreement to
the extent primarily related to an Assigned Collaboration Product.

 

32.                               The right to join GSK as a party-plaintiff in
an infringement action pursuant to Section 13.2.3 of the Collaboration Agreement
to the extent that such action primarily relates to an Assigned Collaboration
Product.

 

33.                               The right to receive, and the obligation to
give, a Hatch-Waxman Certification under Section 13.3 of the Collaboration
Agreement to the extent the GSK Patent or Theravance Patent which is the subject
of such notice primarily relates to an Assigned Collaboration Product.

 

34.                               The right to receive and the obligation to
give assistance pursuant to Section 13.4 of the Collaboration Agreement with
respect to a legal action covered by Article 13 of the Collaboration Agreement
to the extent such legal action primarily relates to an Assigned Collaboration
Product.

 

35.                               The right and obligation to give written
consent with respect to a suit pursuant to Section 13.5 of the Collaboration
Agreement to the extent such suit primarily relates to an Assigned Collaboration
Product.

 

36.                               The right to terminate the Collaboration
Agreement pursuant to Section 14.2 of the Collaboration Agreement if GSK
materially breaches or defaults in the performance of any obligations under the
Collaboration Agreement, subject to the cure rights specified therein, if such
breach or default relates to an Assigned Collaboration Product; provided that
such right may only be exercised with the consent of Theravance (so long as it
retains a portion of the Collaboration Agreement) and all assignees to which
portions of the Collaboration Agreement have been assigned; and provided,
further, that such condition on the right to terminate will not limit any other
available rights or remedies.

 

37.                               The right to dispute GSK’s termination of a
Terminated Development Collaboration Product pursuant to Section 14.3 of the
Collaboration Agreement, if such product is an Assigned Collaboration Product.

 

38.                               The right to dispute GSK’s termination of a
Terminated Commercialized Collaboration Product pursuant to Section 14.4 of the
Collaboration Agreement, if such product is an Assigned Collaboration Product.

 

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39.                               Upon termination of the Collaboration
Agreement to which Section 14.6.1(a) of the Collaboration Agreement applies, the
obligation to transfer data and materials related to specified Collaboration
Products to the extent such products are Assigned Collaboration Products.

 

40.                               Upon termination of the Collaboration
Agreement to which Section 14.6.1(b) of the Collaboration Agreement applies, the
right to receive (i) data and materials related to Theravance Compounds,
(ii) regulatory filings, (iii) access rights, and (iv) rights to bring an action
against GSK, in each case to the extent such compounds are Assigned
Collaboration Products.

 

41.                               Upon termination of the Collaboration
Agreement to which Section 14.6.2 of the Collaboration Agreement applies, if the
Collaboration Product terminated after initiation of the first Phase III Study
with respect to such product is an Assigned Collaboration Product, the rights
set forth in Sections 14.6.2(a) through (d) thereof, subject to
Section 14.6.2(e) thereof.

 

42.                               Upon termination of the Collaboration
Agreement to which Section 14.6.3 of the Collaboration Agreement applies, if the
Terminated Commercialized Collaboration Product is an Assigned Collaboration
Product, the rights set forth in Sections 14.6.3(a) through (d) and (f) thereof,
subject to Sections 14.6.3(e) thereof.

 

43.                               Upon termination of the Collaboration
Agreement to which Section 14.6.4 of the Collaboration Agreement applies, the
right receive the (i) materials, (ii) regulatory filings, (iii) license filings
and (iv) stock, as specified therein, and the right to limit further Development
work by GSK, as specified therein, in each case to the extent such rights relate
to an Assigned Collaboration Product.

 

44.                               The right to receive royalties payable by GSK
pursuant to Section 14.9, and the obligation to pay royalties to GSK after
termination of the Collaboration Agreement pursuant to Section 14.9 thereof to
the extent that the product giving rise to such payment obligation is developed
and commercialized by the LLC.

 

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