Exhibit 10.45

MANAGEMENT SERVICE CONTRACT

between

Rhein Biotech GmhH, Eichsfelder StraƒÀe 11, 40595 Düsseldorf, Germany,

- hereinafter referred to as "Company" -

and

Mr. Zbigniew Janowicz, Millrather Weg 74, D 40699 Erkrath

- hereinafter referred to as "Managing Director" -

Art. 1 - Scope of Duties

(1)      As of January 1, 2005 Mr Zbigniew Janowicz has been appointed as
Managing Director and COO of the company. By this contract, the parties enter
into a service relationship. In his capacity as Managing Director, he is
responsible for the management of the Company and – upon request of the
Supervisory Board – of subsidiaries and associated companies   (2)      The
Managing Director conducts the business of the Company in compliance with
applicable laws, the Articles of Association of the Company, the Rules of
Procedure for the Management Board, if any, and this Service Contract.   (3)   
  The Supervisory Board may at any time, appoint additional managing directors,
and/or assign different or additional to the Managing Director  

Art. 2 – Working Hours and Other Activities

The Managing Director shall devote the working hours (minimal 40 per week)
needed to execute the assigned work and tasks. If the course of the business
requires that the Managing Director works overtime, he shall be obliged to do
so.

Any other activity for remuneration and any activity, which normally entitles to
remuneration, including any part-time work, will have to be approved by the
Supervisory Board; which approval shall not be unreasonably withheld.

Art. 3 – Remuneration

(1)      The Managing Director shall be entitled to a fix gross annual salary in
the amount of €150.000, - to be paid in arrears in twelve equal monthly
installments.   (2)      In addition to the fixed salary payment pursuant to
subsec. (1) above, the Managing Director shall be entitled to a variable
remuneration pursuant to the bonus plan which shall be agreed separately
annually.   (3)      By payment of the salary under subsec. (1), all activities,
which the Managing Director has to perform under this Service Contract shall be
compensated. In particular, the Managing Director shall not be entitled to any
additional compensation for overtime work.  

Art. 4 – Reimbursement of Expenses and Additional Benefits

(1)      Upon presentation of proper receipts, the Managing Director shall be
reimbursed for reasonable and necessary expenses incurred in the interest of the
Company and within the framework of the principles applicable in Germany for tax
purposes.  

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(2)      The Company shall take out for the Managing Director an Officers and
Directors Liability Insurance with adequate coverage.   (3)      The Company
shall, at its expense – with a maximum of a monthly lease of EUR 750 excl VAT
provide the Managing Director a company car of a suitable type. All cost shall
be born by the Company. All tax effects resulting from the private use of the
company car by the Managing Director shall be born by the Managing Director.  

Art. 5 - Inventions

(1)      All rights pertaining to inventions, whether patentable or not, and to
proposals for technical or other improvements made or developed by the Managing
Director (hereinafter jointly referred to as “Inventions”) while fulfilling of
this Service Contract shall be deemed acquired by the Company without paying
extra compensation therefore. The Managing Director shall inform the Company or
a person designated by the Company in acquiring patents or other industrial
property rights, if the Company so desires.  

Art. 6 – Inability to perform duties and remuneration in case of disability

(1)      In case the Managing Director shall be unable to perform his duties
under this Service Contract, He shall inform the Company of such absence and its
prospective duration without undue delay. Upon request, he shall inform the
Company for the reasons of such absence.   (2)      In the event of incapacity
to perform his duties under this Service Contract due to illness or accident
without the Managing Director’s fault, he shall be entitled to a continuation if
his monthly gross base salary according to Art. 3 subsec. (1) of this Service
Contract for a maximum duration of 12 months, however not exceeding the date of
expiration or termination of this Service Contract. Any sick pay paid by a
public or private health insurance authority or carrier will be deducted from
the Company’s sick pay.  

Art.7 – Vacation

(1)      The Managing Director is entitled to 30 working days of vacation per
calendar year. Working days are all calendar days excluding Saturdays, Sundays
and bank holidays at the Company’s registered seat.   (2)      The time of
vacation has to be co-ordinated with the other members of the Management Board,
taking into consideration the Company’s business needs.  

Art. 8 – Secrecy and Return of Documents

(1)      The Managing Director shall, during the term of and also after the
termination of this Service Contract, keep confidential any information relating
to the Company’s business, its contractual relationships, its clients, its
organization, its sales and all other confidential matters of the Company or
affiliated companies, and he shall not use such information for his own benefit
or for the benefit of third parties.   (2)      When leaving the Company, the
Managing Director shall return to the Company all documents, letters, records,
drafts, calculations, personal notes, etc., including duplicates and copies
thereof, which relate to the business of the Company or affiliated Companies.
The Managing Director shall have no right of retention.  

Art. 9 – Term of Contract

(1) This Service Contract is entered into for an indefinite period.

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(2)      Both parties are entitled to terminate this Service Contract by giving
12 months’ prior notice effective to the end of any calendar month.   (3)     
In case this Service Contract has been terminated, the Company is entitled to
relieve the Managing Director from work at any time. In such case, the Company
shall continue to pay the salary to the Managing Director.  

Art. 10 - Final Provisions

(1)      This Service Contract contains the entire agreement between the
parties. Prior agreements concluded with the Company, affiliated companies or
subsidiaries are herewith expressly terminated.   (2)      Amendments of or
additions to this Service Contract, including this Sec. 11 subsec. (2), must be
made in writing in order to be effective.   (3)      This Contract is governed
by the laws of the Federal Republic of Germany.   (4)      Place of performance
is the place of business of the Company   (5)      In the event that a provision
of this Service Contract is or becomes wholly or partly invalid or
impracticable, the validity of the remaining provisions of this Service Contract
shall not be affected. The wholly or partly invalid or impracticable provision
shall be replaced by a provision which reaches the economic purpose intended by
the invalid provision in the best possible way. The same holds true in case of
gaps of this Service Contract.  

[place, date] : Amesterdam, January 17, 2005    [place, date]:    Düsseldorf,
January 12,2005                                         Dr. Daan Ellens         
 /s/. Zbigniew Janowicz 

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                                       Rhein Biotech GmbH           Mr. Zbigniew
Janowicz 

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           Managing Director & COO 

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