EXHIBIT 10.1

FIRST AMENDMENT TO

SECURITIES PURCHASE AGREEMENT

This First Amendment to Securities Purchase Agreement (this “Amendment”) is
dated as of July 20, 2018, by and among Delcath Systems, Inc., a Delaware
corporation (the “Company”), and the purchasers identified on the signature
pages hereto (each, a “Purchaser,” or in the aggregate, the “Purchasers”).

WHEREAS, a Securities Purchase Agreement (the “Agreement”) dated as of June 4,
2018, which is hereby incorporated by reference, was previously entered into by
and among the Company and the Purchaser, and the parties desire to amend the
Agreement as set forth herein.

NOW, THEREFORE, IN CONSIDERATION of the mutual covenants contained in this
Amendment, and for other good and valuable consideration, the receipt and
adequacy of which are hereby acknowledged, the Company and each Purchaser agree
that the Agreement is hereby amended as follows:

AMENDMENTS

1.1 In Section 4.16 of the Agreement, the words “the next” are deleted and
replaced by the word “a,” and at the end of the first sentence of such section
the following words are added: “, to be filed no later than five Trading Days
after the first registration statement filed by the Company after the date of
this Agreement is declared effective.”

[Signature Pages Follow]

 

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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly
executed by their respective authorized signatories as of the date first
indicated above.

 

DELCATH SYSTEMS, INC. By:     Name:   Jennifer K. Simpson Title:   President and
Chief Executive Officer

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK

SIGNATURE PAGE FOR PURCHASER FOLLOWS]

 

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[PURCHASER SIGNATURE PAGES TO DELCATH SYSTEMS, INC. FIRST

AMENDMEN TTO SECURITIES PURCHASE AGREEMENT]

IN WITNESS WHEREOF, the undersigned have caused this Amendment to be duly
executed by

their respective authorized signatories as of the date first indicated above.

 

Name of Purchaser:    

Signature of Authorized Signatory of Purchaser:         Name of Authorized
Signatory:         Title of Authorized Signatory:        

 

 

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