Exhibit 10.1

Execution Version

FIRST AMENDMENT

This FIRST AMENDMENT (this “Amendment”) dated as of November 12, 2015 is among
Baxalta Incorporated, a Delaware corporation (the “Borrower”), JPMorgan Chase
Bank, National Association, as administrative agent (in such capacity, the
“Administrative Agent”) and the undersigned financial institutions.

R E C I T A L S:

A. The Borrower, the Administrative Agent and various lenders are parties to a
Credit Agreement dated as of July 1, 2015 (the “Credit Agreement”; capitalized
terms used but not defined herein have the meanings set forth in the Credit
Agreement).

B. The Borrower, the Administrative Agent and the undersigned Banks have agreed
to amend the Credit Agreement as set forth below.

NOW, THEREFORE, the parties hereto agree as follows:

1. Amendment to Credit Agreement. Upon the effectiveness hereof pursuant to
Section 3 below, the definition of “Change of Control” in Section 1.01 of the
Credit Agreement is amended in its entirety to read as follows:

“Change of Control” means the acquisition of ownership, directly or indirectly,
beneficially or of record, by any Person or group (within the meaning of the
Exchange Act and the rules of the SEC thereunder as in effect on the date
hereof) of fifty percent (50%) or more of the aggregate ordinary voting power
represented by the issued and outstanding Equity Interests of the Borrower.

2. Representations and Warranties of the Borrower. The Borrower represents and
warrants that:

(a) the execution, delivery and performance by the Borrower of this Amendment
have been duly authorized by all necessary corporate action and this Amendment
is a legal, valid and binding obligation of the Borrower, enforceable against
the Borrower in accordance with its terms, except as the enforcement thereof may
be subject to the effect of any applicable bankruptcy, insolvency,
reorganization, moratorium or similar laws affecting creditors’ rights
generally; and

(b) no Event of Default or Unmatured Event of Default has occurred and is
continuing.

3. Effectiveness. This Amendment shall become effective on the date on which the
Administrative Agent has received counterparts hereof signed by the Borrower,
the Administrative Agent and the Majority Banks.

--------------------------------------------------------------------------------

4. Miscellaneous.

(a) Except as specifically amended hereby, the Credit Agreement, the Notes and
the other agreements, instruments and documents executed in connection therewith
(collectively, the “Loan Documents”) shall remain in full force and effect and
are hereby ratified and confirmed.

(b) The execution, delivery and effectiveness of this Amendment shall not
operate as a waiver of any right, power or remedy of the Administrative Agent or
any Bank under the Credit Agreement or any other Loan Document, or constitute a
waiver of any provision of the Credit Agreement or any other Loan Document. Upon
the effectiveness of this Amendment, each reference in the Credit Agreement to
“this Agreement”, “hereunder”, “hereof”, “herein” or words of similar import
shall mean and be a reference to the Credit Agreement as amended hereby.

(c) Section headings in this Amendment are included herein for convenience of
reference only and shall not constitute a part of this Amendment for any other
purposes.

(d) The provisions of Sections 11.08 (Governing Law) and 11.11 (Execution in
Counterparts) of the Credit Agreement are incorporated herein by reference as if
set forth herein, mutatis mutandis.

[Signature Pages Follow]

 

2

--------------------------------------------------------------------------------

IN WITNESS WHEREOF, the parties have executed this Amendment as of the date and
year first above written.

 

BAXALTA INCORPORATED By:  

/s/ Todd Young

Name:   Todd Young Title:   SVP and Treasurer

 

Signature page to Baxalta Incorporated First Amendment

--------------------------------------------------------------------------------

JPMorgan Chase Bank, National Association, as Administrative Agent and as a Bank
By  

/s/ Lisa A. Whatley

  Name:   Lisa A. Whatley   Title:   Managing Director

 

Signature page to Baxalta Incorporated First Amendment

--------------------------------------------------------------------------------

Bank of America, N.A. By  

/s/ Joseph L. Corah

  Name:   Joseph L. Corah   Title:   Director

 

Signature page to Baxalta Incorporated First Amendment

--------------------------------------------------------------------------------

CITIBANK, N.A. By  

/s/ Laura Fogarty

  Name:   Laura Fogarty   Title:   Vice President

 

Signature page to Baxalta Incorporated First Amendment

--------------------------------------------------------------------------------

DEUTSCHE BANK AG NEW YORK BRANCH By  

/s/ Ming K. Chu

  Name:   Ming K. Chu   Title:   Vice President By  

/s/ Virginia Cosenza

  Name:   Virginia Cosenza   Title:   Vice President

 

Signature page to Baxalta Incorporated First Amendment

--------------------------------------------------------------------------------

GOLDMAN SACHS BANK USA By  

/s/ Jerry Li

  Name:   Jerry Li   Title:   Authorized Signatory

 

Signature page to Baxalta Incorporated First Amendment

--------------------------------------------------------------------------------

UBS AG, Stamford Branch By  

/s/ Denise Bushee

  Name:   Denise Bushee   Title:   Associate Director By  

/s/ Craig Pearson

  Name:   Craig Pearson   Title:   Associate Director

 

Signature page to Baxalta Incorporated First Amendment

--------------------------------------------------------------------------------

CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH By  

/s/ Christopher Day

  Name:   Christopher Day   Title:   Authorized Signatory By  

/s/ Karim Rahimtoola

  Name:   Karim Rahimtoola   Title:   Authorized Signatory

 

Signature page to Baxalta Incorporated First Amendment

--------------------------------------------------------------------------------

HSBC Bank USA, N.A. By  

/s/ Andrew Bicker

  Name:   Andrew Bicker   Title:   Senior Vice President

 

Signature page to Baxalta Incorporated First Amendment

--------------------------------------------------------------------------------

MIZUHO BANK (USA) By  

/s/ Bertram H. Tang

  Name:   Bertram H. Tang   Title:   Senior Vice President

 

Signature page to Baxalta Incorporated First Amendment

--------------------------------------------------------------------------------

THE Bank of Tokyo-Mitsubishi UFJ, Ltd. By  

/s/ Jaime Johnson

  Name:   Jaime Johnson   Title:   VP

 

Signature page to Baxalta Incorporated First Amendment

--------------------------------------------------------------------------------

Bank of China, Chicago Branch By  

/s/ Xu Kefei

  Name:   Xu Kefei   Title:   SVP & Branch Manager

 

Signature page to Baxalta Incorporated First Amendment