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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 

EXECUTION VERSION

TERMINATION AND LICENSE AGREEMENT
 
This Termination and License Agreement (the “Agreement”) is made and entered
into effective as of November 4, 2009 (the “Effective Date”), by and between
Micromet AG, having its principal place of business at Staffelseestrasse 2,
81477, Munich, Germany (“Micromet”), and MedImmune, LLC, having its principal
place of business at One MedImmune Way, Gaithersburg, MD 20878
(“MedImmune”).  Micromet and MedImmune each may be referred to herein
individually as a “Party,” or collectively as the “Parties.”
 
RECITALS
 
WHEREAS the Parties have entered into a Collaboration and License Agreement (as
defined below);
 
WHEREAS the Parties desire to terminate the Collaboration and License Agreement;
 
WHEREAS pursuant to such termination, MedImmune is surrendering rights to the
Licensed Product (as defined in the Collaboration and License Agreement),
including the rights provided under Section 3.6.2 thereof; and
 
WHEREAS the Parties desire that the rights and obligations of the Parties with
respect to the Licensed Product (as defined below) be governed by this
Agreement.
 
In consideration of the foregoing premises and the mutual promises and covenants
contained herein and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the Parties hereby agree as
follows:
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
AGREEMENT
 
1.
Definitions

 
When used in this Agreement, capitalized terms will have the meanings as defined
below and throughout the Agreement.
 
1.1          “Affiliate” means a legal entity that, directly or indirectly,
through one or more intermediaries, controls, is controlled by, or is under
common control with a Party.  For purposes of this definition only, “control”
and, with correlative meanings, the terms “controlled by” and “under common
control with” means (a) the possession, directly or indirectly, of the power to
direct the management or policies of a legal entity, whether through the
ownership of voting securities or by contract relating to voting rights or
corporate governance, or (b) the ownership, directly or indirectly, of more than
50% of the voting securities or other ownership interest of a legal entity;
provided, however, that if local law restricts foreign ownership, control will
be established by direct or indirect ownership of the maximum ownership
percentage that may, under such local law, be owned by foreign interests.
 
1.2          “Applicable Law” means the laws, rules, and regulations, including
any statutes, rules, regulations, or other requirements, that may be in effect
from time to time and that apply to the development, manufacture, registration,
and marketing of Licensed Product in the United States and the European Union
and its member states, including any such statutes, rules, regulations, or other
requirements of the FDA and the EMEA.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
1.3          “BiTE Molecule” means a polypeptide comprising a bi-specific Single
Chain Antibody binding to T-cells.
 
1.4          “BiTE Product” means any compositions or formulation containing a
BiTE Molecule.
 
1.5          “BLA” means a Biologics License Application filed with the FDA in
conformance with applicable laws and regulations.
 
1.6          “cGMP” means current Good Manufacturing Practices as contained in
21 CFR Parts 210 and 211 as amended from time to time, and the equivalent
Applicable Laws in jurisdictions outside the United States.
 
1.7          “Clinical Materials” has the meaning set forth in Section 4.1.
 
1.8          “Collaboration and License Agreement” means the Collaboration and
License Agreement by and between MedImmune, LLC (formerly MedImmune, Inc.) and
Micromet AG, effective June 6, 2003 and any amendment thereto made prior to the
Effective Date.
 
1.9          “Collaboration Technology” means Joint Collaboration Technology or
MedImmune Collaboration Technology.
 
1.10        “Commercialization” means marketing, promotion, advertising, selling
or distribution of a Licensed Product.  The term Commercialize has a correlative
meaning.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
1.11        “Control” and, with correlative meaning, the term “Controlled,”
means, with respect to any Patent, Know-How, or other intellectual property
right of a Party, the ability to grant the other Party access, a license or a
sublicense (as applicable) or right to use such Patent, Know-How, or
intellectual property right as provided in this Agreement without violating the
terms of any agreement or other arrangement with any Third Party existing at the
time such Party would be required under this Agreement to grant the other Party
such access, license, sublicense or right of use.
 
1.12        “EMEA” means the European Medicines Agency and any successor agency
thereof.
 
1.13        “FDA” means the United States Food and Drug Administration and any
successor agency thereof.
 
1.14        “FTE” means the equivalent of a total of [***] hours per year of
scientific or technical work on or directly related to tasks to be performed
under this Agreement, carried out by a qualified employee of MedImmune.
 
1.15        “FTE Rate” means US $[***] per FTE per annum, which amount includes,
for each FTE, [***] and [***], [***], and a [***] plus [***].
 
1.16        “IND” means the Investigational New Drug Application #100135
(including all amendments and supplements thereto) as filed with the FDA and in
existence as of the Effective Date.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
1.17        “Independent MedImmune Technology” means any Patent or Know-How,
other than MedImmune Collaboration Technology, and other than MedImmune Process
Technology that (a) is owned by MedImmune as of the Effective Date, and (b) in
the case of Patents, claims or covers the composition, use, or manufacture of a
Licensed Product, in each case as the foregoing is used or exists as of the
Effective Date, or compounds or materials used or employed in the manufacture or
use thereof as of the Effective Date or, in the case of Know-How, is useful with
respect to any of the foregoing.  Independent MedImmune Technology does not
include Know-How with respect to the recipe of Media Materials.
 
1.18        “Joint Collaboration Technology” means any Patents and Know-How made
or generated jointly by employees, or Third Party agents or independent
contractors of both Parties or their Affiliates during the course of, in
furtherance of, and as a direct result of such employees, agents or independent
contractors performing an activity pursuant to the Collaboration and License
Agreement or this Agreement.
 
1.19        “Know-How” means (a) any scientific or technical information,
results and data of any type whatsoever, in any tangible or intangible form
whatsoever, including databases, practices, methods, techniques, specifications,
formulations, formulae, knowledge, know-how, skill, experience, test data
including pharmacological, medicinal chemistry, biological, chemical,
biochemical, toxicological and clinical test data, analytical and quality
control data, stability data, studies and procedures, and manufacturing process
and development information, results and data, and (b) any biological, chemical,
or physical materials.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
1.20        “Licensed Product” means MT103 alone or as part of a composition or
formulation.
 
1.21        “MAA” means a marketing approval application filed with the EMEA,
and any corresponding applications in countries or territories other than the
European Union and other than the United States.
 
1.22        “Manufacturing Process” means the [***] process used by MedImmune as
of the Effective Date to manufacture Clinical Materials and/or Licensed Product.
 
1.23        “Marketing Approval” means the approval of a BLA or MAA, and any
pricing and reimbursement approvals to the extent required by Applicable Law
prior to the marketing and sale of pharmaceutical products in a country.
 
1.24        “MedImmune Collaboration Technology” means (i) the Patents listed on
Exhibit A, and (ii) any Know-How, (other than MedImmune Process Technology or
Know-How directed to manufacturing of any product,) made or generated solely by
employees, or Third Party agents or independent contractors of MedImmune or its
Affiliates during the course of, in furtherance of, and as a direct result of
such employees, agents or independent contractors performing an activity
pursuant to the Collaboration and License Agreement, and (iii) any Patents and
Know-How made or generated solely by employees, or Third Party agents or
independent contractors of MedImmune or its Affiliates (to the extent MedImmune
has the ability to grant such rights) during the course of, in furtherance of,
and as a direct result of such employees, agents or independent contractors
performing Services or consulting services pursuant to Section 5.6 of this
Agreement.  MedImmune Collaboration Technology does not include Know-How with
respect to the recipe of Media Materials.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
1.25        "Media Materials" as the meaning set forth in Section 5.2(a).
 
1.26        “MedImmune Process Technology” means any Patents and Know-How that
(i) in the case of Know How that is Controlled by MedImmune as of the Effective
Date and in each case that has been used by MedImmune with respect to the
Manufacturing Process, and (ii) in the case of Patents, that are owned by
MedImmune as of the Effective Date and would be infringed by use of the
Manufacturing Process.  MedImmune Process Technology does not include Know-How
with respect to the recipe of Media Materials.
 
1.27        “MT103” means the BiTE Product containing the BiTE Molecule with the
amino acid sequence set forth in Exhibit B.  Such BiTE Molecule is currently
known as blinatumomab.
 
1.28        “Net Sales” means the gross amount invoiced to Third Parties or
received from Third Parties without prior invoice, in either case by Micromet,
its Affiliates, or any of their licensees for the sale of a Licensed Product,
less: (a) trade, quantity and cash discounts allowed; (b) commissions,
discounts, refunds, rebates (including federal, state or local government
rebates), chargebacks, retroactive price adjustments, all to the extent allowed;
(c) refunds or credits for actual returns of a Licensed Product; (d) any tax
imposed on the production, sale, delivery or use of a Licensed Product,
including sales, use, excise or value added taxes, other than income taxes; (e)
freight and insurance costs included in the gross amount invoiced; (f) a
reasonable allowance for distribution expenses; and (g) actual write-offs of
uncollectible accounts receivable.  Such amounts will be determined from the
books and records of Micromet or its Affiliate, or their licensee in accordance
with United States generally accepted accounting principles as applied by such
entity consistently across its products.  “Net Sales” excludes any amounts
invoiced or received in connection with any transfers of a Licensed Product
between Micromet and its Affiliates or their licensees who have the right to
Commercialize a Licensed Product.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
1.29        “North America” means the United States of America, Canada, and
Mexico, and any territories or possessions of the foregoing countries.
 
1.30        “Patents” means (a) all patents and patent applications in any
country or supranational jurisdiction, and (b) any provisionals, substitutions,
divisions, continuations, continuations in part, reissues, renewals,
registrations, confirmations, reexaminations, extensions, supplementary
protection certificates and the like, of any such patents or patent
applications.
 
1.31        “Related Agreements” means individually or collectively the
following agreements: [***] between MedImmune, LLC, MedImmune Pharma BV, and
Micromet AG of [***]; [***] between MedImmune Pharma BV, Micromet AG and Output
Pharma Services GmbH of [***]; and [***] between MedImmune, LLC and Micromet AG,
dated [***].
 
1.32        “Royalty Term” has the meaning set forth in Section 8.4.
 
1.33        "Services" has the meaning set forth in Section 3.1.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
1.34        “Single Chain Antibody” means a single chain polypeptide having a
binding affinity for a cell surface antigen, and comprising: (a) a [***], (b) a
[***], and (c) [***] into a single chain polypeptide.
 
1.35        “Technology Patent” means (i) a Patent owned by or licensed to
Micromet that contains a claim that covers the making, using, selling, offering
for sale or importing of a Licensed Product or (ii) a Patent that is included in
Independent MedImmune Technology or (iii) a Patent that is included in MedImmune
Process Technology or (iv) a Patent that is included in Collaboration
Technology.
 
1.36        “Territory” means the entire world.
 
1.37        “Third Party” means any entity other than Micromet, MedImmune or
their respective Affiliates.
 
1.38        “Valid Claim” means an issued claim of an issued patent that has not
(a) expired or been canceled, (b) been declared invalid by a decision of a court
or other appropriate body of competent jurisdiction that has not been appealed
or that is not appealable, (c) been admitted to be invalid or unenforceable
through reissue, disclaimer or otherwise, or (d) been abandoned or disclaimed.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
2.
Termination and Release

 
2.1          Termination. As of the Effective Date, Micromet and MedImmune
hereby terminate the Collaboration and License Agreement and the Related
Agreements  and the rights and licenses granted thereunder and any and all
rights and obligations thereunder, including those incurred prior to, as of or
subsequent to the Effective Date, and no rights or obligations of the
Collaboration and License Agreement and the Related Agreements will survive such
termination, notwithstanding anything therein to the contrary; provided,
however, that the Related Agreements will survive and apply with respect to the
supply of Clinical Materials by MedImmune in accordance with this
Agreement.  For the avoidance of doubt, this Section 2.1 supersedes Articles 12
and 16 of the Collaboration and License Agreement.
 
2.2          Release. (a) Micromet, on behalf of itself and its Affiliates,
hereby releases and discharges MedImmune and its respective subsidiaries,
divisions, parents, Affiliates, agents and each of its respective officers,
directors, employees, representatives and agents, and (b) MedImmune, on behalf
of itself and its Affiliates, hereby releases and discharges Micromet and its
subsidiaries, divisions, parents, Affiliates, agents and each of its respective
officers, directors, employees, representatives and agents, in each case ((a)
and (b)), from any and all actions, claims, counterclaims, defenses and damages
whatsoever, known or unknown, in law or equity, whether in tort or contract or
otherwise, which the releasing Party ever had, now has or hereafter will or may
have, that can be, could be or could have been asserted by Micromet or MedImmune
in any judicial or non-judicial proceeding which in each case arises out of or
relates to any right obligation, breach, action or inaction of Micromet or
MedImmune with respect to the Collaboration and License Agreement and the
Related Agreements.  For the avoidance of doubt, the release of this Section 2.2
is not applicable to actions, claims, counterclaims, defenses and damages that
arise out of this Agreement.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
2.3          Research Agreement. Notwithstanding termination of the
Collaboration and License Agreement and the rights and licenses granted to
MedImmune thereunder, the Parties acknowledge and agree that the BiTE Research
Collaboration Agreement by and between the Parties, effective as of June 6, 2003
(the “Research Agreement”), remains in full force and effect and that the
releases of Section 2.2 of this Agreement are not applicable to the rights and
obligations of the Parties under the Research Agreement.  The Parties further
acknowledge and agree that Know-How (as defined in this Agreement) of Micromet
with respect to the Licensed Product (as defined in this Agreement) that is
useful with respect to Collaboration Products (as defined in the Research
Agreement) is included in Independent Micromet Technology (as defined in the
Research Agreement).
 
3.
Work to be Performed By MedImmune

 
3.1          Services.  MedImmune will use commercially reasonable efforts to
perform the services set forth in Exhibit C (the “Services”) within the time
frames described therein.  Micromet acknowledges and agrees that the performance
of the Services may not result in a desired or stated result and MedImmune has
no liability to Micromet for failing to achieve a desired or stated result and
no obligation to repeat such Services for Micromet.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
3.2          Price. With respect to the Services, Micromet will pay to MedImmune
the FTE Rate for MedImmune employees performing such Services and the amount
paid by MedImmune to a Third Party in relation to such Services.  Such amount
will be due and payable by Micromet to MedImmune within [***] of invoice
therefor and such invoices will be submitted no more frequently than once per
month.  Each invoice will include a description of the number of FTE hours
charged for the performance of the Services and a description of the Services
performed during the billing period.  MedImmune will not be obligated to perform
Services and Micromet will not be obligated to pay for Services that exceed the
budget of Exhibit C unless Micromet agrees in writing to pay for such Services
in excess of such budget.
 
4.
Supply of Clinical Materials

 
4.1          Clinical Materials. To the extent not already delivered on or prior
to the Effective Date, MedImmune will deliver to Micromet the materials set
forth in Exhibit D (the “Clinical Materials”) to be paid for by Micromet at the
price set forth in Exhibit D (the “Price”).  Except as set forth in this Section
4.1, MedImmune will not be obligated to supply Micromet with any Licensed
Product, Clinical Materials or any products or materials used in or for the
production of Licensed Product except for MedImmune’s obligations with respect
to Media Materials under Section 5.2(b).
 
4.2          Packaging, Shipping and Delivery.  MedImmune will ship the Clinical
Materials [***] (Incoterms 2000) [***] facility by a common carrier designated
by Micromet.  Each shipment will be made under the terms and conditions set
forth in this Agreement.  Each shipment will include a certificate of analysis
and a certificate of compliance and will be released by MedImmune Pharma BV’s
qualified person for import, labeling and distribution to clinical trial sites.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
4.3          Risk of Loss.  Risk of loss of Clinical Materials will be
transferred to Micromet [***] and thereafter with respect to any loss thereof,
Micromet will be responsible for payment to MedImmune for such Clinical
Materials.
 
4.4          Invoice and Payment.  Within [***] of acceptance of a shipment of
Clinical Materials, Micromet will pay to MedImmune the Price for the Clinical
Materials as set forth in an invoice therefor.
 
4.5          Warranties.  MedImmune hereby warrants that any Clinical Materials
provided by MedImmune to Micromet under this Agreement, at the time of delivery:
(a) will conform to the specifications for such Clinical Materials set forth in
Exhibit D (the “Specifications”), and (b) will have been manufactured and
shipped to Micromet in accordance with cGMP and Applicable Laws (collectively,
the “Product Warranties”).
 
4.6          Acceptance of Clinical Materials.  Micromet will have [***] after
receipt of each shipment of Clinical Materials (such period, the “Acceptance
Period”) to review such shipment and test the Clinical Materials therein.  If
Micromet believes that the Clinical Materials do not comply with the Product
Warranties, then Micromet will deliver to MedImmune written notice of rejection
(the “Rejection Notice”) of such Clinical Materials, stating in reasonable
detail the basis for such assertion of non-compliance with the Product
Warranties.  Any Clinical Materials not rejected within such [***] period will
be deemed to be accepted by Micromet; provided, however, that Micromet
thereafter may send a Rejection Notice for Clinical Material promptly following
the discovery of any failure to comply with the Product Warranties if such
non-compliance was not reasonably discoverable within such [***] period (each
such non-compliance a “Latent Defect”).  If a Rejection Notice is received by
MedImmune during the Acceptance Period, or thereafter as permitted with respect
to Latent Defects, then MedImmune and Micromet will provide one another with all
related paperwork and records (including quality control tests) relating to the
production of the Clinical Materials in question or the Rejection Notice.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
4.7          Disputes Regarding Clinical Trial Materials.
 
(a)          MedImmune and Micromet will attempt to resolve any dispute
regarding the conformity of a shipment of Clinical Materials with the Product
Warranties.  If such dispute cannot be settled within [***] of the submission by
each Party of such related paperwork and records to the other Party, then such
dispute will be resolved as set forth in this Section 4.7.
 
(b)          If the Clinical Materials are alleged not to conform with the
Product Warranties set forth in Section 4.5(a), then Micromet will submit a
sample of the batch of the disputed shipment to an independent testing
laboratory of recognized repute [***] for analysis, under Quality Assurance
approved procedures, of the conformity of such shipment of Clinical Materials
with the applicable Specifications.  The costs associated with such analysis by
such independent testing laboratory will be paid by the Party whose assessment
of the conformity of the shipment of Clinical Materials with the Specifications
was mistaken.  The determination by the independent testing laboratory, will be
final and binding.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(c)          If the Clinical Materials are alleged not to conform with the
Product Warranties set forth in Section 4.5(b), then such dispute will be
submitted to an arbitrator located in the state where the Clinical Materials are
manufactured.  Such arbitrator will have adequate scientific background and
training and will be selected jointly by Micromet and MedImmune.  Such
arbitrator, in accordance with the commercial arbitration rules of the Judicial
Arbitration and Mediation Services (“JAMS”), will determine whether the Clinical
Materials were non-conforming with the Product Warranties set forth in Section
4.5(b), and such arbitrator’s findings, will be final and binding.  The costs
and expenses associated with the retention of such arbitrator will be paid by
the Party whose assessment of the conformity of the shipment of Clinical Trial
Materials with the Product Warranties was mistaken.
 
4.8            Remedies for Non-Conforming Clinical Materials.  In the event
that the Parties agree, or an independent testing laboratory or an arbitrator
determines, pursuant to Section 4.7, that all or a portion of a shipment of
Clinical Materials fails to conform to the Product Warranties, then, as the sole
and exclusive remedy for such failure, Micromet will not be obligated to make
any payment for such non-conforming Clinical Materials and MedImmune will
reimburse any payments for such materials previously received from Micromet.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
4.9            Audits and Inspections.
 
(a)          Micromet will have the right to inspect and audit (i) the
facilities of MedImmune and Third Parties in which cGMP production for Licensed
Product, Media Materials, and bag diluent was produced but only to the extent
that such facilities are in operation and (ii) the documentation generated in
connection with the manufacture and testing of Licensed Product, Media Materials
and bag diluent.  MedImmune will have the right to redact documents to the
extent they contain the recipe for Media Materials.  With respect to a Third
Party facility and documentation, subject to any confidentiality requirements of
the Third Party, MedImmune will use reasonable efforts to cause any such Third
Party to permit such inspection and audit (but excluding the recipe of any Media
Materials).  Such inspection and audit will take place during regular business
hours with at least [***] prior notice to MedImmune.  Micromet will discuss the
results of any inspection and audit with MedImmune.  Micromet’s right to inspect
and audit is [***].
 
(b)          MedImmune will permit a regulatory authority to inspect and audit
the (i) the facilities of MedImmune and Third Parties in which cGMP production
for Licensed Product, Media Materials, and bag diluent was produced but only to
the extent that such facilities are in operation and (ii) the documentation
generated in connection with the manufacture and testing of Licensed Product,
Media Materials and bag diluent.  Micromet will pay all of the cost and expense
thereof including but not limited to those [***].  A representative from
Micromet will have the right to be present [***] at any such inspections or
audits by a regulatory authority.  Such representative from Micromet will [***]
in the event a regulatory authority requests information that is not related to
the Manufacturing Process.  MedImmune will promptly provide Micromet with copies
of inspection requests from any regulatory authority.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
 
5.
Transfer of Manufacturing Process and Regulatory

 
5.1            Technology Transfer.
 
(a)          As promptly as possible but no later than [***], Micromet will
identify to MedImmune a contract manufacturing organization that will
manufacture Licensed Product for Micromet.  Subject to such contract
manufacturing organization executing an agreement pursuant to Section 5.4,
MedImmune will provide Micromet and such identified manufacturer (to the extent
not previously provided by MedImmune) with the Know-How in its possession as of
the Effective Date that is MedImmune Process Technology, which includes, but is
not limited to, and in each case that exists as of the Effective Date, technical
reports and materials for process development activities that are relevant to
and would be required for  Micromet or its contract manufacturing organization
to perform such Manufacturing Process (including but not limited to any master
cell banks, working cell banks, fermentation processes, recovery steps
established, process validation, product identity assays, in-process-control
assays, relevant standard operating procedures, as well as samples of the
working cell bank prepared at MedImmune, and technical methods for assays
required for the applicable process.  For clarity, all Know-How within MedImmune
Process Technology in tangible form (except for biological, chemical, or
physical materials) to be provided under this Section 5.1(a) are listed in
Exhibit E-3.  In addition, MedImmune will have the right to redact the documents
to the extent they contain information that is not related to Manufacturing
Process or information related to the recipe of Media Materials.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(b)          Promptly after the Effective Date, the MedImmune Project Manager,
his counterpart at Micromet, and other appropriate personnel of MedImmune and
Micromet will meet to establish a plan for the transfer of the Manufacturing
Process and the MedImmune Process Technology as is reasonable and customary in
the industry for the transfer of manufacturing processes and designed to
complete the transfer of the Manufacturing Process and the MedImmune Process
Technology within the timeframe set forth in subsection (c) below (the “Transfer
Plan”), which Transfer Plan will be deemed part of this Agreement and
incorporated herein by reference.  Within [***] from the date on which MedImmune
is informed of the contract manufacturing organization (“CMO”) selected by
Micromet for the manufacture of the Licensed Product, MedImmune will make
appropriate personnel available to meet with the CMO to initiate such process
transfer.
 
(c)          MedImmune will [***] to complete transfer of the Manufacturing
Process and the MedImmune Process Technology to such manufacturer within [***]
from that first meeting.  Such timelines will be extended for delays that are
reasonably outside the control of MedImmune, including but not limited to delays
related to the performance of Micromet, its contract manufacturer, or
licensees.  Upon completion of the transfer of the Manufacturing Process and the
MedImmune Process Technology, MedImmune will not have any further obligations to
provide additional MedImmune Process Technology to Micromet or its manufacturer.
 
(d)          MedImmune's obligation with respect to the Manufacturing Process
and the MedImmune Process Technology is limited to transfer of the Manufacturing
Process Technology in accordance with this Section 5.1 and providing consulting
services pursuant to Section 5.6 and MedImmune does not covenant, warrant or
represent that the Manufacturing Process and/or the MedImmune Process Technology
when used by or on behalf of Micromet or its sublicensees will be suitable for
producing Clinical Materials and/or Licensed Product.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
5.2            Supply of Cell Culture Media and Nutrient Feeds.
 
(a)          Promptly after the Effective Date, MedImmune [***] [***].
 
(b)          Promptly after the Effective Date, MedImmune will deliver to
Micromet or its designee the Media Materials listed in Exhibit H.  In addition,
in the event that (i) Micromet is [***] for a necessary component of the Media
Materials [***] within a period of [***] from the Effective Date after having
used reasonable efforts to do so, or (ii) if a [***] with Micromet (except in
the event of such [***] of this Agreement or its agreement with a Media
Supplier), or (iii) in the event such [***] to Micromet, then MedImmune will
provide Micromet (or Micromet’s contract manufacturer or licensee manufacturing
the Licensed Product) with Micromet’s (or such contract manufacturer’s or
licensee’s) [***] of the Media Materials necessary for the manufacture of the
Licensed Product [***] pursuant to a separate supply agreement to be executed
promptly after the Effective Date, which agreement will include the terms set
forth in this Section 5.2(b) (including terms for reasonable advanced forecasts
for Media Materials) and such other terms that are consistent with the terms
under which MedImmune purchases Media Materials from its third party supplier.
 
(c)          Micromet will not, and will cause its Affiliates, licensees and
their respective manufacturers not to (i) directly or indirectly, take any steps
to ascertain the recipe of any Media Materials provided by MedImmune and/or a
Media Supplier, and (ii) to not use the Media Materials for any purpose other
than manufacturing Licensed Product.  In the event Micromet, its Affiliates,
licensees, or their respective manufactures ascertains or receives the recipe of
any Media Material through no fault of its own, Micromet will and cause its
Affiliates, licensees, and their respective manufacturers to promptly inform
MedImmune of such event and destroy such information.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(d)          MedImmune will provide (at Micromet’s cost) to Micromet, or at the
discretion of MedImmune to the applicable regulatory agencies, all necessary CMC
documentation in its possession relating to Media Materials required for
regulatory filings for the Licensed Product.
 
(e)          MedImmune may elect to terminate supply of some or all of the Media
Materials by providing Micromet with the recipes therefor, in which case
MedImmune’s obligation to supply such component of the Media Materials will
expire, and Micromet will terminate any supply agreements with the applicable
Media Supplier(s) no later than [***] after MedImmune provides the recipes.
 
5.3            Cost of Transfer.  Except for the internal FTEs of MedImmune (not
to exceed [***] FTEs total), the cost of which will be borne by MedImmune,
Micromet will pay all of the cost and expense (including the cost and expense of
Third Parties) for transfer of the Manufacturing Process and the MedImmune
Process Technology to Micromet or any Third Party pursuant to this
Agreement.  In the event MedImmune’s internal costs exceed [***] FTEs, Micromet
will reimburse MedImmune for such costs above [***] FTES within [***] of invoice
therefor.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
5.4            Process Transfer.  Micromet will have the right to transfer the
Manufacturing Process and/or, the MedImmune Process Technology and/or Media
Materials to any Affiliate and to any Third Party (which may include a licensee
of Micromet) that is to manufacture Licensed Product for Micromet or its
licensees; provided, however, that prior to such transfer, such Third Party will
execute the agreement with MedImmune in the form attached hereto as Exhibit F
which will require it to comply with the restrictions of Section 5.2 as to Media
Materials and that contains confidentiality and non-use obligations
substantially similar to those set forth in this Agreement with respect to
Confidential Information of MedImmune.  Except as provided in this Section 5.4
and in Section 6.1(d), Micromet will not transfer Media Materials and/or
transfer Know-How that is MedImmune Process Technology or the Manufacturing
Process to any Third Party.  In the event that an agreement between Micromet and
a Third Party with respect to Licensed Product is terminated, Micromet will
notify MedImmune of such termination within [***] of such termination.
 
5.5            Non-Clinical, Clinical and Regulatory Documentation.  MedImmune
will transfer to Micromet the clinical and non-clinical information and
documentation listed in Exhibit E-1 within [***] from the Effective Date. The
Parties acknowledge that MedImmune has transferred to Micromet the clinical and
regulatory filings and documentation listed in Exhibit E-2, including the (i)
IND, (ii) all regulatory correspondence related to the IND, (iii) all orphan
drug designations and all amendments, and (iv) all regulatory correspondence
related to the orphan drug designations. The Parties acknowledge that MedImmune
has also transferred to Micromet the safety database relating to the Licensed
Product.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
5.6            Consulting Services.  From time to time, Micromet may submit to
MedImmune a written request to the designated MedImmune Project Manager as
defined in Section 5.7 to provide consulting services to Micromet with respect
to the Manufacturing Process, which request will include the specifics of the
consulting services being requested.  Micromet will provide at least [***]
advanced notice for all such requests to MedImmune.  In the event that [***],
then MedImmune will use reasonable efforts to promptly provide such consulting
services.  For the avoidance of doubt, MedImmune will not be required to provide
general process development consulting services that could be provided by any
contract manufacturing organization.  In no event will MedImmune be obligated to
provide more than [***] of consulting services in any [***], or more than [***]
of consulting services for any [***].  Micromet will pay for such consulting
services rendered at the FTE Rate, within [***] of invoice
therefor.  MedImmune’s obligation to provide these consulting services will
expire [***] after Micromet files the first MAA or the first BLA for the
Licensed Product, whichever is earlier.  For the avoidance of doubt such
consulting services will not require MedImmune to perform any of the following:
 
(a)          generate new scientific data or make any changes to the
Manufacturing Process;
 
(b)          write or create additional reports, manuscripts, or regulatory
documents;
 
(c)          have direct interaction or correspondence with any regulatory
agency except [***] or with respect to inspections by such regulatory agency as
provided in Section 4.9;
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(d)          disclose any Know-How that was not used by MedImmune in the
Manufacturing Process existing as of the Effective Date.
 
For the avoidance of doubt, MedImmune has no obligation to provide consulting
services to Micromet with respect to any subject matter other than the
Manufacturing Process.  Notwithstanding the preceding sentence, MedImmune as
part of the Consulting Services will use [***] to provide any raw data, report,
or other tangible Know-How within MedImmune Process Technology (in each case to
the extent such Know-How is in its possession and was not previously provided to
Micromet or its contract manufacturer) that is necessary to [***], subject to
the limitations of this Section 5.6.
 
5.7          Project Manager.      MedImmune will appoint a primary contact
person to represent MedImmune (“MedImmune Project Manager”) in its provision of
the services under this Agreement, including those in Articles 3, 4, and 5.  All
requests by Micromet regarding MedImmune’s services hereunder will be
coordinated through the MedImmune Project Manager, and Micromet will not
directly contact other employees of MedImmune unless previously authorized by
the MedImmune Project Manager.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
6.
License Grants

 
6.1             Licenses granted by MedImmune.
 
(a)          Subject to the terms and conditions set forth in this Agreement,
MedImmune hereby grants to Micromet an exclusive (even as to MedImmune),
royalty-bearing, right and license, with the right to grant and authorize the
grant of sublicenses, under the Independent MedImmune Technology and
Collaboration Technology, to make, have made, use, offer for sale, sell, and
import Licensed Products in the Territory.
 
(b)          Subject to the terms and conditions set forth in this Agreement,
MedImmune hereby grants to Micromet a co-exclusive (with MedImmune),
royalty-free right and license, with the right to grant and authorize the grant
of sublicenses, under the Collaboration Technology to make, have made, use,
offer for sale, sell, and import any BiTE Product (other than any BiTE Product
as to which MedImmune is exclusively licensed under the Research Agreement) in
the Territory.  The license set forth in this Section 6.1(b) is exclusive except
as to MedImmune and its licensees.  For the avoidance of doubt, the license
granted under this Section 6.1(b) does not include any MedImmune technology that
is not Collaboration Technology.
 
(c)          Subject to the terms and conditions set forth in this Agreement,
MedImmune hereby grants to Micromet an exclusive (even as to MedImmune),
royalty-bearing, right and license, with the right to grant sublicenses as
permitted by Section 6.1(d), under MedImmune Process Technology, to make and
have made Licensed Product for sale and use in the Territory.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(d)          Except to any licensee of rights to the Licensed Product or a
contract manufacturer for Micromet, its licensee or their respective Affiliates
pursuant to and in accordance with Section 5.4, Micromet will not sublicense,
transfer or disclose the Manufacturing Process or the MedImmune Process
Technology or provide the Media Materials to a Third Party without the prior
written consent of MedImmune and then only subject to such Third Party executing
the agreement with MedImmune in the form attached hereto as Exhibit F providing
for confidentiality and non-use provisions to protect the Confidential
Information of MedImmune and/or the Media Materials.
 
(e)          Other than the case where a sublicensee of Micromet has entered
into an agreement with MedImmune that indemnifies MedImmune in a manner
substantially identical to the indemnification of Section 14 of this Agreement
(including a CMO that has executed the confidentiality agreement in the form
attached as Exhibit F), any sublicense granted under this Section 6.1 will
require the sublicensee to indemnify MedImmune in accordance with Section 14 of
this Agreement, and Micromet will use reasonable efforts to have MedImmune
designated as third party beneficiary thereof with the right to enforce.  In the
event that MedImmune is not a third party beneficiary, Micromet agrees that
MedImmune will have the right to enforce such indemnity provisions in the name
of Micromet.
 
(f)          Any sublicense granted by Micromet will be made subject to and in
accordance with the terms of this Agreement.  If a sublicensee of Micromet
commits any act or omission relating to (i) MedImmune’s Confidential Information
disclosed by Micromet to such sublicensee, (ii) the practice of the sublicense
granted by Micromet under the licenses granted to it in this Agreement outside
the scope of the license granted to Micromet, (iii) the use or disclosure of
MedImmune’s confidential Know-How or (iv) Media Materials, in each case which
act or omission, if committed by Micromet, would constitute a material breach of
this Agreement, then Micromet will, upon request of MedImmune, terminate the
sublicense agreement with such sublicensee if such material breach is not cured
within [***] from notice thereof.  Promptly upon execution of each agreement
under which Micromet grants a sublicense under the licenses granted by MedImmune
to Micromet under this Agreement, Micromet will provide to MedImmune a copy of
such sublicense agreement with financial provisions and scientific, technical
and other proprietary business information redacted.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(g)          Micromet hereby covenants and agrees not to grant any Third Party
any license or right under Independent MedImmune Technology or MedImmune Process
Technology, or Media Materials to develop or Commercialize any product other
than Licensed Product in the Territory and not to use or practice Independent
MedImmune Technology or MedImmune Process Technology except as expressly
permitted by this Agreement.  For the avoidance of doubt, nothing in this
Agreement will limit Micromet’s rights to use or grant Third Parties the right
to use information or Know-How Controlled by Micromet that was originally
transferred by Micromet to MedImmune under the Collaboration and License
Agreement, or to use information or Know-How Controlled by Micromet that was
used or developed by or on behalf of Micromet independent of or prior to the
transfer of MedImmune Process Technology to Micromet under this Agreement or the
Collaboration and License Agreement.
 
(h)          Micromet hereby covenants and agrees not to grant any Third Party
any license or right under MedImmune Collaboration Technology, or Media
Materials to develop or Commercialize any product other than BiTE Products in
the Territory and not to use or practice MedImmune Collaboration Technology
except as expressly permitted by this Agreement.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(i)          MedImmune hereby covenants and agrees that it will not license,
assign or otherwise transfer to any Third Party any of its right and interest in
and to any Patent that is Joint Collaboration Technology or MedImmune
Collaboration Technology or Media Materials for research, development,
manufacture, use or Commercialization of any BiTE Product, except in connection
with co-developing a BiTE Product(s) with such Third Party.  This limitation is
not applicable to any BiTE Product as to which MedImmune holds a license under
any other agreement with Micromet or its Affiliates.
 
6.2            Bankruptcy Provision under US Law. All rights and licenses
granted under or pursuant to this Agreement, including amendments hereto, by
MedImmune to Micromet are, for all purposes of Section 365(n) of Title 11 of the
U.S. Code (“Title 11”), licenses of rights to intellectual property as defined
in Title 11.  All rights, powers and remedies of Micromet provided in this
Section 6.2 are in addition to and not in substitution for any and all other
rights, powers and remedies now or hereafter existing at law or in equity
(including Title 11) in the event of the commencement of a Title 11 case by or
against MedImmune.  In such event, Micromet will be entitled to exercise all
other such rights and powers and resort to all other such remedies as may now or
hereafter exist at law or in equity (including under Title 11).
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
7.
Prosecution, Enforcement and Defense of Patents

 
7.1             Prosecution and Maintenance of Patents.
 
(a)          MedImmune will have the sole right to file, prosecute and maintain
Patents that are Independent MedImmune Technology or MedImmune Process
Technology and/or MedImmune Collaboration Technology.
 
(b)          With respect to Patents in the Collaboration Technology, MedImmune
will provide to Micromet all documents that relate to patent filing, prosecution
and maintenance, including each patent application, office action, response to
office action, request for terminal disclaimer, request for reissue or
reexamination and opposition or appeal proceedings or extension of any patent
issuing from such application sufficiently prior to the filing of such
application, response or request to allow for review and comment by
Micromet.  MedImmune agrees to consider in good faith and to take into account
all comments received from Micromet.
 
(c)          If MedImmune decides to discontinue the prosecution of a Patent or
abandon an issued Patent within Collaboration Technology, it will inform
Micromet thereof not less than [***] in advance of the deadline at which an
action is required to be taken in order to continue such prosecution of, or to
maintain such Patent, and upon request of Micromet, will allow Micromet to
continue the prosecution or maintenance of such Patent on behalf of MedImmune at
Micromet’s cost.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
7.2             Enforcement of Patents.
 
(a)          Within the Territory, with respect to the alleged infringement by a
Third Party of a Patent that is MedImmune Collaboration Technology or MedImmune
Process Technology or Independent MedImmune Technology licensed to Micromet
under this Agreement (a “Product Patent”) by making, using, selling, importing
or offering for sale a Licensed Product (a “Product Infringement”), with the
prior written consent of MedImmune, which consent may be granted or withheld in
the sole discretion of MedImmune, Micromet will have the right (but not the
obligation) to bring an infringement action or proceeding with respect to a
Product Infringement at the cost and expense of Micromet, by counsel of its own
choice.  MedImmune will have the right, at its own cost and expense, to be
represented in any such action by counsel of its own choice.  If Micromet fails
to bring such an action in the Territory within [***] of written notice thereof
from MedImmune to Micromet, then MedImmune will have the right to bring such
action at the cost and expense of MedImmune with counsel selected by
MedImmune.  Micromet, at its cost and expense, will have the right to be
represented by counsel in any such action brought by MedImmune.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(b)          If one Party brings any enforcement action or proceeding under this
Section 7 with respect to a Product Infringement, the other Party agrees to be
joined as party plaintiff if necessary to prosecute the action or proceeding and
to give the first Party reasonable assistance and authority to file and
prosecute the suit; provided, however, that neither Party will be required to
transfer any right, title or interest in or to any property to the other Party
or any other party to confer standing on a Party hereunder.  The Party bringing
the action will have the right to control such action, including the settlement
thereof, provided, however, that no settlement will be made that adversely
affects the validity, enforceability or scope of a Patent within MedImmune
Collaboration Technology or MedImmune Process Technology or Independent
MedImmune Technology unless agreed to in writing by both Parties, such agreement
not to be unreasonably withheld, delayed or conditioned.  Any damages or other
monetary awards recovered pursuant to any suit, proceeding or other legal action
taken under this Section 7.2 will be allocated first to the costs and expenses
of the Party bringing suit, and second to the costs and expenses (if any) of the
other Party that were authorized by the Party bringing the suit, with any
remaining amounts (if any) to be allocated to the Party bringing suit and if the
amount is allocated to Micromet, such amount will be Net Sales subject to
royalty under this Agreement.
 
8.
Fees and Payments

 
8.1             Upfront Fee.
 
(a)             Micromet will pay to MedImmune Six Million Five Hundred Thousand
Dollars ($6,500,000) which is non-refundable and non-creditable in the following
installments:
 
(i)         [***] payable on [***];
 
(ii)         [***] [***] payable on [***]; and
 
(b)             Intentionally left blank.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(c)          As to the installment due on [***], such payment is solely
contingent upon Micromet or its CMO having received the materials and reports of
Exhibit E-3 prior to such time.  For the avoidance of doubt, if MedImmune
delivers the materials and reports of Exhibit E-3 after [***], then such payment
will be due and payable upon such delivery.
 
8.2             Development Milestones.  Micromet will make the following
non-refundable, non-creditable payments to MedImmune in the amounts set forth
below within [***] of the occurrence of each of the following events with
respect to the first Licensed Product to achieve the applicable event:
 
Milestone Event
 
Milestone Payment
     
[***]
 
[***]
     
[***]
 
[***]
     
[***]
  
[***]

 
In the event that Milestone Event 2 occurs, and the payment for Milestone Event
1 has not been paid, then the milestone payment for Milestone Event 1 will be
made with the payment for Milestone Event 2.  The aggregate of Milestone
Payments payable by Micromet under this Section 8.2 will not exceed [***].
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
8.3             Royalties.
 
(a)          Subject to the adjustments provided for in Section 8.5, Micromet
will pay to MedImmune a royalty equal to [***] of Net Sales of Licensed Product
in North America.  For the avoidance of doubt, a sale that occurs outside of
North America for Licensed Product that is shipped for use in North America is
included in Net Sales in North America.
 
(b)          In the event that a Licensed Product is sold in combination with a
therapeutically active component that is not a Licensed Product (“Combination
Product”), then net sales (calculated as Net Sales) of such Combination Product
upon which a royalty is paid will be subject to the following adjustment.  If
the Licensed Product and the other therapeutically active component of the
Combination Product are sold separately in a country, then net sales of such
Combination Product in such country upon which a royalty is paid will be
multiplied by the fraction A/A+B, where A equals the average sales price of such
Licensed Product sold separately in such country, and B equals the average sales
price of the other therapeutically active component sold separately in such
country.  Otherwise, the Parties will enter into good faith negotiations and
attempt to reach mutual agreement to determine an appropriate adjustment to the
net sales of such Combination Product in a country to reflect the relative
contributions of the Licensed Product and the other therapeutically active
component to the value of the Combination Product in such country.  If such
mutual agreement is not reached within [***] after commencement of such
negotiations, then the determination will be submitted to binding arbitration
under Section 17.4(c).
 
(c)          Only one royalty will be due and payable for the manufacture, use
and sale of Licensed Product irrespective of the number of Valid Claims within
Technology Patents that cover the manufacture, use and sale of Licensed
Product.  Upon payment of a royalty under this Agreement with respect to a unit
of Licensed Product, no further royalty will be due with respect to such unit of
Licensed Product.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
8.4          Royalty Term.  On a country-by-country basis, royalties due under
Section 8.3 for Licensed Product will begin on the first sale of Licensed
Product following Marketing Approval in a particular country in North America
and continue on a country-by-country basis until the later of: (i) [***], or
(ii) [***] years from the first commercial sale following Marketing Approval of
such Licensed Product in such country in North America (the “Royalty Term”).
 
8.5          Royalty Adjustments.  In the event that one or more Third Parties
sell a Licensed Product in a country of North America and such sale (a) [***] or
(b) [***] hereunder with respect to which MedImmune declined Micromet’s request
to permit Micromet’s enforcement of [***] against such Third Party infringer,
and Micromet can demonstrate that the revenues from sales of such Licensed
Product by such Third Parties in such country in such calendar year amounts to
greater than [***] of the revenues from sales of Licensed Product by Micromet or
its licensees in such country in such calendar year, then the royalty payable by
Micromet pursuant to Section 8.3 on Licensed Product in such country for such
calendar year will be reduced to [***].  If sales by such Third Parties are only
for a portion of a calendar year, the greater than [***] of revenues from sales
will be determined over such portion of the calendar year.  Sales are to be
calculated in the currency of the applicable country and the reduction, if any,
is determined on a calendar year by calendar year basis such that the reduction
is applicable in a calendar year in a country only if Micromet demonstrates for
such calendar year in such country that the Third Party revenues from sales of
Licensed Product exceeds [***] of the revenues from sales of Licensed Product by
Micromet or its licensees in such country.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
8.6          Payment by MedImmune.  Within [***] after the Effective Date,
MedImmune will pay to Micromet [***], which amount is non-refundable and
non-creditable, and consists of [***] payable on account of past due amounts for
costs and expenses incurred by Micromet through [***] with respect to the
clinical study [***], and [***] payable on account of past due amounts for costs
and expenses incurred by Micromet through [***] with respect to the clinical
study [***].
 
9.
Payment Terms

 
9.1          Payment Method. All amounts due to a Party will be paid in United
States Dollars by wire transfer in immediately available funds to an account
designated by such Party.  The conversion for royalties will be made at the
exchange rate reported in the Wall Street Journal, Eastern Edition on the last
business day of the calendar quarter for which royalties are payable, and in all
other cases at such exchange rate on the date that the payment is due.  Any
payments or portions thereof due hereunder which are not paid on the date such
payments are due under this Agreement will bear interest at the lower of (i)
[***] over the overnight LIBOR rate in effect on the due date, or (ii) the
maximum rate permitted by law, calculated on the number of days such payment is
delinquent, compounded monthly.
 
9.2          Payment Schedules; Reports. Royalty payments due pursuant to
Section 8.3 are due and payable within [***] of the end of each calendar quarter
during the Royalty Term during which there were Net Sales of the applicable
product in North America.  Micromet will accompany each payment of royalties
under this Agreement with a report containing a detailed account of Net Sales of
each product for which royalties are due during the preceding calendar quarter.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
9.3             Records Retention; Audit.
 
(a)          Micromet will maintain complete and accurate books, records and
accounts used for the determination of royalties payable in connection with Net
Sales, in sufficient detail to confirm the accuracy of any payments required
under this Agreement, which books, records and accounts will be retained by
Micromet until [***] after the end of the period to which such books, records
and accounts pertain.
 
(b)          MedImmune will have the right to have an independent certified
public accounting firm of internationally recognized standing, reasonably
acceptable to have access during normal business hours, and upon reasonable
prior written notice, to such of the records of Micromet as may be reasonably
necessary to verify the accuracy of any payments received from Micromet for any
calendar quarter ending not more than [***] prior to the date of such request;
provided, however, that MedImmune will not have the right to conduct more than
one such audit in any [***] period.  The accounting firm will disclose to the
Parties only whether the Net Sales reported by the audited Party are correct or
incorrect and the specific details concerning any discrepancies.  The auditing
Party will bear all costs of such audit, unless the audit reveals a discrepancy
in the audited Party’s favor of more than [***], in which case the audited Party
will bear the cost of the audit.  The results of such accounting firm will be
final, absent manifest error.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(c)          If, based on the results of any audit, additional payments are owed
to a Party under this Agreement, the amount of such payments will be credited
against future amounts payable by such Party to the other Party under this
Agreement; provided, however, that if such additional payments are not fully
credited within [***] after the receipt of the applicable audit results, the
Party owing such additional payments will at such time pay the other Party any
uncredited amounts thereof.
 
(d)          Each party will treat all information subject to review under this
Section 9 in accordance with the provisions of Section 10 and will cause its
accounting firm to enter into a reasonably acceptable confidentiality agreement
with the audited Party obligating such firm to maintain all such financial
information in confidence pursuant to such confidentiality agreement.
 
10.
Confidentiality

 
10.1           Definition.  “Confidential Information” means (a) any Know-How,
and (b) any scientific, manufacturing, marketing and business plans, and
financial and personnel matters relating to a Party or its present or future
products, sales, suppliers, customers, employees, investors or business; in
either case, that has been disclosed by or on behalf of such Party to the other
Party either in connection with the discussions and negotiations pertaining to
this Agreement or in the course of performing this Agreement (including any
information disclosed under the Confidentiality Agreement between the Parties
dated [***]) and any information disclosed under the Collaboration and License
Agreement).
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
10.2           Exclusions.  Notwithstanding the foregoing, any information of a
Party will not be deemed Confidential Information with respect to a receiving
Party for purposes of this Agreement if such information:
 
(a)          was already known or available to the receiving Party or its
Affiliates, other than under an obligation of confidentiality or non-use to the
other Party, at the time of disclosure to the receiving Party;
 
(b)          was generally available or known to parties reasonably skilled in
the field to which such information pertains, or was otherwise part of the
public domain, at the time of its disclosure to the receiving Party;
 
(c)          became generally available or known to parties reasonably skilled
in the field to which such information pertains, or otherwise became part of the
public domain, after its disclosure to the receiving Party through no fault of
or breach of its obligations under this Section 10 by the receiving Party;
 
(d)          was disclosed to the receiving Party, other than under an
obligation of confidentiality or non-use, by a Third Party who had no obligation
to the Party that Controls such information not to disclose such information to
others; or
 
(e)          was independently discovered or developed by the receiving Party or
its Affiliates, as evidenced by their written records, without the use of, and
by personnel who had no access to, Confidential Information belonging to the
Party that Controls such information.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
10.3           Disclosure and Use Restriction.  Except as expressly provided
herein, the Parties agree that, during the Term and for [***] thereafter, each
Party and its Affiliates and sublicensees will keep completely confidential and
will not publish or otherwise disclose any Confidential Information of the other
Party, its Affiliates or sublicensees.  Neither Party will use any Confidential
Information of the other Party without such other Party’s consent, except as
expressly permitted by this Agreement.  Notwithstanding the foregoing, in the
event that MedImmune discloses the recipe of the Media Materials to Micromet,
the confidentiality obligations with respect thereto will remain in full force
and effect during the Term and without limitation thereafter.
 
10.4           Authorized Disclosure. Each Party may use and disclose
Confidential Information of the other Party to the extent that such use and
disclosure is:
 
(a)          made in response to a valid order of a court of competent
jurisdiction or other governmental or regulatory body of competent jurisdiction;
provided, however, that such Party will first have given notice to such other
Party and given such other Party a reasonable opportunity to quash such order
and to obtain a protective order requiring that the Confidential Information and
documents that are the subject of such order be held in confidence by such court
or governmental or regulatory body or, if disclosed, be used only for the
purposes for which the order was issued; and provided, further, that if a
disclosure order is not quashed or a protective order is not obtained, the
Confidential Information disclosed in response to such court or governmental
order will be limited to that information which is legally required to be
disclosed in response to such court or governmental order;
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(b)          otherwise required by law, rule, or regulation; provided, however,
that the disclosing Party will provide such other Party with notice of such
disclosure in advance thereof to the extent practicable;
 
(c)          made by such Party to the regulatory authorities as required in
connection with any filing of MAAs, Investigational New Drug Applications, BLAs,
marketing approval applications, or similar applications or requests for
regulatory approvals; provided, however, that reasonable measures will be taken
to assure confidential treatment of such information;
 
(d)          made by such Party, in connection with the performance of this
Agreement, to Affiliates, permitted sublicensees, research parties, employees,
consultants, representatives or agents, each of whom prior to disclosure must be
bound by obligations of confidentiality and non-use at least equivalent in scope
to those set forth in this Section 10;
 
(e)          made by such Party to existing or potential acquirers or merger
candidates; existing or potential pharmaceutical collaborators (to the extent
contemplated under this Agreement); investment bankers; existing or potential
investors, venture capital firms or other financial institutions or investors
for purposes of obtaining financing; or Affiliates, each of whom prior to
disclosure must be bound by obligations of confidentiality and non-use at least
equivalent in scope to those set forth in this Section 10; or
 
(f)          other than Media Materials made in a patent application filed in
conformance with this Agreement.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
10.5           Terms of Agreement to be Maintained in Confidence.  Subject to
the provisions of this Section 10, the Parties agree that the terms of this
Agreement are deemed Confidential Information of both Parties and will be
subject to the restrictions on use and disclosure set forth herein.
 
11.
Public Communications

 
11.1           Use of Name.  Neither Party will make public use of the other
Party’s name except (a) in connection with announcements and other permitted
disclosures relating to this Agreement and the activities contemplated hereby,
(b) as required by applicable law, rule, or regulation, and (c) otherwise as
agreed in writing by such other Party.
 
11.2           Press Releases.
 
(a)          Micromet will have the right to issue the press release attached
hereto as Exhibit G in connection with the execution of this Agreement.  Except
with respect to the terms of this Agreement that may be required to be disclosed
under Section 10.4(b), neither Party will make any public announcement regarding
the terms or the performance of this Agreement without the prior written
approval of the other Party.  Any press release containing information to be
disclosed under the terms of Section 10.4(b) will be made only in accordance
with the terms thereof.
 
(b)          A Party may publicly disclose without regard to the preceding
requirements of this Section 11.2 information that was previously disclosed in
compliance with such requirements.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
11.3         Publications.  MedImmune will not make any publications or
presentation of any material related to the research or development activities
performed by or on behalf of MedImmune under the Collaboration and License
Agreement or this Agreement except with prior written consent of
Micromet.  Micromet will not make any publications or presentations of any
material related to the research or development activities performed by or on
behalf of MedImmune under the Collaboration and License Agreement or this
Agreement that identifies MedImmune as the originator of the material, except
with the prior written consent of MedImmune.
 
12.
Term and Termination

 
12.1         Term.  The term of this Agreement (the “Term”) will commence on the
Effective Date and will expire upon the earlier of (i) [***] or (ii) [***] years
from the Effective Date, unless earlier terminated as provided in this
Agreement.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
12.2           Breach by Micromet.
 
(a)          In the event that Micromet materially breaches a payment obligation
under this Agreement, in addition to any other remedy (but subject to Section
12.4), including the right to bring an action to collect such payment, by [***]
prior written notice to Micromet, MedImmune will have the right to terminate
performance of its obligations under one or more of  Sections 3, 4 or 5, and if
the payment breach is under Section 8.1 or 8.2, MedImmune will also have the
right to send written notice to Micromet that the provisions of Section 12.2(c)
will come into effect unless such payment breach under Section 8.1 or 8.2 is
cured within [***].  If such payment breach is not cured within the [***]
period, the termination of performance pursuant to notice and/or the provisions
of Section 12.2(c), as the case may be, will automatically become effective.  In
the event that Micromet disputes a payment obligation for which MedImmune
provides notice under this Section and Micromet notifies MedImmune of such
dispute and makes the payment under protest within the applicable [***] period,
then (i) termination of performance pursuant to such notice and/or the
provisions of Section 12.2(c) will not become effective, and (ii)
notwithstanding such payment, Micromet will have the right to arbitrate under
Section 17.4 whether or not Micromet is obligated to make such payment and to
the extent Micromet prevails in such arbitration, MedImmune will return such
disputed payments to Micromet with interest calculated in accordance with
Section 9.1.
 
(b)          In the event that Micromet breaches Micromet’s obligations under
Sections 5.2 or 5.4 of this Agreement or Micromet’s obligations with respect to
Media Materials, MedImmune will have the right to send written notice to
Micromet of such breach.  In the event that such breach is not cured within
[***] or is not capable of cure, MedImmune will have the right to terminate
MedImmune’s obligations under Section 5.2 by written notice to Micromet and
Micromet will terminate all supply agreements for Media Materials. In the event
that Micromet disputes MedImmune’s claim that Micromet has breached its
obligations under Sections 5.2 or 5.4, Micromet will have the right to arbitrate
under Section 17.4 whether or not Micromet has breached such obligations, and
MedImmune will not have the right to terminate MedImmune’s obligations under
Section 5.2 until such breach has been found to exist in the final judgment made
by the arbitrator(s) in such arbitration.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(c)          [***]
 
12.3           Breach by MedImmune.  In the event that MedImmune commits a
material breach of its obligations under one or more of Sections [***] of this
Agreement, in addition to any other remedy (but subject to Section 12.4),
Micromet, will have the right prior to [***] to provide MedImmune with written
notice of such breach and the details thereof, and if such breach is not cured
within [***] of such written notice, upon written notice to MedImmune, Micromet
will have the right to either:
 
(a)          terminate this Agreement in the entirety.  In addition, Micromet
will have the right to pursue a claim for damages under Section 17.4 available
to it under law, subject to the limitations of [***] but not the limitations of
[***]; or
 
(b)          elect to keep this Agreement in full force and effect and initiate
a proceeding under Section 17.4 to determine whether MedImmune has committed a
material breach of its obligations under one or more of Sections [***] of this
Agreement.  Following a final determination under Section 17.4 that MedImmune
did commit such material breach that has not been cured, if in the arbitration
it is determined that such breach is not curable or if it is determined in the
arbitration that such breach is curable and MedImmune does not cure such breach
within [***] after such determination, then (i) the amount of future payments
due to MedImmune under Section 8.2 will be [***] and in no event [***] and (ii)
MedImmune will pay to Micromet any and all damages determined by such arbitrator
in such proceeding; provided, however, that in any event such payment will not
exceed [***].  In any determination of whether MedImmune committed a material
breach, the arbitrator also will take into consideration the scope and extent to
which MedImmune performed such obligations under this Agreement and the extent
of the benefits received by Micromet with respect to such performance.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
12.4         Limitation on Termination Rights.  Each Party will only have the
rights described above in this Article 12 with regard to the termination of one
or more provisions of this Agreement and [***].
 
13.
Effects of Expiration or Termination

 
13.1         Accrued Rights.  Expiration or termination of this Agreement will
be without prejudice to any rights that will have accrued to the benefit of a
Party prior to the effective date of such expiration or termination.  Such
expiration or termination will not relieve a Party from obligations that are
expressly indicated to survive the expiration or termination of this Agreement
 
13.2         Survival.  [***] together with any definitions used or exhibits
referenced therein, will survive expiration of this Agreement.  Notwithstanding
termination of a Party’s rights or obligations under the Articles or Sections
[***], the rights and obligations of the Parties under the other Articles and
Sections of this Agreement will remain in full force and effect.  For the
avoidance of doubt, except as provided in Section 12.3(a), Micromets obligations
to pay upfront fees, milestones (subject to Section 12.3(b)) and royalties under
Article 8 will continue in full force and effect throughout the Royalty Term.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
13.3        Effect of Expiration on Intellectual Property.  Upon expiration of
this Agreement pursuant to Section 12.1 above, the licenses and sublicensing
rights granted in Section 6.1 by MedImmune to Micromet will become fully paid,
perpetual, and irrevocable.
 
13.4        Effect of Termination.  Upon termination of this Agreement, the
rights and obligations of the Parties under this Agreement will be terminated,
except as provided in Section 13.2, and Micromet covenants and agrees to
discontinue and to cause its Affiliates and licensees to discontinue any and all
use of MedImmune Collaboration Technology and/or MedImmune Process Technology
and/or Independent MedImmune Technology and/or Media Materials.
 
14. 
Indemnification and Insurance

 
14.1        Indemnification of MedImmune.  Micromet will indemnify MedImmune and
its Affiliates, and their respective directors, officers, and employees (each, a
“MedImmune Indemnitee”), and defend and save each of them harmless from and
against any and all losses, damages, liabilities, costs and expenses (including
reasonable attorneys’ fees and expenses) in connection with any and all
liability suits, investigations, claims or demands (collectively, “Losses”)
arising from or occurring as a result of any claim or lawsuit by a Third Party
against a MedImmune Indemnitee, to the extent caused by or arising out of: (a)
negligence or willful misconduct on the part of Micromet, its Affiliates or
licensees in performing any activity contemplated by this Agreement, or (b) the
development or Commercialization of Licensed Product in the Territory by
Micromet, its Affiliates or licensees; or (c) the use by Micromet, its
Affiliates or licensees of any Know-How provided under this Agreement or Patents
licensed under this Agreement, in each case, excluding any Losses to the extent
that such Losses arise out of the negligence or willful misconduct of a
MedImmune Indemnitee.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
14.2        Notice of Claim.  All indemnification claims in respect of any
MedImmune Indemnitee under Section 14.1 (collectively, the “Indemnitees” and
each an “Indemnitee”) will be made solely by MedImmune (the “Indemnified
Party”).  The Indemnified Party will give Micromet (the “Indemnifying Party”)
prompt written notice (an “Indemnification Claim Notice”) of any Losses or
discovery of fact upon which such Indemnified Party intends to base a request
for indemnification under Section 14.1, but in no event will the Indemnifying
Party be liable for any Losses that result from any delay in providing such
notice.  Each Indemnification Claim Notice must contain a description of the
claim and the nature and amount of such Loss (to the extent that the nature and
amount of such Loss are known at such time).  The Indemnified Party will furnish
promptly to the Indemnifying Party copies of all papers and official documents
received in respect of any Losses.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
14.3        Control of Defense.  At its option, the Indemnifying Party may
assume the defense of any claim subject to indemnification as provided for in
Section 14.1 (each, a “Third Party Claim”) by giving written notice to the
Indemnified Party within [***] days after the Indemnifying Party’s receipt of an
Indemnification Claim Notice.  Upon assuming the defense of a Third Party Claim,
the Indemnifying Party may appoint as lead counsel in the defense of the Third
Party Claim any legal counsel selected by the Indemnifying Party.  In the event
the Indemnifying Party assumes the defense of a Third Party Claim, the
Indemnified Party will immediately deliver to the Indemnifying Party all
original notices and documents (including court papers) received by any
Indemnitee in connection with the Third Party Claim.  Should the Indemnifying
Party assume the defense of a Third Party Claim, the Indemnifying Party will not
be liable to the Indemnified Party or any other Indemnitee for any legal
expenses subsequently incurred by such Indemnified Party or other Indemnitee in
connection with the analysis, defense or settlement of the Third Party Claim.
 
14.4        Right to Participate in Defense.  Without limiting Section 14.2, any
Indemnitee will be entitled to participate in, but not control, the defense of
such Third Party Claim and to employ counsel of its choice for such purpose;
provided, however, that such employment will be at the Indemnitee’s own expense
unless (i) the employment thereof has been specifically authorized by the
Indemnifying Party in writing, or (ii) the Indemnifying Party has failed to
assume the defense and employ counsel in accordance with Section 14.2 (in which
case the Indemnified Party will control the defense).
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
14.5        Settlement.  With respect to any Losses relating solely to the
payment of money damages in connection with a Third Party Claim and that will
not result in the Indemnitee’s becoming subject to injunctive or other relief or
otherwise adversely affect the business of the Indemnitee in any manner other
than by the payment of money damages, and as to which the Indemnifying Party
will have acknowledged in writing the obligation to indemnify the Indemnitee
hereunder, the Indemnifying Party will have the sole right to consent to the
entry of any judgment, enter into any settlement or otherwise dispose of such
Loss, on such terms as the Indemnifying Party, in its sole discretion, will deem
appropriate, and will transfer to the Indemnified Party all amounts which said
Indemnified Party will be liable to pay prior to the entry of judgment.  With
respect to all other Losses in connection with Third Party Claims, where the
Indemnifying Party has assumed the defense of the Third Party Claim in
accordance with Section 14, the Indemnifying Party will have authority to
consent to the entry of any judgment, enter into any settlement or otherwise
dispose of such Loss provided it obtains the prior written consent of the
Indemnified Party (which consent will be at the Indemnified Party’s sole and
absolute discretion).  The Indemnifying Party will not be liable for any
settlement or other disposition of a Loss by an Indemnitee that is reached
without the written consent of the Indemnifying Party.  Regardless of whether
the Indemnifying Party chooses to defend or prosecute any Third Party Claim, no
Indemnitee will admit any liability with respect to, or settle, compromise or
discharge, any Third Party Claim without the prior written consent of the
Indemnifying Party.
 
14.6        Cooperation.  Regardless of whether the Indemnifying Party chooses
to defend or prosecute any Third Party Claim, the Indemnified Party will, and
will cause each other Indemnitee to, cooperate in the defense or prosecution
thereof and will furnish such records, information and testimony, provide such
witnesses and attend such conferences, discovery proceedings, hearings, trials
and appeals as may be reasonably requested in connection with such Third Party
Claim.  Such cooperation will include access during normal business hours
afforded to the Indemnifying Party to, and reasonable retention by the
Indemnified Party of, records and information that are reasonably relevant to
such Third Party Claim, and making Indemnitees and other employees and agents
available on a mutually convenient basis to provide additional information and
explanation of any material provided hereunder, and the Indemnifying Party will
reimburse the Indemnified Party for all its reasonable and documented
out-of-pocket expenses in connection with such cooperation.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
14.7        Insurance.  During the Term, Micromet will have and maintain such
types and amounts of liability insurance as is normal and customary in the
industry generally for parties similarly situated, and will upon request provide
MedImmune with a complete copy of its policies of insurance in that regard,
along with any amendments and revisions thereto.
 
15.
Representations and Warranties

 
15.1        Mutual Representations and Warranties.  Each Party hereby represents
and warrants to the other Party that, as of the Effective Date:
 
(a)          Such Party (i) has the power and authority to enter into this
Agreement and perform its obligations hereunder, and (ii) has taken all
necessary action on its part required to authorize the execution and delivery of
this Agreement and the performance of its obligations hereunder;
 
(b)          This Agreement has been duly executed and delivered on behalf of
such Party and constitutes a legal, valid and binding obligation of such Party
and is enforceable against it in accordance with its terms subject to the
effects of bankruptcy, insolvency or other laws of general application affecting
the enforcement of creditor rights and judicial principles affecting the
availability of specific performance and general principles of equity, whether
enforceability is considered a proceeding at law or equity;
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(c)          The execution and delivery of this Agreement and the performance of
such Party’s obligations hereunder (i) do not conflict with or violate any
requirement of applicable law or any provision of the articles of incorporation,
bylaws or any similar instrument of such Party in any material way, and (ii) do
not conflict with, violate, or breach or constitute a default or require any
consent under, any contractual obligation or court or administrative order by
which such Party is bound.
 
15.2        Additional Representations and Warranties of Micromet.  Micromet
hereby represents and warrants to MedImmune that Micromet is a corporation duly
organized, validly existing and in good standing under the laws of Germany, and
has full corporate power and authority and the legal right to own and operate
its property and assets and to carry on its business as it is now being
conducted and as it is contemplated to be conducted by this Agreement.
 
15.3        Additional Representations and Warranties of MedImmune.  MedImmune
hereby represents and warrants to Micromet that as of the Effective Date:
 
(a)          MedImmune is a limited liability company duly organized, validly
existing and in good standing under the laws of Delaware, and has full power and
authority and the legal right to own and operate its property and assets and to
carry on its business as it is now being conducted and as it is contemplated to
be conducted by this Agreement;
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(b)          There are no pending claims against MedImmune or to the actual
knowledge of MedImmune any threatened claims against MedImmune that Licensed
Product infringes any Patents of a Third Party;
 
(c)          Exhibit A includes all of the Patents made or generated in
furtherance of and as a direct result of employees, agents or independent
contractors of MedImmune or its Affiliates performing an activity pursuant to
the Collaboration and License Agreement; provided, however, that any Patent
within Collaboration Technology that is not included in Exhibit A will be deemed
automatically included therein and licensed hereunder as of the Effective Date;
and
 
(d)          MedImmune has the right to grant the licenses granted to Micromet
in this Agreement, and MedImmune has no actual knowledge that any of the
Know-How within MedImmune Process Technology has been misappropriated from a
Third Party; and
 
(e)          MedImmune has transferred to Micromet the IND, orphan drug
designations, any amendments thereto, and all regulatory correspondence relating
to the Product that are is in the possession of MedImmune; provided, however,
that MedImmune will not be deemed to be in breach of this subsection (e) if it
provides any additional such regulatory filings or materials in its possession
promptly after receiving a request from Micromet identifying a specific
regulatory filing or document.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(f)           As of the Effective Date, MedImmune is not exclusively licensed
under a license agreement with a Third Party under any claims of a Patent that
claim only a process for manufacturing a BiTE Molecule which patent MedImmune
has the right to sublicense to Micromet without violating the terms of an
agreement or arrangement with such Third Party; provided, however, that
MedImmune will not be deemed to be in breach of this subsection (f) if MedImmune
has such a license and, upon request of Micromet, grants Micromet a sublicense
with respect to Licensed Product of the scope set forth under Section 6.1(a) of
this Agreement, but only to the extent permitted by and in accordance with the
terms of such license agreement and further provided that Micromet is obligated
to make any and all payments and royalties due to such Third Party as a result
of granting of and/or exercising rights granted under such sublicense, including
but not limited to milestones and royalties.
 
16.
Disclaimer; Limitation of Liability

 
16.1        Disclaimer of Warranty. EXCEPT FOR THE EXPRESS WARRANTIES SET FORTH
IN THIS AGREEMENT, MEDIMMUNE AND MICROMET MAKE NO REPRESENTATIONS AND GRANT NO
WARRANTIES, EXPRESS OR IMPLIED, EITHER IN FACT OR BY OPERATION OF LAW, BY
STATUTE OR OTHERWISE, AND MEDIMMUNE AND MICROMET EACH SPECIFICALLY DISCLAIM ANY
OTHER WARRANTIES, WHETHER WRITTEN OR ORAL, EXPRESS, STATUTORY OR IMPLIED,
INCLUDING ANY WARRANTY OF QUALITY, MERCHANTABILITY OR FITNESS FOR A PARTICULAR
USE OR PURPOSE OR ANY WARRANTY AS TO THE VALIDITY OF ANY PATENTS OR THE
NON-INFRINGEMENT OF ANY INTELLECTUAL PROPERTY RIGHTS OF THIRD PARTIES, AND
MEDIMMUNE MAKES NO REPRESENTATIONS OR WARRANTIES WITH RESPECT TO THE
MANUFACTURING PROCESS OR MANUFACTURING PROCESS TECHNOLOGY PROVIDED TO MICROMET.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
16.2        Limitation of Liability.  (a) IN NO EVENT WILL EITHER PARTY BE
LIABLE FOR LOST PROFITS, LOSS OF DATA, OR FOR ANY SPECIAL, INDIRECT, INCIDENTAL,
CONSEQUENTIAL OR PUNITIVE DAMAGES, HOWEVER CAUSED, ON ANY THEORY OF LIABILITY
AND WHETHER OR NOT SUCH PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH
DAMAGES, ARISING UNDER ANY CAUSE OF ACTION AND ARISING IN ANY WAY OUT OF THIS
AGREEMENT.  THE FOREGOING LIMITATIONS WILL NOT APPLY TO AN AWARD OF ENHANCED
DAMAGES AVAILABLE UNDER THE PATENT LAWS FOR WILLFUL PATENT INFRINGEMENT AND WILL
NOT LIMIT EITHER PARTY’S LIABILITY AND OBLIGATIONS TO THE OTHER PARTY UNDER
SECTIONS 10 AND 14.
 
(b)          EXCEPT AS PROVIDED IN SECTION 12.3(a) AND SUBJECT TO SECTION
16.2(a), IN NO EVENT WILL MEDIMMUNE BE LIABLE TO MICROMET IN AN AMOUNT THAT
EXCEEDS THE PAYMENTS RECEIVED BY MEDIMMUNE FROM MICROMET UNDER THIS AGREEMENT.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
17.
Miscellaneous

 
17.1        Force Majeure.  Neither Party will be held liable or responsible to
the other Party or be deemed to have defaulted under or breached this Agreement
for failure or delay in fulfilling or performing any term of this Agreement when
such failure or delay is caused by or results from events beyond the reasonable
control of the non-performing Party, including fires, floods, embargoes,
shortages, epidemics, quarantines, war, acts of war (whether war be declared or
not), insurrections, riots, civil commotion, strikes, lockouts or other labor
disturbances, acts of God or acts, omissions or delays in acting by any
governmental authority.  The non-performing Party will notify the other Party of
such force majeure within [***] after such occurrence by giving written notice
to the other Party stating the nature of the event, its anticipated duration,
and any action being taken to avoid or minimize its effect.  The suspension of
performance will be of no greater scope and no longer duration than is necessary
and the non-performing Party will use commercially reasonable efforts to remedy
its inability to perform; provided, however, that in the event the suspension of
performance continues for [***] after the date of the occurrence, the Party not
affected by such force majeure may terminate this Agreement immediately upon
written notice to the other Party.
 
17.2        Assignment.  Neither Party will sell, transfer, assign, delegate,
pledge or otherwise dispose of, whether voluntarily, involuntarily, by operation
of law or otherwise, this Agreement or any of its rights or duties under this
Agreement without the prior written consent of the other Party, which consent
will not be withheld or delayed unreasonably; provided, however, that either
Party may assign or transfer this Agreement or any of its rights or obligations
under this Agreement without the consent of the other Party (a) to any Affiliate
of such Party, or (b) to any Third Party with which it merges or consolidates,
or to which it transfers all or substantially all of its assets to which this
Agreement relates.  The assigning Party (unless it is not the surviving entity)
will remain jointly and severally liable with the relevant Affiliate or Third
Party assignee under this Agreement, and the relevant Affiliate assignee, Third
Party assignee or surviving entity will assume in writing all of the assigning
Party’s obligations under this Agreement.  Any purported assignment or transfer
in violation of this section will be void ab initio and of no force or effect.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
17.3        Severability.  If any provision of this Agreement is held to be
illegal, invalid or unenforceable under any present or future law, and if the
rights or obligations of either Party under this Agreement will not be
materially and adversely affected thereby, (a) such provision will be fully
severable, (b) this Agreement will be construed and enforced as if such illegal,
invalid or unenforceable provision had never comprised a part of this Agreement,
(c) the remaining provisions of this Agreement will remain in full force and
effect and will not be affected by the illegal, invalid or unenforceable
provision or by its severance from this Agreement, and (d) in lieu of such
illegal, invalid or unenforceable provision, there will be added automatically
as a part of this Agreement a legal, valid and enforceable provision as similar
in terms to such illegal, invalid or unenforceable provision as may be possible
and reasonably acceptable to the Parties.
 
17.4        Governing Law; Dispute Resolution.
 
(a)          This Agreement, and any claim, dispute, or controversy of whatever
nature arising out of or relating to this Agreement will be governed by and
construed in accordance with the laws of the State of New York, U.S.A., without
giving effect to any principles of choice of law that would require the
application of the laws of a different state or country.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

--------------------------------------------------------------------------------

 

***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(b)          The Parties will try to settle their differences amicably between
themselves.  If any claim, dispute, or controversy of whatever nature arising
out of or relating to this Agreement, including the performance or alleged
non-performance of a Party of its obligations under this Agreement arises
between the Parties (each a “Dispute”), a Party may notify the other Party in
writing of such Dispute.  If the Parties are unable to resolve the Dispute
within [***] of receipt of the written notice by the other Party, such Dispute
will be referred to the Chief Executive Officers of each of the Parties who will
use their good faith efforts to resolve the Dispute within [***] after such
referral.
 
(c)          If a Dispute is not resolved as provided in the preceding Section
17.4(b), whether before or after termination of this Agreement, the Parties
hereby agree to resolve such Dispute by final and binding arbitration
administered under the rules of arbitration of JAMS by one (1) arbitrator
appointed in accordance with the said Rules, provided that upon request of
either Party, three (3) arbitrators will be appointed.  If the Parties are
unable to mutually select such panel, the panel will be selected in accordance
with the procedures of JAMS.  The decision and award rendered by the panel will
be final and binding.  In any such arbitration, the arbitrators will not have
the right to modify the terms and conditions of this Agreement.  As a result,
the rights and obligations of the Parties will be determined in accordance with
the terms and conditions of this Agreement and any decision or award will be
only in accordance with the terms and conditions of this Agreement.  The Parties
will exert best efforts to have the decision and award rendered within [***]
after the first to occur of (i) notice of breach of this Agreement, which breach
is a subject of the arbitration, and (ii) a notice invoking this arbitration
provision.  Judgment upon the award may be entered in any court having
jurisdiction thereof.  Any arbitration pursuant to this section will be held in
Washington, D.C. or such other place as may be mutually agreed upon in writing
by the Parties.  With respect to any Disputes arising in connection with an
alleged breach of a Party’s rights and obligations with respect to confidential
Know-How or Confidential Information received from the other Party, the
arbitrator will apply the discovery provisions of the Federal Rules of Civil
Procedure.  This means that depositions may be taken and full discovery may be
obtained in any arbitration commenced under this Section 17.4 with respect to
such Disputes.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

--------------------------------------------------------------------------------

 

***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
(d)          Notwithstanding the provisions of this Section 17.4, either Party
will have the right to seek temporary or permanent injunctive relief in any
court of competent jurisdiction as may be available to such Party under the laws
and rules applicable in such jurisdiction.  Further, the provisions of this
Section 17.4 will not apply with respect to any claim of a Party that the other
Party is infringing any of its patents.
 
17.5        Notices.  All notices or other communications that are required or
permitted hereunder will be in writing and delivered personally, sent by
facsimile (and promptly confirmed by personal delivery or overnight courier as
provided in this Agreement), or sent by internationally-recognized overnight
courier addressed as follows:
 
If to MedImmune, to:
 
MedImmune, LLC.
One MedImmune Way
Gaithersburg, MD  20878, USA
Attention:  Legal Department
Facsimile:  (301) 398-9625

*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

--------------------------------------------------------------------------------

 

***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2

If to Micromet, to:

Micromet AG
Staffelseestrasse 2
81477 Munich
Germany
Attention: Chief Executive Officer
Facsimile: ++49 89 895 277 205

With a copy to:

Micromet, Inc.
6707 Democracy Blvd.
Suite 505
Bethesda, MD 20817
Attention: General Counsel
Facsimile: 240-752-1425
 
or to such other address as the Party to whom notice is to be given may have
furnished to the other Party in writing in accordance with this Agreement.  Any
such communication will be deemed to have been given (i) when delivered, if
personally delivered or sent by facsimile on a business day, and (ii) on the
second business day after dispatch, if sent by internationally-recognized
overnight courier.  It is understood and agreed that this Section 17.5 is not
intended to govern the day-to-day business communications necessary between the
Parties in performing their duties, in due course, under the terms of this
Agreement.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

--------------------------------------------------------------------------------

 

***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
17.6        Entire Agreement; Modifications.  This Agreement (including any
Exhibits, Schedules, or other attachments hereto, each of which is hereby
incorporated by reference herein) sets forth and constitutes the entire
agreement and understanding between the Parties with respect to the subject
matter of this Agreement and all prior agreements, understanding, promises and
representations, whether written or oral, with respect thereto are superseded by
this Agreement except to the extent expressly referenced herein, including the
Collaboration and License Agreement and the Related Agreements; provided,
however, that no agreement between the Parties executed contemporaneously with
this Agreement will be so superseded by this Agreement.  Each Party confirms
that it is not relying on any representations or warranties of the other Party
except as specifically set forth in this Agreement.  No amendment or
modification of this Agreement will be binding upon the Parties unless in
writing and duly executed by authorized representatives of both Parties.
 
17.7        Relationship of the Parties.  It is expressly agreed that the
relationship between the Parties is and will be that of independent contractors,
and that the relationship between the Parties will not constitute a partnership,
joint venture or agency.  Neither Party will have the authority to make any
statements, representations or commitments of any kind, or to take any action,
which will be binding on the other, without the prior written consent of the
other to do so.  All persons employed by a Party will be employees of such Party
and not of the other Party and all costs and obligations incurred by reason of
any such employment will be for the account and expense of such Party.
 
17.8        Waiver.  Any term or condition of this Agreement may be waived at
any time by the Party that is entitled to the benefit of such term or condition,
but no such waiver will be effective unless set forth in a written instrument
duly executed by or on behalf of the Party waiving such term or condition.  The
waiver by either Party of any right under this Agreement or of claims based on
the failure to perform or a breach by the other Party will not be deemed a
waiver of any other right under this Agreement or of any other breach or failure
by said other Party whether of a similar nature or otherwise.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
17.9        Counterparts.  This Agreement may be executed in counterparts, each
of which will be deemed an original, but all of which together will constitute
one and the same instrument.
 
17.10      No Benefit to Third Parties.  The representations, warranties,
covenants and agreements set forth in this Agreement are for the sole benefit of
the Parties hereto and their successors and permitted assigns, and they will not
be construed as conferring any rights on any other parties.
 
17.11      Further Assurance.  Each Party will duly execute and deliver, or
cause to be duly executed and delivered, such further instruments and do and
cause to be done such further acts and things, including the filing of such
assignments, agreements, documents and instruments, as may be necessary or as
the other Party may reasonably request in connection with this Agreement or to
carry out more effectively the provisions and purposes, or to better assure and
confirm unto such other Party its rights and remedies under this Agreement.
 
17.12      English Language.  This Agreement has been written and executed in
the English language.  Any translation into any other language will not be an
official version hereof, and in the event of any conflict in interpretation
between the English version and such translation, the English version will
control.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
17.13      Non-Solicitation.  During the [***] following the Effective Date,
Micromet will not solicit the employment of any individual who, at the time of
such solicitation is an employee of MedImmune.  For the avoidance of doubt, this
Section 17.13 will not apply to general solicitations through public media,
websites and the like, and will not apply with respect to individuals who are
[***], or to individuals who first approach Micromet regarding job
opportunities.
 
17.14      Construction.  Except where the context otherwise requires, wherever
used, the singular will include the plural, the plural the singular, the use of
any gender will be applicable to all genders, and the word “or” is used in the
inclusive sense (and/or).  The captions of this Agreement are for convenience of
reference only and in no way define, describe, extend or limit the scope or
intent of this Agreement or the intent of any provision contained in this
Agreement.  The term “including” as used herein means including, without
limiting the generality of any description preceding such term.  References to
“Section” or “Sections” are references to the numbered sections of this
Agreement, unless expressly stated otherwise.
 
[Remainder of this page is left blank intentionally]
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
IN WITNESS WHEREOF, the Parties hereto have caused this Agreement to be executed
by their duly authorized representatives as of the date first above written.
 
Micromet AG
 
MedImmune, LLC
                   
By:
 /s/ Jens Hennecke  
By:
/s/ Peter Greenloaf          
Name:
Jens Hennecke  
Name:
Peter Greenloaf          
Title:
SVP Business Development  
Title:
SVP Commerical Corp Dev.          
By:
 /s/ Patrick Baeuerle                
Name:
Patrick Baeuerle                
Title:
CSO, SVP R&D      

 
[Signature Page to the Termination and License Agreement]
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
Exhibit A
 
Patents within MedImmune Collaboration Technology
 
[***]
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
Exhibit B
 
MT103 Sequence
 
[***]
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
Exhibit C
 
Services
 
Scope of Work & Budget for Studies
 
A.        [***]
 
Stability  Protocol
 
Lot #
 
Timing
 
Estimated Cost
[***]
 
[***]
       
[***]
 
[***]
       
[***]
 
[***]
       
[***]
 
[***]
       
[***]
 
[***]
       
[***]
 
[***]
       
[***]
 
[***]
       
[***]
 
[***]
 
[***]
 
[***]
[***]
 
[***]
       
[***]
 
[***]
       
[***]
 
[***]
       
[***]
 
[***]
       
[***]
 
[***]
       
[***]
 
[***]
       
[***]
 
[***]
       

 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.

 
 

--------------------------------------------------------------------------------

 
 
 
***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
B.           [***]

Description of Study
 
Timing
 
Estimated Costs
[***]
 
[***]
 
[***]

C.           [***]

Description of Study
 
Timing
 
Estimated Costs
[***]
 
[***]
 
[***]

*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

--------------------------------------------------------------------------------

 
***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
Exhibit D
Clinical Materials

[***] 

*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

--------------------------------------------------------------------------------

 
***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
Exhibit E-1

Clinical and Non-Clinical Documentation

Clinical Documentation

·
[***]

·
[***]

Non-Clinical Documentation

[***]
The information and documentation listed above will be transferred to Micromet
within [***] from the Effective Date.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

--------------------------------------------------------------------------------

 
***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
Exhibit E-2
  
Documents and Material previously transferred to Micromet*

Clinical Documentation

[***]
Regulatory

[***]
INN

[***]
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

--------------------------------------------------------------------------------

 
***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
Exhibit E-3

Documents to be transferred to Micromet

   
Document Title
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*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
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*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
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*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
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*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
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*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
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*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

--------------------------------------------------------------------------------

 
***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
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*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

--------------------------------------------------------------------------------

 
***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
Exhibit F

Form of Confidentiality Agreement

This Confidentiality (“Agreement”) is effective as of __________ __,
____(“Effective Date”), between MedImmune, LLC, having a place of business at
One MedImmune Way, Gaithersburg, MD 20878 (“MedImmune”) and
__________________________________, having a place of business at
___________________________________________________________ (“Company”).
MedImmune and Company may be referred to herein individually as a “Party” and
collectively as the “Parties.”

WHEREAS, MedImmune and Micromet AG (“Micromet”) have entered into a Termination
and License Agreement, effective November 4, 2009, to terminate MedImmune’s
rights in MT103 (as defined below) and as such MedImmune has agreed to transfer
its manufacturing  process for MT103 to a contract manufacturing organization
(“CMO”) on behalf on Micromet;

 
WHEREAS, Company, on behalf of Micromet, has been selected as the CMO for MT103;

WHEREAS, MedImmune will provide MedImmune Property (as defined below) to Company
solely for the limited purpose of the technology transfer and establishment of a
manufacturing process and/or manufacture of MT103 Product at Company’s
facilities in its capacity as a CMO for Micromet (“Purpose”); and

WHEREAS, MedImmune is willing to disclose the MedImmune Property on the
condition that it be maintained in strict secrecy and confidence and not be used
for any purpose other than the Purpose.

NOW, THEREFORE, in consideration of the foregoing premises and the mutual
covenants herein contained, the receipt and sufficiency of which are hereby
acknowledged, the Parties agree as follows.
1.
Definitions and Interpretation.

 
1.1          Definitions.  Capitalized terms used in this Agreement shall have
the meaning ascribed to them in this Section 1.1 or as otherwise defined in the
preamble or recitals above or the text of this Agreement following this
Section 1.1.
 
“MT103 Product” means MT103 alone or as part of a composition or formulation
containing MT103.
 
“MedImmune Property" means any Know-How of MedImmune or any other information of
MedImmune, in each case provided to Company by or on behalf of MedImmune and/or
by or on behalf of Micromet.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

--------------------------------------------------------------------------------

 
***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
“Know-How” means (a) any scientific or technical information, results and data
of any type whatsoever, in any tangible or intangible form whatsoever, including
databases, practices, methods, techniques, specifications, formulations,
formulae, knowledge, know-how, skill, experience, test data including
pharmacological, medicinal chemistry, biological, chemical, biochemical,
toxicological and clinical test data, analytical and quality control data,
stability data, studies and procedures, and manufacturing process and
development information, results and data, which Know-How includes but is not
limited to fermentation processes, recovery steps, process validation, product
identity assays, in process control assays, the formulation and/or components of
Media Materials, relevant standard operating procedures, and technical methods
for assays and (b) any biological, chemical, or physical materials, including
but not limited to working cell banks and Media Materials ("Materials").
 
“Media Materials” shall mean the cell culture media and nutrient feeds used in
the Manufacturing Process.
 
“Manufacturing Process” shall mean the process for manufacturing or producing
MT103 alone or as part of a composition or formulation.
 
“MT103” shall mean the BiTE Product containing the BiTE Molecule with the amino
acid sequence set forth in Exhibit B of the Termination and License Agreement
(as referenced above).  Such BiTE Molecule is currently known as blinatumomab.

1.2          Other Interpretive Matters.
(a)           Unless the context requires otherwise, (i) words in the singular
include the plural and vice versa, (ii) the term “includ(ing)(es)” means
“includ(ing)(es) without limitation,” and (iii) the terms “herein,” “hereof,”
“hereunder” and words of similar import shall mean references to this Agreement
as a whole and not to any individual Section or portion of this Agreement.  All
references to “day” or “days” shall mean calendar days unless otherwise noted.
 
(b)           No provision of this Agreement will be interpreted in favor of, or
against, either of the Parties by reason of the extent to which any such Party
or its counsel participated in the drafting thereof or by reason of the extent
to which any such provision is inconsistent with any prior draft of this
Agreement or such provision.
 
(c)           The captions to the several Articles and Sections hereof are not a
part of the Agreement, but are merely for convenience to assist in locating and
reading the several Articles and Sections of this Agreement.
 
2.
Duties.

 
2.1          Disclosure and Use Restrictions.  Except as expressly provided
herein, Company agrees that without limitation as to time and subject to
Sections 3.1 and 3.2, Company and its Affiliates will keep completely
confidential and will not publish or otherwise disclose any MedImmune Property
and/or provide a third party with MedImmune Property and will use MedImmune
Property including but not limited to Media Materials only for the Purpose.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

--------------------------------------------------------------------------------

 
***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
2.2          Restrictions Regarding Physical Prototypes.  Company shall not
sequence, reverse engineer, copy, dissemble, obtain the recipe or components or
otherwise attempt to reconstruct any physical embodiments of the Media
Materials.  Notwithstanding anything to the contrary, in the event Company, its
Affiliates, subcontractors, or licensees ascertains or receives the recipe of
any Media Material through no fault of its own, such recipe will still be
considered Confidential Information herein and Company will inform and cause its
Affiliates, subcontractors, or licensees to promptly inform MedImmune of such
event and destroy such information.
 
3.
Exceptions and Other Matters.

 
3.1          Exclusions  Notwithstanding the foregoing, any MedImmune Property
will not be deemed MedImmune Property for purposes of this Agreement if such
MedImmune Property:
 
 
(1)
was already known or available to Company, other than under an obligation of
confidentiality or non-use, at the time of disclosure to Company;

 
 
(2)
was generally available or known to parties reasonably skilled in the field to
which such information pertains, or was otherwise part of the public domain, at
the time of its disclosure to the Company;

 
 
(3)
became generally available or known to parties reasonably skilled in the field
to which such information pertains, or otherwise became part of the public
domain, after its disclosure to the Company through no fault of or breach of its
obligations under Article 2 by the Company;

 
 
(4)
was disclosed to the Company, other than under an obligation of confidentiality
or non-use, by a Third Party who had no obligation to MedImmune not to disclose
such information to others; or

 
 
(5)
was independently discovered or developed by the Company or its Affiliates, as
evidenced by their written records, without the use of, and by personnel who had
no access to MedImmune Property.

 
3.2          Authorized Disclosures.  Company may disclose MedImmune Property to
the extent that such disclosure is:
 
 
(1)
made in response to a valid order of a court of competent jurisdiction or other
governmental or regulatory body of competent jurisdiction; provided, however,
that the Company will first have given notice to MedImmune and given MedImmune a
reasonable opportunity to quash such order and to obtain a protective order
requiring that the MedImmune Property and documents that are the subject of such
order be held in confidence by such court or governmental or regulatory body or,
if disclosed, be used only for the purposes for which the order was issued; and
provided, further, that if a disclosure order is not quashed or a protective
order is not obtained, the MedImmune Property disclosed in response to such
court or governmental order will be limited to that information which is legally
required to be disclosed in response to such court or governmental order; or

 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

--------------------------------------------------------------------------------

 
***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
 
(2)
otherwise required by law, rule, or regulation; provided, however, that the
Company will provide MedImmune with notice of such disclosure in advance thereof
to the extent practicable.

 
3.3           No Representation or Warranty by MedImmune.  MedImmune makes no
express or implied representation or warranty as to the accuracy, completeness
or utility of the MedImmune Property.
 
3.4           Ownership; Return/Destruction.  All MedImmune Property is and
shall remain the sole and exclusive property of MedImmune.  Company agrees that
upon its termination as a CMO by Micromet related to the Purpose, within twenty
(20) days thereafter, Company shall:  (a) cease any use of the Materials,
including any Media Materials, and all copies of the foregoing or any portion
thereof, in whatever form or medium stored, and (b) transfer all MedImmune
Property, including all documents, samples, summaries, extracts, records or
other materials that contain any of the MedImmune Property, in whatever form or
medium stored, to Micromet or its designee, and such designee shall be subject
to legally binding nondisclosure and use restrictions that are at least as
restrictive as the terms of this Agreement, and (c) upon completion of such
transfer, certify in writing that such transfer is complete.
 
3.5           No License Implied.  This Agreement shall not be construed to
grant to Company any license, expressed or implied, or other rights with respect
to the MedImmune Property.
 
3.6           Indemnification by Company.  Company will indemnify MedImmune and
its Affiliates, and their respective directors, officers, and employees (each, a
“MedImmune Indemnitee”), and defend and save each of them harmless from and
against any and all losses, damages, liabilities, costs and expenses (including
reasonable attorneys’ fees and expenses) in connection with any and all
liability suits, investigations, claims or demands (collectively, “Losses”)
arising from or occurring as a result of any claim or lawsuit by a third party
against a MedImmune Indemnitee, to the extent caused by or arising out of: (a)
negligence or willful misconduct on the part of Company, or its Affiliates,
representatives or agents in performing any activity related to the Purpose, or
(b) the manufacture or production of MT103 Product by Company, its Affiliates,
representatives or agents; or (c) the use of MedImmune Property by or on behalf
of Company or its Affiliates, agents or representatives; in each case, excluding
any Losses to the extent that such Losses arise out of the negligence or willful
misconduct of a MedImmune Indemnitee.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

--------------------------------------------------------------------------------

 
***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
3.7           Use of Name.  Neither Party will make public use of the other
Party’s name except (a) in connection with announcements and other permitted
disclosures relating to this Agreement and the activities contemplated hereby,
(b) as required by applicable law, rule, or regulation, and (c) otherwise as
agreed in writing by such other Party.
 
4.
Termination.

 
4.1           Termination.  MedImmune may terminate this Agreement for any or no
reason upon thirty (30) days advance written notice to Company.  Expiration or
termination of this Agreement for any reason shall be without prejudice to any
rights that shall have accrued to the benefit of a Party or the Parties prior to
such expiration or termination, and shall not relieve the Parties of any
obligations that have accrued to the other Party prior to such expiration or
termination.
 
4.2           Survival.  Company’s obligations, agents or representations under
Articles 2, 3, and 5 and this Section 4.2 shall survive termination of this
Agreement.
 
5.
Miscellaneous.

 
5.1           Assignment.  Company will not sell, transfer, assign, delegate,
pledge or otherwise dispose of, whether voluntarily, involuntarily, by operation
of law or otherwise, this Agreement or any of its rights or duties under this
Agreement without the prior written consent of MedImmune, which consent will not
be withheld or delayed unreasonably; provided, however, that Company may assign
or transfer this Agreement or any of its rights or obligations under this
Agreement without the consent of MedImmune (a) to any Affiliate of such Party,
or (b) to any third party with which it merges or consolidates, or to which it
transfers all or substantially all of its assets to which this Agreement
relates.  MedImmune may assign this Agreement without the consent of Company by
written notice to Company.  The assigning Party (unless it is not the surviving
entity) will remain jointly and severally liable with the relevant Affiliate or
third party assignee under this Agreement, and the relevant Affiliate assignee,
third party assignee or surviving entity will assume in writing all of the
assigning Party’s obligations under this Agreement.  Any purported assignment or
transfer in violation of this section will be void ab initio and of no force or
effect.
 
5.2           Applicable Law.  This Agreement, and any claim, dispute, or
controversy of whatever nature arising out of or relating to this Agreement will
be governed by and construed in accordance with the laws of the State of New
York, U.S.A., without giving effect to any principles of choice of law that
would require the application of the laws of a different state or country.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

--------------------------------------------------------------------------------

 
***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
5.3           Compliance with Laws; Export Controls.  Company shall comply with
all applicable laws, rules and regulations arising in connection with this
Agreement and its use of the MedImmune Property.  Without limiting the
foregoing, this Agreement is made subject to any restrictions under the export
control laws, rules and regulations concerning the export of products, materials
or technical information either from the United States of America or to a
foreign national within the United States of America (e.g., a “deemed export”
applying to transfers solely within the United States of America) which may be
imposed upon or related to Company from time to time by the government of the
United States of America.  In connection therewith, Company agrees that it will
not export, directly or indirectly, technical information provided or arising
under this Agreement or any materials or products using or embodying such
technical information to any country or foreign national for which the United
States government or any agency thereof at the time of export requires an export
license or other governmental approval, without first obtaining the written
consent to do so from the Department of Commerce or other agency of the United
States government when required by an applicable statute or regulation.
 
5.4           Notices.  Each notice required or permitted hereunder shall be in
writing and sufficient if delivered personally, sent by a nationally-recognized
overnight courier or sent by registered or certified mail, postage prepaid,
return receipt requested, to the Parties at the addresses indicated in the
introductory paragraph of this Agreement, to the attention of the signatories
below.  Either Party may change its address by giving the other party written
notice, delivered in accordance with this Section 5.4.
 
5.5           Waivers and Amendments; Preservation of Remedies.  This Agreement
may be amended, modified, superseded, canceled, renewed or extended, and the
terms and conditions hereof may be waived, only by a written instrument signed
by the Parties or, in the case of a waiver, the Party waiving compliance.  No
delay on the part of any Party in exercising any right, power or privilege
hereunder shall operate as a waiver thereof, nor shall any waiver on the part of
any Party of any right, power or privilege hereunder, nor any single or partial
exercise of any right, power or privilege hereunder, preclude any other or other
exercise thereof hereunder.  The rights and remedies herein provided are
cumulative and are not exclusive of any rights or remedies which any Party may
otherwise have at law or in equity.
 
5.6           Injunctive Relief.  Company acknowledges that:  (a) the covenants
and the restrictions contained in this Agreement are an inducement to MedImmune
to enter into this Agreement and are necessary and required for the protection
of MedImmune; (b) such covenants and restrictions relate to matters that are of
a special, unique and extraordinary character that give each of such covenants a
special, unique and extraordinary value; and (c) a breach of any of such
covenants or restrictions may result in irreparable harm and damages to
MedImmune in an amount difficult to ascertain and which cannot be adequately
compensated by a monetary award.  Accordingly, in addition to any of the relief
to which MedImmune shall be entitled under this Agreement, at law or in equity,
MedImmune shall be entitled to seek temporary and permanent injunctive relief
from any breach or threatened breach of such covenants or restrictions without
proof of actual damages that have been or may be caused to MedImmune by such
breach or threatened breach.  In the event an action for injunctive relief is
brought by MedImmune, Company waives any right to require MedImmune to post any
bond or other security with the court in connection therewith.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
5.7           Independent Relationship.  Company and MedImmune are independent
contractors.  The relationship between the two Parties does not constitute a
partnership, joint venture or agency and shall not be construed as
such.  Neither Company nor MedImmune has any authority to make any statements,
representations or commitments of any kind, or to take any action that is
binding on the other Party.
 
5.8           Entire Agreement.  This Agreement constitutes the entire
understanding of the Parties with respect to the subject matter hereof.  All
express or implied agreements and understandings, either oral or written, with
regard to the services to be performed hereunder are superseded by the terms of
this Agreement.
 
5.9           Severability.  If any one or more provisions of this Agreement is
held invalid, illegal or unenforceable in any respect by a court having
competent jurisdiction, the validity, legality and enforceability of this
Agreement and the remaining provisions contained herein shall not in any way be
affected or impaired thereby, unless the absence of the invalidated provision(s)
adversely affects the substantive rights of the Parties.  The Parties shall in
such instance use their best efforts to replace the invalid, illegal or
unenforceable provision(s) with valid, legal and enforceable provision(s) which,
insofar as practical, implement the purposes of this Agreement.
 
5.10           Counterparts.  This Agreement may be executed and delivered by
any means and in any number of counterparts, each of which shall be an original
as against either Party whose signature appears thereon, but all of which taken
together shall constitute but one and the same instrument.
 
{ Signature page follows. }
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2

 
IN WITNESS WHEREOF, the Parties have executed this Agreement to be effective as
of the Effective Date.

 
MEDIMMUNE, LLC
     
By:
   
Name:
   
Title:
       
[NAME OF COMPANY]
     
By:
   
Name:
   
Title:
 

 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
Exhibit G

Press Release

Micromet Buys Out MedImmune’s Remaining Rights to Blinatumomab
 
BETHESDA, MD, <<Date>>— Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical
company developing novel, proprietary antibodies for the treatment of cancer,
inflammation and autoimmune diseases, today announced that it has signed an
agreement with MedImmune, LLC to buy out MedImmune’s rights to blinatumomab in
North America, and to terminate the collaboration agreement signed in 2003 under
which MedImmune had been granted the right to develop and commericalize
blinatumomab in North America.  As a result of this transaction, Micromet now
controls global rights to develop and commercialize blinatumomab.

In March 2009, MedImmune returned the North American rights to develop and
commercialize blinatumumab to Micromet, but retained an option to reacquire the
right to commercialize blinatumomab in North America. Under the terms of the
termination agreement, Micromet has now regained MedImmune’s remaining rights
relating to blinatumomab as well as any other BiTE antibodies binding to
antigens relevant for hematological cancers that had been reserved for MedImmune
under the terminated agreement.  Micromet will make upfront, milestone, and
royalty payments to MedImmune related to the development and North American net
sales of blinatumomab.

“The advancement of blinatumomab in the clinic is the top priority for
Micromet,” said Micromet CEO Christian Itin. “With complete control over global
development and commercialization of blinatumomab, Micromet can develop an
integrated clinical and regulatory strategy across multiple commercial
territories, starting with the first pivotal study that we expect to initiate in
2010.”

Blinatumomab is a novel therapeutic antibody that activates a patient's T cells
to seek out and destroy lymphoma and leukemia cells. At the recent meeting of
the European Hematological Association (EHA), Micromet announced that
blinatumomab had achieved its primary endpoint in an ongoing phase 2 clinical
trial in ALL patients. Micromet intends to initiate a pivotal trial of
blinatumomab in ALL patients next year.

About Micromet, Inc.
Micromet, Inc. is a biopharmaceutical company developing novel, proprietary
antibodies for the treatment of cancer, inflammation and autoimmune diseases.
Its product development pipeline includes novel antibodies generated with its
proprietary BiTE® antibody platform, as well as conventional monoclonal
antibodies. Two of Micromet’s BiTE antibodies and three of its conventional
antibodies are currently in clinical trials.  Micromet's preclinical product
pipeline includes several novel BiTE antibodies generated with its proprietary
BiTE antibody platform technology.  Micromet’s collaboration partners include
Bayer Schering Pharma, Merck Serono, MedImmune and Nycomed.
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
Forward-Looking Statements

This release contains certain forward-looking statements that involve risks and
uncertainties that could cause actual results to be materially different from
historical results or from any future results expressed or implied by such
forward-looking statements. These forward-looking statements include statements
regarding the development and commercialization of blinatumomab, including the
conduct and timing of future clinical trials involving this product candidate.
You are urged to consider statements that include the words "ongoing," "may,"
"will," "believes," "potential," "expects," "plans," "anticipates," "intends,"
or the negative of those words or other similar words to be uncertain and
forward-looking. Factors that may cause actual results to differ materially from
any future results expressed or implied by any forward-looking statements
include the risk that blinatumomab does not demonstrate safety and/or efficacy
in future clinical trials, the risk that we will not obtain approval to market
blinatumomab and the risks associated with reliance on outside financing to meet
capital requirements. These factors and others are more fully discussed in
Micromet's Quarterly Report on Form 10-Q for the fiscal quarter ended June 30,
2009, filed with the SEC on August 6, 2009, as well as other filings by the
company with the SEC.

# # #

Contact Information
 
US Media:
European Media:
Andrea tenBroek/Chris Stamm
Ludger Wess
(781)-684-0770
+49 (40) 8816 5964
micromet@schwartz-pr.com
ludger@akampion.com
   
US Investors:
European Investors:
Susan Noonan
Ines-Regina Buth
(212) 966-3650
+49 (30) 2363 2768
susan@sanoonan.com
ines@akampion.com

 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

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***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4), and 240.24b-2
 
Exhibit H

Media Materials

Cell Culture Media and Nutrient Feeds

Quantity: Media and nutrient feed sufficient for [***]
Price: Amount corresponding to purchase price paid by MedImmune to the Media
Suppliers
Delivery Term: [***] (Incoterms 2000)
Specifications: As used for the manufacture of the Clinical Materials
 
*** Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as
amended.
 

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