Exhibit 10.1

 

FIRST AMENDMENT

 

to

 

the Collaboration, License and Supply Agreement, dated July 6, 2004

 

by and between

 

Acusphere Inc. (“Acusphere”)

 

and

 

Nycomed Danmark ApS (“Nycomed”)

 

 

This First Amendment (the “First Amendment”), effective as of October 19, 2005,
is entered into by and between Acusphere and Nycomed (the “Parties”).

 

WHEREAS, the Parties entered into a Collaboration, License and Supply Agreement,
dated July 6, 2004 (“the Agreement”); and

 

WHEREAS, the Parties have agreed to make a prepayment to Acusphere of a certain
amount, such amount to be deducted from Nycomed’s next milestone payment under
the Agreement; and

 

WHEREAS, the agreed prepayment amount shall be used by Acusphere to accelerate
the trademark activities related to the Product (as defined in the Agreement);

 

NOW THEREFORE, for good and valuable consideration, the receipt and sufficiency
of which is hereby acknowledged, the Parties agree as follows:

 

 

1.                                       In order to accelerate the trademark
activities related to the Product (as defined in the Agreement), the milestone
payment set forth in Section 4.03(a) shall be reduced by $150,000, and Nycomed
shall pay to Acusphere, as licensing fees, a milestone payment equal to $150,000
on October 24, 2005, such milestone payment to be deemed a milestone payment
paid under Section 4.03 of the Agreement for all purposes of the Agreement.

 

2.                                       Except as otherwise set forth herein,
all of the terms and conditions of the Agreement shall remain in full force and
effect between the Parties.

 

 

IN WITNESS WHEREOF, the Parties hereto have caused this First Amendment to be
executed in duplicate by their duly authorized officers as of the date first
above stated.

 

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ACUSPHERE, INC., 

 

NYCOMED DANMARK ApS 

a Delaware corporation

 

a Danish corporation

 

 

 

 

 

 

 

 

 

 

 

 

By:

 

/s/          Sherri C. Oberg

 

By:

/s/ Håkan Björklund

Name:

Sherri C. Oberg

 

Name:

Håkan Björklund

Title:

President and Chief Executive Officer

 

Title:

Chief Executive Officer, Nycomed Group

 

 

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