Exhibit 10.1

[*] CERTAIN INFORMATION IN THIS EXHIBIT HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE COMMISSION. CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH RESPECT TO
THE OMITTED PORTIONS. ASTERISKS DENOTE SUCH OMISSIONS

ASSET PURCHASE AGREEMENT

THIS ASSET PURCHASE AGREEMENT (this “Agreement”), dated as of September 21,
2011, is made by and among Optos plc, a company incorporated in Scotland with
registered number SC139953 (the “Company”), Optos Inc., a wholly-owned
subsidiary of the Company (the “Buyer”), OPKO Health, Inc., a Delaware
corporation (“OPKO Health”), OPKO Instrumentation, LLC, a Delaware limited
liability company (“Instrumentation”), Ophthalmic Technologies, Inc., an Ontario
corporation (“OTI”) and OTI (UK) Limited, a company incorporated in England
(“OTI UK”, with each of Instrumentation, OTI and OTI UK being referred to as a
“Seller”, and together the “Sellers”).

WHEREAS, the Sellers are engaged in the Business (as defined below);

WHEREAS, the Sellers desire to sell and assign to the Buyer, and the Buyer
desires to purchase and assume from Sellers, substantially all of the assets and
liabilities of the Business, all upon the terms and subject to the conditions
hereinafter set forth;

WHEREAS, in consideration for the Sellers’ and the Buyer’s obligations
hereunder, Company shall guarantee all of the Buyer’s obligations under this
Agreement, including without limitation the assumption of the Assumed
Liabilities and the payment of the Royalty, and OPKO Health shall guarantee all
of the Sellers’ obligations under this Agreement; and

NOW, THEREFORE, in consideration of the mutual covenants herein contained and
for other good and valuable consideration, the receipt and adequacy of which are
hereby acknowledged, the parties hereto hereby agree as follows:

ARTICLE I.

DEFINITIONS

SECTION 1.1. Definitions.

As used in this Agreement, the following terms have the meanings set forth
below:

“Accounts Receivables” means all trade accounts receivable and other rights to
payment from customers of the Business (including any amount in respect of VAT,
sales, transfer or any similar tax payable thereon and trade accounts
receivables from Affiliates of the Sellers), and any claim, remedy or other
right arising out of the foregoing.

“Agreement” has the meaning set forth in the first paragraph of this Agreement.

 

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“Affiliate” means with respect to any Person, any other Person that directly or
indirectly controls or is controlled by, or is under direct or indirect common
control with, such Person. For purposes of this definition, a Person shall be
deemed, in any event, to control another Person if it owns or controls, directly
or indirectly, more than fifty percent (50%) of the voting equity of the other
Person or has the power to direct or cause the direction of the management of
the other Person, whether through ownership of voting securities or otherwise.

“Assumed Liabilities” has the meaning set forth in Section 2.3(a).

“Balance Sheet” means a balance sheet of the Business as at the Balance Sheet
Date.

“Balance Sheet Date” means 31 August 2011.

“Bill of Sale and Assignment and Assumption Agreement” means a bill of sale and
assignment and assumption agreement to be executed and delivered by the Buyer
and the Sellers substantially in the form set forth on Attachment A and
initialed by the parties for the purposes of identification.

“Books and Records” has the meaning set forth in Section 2.1(a)(x).

“Business” means such part of the respective Sellers’ business as relates to the
development, commercialization and sale of ophthalmic diagnostic and imaging
systems and instrumentation products, including the Products, as carried on by
the Sellers as at the date of this Agreement.

“Business Day” means any day other than a Saturday, Sunday or other day on which
banks in the U.S. are permitted or required to close by law or regulation.

“Buyer” has the meaning set forth in the first paragraph of this Agreement.

“Buyer Indemnified Parties” has the meaning set forth in Section 11.2(a).

“Cash Consideration” has the meaning set forth in Section 3.1.

“Circular” has the meaning set forth in Section 8.2.

“Closing” and “Closing Date” have the meaning set forth in Section 4.1.

“Combination Product” has the meaning set forth in the definition of “Net
Sales”.

“Company” has the meaning set forth in the first paragraph of this Agreement.

“Company Products” means products developed by the Company, the Buyer or their
Affiliates that are derived from or based on (in whole or in part) the Products
or the Purchased Assets, or that combine the Products or utilize the Sellers’
Intellectual Property or the Purchased Assets in combination with a Company
widefield retinal scanning device.

“Company Shareholders Meeting” has the meaning set forth in Section 8.1(a).

 

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“Confidential Information” has the meaning set forth in Section 7.7(a)(i).

“Contracts” means contracts, leases, indentures, agreements and all other
legally binding arrangements, whether in existence on the date hereof or
subsequently entered into, whether written or oral, including all amendments
thereto, which relate to the Business or the Purchased Assets.

“Disclosed” means in relation to the representations and warranties given by the
Sellers, disclosed with sufficient explanation to identify in reasonable detail
the nature and scope of the matters disclosed by the Disclosure Schedule.

“Disclosure Documents” means the bundle of documents in the Agreed Form which
accompanies the Disclosure Schedule.

“Disclosure Schedule” means the disclosure schedule together with the Disclosure
Documents having the same date as this Agreement from the Sellers to the Buyer.

“Employee Benefit Plan” means any “employee benefit plan” (as such term is
defined in ERISA §3(3)) and any other material employee benefit plan, program,
arrangement, employee policy, fringe benefit or change of control agreement,
whether or not written.

“Encumbrance” means, with respect to any asset, any imperfection of title,
mortgage, charge, lien, security interest, claim, easement, right of way,
pledge, encumbrance or similar interest of any kind or nature whatsoever
affecting the title to or use of the assets to which they apply.

“Environmental Laws” has the meaning set forth in Section 5.15(a).

“Equipment” has the meaning set forth in Section 2.1(a)(xi).

“Excluded Assets” has the meaning set forth in Section 2.2.

“Excluded Books and Records” has the meaning set forth in Section 2.2(a).

“Excluded Contracts” all contracts, leases, indentures, agreements and all other
legally binding arrangements, whether existing at the date of this Agreement or
subsequently entered into, whether oral or in writing: (i) which relate in whole
or in part to the respective Sellers’ business other than the Business, (ii) the
only parties to which are the Sellers and their Affiliates other than the lease
for the Hialeah Facility, or (iii) contracts which are listed on Schedule
2.2(h).

“Excluded Liabilities” has the meaning set forth in Section 2.3(b).

“FDA” means the U.S. Food and Drug Administration.

“Financial Statements” means (i) the audited consolidated balance sheets of the
Business at 31 December 2010, 2009, and 2008; and (ii) the statements of income
and cash flows of the Business for the fiscal years then ended, as provided to
the Buyer by the Sellers.

 

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“GAAP” means generally accepted accounting principles in the United States.

“Governmental Entity” means any court, administrative agency or commission or
other governmental authority, body or instrumentality, whether U.S. or non-U.S.

“Governmental Rule” means any law, judgment, order, decree, statute, ordinance,
rule or regulation enacted, issued or promulgated by any Governmental Entity.

“Hialeah Facility” means the facility located at 621 W. 20 Street, Hialeah,
Florida 33010.

“Hire Date” has the meaning set forth in Section 8.4(a).

“Hired Employee” has the meaning set forth in Section 8.4(a) but excludes the
Transferring Employees.

“IFRS” has the meaning set forth in Section 5.5(b).

“Indemnification Threshold” has the meaning set forth in Section 11.2(b).

“Indemnitee” has the meaning set forth in Section 11.4(a).

“Indemnitor” has the meaning set forth in Section 11.4(a).

“Instrumentation” has the meaning set forth in the first paragraph of this
Agreement.

“Intellectual Property” means (a) inventions, developments and discoveries
(whether patentable or unpatentable and whether or not reduced to practice), all
improvements thereto, and all patents, patent applications, and patent
disclosures, together with all reissuances, continuations,
continuations-in-part, revisions, extensions, and reexaminations relating
thereto, (b) copyrightable works, all copyrights, and all applications,
registrations, and renewals relating thereto, (c) trade secrets and confidential
business information (including ideas, research and development, Know How,
formulas, compositions, databases, manufacturing and production processes and
techniques, technical data, designs, drawings, specifications, customer and
supplier lists, pricing and cost information, and business and marketing plans
and proposals), (d) computer software (including all data and related
documentation), (e) other proprietary rights, and (f) copies and tangible
embodiments of the foregoing (in whatever form or medium).

“Inventory” has the meaning set forth in Section 2.1(a)(xii).

“Know How” means any know how, trade secrets or Confidential Information of the
Sellers relating to the Business.

“Knowledge” of the Sellers and OPKO Health or the Buyer and the Company (as
applicable) and terms of similar import shall mean (as applicable) the actual
knowledge of the directors and officers of the Sellers and OPKO Health or the
Buyer and the Company.

 

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“Lease Extension Agreement” the agreement evidencing the amendment to the Lease
of the Hialeah Facility to include the additional area used by the Business not
currently included within the terms of that Lease and extending the term of such
Lease to 31 December 2012.

“Leased Real Property” has the meaning set forth in Section 5.11(b).

“Leases” has the meaning set forth in Section 5.11(b).

“Liabilities” means any and all debts, liabilities and obligations, whether
accrued or fixed, absolute or contingent, matured or unmatured, or known or
unknown, including those arising under any Governmental Rule or action and those
arising under any Contract, arrangement, commitment or undertaking, or
otherwise.

“Long Stop Date” has the meaning set forth in Section 10.1(a)(ii).

“Losses” has the meaning set forth in Section 11.2(a).

“Material Adverse Change” means any effect or change, individually or in the
aggregate with all such similar or related changes, that would be materially
adverse to the business, prospects, operations, assets, properties or results of
operations of a party, taken as a whole, or to the ability of any party to
consummate timely the transactions contemplated hereby; provided that none of
the following shall be deemed to constitute, and none of the following shall be
taken into account in determining whether there has been, a Material Adverse
Change: any adverse change, event, development, or effect arising from or
relating to (i) financial, banking, or securities markets (including any
disruption thereof and any decline in the price of any security or any market
index), (ii) changes in any Governmental Rule or GAAP, (iii) general changes in
economic or business conditions, (iv) the negotiation, execution, or
announcement of this Agreement, including any adverse change in customer,
distributor, employee, supplier, or similar relationships arising therefrom or
(v) the taking of any action contemplated by this Agreement and the other
agreements contemplated hereby.

“Maximum Amount” has the meaning set forth in Section 11.2(b).

“Minor Claim” has the meaning set forth in Section 11.2(b).

“Net Sales” shall mean gross amounts invoiced for sales of Products or Company
Products to customers, less the following: (a) payments made or credits allowed
to customers and actually credited to customers for promotional purposes,
allowances, rebates, discounts, profit share payments and other usual and
customary discounts, including, without limitation, volume and prompt payment
discounts, to customers, which are actually received by customers, (b) amounts
repaid or credited by reason of rejections, damages or returns of goods, or
because of retroactive price adjustments, and (c) specific amounts invoiced but
not received following reasonable collection efforts by the Buyer or the Company
as applicable. Only sales of Products and Company Products by the Company, the
Buyer, their Affiliates, distributors and licensees to unrelated parties shall
be deemed Net Sales hereunder. Sales of Product and Company Product between
Company, the Buyer and their Affiliates or sublicensees shall be excluded from
Net Sales. However, sales of Product and Company Product by Affiliates or
sublicensees to unrelated third parties shall be included as Net Sales as if
such sales were made directly by the Company or the Buyer to such unrelated
third parties.

 

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In the event that a Product or Company Product is sold in a combination package
containing such Product or Company Product packaged together in combination with
one or more other products, devices, equipment or components (a “Combination
Product”), Net Sales for such Combination Product will be calculated by
multiplying actual Net Sales of such Combination Product by the fraction A/(A+B)
where A is the selling price of the Product or Company Product as the case may
be if sold separately in finished form and B is the selling price of any other
products, equipment or components in the Combination Product if sold separately
in finished form provided that the selling price of any Combination Product
shall not be less than A+B. In the event that a product containing the Product
or Company Product or one or more of such products, equipment or components in
the Combination Product are not sold separately, then the parties shall
negotiate in good faith a formula for calculating Net Sales for such Combination
Product that reflects the respective contributions of the product containing
Products and Company Products and such other products, equipment or components
to the overall value of such Combination Product. The Buyer and the Company
covenant that they will not intentionally manipulate any part of the fraction
A/(A+B) to avoid or reduce royalty payments or obligations that would otherwise
be due for sales of Product or Company Product in combination form or otherwise.

“Nidek” has the meaning set forth in Section 2.3(b)(vii).

“ * Purchase Orders” means Purchase Order Nos. 09/29/2009, EYECUPS, 0099,
04.22.2010, 04.22.2010, 14.06.2010, 02.08.10, 07132010, 14.06.2010, 24.06.2010,
07.26.10, 072711.

“ * Invoices” means Invoice Nos. 7210, 7230,7179, 7177, 7045, 6490, 7647, 7025,
7258, 7263, 8117 and 7029 issued to * and/or *, in the aggregate amount of $*.

“OPKO Health” has the meaning set forth in the first paragraph of this
Agreement.

“Ordinary Course” means the ordinary course of business of the Business
consistent with the past practice of the Sellers.

“Other Assignment Documents” has the meaning set forth in Section 4.2(a)(iv).

“OTI” has the meaning set forth in the first paragraph of this Agreement.

“OTI UK” has the meaning set forth in the first paragraph of this Agreement.

“Permitted Encumbrances” means any minor imperfections of title or similar
Encumbrance that do not, and would not reasonably be expected to, individually
or in the aggregate, impair the value or interfere with the use of, the
Purchased Assets.

“Person” means any individual, corporation, partnership, limited liability
company, joint venture, trust, business association, organization, Governmental
Entity or other entity.

 

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“Potential Successor Tax” shall mean any Taxes owed by the Sellers as of the
Closing Date with respect to which the Buyer may have successor liability.

“Product Regulatory Documents” means (a) any approvals, consents, licenses,
permits, waivers, applications, registrations or other authorizations relating
to the ownership or operation of the Purchased Assets including the Products,
whether with the FDA or any other similar regulatory agencies in other
countries, or the conduct of the Business and (b) all supplements and amendments
that may be filed with respect to any filings described in the preceding clause
(a).

“Product Technical Information” means the following information owned by or
controlled by the Sellers, as in existence and in the possession of the Sellers
as of the Closing Date relating to the Products and the Business: Product
specifications and test methods, drawings, designs, technical information,
regulatory and clinical trial materials, data and information, manufacturing and
packaging instructions, records of complaints, and other documents necessary for
the manufacture, control and release of the Products as presently conducted by,
or on behalf of, the Sellers or any of their Affiliates.

“Products” means the OPKO Spectral OCT SLO; the development stage OCT devices
(Falcon 1 and 2); and the A, B, and UBM ultrasound devices on the OTIS-Scan
3000.

“Purchase Orders” has the meaning set forth in Section 2.1(a)(vi).

“Purchase Price” has the meaning set forth in Section 3.2(b).

“Purchased Assets” has the meaning set forth in Section 2.1(a).

“Recommendation” has the meaning set forth in Section 8.2.

“Regulations” means the Transfer of Undertakings (Protection of Employment)
Regulations 2006.

“Requisite Shareholder Vote” has the meaning set forth in Section 8.2.

“Restricted Area” has the meaning set forth in Section 7.7(d)(i).

“Restricted Period” means the period ending on the earlier of (i) the fifth
anniversary of the Closing Date and (ii) the date on which the Royalty ceases to
be payable under the terms of this Agreement.

“Royalty” has the meaning set forth in Section 3.2(b).

“Royalty Payment Date” has the meaning set forth in Section 3.2(a).

“Royalty Period” has the meaning set forth in Section 3.2(b).

“Seller Indemnified Parties” has the meaning set forth in Section 11.3.

“Seller(s)” has the meaning set forth in the first paragraph of this Agreement.

 

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“Tax(es)” means all federal, state, local and foreign taxes, customs, duties,
governmental fees and assessments, whether of the United States, Canada, the
United Kingdom or elsewhere, including all interest, penalties and additions
with respect thereto, and any obligation to pay any amount in respect of Tax or
other amounts as set out above.

“Tax Return” means any report, return, election, notice, estimate, declaration,
information statement and other forms and documents (including all schedules,
exhibits and other attachments thereto) relating to and filed or required to be
filed with a taxing authority in connection with any Taxes (including estimated
Taxes).

“Third-Party Claim” has the meaning set forth in Section 11.4(b).

“Transaction Documents” means the instruments and documents described in
Section 4.2 of this Agreement, which are to be executed and delivered by or on
behalf of the Buyer and the Sellers.

“Transferring Employees” shall mean those employees of the Sellers who are
wholly or mainly assigned to work in the Business in the UK and whose names are
listed in Section 8.4.

“Transitional Services Agreement” means a transitional services agreement to be
executed and delivered by the Buyer, the Company and the Sellers substantially
in the form set forth on Attachment B and initialed by the parties for the
purposes of identification.

“UK Assets” has the meaning set forth in Section 2.4.

“VATA 1994” has the meaning set forth in Section 2.4(b).

“VAT Records” means the records required to be kept by a taxable person in
accordance with regulation 31 of the Value Added Tax Regulations 1995/2518.

ARTICLE II.

SALE AND PURCHASE OF PURCHASED ASSETS

SECTION 2.1. Purchase and Sale.

(a) Except for the Excluded Assets, upon the terms and subject to the conditions
of this Agreement and in consideration for the Purchase Price, the Sellers will
sell, assign, transfer, convey and deliver to the Buyer, free and clear from all
Encumbrances other than Permitted Encumbrances, and the Buyer will purchase,
acquire and accept, on the Closing Date, all of the right, title and interest of
the Sellers in and to the assets, properties and rights of every kind and
nature, whether real, personal or mixed, tangible or intangible (including
goodwill), wherever located that relate to, or are used or held for use by the
Business (collectively, the “Purchased Assets”), including, without limitation,
the following:

 

  (i) any assets of the Business to the extent specifically included in the
Balance Sheet (other than Accounts Receivables for which payment is received for
Inventory which is sold prior to the Closing Date in the Ordinary Course) and
any assets acquired or created by, or in respect of, the Business following the
Balance Sheet Date;

 

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  (ii) all of the Sellers’ right, title and interest in and to the Intellectual
Property owned or controlled by the Sellers relating to the Business including
without limitation those set forth in Schedule 2.1(a)(ii);

 

  (iii) all Product Regulatory Documents including without limitation those set
forth in Schedule 2.1(a)(iii), to the extent transferable or assignable to the
Buyer;

 

  (iv) all Accounts Receivables as at the Closing Date, and any claim, remedy or
other right related to any of the foregoing;

 

  (v) the Product Technical Information;

 

  (vi) all outstanding customer purchase orders for the Products (the “Purchase
Orders”);

 

  (vii) all rights of the Sellers under the Contracts;

 

  (viii) the Leased Real Property;

 

  (ix) all deposits, advances, prepaid expenses and other prepaid items relating
to, or arising from the Business;

 

  (x) books and records relating to the Business, including, but not limited to,
(i) all books of account, financial and accounting records, inventory books and
records, customer lists, price lists, distributor lists, sales material and
records, customer purchasing histories, supplier lists, production data, quality
control records and procedures, customer complaints and inquiry files, research,
development and manufacturing files, records and data (including correspondence
with Governmental Entities), and (ii) all information or documents relating to
the Hired Employees and the Transferring Employees, but excluding the VAT
Records (collectively, “Books and Records”);

 

  (xi) all equipment and other tangible property, owned, leased or held for use
in connection with the Business, including fixtures, equipment, machinery,
tools, office equipment, telecopiers, supplies, computers and any other physical
or depreciable assets owned, leased or used in connection with the Business as
set forth on Schedule 2.1(a)(xi) (collectively, “Equipment”);

 

  (xii) the Sellers’ existing inventories of the Products (including raw
materials, spare parts, works-in-progress, components, supplies, and finished
product) (the “Inventory”);

 

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  (xiii) all goodwill incident to, and the going concern value of, the Business;

 

  (xiv) all advertising, marketing and other promotional materials used in
connection with the Business;

 

  (xv) all rights to causes of action, lawsuits, judgments, claims and demands
of any nature whatsoever available or being pursued by the Sellers, whether
arising by way of counterclaim or otherwise, arising out of or as and to the
extent relating to the Business, other than as and to the extent relating to any
Excluded Assets or Excluded Liabilities; and

 

  (xvi) all rights in and under all express or implied guarantees, warranties,
representations, covenants, indemnities and similar rights in favour of any
Seller arising out of or as and to the extent relating to the Business, other
than any such rights as and to the extent relating to any Excluded Assets or
Excluded Liabilities.

(b) In the event any Accounts Receivables properly payable to the Buyer are paid
to the Sellers by a debtor on or after the Closing Date, the Sellers shall
receive the same as trustee for the Buyer and shall pay the same to the Buyer as
soon as is reasonably practicable. Furthermore, the Sellers shall (at the cost
of the Buyer) afford to the Buyer such assistance as the Buyer may reasonably
require to recover the Accounts Receivables outstanding at Closing and shall
pass on any trade enquiries relating to the Business which the Sellers receive.

(c) The Buyer acknowledges and agrees that the Sellers may, subject to the
provisions of this Section 2.1(c), retain solely for purposes of complying with
applicable law and for legal and regulatory purposes as a seller of medical
instrumentation products, one or more copies of all or any part of the
documentation that the Sellers deliver to the Buyer pursuant to Section 2.1. The
copies will be retained by the Sellers’ legal counsel and the Sellers agree to
treat such copies as confidential information in accordance with the provisions
of Section 7.7(a).

SECTION 2.2. Excluded Assets.

Notwithstanding the foregoing, the Purchased Assets shall not include the
following assets (collectively, the “Excluded Assets”):

(a) the Sellers’ corporate seals, organizational documents, minute books, stock
books, Tax Returns, general ledger and other records having to do with the
corporate organization of the Sellers (the “Excluded Books and Records”);

(b) all right, title and interest in and to the equity interests or capital
stock of any of the Sellers and OPKO Health;

(c) cash and cash equivalents;

(d) assets held by the Sellers which do not relate exclusively to the Business
or the Products being those assets listed on Schedule 2.2(d);

 

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(e) employment and other records required by law to be maintained by the Sellers
including the VAT Records, provided that in such case, the Sellers shall provide
copies of any such records which relate to the Business to the Buyer upon the
request of the Buyer;

(f) Employee Benefit Plans for the Sellers’ employees;

(g) rights in and to the Sellers’ website and domain names, trademarks, service
marks, trade dress, logos, trade names, and corporate names not specifically
included on Schedule 2.1(a)(ii), together with all translations, adaptations,
derivations, and combinations, applications, registrations, and renewals
relating thereto;

(h) all of Sellers’ rights and interests under the Excluded Contracts; and

(i) all of the Sellers’ rights and interests under * Purchase Orders and the *
Invoices.

SECTION 2.3. Assumption of Liabilities and Obligations.

(a) Assumed Liabilities. Except for Excluded Liabilities, the Sellers will on
the Closing Date, sell, assign, transfer, convey and deliver to the Buyer and
the Buyer will assume, be responsible for and pay, perform and/or otherwise
discharge when due all Liabilities that arise out of, or are related to, the
Purchased Assets and the Business, including without limitation, warranty and
service obligations for all Products, irrespective of whether such Products were
sold prior to or following the Closing Date (collectively, the “Assumed
Liabilities”).

(b) Excluded Liabilities. Notwithstanding the foregoing, the Buyer shall not
assume or be responsible for any Liabilities of the Sellers or their Affiliates
set forth below (the “Excluded Liabilities”):

 

  (i) any Liabilities arising out of or relating to the fees, costs and expenses
of the Sellers or their Affiliates incurred, or for which the Sellers or their
Affiliates will be liable, in connection with the transactions contemplated by
this Agreement and the other Transaction Documents, including all professional,
accounting and consulting fees;

 

  (ii) any Liabilities under or with respect to any Seller Employee Benefit
Plan;

 

  (iii) any Liability related to employment of any employee of the Sellers prior
to, on or after the Closing Date, except (subject to (ix) below) with respect to
Hired Employees on and after the Hire Date PROVIDED THAT this
Section 2.3(b)(iii) does not apply to the Transferring Employees - the
provisions of Appendix 1 will apply to them;

 

  (iv) any Liability related to an Excluded Asset;

 

  (v)

any Liability arising out of or relating to any Tax of any Seller including but
not limited to any Potential Successor Tax, including without limitation any
Liability for any of such Taxes resulting from the transactions contemplated
hereby or by the Transaction Documents (other

 

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  than any Taxes that are the responsibility of the Buyer pursuant to
Section 2.4) and any Liability for any costs, fees or expenses incurred in
preparing any return, or otherwise in dealing with any compliance obligation, in
relation to any such Taxes;

 

  (vi) any Liability in respect of, or relating to, professional fees due to *
relating to the acquisition of OTI by OPKO Health in November 2007;

 

  (vii) any Liability in respect of, or relating to, the breaches of service
obligations to Nidek Co. Ltd. (“Nidek”) under the services agreement between
OTI, Nidek and Newport Corporation dated 29 December 2006 or otherwise under
that agreement;

 

  (viii) any Liability arising out of or relating to the Excluded Contracts;

 

  (ix) any Liability arising out of, or relating to, the * Purchase Orders; or

 

  (x) any Liability arising out of, or relating to, any action, claim, suit or
proceeding against the Business that is commenced or, to the Sellers’ Knowledge,
threatened as of the Closing Date.

(c) The Company hereby unconditionally guarantees the full and prompt payment
and performance of all of the Buyer’s obligations hereunder, including without
limitation the assumption of all the Assumed Liabilities.

SECTION 2.4. Transfer Taxes.

All transfer, sales, value added, stamp duty and similar Taxes payable in
respect of the sale of the Purchased Assets under this Agreement will be paid by
the Buyer. The following provisions shall apply with respect to any of the
Purchased Assets the supply of which would, but for the provisions of article 5
of the Value Added Tax (Special Provisions) Order 1995, constitute a supply of
goods or services where the place of supply is the United Kingdom (“UK Assets”):

(a) The Sellers and the Buyer intend that article 5 of the Value Added Tax
(Special Provisions) Order 1995 shall apply to the sale of the UK Assets under
this Agreement and agree to use all reasonable endeavours to secure that the
sale is treated as neither a supply of goods nor a supply of services under that
article.

(b) The Sellers warrant that each relevant Seller in respect of UK Assets is a
taxable person for the purposes of section 3 of the Value Added Tax Act 1994
(“VATA 1994”), and is using the UK Assets to carry on a business as a going
concern.

(c) The Sellers warrant that neither they, nor any relevant associate as that
term is defined in paragraph 3 of Schedule 10 to VATA 1994, have opted to tax
any Leased Real Property situated in the UK under paragraph 2 of Schedule 10 to
VATA 1994 or made a real estate election under paragraph 21 of Schedule 10 to
VATA 1994.

 

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(d) If, nevertheless, any VAT is payable on the sale of UK Assets under this
Agreement and HM Revenue & Customs has so confirmed in writing after full
disclosure of all material facts, the relevant Sellers shall promptly deliver to
the Buyer a proper VAT invoice in respect of the VAT payable. Following receipt
of the VAT invoice, the Buyer shall pay the relevant Sellers the amount of that
VAT within five business days.

(e) Before sending any relevant letter to HM Revenue & Customs, the relevant
Sellers shall give the Buyer a reasonable opportunity to comment on it, and
shall make such amendments as the Buyer reasonably requires.

(f) The relevant Sellers shall, on request, make available any information and
documents in their control required to establish to HM Revenue & Customs and any
tribunal or court that no liability, or a reduced liability, arises on the Buyer
or any other company under section 44 of VATA 1994 as a result of the sale of
the UK Assets.

(g) The Sellers and the Buyer intend that section 49 of VATA 1994 shall apply to
the sale of the UK Assets under this Agreement but they do not intend to make a
joint application to HM Revenue & Customs for the Buyer to be registered for VAT
under the VAT registration number of the relevant Sellers, pursuant to
Regulation 6(1)(d) of the VAT Regulations 1995.

(h) If the Buyer pays a Seller an amount in respect of VAT under Section 2.4(b)
and HM Revenue & Customs notes that all or part of it was not properly
chargeable, the relevant Seller shall repay the amount or relevant part of it to
the Buyer. The relevant Seller shall make the repayment promptly after the
ruling, unless it has already accounted to HM Revenue & Customs for the VAT.

(i) The Sellers shall retain their VAT Records for the period required by law
and shall give the Buyer access to such records as reasonably required under the
terms of section 49(5) of VATA 1994.

ARTICLE III.

PURCHASE PRICE

SECTION 3.1. Purchase Price.

In exchange for the Purchased Assets, the Buyer will pay and deliver to the
Sellers at Closing an aggregate of US$17.5 million, to be paid in immediately
available funds to an account designated by the Sellers (the “Cash
Consideration”).

SECTION 3.2. Royalty.

(a) Royalty on Sales. As additional consideration for the sale and transfer of
the Purchased Assets from the Sellers to the Buyer, and subject to
Section 3.2(b), the Buyer hereby agrees to pay to the Sellers within forty five
days of the end of each calendar quarter during the Royalty Period (the “Royalty
Payment Date”):

 

  (i) a royalty of five percent (5%) on Net Sales of Products sold by the
Company, the Buyer, their Affiliates, sublicensees, or distributors; and

 

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  (ii) a royalty of two and one half percent (2.5%) on Net Sales of the Company
Products sold by the Company, the Buyer, their Affiliates, sublicensees or
distributors.

(b) Royalty Term. The royalty obligation set forth in Section 3.2(a) above (the
“Royalty”) shall commence on the second anniversary of the Closing and terminate
upon the date on which cumulative royalties actually paid to the Sellers
pursuant to this Agreement reach an aggregate of US$22.5 million (the “Royalty
Period”). For clarity the Buyer and the Sellers acknowledge and agree that no
royalty shall accrue, be paid or payable based on sales occurring between the
Closing Date and the second anniversary of Closing. The Cash Consideration and
the Royalty are hereinafter collectively referred to as the “Purchase Price”.
Nothing shall oblige the Buyer to pay to the Sellers a sum greater than US$22.5
million under this Section 3.2.

(c) Withholding. To the extent any Royalty payable pursuant to Section 3.2(a) is
paid to the Sellers by the Buyer, the Buyer shall not withhold Taxes on such
Royalty payments except as required by law.

(d) Royalty Reporting. A statement showing how any amounts payable to the
Sellers under Section 3.2(a) have been calculated shall be submitted to the
Sellers during the Royalty Period on the Royalty Payment Date whether or not any
Royalties are earned and due on such Royalty Payment Date.

SECTION 3.3. Transfer of Purchased Assets.

(a) One hundred percent (100%) of the Purchase Price shall be allocated to the
assets of Instrumentation, which owns all of the Purchased Assets being
conveyed. The parties acknowledge that the Buyer may after Closing transfer some
of the Purchased Assets, in particular, the Intellectual Property, to the
Company and nothing in this Agreement shall prejudice the Buyer’s ability to do
this nor the consideration which the Buyer and the Company decide is properly
payable in connection therewith.

ARTICLE IV.

THE CLOSING

SECTION 4.1. Closing Date.

The closing of the sale and transfer of Purchased Assets (the “Closing”) will
take place at the offices of the Sellers, or at another place designated by the
parties, on the first Business Day following the date on which all of the
relevant conditions to each party’s obligations under this Agreement have been
satisfied or waived, or at such other time, date and/or place as mutually agreed
to by the parties hereto (such date being referred to herein as the “Closing
Date”).

SECTION 4.2. Transactions to Be Effected at Closing.

(a) The Sellers will deliver or cause to be delivered to the Buyer each of the
following items, in each case appropriately executed:

 

  (i) this Agreement;

 

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  (ii) the Bill of Sale and Assignment and Assumption Agreement;

 

  (iii) the Transitional Services Agreement;

 

  (iv) the Lease Extension Agreement; and

 

  (v) such other duly executed instruments of sale, transfer, conveyance and
assignment and assumption as the Buyer may reasonably request (“Other Assignment
Documents”).

(b) The Buyer will deliver or cause to be delivered to the Sellers each of the
following items, in each case appropriately executed:

 

  (i) this Agreement;

 

  (ii) the Cash Consideration;

 

  (iii) the Bill of Sale and Assignment and Assumption Agreement;

 

  (iv) the Transitional Services Agreement; and

 

  (v) the Lease Extension Agreement.

ARTICLE V.

REPRESENTATIONS AND WARRANTIES OF SELLERS

The Sellers hereby jointly and severally represent and warrant to the Buyer and
the Company as of the date hereof and on Closing as set out in this Article V.

SECTION 5.1. Seller Organization; Good Standing.

Instrumentation is a limited liability company, duly organized, validly existing
and in good standing under the laws of the State of Delaware. OTI is a
corporation duly organized, validly existing and in good standing under the laws
of Ontario. OPKO Health is a corporation duly organized, validly existing and in
good standing under the laws of the State of Delaware. OTI UK is a private
limited company duly organized, validly existing and in good standing under the
laws of England and Wales. Each Seller has the requisite power and authority to
own the Purchased Assets and to carry on its business as currently conducted.

SECTION 5.2. Authority; Execution and Delivery.

Each Seller has the requisite corporate power and authority to enter into this
Agreement and the Transaction Documents and to consummate the transactions
contemplated hereby. The execution and delivery of this Agreement and the
Transaction Documents by the Sellers and the consummation of the transactions
contemplated hereby have been duly and validly authorized. This Agreement and
the Transaction Documents have been duly executed and delivered by the Sellers
and, assuming the due authorization, execution and delivery of this Agreement
and the Transaction Documents by the Buyer, will constitute the legal, valid and
binding obligation of

 

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the Sellers, enforceable against them in accordance with their terms, subject to
applicable bankruptcy, insolvency, reorganization, moratorium, fraudulent
transfer and other similar laws affecting creditors’ rights generally from time
to time in effect and to general principles of equity (including concepts of
materiality, reasonableness, good faith and fair dealing), regardless of whether
considered in a proceeding in equity or at law.

SECTION 5.3. Consents; No Violation, Etc.

The execution and delivery of this Agreement and the Transaction Documents do
not, and the consummation of the transactions contemplated hereby and the
compliance with the terms hereof will not, (i) violate any Governmental Rule
applicable to the Sellers, (ii) conflict with any provision of the certificate
of incorporation, articles or organization or by-laws (or similar organizational
document) of the Sellers, (iii) conflict with any Contract to which the Sellers
are a party or by which they are otherwise bound, including any Contract related
to any of the Products, or (iv) require any approval, authorization, consent,
license, exemption, filing or registration with any court, arbitrator or
Governmental Entity, except, with respect to the foregoing clauses (i) and
(iii), for such violations or conflicts which would not result in a Material
Adverse Change or materially interfere with the Sellers’ performance of their
obligations hereunder or, with respect to the foregoing clause (iv), for such
approvals, authorizations, consents, licenses, exemptions, filings or
registrations which have been obtained or made or which, if not obtained or
made, would not result in a Material Adverse Change or materially interfere with
the Sellers’ performance of its obligations hereunder.

SECTION 5.4. Title to Purchased Assets.

(a) The Sellers have good and transferable title or a valid leasehold interest
in all of the Purchased Assets free and clear of all Encumbrances, other than
Permitted Encumbrances. At Closing, the Sellers will transfer to the Buyer good
and valid title to all of the Purchased Assets owned by them and, with respect
to the Leased Real Property and other assets leased by the Sellers, the Sellers
shall assign to the Buyer good and valid leasehold interests in such Leased Real
Property, in each case free and clear of any and all Encumbrances other than
Permitted Encumbrances.

(b) Except as Disclosed, the Purchased Assets constitute all of the assets and
properties considered by the Sellers to be necessary and sufficient to conduct
the Business in all material respects as it is currently conducted.

(c) The rents payable in respect of the Leased Real Properties have been duly
paid and the covenants and conditions in respect thereof have been duly
performed and observed in all material respects and none of the Sellers have
received any written notice of, nor to Sellers’ Knowledge are there any
circumstances giving rise to, any right of termination of any lease of the
Leased Real Properties prior to the normal expiry thereof. There are no
outstanding claims or disputes at the instance of Sellers or the landlords under
any lease for the Leased Real Properties.

 

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SECTION 5.5. Financial Statements and Balance Sheet.

(a) The Balance Sheet is complete and correct in all material respects, fairly
presents in all material respects the financial condition of the Business as at
the Balance Sheet Date and has been prepared in accordance with GAAP (subject to
normal adjustments) and in conformity with the practices consistently applied by
the Sellers without modification of the accounting principles used in the
preparation thereof as at the date indicated.

(b) The Financial Statements have been prepared in accordance with International
Financial Reporting Standards (“IFRS”) from the books and records of the
Sellers. The balance sheets included in the Financial Statements (including the
related notes and schedules) fairly present in all material respects the
consolidated financial position of the Business as of the date of such balance
sheets, and the statements of income and cash flows included in the Financial
Statements (including any related notes and schedules) fairly present in all
material respects the consolidated results of operations and changes in cash
flows, as the case may be, of the Business for the periods set forth therein, in
each case in accordance with IFRS.

(c) There has been no change in any accounting policy, practice or procedure of
the Sellers in the past three (3) years, except as required by applicable law or
in accordance with GAAP.

(d) The Sellers maintain a system of internal controls over financial reporting
which provides reasonable assurance regarding the reliability of their financial
reporting and preparation of financial statements in accordance with GAAP.

SECTION 5.6. Absence of Certain Changes.

(a) Except as Disclosed, since December 31, 2010, the Sellers have conducted the
Business only in the Ordinary Course or as contemplated by this Agreement and
there has not been any Material Adverse Change or any change, event or
development that, individually or in the aggregate, would reasonably be expected
to have a Material Adverse Change.

(b) Except as Disclosed, since December 31, 2010, each Seller has in respect of
the Business:

 

  (i) not engaged in any new line of business or made any commitment with
respect to the Business or the Purchased Assets except those in the Ordinary
Course;

 

  (ii) duly and timely filed or cause to be filed all (i) reports required to be
filed with any Governmental Entity, agency or authority and (ii) Tax Returns
required to be filed with any Governmental Entity, agency or authority and
promptly paid or caused to be paid when due all Taxes, assessments and
governmental charges, including interest and penalties levied or assessed,
unless diligently contested in good faith or an extension has been granted by
appropriate proceedings;

 

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  (iii) paid or caused to be paid when due all Potential Successor Taxes,
including interest and penalties levied or assessed;

 

  (iv) not disposed of or permitted to lapse any right to the use of any of the
Intellectual Property material to the conduct of the Business;

 

  (v) not (i) sold any Purchased Asset, other than Inventory and finished and
unfinished goods sold in the Ordinary Course; (ii) created, incurred or assumed
any indebtedness secured by the Purchased Assets other than in the Ordinary
Course; (iii) granted, created, incurred or suffered to exist any Encumbrance
other than a Permitted Encumbrance on the Purchased Assets; (iv) incurred any
liability or obligation (absolute, accrued or contingent) that would be an
Assumed Liability except in the Ordinary Course; (v) written-off any guaranteed
check, note or account receivable except in the Ordinary Course or unless in
accordance with GAAP; (vi) written-down the value of any asset or investment
(including any Purchased Asset) on the books and records of the Sellers, except
(A) for depreciation and amortization in the Ordinary Course or (B) in
accordance with GAAP; or (vii) cancelled any debt or waived any claim or right
under any Contract that would be material to the operation of the Business
except in the Ordinary Course;

 

  (vi) not increased in any manner the base compensation of, accelerated the
payment of any base compensation or bonus owed to, or entered into any new bonus
or incentive agreement or arrangement with, any of its employees, independent
contractors, officers, directors or consultants;

 

  (vii) maintained in existing condition and repair (ordinary wear and tear
excepted), consistent with past practices and the Sellers’ obligations as
tenants under the Leases, all buildings, offices, shops and other structures
occupied by the Sellers and located on the Leased Real Property;

 

  (viii) maintained suppliers and Inventory at levels that are consistent with
the Ordinary Course;

 

  (ix) performed in all material respects all of its obligations under all
Contracts, and not materially defaulted or suffered to exist any event or
condition that with notice or lapse of time or both is reasonably likely to
constitute a material default under any Contract (except those being contested
in good faith) and not entered into, assumed or amended any material Contract;

 

  (x) maintained in full force and effect policies of insurance comparable in
amount and scope of coverage to that maintained in prior periods;

 

  (xi) continued to collect accounts receivable and pay trade accounts payable
in the Ordinary Course and continued its billing practices in the Ordinary
Course; and

 

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  (xii) not authorized, or committed or agreed to take, any of the prohibited
actions in the foregoing clauses (i) through (xi).

SECTION 5.7. Litigation.

(a) Except as Disclosed, there is no suit, claim, action, investigation,
arbitration or proceeding pending or, to the Knowledge of the Sellers,
threatened against, relating to or involving any Seller, the Business or the
Purchased Assets before any Governmental Entity or arbitrator. The Sellers are
not subject to any judgment, decree, injunction, ruling or order of any court or
arbitration panel naming the Sellers or the Purchased Assets.

SECTION 5.8. Legal and Regulatory Issues.

Except as Disclosed, since January 1, 2008, with respect to the Products, the
Sellers have not received any warning letters or other written correspondence
from the FDA or other similar regulatory bodies concerning the Products and
there has not been a recall or market withdrawal of any Product by the Sellers,
whether voluntary or involuntary nor do the Sellers have Knowledge of any such
regulatory issues which may have occurred since January 1, 2008. The Sellers do
not have any Knowledge of any regulatory issues which may have occurred within
the last five years but prior to January 1, 2008, except for any such regulatory
issues as shall not have had, and would not reasonably be expected to result in,
a Material Adverse Change.

SECTION 5.9. Compliance with Applicable Laws.

Except as Disclosed, the Sellers are and have been at all times since January 1,
2008 in compliance with all laws and Governmental Rules that are material to the
operation of the Business and applicable to them or the operation of the
Business or the ownership (as applicable) or use of the Purchased Assets and the
Leased Real Property. Except as Disclosed, since January 1, 2008, no Seller has
received written notice from any Governmental Entity of, and the Sellers have no
Knowledge of, any failure by the Sellers or the Business to comply with any
Governmental Rules that are material to the operation of the Business. The
Sellers do not have any Knowledge of any failure to comply with any Governmental
Rules within the last five years but prior to January 1, 2008, except for any
such failure as shall not have had, and would not reasonably be expected to
result in, a Material Adverse Change.

SECTION 5.10. Tax Matters.

Taxes. (i) The Sellers have complied in all material respects with all laws
relating to Taxes; (ii) all Tax Returns of the Sellers on which are required to
be reported Potential Successor Taxes and which are due to have been filed
through the date hereof (taking into account applicable extensions) in
accordance with any applicable laws have been duly filed and are true, correct
and complete in all material respects; (iii) all Potential Successor Taxes due
and owing by the Sellers (whether or not shown on any Tax Return) have been paid
in full; (iv) all deficiencies in Potential Successor Taxes asserted as a result
of any examination of any Tax Return have been paid in full, accrued on the
books of the Sellers, or finally settled; (v) no claims have been asserted and
no proposals or deficiencies for any Potential Successor Taxes are being
asserted, proposed or threatened, in writing; (vi) no claim has ever been made
against any Seller

 

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by any Governmental Entity in a jurisdiction where such Seller does not file Tax
Returns on which are required to be reported Potential Successor Taxes, and
where it has not paid Potential Successor Taxes, that such Seller is or may be
subject to taxation with respect to Potential Successor Taxes; (vii) the Sellers
have withheld and paid all material Potential Successor Taxes required to have
been paid by the Sellers in connection with amounts paid or owing to any
employee, independent contractor, creditor, stockholder or other third party;
(viii) there are no outstanding waivers or agreements by any Seller for the
extension of time for the assessment of any material Potential Successor Taxes
or deficiency thereof; and (ix) there are no liens for Taxes on the Purchased
Assets other than liens for Taxes which are not yet due and payable, nor are
there any such liens which are pending or threatened.

SECTION 5.11. Real Property.

(a) The Sellers do not own any real property.

(b) Schedule 5.11(b) sets forth the address and legal description of each parcel
of leased real property leased in connection with the Business (the “Leased Real
Property”). The Sellers have delivered, or made available, to the Buyer a true
and complete copy of each lease agreement for the Leased Real Property (the
“Leases”). Each Lease is in full force and effect and constitutes a legal, valid
and binding obligation of the respective parties thereto and will continue to be
a legal, valid and binding obligation of the respective parties thereto
following the Closing. With respect to each Lease and except as Disclosed,
(i) neither the Sellers nor, to the Knowledge of the Sellers, any other party to
any Lease is in breach or in default thereunder, and no event has occurred
which, with notice or lapse of time (or both), would constitute such a breach or
default thereunder, (ii) to the Knowledge of the Sellers, no other party to the
Lease has repudiated, or threatened to repudiate, any provision thereof; and
(iii) no consent of the landlords under any such lease or sublease is required
as a result of the consummation of the transactions contemplated hereby.

SECTION 5.12. Intellectual Property.

(a) Schedule 2.1(a)(ii) identifies a true and complete list of (i) all of the
material Intellectual Property owned or controlled by the Sellers and used in
connection with the Business and (ii) all material license agreements and
arrangements with respect to any of such Intellectual Property to which the
Sellers are a party, whether as licensee, licensor or otherwise (other than
non-exclusive end-user licenses for commercially available prepackaged computer
software generally available to the public). The Sellers own and have good and
exclusive title to, or have licenses (sufficient for the conduct of the Business
as currently conducted) to, each item of Intellectual Property necessary for the
operation of the Business, free and clear of all Encumbrances. Each item of
Intellectual Property owned or used by the Sellers immediately prior to the
Closing will be owned or available for use by the Buyer on substantially similar
terms and conditions immediately after the Closing. Any and all registration,
maintenance and/or renewal fees for any registered Intellectual Property listed
in Schedule 2.1(a)(ii), due on or before Closing have been, or will be, paid in
full prior to Closing.

(b) To the extent that any Intellectual Property has been developed or created
by a third party for the Sellers or their Affiliates and is material to the
operations of the Business as

 

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currently conducted, to the Knowledge of the Sellers, the Sellers (i) have
obtained ownership of and are the exclusive owners of, or (ii) have obtained a
license (sufficient for the conduct of the Business as currently conducted and
as proposed to be conducted) to all of such third party’s Intellectual Property
in such work, material or invention by operation of law or by valid assignment.

(c) To the Knowledge of the Sellers, Know How which is material to the Business
as presently conducted has been documented or is otherwise within the knowledge
of the employees identified on Schedule 5.14 to this Agreement.

(d) To the Sellers’ Knowledge, any and all Confidential Information and Know How
has been kept secret and confidential and has not been disclosed to any third
parties except under a valid and enforceable obligation of confidentiality.

(e) To the Knowledge of the Sellers, the operation of the Business as it is
currently conducted, including the Sellers’ design, development, marketing and
sale of the products or services of the Business (including with respect to
products currently under development), does not infringe or misappropriate in
any manner the Intellectual Property of any third party or, to the Knowledge of
the Sellers, constitute unfair competition or trade practices under the laws of
any jurisdiction.

(f) The Sellers have not received written notice from any third party, that the
operation of the Business as it is currently conducted, or any act, product or
service of the Business, materially infringes or misappropriates the
Intellectual Property of any third party or constitutes unfair competition or
trade practices under the laws of any jurisdiction in which the Business is
currently conducted by the Sellers.

(g) To the Knowledge of the Sellers, no other Person has interfered with,
infringed upon, misappropriated, or otherwise come into conflict with any
Intellectual Property rights of the Sellers. There are no pending or, to the
Knowledge of the Sellers, threatened claims against the Sellers or their
employees or independent contractors alleging that the Sellers’ Intellectual
Property infringes on or conflicts with the rights of any other Person.

SECTION 5.13. Contracts.

(a) Schedule 5.13 lists all Contracts to which the Sellers are a party and which
are material to the Business or the Purchased Assets. The Sellers have
delivered, or made available, to the Buyer a true, correct and complete copy of
each contract or other agreement (as amended to date) listed in Schedule 5.13
(or a summary thereof in the case of an oral contract).

(b) Except as Disclosed, there are no Contracts that are material to the
Business or the Purchased Assets and that are unlikely to have been fully
performed in accordance with their terms within one year after the date each was
entered into, are non-arm’s length, and/or contain exclusivity undertakings in
favour of the counterparty.

(c) The Sellers have not committed any material breach of, or material default
under or repudiated, the terms of any Contract set forth in Schedule 5.13. To
the Knowledge of the Sellers, no counterparty to any Contract set forth in
Schedule 5.13 is in breach thereof, and no

 

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event has occurred which, with notice or lapse of time (or both), would
constitute a breach by any counterparty under any such Contract, nor has any
counterparty repudiated, terminated or, to the Knowledge of the Sellers,
threatened to repudiate or terminate any provision under any such Contract.

(d) Each Contract is a legal, valid and binding obligation of the Sellers,
enforceable against the Sellers in accordance with its terms (except as limited
by applicable bankruptcy, insolvency, reorganization, moratorium or other
similar laws now or hereafter in effect relating to or affecting creditors’
rights generally, and subject to the limitations imposed by general equitable
principles, regardless of whether such enforceability is considered in a
proceeding at law or in equity).

SECTION 5.14. Employees.

(a) Schedule 5.14(a) is an accurate list of all current employees and
independent contractors of the Sellers involved in the Business and their hourly
rates of compensation, base salaries or other form of direct base compensation
(as applicable). Schedule 5.14(a) also sets forth with respect to each employee
of the Business their entitlement to any bonus or commission payments, the
number of stock options which have been awarded to such employees, and their
location of employment. The Sellers have complied in all material respects with
all applicable laws relating to the hiring of employees and the employment of
labor, including provisions thereof relating to immigration and citizenship,
wages, hours, pay equity, equal opportunity, collective bargaining and the
payment and withholding of social security and other Taxes. The Sellers have no
Knowledge of any material labor relations problems (including, without
limitation, any union organization activities, threatened or actual strikes or
work stoppages or material grievances).

(b) Except as Disclosed, (i) the Sellers are not delinquent in payments to any
of their respective employees or independent contractors for any wages,
salaries, commissions, bonuses or other direct compensation for any services
performed by them to date or amounts required to be reimbursed to such employees
or independent contractors, (ii) there is no unfair labor practice complaint
against the Sellers pending before the National Labor Relations Board or any
other Governmental Entity, or, to the Knowledge of the Sellers, threatened
against the Sellers, (iii) there is no labor strike, material dispute, slowdown
or stoppage actually pending or, to the Knowledge of the Sellers, threatened
against or involving the Sellers, (iv) no labor union currently represents or
has represented the employees of the Sellers, (v) to the Knowledge of the
Sellers, no labor union has taken any action with respect to organizing the
employees of the Sellers, and (vi) no material grievance nor any arbitration
proceeding arising out of or under collective bargaining agreements is pending
and no claim thereto has been asserted against the Sellers. The Sellers are not
a party to or bound by any collective bargaining agreement, union contract or
similar agreement.

(c) Except as Disclosed, neither the execution and delivery of this Agreement,
nor the consummation of the transactions contemplated hereby will (i) result in
any payment (including, without limitation, severance, unemployment
compensation, golden parachute, bonus or otherwise) becoming due from the
Sellers to any director or employee of the Sellers from the Sellers, under any
Employee Benefit Plan or otherwise; (ii) increase any benefits otherwise payable
by the Sellers under any Employee Benefit Plan or otherwise; or (iii) result in
the acceleration of the time of payment or vesting of any such benefits.

 

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(d) The Transferring Employees are all the employees of the Sellers in the UK
who work wholly or mainly in the Business.

(e) No offer of employment has been made to any person that has not been
accepted and remains open for acceptance as at the date of this Agreement or
that has been accepted but the employment has not yet started.

(f) The Sellers have Disclosed the full terms and conditions of employment of
the Transferring Employees and copies of all workplace policies, procedures and
staff handbooks which apply to the Transferring Employees, including a copy of
the disciplinary and grievance procedures.

(g) All contracts of the Transferring Employees can be terminated without
payment of damages or compensation (other than statutory compensation) on three
months’ notice or less given at any time.

(h) Except as Disclosed, no proposals have been made to the Transferring
Employees or any representative on their behalf (formally or informally) to
introduce, increase or otherwise vary any of the foregoing terms and conditions,
including remuneration and benefits, and the Sellers are under no contractual
obligation so to do.

(i) In respect of each of the Transferring Employees, each of the Sellers have
fully complied with its obligations under regulation 13 of the Employment
Regulations to inform and consult with trade unions or other employee
representatives on any matter concerning or arising from the transaction
undertaken by the Agreement or affecting the Transferring Employees.

(j) No Transferring Employee is receiving or is due to receive payment under any
sickness, permanent health insurance or disability schemes and there are no
pending claims for such payments.

(k) No Transferring Employee has been absent from work for 21 working days or
more in any six month period in the last three years, on account of injury,
ill-health or any other reason (other than pre-arranged holidays), whether or
not the days of absence have been consecutive.

(l) All Transferring Employees are entitled to work in the United Kingdom.

(m) The Sellers have not dismissed any employee in connection with the sale of
the Business.

SECTION 5.15. Environmental, Health, and Safety Matters.

(a) The Sellers possess all material Product Regulatory Documents, permits and
approvals required for the operation of the Business and, to the Knowledge of
the Sellers, the Sellers are in material compliance with Governmental Rules
relating to environmental, health, and safety requirements (“Environmental
Laws”), and no Liability has arisen under such Environmental Laws.

 

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(b) Since January 1, 2008, the Sellers have not received any written notice,
information request, report or other information regarding any actual or alleged
violation of Environmental Laws, or any material Liabilities, including any
investigatory, remedial or corrective obligations, relating to the Sellers or
the Leased Real Property arising under Environmental Laws. No action is pending
or, to the Knowledge of the Sellers, threatened against the Sellers alleging
violations of, or Liabilities arising under Environmental Laws.

SECTION 5.16. Affiliate Transactions.

Other than as Disclosed, no current or former officer, director, shareholder,
partner or, to the Sellers’ Knowledge, employee of the Sellers, or any of their
respective Affiliates, or any individual related by blood, marriage or adoption
to any such individual, or any entity in which any such Person or individual
owns any beneficial interest, (i) is now a party to any agreement, contract,
commitment or transaction with the Sellers (other than at-will employment
arrangements) or has any material interest in any property used by the Sellers
in connection with the Business or the Purchased Assets, (ii) is now the direct
or indirect owner of an interest in any Person that is a present or potential
competitor, supplier or customer of the Sellers or (iii) receives income from
any source which should properly accrue to the Sellers. The Sellers are not a
guarantor or otherwise liable for any actual or potential Liability, whether
direct or indirect, of any of its Affiliates.

SECTION 5.17. Liabilities.

Except as Disclosed, to the Sellers’ Knowledge, the Sellers do not have any
Liability relating to the Business, other than Liabilities reflected, reserved
against or otherwise specified in the Balance Sheet or incurred in respect of
the Business in the Ordinary Course between the Balance Sheet Date and the
Closing Date.

SECTION 5.18. Inventory.

The Inventory is merchantable and of a quality and quantity usable or saleable
in the Ordinary Course, subject to the write-downs for slow-moving and obsolete
inventory in the Ordinary Course. The inventory of the Sellers is carried on the
books and records of the Sellers in accordance with GAAP applied consistently.

SECTION 5.19. Receivables.

Except as Disclosed, all of the Accounts Receivables of the Sellers relating to
the Business represent accounts receivable that have arisen in the Ordinary
Course. Except as Disclosed, the Accounts Receivable (i) are not subject to any
valid counterclaims or setoffs other than credits, returns and allowances in the
Ordinary Course, and (ii) resulted from a bona fide sale or license to a
customer in the Ordinary Course.

 

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SECTION 5.20. No Brokers.

The Sellers have not entered into any agreement, arrangement or understanding
with any Person or firm which will result in the obligation to pay any finder’s
fee, brokerage commission or similar payment in connection with the transactions
contemplated hereby.

SECTION 5.21. Exclusive Representations and Warranties.

Other than the representations and warranties set forth in this Article V, the
Sellers are not making any other representations or warranties, express or
implied, with respect to the Products, the Purchased Assets, the Business or any
other matter, including but not limited to any warranty of merchantability or
fitness for a particular purpose or infringement of third party rights, and all
such warranties are disclaimed.

SECTION 5.22. Circular.

To the Knowledge of the Sellers, the information relating to the Business set
out in the Circular does not contain any untrue statement of a material fact or
omit to state a material fact necessary to make the statements or facts
contained therein not misleading.

ARTICLE VI.

REPRESENTATIONS AND WARRANTIES OF THE BUYER

The Buyer hereby represents and warrants to the Sellers as of the date hereof
and on Closing as follows:

SECTION 6.1. Organization; Good Standing.

Each of the Company and the Buyer is a corporation duly organized, validly
existing and in good standing under the laws of the jurisdiction of its
incorporation or organization. Each of the Company and the Buyer has all
requisite corporate power and authority to carry on its business as it is
currently being conducted. Each of the Company and the Buyer is duly qualified
to conduct business as a foreign corporation and is in good standing in every
jurisdiction where the nature of the business conducted by it makes such
qualification necessary, except where the failure to so qualify or be in good
standing would not prevent or materially delay the consummation of the
transactions contemplated hereby.

SECTION 6.2. Authority; Execution and Delivery.

Each of the Company and the Buyer has the requisite corporate power and
authority to enter into this Agreement and the Transaction Documents and to
consummate the transactions contemplated hereby. The execution and delivery of
this Agreement and the Transaction Documents by the Company and the Buyer and
the consummation of the transactions contemplated hereby have been duly and
validly authorized. This Agreement has been duly executed and delivered by the
Buyer and the Company and, assuming the due authorization, execution and
delivery of this Agreement by the Sellers, constitutes the legal, valid and
binding obligation of the Buyer and the Company, enforceable against the Buyer
and the Company in accordance with its terms, subject to applicable bankruptcy,
insolvency, reorganization,

 

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moratorium, fraudulent transfer and other similar laws affecting creditors’
rights generally from time to time in effect and to general principles of equity
(including concepts of materiality, reasonableness, good faith and fair
dealing), regardless of whether considered in a proceeding in equity or at law.

SECTION 6.3. Consents; No Violations, etc.

The execution and delivery of this Agreement do not, and the consummation of the
transactions contemplated hereby and the compliance with the terms hereof will
not, (i) violate any Governmental Rule applicable to either the Company or the
Buyer, (ii) conflict with any provision of the certificate of incorporation or
by-laws of either the Company or the Buyer, (iii) conflict with any contract to
which either the Company or the Buyer is a party or by which it is otherwise
bound or (iv) except in respect of the approval of the Circular by the UK
Listing Authority, require any approval, authorization, consent, license,
exemption, filing or registration with any court, arbitrator or Governmental
Entity, except with respect to the foregoing clauses (i) and (iii), for such
violations or conflicts which would not materially interfere with either the
Company’s or the Buyer’s performance of its obligations hereunder or result in a
Material Adverse Change to the Buyer’s or the Company’s business, with respect
to the foregoing clause (iv), for such approvals, authorizations, consents,
licenses, exemptions, filings or registrations which have been obtained or made
or which, if not obtained or made, would not materially interfere with either
the Company’s or the Buyer’s performance of its obligations hereunder or result
in a Material Adverse Change to the Buyer’s or the Company’s business.

SECTION 6.4. No Brokers.

Neither the Company nor the Buyer has entered into any agreement, arrangement or
understanding with any Person or firm which will result in the obligation to pay
any finder’s fee, brokerage commission or similar payment in connection with the
transactions contemplated hereby.

SECTION 6.5. Financing.

The Buyer will have sufficient funds to pay the Cash Consideration and all other
amounts payable by the Buyer under this Agreement at Closing.

SECTION 6.6. Exclusive Representations and Warranties.

Other than the representations and warranties set forth in this Article VI, the
Buyer is not making any other representations or warranties, express or implied
with respect to itself or the Company or any other matter whatsoever.

ARTICLE VII.

CERTAIN COVENANTS AND AGREEMENTS OF SELLERS

SECTION 7.1. Operation of Business.

(a) From and after the date of this Agreement and up until Closing, each of the
Sellers shall, except as expressly required by this Agreement and except as
otherwise consented to in advance in writing by the Buyer, which such consent
shall not be unreasonably withheld or delayed:

 

  (i) conduct the Business in the Ordinary Course and not engage in any new line
of business or make any commitment with respect to the Business or the Purchased
Assets except those in the Ordinary Course and not otherwise prohibited under
this Section 7.1;

 

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  (ii) use reasonable efforts to (i) preserve intact the goodwill and business
organization of such Seller and (ii) preserve the relationships and goodwill of
such Seller with customers, distributors, suppliers and employees of such
Seller;

 

  (iii) duly and timely file or cause to be filed all (i) reports required to be
filed with any Governmental Entity, agency or authority and (ii) Tax Returns
required to be filed with any Governmental Entity, agency or authority and
promptly pay or cause to be paid when due all Taxes, assessments and
governmental charges, including interest and penalties levied or assessed,
unless diligently contested in good faith or an extension has been granted by
appropriate proceedings;

 

  (iv) maintain in existing condition and repair (ordinary wear and tear
excepted), consistent with past practices and the Sellers’ obligations as
tenants under the Leases, all buildings, offices, shops and other structures
occupied by the Sellers and located on the Leased Real Property;

 

  (v) not dispose of or permit to lapse any right to the use of any of the
Intellectual Property material to the conduct of the Business;

 

  (vi) maintain, and not permit to lapse, each Product Regulatory Document held
by such Seller as of the date hereof material to the operation of the Business;

 

  (vii) not (i) sell any Purchased Asset, other than Inventory and finished and
unfinished goods sold in the Ordinary Course, (ii) create, incur or assume any
indebtedness secured by the Purchased Assets other than in the Ordinary Course,
(iii) grant, create, incur or suffer to exist any Encumbrance other than a
Permitted Encumbrance on the Purchased Assets, (iv) incur any liability or
obligation (absolute, accrued or contingent) that would be an Assumed Liability
except in the Ordinary Course, (v) write-off any guaranteed check, note or
account receivable except in the Ordinary Course or unless in accordance with
GAAP, (vi) write-down the value of any Purchased Asset except (A) for
depreciation and amortization in the Ordinary Course or (B) in accordance with
GAAP, (vii) cancel any debt or waive any claim or right under any Contract that
would be material to the operation of the Business except in the Ordinary
Course, or (viii) make any commitment for any capital expenditure in excess of
US$100,000;

 

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  (viii) not increase in any manner the base compensation of, accelerate the
payment of any base compensation or bonus owed to, or enter into any new bonus
or incentive agreement or arrangement with, any of its employees, independent
contractors, officers, directors or consultants, except as required by
applicable law;

 

  (ix) not enter into any collective bargaining agreement;

 

  (x) maintain supplies and Inventory at levels that are consistent with
seasonal demand and in the Ordinary Course;

 

  (xi) continue to collect accounts receivable and pay trade accounts payable in
the Ordinary Course and continue its billing practices in the Ordinary Course;

 

  (xii) perform in all material respects all of its obligations under all
Contracts, and not materially default or suffer to exist any event or condition
that with notice or lapse of time or both could constitute a material default
under any Contract (except those being contested in good faith) and not enter
into, assume or amend any material Contract;

 

  (xiii) maintain in full force and effect policies of insurance comparable in
amount and scope of coverage to that now maintained by or on behalf of the
Sellers;

 

  (xiv) continue to maintain its books and records in accordance with GAAP
consistently applied and on a basis consistent with past practice; and

 

  (xv) not authorize, or commit or agree to take, any of the prohibited actions
in the foregoing clauses (i) through (xiv).

(b) Nothing contained in this Agreement shall be construed to give to the Buyer,
directly or indirectly, rights to control or direct the Sellers’ operations
prior to the Closing. Prior to the Closing, the Sellers shall exercise,
consistent with the terms and conditions of this Agreement, complete control and
supervision of the operations of the Business.

SECTION 7.2. Full Access.

From and after the date of this Agreement and through to Closing, the Sellers
shall permit representatives of the Buyer and the Company (including legal
counsel and accountants) to have access at reasonable times upon reasonable
advance written notice, and in a manner so as not to interfere with the normal
business operations of the Sellers, to premises, properties, personnel, books,
records, contracts, and documents of or pertaining to the Business. The Buyer
and the Company will treat and hold as such any confidential information it
receives from any of the Sellers in the course of the reviews contemplated by
this Section 7.2, will not use any of the

 

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confidential information except in connection with this Agreement, and, if this
Agreement is terminated for any reason whatsoever, will return to the Sellers
(or destroy, if requested by the Sellers, and provide documentation thereof) all
tangible embodiments (and all copies) of the confidential information
(including, without limitation, all summaries, reports and analyses derived
therefrom (excluding such summaries, reports and analyses derived by the Buyer’s
or the Company’s third party consultants)) that are in its possession. The Buyer
or the Company may meet with or otherwise contact the Hired Employees and the
Transferring Employees as agreed between the Buyer and the Sellers. Other than
as previously set out in this section, the Buyer will not contact any vendor,
customer, supplier, distributor, or employee of the Sellers prior to the Closing
Date without the prior written consent of Instrumentation, which consent, for
the avoidance of doubt, may be provided by email exchange between the Buyer and
the Sellers, and shall not be unreasonably delayed or withheld.

SECTION 7.3. Post-Closing Orders and Payments.

From and after 12:01 A.M. (Eastern Daylight Time) on the day immediately
following the Closing Date, the Sellers shall hold all payments received by the
Sellers from third parties for Products purchased by the third parties on trust
for the Buyer and shall promptly deliver to the Buyer any payments received by
the Sellers and refer all inquiries it receives with respect to the Products to
the Buyer.

SECTION 7.4. Further Actions.

(a) From and after the date of this Agreement and through to Closing, the
Sellers will use reasonable efforts to take, or cause to be taken, all actions
and to do, or cause to be done, all things necessary, proper and advisable, and
assist and cooperate with the other parties in doing all things necessary proper
or advisable, to ensure that the conditions set forth in Article IX are
consummated and made effective, in the most expeditious manner practicable
including (i) obtaining all necessary actions or non-actions, waivers, consents
and approvals from Governmental Entities and making all necessary registrations
and filings and taking all steps as may be necessary to obtain an approval or
waiver from, or to avoid an action or proceeding by, any Governmental Entity,
(ii) obtaining all consents, approvals or waivers from, or taking other actions
with respect to, third parties necessary or advisable to be obtained or taken in
connection with the transactions contemplated by this Agreement; and
(iii) executing and delivering any additional instruments necessary to
consummate the transactions contemplated hereby, and to fully carry out the
purposes of this Agreement.

SECTION 7.5. Notice of Developments

From and after the date of this Agreement and through to Closing, the Sellers
will give prompt written notice to the Buyer of:

(a) any change or event that, individually or in the aggregate, has had or could
reasonably be expected to result in a Material Adverse Change or otherwise
result in any representation or warranty of the Sellers under this Agreement
being inaccurate in any material respect;

 

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(b) any breach by the Sellers of the terms and conditions of this Agreement;

(c) any notice or other communication from any Person alleging that the consent
of such Person is or may be required in connection with the transactions
contemplated by this Agreement;

(d) any notice or other communication from any Governmental Entity in connection
with the transactions contemplated by this Agreement;

(e) any action, suit, claim, investigation or proceeding commenced or, to the
Knowledge of the Sellers, threatened against, relating to or involving or
otherwise affecting the Sellers or the Business that relates to the consummation
of the transactions contemplated by this Agreement; and

(f) the damage or destruction by fire or other casualty of any Purchased Asset
or part thereof or in the event that any Purchased Asset or part thereof becomes
the subject of any proceeding by a Governmental Entity.

SECTION 7.6. Assignment of Contracts, Rights, Etc.

Anything contained in this Agreement to the contrary notwithstanding, this
Agreement shall not constitute an agreement or attempted agreement to transfer,
sublease or assign any Contract, or right with respect to any benefit arising
thereunder or resulting therefrom, or any permit, if an attempted transfer,
sublease or assignment thereof, without the required consent of any other party
thereto, would constitute a breach thereof or in any way adversely affect the
rights of the Buyer thereunder. The Sellers shall use commercially reasonable
efforts to obtain the consent of any such third party to any of the foregoing to
the transfer or assignment thereof to the Buyer in all cases in which such
consent is required for such transfer or assignment. If such consent is not
obtained, the Sellers shall cooperate in any reasonable and lawful arrangements
designed to provide for the Buyer the benefits thereunder.

SECTION 7.7. Confidentiality and Protection of Goodwill.

(a) For the purpose of assuring to the Buyer, the Company and their successors
in title the full benefit and value of the Business and goodwill incidental to
the Business and in further consideration of the agreement of the Buyer to
purchase the Purchased Assets on the terms hereof, the Sellers and OPKO Health
each hereby undertake to the Buyer and the Company that:

 

  (i) it shall (and it shall procure that each of its Affiliates will) keep
confidential and shall not reveal to any person or, through any failure to
exercise all due care and diligence, cause any unauthorized disclosure of any
confidential information concerning the organization, business, finances,
transactions, Know How, Intellectual Property, or affairs of the Business or any
information of a confidential or proprietary nature belonging to any third party
which is in the custody or control of the Business under an obligation (whether
written or implied) of confidentiality (hereinafter in this Section 7.7 called
“Confidential Information”).

 

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  (ii) it shall not use or attempt to use any such Confidential Information in
any manner which may reasonably be expected to injure or cause loss directly or
indirectly to the Buyer or the Company or may be likely to do so; and

 

  (iii) it shall do nothing to harm the Business and the goodwill incidental to
the Business.

(b) The foregoing undertakings are in addition to and without prejudice to any
other duty of confidentiality owed by the Sellers to the Buyer or the Company in
any capacity.

(c) The undertakings contained in Section 7.7(a) shall cease to apply to
information which the parties agree in writing is not confidential, or which
comes into the public domain otherwise than through breach of the provisions of
this Agreement by the Sellers or OPKO Health. Nothing in Section 7.7 shall
prevent the Sellers or OPKO Health from disclosing Confidential Information
which is required to be disclosed by law or for the purposes of any judicial
proceedings or by any taxation authority or by the rules of any stock exchange
or regulatory authority, whether or not having the force of law, to such party
as has required such disclosure. Nothing in this Section 7.7 shall prevent the
Sellers or OPKO Health from disclosing such Confidential Information to its
professional advisers as is reasonably necessary to obtain advice on the
transactions contemplated by this Agreement.

(d) The Sellers and OPKO Health shall not (and shall procure that no Affiliate
will), save as previously agreed in writing with the Buyer, either on its own
account or in conjunction with others, in any capacity whatsoever (including,
but without limitation, acting as a consultant, agent or manager) and whether
directly or indirectly and whether with a view to profit or otherwise:

 

  (i) during the Restricted Period, establish, develop, carry on or assist in
establishing, developing or carrying on, or be engaged, concerned, interested in
or employed by, any business, enterprise or venture competing to a material
extent with the Business as such Business is carried on at the Closing Date
within the United States, Canada or United Kingdom (hereinafter in this Section
called the “Restricted Area”). However, nothing in this Section 7.7(d) shall
prevent the Sellers or OPKO Health (or any Affiliate) from purchasing, holding
or from being beneficially interested in the shares of not more than five (5)%
of any class of shares or securities of any company provided that the Sellers or
OPKO Health (or the relevant Affiliate) is not entitled or able to exercise,
directly or indirectly, management functions or material influence over such
company; or

 

  (ii)

during the Restricted Period solicit, canvass or entice away (or endeavor to
solicit, canvass or entice away) from the Business any person, firm or company
who was at any time during the period of one year immediately

 

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  preceding the Closing Date a customer of or supplier to the Business for the
purpose of offering to such customer or obtaining from such supplier goods or
services similar to or materially competing with those of the Business; or

 

  (iii) during the Restricted Period solicit, canvass or entice away (or
endeavor to solicit, canvass or entice away) any of the Hired Employees or the
Transferring Employees for the purposes of employment of such Hired Employees or
Transferring Employees by any other person in an enterprise or venture competing
to a material extent with the Business and whether or not such person would
commit a breach of contract by reason of leaving service.

(e) The Sellers and OPKO Health each hereby acknowledge and agree that the
undertakings contained in Sections 7.7(a)(i), (ii) and (iii) constitute entirely
separate and independent undertakings on it which are reasonable in the
circumstances of this Agreement and agrees that if one or more is held to be
invalid as an unreasonable restraint of trade or for any other reason then the
remaining undertakings shall remain valid and in so far as any such restriction
would be void as stated but would be valid if the period of application were
reduced or if some part of the undertaking were deleted, the undertaking in
question shall apply with such modification as may be necessary to make it valid
and effective and the Sellers and OPKO Health each agree to execute any further
undertaking in such modified terms if requested to do so by the Buyer.

(f) The Sellers and OPKO Health acknowledge that any breach of the undertakings
in this Section 7.7 may cause the Buyer or the Company irreparable injury and
that monetary damages alone will not be an adequate remedy for any such breach.
In the event of a breach or threatened breach of the said undertakings, the
Sellers and OPKO Health each agree that the Buyer’s and the Company’s remedies
shall include injunctive relief restraining the Sellers and OPKO Health from
breaching the undertakings.

SECTION 7.8. Guarantee.

In consideration of the matters described in this Agreement, and for other good
and valuable consideration, the receipt and sufficiency of which are
acknowledged, OPKO Health hereby unconditionally guarantees the due and punctual
performance of each of the obligations and undertakings of the Sellers under
this Agreement when and to the extent the same are required to be performed and
subject to the terms and conditions hereof.

ARTICLE VIII.

CERTAIN COVENANTS AND AGREEMENTS OF THE BUYER AND THE COMPANY

SECTION 8.1. Shareholder Meeting.

(a) The Company, acting through the Company’s Board of Directors, will as
promptly as practicable, but in any event, within two Business Days following
the date of this Agreement and in consultation with the Sellers duly call and
give notice of a general meeting of

 

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the Company’s shareholders for the purpose of considering and approving the
transactions contemplated by this Agreement (the “Company Shareholders Meeting”)
and shall, subject to any valid exercise of the rights of the Company
Shareholders to the contrary, hold the Company Shareholders Meeting on the date
specified in the notice of the Company Shareholders Meeting, which shall be no
more than [20] days from the date the notice of the meeting is given.

SECTION 8.2. In connection with convening the Company Shareholders Meeting in
accordance with Section 8.1(a), the Company will distribute a circular to the
Company’s shareholders (the “Circular”) following approval of the Circular by
the UK Listing Authority. The Company and the Sellers will cooperate and consult
with each other, their respective counsel and accountants, in the preparation of
the Circular. The Company shall (i) include in the Circular the recommendation
of the Company’s Board of Directors that the Company’s shareholders vote in
favour of the approval of the transactions contemplated by this Agreement (the
“Recommendation”); (ii) use all commercially reasonable efforts to obtain the
affirmative vote of the Company’s shareholders holding the requisite majority of
issued shares of the Company entitled to vote at the Company Shareholders
Meeting (the “Requisite Shareholder Vote”); and (iii) procure that each director
of the Company, subject to his or her duties to the Company as a director,
recommends and continues to recommend to the Company’s shareholders the passing
of the resolution proposed at the Company Shareholders Meeting and shall use his
or her votes, in respect of shares in the Company owned by him or her, to vote
in favour of such resolution.

SECTION 8.3. Books and Records.

(a) For a period of seven years from and after the Closing Date, the Buyer will
preserve all books and records included within the Purchased Assets and will
make such books and records available for inspection and copying by the Sellers
or its agents upon reasonable request and upon reasonable notice to confirm
compliance with this Agreement, at the Sellers’ expense.

(b) The Sellers shall have the right to appoint an independent public accounting
firm reasonably acceptable to the Buyer to audit the records of the Buyer as
necessary to verify all Royalty payments payable pursuant to this Agreement.
Such records shall be open for examination for a period of at least five years
following the end of the calendar quarter to which they pertain. If a deficiency
with regard to any payment hereunder is determined by such accounting firm (such
determination to be final and binding upon all parties), the Buyer shall pay any
deficiency within thirty (30) days of receiving notice thereof along with
interest at the rate of 1.5% per month. If a payment deficiency for a calendar
year exceeds US$25,000 or five percent (5%) of the payments paid for that year,
whichever is less, then the Buyer shall be responsible for paying the Sellers’
reasonable and documented out-of-pocket expenses incurred with respect to such
review/audit. The Sellers may exercise their right of audit no more frequently
than once in any calendar year. The accounting firm shall disclose to the
Sellers only information relating to the accuracy of the Royalty payments.

SECTION 8.4. Employees.

(a) Schedule 5.14(a) sets forth a true and complete list of each employee of the
Sellers relating to the Business. The Buyer or the Company (as applicable) agree
to offer

 

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employment (on an at-will basis) to such employees who continue to be employed
by the Sellers as at the Closing Date, such employment to be on the same or
substantially similar terms to the employees’ current terms (to the extent such
terms have been Disclosed and other than in connection with any Employee Benefit
Plan) to be effective as of the Closing Date (or, in the case of employees who
are on disability or leave of absence, including military leave, effective on
the date they are removed from disability status or return from leave) (“Hire
Date”). All such employees who accept employment with the Buyer or the Company
(as applicable) will become employees of the Buyer or the Company effective as
of the Hire Date (each a “Hired Employee”). Employees who do not accept
employment with the Buyer or the Company will not become employees of the Buyer
or the Company.

(b) The provisions of Section 8.4(a) apply only to those employees based in the
US and Canada. The transfer of employment of the Transferring Employees will be
dealt with in accordance with Appendix 1.

(c) The Buyer and the Company agree to offer the Hired Employees and the
Transferring Employees retention payments in the amount and on the basis set out
in Attachment C.

SECTION 8.5. Bulk Transfer Laws.

The Buyer and the Company hereby waive compliance by the Sellers with the
provisions of any so-called “bulk transfer law” of any jurisdiction in
connection with the sale of the Purchased Assets to the Buyer and the Company
and releases the Sellers from any Liabilities in connection therewith as the
Buyer and the Company are assuming all Liabilities not specifically excluded.

SECTION 8.6. Response to Inquiries and Products Complaints.

Without prejudice to any claims by the Buyer or the Company under the
representations and warranties of the Sellers set out in this Agreement, or
otherwise under this Agreement, after the Closing the Buyer will assume all
responsibility for responding to any Product inquiries or complaints about the
Products, including any and all service, warranty, and repair obligations.

SECTION 8.7. Further Actions.

From and after the date of this Agreement and through to Closing, the Buyer will
use reasonable efforts to take, or cause to be taken, all actions and to do, or
cause to be done, all things necessary, proper and advisable, and assist and
cooperate with the other parties in doing all things necessary proper or
advisable, to ensure that the conditions set forth in Article IX are consummated
and made effective, in the most expeditious manner practicable, the transactions
contemplated hereby, including (i) obtaining all necessary actions or
non-actions, waivers, consents and approvals from Governmental Entities and
making all necessary registrations and filings and taking all steps as may be
necessary to obtain an approval or waiver from, or to avoid an action or
proceeding by, any Governmental Entity, (ii) obtaining all consents, approvals
or waivers from, or taking other actions with respect to, third parties
necessary or advisable to be obtained or taken in connection with the
transactions contemplated by this Agreement; and (iii) executing and delivering
any additional instruments necessary to consummate the transactions contemplated
hereby, and to fully carry out the purposes of this Agreement.

 

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SECTION 8.8. Notice of Developments.

From and after the date of this Agreement and through to Closing, the Buyer will
give prompt written notice to the Sellers of:

(a) any change or event that, individually or in the aggregate, has had or could
reasonably be expected to result in a Material Adverse Change or otherwise
result in any representation or warranty of the Buyer under this Agreement being
inaccurate in any material respect;

(b) any breach by the Buyer of the terms and conditions of this Agreement;

(c) any notice or other communication from any Person alleging that the consent
of such Person is or may be required in connection with the transactions
contemplated by this Agreement;

(d) any notice or other communication from any Governmental Entity in connection
with the transactions contemplated by this Agreement; and

(e) any action, suit, claim, investigation or proceeding commenced or, to the
Knowledge of the Buyer, threatened against, relating to or involving or
otherwise affecting the Buyer that relates to the consummation of the
transactions contemplated by this Agreement.

ARTICLE IX.

CONDITIONS

SECTION 9.1. Conditions to Obligations of the Buyer.

The obligations of the Buyer to purchase the Purchased Assets being sold on the
Closing Date and to assume the related Assumed Liabilities is subject to the
satisfaction on and as of the Closing Date of each of the following conditions:

(a) Representations and Warranties. The representations and warranties of the
Sellers set forth in this Agreement will be true and correct in all material
respects (other than representations and warranties that contain materiality
qualifications, which shall be true and correct in all respects) as of the date
of this Agreement and the Closing Date, except to the extent such
representations and warranties expressly relate to an earlier date (in which
case such representations and warranties will be true and correct as of such
earlier date) and except where the failure of such representations and
warranties to be so true and correct has not had, and would not reasonably be
expected to have, a Material Adverse Change on the Business.

(b) Performance of Obligations of Sellers. The Sellers will have performed or
complied in all material respects with all obligations, conditions and covenants
required to be performed by them under this Agreement or the Transaction
Documents at or prior to the Closing Date.

 

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(c) No Litigation, Injunctions, or Restraints. No temporary restraining order,
preliminary or permanent injunction or other legal restraint or prohibition
preventing the consummation of the transactions contemplated by this Agreement
will be threatened or in effect.

(d) Deliveries. The Sellers will have duly executed and delivered to the Buyer,
dated as of the Closing Date, the documents referred to in Section 4.2(a).

(e) No Material Adverse Change. Since the date of this Agreement, there shall
have been no Material Adverse Change suffered by the Business.

(f) Shareholder Vote. The Company having obtained the Requisite Shareholder
Vote.

SECTION 9.2. Conditions to the Obligations of Sellers.

The obligations of the Sellers to sell, assign, convey, and deliver the
Purchased Assets being sold on the Closing Date to the Buyer are subject to the
satisfaction on and as of the Closing Date of each of the following conditions:

(a) Representations and Warranties. The representations and warranties of the
Buyer set forth in this Agreement will be true and correct in all material
respects (other than representations and warranties that contain materiality
qualifications, which shall be true and correct in all respects) as of the date
of this Agreement and the Closing Date, except to the extent such
representations and warranties expressly relate to an earlier date (in which
case such representations and warranties will be true and correct as of such
earlier date) and except where the failure of such representations and
warranties to be so true and correct has not had, and would not reasonably be
expected to have, a Material Adverse Change on the Buyer.

(b) Performance of Obligations of the Buyer. The Buyer will have each performed
in all material respects all obligations required to be performed by it under
this Agreement or the Transaction Documents at or prior to the Closing Date.

(c) No Litigation, Injunctions, or Restraints. No temporary restraining order,
preliminary or permanent injunction or other legal restraint or prohibition
preventing the consummation of the transactions contemplated by this Agreement
will be threatened or in effect.

(d) Deliveries. The Buyer will have duly executed and delivered to the Sellers,
dated as of the Closing Date, in each case appropriately executed, the documents
referred to in Section 4.2(b).

(e) No Material Adverse Change. Since the date of this Agreement, there shall
have been no Material Adverse Change suffered by the Buyer.

 

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ARTICLE X.

TERMINATION, AMENDMENT AND WAIVER

SECTION 10.1. Termination.

(a) Notwithstanding anything to the contrary in this Agreement, this Agreement
may be terminated and the transactions contemplated hereby abandoned at any time
prior to the Closing:

 

  (i) by mutual written consent of the Sellers, on the one hand, and the Buyer,
on the other hand;

 

  (ii) by the Buyer if the conditions under Section 9.1 have not been met and
Closing has not occurred prior to November 30, 2011 (the “Long Stop Date”), and
by the Sellers if the conditions under Section 9.2 have not been met and Closing
has not occurred prior to the Long Stop Date, provided the failure of the
Closing to occur by such date is not the result of the party seeking to
terminate this Agreement to perform or fulfill any of its obligations hereunder;

 

  (iii) by the Sellers or the Buyer if the Company fails to obtain the Requisite
Shareholder Vote at the Company Shareholders Meeting or any adjournment thereof;

 

  (iv) by the Sellers if the Buyer commits a material breach of any obligation,
condition or covenant contained in this Agreement or the Transaction Documents
that is incapable of remedy prior to the Long Stop Date;

 

  (v) by the Buyer if the Sellers commit a material breach of any obligation,
condition or covenant contained in this Agreement or the Transaction Documents
that is incapable of remedy prior to the Long Stop Date;

 

  (vi) by the Sellers, if (i) the Board of Directors of the Company or any
committee thereof shall have failed to recommend to the Company’s shareholders
that they approve the transaction contemplated by this Agreement or otherwise
comply with Sections 8.1 and 8.2, (ii) the Board of Directors of the Company or
any committee thereof shall have recommended that the Company’s shareholders
vote against the transaction contemplated by this Agreement, or (iii) the Board
of Directors of the Company or any committee thereof takes or determines to take
any of the foregoing actions.

(b) Effect of Termination. If this Agreement is terminated pursuant to
Section 10.1, written notice thereof shall promptly be given by the party
electing such termination to the other party and this Agreement shall terminate
without further actions by the parties and no party shall have any further
obligations under this Agreement except as provided in Section 10.1(c) below,
and further provided that any termination of this Agreement pursuant to this
Section shall not relieve any party from any liability for the breach of any
representation, warranty or covenant contained in this Agreement prior to the
date of termination or be deemed to constitute a waiver of any remedy available
for such breach.

 

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(c) Non-fulfillment of Conditions. In recognition of the Sellers expending
considerable time, resource and effort in connection with the transactions
contemplated hereby, in the event that the Sellers terminate the Agreement under
Sections 10.1(a)(iii), (iv) or (vi) on or prior to the Long Stop Date, then the
Buyer hereby covenants to pay on demand to the Sellers the sum of US$750,000.

(d) Return of Confidential Materials. Upon termination of this Agreement for any
reason, the Buyer will immediately return all documents and other material
received from the Sellers relating to the Business, the Products, the Purchased
Assets and the transactions contemplated hereby, whether so obtained before or
after the execution hereof. Further, the Buyer agrees to treat as confidential,
all confidential and proprietary information received from the Sellers and their
representatives relating to the Sellers, the Business, the Products or the
Purchased Assets.

SECTION 10.2. Amendments and Waivers.

This Agreement may not be amended except by an instrument in writing signed on
behalf of each of the parties hereto. By an instrument in writing, the Buyer and
the Company, on the one hand, or the Sellers, on the other hand, may waive
compliance by the other parties with any term or provision of this Agreement
that such other parties were or are obligated to comply with or perform.

ARTICLE XI.

SURVIVAL AND INDEMNIFICATION

SECTION 11.1. Survival. Each of the representations and warranties of the
Sellers and the Buyer shall survive the Closing hereunder and continue in full
force and effect until 31 October 2012, following which no claim may be made
under the representations and warranties of the Sellers by the Buyer or the
Company or of the Buyer by the Sellers as applicable unless the Buyer, the
Company or the Sellers, as applicable, have been notified in writing of the
existence of, and reasonable details regarding (including insofar as practicable
an estimate of the amount of the liability under), such claim prior to
31 October 2012. Subject to the foregoing, any covenant of any Seller or the
Buyer contained in this Agreement shall survive the date hereof until such
covenant has been fully performed and satisfied.

SECTION 11.2. Indemnification Provisions for the Buyer’s and the Company’s
Benefit.

(a) Seller Breach. In the event the Sellers breach any of their respective
representations, warranties, and covenants contained in this Agreement or in any
certificate or instrument delivered in connection with the transactions
contemplated hereby that relate to such representations, warranties or
covenants, and, provided that the Buyer or the Company provide a written notice
of the claim for indemnification against the Sellers in accordance with this
Agreement within the applicable survival period set forth in Section 11.1, then
each Seller shall jointly and severally indemnify, and hold harmless the Buyer,
the Company and their respective

 

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Affiliates, officers, directors, employees and agents (collectively, the “Buyer
Indemnified Parties”) from and against any and all liabilities, losses,
injuries, damages, assessments, judgments, costs and expenses, including without
limitation the cost of any investigation or lawsuit and reasonable attorneys’
fees relating thereto and including any diminution in value of the Business
(collectively, “Losses”) caused by such breach. In addition, each Seller shall
jointly and severally indemnify and hold harmless the Buyer Indemnified Parties
from and against any Losses the Buyer Indemnified Parties shall suffer arising
out of or resulting, directly or indirectly, from any Excluded Liabilities and
any Excluded Assets.

(b) Minimum Loss. Notwithstanding the foregoing, the Sellers shall not be liable
to the Buyer Indemnified Parties for indemnification pursuant to Section 11.2(a)
if, with respect to any individual item of loss or claim for indemnification, as
the case may be (with it being understood, however, that all Losses or claims
arising out of the same or similar facts, events or circumstances shall be
considered an individual Loss or claim for purposes of this Agreement and all
such items shall be aggregated for purposes of this Section 11.2(b)), such item
or claim is less than US$10,000 (“Minor Claim”), it being understood that no
Minor Claim shall apply or be counted towards the Indemnification Threshold,
and, furthermore, the Sellers shall have no obligation to indemnify the Buyer
Indemnified Parties until the Buyer Indemnified Parties have suffered Losses by
reason of all breaches under this Agreement in excess of Two Hundred Thousand
Dollars (US$200,000) (the “Indemnification Threshold”), after which point the
Sellers will be obligated only to indemnify the Buyer Indemnified Parties from
and against Losses in excess of the Indemnification Threshold. In no event shall
the Sellers have any obligation to indemnify the Buyer Indemnified Parties
pursuant to Section 11.2 to the extent and in the amount that such Losses exceed
Ten Million Dollars (US$10,000,000) (the “Maximum Amount”). Notwithstanding
anything contained in this Section 11.2(b) or elsewhere in this Agreement to the
contrary, in no event shall the Indemnification Threshold or the Maximum Amount
apply to any action arising from fraud, intentional misrepresentation or willful
breach by any Sellers of any term or provision of this Agreement, the
Transaction Documents or any other documents contemplated in connection with the
consummation of the transactions contemplated hereby. Nor shall such
Indemnification Threshold or Maximum Amount apply to any Liability relating to
any Excluded Asset or Excluded Liability.

SECTION 11.3. Indemnification Provisions for the Sellers’ Benefit.

In the event the Buyer breaches any of its representations, warranties, and
covenants contained in this Agreement or in any certificate or instrument
delivered in connection with the transactions contemplated hereby that relate to
such representations, warranties or covenants, and provided that the Sellers
make a written claim for indemnification against the Buyer in accordance with
this Agreement within the applicable survival period set forth in Section 11.1,
then the Buyer shall indemnify, hold harmless and reimburse the Sellers and
their respective Affiliates, officers, directors, employees and agents
(collectively, the “Seller Indemnified Parties”) from and against any and all
Losses caused by the breach. In addition, the Buyer shall indemnify and hold
harmless the Seller Indemnified Parties from and against any Losses the Seller
Indemnified Party shall suffer arising out of or resulting, directly or
indirectly, from any Purchased Asset or any Assumed Liability, or any Liability
associated with or arising out of or in connection with the ownership of such
Purchased Assets or Assumed Liabilities or the operation of the Business (except
to the extent such Liability results from a breach by the Sellers of a

 

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representation, warranty, or covenant contained in this Agreement).
Notwithstanding the foregoing, the Buyer shall have no obligation to indemnify
the Seller Indemnified Parties until they have suffered Losses by reason of all
such breaches in excess of the Indemnification Threshold, after which point the
Buyer will be obligated only to indemnify the Seller Indemnified Parties from
and against Losses in excess of the Indemnification Threshold. In no event shall
the Buyers have any obligation to indemnify the Sellers pursuant to this
Section 11.3 to the extent and in the amount that such Losses exceed the Maximum
Amount. Notwithstanding anything contained in this Section 11.3 or elsewhere in
this Agreement to the contrary, in no event shall the Indemnification Threshold
or the Maximum Amount apply to any action arising from fraud, intentional
misrepresentation or willful breach by the Buyer of any term or provision of
this Agreement or any other documents contemplated in connection with the
consummation of the transactions contemplated hereby. Nor shall such
Indemnification Threshold or Maximum Amount apply to any Liability relating to
any Purchased Asset, Assumed Liability, or any other Liability associated or
arising out of or in connection with the ownership of such Purchased Assets or
Assumed Liabilities or the operation of the Business (other than Excluded Assets
and Excluded Liabilities).

SECTION 11.4. Methods of Asserting Claims.

(a) Notice. The party seeking indemnity (“Indemnitee”) will give prompt written
notice to the party or parties providing indemnity (“Indemnitor”) of any claim
which it discovers or of which it receives notice after the Closing, stating the
nature, basis and (to the extent known) amount thereof; provided, however, that
no delay on the part of Indemnitee in notifying any Indemnitor shall relieve
Indemnitor from any Liability hereunder unless (and then solely to the extent)
Indemnitor is prejudiced by such delay. Copies of any papers received in
connection with a claim shall be forwarded to Indemnitor together with the
notice of the claim.

(b) Procedure. In case of any suit, claim or proceeding by a third party or by
any Governmental Authority, or any action involving claims brought by such a
third party or Governmental Authority with respect to which Indemnitor may have
Liability under the indemnification provisions contained in this Section 11.4 (a
“Third-Party Claim”), if Indemnitor acknowledges in writing delivered to
Indemnitee that Indemnitor is obligated hereunder in connection with such
Third-Party Claim, then Indemnitor shall have the right to assume the defense
thereof at its own expense and by its own counsel, which counsel shall be
reasonably satisfactory to Indemnitee; provided, however, that Indemnitor shall
not have the right to assume the defense of such Third-Party Claim,
notwithstanding the giving of such written acknowledgement, if (i) the
Third-Party Claim seeks only an injunction or other equitable relief,
(ii) Indemnitee shall have been advised by counsel that there are one or more
legal or equitable defenses available to Indemnitee that are different from or
in addition to those available to Indemnitor and, in the reasonable opinion of
Indemnitee, counsel for Indemnitor could not adequately represent Indemnitee’s
interests because they conflict with those of Indemnitor, (iii) such Third-Party
Claim involves, or could have a material effect on, any material matter beyond
the scope of the indemnification obligation of Indemnitor or (iv) Indemnitor
shall not have assumed the defense of such Third-Party Claim in a timely
fashion. If Indemnitor shall assume the defense of a Third-Party Claim (under
circumstances in which the proviso in the preceding sentence is not applicable),
Indemnitor shall not be responsible for any legal or other defense costs
subsequently incurred by Indemnitee in connection with the defense thereof. If
Indemnitor

 

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does not exercise its rights to assume the defense of a Third-Party Claim by
giving the required written acknowledgement, or is otherwise restricted from so
assuming such defense, Indemnitor shall nevertheless be entitled to participate
in such defense with its own counsel and at its own expense; and in any such
case Indemnitee may assume the defense of the Third-Party Claim, with counsel
that shall be reasonably satisfactory to Indemnitor, and shall act reasonably
and in accordance with its good faith business judgment and shall not affect any
settlement without the consent of Indemnitor, which consent shall not be
unreasonably withheld or delayed. If Indemnitor exercises its right to assume
the defense of a Third-Party Claim, it shall not effect any settlement without
the consent of Indemnitee, which consent shall not be unreasonably withheld or
delayed.

(c) Determination of Adverse Consequences. All indemnification payments under
this Article XI shall be paid by the Indemnifying Party net of any Tax or
insurance benefits actually received (net of any increased insurance premiums)
by the Indemnified Party. All indemnification payments under this Article XI
shall be deemed adjustments to the Purchase Price.

(d) Exclusive Remedy. In the absence of fraud, intentional misrepresentation or
willful breach, after the Closing, the Buyer, the Company and the Sellers
acknowledge and agree that the foregoing indemnification provisions in this
Article XI shall be the sole and exclusive remedy of the Buyer, the Company and
the Sellers with respect to all monetary Losses arising under this Agreement of
any kind or nature, including, without limitation, for any misrepresentation or
breach of any warranty, covenant or other provision contained in this Agreement.
In no event shall any party be responsible for lost profits or consequential
damages of any other party hereto irrespective whether they were advised of the
possibility of such damages.

(e) Other limitations. The Buyer or the Company shall not be entitled to claim
against the Sellers under the representations, warranties or any other provision
of this Agreement:

 

  (i) in respect of any matters Disclosed; or

 

  (ii) in respect of any matter or thing after the date of this Agreement done
or omitted to be done by the Sellers at the request of, or with the consent of,
the Buyer.

(f) The Buyer or the Company shall not be entitled to recover more than once in
respect of any fact, matter, event or circumstance giving rise to a claim under
the representations, warranties or any other provision of this Agreement.

(g) Each of the Sellers and the Buyer shall and shall procure that their
respective Affiliates will in relation to any loss or liability which might give
rise to a claim under the representations, warranties or any other provision of
this Agreement against the Buyer or the Sellers as applicable, use reasonable
endeavours to avoid or mitigate that loss or liability.

 

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ARTICLE XII.

GENERAL PROVISIONS

SECTION 12.1. Expenses.

All costs and expenses, including fees and disbursements of counsel, financial
advisors and accountants, incurred in connection with this Agreement and the
transactions contemplated hereby will be paid by the party incurring such costs
and expenses.

SECTION 12.2. Further Assurances and Actions.

(a) Each of the parties hereto, upon the request of the other parties hereto,
whether before or after the Closing and without further consideration, will do,
execute, acknowledge and deliver or cause to be done, executed, acknowledged or
delivered all such further acts, deeds, documents, assignments, transfers,
conveyances, powers of attorney and assurances as may be reasonably necessary to
effect complete consummation of the transactions contemplated by this Agreement.
The Sellers and the Buyer agree to execute and deliver such other documents,
certificates, agreements and other writings and to take such other actions as
may be reasonably necessary in order to consummate or implement expeditiously
the transactions contemplated by this Agreement.

(b) For the avoidance of doubt, the Sellers shall perform (or procure the
performance of) all further acts and things, and execute and deliver (or procure
the execution and delivery of) all further documents required by law or which
the Buyer requests to vest in the Buyer the full benefit of the right, title and
interest assigned to the Buyer under this Agreement.

SECTION 12.3. Notices.

All notices and other communications required or permitted to be given or made
pursuant to this Agreement shall be in writing signed by the sender and shall be
deemed duly given (a) on the date delivered, if personally delivered, (b) on the
date sent by telecopier with automatic confirmation by the transmitting machine
showing the proper number of pages were transmitted without error, (c) on the
Business Day after being sent by Federal Express or another recognized overnight
mail service which utilizes a written form of receipt for next day or next
business day delivery or (d) two (2) Business Days after mailing, if mailed by
postage-prepaid certified or registered mail, return receipt requested, in each
case addressed to the applicable party at the address set forth below; provided
that a party may change its address for receiving notice by the proper giving of
notice hereunder:

if to the Sellers, to:

OPKO Instrumentation, LLC

4400 Biscayne Blvd.

Miami, Florida 33137

Attn:    Dr. Jane Hsiao Fax:    (305) 575-4130

 

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With a copy to:

OPKO Instrumentation, LLC

4400 Biscayne Blvd.

Miami, Florida 33137

Attn:    Legal Department Fax:    (305) 575-4140

if to the Buyer, to:

Optos plc

Queensferry House

Carnegie Business Campus

Dunfermline, Fife

Scotland KY11 8GR

Attn: Christine Soden

Fax: +44 1383 843 333

With a copy to: Maclay Murray & Spens LLP by fax on +44 20 7002 8501 (FAO: Guy
Norfolk)

SECTION 12.4. Interpretation.

(a) The table of contents and headings contained in this Agreement are for
reference purposes only and will not affect in any way the meaning or
interpretation of this Agreement.

(b) A reference in this Agreement to the singular includes a reference to the
plural and vice versa and a reference to any gender includes a reference to all
other genders.

(c) A reference in this Agreement to “including” shall, unless the context
otherwise requires, be deemed to be immediately followed by the words “without
limitation”.

SECTION 12.5. Severability.

If any term or other provision of this Agreement is invalid, illegal or
incapable of being enforced under any law or public policy, all other terms and
provisions of this Agreement will nevertheless remain in full force and effect
so long as the economic or legal substance of the transactions contemplated
hereby is not affected in any manner materially adverse to any party. Upon such
determination that any term or other provision is invalid, illegal or incapable
of being enforced, the parties hereto will negotiate in good faith to modify
this Agreement so as to effect the original intent of the parties hereto as
closely as possible in an acceptable manner in order that the transactions
contemplated hereby are consummated as originally contemplated to the greatest
extent possible.

 

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SECTION 12.6. Counterparts.

This Agreement may be executed in one or more counterparts, all of which will be
considered one and the same agreement and will become effective when one or more
counterparts have been signed by each of the parties hereto and delivered to the
other parties hereto, it being understood that all parties hereto need not sign
the same counterpart.

SECTION 12.7. Entire Agreement; No Third-Party Beneficiaries.

This Agreement and the Exhibits, Annexures and Schedules hereto constitute the
entire agreement and supersede all prior agreements and understandings, both
written and oral (including any letter of intent, memorandum of understanding or
term sheet), between or among the parties hereto with respect to the subject
matter hereof. Except as specifically provided herein, this Agreement is not
intended to confer upon any Person other than the parties hereto any rights or
remedies hereunder or thereunder.

SECTION 12.8. Governing Law.

This Agreement and any and all matters arising directly or indirectly herefrom
shall be governed by and construed and enforced in accordance with the laws of
England applicable to agreements made and to be performed entirely in England.

SECTION 12.9. Specific Performance.

The parties hereto agree that irreparable damage would occur in the event any
provision of this Agreement were not performed in accordance with its terms and
that the parties hereto will be entitled to specific performance of such terms,
in addition to any other remedy at law or in equity, without the necessity of
demonstrating the inadequacy of monetary damages and without the posting of a
bond.

SECTION 12.10. Publicity.

A party may make any public disclosure concerning the transactions contemplated
hereby that in the view of such party’s counsel may be required by law or the
rules of any stock exchange on which such party’s or its Affiliates’ securities
trade; provided, however, the party making such disclosure will provide the
non-disclosing party with a copy of the intended disclosure reasonably, and to
the extent practicable, prior to public dissemination, and the parties hereto
will coordinate with one another regarding the timing, form and content of such
disclosure.

SECTION 12.11. Assignment.

No party may assign, novate or otherwise transfer its rights or obligations
under this Agreement without the prior written consent of the other party;
provided, however, that either party may assign or otherwise transfer its rights
and obligations under this Agreement, without the prior written consent of the
other party, to an Affiliate or to a successor of the assigning party by reason
of merger, sale of all or substantially all of its assets or any similar
transaction. Notwithstanding the preceding sentence, if an assignee or successor
is resident in a Tax

 

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jurisdiction that will impose withholding or other Taxes on Royalties due under
this Agreement, the Sellers shall be entitled to a gross-up payment on such
Royalties such that the net amount of Royalties, after withholding or other
Taxes (including the gross-up payment), is equal to the amount Seller is
entitled to under this Agreement prior to any such Assignment. For clarity,
Sellers shall be permitted to assign their rights to receive the Royalty to a
third party without the consent of the Buyer. Any permitted assignee or
successor-in-interest will assume all obligations of its assignor under this
Agreement. No assignment or transfer will relieve either party of its
responsibility for the performance of any obligation. This Agreement will be
binding upon and inure to the benefit of the parties hereto and their respective
successors and permitted assigns and transferees. For the avoidance of doubt,
the Sellers acknowledge that some or all of the Purchased Assets may be
transferred or assigned by the Buyer to the Company or any of their Affiliates
following Closing, and nothing within this Agreement will be deemed to restrict
or prevent such transfer or assignment.

SECTION 12.12. Amendments and Waivers.

This Agreement may not be amended except by an instrument in writing signed on
behalf of each of the parties hereto. By an instrument in writing, the Buyer and
the Company, on the one hand, or the Sellers, on the other hand, may waive
compliance by the other party with any term or provision of this Agreement that
such other party was or is obligated to comply with or perform.

 

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IN WITNESS WHEREOF, the parties hereto have caused this Asset Purchase Agreement
to be signed by their respective representatives thereunto duly authorized, all
as of the date first written above.

 

OPKO HEALTH, INC.

By:

 

/s/ Steven D. Rubin

Name:

 

Steven D. Rubin

Title:

 

Executive Vice President - Administration

OPKO INSTRUMENTATION, LLC

By:  

/s/ Steven D. Rubin

Name:  

Steven D. Rubin

Title:  

Executive Vice President

OPHTHALMIC TECHNOLOGIES, INC.

By:  

/s/ Steven D. Rubin

Name:  

Steven D. Rubin

Title:  

Vice President

OTI (UK) LIMITED

By:  

/s/ Steven D. Rubin

Name:  

Steven D. Rubin

Title:  

President

OPTOS PLC

By:  

/s/ Christine Soden

Name:  

Christine Soden

Title:  

Chief Financial Officer

 

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OPTOS INC.

By:  

/s/ Christine Soden

Name:  

Christine Soden

Title:  

Vice President and Chief Financial Officer

 

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Appendix 1

 

1. TRANSFERRING EMPLOYEES

 

1.1 Apportionment of employee costs

All salaries and other emoluments of the Transferring Employees shall be
discharged and all Pay As You Earn, income tax deduction and national insurance
contribution legislation and regulations shall be complied with by the Seller in
respect of all periods up to and including the Closing Date and in respect of
all share options granted prior to the Closing Date even if exercised after the
Closing Date. The salaries and other emoluments of the Transferring Employees in
respect of the period after the Closing Date shall be for the account of the
Buyer.

 

1.2 Application of the Regulations

OTI UK and the Buyer acknowledge and agree that the Regulations will apply to
the sale and purchase of the Business under this Agreement (to the extent
situated in the UK) and to the Transferring Employees save for any provisions
relating to any benefits under an occupational pension scheme for old age,
invalidity or survivors which do not transfer under the Regulations.

 

1.3 Seller’s indemnity

The Sellers shall indemnify the Buyer against any act or omission of OTI UK
prior to Closing arising out of or relating to the employment or termination of
employment of any of the Transferring Employees and any failure by the Sellers
to comply with their obligations under the Employment Regulations to inform and
consult appropriate representatives of the Transferring Employees in good time
before Closing.

 

1.4 Buyer’s indemnity

The Buyer shall indemnify the Sellers against:

 

  (a) any act or omission of the Buyer arising out of or relating to the
employment or termination of employment of any of the Transferring Employees
after Closing;

 

  (b) any substantial changes to the working conditions of any of the
Transferring Employees to their material detriment which are made, proposed or
anticipated to take effect after Closing and any right of any Transferring
Employee to terminate his contract of employment without notice in acceptance of
a repudiatory breach of his contract by the Buyer;

 

  (c) any breach by the Buyer of Regulation 13(4) of the Regulations;

 

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1.5 Transferring Employees not covered by the Regulations

If any contract of employment (including any rights, powers, duties and
liabilities under or in connection with that contract) of any Transferring
Employee is found or alleged to continue with the Sellers after Closing, the
Buyer agrees that:

 

  (a) in consultation with the Sellers, they will within seven Business Days of
discovering such a finding or allegation make to that person an offer in writing
to employ him or her under a new contract of employment to take effect upon the
termination referred to below; and

 

  (b) that offer of employment will be on terms and conditions which, when taken
as a whole, do not materially differ from the terms and conditions of employment
of that person immediately before Closing (save as to the identity of the
employer and any terms relating to an occupational pension scheme)

Upon that offer being made by the Buyer, or at any time after the expiry of
seven Business Days from a request by the Sellers for the Buyer to make that
offer, OTI UK shall terminate the employment of the Transferring Employee
concerned and the Buyer shall be responsible for and indemnify the Sellers
against all costs, claims, expenses and liabilities arising from:

 

  (A) the employment of that Transferring Employee from Closing until the
termination of that employment; and

 

  (B) that termination (including any redundancy pay and compensation for unfair
or wrongful dismissal or breach of contract).

 

1.6 Undisclosed Employees

If after Closing any contract of employment relating to an individual who is not
a Transferring Employee shall have effect as if originally made between the
Buyer and the individual or any individual claims that their contract has this
effect (together the “Undisclosed Employee”) the Buyer may forthwith terminate
the employment of the Undisclosed Employees and the Sellers shall indemnify the
Buyer against all costs, claims, expenses and liabilities arising from:

 

  (a) the employment of any Undisclosed Employee from Closing until the
termination of that employment; and

 

  (b) that termination (including any redundancy pay and compensation for unfair
or wrongful dismissal or breach of contract).

 

49

--------------------------------------------------------------------------------

Where there is an Undisclosed Employee:

 

  (A) a party shall notify the other in writing as soon as practicable and in
any case within 5 Business Days after becoming aware of an Undisclosed Employee
and the parties shall consult in good faith as to the appropriate steps to be
taken in relation to this;

 

  (B) if, within 10 Business Days of notification under this clause 1.6, the
Sellers and the Buyer fails to reach agreement, the Sellers may offer to
re-employ the Undisclosed Employee;

 

  (C) if no such offer of employment has been made by the Sellers to the
Undisclosed Employee or if made is not accepted by the Undisclosed Employee
within 20 Business Days of the notification referred to in this clause 1.6, the
Buyer may terminate the employment contract of the Undisclosed Employee.

 

1.7 Mutual assistance

The Sellers and the Buyer shall give each other any assistance that either may
reasonably require to comply with the Regulations in relation to the
Transferring Employees and in contesting any claim by any person employed or
engaged in the Business at or before Closing resulting from or in connection
with this Agreement.

 

1.8 Access to Transferring Employees

The Sellers and the Buyer shall respectively consult and keep each other fully
informed regarding any information they propose to give to the Transferring
Employees and their representatives or any consultation they have with the
Transferring Employees and their representatives regarding this Agreement prior
to Closing. Except as otherwise provided in this Agreement, the Buyer
acknowledges that it shall not have any contact with the Transferring Employees
unless previously agreed in writing with the Sellers.

 

1.9 Employee Liability Information

The parties confirm that it is their intention that the provision of Employee
Liability Information is regulated by the parties themselves in accordance with
the commercial arrangements set out in this Agreement. In particular but without
limitation:

 

  (a) the Buyer specifically undertakes that it will not make any application
pursuant to Regulation 12 of the Regulations in respect of any failure or
alleged failure by the Sellers to provide Employee Liability Information to the
Buyer;

 

  (b) the Buyer confirms that it would not be just or equitable for any court or
tribunal to make any award pursuant to Regulation 12(3) of the Regulations given
the terms of this Agreement. If, contrary to the intentions of the parties, any
award is made pursuant to Regulation 12(3) of the Regulations, the Buyer will
indemnify and keep indemnified the Sellers against any compensation, fines,
legal fees, or any other losses of whatsoever nature as a result of such award.

 

50

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Attachment A

Bill of Sale and Assignment and Assumption Agreement

 

51

--------------------------------------------------------------------------------

BILL OF SALE, ASSIGNMENT AND ASSUMPTION

AGREEMENT

THIS BILL OF SALE, ASSIGNMENT AND ASSUMPTION AGREEMENT is dated as of
October 11, 2011 (this “Agreement”) by and between Optos Inc. (the “Buyer”), and
OPKO Instrumentation, LLC, a Delaware limited liability company
(“Instrumentation”), Ophthalmic Technologies, Inc., an Ontario corporation
(“OTI”) and OTI (UK) Limited, a company incorporated in England (“OTI UK”, with
each of Instrumentation, OTI and OTI UK being referred to as a “Seller”, and
together the “Sellers”).

RECITALS:

A. The Buyer, Sellers, Optos plc (a company incorporated in Scotland with
registered number SC139953), and OPKO Health, Inc., a Delaware corporation, have
entered into that certain Asset Purchase Agreement dated as of September 21,
2011 (as amended, restated, supplemented or otherwise modified from time to
time, the “Asset Purchase Agreement”), providing, subject to the terms and
conditions set forth therein, for the sale, transfer, assignment, conveyance and
delivery by the Sellers to the Buyer of all of the Sellers’ right, title and
interest in and to the Purchased Assets (as defined in the Asset Purchase
Agreement) and the assignment and transfer of the Assumed Liabilities (as
defined in the Asset Purchase Agreement).

B. The parties hereto desire to execute and deliver this Agreement for the
purpose of effecting the sale, transfer, assignment, conveyance and delivery of
all of the Sellers’ right, title and interest in and to the Purchased Assets and
to assign and transfer the obligations under the Assumed Liabilities to the
Buyer, and the Buyer is willing to assume the Assumed Liabilities upon the terms
and conditions set forth herein and as contemplated pursuant to the Asset
Purchase Agreement.

NOW, THEREFORE, in consideration of the mutual agreements contained herein and
in the Asset Purchase Agreement, and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, the Sellers and
the Buyer hereby agree as follows:

1. Definitions. Unless otherwise defined herein, each capitalized term used
herein shall have the meaning assigned thereto in the Asset Purchase Agreement.

2. Transfer of the Purchased Assets.

(a) The Sellers hereby sell, transfer, assign, convey and deliver to the Buyer
free and clear from all Encumbrances other than Permitted Encumbrances, to have
and to hold forever, all of the Sellers’ right, title and interest in and to the
Purchased Assets.

(b) Notwithstanding anything in this Agreement to the contrary, the Sellers are
retaining ownership and possession of, and are not selling, transferring,
assigning, conveying, or delivering to the Buyer hereunder or otherwise, any
right, title or interest of the Sellers in and to the Excluded Assets.

--------------------------------------------------------------------------------

(c) Each of the Buyer and the Sellers agree that it shall do, execute,
acknowledge and deliver all acts, agreements, instruments, and assurances as may
be reasonably requested by the other party to further effect and evidence the
transactions contemplated hereby.

3. Assumption of the Assumed Liabilities.

(a) The Sellers hereby assign and delegate to the Buyer, and the Buyer agrees to
perform, and in due course pay and discharge, the Assumed Liabilities.

(b) Notwithstanding any other term of this Agreement, the Sellers are not
assigning or transferring, and the Buyer is not assuming or agreeing to pay,
perform or discharge, any of the Excluded Liabilities which will continue to be
the responsibility of the Sellers.

4. Amendment. This Agreement may be amended only with the express written
consent of both parties.

5. No Third-Party Beneficiary. This Agreement is being entered into solely for
the benefit of the parties hereto, and the parties do not intend that any
employee or any other Person shall be a third-party beneficiary of the covenants
by either the Sellers or the Buyer contained in this Agreement.

6. Governing Law. This Agreement and any and all matters arising directly or
indirectly herefrom shall be governed by and construed and enforced in
accordance with the laws of England applicable to agreements made and to be
performed entirely in England.

7. Counterparts. This Agreement may be executed in counterparts, each of which
shall be deemed an original, but all of which, together, shall constitute one
and the same instrument.

8. Successors and Assigns. This Agreement shall be binding upon and inure to the
benefit of the parties hereto and their respective successors and assigns.

9. Asset Purchase Agreement. Notwithstanding anything in this Agreement to the
contrary, the sale, transfer, assignment, conveyance and delivery effectuated
hereby are subject in all respects to the terms and conditions of the Asset
Purchase Agreement. In the event of any conflict between the provisions of this
Agreement and the terms and conditions of the Asset Purchase Agreement, the
terms and conditions of the Asset Purchase Agreement shall prevail.

[signature page follows]

 

2

--------------------------------------------------------------------------------

IN WITNESS WHEREOF, the undersigned have caused this Bill of Sale, Assignment
and Assumption Agreement to be duly executed as of the date first written above.

 

Optos Inc. By:  

/s/ Christine Soden

Name:  

Christine Soden

Title:  

Vice President and Chief Financial Officer

OPKO Instrumentation, LLC By:  

/s/ Steven D. Rubin

Name:  

Steven D. Rubin

Title:  

Executive Vice President

OTI (UK) Limited By:  

/s/ Steven D. Rubin

Name:  

Steven D. Rubin

Title:  

President

Ophthalmic Technologies, Inc.

By:  

/s/ Steven D. Rubin

Name:  

Steven D. Rubin

Title:  

Vice President

 

3

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Attachment B

Transitional Services Agreement

 

52

--------------------------------------------------------------------------------

maclay murray & spens LLP

DATED 11 October 2011

TRANSITIONAL SERVICES AGREEMENT

between

OPKO HEALTH INC

OPKO INSTRUMENTATION, LLC

OPTOS INC

and

OPTOS PLC

One London Wall London EC2Y SAB DX 123 LONDON/CHANCERY LN

Tel 020 7002 8500 Fax 020 7002 8501

www.mms.co.uk

Ref: SESB/GAN/OPT/0009/00027

--------------------------------------------------------------------------------

TABLE OF CONTENTS

 

Clause        Page No.   1   DEFINITIONS      1    2   CONDITION      2    3  
PROVISION OF SERVICES      2    4   TERM      2    5   FEES      2    6  
SUPPLIERS’ GROUP POLICIES      3    7   TERMINATION      3    8   GENERAL
OBLIGATIONS      3    9   CONFIDENTIALITY      4    10   NO PARTNERSHIP OR
AGENCY    11   VAT      4    12   ASSIGNMENT AND SUBCONTRACTING      5    13  
NOTICES      5    14   SEVERANCE      5    15   THIRD PARTIES      5    16  
COSTS      5    17   WAIVER AND CUMULATIVE REMEDIES      5    18   VARIATION   
  6    19   COUNTERPARTS      6    20   ENTIRE AGREEMENT      6    21  
GOVERNING LAW AND JURISDICTION      6      SCHEDULE - SERVICES      7   

--------------------------------------------------------------------------------

THIS TRANSITIONAL SERVICES AGREEMENT (the “Agreement”) is made on 11th day of
October 2011

BETWEEN

 

(1) OPKO HEALTH INC, a corporation organised and existing under the laws of the
State of Delaware and OPKO INSTRUMENTATION LLC, a limited liability company
organised and existing under the laws of the State of Delaware, each of whose
principal address is 4400 Biscayne Blvd., Miami, Florida 33137 (together the
“Suppliers”); and

 

(2) OPTOS INC, a corporation organised and existing under the laws of the State
of Delaware and OPTOS PLC, a company incorporated in Scotland with registered
number SC139953 (the “Recipients”).

WHEREAS

 

(A) The Suppliers and Recipients are parties to the Asset Purchase Agreement (as
defined below) pursuant to which, among other things, the Recipients will, at
the Closing, acquire substantially all of the assets and liabilities of the
Business, all on the terms and conditions set forth therein.

 

(B) The Parties seek an orderly transition of the Business from the Suppliers to
the Recipients following the Closing and, accordingly, the Suppliers have agreed
that they will for a limited period of time provide, or procure the provision
of, certain services to the Recipients in connection with the sale and transfer
of the Business to the Recipients in accordance with the terms of this
Transitional Services Agreement (the “Agreement”).

NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency
of which are hereby acknowledged, IT IS HEREBY AGREED as follows:-

 

1. DEFINITIONS

 

1.1 In this Agreement unless the context otherwise requires, the following words
and expressions shall have the respective meanings ascribed to them below:

 

“Asset Purchase

Agreement”

   mean the asset purchase agreement dated 21 September 2011 between, amongst
others, the Suppliers and the Recipients;

“Business”

   has the meaning ascribed to it in the Asset Purchase Agreement;

“Business Days”

   means a day (other than a Saturday, Sunday or public holiday) when banks in
London are open for business;

“Closing”

   has the meaning ascribed to it in the Asset Purchase Agreement;

“Closing Date”

   has the meaning ascribed to it in the Asset Purchase Agreement;

“Group”

   means in relation to a company, that company, any wholly­ owned subsidiary of
that company, any holding company of which that company is a wholly owned
subsidiary and any other wholly-owned subsidiary of such a holding company; •
“Hired Employees”    has the meaning ascribed to it in the Asset Purchase
Agreement;

--------------------------------------------------------------------------------

“Parties”

   means the parties to this Agreement;

“Products”

   has the meaning ascribed to it in the Asset Purchase Agreement;

“Services”

   means those services set out in the Schedule together with such other
services as may be agreed in writing from time to time by the Suppliers and the
Recipients; and

“VAT”

   means value added tax and includes any substituted or similar tax.

 

1.2 Words and expressions defined in the Asset Purchase Agreement shall, unless
they are otherwise defined herein or unless the context otherwise requires, bear
the same meanings in this Agreement

 

2. CONDITION

This Agreement is conditional upon, and shall only come into effect, upon
Closing.

 

3. PROVISION OF SERVICES

 

3.1 Subject to clause 2, in consideration of the undertaking of the Recipients
obligations hereunder, the Suppliers agree to provide, or procure the provision
of, each of the Services, on a non-exclusive basis, to the Recipients during the
term of this Agreement

 

3.2 The Recipients shall provide the Suppliers with all reasonable information
and assistance required to enable the Suppliers to provide the Services in
accordance with the terms of this Agreement

 

4. TERM

This Agreement shall come into force on the Closing Date and, unless terminated
earlier in accordance with the provisions of clause 7 below, shall expire on 31
December 2011 (the “Transition Period”).

 

5. FEES

 

5.1 In consideration for the provision of the Services by the Suppliers pursuant
to clause 3, the Recipients agree to pay fees to the Suppliers in such amounts
as are agreed between the parties from time to time.

 

5.2 The Suppliers will invoice the Recipients monthly in arrears in respect of
the amounts required to be paid by the Recipients under clause 5.1 and the
Recipients shall pay the amounts so stated within 14 days of the receipt of the
invoice together with appropriate vouchers or suitable evidence.

 

5.3 The Suppliers shall keep and maintain complete and accurate books, records
and accounts of its activities hereunder and the Services provided hereunder.
The Suppliers shall prepare and furnish to the Recipients such information and
reports regarding its activities hereunder and the Services provided hereunder
as the Recipients may reasonably request from time to time. The Recipients (and
their representatives) shall have !he right to examine, inspect and copy the
books, records and accounts of the Suppliers relating to the Services provided
hereunder at reasonable intervals during regular business hours.

 

2

--------------------------------------------------------------------------------

6. SUPPLIERS’ GROUP POLICIES

The Recipients shall comply, and shall use their reasonable endeavours to
procure that their officers, employees, agents and representatives shall comply
at all times with the policies and procedures of the Suppliers and the
Suppliers’ Group which are relevant to the receipt or use of the Services.

 

7. TERMINATION

 

7.1 This Agreement may be terminated at any time:

 

  7.1.1 by an agreement in writing signed by each of the Parties;

 

  7.1.2 by either the Suppliers or the Recipients upon breach or default by the
other.

Such termination shall be effective twenty (20) days after receipt by the
breaching party of written notice by the non-breaching party of the breach if
such breach or default is not cured within such twenty (20) days after such
receipt, provided that with respect to a breach or default of the Recipients
under clause 5, the Suppliers may terminate this Agreement if such breach or
default is not cured seven (7) Business Days after the Recipients’ receipt of
notice from Suppliers’ of such breach or default; or

 

  7.1.3 by either the Suppliers or the Recipients if (A) a trustee or receiver
is appointed for the other party, (B) a court orders that any assets of the
other party be attached, (C) the other party makes an assignment for the benefit
of creditors, or (D) a voluntary or involuntary petition or proceeding is filed
by or against the other party under any bankruptcy, reorganization, insolvency
or similar law relating to relief of creditors or debtors. Such termination
shall be effective ten (10) days after certified receipt by the other party of
notice of such termination.

 

7.2 This Agreement shall terminate at the end of the Transition Period, unless
extended by written agreement between the Parties hereto.

 

7.3 Upon termination of this Agreement all rights and obligations of the Parties
shall cease to have effect immediately except that termination shall not affect
accrued rights and obligations of the Parties under this Agreement at the date
of termination or any express obligations (or any obligations which by
implication are) of a continuing nature.

 

7.4 Termination of this Agreement will have no effect on any other agreements
between the Recipients and Suppliers except to the extent such effect is
identified and mutually and specifically agreed upon in writing between the
Parties.

 

8. GENERAL OBLIGATIONS

 

8.1 Each Supplier shall provide, or procure the provision of, the Services in
accordance with its policies, procedures and practices in effect immediately
prior to the Closing Date and in accordance with all applicable laws and, in
providing the Services, shall exercise the same degree of care and skill as it
exercises in performing similar services for itself.

 

8.2 Except as otherwise set forth herein, each Party makes no representations or
warranties, express, implied, or statutory, including but not limited to the
implied warranties of merchantability or fitness for a. particular purpose, with
respect to the services or other deliverables to be provided under this
Agreement.

 

3

--------------------------------------------------------------------------------

8.3 With respect to the Services provided under this Agreement, the Recipients
shall indemnify, defend, and hold harmless the Suppliers, as applicable, its
officers and employees from and against any and all liabilities that arise out
of, or result from, the provision of Services by the Suppliers in accordance
with this Agreement, other than liabilities arising solely from the negligence
or wilful misconduct of the Suppliers or its officers or employees.

 

8.4 The Parties will use good faith efforts to cooperate with each other in all
matters relating to the provision and receipt of the Services.

 

8.5 Nothing in this Agreement shall operate to exclude or restrict any party’s
liability for death or personal injury resulting from gross negligence or fraud
or deceit or any statutory or other liability which cannot be excluded under
applicable law.

 

9. CONFIDENTIALITY

 

9.1 Each of the Parties shall both during and at any time after the term of this
Agreement keep confidential all information which has been disclosed, supplied
or made available to it by or on behalf of the other party which by its nature
ought to be regarded as confidential and shall procure that its employees,
agents, members of its Group, sub­ contractors and sub-licensees and their
employees and agents are similarly bound in a manner satisfactory to the other
party and shall not disclose the same to any person.

 

9.2 This clause 9 shall not apply to:

 

  9.2.1 information which shall hereafter become published or otherwise
generally available to the public, except in consequence of wilful or negligent
act or omission by either party to this Agreement in contravention of the
obligations in this clause 9, and such obligations shall, as so limited, survive
termination of this Agreement;

 

  9.2.2 information which is made available to the recipient party by a third
party who is entitled to divulge such information and who is not under any
obligation of confidentiality in respect thereof to the other party; and

 

  9.2.3 information which is required to be disclosed by any applicable law or
by regulation of any recognised stock exchange, provided that the party
disclosing the information shall notify the other party of the information to be
disclosed (and of the circumstances in which the disclosure is alleged to be
required) as early as reasonably possible before such disclosure must be made
and shall take all reasonable action to avoid and limit such disclosure.

 

10. NO PARTNERSHIP OR AGENCY

Nothing in this Agreement shall constitute a partnership between the Suppliers
and the Recipients or constitute either as agent of the other for any purpose
whatsoever and neither shall have authority or power to bind the other or to
contract in the name of or create liability against the other in any way or for
any purpose save as expressly authorised in writing by the other from time to
time.

 

11. VAT

Unless stated otherwise, all amounts payable under this Agreement are exclusive
of VAT (if applicable) which shall (if appropriate) be payable in addition.

 

4

--------------------------------------------------------------------------------

12. ASSIGNMENT AND SUBCONTRACTING

 

12.1 Neither the benefit nor the burden of this Agreement shall be assigned by
either party hereto without the prior written consent of the other party.

 

12.2 The Suppliers shall be entitled from time to time to delegate to a
subsidiary or associated company the performance of any of its functions, power,
authorities, duties and directions hereunder.

 

13. NOTICES

 

13.1 Any notice given by one party to the other under this Agreement must be in
writing and may be delivered personally or by prepaid first class post and in
the case of post will be deemed to have been given two Business Days after the
date of posting.

 

13.2 Notices shall be delivered or sent to the addresses of the Parties on the
frrst page of this Agreement or to any other address notified in writing by one
party to the other for the purpose of receiving notices after the date of this
Agreement.

 

13.3 Each party may specify by notice to the other a particular individual or
office holder to whom any notices served on it are to be addressed, in which
case a notice shall not be validly given unless so addressed.

 

14. SEVERANCE

 

14.1 If any provision of this Agreement is found by any court or administrative
body of competent jurisdiction to be invalid or unenforceable, such invalidity
or unenforceability shall not affect the other provisions of this Agreement
which shall remain in full force and effect.

 

14.2 If any provision of this Agreement is so found to be invalid or
unenforceable but would cease to be invalid or unenforceable if some part of the
provision were deleted, the provision in question shall apply with such
modification as may be necessary to make it valid and enforceable.

 

15. THIRD PARTIES

A person who is not party to this Agreement shall have no rights under the
Contracts (Rights of Third Parties) Act 1999 to enforce any term of this
Agreement. This clause does not affect any right or remedy of any person which
exists or is available otherwise than pursuant to that Act.

 

16. COSTS

Each party shall bear its own costs and expenses incurred in relation to the
negotiation, preparation, execution and implementation of this Agreement and all
other documents to be completed in accordance with its provisions.

 

17. WAIVER AND CUMULATIVE REMEDIES

 

17.1 The rights and remedies provided by this Agreement may be waived only in
writing and specifically, and any failure to exercise or any delay in exercising
a right or remedy by a party shall not constitute a waiver of that right or
remedy or of any other rights or remedies. A waiver of any breach of any of the
terms of this Agreement or. of a default under this Agreement shall not
constitute a waiver of any other breach or default and shall not affect the
other terms of this Agreement.

 

5

--------------------------------------------------------------------------------

17.2 The rights and remedies provided by this Agreement are cumulative and
(unless otherwise provided in this Agreement) are not exclusive of any rights or
remedies provided at law or in equity.

 

18. VARIATION

No variation or alteration of any of the provisions of this Agreement shall be
effective unless it is in writing and signed by or on behalf of each party.

 

19. COUNTERPARTS

This Agreement may be executed in any number of counterparts each of which when
executed by one or more of the Parties shall constitute an original but all of
which shall constitute one and the same instrument.

 

20. ENTIRE AGREEMENT

 

20.1 This Agreement and the documents referred to in it constitutes the entire
agreement and understanding between the Parties in respect of the matters dealt
within it and supersedes, cancels and nullifies any previous agreement between
the Parties relating to such matters notwithstanding the terms of any previous
agreement or arrangement expressed to survive termination.

 

20.2 Each of the Parties acknowledges and agrees that in entering into this
Agreement it does not rely on, and shall have no remedy in respect of, any
statement, representation, warranty or understanding (whether negligently or
innocently made) other than as expressly set out in this Agreement. The only
remedy available to a party in respect of any such statement, representation,
warranty or understanding shall be for breach of contract under the terms of
this Agreement.

 

20.3 Nothing in this clause 20 shall operate to exclude any liability for fraud.

 

21. GOVERNING LAW AND JURISDICTION

This Agreement shall be governed and construed in all respects according to the
laws of the State of Florida and the Parties hereby irrevocably submit to the
exclusive jurisdiction of the courts located in Miami-Dade County, Florida.

IN WITNESS whereof the Parties have executed this Agreement the day and year
first above

 

6

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SCHEDULE

SERVICES

The Suppliers will provide the following Services to the Recipients on
substantially the same basis as was required to run and operate the Business
immediately prior to the Closing Date. The Parties will use their
commercially-reasonable efforts to work together to agree upon and take actions
necessary to complete the transition of the Business pursuant to the terms of
this Agreement.

 

1. General

The Suppliers shall provide such administrative and support services as are
currently provided to the Business and which are reasonably required in order to
provide the services outlined below.

 

2. Payroll Services

The Suppliers shall provide payroll services (for a period of time which shall
not exceed one payroll period) to the Recipients in respect of the Hired
Employees and for any new employees of the Recipients in accordance with the
instructions given by a Recipient or any member of its Group and shall provide
reasonable assistance to the Recipients to convert and migrate the payroll
records pertaining to the Business to the relevant payroll systems of the
Recipients.

 

3. Transfer of Accounting Records and Other Data

 

3.1 The Suppliers shall use their reasonable endeavours to assist the Recipients
with the migration of accounting records and information, and all other data and
records relating to the Business from the Suppliers’ IT systems to the
Recipients’ IT systems prior to the end of the Transition Period.

 

3.2 The Suppliers will transfer to a server provided by Recipient (to the extent
that it can be transferred in the manner envisaged) all information which is
available on Suppliers’ server relevant to the Business which would reasonably
be required by the Recipients’ Group to operate the business carried on by the
Business as it is presently conducted.

 

4. Telephone Services

The Suppliers shall provide use of its existing phone system to facilitate the
Recipients’ internal and external calls, such that phone services is provided to
the Business in the same manner as is presently available to the Business.

 

7

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EXECUTED by OPKO HEALTH, INC   )           )         acting by   )     

/s/ Steven D. Rubin

   EXECUTED by   )         OPKO INSTRUMENTATION, LLC   )         acting by   )
    

/s/ Steven D. Rubin

   EXECUTED by OPTOS INC.   )           )         acting by   )     

/s/ Christine Soden

   Christine Soden           Vice President and Chief Financial Officer       
   EXECUTED by OPTOS PLC   )           )         acting by   )     

/s/ Christine Soden

   Christine Soden           Chief Financial Officer          

 

8

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Attachment C

Retention Payments

 

53

--------------------------------------------------------------------------------

Appendix I

 

Count      lname    Fname    Title    State lac.    Mos.@ Base Salary Proposed
Retention-12 Sep 2011   1       *    *    *    Fl    *   2       *    *    *   
Fl    *   3       *    *    *    FL    *   4       *    *    *    CT    *   5   
   *    *    *    FL    *   6       *    *    *    FL    *   7       *    *    *
   FL    *   8       *    *    *    FL    *   10       *    *    *    Fl    *  
11       *    *    *    FL    *   12       *    *    *    FL    *   13       *
   *    *    Fl    *   14       *    *    *    FL    *   15       *    *    *   
Fl    *   16       *    *    *    Fl    *   18       *    *    *    Fl    *   19
      *    *    *    Fl    *   20       *    *    *    FL    *   21       *    *
   *    Fl    *   22       *    *    *    Fl    *   23       *    *    *    Fl
   *   24       *    *    *    CA    *   25       *    *    *    Fl    *   26   
   *    *    *    Fl    *   27       *    *    *    Fl    *   28       *    *   
*    FL    *   29       *    *    *    FL    *   30       *    *    *    FL    *
  31       *    *    *    FL    *   32       *    *    *    Fl    *   33       *
   *    *    FL    *   34       *    *    *    FL    *   35       *    *    *   
FL    *   36       *    *    *    FL    *   37       *    *    *    UK    *   38
      *    *    *    UK    *   39       *    *    *    UK    *   40       *    *
   *    UK    *   41       *    *    *    UK    *   42       *    *    *    UK
   *

 

= in org chart

 

= not in org chart