EXHIBIT 10.3

                    AMENDED AND RESTATED GUARANTEE AGREEMENT

                            Dated as of June 3, 2002

                                      among

                           THE GUARANTORS NAMED HEREIN

                                       and

                                  BANK ONE, NA,

                                    as Agent

                                TABLE OF CONTENTS

SECTION 1.  Guarantee.........................................................1

SECTION 2.  Guarantee Absolute................................................2

SECTION 3.  Waivers...........................................................3

SECTION 4.  Security for Guarantee............................................6

SECTION 5.  Agreement to Pay..................................................6

SECTION 6.  Representations and Warranties and Covenants......................6

SECTION 7.  Amendments, Etc...................................................7

SECTION 8. Notices, Etc.......................................................7

SECTION 9.  No Waiver; Remedies...............................................8

SECTION 10.  Right of Set-Off.................................................8

SECTION 11.  Continuing Guarantee.............................................8

SECTION 12.  Assignments......................................................8

SECTION 13.  Information......................................................9

SECTION 14.  Joinder Agreement................................................9

SECTION 15.  Counterparts.....................................................9

SECTION 16.  Severability.....................................................9

SECTION 17.  Governing Law; Submission to Jurisdiction: Venue................10

SECTION 18.  Subordination, by Guarantor.....................................10

SECTION 19.  Survival of Agreement...........................................10

SECTION 20.  Entirety........................................................11

SECTION 21.  Headings........................................................11

                                       i

         AMENDED AND RESTATED GUARANTEE AGREEMENT ("Guarantee Agreement") dated
as of June 3, 2002, among the Subsidiaries listed on Schedule 1 hereof and such
other Subsidiaries as shall become parties hereto in accordance with Section 14
hereof (such listed and other Subsidiaries being referred to herein individually
as a "Guarantor" and collectively as the "Guarantors") and BANK ONE, NA, as
Agent for the Lenders. This Guarantee Agreement amends and restates in its
entirety the Guarantee Agreement dated as of October 13, 2000 by and among the
Guarantors named therein and Agent.

         Reference is made to the Amended and Restated Credit Agreement dated as
of June 3, 2002 (as amended, modified, restated or supplemented from time to
time, the "Credit Agreement"), among Kendle International Inc. (the "Borrower"),
the several lenders from time to time party thereto (the "Lenders") and Bank
One, NA, as Agent (the "Agent"). The rules of interpretation specified in
Section 1.4 of the Credit Agreement shall be applicable to this Guarantee
Agreement. Terms used herein and not otherwise defined herein shall have the
meanings assigned to them in the Credit Agreement.

         The Lenders have respectively agreed to extend credit to the Borrower
pursuant to, and upon the terms and subject to the conditions set forth in the
Credit Agreement. The obligations of the Lenders to extend credit under the
Credit Agreement are conditioned on, among other things, the execution and
delivery by the Guarantors of a Guarantee Agreement in the form hereof. As
Subsidiaries, the Guarantors acknowledge that they will derive substantial
benefits from the extension of credit to the Borrower under the Credit
Agreement. As consideration therefor and in order to induce the Lenders to make
Loans, the Guarantors are willing to execute and deliver this Guarantee
Agreement.

         Accordingly, the Guarantors, intending to be legally bound, hereby
agree with the Agent, for the ratable benefit of the Secured Parties, as
follows:

         SECTION 1.   Guarantee. Each Guarantor unconditionally guarantees,
jointly with the other Guarantors and severally, as a primary obligor and not
merely as a surety, (a) the due and punctual payment by the Borrower of (i) the
principal of and interest (including interest accruing after the filing of a
petition initiating any proceeding referred to in Section 8.1(f) of the Credit
Agreement) on the Loans, when and as due, whether at maturity, by acceleration,
upon one or more dates set for prepayment or otherwise, and (ii) all other
monetary obligations, including indemnities and fees, costs and expenses,
whether primary, secondary, direct, contingent, fixed or otherwise (including
monetary obligations incurred during the pendency of any bankruptcy, insolvency,
receivership or other similar proceeding, regardless of whether allowed or
allowable in such proceeding), of the Credit Parties to the Secured Parties
under the Credit Agreement and the other Credit Documents, and (b) the due and
punctual performance of all covenants, agreements, obligations and liabilities
of the Credit Parties under or pursuant to the Credit Agreement and the other
Credit Documents (all the monetary and other obligations referred to in the
preceding clauses (a) and (b) being collectively called the "Guaranteed
Obligations"). Each Guarantor further agrees that the Guaranteed Obligations may
be extended or renewed, in

whole or in part, without notice to or further assent from it, and that it will
remain bound upon its guarantee notwithstanding any extension or renewal of any
Guaranteed Obligation.

         Anything contained in this Guarantee Agreement to the contrary
notwithstanding, the obligations of each Guarantor hereunder shall be limited to
a maximum aggregate amount equal to the greatest amount that would not render
such Guarantor's obligations hereunder subject to avoidance as a fraudulent
transfer or conveyance under Section 548 of Title 11 of the United States Code
or any provisions of applicable state law (collectively, the "Fraudulent
Transfer Laws"), in each case after giving effect to all other liabilities of
such Guarantor, contingent or otherwise, that are relevant under the Fraudulent
Transfer Laws (specifically excluding, however, any liabilities of such
Guarantor (a) in respect of intercompany indebtedness to the Borrower or
Affiliates of the Borrower to the extent that such indebtedness (i) would be
discharged or would be subject to a right of set-off in an amount equal to the
amount paid by such Guarantor hereunder or (ii) has been pledged to, and is
enforceable by, the Agent on behalf of the Secured Parties and (b) under any
Guarantee of Indebtedness subordinated in right of payment to the Guaranteed
Obligations which Guarantee contains a limitation as to a maximum amount similar
to that set forth is this paragraph, pursuant to which the liability of such
Guarantor hereunder is included in the liabilities taken into account in
determining such maximum amount) and after giving effect as assets to the value
(as determined under the applicable provisions of the Fraudulent Transfer Laws)
of any rights to subrogation, contribution, reimbursement, indemnity or similar
rights of such Guarantor pursuant to (i) applicable law or (ii) any agreement
providing for an equitable allocation among such Guarantor and other Affiliates
of the Borrower of obligations arising under Guarantees by such parties. In the
event that any Guarantor's liability hereunder is limited pursuant to this
paragraph to an amount that is less than the total amount of the Guaranteed
Obligations, then it is understood and agreed that the portion of the Guaranteed
Obligations for which such Guarantor is liable hereunder shall be the last
portion of the Guaranteed Obligations to be repaid.

     SECTION 2. Guarantee Absolute.

     (a) Each Guarantor guarantees that the Guaranteed Obligations will be paid
strictly in accordance with the terms of the Credit Documents, regardless of any
law, regulation or order now or hereafter in effect in any jurisdiction
affecting any of such terms or the rights of the Secured Parties with respect
thereto. The obligations of the Guarantors under this Guarantee Agreement are
independent of the Guaranteed Obligations, and a separate action or actions may
be brought and prosecuted against each Guarantor to enforce this Guarantee
Agreement, irrespective of whether any action is brought against the Borrower or
any other Guarantor or whether the Borrower or any other Guarantor is joined in
any such action or actions. This Guarantee Agreement is an absolute and
unconditional guaranty of payment when due, and not of collection, by each
Guarantor, jointly and severally with any other Guarantor of the Guaranteed
Obligations in each and every particular. The obligations of each Guarantor
hereunder are several from those of the Borrower and are primary obligations
concerning which each Guarantor is the principal

                                       2

obligor. The Secured Parties shall not be required to mitigate damages or take
any action to reduce, collect or enforce the Guaranteed Obligations.

     (b) This Guarantee Agreement shall continue to be effective or be
reinstated, as the case may be, if at any time any payment of any of the
Guaranteed Obligations is rescinded or must otherwise be returned by the Agent
or any other Secured Party upon the insolvency, bankruptcy or reorganization of
the Borrower or otherwise, all as though such payment had not been made.

     (c) The obligations of each Guarantor hereunder shall not be subject to any
reduction, limitation, impairment or termination for any reason, including the
existence of any claim, set-off or other right which any Guarantor may have at
any time against the Borrower or any Guarantor, the Agent or other Secured Party
or any other corporation or person, whether in connection herewith or any
unrelated transactions. Without limiting the generality of the foregoing, each
Guarantor's liability shall extend to all amounts that constitute part of the
Guaranteed Obligations and would be owed by the Borrower to any Secured Party
under the Credit Documents but for the fact that they are unenforceable or not
allowable due to the existence of a bankruptcy, reorganization or similar
proceeding involving the Borrower.

     SECTION 3. Waivers. Each Guarantor hereby waives presentment to,
demand of payment from and protest to the Borrower or any other Guarantor of any
of the Guaranteed Obligations, and also waives promptness, diligence, notice of
acceptance of its guarantee, any other notice with respect to any of the
Guaranteed Obligations and this Guarantee Agreement and any requirement that the
Agent or any other Secured Party protect, secure, perfect or insure any Lien or
any property subject thereto. Each Guarantor further waives any right to require
that resort be had by the Agent or any other Secured Party to any security held
for payment of the Guaranteed Obligations or to any balance of any deposit,
account or credit on the books of the Agent or any other Secured Party in favor
of the Borrower or any other person. Each Guarantor hereby consents and agrees
to each of the following to the fullest extent permitted by law, and agrees to
the fullest extent permitted by law that such Guarantor's obligations under this
Guarantee Agreement shall not be released, diminished, impaired, reduced or
adversely affected by any of the following, and waives any rights (including
rights to notice) which such Guarantor might otherwise have as a result of or in
connection with any of the following:

          (a) Any renewal, extension, modification, increase, decrease,
     alteration or rearrangement of all or any part of the Guaranteed
     Obligations or any instrument executed in connection therewith, or any
     contract or understanding with the Borrower, the Agent, the other Secured
     Parties, or any of them, or any other person, pertaining to the Guaranteed
     Obligations;

          (b) Any adjustment, indulgence, forbearance or compromise that might
     be granted or given by the Agent or any other Secured Party to the Borrower
     or any Guarantor or any person liable on the Guaranteed Obligations; or the
     failure

                                       3

     of the Agent or any other Secured Party to assert any claim or demand or to
     exercise any right or remedy against the Borrower or any Guarantor under
     the provisions of any Credit Document or otherwise; or any rescission,
     waiver, amendment or modification of, or any release from any of the terms
     or provisions of, any Credit Document, any guarantee or any other
     agreement, including with respect to any other Guarantor under this
     Guarantee Agreement;

          (c) The insolvency, bankruptcy arrangement, adjustment, composition,
     liquidation, disability, dissolution or lack of power of the Borrower or
     any Guarantor or any other person at any time liable for the payment of all
     or part of the Guaranteed Obligations; or any dissolution of the Borrower
     or any Guarantor, or any change, restructuring or termination of the
     corporate structure or existence of the Borrower or any Guarantor, or any
     sale, lease or transfer of any or all of the assets of the Borrower or any
     Guarantor, or any change in the shareholders, partners, or members of the
     Borrower or any Guarantor; or any default, failure or delay, willful or
     otherwise, in the performance of the Guaranteed Obligations;

          (d) The invalidity, illegality or unenforceability of all or any part
     of the Guaranteed Obligations, or any document or agreement executed in
     connection with the Guaranteed Obligations, for any reason whatsoever,
     including the fact that the Guaranteed Obligations, or any part thereof,
     exceed the amount permitted by law, the act of creating the Guaranteed
     Obligations or any part thereof is ultra vires, the officers or
     representatives executing the documents or otherwise creating the
     Guaranteed Obligations acted in excess of their authority, the Guaranteed
     Obligations violate applicable usury laws, the Borrower has valid defenses,
     claims or offsets (whether at law, in equity or by agreement) which render
     the Guaranteed Obligations wholly or partially uncollectible from the
     Borrower, the creation, performance or repayment of the Guaranteed
     Obligations (or the execution, delivery and performance of any document or
     instrument representing part of the Guaranteed Obligations or executed in
     connection with the Guaranteed Obligations or given to secure the repayment
     of the Guaranteed Obligations) is illegal, uncollectible, legally
     impossible or unenforceable, or the documents or instruments pertaining to
     the Guaranteed Obligations have been forged or otherwise are irregular or
     not genuine or authentic;

          (e) Any full or partial release of the liability of the Borrower on
     the Guaranteed Obligations or any part thereof, of any co-guarantors, or of
     any other person now or hereafter liable, whether directly or indirectly,
     jointly, severally, or jointly and severally, to pay, perform, guarantee or
     assure the payment of the Guaranteed Obligations or any part thereof, it
     being recognized, acknowledged and agreed by each Guarantor that such
     Guarantor may be required to pay the Guaranteed Obligations in full without
     assistance or support of any other person, and such Guarantor has not been
     induced to enter into this Guarantee Agreement on the basis of a
     contemplation, belief, understanding or agreement that any parties other

                                       4

     than the Borrower will be liable to perform the Guaranteed Obligations, or
     that the Secured Parties will look to other parties to perform the
     Guaranteed Obligations;

          (f) The taking or accepting of any other security, collateral or
     guaranty, or other assurance of payment. for all or any part of the
     Guaranteed Obligations;

          (g) Any release, surrender, exchange, subordination, deterioration,
     waste, loss or impairment (including negligent, unreasonable or
     unjustifiable impairment) of any collateral, property or security, at any
     time existing in connection with, or assuring or securing payment of, all
     or any part of the Guaranteed Obligations;

          (h) The failure of the Agent, any other Secured Party or any other
     person to exercise diligence or reasonable care in the preservation,
     protection, enforcement, sale or other handling or treatment of all or any
     part of such collateral, property or security;

          (i) The fact that any collateral, security, security interest or lien
     contemplated or intended to be given, created or granted as security for
     the repayment of the Guaranteed Obligations shall not be properly perfected
     or created, or shall prove to be unenforceable or subordinate to any other
     security interest or lien, it being recognized and agreed by each Guarantor
     that such Guarantor is not entering into this Guarantee Agreement in
     reliance on, or in contemplation of the benefits of, the validity,
     enforceability, collectibility or value of any of the Collateral;

          (j) Any payment by the Borrower to the Agent or any other Secured
     Party being held to constitute a preference under Title 11 of the United
     States Code or any similar Federal or state law, or for any reason the
     Agent or any other Secured Party being required to refund such payment or
     pay such amount to the Borrower or someone else;

          (k) Any other action taken or omitted to be taken with respect to the
     Guaranteed Obligations, or the security and collateral therefor, whether or
     not such action or omission prejudice any Guarantor or increases the
     likelihood that any Guarantor will be required to pay the Guaranteed
     Obligations pursuant to the terms hereof, it being the unambiguous and
     unequivocal intention of each Guarantor that such Guarantor shall be
     obligated to pay the Guaranteed Obligations when due, notwithstanding any
     occurrence, circumstance, event, action or omission whatsoever, whether or
     not contemplated, and whether or not otherwise or particularly described
     herein, except for the full and final payment and satisfaction of the
     Guaranteed Obligations in cash;

          (l) The fact that all or any of the Guaranteed Obligations cease to
     exist by operation of law, including by way of a discharge, limitation or
     tolling thereof under applicable bankruptcy laws; or

          (m) Any other circumstance (including any statute of limitations) that
     might in any manner or to any extent otherwise constitute a defense
     available to, vary the risk of,

                                       5

     or operate as a discharge of, the Borrower or any Guarantor as a matter of
     law or equity.

All waivers herein contained shall be without prejudice to the Agent at its
option to proceed against the Borrower, any Guarantor or any other person,
whether by separate action or by joinder.

     SECTION 4. Security for Guarantee. Each of the Guarantors authorizes the
Agent, in accordance with the terms and subject to the conditions set forth in
the Collateral Documents, (a) to take and hold security for the payment of this
Guarantee Agreement and the Guaranteed Obligations and to exchange, enforce,
waive and release any such security, (b) to apply such security and direct the
order or manner of sale thereof as the Agent in its sole discretion may
determine and (c) to release or substitute any one or more endorsees, other
guarantors or other obligors. The Agent may, at its election, in accordance with
the terms and subject to the conditions set forth in the Collateral Documents,
foreclose on any security held by it by one or more judicial or nonjudicial
sales, or exercise any other right or remedy available to it against the
Borrower or any of the Guarantors, or any security, without affecting or
impairing in any way the liability of any of the Guarantors hereunder, except to
the extent the Guaranteed Obligations have been indefeasibly paid in full in
cash.

     SECTION 5. Agreement to Pay. In furtherance of the foregoing and not in
limitation of any other right that the Agent or any other Secured Party has at
law or in equity against any Guarantor by virtue hereof, upon the failure of the
Borrower or any other Credit Party to pay any Guaranteed Obligation when and as
the same shall become due, whether at maturity, by acceleration, after notice of
prepayment or otherwise, each Guarantor hereby promises to and will forthwith
pay, or cause to be paid, to the Agent or such other Secured Party as designated
thereby in cash the amount of such unpaid Guaranteed Obligations. Upon payment
by any Guarantor of any sums to the Agent or any Secured Party as provided
above, all rights of such Guarantor against the Borrower arising as a result
thereof by way of right of subrogation, contribution, reimbursement, indemnity
or otherwise shall in all respects be subordinate and junior in right of payment
to the prior indefeasible payment in full of cash of all the Guaranteed
Obligations. If any amount shall erroneously be paid to any Guarantor on account
of such subrogation, contribution, reimbursement, indemnity or similar right,
such amount shall be held in trust for the benefit of the Secured Parties and
shall forthwith be turned over to the Agent in the exact form received by such
Guarantor (duly endorsed by such Guarantor to the Agent, if required) to be
credited against the payment of the Guaranteed Obligations, whether matured or
unmatured, in accordance with the terms of the Credit Documents.

     SECTION 6. Representations and Warranties and Covenants. Each Guarantor
hereby represents, warrants and covenants as follows:

          (a) All representations and warranties contained in the Credit
     Agreement that relate to such Guarantor are true and correct in all
     material respects.

                                       6

          (b) Such Guarantor agrees to comply with each of the covenants
     contained in the Credit Agreement that imposes or purports to impose,
     through agreements with the Borrower, restrictions or obligations on such
     Guarantor.

          (c) Such Guarantor acknowledges that any default in the due observance
     or performance by such Guarantor of any covenant, condition or agreement
     contained herein shall constitute an Event of Default as provided in
     Section 8 of the Credit Agreement.

          (d) There are no conditions precedent to the effectiveness of this
     Guarantee Agreement that have not been satisfied or waived.

          (e) Such Guarantor has, independently and without reliance upon the
     Agent or any other Secured Party and based on such documents and
     information as it has deemed appropriate, made its own credit analysis and
     decision to enter into this Guarantee Agreement. Such Guarantor has
     investigated fully the benefits and advantages which will be derived by it
     from execution of this Guarantee Agreement, and the Board of Directors of
     such Guarantor has decided that a direct or an indirect benefit will accrue
     to such Guarantor by reason of the execution of this Guarantee Agreement.

          (f) (i) This Guarantee Agreement is not given with actual intent to
     hinder, delay or defraud any person to which such Guarantor is or will
     become, on or after the date hereof, indebted; (ii) such Guarantor has
     received at least a reasonably equivalent value in exchange for the giving
     of this Guarantee Agreement; (iii) such Guarantor is not insolvent on the
     date hereof and will not become insolvent as a result of the giving of this
     Guarantee Agreement; (iv) such Guarantor is not engaged in a business or
     transaction, nor is about to engage in a business or transaction, for which
     any property remaining with such Guarantor constitutes an unreasonably
     small amount of capital; and (v) such Guarantor does not intend to incur
     debts that will be beyond such Guarantor's ability to pay as such debts
     mature.

     SECTION 7. Amendments, Etc. No amendment, modification or waiver of any
provision of this Guarantee Agreement and no consent to any departure by any
Guarantor therefrom shall in any event be effective unless the same shall be in
writing and shall be executed and delivered in accordance with Section 10.6 of
the Credit Agreement, and then such amendment, modification, waiver or consent
shall be effective only in the specific instance and for the specific purpose
for which given; provided, that, this Guarantee Agreement may be amended,
modified or waived with respect to any Guarantor, including by releasing any
Guarantor hereunder, without the approval of any other Guarantor and without
affecting the obligations of any other Guarantor hereunder.

     SECTION 8. Notices, Etc. Except as otherwise expressly provided herein, all
notices and other communications shall have been duly given and shall be
effective (a) when delivered, (b) when transmitted via telecopy (or other
facsimile device) to the number,

                                       7

with telephonic confirmation of receipt, in the case of the Agent, set forth in
Section 10.1 of the Credit Agreement and in the case of the Guarantors, set
forth on the signature pages hereof, (c) on the Business Day following the day
on which the same has been delivered prepaid to a reputable national overnight
air courier service, or (d) on the fifth Business Day following the day on which
the same is sent by certified or registered mail, postage prepaid, in each case
to the respective parties at the address, in the case of the Agent, set forth in
Section 10.1 of the Credit Agreement, and, in the case of the Guarantors, set
forth on the signature pages hereof, or at such other address as such party may
specify by written notice to the other parties hereto.

     SECTION 9. No Waiver; Remedies. No failure on the part of the Agent or any
other Secured Party to exercise, and no delay in exercising, any right, power or
remedy hereunder shall operate as a waiver thereof, nor shall any single or
partial exercise of any such right, power or remedy by the Agent or any other
Secured Party preclude any other or further exercise thereof or the exercise of
any other right, power or remedy. All remedies hereunder and under the other
Credit Documents are cumulative and are not exclusive of any other remedies
provided by law.

     SECTION 10. Right of Set-Off. If an Event of Default shall have occurred
and be continuing, each Secured Party is hereby authorized at any time and from
time to time, to the fullest extent permitted by law, to set off and apply any
and all deposits (general or special, time or demand, provisional or final) at
any time held and other indebtedness at any time owing by such Secured Party to
or for the credit or the account of any Guarantor against any and all the
obligations of such Guarantor then existing under this Guarantee Agreement and
the other Credit Documents, irrespective of whether or not such Secured Party
shall have made any demand under this Guarantee Agreement or such other Credit
Document and although such obligations may be unmatured. The rights of each
Secured Party under this Section 10 are in addition to other rights and remedies
(including other rights of setoff) which such Secured Party may have.

     SECTION 11. Continuing Guarantee. This Guarantee Agreement is a continuing
Guarantee and shall survive and remain in full force and effect until the
Guaranteed Obligations and all other amounts payable under this Guarantee
Agreement have been indefeasibly paid in full in cash, the Commitments have been
terminated, all Letters of Credit have been cancelled or have expired and shall
be reinstated to the extent provided in Section 2(b). A Guarantor shall be
immediately and irrevocably released from its guarantee hereunder in the event
that all the capital stock of such Guarantor shall be sold, transferred or
otherwise disposed of by the Borrower or a Subsidiary that shall own such stock
to a person that is not the Borrower or an Affiliate of the Borrower; provided,
that, such sale, transfer or disposition shall be permitted pursuant to the
Credit Agreement and the other Credit Documents or any amendment, modification
or waiver thereof granted in accordance with the terms thereof.

     SECTION 12. Assignments. This Guarantee Agreement and the terms, covenants
and conditions hereof shall be binding upon each Guarantor and its successors
and shall

                                       8

inure to the benefit of the Agent, the other Secured Parties and their
respective successors and assigns. Upon the assignment by any Lender of all or
any portion of its rights and obligations under the Credit Agreement (including
all or any portion of its Commitment, the Loans owing to it and the Note or
Notes held by it) to any other person, such other person shall thereupon become
vested with all the benefits in respect thereof granted to such Lender herein or
otherwise. None of the Guarantors shall be permitted to assign, transfer or
delegate any of its rights or obligations under this Guarantee Agreement without
the prior written consent of the Agent and each Lender (and any such purported
assignment, transfer or delegation without such consent shall be void).

     SECTION 13. Information. Each of the Guarantors assumes all responsibility
for being and keeping itself informed of the Borrower's financial condition and
assets, and of all other circumstances bearing upon the risk of nonpayment of
the Guaranteed Obligations and the nature, scope and extent of the risks that
such Guarantor assumes and incurs hereunder, and agrees that none of the Agent
or the other Secured Parties will have any duty to advise any of the Guarantors
of information known to it or any of them regarding such circumstances or risks.

     SECTION 14. Joinder Agreement. Upon execution and delivery by the Agent and
a Subsidiary of a Joinder Agreement substantially in the form of Exhibit J to
the Credit Agreement, such Subsidiary shall become a Guarantor hereunder with
the same force and effect as if originally named as a Guarantor herein. The
execution and delivery of any such instrument shall not require the consent of
any other Guarantor hereunder. The rights and obligations of each Guarantor
hereunder shall remain in full force and effect notwithstanding the addition of
any new Guarantor as a party to this Guarantee Agreement.

     SECTION 15. Counterparts. This Guarantee Agreement may be executed in any
number of counterparts, each of which when so executed and delivered shall be an
original, but all of which shall constitute one and the same instrument. It
shall not be necessary in making proof of this Guarantee Agreement to produce or
account for more than one such counterpart for each of the parties hereto.
Delivery by facsimile by any of the parties hereto of an executed counterpart of
this Guarantee Agreement shall be as effective as an original executed
counterpart hereof and shall be deemed a representation that an original
executed counterpart hereof will be delivered, but the failure to deliver a
manually executed counterpart shall not affect the validity, enforceability, or
binding effect of this Guarantee Agreement.

     SECTION 16. Severability. If any provision of this Guarantee Agreement or
any of the Credit Documents is determined to be illegal, invalid or
unenforceable, such provision shall be fully severable and the remaining
provisions shall remain in full force and effect and shall be construed without
giving effect to the illegal, invalid or unenforceable provisions. The parties
hereto shall endeavor in good-faith negotiations to replace the invalid, illegal
or unenforceable provisions with valid provisions the economic effect of which
comes as close as possible to that of the invalid, illegal or unenforceable
provisions.

                                       9

     SECTION 17. Governing Law; Submission to Jurisdiction: Venue.

     (a) THIS GUARANTEE AGREEMENT SHALL BE CONSTRUED IN ACCORDANCE WITH AND
GOVERNED BY THE LAWS OF THE STATE OF OHIO WITHOUT REGARD TO PRINCIPLES OF
CONFLICTS OF LAWS. Any legal action or proceeding with respect to this Guarantee
Agreement may be brought in the courts of the State of Ohio in Hamilton County,
or of the United States for the Southern District, Western Division of Ohio,
and, by execution and delivery of this Guarantee Agreement, each Guarantor
hereby irrevocably accepts for itself and in respect of its property, generally
and unconditionally, the nonexclusive jurisdiction of such courts. Each
Guarantor further irrevocably consents to the service of process out of any of
the aforementioned courts in any such action or proceeding by the mailing of
copies thereof by registered or certified mail, postage prepaid, to it at the
address set forth for notices pursuant to Section 8, such service to become
effective five (5) days after such mailing. Nothing herein shall affect the
right of the Agent to serve process in any other manner permitted by law or to
commence legal proceedings or to otherwise proceed against any Credit Party in
any other jurisdiction.

     (b) Each Guarantor hereby irrevocably waives any objection which it may now
or hereafter have to the laying of venue of any of the aforesaid actions or
proceedings arising out of or in connection with this Guarantee Agreement
brought in the courts referred to in subsection (a) above and hereby further
irrevocably waives and agrees not to plead or claim in any such court that any
such action or proceeding brought in any such court has been brought in an
inconvenient forum.

     (c) To the extent permitted by law, each Guarantor hereby irrevocably
waives all right to trial by jury in any action, proceeding or counterclaim
arising out of or relating to this Guarantee Agreement and the other Credit
Documents or the transactions contemplated hereby or thereby.

     SECTION 18. Subordination, by Guarantor. Each Guarantor hereby subordinates
in right of payment all indebtedness of the Borrower or any other Guarantor
owing to it, whether originally contracted with such Guarantor or acquired by
such Guarantor by assignment, transfer or otherwise, whether now owed or
hereafter arising, whether for principal, interest, fees, expenses or otherwise,
together with all renewals, extensions, increases or rearrangements thereof, to
the prior indefeasible payment in full in cash of the Guaranteed Obligations,
whether now owed or hereafter arising, whether for principal, interest
(including interest accruing during the pendency of any bankruptcy, insolvency,
receivership or other similar proceeding, regardless of whether allowed or
allowable in such proceeding), fees, expenses or otherwise, together with all
renewals, extensions, increases or rearrangements thereof.

     SECTION 19. Survival of Agreement. All covenants, agreements,
representations and warranties made by each Guarantor herein shall be considered
to have been relied upon by the Agent and the other Secured Parties and shall
survive the making by the Lenders of the Loans and the execution and delivery to
the Lenders of the Notes

                                       10

evidencing such Loans, regardless of any investigation made by the Lenders or
the Agent or on their behalf, and shall continue in full force and effect until
the Guaranteed Obligations and any other amounts payable under this Guarantee
Agreement or any other Credit Document have been indefensibly paid in full in
cash and the Commitments have been terminated.

     SECTION 20. Entirety. This Guarantee Agreement, the other Credit Documents
and the Lender Hedging Agreements, if any, represent the entire agreement of the
parties hereto and thereto regarding the subject matter hereof and thereof and
supersede all prior agreements and understandings, oral or written, if any
(including any commitment letters or correspondence) relating to such subject
matters. Nothing in this Guarantee Agreement or any other Credit Document,
expressed or implied, is intended to confer upon any party (other than the
parties hereto and thereto and the other Secured Parties) any rights, remedies,
obligations or liabilities under or by reason of this Guarantee Agreement and
the other Credit Documents.

     SECTION 21. Headings. The headings of the sections and subsections hereof
are provided for convenience only and shall not in any way affect the meaning or
construction of any provision of this Guarantee Agreement.

                           [SIGNATURE PAGE TO FOLLOW]

     IN WITNESS WHEREOF, each party hereto has caused this Guarantee Agreement
to be duly executed, attested and delivered by its officers thereunto duly
authorized as of the date first above written.

KENDLE DELAWARE INC., as Guarantor        KENDLE U.K. INC., as Guarantor

By:_______________________________        By:______________________________
     Timothy M. Mooney                         Timothy M. Mooney
     Vice President                            Vice President

Address:   1200 Carew Tower                    Address:       1200 Carew Tower
           441 Vine Street                                    441 Vine Street
           Cincinnati, Ohio 45202                             Cincinnati, Ohio 45202
Telecopy:  (513) 562-1789                      Telecopy:      (513) 562-1789

HEALTH CARE COMMUNICATIONS INC.,           ACER/EXCEL, INC., as Guarantor
as Guarantor

By:_______________________________         By:______________________________
     Timothy M. Mooney                          Timothy M. Mooney
     Vice President                             Vice President

Address:   1200 Carew Tower                Address:       1200 Carew Tower
           441 Vine Street                                441 Vine Street
           Cincinnati, Ohio 45202                         Cincinnati, Ohio 45202
Telecopy:  (513) 562-1789                  Telecopy:      (513) 562-1789

KENDLE HCC LP, as Guarantor                KENDLE NEW JERSEY, LP, as Guarantor
By: Health Care Communications Inc.        By: Health Care Communications Inc.
Its General Partner                        Its General Partner

By:________________________________        By:_______________________________
     Timothy M. Mooney                          Timothy M. Mooney
     Vice President                             Vice President

Address:   1200 Carew Tower                Address:       1200 Carew Tower
           441 Vine Street                                441 Vine Street
           Cincinnati, Ohio 45202                         Cincinnati, Ohio 45202
Telecopy:  (513) 562-1789                  Telecopy:      (513) 562-1789

KENDLE INTERNATIONAL CPU LLC               AAC CONSULTING GROUP, INC.

By:_______________________________         By:_______________________________
Its:______________________________         Its:______________________________

Address: 763 Chestnut Ridge                Address: 7361 Calhoun Place
         Morgantown, West Virginia 26505            Suite 500
                                                    Rockville, Maryland  20855

                                           BANK ONE, NA, as Agent

                                           By:______________________________
                                                 Richard B. Kuertz
                                                 First Vice Pesident

                                           Address:  Bank One Towers
                                                     8044 Montgomery Road
                                                     P.O. Box 365800
                                                     Cincinnati, Ohio 45236-5800
                                           Telecopy: (513) 985-5030