Exhibit 10.1
CHIEF EXECUTIVE OFFICER EMPLOYMENT AGREEMENT
     This Chief Executive Officer Employment Agreement (“Agreement”) is entered
into as of March 15, 2006 by and between Deirdre Y. Gillespie, M.D.
(“Executive”) and La Jolla Pharmaceutical Company, a Delaware corporation (the
“Company”).
     WHEREAS, the Company desires to employ Executive to provide personal
services to the Company, and wishes to provide Executive with certain
compensation and benefits in return for her services; and
     WHEREAS, Executive wishes to be employed by the Company and provide
personal services to the Company in return for certain compensation and
benefits.
     NOW, THEREFORE, in consideration of the mutual promises and covenants
contained herein, it is hereby agreed by and between the parties hereto as
follows:
     1. Employment by the Company.
          1.1 Title and Responsibilities. Subject to terms set forth herein, the
Company agrees to employ Executive in the position of president and chief
executive officer and Executive hereby accepts such employment effective as of
the date hereof (the “Effective Date”). During her employment with the Company,
Executive will devote her best efforts and substantially all of her business
time and attention (except for vacation periods as set forth herein and
reasonable periods of illness or other incapacity permitted by the Company’s
general employment policies) to the business of the Company.
          1.2 Executive Position. Executive will continue to serve in an
executive capacity and shall perform such duties as are customarily associated
with her title, consistent with the bylaws of the Company and as reasonably
required by the Board of Directors (the “Board”) of the Company.
          1.3 Company Employment Policies. The employment relationship between
the parties shall also be governed by the general employment policies and
practices of the Company, including those relating to protection of confidential
information and assignment of inventions, except that if the terms of this
Agreement differ from or are in conflict with the Company’s general employment
policies or practices, this Agreement shall control.
          1.4 Board of Directors. On the Effective Date, Executive shall be
appointed as a member of the Company’s Board of Directors to serve until the
next annual meeting of stockholders. Thereafter, she will stand for election
with the other directors at the annual meeting of stockholders.
     2. Compensation.
          2.1 Salary. Executive shall receive for services to be rendered
hereunder an annualized base salary of $375,000, payable on a biweekly basis in
accordance with the normal payroll practices of the Company (including
deductions, withholdings and collections as required

 

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by law). Executive will be considered for annual increases in base salary in
accordance with Company policy and subject to review and approval by the
Compensation Committee of the Board (the “Compensation Committee”).
          2.2 Signing Payment. As promptly as practicable after the Effective
Date, in consideration for Executive commencing her employment with the Company
on the date hereof, the Company will make a one-time payment to Executive of
$50,000 in cash.
          2.3 Bonus. Executive shall be eligible to participate in the Company’s
executive level bonus plan throughout the duration of Executive’s employment
with the Company.
               (a) Executive’s Performance. The amount of Executive’s bonus will
depend upon Executive’s and the Company’s performance with respect to the goals
to be established annually by the Compensation Committee.
               (b) Determination of Bonus. The amount of Executive’s bonus will
be determined after the close of the Company’s fiscal year. To be eligible to
receive a bonus, Executive must remain in employment with the Company throughout
the entire fiscal year. Notwithstanding the foregoing, but subject to
Section 2.3(c) below, in the event that Executive is terminated without Cause,
as a result of a Constructive Termination or in connection with a Change in
Control, the amount of Executive’s bonus, if any, will be determined after the
occurrence of such event and will be paid to Executive promptly thereafter. In
the case of a Change in Control, the Board agrees to consider whether to pay
Executive a bonus.
               (c) No Guaranteed Bonus. Notwithstanding the foregoing, no bonus
is guaranteed to Executive. Any bonus is subject to the approval of the Board,
which retains the authority to review, grant, deny or revise any bonus in its
sole discretion.
               (d) Target Bonus. The target bonus for Executive shall be forty
percent (40%) of her base salary.
               (e) Withholding. Any bonus paid to Executive shall be subject to
such withholdings as may be required by law.
          2.4 Stock Options. On the Effective Date, the Company will grant
Executive options to purchase 800,000 shares of common stock of the Company (the
“Options”) pursuant to the terms and subject to the conditions set forth in the
La Jolla Pharmaceutical Company 2004 Equity Incentive Plan (the “Plan”). 200,000
of the Options will vest on the first anniversary of the Effective Date.
Thereafter, 1/36th of the remaining 600,000 Options will vest on the last day of
each month until all options are vested. The exercise price of the Options shall
be the Fair Market Value (as defined in the Plan) of the Company’s common stock
on the Effective Date. With respect to the Options, the Company agrees to issue
as many ISOs as possible, with the remainder of the Options being non-qualified
stock options.
          2.5 Standard Company Benefits and Vacation. Executive shall be
entitled to those benefits provided to the Company’s executives generally,
including healthcare benefits, and

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for which she is eligible pursuant to the terms and conditions of the relevant
plans. Executive shall be entitled to three weeks of paid vacation per year.
          2.6 Business Expenses. The Company shall promptly reimburse Executive
for all reasonable and necessary business expenses incurred by Executive in
connection with the business of the Company and the performance of her duties
under this Agreement, subject to Executive providing the Company with reasonable
documentation thereof.
          2.7 Moving Expense Reimbursement; Temporary housing.
               (a) The Company agrees to pay Executive $30,000 for, among other
matters, expenses incurred by Executive in relocating to the San Diego area.
               (b) The Company will reimburse Executive for expenses actually
and reasonably incurred by Executive for temporary housing in the San Diego area
for a period of six months following the Effective Date or until such time as
the Executive obtains permanent housing, whichever is earlier, and so long as
Executive is employed by the Company. Executive agrees to notify the Chairman of
the Board regarding the approximate amount of the temporary housing expenses in
advance of incurring such expenses so that the Chairman may confirm that the
temporary housing expenses to reimbursed by the Company are reasonable.
               (c) In the event that Executive has entered into an agreement to
sell her current primary residence in Boston, Massachusetts on or prior to the
first anniversary of the Effective Date, and so long as Executive is employed by
the Company at the time of the sale, the Company will reimburse Executive for
the costs actually and reasonably incurred by Executive in connection with
selling such residence up to $50,000.
     3. Confidential Information, Rights and Duties.
          3.1 Agreement.
               (a) Confidential Information.
                    (i) Executive specifically agrees that she shall not at any
time, either during or subsequent to the term of her employment with the
Company, in any fashion, form or manner, either directly or indirectly, unless
expressly consented to in writing by an executive officer of the Company, use,
divulge, disclose or communicate to any person or entity any confidential
information of any kind, nature or description concerning any matters affecting
or relating to the business of the Company. The parties to this Agreement hereby
stipulate that, as between them, the above information and items are important,
material and confidential trade secrets that affect the successful conduct of
the Company’s business and its goodwill, and that any breach of any term of this
section is a material breach of this Agreement. All equipment, notebooks,
documents, memoranda, reports, files, samples, books, correspondence, lists or
other written and graphic records, and the like, including tangible or
intangible computer programs, records and data, affecting or relating to the
business of the Company, which the Executive might prepare, use, construct,
observe, posses or control, shall be and shall remain the Company’s sole
property.

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                    (ii) For purposes of this Agreement, the term “confidential
information” shall not include any information that: (A) has been made public by
the Company (other than by acts or omissions of Executive in violation of this
Agreement or other obligation of confidentiality); (B) is developed by Executive
independently of any information the Executive learns in the course of
fulfilling her duties hereunder; or (C) Executive is legally compelled to
disclose; provided that (1) Executive is advised by written opinion of the
Executive’s counsel, who shall be reasonably satisfactory to the Company, that
she is legally required to disclose such information and (2) Executive notifies
the Company of such proposed disclosure as far in advance of its disclosure as
is practicable and uses her best efforts to obtain assurances that confidential
treatment will be accorded to such information.
               (b) Non-Interference. Any wrongful interference with the
Company’s business, property, confidential information, trade secrets, clients,
customers, employees or independent contractors by Executive or any of
Executive’s agents during or after the term of Executive’s employment shall be
treated and acknowledged by the parties as a material breach of this Agreement.
If such interference occurs at a time that Executive is employed by the Company,
such interference shall be grounds for the Company to terminate Executive for
Cause.
          3.2 Remedies. Executive’s duties under this Section 3 shall survive
termination of Executive’s employment with the Company. Executive acknowledges
that a remedy at law for any breach or threatened breach by Executive of the
provisions of this Section 3 would be inadequate, and Executive therefore agrees
that the Company shall be entitled to injunctive relief in case of any such
breach or threatened breach.
     4. Outside Activities.
          4.1 Activities. Except as set forth on Exhibit A hereto or with the
prior written consent of the Board, Executive will not during her employment
with the Company undertake or engage in any other employment, occupation or
business enterprise (other than enterprises in which Executive is a passive
investor; provided that such passive investment is consistent with this terms of
this Agreement, including this Section 4). Notwithstanding the foregoing,
Executive may engage in civic and not-for-profit activities so long as such
activities do not materially interfere with the performance of her duties
hereunder and are otherwise consistent with this Section 4.
          4.2 Investments and Interests. Executive agrees not to acquire, assume
or participate in, directly or indirectly, any material position, investment or
interest known by her to be adverse or antagonistic to the Company, its business
or prospects, financial or otherwise.
          4.3 Non-Competition.
               (a) During her employment by the Company, except on behalf of the
Company, Executive will not directly or indirectly, whether as an officer,
director, stockholder, partner, proprietor, associate, representative,
consultant, or in any capacity whatsoever engage in, become financially
interested in, be employed by or have any business connection with any other
person, corporation, firm, partnership or other entity whatsoever which were
known by her to compete directly with the Company, throughout the world, in any
line of business engaged in (or planned to be engaged in) by the Company.

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               (b) Notwithstanding the foregoing, nothing in this Agreement
shall prevent Executive from owning for passive investment purposes less than 1%
of the publicly traded common equity securities of any company engaged in the
business of the Company (so long as Executive has no power to manage, operate,
advise, consult with or control the competing enterprise and no power, alone or
in conjunction with other affiliated parties, to select a director, manager,
general partner, or similar governing official of the competing enterprise other
than in connection with the normal and customary voting powers afforded
Executive in connection with any permissible equity ownership).
     5. Termination Of Employment.
          5.1 Termination With or Without Cause.
               (a) At-Will Employment. Executive’s relationship with the Company
is at-will. The Company shall have the right to terminate Executive’s employment
with the Company at any time with or without Cause and with or without notice.
               (b) Definition of Cause. For purposes of this Agreement, “Cause”
is defined as the occurrence of one or more of the following: (i) Executive is
convicted of or pleads guilty or nolo contendere to a felony or any crime
involving moral turpitude; (ii) Executive breaches this Agreement or any
Agreement entered into with the Company in a manner that materially and
adversely affects the Company; (iii) willful misconduct which materially and
adversely impacts the Company; or (iv) Executive fails, after receipt of written
notice and after receiving a period of at least 10 business days following such
notice, to follow a legal direction of the Board; provided however, that if it
is not possible to follow such direction within such 10 business day period,
then Cause, in this case, shall mean the failure of Executive to follow a legal
direction of the Board as soon as reasonably practicable after the end of such
10 business day period.
               (c) Termination for Cause. If Executive is terminated with Cause,
the Company shall pay Executive the compensation and benefits otherwise payable
to Executive under Section 2.1 through the date of termination. Executive’s
rights under the Company’s benefit plans of general application shall be
determined under the provisions of those plans. All other compensation from and
after such termination shall cease (except for those benefits that must be
continued pursuant to applicable law or by the terms of such benefit plans), and
Executive shall not be entitled to any severance pay or other payment or
compensation whatsoever upon such termination.
          5.2 Voluntary Termination; Death or Disability.
               (a) Voluntary Termination. Executive may voluntarily terminate
her employment with the Company at any time, after which no further compensation
will be paid to Executive, except as specifically set forth herein.

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               (b) Death or Disability. The Executive’s employment under this
Agreement shall terminate immediately and without notice by the Company upon the
death or disability of the Executive. In the event of Executive’s termination
due to death or disability, she will not be entitled to severance pay, pay in
lieu of notice or any other such compensation. For purposes of this Agreement,
Executive will be deemed to have a disability if she becomes physically or
mentally incapacitated or disabled or otherwise unable to fully discharge her
duties hereunder for a period of 60 consecutive calendar days or for 120 days in
any 360-day period.
               (c) No Severance Pay. In the event of Executive’s death or
disability or if Executive voluntarily terminates her employment other than due
to a Constructive Termination, she will not be entitled to severance pay, pay in
lieu of notice or any other such compensation.
               (d) Definition of Constructive Termination. For purposes of this
Agreement, “Constructive Termination” shall mean any one of the following events
which occurs on or after the Effective Date of this Agreement: (i) a material
reduction in Executive’s duties as an officer of the Company or a reduction in
Executive’s title(s) as an officer of the Company; (ii) a relocation of
Executive’s office to a location outside of San Diego County, California;
(iii) any material breach by the Company of its obligations under this
Agreement; or (iv) any failure by the Company to obtain the assumption of this
Agreement by any successor or assign of the Company.
          5.3 Severance Benefits.
               (a) 90-Day Severance Payment. In the event the Company terminates
Executive’s employment without Cause or if Executive terminates her employment
due to a Constructive Termination on or prior to the 90th day after the
Effective Date (the “90th Day”), and provided that Executive timely executes and
delivers a Release Agreement (as defined in Section 8) to the Company, then
Executive shall be entitled to a severance payment equal to $50,000 (the “90-Day
Severance Payment”). The 90-Day Severance Payment shall be made in lump sum
promptly following the effectiveness of the Release Agreement.
               (b) Severance Payment. In the event the Company terminates
Executive’s employment without Cause or if Executive terminates her employment
due to a Constructive Termination after the 90th Day, and provided that
Executive timely executes and delivers a Release Agreement to the Company,
Executive shall be entitled to a lump sum severance payment equal to one times
Executive’s then current annual base salary (the “Standard Severance Payment”).
As soon as reasonable practicable after the one year anniversary of the
Effective Date, the Board agrees to review Executive’s performance. If the Board
determines, in its reasonable discretion, that Executive has performed in a
satisfactory manner, then the Standard Severance Payment shall increase to one
and one-half times Executive’s annual base salary at the time of the event
resulting in the payment of the severance payment.
               (c) Stock Options.
                    (i) Before the 90th Day. If Executive’s employment ceases
for any reason on or before the 90th Day, then all Options shall immediately
terminate.

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                    (ii) After the 90th Day.
                         (A) If the Company terminates Executive for Cause after
the 90th Day, then all Options held by Executive, whether or not vested, shall
immediately terminate and become unexercisable.
                         (B) If Executive voluntary resigns after the 90th Day,
then all unvested Options held by Executive shall immediately terminate and
become unexercisable and all vested Options held by Executive shall remain
exercisable until three months after the date of cessation of service, in the
case of incentive stock options, or six months after the date of cessation of
service, in the case of non-qualified stock options.
                         (C) If, after the 90th Day, Executive’s employment
ceases as a result of death or disability, then all unvested Options held by
Executive shall immediately terminate and become unexercisable and all vested
Options held by Executive shall remain exercisable until the one year
anniversary of the date of cessation of service.
                         (D) If, after the 90th Day, the Company terminates
Executive’s employment without Cause or if Executive terminates her employment
due to a Constructive Termination, then: (1) one-half of all of Executive’s then
unvested Options will immediately vest and become exercisable; (2) the other
one-half of Executive’s then unvested Options will immediately terminate and
become unexercisable; and (3) all Executive’s vested Options (including those
which vested pursuant to clause (1)) shall expire on the two year anniversary of
the termination date.
                         (E) Notwithstanding the foregoing, in no event shall
any Option be exercisable after the date of expiration set forth in the Plan.
               (d) Healthcare Coverage. To the extent that Executive is eligible
to continue her medical coverage under COBRA, the Company will pay the premiums
for Executive’s COBRA coverage as they become due (including the premiums for
any dependent coverage she elects), until the earlier of: (i) the date Executive
accepts full time employment and/or becomes covered under another plan; (ii) the
date she is otherwise no longer eligible for COBRA coverage; or (iii) 12 months
after the effective date of separation.
               (e) Section 409A. Notwithstanding any provision of this Agreement
to the contrary, if, at the time of Executive’s termination of employment with
the Company, Executive is a “specified employee” as defined in Section 409A of
the Internal Revenue Code (the “Code”), and one or more of the payments or
benefits received or to be received by Executive pursuant to this Agreement or
otherwise would constitute deferred compensation subject to Section 409A, then:
                    (i) no such payment will be made under this Agreement until
the earliest of (A) the date which is six months after her “separation from
service” for any reason, other than “death” or “disability” (as such terms are
used in Section 409A(a)(2) of the Code), (B) the date of Executive’s “death” or
“disability” (as such terms are used in Section 409A(a)(2) of the Code), or
(C) the effective date of a “change in the ownership or effective control” of
the Company (as such term is used in Section 409A(a)(2)(A)(v) of the Code).

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                    (ii) For the sake of clarity, the provisions of this
Section 5.3(e) only apply to the extent required to avoid Executive’s incurrence
of any penalty tax or interest under Section 409A of the Code or any regulations
or United States Treasury guidance promulgated thereunder. In addition, if any
provision of this Agreement would cause Executive to incur any penalty tax or
interest under Section 409A of the Code or any regulations or Treasury guidance
promulgated thereunder, the Company may reform such provision to maintain to the
maximum extent practicable the original intent of the applicable provision
without violating the provisions of Section 409A of the Code.
          5.4 Cessation. If Executive violates any provision of Sections 3, 4, 7
or 8 of this Agreement, any severance payments or other benefits being provided
to Executive will cease immediately, and Executive will not be entitled to any
further compensation from the Company.
     6. Change in Control.
               (a) If Executive is employed by the Company at the time of a
Change in Control, and if on or within 360 days after the consummation of the
Change in Control Executive’s position is reduced such that she no longer serves
as the Chief Executive Officer of the Company, then all of Executive’s unvested
Options shall immediately vest and become exercisable.
               (b) “Change in Control” means the following and shall be deemed
to occur if any of the following events occur:
                    (i) Except as provided by subsection (iii) hereof, the
acquisition (other than from the Company) by any person, entity or “group,”
within the meaning of Section 13(d)(3) or 14(d)(2) of the Exchange Act
(excluding, for this purpose, the Company or its subsidiaries, or any employee
benefit plan of the Company or its subsidiaries which acquires beneficial
ownership of voting securities of the Company), of beneficial ownership (within
the meaning of Rule 13d-3 promulgated under the Exchange Act) of forty percent
(40%) or more of either the then outstanding shares of common stock or the
combined voting power of the Company’s then outstanding voting securities
entitled to vote generally in the election of directors; or
                    (ii) Individuals who, as of the effective date of the Plan,
constitute the Board (the “Incumbent Board”) cease for any reason to constitute
at least a majority of the Board, provided that any person becoming a director
subsequent to the date hereof whose election, or nomination for election by the
Company’s stockholders, is or was approved by a vote of at least a majority of
the directors then comprising the Incumbent Board (other than an election or
nomination of an individual whose initial assumption of office is in connection
with an actual or threatened election contest relating to the election of the
directors of the Company, as such terms are used in Rule 14a-11 of
Regulation 14A promulgated under the Exchange Act) shall be, for purposes of the
Plan, considered as though such person were a member of the Incumbent Board; or
                    (iii) Approval by the stockholders of the Company of a
reorganization, merger or consolidation with any other person, entity or
corporation, other than:

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                         (A) a merger or consolidation which would result in the
persons holding the voting securities of the Company outstanding immediately
prior thereto continuing to hold more than fifty percent (50%) of the combined
voting power of the voting securities of the Company or its successor which are
outstanding immediately after such merger or consolidation, or
                         (B) a merger or consolidation effected to implement a
recapitalization of the Company (or similar transaction) in which no person
acquires forty percent (40%) or more of the combined voting power of the
Company’s then outstanding voting securities; or
                    (iv) Approval by the stockholders of the Company of a plan
of complete liquidation of the Company or an agreement for the sale or other
disposition by the Company of all or substantially all of the Company’s assets.
Notwithstanding the foregoing, a Change in Control shall not be deemed to have
occurred (1) if the “person” is an underwriter or underwriting syndicate that
has acquired the ownership of 50% or more of the combined voting power of the
Company’s then outstanding voting securities solely in connection with a public
offering of the Company’s securities, or (2) if the “person” is an employee
stock ownership plan or other employee benefit plan maintained by the Company
that is qualified under the provisions of the Employee Retirement Income
Security Act of 1974, as amended.
     7. Other Agreements.
          7.1 Employees. For two years immediately following the termination
date of Executive’s employment for any reason, Executive agrees not to solicit,
attempt to solicit, induce, or otherwise cause any employee of the Company to
terminate his or her employment in order to become an employee, consultant or
independent contractor to or for any competitor of the Company.
          7.2 Noninterference. For one year immediately following the
termination date of Executive’s employment for any reason, Executive agrees not
to solicit, on Executive’s own behalf or for any entity that is in competition
with the Company, any person or entity that is doing business with the Company
or is an active prospect to do business with the Company for the purpose of
diverting Company’s business or active business opportunities in competition
with Company.
     8. Release. In exchange for the benefits and other consideration under this
Agreement to which Executive would not otherwise be entitled, Executive shall
enter into and execute a release substantially in the form attached hereto as
Exhibit B (the “Release Agreement”) upon her termination of employment. Unless
the Release Agreement is executed by Executive and delivered to the Company
within 21 days after the termination of Executive’s employment with the Company,
and the same is not revoked, Executive shall not receive any severance benefits
provided under this Agreement.

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     9. General Provisions.
          9.1 Notices. Any notices provided hereunder must be in writing and
shall be deemed effective upon the earlier of personal delivery (including
personal delivery by facsimile transmission) or the third day after mailing by
first class mail, to the Company at its primary office location and to Executive
at her address as listed on the Company payroll.
          9.2 Severability. Whenever possible, each provision of this Agreement
will be interpreted in such manner as to be effective and valid under applicable
law, but if any provision of this Agreement is held to be invalid, illegal or
unenforceable in any respect under any applicable law or rule in any
jurisdiction, such invalidity, illegality or unenforceability will not affect
any other provision or any other jurisdiction, and this Agreement will be
reformed, construed and enforced in such jurisdiction as if such invalid,
illegal or unenforceable provisions had never been contained herein or therein.
          9.3 Waiver. If either party should waive any breach of any provisions
of this Agreement, she or it shall not thereby be deemed to have waived any
preceding or succeeding breach of the same or any other provision of this
Agreement.
          9.4 Complete Agreement. This Agreement, together with the exhibits
attached hereto and incorporated herein, constitutes the entire agreement
between Executive and the Company and it is the complete, final, and exclusive
embodiment of their agreement and supersedes any prior agreement written or
otherwise between Executive and the Company with regard to this subject matter.
It is entered into without reliance on any promise or representation other than
those expressly contained herein or therein, and it cannot be modified or
amended except in a writing signed by an officer of the Company.
          9.5 Counterparts. This Agreement may be executed in separate
counterparts, any one of which need not contain signatures of more than one
party, but all of which taken together will constitute one and the same
agreement or plan. Signatures transmitted electronically or via facsimile shall
be deemed to be original signatures.
          9.6 Headings. The headings of the sections hereof are inserted for
convenience only and shall not be deemed to constitute a part hereof or thereof
nor to affect the meaning thereof.
          9.7 Successors and Assigns. This Agreement is intended to bind and
inure to the benefit of and be enforceable by Executive and the Company and
their respective successors, assigns, heirs, executors and administrators,
except that Executive may not assign any of her duties hereunder and she may not
assign any of her rights hereunder without the written consent of the Company.
          9.8 Arbitration. To provide a mechanism for rapid and economical
dispute resolution, Executive and the Company agree that any and all disputes,
claims, or causes of action, in law or equity, arising from or relating to this
Agreement (including the Release Agreement) and its enforcement, performance,
breach, or interpretation, will be resolved, to the fullest extent permitted by
law, by final, binding, and confidential arbitration before a single arbitrator
held in San Diego, California and conducted by Judicial Arbitration & Mediation

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Services/Endispute (“JAMS”), under its then-existing Rules and Procedures. The
parties shall be entitled to conduct adequate discovery, and they may obtain all
remedies available to the parties as if the matter had been tried in court. The
arbitrator shall issue a written decision which specifies the findings of fact
and conclusions of law on which the arbitrator’s decision is based. Judgment
upon the award rendered by the arbitrator may be entered by any court having
jurisdiction thereof. Unless otherwise required by law, the arbitrator will
award reasonable expenses (including reimbursement of the assigned arbitration
costs) to the prevailing party. Nothing in this Section 9.8 or in this Agreement
is intended to prevent either Executive or the Company from obtaining injunctive
relief in a court of competent jurisdiction to prevent irreparable harm pending
the conclusion of any such arbitration.
          9.9 Governing Law. All questions concerning the construction, validity
and interpretation of this Agreement will be governed by the law of the State of
California as applied to contracts made and to be performed entirely within
California, excluding the rules on conflicts of law.

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     IN WITNESS WHEREOF, the parties have executed this Agreement on the day and
year first above written.

              LA JOLLA PHARMACEUTICAL COMPANY
 
       
 
  By:   /s/ Craig R. Smith
 
       
 
      Craig R. Smith
 
      Chairman of the Board of Directors
 
            EXECUTIVE
 
            /s/ Deirdre Y. Gillespie, M.D.           Deirdre Y. Gillespie, M.D.

 

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EXHIBIT A

1.   The Forsyth Institute, Trustee   2.   The Communications Strategy Group
Inc., Advisory Board Member and Senior Medical Adviser

 

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EXHIBIT B
RELEASE AGREEMENT
     I understand that all of my positions with La Jolla Pharmaceutical Company
and its subsidiaries and affiliates (collectively, the “Company”) terminated
effective                      (the “Separation Date”). The Company has agreed
that if I choose to sign this Agreement, the Company will pay me severance
benefits (minus the standard withholdings and deductions) pursuant to the terms
of the Chief Executive Officer Employment Agreement entered into as of March 15,
2006 between myself and the Company (the “Employment Agreement”). I understand
that I am not entitled to any severance payment under the Employment Agreement
unless I sign this release agreement. I understand that in addition to this
severance, the Company will pay me all of my accrued salary and vacation, to
which I am entitled by law regardless of whether I sign this release agreement.
     In consideration for the severance payment I am to receive under my
Employment Agreement, I agree not to use or disclose any of the Company’s
proprietary information without written authorization from an executive officer
of the Company, to immediately return all Company property and documents
(including all embodiments of proprietary information) and all copies thereof in
my possession or control, and to release the Company and its current and former
officers, directors, agents, attorneys, employees, shareholders, and affiliates
from any and all claims, liabilities, demands, causes of action, attorneys’
fees, damages, or obligations of every kind and nature, whether they are known
or unknown, arising at any time prior to the date I sign this release agreement.
This general release includes, but is not limited to: all federal and state
statutory and common law claims, claims related to my employment or the
termination of my employment or related to breach of contract, tort, wrongful
termination, discrimination, wages or benefits, or claims for any form of
compensation. This release is not intended to release any claims I have or may
have against any of the released parties for (a) indemnification as a director,
officer, agent or employee under applicable law, charter document or agreement,
(b) severance and other termination benefits specifically provided for in my
employment agreement which constitutes a part of the consideration for this
release, (c) health or other insurance benefits based on claims already
submitted or which are covered claims properly submitted in the future,
(d) vested rights under pension, retirement or other benefit plans, or (e) in
respect of events, acts or omissions occurring after the date of this release
agreement.
     In releasing claims unknown to me at present, I am waiving all rights and
benefits under Section 1542 of the California Civil Code, and any law or legal
principle of similar effect in any jurisdiction: “A general release does not
extend to claims which the creditor does not know or suspect to exist in his
favor at the time of executing the release, which if known by her must have
materially affected her settlement with the debtor.”
     I acknowledge that I am knowingly and voluntarily waiving and releasing any
rights I may have under the federal Age Discrimination in Employment Act of
1967, as amended (the “ADEA”). I have been advised by this writing, as required
by the ADEA that: (a) my waiver and release do not apply to any claims that may
arise after my signing of this release; (b) I should consult with an attorney
prior to executing this release, (c) I have 21 days within

 

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which to consider this release (although I may choose to voluntarily execute
this release earlier); (d) I have seven days following the execution of this
release to revoke it; and (e) this release will not be effective until the
eighth day after this release agreement has been signed both by me and by the
Company (“Effective Date”).
     This release agreement constitutes the complete, final and exclusive
embodiment of the entire agreement between the Company and me with regard to the
subject matter hereof. I am not relying on any promise or representation by or
on behalf of the Company that is not expressly stated herein. This release
agreement may only be modified by a writing signed by both me and a duly
authorized officer of the Company.
     I accept and agree to the terms and conditions stated above:

                    Deirdre Y. Gillespie, M.D.
 
       
 
  Date:    
 
       

ACKNOWLEDGED:
La Jolla Pharmaceutical Company

         
By:
       
 
 
 
Name:    
 
  Title:    
 
       
Date: