Exhibit 10.1

REVENUE PURCHASE TERMINATION AGREEMENT AND

AMENDMENT OF FACILITY AGREEMENT

April 28, 2014

Reference is hereby made to:

(i) that certain REVENUE PURCHASE AGREEMENT (the “Revenue Purchase Agreement”),
dated December 29, 2011, by and between Deerfield Private Design Fund II, L.P.,
a Delaware limited partnership (“Private Design Fund II”), Deerfield Special
Situations Fund, L.P., a Delaware limited partnership (“DSS”), Horizon Santé
TTNP SARL, a Luxembourg limited company (“Horizon” and together with Private
Design Fund II and DSS, the “Purchasers”) and iCAD, Inc., a Delaware corporation
(“iCAD”); and

(ii) that certain FACILITY AGREEMENT (the “Facility Agreement”), dated as of
December 29, 2011, between iCAD, Private Design Fund II, DSS, Deerfield Private
Design International II, L.P. (“Private Design Fund II International”) and
Deerfield Special Situations Fund International Limited (“DSS International” and
together with Private Design Fund II, DSS and Private Design Fund II
International, the “Lenders”).

Capitalized terms used herein but not defined herein shall have the meanings set
forth in the Revenue Purchase Agreement. The Purchasers, the Lenders and iCAD
hereby agree as follows:

1. Contingent upon receipt of the payments set forth in paragraph 2 below, the
Revenue Purchase Agreement, including, without limitation, Section 2(e) of the
Revenue Purchase Agreement, is hereby terminated in its entirety and is of no
further force and effect and iCAD shall have no obligation to make any further
payments to the Purchasers thereunder.

2. In order to terminate the Revenue Purchase Agreement, iCAD hereby agrees to
pay the Purchasers (i) $4,100,000 in immediately funds on the date hereof and
(ii) the amount due to the Purchasers under Section 2(a)(i) of the Revenue
Purchase Agreement for the first quarter of 2014, which amount the parties agree
is $362,108.41. Such amounts shall be paid in the relative percentages set forth
in Section 2(d) of the Revenue Purchase Agreement pursuant to the wire
instructions previously provided by the Purchasers to iCAD.

3. iCAD represents and warrants to the Purchasers that it is not in active
discussions, nor has it had any discussions during the last six months, to sell
any assets in excess of $500,000.

4. The definition of “Final Payment Date” in the Facility Agreement is hereby
amended to eliminate the ability of iCAD to extend such date to the sixth
anniversary of the date of the Facility Agreement and shall now be amended to
read as follows:

“Final Payment Date” means the earlier of (i) the date on which the Borrower
repays the Notes (together with any other amounts accrued and unpaid under the
Financing Documents) pursuant to this Agreement or (ii) the fifth anniversary of
the date hereof.

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IN WITNESS WHEREOF, the Parties have caused this Revenue Purchase Termination
Agreement and Amendment of Facility Agreement to be executed by their duly
authorized representatives as of the date first set forth above.

 

  DEERFIELD PRIVATE DESIGN FUND II, L.P.   By:   Deerfield Mgmt, L.P., General
Partner   By:   J. E. Flynn Capital LLC, General Partner   By:   LOGO
[g721034ex10_1pg2a.jpg]    

 

  Name:   James E. Flynn   Title:   President   DEERFIELD PRIVATE DESIGN  
INTERNATIONAL II, L.P.   By:   Deerfield Mgmt, L.P., General Partner   By:   J.
E. Flynn Capital LLC, General Partner   By:   LOGO [g721034ex10_1pg2b.jpg]    

 

  Name:   James E. Flynn   Title:   President   DEERFIELD SPECIAL SITUATIONS
FUND, L.P.   By:   Deerfield Mgmt. L.P., General Partner   By:   J. E. Flynn
Capital LLC, General Partner   By:   LOGO [g721034ex10_1pg2c.jpg]    

 

  Name:   James E. Flynn   Title:   President   DEERFIELD SPECIAL SITUATIONS
FUND   INTERNATIONAL LIMITED   By:   LOGO [g721034ex10_1pg2d.jpg]    

 

  Name:   James E. Flynn   Title:   Director

 

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  HORIZON SANTÉ TTNP SARL   By:   LOGO [g721034ex10_1pg3a.jpg]    

 

  Name:   Alexis Cazé   Title:   Manager A   By:   LOGO [g721034ex10_1pg3b.jpg]
   

 

  Name:   Florence Gerardy   Title:   Manager B   ICAD, INC.   By:      

 

  Name:     Title:  

 

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  HORIZON SANTÉ TTNP SARL   By:      

 

  Name:   Alexis Cazé   Title:   Manager   By:      

 

  Name:   Florence Gerardy   Title:   Manager   ICAD, INC.   By:   LOGO
[g721034ex10_1pg4.jpg]    

 

  Name:   Kevin Burns   Title:   CFO

 

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