EXHIBIT 10.42

 

Portions of this exhibit were omitted and filed separately with the Secretary of
the Commission pursuant to an application for confidential treatment filed with
the Commission pursuant to Rule 24b-2 under the Securities Exchange Act of 1934.
Such portions are marked by a series of asterisks.

 

December 18, 2003

 

BY FAX and FEDERAL EXPRESS

 

Novo Nordisk A/S

Novo Allé

2880 Bagsvaerd

Denmark

 

    Attention: Vice President, Business Development

    Fax: 011-45-4442-1830

 

Novo Nordisk Health Care AG

Andreasstrasse 15

CH – 8050 Zurich Oerlikon

Switzerland

 

Attention: Head of Hematology Business Unit

Fax: 011-41-43-222-4404

 

Re: Research, Development and License Agreement Among Neose

   Technologies, Inc. and Novo Nordisk A/S and Novo Nordisk

   Health Care AG dated as of November 17, 2003 (the “Agreement”)

   (relating to *****)                                         
                                    

 

Ladies and Gentlemen:

 

The purpose of this letter is to amend the Agreement in certain respects to
reflect our recent discussions. Capitalized terms used and not otherwise defined
in this letter are used as defined in the Agreement.

 

1. Section 3.2.1 of the Agreement is hereby amended and restated in its entirety
as follows:

 

***** upon the ***** to occur of: (i) the first date on which there shall be a
candidate which has been shown to meet the *****, and Neose shall have delivered
to Novo ***** for the production of such candidate; and (ii) the *****
anniversary of the Effective Date.

--------------------------------------------------------------------------------

Novo Nordisk A/S

Novo Nordisk Health Care AS

December 18, 2003

Page 2

 

2. Section 5.1.1 of the Agreement is hereby amended and restated in its entirety
as follows:

 

Exclusive License. As of the Effective Date, Neose hereby grants, and agrees to
grant, to Novo an exclusive (even as to Neose), royalty-bearing license in the
Field of Use under the Neose Technology used or required to be used in the Field
of Use during the Term, (i) to conduct research, sample, develop (including
clinical development), manufacture, make, use, market, promote, sell, offer for
sale, have sold, distribute, import and export New Products in the Territory,
and (ii) to use the Reagents in the Territory solely for the purpose of making
New Products. Such license does not permit Novo (x) to practice or use the Neose
Technology outside the Field of Use or (y) to sublicense any of its rights
without the prior written approval of Neose, except as provided in Section
5.1.2.

 

3. Exhibit 1.24 to the Agreement is hereby amended and restated as set forth in
Attachment A to this letter agreement.

 

This letter amends the Agreement only as herein set forth and in all other
respects the Agreement is ratified and confirmed. Three originals of this letter
amendment are enclosed in our Federal Express package, each of which has been
executed on behalf of Neose. Please indicate the agreement of Novo Nordisk A/S
and Novo Nordisk Health Care AG with the terms of this letter by having this
letter executed on behalf of each company in the space provided below, and
return one fully executed copy to Neose by fax (215-315-9100) and Federal
Express or DHL courier (each to the attention of our General Counsel).

 

Sincerely yours,

 

NEOSE TECHNOLOGIES, INC.

 

By:

 

/s/ George J. Vergis

--------------------------------------------------------------------------------

Name:

 

George J. Vergis, Ph.D.

Title:

  Senior Vice President, Business and Commercial Development

--------------------------------------------------------------------------------

Novo Nordisk A/S

Novo Nordisk Health Care AS

December 18, 2003

Page 3

 

Accepted and agreed:

 

NOVO NORDISK A/S

         

NOVO NORDISK HEALTH CARE AG

By:

 

/s/ Pierre Honore

     

By:

 

/s/ Klaus Ehrlich

   

--------------------------------------------------------------------------------

         

--------------------------------------------------------------------------------

Name:

 

Pierre Honore

     

Name:

 

Klaus Ehrlich

Title:

 

VP Scientific Licensing

     

Title:

 

SVP Europe

cc:

 

Novo Nordisk A/S

               

Attention: General Counsel

               

Fax: 011-45-4498-0670

           

--------------------------------------------------------------------------------

ATTACHMENT A TO LETTER AMENDMENT DATED DECEMBER 18, 2003

 

Confidential Information – Neose Technologies, Inc.

   EXHIBIT 1.24

 

NEOSE PATENTS AS OF THE DATE OF THIS AGREEMENT

 

******

--------------------------------------------------------------------------------

                                  

Country

--------------------------------------------------------------------------------

  

Case Type

--------------------------------------------------------------------------------

  

Status

--------------------------------------------------------------------------------

  

Application Number

--------------------------------------------------------------------------------

  

Filing Date

--------------------------------------------------------------------------------

  

Patent Number

--------------------------------------------------------------------------------

  

Issue Date

--------------------------------------------------------------------------------

  

Expiration Date

--------------------------------------------------------------------------------

******

   PCT    Granted    ******    ******    ******    ******    ****** ******   
DIV    Pending    ******    ******                ******    PCT    Pending   
******    ******                ******    PCT    Published    ******    ******
               ******    PCT    Pending    ******    ******               
******    PCT    Published    ******    ******                ******    PCT   
Pending    ******    ******               

******

   PCT    Granted    ******    ******    ******    ******    ****** ******   
ORD    Pending    ******    ******    ******           ******    CON    Pending
   ******    ******                ******    CON    Published    ******   
******                ******    DIV    Published    ******    ******          
     ******    CON    Pending    ******    ******                ******    PRO
   Expired    ******    ******               

******

   RCE    Granted    ******    ******    ******    ******    ******

******

--------------------------------------------------------------------------------

                                  

Country

--------------------------------------------------------------------------------

  

Case Type

--------------------------------------------------------------------------------

  

Status

--------------------------------------------------------------------------------

  

Application Number

--------------------------------------------------------------------------------

  

Filing Date

--------------------------------------------------------------------------------

  

Patent Number

--------------------------------------------------------------------------------

  

Issue Date

--------------------------------------------------------------------------------

  

Expiration Date

--------------------------------------------------------------------------------

******    ORD    Published    ******    ******    ******           ******    PRO
   Expired    ******    ******              ****** ******    PRO    Expired   
******    ******              ******

******

   PRO    Expired    ******    ******              ******

******

   PRO    Expired    ******    ******              ******

******

--------------------------------------------------------------------------------

                                  

Country

--------------------------------------------------------------------------------

  

Case Type

--------------------------------------------------------------------------------

  

Status

--------------------------------------------------------------------------------

  

Application Number

--------------------------------------------------------------------------------

  

Filing Date

--------------------------------------------------------------------------------

  

Patent Number

--------------------------------------------------------------------------------

  

Issue Date

--------------------------------------------------------------------------------

  

Expiration Date

--------------------------------------------------------------------------------

******    CIP    Pending    ******    ******               

******

--------------------------------------------------------------------------------

                                  

Country

--------------------------------------------------------------------------------

  

Case Type

--------------------------------------------------------------------------------

  

Status

--------------------------------------------------------------------------------

  

Application Number

--------------------------------------------------------------------------------

  

Filing Date

--------------------------------------------------------------------------------

  

Patent Number

--------------------------------------------------------------------------------

  

Issue Date

--------------------------------------------------------------------------------

  

Expiration Date

--------------------------------------------------------------------------------

******    CON    Pending    ******    ******               

--------------------------------------------------------------------------------

ATTACHMENT A TO LETTER AMENDMENT DATED DECEMBER 18, 2003

 

Confidential Information – Neose Technologies, Inc.

   EXHIBIT 1.24

 

******

--------------------------------------------------------------------------------

                                  

Country

--------------------------------------------------------------------------------

  

Case Type

--------------------------------------------------------------------------------

  

Status

--------------------------------------------------------------------------------

  

Application Number

--------------------------------------------------------------------------------

  

Filing Date

--------------------------------------------------------------------------------

  

Patent Number

--------------------------------------------------------------------------------

  

Issue Date

--------------------------------------------------------------------------------

  

Expiration Date

--------------------------------------------------------------------------------

******    CIP    Pending    ******    ******               

******

--------------------------------------------------------------------------------

                                  

Country

--------------------------------------------------------------------------------

  

Case Type

--------------------------------------------------------------------------------

  

Status

--------------------------------------------------------------------------------

  

Application Number

--------------------------------------------------------------------------------

  

Filing Date

--------------------------------------------------------------------------------

  

Patent Number

--------------------------------------------------------------------------------

  

Issue Date

--------------------------------------------------------------------------------

  

Expiration Date

--------------------------------------------------------------------------------

******    CIP    Pending    ******    ******               

******

--------------------------------------------------------------------------------

                                  

Country

--------------------------------------------------------------------------------

  

Case Type

--------------------------------------------------------------------------------

  

Status

--------------------------------------------------------------------------------

  

Application Number

--------------------------------------------------------------------------------

  

Filing Date

--------------------------------------------------------------------------------

  

Patent Number

--------------------------------------------------------------------------------

  

Issue Date

--------------------------------------------------------------------------------

  

Expiration Date

--------------------------------------------------------------------------------

******    CIP    Pending    ******    ******               

******

--------------------------------------------------------------------------------

                                  

Country

--------------------------------------------------------------------------------

  

Case Type

--------------------------------------------------------------------------------

  

Status

--------------------------------------------------------------------------------

  

Application Number

--------------------------------------------------------------------------------

  

Filing Date

--------------------------------------------------------------------------------

  

Patent Number

--------------------------------------------------------------------------------

  

Issue Date

--------------------------------------------------------------------------------

  

Expiration Date

--------------------------------------------------------------------------------

******    PCT    Granted    ******    ******    ******    ******    ******
******    PCT    Published    ******    ******                ******    ORD   
Published    ******    ******    ******           ******    CIP    Granted   
******    ******    ******    ******    ******

--------------------------------------------------------------------------------

ATTACHMENT A TO LETTER AMENDMENT DATED DECEMBER 18, 2003

 

Confidential Information – Neose Technologies, Inc.

   EXHIBIT 1.24

 

******

--------------------------------------------------------------------------------

                                  

Country

--------------------------------------------------------------------------------

  

Case Type

--------------------------------------------------------------------------------

  

Status

--------------------------------------------------------------------------------

  

Application Number

--------------------------------------------------------------------------------

  

Filing Date

--------------------------------------------------------------------------------

  

Patent Number

--------------------------------------------------------------------------------

  

Issue Date

--------------------------------------------------------------------------------

  

Expiration Date

--------------------------------------------------------------------------------

******

   PCT    Granted    ******    ******    ******    ******    ******

******

   EPC    Granted    ******    ******    ******    ******    ******

******

   EPC    Granted    ******    ******    ******    ******    ******

******

   PCT    Granted    ******    ******    ******    ******     

******

   EPC    Granted    ******    ******    ******    ******    ******

******

   PCT    Granted    ******    ******    ******    ******    ******

******

   EPC    Granted    ******    ******    ******    ******    ******

******

   PCT    Granted    ******    ******    ******    ******    ******

******

   EPC    Granted    ******    ******    ******    ******    ******

******

   PCT    Granted    ******    ******    ******    ******    ******

******

   EPC    Granted    ******    ******    ******    ******    ******

******

   ORD    Published    ******    ******    ******          

******

   EPC    Granted    ******    ******    ******    ******    ******

******

   EPC    Granted    ******    ******    ******    ******    ******

******

   EPC    Granted    ******    ******    ******    ******    ******

******

   EPC    Granted    ******    ******    ******    ******    ******

******

   ORD    Granted    ******    ******    ******    ******    ******

******

   CON    Granted    ******    ******    ******    ******    ******

******

   DIV    Granted    ******    ******    ******    ******    ******

--------------------------------------------------------------------------------

ATTACHMENT A TO LETTER AMENDMENT DATED DECEMBER 18, 2003

 

Confidential Information – Neose Technologies, Inc.

   EXHIBIT 1.24

 

PROVISIONAL: The Parties acknowledge that the following may be included by
amendment.

 

******

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Country

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Sub Case

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Case Type

--------------------------------------------------------------------------------

  

Status

--------------------------------------------------------------------------------

  

Application Number

--------------------------------------------------------------------------------

  

Filing Date

--------------------------------------------------------------------------------

  

Patent Number

--------------------------------------------------------------------------------

  

Issue Date

--------------------------------------------------------------------------------

  

Expiration Date

--------------------------------------------------------------------------------

******         PCT    Published    ******    ******                ******     
   PCT    Published         ******                ******         PCT   
Published    ******    ******                ******         PCT    Published   
     ******                ******         PCT    Published         ******     
          ******         ORD    Published    ******    ******    ******        
  ******         CIP    Allowed    ******    ******                ******    D1
   DIV    Published    ******    ******                ******    D2    DIV   
Published    ******    ******                ******    D3    DIV    Published   
******    ******                ******    D4    DIV    Published    ******   
******                ******    D5    DIV    Published    ******    ******