Exhibit 10.90

AMENDMENT NO. 2 TO NOTE PURCHASE AGREEMENT

          This AMENDMENT NO. 2 is made as of the 3rd day of May, 2002 (the
“Amendment”) by and between Kevin Kimberlin Partners, L.P., a Delaware limited
partnership (“KKP”), The Immune Response Corporation, a Delaware corporation
(“Seller”), and Oshkim Limited Partnership (“Oshkim”).

          WHEREAS, Seller, KKP and Oshkim entered into that certain Note
Purchase Agreement dated as of November 9, 2001, as amended by Amendment No. 1
to Note Purchase Agreement dated as of February 14, 2002 (the “Agreement”).

          WHEREAS, Seller proposes to issue and sell Additional Securities to
Oshkim and Oshkim wishes to purchase Additional Securities (as defined in the
Agreement) from Seller.

          WHEREAS, the parties desire to amend the Agreement as set forth below.

          NOW, THEREFORE, in consideration of the foregoing premises and the
mutual covenants set forth below, the parties hereby amend the Agreement and
agree as follows:

  1. Effective as of the date of this Amendment, the Agreement is hereby amended
as follows:

  a. The third recital is hereby amended to substitute “$4,000,000” for
“$2,000,000”.

  b Section 6.2(a) is hereby amended to add a new last sentence which shall read
in its entirety as follows:

“Notwithstanding the foregoing, Seller and Oshkim acknowledge and accept that as
of the date of Amendment No. 2 to this Agreement Seller does not have reserved
and available out of its authorized but unissued shares of Common Stock
sufficient shares of Common Stock for the purpose of issuing Common Stock upon
the exercise in full of the Warrants issued to Oshkim on May 3, 2002. Seller
shall promptly take all corporate action as may be necessary to increase its
authorized but unissued shares of Common Stock to such number of shares as shall
be sufficient for reserving and making available shares of Common Stock issuable
upon the exercise in full of the Warrants issued to Oshkim on May 3, 2002.”

          2.        Except as specifically provided herein, the Agreement, as
originally executed by the parties thereto and as amended hereby, shall remain
in full force and effect.

          3.        Any defined terms not defined herein shall have the
respective meanings set forth in the Agreement.

          4.        This Amendment may be executed in counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument.

          5.        This Amendment shall be governed by and construed in
accordance with the internal laws of the State of New York applicable to
agreements made and to be performed entirely within such jurisdiction.

 

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          IN WITNESS WHEREOF, the parties hereto have executed this Amendment as
of the date first above written.

  KEVIN KIMBERLIN PARTNERS, L.P.

By:______________________________________

  Name: _________________________________
Title: __________________________________

  OSHKIM LIMITED PARTNERSHIP

By: _____________________________________

  Name:_________________________________
Title:__________________________________

  THE IMMUNE RESPONSE CORPORATION

By:______________________________________

  Name:__________________________________
Title:___________________________________

 

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