Exhibit 10.46
***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4) and 240.24b-2
FIRST AMENDMENT
TO
LICENSE AGREEMENT
DATED AS OF SEPTEMBER 14, 1999
by and between
THE UNIVERSITY OF SOUTHERN CALIFORNIA
And
BIO-MANAGEMENT, INC. (NOW KNOWN AS CELL-MATRIX, INC.)
     This FIRST AMENDMENT (the “Amendment”) dated as of February 23, 2007 (the
“Amendment Date”), is entered into by and between the University of Southern
California (hereinafter “USC”), a California nonprofit corporation with its
principal place of business at University Park, Los Angeles, California 90089,
and Cell-Matrix, Inc., a Nevada corporation, formerly known as Bio-Management,
Inc., (a wholly-owned subsidiary of Micromet, Inc., formerly known as CancerVax
Corporation) (hereafter “Licensee”), having its principal place of business at
2110 Rutherford Road, Carlsbad, CA 92008, and amends the License Agreement
entered into by and between Licensee and USC dated as of September 14, 1999 (the
“License Agreement”). Licensee and USC are referred to in this Amendment
individually as a “Party” and collectively as “Parties.”
     In consideration of the mutual covenants contained in this Amendment and
other good and valuable consideration, the receipt and sufficiency of which is
hereby acknowledged, the Parties agree as follows:
1. Definitions
     All capitalized terms used in this Amendment have the meaning as defined in
the first paragraph above and throughout this Amendment. Any capitalized terms
used in this Amendment without definition have the meanings given to such terms
in the License Agreement.
2. Amendments
     2.1 Section 3. subsection a. paragraph i. of the License Agreement is
hereby amended and restated to read in full as follows:
“i. the exclusive worldwide license in the FIELD OF USE under the PATENTS to
make, have made, use, offer for sale, sell, and import the PRODUCT(S); and”

 

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     2.2 Section 3. subsection b. of the License Agreement is hereby amended by
inserting the following sentence after the second sentence of subsection b.:
. . . “Licensee agrees that PRODUCTS used or sold in the United States shall be
manufactured substantially in the United States, unless a written waiver is
obtained in advance from the relevant U.S. federal agency.” . . .
     2.3 Section 10 of the License Agreement is hereby amended by inserting the
following sentence after the first sentence of Section 10:
“USC shall not withhold permission, if (i) the agreement with a SUBLICENSEE is
in full compliance with this Agreement, and (ii) the SUBLICENSEE is capable and
shall use commercially reasonable efforts to develop a PRODUCT as specified in
Section 15.d. and Section 25.”
     2.4 A new Section 15. subsection d. shall be inserted and read as follows:
“Unless terminated pursuant to the other provisions of this Agreement, this
Agreement shall terminate on February 21, 2008, unless (i) Licensee has granted
a sublicense to a third party and such SUBLICENSEE uses commercially reasonable
efforts to develop a PRODUCT in compliance with this Agreement, or (ii) Licensee
itself uses commercially reasonable efforts to develop a PRODUCT in compliance
with this Agreement.”
     2.5 Appendix A of the Agreement shall be amended and restated to read in
full as set forth in Schedule 1 of this Amendment.
3. Exclusion of Patents
     For the avoidance of doubt and notwithstanding anything in this Amendment
or the License Agreement, the patents and patent applications listed in
Schedule 2 of this Amendment are hereby expressly excluded from the definition
of “PATENT” or “PATENTS” in the License Agreement.
4. Miscellaneous
     4.1 In the event of any conflict between the terms of this Amendment and
the terms of the License Agreement, the terms of this Amendment shall control.
     4.2 This Amendment may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument.
     4.3 USC hereby acknowledges and agrees that it has received the progress
report pursuant to Section 25 of the License Agreement for 2006, that
Cell-Matrix, Inc. as of the Amendment Date is a licensee in good standing and in
compliance with the terms of the License

 

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Agreement, and except as expressly modified by this Amendment, the terms and
provisions of the License Agreement shall remain in full force and effect.
[Remainder of page intentionally left blank. Signature page follows.]

 

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     IN WITNESS WHEREOF, the Parties have caused this Amendment to be executed
as of the Amendment Date by signature of their duly authorized representatives.

     
Cell-Matrix, Inc.
  University of Southern California
 
   
/s/ Jens Hennecke
  /s/ Dennis F. Dougherty
Name: Jens Hennecke
  Name: Dennis F. Dougherty
Title: VP of Business Development
  Title: Senior Vice President, Finance and CFO
Date: 3-2-2007
  Date: 3-2-2007

 

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Schedule 1
Appendix A
Patents/patent applications relating to [***]

                  [***]   [***]   [***]   [***]   [***] [***]  
[***]
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Schedule 2
List of applications and patents of the University of Southern California
related to [***]

                  Micromet                 ref no.   Application/Patent title  
application no.   published   status [***]  
[***]
  [***]   [***]   [***]                   [***]  
[***]
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  [***]   [***]   [***]

 

***   Certain information on this page has been omitted and filed separately
with the Commission. Confidential treatment has been requested with respect to
the omitted portions.