Exhibit 10.1

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October 26, 2006

Multicell Technologies, Inc.

701 George Washington Highway

Lincoln

RI 02865

USA

Dear Sirs

Worldwide Exclusive License Agreement dated December 31st 2005 made between
Multicell Technologies. Inc. (“Multicell”) and Amarin Neuroscience Limited
(“Amarin”) (the “Agreement”)

We refer to the Agreement, as amended by letter agreement dated June 27, 2006
(“First Amendment Letter”) and to recent discussions between Multicell and
Amarin relating to the payment of the sum of $400,000 (the “Sum”) remaining
payable by Multicell to Amarin pursuant to Section 3.2(a) of the Agreement, as
amended by the First Amendment Letter.

As per your proposal and our further discussions, it is agreed that the
milestone and payment terms for the Sum (as set out in the Agreement, as amended
by the First Amendment Letter) shall be further revised to payment by instalment
(“Instalment(s)”) as follows:

 

  •   $100,000 due on November 3, 2006;

 

  •   $300,000 due on December 15, 2006

Notwithstanding the above, the Sum or any outstanding Instalment, shall in any
event be due and payable in full by December 15, 2006.

In the event that Multicell should raise finance in excess of $3,000,000 in a
financing (other than bridging finance or equity line credit) prior to
December 15, 2006, all outstanding amounts of the Sum shall be immediately
payable.

In the event that Multicell defaults in paying any of the Sum and/or the
Instalments and notwithstanding Section 9.2(a) of the Agreement, Amarin shall,
at its option, thereafter be at liberty to terminate the Agreement on the giving
of seven (7) days prior written notice to Multicell at any time.

For the avoidance of doubt Multicell shall have no cure period in respect of the
non payment of the above Sum and/or the Instalments by the due date(s) set forth
above.

Amarin Neuroscience Ltd · 1st Floor · Magdalen Centre North · The Oxford Science
Park · Oxford · OX4 4GA · UK

Tel: +44 (0)1865 784210 · Fax: +44 (0) 1865 784213 · Email:
admin@amarin-neuro.com · www.amarincorp.com

Registered In Scotland No. 179838

Registered Office: 4th Floor · Saltire Court · 20 Castle Terrace · Edinburgh ·
EH1 2EN · Scotland · UK

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In the event that this letter agreement is not counter signed by Multicell and
returned to Amarin on or before October 27, 2006, then this letter agreement
shall be null and void.

Save as set out above, the parties’ respective rights and obligations under the
Agreement shall remain unaffected.

 

Yours faithfully

/s/ Alan Cooke

Duly authorised, for and on behalf of

Amarin Neuroscience Limited

 

Amendment terms agreed

/s/ Stephen Chang

Duly authorised, for and on behalf of

Multicell Technologies, Inc.

Date Oct 26, 2006

Amarin Neuroscience Ltd · 1st Floor · Magdalen Centre North · The Oxford Science
Park · Oxford · OX4 4GA · UK

Tel: +44 (0)1865 784210 · Fax: +44 (0)1865 784213 · Email:
admin@amarin-neuro.com · www.amarincorp.com

Registered In Scotland No. 179838

Registered Office: 4th Floor · Saltire Court · 20 Castle Terrace · Edinburgh ·
EH1 2EN · Scotland · UK

 

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