Exhibit 10.21

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED AS
"(CONFIDENTIAL TREATMENT REQUESTED)" IN THE TEXT, HAS BEEN OMITTED AND FILED
SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24b-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Terms and Conditions for the Manufacture of Products by Ben Venue Laboratories,
Inc

This signed agreement is required to provide services and manufacture your
Product at Ben Venue Laboratories, Inc. This agreement covers all Products &
services for the development and manufacture of Products for your company at Ben
Venue and remains in place until superceded by a formal supply agreement.

By:

Ben Venue Laboratories, Inc.
300 Northfield Road
Bedford, Ohio 44146

Hereinafter referred to as BVL, and

CUSTOMER NAME
ADDRESS
CITY, STATE, ZIP

Hereinafter referred to as Customer,

agree to the following terms and conditions in reference to the development and
manufacture of Customer's Products at BVL.

1.     Facilities

1.1 BVL will provide manufacturing facilities that conform to current Good
Manufacturing Practices established by the FDA and will perform its obligations
hereunder and supply Product in accordance with all applicable laws and
regulations and in accordance with written documentation provided to Customer.

1.2 All services will be performed at BVL facilities unless otherwise agreed to
in writing by BVL and Customer.

2.     Audits

2.1 Customer and any third-party consultant appointed by Customer shall have
reasonable access to observe and inspect BVL's facilities and procedures with
respect to the Products including all analytical and manufacturing documentation
directly related to the Products upon scheduling in advance with BVL's
compliance manager. Any such Customer appointed third-party consultant must be
pre-approved by BVL such approval not to be unreasonably withheld and be bound
in writing to the Confidentiality Agreement signed by Customer and BVL. Customer
shall have the right to one annual compliance audit each year to (i) observe,
inspect and audit the manner in which BVL conducts quality control of Customer
Products, (ii) inspect BVL's plant and records relating to BVL's quality and
other controls related to its manufacture of the Products. For cause audits will
be scheduled as mutually agreed to by the parties.

2.2 Customer's employees and/or representatives including consultants who
inspect BVL facilities shall comply with all BVL policies and procedures.
Customer assumes all liability resulting from presence of Customer's employees
at BVL facilities, except to the extent that any such liability is a result of
BVL's negligence or willful misconduct.

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3.     Materials & Documentation

3.1 Customer will provide active drug substance and any other mutually agreed to
Customer supplied components at (CONFIDENTIAL TREATMENT REQUESTED) in advance of
scheduled manufacturing date in accordance with BVL's procedures.

3.2 Customer must give BVL permission in writing to do ID only by label
verification of the active drug substance, if no identification test is to be
performed at BVL.

3.3 BVL will release all materials provided by BVL.

3.4 Customer will provide materials and manufacturing information necessary for
the development and manufacturing of Products.

3.5 Customer will specify samples to be sent for testing and provide address for
shipment on the purchase order for all sample request not included in the Master
Production Record.

3.6 BVL will provide, at Customer's request, a copy of the BVL Drug Master File
(DMF) and authorization for FDA to access the DMF. This may be used by the
Customer to prepare a Regulatory filing.

3.7 BVL shall deliver Product and/or Services to Customer in compliance with
quotations provided to Customer which shall be referenced by quotation number on
Customer's purchase order, which shall include by reference specifications
mutually agreed upon by the Customer and BVL. For manufacturing services said
specifications must be incorporated in the master batch record or in a special
instruction to a specific batch record.

3.8 BVL will submit to Customer a Certificate of Compliance, a Certificate of
Analysis listing results of testing, and a completed batch record for each lot
of Product shipped.

3.9 Customer will provide written QC testing requirements, methods,
specifications and reference standard for the Active Pharmaceutical Ingredient
and drug Product. Customer will approve initial testing documents, the Master
Production Record and any revisions of the documents thereafter. Revisions of
approved documents requested within eight weeks of scheduled manufacturing or
other services may cause a delay or postponement of manufacturing and/or other
services requested by the Customer.

3.10 Customer is responsible for notifying BVL with instruction for disposition
of tailings and rejects, which will be incorporated into the Master Batch Record
and include a shipment address for tailing and rejects if Customer requests
return of tailings and rejects.

3.11 Customer will evaluate BVL Certificate of Analysis and perform at least an
identity assay upon all batches of Product manufactured for the Customer.

3.12 Customer will be financially responsible for all materials purchased by BVL
on Customer's behalf based on requirements communicated by Customer to BVL in
forecast and/or Purchase Orders, in the event the materials become obsolete for
any reason, including but not limited to termination of the project by Customer
for any reason.

4.     Purchase Orders

4.1 Customer will provide Purchase Orders with information defined in Item 4.2
(CONFIDENTIAL TREATMENT REQUESTED) in advance of the requested manufacturing
date or (CONFIDENTIAL TREATMENT REQUESTED) in advance of the requested delivery
date. Purchase Orders for other services will be issued by the Customer on a
mutually agreed upon timeline with BVL. All purchase orders will reference the
BVL quotation number(s) provided to Customer.

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4.2 The following information must be included on all Purchase Orders

4.2.1 BVL end item number or description of service outlined in the Quotation
provided to Customer

4.2.2 BVL Product description or service description

4.2.3 Batch Size in vials from Quotation

4.2.4 Number of Batches

4.2.5 Delivery Date (Date for BVL to release the lot and deliver Product & batch
record)

4.2.6 BVL Quotation Number for Product/Service

4.2.7 Delivery Address

4.2.8 Shipping requirements & Instructions (temperature, dedicated trucks,
preferred carrier, overnight etc.) Contact name for Preferred Carrier,
Temperature Monitors, Ship on BVL Release or Hold for Customer Authorization to
Ship or Ship in Quarantine.

4.2.9 Billing Address

4.2.10 Special Instructions for Specific Batch

(Examples)
"Annual Stability Batch"
"Process Validation Batch"
"Special Sampling Instructions" mutually agreed to in advance

4.2.11 Customer Lot# and Expiration Date if Applicable

5.     Forecast & Planning

5.1 Customer shall submit at least (CONFIDENTIAL TREATMENT REQUESTED) before the
start of each calendar quarter an updated estimate for both volumes and delivery
dates of its requirement for Product for the following (CONFIDENTIAL TREATMENT
REQUESTED). The estimated requirements for the (CONFIDENTIAL TREATMENT
REQUESTED) of these (CONFIDENTIAL TREATMENT REQUESTED) shall be considered firm
orders for which Customer will issue purchase orders pursuant to Section 4 of
this agreement. In addition a (CONFIDENTIAL TREATMENT REQUESTED) forecast will
be submitted by the Customer to BVL on an annual basis due by February 28th each
year for the following (CONFIDENTIAL TREATMENT REQUESTED). Ben Venue shall
provide Customer with a forecast template to be used for all forecasts. All
forecasts provided shall be non binding on either party, unless agreed to in
writing by both parties and shall be subject to acceptance of a purchase order
which will be confirmed in writing by BVL.

6.     Insurance and Liability Limits

6.1 Customer will retain title to and risk of loss of the bulk active drug
substance, in process and in finished Product, except if BVL damages the
material while in storage at BVL's facility, due to BVL's negligence or willful
misconduct. BVL will maintain general liability insurance in an amount
sufficient to cover the replacement cost of Customer supplied raw materials up
to (CONFIDENTIAL TREATMENT REQUESTED), and will include Customer as an
additional insured under the relevant policies. For Process related losses see
BVL 6.2.

6.2 After such time as all Production and Testing Procedures have been fully
developed and validated and a complete and successful technical transfer to
BVL's production department has occurred, BVL will reimburse Customer up to
$(CONFIDENTIAL TREATMENT REQUESTED) per batch for any loss of customer supplied
raw materials and/or components and will issue a credit for the manufacturing
fee, if an invoice for the manufacturing fee has been issued for the production,
for any batch of Product which does not meet the specifications contained in the
master batch record,

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pro-rated over the usable portion of the batch if applicable. The monetary
values of all Customer supplied raw materials and components must be disclosed
to BVL prior to production in the questionnaire provided by BVL to Customer. The
Customer is responsible for notifying BVL in writing of any changes in the value
of the raw material or components supplied to BVL. Further, any such claim for a
loss must be due to failure of BVL's personnel to follow directions or to gross
negligence on their part.

6.3 Neither party will be liable to the other party for consequential damages,
including but not limited too loss of sales, profit, clinical trial costs,
regardless of the reason for such consequential damages.

7.     Safety

7.1 BVL and Customer shall mutually develop safety procedures for the handling
and manufacture of Product and treatment and disposal of waste relating thereto
that comply with all federal and state environmental and occupational safety and
health requirements. Such procedures shall be included in a separate document
and shall be followed by BVL and Customer in performing services under this
agreement.

7.2 Customer will provide Material Safety Data Sheets and other handling
information required by law, to be provided prior to shipment of any material to
BVL. BVL will not receive any material until all required information has been
provided.

7.3 Customer will provide BVL with all information regarding safety of
biological and drug Products and will maintain currency of such information.

8.     Payment and Pricing

8.1 Customer acknowledges that all invoices must be paid to BVL no later than
(CONFIDENTIAL TREATMENT REQUESTED) days after the date of invoice, payment terms
are (CONFIDENTIAL TREATMENT REQUESTED). For manufacturing services an invoice
will be issued after BVL's Documentation Department has issued a Certificate of
Compliance or, if applicable, at the time a Quarantine shipment is made, for non
production services invoices will be sent in accordance with the terms outlined
in Proposals / Quotations provided to Customer as work is performed for those
services. Any invoice(s) remaining to be paid after (CONFIDENTIAL TREATMENT
REQUESTED) days from the date of the invoice(s), unless such invoice(s) are in
dispute, will result in BVL requiring Customer to pay all or part of the fee for
services in advance for future orders until such time as Customer has
reestablished its credit. In order to avoid penalty, Customer must notify BVL
within (CONFIDENTIAL TREATMENT REQUESTED) after receipt of invoice if invoice is
to be disputed.

8.2 Customer acknowledges that all prices of Product shall be on the basis of
(CONFIDENTIAL TREATMENT REQUESTED).

8.3 Customer may be asked to prepay a minimum of (CONFIDENTIAL TREATMENT
REQUESTED) of the amount of the Purchase Order with the Purchase Order, until
acceptable credit history is established.

8.4 BVL will consider that the Product has been accepted by Customer, unless BVL
is notified in writing within (CONFIDENTIAL TREATMENT REQUESTED) after shipment
of the completed batch record that the Product fails to conform to applicable
specifications.

8.5 Pricing will be established in Proposal/Quotations provided to Customer by
BVL.

9.     Cancellation or Postponement

9.1 Customer will pay a cancellation fee of (CONFIDENTIAL TREATMENT REQUESTED)
of the price of the quoted batch if cancellation or postponement is within
(CONFIDENTIAL TREATMENT REQUESTED) weeks of the scheduled manufacturing date. If
cancellation occurs within

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(CONFIDENTIAL TREATMENT REQUESTED) weeks of the scheduled fill date, Customer is
responsible for paying (CONFIDENTIAL TREATMENT REQUESTED) price of the scheduled
production.

10.   Storage

10.1 (CONFIDENTIAL TREATMENT REQUESTED) is responsible for storage charges for
Products stored more than one month beyond BVL's release. A formal quotation for
these charges may be obtained from (CONFIDENTIAL TREATMENT REQUESTED) Contract
Service Department. These charges are reviewed annually. Short term storage of
Product in BVL's warehousing facilities beyond one month must receive prior
approval from BVL. Such approval will be granted on a space-available basis.

11.   Stability Program

11.1 Customer is responsible for stability testing program. Customer may
contract with BVL to perform stability testing under separate proposals provided
to Customer by BVL based on a mutually agreed to protocol.

12.   Retention Samples

12.1 Customer is responsible for maintaining retention samples of all finished
Product shipped to Customer.

13.   Release for Sale and/or Distribution

13.1 Customer is responsible for release of the final Product for sale or
distribution.

14.   Complaints

14.1 Customer is responsible for maintaining complaint file and notifying BVL of
complaints relating to manufacturing defects.

15.   Regulatory

15.1 Customer is responsible for securing the necessary regulatory approvals for
the Product.

15.2 Customer is responsible for Drug Listing of Product and providing a copy of
Drug Establishment Regulatory Form 2656 to BVL once Product is approved by U.S.
FDA for marketing.

15.3 Customer will certify that the Product to be manufactured by BVL shall not
be processed, packed, or distributed in violation of any provision of the
Federal Food, Drug and Cosmetic Act.

15.4 Customer is responsible for all Product specific Agency(s) filings
including the Annual Report filing with the FDA.

15.5 Customer is responsible to insure that all filings with any agency are
consistent with the specifications for the Product contained in BVL's Master
Batch Record, BVL SOP's or incorporated by reference in these documents.

16.   Confidentiality

16.1 The terms of this Confidentiality section are mutual between BVL and
Customer as either a Disclosing Party or Receiving Party as the case may be.

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16.2 The Disclosing party will provide to the Receiving party certain
information including but not limited to, data, reports, patents, patent
applications, trade secrets, or the like concerning any scientific, technical,
financial, trade, or business information applicable to the project, the
Confidential Information. The Receiving party agrees to protect and keep
confidential all Confidential Information and all notes of information obtained
pursuant to this Agreement. The Receiving Party agrees that it shall limit its
use of the Confidential Information to performing certain services as mutually
agreed to in writing by the Parties. The Receiving Party also agrees that it
shall not use any Confidential Information, directly or indirectly, for its own
benefit or that of any person, firm or corporation other than the Disclosing
Party. All information exchanged regardless of format shall be considered
Confidential Information.

16.3 The Receiving Party agrees and acknowledges that the Confidential
Information to be disclosed to it pursuant to this Agreement constitutes unique
and valuable commercial and proprietary information of the Disclosing Party.
Accordingly, the Receiving Party shall not duplicate, disclose, or discuss any
such Confidential Information to or with third parties, without the prior
written consent of the Disclosing Party. Except that the Receiving Party may
disclose Confidential Information received by it under this Agreement only to
those of its directors, officers, employees, agents, and consultants who have a
need to know such Confidential Information in the course of the performance of
their duties with respect to the purposes of this Agreement and who are bound by
written agreement to protect the confidentiality of such Confidential
Information in accordance with the terms hereof.

16.4 Notwithstanding anything to the contrary herein, the Receiving Party shall
not be obligated to maintain the confidentiality of any information provided to
it under this Agreement which:

a. Is already in the public domain at the time of disclosure to it, or

b. at any time after disclosure to the Receiving Party becomes public knowledge
through no fault of the Receiving Party;

c. is disclosed to the Receiving Party by any third party who is free to make
such disclosure; or

d. is disclosed by the Receiving Party with the prior written consent of the
Disclosing Party, or

e. is information which the Receiving Party can establish was in it's possession
prior to disclosure or was subsequently and independently developed by employees
of or on behalf of the Receiving Party without use, direct or indirect, of
Confidential Information protected by this Agreement.

f. is required to be disclosed pursuant to a requirement of law, subject to
provisions outlined in Item 16.8 of Section 16 of this agreement.

16.5 The confidential undertakings and agreements of the Receiving Party shall
survive termination of this Agreement. Promptly upon termination of this
Agreement and request of the Disclosing Party, the Receiving Party shall return
to the Disclosing Party all notes of information obtained pursuant hereto and
summaries thereof and any copies of documents of the Disclosing Party, personnel
interviews, or other Confidential Information in its possession. This agreement
shall not be construed as a grant of any right or license to the Receiving Party
with respect to Confidential Information or the Disclosing Party's Product or as
a requirement to either party to enter into any further arrangement with respect
to Confidential Information or the Disclosing Party's Product.

16.6 The confidentiality obligations of this agreement shall be maintained for a
period of five years beyond the expiration or termination of this Agreement.

16.7 Provided all obligations of this agreement are maintained, the parties
understand and acknowledge that the other may now market or have under
development products which are competitive with products now offered or which
may be offered by the other, and the parties' communications hereunder will not
serve to impair the right of other to develop, make, use, procure, or market
products or services now or in the future which may be competitive to those
offered by the other party nor for the parties to disclose any planning or other
information to the other.

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16.8 Notwithstanding any provision herein to the contrary, in the event that any
Receiving Party hereafter becomes obligated by mandatory applicable law,
regulatory rule or judicial or administrative order to disclose Confidential
Information or any portion thereof, to any third party, governmental authority
or court, the Receiving Party shall immediately notify the Disclosing Party
thereof of each such requirement and identify the Confidential Information so
required thereby, so that the Disclosing Party may seek an appropriate
protective order or other remedy with respect to narrowing the scope of such
requirement and/or waive Receiving Party's compliance with the provisions of
this Agreement.

16.9 Both parties agree that should this Agreement be breached, money damages
would be inadequate to remedy such a breach. As a result, the non-breaching
party shall be entitled to seek, and a court of competent jurisdiction may
grant, specific performance and injunctive or other equitable relief as a remedy
for any such breach of this Agreement. Such remedy shall be in addition to all
other remedies, including money damages, available to a non-breaching party at
law or in equity.

16.10 Upon request, each party shall return all copies of the Confidential
Information to the other party, except for a single copy to be kept by it's
legal counsel in its confidential file for the purpose of determining compliance
with its obligations of this agreement.

16.11 Neither party will issue any press release or other public announcement
relating to any activities involving the other party without the prior written
consent of the other party, except where such announcements are required by law
or regulation. The parties will use all reasonable efforts to consult with the
other and cooperate with respect to wording of any such announcement.

17.   Batch Rejections

17.1 BVL will reserve the right to sample and retest Product if, prior to
Customer's release, Customer claims that Product fails to meet applicable
specifications.

17.2 Customer will provide an approved rework procedure (if Product can be
reworked).

17.3 In the event of a rejection of a batch of Product, BVL will cease further
production of Product until such time as the results of the investigation have
been communicated to Customer and Customer has confirmed the corrective action.
Should Customer desire to have Product manufactured while the investigation is
in process, (CONFIDENTIAL TREATMENT REQUESTED) will be responsible for the fees
for service performed by BVL whether the batch is accepted or rejected by
Customer or BVL. (CONFIDENTIAL TREATMENT REQUESTED) will provide a written
statement of financial responsibility (CONFIDENTIAL TREATMENT REQUESTED)
(CONFIDENTIAL TREATMENT REQUESTED) while investigations and corrective actions
are being determined by BVL and Customer.

17.4 Customer may reject any commercial, developmental or clinical Products
manufactured for Customer if such Products fail to comply with Manufacturing
Instructions and Specifications, incorporated in the master batch record,
previously agreed upon by Customer and Ben Venue. However, until such time as
all manufacturing processes and/or analytical procedures are validated,
(CONFIDENTIAL TREATMENT REQUESTED) will be financially responsible for all BVL
fees for services for each batch of Product provided by BVL, at prices confirmed
by quotation(s) and purchase orders, unless such batch is rejected due to the
gross negligence of BVL. Customer acknowledges that until all processes and
methods are validated that additional cost may be incurred for unanticipated
developmental issues.

18.   Term and Termination

18.1 This agreement remains in effect until superceded by a future agreement or
upon termination by either party.

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18.2 This agreement may be terminated by (CONFIDENTIAL TREATMENT REQUESTED) by
giving (CONFIDENTIAL TREATMENT REQUESTED) written notice to (CONFIDENTIAL
TREATMENT REQUESTED).

19.   Notices

19.1 All notices required or permitted hereunder shall be given in writing and
sent by mailed postage prepaid, certified or registered mail, return receipt
requested, or sent by a nationally recognized express courier service, or
hand-delivered at the following addresses:

If to Ben Venue:   Ben Venue Laboratories, Inc.
A Boehringer-Ingelheim Company
Attn: General Manager
Contract Manufacturing Services
300 Northfield Road
Bedford, Ohio 44146
Fax: 440-439-6398
If to COMPANY:
 
MedImmune, Inc.
Attn: Senior Director, Supply Chain Management
660 Research Drive
Frederick, MD 21703
Cc.
 
MedImmune, Inc.
Attn: Legal Affairs
35 West Watkins Mill Road
Gaithersburg, MD 20878

        Notices shall be effective upon receipt. A party may change its address
listed above by written notice to the other party.

20.   Amendments and Waiver of Provision

20.1 This Agreement may only be amended by a written instrument duly executed by
both parties.

20.2 No waiver of any provision of this Agreement shall be effective unless the
party whose rights are being waived duly executes it. No waiver with respect to
any one occurrence, action, or inaction shall be effective with respect to any
subsequent or other occurrence, action or inaction, similar or otherwise.

21.   Assignment

21.1 This Agreement may not be assigned by either party hereto EXCEPT to an
affiliate or a purchaser of all or substantially all of the stock or assets of
either one of the parties without the prior written consent of the other and
shall be binding upon and inure to the benefit of the successors and permitted
assigns of each party.

22.   Governing Law

22.1 This Agreement and the rights, duties and obligations of the parties
hereunder shall be governed by and construed in accordance with the laws of the
State of Delaware, USA.

23.   Miscellaneous

23.1 Customer will provide the name and phone numbers of a contact person(s) who
may be called at any hour during the times when BVL is manufacturing the
Product.

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23.2 Nothing contained in this Agreement shall be construed, by implication or
otherwise, as an obligation to enter into any further agreement relating to any
of the Confidential Information or as the grant of a license to either party to
use the other's Confidential Information other than for the purpose herein.

        These terms and conditions supersede any conflicting Terms and
Conditions contained with the Customer's Purchase Orders or on BVL's Purchase
Order acknowledgment. Customer acknowledges that these terms and conditions are
incorporated by reference on every purchase order.

THIS DOCUMENT SUPERSEDES ALL OTHER DOCUMENTS AND AGREEMENTS.

For BEN VENUE LABORATORIES, INC. (BVL)    
BY
 
/s/    Peter Hansbury, R. Ph.
        Peter Hansbury, R. Ph.
        General Manager, Contract Manufacturing Services
 
DATE: 10/17/2003
For: Customer
 
 
BY
 
/s/    Edward Goley
        Edward Goley
        Vice President and General Manager, Manufacturing
 
DATE: 10/16/2003

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