Exhibit 10.10

950 Winter Street
Waltham, MA 02451
Tel: (617) 551-4000
Fax: (617) 551-4701
February 20, 2015

Dinesh Purandare
18 Richmond Circle
Lexington, MA 02421

Dear Dinesh:

On behalf of Radius Health, Inc. (the "Company"), with offices at 950 Winter
Street, Waltham, MA, 02451, I am pleased to offer you full-time employment as
the Senior Vice President, Global Oncology/Commercial on the terms set forth
below. This letter agreement is subject to, and will become effective only upon,
your commencing employment with the Company on or about March 16, 2015 .

In the course of your employment with the Company, you will be subject to and
required to comply with all Company policies, and applicable laws and
regulations. The term "Agreement" as used below shall mean this letter
agreement.

Duties; Work Location

As Senior Vice President, Global Oncology/Commercial, you will report to the
Company's Chief Executive Officer and will have such duties and authority as are
normally associated with such position or as may from time to time be assigned
to you by the Board of Directors of Company or an authorized committee (the
"Board"). The Company requires that, as a full-time employee, you devote your
full business time, attention, skill, and efforts to the tasks and duties of
your position with the Company. Your normal place of work will initially be the
Company's Waltham, Massachusetts offices; however, your duties may require
reasonable business travel as determined by the Chief Executive Officer.

Cash Compensation

You will earn a salary at the semi-monthly rate of $14,791.66, annualized at a
rate of $355,000, or such greater amount as is subsequently determined by the
Board (the "Annual Base Salary"). All compensation amounts payable pursuant to
this Agreement shall be subject to all applicable tax and other withholdings.

In addition, subject to approval of the Board, you will be eligible for an
annual discretionary bonus (your "Annual Bonus"), which Annual Bonus shall be
targeted at 35% (your "Target") of your annualized base salary, subject to
pro-ration during any year in which you are employed for less than the full
year. The Board also has the discretion to award a bonus in excess of your
Annual Target Bonus for exemplary performance. Any Annual Bonus will be based on
both individual and corporate performance and the amount of any such Annual
Bonus will be determined by the Company. Annual Bonuses shall be paid to you
when generally paid to other senior executives of the Company, subject to your
continued employment through the payment date.

You will also be entitled to reimbursement of all business expenses reasonably
incurred in connection with the performance of your functions and duties under
this Agreement, subject to the Company's expense reimbursement policy in effect
from time to time.

Equity Incentive

Subject to approval by the Board after the commencement of your employment, the
Company will grant to you an initial stock option (the "Initial Option") under
the Radius Health, Inc. 2011 Equity Incentive Plan (the "Plan") for the purchase
of 115,000 shares (subject to appropriate adjustment in the event of any stock
split, stock dividend or other similar event) of common stock of the Company
("Common Stock") at a price per share equal to the Common Stock's closing price
on the NASDAQ Global Market on the date of grant. The Initial Option shall be
subject to all terms and other provisions set forth in the Plan and in a

--------------------------------------------------------------------------------

2

separate option agreement and will vest as to 25% of the underlying shares on
the first anniversary of the date you commence employment with the Company and
in quarterly installments over the following three years.

Benefits

You will be eligible to participate in all of the employee benefits and benefit
plans that the Company generally makes available to its similarly situated
full-time regular employees, including group health plans, life, disability and
AD&D insurances, a 401 (k) plan with Company match, tuition reimbursement, and
various types of paid time off, subject to the terms and conditions of such
benefits and plans. You will be eligible to accrue up to 20 days of vacation (in
addition to Company holidays), which will accrue over the first year of your
employment and may be used with the advance approval of the Chief Executive
Officer. The Company reserves the right to terminate, modify or add to its
benefits and benefit plans at any time.

Term and Termination

This Agreement shall commence on your first day of your employment with the
Company and may be terminated at any time by you or by the Company with or
without cause. You and the Company acknowledge and agree that your employment is
and shall continue to be at-will and that nothing in this Agreement shall confer
upon you any right with respect to continuation of employment by the Company,
nor shall it interfere in any way with your right or the Company's right to
terminate your employment at any time.

As you are aware, the Company is in the process of standardizing its executive
termination pay arrangements. On or prior to your commencing employment, you and
the Company will enter into an executive severance agreement (the "Severance
Agreement") that governs the payments and benefits you may receive upon a
termination of your employment with the Company. Except as otherwise provided in
the Severance Agreement, the Company's obligations to you under this Agreement
will cease upon your termination of employment for any reason. The Severance
Agreement will include substantially the same terms as are offered to other
similarly situated Company executives and is currently expected to provide,
generally, for the following termination payments and benefits:

•
upon your termination of employment for any reason, payment of (i) any earned
but unpaid base salary, (ii) any accrued but unpaid paid time off and (iii) any
other amounts or benefits, if any, under the Company's employee benefit plans to
which you are entitled pursuant to the terms of such plans, payable in
accordance with the terms of such plans or as otherwise required by applicable
law (collectively, the "Accrued Rights");

•
upon a termination of your employment by the Company without "cause" or by you
for "good reason" that does not occur within 12 months following a Change of
Control (as defined in the Plan), in addition to the Accrued Rights, and
provided that you timely execute (and do not revoke) a release of claims in the
Company's favor, payment of (i) 6 months of base salary and (ii) 6 months of
healthcare insurance benefits continuation; and

•
upon a termination of your employment by the Company without "cause" or by you
for "good reason" that occurs within 12 months following a Change of Control (as
defined in the Plan), in addition to the Accrued Rights, and provided that you
timely execute (and do not revoke) a release of claims in the Company's favor,
payment of (i) 12 months of base salary, (ii) an amount equal to your target
annual bonus for the year of termination, (iii) 12 months of healthcare
insurance benefits continuation and (iv) full accelerated vesting of Company
equity awards, provided that the foregoing will be subject to reduction (to the
minimum extent necessary) if doing so would result in you receiving a greater
amount on an after-tax basis due to application of Sections 280G and 4999 of the
Internal Revenue Code.

Contingencies

This offer, and any employment pursuant to this offer, is conditioned upon the
following:

•
Your ability to provide satisfactory documentary proof of your identity and
right to work in the United States of America prior to your commencement of
employment by the Company.

•
Your return of the enclosed copy of this letter and the Company's standard
Confidentiality and Non-Competition Agreement. By signing and accepting this
offer, you represent and warrant that you are not subject to any pre-existing
contractual or other legal obligation with any person, company or business
enterprise which may be an impediment to your employment with, or your providing
services to, the Company as its employee.

Successors

This Agreement is personal to you and without the prior written consent of the
Company you shall not assign your obligations under this Agreement, otherwise
than by will or the laws of descent and distribution. This Agreement shall inure
to the benefit

--------------------------------------------------------------------------------

3

of and be enforceable by your legal representatives.

This Agreement shall inure to the benefit of and be binding upon the Company and
its successors and assigns, provided that the Company may not assign this
Agreement other than as described below.

Applicable Law

This Agreement has been made under and shall be construed and enforced in
accordance with the laws of the Commonwealth of Massachusetts, disregarding any
choice of law rules that would result in the application of the laws of another
jurisdiction.

Notice

Any notice, statement or demand required to be given under this Agreement shall
be in writing and shall be sent by hand delivery against receipt, certified
mail, return receipt requested or by a nationally recognized overnight carrier
to the address of the parties first listed above or such other address as either
party subsequently provides to the other in accordance with the provisions of
this paragraph.

Waiver

The failure of either party to insist upon strict performance of any of the
terms or provisions of this Agreement or to exercise any option, right or remedy
contained in this Agreement, shall not be construed as a waiver or as a
relinquishment for the future of such term, provision, option, right or remedy,
but the same shall continue and remain in full force and effect. No waiver by
either party of any term or provision of this Agreement shall be deemed to have
been made unless expressed in writing and signed by such party.

Entire Agreement

If you accept this offer, this Agreement and the Confidentiality and
Non-Competition Agreement shall constitute the complete agreement between you
and the Company with respect to the terms and conditions of your employment. Any
prior or contemporaneous representations (whether oral or written) not contained
in this Agreement or the Confidentiality and Non-Competition Agreement or
contrary to those contained in this Agreement or the Confidentiality and
Non-Competition Agreement that may have been made to you are expressly cancelled
and superseded by this offer. Except as otherwise specified herein, the terms
and conditions of your employment may not be changed, except in another written
agreement, signed by you and an authorized representative of the Company.

To indicate your acceptance of this offer, please return a countersigned copy of
this offer to me within five (5) business days from the date hereof, after which
time this offer will automatically expire.
I look forward to you accepting this offer and to a mutually rewarding
relationship.

Best Regards,

/s/ Linda A. Damon

Linda A. Damon
Head of Human Resources

I accept the above-described Agreement, on the terms set forth therein.

Dated: December 29, 2014
/s/ Dinesh Purandare
 
Dinesh Purandare