Repository: AlexandrovLab/SigProfilerAssignment (language: python)

Issue:
flag make_decomposition_plots from SPE



Discussion / hints:

Fix patch:
diff --git a/.gitignore b/.gitignore
index 2b32c16..3946b60 100644
--- a/.gitignore
+++ b/.gitignore
@@ -54,8 +54,8 @@ cover/
 SigProfilerAssignment/data/tests/vcf_input/input/
 SigProfilerAssignment/data/tests/vcf_input/logs/
 SigProfilerAssignment/data/tests/vcf_input/output/
-output_vcf_example/
-output_txt_example/
+SigProfilerAssignment/DecompositionPlots/CosmicTemplates/
+TestOutput/
 
 
 
diff --git a/.travis.yml b/.travis.yml
index e54ac3c..658e679 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -1,6 +1,9 @@
 dist: xenial
 language: python
 
+vm:
+  size: large
+
 python:
   - '3.8'
 
diff --git a/MANIFEST.in b/MANIFEST.in
index 621a17f..18d81ed 100644
--- a/MANIFEST.in
+++ b/MANIFEST.in
@@ -1,13 +1,12 @@
 include README.md
 include SigProfilerAssignment/data/*
-include SigProfilerAssignment/data/vcftest/*
 include SigProfilerAssignment/data/Reference_Signatures/GRCh37/*
 include SigProfilerAssignment/data/Reference_Signatures/GRCh38/*
 include SigProfilerAssignment/data/Reference_Signatures/mm9/*
 include SigProfilerAssignment/data/Reference_Signatures/mm10/*
 include SigProfilerAssignment/data/Reference_Signatures/rn6/*
-include SigProfilerAssignment/DecompositionPlots/reference_files/Fonts/*
-include SigProfilerAssignment/DecompositionPlots/reference_files/*
+include SigProfilerAssignment/DecompositionPlots/ReferenceFiles/Fonts/*
+include SigProfilerAssignment/DecompositionPlots/ReferenceFiles/*
 include SigProfilerAssignment/DecompositionPlots/*
 include SigProfilerAssignment/data/tests/vcf_input/*
 include SigProfilerAssignment/data/tests/txt_input/*
diff --git a/SigProfilerAssignment/Analyzer.py b/SigProfilerAssignment/Analyzer.py
index 9fd8bf3..dd458e6 100644
--- a/SigProfilerAssignment/Analyzer.py
+++ b/SigProfilerAssignment/Analyzer.py
@@ -7,5 +7,5 @@ def decompose_fit(samples, output, signatures=None, signature_database=None,nnls
 def denovo_fit(samples,  output, signatures=None, signature_database=None,nnls_add_penalty=0.05,nnls_remove_penalty=0.01, initial_remove_penalty=0.05, genome_build="GRCh37", cosmic_version=3.3, make_plots=True, collapse_to_SBS96=True,connected_sigs=True, verbose=False,devopts=None,new_signature_thresh_hold=0.8,exome=False,input_type='matrix',context_type="96",export_probabilities=True, export_probabilities_per_mutation=False):
                 decomp.spa_analyze(samples=samples,  output=output, signatures=signatures, signature_database=signature_database,nnls_add_penalty=nnls_add_penalty, nnls_remove_penalty=nnls_remove_penalty, initial_remove_penalty=initial_remove_penalty,genome_build=genome_build, cosmic_version=cosmic_version, new_signature_thresh_hold=new_signature_thresh_hold, make_plots=make_plots, collapse_to_SBS96=collapse_to_SBS96,connected_sigs=connected_sigs, verbose=verbose,decompose_fit_option= False,denovo_refit_option=True,cosmic_fit_option=False,devopts=devopts,exome=exome,input_type=input_type,context_type=context_type,export_probabilities=export_probabilities, export_probabilities_per_mutation=export_probabilities_per_mutation)
 
-def cosmic_fit(samples, output, signatures=None, signature_database=None,nnls_add_penalty=0.05, nnls_remove_penalty=0.01, initial_remove_penalty=0.05,genome_build="GRCh37", cosmic_version=3.3, make_plots=True, collapse_to_SBS96=True,connected_sigs=True, verbose=False,devopts=None,exclude_signature_subgroups=None,exome=False,input_type='matrix',context_type="96",export_probabilities=True, export_probabilities_per_mutation=False):
-                decomp.spa_analyze(samples=samples,  output=output, signatures=signatures, signature_database=signature_database,nnls_add_penalty=nnls_add_penalty, nnls_remove_penalty=nnls_remove_penalty, initial_remove_penalty=initial_remove_penalty,genome_build=genome_build, cosmic_version=cosmic_version, make_plots=make_plots, collapse_to_SBS96=collapse_to_SBS96,connected_sigs=connected_sigs, verbose=verbose,decompose_fit_option= False,denovo_refit_option=False,cosmic_fit_option=True,devopts=devopts,exclude_signature_subgroups=exclude_signature_subgroups,exome=exome,input_type=input_type,context_type=context_type,export_probabilities=export_probabilities, export_probabilities_per_mutation=export_probabilities_per_mutation)
\ No newline at end of file
+def cosmic_fit(samples, output, signatures=None, signature_database=None,nnls_add_penalty=0.05, nnls_remove_penalty=0.01, initial_remove_penalty=0.05,genome_build="GRCh37", cosmic_version=3.3, make_plots=True, collapse_to_SBS96=True,connected_sigs=True, verbose=False,devopts=None,exclude_signature_subgroups=None,exome=False,input_type='matrix',context_type="96",export_probabilities=True, export_probabilities_per_mutation=False, sample_reconstruction_plots=False):
+                decomp.spa_analyze(samples=samples,  output=output, signatures=signatures, signature_database=signature_database,nnls_add_penalty=nnls_add_penalty, nnls_remove_penalty=nnls_remove_penalty, initial_remove_penalty=initial_remove_penalty,genome_build=genome_build, cosmic_version=cosmic_version, make_plots=make_plots, collapse_to_SBS96=collapse_to_SBS96,connected_sigs=connected_sigs, verbose=verbose,decompose_fit_option= False,denovo_refit_option=False,cosmic_fit_option=True,devopts=devopts,exclude_signature_subgroups=exclude_signature_subgroups,exome=exome,input_type=input_type,context_type=context_type,export_probabilities=export_probabilities, export_probabilities_per_mutation=export_probabilities_per_mutation, sample_reconstruction_plots=sample_reconstruction_plots)
diff --git a/SigProfilerAssignment/DecompositionPlots/ExampleSample/CNV48_De-Novo_Signatures.txt b/SigProfilerAssignment/DecompositionPlots/ExampleSample/CNV48_De-Novo_Signatures.txt
new file mode 100644
index 0000000..1aaddcf
--- /dev/null
+++ b/SigProfilerAssignment/DecompositionPlots/ExampleSample/CNV48_De-Novo_Signatures.txt
@@ -0,0 +1,49 @@
+MutationType	CNV48A	CNV48B	CNV48C	CNV48D	CNV48E
+0:homdel:0-100kb	0.00000083	0.00000295	0.00227050	0.00000075	0.00096858
+0:homdel:100kb-1Mb	0.00410855	0.00039561	0.00207384	0.02703219	0.00559786
+0:homdel:>1Mb	0.00000554	0.00122668	0.00000000	0.02703635	0.00696978
+1:LOH:0-100kb	0.00112830	0.00000063	0.01226193	0.00000000	0.00708714
+1:LOH:100kb-1Mb	0.00000391	0.01552501	0.00613728	0.03899750	0.03144637
+1:LOH:1Mb-10Mb	0.00401818	0.00000253	0.00000093	0.14062679	0.07397784
+1:LOH:10Mb-40Mb	0.00005266	0.00000012	0.00000048	0.10997624	0.04210990
+1:LOH:>40Mb	0.00000102	0.00000124	0.00000247	0.00002991	0.13316480
+2:LOH:0-100kb	0.00455813	0.00000060	0.00401138	0.01406873	0.00522486
+2:LOH:100kb-1Mb	0.00000259	0.01066978	0.04899240	0.00456627	0.00313024
+2:LOH:1Mb-10Mb	0.00019789	0.08507254	0.02222360	0.09357127	0.00935381
+2:LOH:10Mb-40Mb	0.00000000	0.08543525	0.04039981	0.08964456	0.00120907
+2:LOH:>40Mb	0.04000652	0.03252400	0.00482349	0.07308834	0.00000109
+3-4:LOH:0-100kb	0.00000000	0.00062965	0.00486737	0.00402011	0.00000348
+3-4:LOH:100kb-1Mb	0.00000000	0.02211930	0.00352244	0.01443590	0.00000289
+3-4:LOH:1Mb-10Mb	0.01154405	0.04058766	0.00000179	0.04505698	0.00000080
+3-4:LOH:10Mb-40Mb	0.00000431	0.01798391	0.03246762	0.01713715	0.00000000
+3-4:LOH:>40Mb	0.00010679	0.03244896	0.00503232	0.00000456	0.00000196
+5-8:LOH:0-100kb	0.00412411	0.00000286	0.00000075	0.00540728	0.00213831
+5-8:LOH:100kb-1Mb	0.00000000	0.01173257	0.00575306	0.00000030	0.00000283
+5-8:LOH:1Mb-10Mb	0.00831646	0.01147780	0.01165105	0.00003824	0.00000276
+5-8:LOH:10Mb-40Mb	0.00000041	0.00521012	0.00000159	0.00843632	0.00000427
+5-8:LOH:>40Mb	0.00082246	0.00295490	0.00000154	0.00000174	0.00000358
+9+:LOH:0-100kb	0.00000189	0.01177812	0.00000083	0.01804860	0.00002121
+9+:LOH:100kb-1Mb	0.00000000	0.00492384	0.00080071	0.00000000	0.00486780
+9+:LOH:1Mb-10Mb	0.00000000	0.01272578	0.00000243	0.00001046	0.00213166
+9+:LOH:10Mb-40Mb	0.00000168	0.00000432	0.00000648	0.00000194	0.00000654
+9+:LOH:>40Mb	0.00000168	0.00000432	0.00000648	0.00000194	0.00000654
+2:het:0-100kb	0.00424056	0.00000053	0.00183007	0.00000000	0.00545910
+2:het:100kb-1Mb	0.00000025	0.00000105	0.00494850	0.03848499	0.04887068
+2:het:1Mb-10Mb	0.02097226	0.00756213	0.00000000	0.00000012	0.12582459
+2:het:10Mb-40Mb	0.01623286	0.00846561	0.00877833	0.00000000	0.14361308
+2:het:>40Mb	0.00000046	0.00000128	0.00000645	0.00000556	0.32189335
+3-4:het:0-100kb	0.00000335	0.00000000	0.03500289	0.00305884	0.00017426
+3-4:het:100kb-1Mb	0.03277032	0.00000000	0.14771851	0.04636413	0.02342268
+3-4:het:1Mb-10Mb	0.47610782	0.00000132	0.00000610	0.07745060	0.00000115
+3-4:het:10Mb-40Mb	0.05013614	0.30243415	0.06416661	0.00749927	0.00000000
+3-4:het:>40Mb	0.00000735	0.00000731	0.46907268	0.00000069	0.00000308
+5-8:het:0-100kb	0.01322548	0.00000000	0.00611310	0.00000070	0.00000266
+5-8:het:100kb-1Mb	0.03631060	0.00000958	0.01778273	0.07310104	0.00000113
+5-8:het:1Mb-10Mb	0.20339816	0.09416172	0.00008219	0.00000176	0.00000000
+5-8:het:10Mb-40Mb	0.00006818	0.16540860	0.00001318	0.00000155	0.00000200
+5-8:het:>40Mb	0.01074217	0.00131701	0.01877488	0.00000803	0.00000051
+9+:het:0-100kb	0.00534523	0.00000160	0.00239221	0.00000048	0.00127719
+9+:het:100kb-1Mb	0.04305627	0.00000063	0.00095669	0.00312988	0.00000363
+9+:het:1Mb-10Mb	0.00000000	0.01518129	0.01502529	0.01964883	0.00000520
+9+:het:10Mb-40Mb	0.00837288	0.00000088	0.00000859	0.00000119	0.00000306
+9+:het:>40Mb	0.00000168	0.00000432	0.00000648	0.00000194	0.00000654
diff --git a/SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_CNV48_Signatures.txt b/SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_CNV48_Signatures.txt
new file mode 100644
index 0000000..e65d60d
--- /dev/null
+++ b/SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_CNV48_Signatures.txt
@@ -0,0 +1,49 @@
+MutationType	CN1	CN2	CN9	CN20	CNV48B	CNV48D
+0:homdel:0-100kb	0.00179505	0.00223767	0.00818184	0.00004078	0.00000295	0.00000075
+0:homdel:100kb-1Mb	0.00380710	0.00719579	0.02099919	0.00017845	0.00039561	0.02703219
+0:homdel:>1Mb	0.00243675	0.00383711	0.00900922	0.00011722	0.00122668	0.02703635
+1:LOH:0-100kb	0.00284045	0.00282654	0.01858365	0.00050182	0.00000063	0.00000000
+1:LOH:100kb-1Mb	0.01226306	0.00632391	0.13080787	0.00081924	0.01552501	0.03899750
+1:LOH:1Mb-10Mb	0.01916342	0.00102376	0.15994920	0.00624116	0.00000253	0.14062679
+1:LOH:10Mb-40Mb	0.04729776	0.00048336	0.07622936	0.00283775	0.00000012	0.10997624
+1:LOH:>40Mb	0.07364600	0.00012432	0.02700069	0.00001202	0.00000124	0.00002991
+2:LOH:0-100kb	0.00118798	0.00248892	0.00411906	0.00060974	0.00000060	0.01406873
+2:LOH:100kb-1Mb	0.00430310	0.01946487	0.01377423	0.00134094	0.01066978	0.00456627
+2:LOH:1Mb-10Mb	0.00443801	0.03355154	0.01159439	0.01443458	0.08507254	0.09357127
+2:LOH:10Mb-40Mb	0.00431859	0.05229117	0.00494515	0.00966270	0.08543525	0.08964456
+2:LOH:>40Mb	0.01221565	0.06737476	0.00240730	0.00049936	0.03252400	0.07308834
+3-4:LOH:0-100kb	0.00137995	0.00271740	0.00183353	0.00256100	0.00062965	0.00402011
+3-4:LOH:100kb-1Mb	0.00166785	0.01381945	0.00284860	0.02182453	0.02211930	0.01443590
+3-4:LOH:1Mb-10Mb	0.00151428	0.01247139	0.00344351	0.02055562	0.04058766	0.04505698
+3-4:LOH:10Mb-40Mb	0.00010220	0.01063124	0.00139001	0.00224340	0.01798391	0.01713715
+3-4:LOH:>40Mb	0.00736761	0.01742692	0.00119860	0.00094554	0.03244896	0.00000456
+5-8:LOH:0-100kb	0.00035130	0.00168941	0.00037594	0.00091844	0.00000286	0.00540728
+5-8:LOH:100kb-1Mb	0.00021211	0.00341625	0.00083617	0.00241053	0.01173257	0.00000030
+5-8:LOH:1Mb-10Mb	0.00020778	0.00449531	0.00066162	0.00524955	0.01147780	0.00003824
+5-8:LOH:10Mb-40Mb	0.00009972	0.00275604	0.00037649	0.00029923	0.00521012	0.00843632
+5-8:LOH:>40Mb	0.00033194	0.01008962	0.00038263	0.00012116	0.00295490	0.00000174
+9+:LOH:0-100kb	0.00013399	0.00052020	0.00075942	0.00014531	0.01177812	0.01804860
+9+:LOH:100kb-1Mb	0.00041199	0.00066864	0.00123437	0.00085741	0.00492384	0.00000000
+9+:LOH:1Mb-10Mb	0.00020077	0.00082900	0.00057456	0.00046208	0.01272578	0.00001046
+9+:LOH:10Mb-40Mb	0.00000651	0.00035090	0.00001019	0.00010940	0.00000432	0.00000194
+9+:LOH:>40Mb	0.00000276	0.00071277	0.00000455	0.00001071	0.00000432	0.00000194
+2:het:0-100kb	0.00012686	0.00107728	0.00281376	0.00053199	0.00000053	0.00000000
+2:het:100kb-1Mb	0.00239269	0.00144857	0.05745673	0.00464189	0.00000105	0.03848499
+2:het:1Mb-10Mb	0.01722643	0.00057147	0.15992032	0.00278654	0.00756213	0.00000012
+2:het:10Mb-40Mb	0.11204389	0.00040127	0.12954364	0.00139670	0.00846561	0.00000000
+2:het:>40Mb	0.64754824	0.00000162	0.00676787	0.00000815	0.00000128	0.00000556
+3-4:het:0-100kb	0.00098644	0.00130161	0.00668678	0.00077956	0.00000000	0.00305884
+3-4:het:100kb-1Mb	0.00362315	0.01521748	0.06747132	0.08651517	0.00000000	0.04636413
+3-4:het:1Mb-10Mb	0.00173459	0.05815643	0.04351086	0.33498798	0.00000132	0.07745060
+3-4:het:10Mb-40Mb	0.00300954	0.13520088	0.00753038	0.16201175	0.30243415	0.00749927
+3-4:het:>40Mb	0.00537392	0.39028478	0.00287618	0.00119273	0.00000731	0.00000069
+5-8:het:0-100kb	0.00074121	0.00171720	0.00171967	0.01515300	0.00000000	0.00000070
+5-8:het:100kb-1Mb	0.00011638	0.01163041	0.00135021	0.14454268	0.00000958	0.07310104
+5-8:het:1Mb-10Mb	0.00020400	0.01933555	0.00113611	0.10976846	0.09416172	0.00000176
+5-8:het:10Mb-40Mb	0.00001935	0.02564167	0.00046809	0.01800115	0.16540860	0.00000155
+5-8:het:>40Mb	0.00052566	0.04417481	0.00041355	0.00182344	0.00131701	0.00000803
+9+:het:0-100kb	0.00010526	0.00099145	0.00168183	0.00357070	0.00000160	0.00000048
+9+:het:100kb-1Mb	0.00031818	0.00324101	0.00425206	0.00971177	0.00000063	0.00312988
+9+:het:1Mb-10Mb	0.00018704	0.00377986	0.00080882	0.00568101	0.01518129	0.01964883
+9+:het:10Mb-40Mb	0.00000174	0.00190840	0.00003117	0.00085042	0.00000088	0.00000119
+9+:het:>40Mb	0.00001176	0.00209996	0.00002929	0.00003526	0.00000432	0.00000194
diff --git a/SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_DBS78_Signatures.txt b/SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_DBS78_Signatures.txt
new file mode 100644
index 0000000..d9f5dc2
--- /dev/null
+++ b/SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_DBS78_Signatures.txt
@@ -0,0 +1,79 @@
+MutationType	DBS1	DBS2	DBS3	DBS4	DBS5	DBS6	DBS7	DBS8	DBS9	DBS10	DBS11
+AC>CA	5.01701937314426e-05	0.00037763192433099	0.00633751919816087	0.0041466645172504	0.00214198792883815	0.00266518526451099	0.0459320112885566	0.215131968007548	0.0246556888496588	0.00958964366413706	0.00137721183664123
+AC>CG	2.66497608553337e-05	3.20078395756481e-05	4.64086051518866e-05	4.96798454240629e-05	0.00046242916968375	0.000146284604743836	0.00625435883558777	0.000973597231959742	0.0020746860129591	1.76258248032425e-05	0.000195021238181313
+AC>CT	0.00433058613899172	0.000127223589480494	0.00301406424857415	8.33339342597184e-18	0.00202187645619302	0.000240467843414526	0.013609484826239	0.318195189890234	0.0285645175697268	0.0134434256973884	0.000759979670438519
+AC>GA	0.00012820150108437	0.000239301513546644	0.00583850193846317	0.00440708306181203	0.000558518347799854	0.00859672540206928	0.00973678583524305	0.00116071201343607	0.0253572734917223	0.00532757981340948	0.000444326738536805
+AC>GG	5.76402024560437e-05	4.21049498518778e-18	0.000449115533727935	7.02128460529598e-18	1.11103112196745e-17	0.000104202732146294	0.00254177143078287	0.00081049718179588	0.00714614071130357	0.000587527493441419	0.0022618442572575
+AC>GT	0.00298800348984044	0.000282719087734432	0.0100801486458937	1.12180296118852e-08	0.000822763587619139	0.000132257313877989	0.00450313836162319	0.000151092684507627	0.0121273916699542	0.0285797272233369	0.00574005809286235
+AC>TA	0.00121135276615153	0.00149437232088199	0.00100801486458937	0.00127204442920484	0.00148137482928993	0.0101196884103613	0.00542377998222172	0.0124076111781097	0.0412932675043067	0.000104559977646354	0.00026538972618488
+AC>TG	0.000173627229815052	6.42176213568208e-06	1.1078183165289e-17	5.3185479677777e-05	0.00112104041135454	0.000449875257054674	0.000998696018866657	0.00257157747804372	0.0179405215613371	7.62789932162927e-06	0.000240258123326463
+AC>TT	0.0267507069191796	0.00294835620065907	1.77650144452383e-06	0.000161259175670849	0.00747693917215933	0.00318619892524246	0.00118082294815897	0.00026816449965592	0.0445005115823111	0.000707024610751539	0.00283484480242939
+AT>CA	0.000484052925155735	3.79704129765047e-05	0.00698995923811002	0.000912747084583705	0.000107543315783846	0.000113633671650282	0.0110505063255381	2.76737305155497e-05	0.0126631623811337	0.00349709402696314	0.00948079897599927
+AT>CC	0.000298264976703845	4.18879952677314e-18	0.00901545879006234	6.97514147607635e-18	2.12099317240363e-05	6.36946633197634e-05	0.00623208735115937	0.000142350484306605	0.00177483693215891	0.00114918670574427	0.00190016013232053
+AT>CG	3.99695153966769e-06	4.18879952677314e-18	0.0144962222835804	9.42640548052605e-18	1.04556001456517e-17	1.81415160003082e-06	0.00110505063255381	0.000264791809968928	9.19325646882309e-18	0.00256585652403245	1.74014664749354e-05
+AT>GA	0.00212902946334057	0.000168757391006687	0.00179713440638908	0.000322849405464106	0.00110530630111175	0.00161479428134611	0.0143357919898874	0.000161264185018671	0.00635152317856866	7.98486624853342e-05	0.0112009439378894
+AT>GC	0.000174741097462859	5.87637343684001e-06	0.00521268267046557	1.75374985684206e-05	1.04556001456517e-17	1.71447294068846e-05	0.00924857691569817	0.000224973492680368	0.00180474991416158	0.00404196703399706	0.00418035229110517
+AT>TA	0.0023499664831212	0.000460064792149184	0.00233329605249411	0.0045139129838037	0.000789646753857315	0.00219293050553176	0.0338483977539007	0.000313569248647416	0.00917331448082131	0.00290268711019887	0.0038403236358478
+CC>AA	1.05918794343151e-05	0.723624795251583	0.00898022503796504	6.94023815301923e-18	1.04032807495661e-17	8.23192932638496e-18	8.95465754871779e-18	0.0377371623225475	8.94883179785459e-18	0.0135043760749618	7.3138372596909e-18
+CC>AG	1.22905770794412e-05	0.0725623758774377	1.09659513664919e-17	0.00538364188155635	0.0240761640204245	0.0610948007837727	8.22164354583603e-05	0.0153523888713776	0.0261917028229891	7.02818988426843e-05	0.000967217662097899
+CC>AT	0.0186856740963861	0.0999481761397214	0.00581886968906645	0.0155659627146288	0.00240761640204245	0.000434407836741761	0.000843956662777386	0.0285257289997209	0.0193461441306169	0.0103500692545328	0.0343302565250797
+CC>GA	0.000133897343792286	0.0176908271767307	0.000627331452047062	0.00351969220617404	6.69773122543496e-05	0.0352088543477911	0.000299148957932828	0.000801295651415775	0.0109132095095787	0.003341593787892	0.000948311144011622
+CC>GG	9.81247698537496e-05	0.000449766792628746	7.16244571234835e-05	7.23767693100577e-05	1.17903848495083e-05	0.0179515567238034	0.00203064689987517	5.54666952772353e-05	0.00303585646357373	7.30419173105597e-18	0.00343302565250797
+CC>GT	0.00691469864957177	0.00109942993753694	1.12623284304512e-17	7.9217861203748e-05	2.45715583418324e-05	0.00341178757623666	0.000161461192526659	0.000226819164615837	0.0177587682019509	0.00106457855189479	0.0691580529997983
+CC>TA	0.0103920326525356	0.0159917081823554	0.0205488097678408	0.000168548640859039	0.00125830157637609	0.00220179314512947	8.95465754871779e-18	0.000709181318187509	0.000681579539370964	0.0235587290650793	0.0585106980775272
+CC>TG	0.00254804646768902	0.00023687717745114	2.86497828493934e-05	8.22913952429423e-06	0.0047656933719441	0.00681365716533309	0.000233772033351482	0.00416990691280643	0.0153777043089519	7.30419173105597e-18	0.0321410807466688
+CC>TT	0.857342693834187	4.16783894502638e-18	1.09659513664919e-17	6.94023815301923e-18	1.04032807495661e-17	8.23192932638496e-18	8.95465754871779e-18	0.0043382879520409	8.94883179785459e-18	0.0203058501565119	0.330366526560188
+CG>AT	6.16653830871348e-07	0.0011763313521222	0.000287143265528763	0.000294260040001608	0.0016629600883285	0.00765335476312575	6.2954837882978e-05	0.000326405219050766	0.000222362158326074	7.47530854576301e-18	0.00185347315330616
+CG>GC	5.54272597565955e-06	0.000377448929507038	1.12228529836946e-17	5.17491794485586e-06	0.000100588805342797	0.000598869935045648	0.000189574149502687	1.1454593090912e-17	1.21842278534835e-05	1.91674578096487e-05	0.000169053045851
+CG>GT	1.73849338719949e-06	0.00130930793975341	1.12228529836946e-17	7.10282855176294e-18	0.00657072034900529	0.00326840879804575	2.09849459609927e-05	0.00122655377345164	0.000100926020719688	1.02898984030746e-05	0.00120170237412157
+CG>TA	0.000364060968142951	4.26547977247791e-18	0.0989835411805136	7.10282855176294e-18	1.06470005655178e-17	8.4247804421676e-18	9.16444016847213e-18	0.000512922487079774	9.15847793653509e-18	0.361155257676539	7.51573179747221e-18
+CG>TC	1.28853039286551e-05	0.00219922818005455	0.000729990977858334	7.10282855176294e-18	3.02172016049935e-05	0.00904395105297751	4.93703801111276e-05	0.000917381128077462	0.000135041858709442	0.00267335595766154	0.000697598412095998
+CG>TT	0.000126807752948668	0.00568730636330387	0.00724935638676489	0.000366303015312347	0.00225108011956663	0.0189811318395824	3.17308603178295e-05	0.000333500984682303	8.41727074211485e-05	0.00783848143057741	0.000711855897890661
+CT>AA	2.7933194990298e-05	0.00323782659890067	0.000102691439563387	7.00403091014318e-18	0.465951395764967	0.00448409944446993	9.036966293971e-18	0.0205913663412117	9.03108699441082e-18	0.00390949072973925	0.00441859615813218
+CT>AC	0.000422527389925446	4.20614857240368e-18	0.0290128241873257	7.00403091014318e-18	0.208978201104889	0.0019517843564099	1.00966105718039e-17	0.0139941324649011	9.03108699441082e-18	0.0129321576301807	0.00235993203900241
+CT>AG	2.8739929863664e-18	0.000592088540048191	0.11365848650705	0.000363209031483139	0.0266972151650743	0.0395361446554826	0.00125957716044286	0.0203914501631417	0.000582715369262427	0.0263617059384453	0.000498096294189446
+CT>GA	8.99509383803096e-05	1.82569038754212e-05	1.7148473402818e-05	0.000673387543218051	0.0160983207549699	0.00734671650053777	0.00186937245240329	0.00556766555924998	0.00284349080533555	7.37132984920301e-18	0.0116490262350758
+CT>GC	0.000254121485110291	0.000135161608801461	2.68194147985932e-05	7.22415759589054e-05	0.0048494941404723	0.00179163794767884	0.0155947648435783	0.00023690067101297	0.00311382267767379	7.37132984920301e-18	0.00613582330140627
+CT>GG	1.08909207904411e-05	9.05784512714267e-05	5.97205556295812e-05	0.000926533231827512	0.000569940548467878	0.0068162315216161	0.00399865765219956	0.000305871752447126	0.0104127832308063	7.37132984920301e-18	0.0040369901262935
+CT>TA	0.00787574920123564	0.00340930028170849	0.000183448785239448	7.00403091014318e-18	0.00333965163488195	8.84808908239154e-05	9.036966293971e-18	0.0108954317048159	9.03108699441082e-18	0.00400896886535602	0.0418762408622981
+CT>TC	0.0105883952129288	3.87328789401202e-05	0.00632100705662012	7.00403091014318e-18	0.000236975280678749	8.30759495292418e-18	0.063178790904753	0.0177925398482315	3.00368747042488e-05	0.0027356487294613	0.00300263693473073
+CT>TG	0.00225885764542482	0.000393380801735595	0.0520436227690173	3.081773600463e-05	0.00087390884098408	0.0112102486111748	9.036966293971e-18	0.000965595140078182	9.47162782340647e-18	0.0454615079768661	0.00148625507137173
+GC>AA	0.00158449926475142	0.00509572963466284	2.14163215845169e-05	0.326375814639811	0.000132251453064467	8.26170007893507e-18	8.98704204614045e-18	0.012823357977946	8.98119522646331e-18	0.00403628581338043	0.000998678603332873
+GC>AG	0.000107304697043293	0.000326006325052249	0.000517561104959159	0.0112440448336277	0.00264502906128933	0.00364311111914487	7.25723528062227e-05	0.00846938061799223	0.123466541915903	7.33060732283065e-18	0.00328565260496515
+GC>AT	4.88386798692369e-05	0.00095595085469167	0.00395607051491771	0.00919424550997517	0.00156116376925724	0.00187132483715638	0.000347949636742163	0.00547726375647148	0.125457937753257	0.00766696447394568	0.0271640580106541
+GC>CA	5.77640238289127e-05	0.00106328216786272	0.000234984639607895	0.0118410737628468	0.0045542229701899	0.00864990044408985	0.000666075018906428	0.00480130380104488	0.02728212297174	0.000103875002550232	0.00210721185303236
+GC>CG	5.16466532498091e-06	6.71071481415245e-05	1.10056097031545e-17	9.78132395704069e-07	0.000321182100299419	8.99828538717747e-18	0.00263447582104781	0.000240562219431234	0.0024892447966916	7.33060732283065e-18	0.00403466155746481
+GC>TA	8.29354994904702e-07	0.000738278939195246	0.00419402964363457	0.0176123534119654	0.000220750545716628	0.000825174622341827	6.20344495220314e-06	0.00850914296831143	0.013939770861473	0.00277989292539192	0.000242678900609888
+TA>AT	0.000504971228544323	0.00275052540183135	0.00143350572498961	0.0301618523646949	0.00185408960514584	0.00850574690040247	0.0553124433348494	0.00961444216508748	0.0153886172750149	0.010258772260155	0.00222060293444846
+TA>CG	7.54956985249432e-06	1.89036109434954e-05	0.00330200629066574	0.00038595265032455	7.82287004524101e-06	0.000257058161867473	0.00302335039733496	2.07156537371472e-05	0.00134029892395291	0.0040541878835805	0.000581539064447487
+TA>CT	0.00070196000482795	0.000280053495459192	0.000340086875445813	0.00865168923092566	0.00225068631212891	0.0259043166978418	0.0288457365778515	0.00406383637905759	0.0140979590519492	0.00159800106360107	0.00336575691409676
+TA>GC	2.00988548390908e-05	8.22157047383769e-05	0.00196736302946851	6.96500669737364e-05	5.17558702612903e-05	0.000262020674644837	0.00149680626228714	0.000782040708067425	0.000574839316273137	7.30937523536046e-18	0.00101570179064458
+TA>GG	7.0295994785477e-05	7.89150742561793e-05	0.00539789052306435	0.0022026089555797	0.001616131580956	0.000216365557093086	0.00427234105328317	0.000215085974208658	0.00322664555766442	0.00847335131872421	0.000373419775972273
+TA>GT	0.00114993448084351	0.00130024837177482	0.000357882118928442	0.00799685954142899	0.00189374927584415	6.20314097170542e-05	0.0260702017868555	0.000151650479511174	0.00772409305803973	0.00356097767876535	0.00265874880492259
+TC>AA	1.10480988298362e-05	0.00147006576888118	0.00550160708190254	0.38116185568263	0.0406028271297742	0.0460768634513965	0.0196938448407757	0.0389825171904766	0.00371347122518981	0.00755909218025223	0.000219034021332678
+TC>AG	3.13198398020127e-06	0.000202767692259473	6.15298132657224e-06	0.00188066667579557	0.014974805055288	0.00833005304317821	4.01915200832158e-06	0.0116545669950909	0.0469970477551121	0.000270967457784173	0.0478442977473225
+TC>AT	0.00249342413957771	4.22770638361003e-18	0.00112236792927702	0.00845797152055652	0.000751755314184929	0.00059759076179322	0.0023009645247641	0.0185870249490674	0.0521294876598461	0.00308962894669039	0.0853929871186388
+TC>CA	4.48005475485101e-06	0.000691437830604804	0.0656384815782543	0.0850825672579169	0.00143717927711825	0.0118713316315825	0.00272297548563787	0.0176827913028965	0.0491104053629437	0.0251969739341741	0.000284643290395463
+TC>CG	3.34483726040912e-05	3.94383161444676e-06	0.000116245249817977	0.000402281641881404	1.06532170191982e-17	0.000867210836137635	0.00163780444339104	0.0109512741591803	0.00783955036428959	0.000841898890975182	0.00327036971943723
+TC>CT	0.00192581539235676	0.00339635884534619	0.0194410159178341	8.32722998694506e-06	0.00105527149718473	0.00944676305258979	0.00923400173911883	0.00880120748939626	0.0517269433535924	0.0261968538521969	0.0202884047409532
+TC>GA	6.50722885206865e-05	0.000897247038248169	0.0779644865158502	0.0366076294112077	2.47235036483279e-05	0.00738437069286571	9.08328353880676e-18	0.00965520593300206	0.0174100412454698	0.0437947404093979	0.000237202741996219
+TC>GG	0.000416584276978227	1.0006585613005e-05	0.000177374217394672	1.04593226889165e-05	3.49747124781224e-05	0.00151912803082115	0.000709380329468758	0.0019189847379848	0.00375372565581517	7.40911019254881e-18	0.00739870680354163
+TC>GT	0.005169293947905	8.68859561331843e-05	0.0434917572594845	7.03992873292456e-18	3.87937902774576e-05	8.35017394424869e-18	9.08328353880676e-18	0.000277298318159059	9.20820100555195e-18	0.0458944882372457	0.0153424752269895
+TG>AA	0.00138117400432027	0.00298488256850051	6.65825562048864e-05	0.00763240727083881	0.0179934395849107	0.0255166928805809	0.0225865373304628	0.00864412496921782	0.0158153045638171	0.00141222197884899	0.0078610467814133
+TG>AC	0.000238933021185331	0.000221849380091253	8.01382862106716e-05	0.000118037229090299	0.00145946787744276	0.0101066116899556	0.00261843928344303	0.00384738510190619	0.00727704203664244	0.000205866161705451	0.000869433781954523
+TG>AT	0.00242965646015462	0.00432606291177945	0.000954881569525168	7.0022085053567e-18	0.0203925648628988	0.221144671631701	0.00128923155558836	0.00821441702277115	0.000746722607886556	0.00248630630079047	0.0105416336149221
+TG>CA	0.000281275581901718	0.000145210503332457	0.0158482431685283	0.000804253662615256	0.000475826513467639	0.0114074626995538	0.0238857629291177	0.00505656327679099	0.0228220850667741	0.0290400575932327	0.0563224424568693
+TG>CC	0.000103840089375903	5.98993326246385e-05	0.000482424509029416	0.000120037860091829	0.000505815579442491	0.00789516497363855	0.00104937452199053	0.0012491510071124	0.0118114299906989	0.000188959278860076	0.00314241078235295
+TG>CT	0.00186508898393613	0.00309580725854613	0.00605024125993504	8.21259026128265e-05	0.000327880454658373	0.275180021261167	9.03461493218511e-18	0.0194867557109534	0.00096893764669462	0.00430628251296909	0.00560212529250143
+TG>GA	0.000410319576465947	0.00148235722151883	0.000521297558310713	0.00785247668100716	0.00326880819125878	0.007444870393393	0.00824508552992558	0.000270815938341968	0.00618598621546771	2.0089354910387e-05	0.00733898492619811
+TG>GC	8.96250868496873e-05	0.00027428650629464	0.000496378936976548	0.000604190562462208	0.000291893575488552	0.0056036658875001	0.00387768870983166	0.00353759565214232	0.0039137873952231	7.36941187554295e-18	0.00614426644984027
+TG>GT	0.00191549679431277	0.0064538001481092	0.0102664719896756	3.23101906747174e-05	0.0826698585373399	0.0274179366638398	0.0087048115109881	0.00785466153272277	0.00334323526855375	0.00215811386908613	0.00526077715639919
+TT>AA	0.00554720337294364	0.00435598849704567	0.00321672392307967	1.80461024721005e-05	0.00492924838783148	0.000193559918436418	0.235387282038808	0.00358560026647744	0.000342096607337598	0.0144529513067107	0.00479966485598206
+TT>AC	0.000727502081697526	0.00034868121380064	0.00242752768108185	6.61690423977018e-07	0.000967815842001059	0.000128371344869748	0.0400659203470312	1.13176768187696e-17	0.00668141760958476	7.38595649536045e-18	0.00104646780927072
+TT>AG	0.00042235537520773	0.000217294089759819	0.0228767011920882	7.01792873915019e-18	0.000894678619986486	0.00212615039940521	0.0539888276676245	0.0146228390755784	0.000920952156996819	0.00693741662722115	0.00127789819016713
+TT>CA	0.000732554179487092	4.21449467115556e-18	0.0006932939138563	7.01792873915019e-18	1.0519737413055e-17	8.32407939389773e-18	0.0978610104476238	0.00629983957434166	9.05903919137394e-18	0.00128581428866599	0.0020325624756989
+TT>CC	0.00547647400388971	3.01179715108958e-06	0.00815169789202796	7.01792873915019e-18	0.000774453049551572	8.32407939389773e-18	0.0354583395071226	0.000294459910152057	0.00517659382364225	0.00287065515609151	0.00402487618950277
+TT>CG	8.46731589531287e-05	1.53621868109267e-05	0.0317676461968737	7.2685690512627e-18	1.0519737413055e-17	1.1232492676103e-05	0.00267440018316433	0.000116181461148431	1.98636739744412e-05	0.00855216015252263	1.00219417118619e-17
+TT>GA	0.0018793803777186	4.84111018581178e-05	0.0122874857931304	7.01792873915019e-18	2.99562046333661e-05	8.32407939389773e-18	0.043671853178264	0.00363567848248969	9.19948941139524e-18	0.00866180323140112	0.000711396866494616
+TT>GC	0.00107104473138802	1.55643208479127e-06	0.0664323418896887	7.01792873915019e-18	5.67063940551345e-05	4.10186562904117e-07	0.00367604819184011	0.000286447395590098	3.57144845197024e-05	0.0257162857733198	5.81594609383151e-06
+TT>GG	0.0016267754882403	4.21449467115556e-18	0.170826022002057	7.01792873915019e-18	1.0519737413055e-17	8.32407939389773e-18	9.05489799842905e-18	0.000538841604291861	9.04900703280099e-18	0.0844251707364413	7.38564780773759e-18
diff --git a/SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_ID83_Signatures.txt b/SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_ID83_Signatures.txt
new file mode 100644
index 0000000..0ea3c62
--- /dev/null
+++ b/SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_ID83_Signatures.txt
@@ -0,0 +1,84 @@
+MutationType	ID1	ID2	ID3	ID4	ID5	ID6	ID7	ID8	ID9	ID10	ID11	ID12	ID13	ID14	ID15	ID16	ID17	ID18
+1:Del:C:0	0.000159889000761019	0.0048241160289447	0.124727109374181	0.00724971696375141	0.0222021078667874	0.0305067990915204	0.000466560997200634	0.0398275578805173	0.33493987999518	0.0251054140979111	0.00157656499873875	0.052787740788849	0.0655483705411614	0.0120160090841121	0.026527369337078	0.000952768885842137	0.00611759853519847	0.00601204810230084
+1:Del:C:1	0.000773523003681714	2.21000001326e-05	0.208876169626629	0.00273486898632566	0.0285472148287167	0.00549190301647571	1e-18	0.0239159379282522	0.0999942257000173	0.0293063201142946	0.000550317999559745	0.0146746649413013	0.0175364628772448	0.00194623201362362	0.12100978700592	2.63915642267698e-18	0.00366755530652	0.00200401603410028
+1:Del:C:2	3.31000001575451e-18	3.11000001866e-06	0.176324217528973	0.00204106298979469	0.0265969268404184	0.00803399402410198	0.00856194494862833	0.00333055399000834	0.00269065499192804	0.0188040560733358	0.00035733799971413	0.000561931997752272	0.00512021896415847	0.000683696004785872	0.147828864433683	8.1541662061712e-05	0.00122032669693285	0.00200401603410028
+1:Del:C:3	0.00190761300907961	0.00247207601483246	0.0640427641921283	0.00111228299443858	0.0141591219150453	0.00110237900330714	0.0423601467458391	0.00540315298379054	0.0106254159681238	0.0165035600643639	9.07999999273599e-18	0.000995576996017692	0.00535051596254639	0.000487468003412276	0.136006057901119	0.00162491353986988	2.25926833737838e-08	0.00400803206820056
+1:Del:C:4	0.000705990003360279	0.00385697602314186	0.0439898081319694	0.00107568399462158	0.00287342198275947	0.00247817000743451	0.114891908310649	0.00127570899617287	0.0124969019625093	0.00293063201142946	9.07999999273599e-18	0.0022400499910398	0.00434600496957797	0.00207192101450345	0.0841976961066638	0.00337864255670055	1.94094358196916e-08	1e-18
+1:Del:C:5	0.00337011501604064	0.0146154240876925	0.0224174860672525	0.00224617798876911	0.00260244898438531	0.00132207300396622	0.251763140489421	0.000933728997198813	4.47999998656e-05	8.420000032838e-18	0.000156464999874828	0.0294108078823568	0.000843055994098608	0.00237027601659193	0.0184582927326813	2.65063753759673e-18	0.00122093334450846	0.00200401603410028
+1:Del:T:0	0.00131160500624281	0.0079059660474358	0.0375992301127977	0.00663505196682473	0.101481148391113	0.00428416201285249	0.00266748998399506	0.0342436868972689	0.105105372684684	0.0283061051103938	0.000944205999244634	0.0451351178194595	0.0536987616241087	0.0183098031281686	0.0239516368486624	0.000628649514543184	0.0060883465666712	0.0861726904663161
+1:Del:T:1	3.31000001575451e-18	3.9500000237e-18	0.0133098240399295	0.00162246599188767	0.106099610363402	0.000677688002033064	0.00773272495360365	0.0104520759686438	0.0442936408671191	8.420000032838e-18	0.000258504999793196	1.41999999432e-17	0.498224164512431	0.000852559005967913	0.0799601100183372	0.000157040098524865	0.00490319649725692	0.172345379932628
+1:Del:T:2	0.000936453004457207	0.00703641804221851	0.0165018510495056	0.00263340498683298	0.114128463315229	0.011659665034979	0.00025475999847144	0.00899202997302391	0.0858619557424141	0.00151032600589027	0.000516518999586785	0.0109692039561232	0.0237778048335554	0.010856423075995	0.120410466467629	2.65806380183744e-18	0.00122548208393169	0.118236947011921
+1:Del:T:3	0.00229585501092751	0.0202347431214085	0.0201414770604244	0.00030603799846981	0.0889622074662269	0.0222423910667272	0.0289727418261635	0.00982504497052486	0.113250662660248	0.00142030600553919	0.000425679999659456	0.0221093659115625	0.0627809515605333	0.0171839501202877	0.113431215342833	2.6607938700793e-18	0.00122381019049612	0.238477910057941
+1:Del:T:4	0.00429142202042575	0.0471199252827195	0.0158143640474431	0.00102320199488399	0.0522595316864428	0.0176971410530914	0.158850552046897	0.00127377999617866	0.0944127367167618	0.00241052000940103	0.00193245099845404	0.0440779638236881	0.0230043818389693	0.0133479030934353	0.079178831808195	0.00100165069513296	1.34150268406511e-09	0.0901807225345166
+1:Del:T:5	3.31000001575451e-18	0.814697226888183	0.00806631402419893	0.00015444199922779	0.0306105228163369	0.00795434502386303	1.91999998848e-07	0.010620341968139	0.000929834997210495	1.270000004953e-17	0.00653939499476847	0.000348511998605952	0.00607957495744298	0.038616999270319	0.046903214753917	2.79097673434101e-18	4.62677534678498e-08	0.0701405621935138
+1:Ins:C:0	3.31000001575451e-18	3.9500000237e-18	0.00208309200624928	6.61999996689999e-18	0.000542251996746488	0.00208688700626066	0.000672366995965798	0.00276427099170719	5.40999998377e-18	8.420000032838e-18	0.00018623799985101	1.41999999432e-17	0.002850427980047	0.454386958180709	6.58004610552164e-18	0.0602713372040219	0.00487811801329939	1e-18
+1:Ins:C:1	3.31000001575451e-18	0.000227026001362156	0.00157888700473666	0.000272398998638005	0.00124289799254261	0.0017734330053203	2.61999998428e-05	0.00216911899349264	1.92999999421e-06	0.000345074001345789	0.163482883869214	0.000167696999329212	0.00165225598843421	0.012777431089442	6.58004610552164e-18	0.136484095403874	0.0147671987268637	0.00200401603410028
+1:Ins:C:2	3.31000001575451e-18	2.62000001572e-05	0.00174794600524384	6.87999996559999e-05	0.00315166698109	0.000246169000738507	2.57999998452e-05	0.001526999995419	0.000352622998942131	0.00027205900106103	0.0937388429250088	0.00159658599361366	0.00082124999425125	0.00065885000461195	6.58004610552164e-18	0.124683558062386	0.0292604047473039	1e-18
+1:Ins:C:3	0.000845986004026614	0.0004300500025803	0.00617764701853294	0.000512480997437595	0.000602847996382912	0.000232169000696507	0.00240773498555359	0.000116523999650428	5.40999998377e-18	0.00258055601006417	0.0361756399710595	0.000450318998198724	0.000375554997371115	0.00156440301095082	6.58004610552164e-18	0.0988831205554055	0.0492545218208812	1e-18
+1:Ins:C:4	0.00178552500849851	0.00291184601747108	0.00710444702131334	6.61999996689999e-18	0.000197581998814508	0.000376592001129776	0.0154854309070874	0.000554176998337469	2.15999999352e-06	0.000411089001603247	0.0111897889910482	0.00439392998242428	0.000148577998959954	0.00153950201077651	6.58004610552164e-18	0.0620943792528956	0.024538407850484	1e-18
+1:Ins:C:5	0.0242965361156435	0.00901753605410521	0.00735110102205329	0.000249142998754285	0.000433543997398736	0.000247997000743991	0.0603432286379406	0.000489488998531533	7.36999997789e-05	0.000851184003319617	0.00341224199727021	0.017051489931794	0.000706980995051133	0.00229299901605099	6.58004610552164e-18	0.0310346026384888	0.00979050282269531	1e-18
+1:Ins:T:0	0.00228382401087025	0.00132855600797134	0.0187223650561671	0.000333664998331675	0.00636196496182821	0.00639625101918875	1.35999999184e-06	0.00450797898647606	0.0126144839621565	0.0170036670663143	0.000406944999674444	0.0042653009829388	0.0411370127120409	0.032612007228284	6.58004610552164e-18	0.0301942868072769	0.00489279435946823	1e-18
+1:Ins:T:1	4.03000001918147e-05	3.9500000237e-18	0.0431190291293571	0.00101004399494978	0.0134626969192238	0.00104118700312356	0.000373647997758112	0.00486869598539391	0.0103852739688442	0.0438094491708568	0.314277275748578	0.00249651799001393	0.00474885296675803	0.00316588302216118	6.58004610552164e-18	0.103160227092233	0.0388936407223243	0.00200401603410028
+1:Ins:T:2	0.000192865000917974	0.000647033003882198	0.0401570401204711	1.0599999947e-05	0.0297211438216731	0.000738848002216544	0.0183827058897038	0.00142963599571109	0.00231466299305601	0.00365078701423807	0.161807822870554	1.41999999432e-17	0.0030541709786208	0.00177460601242224	6.58004610552164e-18	0.108738482879835	0.0439246079078755	1e-18
+1:Ins:T:3	0.00424326702019655	0.00108287900649727	0.0251254340753763	0.000173934999130325	0.0188402498869585	0.000930638002791914	0.00889163494665019	0.00108728599673814	0.00160088499519735	0.00375080901462815	0.10772532691382	0.000105673999577304	0.009271856935097	0.00117383600821685	6.58004610552164e-18	0.100939445323406	0.00487209062147903	0.00200000801803214
+1:Ins:T:4	0.0166491270792444	0.00348746102092477	0.00656330501968992	1.599999992e-05	0.0112687519323875	0.00134985200404956	0.0127879689232722	0.000822617997532146	0.00158535499524393	9.660000037674e-06	0.0490306799607755	0.00033647999865408	0.0120986409153095	0.00478499903349499	6.58004610552164e-18	0.0519623764470054	0.00490348556483425	0.00801606413640112
+1:Ins:T:5	0.890906468240421	0.00313258501879551	0.0261812390785437	0.000832925995835369	0.00143921499136471	0.0143900410431701	0.0107898489352609	0.0201612479395163	0.00577247998268256	1.110000004329e-08	0.0236290429810968	0.0001665499993338	0.0110997939223014	0.232747554629233	6.58004610552164e-18	0.0350076858492558	0.00487382956865314	0.00400803206820056
+2:Del:R:0	0.000686046003265353	0.000163809000982854	0.00689755302069266	0.0717242136413788	0.0280544068316736	0.00178364700535094	2.32999998602e-05	0.00876921897369234	0.0131747469604758	0.000839181003272806	9.07999999273599e-18	0.00626810497492758	0.0221843988447092	0.000661996004633972	6.58004610552164e-18	0.00192294222546196	0.0146820538320339	1e-18
+2:Del:R:1	0.00121996900580665	0.00356888502141331	0.00847465402542395	0.230512878847436	0.0245627288526236	0.00245434700736304	0.00818230195090619	0.0103071449690786	0.00319854099040438	0.00947204203694096	0.00136309899890952	0.0002784249988863	0.00433321496966749	0.00660003604620025	6.58004610552164e-18	0.00201464612586734	0.00853595089340418	0.036072288613805
+2:Del:R:2	0.000472749002250129	0.00184957401109744	0.0118006410354019	0.055059395724703	0.00456261797262429	0.0020886000062658	0.00899154094605075	0.000532025998403922	0.00118969699643091	0.0065414110255115	0.000150728999879417	0.00139816699440733	0.00310892397823753	0.00270193001891351	6.58004610552164e-18	0.001116794298881	1.46002268078368e-08	0.00200401603410028
+2:Del:R:3	0.000426720002031046	0.000739044004434264	0.00667112502001338	0.012811005935945	0.000395918997624486	0.000525746001577238	0.0721321375672072	2.70999999187e-05	9.58999997123e-05	0.000185040000721656	9.07999999273599e-18	0.00067330999730676	0.000105565999261038	0.000392799002749593	6.58004610552164e-18	0.000472257144989337	3.49583154490229e-08	1e-18
+2:Del:R:4	5.4600000259878e-05	0.000881932005291592	0.00282252500846758	0.00321921798390391	0.000867562994794623	0.000232527000697581	0.0522508416864949	0.000274026999177919	5.40999998377e-18	8.420000032838e-18	9.12999999269599e-06	0.011980738952077	6.12999995709e-06	1.41000000987e-06	6.58004610552164e-18	3.88261199448798e-05	4.34453853127852e-08	0.00200401603410028
+2:Del:R:5	3.31000001575451e-18	4.67000002802e-18	0.000101239000303717	0.0023827209880864	0.0214267798714393	0.000215685000647055	0.057046330657722	0.000833078997500763	5.40999998377e-18	8.420000032838e-18	0.00452771299637783	0.251519843993921	6.62999995359e-05	4.37000003059e-05	6.58004610552164e-18	2.64064568478846e-18	3.88695242109537e-08	1e-18
+3:Del:R:0	0.000128045000609452	1.2500000075e-05	0.000589124001767372	0.00506895397465523	0.0171363698971818	0.00105104700315314	0.000625411996247528	0.0109641009671077	0.00285809499142572	0.00120025900468101	0.000189441999848446	0.00759985896960056	0.00303966697872233	0.00114665900802661	6.58004610552164e-18	0.00106014137936679	0.00855857290020103	0.00400803206820056
+3:Del:R:1	0.00501108502385111	0.00500325803001955	0.000372386001117158	0.0971144655144276	0.00590979396454124	0.00541365301624096	0.011689002929866	0.0013488669959534	0.00430190998709427	0.0427092111665659	0.00039086299968731	0.000569428997722284	0.00118696299169126	0.00484016503388116	6.58004610552164e-18	0.00232592325104706	0.00244544588016729	0.00601204810230084
+3:Del:R:2	0.000769383003662009	0.00228989101373935	9.63000002888999e-05	0.0214842818925786	0.000842709994943741	0.000536054001608162	0.00547484896715091	0.000376570998870287	0.00127571699617285	0.00506109101973825	0.000170421999863662	0.00268033898927864	0.000384378997309347	0.00105348100737437	9.35232649418987e-05	0.00115037509281033	3.41157810969492e-08	1e-18
+3:Del:R:3	0.000371256001767056	0.000402587002415522	2.45000000735e-05	0.00383762698081187	0.00062115499627307	4.7000000141e-05	0.00345674797925951	0.000253508999239473	0.00030210999909367	0.0027305890106493	0.000127575999897939	0.0059200509763198	6.8999999517e-05	0.000249605001747235	6.58004610552164e-18	0.000120553148361788	1.98537113438362e-08	1e-18
+3:Del:R:4	3.31000001575451e-18	3.97000002382e-18	3.82000001146e-06	0.000786294996068524	0.00586707496479755	7.31000002193e-05	0.000492536997044778	2.67999999196e-06	5.40999998377e-18	8.420000032838e-18	0.00120210799903831	0.0686221427255114	3.08999997837e-06	9.19000006432999e-18	6.58004610552164e-18	1.60702399271993e-05	2.13065194170608e-08	1e-18
+3:Del:R:5	3.31000001575451e-18	3.9500000237e-18	3.83000001149e-07	0.00113860899430696	0.00837891094972654	0.000150616000451848	0.000436588997380466	9.0999999727e-05	5.40999998377e-18	8.420000032838e-18	0.00174236299860611	0.0974809436100762	9.95999993028e-05	9.19000006432999e-18	6.58004610552164e-18	9.5808476364924e-06	4.51480725749292e-08	1e-18
+4:Del:R:0	9.97000004745391e-05	1.21000000726e-05	0.000177645000532935	0.00725242896373785	0.0107912649352524	0.00231509800694529	0.000130876999214738	0.00669130897992607	0.00143277399570168	0.00147031700573424	9.07999999273599e-18	0.00173451599306194	0.00215534898491256	0.000193687001355809	6.58004610552164e-18	0.000698912463470956	0.00610958539657406	0.00400803206820056
+4:Del:R:1	0.000900503004286097	0.00211578701269472	0.000634573001903719	0.0635237296823813	0.00284356898293859	0.00280672900842019	0.00339680397961918	0.00162295499513113	0.00459421698621735	0.000521112002032337	0.000355503999715597	0.00230259499078962	2.2999999839e-05	0.000617337004321359	6.58004610552164e-18	0.00042629598802982	1.55350861485771e-08	0.00200401603410028
+4:Del:R:2	3.23000001537373e-06	0.000543292003259752	0.000116799000350397	0.0145489219272554	0.000164643999012136	0.00047449000142347	0.00277738698333568	0.000272622999182131	0.000896023997311928	7.50000002925e-05	9.07999999273599e-18	0.000611678997553284	7.91999994456e-05	0.000524295003670065	6.58004610552164e-18	7.83497537232868e-05	3.82649435383251e-08	1e-18
+4:Del:R:3	3.31000001575451e-18	7.27000004362e-06	4.12000001236e-18	0.00455475197722624	0.00387781397673312	0.000291345000874035	0.000439585997362484	2.87999999136e-05	2.37999999286e-05	0.000132028000514909	0.00031213699975029	0.0392590578429638	3.91999997256e-05	5.03000003521e-05	1.39447221625922e-06	2.63651088832343e-18	1.46064127217749e-08	1e-18
+4:Del:R:4	3.31000001575451e-18	3.9500000237e-18	4.12000001236e-18	0.000849678995751604	0.00455725397265648	0.000110576000331728	0.00020180999878914	9.72999997081e-05	5.40999998377e-18	8.420000032838e-18	0.000687365999450106	0.0532878727868485	9.46999993371e-06	7.73000005411e-06	6.58004610552164e-18	2.6309868244796e-06	3.1937229480471e-09	1e-18
+4:Del:R:5	2.89000001375545e-05	0.000210413001262478	2.83000000849e-06	0.000610779996946099	0.00158443599049338	5.68000001704e-05	0.000250763998495416	6.33999998098e-06	1.36999999589e-05	0.000209045000815275	0.000157602999873918	0.0186444489254222	6.2999999559e-05	9.19000006432999e-18	1.7594366617604e-06	2.63797428510975e-18	4.43808926111075e-09	1e-18
+5:Del:R:0	8.35000003974324e-06	3.8500000231e-05	0.00177678500533035	0.00413282597933587	0.0184479488893123	0.0193332910579999	8.5499999487e-05	0.237978862286063	0.000772051997683844	0.00139030000542217	0.00128145399897484	0.00338288498646846	0.0200975358593172	0.0060868140426077	0.000284018024499145	0.00556879013589966	0.0233963755718201	0.0240481924092034
+5:Del:R:1	0.000190676000907555	0.00297751201786507	7.41000002222999e-05	0.0157185329214073	0.00041033499753799	0.00750182502250548	0.00347672897913963	0.000572256998283229	0.000479550998561347	0.026205652102202	0.000474633999620293	0.00279703498881186	0.00298053397913626	0.000314462002201234	6.58004610552164e-18	0.000110240786487051	1.91584159796717e-08	1e-18
+5:Del:R:2	0.000126355000601408	0.00039752500238515	2.78000000834e-06	0.00234384498828078	0.00047092499717445	0.000370524001111572	0.0011688999929866	0.000516837998449486	0.000264968999205093	0.00177038200690449	9.07999999273599e-18	0.00510384197958463	6.98999995107e-05	2.13000001491e-05	6.58004610552164e-18	1.54338573933316e-05	4.85820225219303e-08	1e-18
+5:Del:R:3	1.89000000899578e-05	0.000158151000948906	4.12000001236e-18	0.0011824799940876	0.000257166998456998	0.000168175000504525	0.000406616997560298	8.15999997552e-06	6.11999998164e-06	0.000137030000534417	9.07999999273599e-18	0.00220095199119619	6.3999999552e-06	2.85000001995e-05	1.2457865811275e-06	6.72531113763592e-06	3.43435927859616e-08	1e-18
+5:Del:R:4	3.11000001480257e-06	8.47000005082e-05	4.37000001311e-05	0.000146922999265385	9.72999994162001e-05	5.32000001596e-05	0.000125881999244708	0.000112897999661306	7.24999997825e-06	0.000125027000487605	9.07999999273599e-18	0.00125618599497526	1.45999998978e-06	1.5000000105e-05	6.58004610552164e-18	2.67193468891148e-07	9.20661205435291e-09	1e-18
+5:Del:R:5	3.13000001489777e-05	2.12000001272e-05	3.82000001146e-06	0.00010617399946913	0.000585017996489892	1.15000000345e-05	2.07999998752e-05	4.42999998671e-05	2.98999999103e-05	0.00112024200436894	8.17999999345599e-08	0.00618125997527496	2.34999998355e-06	9.08000006356e-05	1.73649230813665e-06	2.62957009910824e-18	3.33535657530527e-08	1e-18
+2:Ins:R:0	0.000402036001913559	0.000331853001991118	0.00263595000790785	0.00049292199753539	0.00634945396190328	0.00199838700599516	3.03999998176e-05	0.00191670999424987	0.00116233899651298	0.0253054580986913	0.000190466999847626	0.00744033097023868	0.0106184109256711	0.0239422561675958	6.58004610552164e-18	0.0021917928286492	0.0343794135783801	1e-18
+2:Ins:R:1	7.8800000375062e-06	0.00027166500162999	0.00224268300672805	0.000553301997233489	0.0183876418896741	0.000208533000625599	0.000397625997614244	0.00166181599501455	0.00210019199369942	0.0389083921517427	9.07999999273599e-18	0.0010623009957508	0.00180136798739042	0.000123773000866411	6.58004610552164e-18	0.00108784776586042	0.0585086492632652	1e-18
+2:Ins:R:2	0.000221347001053539	0.00103534100621205	0.000955604002866811	0.000266334998668325	0.0072079519567523	0.000790414002371242	7.00999995794e-05	0.000304585999086242	0.000760940997717177	0.026205652102202	0.000247884999801692	0.000550237997799048	0.000688523995180332	0.00111419900779939	6.58004610552164e-18	0.000729931569198568	0.0636941929664411	1e-18
+2:Ins:R:3	0.000514268002447746	0.000381326002287956	0.000897238002691713	0.00013779399931103	0.00117229199296625	0.000499074001497222	0.00314703898111777	0.000177582999467251	0.000351634998945095	0.000280060001092234	0.000372355999702115	0.0001655249993379	0.000743543994795192	0.000871483006100381	6.58004610552164e-18	9.48112433024279e-05	0.00976271301510184	0.00200401603410028
+2:Ins:R:4	0.00291310001386539	0.00197742301186454	0.000253085000759255	7.18999996404999e-05	6.87999995872e-05	0.000189469000568407	0.00182827998903032	1.65999999502e-05	3.06999999079e-05	8.420000032838e-18	0.000442383999646093	0.00101820599592718	0.000213353998506522	0.00297397802081785	6.58004610552164e-18	0.000131664280470189	3.84371444624452e-09	1e-18
+2:Ins:R:5	0.0181215840862528	0.0136333760818003	6.67000002001e-06	0.000103688999481555	0.000994121994035269	0.000748642002245926	0.00024476999853138	0.00176438399470685	5.40999998377e-18	8.420000032838e-18	0.000288800999768959	0.0380051968479792	0.000846574994073975	0.000544275003809925	6.58004610552164e-18	1.18323308639907e-06	4.64406625218008e-08	0.00200401603410028
+3:Ins:R:0	3.06000001456459e-07	5.78000003468e-05	9.60000002879999e-05	2.62999998685e-05	0.00379247797724513	0.00121918500365755	1e-18	0.000667862997996411	0.000254572999236281	0.0181039050706052	9.07999999273599e-18	0.0151501399393994	8.20999994253e-05	0.00662349704636448	6.58004610552164e-18	0.000570589182021802	0.0195831374457896	0.00400803206820056
+3:Ins:R:1	0.000254695001212264	0.0012270500073623	0.000286144000858432	0.000450982997745085	0.00612276096326343	0.000288615000865845	5.50999996694e-06	0.000671722997984831	0.000823354997529935	0.0552119082153264	0.000207082999834334	0.000869572996521708	0.0036883279741817	0.0025232000176624	6.58004610552164e-18	0.001092184115997	0.112273274400416	1e-18
+3:Ins:R:2	4.41000002099014e-05	0.00021007500126045	9.75000002924999e-05	0.000600334996998325	0.00114346799313919	0.000746533002239599	5.46999996718e-05	0.000135767999592696	0.000118260999645217	0.00943203403678493	0.000221525999822779	0.000183890999264436	0.000202510998582423	0.000204501001431507	6.58004610552164e-18	0.000281270540937246	0.0388744786920139	1e-18
+3:Ins:R:3	0.000166702000793446	3.02000001812e-06	1.36000000408e-05	7.41999996289999e-05	1.01999999388e-05	0.000249737000749211	0.000177832998933002	3.78999998863e-05	5.17999998446e-06	0.000461099001798286	2.179999998256e-05	8.6999999652e-05	2.36999998341e-05	0.000327493002292451	6.58004610552164e-18	3.18038761003157e-05	1.39169498026687e-08	1e-18
+3:Ins:R:4	8.89000004231347e-05	0.000141807000850842	1.56000000468e-06	7.39999996299999e-05	1.17999999292e-05	0.000155952000467856	0.000415608997506346	0.000122040999633877	1.60999999517e-05	0.000187040000729456	9.07999999273599e-18	0.000340787998636848	3.48999997557e-06	0.00060186000421302	6.58004610552164e-18	7.5573360370254e-05	2.83510026533301e-08	1e-18
+3:Ins:R:5	0.00124869600594338	0.00186470701118824	4.12000001236e-18	3.9599999802e-05	0.000102573999384556	1.98000000594e-05	0.000769275995384344	3.65999998902e-05	5.40999998377e-18	0.000185040000721656	9.00999999279199e-05	0.00284031198863875	3.53999997522e-05	0.00220599701544198	6.58004610552164e-18	2.28987512369934e-05	2.78074941910782e-08	1e-18
+4:Ins:R:0	3.31000001575451e-18	1.68000001008e-05	4.12000001236e-18	0.000166644999166775	0.00243918598536488	0.00146791700440375	1e-18	0.000777757997666726	0.000164386999506839	0.0160034520624135	0.000159620999872303	0.00570117797719529	0.00111879699216842	0.00594693004162851	6.58004610552164e-18	0.000327559887237071	0.0146924521955361	1e-18
+4:Ins:R:1	0.000744381003543008	0.00120372800722237	0.000175982000527946	0.00126643499366782	0.00361229797832621	0.000476283001428849	2.60999998434e-05	0.0011039009966883	0.000715564997853305	0.0746160922910027	0.000377635999697891	0.00190888599236446	0.00269163498115856	0.00132692600928848	6.58004610552164e-18	0.00150697819353949	0.210245111019824	0.00200401603410028
+4:Ins:R:2	7.55000003593551e-05	1.22000000732e-05	2.74000000822e-05	9.83999995079999e-05	0.000376458997741246	0.000528663001585989	0.000194816998831098	7.98999997603e-05	4.23999998728e-05	0.00409088201595444	9.07999999273599e-18	0.00021848999912604	6.92999995149e-05	8.45000005915e-05	6.58004610552164e-18	4.49962737763675e-05	0.00974909693497787	1e-18
+4:Ins:R:3	0.000157544000749857	0.000134169000805014	4.77000001431e-05	5.24999997375e-05	1.86999998878e-06	0.000334824001004472	0.000273741998357548	8.57999997426e-06	2.14999999355e-05	0.000239052000932303	9.07999999273599e-18	0.000176568999293724	6.38999995527e-07	0.000713852004996964	1.36092421699612e-06	3.01646709616391e-07	1.86094344198747e-08	1e-18
+4:Ins:R:4	0.000319653001521443	0.00024938500149631	4.18000001254e-06	0.000146910999265445	6.40999996154e-06	5.6000000168e-05	0.000258756998447458	0.000205514999383455	5.40999998377e-18	0.00228049200889392	9.07999999273599e-18	0.000636052997455788	1.20999999153e-05	0.00166501001165507	1.44599935194735e-06	9.39515537716102e-06	9.67765006760512e-09	1e-18
+4:Ins:R:5	0.00100132000476595	0.00219354501316127	3.29000000987e-05	0.000135204999323975	0.000635976996184138	0.000106861000320583	8.73999994756e-06	0.000885224997344325	2.17999999346e-06	0.0138029770538316	9.07999999273599e-18	0.0116705369533179	3.13999997802e-07	0.000274449001921143	6.58004610552164e-18	2.65634407131845e-18	1.16548732028598e-08	1e-18
+5:Ins:R:0	3.31000001575451e-18	3.9500000237e-18	8.83000002649e-05	8.57999995709999e-05	0.00475007097149957	0.00871678102615034	1e-18	0.000318328999045013	0.000165845999502462	0.0492106131919214	0.000666059999467151	0.0137906449448374	0.00259023098186838	0.00271214101898499	6.58004610552164e-18	0.00117258662949932	0.0146738819971304	0.0120240962046017
+5:Ins:R:1	0.0014431260068688	0.000135658000813948	0.00065622000196866	0.00213585198932074	0.00479343097123941	0.00540564301621693	1e-18	0.00976111397071666	0.00125399599623801	0.278059972084434	0.00115190999907847	0.00383426498466294	0.0135019519054863	0.0264555251851887	6.58004610552164e-18	0.0011011924574188	0.00491953232698964	0.00200401603410028
+5:Ins:R:2	0.000254832001212916	5.53000003318e-06	5.51000001653e-06	0.000222026998889865	0.000298795998207224	0.00132184300396553	8.83999994696e-06	0.000101152999696541	0.000102848999691453	0.00922198903596576	0.000366006999707194	0.00213001599147994	4.58999996787e-05	0.000488313003418191	1.18199012643727e-06	8.28266792667268e-07	4.6445807436868e-08	1e-18
+5:Ins:R:3	0.000237087001128456	9.77000005862e-05	3.32000000996e-05	7.58999996204999e-06	0.000165545999006724	2.88000000864e-05	4.45999997324e-06	7.08999997873e-05	8.01999997594e-05	0.00366078901427708	8.33999999332799e-07	0.00266048898935804	4.60999996773e-05	0.000103831000726817	1.621273088488e-06	2.65757325630755e-18	4.75565784473372e-08	1e-18
+5:Ins:R:4	0.000261865001246391	2.1500000129e-06	7.87000002361e-06	2.52999998735e-05	0.000126706999239758	4.83000001449e-05	1.05999999364e-05	6.73999997978e-06	5.04999998485e-05	0.00334072001302881	2.2499999982e-06	0.00159240699363037	2.42999998299e-06	0.000157593001103151	6.58004610552164e-18	2.65563975048453e-18	3.95567326568308e-08	1e-18
+5:Ins:R:5	0.00011983400057037	0.000115629000693774	3.48000001044e-06	0.000160228999198855	0.000626341996241948	6.17000001851e-05	4.27999997432e-06	0.000190550999428347	9.88999997033e-06	0.0027405910106883	1.839999998528e-06	0.00613606997545572	4.32999996969e-05	2.15000001505e-05	6.58004610552164e-18	2.65069544116599e-18	4.48283910156371e-08	1e-18
+2:Del:M:1	0.0011978150057012	0.000175553001053318	0.00693076402079229	0.188997489055013	0.0286879458278723	0.000632866001898598	0.00312705798123765	0.00491367198525898	0.00390097198829708	0.000638138002488738	0.000382063999694349	0.00265350298938599	0.00887240793789315	0.00264092501848648	6.58004610552164e-18	0.00137420087593352	0.00366896648521895	0.0180361443069025
+3:Del:M:1	8.1900000389817e-05	5.46000003276e-07	0.000344612001033836	0.00703415596482921	0.0131571469210571	0.000990097002970291	0.00025475999847144	0.00929033697212899	0.00301132799096602	0.00396085401544733	0.000200442999839646	0.0103283519586866	0.00114008299201942	0.00157517301102621	6.58004610552164e-18	0.000764470282770831	0.0048873035805209	1e-18
+3:Del:M:2	0.00147959300704237	0.00294406301766438	0.00030285000090855	0.049416600752917	0.00900420994597475	0.00443363001330089	0.00463563897218617	0.00430269298709192	0.00154330199537009	0.0193041640752862	0.000301743999758605	0.00606115797575537	0.000450305996847858	0.00323693502265854	6.58004610552164e-18	0.000980363974341033	0.00368107551554234	1e-18
+4:Del:M:1	8.38000003988604e-05	0.00014700500088203	7.35000002204999e-05	0.0109817189450914	0.0087322019476068	0.00274539500823619	0.000183826998897038	0.00580955098257135	0.00192772099421684	0.000179039000698252	9.07999999273599e-18	0.00377171798491313	0.00127079799110441	8.2000000574e-06	6.58004610552164e-18	0.000504717900987043	0.0109797305945076	0.00601204810230084
+4:Del:M:2	0.000145479000692432	0.000550614003303684	0.000340216001020648	0.0294838768525806	0.00604718696371688	0.00868271002604813	0.00101904099388575	0.00159158699522524	0.00329744799010766	0.000387083001509624	9.07999999273599e-18	0.00457315298170739	0.000159722998881939	0.000950493006653451	6.58004610552164e-18	0.000409799520784757	0.00489044160567025	1e-18
+4:Del:M:3	0.000160684000764803	0.000693566004161396	0.000130463000391389	0.0488666397556668	0.00344244197934535	0.00477309401431928	0.00071732499569605	0.00109834199670497	0.00254407899236776	8.220000032058e-05	0.000789867999368105	0.000525262997898948	0.000270577998105954	0.00223043401561304	6.58004610552164e-18	0.000402367649801	0.00365961696983014	1e-18
+5:Del:M:1	8.16000003883891e-07	0.000624963003749778	0.0013696340041089	0.000453120997734395	0.00861707294829757	0.0710665792131997	2.35999998584e-05	0.280724260157827	3.53999998938e-05	0.00133028700518812	0.000282793999773765	0.000563377997746488	0.0117407769178146	0.00655170604586194	0.000660877105516124	0.00536204916184987	0.0207713280418549	0.0300602405115042
+5:Del:M:2	2.38000001132801e-10	0.000117708000706248	0.00175127200525382	0.00013623199931884	0.00785102095289388	0.253108347759325	0.000245768998525386	0.12361016262917	0.000221235999336292	0.000124027000483705	0.000372770999701783	1.41999999432e-17	0.00705542095061205	0.00449863403149044	0.000432409450773911	0.00502171467340586	0.012290058300929	0.0220441763751031
+5:Del:M:3	2.33000001109003e-12	5.67000003402e-05	0.000774958002324873	0.00111223599443882	0.00715797495705215	0.216806032650418	6.15999996304e-05	0.0461304078616088	0.000570906998287279	5.650000022035e-05	0.000750126999399897	0.000323567998705728	0.00216598398483811	0.00140448700983141	0.00026612607242146	0.00333883980844505	0.00859625789862607	0.00601204810230084
+5:Del:M:4	3.88000001846752e-05	0.000462842002777052	0.000640555001921665	0.00365294598173527	0.00249254898504471	0.120483943361452	6.81999995908e-05	0.0163672559508982	0.000448307998655076	0.000104022000405686	0.000130277999895778	0.000277662998889348	0.000281735998027848	0.000100143000701001	0.000247928132326935	0.00132989736605632	0.00489791342344186	0.00400803206820056
+5:Del:M:5	0.000665116003165733	0.00236731901420391	0.00036297000108891	4.5599999772e-05	0.0011123669933258	0.099282999297849	0.00173836498956981	0.0128148819615554	5.40999998377e-18	0.0414089311614948	0.000518954999584836	0.00665797297336811	0.0131319069080767	0.000931512006520584	0.000139828818249736	0.00160162870855497	0.00607563604544812	1e-18
diff --git a/SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_SBS288_Signatures.txt b/SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_SBS288_Signatures.txt
new file mode 100644
index 0000000..6d66a6e
--- /dev/null
+++ b/SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_SBS288_Signatures.txt
@@ -0,0 +1,97 @@
+MutationType	SBS1	SBS2	SBS4	SBS5	SBS7c	SBS8	SBS10c	SBS12	SBS13	SBS16	SBS18	SBS19	SBS21	SBS22	SBS27	SBS28	SBS30	SBS32	SBS36	SBS39	SBS40	SBS44	SBS51	SBS90	SBS92
+A[C>A]A	0.00088616	0.00000058	0.04219650	0.01199760	0.00483041	0.04409822	0.00433145	0.00452059	0.00181992	0.01599504	0.05153386	0.00126938	0.00015699	0.00601276	0.00520782	0.00078391	0.00179968	0.02229777	0.02519378	0.01170152	0.02820375	0.00000000	0.14096391	0.00220165	0.01132934
+A[C>A]C	0.00228040	0.00014800	0.03329724	0.00943811	0.00115010	0.04779807	0.01483022	0.00113015	0.00072097	0.00289910	0.01581039	0.00064069	0.00235989	0.00009544	0.00473802	0.00252969	0.00050591	0.01879812	0.00831795	0.00715093	0.01340178	0.00015004	0.00168957	0.00070822	0.00974473
+A[C>A]G	0.00017703	0.00005230	0.01559871	0.00184963	0.00037703	0.00461981	0.00065712	0.00054007	0.00026399	0.00101968	0.00243160	0.00024588	0.00029399	0.00076535	0.00078267	0.00035296	0.00009128	0.00445955	0.00223945	0.00267035	0.00292039	0.00000092	0.00479877	0.00013857	0.00469657
+A[C>A]T	0.00128023	0.00009780	0.02949755	0.00660868	0.00196016	0.04699810	0.01312776	0.00122016	0.00034798	0.01059671	0.02141407	0.00057072	0.00062097	0.00172079	0.00271886	0.00396952	0.00055590	0.01459854	0.01789558	0.00740096	0.01480197	0.00578146	0.02119457	0.00175516	0.00775798
+A[C>G]A	0.00186033	0.00000000	0.00688943	0.01009798	0.00112009	0.00432983	0.00034763	0.00122016	0.00386983	0.00173946	0.00173114	0.00318845	0.00001690	0.00166076	0.00131945	0.00015398	0.00106981	0.00198980	0.00183955	0.04730615	0.01220162	0.00318081	0.00395899	0.00050807	0.00305586
+A[C>G]C	0.00122022	0.00013300	0.00283976	0.00569886	0.00031903	0.00294988	0.00032513	0.00064208	0.00095096	0.00200938	0.00259170	0.00178913	0.00071897	0.00019509	0.00176926	0.00022397	0.00046692	0.00202980	0.00166959	0.02250293	0.00868115	0.00023306	0.00453884	0.00027713	0.00168986
+A[C>G]G	0.00011502	0.00001520	0.00127989	0.00171966	0.00000000	0.00028599	0.00004243	0.00007511	0.00026399	0.00084674	0.00192126	0.00061570	0.00000000	0.00023111	0.00000000	0.00000000	0.00013098	0.00112989	0.00049988	0.01360177	0.00225030	0.00003141	0.00196950	0.00004620	0.00090730
+A[C>G]T	0.00114020	0.00009120	0.00354971	0.01009798	0.00193016	0.00570977	0.00051631	0.00144019	0.00399982	0.01149643	0.00408268	0.00213896	0.00006190	0.00006203	0.00131945	0.00008329	0.00073087	0.00174983	0.00190953	0.04340564	0.01460194	0.00329083	0.00089977	0.00092377	0.00411591
+A[C>T]A	0.02500444	0.00006110	0.00869928	0.03259348	0.00133011	0.00680972	0.00486707	0.00551072	0.00717968	0.00175945	0.00920605	0.02798638	0.00216990	0.00176081	0.01369426	0.00077691	0.10598120	0.08639137	0.00595853	0.00960125	0.01970262	0.08992278	0.03579084	0.00070802	0.02376637
+A[C>T]C	0.00632112	0.00138004	0.00417965	0.01789642	0.00768065	0.00281989	0.00524944	0.00212028	0.00000000	0.00372884	0.00465306	0.01409314	0.00391982	0.00022010	0.00541773	0.00337959	0.09038397	0.12298771	0.00327919	0.00404053	0.01210161	0.01690428	0.00564855	0.00029253	0.01409754
+A[C>T]G	0.36506477	0.00003270	0.00078294	0.00617876	0.00092708	0.00322987	0.01301999	0.00011802	0.00030299	0.00326899	0.01220802	0.00154925	0.00739965	0.00136063	0.00670719	0.00704915	0.01439745	0.03659634	0.00706825	0.00600078	0.00026704	0.01430362	0.00564855	0.00009240	0.00978578
+A[C>T]T	0.00958170	0.00186005	0.00424965	0.02199560	0.00748063	0.01249950	0.00615621	0.00238031	0.00031799	0.00599814	0.00797524	0.03678210	0.00004170	0.00061628	0.00447812	0.00505939	0.02929480	0.15198482	0.00430894	0.01280166	0.01690225	0.03030768	0.00319918	0.00064664	0.01645207
+A[T>A]A	0.00080014	0.00009590	0.00941922	0.00737852	0.01240104	0.01949921	0.00402006	0.00517068	0.00000000	0.02309283	0.00249164	0.00078562	0.00345984	0.06392938	0.14294012	0.00017198	0.00036294	0.00071293	0.00243940	0.00531069	0.00610081	0.00478121	0.11297108	0.06135367	0.01007203
+A[T>A]C	0.00223040	0.00087803	0.00352971	0.00692861	0.00342029	0.02129914	0.01364236	0.00271036	0.00006520	0.00773760	0.00087858	0.00025488	0.00564973	0.00701322	0.00145939	0.00047794	0.00039293	0.00088691	0.00142965	0.00288037	0.00444059	0.00260066	0.00134965	0.00035411	0.00358815
+A[T>A]G	0.00114020	0.00002550	0.01239897	0.00911818	0.00021102	0.02279908	0.00123009	0.00312041	0.00058997	0.00880727	0.00260171	0.00095154	0.00024799	0.06062786	0.00122948	0.00015198	0.00063789	0.00071193	0.00252938	0.00694090	0.00693092	0.00000108	0.03679058	0.00035411	0.00701173
+A[T>A]T	0.00018303	0.00000000	0.00420965	0.00619876	0.05070426	0.02499899	0.07177673	0.00282037	0.00060597	0.01099659	0.00784515	0.00065368	0.00159992	0.00251115	0.00253894	0.00169979	0.00048991	0.00084392	0.00306924	0.00612080	0.01070142	0.03080780	0.02949245	0.02346374	0.00918124
+A[T>C]A	0.00109019	0.00006170	0.00794934	0.04619076	0.00028802	0.00976961	0.01822254	0.07360964	0.00190992	0.24192493	0.00202133	0.00258874	0.01669922	0.02501150	0.00504789	0.00054893	0.00061089	0.00093591	0.00524870	0.01120146	0.01870249	0.01930489	0.00258934	0.00571197	0.08918805
+A[T>C]C	0.00304054	0.00002150	0.00071494	0.01339732	0.00053304	0.00500980	0.00907955	0.04030528	0.00014199	0.01289600	0.00209137	0.00059371	0.00999953	0.00089941	0.00184923	0.00044095	0.00045792	0.00070093	0.00168958	0.00564073	0.00734098	0.00324082	0.01929506	0.00018475	0.00463736
+A[T>C]G	0.00010602	0.00001320	0.00499959	0.03819236	0.00107009	0.00697972	0.01694303	0.07050924	0.00042798	0.06388018	0.00208137	0.00230888	0.00387982	0.00775356	0.00568762	0.00040495	0.00027695	0.00108989	0.00383905	0.00964125	0.01550206	0.02720689	0.00394899	0.00010777	0.04011199
+A[T>C]T	0.00574102	0.00015500	0.00155987	0.03829234	0.00265022	0.01489940	0.01277899	0.06380836	0.00095896	0.13595781	0.00424279	0.00173915	0.02559880	0.00075535	0.00258892	0.00059493	0.00054490	0.00060994	0.00511874	0.01360177	0.01940258	0.00026707	0.00186952	0.00286368	0.02956694
+A[T>G]A	0.00017203	0.00023801	0.00104991	0.00385923	0.01190100	0.00163993	0.00251924	0.00201026	0.00006140	0.01119653	0.00072147	0.00232887	0.00039198	0.00233107	0.00113952	0.00986881	0.00003899	0.00038596	0.00108973	0.00388050	0.00723096	0.00000002	0.00072281	0.00543484	0.00206966
+A[T>G]C	0.00020704	0.00007460	0.00015899	0.00259948	0.00105009	0.00066797	0.00097887	0.00066409	0.00000000	0.00440863	0.00085856	0.00188908	0.00043698	0.00005092	0.00095860	0.01729791	0.00010998	0.00042896	0.00062285	0.00297039	0.00705094	0.00003261	0.00408895	0.00004620	0.00035897
+A[T>G]G	0.00026805	0.00000205	0.00141988	0.00793841	0.00060405	0.00476981	0.00103877	0.00080811	0.00008250	0.00461857	0.00199131	0.00176914	0.00018699	0.00295136	0.00006767	0.00767907	0.00040993	0.00126987	0.00093577	0.00766100	0.00806107	0.00000747	0.02779289	0.00023094	0.00123837
+A[T>G]T	0.00011202	0.00000376	0.00021598	0.00482903	0.00000000	0.00073997	0.01305586	0.00128017	0.00031999	0.00795753	0.00184121	0.00161921	0.00006950	0.00004182	0.00025589	0.11498609	0.00079386	0.00000000	0.00098376	0.00642083	0.01800239	0.00142036	0.00212945	0.00204769	0.00354120
+C[C>A]A	0.00031206	0.00020801	0.08069330	0.00742851	0.00010901	0.04009838	0.01743293	0.00542071	0.00139994	0.01039677	0.07404865	0.00131936	0.00000000	0.00183084	0.00506788	0.00202975	0.00076786	0.00123988	0.05578622	0.01010131	0.02080277	0.00002841	0.00697821	0.00118550	0.01855035
+C[C>A]C	0.00179032	0.00009530	0.07969339	0.00613877	0.00309026	0.03879843	0.00967042	0.00428056	0.00096796	0.00902720	0.01961289	0.00076663	0.00259988	0.00443204	0.00222907	0.00010899	0.00038793	0.00491951	0.02019501	0.00906118	0.01470196	0.03030768	0.00316919	0.00044649	0.01395552
+C[C>A]G	0.00009322	0.00000000	0.02449797	0.00345931	0.00191016	0.00340986	0.00240461	0.00117015	0.00000433	0.00173946	0.01200789	0.00023589	0.00197991	0.00013606	0.00026589	0.00000000	0.00040693	0.00001660	0.00709825	0.00574075	0.00254034	0.00374095	0.00429890	0.00021601	0.00528203
+C[C>A]T	0.00000000	0.00042101	0.06899427	0.00648870	0.01350113	0.03299867	0.04488739	0.00110014	0.00000000	0.00248923	0.03632386	0.00003438	0.01909910	0.00011005	0.00309870	0.00020298	0.00029695	0.00266973	0.06048506	0.00603078	0.01470196	0.08672196	0.00506870	0.00101615	0.01254310
+C[C>G]A	0.00002410	0.00000000	0.00782935	0.00695861	0.00020602	0.00499980	0.00011020	0.00134018	0.00560975	0.00354890	0.00061340	0.00176914	0.00001970	0.00105048	0.00472802	0.00001440	0.00126977	0.00114989	0.00123969	0.02880374	0.00756101	0.00005361	0.00284927	0.00033871	0.00240959
+C[C>G]C	0.00007681	0.00035101	0.00686943	0.00906819	0.00226019	0.00545978	0.00020758	0.00089112	0.00064797	0.00453859	0.00226149	0.00180912	0.00027299	0.00078536	0.00125947	0.00007549	0.00079286	0.00082392	0.00136966	0.03770490	0.00935124	0.00002491	0.00011997	0.00007700	0.00396222
+C[C>G]G	0.00035206	0.00004870	0.00339972	0.00248950	0.00026202	0.00001050	0.00018022	0.00017302	0.00048798	0.00145955	0.00358235	0.00004808	0.00001010	0.00023911	0.00036085	0.00000000	0.00011998	0.00053695	0.00041890	0.01230160	0.00168022	0.00000000	0.00202948	0.00001540	0.00160101
+C[C>G]T	0.00000000	0.00006360	0.00681943	0.00952809	0.00424036	0.00548978	0.00023827	0.00156020	0.00639972	0.00961702	0.00379249	0.00321843	0.00017299	0.00032015	0.00026789	0.00000000	0.00101982	0.00049495	0.00208948	0.04020523	0.01390185	0.00008642	0.00260933	0.00029253	0.00536600
+C[C>T]A	0.00200035	0.00432012	0.01269895	0.01939612	0.00271023	0.00266989	0.00376117	0.00659086	0.00001930	0.00716778	0.01170769	0.11894211	0.00134994	0.00121056	0.01739271	0.00029196	0.10998049	0.01689831	0.00674833	0.00911118	0.01960261	0.00357090	0.00322917	0.00061585	0.03660735
+C[C>T]C	0.00027005	0.00017000	0.01149905	0.01899620	0.00597050	0.00401984	0.00664382	0.00025403	0.00134994	0.00283912	0.00676444	0.09195525	0.00515976	0.00319147	0.00713701	0.00020997	0.10298173	0.02839716	0.00667835	0.00386050	0.01730230	0.00286072	0.00469880	0.00030792	0.03476131
+C[C>T]G	0.19603478	0.00277008	0.00330973	0.01749650	0.00894075	0.00148994	0.00947159	0.00004091	0.00198991	0.00069079	0.01681104	0.01569236	0.00621971	0.00042620	0.00749686	0.00254969	0.01679702	0.01119888	0.00532868	0.00757098	0.00236031	0.01550393	0.02069470	0.00020015	0.01082396
+C[C>T]T	0.00019603	0.00145004	0.01599867	0.02309538	0.02060173	0.01449941	0.00983726	0.00338044	0.00144994	0.01929401	0.00665437	0.25787449	0.00032498	0.00160074	0.00714701	0.00331960	0.04619181	0.04279572	0.00574858	0.00699091	0.02160287	0.00504128	0.00405896	0.00036951	0.04532348
+C[T>A]A	0.00004301	0.00024301	0.01439880	0.00353929	0.00347029	0.01899923	0.00067318	0.00054607	0.00020899	0.00320900	0.00054236	0.00009595	0.00000619	0.12805886	0.33086140	0.00013998	0.00021396	0.00032497	0.00125969	0.00494064	0.00109014	0.00001240	0.00610844	0.10206109	0.00704592
+C[T>A]C	0.00039307	0.00024401	0.01219899	0.00518896	0.01340113	0.02919882	0.00279160	0.00560073	0.00034198	0.00569823	0.00306201	0.00040280	0.00068797	0.05512534	0.00280882	0.00134984	0.00077686	0.00064994	0.00145964	0.00644084	0.00762101	0.00325082	0.00148962	0.00035411	0.00393189
+C[T>A]G	0.00032406	0.00014900	0.03249730	0.00500900	0.00096108	0.02759889	0.00090019	0.00141018	0.00022599	0.00102968	0.00321211	0.00029386	0.00012499	0.16807725	0.00439816	0.00080590	0.00058690	0.00140986	0.00213947	0.00680088	0.00346046	0.00058215	0.00651833	0.00036951	0.01024476
+C[T>A]T	0.00026005	0.00000000	0.01179902	0.00429914	0.04870409	0.04179831	0.00335317	0.00150020	0.00052298	0.00652797	0.00226149	0.00021789	0.00000000	0.06032773	0.00542773	0.00102988	0.00061189	0.00066293	0.00195952	0.00827108	0.00928123	0.00001380	0.00361907	0.10052148	0.00644868
+C[T>C]A	0.00000000	0.00030201	0.00517957	0.01329734	0.00757064	0.00238990	0.01197149	0.04540595	0.00004740	0.01069668	0.00038625	0.00045178	0.01149946	0.00674310	0.00489795	0.00131984	0.00126977	0.00059294	0.00149963	0.00734095	0.01090145	0.01460370	0.00417893	0.00477281	0.03076459
+C[T>C]C	0.00250044	0.00002850	0.00235980	0.01039792	0.00358030	0.00699972	0.00978329	0.04970651	0.00012199	0.00316902	0.00246162	0.00008136	0.00281987	0.00134062	0.00571760	0.00261968	0.00137976	0.00092691	0.00187954	0.00791103	0.00987131	0.00320081	0.07108180	0.00021555	0.00401078
+C[T>C]G	0.00036006	0.00000000	0.00549954	0.02079584	0.00217018	0.00125995	0.01462779	0.03740490	0.00000000	0.00960702	0.00162107	0.00049776	0.01439932	0.00203093	0.00565763	0.00248970	0.00126977	0.00183982	0.00184954	0.00777101	0.01050140	0.03380856	0.00292925	0.00020015	0.01412281
+C[T>C]T	0.00004261	0.00018601	0.00255979	0.01489702	0.04310362	0.00645974	0.01924899	0.04590601	0.00011200	0.01549519	0.00256168	0.00039081	0.02169898	0.00053625	0.00389837	0.00036696	0.00409927	0.00108989	0.00215947	0.00859112	0.01360181	0.00771195	0.00663830	0.00635861	0.01367035
+C[T>G]A	0.00003551	0.00015300	0.00086993	0.00258948	0.00328028	0.00121995	0.01081415	0.00089312	0.00004140	0.00395877	0.00011107	0.00071365	0.00000435	0.00491226	0.00000000	0.01459823	0.00019796	0.00005809	0.00047788	0.00530069	0.00335045	0.00023406	0.00277929	0.00894516	0.00092840
+C[T>G]C	0.00021204	0.00015500	0.00044096	0.00460908	0.00558047	0.00194992	0.00229700	0.00114015	0.00000282	0.00107966	0.00199131	0.00208898	0.00005440	0.00088040	0.00038084	0.02209733	0.00021496	0.00044996	0.00056586	0.00739096	0.00567075	0.00253064	0.00255934	0.00004620	0.00041878
+C[T>G]G	0.00012802	0.00012100	0.00378969	0.00612877	0.00119010	0.00469981	0.00686483	0.00059308	0.00000000	0.00223931	0.00293193	0.00132935	0.00002010	0.00803369	0.00040283	0.01549812	0.00007849	0.00108989	0.00088678	0.00983128	0.00559074	0.00347088	0.00592848	0.00012317	0.00209052
+C[T>G]T	0.00017103	0.00020301	0.00119990	0.00729854	0.00340029	0.00057398	0.03001246	0.00034405	0.00005550	0.00253921	0.00414272	0.00219893	0.00018499	0.00119055	0.00143940	0.10098778	0.00026495	0.00067593	0.00106974	0.00494064	0.01310174	0.00038410	0.00229941	0.00970026	0.00054519
+G[C>A]A	0.00158028	0.00008620	0.03159738	0.01019796	0.00105009	0.02419902	0.00841771	0.00198026	0.00094896	0.00860733	0.10907166	0.00081360	0.00213990	0.00223103	0.01079548	0.00015598	0.00094283	0.00450955	0.06768328	0.00688089	0.01420189	0.00000000	0.00393899	0.00096996	0.00893931
+G[C>A]C	0.00033906	0.00000000	0.03479711	0.00764847	0.00074206	0.02619894	0.00743436	0.00041705	0.00045098	0.00424868	0.01731137	0.00027187	0.00706967	0.00173080	0.01239481	0.00101988	0.00049391	0.00361964	0.01919526	0.00695090	0.01020136	0.00467118	0.00327916	0.00041570	0.00782492
+G[C>A]G	0.00058710	0.00001390	0.01529873	0.00233953	0.00000000	0.00273989	0.00089221	0.00044706	0.00016399	0.00135958	0.00756497	0.00020490	0.00168992	0.00051524	0.00162932	0.00003950	0.00000000	0.00087691	0.00482881	0.00453059	0.00255034	0.00060515	0.00427890	0.00012300	0.00445574
+G[C>A]T	0.00000000	0.00005120	0.02119824	0.00681864	0.00036303	0.02689891	0.01205754	0.00002750	0.00006150	0.00579820	0.06234096	0.00027287	0.00889958	0.00055125	0.00740690	0.00015798	0.00086185	0.00326967	0.06898296	0.00589077	0.01080144	0.01130286	0.00344912	0.00040030	0.00655609
+G[C>G]A	0.00000959	0.00006540	0.00528956	0.00467906	0.00018202	0.00257990	0.00017011	0.00056407	0.00149993	0.00104967	0.00063542	0.00130936	0.00038798	0.00140064	0.00141941	0.00018298	0.00051491	0.00087591	0.00088578	0.02400312	0.00506067	0.00021906	0.00340913	0.00043109	0.00234881
+G[C>G]C	0.00016403	0.00026101	0.00574952	0.00507898	0.00047304	0.00238990	0.00038835	0.00028904	0.00047898	0.00308904	0.00134088	0.00128937	0.00141993	0.00093043	0.00134943	0.00000000	0.00025595	0.00089991	0.00107973	0.02130277	0.00537071	0.00119030	0.00113971	0.00029253	0.00216132
+G[C>G]G	0.00016603	0.00000000	0.00329973	0.00150970	0.00018002	0.00048798	0.00003285	0.00009541	0.00024099	0.00008127	0.00063942	0.00059671	0.00011699	0.00021110	0.00000000	0.00000000	0.00011698	0.00006859	0.00017196	0.00986128	0.00119016	0.00000000	0.00026693	0.00004620	0.00089337
+G[C>G]T	0.00000000	0.00013400	0.00303975	0.00671866	0.00128011	0.00485980	0.00015468	0.00050407	0.00269988	0.00322900	0.00123081	0.00031984	0.00020699	0.00045521	0.00455809	0.00000000	0.00039893	0.00022798	0.00104974	0.03240421	0.00698093	0.00185047	0.00284927	0.00026173	0.00152748
+G[C>T]A	0.00444079	0.00000000	0.00408966	0.01939612	0.00015701	0.00027599	0.00361387	0.00448059	0.00717968	0.00649798	0.00968636	0.06097033	0.00931956	0.00238109	0.01419405	0.00324961	0.04969118	0.02259774	0.00371908	0.00803104	0.01430190	0.09552419	0.00446886	0.00044649	0.01282583
+G[C>T]C	0.00009282	0.00000013	0.00445963	0.02159568	0.00000951	0.00024499	0.00902991	0.00182024	0.00092096	0.00528836	0.00817537	0.03968069	0.01959908	0.00187086	0.02009158	0.00018798	0.06098918	0.03789621	0.00339916	0.00450059	0.01160154	0.08142062	0.00308921	0.00032332	0.01351091
+G[C>T]G	0.21803869	0.00000000	0.00048196	0.01229754	0.00003430	0.00190992	0.00922420	0.00007461	0.00017799	0.00116964	0.01480973	0.00320844	0.00004340	0.00000000	0.00936608	0.00021497	0.00523907	0.01039896	0.00569859	0.00548071	0.00000000	0.04961257	0.00427890	0.00016900	0.00593888
+G[C>T]T	0.00003841	0.00005040	0.00380968	0.01859628	0.00075806	0.00460981	0.01038312	0.00267035	0.00126994	0.00671792	0.00669440	0.10894698	0.00804962	0.00176081	0.00758682	0.00010199	0.01769686	0.05319469	0.00362910	0.00861112	0.01270169	0.06661687	0.00594848	0.00050807	0.01684613
+G[T>A]A	0.00008121	0.00000000	0.00921923	0.00366927	0.00173015	0.01279948	0.00190232	0.00082611	0.00000670	0.00093971	0.00160105	0.00018891	0.00116995	0.05372469	0.10995394	0.00011599	0.00032894	0.00878912	0.00087978	0.00496064	0.00265035	0.00116029	0.02039478	0.03896766	0.00562396
+G[T>A]C	0.00012902	0.00013100	0.00359970	0.00290942	0.00227019	0.01349945	0.00688939	0.00181024	0.00012999	0.00060781	0.00195128	0.00007776	0.00325985	0.01020469	0.00002349	0.00011799	0.00018197	0.00821918	0.00063084	0.00352046	0.00343046	0.00236060	0.00384901	0.00016936	0.00192496
+G[T>A]G	0.00024604	0.00006380	0.01309891	0.00410918	0.00000000	0.01559937	0.00193028	0.00251033	0.00004700	0.00554828	0.00183120	0.00048576	0.00074197	0.03751724	0.00156934	0.00007169	0.00009858	0.01309869	0.00116971	0.00667087	0.00441059	0.00221056	0.00428890	0.00015396	0.00599620
+G[T>A]T	0.00025805	0.00006280	0.00551954	0.00321936	0.02030171	0.02809886	0.01281500	0.00091512	0.00035798	0.00096570	0.00346227	0.00028286	0.00093696	0.00932429	0.00000000	0.00032396	0.00019097	0.00615938	0.00111972	0.00409053	0.00577077	0.00318081	0.00014596	0.01662785	0.00411785
+G[T>C]A	0.00105019	0.00000000	0.00289976	0.01409718	0.00000000	0.00259989	0.01273936	0.07110932	0.00028699	0.00205936	0.00070847	0.00095354	0.22298953	0.00072133	0.00477800	0.00049094	0.00093483	0.00913909	0.00233942	0.00747097	0.00601080	0.02700684	0.00117970	0.00328009	0.02920934
+G[T>C]C	0.00190034	0.00002740	0.00117990	0.00793841	0.00042304	0.00261989	0.00606970	0.03040398	0.00018199	0.00118963	0.00226149	0.00037082	0.06629689	0.00124057	0.00195918	0.00058693	0.00055490	0.00766923	0.00139965	0.00689090	0.00458061	0.00116029	0.00226942	0.00009240	0.00268576
+G[T>C]G	0.00117021	0.00010700	0.00236980	0.01499700	0.00023202	0.00280989	0.01272993	0.04150544	0.00019499	0.00427867	0.00398262	0.00095254	0.11699451	0.00058127	0.00122948	0.00073091	0.00050091	0.00961904	0.00183955	0.00574075	0.00565075	0.01730438	0.00455883	0.00007700	0.00925981
+G[T>C]T	0.00007131	0.00001250	0.00075494	0.01369726	0.00707059	0.00628975	0.01056995	0.04630607	0.00000000	0.00239926	0.00315207	0.00235885	0.13299376	0.00083438	0.00374843	0.00085090	0.00044492	0.01289871	0.00264935	0.00751098	0.00731097	0.01110281	0.00400897	0.00132407	0.01267295
+G[T>G]A	0.00000000	0.00020901	0.00059795	0.00251950	0.00248021	0.00130995	0.00035506	0.00041205	0.00008770	0.00090172	0.00087057	0.00063569	0.00028599	0.00159073	0.00000000	0.00115986	0.00018797	0.00114989	0.00018495	0.00333043	0.00249033	0.00000000	0.00218944	0.00635861	0.00055049
+G[T>G]C	0.00000000	0.00013300	0.00025298	0.00170966	0.00166014	0.00065597	0.00062031	0.00021303	0.00000000	0.00090072	0.00003702	0.00070266	0.00053297	0.00023611	0.00005078	0.00192977	0.00035294	0.00073993	0.00031292	0.00580075	0.00224030	0.00001830	0.00529864	0.00004620	0.00029423
+G[T>G]G	0.00034806	0.00003710	0.00242980	0.00529894	0.00603051	0.00396984	0.00061425	0.00049606	0.00042598	0.00067479	0.00583383	0.00050975	0.00021299	0.00045021	0.00473802	0.00312962	0.00137976	0.00300970	0.00152962	0.00772100	0.00445059	0.00010303	0.07618050	0.00023094	0.00154435
+G[T>G]T	0.00001460	0.00000000	0.00025198	0.00234953	0.00675057	0.00128995	0.00747367	0.00016502	0.00000289	0.00238926	0.00214141	0.00034083	0.00258988	0.00001961	0.00229904	0.02059751	0.00015997	0.00078492	0.00048888	0.00594077	0.00548073	0.00280071	0.00208947	0.00288008	0.00019960
+T[C>A]A	0.00006581	0.00063902	0.03979670	0.00785843	0.00252021	0.02979880	0.06018580	0.00348046	0.07899652	0.01079665	0.07384852	0.00137933	0.00145993	0.00078436	0.00707704	0.01429827	0.00069588	0.00972903	0.14096518	0.00598078	0.02600346	0.00085322	0.03569086	0.00201690	0.01484858
+T[C>A]C	0.00253045	0.00017000	0.04689611	0.00916817	0.01420119	0.02509899	0.00854316	0.00288038	0.02939871	0.00586818	0.04362866	0.00112945	0.00023599	0.00174080	0.00626737	0.00045195	0.00024296	0.00928907	0.07718094	0.00786102	0.02100279	0.00222056	0.00285927	0.00078520	0.01283178
+T[C>A]G	0.00000000	0.00008530	0.01089910	0.00229954	0.00000000	0.00189992	0.00265737	0.00050507	0.01209947	0.00148954	0.01270835	0.00028486	0.00006830	0.00000000	0.00144939	0.00012898	0.00008259	0.00237976	0.01469637	0.00301039	0.00317042	0.00000032	0.00453884	0.00007700	0.00239317
+T[C>A]T	0.00000588	0.00044001	0.04129657	0.01269746	0.00373031	0.03189871	0.18880397	0.00235031	0.03549844	0.00924713	0.12208021	0.00137933	0.00000000	0.00039618	0.00980589	0.00055693	0.00066488	0.00963904	0.20794864	0.00655085	0.02410321	0.01660421	0.00036991	0.00144724	0.01318626
+T[C>G]A	0.00000000	0.00000000	0.00357970	0.00780844	0.00194016	0.00146994	0.00025875	0.00096913	0.31698604	0.00250922	0.00214141	0.00174915	0.00065397	0.00356164	0.00286880	0.00011499	0.00012698	0.00000000	0.00397902	0.03470451	0.01250166	0.00067317	0.00204948	0.00064664	0.01945116
+T[C>G]C	0.00020304	0.00009870	0.00594951	0.00759848	0.00461039	0.00133995	0.00039568	0.00155020	0.06349720	0.00522838	0.00464305	0.00311848	0.00063097	0.00152070	0.00310870	0.00013598	0.00098583	0.00109989	0.00240940	0.03670477	0.01410188	0.00000940	0.00360908	0.00032332	0.00408750
+T[C>G]G	0.00006941	0.00004120	0.00182985	0.00170966	0.00000875	0.00007820	0.00001039	0.00021403	0.01379939	0.00043886	0.00089959	0.00044079	0.00006270	0.00038118	0.00001279	0.00002460	0.00010598	0.00099690	0.00030193	0.00962125	0.00174023	0.00000000	0.00215945	0.00006160	0.00029840
+T[C>G]T	0.00156028	0.00118003	0.00337972	0.01249750	0.01230103	0.00024899	0.00034715	0.00305040	0.36898375	0.02849116	0.00318209	0.00160922	0.00068697	0.00038818	0.00212911	0.00014298	0.00010898	0.00069193	0.00758813	0.05070659	0.02370315	0.00259066	0.00332915	0.00143184	0.02298928
+T[C>T]A	0.00111020	0.53601548	0.00373969	0.02029594	0.01730145	0.00503980	0.00240343	0.00552072	0.00692969	0.00635803	0.01140749	0.04387864	0.00359983	0.00159073	0.01879213	0.00483941	0.09798262	0.02479752	0.01069736	0.00388050	0.03000399	0.00140035	0.00169956	0.00211006	0.01710459
+T[C>T]C	0.00003731	0.09730281	0.00698942	0.02299540	0.01370115	0.00025199	0.00901811	0.00264035	0.00447980	0.00367886	0.01140749	0.02498784	0.00008070	0.00132061	0.00798665	0.00412950	0.13397623	0.03869613	0.00685831	0.00528069	0.02310307	0.00225057	0.00176955	0.00098535	0.01736940
+T[C>T]G	0.11001952	0.04420128	0.00028098	0.01589682	0.00004640	0.00004170	0.00859142	0.00008851	0.00118995	0.00301906	0.01180776	0.00431790	0.00031699	0.00003772	0.00460807	0.00173979	0.01469739	0.00984902	0.00388904	0.00486063	0.00212028	0.00000000	0.00648834	0.00029253	0.00359965
+T[C>T]T	0.00000000	0.30000866	0.00721940	0.02099580	0.00232019	0.00526979	0.01280128	0.00612080	0.00141994	0.02209314	0.00375247	0.06286940	0.00007310	0.00000000	0.01189502	0.00198976	0.05249069	0.06699331	0.00832794	0.00423055	0.02240298	0.00302077	0.04238915	0.00277131	0.02458275
+T[T>A]A	0.00672119	0.00042201	0.00887926	0.00630874	0.01540129	0.01149954	0.00996265	0.00375049	0.00029599	0.01229618	0.01080710	0.00049376	0.00025699	0.07183301	0.05277789	0.00018798	0.00028195	0.00051195	0.00245939	0.00669087	0.00713095	0.00696176	0.02009486	0.35700939	0.00817815
+T[T>A]C	0.00000000	0.00019201	0.00430964	0.00413917	0.03420287	0.01949921	0.00247466	0.00645085	0.00023199	0.00466855	0.00273179	0.00047477	0.00079496	0.02361085	0.00004708	0.00124985	0.00024096	0.00244976	0.00101975	0.00369048	0.01030137	0.00002071	0.00257934	0.00087758	0.00284712
+T[T>A]G	0.00002800	0.00005010	0.00953921	0.00478904	0.01220103	0.01289948	0.00056580	0.00277036	0.00018799	0.00517839	0.00179118	0.00037282	0.00009850	0.07323366	0.00000000	0.00032096	0.00018997	0.00175982	0.00087178	0.00546071	0.00502067	0.00000502	0.00402897	0.00060045	0.00675146
+T[T>A]T	0.00225040	0.00020501	0.00561953	0.00874825	0.27902345	0.03789847	0.00483127	0.00525069	0.00006200	0.00715778	0.00710467	0.00067267	0.00007640	0.03011384	0.00192919	0.00571931	0.00070088	0.00071093	0.00269933	0.01070139	0.02100279	0.01390352	0.00637837	0.16267575	0.00604418
+T[T>C]A	0.00025505	0.00000000	0.00240980	0.01799640	0.03020254	0.00207992	0.01699877	0.08611128	0.00002210	0.01299597	0.00180118	0.00123940	0.08419605	0.00463213	0.00171928	0.00130984	0.00054390	0.00089691	0.00296927	0.00594077	0.01020136	0.01990504	0.00445886	0.01011527	0.03453614
+T[T>C]C	0.00339060	0.00004350	0.00050296	0.00970806	0.02090176	0.00263989	0.01675970	0.04630607	0.00002490	0.00366886	0.00618406	0.00055273	0.05479743	0.00000000	0.00348854	0.00204975	0.00028595	0.00121988	0.00227944	0.00644084	0.00755100	0.01050266	0.00392899	0.00044649	0.00435020
+T[T>C]G	0.00041607	0.00011700	0.00173986	0.01269746	0.01290108	0.00000000	0.01511532	0.04000524	0.00009980	0.00722776	0.00326214	0.00107947	0.02759870	0.00122056	0.00114952	0.00140983	0.00020296	0.00168983	0.00137966	0.00498065	0.00601080	0.01910484	0.00246937	0.00013857	0.01293528
+T[T>C]T	0.00433077	0.00003580	0.00063595	0.01849630	0.08810740	0.00456982	0.01992081	0.05970782	0.00053098	0.00838740	0.00337222	0.00146928	0.04069809	0.00000000	0.00152936	0.00205975	0.00044492	0.00068393	0.00279931	0.00948123	0.01020136	0.03710940	0.02129455	0.00400011	0.01428691
+T[T>G]A	0.00000000	0.00001670	0.00037697	0.00521896	0.01930162	0.00000000	0.00873077	0.00163021	0.00018399	0.00977697	0.00069646	0.00165919	0.00046498	0.00506233	0.00118950	0.04229488	0.00011798	0.00002260	0.00078781	0.00839109	0.00846113	0.00000000	0.00254935	0.01858316	0.00220843
+T[T>G]C	0.00005511	0.00007040	0.00017399	0.00655869	0.01740146	0.00113995	0.00095216	0.00113015	0.00000000	0.00550829	0.00210138	0.00201902	0.00037898	0.00075235	0.00027988	0.03569568	0.00009638	0.00022398	0.00074382	0.00508066	0.01140152	0.00000000	0.00346911	0.00018475	0.00030058
+T[T>G]G	0.00058310	0.00009540	0.00231981	0.00693861	0.00764064	0.00308988	0.00110836	0.00087511	0.00003670	0.00523837	0.00145095	0.00206899	0.00013099	0.00557256	0.00234902	0.01399831	0.00081286	0.00081792	0.00090178	0.00728095	0.00866115	0.00091723	0.00275929	0.00029253	0.00174284
+T[T>G]T	0.00000000	0.00000000	0.00056795	0.01349730	0.02170182	0.00099596	0.02511471	0.00221029	0.00001890	0.01579510	0.00516339	0.00422794	0.00000000	0.00059527	0.00013994	0.47894205	0.00888842	0.00063494	0.00180955	0.01090142	0.02500333	0.00900228	0.00290926	0.00833022	0.00179435
diff --git a/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_DINUC.txt b/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_DINUC.txt
new file mode 100644
index 0000000..d366109
--- /dev/null
+++ b/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_DINUC.txt
@@ -0,0 +1,79 @@
+MutationType	DBS78A	DBS78B	DBS78C	DBS78D	DBS78E	DBS78F	DBS78G	DBS78H	DBS78I	DBS78J
+AC>CA	0.00000147	0.00000000	0.00000329	0.00000000	0.00261989	0.00571955	0.02153659	0.06845419	0.00030925	0.00000228
+AC>CG	0.00000284	0.00892548	0.00000437	0.00000798	0.00000069	0.00000001	0.00000000	0.00000204	0.00000025	0.00000070
+AC>CT	0.00010998	0.01718593	0.00000148	0.00000000	0.00000065	0.00366879	0.00000000	0.01275529	0.00000273	0.00000511
+AC>GA	0.00000000	0.00109701	0.00544209	0.05812111	0.02324790	0.02254448	0.00728015	0.00904214	0.00684010	0.00000000
+AC>GG	0.00048407	0.00000000	0.00000000	0.00000000	0.00203472	0.00000000	0.00000000	0.00392303	0.00840148	0.00386878
+AC>GT	0.00694808	0.00299568	0.00000303	0.00000020	0.00000172	0.00026038	0.00135918	0.00000000	0.00000059	0.00728515
+AC>TA	0.00000983	0.00000009	0.00000000	0.00000000	0.00342719	0.00000121	0.09485586	0.00000969	0.00000000	0.00000465
+AC>TG	0.00000000	0.01540884	0.00001054	0.00000000	0.00000000	0.00000000	0.00000068	0.00000043	0.00000149	0.00765458
+AC>TT	0.00000000	0.00507150	0.02308200	0.01971575	0.01880993	0.00000000	0.00000479	0.02339362	0.00000000	0.00000000
+AT>CA	0.00000974	0.00000252	0.01142595	0.00839327	0.00000385	0.00466129	0.00000000	0.00671193	0.00000000	0.00000000
+AT>CC	0.00000000	0.00000158	0.00000016	0.00000035	0.00055699	0.00806448	0.00000036	0.00000131	0.00000012	0.00193727
+AT>CG	0.00000036	0.00000149	0.00000985	0.00001344	0.00000025	0.00000035	0.00000038	0.00133039	0.00050399	0.00000200
+AT>GA	0.00000116	0.00002941	0.02062550	0.00000000	0.00001183	0.00000020	0.00000480	0.02243761	0.00000000	0.00000000
+AT>GC	0.00000026	0.00000305	0.00000100	0.00000014	0.00000104	0.00001287	0.00106898	0.00071367	0.00000000	0.00250981
+AT>TA	0.00000298	0.01635354	0.00752523	0.00001861	0.00000000	0.00000110	0.05224749	0.02062796	0.00000000	0.00000194
+CC>AA	0.73048081	0.00000215	0.00001758	0.00001503	0.00000000	0.00000000	0.00000829	0.00000661	0.00000071	0.00000000
+CC>AG	0.06461847	0.00000000	0.00000000	0.00000369	0.22419740	0.00000000	0.02591369	0.00000634	0.00000000	0.05554190
+CC>AT	0.09868636	0.00000000	0.00000000	0.00000000	0.03261745	0.04605249	0.29471854	0.01424732	0.00000333	0.00000000
+CC>GA	0.00000722	0.00072244	0.11616418	0.00000744	0.00000141	0.02105989	0.00000000	0.02772145	0.00504706	0.00000000
+CC>GG	0.00000000	0.00000000	0.00000000	0.00000534	0.00001705	0.00000941	0.00001292	0.00000238	0.00870196	0.02531215
+CC>GT	0.00954260	0.00000000	0.02447773	0.00000000	0.00352000	0.02693450	0.00000000	0.00000000	0.03117193	0.00465944
+CC>TA	0.00000000	0.00000045	0.01900926	0.00000543	0.08785604	0.00000186	0.00000000	0.00000000	0.00748219	0.00003917
+CC>TG	0.00000000	0.00000000	0.00315705	0.00007233	0.02000636	0.00138601	0.00203417	0.00000000	0.00907845	0.01097589
+CC>TT	0.00002819	0.00000000	0.00000000	0.00000000	0.23172492	0.04662632	0.03761693	0.00000000	0.00001644	0.00000000
+CG>AT	0.00000017	0.00000982	0.00194881	0.00000000	0.00000074	0.00000035	0.00978945	0.00593920	0.00001695	0.00000579
+CG>GC	0.00000113	0.00000390	0.00000149	0.00000328	0.00000259	0.00000187	0.00000202	0.00000362	0.00000184	0.00000429
+CG>GT	0.00000150	0.00000185	0.00684268	0.00000263	0.00000135	0.00000056	0.00000000	0.00004975	0.00000264	0.00607964
+CG>TA	0.00000000	0.00000769	0.00000118	0.00000079	0.00000320	0.00000582	0.01567103	0.00000794	0.00000233	0.00000007
+CG>TC	0.00000021	0.00222110	0.00000007	0.00150583	0.00000005	0.00000018	0.00105064	0.00000259	0.00000684	0.00001866
+CG>TT	0.01388507	0.00000000	0.00000000	0.00716817	0.01108264	0.00482162	0.00000000	0.00000251	0.00580945	0.00001939
+CT>AA	0.00000680	0.00000184	0.00000324	0.00000000	0.00000428	0.00000270	0.00000089	0.00000201	0.00000504	0.34973149
+CT>AC	0.00000587	0.00000000	0.00000432	0.00000000	0.01404173	0.00000000	0.00778041	0.04901339	0.00000000	0.00000000
+CT>AG	0.00000000	0.00286278	0.01068026	0.00000139	0.00000000	0.00000000	0.03238640	0.03484700	0.01507633	0.02645819
+CT>GA	0.00000021	0.00567938	0.00340008	0.00000000	0.00295854	0.00382013	0.00000000	0.00000000	0.00447512	0.02785006
+CT>GC	0.00000000	0.00000281	0.00000112	0.00000000	0.01188001	0.00000041	0.00000190	0.01391582	0.00000591	0.00000619
+CT>GG	0.00207746	0.00720478	0.00065408	0.00000000	0.00710877	0.00000000	0.00000000	0.00000000	0.00906911	0.00865848
+CT>TA	0.00000111	0.00000000	0.02806435	0.02143513	0.03267128	0.00000000	0.00000313	0.00003041	0.02159274	0.00000000
+CT>TC	0.00955025	0.00986049	0.00000000	0.00000000	0.00353625	0.00000000	0.01929773	0.02053345	0.01934073	0.00000000
+CT>TG	0.00000041	0.00000000	0.03361531	0.00512703	0.00000000	0.00000169	0.00000000	0.00193496	0.01225479	0.00576188
+GC>AA	0.00000000	0.00000034	0.00000000	0.71012924	0.00000332	0.00000000	0.00001707	0.00000065	0.00001214	0.00001176
+GC>AG	0.00000000	0.01007852	0.01515107	0.00000000	0.03980388	0.00000601	0.00000000	0.15257923	0.02723572	0.00000000
+GC>AT	0.00000000	0.06795256	0.01499227	0.01095995	0.00000000	0.04335346	0.00000000	0.01762519	0.02818550	0.03019662
+GC>CA	0.00000000	0.00000219	0.05278736	0.00000061	0.00001980	0.00000250	0.00000204	0.00000242	0.05837211	0.00001217
+GC>CG	0.00000005	0.00000708	0.00498098	0.00000169	0.00000207	0.00000231	0.00000000	0.00000147	0.00000000	0.00001175
+GC>TA	0.00000000	0.00000000	0.03367862	0.00524511	0.00000000	0.00000059	0.01185212	0.00000000	0.00000000	0.01188881
+TA>AT	0.00000000	0.06133877	0.00000516	0.00000087	0.00000209	0.00000247	0.00000234	0.00000421	0.00000076	0.10762208
+TA>CG	0.00000666	0.00000183	0.00000000	0.00415522	0.00000046	0.00030303	0.00000105	0.00000065	0.00000076	0.00113827
+TA>CT	0.00000000	0.01517569	0.00495748	0.01033683	0.00337413	0.00000000	0.05912824	0.00000000	0.01904872	0.00000000
+TA>GC	0.00000004	0.00002353	0.00054380	0.00101246	0.00000000	0.00000382	0.00000066	0.00000082	0.00001129	0.00000078
+TA>GG	0.00000054	0.00855225	0.00000070	0.00000022	0.00201732	0.00001598	0.00000000	0.00000061	0.00189303	0.00099233
+TA>GT	0.00001628	0.00000000	0.00000695	0.00187763	0.00475160	0.00972107	0.00000774	0.02298998	0.00000000	0.00251593
+TC>AA	0.00593679	0.71242356	0.00000373	0.04773591	0.00000000	0.01752494	0.01139382	0.04219836	0.04171562	0.00000529
+TC>AG	0.00000000	0.00000176	0.00000002	0.00016403	0.08717492	0.04836594	0.05267184	0.00000388	0.00000000	0.00000313
+TC>AT	0.00000000	0.00000010	0.00000000	0.00000287	0.00000000	0.59588779	0.00000328	0.00000470	0.00001237	0.00001131
+TC>CA	0.00000000	0.00000653	0.00000274	0.00001136	0.00000000	0.00000263	0.00000000	0.00000140	0.47796377	0.00000000
+TC>CG	0.00000000	0.00000329	0.00000151	0.00000679	0.00000247	0.00311342	0.00504271	0.00000086	0.01185574	0.00442680
+TC>CT	0.00000000	0.00000000	0.03580317	0.00000511	0.00001907	0.00000000	0.00000365	0.12346432	0.01961413	0.00000000
+TC>GA	0.00000478	0.00000343	0.04007517	0.00629371	0.02449010	0.00000000	0.13281813	0.04668890	0.01377318	0.00001240
+TC>GG	0.00000000	0.00001389	0.00000079	0.00138462	0.00000091	0.01576089	0.00416124	0.00000204	0.00000000	0.00662647
+TC>GT	0.00000321	0.00000295	0.00000515	0.00000000	0.01411504	0.03554469	0.00000686	0.00000000	0.00000000	0.02985200
+TG>AA	0.01024123	0.01229957	0.00480819	0.00000000	0.01188901	0.02511361	0.01945381	0.00000000	0.02169794	0.00000000
+TG>AC	0.00000208	0.00000000	0.00948890	0.00000417	0.00000058	0.00000058	0.00000021	0.00000000	0.01416991	0.01845281
+TG>AT	0.00000360	0.00000349	0.00000000	0.00264629	0.00000000	0.00000485	0.03214480	0.16871673	0.00000000	0.11886213
+TG>CA	0.00004174	0.00001086	0.05523082	0.00000253	0.00000318	0.00000000	0.00000160	0.00000000	0.00000000	0.00000345
+TG>CC	0.00000478	0.00000818	0.00439489	0.00000000	0.00000138	0.00276350	0.01352855	0.00544008	0.00000000	0.00384940
+TG>CT	0.00000000	0.00000000	0.36978957	0.00000000	0.00000000	0.00000000	0.01382549	0.00000000	0.06583124	0.00001413
+TG>GA	0.00000044	0.01490150	0.00000000	0.01920313	0.00000503	0.00000129	0.00000000	0.00000786	0.00000319	0.00000196
+TG>GC	0.00000018	0.00000430	0.00000000	0.00953069	0.00000000	0.00000000	0.00000042	0.00000487	0.00289548	0.00000126
+TG>GT	0.01252718	0.00000000	0.03309386	0.01765405	0.00000000	0.00000000	0.00000220	0.00000000	0.00000000	0.02948568
+TT>AA	0.02338501	0.00000245	0.00000000	0.00642950	0.01956971	0.00039865	0.00000000	0.02260809	0.01756849	0.07047894
+TT>AC	0.00363956	0.00000000	0.00000000	0.01840221	0.00179790	0.00000360	0.00000000	0.00881959	0.00000000	0.00000000
+TT>AG	0.00000000	0.00150799	0.00001114	0.00000199	0.01686120	0.00000000	0.00000000	0.03169381	0.00745688	0.00000000
+TT>CA	0.00769458	0.00000067	0.00000000	0.00000000	0.02331978	0.00000234	0.00000071	0.00467688	0.00000203	0.00000360
+TT>CC	0.00000308	0.00001247	0.00000205	0.00000113	0.01181544	0.00000000	0.01267778	0.00000638	0.00000000	0.00000122
+TT>CG	0.00000024	0.00000000	0.00000087	0.00153483	0.00000660	0.00149547	0.00000000	0.00289364	0.00000000	0.00000274
+TT>GA	0.00000986	0.00000000	0.00400506	0.00000000	0.00000000	0.00494303	0.00484005	0.00000000	0.00542833	0.01433959
+TT>GC	0.00001347	0.00000169	0.00000023	0.00364029	0.00000251	0.00000013	0.00000050	0.00701484	0.00002978	0.00000075
+TT>GG	0.00000000	0.00000094	0.00000049	0.00000063	0.00500177	0.00000090	0.00176367	0.00487749	0.00000000	0.00477949
diff --git a/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_INDEL.txt b/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_INDEL.txt
new file mode 100644
index 0000000..0cf6c88
--- /dev/null
+++ b/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_INDEL.txt
@@ -0,0 +1,84 @@
+MutationType	ID83A	ID83B	ID83C	ID83D	ID83E	ID83F	ID83G	ID83H	ID83I	ID83J
+1:Del:C:0	0.00674724	0.01159681	0.04699048	0.04966229	0.00183957	0.00856840	0.02232269	0.14135217	0.04463867	0.04867948
+1:Del:C:1	0.00108693	0.00737513	0.01007768	0.00495988	0.00009146	0.00228318	0.01215533	0.09025281	0.01557178	0.02194138
+1:Del:C:2	0.00124122	0.00185276	0.00491051	0.00000000	0.00109848	0.00494971	0.00658875	0.06253425	0.00439988	0.00985495
+1:Del:C:3	0.00638089	0.00035392	0.00000000	0.00000000	0.00000000	0.00217557	0.00341689	0.04991282	0.00000000	0.00000000
+1:Del:C:4	0.01236945	0.00000000	0.00000000	0.00197124	0.00024858	0.00000000	0.00289917	0.02179487	0.00206072	0.00000000
+1:Del:C:5	0.03466907	0.00008563	0.00265640	0.00000000	0.00027915	0.00457282	0.00000000	0.01320263	0.00161637	0.00000000
+1:Del:T:0	0.00342382	0.00743756	0.02069410	0.01074418	0.00183679	0.00935806	0.00987162	0.05532641	0.05944337	0.01889334
+1:Del:T:1	0.00096276	0.00177145	0.01787989	0.00306505	0.00042775	0.00000000	0.00662211	0.03810403	0.02481110	0.03038465
+1:Del:T:2	0.00284452	0.00539679	0.01382517	0.00836597	0.00000000	0.00309290	0.00888963	0.05885588	0.01351843	0.01501817
+1:Del:T:3	0.01342695	0.00548521	0.02196768	0.00260430	0.00135785	0.00000000	0.00890432	0.05738604	0.01287598	0.01491739
+1:Del:T:4	0.03640765	0.00249476	0.03238496	0.00000000	0.00060217	0.00000000	0.00946085	0.05286055	0.00664835	0.01591670
+1:Del:T:5	0.60755777	0.00448124	0.45350213	0.00198826	0.00000000	0.00000000	0.00000000	0.00000000	0.00000000	0.15439365
+1:Ins:C:0	0.00147310	0.00000000	0.00697851	0.01203856	0.00000000	0.01493751	0.00215153	0.00031624	0.00361695	0.24632404
+1:Ins:C:1	0.00000000	0.00092671	0.00129405	0.00271658	0.00000001	0.00586697	0.00086496	0.01254698	0.00179856	0.01291346
+1:Ins:C:2	0.00000906	0.00085422	0.00171762	0.00065489	0.00009861	0.00204197	0.00046628	0.01072575	0.00144278	0.00072511
+1:Ins:C:3	0.00067042	0.00183253	0.00016400	0.00079145	0.00000001	0.00424446	0.00079393	0.00121408	0.00382837	0.00095265
+1:Ins:C:4	0.00263910	0.00319595	0.00052810	0.00000000	0.00000001	0.00736108	0.00058411	0.00042623	0.00213852	0.00122180
+1:Ins:C:5	0.01813698	0.02016725	0.00000000	0.00000000	0.00000000	0.01569429	0.00012840	0.03259507	0.00388634	0.00918315
+1:Ins:T:0	0.00083156	0.00492863	0.00298103	0.00414594	0.00000005	0.01199296	0.00284018	0.00932390	0.00925724	0.01344618
+1:Ins:T:1	0.00035184	0.00000000	0.00000000	0.00000000	0.00044646	0.00000000	0.00101033	0.00000000	0.18815484	0.00000000
+1:Ins:T:2	0.00264346	0.00231027	0.00060419	0.00335859	0.00074592	0.00000000	0.00117120	0.00000000	0.06676456	0.00305000
+1:Ins:T:3	0.00154129	0.00354280	0.00196986	0.00273931	0.00078897	0.00333425	0.00249063	0.01392798	0.02546399	0.00527501
+1:Ins:T:4	0.00285466	0.01086241	0.00491968	0.00000000	0.00009438	0.00534346	0.00041800	0.00843735	0.00980186	0.01129940
+1:Ins:T:5	0.18469098	0.75628534	0.00000668	0.41375459	0.00307644	0.07286056	0.03463716	0.09867414	0.25967973	0.05775655
+2:Del:R:0	0.00187337	0.00418514	0.02525003	0.00876488	0.00023153	0.01804969	0.00463304	0.00467962	0.00628129	0.00500763
+2:Del:R:1	0.00137008	0.01217353	0.04492474	0.00242615	0.00095068	0.00927489	0.00714470	0.00144999	0.00967716	0.00298831
+2:Del:R:2	0.00119424	0.00234604	0.01165660	0.00250801	0.00036684	0.00072519	0.00112636	0.00365654	0.00673968	0.00455667
+2:Del:R:3	0.00547071	0.00013980	0.00053828	0.00135611	0.00039916	0.00054689	0.00054368	0.00210826	0.00145716	0.00134165
+2:Del:R:4	0.00389115	0.00000000	0.00035074	0.00000000	0.00001313	0.00001592	0.00009684	0.00063038	0.00183843	0.00040621
+2:Del:R:5	0.01247196	0.00069884	0.00000000	0.02865156	0.00000003	0.00000000	0.00000000	0.00000000	0.00000000	0.00867049
+3:Del:R:0	0.00005213	0.00174208	0.00379390	0.00497192	0.00037696	0.00253005	0.00191160	0.00493973	0.00451068	0.00049450
+3:Del:R:1	0.00148096	0.00620716	0.04524366	0.00011250	0.00032233	0.00882225	0.00455223	0.00336714	0.01031586	0.01091264
+3:Del:R:2	0.00044406	0.00095298	0.01224328	0.00142282	0.00033784	0.00424697	0.00054073	0.00036998	0.00003530	0.00081977
+3:Del:R:3	0.00019206	0.00000000	0.00186638	0.00000000	0.00000000	0.00126148	0.00000000	0.00147472	0.00021600	0.00016045
+3:Del:R:4	0.00009507	0.00042983	0.00126104	0.00036369	0.00001957	0.00000000	0.00031874	0.00000000	0.00000000	0.00000000
+3:Del:R:5	0.00056692	0.00000000	0.00035892	0.00238667	0.00000000	0.00000000	0.00000000	0.00042342	0.00000705	0.00177516
+4:Del:R:0	0.00000166	0.00195661	0.00336884	0.00374389	0.00001937	0.00310634	0.00378597	0.00228100	0.00115091	0.00216551
+4:Del:R:1	0.00043380	0.00125138	0.02821536	0.00312930	0.00000060	0.00640388	0.00350603	0.00342605	0.00283728	0.00615261
+4:Del:R:2	0.00000952	0.00023507	0.00464922	0.00153050	0.00005970	0.00047011	0.00041843	0.00000000	0.00175782	0.00008851
+4:Del:R:3	0.00010982	0.00016548	0.00091952	0.00227838	0.00010068	0.00017528	0.00000000	0.00008410	0.00000000	0.00000000
+4:Del:R:4	0.00008511	0.00000000	0.00100105	0.00000000	0.00000001	0.00111779	0.00000000	0.00000000	0.00021757	0.00000000
+4:Del:R:5	0.00012849	0.00022729	0.00048527	0.00000000	0.00001805	0.00000000	0.00015510	0.00007262	0.00000000	0.00023056
+5:Del:R:0	0.00007876	0.00540368	0.00716089	0.01546313	0.00372613	0.01988345	0.08819893	0.02176802	0.02466097	0.02901001
+5:Del:R:1	0.00056406	0.00158559	0.01260296	0.04112989	0.00190984	0.08082169	0.00844321	0.00644140	0.01941291	0.01022865
+5:Del:R:2	0.00092034	0.00000000	0.00653713	0.02879211	0.00000000	0.05119465	0.00320712	0.00184130	0.00114127	0.00447754
+5:Del:R:3	0.00155703	0.00000000	0.00119808	0.02747293	0.00013140	0.02494466	0.00005774	0.00000000	0.00085862	0.00000000
+5:Del:R:4	0.00048125	0.00000000	0.00193344	0.01672283	0.00023577	0.02247201	0.00037862	0.00014449	0.00000000	0.00000000
+5:Del:R:5	0.00002035	0.00000000	0.00000000	0.01523992	0.00021838	0.00570121	0.00012370	0.00361266	0.00000000	0.00001596
+2:Ins:R:0	0.00085350	0.00277769	0.00000000	0.01178023	0.00014689	0.02714711	0.00000000	0.00000000	0.00868537	0.04143614
+2:Ins:R:1	0.00000000	0.00228333	0.00250878	0.00203880	0.00033492	0.00813723	0.00211205	0.00481372	0.00692081	0.00463030
+2:Ins:R:2	0.00007962	0.00210142	0.00137950	0.00115155	0.00011238	0.00529120	0.00076698	0.00246804	0.00712070	0.00000000
+2:Ins:R:3	0.00062381	0.00088725	0.00095776	0.00011319	0.00000001	0.00219785	0.00000000	0.00046558	0.00282409	0.00000000
+2:Ins:R:4	0.00260210	0.00452856	0.00031794	0.00038946	0.00000061	0.00279497	0.00000000	0.00028431	0.00032691	0.00272016
+2:Ins:R:5	0.01132653	0.02797898	0.01883186	0.00144747	0.00023237	0.00165461	0.00512497	0.00259540	0.00914044	0.00458003
+3:Ins:R:0	0.00000000	0.00047041	0.00072067	0.00392220	0.00023558	0.00871099	0.00002922	0.00515977	0.00031106	0.00852936
+3:Ins:R:1	0.00000000	0.00315263	0.00151051	0.00127929	0.00000002	0.00416675	0.00178954	0.00569510	0.00892886	0.00159266
+3:Ins:R:2	0.00000000	0.00000000	0.00112588	0.00051289	0.00000001	0.00110712	0.00048538	0.00135847	0.00090636	0.00087649
+3:Ins:R:3	0.00004362	0.00004636	0.00003454	0.00000000	0.00000002	0.00215588	0.00008375	0.00000000	0.00000000	0.00000000
+3:Ins:R:4	0.00011752	0.00002384	0.00000000	0.00039545	0.00000001	0.00000000	0.00000000	0.00000000	0.00053787	0.00003038
+3:Ins:R:5	0.00075977	0.00252070	0.00108322	0.00010459	0.00008356	0.00018572	0.00000000	0.00000000	0.00047041	0.00099113
+4:Ins:R:0	0.00003505	0.00168374	0.00031828	0.00007468	0.00068413	0.01399481	0.00047588	0.00000000	0.00251761	0.01268110
+4:Ins:R:1	0.00000000	0.00495487	0.00000000	0.00250883	0.00000001	0.00362340	0.00299832	0.00392978	0.00971432	0.00104605
+4:Ins:R:2	0.00000960	0.00000000	0.00040203	0.00013246	0.00000000	0.00164182	0.00008299	0.00078326	0.00065313	0.00027887
+4:Ins:R:3	0.00006263	0.00017340	0.00016679	0.00014827	0.00000000	0.00149955	0.00004288	0.00052682	0.00012831	0.00033544
+4:Ins:R:4	0.00008534	0.00055864	0.00012747	0.00051198	0.00001628	0.00093071	0.00000000	0.00055837	0.00007306	0.00015806
+4:Ins:R:5	0.00018297	0.00181880	0.00006981	0.00047031	0.00000000	0.00176446	0.00008544	0.00154716	0.00071746	0.00072751
+5:Ins:R:0	0.00060730	0.00425173	0.00056108	0.02249992	0.00266247	0.16125050	0.01663313	0.00444270	0.00104187	0.03731134
+5:Ins:R:1	0.00000000	0.01456800	0.00168358	0.04746508	0.00000000	0.08555024	0.00811248	0.01155266	0.02125402	0.01372325
+5:Ins:R:2	0.00001995	0.00022966	0.00029856	0.04411641	0.00000000	0.04143803	0.00145872	0.00165218	0.00000000	0.00302023
+5:Ins:R:3	0.00000509	0.00019284	0.00000000	0.03845190	0.00026404	0.02916216	0.00000000	0.00125103	0.00000000	0.00330269
+5:Ins:R:4	0.00000635	0.00001810	0.00000000	0.03098329	0.00000000	0.01821689	0.00000000	0.00174526	0.00000000	0.00571224
+5:Ins:R:5	0.00000734	0.00007090	0.00000000	0.01470750	0.00000001	0.00243756	0.00000012	0.00047713	0.00021617	0.00014844
+2:Del:M:1	0.00318157	0.00734682	0.03698332	0.00793849	0.00030899	0.02993641	0.00540059	0.00603509	0.00231285	0.01775440
+3:Del:M:1	0.00007097	0.00271064	0.00407196	0.00093878	0.00000001	0.00556136	0.00328655	0.00257056	0.00390176	0.00000000
+3:Del:M:2	0.00067782	0.00294940	0.02514553	0.00197587	0.00036884	0.00924273	0.00537020	0.00572889	0.00714778	0.00055689
+4:Del:M:1	0.00000000	0.00155958	0.00575280	0.00250824	0.00012608	0.00059906	0.00357415	0.00421453	0.00106006	0.00000000
+4:Del:M:2	0.00006004	0.00221497	0.01147007	0.00301363	0.00068409	0.00100779	0.00504680	0.00350372	0.00638198	0.00129848
+4:Del:M:3	0.00021244	0.00276835	0.01742504	0.00255002	0.00045355	0.00926673	0.00681203	0.00324324	0.00202166	0.00232367
+5:Del:M:1	0.00039773	0.00812254	0.00287658	0.01111833	0.00251454	0.01830422	0.14885432	0.01576996	0.01066440	0.01752814
+5:Del:M:2	0.00000553	0.00186733	0.00191291	0.00000000	0.00447169	0.01377537	0.22747125	0.01222196	0.00823257	0.01939502
+5:Del:M:3	0.00041275	0.00000153	0.00000000	0.00573843	0.00524932	0.00829772	0.18340366	0.00276090	0.00880327	0.00549993
+5:Del:M:4	0.00016904	0.00099129	0.00030265	0.00277366	0.00418151	0.00464939	0.10176031	0.00010183	0.00206829	0.00734764
+5:Del:M:5	0.00093043	0.00123787	0.00034890	0.00421053	0.95439736	0.03385711	0.00090747	0.00000097	0.01038220	0.00281411
diff --git a/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_SBS1536.txt b/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_SBS1536.txt
new file mode 100644
index 0000000..4727931
--- /dev/null
+++ b/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_SBS1536.txt
@@ -0,0 +1,1537 @@
+MutationType	SBS1536A	SBS1536B	SBS1536C	SBS1536D	SBS1536E	SBS1536F	SBS1536G
+AA[C>A]AA	0.00075521	0.00187657	0.00260924	0.00183700	0.00275470	0.00348200	0.00275615
+AA[C>A]AC	0.00016908	0.00080838	0.00031155	0.00050100	0.00042021	0.00028233	0.00040531
+AA[C>A]AG	0.00022544	0.00114038	0.00124620	0.00062625	0.00154076	0.00225860	0.00081063
+AA[C>A]AT	0.00027053	0.00145797	0.00062309	0.00066799	0.00163414	0.00065876	0.00048637
+AA[C>A]CA	0.00032688	0.00073619	0.00194720	0.00091850	0.00266132	0.00178806	0.00113488
+AA[C>A]CC	0.00058614	0.00086611	0.00062310	0.00033399	0.00116724	0.00178806	0.00048637
+AA[C>A]CG	0.00003382	0.00004330	0.00027261	0.00000001	0.00000001	0.00000002	0.00008107
+AA[C>A]CT	0.00049596	0.00075063	0.00132409	0.00050100	0.00158745	0.00037642	0.00105382
+AA[C>A]GA	0.00007890	0.00004330	0.00003895	0.00029225	0.00000001	0.00009412	0.00016213
+AA[C>A]GC	0.00000000	0.00011548	0.00003895	0.00000001	0.00042021	0.00000002	0.00016213
+AA[C>A]GG	0.00003382	0.00001444	0.00000001	0.00000001	0.00000001	0.00000002	0.00016214
+AA[C>A]GT	0.00002254	0.00011548	0.00023366	0.00012525	0.00023345	0.00000002	0.00000001
+AA[C>A]TA	0.00037197	0.00059184	0.00058416	0.00075150	0.00046690	0.00065876	0.0000810 
+AA[C>A]TC	0.00061996	0.00046191	0.00046732	0.00091851	0.00074703	0.00094108	0.00048638
+AA[C>A]TG	0.00061996	0.00054853	0.00073993	0.00104376	0.00060696	0.00122341	0.00016213
+AA[C>A]TT	0.00060868	0.00155901	0.00202508	0.00200401	0.00149407	0.00112930	0.00032423
+AA[C>G]AA	0.00019162	0.00105377	0.00120726	0.00083500	0.00112055	0.00131751	0.00121595
+AA[C>G]AC	0.00004509	0.00020209	0.00023366	0.00037575	0.00014007	0.00000002	0.00032425
+AA[C>G]AG	0.00006763	0.00111152	0.00124620	0.00112725	0.00037352	0.00028232	0.00064850
+AA[C>G]AT	0.00014653	0.00030314	0.00023366	0.00104376	0.00060697	0.00018821	0.00064851
+AA[C>G]CA	0.00009017	0.00073620	0.00112937	0.00066800	0.00051359	0.00075287	0.00024318
+AA[C>G]CC	0.00004509	0.00028871	0.00031155	0.00000001	0.00028014	0.00000001	0.00048638
+AA[C>G]CG	0.00003382	0.00002887	0.00007789	0.00000001	0.00000001	0.00000002	0.00000002
+AA[C>G]CT	0.00001127	0.00049080	0.00035049	0.00045925	0.00051359	0.00056465	0.00000001
+AA[C>G]GA	0.00003382	0.00015879	0.00011683	0.00008350	0.00014007	0.00000002	0.00000001
+AA[C>G]GC	0.00000000	0.00007218	0.00000001	0.00000001	0.00014007	0.00000002	0.00000002
+AA[C>G]GG	0.00000000	0.00005774	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+AA[C>G]GT	0.00003382	0.00002887	0.00000001	0.00000001	0.00009338	0.00000002	0.00008107
+AA[C>G]TA	0.00018035	0.00082281	0.00054521	0.00100200	0.00093379	0.00009411	0.00056744
+AA[C>G]TC	0.00011272	0.00036088	0.00007789	0.00008350	0.00070035	0.00000002	0.00032425
+AA[C>G]TG	0.00022544	0.00046193	0.00112938	0.00020875	0.00079373	0.00018821	0.00040531
+AA[C>G]TT	0.00025925	0.00050523	0.00097360	0.00066800	0.00079373	0.00065875	0.00097276
+AA[C>T]AA	0.00164570	0.00108261	0.00101253	0.00029224	0.00172751	0.00235270	0.00154020
+AA[C>T]AC	0.00114974	0.00043303	0.00105149	0.00020875	0.00121393	0.00075286	0.00081063
+AA[C>T]AG	0.00152171	0.00096713	0.00077887	0.00020874	0.00144738	0.00141162	0.00137807
+AA[C>T]AT	0.00139772	0.00242511	0.00323234	0.00158650	0.00163414	0.00094107	0.00218869
+AA[C>T]CA	0.00140899	0.00066399	0.00089571	0.00050100	0.00088710	0.00141162	0.00089169
+AA[C>T]CC	0.00103702	0.00067844	0.00077888	0.00066800	0.00102717	0.00094108	0.00064850
+AA[C>T]CG	0.00014653	0.00000000	0.00000001	0.00008350	0.00009338	0.00000001	0.00056744
+AA[C>T]CT	0.00049596	0.00115481	0.00046732	0.00041749	0.00060697	0.00159984	0.00121595
+AA[C>T]GA	0.00312232	0.00128465	0.00307657	0.00267202	0.00238116	0.00348198	0.00470167
+AA[C>T]GC	0.00343794	0.00137125	0.00202508	0.00350702	0.00280137	0.00479951	0.00429636
+AA[C>T]GG	0.00337031	0.00105368	0.00070098	0.00221276	0.00275468	0.00254090	0.00421530
+AA[C>T]GT	0.00355066	0.00080827	0.00241452	0.00183701	0.00252123	0.00404663	0.00543125
+AA[C>T]TA	0.00047342	0.00060627	0.00070099	0.00041750	0.00056027	0.00047054	0.00072957
+AA[C>T]TC	0.00064250	0.00059183	0.00105148	0.00050100	0.00140069	0.00131752	0.00072957
+AA[C>T]TG	0.00089048	0.00054852	0.00085677	0.00066800	0.00051358	0.00018821	0.00081063
+AA[C>T]TT	0.00099193	0.00119811	0.00147987	0.00108550	0.00126062	0.00159984	0.00145913
+AA[T>A]AA	0.00032688	0.00138578	0.00140198	0.00133600	0.00088711	0.00094108	0.00113488
+AA[T>A]AC	0.00021417	0.00056298	0.00046733	0.00062625	0.00028014	0.00037643	0.00008106
+AA[T>A]AG	0.00016908	0.00041862	0.00003894	0.00020875	0.00074704	0.00037643	0.00032425
+AA[T>A]AT	0.00046215	0.00051966	0.00155776	0.00070975	0.00121393	0.00103519	0.00056744
+AA[T>A]CA	0.00080031	0.00059183	0.00097360	0.00029225	0.00042020	0.00075287	0.00016212
+AA[T>A]CC	0.00055232	0.00030313	0.00019472	0.00025050	0.00060697	0.00037643	0.00000001
+AA[T>A]CG	0.00005636	0.00000000	0.00015578	0.00000001	0.00004669	0.00000002	0.00000002
+AA[T>A]CT	0.00046215	0.00043305	0.00085677	0.00037575	0.00070035	0.00028232	0.00089170
+AA[T>A]GA	0.00019162	0.00044749	0.00070099	0.00020875	0.00074704	0.00037643	0.00032425
+AA[T>A]GC	0.00011272	0.00024540	0.00050627	0.00058451	0.00032683	0.00009412	0.00000001
+AA[T>A]GG	0.00007890	0.00043306	0.00089571	0.00016700	0.00042021	0.00065876	0.00040531
+AA[T>A]GT	0.00014653	0.00036088	0.00050627	0.00070976	0.00060697	0.00037644	0.00072957
+AA[T>A]TA	0.00511746	0.00111141	0.00194719	0.00079324	0.00326826	0.00159983	0.00072955
+AA[T>A]TC	0.00164570	0.00031754	0.00042838	0.00075150	0.00102717	0.00047054	0.00032425
+AA[T>A]TG	0.00146535	0.00038972	0.00054521	0.00054275	0.00093379	0.00000001	0.00056744
+AA[T>A]TT	0.00764237	0.00232391	0.00393332	0.00263025	0.00616302	0.00461128	0.00421528
+AA[T>C]AA	0.00185987	0.00154454	0.00147986	0.00200401	0.00200765	0.00075285	0.00235083
+AA[T>C]AC	0.00080031	0.00096715	0.00050626	0.00100200	0.00107386	0.00103518	0.00186446
+AA[T>C]AG	0.00118355	0.00095269	0.00089571	0.00062625	0.00102717	0.00225859	0.00243190
+AA[T>C]AT	0.00153298	0.00129913	0.00159669	0.00162825	0.00350173	0.00197625	0.00397211
+AA[T>C]CA	0.00067631	0.00053409	0.00058416	0.00096026	0.00065365	0.00084697	0.00056744
+AA[T>C]CC	0.00033816	0.00028870	0.00015577	0.00033400	0.00051359	0.00000001	0.00040532
+AA[T>C]CG	0.00004509	0.00000000	0.00000001	0.00008351	0.00000001	0.00000002	0.00000002
+AA[T>C]CT	0.00028180	0.00064958	0.00085676	0.00091850	0.00140069	0.00075286	0.00048638
+AA[T>C]GA	0.00304342	0.00099597	0.00120726	0.00125250	0.00084040	0.00094107	0.00154020
+AA[T>C]GC	0.00063123	0.00041861	0.00093465	0.00020875	0.00079372	0.00075286	0.00113489
+AA[T>C]GG	0.00153298	0.00059182	0.00035049	0.00037575	0.00032682	0.00084697	0.00129701
+AA[T>C]GT	0.00105956	0.00059182	0.00081782	0.00050100	0.00102717	0.00065875	0.00170233
+AA[T>C]TA	0.00056359	0.00108263	0.00198614	0.00225452	0.00079372	0.00150573	0.00105381
+AA[T>C]TC	0.00029307	0.00044748	0.00035049	0.00070975	0.00046690	0.00084697	0.00097276
+AA[T>C]TG	0.00061996	0.00101046	0.00066204	0.00083500	0.00088710	0.00018821	0.00121595
+AA[T>C]TT	0.00056359	0.00151569	0.00194719	0.00154475	0.00214773	0.00122339	0.00324254
+AA[T>G]AA	0.00019162	0.00031757	0.00062310	0.00033400	0.00270801	0.00122341	0.00056744
+AA[T>G]AC	0.00000000	0.00005774	0.00023366	0.00000001	0.00018676	0.00000002	0.00024319
+AA[T>G]AG	0.00009017	0.00018766	0.00054522	0.00096026	0.00000001	0.00009412	0.00000001
+AA[T>G]AT	0.00003381	0.00047637	0.00066205	0.00020875	0.00093380	0.00028233	0.00008107
+AA[T>G]CA	0.00007890	0.00017322	0.00015577	0.00008350	0.00074704	0.00065876	0.00000001
+AA[T>G]CC	0.00006763	0.00012991	0.00003895	0.00012525	0.00028014	0.00047054	0.00000001
+AA[T>G]CG	0.00000000	0.00002887	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+AA[T>G]CT	0.00010145	0.00012991	0.00023366	0.00000001	0.00023345	0.00000001	0.00048638
+AA[T>G]GA	0.00005636	0.00057741	0.00062310	0.00008350	0.00023345	0.00018822	0.00056744
+AA[T>G]GC	0.00002254	0.00017322	0.00011683	0.00037575	0.00032683	0.00009412	0.00000001
+AA[T>G]GG	0.00002254	0.00018766	0.00007789	0.00000001	0.00037352	0.00000002	0.00000001
+AA[T>G]GT	0.00002254	0.00023096	0.00062311	0.00058451	0.00004669	0.00037643	0.00000001
+AA[T>G]TA	0.00030434	0.00031756	0.00077888	0.00075151	0.00177421	0.00056464	0.00113489
+AA[T>G]TC	0.00021417	0.00021653	0.00023366	0.00020875	0.00116724	0.00000002	0.00000001
+AA[T>G]TG	0.00012399	0.00014435	0.00007789	0.00004175	0.00065366	0.00000001	0.00056744
+AA[T>G]TT	0.00033816	0.00054853	0.00136304	0.00025050	0.00196097	0.00169395	0.00081063
+AC[C>A]AA	0.00101447	0.00129916	0.00147987	0.00125250	0.00102717	0.00094108	0.00129700
+AC[C>A]AC	0.00107083	0.00059183	0.00070099	0.00054275	0.00037351	0.00056464	0.00105382
+AC[C>A]AG	0.00105956	0.00112592	0.00085676	0.00091850	0.00074703	0.00254093	0.00056743
+AC[C>A]AT	0.00129627	0.00077947	0.00112937	0.00083500	0.00042020	0.00150573	0.00154020
+AC[C>A]CA	0.00309978	0.00095267	0.00167459	0.00121075	0.00037350	0.00150573	0.00064849
+AC[C>A]CC	0.00069886	0.00046191	0.00136304	0.00016700	0.00042021	0.00084697	0.00048638
+AC[C>A]CG	0.00016908	0.00014435	0.00015578	0.00000001	0.00014007	0.00028233	0.00000001
+AC[C>A]CT	0.00152171	0.00096713	0.00089570	0.00066800	0.00168083	0.00122340	0.00121595
+AC[C>A]GA	0.00030434	0.00027427	0.00007789	0.00000001	0.00004669	0.00000002	0.00024319
+AC[C>A]GC	0.00015781	0.00014435	0.00015578	0.00000001	0.00000001	0.00000002	0.00008107
+AC[C>A]GG	0.00014654	0.00004330	0.00003895	0.00020875	0.00000001	0.00000002	0.00000002
+AC[C>A]GT	0.00016908	0.00023096	0.00011683	0.00025050	0.00009338	0.00000002	0.00032425
+AC[C>A]TA	0.00440733	0.00086603	0.00093465	0.00012524	0.00065363	0.00131751	0.00040530
+AC[C>A]TC	0.00497092	0.00069279	0.00116832	0.00066799	0.00023342	0.00084696	0.00064849
+AC[C>A]TG	0.00588395	0.00089487	0.00124620	0.00091849	0.00098046	0.00207037	0.00081062
+AC[C>A]TT	0.00495965	0.00138568	0.00183036	0.00129425	0.00121391	0.00263502	0.00137806
+AC[C>G]AA	0.00013526	0.00049080	0.00089571	0.00070975	0.00056028	0.00056465	0.00016213
+AC[C>G]AC	0.00001127	0.00027427	0.00019472	0.00012525	0.00018676	0.00000002	0.00000001
+AC[C>G]AG	0.00003382	0.00028871	0.00035049	0.00041750	0.00102718	0.00018822	0.00000001
+AC[C>G]AT	0.00013526	0.00037532	0.00054522	0.00008350	0.00014007	0.00065876	0.00000001
+AC[C>G]CA	0.00003382	0.00040419	0.00015577	0.00033400	0.00051359	0.00103520	0.00000001
+AC[C>G]CC	0.00001127	0.00011548	0.00007789	0.00020875	0.00023345	0.00009411	0.00048638
+AC[C>G]CG	0.00000000	0.00010105	0.00000001	0.00008350	0.00000001	0.00000002	0.00000002
+AC[C>G]CT	0.00005636	0.00049080	0.00019472	0.00037575	0.00000001	0.00000002	0.00016213
+AC[C>G]GA	0.00000000	0.00010105	0.00035050	0.00020875	0.00000001	0.00000002	0.00000001
+AC[C>G]GC	0.00000000	0.00005774	0.00003895	0.00008350	0.00000001	0.00000002	0.00024319
+AC[C>G]GG	0.00000000	0.00002887	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+AC[C>G]GT	0.00000000	0.00018766	0.00011683	0.00008350	0.00014007	0.00000002	0.00000001
+AC[C>G]TA	0.00016908	0.00072176	0.00050627	0.00054275	0.00065366	0.00028232	0.00081063
+AC[C>G]TC	0.00004509	0.00044750	0.00003894	0.00083501	0.00009338	0.00000002	0.00024319
+AC[C>G]TG	0.00005636	0.00054854	0.00042838	0.00083501	0.00046690	0.00047054	0.00016213
+AC[C>G]TT	0.00002254	0.00069289	0.00058416	0.00016700	0.00037352	0.00122341	0.00032426
+AC[C>T]AA	0.00048469	0.00092385	0.00105148	0.00070975	0.00084041	0.00028232	0.00016212
+AC[C>T]AC	0.00043960	0.00076506	0.00042838	0.00091850	0.00098048	0.00037643	0.00113488
+AC[C>T]AG	0.00056360	0.00056296	0.00136304	0.00041750	0.00121393	0.00094108	0.00089169
+AC[C>T]AT	0.00087921	0.00092384	0.00097359	0.00058450	0.00107386	0.00131751	0.00129701
+AC[C>T]CA	0.00151044	0.00102488	0.00085676	0.00070975	0.00032682	0.00094108	0.00089169
+AC[C>T]CC	0.00113846	0.00051965	0.00093465	0.00070975	0.00088710	0.00018821	0.00121595
+AC[C>T]CG	0.00003382	0.00028871	0.00000001	0.00020875	0.00014007	0.00000002	0.00000001
+AC[C>T]CT	0.00113846	0.00086610	0.00093465	0.00096025	0.00042020	0.00131752	0.00064850
+AC[C>T]GA	0.00167952	0.00064954	0.00105148	0.00096025	0.00172751	0.00084696	0.00235084
+AC[C>T]GC	0.00258127	0.00067839	0.00190825	0.00087675	0.00270800	0.00310557	0.00186445
+AC[C>T]GG	0.00165697	0.00051963	0.00081782	0.00058450	0.00121393	0.00159983	0.00243190
+AC[C>T]GT	0.00205149	0.00056292	0.00171354	0.00112726	0.00107386	0.00131749	0.00356680
+AC[C>T]TA	0.00060868	0.00059182	0.00097360	0.00050100	0.00121393	0.00188217	0.00089169
+AC[C>T]TC	0.00040579	0.00073619	0.00081782	0.00058450	0.00121393	0.00169395	0.00089169
+AC[C>T]TG	0.00061996	0.00096716	0.00097359	0.00100200	0.00093379	0.00037643	0.00056744
+AC[C>T]TT	0.00036070	0.00121256	0.00109043	0.00041749	0.00056027	0.00094108	0.00064850
+AC[T>A]AA	0.00009017	0.00038975	0.00054521	0.00025050	0.00042021	0.00056465	0.00024319
+AC[T>A]AC	0.00005636	0.00018766	0.00015577	0.00045925	0.00018676	0.00009412	0.00008107
+AC[T>A]AG	0.00004509	0.00037532	0.00007788	0.00000000	0.00023345	0.00018822	0.00000001
+AC[T>A]AT	0.00005636	0.00046193	0.00062310	0.00016700	0.00056028	0.00018822	0.00016213
+AC[T>A]CA	0.00032689	0.00036088	0.00035049	0.00033400	0.00051359	0.00000001	0.00040532
+AC[T>A]CC	0.00027053	0.00031757	0.00054521	0.00045925	0.00060696	0.00000001	0.00048638
+AC[T>A]CG	0.00001127	0.00004331	0.00015578	0.00000001	0.00004669	0.00000002	0.00000002
+AC[T>A]CT	0.00028180	0.00085168	0.00093465	0.00025049	0.00014007	0.00084697	0.00081063
+AC[T>A]GA	0.00005636	0.00051967	0.00035049	0.00025050	0.00018676	0.00000002	0.00024320
+AC[T>A]GC	0.00001127	0.00057741	0.00027260	0.00004175	0.00023345	0.00047054	0.00000001
+AC[T>A]GG	0.00003382	0.00054854	0.00038944	0.00008350	0.00014007	0.00018821	0.00064851
+AC[T>A]GT	0.00010145	0.00070733	0.00035049	0.00050100	0.00023345	0.00018823	0.00000001
+AC[T>A]TA	0.00021417	0.00060628	0.00109043	0.00033400	0.00056028	0.00065876	0.00032425
+AC[T>A]TC	0.00005636	0.00027427	0.00077888	0.00016700	0.00065366	0.00037643	0.00008107
+AC[T>A]TG	0.00023671	0.00044749	0.00077888	0.00037575	0.00088711	0.00047054	0.00000001
+AC[T>A]TT	0.00028180	0.00225191	0.00221980	0.00108549	0.00214773	0.00056464	0.00170232
+AC[T>C]AA	0.00071013	0.00030313	0.00015577	0.00016700	0.00084041	0.00028232	0.00064851
+AC[T>C]AC	0.00039452	0.00030313	0.00007789	0.00058450	0.00088711	0.00009411	0.00056744
+AC[T>C]AG	0.00067632	0.00043305	0.00031155	0.00012525	0.00018676	0.00009412	0.00016213
+AC[T>C]AT	0.00117228	0.00030312	0.00089571	0.00083501	0.00098048	0.00065876	0.00008106
+AC[T>C]CA	0.00066504	0.00041861	0.00011683	0.00066800	0.00074703	0.00056465	0.00024319
+AC[T>C]CC	0.00068759	0.00036087	0.00042838	0.00029225	0.00042021	0.00009412	0.00000001
+AC[T>C]CG	0.00000000	0.00005774	0.00000001	0.00000001	0.00032683	0.00000002	0.00032425
+AC[T>C]CT	0.00045088	0.00070732	0.00031154	0.00025050	0.00116724	0.00103519	0.00105382
+AC[T>C]GA	0.00252491	0.00047631	0.00035049	0.00008350	0.00056027	0.00084697	0.00040531
+AC[T>C]GC	0.00077776	0.00023095	0.00046733	0.00033400	0.00028013	0.00000002	0.00008107
+AC[T>C]GG	0.00099193	0.00023094	0.00035050	0.00020875	0.00009338	0.00103519	0.00008107
+AC[T>C]GT	0.00133009	0.00062069	0.00035049	0.00033400	0.00056027	0.00065876	0.00016213
+AC[T>C]TA	0.00021417	0.00021653	0.00031154	0.00054275	0.00289477	0.00028232	0.00016212
+AC[T>C]TC	0.00013526	0.00027427	0.00046733	0.00066801	0.00107387	0.00028232	0.00016212
+AC[T>C]TG	0.00051851	0.00043305	0.00062310	0.00012525	0.00149407	0.00047054	0.00024319
+AC[T>C]TT	0.00119482	0.00124142	0.00066204	0.00116900	0.00210104	0.00122340	0.00089169
+AC[T>G]AA	0.00011272	0.00028870	0.00019472	0.00016700	0.00056028	0.00056465	0.00048638
+AC[T>G]AC	0.00001127	0.00015879	0.00003895	0.00025050	0.00009338	0.00000002	0.00008107
+AC[T>G]AG	0.00002254	0.00025984	0.00000001	0.00008350	0.00000001	0.00000002	0.00000001
+AC[T>G]AT	0.00003382	0.00012992	0.00003895	0.00004175	0.00004669	0.00000002	0.00040533
+AC[T>G]CA	0.00032689	0.00025983	0.00003894	0.00054275	0.00070035	0.00037643	0.00000001
+AC[T>G]CC	0.00006763	0.00004330	0.00000001	0.00037575	0.00000001	0.00009412	0.00016213
+AC[T>G]CG	0.00004509	0.00000000	0.00003895	0.00004175	0.00004669	0.00000002	0.00000002
+AC[T>G]CT	0.00024798	0.00020209	0.00011683	0.00033400	0.00028014	0.00018823	0.00000001
+AC[T>G]GA	0.00033816	0.00015878	0.00058416	0.00033400	0.00051359	0.00047054	0.00081063
+AC[T>G]GC	0.00006763	0.00017322	0.00046733	0.00054275	0.00000001	0.00018823	0.00000001
+AC[T>G]GG	0.00018035	0.00012991	0.00007789	0.00045925	0.00018676	0.00065876	0.00008107
+AC[T>G]GT	0.00028180	0.00023096	0.00027260	0.00037575	0.00088710	0.00037643	0.00000001
+AC[T>G]TA	0.00063123	0.00043304	0.00089569	0.00100201	0.00723692	0.00065875	0.00113488
+AC[T>G]TC	0.00065377	0.00044748	0.00027259	0.00050100	0.00401532	0.00028232	0.00000001
+AC[T>G]TG	0.00039452	0.00050523	0.00050626	0.00104376	0.00340835	0.00000002	0.00008106
+AC[T>G]TT	0.00082285	0.00096715	0.00085675	0.00150301	0.00550939	0.00056464	0.00137807
+AG[C>A]AA	0.00098065	0.00178994	0.00276502	0.00146125	0.00158745	0.00470541	0.00324253
+AG[C>A]AC	0.00021416	0.00069288	0.00093465	0.00100201	0.00032683	0.00254093	0.00137808
+AG[C>A]AG	0.00063122	0.00124140	0.00120726	0.00121075	0.00107386	0.00432898	0.00283722
+AG[C>A]AT	0.00048469	0.00072175	0.00050627	0.00096025	0.00056027	0.00188217	0.00121595
+AG[C>A]CA	0.00060868	0.00092385	0.00073993	0.00075150	0.00060696	0.00047054	0.00032424
+AG[C>A]CC	0.00025925	0.00064958	0.00062310	0.00008349	0.00056028	0.00188217	0.00081063
+AG[C>A]CG	0.00006763	0.00001443	0.00000001	0.00008350	0.00000001	0.00028233	0.00000002
+AG[C>A]CT	0.00046215	0.00086611	0.00077887	0.00104375	0.00107386	0.00112930	0.00056744
+AG[C>A]GA	0.00003382	0.00028870	0.00015577	0.00008350	0.00004669	0.00056465	0.00064851
+AG[C>A]GC	0.00001127	0.00007218	0.00015578	0.00012525	0.00000001	0.00009412	0.00016214
+AG[C>A]GG	0.00012399	0.00015879	0.00027261	0.00000001	0.00000001	0.00018823	0.00000001
+AG[C>A]GT	0.00009018	0.00012992	0.00015578	0.00000001	0.00000001	0.00028233	0.00000001
+AG[C>A]TA	0.00102574	0.00099601	0.00093465	0.00058450	0.00065365	0.00159984	0.00097275
+AG[C>A]TC	0.00078903	0.00073619	0.00093465	0.00037575	0.00065365	0.00009411	0.00064850
+AG[C>A]TG	0.00191623	0.00088050	0.00089570	0.00050099	0.00158744	0.00216449	0.00113488
+AG[C>A]TT	0.00110465	0.00070730	0.00159670	0.00104375	0.00126062	0.00178806	0.00040531
+AG[C>G]AA	0.00010145	0.00056298	0.00050627	0.00087676	0.00051359	0.00009411	0.00081063
+AG[C>G]AC	0.00000000	0.00031758	0.00003895	0.00000001	0.00014007	0.00000002	0.00000001
+AG[C>G]AG	0.00013526	0.00020209	0.00038944	0.00045925	0.00051359	0.00018822	0.00000001
+AG[C>G]AT	0.00012399	0.00011548	0.00035050	0.00029225	0.00037352	0.00037643	0.00000001
+AG[C>G]CA	0.00012399	0.00064959	0.00089571	0.00012525	0.00032683	0.00000002	0.00000001
+AG[C>G]CC	0.00010145	0.00040418	0.00000000	0.00012525	0.00018676	0.00075287	0.00016213
+AG[C>G]CG	0.00001127	0.00001444	0.00000001	0.00000001	0.00032683	0.00000002	0.00000002
+AG[C>G]CT	0.00009017	0.00046193	0.00042838	0.00050100	0.00065366	0.00000002	0.00000001
+AG[C>G]GA	0.00002254	0.00014435	0.00000001	0.00033400	0.00014007	0.00028233	0.00000001
+AG[C>G]GC	0.00000000	0.00001444	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+AG[C>G]GG	0.00000000	0.00014435	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+AG[C>G]GT	0.00000000	0.00008661	0.00007789	0.00000001	0.00000001	0.00000002	0.00000002
+AG[C>G]TA	0.00025925	0.00070733	0.00050627	0.00070975	0.00037352	0.00000001	0.00040531
+AG[C>G]TC	0.00007890	0.00031758	0.00011683	0.00054275	0.00009338	0.00047054	0.00000001
+AG[C>G]TG	0.00009017	0.00063515	0.00054521	0.00108551	0.00032683	0.00065876	0.00016213
+AG[C>G]TT	0.00007890	0.00038975	0.00035049	0.00050100	0.00042021	0.00018821	0.00040532
+AG[C>T]AA	0.00184859	0.00118365	0.00171353	0.00100200	0.00102717	0.00263502	0.00218871
+AG[C>T]AC	0.00240092	0.00033196	0.00085677	0.00045925	0.00046689	0.00150573	0.00089169
+AG[C>T]AG	0.00267145	0.00085163	0.00147987	0.00083500	0.00088709	0.00131751	0.00081062
+AG[C>T]AT	0.00200640	0.00076503	0.00116832	0.00062625	0.00102716	0.00131751	0.00081063
+AG[C>T]CA	0.00550070	0.00118358	0.00097359	0.00125250	0.00102715	0.00207037	0.00097274
+AG[C>T]CC	0.00201768	0.00062067	0.00062310	0.00108550	0.00056027	0.00122340	0.00089169
+AG[C>T]CG	0.00104829	0.00010102	0.00003895	0.00020875	0.00014006	0.00018822	0.00048638
+AG[C>T]CT	0.00222057	0.00093825	0.00140198	0.00025049	0.00130730	0.00141162	0.00113488
+AG[C>T]GA	0.00458767	0.00096704	0.00253135	0.00212926	0.00242785	0.00451718	0.00372891
+AG[C>T]GC	0.00315614	0.00067839	0.00206403	0.00279727	0.00191426	0.00235270	0.00210764
+AG[C>T]GG	0.00334776	0.00064950	0.00171353	0.00171176	0.00224110	0.00395254	0.00259402
+AG[C>T]GT	0.00357320	0.00049072	0.00167459	0.00121075	0.00144737	0.00075285	0.00162126
+AG[C>T]TA	0.00090175	0.00030311	0.00054521	0.00062625	0.00060696	0.00169395	0.00064851
+AG[C>T]TC	0.00130754	0.00079391	0.00093465	0.00020874	0.00051358	0.00188217	0.00097276
+AG[C>T]TG	0.00235583	0.00076502	0.00198614	0.00070975	0.00084041	0.00122340	0.00113488
+AG[C>T]TT	0.00098066	0.00124141	0.00144092	0.00133600	0.00065365	0.00207038	0.00194552
+AG[T>A]AA	0.00007890	0.00047636	0.00027261	0.00045925	0.00014007	0.00028233	0.00000001
+AG[T>A]AC	0.00000000	0.00023097	0.00027261	0.00020875	0.00018676	0.00018823	0.00000001
+AG[T>A]AG	0.00003382	0.00030314	0.00007789	0.00033400	0.00028014	0.00009412	0.00000001
+AG[T>A]AT	0.00013526	0.00041862	0.00035049	0.00079326	0.00018676	0.00000002	0.00016212
+AG[T>A]CA	0.00015781	0.00031757	0.00077888	0.00054275	0.00028014	0.00028232	0.00000001
+AG[T>A]CC	0.00021417	0.00012991	0.00019472	0.00012525	0.00009338	0.00037643	0.00000001
+AG[T>A]CG	0.00005636	0.00004331	0.00003895	0.00000001	0.00000001	0.00000002	0.00000002
+AG[T>A]CT	0.00023671	0.00023096	0.00019472	0.00008350	0.00065366	0.00056465	0.00000001
+AG[T>A]GA	0.00018035	0.00051967	0.00050627	0.00041750	0.00042021	0.00037643	0.00024319
+AG[T>A]GC	0.00001127	0.00011548	0.00035050	0.00000001	0.00023345	0.00018823	0.00008107
+AG[T>A]GG	0.00005636	0.00030314	0.00046733	0.00000001	0.00028014	0.00000002	0.00000001
+AG[T>A]GT	0.00011272	0.00023096	0.00027261	0.00000001	0.00028014	0.00000002	0.00000001
+AG[T>A]TA	0.00033816	0.00051967	0.00038944	0.00054275	0.00070035	0.00047054	0.00000001
+AG[T>A]TC	0.00010145	0.00024540	0.00042838	0.00037575	0.00000001	0.00000001	0.00056744
+AG[T>A]TG	0.00032689	0.00036088	0.00015577	0.00037575	0.00065366	0.00009411	0.00048638
+AG[T>A]TT	0.00041706	0.00122700	0.00081782	0.00066800	0.00074703	0.00037643	0.00040531
+AG[T>C]AA	0.00103702	0.00090940	0.00093465	0.00054275	0.00144738	0.00094108	0.00097276
+AG[T>C]AC	0.00076649	0.00047635	0.00027260	0.00004175	0.00028013	0.00094108	0.00016213
+AG[T>C]AG	0.00102575	0.00062070	0.00035049	0.00075150	0.00074703	0.00065876	0.00048637
+AG[T>C]AT	0.00113846	0.00060626	0.00097360	0.00075150	0.00056027	0.00056464	0.00089169
+AG[T>C]CA	0.00071013	0.00036087	0.00038944	0.00041750	0.00065365	0.00037643	0.00016212
+AG[T>C]CC	0.00037197	0.00044748	0.00050627	0.00050100	0.00018676	0.00037643	0.00097276
+AG[T>C]CG	0.00003382	0.00005774	0.00000001	0.00008350	0.00000001	0.00000002	0.00000002
+AG[T>C]CT	0.00043960	0.00017321	0.00042838	0.00037575	0.00042021	0.00169395	0.00024319
+AG[T>C]GA	0.00158934	0.00057738	0.00007789	0.00079325	0.00042020	0.00084696	0.00202659
+AG[T>C]GC	0.00050724	0.00021651	0.00050627	0.00020875	0.00018676	0.00159985	0.00024320
+AG[T>C]GG	0.00083412	0.00021651	0.00015577	0.00025050	0.00014007	0.00018821	0.00056744
+AG[T>C]GT	0.00100320	0.00059182	0.00073993	0.00045925	0.00102717	0.00056464	0.00137808
+AG[T>C]TA	0.00081158	0.00025982	0.00019472	0.00087676	0.00028013	0.00056465	0.00048638
+AG[T>C]TC	0.00036070	0.00027426	0.00046733	0.00041750	0.00032683	0.00056465	0.00081064
+AG[T>C]TG	0.00074395	0.00054852	0.00031155	0.00079325	0.00084041	0.00188217	0.00048638
+AG[T>C]TT	0.00081158	0.00076506	0.00089571	0.00171176	0.00112055	0.00103519	0.00016211
+AG[T>G]AA	0.00007890	0.00040419	0.00019472	0.00041750	0.00018676	0.00037643	0.00056744
+AG[T>G]AC	0.00006763	0.00010105	0.00000001	0.00004175	0.00000001	0.00000002	0.00000002
+AG[T>G]AG	0.00003382	0.00014435	0.00000001	0.00012525	0.00009338	0.00000002	0.00024319
+AG[T>G]AT	0.00000000	0.00012992	0.00007789	0.00008350	0.00028014	0.00028233	0.00000001
+AG[T>G]CA	0.00010145	0.00020209	0.00000001	0.00004175	0.00028014	0.00000002	0.00000001
+AG[T>G]CC	0.00001127	0.00008661	0.00003895	0.00000001	0.00000001	0.00000002	0.00016213
+AG[T>G]CG	0.00000000	0.00001444	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+AG[T>G]CT	0.00003382	0.00011548	0.00027261	0.00008350	0.00028014	0.00000002	0.00000001
+AG[T>G]GA	0.00004509	0.00050524	0.00050627	0.00016700	0.00028014	0.00056465	0.00000001
+AG[T>G]GC	0.00000000	0.00027427	0.00003895	0.00000001	0.00004669	0.00000002	0.00000001
+AG[T>G]GG	0.00001127	0.00020210	0.00000001	0.00000001	0.00009338	0.00000002	0.00000002
+AG[T>G]GT	0.00005636	0.00047637	0.00023366	0.00041750	0.00018676	0.00000002	0.00000001
+AG[T>G]TA	0.00020289	0.00043306	0.00019471	0.00045925	0.00107387	0.00037643	0.00040531
+AG[T>G]TC	0.00010145	0.00021653	0.00015577	0.00033400	0.00070035	0.00037644	0.00016212
+AG[T>G]TG	0.00025925	0.00020209	0.00015577	0.00012525	0.00070035	0.00000002	0.00008107
+AG[T>G]TT	0.00052978	0.00034643	0.00081782	0.00045925	0.00130731	0.00065876	0.00016212
+AT[C>A]AA	0.00050723	0.00180440	0.00233663	0.00217101	0.00172752	0.00395256	0.00089168
+AT[C>A]AC	0.00038324	0.00121256	0.00097359	0.00033399	0.00079372	0.00056466	0.00056744
+AT[C>A]AG	0.00036070	0.00125587	0.00190825	0.00096025	0.00042021	0.00065875	0.00105381
+AT[C>A]AT	0.00051851	0.00144352	0.00280396	0.00158650	0.00242787	0.00207038	0.00170232
+AT[C>A]CA	0.00111592	0.00145794	0.00116831	0.00146125	0.00126062	0.00254092	0.00162126
+AT[C>A]CC	0.00048469	0.00108263	0.00101254	0.00012524	0.00084041	0.00301148	0.00048637
+AT[C>A]CG	0.00003382	0.00014435	0.00007789	0.00020875	0.00009338	0.00000002	0.00032425
+AT[C>A]CT	0.00067631	0.00216529	0.00159669	0.00100199	0.00102717	0.00178805	0.00145913
+AT[C>A]GA	0.00009017	0.00015879	0.00070099	0.00037575	0.00037352	0.00028233	0.00000001
+AT[C>A]GC	0.00007890	0.00023096	0.00011683	0.00000001	0.00028014	0.00018822	0.00000001
+AT[C>A]GG	0.00013526	0.00004330	0.00046733	0.00008350	0.00004669	0.00065876	0.00032425
+AT[C>A]GT	0.00012399	0.00020209	0.00003895	0.00029225	0.00000001	0.00000002	0.00008107
+AT[C>A]TA	0.00180351	0.00138575	0.00292080	0.00125250	0.00088710	0.00188216	0.00113487
+AT[C>A]TC	0.00142026	0.00118365	0.00183036	0.00141950	0.00205434	0.00385844	0.00194551
+AT[C>A]TG	0.00218675	0.00183324	0.00128514	0.00179525	0.00247455	0.00282324	0.00186445
+AT[C>A]TT	0.00225438	0.00298805	0.00494588	0.00300600	0.00247455	0.00357609	0.00437741
+AT[C>G]AA	0.00069885	0.00944074	0.00366068	0.00738975	0.00121393	0.00235269	0.00291821
+AT[C>G]AC	0.00016908	0.00153015	0.00073993	0.00125250	0.00004669	0.00018822	0.00089169
+AT[C>G]AG	0.00031561	0.00420069	0.00202507	0.00425851	0.00028014	0.00028231	0.00154017
+AT[C>G]AT	0.00037197	0.00332013	0.00167458	0.00263025	0.00004669	0.00065874	0.00194550
+AT[C>G]CA	0.00011272	0.00255506	0.00175247	0.00258851	0.00042021	0.00037642	0.00154019
+AT[C>G]CC	0.00005636	0.00095274	0.00015577	0.00033399	0.00004669	0.00056465	0.00032425
+AT[C>G]CG	0.00001127	0.00008661	0.00011683	0.00016700	0.00000001	0.00000002	0.00000001
+AT[C>G]CT	0.00023671	0.00206426	0.00081781	0.00125250	0.00070035	0.00047054	0.00081062
+AT[C>G]GA	0.00007890	0.00034645	0.00019472	0.00012525	0.00014007	0.00000002	0.00016213
+AT[C>G]GC	0.00000000	0.00024540	0.00003895	0.00016700	0.00004669	0.00000002	0.00000001
+AT[C>G]GG	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+AT[C>G]GT	0.00000000	0.00025984	0.00023366	0.00041750	0.00000001	0.00000002	0.00008107
+AT[C>G]TA	0.00048469	0.00584632	0.00416698	0.00425850	0.00126062	0.00094106	0.00316143
+AT[C>G]TC	0.00042833	0.00420068	0.00136301	0.00375751	0.00060697	0.00141162	0.00162124
+AT[C>G]TG	0.00055232	0.00446052	0.00116829	0.00217098	0.00098048	0.00094106	0.00316145
+AT[C>G]TT	0.00065377	0.00762187	0.00358281	0.00488474	0.00112055	0.00141160	0.00389100
+AT[C>T]AA	0.00100320	0.00382534	0.00292078	0.00288075	0.00149407	0.00178802	0.00559337
+AT[C>T]AC	0.00086794	0.00308916	0.00214190	0.00217100	0.00144738	0.00028231	0.00235082
+AT[C>T]AG	0.00122864	0.00472034	0.00393333	0.00484302	0.00088710	0.00216447	0.00316144
+AT[C>T]AT	0.00143153	0.00498016	0.00479009	0.00459251	0.00224110	0.00272912	0.00413420
+AT[C>T]CA	0.00127373	0.00197762	0.00210297	0.00150300	0.00121393	0.00197627	0.00097274
+AT[C>T]CC	0.00076649	0.00189102	0.00136303	0.00075149	0.00154076	0.00065875	0.00137807
+AT[C>T]CG	0.00032689	0.00033201	0.00031155	0.00091851	0.00018676	0.00000002	0.00000001
+AT[C>T]CT	0.00093557	0.00243956	0.00183035	0.00121074	0.00135400	0.00103519	0.00081062
+AT[C>T]GA	0.00121737	0.00063512	0.00144093	0.00112726	0.00070034	0.00103518	0.00178339
+AT[C>T]GC	0.00178096	0.00118365	0.00202508	0.00158651	0.00163413	0.00225858	0.00316147
+AT[C>T]GG	0.00063123	0.00090940	0.00073993	0.00079325	0.00093379	0.00094107	0.00283722
+AT[C>T]GT	0.00144281	0.00111149	0.00233664	0.00100200	0.00056027	0.00112929	0.00129700
+AT[C>T]TA	0.00036070	0.00135691	0.00171353	0.00141950	0.00074703	0.00065874	0.00194552
+AT[C>T]TC	0.00049596	0.00271383	0.00206402	0.00141949	0.00196097	0.00254091	0.00316147
+AT[C>T]TG	0.00063123	0.00269940	0.00163563	0.00217100	0.00144738	0.00159984	0.00145912
+AT[C>T]TT	0.00082285	0.00330568	0.00385544	0.00196224	0.00177421	0.00207037	0.00194550
+AT[T>A]AA	0.00010145	0.00049080	0.00058416	0.00037575	0.00084042	0.00000002	0.00024319
+AT[T>A]AC	0.00000000	0.00027427	0.00050627	0.00020875	0.00046690	0.00000001	0.00072957
+AT[T>A]AG	0.00004509	0.00040419	0.00042838	0.00033400	0.00070035	0.00000001	0.00097276
+AT[T>A]AT	0.00021417	0.00059184	0.00089571	0.00029225	0.00098048	0.00047054	0.00089170
+AT[T>A]CA	0.00016908	0.00037532	0.00031155	0.00062625	0.00051359	0.00018821	0.00040532
+AT[T>A]CC	0.00013526	0.00027427	0.00011683	0.00004175	0.00023345	0.00000002	0.00040532
+AT[T>A]CG	0.00002254	0.00000000	0.00000001	0.00000001	0.00009338	0.00000002	0.00000002
+AT[T>A]CT	0.00022544	0.00067846	0.00035049	0.00012524	0.00065365	0.00056465	0.00016212
+AT[T>A]GA	0.00005636	0.00031758	0.00023366	0.00033400	0.00056028	0.00028234	0.00000001
+AT[T>A]GC	0.00009018	0.00034644	0.00019472	0.00045925	0.00000001	0.00018822	0.00032425
+AT[T>A]GG	0.00000000	0.00017322	0.00000001	0.00008350	0.00023345	0.00028233	0.00000002
+AT[T>A]GT	0.00001127	0.00033201	0.00019472	0.00020875	0.00051359	0.00000002	0.00000001
+AT[T>A]TA	0.00021417	0.00060628	0.00046733	0.00070975	0.00018676	0.00056465	0.00032425
+AT[T>A]TC	0.00013526	0.00031757	0.00019472	0.00004175	0.00042021	0.00065876	0.00048638
+AT[T>A]TG	0.00018035	0.00056297	0.00050627	0.00029225	0.00023345	0.00131752	0.00040531
+AT[T>A]TT	0.00172460	0.00187656	0.00198613	0.00179525	0.00242786	0.00112929	0.00194550
+AT[T>C]AA	0.00119482	0.00053408	0.00035049	0.00033400	0.00079372	0.00037643	0.00008107
+AT[T>C]AC	0.00102575	0.00040417	0.00007788	0.00041750	0.00074703	0.00065875	0.00097276
+AT[T>C]AG	0.00072140	0.00049079	0.00062310	0.00029225	0.00093379	0.00037643	0.00032425
+AT[T>C]AT	0.00131882	0.00077948	0.00085676	0.00150301	0.00196097	0.00065875	0.00040531
+AT[T>C]CA	0.00080031	0.00023094	0.00089571	0.00037575	0.00018675	0.00122341	0.00032425
+AT[T>C]CC	0.00055232	0.00021651	0.00050627	0.00016700	0.00051358	0.00056464	0.00089170
+AT[T>C]CG	0.00003382	0.00005774	0.00007789	0.00008350	0.00000001	0.00028234	0.00000002
+AT[T>C]CT	0.00050724	0.00060627	0.00062310	0.00058450	0.00088710	0.00075286	0.00064850
+AT[T>C]GA	0.00189368	0.00020205	0.00120727	0.00029225	0.00056027	0.00047053	0.00040531
+AT[T>C]GC	0.00104829	0.00020207	0.00089571	0.00004175	0.00009338	0.00075286	0.00024320
+AT[T>C]GG	0.00110465	0.00023094	0.00062310	0.00012525	0.00018675	0.00056465	0.00000001
+AT[T>C]GT	0.00081158	0.00018764	0.00058416	0.00041750	0.00107386	0.00009411	0.00105383
+AT[T>C]TA	0.00075522	0.00012990	0.00015577	0.00079326	0.00042020	0.00084698	0.00016213
+AT[T>C]TC	0.00061996	0.00031756	0.00042838	0.00033400	0.00032683	0.00094108	0.00024319
+AT[T>C]TG	0.00095811	0.00034643	0.00038944	0.00083501	0.00046689	0.00009411	0.00129701
+AT[T>C]TT	0.00067631	0.00056296	0.00035049	0.00129426	0.00102717	0.00197628	0.00105382
+AT[T>G]AA	0.00001127	0.00057741	0.00054521	0.00121076	0.00210104	0.00094108	0.00097276
+AT[T>G]AC	0.00000000	0.00018766	0.00015577	0.00012525	0.00037352	0.00000002	0.00008107
+AT[T>G]AG	0.00009018	0.00018766	0.00003895	0.00029225	0.00014007	0.00037644	0.00000001
+AT[T>G]AT	0.00003382	0.00059185	0.00058416	0.00045925	0.00098048	0.00000001	0.00048638
+AT[T>G]CA	0.00009017	0.00046193	0.00035049	0.00050100	0.00056028	0.00018821	0.00056744
+AT[T>G]CC	0.00002254	0.00014435	0.00000001	0.00008350	0.00023345	0.00000002	0.00000002
+AT[T>G]CG	0.00000000	0.00000000	0.00000001	0.00004175	0.00000001	0.00000002	0.00000002
+AT[T>G]CT	0.00019162	0.00014435	0.00031155	0.00070976	0.00028014	0.00075287	0.00008107
+AT[T>G]GA	0.00018035	0.00014435	0.00046733	0.00050100	0.00088711	0.00028232	0.00048638
+AT[T>G]GC	0.00000000	0.00011548	0.00038944	0.00012525	0.00051359	0.00000002	0.00016213
+AT[T>G]GG	0.00003382	0.00031758	0.00003895	0.00033400	0.00018676	0.00028233	0.00008107
+AT[T>G]GT	0.00006763	0.00057741	0.00023366	0.00025050	0.00018676	0.00000002	0.00048638
+AT[T>G]TA	0.00038324	0.00083723	0.00077887	0.00125251	0.00266132	0.00159984	0.00081063
+AT[T>G]TC	0.00022544	0.00054854	0.00031154	0.00096026	0.00336166	0.00018821	0.00121595
+AT[T>G]TG	0.00031561	0.00037531	0.00007788	0.00066801	0.00149407	0.00047055	0.00040531
+AT[T>G]TT	0.00075522	0.00134247	0.00140197	0.00150301	0.00443553	0.00047054	0.00048637
+CA[C>A]AA	0.00047342	0.00128472	0.00093465	0.00121075	0.00098048	0.00188216	0.00194552
+CA[C>A]AC	0.00010145	0.00043305	0.00054521	0.00012525	0.00051359	0.00103520	0.00008107
+CA[C>A]AG	0.00024798	0.00072176	0.00093465	0.00041750	0.00065366	0.00056464	0.00121595
+CA[C>A]AT	0.00021417	0.00047636	0.00066205	0.00050100	0.00042021	0.00112930	0.00089170
+CA[C>A]CA	0.00037197	0.00088055	0.00190826	0.00045925	0.00102717	0.00056464	0.00113488
+CA[C>A]CC	0.00023671	0.00046192	0.00093465	0.00041750	0.00116724	0.00197628	0.00097276
+CA[C>A]CG	0.00010145	0.00002887	0.00011683	0.00004175	0.00046690	0.00000002	0.00000002
+CA[C>A]CT	0.00051851	0.00076506	0.00116832	0.00045925	0.00121393	0.00065876	0.00048637
+CA[C>A]GA	0.00001127	0.00014435	0.00007789	0.00004175	0.00004669	0.00000002	0.00008107
+CA[C>A]GC	0.00002254	0.00021653	0.00000001	0.00000001	0.00000001	0.00018823	0.00000001
+CA[C>A]GG	0.00013526	0.00008661	0.00011683	0.00008350	0.00000001	0.00018823	0.00000001
+CA[C>A]GT	0.00002254	0.00015879	0.00011683	0.00016700	0.00023345	0.00000002	0.00032425
+CA[C>A]TA	0.00045088	0.00033200	0.00023366	0.00025050	0.00014007	0.00009411	0.00056744
+CA[C>A]TC	0.00049596	0.00041861	0.00050627	0.00029225	0.00051359	0.00028232	0.00040531
+CA[C>A]TG	0.00077776	0.00119812	0.00089571	0.00041749	0.00051358	0.00037643	0.00081063
+CA[C>A]TT	0.00082285	0.00085167	0.00070099	0.00091850	0.00079372	0.00018821	0.00016212
+CA[C>G]AA	0.00009017	0.00044749	0.00035049	0.00096026	0.00060697	0.00000002	0.00032425
+CA[C>G]AC	0.00016908	0.00033201	0.00015577	0.00020875	0.00000001	0.00075287	0.00040532
+CA[C>G]AG	0.00055232	0.00063514	0.00031155	0.00066800	0.00023345	0.00037643	0.00064850
+CA[C>G]AT	0.00006763	0.00037532	0.00046733	0.00045925	0.00028014	0.00018822	0.00040531
+CA[C>G]CA	0.00012399	0.00093830	0.00023366	0.00012525	0.00098049	0.00037643	0.00048638
+CA[C>G]CC	0.00013526	0.00036088	0.00015577	0.00008350	0.00009338	0.00037643	0.00008107
+CA[C>G]CG	0.00004509	0.00004331	0.00000001	0.00000001	0.00018676	0.00000002	0.00000002
+CA[C>G]CT	0.00009017	0.00038975	0.00073994	0.00012525	0.00051359	0.00065876	0.00072957
+CA[C>G]GA	0.00000000	0.00015879	0.00015577	0.00012525	0.00018676	0.00037643	0.00032425
+CA[C>G]GC	0.00000000	0.00015879	0.00035050	0.00000001	0.00018676	0.00000002	0.00000001
+CA[C>G]GG	0.00003382	0.00021653	0.00003895	0.00020875	0.00004669	0.00000002	0.00024319
+CA[C>G]GT	0.00005636	0.00036088	0.00023366	0.00020875	0.00009338	0.00000002	0.00040532
+CA[C>G]TA	0.00006763	0.00031758	0.00038944	0.00058450	0.00107386	0.00000002	0.00000001
+CA[C>G]TC	0.00021417	0.00060628	0.00050627	0.00045925	0.00042021	0.00009411	0.00072957
+CA[C>G]TG	0.00025925	0.00053410	0.00062310	0.00096026	0.00065366	0.00084697	0.00105382
+CA[C>G]TT	0.00029307	0.00038975	0.00046733	0.00125251	0.00046690	0.00000001	0.00064850
+CA[C>T]AA	0.00206276	0.00053406	0.00077888	0.00075150	0.00102716	0.00122340	0.00097276
+CA[C>T]AC	0.00236711	0.00034639	0.00062310	0.00054275	0.00149406	0.00178805	0.00081063
+CA[C>T]AG	0.00365211	0.00072168	0.00105148	0.00150301	0.00107385	0.00244681	0.00056744
+CA[C>T]AT	0.00455386	0.00129909	0.00124620	0.00100199	0.00191426	0.00065874	0.00121594
+CA[C>T]CA	0.00176969	0.00072172	0.00097360	0.00079325	0.00107386	0.00131751	0.00154020
+CA[C>T]CC	0.00120610	0.00046190	0.00144093	0.00087675	0.00098048	0.00103518	0.00105382
+CA[C>T]CG	0.00040579	0.00017322	0.00007789	0.00029225	0.00056028	0.00000002	0.00024319
+CA[C>T]CT	0.00119482	0.00051964	0.00128515	0.00087675	0.00112055	0.00112930	0.00048637
+CA[C>T]GA	0.00307723	0.00082273	0.00260924	0.00225452	0.00303482	0.00254090	0.00372891
+CA[C>T]GC	0.00840886	0.00216508	0.00408910	0.00505178	0.00462225	0.00649343	0.00713357
+CA[C>T]GG	0.00317868	0.00153005	0.00202507	0.00329827	0.00471566	0.00376431	0.00470167
+CA[C>T]GT	0.00486947	0.00073608	0.00179142	0.00283902	0.00200764	0.00319967	0.00194551
+CA[C>T]TA	0.00116101	0.00014433	0.00023366	0.00058450	0.00037351	0.00056465	0.00048638
+CA[C>T]TC	0.00100320	0.00050521	0.00046732	0.00075150	0.00093379	0.00084697	0.00137808
+CA[C>T]TG	0.00298706	0.00075057	0.00073993	0.00066800	0.00046688	0.00112928	0.00259403
+CA[C>T]TT	0.00083412	0.00127029	0.00136303	0.00196226	0.00130731	0.00094107	0.00194551
+CA[T>A]AA	0.00016908	0.00076507	0.00019471	0.00050100	0.00093380	0.00047054	0.00016212
+CA[T>A]AC	0.00016908	0.00028870	0.00019472	0.00012525	0.00023345	0.00009412	0.00016212
+CA[T>A]AG	0.00010145	0.00043306	0.00019472	0.00016700	0.00018676	0.00018822	0.00048638
+CA[T>A]AT	0.00011272	0.00027427	0.00035050	0.00058450	0.00014007	0.00009411	0.00072957
+CA[T>A]CA	0.00025925	0.00041862	0.00027261	0.00029225	0.00014007	0.00018822	0.00024319
+CA[T>A]CC	0.00025925	0.00014435	0.00019472	0.00045925	0.00004669	0.00009412	0.00000001
+CA[T>A]CG	0.00001127	0.00001444	0.00000001	0.00004175	0.00000001	0.00000002	0.00008107
+CA[T>A]CT	0.00012399	0.00047636	0.00042838	0.00025050	0.00037352	0.00009411	0.00048638
+CA[T>A]GA	0.00004509	0.00075064	0.00073993	0.00045925	0.00046690	0.00018821	0.00081063
+CA[T>A]GC	0.00009018	0.00027427	0.00003895	0.00012525	0.00028014	0.00009412	0.00000001
+CA[T>A]GG	0.00006763	0.00031758	0.00003894	0.00058451	0.00037352	0.00047054	0.00008107
+CA[T>A]GT	0.00007890	0.00047637	0.00007788	0.00029225	0.00004669	0.00037644	0.00024319
+CA[T>A]TA	0.00039452	0.00050523	0.00066205	0.00041750	0.00056028	0.00047055	0.00056744
+CA[T>A]TC	0.00020289	0.00005774	0.00007789	0.00020875	0.00000001	0.00000002	0.00000001
+CA[T>A]TG	0.00011272	0.00040419	0.00007788	0.00008350	0.00051359	0.00037643	0.00016213
+CA[T>A]TT	0.00067632	0.00125586	0.00042838	0.00050099	0.00028013	0.00028232	0.00081063
+CA[T>C]AA	0.00133009	0.00040416	0.00015577	0.00033400	0.00065365	0.00009410	0.00137808
+CA[T>C]AC	0.00083412	0.00036086	0.00042838	0.00050100	0.00037351	0.00065875	0.00097276
+CA[T>C]AG	0.00110465	0.00064956	0.00109043	0.00075150	0.00065365	0.00112929	0.00097276
+CA[T>C]AT	0.00187114	0.00090939	0.00093465	0.00062625	0.00093379	0.00018821	0.00129701
+CA[T>C]CA	0.00101447	0.00027425	0.00031155	0.00033400	0.00037351	0.00028232	0.00097276
+CA[T>C]CC	0.00086794	0.00023095	0.00023367	0.00029225	0.00032682	0.00037643	0.00040532
+CA[T>C]CG	0.00011272	0.00000000	0.00011683	0.00000001	0.00000001	0.00000002	0.00000002
+CA[T>C]CT	0.00066504	0.00067845	0.00023366	0.00075150	0.00088710	0.00037643	0.00024318
+CA[T>C]GA	0.00436224	0.00043297	0.00046732	0.00108550	0.00070033	0.00018821	0.00097275
+CA[T>C]GC	0.00123991	0.00020207	0.00023366	0.00025050	0.00032682	0.00018821	0.00032425
+CA[T>C]GG	0.00229947	0.00064954	0.00058415	0.00029224	0.00060696	0.00056464	0.00064850
+CA[T>C]GT	0.00157807	0.00083721	0.00085676	0.00070975	0.00042020	0.00065875	0.00129701
+CA[T>C]TA	0.00054105	0.00056296	0.00054521	0.00083500	0.00070034	0.00094108	0.00048637
+CA[T>C]TC	0.00055232	0.00057740	0.00011683	0.00033400	0.00121393	0.00037643	0.00097276
+CA[T>C]TG	0.00069886	0.00075062	0.00058415	0.00125251	0.00098048	0.00075286	0.00105382
+CA[T>C]TT	0.00065377	0.00106819	0.00147987	0.00154476	0.00144738	0.00122339	0.00267509
+CA[T>G]AA	0.00007890	0.00017322	0.00038944	0.00025050	0.00135400	0.00028232	0.00024320
+CA[T>G]AC	0.00000000	0.00008661	0.00015578	0.00004175	0.00000001	0.00000002	0.00040532
+CA[T>G]AG	0.00003382	0.00007218	0.00019472	0.00029225	0.00028014	0.00037644	0.00000001
+CA[T>G]AT	0.00004509	0.00008661	0.00015578	0.00025050	0.00009338	0.00000002	0.00000001
+CA[T>G]CA	0.00012399	0.00008661	0.00015578	0.00033400	0.00000001	0.00028233	0.00000001
+CA[T>G]CC	0.00007890	0.00005774	0.00000001	0.00000001	0.00000001	0.00000002	0.00008107
+CA[T>G]CG	0.00011272	0.00000000	0.00000001	0.00012526	0.00000001	0.00000002	0.00000002
+CA[T>G]CT	0.00007890	0.00018766	0.00015577	0.00008350	0.00042021	0.00000002	0.00000001
+CA[T>G]GA	0.00014653	0.00025983	0.00011683	0.00041750	0.00000001	0.00000001	0.00040533
+CA[T>G]GC	0.00009018	0.00023097	0.00007789	0.00004175	0.00032683	0.00000002	0.00000001
+CA[T>G]GG	0.00003382	0.00017322	0.00031155	0.00000001	0.00009338	0.00000002	0.00032425
+CA[T>G]GT	0.00001127	0.00020209	0.00035050	0.00020875	0.00000001	0.00018822	0.00048638
+CA[T>G]TA	0.00023671	0.00015879	0.00019472	0.00000001	0.00032683	0.00000002	0.00008107
+CA[T>G]TC	0.00030434	0.00012991	0.00003895	0.00000001	0.00037352	0.00000002	0.00024320
+CA[T>G]TG	0.00004509	0.00011548	0.00011684	0.00033400	0.00014007	0.00009412	0.00000001
+CA[T>G]TT	0.00040579	0.00037531	0.00035049	0.00058450	0.00093379	0.00028232	0.00016212
+CC[C>A]AA	0.00155552	0.00151566	0.00237558	0.00091849	0.00060696	0.00376434	0.00064849
+CC[C>A]AC	0.00105956	0.00069286	0.00081782	0.00050100	0.00023344	0.00216449	0.00064850
+CC[C>A]AG	0.00135263	0.00180437	0.00214191	0.00179525	0.00140069	0.00611706	0.00162125
+CC[C>A]AT	0.00151044	0.00083722	0.00147987	0.00096025	0.00065365	0.00037643	0.00056743
+CC[C>A]CA	0.00302088	0.00109703	0.00097359	0.00066799	0.00070033	0.00047053	0.00024318
+CC[C>A]CC	0.00078903	0.00049079	0.00085677	0.00050100	0.00018676	0.00037643	0.00040531
+CC[C>A]CG	0.00020289	0.00012991	0.00000001	0.00008350	0.00023345	0.00000002	0.00016213
+CC[C>A]CT	0.00109338	0.00079392	0.00116832	0.00079325	0.00042020	0.00094108	0.00032424
+CC[C>A]GA	0.00043960	0.00041861	0.00038944	0.00016700	0.00000001	0.00103519	0.00008107
+CC[C>A]GC	0.00054105	0.00010104	0.00027261	0.00000001	0.00000001	0.00000002	0.00000001
+CC[C>A]GG	0.00065377	0.00030313	0.00011683	0.00025050	0.00018676	0.00000002	0.00000001
+CC[C>A]GT	0.00043961	0.00007217	0.00000001	0.00000001	0.00023345	0.00000002	0.00000001
+CC[C>A]TA	0.00272781	0.00109703	0.00054521	0.00033399	0.00084040	0.00094108	0.00024319
+CC[C>A]TC	0.00532035	0.00103924	0.00058415	0.00066799	0.00070032	0.00122340	0.00008105
+CC[C>A]TG	0.00624465	0.00129906	0.00105148	0.00125249	0.00065362	0.00094107	0.00064849
+CC[C>A]TT	0.00472294	0.00098151	0.00109042	0.00041749	0.00177419	0.00103518	0.00089168
+CC[C>G]AA	0.00013526	0.00088055	0.00070099	0.00158651	0.00037352	0.00028232	0.00064850
+CC[C>G]AC	0.00002254	0.00018766	0.00003895	0.00029225	0.00004669	0.00000002	0.00000001
+CC[C>G]AG	0.00015781	0.00044749	0.00042838	0.00108551	0.00000001	0.00065876	0.00000001
+CC[C>G]AT	0.00002254	0.00027427	0.00050627	0.00008350	0.00004669	0.00056465	0.00016212
+CC[C>G]CA	0.00003381	0.00064958	0.00066205	0.00025050	0.00018676	0.00131752	0.00072957
+CC[C>G]CC	0.00000000	0.00038975	0.00015577	0.00008350	0.00018676	0.00047054	0.00072957
+CC[C>G]CG	0.00000000	0.00010105	0.00007789	0.00000001	0.00000001	0.00000002	0.00000002
+CC[C>G]CT	0.00001127	0.00025983	0.00038944	0.00025050	0.00000001	0.00009411	0.00032426
+CC[C>G]GA	0.00000000	0.00014435	0.00023366	0.00008350	0.00004669	0.00037643	0.00008107
+CC[C>G]GC	0.00003382	0.00031758	0.00019472	0.00004175	0.00000001	0.00000002	0.00008107
+CC[C>G]GG	0.00010145	0.00034645	0.00042838	0.00000000	0.00000001	0.00000002	0.00000001
+CC[C>G]GT	0.00000000	0.00014435	0.00007789	0.00033400	0.00018676	0.00000002	0.00000001
+CC[C>G]TA	0.00007890	0.00060628	0.00062310	0.00066800	0.00018676	0.00037643	0.00048638
+CC[C>G]TC	0.00002254	0.00075064	0.00027260	0.00012524	0.00014007	0.00000002	0.00048638
+CC[C>G]TG	0.00004509	0.00050523	0.00046732	0.00054275	0.00060697	0.00065876	0.00048638
+CC[C>G]TT	0.00005636	0.00053411	0.00023366	0.00070975	0.00135401	0.00009411	0.00081063
+CC[C>T]AA	0.00065377	0.00064958	0.00085677	0.00033400	0.00051359	0.00131752	0.00032425
+CC[C>T]AC	0.00045088	0.00073619	0.00081782	0.00116901	0.00088710	0.00131752	0.00048637
+CC[C>T]AG	0.00091302	0.00119812	0.00237558	0.00154476	0.00196096	0.00065875	0.00105381
+CC[C>T]AT	0.00083412	0.00047635	0.00093465	0.00058450	0.00074703	0.00075286	0.00089169
+CC[C>T]CA	0.00116101	0.00070730	0.00066204	0.00066800	0.00112055	0.00141162	0.00154020
+CC[C>T]CC	0.00037197	0.00037531	0.00097360	0.00041750	0.00088710	0.00047055	0.00032425
+CC[C>T]CG	0.00013526	0.00030314	0.00011683	0.00000001	0.00023345	0.00009411	0.00040532
+CC[C>T]CT	0.00096938	0.00062069	0.00093465	0.00041750	0.00116724	0.00225861	0.00016212
+CC[C>T]GA	0.00229947	0.00124138	0.00089570	0.00200401	0.00186758	0.00254092	0.00210764
+CC[C>T]GC	0.00452004	0.00079383	0.00303763	0.00204576	0.00154074	0.00367021	0.00226976
+CC[C>T]GG	0.00503855	0.00181873	0.00377756	0.00400802	0.00420206	0.00291733	0.00389103
+CC[C>T]GT	0.00229947	0.00118364	0.00112937	0.00196226	0.00135399	0.00141160	0.00308041
+CC[C>T]TA	0.00042833	0.00046192	0.00077888	0.00016700	0.00032683	0.00084697	0.00032425
+CC[C>T]TC	0.00058614	0.00083724	0.00031154	0.00037575	0.00088710	0.00037643	0.00089169
+CC[C>T]TG	0.00073267	0.00066401	0.00066204	0.00020874	0.00121393	0.00131751	0.00081063
+CC[C>T]TT	0.00138645	0.00077948	0.00257031	0.00070975	0.00107386	0.00037642	0.00129700
+CC[T>A]AA	0.00011272	0.00027427	0.00000001	0.00087676	0.00018676	0.00037643	0.00008107
+CC[T>A]AC	0.00006763	0.00015879	0.00035050	0.00041750	0.00023345	0.00000002	0.00000001
+CC[T>A]AG	0.00003382	0.00033201	0.00007789	0.00012525	0.00004669	0.00056465	0.00024319
+CC[T>A]AT	0.00005636	0.00033201	0.00023366	0.00029225	0.00018676	0.00000002	0.00008107
+CC[T>A]CA	0.00029307	0.00053410	0.00070099	0.00083500	0.00023345	0.00018822	0.00089169
+CC[T>A]CC	0.00022544	0.00089499	0.00031155	0.00033400	0.00028014	0.00056465	0.00032425
+CC[T>A]CG	0.00007890	0.00010105	0.00000001	0.00025051	0.00004669	0.00000002	0.00000002
+CC[T>A]CT	0.00016908	0.00063515	0.00097360	0.00066800	0.00046690	0.00028233	0.00048638
+CC[T>A]GA	0.00010145	0.00017322	0.00058416	0.00008350	0.00056028	0.00000002	0.00000001
+CC[T>A]GC	0.00014653	0.00036088	0.00050627	0.00045925	0.00028014	0.00028233	0.00000001
+CC[T>A]GG	0.00014653	0.00033201	0.00015577	0.00029225	0.00023345	0.00018822	0.00000001
+CC[T>A]GT	0.00020289	0.00053410	0.00046733	0.00000000	0.00023345	0.00028232	0.00008107
+CC[T>A]TA	0.00006763	0.00049080	0.00077888	0.00020875	0.00018676	0.00000002	0.00000001
+CC[T>A]TC	0.00010145	0.00038975	0.00042838	0.00025050	0.00032683	0.00000002	0.00040532
+CC[T>A]TG	0.00005636	0.00012992	0.00035050	0.00029225	0.00046690	0.00047054	0.00000001
+CC[T>A]TT	0.00036070	0.00076507	0.00066204	0.00062625	0.00070035	0.00000001	0.00081063
+CC[T>C]AA	0.00129627	0.00031755	0.00007789	0.00096026	0.00070034	0.00037643	0.00056744
+CC[T>C]AC	0.00078904	0.00017321	0.00035050	0.00045925	0.00014007	0.00009411	0.00040532
+CC[T>C]AG	0.00087921	0.00041860	0.00019472	0.00012525	0.00004669	0.00065876	0.00024319
+CC[T>C]AT	0.00116101	0.00040417	0.00011683	0.00045925	0.00070034	0.00018822	0.00024319
+CC[T>C]CA	0.00090175	0.00043304	0.00015577	0.00029225	0.00032682	0.00018821	0.00032425
+CC[T>C]CC	0.00091303	0.00031756	0.00035049	0.00045925	0.00065365	0.00009412	0.00000001
+CC[T>C]CG	0.00020289	0.00014435	0.00000001	0.00020875	0.00000001	0.00000002	0.00000001
+CC[T>C]CT	0.00056360	0.00036087	0.00046732	0.00100201	0.00121393	0.00065875	0.00129701
+CC[T>C]GA	0.00384373	0.00043299	0.00019471	0.00033400	0.00056026	0.00000001	0.00032424
+CC[T>C]GC	0.00071013	0.00023095	0.00007789	0.00033400	0.00037351	0.00000002	0.00000001
+CC[T>C]GG	0.00156680	0.00037529	0.00070099	0.00033400	0.00028013	0.00065876	0.00000001
+CC[T>C]GT	0.00147662	0.00054851	0.00046732	0.00020875	0.00079372	0.00037643	0.00000001
+CC[T>C]TA	0.00041706	0.00014434	0.00003895	0.00029225	0.00000001	0.00018821	0.00040532
+CC[T>C]TC	0.00031561	0.00038975	0.00066205	0.00075151	0.00000001	0.00018822	0.00032425
+CC[T>C]TG	0.00057487	0.00041861	0.00054521	0.00045925	0.00051358	0.00037643	0.00081063
+CC[T>C]TT	0.00255873	0.00046188	0.00085676	0.00058450	0.00079371	0.00028231	0.00089169
+CC[T>G]AA	0.00013526	0.00018766	0.00027261	0.00054276	0.00056028	0.00009412	0.00016213
+CC[T>G]AC	0.00003382	0.00004331	0.00000001	0.00000001	0.00046690	0.00000002	0.00000002
+CC[T>G]AG	0.00003382	0.00014435	0.00003895	0.00012525	0.00018676	0.00000002	0.00000001
+CC[T>G]AT	0.00016908	0.00011548	0.00019472	0.00016700	0.00000001	0.00000002	0.00000001
+CC[T>G]CA	0.00050724	0.00028870	0.00038944	0.00016700	0.00037352	0.00028232	0.00008107
+CC[T>G]CC	0.00013526	0.00025983	0.00031155	0.00029225	0.00014007	0.00047054	0.00008107
+CC[T>G]CG	0.00004509	0.00000000	0.00000001	0.00016700	0.00000001	0.00000002	0.00000002
+CC[T>G]CT	0.00031561	0.00023096	0.00007789	0.00000001	0.00028014	0.00000002	0.00008107
+CC[T>G]GA	0.00025925	0.00025983	0.00038944	0.00087676	0.00037352	0.00028232	0.00048638
+CC[T>G]GC	0.00014653	0.00037532	0.00000000	0.00012525	0.00065366	0.00009412	0.00016212
+CC[T>G]GG	0.00023671	0.00023096	0.00019472	0.00016700	0.00032683	0.00000002	0.00000001
+CC[T>G]GT	0.00045088	0.00030313	0.00023366	0.00050100	0.00023345	0.00000002	0.00000001
+CC[T>G]TA	0.00024798	0.00040419	0.00011683	0.00012525	0.00065366	0.00000002	0.00024319
+CC[T>G]TC	0.00042833	0.00010104	0.00019472	0.00025050	0.00084041	0.00009412	0.00008107
+CC[T>G]TG	0.00047342	0.00024539	0.00019472	0.00012525	0.00056028	0.00009412	0.00000001
+CC[T>G]TT	0.00098066	0.00017320	0.00035049	0.00029225	0.00070034	0.00037643	0.00000001
+CG[C>A]AA	0.00005636	0.00001444	0.00050627	0.00004175	0.00000001	0.00009412	0.00000001
+CG[C>A]AC	0.00000000	0.00004331	0.00000001	0.00008350	0.00000001	0.00009412	0.00000002
+CG[C>A]AG	0.00004509	0.00000000	0.00011684	0.00008351	0.00000001	0.00000002	0.00008107
+CG[C>A]AT	0.00000000	0.00011548	0.00011683	0.00000001	0.00009338	0.00000002	0.00032426
+CG[C>A]CA	0.00011272	0.00002887	0.00000001	0.00004175	0.00000001	0.00000002	0.00000002
+CG[C>A]CC	0.00001127	0.00007217	0.00000001	0.00008350	0.00000001	0.00037643	0.00000002
+CG[C>A]CG	0.00000000	0.00000000	0.00000001	0.00000001	0.00009338	0.00000002	0.00000002
+CG[C>A]CT	0.00006763	0.00014435	0.00000001	0.00029225	0.00018676	0.00028233	0.00008107
+CG[C>A]GA	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00009412	0.00000002
+CG[C>A]GC	0.00001127	0.00002887	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[C>A]GG	0.00000000	0.00004331	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[C>A]GT	0.00001127	0.00004331	0.00000001	0.00000001	0.00004669	0.00000002	0.00000002
+CG[C>A]TA	0.00015781	0.00002887	0.00011683	0.00008350	0.00000001	0.00000002	0.00000002
+CG[C>A]TC	0.00023671	0.00007217	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[C>A]TG	0.00023671	0.00002887	0.00000001	0.00000001	0.00023345	0.00009412	0.00000002
+CG[C>A]TT	0.00025925	0.00007217	0.00015578	0.00004175	0.00000001	0.00028232	0.00016213
+CG[C>G]AA	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[C>G]AC	0.00000000	0.00001444	0.00000001	0.00025050	0.00000001	0.00000002	0.00000002
+CG[C>G]AG	0.00004509	0.00002887	0.00000001	0.00016701	0.00000001	0.00028234	0.00000002
+CG[C>G]AT	0.00000000	0.00000000	0.00000001	0.00000001	0.00014007	0.00000002	0.00000002
+CG[C>G]CA	0.00000000	0.00002887	0.00000001	0.00000001	0.00009338	0.00000002	0.00000002
+CG[C>G]CC	0.00002254	0.00020209	0.00019472	0.00000001	0.00000001	0.00037643	0.00000001
+CG[C>G]CG	0.00000000	0.00008661	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[C>G]CT	0.00000000	0.00000000	0.00000001	0.00008351	0.00009338	0.00000002	0.00000002
+CG[C>G]GA	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[C>G]GC	0.00001127	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00016213
+CG[C>G]GG	0.00003382	0.00000000	0.00000001	0.00008351	0.00000001	0.00000002	0.00000002
+CG[C>G]GT	0.00000000	0.00001444	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[C>G]TA	0.00000000	0.00004331	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[C>G]TC	0.00001127	0.00007218	0.00000001	0.00016700	0.00000001	0.00000002	0.00000002
+CG[C>G]TG	0.00006763	0.00004330	0.00027261	0.00000001	0.00000001	0.00000002	0.00000002
+CG[C>G]TT	0.00000000	0.00000000	0.00011683	0.00000001	0.00000001	0.00018823	0.00000002
+CG[C>T]AA	0.00022544	0.00002886	0.00000001	0.00004175	0.00000001	0.00018821	0.00024320
+CG[C>T]AC	0.00024798	0.00023096	0.00007789	0.00045925	0.00046690	0.00009411	0.00064851
+CG[C>T]AG	0.00045088	0.00011547	0.00011683	0.00008350	0.00018676	0.00094108	0.00024319
+CG[C>T]AT	0.00032689	0.00017322	0.00007789	0.00004175	0.00028014	0.00009412	0.00024320
+CG[C>T]CA	0.00090175	0.00007216	0.00003895	0.00029225	0.00018675	0.00037643	0.00008107
+CG[C>T]CC	0.00057487	0.00012990	0.00035050	0.00050100	0.00014007	0.00018822	0.00008107
+CG[C>T]CG	0.00029307	0.00001443	0.00000001	0.00000001	0.00004669	0.00000002	0.00000002
+CG[C>T]CT	0.00078903	0.00012989	0.00046733	0.00045925	0.00009338	0.00084697	0.00097276
+CG[C>T]GA	0.00094684	0.00049078	0.00050627	0.00121076	0.00107386	0.00075286	0.00056744
+CG[C>T]GC	0.00214167	0.00038969	0.00144093	0.00158651	0.00168082	0.00338790	0.00105382
+CG[C>T]GG	0.00175842	0.00070727	0.00120726	0.00141951	0.00177420	0.00150571	0.00364786
+CG[C>T]GT	0.00144281	0.00037529	0.00027261	0.00066800	0.00018675	0.00065875	0.00089170
+CG[C>T]TA	0.00029307	0.00004330	0.00007789	0.00000001	0.00000001	0.00000002	0.00000002
+CG[C>T]TC	0.00040579	0.00005773	0.00007789	0.00008350	0.00028014	0.00000002	0.00000001
+CG[C>T]TG	0.00056360	0.00021652	0.00031155	0.00004175	0.00000001	0.00000002	0.00000001
+CG[C>T]TT	0.00033816	0.00012991	0.00019472	0.00008350	0.00004669	0.00037643	0.00016213
+CG[T>A]AA	0.00000000	0.00000000	0.00000001	0.00000001	0.00009338	0.00000002	0.00000002
+CG[T>A]AC	0.00000000	0.00000000	0.00003895	0.00000001	0.00000001	0.00000002	0.00000002
+CG[T>A]AG	0.00000000	0.00004330	0.00003895	0.00000001	0.00000001	0.00065876	0.00000002
+CG[T>A]AT	0.00000000	0.00021653	0.00000001	0.00008350	0.00000001	0.00065876	0.00008107
+CG[T>A]CA	0.00000000	0.00004331	0.00015578	0.00000001	0.00000001	0.00000002	0.00000002
+CG[T>A]CC	0.00006763	0.00004330	0.00000001	0.00000001	0.00009338	0.00000002	0.00000002
+CG[T>A]CG	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[T>A]CT	0.00000000	0.00007218	0.00003895	0.00000001	0.00000001	0.00000002	0.00000002
+CG[T>A]GA	0.00004509	0.00004331	0.00011683	0.00000001	0.00023345	0.00000002	0.00000002
+CG[T>A]GC	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[T>A]GG	0.00000000	0.00017322	0.00007789	0.00004175	0.00000001	0.00018822	0.00032426
+CG[T>A]GT	0.00000000	0.00002887	0.00000001	0.00016701	0.00004669	0.00000002	0.00016213
+CG[T>A]TA	0.00003382	0.00001444	0.00000001	0.00000001	0.00000001	0.00037644	0.00000002
+CG[T>A]TC	0.00001127	0.00005774	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[T>A]TG	0.00004509	0.00000000	0.00000001	0.00000001	0.00000001	0.00018823	0.00000002
+CG[T>A]TT	0.00000000	0.00002887	0.00000001	0.00008350	0.00014007	0.00028233	0.00000002
+CG[T>C]AA	0.00011272	0.00005774	0.00000001	0.00000001	0.00009338	0.00000002	0.00016213
+CG[T>C]AC	0.00009018	0.00008661	0.00000001	0.00000001	0.00000001	0.00018822	0.00024320
+CG[T>C]AG	0.00015781	0.00004330	0.00000001	0.00004175	0.00004669	0.00000002	0.00000002
+CG[T>C]AT	0.00015781	0.00027427	0.00003895	0.00000001	0.00014007	0.00037643	0.00024319
+CG[T>C]CA	0.00016908	0.00004330	0.00003895	0.00016700	0.00000001	0.00000002	0.00000002
+CG[T>C]CC	0.00009018	0.00007218	0.00000001	0.00012525	0.00000001	0.00000002	0.00000002
+CG[T>C]CG	0.00004509	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[T>C]CT	0.00014654	0.00014435	0.00042838	0.00000001	0.00000001	0.00000002	0.00000001
+CG[T>C]GA	0.00046215	0.00018765	0.00011683	0.00016700	0.00009338	0.00018823	0.00000001
+CG[T>C]GC	0.00024798	0.00007217	0.00023366	0.00000001	0.00023345	0.00000002	0.00000001
+CG[T>C]GG	0.00019162	0.00012992	0.00000001	0.00033400	0.00009338	0.00000002	0.00000001
+CG[T>C]GT	0.00023671	0.00004330	0.00011683	0.00020875	0.00000001	0.00000002	0.00000001
+CG[T>C]TA	0.00002254	0.00001444	0.00000001	0.00012525	0.00009338	0.00000002	0.00000002
+CG[T>C]TC	0.00010145	0.00007218	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[T>C]TG	0.00004509	0.00007218	0.00003895	0.00041750	0.00000001	0.00000002	0.00000001
+CG[T>C]TT	0.00004509	0.00004331	0.00011683	0.00000001	0.00000001	0.00018822	0.00000002
+CG[T>G]AA	0.00000000	0.00000000	0.00000001	0.00016700	0.00000001	0.00000002	0.00000002
+CG[T>G]AC	0.00002254	0.00000000	0.00000001	0.00004175	0.00000001	0.00000002	0.00000002
+CG[T>G]AG	0.00000000	0.00008661	0.00007789	0.00000001	0.00000001	0.00000002	0.00000002
+CG[T>G]AT	0.00000000	0.00000000	0.00019472	0.00012525	0.00000001	0.00009412	0.00000002
+CG[T>G]CA	0.00002254	0.00001444	0.00000001	0.00000001	0.00000001	0.00000002	0.00008107
+CG[T>G]CC	0.00000000	0.00000000	0.00000001	0.00004175	0.00004669	0.00000002	0.00000002
+CG[T>G]CG	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[T>G]CT	0.00000000	0.00000000	0.00007789	0.00000001	0.00000001	0.00037643	0.00000002
+CG[T>G]GA	0.00000000	0.00000000	0.00003895	0.00000001	0.00000001	0.00000002	0.00000002
+CG[T>G]GC	0.00000000	0.00002887	0.00000001	0.00000001	0.00009338	0.00000002	0.00000002
+CG[T>G]GG	0.00003382	0.00000000	0.00003895	0.00012525	0.00000001	0.00000002	0.00008107
+CG[T>G]GT	0.00000000	0.00002887	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CG[T>G]TA	0.00002254	0.00002887	0.00000001	0.00000001	0.00004669	0.00000002	0.00000002
+CG[T>G]TC	0.00000000	0.00002887	0.00000001	0.00000001	0.00009338	0.00000002	0.00000002
+CG[T>G]TG	0.00000000	0.00007218	0.00000001	0.00008350	0.00032683	0.00000002	0.00000002
+CG[T>G]TT	0.00001127	0.00008661	0.00000001	0.00008350	0.00000001	0.00000002	0.00008107
+CT[C>A]AA	0.00042833	0.00141465	0.00058415	0.00096025	0.00074704	0.00178806	0.00081063
+CT[C>A]AC	0.00027053	0.00132805	0.00093465	0.00079325	0.00093380	0.00037643	0.00081062
+CT[C>A]AG	0.00052978	0.00197763	0.00128514	0.00183700	0.00046689	0.00094108	0.00097275
+CT[C>A]AT	0.00050724	0.00171780	0.00105148	0.00070974	0.00079372	0.00169395	0.00064850
+CT[C>A]CA	0.00116101	0.00089496	0.00116832	0.00121075	0.00060696	0.00272915	0.00081062
+CT[C>A]CC	0.00040579	0.00128474	0.00109043	0.00096025	0.00074704	0.00131752	0.00056743
+CT[C>A]CG	0.00000000	0.00020210	0.00000001	0.00016700	0.00000001	0.00009412	0.00000001
+CT[C>A]CT	0.00059741	0.00111150	0.00214192	0.00158651	0.00056027	0.00235271	0.00145913
+CT[C>A]GA	0.00013526	0.00014435	0.00027261	0.00012525	0.00023345	0.00075287	0.00000001
+CT[C>A]GC	0.00007890	0.00014435	0.00046733	0.00004175	0.00000001	0.00000002	0.00000001
+CT[C>A]GG	0.00009017	0.00047637	0.00050627	0.00025050	0.00056028	0.00018823	0.00016212
+CT[C>A]GT	0.00004509	0.00028871	0.00007789	0.00033400	0.00018676	0.00009412	0.00008107
+CT[C>A]TA	0.00158934	0.00072173	0.00101254	0.00087675	0.00018675	0.00103519	0.00056744
+CT[C>A]TC	0.00153298	0.00095269	0.00124620	0.00062625	0.00046689	0.00141162	0.00064850
+CT[C>A]TG	0.00233329	0.00127026	0.00175247	0.00091850	0.00116723	0.00169394	0.00145913
+CT[C>A]TT	0.00188241	0.00138575	0.00194719	0.00096025	0.00121393	0.00282325	0.00089168
+CT[C>G]AA	0.00117227	0.01192360	0.00377750	0.01185704	0.00107386	0.00112925	0.00656606
+CT[C>G]AC	0.00031561	0.00271385	0.00066203	0.00304776	0.00042021	0.00028232	0.00040529
+CT[C>G]AG	0.00072140	0.00812712	0.00151876	0.00830828	0.00070034	0.00037643	0.00186439
+CT[C>G]AT	0.00025925	0.00388312	0.00140196	0.00450902	0.00060697	0.00018821	0.00259400
+CT[C>G]CA	0.00043960	0.00345005	0.00241451	0.00300601	0.00060696	0.00009410	0.00202656
+CT[C>G]CC	0.00023671	0.00148684	0.00031154	0.00137775	0.00028014	0.00037643	0.00000000
+CT[C>G]CG	0.00001127	0.00037532	0.00000000	0.00066800	0.00014007	0.00000002	0.00000001
+CT[C>G]CT	0.00034943	0.00252619	0.00089570	0.00192050	0.00032683	0.00000001	0.00040531
+CT[C>G]GA	0.00013526	0.00088056	0.00038943	0.00075150	0.00042021	0.00000002	0.00016213
+CT[C>G]GC	0.00002254	0.00024540	0.00000001	0.00029225	0.00004669	0.00037644	0.00000001
+CT[C>G]GG	0.00004509	0.00062072	0.00031155	0.00054275	0.00009338	0.00000002	0.00000001
+CT[C>G]GT	0.00000000	0.00030314	0.00023366	0.00041750	0.00014007	0.00028233	0.00024319
+CT[C>G]TA	0.00060868	0.00731873	0.00128510	0.00442549	0.00126062	0.00094106	0.00380994
+CT[C>G]TC	0.00029307	0.00447496	0.00167457	0.00430026	0.00051359	0.00084696	0.00235081
+CT[C>G]TG	0.00085666	0.00740534	0.00147982	0.00697227	0.00219442	0.00037640	0.00486376
+CT[C>G]TT	0.00043960	0.00828590	0.00272603	0.00655475	0.00144738	0.00197625	0.00429631
+CT[C>T]AA	0.00098065	0.00421511	0.00249239	0.00308950	0.00126062	0.00094105	0.00445847
+CT[C>T]AC	0.00093557	0.00593292	0.00190822	0.00317298	0.00130731	0.00103517	0.00356676
+CT[C>T]AG	0.00207403	0.01058108	0.00432272	0.00738974	0.00224110	0.00376428	0.00834948
+CT[C>T]AT	0.00094684	0.00578856	0.00420593	0.00563627	0.00084041	0.00244679	0.00437739
+CT[C>T]CA	0.00095811	0.00177553	0.00128514	0.00125250	0.00149407	0.00018820	0.00178339
+CT[C>T]CC	0.00109338	0.00229520	0.00167458	0.00141949	0.00130731	0.00131750	0.00194551
+CT[C>T]CG	0.00027053	0.00027427	0.00035050	0.00029225	0.00014007	0.00018822	0.00016212
+CT[C>T]CT	0.00069886	0.00306028	0.00334917	0.00237975	0.00172752	0.00178805	0.00121592
+CT[C>T]GA	0.00129627	0.00089495	0.00171353	0.00104375	0.00130731	0.00235270	0.00162126
+CT[C>T]GC	0.00144281	0.00118366	0.00105148	0.00208751	0.00168082	0.00112929	0.00178339
+CT[C>T]GG	0.00326886	0.00222295	0.00237557	0.00338177	0.00266130	0.00414073	0.00591763
+CT[C>T]GT	0.00149916	0.00168890	0.00186930	0.00254676	0.00158745	0.00301147	0.00154019
+CT[C>T]TA	0.00056359	0.00174665	0.00101253	0.00150300	0.00116724	0.00094106	0.00316147
+CT[C>T]TC	0.00067631	0.00203537	0.00167458	0.00150300	0.00121393	0.00075285	0.00162126
+CT[C>T]TG	0.00123991	0.00414292	0.00268711	0.00450902	0.00121393	0.00122339	0.00308038
+CT[C>T]TT	0.00116101	0.00369542	0.00233662	0.00208749	0.00163414	0.00272913	0.00210762
+CT[T>A]AA	0.00018035	0.00034644	0.00035050	0.00058450	0.00009338	0.00000001	0.00072957
+CT[T>A]AC	0.00004509	0.00033201	0.00000000	0.00004175	0.00023345	0.00009411	0.00048638
+CT[T>A]AG	0.00004509	0.00040419	0.00011683	0.00029225	0.00042021	0.00000002	0.00008107
+CT[T>A]AT	0.00009017	0.00043306	0.00031155	0.00087676	0.00042021	0.00000001	0.00048638
+CT[T>A]CA	0.00007890	0.00025984	0.00050627	0.00008350	0.00014007	0.00000002	0.00000001
+CT[T>A]CC	0.00002254	0.00044750	0.00000000	0.00020875	0.00023345	0.00018823	0.00000001
+CT[T>A]CG	0.00006763	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CT[T>A]CT	0.00007890	0.00049080	0.00046733	0.00041750	0.00014007	0.00094109	0.00016212
+CT[T>A]GA	0.00000000	0.00015879	0.00011683	0.00016700	0.00032683	0.00000002	0.00000001
+CT[T>A]GC	0.00001127	0.00005774	0.00011683	0.00004175	0.00009338	0.00000002	0.00000002
+CT[T>A]GG	0.00010145	0.00020209	0.00015577	0.00033400	0.00009338	0.00000002	0.00016213
+CT[T>A]GT	0.00003382	0.00028870	0.00031155	0.00020875	0.00023345	0.00000001	0.00048638
+CT[T>A]TA	0.00007890	0.00025983	0.00077888	0.00050100	0.00028014	0.00000001	0.00072957
+CT[T>A]TC	0.00000000	0.00050524	0.00023366	0.00050100	0.00014007	0.00000002	0.00024319
+CT[T>A]TG	0.00009018	0.00007218	0.00031155	0.00016700	0.00009338	0.00028234	0.00008107
+CT[T>A]TT	0.00014653	0.00067846	0.00101254	0.00045925	0.00023345	0.00018822	0.00032426
+CT[T>C]AA	0.00085667	0.00028869	0.00054521	0.00037575	0.00037351	0.00018821	0.00016213
+CT[T>C]AC	0.00091303	0.00023095	0.00062310	0.00004175	0.00112055	0.00000002	0.00000001
+CT[T>C]AG	0.00048469	0.00027426	0.00007788	0.00033400	0.00060697	0.00028233	0.00000001
+CT[T>C]AT	0.00064250	0.00056297	0.00035049	0.00079325	0.00112055	0.00009411	0.00032425
+CT[T>C]CA	0.00094684	0.00051965	0.00042838	0.00029225	0.00088710	0.00065876	0.00024318
+CT[T>C]CC	0.00068759	0.00043305	0.00035049	0.00079326	0.00028014	0.00000001	0.00024319
+CT[T>C]CG	0.00003382	0.00005774	0.00000001	0.00008350	0.00000001	0.00000002	0.00016214
+CT[T>C]CT	0.00030434	0.00066402	0.00105149	0.00104376	0.00037352	0.00018822	0.00129701
+CT[T>C]GA	0.00153298	0.00024537	0.00062310	0.00008350	0.00018675	0.00028233	0.00048638
+CT[T>C]GC	0.00054105	0.00010104	0.00054522	0.00029225	0.00004669	0.00037643	0.00000001
+CT[T>C]GG	0.00126246	0.00027424	0.00058416	0.00045925	0.00023345	0.00065876	0.00000001
+CT[T>C]GT	0.00081158	0.00020208	0.00038944	0.00050100	0.00023345	0.00047054	0.00000001
+CT[T>C]TA	0.00031561	0.00020209	0.00003895	0.00062626	0.00032683	0.00047054	0.00000001
+CT[T>C]TC	0.00078903	0.00025982	0.00042838	0.00062625	0.00056027	0.00028232	0.00032425
+CT[T>C]TG	0.00098066	0.00044747	0.00035049	0.00050100	0.00046689	0.00065875	0.00089170
+CT[T>C]TT	0.00139772	0.00072174	0.00120726	0.00112726	0.00102717	0.00000001	0.00032424
+CT[T>G]AA	0.00020289	0.00041862	0.00003894	0.00016700	0.00065366	0.00075287	0.00024320
+CT[T>G]AC	0.00003382	0.00004331	0.00000001	0.00025050	0.00028014	0.00000002	0.00000001
+CT[T>G]AG	0.00000000	0.00008661	0.00023366	0.00000001	0.00028014	0.00000002	0.00000002
+CT[T>G]AT	0.00004509	0.00008661	0.00031155	0.00000001	0.00088711	0.00028233	0.00000001
+CT[T>G]CA	0.00013526	0.00004330	0.00007789	0.00020876	0.00028014	0.00000002	0.00024320
+CT[T>G]CC	0.00001127	0.00024540	0.00003895	0.00008350	0.00037352	0.00009412	0.00024320
+CT[T>G]CG	0.00000000	0.00005774	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+CT[T>G]CT	0.00004509	0.00021653	0.00011683	0.00012525	0.00154076	0.00018822	0.00024319
+CT[T>G]GA	0.00002254	0.00038975	0.00031155	0.00008350	0.00023345	0.00056465	0.00056744
+CT[T>G]GC	0.00006763	0.00020209	0.00000001	0.00000001	0.00009338	0.00018822	0.00032425
+CT[T>G]GG	0.00002254	0.00021653	0.00007789	0.00062626	0.00018676	0.00047054	0.00000001
+CT[T>G]GT	0.00006763	0.00023097	0.00035049	0.00008350	0.00056028	0.00000002	0.00000001
+CT[T>G]TA	0.00019162	0.00031757	0.00003894	0.00045925	0.00093380	0.00084698	0.00040532
+CT[T>G]TC	0.00003381	0.00040419	0.00011682	0.00016700	0.00298815	0.00018823	0.00000001
+CT[T>G]TG	0.00019162	0.00010104	0.00023366	0.00058451	0.00116724	0.00075287	0.00008107
+CT[T>G]TT	0.00033816	0.00041862	0.00066204	0.00041750	0.00149407	0.00047054	0.00040531
+GA[C>A]AA	0.00034943	0.00102490	0.00101254	0.00075150	0.00046690	0.00103519	0.00137807
+GA[C>A]AC	0.00021417	0.00030314	0.00038944	0.00016700	0.00102718	0.00037644	0.00040532
+GA[C>A]AG	0.00014653	0.00037531	0.00058416	0.00087676	0.00070035	0.00075286	0.00081063
+GA[C>A]AT	0.00013526	0.00069289	0.00050627	0.00154476	0.00084042	0.00000001	0.00081063
+GA[C>A]CA	0.00025925	0.00060628	0.00027260	0.00041750	0.00074704	0.00141163	0.00072957
+GA[C>A]CC	0.00005636	0.00036088	0.00066205	0.00004175	0.00116725	0.00084698	0.00016213
+GA[C>A]CG	0.00003382	0.00012992	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GA[C>A]CT	0.00031561	0.00049080	0.00058416	0.00070975	0.00065366	0.00056465	0.00016212
+GA[C>A]GA	0.00006763	0.00014435	0.00003895	0.00000001	0.00000001	0.00000002	0.00000002
+GA[C>A]GC	0.00002254	0.00000000	0.00003895	0.00000001	0.00000001	0.00000002	0.00000002
+GA[C>A]GG	0.00000000	0.00005774	0.00031155	0.00012525	0.00023345	0.00037644	0.00040532
+GA[C>A]GT	0.00000000	0.00004331	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GA[C>A]TA	0.00032689	0.00043305	0.00066205	0.00025050	0.00032683	0.00009411	0.00024319
+GA[C>A]TC	0.00041706	0.00015878	0.00077888	0.00004175	0.00028014	0.00018822	0.00000001
+GA[C>A]TG	0.00055232	0.00036087	0.00066205	0.00054275	0.00056027	0.00000001	0.00072957
+GA[C>A]TT	0.00037197	0.00059184	0.00070099	0.00133601	0.00042021	0.00094108	0.00081063
+GA[C>G]AA	0.00007890	0.00072177	0.00050627	0.00066800	0.00009338	0.00065876	0.00056744
+GA[C>G]AC	0.00007890	0.00024540	0.00000001	0.00054276	0.00000001	0.00000002	0.00032425
+GA[C>G]AG	0.00034943	0.00044749	0.00054521	0.00029225	0.00014007	0.00009412	0.00024319
+GA[C>G]AT	0.00003382	0.00034645	0.00046733	0.00025050	0.00000001	0.00047054	0.00000001
+GA[C>G]CA	0.00011272	0.00027427	0.00097360	0.00062625	0.00065366	0.00018821	0.00072957
+GA[C>G]CC	0.00000000	0.00015879	0.00003895	0.00016700	0.00000001	0.00000002	0.00000001
+GA[C>G]CG	0.00001127	0.00002887	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GA[C>G]CT	0.00003382	0.00018766	0.00050627	0.00029225	0.00023345	0.00000002	0.00016212
+GA[C>G]GA	0.00000000	0.00001444	0.00019472	0.00041750	0.00004669	0.00000002	0.00000001
+GA[C>G]GC	0.00003382	0.00002887	0.00003895	0.00016700	0.00014007	0.00000002	0.00000002
+GA[C>G]GG	0.00000000	0.00005774	0.00035050	0.00000001	0.00000001	0.00028234	0.00000002
+GA[C>G]GT	0.00002254	0.00000000	0.00003895	0.00012525	0.00000001	0.00000002	0.00000002
+GA[C>G]TA	0.00013526	0.00024540	0.00000001	0.00025050	0.00023345	0.00018823	0.00008107
+GA[C>G]TC	0.00011272	0.00011548	0.00046733	0.00016700	0.00018676	0.00000002	0.00032426
+GA[C>G]TG	0.00015781	0.00046193	0.00015577	0.00025050	0.00065366	0.00000001	0.00048638
+GA[C>G]TT	0.00020289	0.00031757	0.00062310	0.00045925	0.00046690	0.00056465	0.00024319
+GA[C>T]AA	0.00099193	0.00034642	0.00105149	0.00012525	0.00084041	0.00075286	0.00048638
+GA[C>T]AC	0.00126246	0.00040416	0.00038944	0.00054275	0.00088710	0.00056464	0.00081063
+GA[C>T]AG	0.00238965	0.00040413	0.00066205	0.00066800	0.00056027	0.00075286	0.00097276
+GA[C>T]AT	0.00207403	0.00095269	0.00167459	0.00045924	0.00214772	0.00178806	0.00048637
+GA[C>T]CA	0.00135263	0.00057739	0.00023366	0.00070975	0.00046689	0.00009411	0.00072957
+GA[C>T]CC	0.00061996	0.00054853	0.00042838	0.00008349	0.00060696	0.00037644	0.00064851
+GA[C>T]CG	0.00023671	0.00005774	0.00003895	0.00000001	0.00000001	0.00000002	0.00000002
+GA[C>T]CT	0.00066504	0.00037530	0.00038944	0.00008350	0.00065365	0.00075287	0.00008107
+GA[C>T]GA	0.00317868	0.00101038	0.00272608	0.00317302	0.00219440	0.00574061	0.00267508
+GA[C>T]GC	0.00305469	0.00093821	0.00190825	0.00229627	0.00275468	0.00404664	0.00332360
+GA[C>T]GG	0.00533162	0.00132791	0.00385545	0.00446729	0.00429544	0.00282321	0.00543124
+GA[C>T]GT	0.00335903	0.00089491	0.00167459	0.00200401	0.00182089	0.00207036	0.00275615
+GA[C>T]TA	0.00051851	0.00031757	0.00073994	0.00025050	0.00032683	0.00018821	0.00016213
+GA[C>T]TC	0.00059741	0.00023095	0.00054522	0.00020875	0.00014007	0.00028232	0.00032425
+GA[C>T]TG	0.00151044	0.00017319	0.00038944	0.00058450	0.00023344	0.00018821	0.00016212
+GA[C>T]TT	0.00091303	0.00060626	0.00089571	0.00070975	0.00000000	0.00103519	0.00032425
+GA[T>A]AA	0.00025925	0.00073620	0.00128515	0.00020875	0.00070035	0.00028232	0.00048638
+GA[T>A]AC	0.00014653	0.00012991	0.00015578	0.00016700	0.00014007	0.00009411	0.00040532
+GA[T>A]AG	0.00006763	0.00024540	0.00011683	0.00012525	0.00032683	0.00018822	0.00000001
+GA[T>A]AT	0.00007890	0.00020209	0.00027261	0.00020875	0.00009338	0.00047054	0.00016213
+GA[T>A]CA	0.00025925	0.00007217	0.00038944	0.00054276	0.00042021	0.00018821	0.00032425
+GA[T>A]CC	0.00007890	0.00024540	0.00000001	0.00008350	0.00004669	0.00009411	0.00064851
+GA[T>A]CG	0.00000000	0.00000000	0.00000001	0.00000001	0.00009338	0.00000002	0.00000002
+GA[T>A]CT	0.00010145	0.00044749	0.00042838	0.00025050	0.00032683	0.00028232	0.00008107
+GA[T>A]GA	0.00005636	0.00057741	0.00046732	0.00029225	0.00070035	0.00000002	0.00024319
+GA[T>A]GC	0.00004509	0.00021653	0.00007789	0.00008350	0.00000001	0.00000002	0.00000001
+GA[T>A]GG	0.00012399	0.00041862	0.00031155	0.00000000	0.00070035	0.00056465	0.00016212
+GA[T>A]GT	0.00003382	0.00040419	0.00023366	0.00041750	0.00042021	0.00000002	0.00032425
+GA[T>A]TA	0.00027053	0.00056296	0.00050627	0.00020875	0.00032683	0.00112930	0.00097276
+GA[T>A]TC	0.00010145	0.00027427	0.00011683	0.00075151	0.00088711	0.00018821	0.00056744
+GA[T>A]TG	0.00025925	0.00036088	0.00066205	0.00008350	0.00004669	0.00000002	0.00024319
+GA[T>A]TT	0.00039452	0.00064959	0.00027260	0.00037575	0.00079372	0.00018822	0.00016213
+GA[T>C]AA	0.00036070	0.00077950	0.00031155	0.00050100	0.00088711	0.00112930	0.00097276
+GA[T>C]AC	0.00060868	0.00054853	0.00031155	0.00041750	0.00060697	0.00084697	0.00064851
+GA[T>C]AG	0.00048469	0.00083723	0.00038943	0.00041750	0.00070034	0.00094108	0.00097276
+GA[T>C]AT	0.00037197	0.00072175	0.00089571	0.00087675	0.00065365	0.00122341	0.00072957
+GA[T>C]CA	0.00049596	0.00037531	0.00023366	0.00070975	0.00014007	0.00065876	0.00016212
+GA[T>C]CC	0.00013526	0.00010105	0.00046733	0.00045925	0.00018676	0.00000002	0.00000001
+GA[T>C]CG	0.00004509	0.00008661	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GA[T>C]CT	0.00014653	0.00047636	0.00015577	0.00025050	0.00037352	0.00009412	0.00016213
+GA[T>C]GA	0.00122864	0.00041860	0.00105149	0.00020875	0.00056027	0.00047054	0.00032425
+GA[T>C]GC	0.00047342	0.00021652	0.00000001	0.00045925	0.00000001	0.00000002	0.00024319
+GA[T>C]GG	0.00076649	0.00069288	0.00046732	0.00020874	0.00102717	0.00047054	0.00056744
+GA[T>C]GT	0.00048469	0.00028869	0.00042838	0.00033400	0.00056028	0.00037643	0.00048638
+GA[T>C]TA	0.00040579	0.00047636	0.00023366	0.00033400	0.00060697	0.00037643	0.00008107
+GA[T>C]TC	0.00022544	0.00036087	0.00011683	0.00008350	0.00018676	0.00037643	0.00137808
+GA[T>C]TG	0.00039452	0.00049079	0.00105149	0.00129426	0.00098048	0.00056464	0.00129701
+GA[T>C]TT	0.00038324	0.00082280	0.00023366	0.00100200	0.00102717	0.00094108	0.00137808
+GA[T>G]AA	0.00003382	0.00024540	0.00019472	0.00020875	0.00018676	0.00028233	0.00000001
+GA[T>G]AC	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GA[T>G]AG	0.00000000	0.00007218	0.00035050	0.00025050	0.00023345	0.00009412	0.00000001
+GA[T>G]AT	0.00002254	0.00002887	0.00007789	0.00000001	0.00028014	0.00000002	0.00000002
+GA[T>G]CA	0.00007890	0.00007218	0.00000001	0.00025050	0.00000001	0.00000002	0.00000002
+GA[T>G]CC	0.00001127	0.00002887	0.00031155	0.00000001	0.00009338	0.00018823	0.00000002
+GA[T>G]CG	0.00001127	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00016214
+GA[T>G]CT	0.00002254	0.00007218	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GA[T>G]GA	0.00002254	0.00011548	0.00003895	0.00012525	0.00018676	0.00000002	0.00000002
+GA[T>G]GC	0.00003382	0.00018766	0.00000001	0.00012525	0.00014007	0.00000002	0.00024319
+GA[T>G]GG	0.00002254	0.00010105	0.00023366	0.00000001	0.00004669	0.00000002	0.00000002
+GA[T>G]GT	0.00005636	0.00015879	0.00015577	0.00033400	0.00046690	0.00028234	0.00000001
+GA[T>G]TA	0.00004509	0.00004330	0.00003894	0.00012525	0.00126063	0.00000002	0.00016214
+GA[T>G]TC	0.00004509	0.00011548	0.00011683	0.00020875	0.00037352	0.00000002	0.00000001
+GA[T>G]TG	0.00001127	0.00014435	0.00011683	0.00016700	0.00032683	0.00000002	0.00000001
+GA[T>G]TT	0.00020289	0.00014435	0.00042838	0.00058451	0.00098049	0.00047054	0.00000001
+GC[C>A]AA	0.00066504	0.00069288	0.00062310	0.00058450	0.00042020	0.00075286	0.00048637
+GC[C>A]AC	0.00092430	0.00040417	0.00070099	0.00000000	0.00028013	0.00065875	0.00064850
+GC[C>A]AG	0.00034943	0.00069289	0.00038944	0.00045925	0.00056028	0.00047054	0.00016212
+GC[C>A]AT	0.00103702	0.00066401	0.00023366	0.00025050	0.00042020	0.00018821	0.00040531
+GC[C>A]CA	0.00278417	0.00063510	0.00035049	0.00025049	0.00023343	0.00018822	0.00032425
+GC[C>A]CC	0.00074395	0.00033200	0.00046733	0.00008350	0.00056027	0.00018822	0.00000001
+GC[C>A]CG	0.00021417	0.00012991	0.00007789	0.00000001	0.00009338	0.00037643	0.00008107
+GC[C>A]CT	0.00111592	0.00031755	0.00054521	0.00058450	0.00037351	0.00009411	0.00032425
+GC[C>A]GA	0.00016908	0.00004330	0.00031155	0.00008350	0.00000001	0.00009412	0.00016213
+GC[C>A]GC	0.00012399	0.00010105	0.00015578	0.00012526	0.00000001	0.00000002	0.00000002
+GC[C>A]GG	0.00032689	0.00025983	0.00003895	0.00008350	0.00000001	0.00000002	0.00024319
+GC[C>A]GT	0.00020289	0.00010104	0.00000001	0.00004175	0.00009338	0.00018823	0.00000002
+GC[C>A]TA	0.00307724	0.00038969	0.00000000	0.00000000	0.00037350	0.00084697	0.00048638
+GC[C>A]TC	0.00514000	0.00033191	0.00070099	0.00075150	0.00116722	0.00000000	0.00016212
+GC[C>A]TG	0.00649264	0.00070720	0.00042838	0.00079324	0.00051355	0.00047052	0.00089168
+GC[C>A]TT	0.00411426	0.00066395	0.00023366	0.00058450	0.00056025	0.00047053	0.00056743
+GC[C>G]AA	0.00000000	0.00027427	0.00015577	0.00041750	0.00018676	0.00037643	0.00008107
+GC[C>G]AC	0.00000000	0.00014435	0.00011683	0.00004175	0.00004669	0.00000002	0.00016213
+GC[C>G]AG	0.00001127	0.00031758	0.00015577	0.00075151	0.00042021	0.00000002	0.00016213
+GC[C>G]AT	0.00004509	0.00008661	0.00031155	0.00016700	0.00028014	0.00028233	0.00024319
+GC[C>G]CA	0.00004509	0.00038976	0.00042838	0.00070975	0.00000001	0.00018822	0.00000001
+GC[C>G]CC	0.00002254	0.00030314	0.00000000	0.00000001	0.00051359	0.00000002	0.00000001
+GC[C>G]CG	0.00000000	0.00012992	0.00000001	0.00004175	0.00014007	0.00009412	0.00000002
+GC[C>G]CT	0.00006763	0.00031758	0.00000001	0.00037575	0.00000001	0.00018823	0.00016213
+GC[C>G]GA	0.00000000	0.00012992	0.00019472	0.00004175	0.00009338	0.00028232	0.00024320
+GC[C>G]GC	0.00000000	0.00004331	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GC[C>G]GG	0.00005636	0.00007217	0.00007789	0.00004175	0.00000001	0.00018823	0.00000002
+GC[C>G]GT	0.00000000	0.00002887	0.00003895	0.00000001	0.00000001	0.00000002	0.00000002
+GC[C>G]TA	0.00000000	0.00023096	0.00011683	0.00020875	0.00023345	0.00009412	0.00024319
+GC[C>G]TC	0.00004509	0.00014435	0.00023366	0.00029225	0.00046690	0.00009412	0.00008107
+GC[C>G]TG	0.00021417	0.00027427	0.00038944	0.00070976	0.00032683	0.00000002	0.00016212
+GC[C>G]TT	0.00003382	0.00038975	0.00058416	0.00033400	0.00032683	0.00037643	0.00000001
+GC[C>T]AA	0.00029307	0.00054853	0.00132410	0.00096026	0.00070034	0.00178806	0.00016212
+GC[C>T]AC	0.00022544	0.00066401	0.00112937	0.00083500	0.00079373	0.00159984	0.00113489
+GC[C>T]AG	0.00037197	0.00053409	0.00066205	0.00125251	0.00046690	0.00131752	0.00064850
+GC[C>T]AT	0.00027052	0.00060627	0.00101254	0.00062625	0.00093379	0.00084697	0.00121595
+GC[C>T]CA	0.00140899	0.00063512	0.00175248	0.00083500	0.00084041	0.00056464	0.00137807
+GC[C>T]CC	0.00045088	0.00060627	0.00038944	0.00008350	0.00051359	0.00122341	0.00089170
+GC[C>T]CG	0.00019162	0.00007217	0.00000001	0.00000001	0.00018676	0.00000002	0.00000002
+GC[C>T]CT	0.00056360	0.00062070	0.00089571	0.00037575	0.00074703	0.00112930	0.00081063
+GC[C>T]GA	0.00322377	0.00076500	0.00315446	0.00121075	0.00233447	0.00169393	0.00251296
+GC[C>T]GC	0.00213039	0.00122695	0.00144092	0.00083500	0.00322159	0.00188216	0.00178339
+GC[C>T]GG	0.00303215	0.00086603	0.00272607	0.00158651	0.00354841	0.00423486	0.00372891
+GC[C>T]GT	0.00214167	0.00072172	0.00058415	0.00100200	0.00070034	0.00112929	0.00154020
+GC[C>T]TA	0.00015781	0.00014434	0.00077888	0.00016700	0.00042021	0.00056465	0.00064851
+GC[C>T]TC	0.00050724	0.00096716	0.00136304	0.00100200	0.00088710	0.00094108	0.00056743
+GC[C>T]TG	0.00066504	0.00062070	0.00105149	0.00108551	0.00084041	0.00131751	0.00105382
+GC[C>T]TT	0.00065377	0.00047635	0.00073993	0.00012525	0.00084041	0.00065875	0.00105382
+GC[T>A]AA	0.00005636	0.00033201	0.00042838	0.00016700	0.00028014	0.00084698	0.00032425
+GC[T>A]AC	0.00000000	0.00007218	0.00042838	0.00012525	0.00018676	0.00000002	0.00008107
+GC[T>A]AG	0.00005636	0.00024540	0.00031155	0.00000001	0.00000001	0.00000001	0.00048638
+GC[T>A]AT	0.00009018	0.00043306	0.00000000	0.00012525	0.00018676	0.00000002	0.00024319
+GC[T>A]CA	0.00014653	0.00034644	0.00019472	0.00025050	0.00004669	0.00028233	0.00000001
+GC[T>A]CC	0.00010145	0.00005774	0.00019472	0.00020875	0.00056028	0.00000002	0.00024319
+GC[T>A]CG	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GC[T>A]CT	0.00019162	0.00053410	0.00031155	0.00054275	0.00037352	0.00075287	0.00016212
+GC[T>A]GA	0.00003382	0.00033201	0.00085677	0.00000000	0.00014007	0.00000001	0.00056744
+GC[T>A]GC	0.00011272	0.00036088	0.00007789	0.00004175	0.00014007	0.00018822	0.00000001
+GC[T>A]GG	0.00004509	0.00033201	0.00038944	0.00037575	0.00032683	0.00000002	0.00008107
+GC[T>A]GT	0.00005636	0.00028870	0.00007789	0.00041750	0.00042021	0.00018822	0.00040532
+GC[T>A]TA	0.00007890	0.00040419	0.00023366	0.00008350	0.00009338	0.00000002	0.00000001
+GC[T>A]TC	0.00003382	0.00027427	0.00038944	0.00016700	0.00014007	0.00000002	0.00000001
+GC[T>A]TG	0.00002254	0.00015879	0.00031155	0.00025050	0.00014007	0.00000002	0.00008107
+GC[T>A]TT	0.00012399	0.00041862	0.00027260	0.00025050	0.00042021	0.00000001	0.00064851
+GC[T>C]AA	0.00076649	0.00017321	0.00023366	0.00016700	0.00070034	0.00009411	0.00048638
+GC[T>C]AC	0.00031561	0.00004330	0.00019472	0.00020875	0.00018676	0.00000002	0.00000001
+GC[T>C]AG	0.00028180	0.00030314	0.00000001	0.00004175	0.00004669	0.00028232	0.00016213
+GC[T>C]AT	0.00073268	0.00021652	0.00011683	0.00016700	0.00074703	0.00056466	0.00024320
+GC[T>C]CA	0.00036070	0.00030313	0.00019472	0.00016700	0.00093379	0.00000001	0.00040532
+GC[T>C]CC	0.00028180	0.00028870	0.00000000	0.00037575	0.00032683	0.00047054	0.00000001
+GC[T>C]CG	0.00007890	0.00000000	0.00000001	0.00004175	0.00000001	0.00000002	0.00000002
+GC[T>C]CT	0.00055232	0.00044748	0.00066205	0.00037575	0.00060697	0.00028232	0.00040531
+GC[T>C]GA	0.00253619	0.00043301	0.00023366	0.00050100	0.00074702	0.00037642	0.00089169
+GC[T>C]GC	0.00050724	0.00011547	0.00038944	0.00008350	0.00018676	0.00000001	0.00064851
+GC[T>C]GG	0.00114974	0.00017320	0.00015577	0.00037575	0.00023344	0.00009411	0.00089170
+GC[T>C]GT	0.00091303	0.00031756	0.00035049	0.00004175	0.00032682	0.00009412	0.00000001
+GC[T>C]TA	0.00019162	0.00034645	0.00035049	0.00029225	0.00144738	0.00000002	0.00000001
+GC[T>C]TC	0.00033816	0.00018765	0.00027261	0.00058450	0.00051359	0.00084698	0.00024319
+GC[T>C]TG	0.00016908	0.00025983	0.00015577	0.00058450	0.00070035	0.00047054	0.00000001
+GC[T>C]TT	0.00075522	0.00030313	0.00042838	0.00087676	0.00065365	0.00018821	0.00032426
+GC[T>G]AA	0.00005636	0.00018766	0.00003895	0.00029225	0.00000001	0.00028234	0.00000001
+GC[T>G]AC	0.00001127	0.00014435	0.00000001	0.00033400	0.00004669	0.00000002	0.00000001
+GC[T>G]AG	0.00006763	0.00002887	0.00000001	0.00012526	0.00014007	0.00000002	0.00000002
+GC[T>G]AT	0.00007890	0.00010104	0.00046733	0.00004175	0.00028014	0.00000001	0.00040532
+GC[T>G]CA	0.00022544	0.00008661	0.00011683	0.00016700	0.00018676	0.00065876	0.00008107
+GC[T>G]CC	0.00013526	0.00007217	0.00000001	0.00008350	0.00032683	0.00000002	0.00024319
+GC[T>G]CG	0.00003382	0.00000000	0.00000001	0.00012526	0.00000001	0.00000002	0.00000002
+GC[T>G]CT	0.00016908	0.00014435	0.00003895	0.00000001	0.00023345	0.00037643	0.00000001
+GC[T>G]GA	0.00029307	0.00011548	0.00019472	0.00054276	0.00014007	0.00000002	0.00040532
+GC[T>G]GC	0.00010145	0.00010104	0.00027261	0.00000001	0.00037352	0.00000002	0.00024319
+GC[T>G]GG	0.00005636	0.00020210	0.00007789	0.00033400	0.00009338	0.00009412	0.00000001
+GC[T>G]GT	0.00020289	0.00018766	0.00007789	0.00012525	0.00042021	0.00000002	0.00000001
+GC[T>G]TA	0.00021417	0.00025983	0.00000000	0.00075151	0.00107386	0.00018822	0.00000001
+GC[T>G]TC	0.00039452	0.00030313	0.00000000	0.00037575	0.00093379	0.00065876	0.00000001
+GC[T>G]TG	0.00041706	0.00018765	0.00031155	0.00087676	0.00070034	0.00000002	0.00024319
+GC[T>G]TT	0.00066504	0.00043304	0.00019471	0.00016700	0.00098048	0.00056465	0.00056744
+GG[C>A]AA	0.00050723	0.00135689	0.00307657	0.00200401	0.00172752	0.00432899	0.00137806
+GG[C>A]AC	0.00036070	0.00051966	0.00042838	0.00037575	0.00028014	0.00112930	0.00129701
+GG[C>A]AG	0.00068758	0.00161672	0.00447857	0.00162825	0.00070034	0.00536418	0.00186444
+GG[C>A]AT	0.00031561	0.00060627	0.00167459	0.00045925	0.00065366	0.00169395	0.00129701
+GG[C>A]CA	0.00102575	0.00111150	0.00105148	0.00062625	0.00051358	0.00084697	0.00064850
+GG[C>A]CC	0.00014653	0.00047636	0.00124621	0.00016700	0.00102718	0.00018822	0.00048638
+GG[C>A]CG	0.00011272	0.00017322	0.00027261	0.00000001	0.00018676	0.00000002	0.00000001
+GG[C>A]CT	0.00027053	0.00037531	0.00077888	0.00016700	0.00051359	0.00018822	0.00056744
+GG[C>A]GA	0.00007890	0.00023096	0.00027261	0.00004175	0.00000001	0.00056465	0.00016213
+GG[C>A]GC	0.00005636	0.00018766	0.00003895	0.00000001	0.00000001	0.00000002	0.00008107
+GG[C>A]GG	0.00019162	0.00028870	0.00089571	0.00029225	0.00014007	0.00065876	0.00024319
+GG[C>A]GT	0.00006763	0.00014435	0.00011683	0.00012525	0.00009338	0.00000002	0.00008107
+GG[C>A]TA	0.00081158	0.00051964	0.00089571	0.00070975	0.00051358	0.00282326	0.00064850
+GG[C>A]TC	0.00077776	0.00028869	0.00035049	0.00062625	0.00060696	0.00122341	0.00064850
+GG[C>A]TG	0.00171333	0.00089494	0.00116831	0.00104375	0.00149407	0.00225859	0.00267509
+GG[C>A]TT	0.00136390	0.00089496	0.00155776	0.00108550	0.00084041	0.00122340	0.00129701
+GG[C>G]AA	0.00011272	0.00025983	0.00027261	0.00050100	0.00000001	0.00009411	0.00072957
+GG[C>G]AC	0.00005636	0.00014435	0.00007789	0.00012525	0.00018676	0.00000002	0.00000001
+GG[C>G]AG	0.00022544	0.00030314	0.00007789	0.00008350	0.00028014	0.00000002	0.00000001
+GG[C>G]AT	0.00006763	0.00010104	0.00003895	0.00020875	0.00000001	0.00028234	0.00000001
+GG[C>G]CA	0.00055232	0.00050523	0.00054521	0.00054275	0.00060696	0.00000002	0.00000001
+GG[C>G]CC	0.00022544	0.00011547	0.00007789	0.00033400	0.00000001	0.00037643	0.00072957
+GG[C>G]CG	0.00009018	0.00008661	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GG[C>G]CT	0.00011272	0.00025984	0.00031155	0.00016700	0.00000001	0.00009412	0.00000001
+GG[C>G]GA	0.00000000	0.00002887	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GG[C>G]GC	0.00002254	0.00012992	0.00007789	0.00000001	0.00014007	0.00000002	0.00000002
+GG[C>G]GG	0.00001127	0.00010105	0.00000001	0.00000001	0.00009338	0.00000002	0.00000002
+GG[C>G]GT	0.00000000	0.00004331	0.00019472	0.00000001	0.00014007	0.00000002	0.00000002
+GG[C>G]TA	0.00003382	0.00033201	0.00038944	0.00016700	0.00042021	0.00009412	0.00000001
+GG[C>G]TC	0.00011272	0.00020209	0.00023366	0.00054275	0.00018676	0.00018823	0.00016213
+GG[C>G]TG	0.00021417	0.00028870	0.00042838	0.00045925	0.00018676	0.00084697	0.00064851
+GG[C>G]TT	0.00005636	0.00023096	0.00031155	0.00045925	0.00028014	0.00028232	0.00024319
+GG[C>T]AA	0.00324632	0.00072170	0.00035049	0.00087675	0.00140068	0.00178806	0.00040530
+GG[C>T]AC	0.00285180	0.00040412	0.00101254	0.00100200	0.00060695	0.00112929	0.00097275
+GG[C>T]AG	0.00459895	0.00088046	0.00109043	0.00050099	0.00074701	0.00131750	0.00137807
+GG[C>T]AT	0.00396772	0.00098151	0.00128515	0.00137775	0.00093378	0.00197627	0.00081062
+GG[C>T]CA	0.00671807	0.00105364	0.00128514	0.00129425	0.00154073	0.00254091	0.00137806
+GG[C>T]CC	0.00187114	0.00060624	0.00116832	0.00054275	0.00042020	0.00075286	0.00081063
+GG[C>T]CG	0.00143154	0.00041860	0.00038944	0.00012525	0.00028013	0.00000001	0.00000001
+GG[C>T]CT	0.00349430	0.00059177	0.00151881	0.00075150	0.00084040	0.00084696	0.00064850
+GG[C>T]GA	0.00437351	0.00119802	0.00218086	0.00271377	0.00228778	0.00395254	0.00226976
+GG[C>T]GC	0.00853285	0.00161656	0.00260923	0.00250500	0.00443549	0.00498772	0.00348571
+GG[C>T]GG	0.01035890	0.00274246	0.00436171	0.00613729	0.00457555	0.00715218	0.00794420
+GG[C>T]GT	0.00821724	0.00088036	0.00295973	0.00183700	0.00373514	0.00630525	0.00186444
+GG[C>T]TA	0.00195004	0.00049076	0.00089571	0.00012524	0.00093379	0.00056465	0.00000001
+GG[C>T]TC	0.00138645	0.00050521	0.00128515	0.00062625	0.00102717	0.00112930	0.00072956
+GG[C>T]TG	0.00420443	0.00064949	0.00167459	0.00070975	0.00121391	0.00150571	0.00194551
+GG[C>T]TT	0.00139772	0.00086609	0.00109043	0.00154476	0.00098048	0.00122341	0.00032424
+GG[T>A]AA	0.00000000	0.00012992	0.00035050	0.00033400	0.00051359	0.00037643	0.00000001
+GG[T>A]AC	0.00000000	0.00010105	0.00000001	0.00008350	0.00009338	0.00000002	0.00000002
+GG[T>A]AG	0.00000000	0.00018766	0.00000001	0.00016700	0.00014007	0.00000002	0.00000001
+GG[T>A]AT	0.00007890	0.00020209	0.00023366	0.00004175	0.00000001	0.00009412	0.00000001
+GG[T>A]CA	0.00002254	0.00015879	0.00035050	0.00012525	0.00018676	0.00018822	0.00000001
+GG[T>A]CC	0.00012399	0.00011548	0.00011683	0.00000001	0.00009338	0.00000002	0.00000002
+GG[T>A]CG	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00032425
+GG[T>A]CT	0.00005636	0.00017322	0.00019472	0.00029225	0.00042021	0.00009412	0.00008107
+GG[T>A]GA	0.00001127	0.00033201	0.00027261	0.00041750	0.00014007	0.00056465	0.00000001
+GG[T>A]GC	0.00000000	0.00012992	0.00019472	0.00000001	0.00000001	0.00037644	0.00000001
+GG[T>A]GG	0.00009018	0.00027427	0.00023366	0.00033400	0.00000001	0.00009412	0.00024319
+GG[T>A]GT	0.00002254	0.00025984	0.00031155	0.00004175	0.00004669	0.00009412	0.00000001
+GG[T>A]TA	0.00012399	0.00040419	0.00027261	0.00004175	0.00014007	0.00009412	0.00000001
+GG[T>A]TC	0.00005636	0.00036088	0.00031155	0.00000000	0.00014007	0.00000002	0.00000001
+GG[T>A]TG	0.00018035	0.00020209	0.00007789	0.00029225	0.00042021	0.00000002	0.00000001
+GG[T>A]TT	0.00016908	0.00073620	0.00054521	0.00029225	0.00102717	0.00000002	0.00016212
+GG[T>C]AA	0.00080031	0.00051965	0.00058416	0.00025050	0.00037351	0.00047054	0.00008107
+GG[T>C]AC	0.00087921	0.00028869	0.00038944	0.00054275	0.00060696	0.00037643	0.00024319
+GG[T>C]AG	0.00084539	0.00053409	0.00054521	0.00045925	0.00018675	0.00075286	0.00081063
+GG[T>C]AT	0.00118355	0.00050521	0.00042838	0.00079325	0.00051358	0.00018822	0.00056744
+GG[T>C]CA	0.00112719	0.00033199	0.00038944	0.00033400	0.00060696	0.00094108	0.00048638
+GG[T>C]CC	0.00071013	0.00007216	0.00015578	0.00025050	0.00009338	0.00009411	0.00089170
+GG[T>C]CG	0.00005636	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GG[T>C]CT	0.00038325	0.00017321	0.00046733	0.00033400	0.00028014	0.00047054	0.00064851
+GG[T>C]GA	0.00188241	0.00033197	0.00058416	0.00058450	0.00042020	0.00047054	0.00024318
+GG[T>C]GC	0.00056360	0.00020208	0.00035050	0.00016700	0.00009338	0.00000002	0.00000001
+GG[T>C]GG	0.00128500	0.00041860	0.00058416	0.00066800	0.00074703	0.00028233	0.00032425
+GG[T>C]GT	0.00064250	0.00046192	0.00011683	0.00050100	0.00028013	0.00037643	0.00024319
+GG[T>C]TA	0.00038325	0.00024539	0.00007788	0.00066801	0.00042021	0.00009412	0.00000001
+GG[T>C]TC	0.00055232	0.00021652	0.00031155	0.00075151	0.00037352	0.00075287	0.00000001
+GG[T>C]TG	0.00071013	0.00041861	0.00038944	0.00054275	0.00088710	0.00075287	0.00040531
+GG[T>C]TT	0.00071013	0.00060626	0.00077888	0.00146126	0.00051358	0.00188217	0.00081063
+GG[T>G]AA	0.00004509	0.00018766	0.00011683	0.00033400	0.00023345	0.00000002	0.00000001
+GG[T>G]AC	0.00000000	0.00004331	0.00000001	0.00008350	0.00023345	0.00000002	0.00000002
+GG[T>G]AG	0.00000000	0.00008661	0.00000001	0.00020875	0.00023345	0.00000002	0.00000002
+GG[T>G]AT	0.00003382	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GG[T>G]CA	0.00000000	0.00017323	0.00027261	0.00016700	0.00000001	0.00000002	0.00000001
+GG[T>G]CC	0.00005636	0.00007218	0.00000001	0.00000001	0.00009338	0.00000002	0.00000002
+GG[T>G]CG	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GG[T>G]CT	0.00007890	0.00010105	0.00007789	0.00000001	0.00000001	0.00000002	0.00000002
+GG[T>G]GA	0.00003382	0.00014435	0.00000001	0.00037575	0.00000001	0.00000002	0.00000001
+GG[T>G]GC	0.00006763	0.00004330	0.00000001	0.00004175	0.00000001	0.00000002	0.00024320
+GG[T>G]GG	0.00002254	0.00012992	0.00011683	0.00008350	0.00018676	0.00000002	0.00000001
+GG[T>G]GT	0.00003382	0.00007218	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GG[T>G]TA	0.00001127	0.00002887	0.00027261	0.00025050	0.00032683	0.00000002	0.00000001
+GG[T>G]TC	0.00003382	0.00018766	0.00000001	0.00020875	0.00000001	0.00000002	0.00008107
+GG[T>G]TG	0.00013526	0.00007217	0.00000001	0.00008350	0.00037352	0.00028233	0.00000002
+GG[T>G]TT	0.00104829	0.00066400	0.00062310	0.00033400	0.00116724	0.00094108	0.00048638
+GT[C>A]AA	0.00024798	0.00096717	0.00019471	0.00025049	0.00070035	0.00018822	0.00016212
+GT[C>A]AC	0.00012399	0.00036088	0.00109043	0.00016700	0.00028014	0.00018821	0.00113489
+GT[C>A]AG	0.00020289	0.00038975	0.00031155	0.00062625	0.00060697	0.00075286	0.00081063
+GT[C>A]AT	0.00019162	0.00080837	0.00077887	0.00045925	0.00107386	0.00197628	0.00081063
+GT[C>A]CA	0.00071013	0.00062070	0.00097360	0.00058450	0.00065365	0.00028233	0.00064850
+GT[C>A]CC	0.00018035	0.00060628	0.00023366	0.00050100	0.00009338	0.00075287	0.00000001
+GT[C>A]CG	0.00004509	0.00000000	0.00000001	0.00000001	0.00000001	0.00018823	0.00000002
+GT[C>A]CT	0.00029307	0.00122700	0.00054521	0.00062625	0.00046690	0.00084697	0.00072956
+GT[C>A]GA	0.00003382	0.00004330	0.00003895	0.00000001	0.00000001	0.00056465	0.00000002
+GT[C>A]GC	0.00000000	0.00011548	0.00000001	0.00000001	0.00028014	0.00000002	0.00000002
+GT[C>A]GG	0.00001127	0.00000000	0.00011683	0.00012525	0.00014007	0.00000002	0.00000002
+GT[C>A]GT	0.00002254	0.00000000	0.00042839	0.00000001	0.00000001	0.00028233	0.00000001
+GT[C>A]TA	0.00034943	0.00064957	0.00050627	0.00016700	0.00046690	0.00197628	0.00016212
+GT[C>A]TC	0.00125118	0.00070730	0.00124621	0.00025049	0.00084041	0.00159984	0.00064850
+GT[C>A]TG	0.00099193	0.00054852	0.00085677	0.00062625	0.00051358	0.00150574	0.00032425
+GT[C>A]TT	0.00144281	0.00119808	0.00183036	0.00129425	0.00112055	0.00244681	0.00218871
+GT[C>G]AA	0.00025925	0.00352223	0.00144091	0.00212924	0.00032683	0.00103518	0.00178338
+GT[C>G]AC	0.00011272	0.00077951	0.00027260	0.00050100	0.00023345	0.00009412	0.00016212
+GT[C>G]AG	0.00016908	0.00183329	0.00042837	0.00196226	0.00042021	0.00037644	0.00113488
+GT[C>G]AT	0.00001127	0.00128475	0.00042838	0.00087675	0.00037352	0.00065876	0.00000001
+GT[C>G]CA	0.00006763	0.00142910	0.00042837	0.00041749	0.00042021	0.00056465	0.00016212
+GT[C>G]CC	0.00005636	0.00043306	0.00027261	0.00058450	0.00023345	0.00037643	0.00016212
+GT[C>G]CG	0.00000000	0.00007218	0.00007789	0.00012525	0.00000001	0.00000002	0.00000001
+GT[C>G]CT	0.00004509	0.00090943	0.00000000	0.00054275	0.00018676	0.00000002	0.00024319
+GT[C>G]GA	0.00000000	0.00010105	0.00000001	0.00016701	0.00000001	0.00000002	0.00000002
+GT[C>G]GC	0.00002254	0.00004331	0.00007789	0.00000001	0.00000001	0.00000002	0.00000002
+GT[C>G]GG	0.00000000	0.00007218	0.00000001	0.00008350	0.00009338	0.00000002	0.00000002
+GT[C>G]GT	0.00000000	0.00010105	0.00000001	0.00008350	0.00009338	0.00000002	0.00000002
+GT[C>G]TA	0.00013526	0.00246845	0.00221980	0.00141949	0.00046690	0.00028232	0.00089168
+GT[C>G]TC	0.00031561	0.00222304	0.00101253	0.00183700	0.00042021	0.00075286	0.00056743
+GT[C>G]TG	0.00016908	0.00228079	0.00070098	0.00167000	0.00084042	0.00047054	0.00048636
+GT[C>G]TT	0.00045087	0.00396973	0.00257028	0.00208749	0.00102717	0.00056464	0.00170231
+GT[C>T]AA	0.00054105	0.00178997	0.00237558	0.00162825	0.00154076	0.00094107	0.00145913
+GT[C>T]AC	0.00052978	0.00163119	0.00179142	0.00079324	0.00079372	0.00000001	0.00089169
+GT[C>T]AG	0.00086794	0.00194875	0.00183036	0.00192050	0.00107386	0.00103517	0.00275615
+GT[C>T]AT	0.00063123	0.00243955	0.00229768	0.00112724	0.00149407	0.00094106	0.00356679
+GT[C>T]CA	0.00072140	0.00079393	0.00101254	0.00125251	0.00074703	0.00056465	0.00024318
+GT[C>T]CC	0.00037197	0.00083724	0.00093465	0.00045925	0.00060696	0.00018820	0.00178339
+GT[C>T]CG	0.00003382	0.00010105	0.00003895	0.00041750	0.00000001	0.00000002	0.00016213
+GT[C>T]CT	0.00041706	0.00103933	0.00128515	0.00050100	0.00056028	0.00112930	0.00113488
+GT[C>T]GA	0.00040579	0.00051966	0.00023366	0.00075150	0.00074703	0.00037643	0.00081063
+GT[C>T]GC	0.00080031	0.00041860	0.00031155	0.00016700	0.00074703	0.00084697	0.00097276
+GT[C>T]GG	0.00093557	0.00053408	0.00112937	0.00192052	0.00116724	0.00169394	0.00251297
+GT[C>T]GT	0.00056360	0.00023095	0.00081782	0.00054275	0.00037352	0.00112929	0.00137808
+GT[C>T]TA	0.00047342	0.00108264	0.00081782	0.00045924	0.00107386	0.00141163	0.00032425
+GT[C>T]TC	0.00050723	0.00150125	0.00179142	0.00125250	0.00093379	0.00122338	0.00389105
+GT[C>T]TG	0.00081158	0.00160231	0.00151881	0.00171176	0.00126062	0.00112929	0.00137807
+GT[C>T]TT	0.00054105	0.00197762	0.00190825	0.00108550	0.00116724	0.00141161	0.00186445
+GT[T>A]AA	0.00012399	0.00012992	0.00015578	0.00037575	0.00014007	0.00000002	0.00000001
+GT[T>A]AC	0.00000000	0.00023096	0.00027261	0.00025050	0.00014007	0.00094109	0.00016213
+GT[T>A]AG	0.00000000	0.00005774	0.00007789	0.00029225	0.00023345	0.00009412	0.00024320
+GT[T>A]AT	0.00009018	0.00033201	0.00019472	0.00037575	0.00014007	0.00000002	0.00000001
+GT[T>A]CA	0.00004509	0.00018766	0.00011683	0.00004175	0.00000001	0.00018823	0.00000001
+GT[T>A]CC	0.00007890	0.00031758	0.00015577	0.00008350	0.00000001	0.00000002	0.00000001
+GT[T>A]CG	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GT[T>A]CT	0.00005636	0.00025983	0.00031155	0.00004175	0.00023345	0.00018823	0.00008107
+GT[T>A]GA	0.00000000	0.00025983	0.00000001	0.00033400	0.00000001	0.00028233	0.00032425
+GT[T>A]GC	0.00001127	0.00012992	0.00031155	0.00004175	0.00000001	0.00000002	0.00000001
+GT[T>A]GG	0.00004509	0.00024540	0.00011683	0.00016700	0.00009338	0.00009412	0.00000001
+GT[T>A]GT	0.00002254	0.00001444	0.00007789	0.00020875	0.00004669	0.00009412	0.00000002
+GT[T>A]TA	0.00012399	0.00012992	0.00019472	0.00020875	0.00014007	0.00009412	0.00000001
+GT[T>A]TC	0.00000000	0.00012992	0.00015578	0.00008350	0.00018676	0.00000002	0.00040532
+GT[T>A]TG	0.00010145	0.00024540	0.00023366	0.00033400	0.00065366	0.00000002	0.00000001
+GT[T>A]TT	0.00014653	0.00099604	0.00038943	0.00091850	0.00060697	0.00009411	0.00040531
+GT[T>C]AA	0.00023671	0.00030314	0.00015577	0.00058450	0.00042021	0.00084698	0.00048638
+GT[T>C]AC	0.00038325	0.00005773	0.00050627	0.00016700	0.00023345	0.00000002	0.00008107
+GT[T>C]AG	0.00043961	0.00027426	0.00023366	0.00004175	0.00046690	0.00000002	0.00032426
+GT[T>C]AT	0.00074395	0.00034643	0.00031155	0.00025050	0.00107386	0.00018822	0.00000001
+GT[T>C]CA	0.00020289	0.00025983	0.00027261	0.00037575	0.00014007	0.00037643	0.00000001
+GT[T>C]CC	0.00040579	0.00005773	0.00023366	0.00004175	0.00056028	0.00028232	0.00024319
+GT[T>C]CG	0.00000000	0.00000000	0.00000001	0.00004175	0.00000001	0.00000002	0.00000002
+GT[T>C]CT	0.00013526	0.00028870	0.00062310	0.00062625	0.00065366	0.00028232	0.00040531
+GT[T>C]GA	0.00099193	0.00030312	0.00042838	0.00062625	0.00028013	0.00000001	0.00032425
+GT[T>C]GC	0.00013526	0.00017322	0.00062311	0.00008350	0.00000001	0.00018821	0.00024319
+GT[T>C]GG	0.00032689	0.00014434	0.00031155	0.00008350	0.00000001	0.00009411	0.00064851
+GT[T>C]GT	0.00045088	0.00010104	0.00062311	0.00004175	0.00000001	0.00018822	0.00000001
+GT[T>C]TA	0.00022544	0.00008661	0.00023366	0.00020876	0.00056028	0.00000002	0.00016213
+GT[T>C]TC	0.00014653	0.00010104	0.00000001	0.00029225	0.00014007	0.00065876	0.00000001
+GT[T>C]TG	0.00028180	0.00027426	0.00019472	0.00050100	0.00014007	0.00028232	0.00024320
+GT[T>C]TT	0.00052978	0.00034644	0.00066205	0.00062625	0.00028014	0.00000001	0.00048638
+GT[T>G]AA	0.00006763	0.00011548	0.00007789	0.00004175	0.00023345	0.00084698	0.00000002
+GT[T>G]AC	0.00000000	0.00014435	0.00007789	0.00004175	0.00009338	0.00000002	0.00000002
+GT[T>G]AG	0.00002254	0.00014435	0.00000001	0.00004175	0.00023345	0.00028233	0.00000002
+GT[T>G]AT	0.00003382	0.00017322	0.00023366	0.00033400	0.00000001	0.00009412	0.00032425
+GT[T>G]CA	0.00002254	0.00043306	0.00000000	0.00000000	0.00028014	0.00000002	0.00000001
+GT[T>G]CC	0.00003382	0.00002887	0.00003895	0.00012526	0.00000001	0.00000002	0.00000002
+GT[T>G]CG	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+GT[T>G]CT	0.00009018	0.00008661	0.00027261	0.00012526	0.00009338	0.00000002	0.00000002
+GT[T>G]GA	0.00002254	0.00012991	0.00019472	0.00020875	0.00000001	0.00000001	0.00072957
+GT[T>G]GC	0.00001127	0.00007218	0.00007789	0.00033400	0.00018676	0.00009412	0.00000001
+GT[T>G]GG	0.00000000	0.00012992	0.00007789	0.00000001	0.00018676	0.00018822	0.00000002
+GT[T>G]GT	0.00007890	0.00028870	0.00031155	0.00004175	0.00028014	0.00037643	0.00032425
+GT[T>G]TA	0.00010145	0.00015878	0.00023366	0.00004175	0.00074704	0.00000001	0.00056745
+GT[T>G]TC	0.00033816	0.00024540	0.00000001	0.00004175	0.00000001	0.00000002	0.00000001
+GT[T>G]TG	0.00006763	0.00018766	0.00050627	0.00008350	0.00046690	0.00037643	0.00008107
+GT[T>G]TT	0.00032689	0.00057741	0.00023366	0.00045925	0.00121393	0.00018822	0.00000001
+TA[C>A]AA	0.00031561	0.00135690	0.00190825	0.00112725	0.00172752	0.00291736	0.00170232
+TA[C>A]AC	0.00009017	0.00043306	0.00050627	0.00033400	0.00004669	0.00028233	0.00105383
+TA[C>A]AG	0.00030434	0.00075063	0.00097360	0.00058450	0.00116724	0.00159984	0.00105382
+TA[C>A]AT	0.00046215	0.00069288	0.00112937	0.00054275	0.00088710	0.00103519	0.00064850
+TA[C>A]CA	0.00032689	0.00077950	0.00050627	0.00083500	0.00060697	0.00037643	0.00040531
+TA[C>A]CC	0.00009017	0.00028870	0.00073994	0.00045925	0.00056028	0.00028232	0.00097276
+TA[C>A]CG	0.00006763	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+TA[C>A]CT	0.00018035	0.00050523	0.00101254	0.00012525	0.00065366	0.00037643	0.00008107
+TA[C>A]GA	0.00000000	0.00020209	0.00023367	0.00000001	0.00000001	0.00000002	0.00024319
+TA[C>A]GC	0.00002254	0.00000000	0.00011683	0.00000001	0.00009338	0.00000002	0.00000002
+TA[C>A]GG	0.00000000	0.00014435	0.00007789	0.00000001	0.00014007	0.00000002	0.00000002
+TA[C>A]GT	0.00000000	0.00011548	0.00023366	0.00004175	0.00009338	0.00000002	0.00000001
+TA[C>A]TA	0.00059741	0.00059184	0.00101254	0.00041750	0.00070034	0.00075287	0.00016213
+TA[C>A]TC	0.00050724	0.00024539	0.00066205	0.00025050	0.00000001	0.00000002	0.00008107
+TA[C>A]TG	0.00080031	0.00062071	0.00058416	0.00045925	0.00014007	0.00028232	0.00000001
+TA[C>A]TT	0.00082285	0.00070731	0.00120726	0.00041750	0.00121393	0.00075286	0.00097276
+TA[C>G]AA	0.00011272	0.00037531	0.00109043	0.00075151	0.00056028	0.00047054	0.00016213
+TA[C>G]AC	0.00000000	0.00015879	0.00035050	0.00004175	0.00028014	0.00000002	0.00024319
+TA[C>G]AG	0.00005636	0.00034645	0.00035049	0.00070976	0.00074704	0.00028232	0.00016213
+TA[C>G]AT	0.00010145	0.00033201	0.00038944	0.00016700	0.00023345	0.00028233	0.00000001
+TA[C>G]CA	0.00013526	0.00056298	0.00073993	0.00025050	0.00018676	0.00047054	0.00000001
+TA[C>G]CC	0.00001127	0.00011548	0.00031155	0.00029225	0.00023345	0.00000001	0.00056744
+TA[C>G]CG	0.00000000	0.00004331	0.00003895	0.00004175	0.00000001	0.00000002	0.00000002
+TA[C>G]CT	0.00004509	0.00041862	0.00054521	0.00000000	0.00032683	0.00018822	0.00024319
+TA[C>G]GA	0.00000000	0.00015879	0.00019472	0.00000001	0.00014007	0.00000002	0.00040532
+TA[C>G]GC	0.00000000	0.00007218	0.00011683	0.00000001	0.00000001	0.00000002	0.00000002
+TA[C>G]GG	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00009412	0.00008107
+TA[C>G]GT	0.00000000	0.00010105	0.00000001	0.00041750	0.00009338	0.00028233	0.00000001
+TA[C>G]TA	0.00011272	0.00024540	0.00050627	0.00075151	0.00046690	0.00000001	0.00072957
+TA[C>G]TC	0.00000000	0.00028871	0.00054522	0.00054275	0.00051359	0.00028232	0.00024319
+TA[C>G]TG	0.00033816	0.00028870	0.00027261	0.00037575	0.00032683	0.00028233	0.00000001
+TA[C>G]TT	0.00005636	0.00059185	0.00093465	0.00096026	0.00074704	0.00037643	0.00032425
+TA[C>T]AA	0.00130754	0.00064956	0.00035049	0.00083500	0.00084041	0.00094108	0.00048637
+TA[C>T]AC	0.00260382	0.00036082	0.00031155	0.00045925	0.00051357	0.00112929	0.00081063
+TA[C>T]AG	0.00219803	0.00067841	0.00050626	0.00079325	0.00107385	0.00103518	0.00097276
+TA[C>T]AT	0.00166824	0.00164559	0.00159669	0.00104375	0.00154075	0.00122340	0.00048637
+TA[C>T]CA	0.00172461	0.00062067	0.00050627	0.00054275	0.00065365	0.00094107	0.00235084
+TA[C>T]CC	0.00065377	0.00040417	0.00058416	0.00033400	0.00042021	0.00075287	0.00040531
+TA[C>T]CG	0.00006763	0.00004330	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+TA[C>T]CT	0.00083412	0.00086609	0.00097360	0.00008350	0.00046689	0.00159984	0.00121595
+TA[C>T]GA	0.00215294	0.00119806	0.00225875	0.00129425	0.00158744	0.00385843	0.00356679
+TA[C>T]GC	0.00269399	0.00127023	0.00202508	0.00175351	0.00266131	0.00348199	0.00413423
+TA[C>T]GG	0.00246855	0.00073613	0.00155775	0.00162826	0.00242786	0.00414076	0.00324254
+TA[C>T]GT	0.00427206	0.00103923	0.00268713	0.00137775	0.00228778	0.00385842	0.00340466
+TA[C>T]TA	0.00073268	0.00051966	0.00070099	0.00058450	0.00046689	0.00056465	0.00040531
+TA[C>T]TC	0.00089048	0.00031756	0.00042838	0.00045925	0.00093379	0.00056465	0.00048638
+TA[C>T]TG	0.00126246	0.00049078	0.00050627	0.00066800	0.00116724	0.00056465	0.00048637
+TA[C>T]TT	0.00060868	0.00080836	0.00070099	0.00087675	0.00084041	0.00112929	0.00259403
+TA[T>A]AA	0.00021417	0.00080837	0.00054521	0.00108551	0.00140069	0.00084698	0.00024318
+TA[T>A]AC	0.00009018	0.00036088	0.00015577	0.00033400	0.00009338	0.00000002	0.00024319
+TA[T>A]AG	0.00007890	0.00015878	0.00019472	0.00000001	0.00009338	0.00075287	0.00040532
+TA[T>A]AT	0.00018035	0.00054854	0.00050627	0.00045925	0.00060697	0.00056466	0.00032425
+TA[T>A]CA	0.00051851	0.00034644	0.00058416	0.00008350	0.00037352	0.00018822	0.00000001
+TA[T>A]CC	0.00011272	0.00021653	0.00070099	0.00050100	0.00032683	0.00018822	0.00040531
+TA[T>A]CG	0.00000000	0.00010105	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+TA[T>A]CT	0.00030434	0.00051967	0.00050627	0.00037575	0.00056028	0.00056465	0.00008107
+TA[T>A]GA	0.00018035	0.00038974	0.00042838	0.00058450	0.00014007	0.00065876	0.00056744
+TA[T>A]GC	0.00005636	0.00024540	0.00023366	0.00025050	0.00004669	0.00028234	0.00000001
+TA[T>A]GG	0.00007890	0.00011548	0.00035050	0.00012525	0.00023345	0.00018823	0.00016213
+TA[T>A]GT	0.00000000	0.00049080	0.00140199	0.00041750	0.00028014	0.00000001	0.00064850
+TA[T>A]TA	0.00050724	0.00036087	0.00027260	0.00054275	0.00046690	0.00103519	0.00024320
+TA[T>A]TC	0.00020289	0.00012991	0.00035050	0.00000001	0.00046690	0.00018823	0.00000001
+TA[T>A]TG	0.00046215	0.00034644	0.00011683	0.00041750	0.00018676	0.00037643	0.00040532
+TA[T>A]TT	0.00090175	0.00051965	0.00159670	0.00054275	0.00112055	0.00056464	0.00089169
+TA[T>C]AA	0.00057487	0.00148682	0.00089570	0.00116900	0.00149407	0.00122339	0.00243190
+TA[T>C]AC	0.00086794	0.00057739	0.00054521	0.00087675	0.00093379	0.00122340	0.00145914
+TA[T>C]AG	0.00078903	0.00111149	0.00081782	0.00121075	0.00065365	0.00254092	0.00154020
+TA[T>C]AT	0.00119482	0.00167447	0.00124619	0.00183701	0.00210104	0.00094105	0.00421530
+TA[T>C]CA	0.00073268	0.00050522	0.00046732	0.00033400	0.00037351	0.00009411	0.00024318
+TA[T>C]CC	0.00038324	0.00056297	0.00093466	0.00041750	0.00023345	0.00112930	0.00016213
+TA[T>C]CG	0.00002254	0.00000000	0.00011683	0.00000001	0.00000001	0.00000002	0.00000002
+TA[T>C]CT	0.00042833	0.00092385	0.00097360	0.00025049	0.00037352	0.00084698	0.00024318
+TA[T>C]GA	0.00135263	0.00047633	0.00046732	0.00041750	0.00060696	0.00159984	0.00056744
+TA[T>C]GC	0.00022544	0.00033201	0.00058416	0.00100201	0.00046690	0.00037643	0.00072957
+TA[T>C]GG	0.00091303	0.00075061	0.00035049	0.00054275	0.00051358	0.00122341	0.00056744
+TA[T>C]GT	0.00059741	0.00082280	0.00058415	0.00075150	0.00093379	0.00075287	0.00040531
+TA[T>C]TA	0.00046215	0.00101046	0.00116832	0.00133601	0.00070034	0.00150573	0.00129701
+TA[T>C]TC	0.00025925	0.00046192	0.00105149	0.00079326	0.00042021	0.00047054	0.00121595
+TA[T>C]TG	0.00075522	0.00066400	0.00081782	0.00041750	0.00102717	0.00188217	0.00113489
+TA[T>C]TT	0.00071013	0.00184770	0.00147986	0.00196226	0.00326828	0.00094105	0.00526913
+TA[T>G]AA	0.00015781	0.00036088	0.00011683	0.00029225	0.00116724	0.00056465	0.00024319
+TA[T>G]AC	0.00000000	0.00004331	0.00000001	0.00000001	0.00009338	0.00000002	0.00000002
+TA[T>G]AG	0.00014653	0.00021653	0.00077888	0.00037575	0.00000001	0.00037643	0.00000001
+TA[T>G]AT	0.00000000	0.00023097	0.00050627	0.00037575	0.00051359	0.00000002	0.00000001
+TA[T>G]CA	0.00020289	0.00015878	0.00000001	0.00004175	0.00028014	0.00000002	0.00016213
+TA[T>G]CC	0.00002254	0.00010105	0.00023366	0.00000001	0.00018676	0.00037644	0.00048638
+TA[T>G]CG	0.00000000	0.00000000	0.00000001	0.00004175	0.00004669	0.00000002	0.00000002
+TA[T>G]CT	0.00006763	0.00011548	0.00003895	0.00000001	0.00009338	0.00009412	0.00016214
+TA[T>G]GA	0.00018035	0.00014435	0.00046733	0.00016700	0.00037352	0.00018823	0.00000001
+TA[T>G]GC	0.00000000	0.00012992	0.00019472	0.00029225	0.00000001	0.00075287	0.00000001
+TA[T>G]GG	0.00004509	0.00005774	0.00011683	0.00004175	0.00000001	0.00000002	0.00024319
+TA[T>G]GT	0.00006763	0.00025983	0.00003895	0.00020875	0.00000001	0.00075287	0.00000001
+TA[T>G]TA	0.00039452	0.00027426	0.00015577	0.00020875	0.00060697	0.00000002	0.00008107
+TA[T>G]TC	0.00023671	0.00025983	0.00019472	0.00012525	0.00060697	0.00000002	0.00000001
+TA[T>G]TG	0.00021417	0.00025983	0.00007788	0.00000001	0.00074704	0.00018822	0.00000001
+TA[T>G]TT	0.00048469	0.00038974	0.00097360	0.00150301	0.00140069	0.00065875	0.00097276
+TC[C>A]AA	0.00042833	0.00077950	0.00151882	0.00087675	0.00070035	0.00018821	0.00048637
+TC[C>A]AC	0.00060868	0.00036087	0.00081782	0.00037575	0.00014007	0.00178806	0.00008107
+TC[C>A]AG	0.00050724	0.00062071	0.00124621	0.00020875	0.00037352	0.00056465	0.00000001
+TC[C>A]AT	0.00191623	0.00128471	0.00147987	0.00058449	0.00070034	0.00141162	0.00089169
+TC[C>A]CA	0.00420443	0.00165998	0.00062309	0.00079324	0.00060695	0.00075285	0.00072955
+TC[C>A]CC	0.00082285	0.00063514	0.00070099	0.00016699	0.00056027	0.00056465	0.00016213
+TC[C>A]CG	0.00025925	0.00008661	0.00011684	0.00016700	0.00014007	0.00000002	0.00000001
+TC[C>A]CT	0.00187114	0.00073616	0.00054521	0.00091850	0.00037351	0.00159984	0.00016212
+TC[C>A]GA	0.00010145	0.00011548	0.00027261	0.00000001	0.00014007	0.00037643	0.00000001
+TC[C>A]GC	0.00016908	0.00000000	0.00007789	0.00000001	0.00000001	0.00047054	0.00000002
+TC[C>A]GG	0.00011272	0.00018766	0.00000001	0.00000001	0.00000001	0.00000002	0.00008107
+TC[C>A]GT	0.00015781	0.00011548	0.00011683	0.00000001	0.00023345	0.00000002	0.00000001
+TC[C>A]TA	0.00438478	0.00060619	0.00105149	0.00037574	0.00004667	0.00122339	0.00137807
+TC[C>A]TC	0.00574869	0.00063504	0.00042837	0.00104375	0.00135397	0.00056463	0.00097275
+TC[C>A]TG	0.00652645	0.00095259	0.00081781	0.00012523	0.00079369	0.00263502	0.00064849
+TC[C>A]TT	0.00818343	0.00158771	0.00214191	0.00121074	0.00186755	0.00225858	0.00178337
+TC[C>G]AA	0.00003382	0.00053411	0.00101254	0.00058450	0.00018676	0.00000002	0.00024318
+TC[C>G]AC	0.00000000	0.00004331	0.00003895	0.00000001	0.00000001	0.00000002	0.00000002
+TC[C>G]AG	0.00000000	0.00040419	0.00015577	0.00033400	0.00037352	0.00000002	0.00000001
+TC[C>G]AT	0.00000000	0.00031758	0.00015577	0.00012525	0.00028014	0.00000002	0.00008107
+TC[C>G]CA	0.00010145	0.00053411	0.00058416	0.00041750	0.00037352	0.00065876	0.00016213
+TC[C>G]CC	0.00006763	0.00020209	0.00000001	0.00004175	0.00014007	0.00000002	0.00008107
+TC[C>G]CG	0.00000000	0.00000000	0.00011684	0.00016700	0.00004669	0.00009412	0.00000002
+TC[C>G]CT	0.00002254	0.00036088	0.00124621	0.00075151	0.00042021	0.00000001	0.00056744
+TC[C>G]GA	0.00001127	0.00007218	0.00023366	0.00000001	0.00000001	0.00000002	0.00016214
+TC[C>G]GC	0.00004509	0.00004331	0.00000001	0.00050101	0.00000001	0.00000002	0.00000001
+TC[C>G]GG	0.00001127	0.00002887	0.00003895	0.00008350	0.00000001	0.00028234	0.00000002
+TC[C>G]GT	0.00000000	0.00010105	0.00000001	0.00000001	0.00014007	0.00018823	0.00000002
+TC[C>G]TA	0.00000000	0.00088056	0.00042838	0.00058450	0.00018676	0.00018821	0.00056744
+TC[C>G]TC	0.00004509	0.00046193	0.00007788	0.00037575	0.00014007	0.00018822	0.00081064
+TC[C>G]TG	0.00002254	0.00076507	0.00019472	0.00012524	0.00000001	0.00018821	0.00064851
+TC[C>G]TT	0.00001127	0.00069290	0.00042838	0.00096026	0.00009338	0.00037643	0.00024318
+TC[C>T]AA	0.00055232	0.00103933	0.00027260	0.00075150	0.00042021	0.00056464	0.00129701
+TC[C>T]AC	0.00052978	0.00086611	0.00058415	0.00104375	0.00065365	0.00159985	0.00024318
+TC[C>T]AG	0.00096938	0.00115480	0.00175248	0.00062625	0.00074703	0.00084696	0.00154020
+TC[C>T]AT	0.00094684	0.00151569	0.00144092	0.00125250	0.00079372	0.00084697	0.00097275
+TC[C>T]CA	0.00247982	0.00106816	0.00245347	0.00050099	0.00093378	0.00216448	0.00170232
+TC[C>T]CC	0.00077776	0.00082279	0.00101254	0.00045925	0.00112055	0.00122340	0.00194552
+TC[C>T]CG	0.00021417	0.00010104	0.00019472	0.00004175	0.00000001	0.00000002	0.00016213
+TC[C>T]CT	0.00103702	0.00090939	0.00159670	0.00116900	0.00060696	0.00178805	0.00121594
+TC[C>T]GA	0.00241219	0.00037524	0.00101254	0.00150301	0.00135399	0.00338789	0.00243190
+TC[C>T]GC	0.00464403	0.00134238	0.00202507	0.00196225	0.00345502	0.00357610	0.00291827
+TC[C>T]GG	0.00161188	0.00124138	0.00112936	0.00141950	0.00270800	0.00432897	0.00372892
+TC[C>T]GT	0.00338158	0.00057731	0.00128514	0.00196226	0.00270800	0.00432897	0.00308041
+TC[C>T]TA	0.00078903	0.00062070	0.00050627	0.00066800	0.00051358	0.00056464	0.00105382
+TC[C>T]TC	0.00142026	0.00105375	0.00140198	0.00096025	0.00084041	0.00141162	0.00097275
+TC[C>T]TG	0.00162316	0.00086608	0.00155776	0.00091850	0.00056027	0.00169394	0.00170232
+TC[C>T]TT	0.00116101	0.00137133	0.00202508	0.00116900	0.00149407	0.00122340	0.00081062
+TC[T>A]AA	0.00013526	0.00017322	0.00019472	0.00041750	0.00042021	0.00000001	0.00048638
+TC[T>A]AC	0.00000000	0.00030314	0.00011683	0.00037575	0.00042021	0.00018822	0.00016212
+TC[T>A]AG	0.00005636	0.00021653	0.00042838	0.00037575	0.00009338	0.00056465	0.00000001
+TC[T>A]AT	0.00018035	0.00038974	0.00058416	0.00025050	0.00065366	0.00122341	0.00040531
+TC[T>A]CA	0.00059741	0.00046192	0.00035049	0.00041750	0.00070035	0.00075287	0.00008107
+TC[T>A]CC	0.00019162	0.00027427	0.00066205	0.00016700	0.00042021	0.00075287	0.00024319
+TC[T>A]CG	0.00001127	0.00002887	0.00000001	0.00008351	0.00014007	0.00000002	0.00032426
+TC[T>A]CT	0.00019162	0.00073620	0.00085676	0.00012525	0.00070035	0.00018821	0.00089170
+TC[T>A]GA	0.00001127	0.00034645	0.00031155	0.00016700	0.00023345	0.00000002	0.00032425
+TC[T>A]GC	0.00001127	0.00041862	0.00007789	0.00008350	0.00009338	0.00065876	0.00008107
+TC[T>A]GG	0.00003382	0.00037532	0.00058416	0.00029225	0.00070035	0.00018822	0.00040531
+TC[T>A]GT	0.00013526	0.00064959	0.00015577	0.00033400	0.00070035	0.00028232	0.00048638
+TC[T>A]TA	0.00007890	0.00062072	0.00058415	0.00058450	0.00121394	0.00000002	0.00032425
+TC[T>A]TC	0.00006763	0.00034645	0.00066205	0.00075151	0.00065366	0.00018822	0.00032425
+TC[T>A]TG	0.00009017	0.00033201	0.00050627	0.00025050	0.00107387	0.00000002	0.00024319
+TC[T>A]TT	0.00007890	0.00089499	0.00070098	0.00116901	0.00130731	0.00169396	0.00024318
+TC[T>C]AA	0.00048469	0.00044748	0.00089571	0.00066800	0.00065366	0.00047054	0.00081063
+TC[T>C]AC	0.00074395	0.00069288	0.00038944	0.00016699	0.00028013	0.00056465	0.00000001
+TC[T>C]AG	0.00075522	0.00072176	0.00058416	0.00058450	0.00056027	0.00009411	0.00016213
+TC[T>C]AT	0.00073267	0.00077949	0.00062310	0.00079325	0.00149407	0.00056465	0.00064850
+TC[T>C]CA	0.00080031	0.00092385	0.00089570	0.00070975	0.00252124	0.00075287	0.00008106
+TC[T>C]CC	0.00069886	0.00050522	0.00054521	0.00041750	0.00112055	0.00122341	0.00024319
+TC[T>C]CG	0.00012399	0.00007218	0.00027261	0.00012525	0.00004669	0.00000002	0.00000001
+TC[T>C]CT	0.00082285	0.00134247	0.00175247	0.00121075	0.00205435	0.00084696	0.00170232
+TC[T>C]GA	0.00144281	0.00040416	0.00035049	0.00033400	0.00051358	0.00009411	0.00024319
+TC[T>C]GC	0.00059741	0.00063514	0.00046732	0.00050100	0.00056028	0.00084697	0.00081063
+TC[T>C]GG	0.00077776	0.00064957	0.00019471	0.00075150	0.00065365	0.00103519	0.00129701
+TC[T>C]GT	0.00098066	0.00088053	0.00147987	0.00091850	0.00056027	0.00084697	0.00089169
+TC[T>C]TA	0.00031561	0.00044749	0.00042838	0.00083501	0.00158745	0.00018822	0.00032425
+TC[T>C]TC	0.00060868	0.00070732	0.00089571	0.00054275	0.00084041	0.00018821	0.00072957
+TC[T>C]TG	0.00075522	0.00079393	0.00023365	0.00104375	0.00233449	0.00037643	0.00113488
+TC[T>C]TT	0.00195004	0.00155898	0.00190825	0.00250501	0.00200765	0.00047052	0.00170232
+TC[T>G]AA	0.00007890	0.00010104	0.00011683	0.00029225	0.00023345	0.00018823	0.00000001
+TC[T>G]AC	0.00000000	0.00012992	0.00031155	0.00025050	0.00000001	0.00000002	0.00000001
+TC[T>G]AG	0.00002254	0.00010105	0.00000001	0.00000001	0.00009338	0.00000002	0.00008107
+TC[T>G]AT	0.00006763	0.00015879	0.00027261	0.00058451	0.00000001	0.00000002	0.00000001
+TC[T>G]CA	0.00020289	0.00033201	0.00007789	0.00029225	0.00032683	0.00047054	0.00000001
+TC[T>G]CC	0.00028180	0.00005774	0.00019472	0.00020875	0.00028014	0.00000002	0.00024319
+TC[T>G]CG	0.00000000	0.00000000	0.00000001	0.00000001	0.00060697	0.00000002	0.00000002
+TC[T>G]CT	0.00043961	0.00023096	0.00023366	0.00058450	0.00037352	0.00000002	0.00000001
+TC[T>G]GA	0.00041706	0.00064959	0.00093465	0.00033400	0.00051359	0.00000002	0.00000001
+TC[T>G]GC	0.00016908	0.00020209	0.00031155	0.00033400	0.00014007	0.00028233	0.00040532
+TC[T>G]GG	0.00027053	0.00017322	0.00007789	0.00033400	0.00004669	0.00000002	0.00000001
+TC[T>G]GT	0.00028180	0.00049080	0.00027260	0.00025050	0.00032683	0.00065876	0.00000001
+TC[T>G]TA	0.00055232	0.00036087	0.00042837	0.00087676	0.00438884	0.00000001	0.00048638
+TC[T>G]TC	0.00049596	0.00028870	0.00011682	0.00083501	0.00238118	0.00047055	0.00000001
+TC[T>G]TG	0.00040579	0.00030314	0.00031155	0.00000000	0.00158745	0.00000002	0.00000001
+TC[T>G]TT	0.00093557	0.00079392	0.00070098	0.00045925	0.00224111	0.00075287	0.00016212
+TG[C>A]AA	0.00080030	0.00160229	0.00323235	0.00233801	0.00116724	0.00414076	0.00356678
+TG[C>A]AC	0.00027052	0.00067845	0.00073993	0.00100201	0.00098048	0.00094108	0.00064850
+TG[C>A]AG	0.00064250	0.00135690	0.00183036	0.00146125	0.00051358	0.00310557	0.00235083
+TG[C>A]AT	0.00041706	0.00082280	0.00128515	0.00100200	0.00056028	0.00291736	0.00105382
+TG[C>A]CA	0.00058614	0.00060626	0.00109043	0.00075150	0.00079372	0.00188217	0.00097276
+TG[C>A]CC	0.00031561	0.00046193	0.00038944	0.00016700	0.00051359	0.00037643	0.00000001
+TG[C>A]CG	0.00011272	0.00000000	0.00019472	0.00012525	0.00032683	0.00018821	0.00000002
+TG[C>A]CT	0.00059741	0.00076505	0.00105148	0.00112726	0.00102717	0.00131751	0.00137807
+TG[C>A]GA	0.00007890	0.00014435	0.00042838	0.00008350	0.00000001	0.00009411	0.00032425
+TG[C>A]GC	0.00006763	0.00002887	0.00000001	0.00008350	0.00000001	0.00000002	0.00000002
+TG[C>A]GG	0.00016908	0.00007217	0.00035050	0.00000001	0.00023345	0.00009412	0.00032425
+TG[C>A]GT	0.00002254	0.00010105	0.00031155	0.00020876	0.00009338	0.00000002	0.00024320
+TG[C>A]TA	0.00119482	0.00072174	0.00081782	0.00070975	0.00018676	0.00159984	0.00024318
+TG[C>A]TC	0.00104829	0.00050521	0.00054521	0.00083500	0.00042020	0.00131751	0.00097276
+TG[C>A]TG	0.00245728	0.00024535	0.00112938	0.00116901	0.00060696	0.00131751	0.00081062
+TG[C>A]TT	0.00181478	0.00118365	0.00210297	0.00079325	0.00051358	0.00282324	0.00226977
+TG[C>G]AA	0.00016908	0.00056298	0.00019472	0.00050100	0.00028014	0.00000002	0.00008107
+TG[C>G]AC	0.00002254	0.00005774	0.00000001	0.00008350	0.00018676	0.00018822	0.00032425
+TG[C>G]AG	0.00005636	0.00015879	0.00019472	0.00029225	0.00046690	0.00028233	0.00008107
+TG[C>G]AT	0.00001127	0.00014435	0.00062311	0.00045925	0.00014007	0.00009411	0.00056744
+TG[C>G]CA	0.00013526	0.00047636	0.00019472	0.00041750	0.00023345	0.00056465	0.00000001
+TG[C>G]CC	0.00005636	0.00020209	0.00042838	0.00016700	0.00018676	0.00018822	0.00032425
+TG[C>G]CG	0.00002254	0.00004331	0.00023366	0.00000001	0.00000001	0.00000002	0.00000002
+TG[C>G]CT	0.00011272	0.00054854	0.00031155	0.00004175	0.00037352	0.00056465	0.00024319
+TG[C>G]GA	0.00000000	0.00008661	0.00000001	0.00016700	0.00004669	0.00000002	0.00000002
+TG[C>G]GC	0.00000000	0.00001444	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+TG[C>G]GG	0.00000000	0.00002887	0.00007789	0.00000001	0.00000001	0.00000002	0.00000002
+TG[C>G]GT	0.00000000	0.00001444	0.00015578	0.00000001	0.00014007	0.00000002	0.00016213
+TG[C>G]TA	0.00007890	0.00050524	0.00046733	0.00016700	0.00028014	0.00028232	0.00016212
+TG[C>G]TC	0.00003382	0.00028871	0.00007789	0.00020875	0.00051359	0.00037644	0.00000001
+TG[C>G]TG	0.00027053	0.00066403	0.00003894	0.00070975	0.00009338	0.00000002	0.00008107
+TG[C>G]TT	0.00016908	0.00040418	0.00042838	0.00050100	0.00004669	0.00103519	0.00064850
+TG[C>T]AA	0.00386627	0.00082274	0.00155776	0.00171176	0.00107384	0.00094107	0.00121594
+TG[C>T]AC	0.00364084	0.00059177	0.00077887	0.00096025	0.00088709	0.00141162	0.00016212
+TG[C>T]AG	0.00463276	0.00137126	0.00155775	0.00162825	0.00084039	0.00216448	0.00064849
+TG[C>T]AT	0.00553452	0.00092375	0.00097359	0.00096025	0.00088708	0.00197627	0.00048636
+TG[C>T]CA	0.01005457	0.00163098	0.00109042	0.00096023	0.00079367	0.00432896	0.00194550
+TG[C>T]CC	0.00406917	0.00079386	0.00151881	0.00058449	0.00154074	0.00075285	0.00097275
+TG[C>T]CG	0.00084540	0.00015877	0.00011683	0.00041750	0.00009338	0.00009411	0.00024319
+TG[C>T]CT	0.00514000	0.00099593	0.00186930	0.00158650	0.00191426	0.00207037	0.00137806
+TG[C>T]GA	0.00422697	0.00059173	0.00183036	0.00175351	0.00270799	0.00291733	0.00340466
+TG[C>T]GC	0.00536544	0.00093817	0.00323235	0.00208751	0.00303481	0.00517595	0.00226976
+TG[C>T]GG	0.00559088	0.00109695	0.00315445	0.00279727	0.00438881	0.00329376	0.00405316
+TG[C>T]GT	0.00831869	0.00125568	0.00257029	0.00200400	0.00266128	0.00319965	0.00340465
+TG[C>T]TA	0.00253618	0.00056292	0.00085676	0.00070975	0.00098047	0.00075285	0.00154020
+TG[C>T]TC	0.00260382	0.00075058	0.00120726	0.00104375	0.00070033	0.00065875	0.00097275
+TG[C>T]TG	0.00754093	0.00069274	0.00194719	0.00146125	0.00158741	0.00169393	0.00137806
+TG[C>T]TT	0.00316741	0.00122693	0.00245347	0.00091849	0.00177420	0.00291736	0.00089168
+TG[T>A]AA	0.00006763	0.00020209	0.00011683	0.00041750	0.00042021	0.00000002	0.00000001
+TG[T>A]AC	0.00009018	0.00014435	0.00015578	0.00000001	0.00014007	0.00018822	0.00024319
+TG[T>A]AG	0.00005636	0.00040419	0.00038944	0.00020875	0.00018676	0.00028232	0.00032426
+TG[T>A]AT	0.00014653	0.00053411	0.00050627	0.00033400	0.00028014	0.00000001	0.00081063
+TG[T>A]CA	0.00030434	0.00036088	0.00038944	0.00029225	0.00032683	0.00000002	0.00032425
+TG[T>A]CC	0.00043961	0.00031757	0.00035049	0.00008350	0.00014007	0.00056465	0.00032425
+TG[T>A]CG	0.00000000	0.00004331	0.00000001	0.00000001	0.00004669	0.00000002	0.00000002
+TG[T>A]CT	0.00030434	0.00073620	0.00015577	0.00029225	0.00018676	0.00009411	0.00056744
+TG[T>A]GA	0.00027053	0.00025983	0.00046733	0.00033400	0.00037352	0.00028232	0.00008107
+TG[T>A]GC	0.00012399	0.00017322	0.00023366	0.00008350	0.00009338	0.00018821	0.00032426
+TG[T>A]GG	0.00010145	0.00020209	0.00015577	0.00020875	0.00004669	0.00028233	0.00016213
+TG[T>A]GT	0.00010145	0.00034645	0.00058416	0.00037575	0.00028014	0.00065876	0.00000001
+TG[T>A]TA	0.00039452	0.00054854	0.00070099	0.00058450	0.00018676	0.00018822	0.00024319
+TG[T>A]TC	0.00034943	0.00010104	0.00007789	0.00033400	0.00028014	0.00000002	0.00040532
+TG[T>A]TG	0.00033816	0.00028870	0.00007789	0.00025050	0.00070035	0.00037643	0.00000001
+TG[T>A]TT	0.00032688	0.00060628	0.00070099	0.00125251	0.00042021	0.00018822	0.00064850
+TG[T>C]AA	0.00178096	0.00114036	0.00183036	0.00137775	0.00280138	0.00065875	0.00024318
+TG[T>C]AC	0.00163443	0.00051963	0.00058416	0.00104376	0.00046689	0.00094108	0.00105382
+TG[T>C]AG	0.00147662	0.00131359	0.00023365	0.00162826	0.00056027	0.00103519	0.00081062
+TG[T>C]AT	0.00264890	0.00131356	0.00128514	0.00167000	0.00196096	0.00103518	0.00097275
+TG[T>C]CA	0.00182605	0.00060624	0.00058415	0.00037575	0.00112055	0.00047053	0.00121595
+TG[T>C]CC	0.00095811	0.00041861	0.00066204	0.00091851	0.00102717	0.00047054	0.00040532
+TG[T>C]CG	0.00018035	0.00008661	0.00011683	0.00025050	0.00009338	0.00000002	0.00024319
+TG[T>C]CT	0.00096939	0.00128473	0.00085676	0.00083500	0.00070034	0.00056464	0.00105381
+TG[T>C]GA	0.00167952	0.00063512	0.00085677	0.00075150	0.00014006	0.00094108	0.00040531
+TG[T>C]GC	0.00113846	0.00049077	0.00120726	0.00016700	0.00060696	0.00112930	0.00072957
+TG[T>C]GG	0.00116101	0.00057738	0.00112937	0.00029225	0.00112055	0.00122341	0.00032425
+TG[T>C]GT	0.00089048	0.00069287	0.00163565	0.00075150	0.00088710	0.00122341	0.00048637
+TG[T>C]TA	0.00068759	0.00135691	0.00031154	0.00150300	0.00107386	0.00084697	0.00032424
+TG[T>C]TC	0.00083412	0.00064957	0.00105148	0.00167001	0.00116724	0.00141162	0.00089169
+TG[T>C]TG	0.00084539	0.00112593	0.00109042	0.00175351	0.00149407	0.00178806	0.00048637
+TG[T>C]TT	0.00174715	0.00177551	0.00210297	0.00258851	0.00224110	0.00254093	0.00089168
+TG[T>G]AA	0.00005636	0.00025983	0.00042838	0.00041750	0.00018676	0.00028233	0.00000001
+TG[T>G]AC	0.00000000	0.00000000	0.00007789	0.00000001	0.00014007	0.00009412	0.00000002
+TG[T>G]AG	0.00001127	0.00001444	0.00015578	0.00020876	0.00000001	0.00000002	0.00008107
+TG[T>G]AT	0.00000000	0.00014435	0.00000001	0.00033400	0.00023345	0.00000002	0.00024319
+TG[T>G]CA	0.00010145	0.00007217	0.00003895	0.00033400	0.00018676	0.00000002	0.00008107
+TG[T>G]CC	0.00009018	0.00010105	0.00000001	0.00008350	0.00023345	0.00000002	0.00040532
+TG[T>G]CG	0.00000000	0.00000000	0.00000001	0.00000001	0.00000001	0.00000002	0.00016213
+TG[T>G]CT	0.00013526	0.00015879	0.00011683	0.00008350	0.00018676	0.00028233	0.00000001
+TG[T>G]GA	0.00005636	0.00036088	0.00027261	0.00070976	0.00028014	0.00000002	0.00000001
+TG[T>G]GC	0.00003382	0.00025984	0.00011683	0.00008350	0.00000001	0.00000002	0.00000001
+TG[T>G]GG	0.00004509	0.00002887	0.00007789	0.00029225	0.00014007	0.00000002	0.00000001
+TG[T>G]GT	0.00022544	0.00021653	0.00019472	0.00012525	0.00037352	0.00000002	0.00000001
+TG[T>G]TA	0.00023671	0.00034644	0.00019472	0.00079326	0.00093379	0.00009412	0.00032425
+TG[T>G]TC	0.00016908	0.00017322	0.00011683	0.00041750	0.00004669	0.00000002	0.00016213
+TG[T>G]TG	0.00010145	0.00015879	0.00003894	0.00025050	0.00065366	0.00037644	0.00000001
+TG[T>G]TT	0.00058614	0.00049079	0.00058416	0.00025050	0.00102717	0.00037643	0.00048638
+TT[C>A]AA	0.00050723	0.00186214	0.00233663	0.00171175	0.00098048	0.00423488	0.00129700
+TT[C>A]AC	0.00028180	0.00141466	0.00132409	0.00125250	0.00032683	0.00056465	0.00072956
+TT[C>A]AG	0.00033816	0.00167449	0.00206403	0.00116900	0.00084041	0.00235271	0.00056743
+TT[C>A]AT	0.00077776	0.00238180	0.00319340	0.00350702	0.00177421	0.00282324	0.00308040
+TT[C>A]CA	0.00086794	0.00193431	0.00186930	0.00141950	0.00070034	0.00235270	0.00243189
+TT[C>A]CC	0.00032688	0.00145796	0.00089570	0.00121075	0.00084042	0.00065875	0.00194552
+TT[C>A]CG	0.00005636	0.00014435	0.00015578	0.00004175	0.00000001	0.00000002	0.00000001
+TT[C>A]CT	0.00049596	0.00203537	0.00253135	0.00091849	0.00121393	0.00244682	0.00113487
+TT[C>A]GA	0.00005636	0.00014435	0.00003895	0.00050100	0.00023345	0.00065876	0.00000001
+TT[C>A]GC	0.00002254	0.00018766	0.00003895	0.00000001	0.00028014	0.00018822	0.00008107
+TT[C>A]GG	0.00005636	0.00018766	0.00015578	0.00020875	0.00009338	0.00018823	0.00016213
+TT[C>A]GT	0.00000000	0.00020210	0.00015577	0.00045925	0.00009338	0.00000002	0.00016213
+TT[C>A]TA	0.00130754	0.00153011	0.00272608	0.00175351	0.00205435	0.00263503	0.00154019
+TT[C>A]TC	0.00213039	0.00166001	0.00221980	0.00125250	0.00275469	0.00395254	0.00259402
+TT[C>A]TG	0.00220929	0.00271378	0.00264818	0.00196224	0.00191427	0.00508185	0.00308040
+TT[C>A]TT	0.00302087	0.00461921	0.00704885	0.00354875	0.00550938	0.00715220	0.00729569
+TT[C>G]AA	0.00076648	0.01059557	0.00369962	0.00843351	0.00121393	0.00047050	0.00535012
+TT[C>G]AC	0.00006763	0.00089499	0.00027260	0.00150301	0.00014007	0.00037643	0.00064850
+TT[C>G]AG	0.00009017	0.00311804	0.00081781	0.00404977	0.00009338	0.00103518	0.00202656
+TT[C>G]AT	0.00013526	0.00230966	0.00085675	0.00313127	0.00009338	0.00018821	0.00113487
+TT[C>G]CA	0.00003382	0.00269942	0.00077886	0.00141949	0.00079373	0.00018821	0.00113487
+TT[C>G]CC	0.00002254	0.00050524	0.00027261	0.00075150	0.00014007	0.00000001	0.00089170
+TT[C>G]CG	0.00000000	0.00005774	0.00019472	0.00058451	0.00009338	0.00000002	0.00000001
+TT[C>G]CT	0.00012399	0.00095273	0.00109043	0.00079325	0.00084042	0.00141163	0.00040531
+TT[C>G]GA	0.00009018	0.00012992	0.00015578	0.00033400	0.00018676	0.00000002	0.00016213
+TT[C>G]GC	0.00000000	0.00010105	0.00000001	0.00000001	0.00000001	0.00000002	0.00000002
+TT[C>G]GG	0.00000000	0.00024540	0.00027261	0.00029225	0.00000001	0.00000002	0.00000001
+TT[C>G]GT	0.00000000	0.00025984	0.00015577	0.00045925	0.00000001	0.00000002	0.00000001
+TT[C>G]TA	0.00074394	0.00760743	0.00338809	0.00918505	0.00107386	0.00112926	0.00551226
+TT[C>G]TC	0.00022543	0.00412851	0.00132407	0.00325650	0.00079372	0.00056463	0.00308039
+TT[C>G]TG	0.00057486	0.00516786	0.00167456	0.00517702	0.00079372	0.00037642	0.00259400
+TT[C>G]TT	0.00091302	0.01120185	0.00369961	0.00851700	0.00163414	0.00141159	0.00494480
+TT[C>T]AA	0.00125118	0.00625048	0.00482902	0.00434199	0.00350173	0.00291733	0.00445845
+TT[C>T]AC	0.00136390	0.00526888	0.00241449	0.00400800	0.00242786	0.00197626	0.00243187
+TT[C>T]AG	0.00103701	0.00791055	0.00229764	0.00534399	0.00233448	0.00310553	0.00721461
+TT[C>T]AT	0.00179223	0.00884884	0.00521845	0.00642949	0.00261462	0.00282321	0.00551226
+TT[C>T]CA	0.00112719	0.00294478	0.00350495	0.00150299	0.00140069	0.00216447	0.00308040
+TT[C>T]CC	0.00157807	0.00317576	0.00295973	0.00137773	0.00242786	0.00122340	0.00089167
+TT[C>T]CG	0.00003382	0.00025983	0.00031155	0.00025050	0.00004669	0.00000001	0.00105383
+TT[C>T]CT	0.00121736	0.00362323	0.00295972	0.00283900	0.00275469	0.00282323	0.00405315
+TT[C>T]GA	0.00181478	0.00096711	0.00233663	0.00162826	0.00270800	0.00338789	0.00259402
+TT[C>T]GC	0.00145408	0.00082276	0.00198614	0.00058450	0.00149407	0.00141159	0.00445850
+TT[C>T]GG	0.00179223	0.00088050	0.00194720	0.00250502	0.00177420	0.00207036	0.00332360
+TT[C>T]GT	0.00173588	0.00108259	0.00124620	0.00208751	0.00135400	0.00225858	0.00356679
+TT[C>T]TA	0.00100320	0.00382535	0.00241451	0.00175349	0.00154076	0.00159982	0.00275614
+TT[C>T]TC	0.00081157	0.00382535	0.00249239	0.00246324	0.00256793	0.00178804	0.00308039
+TT[C>T]TG	0.00125118	0.00707330	0.00467325	0.00350698	0.00140069	0.00188213	0.00575547
+TT[C>T]TT	0.00123990	0.00668354	0.00377753	0.00496825	0.00368849	0.00338787	0.00591760
+TT[T>A]AA	0.00494837	0.00304573	0.00533529	0.00530228	0.01125222	0.00705811	0.00405314
+TT[T>A]AC	0.00005636	0.00043306	0.00035049	0.00008350	0.00051359	0.00000001	0.00048638
+TT[T>A]AG	0.00016908	0.00041862	0.00050627	0.00037575	0.00065366	0.00037643	0.00032425
+TT[T>A]AT	0.00023671	0.00095273	0.00093465	0.00162826	0.00228780	0.00075287	0.00016212
+TT[T>A]CA	0.00019162	0.00051967	0.00081782	0.00062625	0.00084042	0.00009412	0.00000001
+TT[T>A]CC	0.00015781	0.00025983	0.00031155	0.00037575	0.00046690	0.00056465	0.00024319
+TT[T>A]CG	0.00004509	0.00008661	0.00000001	0.00000001	0.00014007	0.00000002	0.00000002
+TT[T>A]CT	0.00019162	0.00072177	0.00140198	0.00020875	0.00121393	0.00009412	0.00008106
+TT[T>A]GA	0.00012399	0.00028870	0.00038944	0.00054275	0.00051359	0.00018821	0.00056744
+TT[T>A]GC	0.00005636	0.00015879	0.00007789	0.00012525	0.00023345	0.00000002	0.00000001
+TT[T>A]GG	0.00007890	0.00024540	0.00066205	0.00012525	0.00014007	0.00018822	0.00000001
+TT[T>A]GT	0.00009017	0.00037532	0.00046733	0.00087676	0.00037352	0.00000002	0.00000001
+TT[T>A]TA	0.00069886	0.00076506	0.00112937	0.00150301	0.00088710	0.00000001	0.00105382
+TT[T>A]TC	0.00002254	0.00046193	0.00089571	0.00050100	0.00037352	0.00009412	0.00000001
+TT[T>A]TG	0.00005636	0.00054854	0.00101254	0.00029225	0.00056028	0.00075287	0.00000001
+TT[T>A]TT	0.00109337	0.00160230	0.00229769	0.00150300	0.00289476	0.00131751	0.00105381
+TT[T>C]AA	0.00073267	0.00111151	0.00093464	0.00204576	0.00345504	0.00075287	0.00040530
+TT[T>C]AC	0.00068759	0.00075062	0.00015577	0.00083500	0.00126062	0.00065875	0.00178340
+TT[T>C]AG	0.00058614	0.00105377	0.00070098	0.00196226	0.00126062	0.00150573	0.00081062
+TT[T>C]AT	0.00144280	0.00213640	0.00268711	0.00242151	0.00653656	0.00103518	0.00097274
+TT[T>C]CA	0.00095811	0.00082279	0.00070098	0.00112725	0.00210104	0.00056464	0.00154020
+TT[T>C]CC	0.00329140	0.00116919	0.00105147	0.00091850	0.00270799	0.00169394	0.00105381
+TT[T>C]CG	0.00006763	0.00008661	0.00000001	0.00000001	0.00004669	0.00000002	0.00000002
+TT[T>C]CT	0.00087921	0.00134246	0.00183036	0.00200401	0.00219442	0.00216449	0.00129701
+TT[T>C]GA	0.00128500	0.00059182	0.00050627	0.00129426	0.00112055	0.00159984	0.00072957
+TT[T>C]GC	0.00024798	0.00037531	0.00190826	0.00075151	0.00032683	0.00028232	0.00048637
+TT[T>C]GG	0.00071013	0.00073619	0.00101254	0.00066800	0.00074703	0.00047054	0.00032425
+TT[T>C]GT	0.00041706	0.00066401	0.00237559	0.00104376	0.00102717	0.00122341	0.00048637
+TT[T>C]TA	0.00039452	0.00109708	0.00062309	0.00104375	0.00149407	0.00018821	0.00113488
+TT[T>C]TC	0.00072140	0.00108264	0.00144092	0.00217102	0.00130731	0.00075286	0.00056743
+TT[T>C]TG	0.00066504	0.00122699	0.00077887	0.00208751	0.00238117	0.00103519	0.00097275
+TT[T>C]TT	0.00206276	0.00190542	0.00311551	0.00258851	0.00359510	0.00282324	0.00218869
+TT[T>G]AA	0.00018035	0.00060628	0.00136303	0.00104376	0.00247456	0.00075287	0.00032425
+TT[T>G]AC	0.00003382	0.00017322	0.00015577	0.00033400	0.00056028	0.00018822	0.00000001
+TT[T>G]AG	0.00006763	0.00028871	0.00007789	0.00033400	0.00032683	0.00000002	0.00008107
+TT[T>G]AT	0.00000000	0.00036088	0.00097360	0.00050100	0.00121393	0.00056465	0.00072957
+TT[T>G]CA	0.00010145	0.00056298	0.00023366	0.00020875	0.00065366	0.00047054	0.00016212
+TT[T>G]CC	0.00000000	0.00027427	0.00019472	0.00020875	0.00046690	0.00018823	0.00000001
+TT[T>G]CG	0.00000000	0.00007218	0.00000001	0.00000001	0.00014007	0.00000002	0.00000002
+TT[T>G]CT	0.00016908	0.00034644	0.00054521	0.00041750	0.00112055	0.00000001	0.00113489
+TT[T>G]GA	0.00006763	0.00037532	0.00058416	0.00054275	0.00056028	0.00056465	0.00016213
+TT[T>G]GC	0.00003381	0.00046193	0.00120726	0.00037575	0.00056028	0.00018822	0.00000001
+TT[T>G]GG	0.00024798	0.00057741	0.00027260	0.00154476	0.00130731	0.00018821	0.00040532
+TT[T>G]GT	0.00028180	0.00050523	0.00085677	0.00087676	0.00084041	0.00028233	0.00056744
+TT[T>G]TA	0.00043960	0.00077950	0.00073992	0.00083500	0.00308152	0.00065876	0.00016213
+TT[T>G]TC	0.00037197	0.00041862	0.00062309	0.00112726	0.00504250	0.00047054	0.00024319
+TT[T>G]TG	0.00042833	0.00017321	0.00070099	0.00083501	0.00186759	0.00037643	0.00064851
+TT[T>G]TT	0.00068758	0.00166004	0.00218084	0.00162825	0.00597629	0.00178804	0.00251296
diff --git a/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_SBS288.txt b/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_SBS288.txt
new file mode 100644
index 0000000..663df24
--- /dev/null
+++ b/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_SBS288.txt
@@ -0,0 +1,289 @@
+MutationType	SBS288A	SBS288B	SBS288C	SBS288D	SBS288E	SBS288F	SBS288G	SBS288H	SBS288I	SBS288J	SBS288K
+T:A[C>A]A	0.00715491	0.00456728	0.00184590	0.01167448	0.00273583	0.00184278	0.00104337	0.01406790	0.00113006	0.00079094	0.00145977
+T:A[C>A]C	0.00326007	0.00098230	0.00272112	0.00879367	0.00100955	0.00229954	0.00048321	0.00343266	0.00071440	0.00108360	0.00180948
+T:A[C>A]G	0.00131720	0.00027637	0.00046945	0.00171821	0.00069580	0.00041344	0.00016216	0.00067959	0.00009377	0.00011450	0.00037542
+T:A[C>A]T	0.00288030	0.00076102	0.00407048	0.00900510	0.00049471	0.00138173	0.00063061	0.00509052	0.00034244	0.00087388	0.00186883
+T:A[C>G]A	0.00204936	0.00208571	0.00228600	0.00529966	0.00193193	0.00539507	0.00021304	0.00010205	0.00094090	0.00068189	0.00130731
+T:A[C>G]C	0.00138468	0.00336463	0.00147689	0.00216481	0.00091297	0.00304043	0.00029499	0.00039639	0.00039851	0.00030054	0.00082474
+T:A[C>G]G	0.00023603	0.00044191	0.00086691	0.00129978	0.00058633	0.00055678	0.00003720	0.00014807	0.00011104	0.00007481	0.00041395
+T:A[C>G]T	0.00147401	0.00600041	0.00231802	0.00392976	0.00156866	0.00487447	0.00005752	0.00061482	0.00054870	0.00080201	0.00060663
+T:A[C>T]A	0.00733580	0.00444604	0.00761133	0.00705798	0.00274323	0.00159914	0.00022150	0.00091309	0.00091001	0.00479275	0.00344320
+T:A[C>T]C	0.00496794	0.00113692	0.00684813	0.00255272	0.00179537	0.00131747	0.00025085	0.00043642	0.00048747	0.00244675	0.00203945
+T:A[C>T]G	0.00094630	0.00278534	0.00114630	0.00113829	0.00026467	0.00075185	0.00005860	0.00039920	0.00087562	0.01238829	0.04339129
+T:A[C>T]T	0.00509009	0.00229421	0.00823701	0.00716980	0.00174199	0.00136679	0.00022222	0.00007536	0.00033689	0.00374802	0.00307615
+T:A[T>A]A	0.00209744	0.00213366	0.00253235	0.00060182	0.00038682	0.00039844	0.01387850	0.00061768	0.01307719	0.00323957	0.00072810
+T:A[T>A]C	0.00122767	0.00115418	0.00201363	0.00209780	0.00014586	0.00082411	0.00199216	0.00065628	0.00131890	0.00267601	0.00019101
+T:A[T>A]G	0.00130961	0.00213222	0.00223206	0.00206212	0.00106272	0.00136958	0.01266772	0.00038427	0.00414240	0.00015485	0.00099463
+T:A[T>A]T	0.00083058	0.00177544	0.00595314	0.00272819	0.00076961	0.00177667	0.00354997	0.00170527	0.00245246	0.00362817	0.00263706
+T:A[T>C]A	0.00320925	0.00431325	0.00568543	0.00038955	0.01732753	0.00139662	0.00202170	0.00129348	0.01352739	0.00616344	0.00195048
+T:A[T>C]C	0.00013933	0.00035165	0.00399849	0.00138944	0.00672646	0.00062988	0.00004047	0.00092936	0.00003908	0.00163120	0.00079919
+T:A[T>C]G	0.00199963	0.00315866	0.00689746	0.00057361	0.01320344	0.00039145	0.00081116	0.00079486	0.00219047	0.00387516	0.00238454
+T:A[T>C]T	0.00421708	0.00558582	0.00523838	0.00063402	0.01060076	0.00414642	0.00018704	0.00104409	0.00087820	0.00269951	0.00242592
+T:A[T>G]A	0.00068209	0.00380048	0.00135603	0.00043786	0.00110550	0.00113546	0.00048203	0.00055636	0.00207568	0.00036630	0.00066361
+T:A[T>G]C	0.00054856	0.00496145	0.00118013	0.00012832	0.00051535	0.00068526	0.00012253	0.00052189	0.00036301	0.00045954	0.00007022
+T:A[T>G]G	0.00031412	0.00434573	0.00184893	0.00128692	0.00098307	0.00051515	0.00056178	0.00076341	0.00023333	0.00027211	0.00113670
+T:A[T>G]T	0.00071133	0.01086903	0.00421369	0.00053384	0.00109796	0.00161586	0.00020343	0.00140514	0.00063147	0.00058376	0.00054083
+T:C[C>A]A	0.00192230	0.00257925	0.00336608	0.01079404	0.00322941	0.00130197	0.00097074	0.00830439	0.00076864	0.00080865	0.00196214
+T:C[C>A]C	0.00251354	0.00108608	0.00359208	0.00875696	0.00242392	0.00162678	0.00099333	0.00318064	0.00086168	0.00274481	0.00107413
+T:C[C>A]G	0.00051729	0.00024475	0.00073514	0.00163762	0.00053705	0.00009058	0.00002393	0.00110376	0.00036472	0.00048010	0.00064127
+T:C[C>A]T	0.00000159	0.00200919	0.00543122	0.00831768	0.00118118	0.00114307	0.00064782	0.00524264	0.00063385	0.00582539	0.00285759
+T:C[C>G]A	0.00117601	0.00175183	0.00136877	0.00169901	0.00167634	0.00217325	0.00009137	0.00074225	0.00064078	0.00000103	0.00143857
+T:C[C>G]C	0.00054308	0.00379342	0.00216980	0.00162556	0.00168764	0.00239103	0.00015824	0.00006656	0.00058449	0.00002605	0.00192278
+T:C[C>G]G	0.00029746	0.00008002	0.00069099	0.00036560	0.00046172	0.00084816	0.00006723	0.00057278	0.00008163	0.00004500	0.00007884
+T:C[C>G]T	0.00048585	0.00643539	0.00253925	0.00140429	0.00185433	0.00317752	0.00024357	0.00096103	0.00044426	0.00018560	0.00122972
+T:C[C>T]A	0.00655822	0.00296652	0.00604535	0.00189411	0.00338859	0.00331510	0.00046666	0.00096427	0.00059224	0.00168420	0.00280943
+T:C[C>T]C	0.00837801	0.00205928	0.00587964	0.00153720	0.00206319	0.00229164	0.00048811	0.00071086	0.00080525	0.00263406	0.00267897
+T:C[C>T]G	0.00202792	0.00004726	0.00233570	0.00036540	0.00026263	0.00136631	0.00016822	0.00073613	0.00050141	0.00732254	0.02048709
+T:C[C>T]T	0.00674502	0.00221997	0.00920028	0.00553798	0.00260955	0.00111128	0.00059787	0.00109281	0.00057882	0.00351942	0.00352210
+T:C[T>A]A	0.00000000	0.00117765	0.00078619	0.00041235	0.00049788	0.00010650	0.02716562	0.00000903	0.01722704	0.00009253	0.00025693
+T:C[T>A]C	0.00061139	0.00181388	0.00375260	0.00192321	0.00128044	0.00059442	0.01252014	0.00168699	0.00139600	0.00050156	0.00034658
+T:C[T>A]G	0.00114293	0.00136982	0.00177194	0.00003907	0.00114989	0.00093409	0.03714001	0.00094444	0.00325034	0.00029619	0.00022701
+T:C[T>A]T	0.00070511	0.00167714	0.00276821	0.00242300	0.00075905	0.00185476	0.01207761	0.00123238	0.00262904	0.00069442	0.00010995
+T:C[T>C]A	0.00104337	0.00261750	0.00610532	0.00011000	0.00412783	0.00092633	0.00089301	0.00093830	0.00139403	0.00461216	0.00098090
+T:C[T>C]C	0.00016840	0.00001388	0.00513272	0.00068206	0.00421534	0.00181829	0.00016406	0.00117230	0.00004156	0.00191385	0.00041692
+T:C[T>C]G	0.00151469	0.00076519	0.00706462	0.00045140	0.00481708	0.00088461	0.00036138	0.00020913	0.00054297	0.00437431	0.00098851
+T:C[T>C]T	0.00022892	0.00141125	0.00687817	0.00050293	0.00517393	0.00110610	0.00022836	0.00084201	0.00038025	0.00291964	0.00148319
+T:C[T>G]A	0.00013839	0.00121554	0.00097659	0.00010814	0.00102833	0.00094737	0.00064376	0.00043519	0.00137343	0.00013320	0.00017954
+T:C[T>G]C	0.00038154	0.00278569	0.00111086	0.00009484	0.00111009	0.00113726	0.00036239	0.00016405	0.00024474	0.00036229	0.00058644
+T:C[T>G]G	0.00055906	0.00224428	0.00139937	0.00071646	0.00103483	0.00147635	0.00123674	0.00024301	0.00059231	0.00044703	0.00040560
+T:C[T>G]T	0.00042785	0.00420561	0.00280983	0.00010235	0.00188745	0.00258259	0.00022789	0.00082350	0.00027355	0.00037513	0.00100888
+T:G[C>A]A	0.00114107	0.00173863	0.00082933	0.00247959	0.00208249	0.00121198	0.00032297	0.01558573	0.00046439	0.00027805	0.00106247
+T:G[C>A]C	0.00275996	0.00139141	0.00201191	0.00451038	0.00127482	0.00097207	0.00048139	0.00363733	0.00058961	0.00061474	0.00020744
+T:G[C>A]G	0.00134550	0.00030731	0.00038629	0.00063503	0.00019090	0.00023156	0.00008112	0.00151398	0.00013980	0.00007870	0.00036465
+T:G[C>A]T	0.00055607	0.00138270	0.00237385	0.00369205	0.00032905	0.00151928	0.00025192	0.00731241	0.00024374	0.00089408	0.00130231
+T:G[C>G]A	0.00104864	0.00022425	0.00132079	0.00157672	0.00065559	0.00240919	0.00018454	0.00031171	0.00018154	0.00025478	0.00060890
+T:G[C>G]C	0.00098015	0.00116636	0.00160435	0.00207462	0.00101630	0.00152901	0.00014352	0.00005410	0.00021123	0.00028901	0.00055676
+T:G[C>G]G	0.00015873	0.00033638	0.00031019	0.00070540	0.00032991	0.00031963	0.00007753	0.00001704	0.00001670	0.00008956	0.00002803
+T:G[C>G]T	0.00083609	0.00203130	0.00126585	0.00135167	0.00099850	0.00216754	0.00006289	0.00080556	0.00045860	0.00023789	0.00021786
+T:G[C>T]A	0.00705867	0.00184292	0.00458782	0.00165556	0.00185776	0.00269334	0.00016105	0.00048693	0.00062268	0.00572930	0.00208005
+T:G[C>T]C	0.00728852	0.00087295	0.00589748	0.00180067	0.00121611	0.00017114	0.00032595	0.00080789	0.00019653	0.00774775	0.00259038
+T:G[C>T]G	0.00183554	0.00015996	0.00164224	0.00019041	0.00005605	0.00029792	0.00005074	0.00089137	0.00066683	0.01004505	0.02465906
+T:G[C>T]T	0.00541905	0.00132646	0.00670689	0.00385351	0.00035133	0.00003308	0.00014498	0.00046573	0.00097005	0.00703341	0.00168211
+T:G[T>A]A	0.00013850	0.00134180	0.00122289	0.00094793	0.00008730	0.00036344	0.01001593	0.00019078	0.00618345	0.00051234	0.00024038
+T:G[T>A]C	0.00006689	0.00120924	0.00089476	0.00110239	0.00060228	0.00066572	0.00194839	0.00078162	0.00079967	0.00079419	0.00027430
+T:G[T>A]G	0.00064915	0.00162038	0.00132985	0.00102040	0.00019098	0.00083510	0.00595728	0.00059359	0.00000000	0.00051541	0.00021797
+T:G[T>A]T	0.00020376	0.00150312	0.00136242	0.00173795	0.00054659	0.00104170	0.00183057	0.00093279	0.00023199	0.00044040	0.00038612
+T:G[T>C]A	0.00068775	0.00255829	0.00129105	0.00062417	0.00533854	0.00119657	0.00016014	0.00028935	0.00110665	0.00808353	0.00013951
+T:G[T>C]C	0.00008880	0.00040373	0.00121002	0.00059443	0.00386176	0.00061606	0.00006194	0.00045139	0.00008034	0.00220385	0.00066294
+T:G[T>C]G	0.00043152	0.00077033	0.00222545	0.00014545	0.00447231	0.00061589	0.00018582	0.00119528	0.00022765	0.00431963	0.00089119
+T:G[T>C]T	0.00148036	0.00134830	0.00123554	0.00044795	0.00469296	0.00173301	0.00001235	0.00095537	0.00046207	0.00419656	0.00072248
+T:G[T>G]A	0.00009232	0.00093044	0.00045719	0.00006281	0.00026192	0.00091664	0.00028214	0.00001370	0.00043499	0.00007519	0.00046809
+T:G[T>G]C	0.00015553	0.00082893	0.00019813	0.00014126	0.00039183	0.00043071	0.00002629	0.00003394	0.00006067	0.00008943	0.00023362
+T:G[T>G]G	0.00015675	0.00078184	0.00046694	0.00093150	0.00064634	0.00072816	0.00017519	0.00007585	0.00016027	0.00007672	0.00031680
+T:G[T>G]T	0.00004590	0.00188778	0.00045289	0.00024429	0.00069478	0.00138158	0.00002312	0.00013482	0.00019537	0.00033078	0.00046660
+T:T[C>A]A	0.00392357	0.00516314	0.00445850	0.00661949	0.00030236	0.00458296	0.00099794	0.01207977	0.00060540	0.00082851	0.00058900
+T:T[C>A]C	0.00701733	0.00232785	0.00280163	0.00680975	0.00156222	0.00402389	0.00117883	0.00770743	0.00039902	0.00142554	0.00054881
+T:T[C>A]G	0.00124629	0.00058703	0.00051576	0.00046520	0.00034060	0.00039249	0.00004976	0.00152193	0.00017115	0.00033709	0.00029597
+T:T[C>A]T	0.00263649	0.00344143	0.00386332	0.00612916	0.00005693	0.00613070	0.00094823	0.01432901	0.00055078	0.00231788	0.00160687
+T:T[C>G]A	0.00140014	0.00084950	0.00174152	0.00161725	0.00051649	0.01063187	0.00019529	0.00255253	0.00083809	0.00054519	0.00070122
+T:T[C>G]C	0.00098577	0.00451836	0.00238598	0.00192181	0.00141720	0.00631947	0.00028600	0.00085954	0.00096084	0.00016892	0.00148349
+T:T[C>G]G	0.00024942	0.00044602	0.00046228	0.00026658	0.00013027	0.00057021	0.00005423	0.00038594	0.00006688	0.00003220	0.00031042
+T:T[C>G]T	0.00152402	0.00563381	0.00201279	0.00206816	0.00213703	0.01583032	0.00016290	0.00379960	0.00099514	0.00056079	0.00119111
+T:T[C>T]A	0.00829856	0.00513675	0.00558213	0.00140349	0.00155750	0.00997814	0.00022392	0.00380023	0.00121091	0.00234348	0.00145521
+T:T[C>T]C	0.00971136	0.00205826	0.00547934	0.00173745	0.00199201	0.00544101	0.00028198	0.00215553	0.00114281	0.00225955	0.00181089
+T:T[C>T]G	0.00110066	0.00018189	0.00179233	0.00022365	0.00026418	0.00186762	0.00006651	0.00057136	0.00022197	0.00478318	0.01302123
+T:T[C>T]T	0.00601245	0.00104398	0.00819154	0.00465034	0.00129687	0.00576582	0.00042462	0.00175922	0.00017948	0.00290089	0.00234438
+T:T[T>A]A	0.00051031	0.00360306	0.00222040	0.00110260	0.00005323	0.00237795	0.01533920	0.00152021	0.01957662	0.00154257	0.00012666
+T:T[T>A]C	0.00027863	0.00372910	0.00330654	0.00228419	0.00056620	0.00237181	0.00513906	0.00158838	0.00088058	0.00080163	0.00006007
+T:T[T>A]G	0.00016073	0.00218639	0.00149116	0.00056421	0.00063381	0.00013194	0.01305344	0.00086035	0.00597429	0.00028143	0.00007319
+T:T[T>A]T	0.00044258	0.00909558	0.00554483	0.00510320	0.00000356	0.00183919	0.00620332	0.00275822	0.00498837	0.00142732	0.00053216
+T:T[T>C]A	0.00041321	0.00333252	0.00349030	0.00036024	0.00812050	0.00057538	0.00072782	0.00128965	0.00446281	0.00785336	0.00049458
+T:T[T>C]C	0.00003046	0.00053517	0.00184570	0.00107975	0.00378548	0.00293585	0.00018509	0.00072101	0.00001120	0.00328193	0.00036723
+T:T[T>C]G	0.00042440	0.00057723	0.00252411	0.00050712	0.00384869	0.00068188	0.00018096	0.00055634	0.00076846	0.00323931	0.00012920
+T:T[T>C]T	0.00096582	0.00110920	0.00315560	0.00040696	0.00676077	0.00176525	0.00023213	0.00160894	0.00013521	0.00649003	0.00043095
+T:T[T>G]A	0.00085862	0.00405038	0.00147933	0.00033031	0.00049260	0.00267431	0.00048702	0.00008167	0.00255726	0.00016477	0.00040951
+T:T[T>G]C	0.00016436	0.00746022	0.00111214	0.00047693	0.00071325	0.00171076	0.00034978	0.00086667	0.00021931	0.00024932	0.00108428
+T:T[T>G]G	0.00048484	0.00349435	0.00071611	0.00112224	0.00121511	0.00123765	0.00054090	0.00075100	0.00099983	0.00016891	0.00046167
+T:T[T>G]T	0.00093319	0.01248478	0.00311790	0.00068956	0.00215638	0.00371112	0.00043965	0.00123735	0.00045332	0.00113338	0.00092525
+U:A[C>A]A	0.00478011	0.00324303	0.00238977	0.00516772	0.00280738	0.00102577	0.00065532	0.01041700	0.00028349	0.00081594	0.00032554
+U:A[C>A]C	0.00257791	0.00132302	0.00238555	0.00410248	0.00098464	0.00145834	0.00039478	0.00225775	0.00022326	0.00046931	0.00162532
+U:A[C>A]G	0.00087215	0.00020670	0.00053314	0.00069996	0.00035456	0.00026656	0.00012472	0.00086700	0.00009023	0.00009332	0.00006585
+U:A[C>A]T	0.00197282	0.00159471	0.00401037	0.00456774	0.00046647	0.00122331	0.00025921	0.00527770	0.00066705	0.00090322	0.00059574
+U:A[C>G]A	0.00133425	0.00254842	0.00132249	0.00235205	0.00190651	0.00340999	0.00005914	0.00057816	0.00049578	0.00020618	0.00083860
+U:A[C>G]C	0.00122672	0.00294730	0.00131060	0.00092061	0.00083665	0.00212858	0.00011275	0.00017258	0.00046152	0.00027488	0.00042526
+U:A[C>G]G	0.00031998	0.00035039	0.00045056	0.00034134	0.00040811	0.00064776	0.00004595	0.00036080	0.00011070	0.00003387	0.00013506
+U:A[C>G]T	0.00144319	0.00627459	0.00141514	0.00157285	0.00178439	0.00385126	0.00014866	0.00126604	0.00051847	0.00061128	0.00089167
+U:A[C>T]A	0.00502390	0.00422392	0.00392428	0.00266646	0.00198056	0.00298699	0.00010501	0.00035620	0.00072082	0.00446476	0.00310002
+U:A[C>T]C	0.00373989	0.00155382	0.00359982	0.00142117	0.00124800	0.00146076	0.00028152	0.00091783	0.00037418	0.00196371	0.00134479
+U:A[C>T]G	0.00079255	0.00187650	0.00023793	0.00034070	0.00080798	0.00049900	0.00011250	0.00027295	0.00060095	0.00963014	0.03895035
+U:A[C>T]T	0.00441007	0.00318380	0.00392032	0.00324359	0.00116974	0.00154755	0.00012903	0.00076607	0.00061889	0.00352814	0.00154877
+U:A[T>A]A	0.00093344	0.00293814	0.00373942	0.00104232	0.00045254	0.00080633	0.00596813	0.00048866	0.00652430	0.00333682	0.00069919
+U:A[T>A]C	0.00050573	0.00153051	0.00252514	0.00105164	0.00013629	0.00082168	0.00123356	0.00053214	0.00034840	0.00174876	0.00075380
+U:A[T>A]G	0.00090330	0.00275384	0.00345360	0.00128351	0.00132464	0.00088535	0.00619328	0.00132482	0.00286934	0.00014623	0.00103064
+U:A[T>A]T	0.00039122	0.00197977	0.00972707	0.00188964	0.00077495	0.00219046	0.00165103	0.00230683	0.00246113	0.00349970	0.00241019
+U:A[T>C]A	0.00273130	0.00282305	0.00774931	0.00001256	0.00818065	0.00224922	0.00119719	0.00013012	0.00573215	0.00581181	0.00108042
+U:A[T>C]C	0.00010615	0.00061362	0.00482948	0.00062620	0.00382406	0.00035100	0.00002907	0.00067846	0.00008373	0.00128859	0.00092842
+U:A[T>C]G	0.00110420	0.00220713	0.00865848	0.00000648	0.00891062	0.00029499	0.00059956	0.00069354	0.00108186	0.00352858	0.00185656
+U:A[T>C]T	0.00305513	0.00417783	0.00807459	0.00046226	0.00561157	0.00277311	0.00043946	0.00097369	0.00036281	0.00296885	0.00168256
+U:A[T>G]A	0.00050471	0.00300489	0.00081343	0.00012585	0.00107051	0.00171254	0.00031503	0.00089853	0.00111220	0.00027475	0.00015125
+U:A[T>G]C	0.00022403	0.00380449	0.00127580	0.00010049	0.00078143	0.00055577	0.00007530	0.00092010	0.00013278	0.00018356	0.00044845
+U:A[T>G]G	0.00040405	0.00334589	0.00195463	0.00065372	0.00111012	0.00086531	0.00038665	0.00053943	0.00038420	0.00032966	0.00083550
+U:A[T>G]T	0.00069410	0.01137570	0.00365782	0.00044037	0.00152607	0.00265602	0.00043367	0.00109845	0.00025074	0.00066144	0.00127725
+U:C[C>A]A	0.00168195	0.00257583	0.00381417	0.00477279	0.00453279	0.00154881	0.00061023	0.00677283	0.00048372	0.00138583	0.00183221
+U:C[C>A]C	0.00183441	0.00178621	0.00404331	0.00490742	0.00289623	0.00063885	0.00064962	0.00215545	0.00050318	0.00307070	0.00178609
+U:C[C>A]G	0.00051713	0.00020231	0.00107305	0.00064679	0.00058006	0.00031183	0.00006960	0.00102713	0.00022543	0.00049417	0.00024049
+U:C[C>A]T	0.00057411	0.00282300	0.00803567	0.00526517	0.00167496	0.00167574	0.00041437	0.00454824	0.00051511	0.00604830	0.00159926
+U:C[C>G]A	0.00116509	0.00226709	0.00138597	0.00035003	0.00203689	0.00249709	0.00015606	0.00077181	0.00027128	0.00032215	0.00011985
+U:C[C>G]C	0.00134058	0.00347171	0.00104554	0.00048328	0.00267465	0.00229343	0.00011830	0.00039894	0.00035623	0.00002018	0.00067583
+U:C[C>G]G	0.00036600	0.00017898	0.00075258	0.00009350	0.00062674	0.00088777	0.00000710	0.00029485	0.00007516	0.00000393	0.00063868
+U:C[C>G]T	0.00152440	0.00707165	0.00197415	0.00045417	0.00318885	0.00469970	0.00028120	0.00085983	0.00051011	0.00002214	0.00193540
+U:C[C>T]A	0.00608939	0.00435718	0.00332798	0.00117523	0.00330090	0.00298646	0.00052962	0.00165578	0.00064585	0.00123120	0.00185386
+U:C[C>T]C	0.00691624	0.00316069	0.00402854	0.00061447	0.00201267	0.00218146	0.00064686	0.00093220	0.00094135	0.00221900	0.00189818
+U:C[C>T]G	0.00095280	0.00147335	0.00056367	0.00027293	0.00039297	0.00148509	0.00061492	0.00093845	0.00002754	0.00619346	0.02237094
+U:C[C>T]T	0.00645503	0.00230247	0.00789165	0.00353861	0.00219835	0.00302354	0.00045178	0.00009838	0.00095562	0.00367447	0.00314349
+U:C[T>A]A	0.00012048	0.00150560	0.00427951	0.00024044	0.00133041	0.00016983	0.01180547	0.00056703	0.00921309	0.00021387	0.00080248
+U:C[T>A]C	0.00075001	0.00240895	0.00605523	0.00114362	0.00226133	0.00064539	0.00601564	0.00081670	0.00117782	0.00035209	0.00184173
+U:C[T>A]G	0.00213312	0.00112781	0.00726710	0.00085960	0.00353639	0.00005204	0.01873451	0.00046535	0.00307654	0.00062254	0.00106129
+U:C[T>A]T	0.00156609	0.00332319	0.00680100	0.00203888	0.00138478	0.00132830	0.00652396	0.00093921	0.00196515	0.00039706	0.00109439
+U:C[T>C]A	0.00098371	0.00208340	0.00777844	0.00050557	0.00313488	0.00120735	0.00078313	0.00025060	0.00073037	0.00330515	0.00156800
+U:C[T>C]C	0.00091090	0.00025297	0.00720075	0.00053718	0.00297138	0.00105222	0.00006722	0.00046404	0.00040781	0.00169342	0.00139950
+U:C[T>C]G	0.00088669	0.00059759	0.01083224	0.00053229	0.00433478	0.00014321	0.00038431	0.00060290	0.00021268	0.00379489	0.00217574
+U:C[T>C]T	0.00081668	0.00153348	0.01131588	0.00059411	0.00348619	0.00117041	0.00011067	0.00125645	0.00053231	0.00336239	0.00197024
+U:C[T>G]A	0.00011863	0.00122900	0.00067550	0.00000538	0.00061949	0.00115043	0.00005951	0.00038818	0.00098928	0.00012170	0.00038482
+U:C[T>G]C	0.00019802	0.00336509	0.00088053	0.00002558	0.00131009	0.00096047	0.00013147	0.00047950	0.00037827	0.00030706	0.00073804
+U:C[T>G]G	0.00012316	0.00201839	0.00161890	0.00048584	0.00119550	0.00168424	0.00043412	0.00060681	0.00065373	0.00045260	0.00090502
+U:C[T>G]T	0.00059894	0.00639806	0.00287386	0.00001273	0.00310562	0.00271632	0.00024461	0.00065275	0.00015656	0.00086632	0.00179558
+U:G[C>A]A	0.00074811	0.00131538	0.00213948	0.00068014	0.00222169	0.00149919	0.00008506	0.01253309	0.00044970	0.00016128	0.00162564
+U:G[C>A]C	0.00246082	0.00096249	0.00217523	0.00176765	0.00101865	0.00084399	0.00044513	0.00346794	0.00009009	0.00077610	0.00042076
+U:G[C>A]G	0.00089012	0.00049570	0.00013864	0.00036113	0.00020437	0.00009849	0.00008247	0.00098660	0.00003643	0.00012846	0.00037695
+U:G[C>A]T	0.00017034	0.00178287	0.00312527	0.00139218	0.00099267	0.00174468	0.00021268	0.00781007	0.00024938	0.00085611	0.00100678
+U:G[C>G]A	0.00047126	0.00109743	0.00024701	0.00072298	0.00141091	0.00148006	0.00006477	0.00057938	0.00024100	0.00010282	0.00031475
+U:G[C>G]C	0.00095412	0.00108393	0.00087231	0.00076199	0.00123305	0.00156332	0.00005439	0.00009672	0.00033378	0.00015635	0.00016222
+U:G[C>G]G	0.00021054	0.00029927	0.00044016	0.00018368	0.00012856	0.00037765	0.00000801	0.00002834	0.00006645	0.00002063	0.00004870
+U:G[C>G]T	0.00069396	0.00263144	0.00059641	0.00056878	0.00183530	0.00226244	0.00004658	0.00054340	0.00043568	0.00004052	0.00083924
+U:G[C>T]A	0.00682358	0.00380164	0.00341067	0.00058391	0.00093710	0.00300622	0.00028036	0.00128007	0.00061382	0.00587392	0.00155686
+U:G[C>T]C	0.00613270	0.00193646	0.00292255	0.00056296	0.00101126	0.00161573	0.00045294	0.00121457	0.00006004	0.00787968	0.00141860
+U:G[C>T]G	0.00035017	0.00075799	0.00021286	0.00000253	0.00000982	0.00156238	0.00013934	0.00145042	0.00054248	0.01144913	0.02486613
+U:G[C>T]T	0.00519276	0.00208141	0.00451759	0.00196915	0.00062759	0.00036099	0.00010621	0.00049290	0.00063078	0.00640137	0.00263360
+U:G[T>A]A	0.00010274	0.00204297	0.00171193	0.00066882	0.00023423	0.00019239	0.00507259	0.00080022	0.00369253	0.00056007	0.00050797
+U:G[T>A]C	0.00049823	0.00156946	0.00193176	0.00032726	0.00074138	0.00035485	0.00105151	0.00058881	0.00047903	0.00063223	0.00043623
+U:G[T>A]G	0.00117862	0.00169936	0.00257035	0.00021955	0.00066990	0.00057031	0.00389226	0.00077236	0.00001031	0.00060575	0.00041353
+U:G[T>A]T	0.00052251	0.00163276	0.00333535	0.00125108	0.00018897	0.00128938	0.00108932	0.00097292	0.00040096	0.00085646	0.00058247
+U:G[T>C]A	0.00053000	0.00213093	0.00259520	0.00019837	0.00349324	0.00117995	0.00028364	0.00069620	0.00050787	0.00956448	0.00074542
+U:G[T>C]C	0.00013877	0.00080172	0.00217607	0.00013453	0.00264952	0.00079816	0.00011208	0.00082428	0.00008323	0.00229715	0.00067707
+U:G[T>C]G	0.00074086	0.00086481	0.00255345	0.00034158	0.00362727	0.00118287	0.00016151	0.00012949	0.00015423	0.00522371	0.00029927
+U:G[T>C]T	0.00112351	0.00187712	0.00209758	0.00022058	0.00317189	0.00238648	0.00004206	0.00055746	0.00020842	0.00580937	0.00122277
+U:G[T>G]A	0.00001506	0.00101820	0.00014529	0.00005612	0.00054537	0.00083753	0.00016351	0.00009760	0.00030182	0.00003782	0.00062332
+U:G[T>G]C	0.00011863	0.00105466	0.00003276	0.00006959	0.00055256	0.00057107	0.00003551	0.00031517	0.00002731	0.00014550	0.00033656
+U:G[T>G]G	0.00016847	0.00112738	0.00045101	0.00017994	0.00103841	0.00086961	0.00003317	0.00069287	0.00018271	0.00007240	0.00031367
+U:G[T>G]T	0.00027621	0.00278112	0.00036152	0.00015690	0.00089149	0.00140447	0.00007711	0.00037092	0.00015243	0.00052439	0.00034574
+U:T[C>A]A	0.00174904	0.00762750	0.00800191	0.00285237	0.00112188	0.00399948	0.00048940	0.00968127	0.00058427	0.00088994	0.00191307
+U:T[C>A]C	0.00453990	0.00396006	0.00376421	0.00366387	0.00141054	0.00283127	0.00037081	0.00582528	0.00085044	0.00139002	0.00122566
+U:T[C>A]G	0.00096162	0.00025706	0.00077963	0.00001475	0.00042347	0.00053129	0.00004497	0.00138701	0.00013496	0.00031496	0.00007820
+U:T[C>A]T	0.00208668	0.00440519	0.00734805	0.00238891	0.00081406	0.00602402	0.00052045	0.01588928	0.00099406	0.00193040	0.00170027
+U:T[C>G]A	0.00123674	0.00293702	0.00121932	0.00075200	0.00212073	0.00837752	0.00021306	0.00208885	0.00043749	0.00016209	0.00121419
+U:T[C>G]C	0.00156758	0.00550761	0.00181307	0.00073746	0.00198025	0.00517570	0.00007837	0.00105692	0.00099659	0.00042537	0.00113294
+U:T[C>G]G	0.00014967	0.00059379	0.00048437	0.00033915	0.00076786	0.00058291	0.00001878	0.00015369	0.00003388	0.00005859	0.00006384
+U:T[C>G]T	0.00227502	0.00793939	0.00342919	0.00073965	0.00314339	0.01598948	0.00046021	0.00461567	0.00067917	0.00057843	0.00271801
+U:T[C>T]A	0.00925271	0.01224208	0.00647495	0.00111585	0.00142409	0.01049391	0.00041386	0.00407574	0.00189542	0.00264832	0.00167082
+U:T[C>T]C	0.01074328	0.00484245	0.00429543	0.00070389	0.00178419	0.00673070	0.00074499	0.00141279	0.00076186	0.00249743	0.00178749
+U:T[C>T]G	0.00071494	0.00101041	0.00089555	0.00015571	0.00075968	0.00144788	0.00020403	0.00102113	0.00005560	0.00386133	0.01623762
+U:T[C>T]T	0.00829502	0.00378239	0.00494489	0.00241833	0.00053224	0.00732521	0.00040163	0.00179624	0.00092365	0.00238939	0.00190691
+U:T[T>A]A	0.00133508	0.00363591	0.00498859	0.00081519	0.00056594	0.00253060	0.00736110	0.00143249	0.01130687	0.00196610	0.00096679
+U:T[T>A]C	0.00114880	0.00463805	0.00470022	0.00136793	0.00063945	0.00092833	0.00264054	0.00131708	0.00106569	0.00080348	0.00054701
+U:T[T>A]G	0.00085611	0.00324116	0.00389666	0.00078605	0.00099674	0.00057751	0.00779092	0.00057764	0.00420127	0.00032567	0.00093621
+U:T[T>A]T	0.00076466	0.01307355	0.00930619	0.00420234	0.00018963	0.00133627	0.00374902	0.00337102	0.00442347	0.00218616	0.00139823
+U:T[T>C]A	0.00031396	0.00429662	0.00633224	0.00031398	0.00410170	0.00043630	0.00046036	0.00174933	0.00273446	0.00920510	0.00061237
+U:T[T>C]C	0.00015245	0.00095011	0.00376699	0.00076124	0.00274722	0.00193190	0.00006626	0.00090722	0.00019793	0.00305019	0.00106046
+U:T[T>C]G	0.00041761	0.00121671	0.00410806	0.00030977	0.00327457	0.00094778	0.00005972	0.00067143	0.00062715	0.00438752	0.00007767
+U:T[T>C]T	0.00134697	0.00301548	0.00534098	0.00043236	0.00329681	0.00206596	0.00012690	0.00052514	0.00081383	0.00874449	0.00065029
+U:T[T>G]A	0.00031738	0.00495025	0.00144189	0.00012528	0.00093805	0.00196949	0.00042066	0.00091015	0.00119161	0.00041117	0.00027606
+U:T[T>G]C	0.00046934	0.00735979	0.00164034	0.00018677	0.00138111	0.00104499	0.00016718	0.00078447	0.00035122	0.00011832	0.00095451
+U:T[T>G]G	0.00061115	0.00478413	0.00146446	0.00061555	0.00111798	0.00141154	0.00045140	0.00077031	0.00073160	0.00032351	0.00088246
+U:T[T>G]T	0.00168588	0.01565537	0.00414560	0.00038306	0.00484436	0.00481783	0.00043850	0.00142964	0.00079360	0.00143498	0.00113873
+N:A[C>A]A	0.02989746	0.01128269	0.00014736	0.04033599	0.01636844	0.00035408	0.00390608	0.05073179	0.00426074	0.00296863	0.00460509
+N:A[C>A]C	0.01385447	0.00151234	0.00252827	0.02770482	0.00468855	0.00466202	0.00219794	0.01397029	0.00248864	0.00309122	0.00198822
+N:A[C>A]G	0.00356413	0.00079617	0.00040160	0.00520511	0.00147428	0.00060932	0.00033538	0.00258831	0.00064683	0.00029693	0.00045328
+N:A[C>A]T	0.01164347	0.00024309	0.00387868	0.03414084	0.00440276	0.00285244	0.00207591	0.02050769	0.00192458	0.00395476	0.00301694
+N:A[C>G]A	0.00985434	0.00360891	0.00252771	0.01563211	0.01058111	0.01251010	0.00077605	0.00094009	0.00269629	0.00169433	0.00319890
+N:A[C>G]C	0.00461383	0.00594920	0.00148183	0.00631550	0.00424832	0.00902008	0.00016470	0.00163420	0.00178532	0.00100971	0.00092325
+N:A[C>G]G	0.00132160	0.00083592	0.00151608	0.00289698	0.00108296	0.00140106	0.00006944	0.00066328	0.00060434	0.00001099	0.00058890
+N:A[C>G]T	0.00429546	0.01373438	0.00398450	0.01222264	0.00637231	0.01244656	0.00024781	0.00348351	0.00232661	0.00165181	0.00208028
+N:A[C>T]A	0.02120342	0.00647633	0.01430488	0.01894756	0.00923346	0.00723099	0.00060795	0.00293713	0.00216010	0.01465360	0.01286655
+N:A[C>T]C	0.01624980	0.00095792	0.01108013	0.00701847	0.00520979	0.00431457	0.00041959	0.00148761	0.00156396	0.00709439	0.00488349
+N:A[C>T]G	0.01024154	0.00715708	0.00165963	0.00151140	0.00321766	0.00080509	0.00146567	0.00114945	0.00089192	0.02574723	0.14033014
+N:A[C>T]T	0.01498948	0.00525985	0.01432829	0.02161503	0.00638150	0.00391943	0.00056817	0.00283878	0.00151348	0.00862902	0.00865739
+N:A[T>A]A	0.00543768	0.00303622	0.00404586	0.00490750	0.00190506	0.00180279	0.04038497	0.00114142	0.07243501	0.01294048	0.00320130
+N:A[T>A]C	0.00179668	0.00305174	0.00230259	0.00668827	0.00185949	0.00294448	0.00722752	0.00229013	0.00535041	0.00839040	0.00226851
+N:A[T>A]G	0.00696480	0.00396410	0.00323350	0.00594968	0.00424019	0.00227542	0.04551534	0.00159718	0.02508249	0.00124113	0.00233985
+N:A[T>A]T	0.00464138	0.00318364	0.01217301	0.01055916	0.00034543	0.00989600	0.01073798	0.00697957	0.01510774	0.01247530	0.00566354
+N:A[T>C]A	0.00908648	0.00778142	0.00559495	0.00074725	0.03697259	0.00525883	0.00799474	0.00308775	0.04794485	0.02266784	0.00594863
+N:A[T>C]C	0.00038438	0.00138227	0.00289464	0.00330527	0.01383118	0.00356398	0.00025874	0.00355795	0.00043786	0.00619951	0.00145354
+N:A[T>C]G	0.00698532	0.00720857	0.00730403	0.00292352	0.03131592	0.00344565	0.00268360	0.00158300	0.00955418	0.01242582	0.00357643
+N:A[T>C]T	0.01028534	0.00927439	0.00674351	0.00276706	0.02362579	0.01108016	0.00047201	0.00568036	0.00429263	0.01261619	0.00703211
+N:A[T>G]A	0.00305125	0.00798514	0.00223515	0.00136570	0.00381236	0.00501527	0.00123766	0.00214840	0.00929505	0.00066447	0.00159294
+N:A[T>G]C	0.00124007	0.01031221	0.00219985	0.00111539	0.00182417	0.00231891	0.00061079	0.00141716	0.00015210	0.00105583	0.00061773
+N:A[T>G]G	0.00307510	0.00873910	0.00388845	0.00393549	0.00276802	0.00245807	0.00121529	0.00172264	0.00330938	0.00069046	0.00236966
+N:A[T>G]T	0.00286423	0.02814725	0.00645009	0.00299620	0.00313541	0.00378216	0.00029406	0.00339143	0.00227329	0.00203498	0.00349629
+N:C[C>A]A	0.01303363	0.00337320	0.00049708	0.03583163	0.01939515	0.00270914	0.00399068	0.03324488	0.00324521	0.00289412	0.00761491
+N:C[C>A]C	0.01029065	0.00104336	0.00336029	0.03395805	0.00997556	0.00201968	0.00307885	0.01220036	0.00281212	0.00765379	0.00345227
+N:C[C>A]G	0.00164529	0.00032376	0.00059051	0.00389620	0.00245867	0.00011946	0.00043357	0.00339813	0.00032199	0.00129960	0.00019518
+N:C[C>A]T	0.00438713	0.00144173	0.00423299	0.03292999	0.00909775	0.00581348	0.00253014	0.02059665	0.00178161	0.01589540	0.00722899
+N:C[C>G]A	0.00369553	0.00424260	0.00167118	0.00602396	0.00698209	0.00697617	0.00044136	0.00244138	0.00241209	0.00003210	0.00292671
+N:C[C>G]C	0.00370411	0.00750321	0.00392248	0.00356682	0.00547508	0.00617232	0.00076606	0.00154837	0.00157418	0.00020754	0.00332203
+N:C[C>G]G	0.00058562	0.00072434	0.00063441	0.00120774	0.00156220	0.00113104	0.00004850	0.00034938	0.00029311	0.00008939	0.00089391
+N:C[C>G]T	0.00329670	0.01305142	0.00432220	0.00453308	0.00750389	0.01217099	0.00089777	0.00314512	0.00155558	0.00016637	0.00425334
+N:C[C>T]A	0.02307083	0.00577236	0.00874859	0.00690743	0.01330700	0.00890797	0.00189618	0.00443722	0.00235797	0.00451844	0.00733212
+N:C[C>T]C	0.02489835	0.00407371	0.01203420	0.00448532	0.00972197	0.00479363	0.00242844	0.00242723	0.00266544	0.00571730	0.00668379
+N:C[C>T]G	0.00531262	0.00260813	0.00136784	0.00118210	0.00451875	0.00280379	0.00119503	0.00183794	0.00062841	0.01259393	0.06784277
+N:C[C>T]T	0.02638975	0.00240028	0.01753991	0.01964533	0.01223666	0.00418857	0.00235460	0.00137210	0.00212172	0.00837824	0.00981922
+N:C[T>A]A	0.00001844	0.00000000	0.00000000	0.00000196	0.00235072	0.00002276	0.08122913	0.00030048	0.09282475	0.00007633	0.00006003
+N:C[T>A]C	0.00284666	0.00260748	0.00556713	0.00636256	0.00349484	0.00484267	0.03699852	0.00321348	0.01471633	0.00221372	0.00156518
+N:C[T>A]G	0.00351985	0.00070970	0.00128997	0.00199047	0.00463364	0.00194066	0.11882079	0.00150935	0.03890362	0.00017945	0.00128361
+N:C[T>A]T	0.00479067	0.00298812	0.00430240	0.00965900	0.00406130	0.00639436	0.04286424	0.00407172	0.01942926	0.00139526	0.00372749
+N:C[T>C]A	0.00251784	0.00527781	0.01125821	0.00164017	0.01177738	0.00519935	0.00311622	0.00219295	0.00675038	0.01403521	0.00150469
+N:C[T>C]C	0.00179414	0.00178947	0.00425823	0.00349112	0.00985247	0.00704869	0.00079780	0.00255440	0.00004475	0.00656328	0.00197816
+N:C[T>C]G	0.00364849	0.00199411	0.00796186	0.00268022	0.01188570	0.00480736	0.00105033	0.00187189	0.00188255	0.01250875	0.00244319
+N:C[T>C]T	0.00271734	0.00344837	0.00746842	0.00167014	0.01174937	0.00885635	0.00110323	0.00345265	0.00081612	0.01135508	0.00213849
+N:C[T>G]A	0.00036884	0.00287542	0.00079743	0.00097348	0.00203083	0.00347799	0.00170608	0.00078974	0.00555473	0.00061818	0.00125699
+N:C[T>G]C	0.00041261	0.00681087	0.00187854	0.00070338	0.00297529	0.00266458	0.00069539	0.00150620	0.00133861	0.00174821	0.00065364
+N:C[T>G]G	0.00081729	0.00415215	0.00153855	0.00352945	0.00380826	0.00497173	0.00261258	0.00112985	0.00511983	0.00117531	0.00155744
+N:C[T>G]T	0.00025042	0.01177401	0.00262030	0.00075140	0.00528691	0.00916872	0.00053912	0.00311043	0.00171665	0.00195635	0.00262922
+N:G[C>A]A	0.00691639	0.00015151	0.00030626	0.00841380	0.01110892	0.00333147	0.00136604	0.05649086	0.00139391	0.00109748	0.00433987
+N:G[C>A]C	0.00843716	0.00186032	0.00227755	0.01537150	0.00549559	0.00239688	0.00184864	0.01325407	0.00101079	0.00221676	0.00113481
+N:G[C>A]G	0.00327207	0.00016079	0.00029626	0.00204980	0.00090950	0.00015774	0.00027851	0.00424022	0.00034563	0.00052352	0.00043840
+N:G[C>A]T	0.00313532	0.00096573	0.00239067	0.01178400	0.00479094	0.00459036	0.00138990	0.03413772	0.00103035	0.00249177	0.00306205
+N:G[C>G]A	0.00326422	0.00081421	0.00154852	0.00604719	0.00339463	0.00541605	0.00051199	0.00066839	0.00116820	0.00044881	0.00211625
+N:G[C>G]C	0.00327617	0.00179575	0.00247379	0.00521214	0.00336013	0.00441353	0.00013602	0.00051160	0.00176071	0.00088669	0.00086431
+N:G[C>G]G	0.00081537	0.00027580	0.00067883	0.00129919	0.00059804	0.00049117	0.00004606	0.00026886	0.00032330	0.00019932	0.00010206
+N:G[C>G]T	0.00269925	0.00381846	0.00155414	0.00560622	0.00407751	0.00694884	0.00060763	0.00242335	0.00038123	0.00080180	0.00062712
+N:G[C>T]A	0.02468455	0.00327549	0.00666075	0.00245816	0.00704668	0.00702404	0.00031718	0.00589833	0.00191292	0.01832794	0.00756887
+N:G[C>T]C	0.02242601	0.00025156	0.00917936	0.00351214	0.00415204	0.00358066	0.00057122	0.00377828	0.00190464	0.02044476	0.00582812
+N:G[C>T]G	0.00728563	0.00028272	0.00127418	0.00042820	0.00129983	0.00326108	0.00051050	0.00217033	0.00144679	0.02452920	0.07943851
+N:G[C>T]T	0.01988875	0.00153217	0.01205340	0.01028118	0.00590328	0.00113070	0.00033056	0.00228240	0.00267174	0.01724059	0.00578358
+N:G[T>A]A	0.00133511	0.00201190	0.00164393	0.00277748	0.00001283	0.00056218	0.03413541	0.00069443	0.03202838	0.00165849	0.00071379
+N:G[T>A]C	0.00165469	0.00207091	0.00177139	0.00282134	0.00193174	0.00204568	0.00648240	0.00141328	0.00295651	0.00276601	0.00078721
+N:G[T>A]G	0.00286332	0.00354277	0.00171221	0.00420198	0.00299477	0.00091560	0.02371329	0.00273871	0.00089066	0.00130181	0.00145789
+N:G[T>A]T	0.00247371	0.00256317	0.00306326	0.00736993	0.00122521	0.00361142	0.00694533	0.00366002	0.00291246	0.00247977	0.00154593
+N:G[T>C]A	0.00121957	0.00444900	0.00009204	0.00096884	0.01562135	0.00317268	0.00052290	0.00327747	0.00453644	0.03274371	0.00056199
+N:G[T>C]C	0.00161848	0.00040474	0.00048987	0.00134276	0.00914244	0.00435302	0.00017816	0.00163303	0.00071846	0.00803886	0.00084950
+N:G[T>C]G	0.00197691	0.00230271	0.00068049	0.00118444	0.01092706	0.00448760	0.00079230	0.00137410	0.00048681	0.01527125	0.00163030
+N:G[T>C]T	0.00601550	0.00124305	0.00064862	0.00085077	0.01229228	0.00693616	0.00031314	0.00342983	0.00107437	0.02021566	0.00162763
+N:G[T>G]A	0.00063596	0.00225344	0.00033330	0.00056527	0.00116426	0.00252610	0.00072280	0.00069356	0.00227091	0.00001903	0.00060178
+N:G[T>G]C	0.00030497	0.00205571	0.00012345	0.00051077	0.00109806	0.00225424	0.00015913	0.00017353	0.00016197	0.00029670	0.00034427
+N:G[T>G]G	0.00140929	0.00193373	0.00124723	0.00219570	0.00224959	0.00241098	0.00078458	0.00123975	0.00042239	0.00016641	0.00137842
+N:G[T>G]T	0.00042845	0.00517670	0.00050497	0.00097093	0.00208170	0.00443690	0.00009536	0.00089345	0.00044754	0.00098813	0.00234397
+N:T[C>A]A	0.01596943	0.01127141	0.00533040	0.02118665	0.00735637	0.01478240	0.00322155	0.04731808	0.00330268	0.00252880	0.00401551
+N:T[C>A]C	0.02192088	0.00771679	0.00323989	0.02352964	0.00545615	0.01199709	0.00330645	0.02861170	0.00313971	0.00290902	0.00226865
+N:T[C>A]G	0.00444971	0.00066354	0.00043824	0.00112069	0.00089807	0.00154643	0.00027726	0.00506876	0.00062880	0.00005462	0.00059160
+N:T[C>A]T	0.00931050	0.00475388	0.00839327	0.02083963	0.00162180	0.02391401	0.00272559	0.07178193	0.00311634	0.00607492	0.00758415
+N:T[C>G]A	0.00689488	0.00207179	0.00096844	0.00662653	0.00458914	0.03093228	0.00073565	0.00785500	0.00351598	0.00171395	0.00159104
+N:T[C>G]C	0.00641073	0.00932548	0.00467301	0.00642291	0.00682882	0.01625370	0.00100282	0.00494671	0.00319217	0.00060934	0.00250101
+N:T[C>G]G	0.00070222	0.00066565	0.00096615	0.00154967	0.00087033	0.00138814	0.00014469	0.00010511	0.00031112	0.00024964	0.00015166
+N:T[C>G]T	0.00900341	0.01156004	0.00299610	0.00779180	0.00820149	0.05378470	0.00118697	0.01456292	0.00305977	0.00210751	0.00404005
+N:T[C>T]A	0.02756676	0.01124478	0.01040491	0.00737800	0.00598882	0.03230704	0.00109298	0.01351923	0.00370984	0.00803789	0.00601421
+N:T[C>T]C	0.03547226	0.00440782	0.00947284	0.00350931	0.00770681	0.01780959	0.00165650	0.01222432	0.00312607	0.00605535	0.00755964
+N:T[C>T]G	0.00563887	0.00199014	0.00164930	0.00038648	0.00162968	0.00261246	0.00027309	0.00282633	0.00098351	0.00919357	0.05128821
+N:T[C>T]T	0.02423223	0.00180973	0.01544825	0.01342779	0.00519286	0.01980241	0.00098527	0.01175015	0.00318424	0.00857620	0.00735780
+N:T[T>A]A	0.00115167	0.00681188	0.00429994	0.00385970	0.00021228	0.00606931	0.04407619	0.00355264	0.10305963	0.00451612	0.00290531
+N:T[T>A]C	0.00145781	0.00951165	0.00772938	0.00696181	0.00378585	0.00588859	0.01674573	0.00612350	0.00928798	0.00351612	0.00083060
+N:T[T>A]G	0.00265372	0.00522765	0.00339701	0.00176396	0.00317520	0.00100238	0.04796662	0.00139943	0.03969619	0.00066460	0.00104578
+N:T[T>A]T	0.00308073	0.02315431	0.01462836	0.01929230	0.00050304	0.00717608	0.02063152	0.00814754	0.03029761	0.00575723	0.00333678
+N:T[T>C]A	0.00009103	0.00759858	0.00638436	0.00185094	0.02243094	0.00338049	0.00157993	0.00344845	0.01955741	0.03327960	0.00190871
+N:T[T>C]C	0.00010669	0.00082537	0.00123674	0.00422142	0.01196385	0.01148942	0.00012597	0.00370069	0.00096268	0.01120301	0.00038555
+N:T[T>C]G	0.00213433	0.00238429	0.00180861	0.00086955	0.01391306	0.00334399	0.00038447	0.00273592	0.00429486	0.01324838	0.00121063
+N:T[T>C]T	0.00263449	0.00394161	0.00262904	0.00306834	0.01703715	0.00845904	0.00021590	0.00377726	0.00281812	0.02827046	0.00152297
+N:T[T>G]A	0.00208082	0.00959003	0.00186157	0.00076326	0.00311727	0.00731554	0.00088139	0.00321380	0.01027179	0.00097198	0.00107852
+N:T[T>G]C	0.00213110	0.01693302	0.00291077	0.00087676	0.00432757	0.00403808	0.00091288	0.00231624	0.00105674	0.00108920	0.00089539
+N:T[T>G]G	0.00138222	0.00897005	0.00350562	0.00382416	0.00321246	0.00707710	0.00170688	0.00227544	0.00570817	0.00083023	0.00183850
+N:T[T>G]T	0.00388434	0.03204407	0.00750545	0.00138201	0.00807450	0.01271037	0.00101438	0.00606568	0.00314996	0.00277034	0.00399355
diff --git a/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_SBS96.txt b/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_SBS96.txt
new file mode 100644
index 0000000..9d2db4e
--- /dev/null
+++ b/SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_SBS96.txt
@@ -0,0 +1,97 @@
+MutationType	SBS96A	SBS96B	SBS96C	SBS96D	SBS96E	SBS96F	SBS96G	SBS96H	SBS96I	SBS96J
+A[C>A]A	0.00218357	0.02474735	0.01942135	0.00621499	0.03096854	0.00625659	0.02489127	0.02539419	0.01473679	0.02051796
+A[C>A]C	0.00008572	0.01786941	0.02612239	0.00778057	0.01723222	0.01424730	0.01177015	0.00811465	0.01562104	0.03620289
+A[C>A]G	0.00013038	0.00527876	0.00581474	0.00042457	0.00003345	0.00000000	0.00549106	0.00501512	0.00426970	0.00181109
+A[C>A]T	0.00040721	0.02083877	0.02612001	0.00646572	0.01825382	0.00332662	0.01300422	0.01390875	0.00747643	0.02756017
+A[C>G]A	0.00238632	0.01200257	0.02210225	0.01812694	0.00180942	0.00887732	0.00710678	0.00991958	0.01759181	0.00514893
+A[C>G]C	0.00066455	0.01015710	0.01282159	0.01059326	0.00584033	0.00728989	0.00752939	0.00811556	0.00388515	0.00390022
+A[C>G]G	0.00013152	0.00181592	0.01540621	0.00291876	0.00223095	0.00239903	0.00000000	0.00189748	0.00116926	0.00000000
+A[C>G]T	0.00184659	0.00822399	0.01917484	0.02339320	0.00800459	0.00345073	0.00834785	0.00822053	0.01041648	0.01444799
+A[C>T]A	0.00417547	0.01224507	0.02057816	0.00214091	0.02936919	0.02493605	0.01556834	0.02246833	0.01195646	0.03217214
+A[C>T]C	0.00127702	0.00439746	0.00829266	0.01044989	0.00784618	0.01017706	0.01363935	0.01027530	0.00621361	0.01715381
+A[C>T]G	0.00207642	0.00349272	0.00000000	0.00338379	0.02986476	0.05709594	0.10002064	0.04140436	0.03567427	0.00692162
+A[C>T]T	0.00190244	0.01914102	0.02310231	0.00862452	0.00496679	0.01425636	0.01972298	0.01614130	0.00397516	0.00550852
+A[T>A]A	0.00118054	0.01819910	0.00235041	0.00759470	0.00420469	0.00932572	0.00242991	0.00994616	0.02263582	0.00907194
+A[T>A]C	0.00071747	0.01367841	0.00669493	0.00763198	0.01150742	0.00448623	0.00827621	0.00812199	0.00839992	0.00947493
+A[T>A]G	0.00042465	0.01883384	0.01063346	0.00377729	0.00436834	0.01085813	0.00707141	0.00658812	0.01093292	0.01133973
+A[T>A]T	0.00015326	0.02331144	0.01062365	0.00629120	0.00688102	0.03152807	0.00557022	0.00728340	0.02654590	0.02322737
+A[T>C]A	0.00050062	0.02280217	0.01156063	0.01141813	0.02043426	0.02640561	0.00794646	0.01258185	0.02144971	0.02694482
+A[T>C]C	0.00017972	0.00632694	0.01641440	0.00926998	0.00735091	0.00498589	0.01079117	0.00727141	0.00260213	0.01144453
+A[T>C]G	0.00087147	0.01514559	0.00783777	0.01789041	0.01279564	0.01157341	0.01282303	0.01355681	0.01216524	0.00730773
+A[T>C]T	0.00045851	0.01821582	0.01423373	0.02294103	0.02306066	0.01731143	0.02118915	0.01633541	0.01202296	0.00572319
+A[T>G]A	0.00001812	0.00530849	0.00386996	0.00431729	0.00410562	0.01032337	0.00193123	0.00302905	0.02046176	0.00052364
+A[T>G]C	0.00026968	0.00184176	0.00488509	0.00073266	0.00167364	0.00339425	0.00035499	0.00417676	0.00984339	0.00093992
+A[T>G]G	0.00004573	0.00600224	0.01387840	0.01412294	0.00044142	0.00423439	0.00000000	0.00499281	0.00448457	0.00000000
+A[T>G]T	0.00000000	0.00147432	0.00123917	0.01634112	0.00777774	0.00377135	0.00053146	0.00637439	0.01358179	0.00303104
+C[C>A]A	0.00138758	0.02321437	0.01987414	0.01366344	0.01386702	0.01022734	0.01640670	0.01521563	0.01487581	0.01453195
+C[C>A]C	0.00064612	0.02608274	0.02328029	0.00977582	0.01044530	0.00444724	0.00689462	0.00892062	0.00718958	0.01321176
+C[C>A]G	0.00029080	0.00231848	0.00660853	0.00039697	0.00104731	0.00123275	0.00274078	0.00287154	0.00486981	0.00171801
+C[C>A]T	0.00082006	0.02220895	0.02313033	0.00265305	0.01415449	0.01270963	0.00835638	0.01107852	0.00695577	0.01103071
+C[C>G]A	0.00295337	0.00896052	0.01897142	0.01181333	0.00141159	0.00644496	0.00122911	0.00692530	0.00817512	0.00586189
+C[C>G]C	0.00068394	0.01116855	0.00749283	0.00824808	0.00640740	0.00147682	0.00327706	0.00611402	0.00490861	0.00526224
+C[C>G]G	0.00044345	0.00014113	0.01091535	0.00168766	0.00000000	0.00384750	0.00000000	0.00607825	0.00196051	0.00444257
+C[C>G]T	0.00323293	0.01042758	0.01783236	0.01472134	0.00286360	0.01020045	0.00939491	0.01383341	0.00721609	0.01590090
+C[C>T]A	0.01003554	0.00938173	0.01170597	0.00032507	0.02075968	0.01365871	0.01493821	0.02064191	0.01466054	0.03074610
+C[C>T]C	0.00253876	0.01353327	0.00264827	0.00089582	0.01828302	0.01017298	0.01258096	0.00999515	0.01638771	0.02442505
+C[C>T]G	0.00432955	0.00431370	0.00532323	0.00000000	0.03423994	0.02031105	0.05053706	0.02331662	0.01274486	0.00983388
+C[C>T]T	0.00532628	0.01249624	0.02004678	0.01303893	0.02311784	0.01096328	0.02241727	0.01737133	0.00391042	0.02640987
+C[T>A]A	0.00018741	0.01407213	0.00837892	0.00546700	0.00158092	0.00497074	0.00000000	0.00668328	0.01619673	0.00379676
+C[T>A]C	0.00032220	0.01728091	0.01473364	0.00800799	0.00628585	0.00040148	0.00428062	0.00678489	0.01231904	0.01312840
+C[T>A]G	0.00013908	0.01256122	0.01230234	0.01187085	0.00763496	0.00004125	0.00504654	0.00513926	0.01564541	0.00131882
+C[T>A]T	0.00007336	0.01970828	0.02739575	0.00690544	0.00750620	0.00490004	0.00280757	0.01102288	0.00729714	0.00693517
+C[T>C]A	0.00006440	0.00947806	0.01215000	0.00723988	0.00348857	0.00991498	0.00689453	0.00852096	0.00727081	0.00853160
+C[T>C]C	0.00051396	0.01598977	0.01870108	0.00242817	0.00385365	0.00988340	0.00960146	0.01127138	0.01233543	0.00092662
+C[T>C]G	0.00091975	0.00657023	0.00596622	0.01554907	0.00819702	0.00755581	0.00514092	0.00604562	0.00928575	0.00633679
+C[T>C]T	0.00042665	0.00651236	0.00409022	0.01136824	0.01408657	0.01077777	0.00693626	0.01536416	0.00649637	0.00684036
+C[T>G]A	0.00000751	0.00012987	0.00508928	0.00560921	0.00306467	0.00367591	0.00054749	0.00423531	0.00337730	0.00774918
+C[T>G]C	0.00015878	0.00280371	0.00321603	0.00439780	0.00512732	0.00249157	0.00078563	0.00569655	0.00788608	0.00313018
+C[T>G]G	0.00010320	0.00808428	0.00983214	0.01213050	0.00248798	0.00433826	0.00520758	0.00421264	0.00633733	0.01131032
+C[T>G]T	0.00009073	0.00614831	0.00336886	0.01046332	0.01256331	0.01149545	0.00523688	0.00977792	0.01714621	0.00000000
+G[C>A]A	0.00118148	0.01345634	0.02270080	0.00119850	0.01716022	0.00912381	0.02603515	0.01831167	0.00796733	0.00321588
+G[C>A]C	0.00052071	0.01496327	0.00628284	0.00173704	0.01125567	0.00675538	0.00683156	0.01176855	0.01206335	0.01503314
+G[C>A]G	0.00021967	0.00151777	0.00085432	0.00091476	0.00178343	0.00123228	0.00474192	0.00316534	0.00146470	0.00201700
+G[C>A]T	0.00052035	0.00919805	0.01346485	0.00672000	0.01738530	0.01215343	0.01678067	0.01139853	0.00246208	0.00000000
+G[C>G]A	0.00090520	0.00535745	0.01042423	0.00774782	0.00083809	0.00053105	0.00517199	0.00370807	0.00714383	0.01473065
+G[C>G]C	0.00048566	0.00967365	0.00676105	0.00654979	0.00318712	0.00244687	0.00334684	0.00489441	0.00477723	0.00924158
+G[C>G]G	0.00019738	0.00011319	0.00504626	0.00181642	0.00009027	0.00016942	0.00043631	0.00272475	0.00200194	0.00181874
+G[C>G]T	0.00134599	0.01496610	0.01731216	0.01607536	0.00052206	0.00379560	0.00360086	0.00411285	0.00383419	0.00605748
+G[C>T]A	0.00433015	0.01247171	0.00956803	0.00761613	0.01673177	0.00795619	0.02000248	0.01211025	0.00946019	0.01852648
+G[C>T]C	0.00204614	0.00933746	0.00478986	0.00520714	0.01449463	0.01085331	0.01715374	0.01068791	0.00666133	0.02531478
+G[C>T]G	0.00280934	0.00567098	0.00626333	0.00256102	0.01942798	0.04520001	0.05330267	0.02794323	0.02500266	0.00622312
+G[C>T]T	0.00289672	0.01412904	0.01020054	0.01221431	0.01801405	0.00924711	0.01129934	0.00864439	0.00970922	0.01403647
+G[T>A]A	0.00032310	0.00747307	0.01062560	0.00301874	0.00508679	0.00211774	0.00053428	0.00440263	0.00501310	0.00394508
+G[T>A]C	0.00013678	0.01102337	0.00287266	0.00509331	0.00127745	0.00078580	0.00566342	0.00484327	0.00659658	0.00404390
+G[T>A]G	0.00034812	0.00935194	0.00769607	0.00420863	0.00099287	0.00036867	0.00279094	0.00521211	0.00761421	0.00595764
+G[T>A]T	0.00001813	0.01340881	0.01486659	0.00766869	0.00517164	0.00466894	0.00000000	0.00658045	0.00645595	0.01463448
+G[T>C]A	0.00027077	0.00876558	0.00755023	0.00956115	0.00708896	0.00964291	0.01198745	0.00470733	0.01488569	0.00669244
+G[T>C]C	0.00031468	0.00490890	0.00886432	0.00372477	0.00626436	0.00536222	0.00438391	0.00577392	0.00904122	0.00901277
+G[T>C]G	0.00055534	0.00712820	0.00951843	0.00941126	0.00320767	0.00461104	0.00312549	0.00940279	0.00646435	0.00524880
+G[T>C]T	0.00021667	0.00964665	0.00397220	0.00621176	0.01534786	0.01589286	0.00645139	0.00719788	0.01494741	0.01144694
+G[T>G]A	0.00008257	0.00125291	0.00602056	0.00802259	0.00220205	0.00000000	0.00125829	0.00179296	0.00903719	0.00335144
+G[T>G]C	0.00023699	0.00487861	0.00242186	0.00394792	0.00191885	0.00034424	0.00169440	0.00210771	0.00225347	0.00153066
+G[T>G]G	0.00101221	0.00896077	0.01084423	0.00676653	0.00826901	0.00071036	0.00000000	0.00849412	0.01059955	0.00603798
+G[T>G]T	0.00033066	0.00299922	0.00852897	0.00715778	0.00981191	0.00043338	0.00398817	0.00559770	0.01017798	0.00165781
+T[C>A]A	0.02668681	0.02637623	0.00886784	0.01531181	0.01926634	0.01952910	0.03052966	0.01482507	0.00702916	0.02037966
+T[C>A]C	0.01044032	0.01002586	0.01289902	0.02063653	0.01658120	0.01584005	0.01847292	0.01289446	0.01175355	0.01574699
+T[C>A]G	0.00173018	0.00198717	0.00089584	0.00000000	0.00501104	0.00245537	0.00161087	0.00542684	0.00221599	0.00252389
+T[C>A]T	0.01415837	0.03039420	0.00629158	0.01782898	0.02211631	0.03862296	0.04094483	0.01668674	0.01054832	0.01126722
+T[C>G]A	0.15446975	0.00409310	0.00000000	0.09681813	0.00000000	0.00000000	0.00774201	0.01946793	0.00484058	0.02924098
+T[C>G]C	0.03021046	0.00770435	0.00993228	0.04048829	0.00212407	0.02040845	0.02139050	0.01806721	0.00605730	0.01235292
+T[C>G]G	0.00537327	0.00000000	0.00600675	0.00585138	0.00303731	0.00000000	0.00000000	0.00471855	0.00000000	0.00005819
+T[C>G]T	0.19249468	0.00909779	0.00363829	0.15869853	0.01876348	0.02095192	0.00643679	0.02124738	0.00100048	0.05150326
+T[C>T]A	0.26696155	0.02802040	0.00520307	0.01129031	0.04301460	0.02058525	0.00246600	0.02835125	0.04373599	0.00734479
+T[C>T]C	0.05239144	0.00623012	0.00000000	0.00000000	0.03603685	0.03198812	0.02217155	0.02978497	0.01915660	0.02772426
+T[C>T]G	0.02753098	0.00000000	0.00245838	0.00000000	0.01379397	0.03218888	0.03756412	0.02020548	0.02243882	0.00599424
+T[C>T]T	0.13559820	0.01226640	0.01181764	0.00680926	0.03578362	0.03726973	0.01474596	0.02565185	0.01770994	0.02254420
+T[T>A]A	0.00036023	0.01224464	0.00335891	0.00484581	0.01352993	0.04032272	0.01246840	0.01232218	0.02229553	0.01010909
+T[T>A]C	0.00015380	0.01336975	0.00875501	0.00447439	0.00302181	0.00624440	0.00380218	0.00639451	0.00407624	0.01096401
+T[T>A]G	0.00013444	0.00389344	0.01007438	0.00291879	0.00543155	0.00341768	0.00388563	0.00467470	0.00462176	0.00663648
+T[T>A]T	0.00017394	0.01818479	0.03213828	0.00372648	0.01234810	0.01686356	0.00328610	0.00842069	0.01063711	0.02118619
+T[T>C]A	0.00031785	0.01319246	0.00602967	0.00593890	0.01113461	0.01503534	0.01043934	0.00414447	0.01467457	0.00830771
+T[T>C]C	0.00041509	0.00712143	0.01466503	0.00543123	0.00239049	0.01322473	0.01205419	0.00407401	0.01860633	0.00657803
+T[T>C]G	0.00030883	0.00415937	0.00611292	0.00428252	0.00958774	0.00712092	0.00694299	0.00369950	0.00501961	0.00108679
+T[T>C]T	0.00038699	0.00890602	0.01109863	0.01088086	0.01930472	0.01369190	0.01133192	0.01041280	0.01054649	0.00617200
+T[T>G]A	0.00016584	0.00423749	0.00405603	0.01044511	0.00617789	0.00438819	0.00364306	0.00424205	0.00774998	0.00201051
+T[T>G]C	0.00004913	0.00469704	0.00720394	0.00555849	0.00544036	0.00378904	0.00166520	0.00549857	0.00345131	0.00016733
+T[T>G]G	0.00000000	0.00892399	0.00994223	0.00678590	0.00484364	0.00146394	0.00322513	0.01224009	0.01594934	0.00530278
+T[T>G]T	0.00040064	0.00928431	0.01487221	0.01432406	0.02023451	0.01354506	0.00533357	0.01271542	0.01668954	0.01126987
diff --git a/SigProfilerAssignment/DecompositionPlots/ExampleSample/Decomposed_Solution_Signatures_SBS1536.txt b/SigProfilerAssignment/DecompositionPlots/ExampleSample/Decomposed_Solution_Signatures_SBS1536.txt
new file mode 100644
index 0000000..eb87d0b
--- /dev/null
+++ b/SigProfilerAssignment/DecompositionPlots/ExampleSample/Decomposed_Solution_Signatures_SBS1536.txt
@@ -0,0 +1,97 @@
+MutationType	SBS1	SBS2	SBS5	SBS13	SBS15	SBS17a	SBS17b	SBS18	SBS20	SBS40	SBS41
+A[C>A]A	0.00089628	0.00000058	0.01194370	0.00182303	0.00094231	0.00206780	0.00060815	0.05138118	0.00061437	0.02808571	0.00210048
+A[C>A]C	0.00234181	0.00015054	0.00953978	0.00073328	0.00050372	0.00093109	0.00013101	0.01600527	0.00140075	0.01355033	0.00123312
+A[C>A]G	0.00017436	0.00005102	0.00179309	0.00025751	0.00004481	0.00004630	0.00005669	0.00236090	0.00002107	0.00283200	0.00005952
+A[C>A]T	0.00129516	0.00009800	0.00658059	0.00034866	0.00110828	0.00006175	0.00045622	0.02135583	0.00123102	0.01474361	0.00132432
+A[C>G]A	0.00188157	0.00000000	0.01005261	0.00387645	0.00011280	0.00100893	0.00014604	0.00172601	0.00870437	0.01215055	0.00530595
+A[C>G]C	0.00125308	0.00013528	0.00576025	0.00096719	0.00027264	0.00057711	0.00004408	0.00262365	0.00152168	0.00877738	0.00319398
+A[C>G]G	0.00011329	0.00001483	0.00166709	0.00025751	0.00002984	0.00014786	0.00000000	0.00186540	0.00045330	0.00218219	0.00117299
+A[C>G]T	0.00115350	0.00009139	0.01005506	0.00400764	0.00032450	0.00001958	0.00031916	0.00407158	0.00438799	0.01454437	0.00823469
+A[C>T]A	0.02528997	0.00006121	0.03244704	0.00719196	0.00504096	0.00121871	0.00057114	0.00917877	0.04893104	0.01962016	0.00983542
+A[C>T]C	0.00649134	0.00140371	0.01808921	0.00000000	0.00700340	0.00173438	0.00007140	0.00471041	0.01310056	0.01223575	0.00339613
+A[C>T]G	0.35956302	0.00003190	0.00598990	0.00029556	0.07241886	0.00003842	0.00027955	0.01185306	0.01285473	0.00025895	0.00332509
+A[C>T]T	0.00969348	0.00186383	0.02190211	0.00031861	0.00177725	0.00073640	0.00014707	0.00795355	0.01290585	0.01683561	0.00632289
+A[T>A]A	0.00081666	0.00009695	0.00741241	0.00000000	0.00205493	0.00101814	0.00006319	0.00250693	0.00051180	0.00613072	0.00749411
+A[T>A]C	0.00225944	0.00088099	0.00690842	0.00006541	0.00084082	0.00099752	0.00028953	0.00087736	0.00515932	0.00442901	0.00428738
+A[T>A]G	0.00116316	0.00002577	0.00915544	0.00059608	0.00054368	0.00020151	0.00006628	0.00261636	0.00030332	0.00696140	0.00304232
+A[T>A]T	0.00018662	0.00000000	0.00622074	0.00061191	0.00959981	0.00147023	0.00063827	0.00788507	0.02561357	0.01074268	0.06984539
+A[T>C]A	0.00111271	0.00006238	0.04640289	0.00193064	0.00391847	0.00009728	0.00009821	0.00203373	0.01071684	0.01879418	0.01446585
+A[T>C]C	0.00308013	0.00002157	0.01335826	0.00014246	0.00195959	0.01270664	0.00025246	0.00208848	0.00452310	0.00732184	0.00577301
+A[T>C]G	0.00010815	0.00001334	0.03834845	0.00043241	0.00024163	0.00037884	0.00000000	0.00209309	0.01861990	0.01557022	0.00807270
+A[T>C]T	0.00585346	0.00015654	0.03842810	0.00096835	0.00093482	0.00784457	0.00054853	0.00426437	0.00010305	0.01947738	0.01776240
+A[T>G]A	0.00017558	0.00024061	0.00387695	0.00006206	0.00047143	0.00085786	0.00142322	0.00072590	0.00001052	0.00726641	0.00756443
+A[T>G]C	0.00020973	0.00007485	0.00259190	0.00000000	0.00041491	0.00070037	0.00448820	0.00085738	0.00002117	0.00703255	0.00163519
+A[T>G]G	0.00027345	0.00000207	0.00797086	0.00008335	0.00018626	0.00072443	0.00099878	0.00200252	0.00002693	0.00809652	0.00271098
+A[T>G]T	0.00011421	0.00000380	0.00484615	0.00032312	0.00365276	0.01258757	0.06967498	0.00185058	0.00005823	0.01807180	0.00763683
+C[C>A]A	0.00031909	0.00021067	0.00747649	0.00141776	0.04218415	0.00029793	0.00027405	0.07464142	0.03772912	0.02094358	0.00239532
+C[C>A]C	0.00184352	0.00009720	0.00622173	0.00098715	0.00513214	0.00117973	0.00004185	0.01990849	0.09993538	0.01490524	0.00093140
+C[C>A]G	0.00009447	0.00000000	0.00345075	0.00000435	0.00006622	0.00000000	0.00000000	0.01199659	0.00738935	0.00253484	0.00026035
+C[C>A]T	0.00000000	0.00042651	0.00653222	0.00000000	0.02897092	0.00013839	0.00018409	0.03662370	0.25292798	0.01480513	0.00266772
+C[C>G]A	0.00002465	0.00000000	0.00700355	0.00568116	0.00008437	0.00055849	0.00019618	0.00061831	0.00007716	0.00761219	0.00209339
+C[C>G]C	0.00007910	0.00035800	0.00919073	0.00066082	0.00001728	0.00023900	0.00004745	0.00229557	0.00000443	0.00948054	0.00121619
+C[C>G]G	0.00035680	0.00004889	0.00248334	0.00048980	0.00005021	0.00023222	0.00000000	0.00357898	0.00018697	0.00167658	0.00040998
+C[C>G]T	0.00000000	0.00006443	0.00959200	0.00648279	0.00008530	0.00003940	0.00019522	0.00382380	0.00001014	0.01399941	0.00506364
+C[C>T]A	0.00204545	0.00437545	0.01952138	0.00001954	0.01089925	0.00082915	0.00046214	0.01180141	0.01063640	0.01973530	0.00695449
+C[C>T]C	0.00027807	0.00017339	0.01925292	0.00137671	0.01128054	0.00174925	0.00005998	0.00686640	0.01313610	0.01754154	0.00187496
+C[C>T]G	0.19867546	0.00278066	0.01745321	0.00199736	0.02480579	0.00190183	0.00054423	0.01679523	0.01640972	0.00235520	0.01007481
+C[C>T]T	0.00020050	0.00146898	0.02325028	0.00146876	0.01574726	0.00175771	0.00013756	0.00670930	0.01174308	0.02175448	0.00778169
+C[T>A]A	0.00004376	0.00024488	0.00354418	0.00021058	0.00034943	0.00043610	0.00009418	0.00054394	0.00014377	0.00109199	0.00362493
+C[T>A]C	0.00039864	0.00024511	0.00517973	0.00034350	0.00024423	0.04056730	0.00224665	0.00306126	0.00644903	0.00760980	0.00318426
+C[T>A]G	0.00032969	0.00015015	0.00501588	0.00022771	0.00008234	0.01245985	0.00072140	0.00322147	0.00012280	0.00346629	0.00312423
+C[T>A]T	0.00026286	0.00000000	0.00427725	0.00052356	0.00104749	0.07217983	0.00778721	0.00225343	0.00010118	0.00923682	0.00896394
+C[T>C]A	0.00000000	0.00030433	0.01331570	0.00004776	0.00075307	0.01115365	0.00065098	0.00038738	0.01168096	0.01091988	0.01031402
+C[T>C]C	0.00253589	0.00002863	0.01037941	0.00012254	0.00215200	0.17328748	0.00647919	0.00246101	0.00480692	0.00985679	0.00524055
+C[T>C]G	0.00036632	0.00000000	0.02082442	0.00000000	0.00139569	0.08772138	0.00394407	0.00162579	0.02605734	0.01051908	0.00557754
+C[T>C]T	0.00004307	0.00018623	0.01482116	0.00011212	0.00174581	0.42529195	0.01829345	0.00255256	0.00684424	0.01353672	0.00782977
+C[T>G]A	0.00003612	0.00015418	0.00259306	0.00004171	0.00020684	0.00031150	0.00206260	0.00011140	0.00096143	0.00335611	0.00347472
+C[T>G]C	0.00021504	0.00015570	0.00460087	0.00000283	0.00015715	0.00104173	0.03149327	0.00199082	0.00159235	0.00566241	0.00240566
+C[T>G]G	0.00013025	0.00012193	0.00613720	0.00000000	0.00027311	0.00000195	0.01378411	0.00294047	0.00270557	0.00560016	0.00304412
+C[T>G]T	0.00017288	0.00020325	0.00726137	0.00005556	0.00248404	0.00530117	0.54980315	0.00412796	0.00506870	0.01303905	0.01044633
+G[C>A]A	0.00160430	0.00008668	0.01019009	0.00095413	0.00229444	0.00178476	0.00100198	0.10915499	0.01075924	0.01419531	0.00308755
+G[C>A]C	0.00034901	0.00000000	0.00774909	0.00045976	0.00252961	0.00130131	0.00000283	0.01756608	0.00570713	0.01033876	0.00073250
+G[C>A]G	0.00059137	0.00001387	0.00231944	0.00016360	0.00040162	0.00010545	0.00009204	0.00751152	0.00155184	0.00252922	0.00021811
+G[C>A]T	0.00000000	0.00005175	0.00684830	0.00006215	0.01832879	0.00004737	0.00053888	0.06270841	0.00249332	0.01085178	0.00195844
+G[C>G]A	0.00000974	0.00006576	0.00467545	0.00150812	0.00099593	0.00088035	0.00006014	0.00063590	0.00066648	0.00505833	0.00203839
+G[C>G]C	0.00016884	0.00026611	0.00514580	0.00048830	0.00061767	0.00084890	0.00005650	0.00136061	0.00288892	0.00544305	0.00272534
+G[C>G]G	0.00016723	0.00000000	0.00149673	0.00024041	0.00001004	0.00002358	0.00000000	0.00063490	0.00068400	0.00118030	0.00015466
+G[C>G]T	0.00000000	0.00013544	0.00674788	0.00272852	0.00045419	0.00079315	0.00000000	0.00123806	0.00302402	0.00701346	0.00357542
+G[C>T]A	0.00450829	0.00000000	0.01938115	0.00721884	0.07384301	0.00164438	0.00006134	0.00969376	0.04204073	0.01429528	0.00600524
+G[C>T]C	0.00009554	0.00000013	0.02187979	0.00093889	0.13105191	0.00000000	0.00015982	0.00829566	0.05373796	0.01175780	0.00875350
+G[C>T]G	0.21962122	0.00000000	0.01219192	0.00017756	0.27536635	0.00160168	0.00085169	0.01470510	0.02026287	0.00000000	0.01695280
+G[C>T]T	0.00003919	0.00005094	0.01867718	0.00128342	0.07774632	0.00006652	0.00000000	0.00673386	0.03314411	0.01276089	0.00844642
+G[T>A]A	0.00008310	0.00000000	0.00369558	0.00000679	0.00051606	0.00006529	0.00009846	0.00161501	0.00005583	0.00267018	0.00234666
+G[T>A]C	0.00013173	0.00013248	0.00292382	0.00013145	0.00059352	0.00342861	0.00035038	0.00196395	0.00256494	0.00344850	0.00230129
+G[T>A]G	0.00024910	0.00006398	0.00409481	0.00004713	0.00018685	0.00069496	0.00024130	0.00182761	0.00211617	0.00439652	0.00142497
+G[T>A]T	0.00025881	0.00006239	0.00317805	0.00035559	0.00083147	0.00475475	0.00156715	0.00342310	0.00423207	0.00569848	0.00446192
+G[T>C]A	0.00107462	0.00000000	0.01419826	0.00029085	0.01302776	0.00012431	0.00006021	0.00071464	0.00277144	0.00605577	0.00610333
+G[T>C]C	0.00194027	0.00002771	0.00797770	0.00018403	0.01168905	0.01502537	0.00151460	0.00227617	0.00226436	0.00460470	0.00375844
+G[T>C]G	0.00118476	0.00010730	0.01494456	0.00019552	0.00594529	0.00356978	0.00101126	0.00397479	0.00403365	0.00563273	0.00349766
+G[T>C]T	0.00007152	0.00001242	0.01352151	0.00000000	0.00580051	0.00519060	0.00145804	0.00311641	0.00091334	0.00721939	0.00384001
+G[T>G]A	0.00000000	0.00021183	0.00253756	0.00008888	0.00020501	0.00050027	0.00028436	0.00087816	0.00000000	0.00250896	0.00181287
+G[T>G]C	0.00000000	0.00013451	0.00171812	0.00000000	0.00058445	0.00020572	0.00631082	0.00003726	0.00006663	0.00225208	0.00095468
+G[T>G]G	0.00035239	0.00003720	0.00528041	0.00042714	0.00034673	0.00083495	0.00148184	0.00582237	0.00008644	0.00443640	0.00119578
+G[T>G]T	0.00001465	0.00000000	0.00231938	0.00000287	0.00137589	0.00717175	0.11307279	0.00211718	0.00350376	0.00541208	0.00342541
+T[C>A]A	0.00006656	0.00064008	0.00782217	0.07912197	0.01716711	0.00018978	0.00001240	0.07362075	0.00169700	0.02589146	0.00329466
+T[C>A]C	0.00256283	0.00017054	0.00913939	0.02948905	0.00580749	0.00002591	0.00000000	0.04355859	0.00334933	0.02094334	0.00171457
+T[C>A]G	0.00000000	0.00008414	0.00225400	0.01193373	0.00007558	0.00000000	0.00009366	0.01247580	0.00000000	0.00310859	0.00020290
+T[C>A]T	0.00000592	0.00043888	0.01258549	0.03540465	0.00800067	0.00028644	0.00255946	0.12118968	0.00089334	0.02389804	0.00584786
+T[C>G]A	0.00000000	0.00000000	0.00777241	0.31748943	0.00021359	0.00374557	0.00016002	0.00213480	0.00012802	0.01244782	0.01980779
+T[C>G]C	0.00020563	0.00009901	0.00757463	0.06369234	0.00006117	0.00072322	0.00006190	0.00463559	0.00002803	0.01406196	0.01415516
+T[C>G]G	0.00006913	0.00004064	0.00167580	0.01361037	0.00005740	0.00037376	0.00001527	0.00088313	0.00012118	0.00170629	0.00189174
+T[C>G]T	0.00157124	0.00117701	0.01238729	0.36800888	0.00017293	0.00028147	0.00149385	0.00315888	0.00110679	0.02350139	0.04420584
+T[C>T]A	0.00112274	0.53690800	0.02020229	0.00694070	0.02644932	0.00053137	0.00010801	0.01137231	0.00800863	0.02987477	0.01164578
+T[C>T]C	0.00003778	0.09760935	0.02292323	0.00449357	0.00955587	0.00009063	0.00060497	0.01138917	0.00913363	0.02303768	0.00644957
+T[C>T]G	0.10956424	0.04359916	0.01558197	0.00117365	0.02083652	0.00017409	0.00006146	0.01159169	0.00257994	0.00207893	0.00482246
+T[C>T]T	0.00000000	0.29923905	0.02081065	0.00141619	0.00172934	0.00034612	0.00089133	0.00372509	0.00004941	0.02221228	0.01139837
+T[T>A]A	0.00692145	0.00043045	0.00639450	0.00030188	0.00110782	0.00012103	0.00121192	0.01097084	0.01212658	0.00723012	0.08169403
+T[T>A]C	0.00000000	0.00018977	0.00406534	0.00022927	0.00015462	0.00561763	0.00023881	0.00268719	0.00031139	0.01012074	0.01404464
+T[T>A]G	0.00002827	0.00005009	0.00475779	0.00018793	0.00014843	0.00182433	0.00000000	0.00178222	0.00017433	0.00498945	0.00922920
+T[T>A]T	0.00227982	0.00020571	0.00872320	0.00006220	0.00047493	0.00198114	0.00131246	0.00709521	0.00667068	0.02094912	0.05334574
+T[T>C]A	0.00026264	0.00000000	0.01824103	0.00002254	0.00347590	0.00212571	0.00107952	0.00182847	0.01394556	0.01034322	0.06446328
+T[T>C]C	0.00338335	0.00004299	0.00953489	0.00002461	0.00583018	0.01507889	0.00108552	0.00608309	0.01625490	0.00741860	0.02632142
+T[T>C]G	0.00041997	0.00011697	0.01261460	0.00009976	0.00131495	0.00234271	0.00120782	0.00324584	0.01188587	0.00597342	0.02036582
+T[T>C]T	0.00438739	0.00003592	0.01844333	0.00053276	0.00134979	0.02101206	0.00100188	0.00336773	0.01918691	0.01017528	0.04596708
+T[T>G]A	0.00000000	0.00001703	0.00528990	0.00018766	0.00023478	0.00000000	0.00001242	0.00070701	0.00000000	0.00857879	0.04246873
+T[T>G]C	0.00005499	0.00006958	0.00644169	0.00000000	0.00028954	0.00011432	0.00863481	0.00206707	0.00000000	0.01120159	0.01522321
+T[T>G]G	0.00058856	0.00009538	0.00689333	0.00003669	0.00014743	0.00091715	0.00477141	0.00144370	0.00276347	0.00860729	0.01927302
+T[T>G]T	0.00000000	0.00000000	0.01345865	0.00001896	0.00598906	0.00458263	0.12222952	0.00515652	0.00150115	0.02493942	0.08764656
diff --git a/SigProfilerAssignment/DecompositionPlots/ExampleSample/Decomposed_Solution_Signatures_SBS96.txt b/SigProfilerAssignment/DecompositionPlots/ExampleSample/Decomposed_Solution_Signatures_SBS96.txt
new file mode 100644
index 0000000..2c21e95
--- /dev/null
+++ b/SigProfilerAssignment/DecompositionPlots/ExampleSample/Decomposed_Solution_Signatures_SBS96.txt
@@ -0,0 +1,97 @@
+MutationType	SBS1	SBS2	SBS3	SBS5	SBS7a	SBS7b	SBS7c	SBS7d	SBS8	SBS13	SBS18	SBS34	SBS36	SBS39	SBS40	SBS47	SBS50
+A[C>A]A	0.00089628	0.00000058	0.02069825	0.01194370	0.00006693	0.00231475	0.00481985	0.00004036	0.04388801	0.00182303	0.05138118	0.00482212	0.02513173	0.01165545	0.02808571	0.06741745	0.11865803
+A[C>A]C	0.00234181	0.00015054	0.01667106	0.00953978	0.00018154	0.00046500	0.00116518	0.00077588	0.04829968	0.00073328	0.01600527	0.00699725	0.00842469	0.00723199	0.01355033	0.02998528	0.12857688
+A[C>A]G	0.00017436	0.00005102	0.00169583	0.00179309	0.00006926	0.00017994	0.00036635	0.00024319	0.00447737	0.00025751	0.00236090	0.00005014	0.00217542	0.00259017	0.00283200	0.00133627	0.00560273
+A[C>A]T	0.00129516	0.00009800	0.01214328	0.00658059	0.00024778	0.00070552	0.00195636	0.00404655	0.04678547	0.00034866	0.02135583	0.00121820	0.01785586	0.00737362	0.01474361	0.01183574	0.08298112
+A[C>G]A	0.00188157	0.00000000	0.01960363	0.01005261	0.00006483	0.00000850	0.00111765	0.00117871	0.00430919	0.00387645	0.00172601	0.00075451	0.00183502	0.04711988	0.01215055	0.00102419	0.00383894
+A[C>G]C	0.00125308	0.00013528	0.01182130	0.00576025	0.00002191	0.00019064	0.00032321	0.00258626	0.00298084	0.00096719	0.00262365	0.00113605	0.00169101	0.02275802	0.00877738	0.00062293	0.00111366
+A[C>G]G	0.00011329	0.00001483	0.00024517	0.00166709	0.00004941	0.00048855	0.00000000	0.00088130	0.00027717	0.00025751	0.00186540	0.00000000	0.00048559	0.01319337	0.00218219	0.00031761	0.00080303
+A[C>G]T	0.00115350	0.00009139	0.01731910	0.01005506	0.00009552	0.00028320	0.00192641	0.00290752	0.00568394	0.00400764	0.00407158	0.00201053	0.00190529	0.04324526	0.01454437	0.00171071	0.00196482
+A[C>T]A	0.02528997	0.00006121	0.01413054	0.03244704	0.00012186	0.00140077	0.00132720	0.00332635	0.00677726	0.00719196	0.00917877	0.00348539	0.00594385	0.00956344	0.01962016	0.00424591	0.00350988
+A[C>T]C	0.00649134	0.00140371	0.01252856	0.01808921	0.01795130	0.03843096	0.00778138	0.00141991	0.00284948	0.00000000	0.00471041	0.00372985	0.00332127	0.00408633	0.01223575	0.00094903	0.00182235
+A[C>T]G	0.35956302	0.00003190	0.00249045	0.00598990	0.00000000	0.00052532	0.00090082	0.00117702	0.00313028	0.00029556	0.01185306	0.00011378	0.00686618	0.00582060	0.00025895	0.00295336	0.01349705
+A[C>T]T	0.00969348	0.00186383	0.01204374	0.02190211	0.00741350	0.01073191	0.00746610	0.03287195	0.01244294	0.00031861	0.00795355	0.00383288	0.00429937	0.01275436	0.01683561	0.00247655	0.00690180
+A[T>A]A	0.00081666	0.00009695	0.00551300	0.00741241	0.00195551	0.00249627	0.01248687	0.00008961	0.01958337	0.00000000	0.00250693	0.10291810	0.00245560	0.00533806	0.00613072	0.13847370	0.00539337
+A[T>A]C	0.00225944	0.00088099	0.00718610	0.00690842	0.00067031	0.00046468	0.00341822	0.00108053	0.02123121	0.00006541	0.00087736	0.04403314	0.00142839	0.00287358	0.00442901	0.00713088	0.00393490
+A[T>A]G	0.00116316	0.00002577	0.00967552	0.00915544	0.00059140	0.00156314	0.00021237	0.00372780	0.02288596	0.00059608	0.00261636	0.03455508	0.00254489	0.00697316	0.00696140	0.00747181	0.00057628
+A[T>A]T	0.00018662	0.00000000	0.00612921	0.00622074	0.00373577	0.00830222	0.05100195	0.04138646	0.02508072	0.00061191	0.00788507	0.31541959	0.00308640	0.00614592	0.01074268	0.06776133	0.00242248
+A[T>C]A	0.00111271	0.00006238	0.01656914	0.04640289	0.00049392	0.00102257	0.00029002	0.00439497	0.00981177	0.00193064	0.00203373	0.00461633	0.00528356	0.01125918	0.01879418	0.00283971	0.00264638
+A[T>C]C	0.00308013	0.00002157	0.00773428	0.01335826	0.00022711	0.00045373	0.00053272	0.00393191	0.00499382	0.00014246	0.00208848	0.00121984	0.00168809	0.00562743	0.00732184	0.00564694	0.00926800
+A[T>C]G	0.00010815	0.00001334	0.01234532	0.03834845	0.00018840	0.00150302	0.00107695	0.00925905	0.00700632	0.00043241	0.00209309	0.00001947	0.00386260	0.00968606	0.01557022	0.00209612	0.00113646
+A[T>C]T	0.00585346	0.00015654	0.01735438	0.03842810	0.00061927	0.00215317	0.00266578	0.05135546	0.01494811	0.00096835	0.00426437	0.00233570	0.00514736	0.01365761	0.01947738	0.00130310	0.00494547
+A[T>G]A	0.00017558	0.00024061	0.00396655	0.00387695	0.00047678	0.00008461	0.01198336	0.00372968	0.00164701	0.00006206	0.00072590	0.00281776	0.00109697	0.00390050	0.00726641	0.00017159	0.00074763
+A[T>G]C	0.00020973	0.00007485	0.00259138	0.00259190	0.00024711	0.00092737	0.00104945	0.00266130	0.00066584	0.00000000	0.00085738	0.00045818	0.00062230	0.00296338	0.00703255	0.00171301	0.00060621
+A[T>G]G	0.00027345	0.00000207	0.00632321	0.00797086	0.00027807	0.00147296	0.00060793	0.01067964	0.00478798	0.00008335	0.00200252	0.00019674	0.00094151	0.00769660	0.00809652	0.00369077	0.00396254
+A[T>G]T	0.00011421	0.00000380	0.00398248	0.00484615	0.00031115	0.00073408	0.00000000	0.01439967	0.00074239	0.00032312	0.00185058	0.00114789	0.00098926	0.00644719	0.01807180	0.00809928	0.00010353
+C[C>A]A	0.00031909	0.00021067	0.02263624	0.00747649	0.00045949	0.00114499	0.00010997	0.01464344	0.04034624	0.00141776	0.07464142	0.00195207	0.05626099	0.01017222	0.02094358	0.02473028	0.02268214
+C[C>A]C	0.00184352	0.00009720	0.02563163	0.00622173	0.00024407	0.00156771	0.00313928	0.00327465	0.03931194	0.00098715	0.01990849	0.00003700	0.02050967	0.00918875	0.01490524	0.00533505	0.00293382
+C[C>A]G	0.00009447	0.00000000	0.00250279	0.00345075	0.00000000	0.00040615	0.00190985	0.00008518	0.00340049	0.00000435	0.01199659	0.00029567	0.00709512	0.00572974	0.00253484	0.00027002	0.00000000
+C[C>A]T	0.00000000	0.00042651	0.01549708	0.00653222	0.00037576	0.00149690	0.01362319	0.00011819	0.03321085	0.00000000	0.03662370	0.00062081	0.06101491	0.00607462	0.01480513	0.00068578	0.00115960
+C[C>G]A	0.00002465	0.00000000	0.01941686	0.00700355	0.00000000	0.00046001	0.00020783	0.00133306	0.00503070	0.00568116	0.00061831	0.00011913	0.00125024	0.02900593	0.00761219	0.00096106	0.00006613
+C[C>G]C	0.00007910	0.00035800	0.01428482	0.00919073	0.00013322	0.00097097	0.00229604	0.00029085	0.00553204	0.00066082	0.00229557	0.00011895	0.00139100	0.03823576	0.00948054	0.00023993	0.00029338
+C[C>G]G	0.00035680	0.00004889	0.00149569	0.00248334	0.00007757	0.00078741	0.00026198	0.00132123	0.00001047	0.00048980	0.00357898	0.00018851	0.00041871	0.01227801	0.00167658	0.00066757	0.00141879
+C[C>G]T	0.00000000	0.00006443	0.02244058	0.00959200	0.00009657	0.00089412	0.00427869	0.00000000	0.00552508	0.00648279	0.00382380	0.00007370	0.00210779	0.04049747	0.01399941	0.00013776	0.00051627
+C[C>T]A	0.00204545	0.00437545	0.01619748	0.01952138	0.05049345	0.10746881	0.00273405	0.03595217	0.00268640	0.00001954	0.01180141	0.00475504	0.00680576	0.00917514	0.01973530	0.00086858	0.00387109
+C[C>T]C	0.00027807	0.00017339	0.02046478	0.01925292	0.05623727	0.18407894	0.00606521	0.00264413	0.00407304	0.00137671	0.00686640	0.00051815	0.00678240	0.00391486	0.01754154	0.00466690	0.00431444
+C[C>T]G	0.19867546	0.00278066	0.00223356	0.01745321	0.00671608	0.02199983	0.00893930	0.00264245	0.00148584	0.00199736	0.01679523	0.00937606	0.00532634	0.00755647	0.00235520	0.00151449	0.00107908
+C[C>T]T	0.00020050	0.00146898	0.02314499	0.02325028	0.05717273	0.12658337	0.02078797	0.00013940	0.01459265	0.00146876	0.00670930	0.00003535	0.00579894	0.00704172	0.02175448	0.00301663	0.01199930
+C[T>A]A	0.00004376	0.00024488	0.00794778	0.00354418	0.00017785	0.00111923	0.00348314	0.00161772	0.01902024	0.00021058	0.00054394	0.02360545	0.00126400	0.00495022	0.00109199	0.01400315	0.00019358
+C[T>A]C	0.00039864	0.00024511	0.01776120	0.00517973	0.00026142	0.00095432	0.01340827	0.00008143	0.02913883	0.00034350	0.00306126	0.00040608	0.00146001	0.00643296	0.00760980	0.00056933	0.00053492
+C[T>A]G	0.00032969	0.00015015	0.01321284	0.00501588	0.00011253	0.00088239	0.00096463	0.00120575	0.02762921	0.00022771	0.00322147	0.00116532	0.00214678	0.00681403	0.00346629	0.00005821	0.00051755
+C[T>A]T	0.00026286	0.00000000	0.01263027	0.00427725	0.00037036	0.00011120	0.04856837	0.00114805	0.04157402	0.00052356	0.00225343	0.00026521	0.00195351	0.00823355	0.00923682	0.00007553	0.00020827
+C[T>C]A	0.00000000	0.00030433	0.00883865	0.01331570	0.00045315	0.00152895	0.00759866	0.01024894	0.00239255	0.00004776	0.00038738	0.00059163	0.00150476	0.00735519	0.01091988	0.00191043	0.00084153
+C[T>C]C	0.00253589	0.00002863	0.01446839	0.01037941	0.00025942	0.00083677	0.00358221	0.00008904	0.00698534	0.00012254	0.00246101	0.00004011	0.00188002	0.00790135	0.00985679	0.00626158	0.01769723
+C[T>C]G	0.00036632	0.00000000	0.01010983	0.02082442	0.00010450	0.00072949	0.00217820	0.00093948	0.00126133	0.00000000	0.00162579	0.00080776	0.00185586	0.00778603	0.01051908	0.00310068	0.00242727
+C[T>C]T	0.00004307	0.00018623	0.01571324	0.01482116	0.00181687	0.00568906	0.04298351	0.03963261	0.00642508	0.00011212	0.00255256	0.00157342	0.00215285	0.00855214	0.01353672	0.00541599	0.00137521
+C[T>G]A	0.00003612	0.00015418	0.00437428	0.00259306	0.00008460	0.00035875	0.00329242	0.00148710	0.00122130	0.00004171	0.00011140	0.00105577	0.00047952	0.00531097	0.00335611	0.00013703	0.00089669
+C[T>G]C	0.00021504	0.00015570	0.00702465	0.00460087	0.00017228	0.00078896	0.00558345	0.00004988	0.00194592	0.00000283	0.00199082	0.00000000	0.00056600	0.00738192	0.00566241	0.00005135	0.00006179
+C[T>G]G	0.00013025	0.00012193	0.01071041	0.00613720	0.00000000	0.00128911	0.00119450	0.00002592	0.00470497	0.00000000	0.00294047	0.00043426	0.00088981	0.00985028	0.00560016	0.00367080	0.00367099
+C[T>G]T	0.00017288	0.00020325	0.00699140	0.00726137	0.00002645	0.00000365	0.00339081	0.00015574	0.00057090	0.00005556	0.00412796	0.00000065	0.00106646	0.00491822	0.01303905	0.00010633	0.00046936
+G[C>A]A	0.00160430	0.00008668	0.00712164	0.01019009	0.00004071	0.00074389	0.00105171	0.00016844	0.02417369	0.00095413	0.10915499	0.00279277	0.06776895	0.00687942	0.01419531	0.01107862	0.01421212
+G[C>A]C	0.00034901	0.00000000	0.01103898	0.00774909	0.00014029	0.00021738	0.00075357	0.00000000	0.02653632	0.00045976	0.01756608	0.00047161	0.01948745	0.00704628	0.01033876	0.00352171	0.00769221
+G[C>A]G	0.00059137	0.00001387	0.00141715	0.00231944	0.00004228	0.00007212	0.00000000	0.00001811	0.00271561	0.00016360	0.00751152	0.00022384	0.00479710	0.00449418	0.00252922	0.00077538	0.00024230
+G[C>A]T	0.00000000	0.00005175	0.01003948	0.00684830	0.00000000	0.00014733	0.00036545	0.00007458	0.02700850	0.00006215	0.06270841	0.00001349	0.06942435	0.00591969	0.01085178	0.00141450	0.00205221
+G[C>G]A	0.00000974	0.00006576	0.01268511	0.00467545	0.00001965	0.00005096	0.00018230	0.00019652	0.00257720	0.00150812	0.00063590	0.00003320	0.00088690	0.02399797	0.00505833	0.00167676	0.02672278
+G[C>G]C	0.00016884	0.00026611	0.00874003	0.00514580	0.00003375	0.00045700	0.00048037	0.00000000	0.00242068	0.00048830	0.00136061	0.00019449	0.00109617	0.02159507	0.00544305	0.00230733	0.03348853
+G[C>G]G	0.00016723	0.00000000	0.00239825	0.00149673	0.00004486	0.00033342	0.00017888	0.00054216	0.00048366	0.00024041	0.00063490	0.00000000	0.00017083	0.00978204	0.00118030	0.00046047	0.00278047
+G[C>G]T	0.00000000	0.00013544	0.01475804	0.00674788	0.00004233	0.00027763	0.00128866	0.00088886	0.00487960	0.00272852	0.00123806	0.00002687	0.00105646	0.03256334	0.00701346	0.00222708	0.01438557
+G[C>T]A	0.00450829	0.00000000	0.01638078	0.01938115	0.00008512	0.00085258	0.00015726	0.00036596	0.00027570	0.00721884	0.00969376	0.00023157	0.00372379	0.00802932	0.01429528	0.00105796	0.00242207
+G[C>T]C	0.00009554	0.00000013	0.01357085	0.02187979	0.01189410	0.02659102	0.00000966	0.00018401	0.00024814	0.00093889	0.00829566	0.00000000	0.00345090	0.00456234	0.01175780	0.00173050	0.00160339
+G[C>T]G	0.21962122	0.00000000	0.00052326	0.01219192	0.00000549	0.00017413	0.00003409	0.00015618	0.00189300	0.00017756	0.01470510	0.01646777	0.00566117	0.00543667	0.00000000	0.00170326	0.00546163
+G[C>T]T	0.00003919	0.00005094	0.01134461	0.01867718	0.01622484	0.00540228	0.00076313	0.04242744	0.00462859	0.00128342	0.00673386	0.00051646	0.00365232	0.00865341	0.01276089	0.00405289	0.01639754
+G[T>A]A	0.00008310	0.00000000	0.00710777	0.00369558	0.00040524	0.00052868	0.00174659	0.00002395	0.01288771	0.00000679	0.00161501	0.01903360	0.00088790	0.00499900	0.00267018	0.01609612	0.00073845
+G[T>A]C	0.00013173	0.00013248	0.00751401	0.00292382	0.00022587	0.00025674	0.00228671	0.00011294	0.01356253	0.00013145	0.00196395	0.00241893	0.00063526	0.00353985	0.00344850	0.00022886	0.00105691
+G[T>A]G	0.00024910	0.00006398	0.01155481	0.00409481	0.00028997	0.00065236	0.00000000	0.00134987	0.01554055	0.00004713	0.00182761	0.00647227	0.00116800	0.00665125	0.00439652	0.00001304	0.00019863
+G[T>A]T	0.00025881	0.00006239	0.01213731	0.00317805	0.00030310	0.00005507	0.02008766	0.00867711	0.02773070	0.00035559	0.00342310	0.00734442	0.00110761	0.00404030	0.00569848	0.00000323	0.00077718
+G[T>C]A	0.00107462	0.00000000	0.01004753	0.01419826	0.00010207	0.00026735	0.00000000	0.00080849	0.00261782	0.00029085	0.00071464	0.00010919	0.00236100	0.00752874	0.00605577	0.00041951	0.00139216
+G[T>C]C	0.00194027	0.00002771	0.00566564	0.00797770	0.00007472	0.00000000	0.00042611	0.00233944	0.00263214	0.00018403	0.00227617	0.00064572	0.00140945	0.00692886	0.00460470	0.00109413	0.00541542
+G[T>C]G	0.00118476	0.00010730	0.01085754	0.01494456	0.00007249	0.00052606	0.00023174	0.00256975	0.00279929	0.00019552	0.00397479	0.00043611	0.00183685	0.00572386	0.00563273	0.00308559	0.00370304
+G[T>C]T	0.00007152	0.00001242	0.01006509	0.01352151	0.00080331	0.00674815	0.00699605	0.31499094	0.00620733	0.00000000	0.00311641	0.00000000	0.00262068	0.00741874	0.00721939	0.00314543	0.00115687
+G[T>G]A	0.00000000	0.00021183	0.00444991	0.00253756	0.00009156	0.00032464	0.00250378	0.00007559	0.00131898	0.00008888	0.00087816	0.00036565	0.00018666	0.00335618	0.00250896	0.02213216	0.00874637
+G[T>G]C	0.00000000	0.00013451	0.00235064	0.00171812	0.00012201	0.00032192	0.00167222	0.00002249	0.00065904	0.00000000	0.00003726	0.00000000	0.00031511	0.00583271	0.00225208	0.01043940	0.00965314
+G[T>G]G	0.00035239	0.00003720	0.01085754	0.00528041	0.00032496	0.00239662	0.00602335	0.00379963	0.00395487	0.00042714	0.00582237	0.00005600	0.00152738	0.00769830	0.00443640	0.02707359	0.03503416
+G[T>G]T	0.00001465	0.00000000	0.00575289	0.00231938	0.00082708	0.00180279	0.00667939	0.00677528	0.00127305	0.00000287	0.00211718	0.00040944	0.00048359	0.00586782	0.00541208	0.08716497	0.03609027
+T[C>A]A	0.00006656	0.00064008	0.00836784	0.00782217	0.00038952	0.00288066	0.00251440	0.01138612	0.02965314	0.07912197	0.07362075	0.00422750	0.14060085	0.00595650	0.02589146	0.01680259	0.01894309
+T[C>A]C	0.00256283	0.00017054	0.01674057	0.00913939	0.00063615	0.00350171	0.01418943	0.00776204	0.02501333	0.02948905	0.04355859	0.00120965	0.07709561	0.00784072	0.02094334	0.00008075	0.00088466
+T[C>A]G	0.00000000	0.00008414	0.00138152	0.00225400	0.00003383	0.00029345	0.00000000	0.00000000	0.00186178	0.01193373	0.01247580	0.00000000	0.01443467	0.00295241	0.00310859	0.00002340	0.00004114
+T[C>A]T	0.00000592	0.00043888	0.00987812	0.01258549	0.00060965	0.00139468	0.00370599	0.00018996	0.03160872	0.03540465	0.12118968	0.00003155	0.20653522	0.00649671	0.02389804	0.00019009	0.00183667
+T[C>G]A	0.00000000	0.00000000	0.01323333	0.00777241	0.00000000	0.00025231	0.00193569	0.00373545	0.00146276	0.31748943	0.00213480	0.00000061	0.00396873	0.03456364	0.01244782	0.00013720	0.00092921
+T[C>G]C	0.00020563	0.00009901	0.02022819	0.00757463	0.00005091	0.00161158	0.00460657	0.00058815	0.00133537	0.06369234	0.00463559	0.00013881	0.00240674	0.03660999	0.01406196	0.00118490	0.00049225
+T[C>G]G	0.00006913	0.00004064	0.00050950	0.00167580	0.00000625	0.00035605	0.00000860	0.00085863	0.00007663	0.01361037	0.00088313	0.00000000	0.00029655	0.00943595	0.00170629	0.00000000	0.00010112
+T[C>G]T	0.00157124	0.00117701	0.02328344	0.01238729	0.00027947	0.00070624	0.01222082	0.00008484	0.00024673	0.36800888	0.00315888	0.00211961	0.00753655	0.05028749	0.02350139	0.00091479	0.00041797
+T[C>T]A	0.00112274	0.53690800	0.00573112	0.02020229	0.23770465	0.00656592	0.01726153	0.00020675	0.00501516	0.00694070	0.01137231	0.00184149	0.01066971	0.00386475	0.02987477	0.00719827	0.01934189
+T[C>T]C	0.00003778	0.09760935	0.01325295	0.02292323	0.33107944	0.20990379	0.01368981	0.00565149	0.00025113	0.00449357	0.01138917	0.00028655	0.00685072	0.00526705	0.02303768	0.03694086	0.10384223
+T[C>T]G	0.10956424	0.04359916	0.00096902	0.01558197	0.07287854	0.05614706	0.00004559	0.00172119	0.00004086	0.00117365	0.01159169	0.00029248	0.00381979	0.00476702	0.00207893	0.00189938	0.00389770
+T[C>T]T	0.00000000	0.29923905	0.00809471	0.02081065	0.10641588	0.10089193	0.00230506	0.04972820	0.00522188	0.00141619	0.00372509	0.00079658	0.00827134	0.00419558	0.02221228	0.08009402	0.08121055
+T[T>A]A	0.00692145	0.00043045	0.00659585	0.00639450	0.00036206	0.00327727	0.01564683	0.01698477	0.01165265	0.00030188	0.01097084	0.27421883	0.00249791	0.00678560	0.00723012	0.15793801	0.00171576
+T[T>A]C	0.00000000	0.00018977	0.01030857	0.00406534	0.00038336	0.00219550	0.03367062	0.00121218	0.01914612	0.00022927	0.00268719	0.00000000	0.00100360	0.00362667	0.01012074	0.00001207	0.00065322
+T[T>A]G	0.00002827	0.00005009	0.00666354	0.00475779	0.00000000	0.00168542	0.01214950	0.00558244	0.01281178	0.00018793	0.00178222	0.00767790	0.00086786	0.00542810	0.00498945	0.00044853	0.00007503
+T[T>A]T	0.00227982	0.00020571	0.01295758	0.00872320	0.00079841	0.00000000	0.27886920	0.02731471	0.03777954	0.00006220	0.00709521	0.04562227	0.00269709	0.01067670	0.02094912	0.00433253	0.00294634
+T[T>C]A	0.00026264	0.00000000	0.01540045	0.01824103	0.00218661	0.00606901	0.03068404	0.08258464	0.00210761	0.00002254	0.00182847	0.00141142	0.00301577	0.00602489	0.01034322	0.00138702	0.00110661
+T[T>C]C	0.00338335	0.00004299	0.00882610	0.00953489	0.00058735	0.00169563	0.02057649	0.01409284	0.00259209	0.00002461	0.00608309	0.00609582	0.00224334	0.00632947	0.00741860	0.01716799	0.02852903
+T[T>C]G	0.00041997	0.00011697	0.00688202	0.01261460	0.00031799	0.00377733	0.01284660	0.02272851	0.00000000	0.00009976	0.00324584	0.00108696	0.00137345	0.00495091	0.00597342	0.00156788	0.00101499
+T[T>C]T	0.00438739	0.00003592	0.01385464	0.01844333	0.00081242	0.00295538	0.08805870	0.04312323	0.00455548	0.00053276	0.00336773	0.00702186	0.00279698	0.00945935	0.01017528	0.01145383	0.00510365
+T[T>G]A	0.00000000	0.00001703	0.00734561	0.00528990	0.00013018	0.00096598	0.01960934	0.00021460	0.00000000	0.00018766	0.00070701	0.00000000	0.00080014	0.00850990	0.00857879	0.00243994	0.00033198
+T[T>G]C	0.00005499	0.00006958	0.00616551	0.00644169	0.00011432	0.00151921	0.01713066	0.00011333	0.00111931	0.00000000	0.00206707	0.00000000	0.00073204	0.00499282	0.01120159	0.00002207	0.00064436
+T[T>G]G	0.00058856	0.00009538	0.00799426	0.00689333	0.00000000	0.00133842	0.00760837	0.00012461	0.00306887	0.00003669	0.00144370	0.00150198	0.00089772	0.00723747	0.00860729	0.00152818	0.00867719
+T[T>G]T	0.00000000	0.00000000	0.01046574	0.01345865	0.00008294	0.00176129	0.02168983	0.00016609	0.00099283	0.00001896	0.00515652	0.00023009	0.00180805	0.01087626	0.02493942	0.00360547	0.00159801
diff --git a/SigProfilerAssignment/DecompositionPlots/PlotDecomposition.py b/SigProfilerAssignment/DecompositionPlots/PlotDecomposition.py
index 60a7c97..0cccfa3 100644
--- a/SigProfilerAssignment/DecompositionPlots/PlotDecomposition.py
+++ b/SigProfilerAssignment/DecompositionPlots/PlotDecomposition.py
@@ -21,8 +21,11 @@
 import pandas as pd
 import numpy as np
 import scipy.stats
-import sigProfilerPlotting as pltCNV
-from SigProfilerAssignment.DecompositionPlots import SigProfilerPlottingMatrix as sigPlt
+import sigProfilerPlotting as sigPlt
+import shutil
+import SigProfilerAssignment
+import SigProfilerAssignment.DecompositionPlots
+from SigProfilerAssignment.DecompositionPlots import SigProfilerPlottingMatrix as mPlt
 from SigProfilerAssignment.DecompositionPlots import PlotDecomposition_SBS96 as spd_96
 from SigProfilerAssignment.DecompositionPlots import PlotDecomposition_SBS288 as spd_288
 from SigProfilerAssignment.DecompositionPlots import PlotDecomposition_SBS1536 as spd_1536
@@ -34,12 +37,108 @@
 import io
 from PIL import Image
 from reportlab.lib.utils import ImageReader
+import json
+import base64
 # Global Variables
 SBS_CONTEXTS = ["6", "24", "96", "288", "384", "1536", "6144"]
 DBS_CONTEXTS = ["78", "186", "1248", "2976"]
 ID_CONTEXTS = ["28", "83", "415"]
 CNV_CONTEXTS = ["48"]
-mtype_options = ["6", "24", "96", "384", "1536", "6144", "28", "83", "415", "78", "186", "1248", "2976"]
+MTYPE_OPTIONS = ["6", "24", "96", "384", "1536", "6144", "28", "83", "415", "78", "186", "1248", "2976"]
+DECOMPOSITION_PATH = SigProfilerAssignment.DecompositionPlots.__path__[0]
+REFSIG_PATH = os.path.join(SigProfilerAssignment.__path__[0], "data/Reference_Signatures")
+TEMPLATE_PATH = os.path.join(DECOMPOSITION_PATH,'CosmicTemplates')
+
+# Remove templates so that they can be rebuilt
+def remove_cosmic_templates():
+	if not os.path.exists(TEMPLATE_PATH):
+		print("No files are installed at: ", TEMPLATE_PATH)
+	try:
+		shutil.rmtree(TEMPLATE_PATH)
+	except OSError as e:
+		print("Error: %s : %s" % (TEMPLATE_PATH, e.strerror))
+
+# Create a set of serialized JSON reference signature plots for fast loading
+def install_cosmic_plots(context_type="96", genome_build="GRCh37", cosmic_version="3.3", exome=False):
+
+	if not os.path.exists(TEMPLATE_PATH):
+		os.mkdir(TEMPLATE_PATH)
+
+	# determine if context is from SBS, ID, DBS, or CNV
+	context_type_str = ""
+	if context_type in SBS_CONTEXTS:
+		context_type_str="SBS"
+	elif context_type in DBS_CONTEXTS:
+		context_type_str="DBS"
+	elif context_type in ID_CONTEXTS:
+		context_type_str="ID"
+	elif context_type in CNV_CONTEXTS:
+		context_type_str="CNV"
+	else:
+		raise ValueError("ERROR: context", context_type, "not in context lists.")
+
+	# if exome is true, append _exome to end of file name
+	exome_str = ""
+	if exome:
+		exome_str = "_exome"
+
+	cosmic_file_name = "COSMIC_v" + str(cosmic_version) + "_" + \
+						context_type_str + "_" + genome_build + \
+						exome_str + ".txt"
+	json_file_name = "COSMIC_v" + str(cosmic_version) + "_" + \
+						context_type_str + "_" + genome_build + \
+						exome_str + ".json"
+
+	# Load cosmic plots if they exist
+	filename= os.path.join(TEMPLATE_PATH, json_file_name)
+	if os.path.exists(filename):
+		cosmic_buff_bytes = json.load(open(filename))
+		cosmic_buff_plots = {}
+		# Read from JSON, decode, and convert to bytesIO
+		for tmp_plots in cosmic_buff_bytes.keys():
+			cosmic_buff_plots[tmp_plots] = io.BytesIO(base64.b64decode(cosmic_buff_bytes[tmp_plots]))
+		return cosmic_buff_plots
+
+	# Generate cosmic plots if they were not found
+	else:
+		cosmic_file_path = os.path.join(REFSIG_PATH, genome_build, cosmic_file_name)
+		json_file_path = os.path.join(TEMPLATE_PATH, json_file_name)
+		print("Generating plots for",  "COSMIC_v" + str(cosmic_version) + "_" + \
+						context_type_str + "_" + genome_build + \
+						exome_str,"now...")
+
+		# Create the respective plots
+		if context_type_str == "SBS":
+			cosmic_buff_plots = sigPlt.plotSBS(cosmic_file_path, "buffer",
+							"buffer", context_type, percentage=True,
+							savefig_format="buffer_stream")
+		elif context_type_str == "DBS":
+			cosmic_mtx = pd.read_csv(cosmic_file_path, sep="\t")
+			cosmic_buff_plots = mPlt.plotDBS(cosmic_mtx, "buffer",
+						"buffer", context_type, percentage=True)
+		elif context_type_str == "ID":
+			cosmic_buff_plots = sigPlt.plotID(cosmic_file_path, "buffer",
+						"buffer", context_type, percentage=True,
+						savefig_format="buffer_stream")
+
+		# Process the plots to be stored in JSON file
+		cosmic_img_dict = {}
+		for tmp_plot in cosmic_buff_plots.keys():
+			# start at beggining of binary file
+			seek_start = cosmic_buff_plots[tmp_plot].seek(0)
+			encoded = base64.b64encode(cosmic_buff_plots[tmp_plot].getvalue())
+			cosmic_img_dict[tmp_plot] = encoded.decode('ascii')
+
+		# JSON output processing
+		json_object = json.dumps(cosmic_img_dict)
+		with open(json_file_path, "w") as outfile:
+			outfile.write(json_object)
+
+		print("Plots for", "COSMIC_v" + str(cosmic_version) + "_" + \
+						context_type_str + "_" + genome_build + \
+						exome_str, "have been successfully installed.")
+		return cosmic_buff_plots
+
 
 # Helper function for converting BytesIO to image so it can be plotted by reportlab
 def bytes_to_img(byte_png):
@@ -50,13 +149,12 @@ def bytes_to_img(byte_png):
 	
 # Helper function to convert byte array to image array
 def open_byte_to_img_dict(byte_dict):
+
 	img_dict = dict()
 	for name in byte_dict.keys():
 		tmp_img = bytes_to_img(byte_dict[name])
 		img_dict[name] = tmp_img
 	return img_dict
-		
-	
 
 def calculate_similarities(denovo, denovo_name, est_denovo):
 	from numpy import inf
@@ -121,68 +219,90 @@ def calculate_similarities(denovo, denovo_name, est_denovo):
 	return similarities_dataframe
 
 
-def genSBS_pngs(denovo_mtx, basis_mtx, output_path, project, mtype):
+def genSBS_pngs(denovo_mtx, basis_mtx, output_path, project, mtype, ss_decomp=False):
 	denovo_plots = dict()
 	basis_plots = dict()
 	if mtype == "1536" or mtype == "288":
-		denovo_plots = sigPlt.plotSBS(denovo_mtx, output_path, project, mtype, True)
-		basis_plots = sigPlt.plotSBS(basis_mtx, output_path, project, "96", True)
+		denovo_plots = mPlt.plotSBS(denovo_mtx, output_path, project, mtype,
+					percentage=True)
+		if basis_mtx is not None:
+			basis_plots = sigPlt.plotSBS(basis_mtx, output_path, project, "96",
+					percentage=True, savefig_format="buffer_stream")
 	elif mtype == "96":
-		denovo_plots = sigPlt.plotSBS(denovo_mtx, output_path, project, mtype, True)
-		basis_plots = sigPlt.plotSBS(basis_mtx, output_path, project, mtype, True)
+		denovo_plots = sigPlt.plotSBS(denovo_mtx, output_path, project, mtype,
+			percentage=(not ss_decomp), savefig_format="buffer_stream")
+		if basis_mtx is not None:
+			basis_plots = sigPlt.plotSBS(basis_mtx, output_path, project, mtype,
+					percentage=True, savefig_format="buffer_stream")
 	return denovo_plots,basis_plots
 
 def genDBS_pngs(denovo_mtx, basis_mtx, output_path, project, mtype):
 	denovo_plots = dict()
 	basis_plots = dict()
-	denovo_plots = sigPlt.plotDBS(denovo_mtx, output_path, project, mtype, True)
-	basis_plots = sigPlt.plotDBS(basis_mtx, output_path, project, mtype, True)
+	denovo_plots = mPlt.plotDBS(denovo_mtx, output_path, project, mtype,
+			percentage=True)
+	if basis_mtx is not None:
+		basis_plots = mPlt.plotDBS(basis_mtx, output_path, project, mtype,
+				percentage=True)
 	return denovo_plots,basis_plots
 
 def genID_pngs(denovo_mtx, basis_mtx, output_path, project, mtype):
 	denovo_plots = dict()
 	basis_plots = dict()
-	denovo_plots = sigPlt.plotID(denovo_mtx, output_path, project, mtype, True)
-	basis_plots = sigPlt.plotID(basis_mtx, output_path, project, mtype, True)
+	denovo_plots = sigPlt.plotID(denovo_mtx, output_path, project, mtype,
+			percentage=True, savefig_format="buffer_stream")
+	if basis_mtx is not None:
+		basis_plots = sigPlt.plotID(basis_mtx, output_path, project, mtype,
+				percentage=True, savefig_format="buffer_stream")
 	return denovo_plots,basis_plots
 	
 def genCNV_pngs(denovo_mtx, basis_mtx, output_path, project, mtype):
 	denovo_plots = dict()
 	basis_plots = dict()
-	denovo_plots = pltCNV.plotCNV(denovo_mtx, output_path, project, plot_type="pdf", percentage=True, aggregate=False, read_from_file=False, write_to_file=False)
-	basis_plots = pltCNV.plotCNV(basis_mtx, output_path, project, plot_type="pdf", percentage=True, aggregate=False, read_from_file=False, write_to_file=False)
+	denovo_plots = sigPlt.plotCNV(denovo_mtx, output_path, project,
+				plot_type="pdf", percentage=True, aggregate=False,
+				read_from_file=False, write_to_file=False)
+
+	if basis_mtx is not None:
+		basis_plots = sigPlt.plotCNV(basis_mtx, output_path, project,
+				plot_type="pdf", percentage=True, aggregate=False,
+				read_from_file=False, write_to_file=False)
 	return denovo_plots,basis_plots
 
 # signames, weights
-def gen_sub_plots(denovo_mtx, basis_mtx, output_path, project, mtype):
+def gen_sub_plots(denovo_mtx, basis_mtx, output_path, project, mtype, ss_decomp):
+
+	# Make output directory
+	if not os.path.exists(output_path):
+		os.makedirs(output_path)
 
 	if mtype in SBS_CONTEXTS:
-		if not os.path.exists(output_path):
-			os.makedirs(output_path)
-		denovo_plots,basis_plots=genSBS_pngs(denovo_mtx, basis_mtx, output_path, project, mtype)
+		denovo_plots,basis_plots = genSBS_pngs(denovo_mtx, basis_mtx,
+									output_path, project, mtype, ss_decomp)
 		return denovo_plots,basis_plots
+
 	elif mtype in DBS_CONTEXTS:
-		if not os.path.exists(output_path):
-			os.makedirs(output_path)
-		denovo_plots,basis_plots=genDBS_pngs(denovo_mtx, basis_mtx, output_path, project, mtype)
+		denovo_plots,basis_plots = genDBS_pngs(denovo_mtx, basis_mtx,
+									output_path, project, mtype)
 		return denovo_plots,basis_plots
+
 	elif mtype in ID_CONTEXTS:
-		if not os.path.exists(output_path):
-			os.makedirs(output_path)
-		denovo_plots,basis_plots=genID_pngs(denovo_mtx, basis_mtx, output_path, project, mtype)
+		denovo_plots,basis_plots=genID_pngs(denovo_mtx, basis_mtx,
+									output_path, project, mtype)
 		return denovo_plots,basis_plots
+
 	elif mtype in CNV_CONTEXTS:
-		if not os.path.exists(output_path):
-			os.makedirs(output_path)
-		denovo_plots, basis_plots=genCNV_pngs(denovo_mtx, basis_mtx, output_path, project, mtype)
+		denovo_plots, basis_plots=genCNV_pngs(denovo_mtx, basis_mtx,
+									output_path, project, mtype)
 		return denovo_plots,basis_plots
+
 	else:
 		print("ERROR: mtype is " + mtype + " and is not yet supported.")
 
+
 # generate the plot for the reconstruction
-def gen_reconstructed_png(denovo_name, basis_mtx, basis_names, weights, output_path, project, mtype):
+def gen_reconstructed_png_percent(denovo_name, basis_mtx, basis_names, weights, output_path, project, mtype):
 	reconstruction_plot=dict()
-	col_names=[denovo_name]
 	mut_col = basis_mtx.iloc[:,0]
 
 	recon_plot = basis_mtx[basis_names[0]]*float(weights[0].strip("%"))/100
@@ -194,25 +314,65 @@ def gen_reconstructed_png(denovo_name, basis_mtx, basis_names, weights, output_p
 	reconstruction_mtx = pd.concat([mut_col, recon_plot], axis=1)
 	if mtype in SBS_CONTEXTS:
 		if mtype == "1536" or mtype == "288":
-			reconstruction_plot=sigPlt.plotSBS(reconstruction_mtx, output_path, "reconstruction_" + project, "96", True)
+			reconstruction_plot=sigPlt.plotSBS(reconstruction_mtx, output_path, \
+				"reconstruction_" + project, "96", percentage=True, savefig_format='buffer_stream')
 		else:
-			reconstruction_plot=sigPlt.plotSBS(reconstruction_mtx, output_path, "reconstruction_" + project, mtype, True)
+			reconstruction_plot=sigPlt.plotSBS(reconstruction_mtx, output_path, \
+				"reconstruction_" + project, mtype, percentage=True, savefig_format='buffer_stream')
 	elif mtype in DBS_CONTEXTS:
-		reconstruction_plot=sigPlt.plotDBS(reconstruction_mtx, output_path, "reconstruction_" + project, mtype, True)
+		reconstruction_plot=mPlt.plotDBS(reconstruction_mtx, output_path,
+				"reconstruction_" + project, mtype, percentage=True)
 	elif mtype in ID_CONTEXTS:
-		reconstruction_plot=sigPlt.plotID(reconstruction_mtx, output_path, "reconstruction_" + project, mtype, True)
+		reconstruction_plot=sigPlt.plotID(reconstruction_mtx, output_path,
+				"reconstruction_" + project, mtype, percentage=True, savefig_format='buffer_stream')
 	elif mtype in CNV_CONTEXTS:
-		reconstruction_plot = pltCNV.plotCNV(reconstruction_mtx, output_path, "reconstruction_"+project, plot_type="pdf", \
-			percentage=True, aggregate=False, read_from_file=False, write_to_file=False)
+		reconstruction_plot = sigPlt.plotCNV(reconstruction_mtx, output_path, "reconstruction_"+project, plot_type="pdf", \
+										percentage=True, aggregate=False, read_from_file=False, write_to_file=False)
 	else:
 		print("ERROR: mtype is " + mtype + " and is not yet supported.")
 
-	return reconstruction_mtx,reconstruction_plot
+	return reconstruction_mtx, reconstruction_plot
+
+# generate the plot for the reconstruction
+def gen_reconstructed_png_numerical(denovo_mtx, denovo_name, basis_mtx, basis_names, weights, output_path, project, mtype):
+	sample_tmb = denovo_mtx[denovo_name].sum()
+	reconstruction_plot=dict()
+	mut_col = basis_mtx.iloc[:,0]
+
+	recon_plot = basis_mtx[basis_names[0]]*float(weights[0].strip("%"))/100*sample_tmb
+	for i in range(1,len(weights)):
+		recon_plot = recon_plot + basis_mtx[basis_names[i]]*(float(weights[i].strip("%"))/100)*sample_tmb
+
+	recon_plot = pd.Series(recon_plot, name=denovo_name)
+	reconstruction_mtx = pd.concat([mut_col, recon_plot], axis=1)
+	reconstruction_mtx = reconstruction_mtx.round(0)
+	if mtype in SBS_CONTEXTS:
+		if mtype == "1536" or mtype == "288":
+			reconstruction_plot=sigPlt.plotSBS(reconstruction_mtx, output_path,
+						"reconstruction_" + project, "96", percentage=False)
+		else:
+			reconstruction_plot=sigPlt.plotSBS(reconstruction_mtx, output_path,
+						"reconstruction_" + project, mtype, percentage=False,
+						savefig_format="buffer_stream")
+	elif mtype in DBS_CONTEXTS:
+		reconstruction_plot=mPlt.plotDBS(reconstruction_mtx, output_path,
+				"reconstruction_" + project, mtype, percentage=False)
+	elif mtype in ID_CONTEXTS:
+		reconstruction_plot=sigPlt.plotID(reconstruction_mtx, output_path,
+				"reconstruction_" + project, mtype, percentage=False)
+	elif mtype in CNV_CONTEXTS:
+		reconstruction_plot = sigPlt.plotCNV(reconstruction_mtx, output_path,
+				"reconstruction_"+project, plot_type="pdf", percentage=True,
+				aggregate=False, read_from_file=False, write_to_file=False)
+	else:
+		print("ERROR: mtype is " + mtype + " and is not yet supported.")
+
+	return reconstruction_mtx, reconstruction_plot
 
 
 def gen_decomposition(denovo_name, basis_names, weights, output_path, project, \
 	mtype, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict, \
-	reconstruction=False, statistics=None, sig_version=None, custom_text=None):
+	reconstruction=False, statistics=None, cosmic_version=None, custom_text=None):
 
 	"""
 	Generate the correct plot based on mtype.
@@ -237,37 +397,37 @@ def gen_decomposition(denovo_name, basis_names, weights, output_path, project, \
 	elif mtype == "24":
 		print("Need to add support for SBS24 Decomposition")
 	elif mtype == "96":
-		byte_plot=spd_96.gen_decomposition(denovo_name, basis_names, weights, output_path, \
-			project, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict, \
-			reconstruction, statistics, sig_version, custom_text)
+		byte_plot=spd_96.gen_decomposition(denovo_name, basis_names, weights, output_path,
+			project, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict,
+			reconstruction, statistics, cosmic_version, custom_text)
 		return byte_plot
 	elif mtype == "288":
-		byte_plot=spd_288.gen_decomposition(denovo_name, basis_names, weights, output_path, \
-			project, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict, \
-			reconstruction, statistics, sig_version, custom_text)
+		byte_plot=spd_288.gen_decomposition(denovo_name, basis_names, weights, output_path,
+			project, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict,
+			reconstruction, statistics, cosmic_version, custom_text)
 		return byte_plot
 	elif mtype == "384":
 		print("Need to add support for SBS24 Decomposition")
 	elif mtype == "1536":
-		byte_plot=spd_1536.gen_decomposition(denovo_name, basis_names, weights, output_path, \
-			project, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict, \
-			reconstruction, statistics, sig_version, custom_text)
+		byte_plot=spd_1536.gen_decomposition(denovo_name, basis_names, weights, output_path,
+			project, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict,
+			reconstruction, statistics, cosmic_version, custom_text)
 		return byte_plot
 	elif mtype == "6144":
 		print("Need to add support for SBS6144 Decomposition")
 	elif mtype == "28":
 		print("Need to add support for ID28 Decomposition")
 	elif mtype == "83":
-		byte_plot=spd_83.gen_decomposition(denovo_name, basis_names, weights, output_path, \
-			project, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict, \
-			reconstruction, statistics, sig_version, custom_text)
+		byte_plot=spd_83.gen_decomposition(denovo_name, basis_names, weights, output_path,
+			project, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict,
+			reconstruction, statistics, cosmic_version, custom_text)
 		return byte_plot
 	elif mtype == "415":
 		print("Need to add support for ID415 Decomposition")
 	elif mtype == "78":
-		byte_plot=spd_78.gen_decomposition(denovo_name, basis_names, weights, output_path, \
-			project, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict, \
-			reconstruction, statistics, sig_version, custom_text)
+		byte_plot=spd_78.gen_decomposition(denovo_name, basis_names, weights, output_path,
+			project, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict,
+			reconstruction, statistics, cosmic_version, custom_text)
 		return byte_plot
 	elif mtype == "186":
 		print("Need to add support for DBS186 Decomposition")
@@ -276,15 +436,15 @@ def gen_decomposition(denovo_name, basis_names, weights, output_path, project, \
 	elif mtype == "2976":
 		print("Need to add support for DBS2976 Decomposition")
 	elif mtype == "48":
-		byte_plot=cnv_48.gen_decomposition(denovo_name, basis_names, weights, output_path, \
-			project, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict, \
-			reconstruction, statistics, sig_version, custom_text)
+		byte_plot=cnv_48.gen_decomposition(denovo_name, basis_names, weights, output_path,
+			project, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict,
+			reconstruction, statistics, cosmic_version, custom_text)
 		return byte_plot
 
 
 
-def run_PlotDecomposition(denovo_mtx, denovo_name, basis_mtx, basis_names, \
-		weights, nonzero_exposures, output_path, project, mtype, sig_version=None, custom_text=None):
+def run_PlotDecomposition(denovo_mtx, denovo_name, basis_mtx, basis_names,
+		weights, nonzero_exposures, output_path, project, mtype, cosmic_version=None, custom_text=None):
 	"""
 	Generates a decomposition plot of the denovo_mtx using the basis_mtx.
 
@@ -311,7 +471,7 @@ def run_PlotDecomposition(denovo_mtx, denovo_name, basis_mtx, basis_names, \
 
 	mtype: String. The context of the data. Valid values include: "96", "1536","78", and "83".
 
-	sig_version: String. The version of signatures being used.
+	cosmic_version: String. The version of signatures being used.
 
 	custom_text: String. A custom message displayed on decomposition plot.
 
@@ -319,20 +479,114 @@ def run_PlotDecomposition(denovo_mtx, denovo_name, basis_mtx, basis_names, \
 	-------
 	None.
 	"""
-	
-	denovo_plots_dict,basis_plots_dict=gen_sub_plots(denovo_mtx, basis_mtx, output_path, project, mtype)
-	reconstructed_mtx,reconstruction_plot_dict = gen_reconstructed_png(denovo_name, basis_mtx, basis_names, \
-		weights, output_path, project, mtype)
+
+	# Create the denovo plots and load basis plots
+	if mtype == "48":
+		denovo_plots_dict, basis_plots_dict = gen_sub_plots(denovo_mtx, basis_mtx,
+				output_path, project, mtype, ss_decomp=False)
+	else:
+		denovo_plots_dict = gen_sub_plots(denovo_mtx, None,
+				output_path, project, mtype, ss_decomp=False)
+		denovo_plots_dict = denovo_plots_dict[0]
+	# Create the matrix and plot for the reconstructed matrix
+	reconstructed_mtx,reconstruction_plot_dict = gen_reconstructed_png_percent(
+		denovo_name, basis_mtx, basis_names, weights, output_path, project, mtype)
+	# Create a subset matrix with the present signatures
 	present_sigs=np.array(basis_mtx[basis_names])
 	reconstructed_mtx = np.dot(present_sigs,nonzero_exposures)
+	# Convert dictionary of bytes to dictionary of images
 	denovo_plots_dict = open_byte_to_img_dict(denovo_plots_dict)
+	# Load in the COSMIC plots
+	if mtype != "48":
+		basis_plots_dict = install_cosmic_plots(context_type=mtype,
+				genome_build="GRCh37", cosmic_version="3.3",
+				exome=False)
+		basis_plots_dict = {key: basis_plots_dict[key] for key in basis_names}
 	basis_plots_dict = open_byte_to_img_dict(basis_plots_dict)
+	# Generate the reconstruction plot
 	reconstruction_plot_dict = open_byte_to_img_dict(reconstruction_plot_dict)
+	# Get the reconstruction statistics
 	statistics=calculate_similarities(denovo_mtx, denovo_name, reconstructed_mtx)
-	byte_plot = gen_decomposition(denovo_name, basis_names, weights, output_path, project, \
-		mtype, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict, \
-		reconstruction=True, statistics=statistics, sig_version=sig_version, \
+	# Return the decomposition plot as a byte array
+	byte_plot = gen_decomposition(denovo_name, basis_names, weights, output_path, project,
+		mtype, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict,
+		reconstruction=True, statistics=statistics, cosmic_version=cosmic_version,
 		custom_text=custom_text)
 	
-
 	return byte_plot
+
+# context="96", genome_build="GRCh37", cosmic_version="3.3", exome=False
+def run_PlotSSDecomposition(denovo_mtx, denovo_name, basis_mtx, basis_names, \
+		weights, output_path, project, context_type, genome_build="GRCh37", \
+		cosmic_version="3.3", custom_text=None, exome=False):
+	"""
+	Generates a reconstruction of a sample given a set of signatures.
+
+	Parameters:
+	----------
+
+	samples: Pandas Dataframe. Samples and their channel counts.
+			df_allgenomes =  pd.DataFrame(allgenomes, columns=allcolnames)
+
+	denovo_mtx: Pandas Dataframe. This format represents the catalog of mutations seperated by tab.
+
+	denovo_name: String. The name of the one sample in denovo_mtx to decompose.
+
+	basis_mtx: Pandas Dataframe. This format represents the catalog of mutations seperated by tab.
+
+	basis_names: List of Strings. The names of the samples in denovo_mtx that
+	the denovo_name sample from denovo_mtx is decomposed into.
+	ie. basis_names=["SBS1", "SBS5", "SBS15", "SBS20"]
+
+	weights: List of Strings. The percentile weight corresponding to each basis
+	in basis_names. Refer to example function call below for more detail.
+	ie. weights=["11.58%", "42.38%", "16.46%", "29.58%"]
+
+	output_path: String. Path to where to store the output.
+
+	project: String. This string is appended to the file name output.
+
+	context_type: String. The context of the data. Valid values include: "96", "1536","78", and "83".
+
+	genome_build: String. The genome being used.
+
+	cosmic_version: String. The version of signatures being used.
+
+	custom_text: String. A custom message displayed on decomposition plot.
+
+	exome: Boolean. True if using exome COSMIC signatures, and False if not.
+
+	Returns:
+	-------
+	None.
+	"""
+
+	# Create the denovo plots
+	denovo_plots_dict=gen_sub_plots(denovo_mtx, None, output_path,
+			project, context_type, ss_decomp=True)
+	denovo_plots_dict = denovo_plots_dict[0]
+	# Load in the COSMIC plots
+	basis_plots_dict = install_cosmic_plots(context_type=context_type,
+			genome_build=genome_build, cosmic_version=cosmic_version,
+			exome=False)
+
+	# Create reconstructed matrix and plot
+	reconstructed_mtx,reconstruction_plot_dict = gen_reconstructed_png_numerical(
+		denovo_mtx, denovo_name, basis_mtx,
+		basis_names, weights, output_path, project, context_type)
+
+	denovo_plots_dict = open_byte_to_img_dict(denovo_plots_dict)
+	# subset basis_plots_dict to only the plots used
+	basis_plots_dict = {key: basis_plots_dict[key] for key in basis_names}
+	basis_plots_dict = open_byte_to_img_dict(basis_plots_dict)
+
+	reconstruction_plot_dict = open_byte_to_img_dict(reconstruction_plot_dict)
+
+	statistics=calculate_similarities(denovo_mtx, denovo_name, reconstructed_mtx[denovo_name])
+	byte_plot = gen_decomposition(denovo_name, basis_names, weights, output_path, project,
+			context_type, denovo_plots_dict, basis_plots_dict, reconstruction_plot_dict,
+			reconstruction=True, statistics=statistics, cosmic_version=cosmic_version,
+			custom_text=custom_text)
+
+
+	return byte_plot
\ No newline at end of file
diff --git a/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_CNV48.py b/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_CNV48.py
index a60d811..6a27110 100644
--- a/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_CNV48.py
+++ b/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_CNV48.py
@@ -43,8 +43,8 @@
 TEXT_X_COORD = GRAPH_X_COORD + WIDTH_GRAPH - 50
 TEXT_Y_COORD = (HEIGHT_LETTER - HEIGHT_GAP) + 55.75
 
-FONTS_DIR = os.path.join(PATHS, "DecompositionPlots/reference_files/Fonts/")
-BRACKET_PATH=os.path.join(PATHS, "DecompositionPlots/reference_files/Accolade_fermante.png")
+FONTS_DIR = os.path.join(PATHS, "DecompositionPlots/ReferenceFiles/Fonts/")
+BRACKET_PATH=os.path.join(PATHS, "DecompositionPlots/ReferenceFiles/Accolade_fermante.png")
 reportlab.rl_config.TTFSearchPath.append(FONTS_DIR)
 pdfmetrics.registerFont(TTFont('Arial-Bold', 'Arial Bold.ttf'))
 
diff --git a/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_DBS78.py b/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_DBS78.py
index 66ee3c9..3a40a30 100644
--- a/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_DBS78.py
+++ b/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_DBS78.py
@@ -41,8 +41,8 @@
 TEXT_X_COORD = GRAPH_X_COORD + WIDTH_GRAPH - 50
 TEXT_Y_COORD = (HEIGHT_LETTER - HEIGHT_GAP) + 63.75
 
-FONTS_DIR = os.path.join(PATHS, "DecompositionPlots/reference_files/Fonts/")
-BRACKET_PATH=os.path.join(PATHS, "DecompositionPlots/reference_files/Accolade_fermante.png")
+FONTS_DIR = os.path.join(PATHS, "DecompositionPlots/ReferenceFiles/Fonts/")
+BRACKET_PATH=os.path.join(PATHS, "DecompositionPlots/ReferenceFiles/Accolade_fermante.png")
 reportlab.rl_config.TTFSearchPath.append(FONTS_DIR)
 pdfmetrics.registerFont(TTFont('Arial-Bold', 'Arial Bold.ttf'))
 
diff --git a/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_ID83.py b/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_ID83.py
index f73701f..050efcb 100644
--- a/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_ID83.py
+++ b/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_ID83.py
@@ -41,8 +41,8 @@
 TEXT_X_COORD = GRAPH_X_COORD + WIDTH_GRAPH - 50
 TEXT_Y_COORD = (HEIGHT_LETTER - HEIGHT_GAP) + 40.75
 
-FONTS_DIR = os.path.join(PATHS, "DecompositionPlots/reference_files/Fonts/")
-BRACKET_PATH=os.path.join(PATHS, "DecompositionPlots/reference_files/Accolade_fermante.png")
+FONTS_DIR = os.path.join(PATHS, "DecompositionPlots/ReferenceFiles/Fonts/")
+BRACKET_PATH=os.path.join(PATHS, "DecompositionPlots/ReferenceFiles/Accolade_fermante.png")
 reportlab.rl_config.TTFSearchPath.append(FONTS_DIR)
 pdfmetrics.registerFont(TTFont('Arial-Bold', 'Arial Bold.ttf'))
 
diff --git a/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_SBS1536.py b/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_SBS1536.py
index df651a8..7278f91 100644
--- a/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_SBS1536.py
+++ b/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_SBS1536.py
@@ -41,8 +41,8 @@
 TEXT_X_COORD = GRAPH_X_COORD + WIDTH_GRAPH - 50
 TEXT_Y_COORD = (HEIGHT_LETTER - HEIGHT_GAP) + 63.75
 
-FONTS_DIR = os.path.join(PATHS, "DecompositionPlots/reference_files/Fonts/")
-BRACKET_PATH=os.path.join(PATHS, "DecompositionPlots/reference_files/Accolade_fermante.png")
+FONTS_DIR = os.path.join(PATHS, "DecompositionPlots/ReferenceFiles/Fonts/")
+BRACKET_PATH=os.path.join(PATHS, "DecompositionPlots/ReferenceFiles/Accolade_fermante.png")
 reportlab.rl_config.TTFSearchPath.append(FONTS_DIR)
 pdfmetrics.registerFont(TTFont('Arial-Bold', 'Arial Bold.ttf'))
 
diff --git a/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_SBS288.py b/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_SBS288.py
index d1b49a8..4753926 100644
--- a/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_SBS288.py
+++ b/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_SBS288.py
@@ -41,8 +41,8 @@
 TEXT_X_COORD = GRAPH_X_COORD + WIDTH_GRAPH - 50
 TEXT_Y_COORD = (HEIGHT_LETTER - HEIGHT_GAP) + 63.75
 
-FONTS_DIR = os.path.join(PATHS, "DecompositionPlots/reference_files/Fonts/")
-BRACKET_PATH=os.path.join(PATHS, "DecompositionPlots/reference_files/Accolade_fermante.png")
+FONTS_DIR = os.path.join(PATHS, "DecompositionPlots/ReferenceFiles/Fonts/")
+BRACKET_PATH=os.path.join(PATHS, "DecompositionPlots/ReferenceFiles/Accolade_fermante.png")
 reportlab.rl_config.TTFSearchPath.append(FONTS_DIR)
 pdfmetrics.registerFont(TTFont('Arial-Bold', 'Arial Bold.ttf'))
 #print(pdfmetrics.sorted_list())
diff --git a/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_SBS96.py b/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_SBS96.py
index 4369ec5..3cf117d 100644
--- a/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_SBS96.py
+++ b/SigProfilerAssignment/DecompositionPlots/PlotDecomposition_SBS96.py
@@ -41,8 +41,8 @@
 TEXT_X_COORD = GRAPH_X_COORD + WIDTH_GRAPH - 50
 TEXT_Y_COORD = (HEIGHT_LETTER - HEIGHT_GAP) + 63.75
 
-FONTS_DIR = os.path.join(PATHS, "DecompositionPlots/reference_files/Fonts/")
-BRACKET_PATH=os.path.join(PATHS, "DecompositionPlots/reference_files/Accolade_fermante.png")
+FONTS_DIR = os.path.join(PATHS, "DecompositionPlots/ReferenceFiles/Fonts/")
+BRACKET_PATH=os.path.join(PATHS, "DecompositionPlots/ReferenceFiles/Accolade_fermante.png")
 reportlab.rl_config.TTFSearchPath.append(FONTS_DIR)
 pdfmetrics.registerFont(TTFont('Arial-Bold', 'Arial Bold.ttf'))
 
@@ -124,44 +124,44 @@ def plot_1(bases, project, c_draw, denovo_plots_dict, basis_plots_dict):
 	for i in range(0,1):
 		image=basis_plots_dict[bases[i][0]]
 		c_draw.drawImage(image, LAYOUT_1_GRAPH[i][X_COORD], LAYOUT_1_GRAPH[i][Y_COORD], width=WIDTH_GRAPH, height=HEIGHT_GRAPH)
-		c_draw.drawString(LAYOUT_1_TEXT[i][X_COORD], LAYOUT_1_TEXT[i][Y_COORD], str(bases[i][1]) + "%")
+		c_draw.drawString(LAYOUT_1_TEXT[i][X_COORD], LAYOUT_1_TEXT[i][Y_COORD], str(float("{0:.2f}".format(bases[i][1]))) + "%")
 
 def plot_2(bases, project, c_draw, denovo_plots_dict, basis_plots_dict):
 	for i in range(0,2):
 		image=basis_plots_dict[bases[i][0]]
 		c_draw.drawImage(image, LAYOUT_2_GRAPH[i][X_COORD], LAYOUT_2_GRAPH[i][Y_COORD], width=WIDTH_GRAPH, height=HEIGHT_GRAPH)
-		c_draw.drawString(LAYOUT_2_TEXT[i][X_COORD], LAYOUT_2_TEXT[i][Y_COORD], str(bases[i][1]) + "%")
+		c_draw.drawString(LAYOUT_2_TEXT[i][X_COORD], LAYOUT_2_TEXT[i][Y_COORD], str(float("{0:.2f}".format(bases[i][1]))) + "%")
 
 def plot_3(bases, project, c_draw, denovo_plots_dict, basis_plots_dict):
 
 	for i in range(0,3):
 		image=basis_plots_dict[bases[i][0]]
 		c_draw.drawImage(image, LAYOUT_3_GRAPH[i][X_COORD], LAYOUT_3_GRAPH[i][Y_COORD], width=WIDTH_GRAPH, height=HEIGHT_GRAPH)
-		c_draw.drawString(LAYOUT_3_TEXT[i][X_COORD], LAYOUT_3_TEXT[i][Y_COORD], str(bases[i][1]) + "%")
+		c_draw.drawString(LAYOUT_3_TEXT[i][X_COORD], LAYOUT_3_TEXT[i][Y_COORD], str(float("{0:.2f}".format(bases[i][1]))) + "%")
 
 def plot_4(bases, project, c_draw, denovo_plots_dict, basis_plots_dict):
 	for i in range(0,4):
 		image=basis_plots_dict[bases[i][0]]
 		c_draw.drawImage(image, LAYOUT_4_GRAPH[i][X_COORD], LAYOUT_4_GRAPH[i][Y_COORD], width=WIDTH_GRAPH, height=HEIGHT_GRAPH)
-		c_draw.drawString(LAYOUT_4_TEXT[i][X_COORD], LAYOUT_4_TEXT[i][Y_COORD], str(bases[i][1]) + "%")
+		c_draw.drawString(LAYOUT_4_TEXT[i][X_COORD], LAYOUT_4_TEXT[i][Y_COORD], str(float("{0:.2f}".format(bases[i][1]))) + "%")
 
 def plot_5(bases, project, c_draw, denovo_plots_dict, basis_plots_dict):
 	for i in range(0,5):
 		image=basis_plots_dict[bases[i][0]]
 		c_draw.drawImage(image, LAYOUT_5_GRAPH[i][X_COORD], LAYOUT_5_GRAPH[i][Y_COORD], width=WIDTH_GRAPH, height=HEIGHT_GRAPH)
-		c_draw.drawString(LAYOUT_5_TEXT[i][X_COORD], LAYOUT_5_TEXT[i][Y_COORD], str(bases[i][1]) + "%")
+		c_draw.drawString(LAYOUT_5_TEXT[i][X_COORD], LAYOUT_5_TEXT[i][Y_COORD], str(float("{0:.2f}".format(bases[i][1]))) + "%")
 
 def plot_6_plus(bases, project, c_draw, denovo_plots_dict, basis_plots_dict):
 	for i in range(0,5):
 		image=basis_plots_dict[bases[i][0]]
 		c_draw.drawImage(image, LAYOUT_5_GRAPH[i][X_COORD], LAYOUT_5_GRAPH[i][Y_COORD], width=WIDTH_GRAPH, height=HEIGHT_GRAPH)
-		c_draw.drawString(LAYOUT_5_TEXT[i][X_COORD], LAYOUT_5_TEXT[i][Y_COORD], str(bases[i][1]) + "%")
+		c_draw.drawString(LAYOUT_5_TEXT[i][X_COORD], LAYOUT_5_TEXT[i][Y_COORD], str(float("{0:.2f}".format(bases[i][1]))) + "%")
 
 	extra_sigs = "* "
 	for i in range(5, len(bases)-1):
-		extra_sigs += str(bases[i][0]) + " (" + str(bases[i][1]) + "%), "
+		extra_sigs += str(bases[i][0]) + " (" + str(float("{0:.2f}".format(bases[i][1]))) + "%), "
 
-	extra_sigs += bases[len(bases)-1][0] + " (" + str(bases[len(bases)-1][1]) + "%)"
+	extra_sigs += bases[len(bases)-1][0] + " (" + str(float("{0:.2f}".format(bases[len(bases)-1][1]))) + "%)"
 	c_draw.drawString(GRAPH_X_COORD, (TEXT_Y_COORD - HEIGHT_GRAPH * 6) - 10, extra_sigs)
 
 # Helper function to add calculations to layout
@@ -176,22 +176,22 @@ def draw_statistics(c_draw, statistics, sig_version, custom_text):
 	kl_divergence = statistics["KL Divergence"][0]
 
 
-	c_draw.drawString(WIDTH_GAP+15, LAYOUT_2_TEXT[1][Y_COORD]-90, \
-		"Cosine Similarity: " + str(cos_sim))
-	c_draw.drawString(WIDTH_GAP+15, LAYOUT_2_TEXT[1][Y_COORD]-100, \
-		"Correlation: " + str(cor_coeff))
-	c_draw.drawString(WIDTH_GAP+105, LAYOUT_2_TEXT[1][Y_COORD]-90, \
-		"L1 Error %: " + str(l1_norm_percent) + "%")
-	c_draw.drawString(WIDTH_GAP+105, LAYOUT_2_TEXT[1][Y_COORD]-100, \
-		"L2 Error %: " + str(l2_norm_percent) + "%")
-	c_draw.drawString(WIDTH_GAP+195, LAYOUT_2_TEXT[1][Y_COORD]-90, \
-		"KL Divergence: " + str(kl_divergence))
+	c_draw.drawString(WIDTH_GAP+15, LAYOUT_2_TEXT[1][Y_COORD]-90,
+		"Cosine Similarity: " + str(float("{0:.3f}".format(cos_sim))))
+	c_draw.drawString(WIDTH_GAP+15, LAYOUT_2_TEXT[1][Y_COORD]-100,
+		"Correlation: " + str(float("{0:.3f}".format(cor_coeff))))
+	c_draw.drawString(WIDTH_GAP+105, LAYOUT_2_TEXT[1][Y_COORD]-90,
+		"L1 Error %: " + str(float("{0:.2f}".format(l1_norm_percent))) + "%")
+	c_draw.drawString(WIDTH_GAP+105, LAYOUT_2_TEXT[1][Y_COORD]-100,
+		"L2 Error %: " + str(float("{0:.2f}".format(l2_norm_percent))) + "%")
+	c_draw.drawString(WIDTH_GAP+195, LAYOUT_2_TEXT[1][Y_COORD]-90,
+		"KL Divergence: " + str(float("{0:.3f}".format(kl_divergence))))
 
 	if sig_version is not None:
-		c_draw.drawString(WIDTH_GAP+195, LAYOUT_2_TEXT[1][Y_COORD]-100, \
+		c_draw.drawString(WIDTH_GAP+195, LAYOUT_2_TEXT[1][Y_COORD]-100,
 			"Signature Version: " + str(sig_version))
 	if custom_text is not None:
-		c_draw.drawString(WIDTH_GAP+15, LAYOUT_2_TEXT[1][Y_COORD]-120, \
+		c_draw.drawString(WIDTH_GAP+15, LAYOUT_2_TEXT[1][Y_COORD]-120,
 			str(custom_text))
 
 # Helper function to resize bracket depending on number of bases plotted
diff --git a/SigProfilerAssignment/DecompositionPlots/reference_files/Accolade_fermante.png b/SigProfilerAssignment/DecompositionPlots/ReferenceFiles/Accolade_fermante.png
similarity index 100%
rename from SigProfilerAssignment/DecompositionPlots/reference_files/Accolade_fermante.png
rename to SigProfilerAssignment/DecompositionPlots/ReferenceFiles/Accolade_fermante.png
diff --git a/SigProfilerAssignment/DecompositionPlots/reference_files/CREDIT.md b/SigProfilerAssignment/DecompositionPlots/ReferenceFiles/CREDIT.md
similarity index 100%
rename from SigProfilerAssignment/DecompositionPlots/reference_files/CREDIT.md
rename to SigProfilerAssignment/DecompositionPlots/ReferenceFiles/CREDIT.md
diff --git a/SigProfilerAssignment/DecompositionPlots/reference_files/Fonts/Arial Bold.ttf b/SigProfilerAssignment/DecompositionPlots/ReferenceFiles/Fonts/Arial Bold.ttf
similarity index 100%
rename from SigProfilerAssignment/DecompositionPlots/reference_files/Fonts/Arial Bold.ttf
rename to SigProfilerAssignment/DecompositionPlots/ReferenceFiles/Fonts/Arial Bold.ttf
diff --git a/SigProfilerAssignment/decompose_subroutines.py b/SigProfilerAssignment/decompose_subroutines.py
index e33e8d5..81d97bd 100644
--- a/SigProfilerAssignment/decompose_subroutines.py
+++ b/SigProfilerAssignment/decompose_subroutines.py
@@ -384,24 +384,27 @@ def signature_decomposition(signatures, mtype, directory, genome_build="GRCh37",
             mtype_par="48"
         else:
             mtype_par="none"
-        try:
-            if mtype_par!="none" and make_decomposition_plots==True:
-                # Get the names of the columns for each dataframe
-                denovo_col_names = originalProcessAvg.columns
-                cosmic_col_names = sigDatabases_DF.columns
-                # Get the name for the MutationType column
-                cosmic_mut_types_col = cosmic_col_names[0]
-                denovo_mut_types_col =  denovo_col_names[0]
-                # create lists of implemented columns
-                basis_cols = basis_names.copy()
-                basis_cols.insert(0,cosmic_mut_types_col)
-                denovo_cols=[denovo_mut_types_col, denovo_name]
-                byte_plot = sp.run_PlotDecomposition(originalProcessAvg[denovo_cols], denovo_name, sigDatabases_DF[basis_cols], basis_names, weights, nonzero_exposures/5000, directory, "test", mtype_par)
-                merger.append(byte_plot)
-                with alive_bar(1, ctrl_c=False,bar='blocks', title=f'Decompositon Plot:{denovo_name}') as bar:
-                    bar()
-        except:
-            print("The context-" + str(mtype_par) + " decomposition plots pages were not able to be generated.")
+        # try:
+        if mtype_par!="none" and make_decomposition_plots==True:
+            # reformat the first column of cosmic signature dataframe
+            cosmic_sigs_DF = sigDatabases_DF.copy(deep=True)
+            cosmic_sigs_DF.columns = ["MutationType"] + cosmic_sigs_DF.columns[1:].to_list()
+            # Get the names of the columns for each dataframe
+            denovo_col_names = originalProcessAvg.columns
+            cosmic_col_names = cosmic_sigs_DF.columns
+            # Get the name for the MutationType column
+            cosmic_mut_types_col = cosmic_col_names[0]
+            denovo_mut_types_col =  denovo_col_names[0]
+            # create lists of implemented columns
+            basis_cols = basis_names.copy()
+            basis_cols.insert(0,cosmic_mut_types_col)
+            denovo_cols=[denovo_mut_types_col, denovo_name]
+            byte_plot = sp.run_PlotDecomposition(originalProcessAvg[denovo_cols], denovo_name, cosmic_sigs_DF[basis_cols], basis_names, weights, nonzero_exposures/5000, directory, "test", mtype_par)
+            merger.append(byte_plot)
+            with alive_bar(1, ctrl_c=False,bar='blocks', title=f'Decompositon Plot:{denovo_name}') as bar:
+                bar()
+        # except:
+        #     print("The context-" + str(mtype_par) + " decomposition plots pages were not able to be generated.")
         
         strings ="Signature %s-%s,"+" Signature %s (%0.2f%s) &"*(len(np.nonzero(exposures)[0])-1)+" Signature %s (%0.2f%s), %0.2f,  %0.2f, %0.3f, %0.2f, %0.2f\n" 
         #new_signature_thresh_hold = 0.8
diff --git a/SigProfilerAssignment/decomposition.py b/SigProfilerAssignment/decomposition.py
index bef683c..bad4772 100644
--- a/SigProfilerAssignment/decomposition.py
+++ b/SigProfilerAssignment/decomposition.py
@@ -9,23 +9,109 @@
 #from SigProfilerExtractor import subroutines as sub
 
 from cmath import cos
+import datetime
+import platform
 
 # from torch import sign
 from SigProfilerAssignment import decompose_subroutines as sub
+from SigProfilerAssignment.DecompositionPlots import PlotDecomposition as plot_decomp
+import SigProfilerAssignment
+
 import numpy as np
 import pandas as pd
 import SigProfilerMatrixGenerator
 from SigProfilerMatrixGenerator.scripts import SigProfilerMatrixGeneratorFunc as datadump 
 from SigProfilerMatrixGenerator.scripts import CNVMatrixGenerator as scna
-
-#import SigProfilerExtractor as cosmic
+import sigProfilerPlotting
 import os,sys
+from PyPDF2 import PdfFileMerger
+import fitz
+import time
+
+def convert_PDF_to_PNG(input_file_name, output_directory, page_names):
+    pdf_doc = fitz.open(input_file_name)
+    zoom = 3
+    magnify = fitz.Matrix(zoom, zoom)
+    
+    if pdf_doc.page_count != len(page_names):
+        raise ValueError("Error: The number of samples and number of plots do not match.")
+    if not os.path.exists(output_directory):
+        os.makedirs(output_directory)
+    
+    for sample_name, page in zip(page_names, pdf_doc):
+        pix = page.get_pixmap(matrix=magnify)
+        out_file_name = os.path.join(output_directory, sample_name+  ".png")
+        pix.save(out_file_name)
+
+# Create sample reconstruction plots
+def generate_sample_reconstruction(cosmic_sigs, samples_input, activities, output_dir):
+    project = "test_run"
+    mtype="96"
+
+    final_pdf = PdfFileMerger()
+    samples = samples_input.copy(deep=True)
+    samples.reset_index(inplace=True)
+    for sample_name in samples.columns[1:]:
+        # basis names and their corresponding weights
+        subset = activities[activities["Samples"].str.contains(sample_name)]
+        subset = subset.loc[:, (subset != 0).any(axis=0)]
+        basis_names = subset[subset["Samples"].str.contains(sample_name)].columns[1:].tolist()
+        recon_tmb = subset.sum(axis=1)
+        weights = []
+        for i in range(len(basis_names)):
+            weights.append(str(float("{0:.6f}".format(100*int(subset[basis_names[i]])/int(recon_tmb))))+"%")
+
+        names_copy = basis_names.copy()
+        names_copy.insert(0, cosmic_sigs.columns[0])
+        result = plot_decomp.run_PlotSSDecomposition(
+                    samples[[samples.columns[0],sample_name]],
+                    sample_name,
+                    cosmic_sigs[names_copy],
+                    basis_names,
+                    weights,
+                    output_dir,
+                    project,
+                    mtype)
+        final_pdf.append(result)
+    
+    pdf_output_path = os.path.join(output_dir,
+            "Reconstructed_Sample_Plots_" + str(mtype) + ".pdf")
+    web_png_path = os.path.join(output_dir,"WebPNGs")
+
+    final_pdf.write(pdf_output_path)
 
+    convert_PDF_to_PNG(pdf_output_path, web_png_path, samples.columns[1:])
+    
+    return pdf_output_path
+
+def record_parameters(sysdata,execution_parameters,start_time):
+    sysdata.write("\n--------------EXECUTION PARAMETERS--------------\n")
+    sysdata.write("INPUT DATA\n")
+    sysdata.write("\tinput_type: {}\n".format(execution_parameters["input_type"]))
+    sysdata.write("\toutput: {}\n".format(execution_parameters["output"]))
+    sysdata.write("\tsamples: {}\n".format(execution_parameters["samples"]))
+    sysdata.write("\treference_genome: {}\n".format(execution_parameters["reference_genome"]))
+    sysdata.write("\tcontext_types: {}\n".format(execution_parameters["context_type"]))
+    sysdata.write("\texome: {}\n".format(execution_parameters["exome"]))
+
+    sysdata.write("COSMIC MATCH\n")
+    sysdata.write("\tcosmic_version: {}\n".format(execution_parameters["cosmic_version"]))
+    sysdata.write("\tnnls_add_penalty: {}\n".format(execution_parameters["nnls_add_penalty"]))
+    sysdata.write("\tnnls_remove_penalty: {}\n".format(execution_parameters["nnls_remove_penalty"]))
+    sysdata.write("\tinitial_remove_penalty: {}\n".format(execution_parameters["initial_remove_penalty"]))
+    sysdata.write("\tde_novo_fit_penalty: {}\n".format(execution_parameters["de_novo_fit_penalty"]))
+    sysdata.write("\texport_probabilities: {}\n".format(execution_parameters["export_probabilities"]))
+    sysdata.write("\tcollapse_to_SBS96: {}\n".format(execution_parameters["collapse_to_SBS96"]))
+    sysdata.write("\tdenovo_refit_option: {}\n".format(execution_parameters["denovo_refit_option"]))
+    sysdata.write("\tdecompose_fit_option: {}\n".format(execution_parameters["decompose_fit_option"]))
+    sysdata.write("\tcosmic_fit_option: {}\n".format(execution_parameters["cosmic_fit_option"]))
+    sysdata.write("\n-------Analysis Progress------- \n")
+    sysdata.write("[{}] Analysis started: \n".format(str(start_time).split(".")[0]))
 
 def spa_analyze(samples, output, input_type='matrix', context_type="96", signatures=None, signature_database=None,decompose_fit_option= True,denovo_refit_option=True,cosmic_fit_option=True, nnls_add_penalty=0.05, 
               nnls_remove_penalty=0.01, initial_remove_penalty=0.05, de_novo_fit_penalty=0.02, 
               genome_build="GRCh37", cosmic_version=3.3, make_plots=True, collapse_to_SBS96=True,connected_sigs=True, verbose=False,devopts=None,new_signature_thresh_hold=0.8,
-              exclude_signature_subgroups=None, exome=False, export_probabilities=True, export_probabilities_per_mutation=False):
+              exclude_signature_subgroups=None, exome=False, export_probabilities=True, export_probabilities_per_mutation=False, sample_reconstruction_plots=False):
 
     
     """
@@ -169,11 +255,49 @@ def spa_analyze(samples, output, input_type='matrix', context_type="96", signatu
     except:
         print ("The {} folder could not be created".format("output"))
 
+    start_time = datetime.datetime.now() # start time
+
+    # create JOB_METADATA
+    sysdata = open(output+"/JOB_METADATA.txt", "w")
+    sysdata.write("THIS FILE CONTAINS THE METADATA ABOUT SYSTEM AND RUNTIME\n\n\n")
+    sysdata.write("-------System Info-------\n")
+    sysdata.write("Operating System Name: "+ platform.uname()[0]+"\n"+"Nodename: "+platform.uname()[1]+"\n"+"Release: "+platform.uname()[2]+"\n"+"Version: "+platform.uname()[3]+"\n")
+    sysdata.write("\n-------Python and Package Versions------- \n")
+    sysdata.write("Python Version: "+str(platform.sys.version_info.major)+"."+str(platform.sys.version_info.minor)+"."+str(platform.sys.version_info.micro)+"\n")
+    sysdata.write("SigProfilerPlotting Version: "+sigProfilerPlotting.__version__+"\n")
+    sysdata.write("SigProfilerMatrixGenerator Version: "+SigProfilerMatrixGenerator.__version__+"\n")
+    sysdata.write("SigProfilerAssignment Version: "+SigProfilerAssignment.__version__+"\n")
+    sysdata.write("Pandas version: "+pd.__version__+"\n")
+    sysdata.write("Numpy version: "+np.__version__+"\n")
+    execution_parameters = {"input_type":input_type,
+                        "context_type":context_type,
+                        "signatures":signatures, 
+                        "signature_database":signature_database,
+                        "denovo_refit_option":denovo_refit_option,
+                        "decompose_fit_option":decompose_fit_option,
+                        "cosmic_fit_option":cosmic_fit_option, 
+                        "output":output, 
+                        "samples":samples, 
+                        "reference_genome":genome_build, 
+                        "cosmic_version":cosmic_version,
+                        "context_type":context_type,
+                        "exome":exome, 
+                        "nnls_add_penalty":nnls_add_penalty,
+                        "nnls_remove_penalty":nnls_remove_penalty,
+                        "initial_remove_penalty":initial_remove_penalty,
+                        "de_novo_fit_penalty":de_novo_fit_penalty,
+                        "collapse_to_SBS96":collapse_to_SBS96,
+                        "export_probabilities":export_probabilities,
+                        "make_plots":make_plots
+                        }
+    record_parameters(sysdata,execution_parameters,start_time)
+    sysdata.close()
     # Add sequence parameter to control the tmbplot y-axis scale
     if exome == True:
         sequence = 'exome'
     else:
         sequence = 'genome'
+    
 
                                                                 #################
                                                                 # Denovo refiting #
@@ -237,7 +361,12 @@ def spa_analyze(samples, output, input_type='matrix', context_type="96", signatu
         listOfSignatures = sub.make_letter_ids(idlenth = processAvg.shape[1], mtype=mutation_context)
         genomes = pd.DataFrame(genomes)
         denovo_exposureAvg = np.array(exposureAvg.T)
-        print("\n Denovo Fitting .....")
+        print("\n De Novo Fitting .....")
+        current_time_start = datetime.datetime.now()
+        with open(output+"JOB_METADATA.txt","a") as sysdata:
+            sysdata.write("\n De Novo Fitting .....")
+
+
         #exposureAvg = sub.make_final_solution(processAvg, genomes, listOfSignatures, layer_directory1, mutation_type, index,\
                    # colnames,denovo_exposureAvg  = denovo_exposureAvg, add_penalty=nnls_add_penalty, remove_penalty=nnls_remove_penalty, initial_remove_penalty=initial_remove_penalty, de_novo_fit_penalty=de_novo_fit_penalty, connected_sigs=connected_sigs, refit_denovo_signatures=refit_denovo_signatures)    
                    # 
@@ -277,7 +406,12 @@ def spa_analyze(samples, output, input_type='matrix', context_type="96", signatu
                                     add_penalty=nnls_add_penalty, remove_penalty=nnls_remove_penalty, process_std_error = processSTE, signature_stabilities = signature_stabilities,
                                     initial_remove_penalty=init_rem_denovo,connected_sigs=connected_sigs,refit_denovo_signatures=True,export_probabilities=export_probabilities,
                                     export_probabilities_per_mutation=export_probabilities_per_mutation, samples=samples, input_type=input_type, denovo_refit_option=denovo_refit_option)
+        
+        with open(output+"JOB_METADATA.txt","a") as sysdata:
+            current_time_end = datetime.datetime.now()
 
+            sysdata.write(f"\n Finished Denovo fitting! \nExecution time:{str(current_time_end-current_time_start)}\n")
+        
 
                                                                 #################
                                                                 # Decomposition       
@@ -295,12 +429,14 @@ def spa_analyze(samples, output, input_type='matrix', context_type="96", signatu
             listOfSignatures = processAvg.columns
             index = genomes.index
             colnames = genomes.columns
+            make_decomposition_plots=make_plots
         else:
             listOfSignatures=devopts['listOfSignatures']
             index=devopts['index']
             colnames=devopts['colnames']
             genomes = genomes.set_index(index)
             genomes.columns = colnames
+            make_decomposition_plots = devopts['make_decomposition_plots']
             #genomes = genomes.rename_axis("Mutation Types", axis="columns")
 
         #creating list of mutational type to sync with the vcf type input
@@ -352,7 +488,10 @@ def spa_analyze(samples, output, input_type='matrix', context_type="96", signatu
             processAvg = np.array(processAvg)
                 
         print("\n Decomposing De Novo Signatures  .....")
-        final_signatures = sub.signature_decomposition(processAvg, mutation_type, layer_directory2, genome_build=genome_build,cosmic_version=cosmic_version,signature_database=signature_database, mutation_context=mutation_context, add_penalty=0.05, connected_sigs=connected_sigs,remove_penalty=0.01, make_decomposition_plots=make_plots, originalProcessAvg=originalProcessAvg,new_signature_thresh_hold=new_signature_thresh_hold,sig_exclusion_list=sig_exclusion_list,exome=exome, m_for_subgroups=m_for_subgroups)    
+        current_time_start = datetime.datetime.now()
+        with open(output+"JOB_METADATA.txt","a") as sysdata:
+            sysdata.write("\n Decomposing De Novo Signatures  .....")
+        final_signatures = sub.signature_decomposition(processAvg, mutation_type, layer_directory2, genome_build=genome_build,cosmic_version=cosmic_version,signature_database=signature_database, mutation_context=mutation_context, add_penalty=0.05, connected_sigs=connected_sigs,remove_penalty=0.01, make_decomposition_plots=make_decomposition_plots, originalProcessAvg=originalProcessAvg,new_signature_thresh_hold=new_signature_thresh_hold,sig_exclusion_list=sig_exclusion_list,exome=exome, m_for_subgroups=m_for_subgroups)    
         #final_signatures = sub.signature_decomposition(processAvg, m, layer_directory2, genome_build=genome_build)
         # extract the global signatures and new signatures from the final_signatures dictionary
         globalsigs = final_signatures["globalsigs"]
@@ -366,6 +505,9 @@ def spa_analyze(samples, output, input_type='matrix', context_type="96", signatu
         colnames = genomes.columns
 
         print("\n Assigning decomposed signature")
+        with open(output+"JOB_METADATA.txt","a") as sysdata:
+            sysdata.write("\n [{}] Assigning decomposed signature \n".format(str(start_time).split(".")[0]))
+            
         result = sub.make_final_solution(processAvg, genomes, allsigids, layer_directory2, mutation_type, index, colnames, 
                                 cosmic_sigs=True, attribution = attribution, denovo_exposureAvg  = exposureAvg, sequence=sequence,  
                                 background_sigs=background_sigs, verbose=verbose, genome_build=genome_build, 
@@ -378,7 +520,10 @@ def spa_analyze(samples, output, input_type='matrix', context_type="96", signatu
                                 export_probabilities_per_mutation=export_probabilities_per_mutation,
                                 samples=samples, input_type=input_type, denovo_refit_option=denovo_refit_option)
 
+        with open(output+"JOB_METADATA.txt","a") as sysdata:
+            current_time_end = datetime.datetime.now()
 
+            sysdata.write(f"\n Finished Decompose fitting! \nExecution time:{str(current_time_end-current_time_start)}\n")
                                                                 #################
                                                                 # Cosmic Fitting       
                                                                 #################
@@ -422,22 +567,22 @@ def spa_analyze(samples, output, input_type='matrix', context_type="96", signatu
 
         if signature_database==None:
             processAvg = sub.getProcessAvg(genomes, genome_build=genome_build, cosmic_version=cosmic_version, exome=exome)[0]
-            #processAvg = processAvg.set_index('Type').rename_axis('MutationType')
+            # for sample reconstruction plots
+            cosmic_sig_ref = processAvg.copy(deep=True)
+            cosmic_sig_ref.reset_index(inplace=True)
         else:
             try:
                 processAvg = pd.read_csv(signature_database,sep='\t', index_col=0)
             except:
                 sys.exit("Something is wrong with the format of signature database, Pass a text file of signatures in the format of COSMIC sig database")
         
-
-
-        if processAvg.shape[0]==1536 and collapse_to_SBS96==True: #collapse the 1596 context into 96 only for the deocmposition 
+        # collapse the 1596 context into 96 only for the decomposition
+        if processAvg.shape[0]==1536 and collapse_to_SBS96==True:
             processAvg = pd.DataFrame(processAvg, index=index)
             processAvg = processAvg.groupby(processAvg.index.str[1:8]).sum()
             genomes = pd.DataFrame(genomes, index=index)
             genomes = genomes.groupby(genomes.index.str[1:8]).sum()
             index = genomes.index
-            #processAvg = np.array(processAvg)
         
         if processAvg.shape[0]==288 and collapse_to_SBS96==True: #collapse the 288 context into 96 only for the deocmposition 
             processAvg = pd.DataFrame(processAvg, index=index)
@@ -445,10 +590,7 @@ def spa_analyze(samples, output, input_type='matrix', context_type="96", signatu
             genomes = pd.DataFrame(genomes, index=index)
             genomes = genomes.groupby(genomes.index.str[2:9]).sum()
             index = genomes.index
-            #processAvg = np.array(processAvg)
-
-        
-        
+   
 
         #processAvg is sigdatabase: remove sigs corresponding to exclusion rules.
         sig_exclusion_list= [m_for_subgroups+items for items in sig_exclusion_list]
@@ -475,7 +617,9 @@ def spa_analyze(samples, output, input_type='matrix', context_type="96", signatu
             background_sigs = []
         exposureAvg_dummy = pd.DataFrame(np.random.rand(processAvg.shape[1],genomes.shape[1]),index=allsigids,columns=colnames.to_list()).transpose().rename_axis('Samples')
         print("Assigning COSMIC sigs or Signature Database ...... ")
-       
+        current_time_start = datetime.datetime.now()
+        with open(output+"JOB_METADATA.txt","a") as sysdata:
+            sysdata.write("\n Assigning COSMIC sigs or Signature Database ...... ")
         if processAvg.shape[0] != 96:
             if genomes.shape[0] == processAvg.shape[0] and collapse_to_SBS96 ==True:
                 sys.exit("Signatures Database and Samples are of same context type and is not equal to 96. please rerun by setting the flag \"collapse_to_SBS96 = False \"")
@@ -492,7 +636,40 @@ def spa_analyze(samples, output, input_type='matrix', context_type="96", signatu
                             export_probabilities=export_probabilities,
                             export_probabilities_per_mutation=export_probabilities_per_mutation,
                             samples=samples, input_type=input_type, denovo_refit_option=denovo_refit_option)
-   
+        
+        with open(output+"JOB_METADATA.txt","a") as sysdata:
+            current_time_end = datetime.datetime.now()
+
+            sysdata.write(f"\n Finished Cosmic fitting! \nExecution time:{str(current_time_end-current_time_start)}\n")
+    
+    # Generate sample reconstruction plots
+    if sample_reconstruction_plots and context_type == "96":
+        ss_recon_odir = os.path.join(
+                    layer_directory3,
+                    "Activities",
+                    "SampleReconstruction")
+        if not os.path.exists(ss_recon_odir):
+            os.makedirs(ss_recon_odir)
+        acts_path = os.path.join(
+                layer_directory3,
+                "Activities",
+                "Assignment_Solution_Activities.txt")
+        cosmic_activities = pd.read_csv(acts_path, sep="\t")
+        # Create sample reconstruction plots
+        generate_sample_reconstruction(cosmic_sig_ref,
+                                        genomes,
+                                        cosmic_activities,
+                                        ss_recon_odir)
+
+    # Complete JOB_METADATA
+    sysdata = open(output+"/JOB_METADATA.txt", "a")
+    end_time = datetime.datetime.now()
+    sysdata.write("\n[{}] Analysis ended: \n".format(str(end_time).split(".")[0]))
+    sysdata.write("\n-------Job Status------- \n")
+    sysdata.write("Assignment of mutational signatures completed successfully! \nTotal execution time: "+str(end_time-start_time).split(".")[0]+" \nResults can be found in: "+" "+output+ " " +" folder")
+    sysdata.close()
+
+    print("\n\n \nYour Job Is Successfully Completed! Thank You For Using SigProfilerAssignment.\n ")
   
 
 
diff --git a/requirements.txt b/requirements.txt
index 5e2c2b6..580383d 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,7 +1,6 @@
 scipy
 numpy
 pandas 
-SigProfilerExtractor 
 SigProfilerMatrixGenerator 
 sigProfilerPlotting 
 pillow
diff --git a/setup.py b/setup.py
index be54e23..f7a8ce0 100644
--- a/setup.py
+++ b/setup.py
@@ -6,10 +6,8 @@
 if os.path.exists("dist"):
     shutil.rmtree("dist")
 
-VERSION = '0.0.19'
+VERSION = '0.0.20'
 
-with open('README.md') as f:
-	long_description = f.read()
 
 def write_version_py(filename='SigProfilerAssignment/version.py'):
     # Copied from numpy setup.py
@@ -17,28 +15,36 @@ def write_version_py(filename='SigProfilerAssignment/version.py'):
 # THIS FILE IS GENERATED FROM SigProfilerAssignment SETUP.PY
 short_version = '%(version)s'
 version = '%(version)s'
-Update = '(1) Add probabilities per mutation'
+Update = 'Implement sample reconstruction plot'
+
     
     """
     fh = open(filename, 'w')
     fh.write(cnt % {'version': VERSION,})
     fh.close()
+
+with open('README.md') as f:
+	long_description = f.read()
+
 requirements=[
           'scipy>=1.6.3',
           'numpy>=1.21.2',
           'pandas>=1.2.4',
           'SigProfilerMatrixGenerator>=1.2.13', 
-          'sigProfilerPlotting>=1.3.2', 
-          'pillow',
+          'sigProfilerPlotting>=1.3.6', 
+          'pillow>=9.1.1',
           'statsmodels>=0.9.0',
           'scikit-learn>=0.24.2',
           'psutil>=5.6.1',
           'reportlab>=3.5.42',
           'PyPDF2>=1.26.0',
-          'alive_progress'
+          'alive_progress>=2.4.1',
+          'PyPDf2>=1.28.4',
+          'pdf2image>=1.16.0',
+          'PyMuPDF>=1.21.0'
            ]
-    
-write_version_py()
+
+write_version_py() 
 setup(name='SigProfilerAssignment',
       version=VERSION,
       description='Mutational signatures attribution and decomposition tool',


Test patch:
diff --git a/test.py b/test.py
index 71cb095..7ebfa0b 100644
--- a/test.py
+++ b/test.py
@@ -7,10 +7,16 @@
 
 import SigProfilerAssignment as spa
 from SigProfilerAssignment import Analyzer as Analyze
+from SigProfilerAssignment.DecompositionPlots import PlotDecomposition as sp
+from PyPDF2 import PdfFileMerger
+import numpy as np
+import pandas as pd
+import time
 import os
+
 DIR_INPUT = spa.__path__[0]+'/data/tests/'
-OUTPUT_TXT = "output_txt_example/"
-OUTPUT_VCF = "output_vcf_example/"
+OUTPUT_TXT = "TestOutput/output_txt_example/"
+OUTPUT_VCF = "TestOutput/output_vcf_example/"
 SIGNATURES_TXT = os.path.join(DIR_INPUT, "txt_input/SBS96_S3_Signatures.txt")
 SAMPLES_TXT = os.path.join(DIR_INPUT, "txt_input/sample_matrix.txt")
 SAMPLES_VCF = os.path.join(DIR_INPUT, "vcf_input/")
@@ -24,7 +30,8 @@ def cosmic_fit_txt_test():
         genome_build="GRCh37",
         verbose=False,
         collapse_to_SBS96=True,
-        exclude_signature_subgroups=exclude_signature_subgroups)
+        exclude_signature_subgroups=exclude_signature_subgroups,
+        sample_reconstruction_plots=True)
 
 def denovo_fit_txt_test():
     Analyze.denovo_fit(SAMPLES_TXT,
@@ -78,10 +85,249 @@ def denovo_fit_vcf_test():
         make_plots=True,
         input_type="vcf")
 
+################################################
+#           Decomposition Plot Tests           #
+################################################
+def gen_SBS96():
+    np.random.seed(1234567)
+    s = time.time()
+    merger = PdfFileMerger()
+    file1="SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_SBS96.txt"
+    file2="SigProfilerAssignment/DecompositionPlots/ExampleSample/Decomposed_Solution_Signatures_SBS96.txt"
+    denovo_mtx = pd.read_csv(file1, sep="\t")
+    basis_mtx = pd.read_csv(file2, sep="\t")
+    output_path = "TestOutput/Results/"
+    project = "test_run"
+    mtype="96"
+
+    denovo_name="SBS96A"
+    basis_names=["SBS1", "SBS3", "SBS5", "SBS13", "SBS50", "SBS2"]
+    weights=["0.94%", "48.72%", "28.44%", "8.42%", "13.48%", "0%"]
+    denovo_cols = ["MutationType", "SBS96A"]
+    basis_cols=basis_names.copy()
+    basis_cols.insert(0, "MutationType")
+    nonzero_exposures=np.random.uniform(size=len(basis_names))
+    result = sp.run_PlotDecomposition(denovo_mtx[denovo_cols], denovo_name, basis_mtx[basis_cols], basis_names, weights, nonzero_exposures, output_path, project, mtype)
+    merger.append(result)
+
+    for ind in range(5, 0, -1):
+        basis_names=basis_names[:ind]
+        weights=weights[:ind]
+        denovo_cols = ["MutationType", "SBS96A"]
+        basis_cols=basis_names.copy()
+        basis_cols.insert(0, "MutationType")
+        nonzero_exposures=np.random.uniform(size=len(basis_names))
+        result = sp.run_PlotDecomposition(denovo_mtx[denovo_cols], denovo_name, basis_mtx[basis_cols], basis_names, weights, nonzero_exposures, output_path, project, mtype)
+        merger.append(result)
+
+    merger.write(os.path.join(output_path,"Result_Decomposition_Plots_SBS96.pdf"))
+    return(time.time() - s)
+
+
+def gen_SBS1536():
+    np.random.seed(1234567)
+    s = time.time()
+    merger = PdfFileMerger()
+    file1="SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_SBS1536.txt"
+    file2="SigProfilerAssignment/DecompositionPlots/ExampleSample/Decomposed_Solution_Signatures_SBS1536.txt"
+    denovo_mtx = pd.read_csv(file1, sep="\t")
+    basis_mtx = pd.read_csv(file2, sep="\t")
+    output_path = "TestOutput/Results/"
+    project = "test_run"
+    mtype="1536"
+
+    denovo_name="SBS1536A"
+    basis_names=["SBS1", "SBS2", "SBS5", "SBS13", "SBS15", "SBS18"]
+    weights=["0.94%", "48.72%", "28.44%", "8.42%", "13.48%", "0%"]
+    denovo_cols = ["MutationType", "SBS1536A"]
+    basis_cols=basis_names.copy()
+    basis_cols.insert(0, "MutationType")
+    nonzero_exposures=np.random.uniform(size=len(basis_names))
+    result = sp.run_PlotDecomposition(denovo_mtx[denovo_cols], denovo_name, basis_mtx[basis_cols], basis_names, weights, nonzero_exposures, output_path, project, mtype)
+    #sp.run_PlotDecomposition(denovo_mtx, basis_names, weights, output_path, project, mtype, True, statistics, "COSMICv3-GRCh37", "This is where a custom message would go.")
+    merger.append(result)
+
+    for ind in range(5, 0, -1):
+        basis_names=basis_names[:ind]
+        weights=weights[:ind]
+        denovo_cols = ["MutationType", "SBS1536A"]
+        basis_cols=basis_names.copy()
+        basis_cols.insert(0, "MutationType")
+        nonzero_exposures=np.random.uniform(size=len(basis_names))
+        result = sp.run_PlotDecomposition(denovo_mtx[denovo_cols], denovo_name, basis_mtx[basis_cols], basis_names, weights, nonzero_exposures, output_path, project, mtype)
+        merger.append(result)
+
+    merger.write(os.path.join(output_path,"Result_Decomposition_Plots_SBS1536.pdf"))
+    return(time.time() - s)
+
+
+def gen_SBS288():
+    np.random.seed(1234567)
+    s=time.time()
+    merger = PdfFileMerger()
+    file1="SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_SBS288.txt"
+    file2="SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_SBS288_Signatures.txt"
+    denovo_mtx = pd.read_csv(file1, sep="\t")
+    basis_mtx = pd.read_csv(file2, sep="\t")
+    output_path = "TestOutput/Results/"
+    project = "test_run"
+    mtype="288"
+
+    denovo_name="SBS288A"
+    basis_names=["SBS1", "SBS2", "SBS4", "SBS5", "SBS8", "SBS90"]
+    weights=["0.94%", "48.72%", "28.44%", "8.42%", "13.48%", "0%"]
+    denovo_cols = ["MutationType", "SBS288A"]
+    basis_cols=basis_names.copy()
+    basis_cols.insert(0, "MutationType")
+    nonzero_exposures=np.random.uniform(size=len(basis_names))
+    result = sp.run_PlotDecomposition(denovo_mtx[denovo_cols], denovo_name, basis_mtx[basis_cols], basis_names, weights, nonzero_exposures, output_path, project, mtype)
+    merger.append(result)
+
+    for ind in range(5, 0, -1):
+        basis_names=basis_names[:ind]
+        weights=weights[:ind]
+        denovo_cols = ["MutationType", "SBS288A"]
+        basis_cols=basis_names.copy()
+        basis_cols.insert(0, "MutationType")
+        nonzero_exposures=np.random.uniform(size=len(basis_names))
+        result = sp.run_PlotDecomposition(denovo_mtx[denovo_cols], denovo_name, \
+            basis_mtx[basis_cols], basis_names, weights, nonzero_exposures, output_path, project, mtype)
+        merger.append(result)
+
+    merger.write(os.path.join(output_path,"Result_Decomposition_Plots_SBS288.pdf"))
+    return(time.time() - s)
+
+def gen_ID83():
+    np.random.seed(1234567)
+    s = time.time()
+    merger = PdfFileMerger()
+    file1="SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_INDEL.txt"
+    file2="SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_ID83_Signatures.txt"
+    denovo_mtx = pd.read_csv(file1, sep="\t")
+    basis_mtx = pd.read_csv(file2, sep="\t")
+    output_path = "TestOutput/Results/"
+    project = "test_run"
+    mtype="83"
+
+    denovo_name="ID83A"
+    basis_names=["ID1", "ID2", "ID4", "ID5", "ID8", "ID9"]
+    weights=["0.94%", "48.72%", "28.44%", "8.42%", "13.48%", "0%"]
+    denovo_cols = ["MutationType", "ID83A"]
+    basis_cols=basis_names.copy()
+    basis_cols.insert(0, "MutationType")
+    nonzero_exposures=np.random.uniform(size=len(basis_names))
+    result = sp.run_PlotDecomposition(denovo_mtx[denovo_cols], denovo_name, \
+        basis_mtx[basis_cols], basis_names, weights, nonzero_exposures, output_path, project, mtype)
+    merger.append(result)
+
+    for ind in range(5, 0, -1):
+        basis_names=basis_names[:ind]
+        weights=weights[:ind]
+        denovo_cols = ["MutationType", "ID83A"]
+        basis_cols=basis_names.copy()
+        basis_cols.insert(0, "MutationType")
+        nonzero_exposures=np.random.uniform(size=len(basis_names))
+        result = sp.run_PlotDecomposition(denovo_mtx[denovo_cols], denovo_name, \
+            basis_mtx[basis_cols], basis_names, weights, nonzero_exposures, output_path, project, mtype)
+        merger.append(result)
+
+    merger.write(os.path.join(output_path,"Result_Decomposition_Plots_ID83.pdf"))
+    return(time.time() - s)
+
+def gen_DBS78():
+    np.random.seed(1234567)
+    s = time.time()
+    merger = PdfFileMerger()
+    file1="SigProfilerAssignment/DecompositionPlots/ExampleSample/De_Novo_Solution_Signatures_DINUC.txt"
+    file2="SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_DBS78_Signatures.txt"
+    denovo_mtx = pd.read_csv(file1, sep="\t")
+    basis_mtx = pd.read_csv(file2, sep="\t")
+    output_path = "TestOutput/Results/"
+    project = "test_run"
+    mtype="78"
+
+    denovo_name="DBS78A"
+    basis_names=["DBS1", "DBS2", "DBS4", "DBS5", "DBS8", "DBS9"]
+    weights=["0.94%", "48.72%", "28.44%", "8.42%", "13.48%", "0%"]
+    denovo_cols = ["MutationType", "DBS78A"]
+    basis_cols=basis_names.copy()
+    basis_cols.insert(0, "MutationType")
+    nonzero_exposures=np.random.uniform(size=len(basis_names))
+    result = sp.run_PlotDecomposition(denovo_mtx[denovo_cols], denovo_name, \
+        basis_mtx[basis_cols], basis_names, weights, nonzero_exposures, output_path, project, mtype)
+    merger.append(result)
+
+    for ind in range(5, 0, -1):
+        basis_names=basis_names[:ind]
+        weights=weights[:ind]
+        denovo_cols = ["MutationType", "DBS78A"]
+        basis_cols=basis_names.copy()
+        basis_cols.insert(0, "MutationType")
+        nonzero_exposures=np.random.uniform(size=len(basis_names))
+        result = sp.run_PlotDecomposition(denovo_mtx[denovo_cols], denovo_name, \
+            basis_mtx[basis_cols], basis_names, weights, nonzero_exposures, output_path, project, mtype)
+        merger.append(result)
+
+    merger.write(os.path.join(output_path,"Result_Decomposition_Plots_DBS78.pdf"))
+    return(time.time() - s)
+
+def gen_CNV48():
+    np.random.seed(1234567)
+    s = time.time()
+    merger = PdfFileMerger()
+    file1="SigProfilerAssignment/DecompositionPlots/ExampleSample/CNV48_De-Novo_Signatures.txt"
+    file2="SigProfilerAssignment/DecompositionPlots/ExampleSample/COSMIC_CNV48_Signatures.txt"
+    denovo_mtx = pd.read_csv(file1, sep="\t")
+    basis_mtx = pd.read_csv(file2, sep="\t")
+    output_path = "TestOutput/Results/"
+    project = "test_run"
+    mtype="48"
+
+    denovo_name="CNV48A"
+    basis_names=["CN1", "CN2", "CN9", "CN20", "CNV48B", "CNV48D"]
+    weights=["0.94%", "48.72%", "28.44%", "8.42%", "13.48%", "0%"]
+    denovo_cols = ["MutationType", "CNV48A"]
+    basis_cols=basis_names.copy()
+    basis_cols.insert(0, "MutationType")
+    nonzero_exposures=np.random.uniform(size=len(basis_names))
+    result = sp.run_PlotDecomposition(denovo_mtx[denovo_cols], denovo_name, basis_mtx[basis_cols], basis_names, weights, nonzero_exposures, output_path, project, mtype)
+    #sp.run_PlotDecomposition(denovo_mtx, basis_names, weights, output_path, project, mtype, True, statistics, "COSMICv3-GRCh37", "This is where a custom message would go.")
+    merger.append(result)
+
+    for ind in range(5, 0, -1):
+        basis_names=basis_names[:ind]
+        weights=weights[:ind]
+        denovo_cols = ["MutationType", "CNV48A"]
+        basis_cols=basis_names.copy()
+        basis_cols.insert(0, "MutationType")
+        nonzero_exposures=np.random.uniform(size=len(basis_names))
+        result = sp.run_PlotDecomposition(denovo_mtx[denovo_cols], denovo_name, basis_mtx[basis_cols], basis_names, weights, nonzero_exposures, output_path, project, mtype)
+        merger.append(result)
+
+    merger.write(os.path.join(output_path,"Result_Decomposition_Plots_CNV48.pdf"))
+    return(time.time() - s)
+
+
 if __name__ == '__main__':
+    print("Text input tests...")
     cosmic_fit_txt_test()
     denovo_fit_txt_test()
     decompose_fit_txt_test()
+    print("VCF input tests...")
     cosmic_fit_vcf_test()
     decompose_fit_vcf_test()
-    denovo_fit_vcf_test()
\ No newline at end of file
+    denovo_fit_vcf_test()
+
+    print("Decomposition Plot tests...")
+    time_96 = gen_SBS96()
+    print("Completed SBS96 plots in", time_96, "seconds.")
+    time_288 = gen_SBS288()
+    print("Completed SBS288 plots in", time_288, "seconds.")
+    time_1536 = gen_SBS1536()
+    print("Completed SBS1536 plots in", time_1536, "seconds.")
+    time_78 = gen_DBS78()
+    print("Completed DBS78 plots in", time_78, "seconds.")
+    time_83 = gen_ID83()
+    print("Completed ID83 plots in", time_83, "seconds.")
+    time_48 = gen_CNV48()
+    print("Completed CNV48 plots in", time_48, "seconds.")
\ No newline at end of file