Task: Named Entity Recognition
Input (English):  The point mutation Asp - 316 - - > Asn in the C - terminus of p38 , analogous to the ERK2 ( extracellular - signal - regulated kinase 2 ) sevenmaker mutation , dramatically decreases its binding to MKP - 1 and substantially compromises its stimulatory effect on the catalytic activity of this phosphatase .
Output (English): MKP - 1