Task: Question Answering
Input (English): Context: Male circumcision is the removal of the foreskin from the human penis. In the most common procedure, the foreskin is opened, adhesions are removed, and the foreskin is separated from the glans. After that, the circumcision device (if used) is placed, and then the foreskin is cut off. Topical or locally injected anesthesia is occasionally used to reduce pain and physiologic stress. For adults and children, general anesthesia is an option, and the procedure may be performed without a specialized circumcision device. The procedure is most often an elective surgery performed on babies and children for religious and cultural reasons. In other cases it may be done as a treatment for a condition or for preventative reasons. Medically, it is a treatment option for problematic cases of phimosis, balanoposthitis that does not resolve with other treatments, and chronic urinary tract infections (UTIs). It is contraindicated in cases of certain genital structure abnormalities or poor general health.
The positions of the world's major medical organizations range from considering elective circumcision of babies and children as having no benefit and significant risks to having a modest health benefit that outweighs small risks. No major medical organization recommends either universal circumcision for all males (aside from the recommendations of the World Health Organization (WHO) for areas with high rates of HIV), or banning the procedure. Ethical and legal questions regarding informed consent and human rights have been raised over the circumcision of babies and children for non-medical reasons, and for that reason the procedure is controversial.
Evidence supports that male circumcision reduces the risk of HIV infection among heterosexual men in sub-Saharan Africa. Therefore, the WHO recommends considering circumcision as part of a comprehensive HIV prevention program in areas with high rates of HIV, such as Sub Saharan Africa. Evidence for a health benefit against HIV for men who have sex with men is less clear. Additionally, the effectiveness of using circumcision to prevent HIV in the developed world is also unclear. Circumcision in general is associated with reduced rates of cancer causing forms of HPV and risk of both UTIs and cancer of the penis. Prevention of those conditions is not a justification for routine circumcision of infants. Studies of its potential protective effects against other sexually transmitted infections have been unclear. A 2010 review of literature found circumcisions performed by medical providers to have a typical complication rate of 1.5% for babies and 6% for older children, with few cases of severe complications. Bleeding, infection and the removal of either too much or too little foreskin are the most common complications cited. Complication rates are higher when the procedure is performed by an inexperienced operator, in unsterile conditions, or when the child is at an older age. Circumcision does not appear to have a negative impact on sexual function.
An estimated one-third of males worldwide are circumcised. The procedure is most common in the Muslim world and Israel (where it is near-universal for religious reasons), the United States, and parts of Southeast Asia and Africa. It is relatively rare in Europe, Latin America, parts of Southern Africa, and most of Asia. The origin of circumcision is not known with certainty; the oldest documented evidence for it comes from ancient Egypt. Various theories have been proposed as to its origin, including as a religious sacrifice and as a rite of passage marking a boy's entrance into adulthood. It is part of religious law in Judaism and is an established practice in Islam, Coptic Christianity, and the Ethiopian Orthodox Church. The word circumcision is from Latin "circumcidere", meaning "to cut around". , Heart failure (HF), often referred to as congestive heart failure (CHF), occurs when the heart is unable to pump sufficiently to maintain blood flow to meet the body's needs. Signs and symptoms commonly include shortness of breath, excessive tiredness, and leg swelling. The shortness of breath is usually worse with exercise, while lying down, and may wake the person at night. A limited ability to exercise is also a common feature. Chest pain, including angina, does not typically occur due to heart failure.
Common causes of heart failure include coronary artery disease including a previous myocardial infarction (heart attack), high blood pressure, atrial fibrillation, valvular heart disease, excess alcohol use, infection, and cardiomyopathy of an unknown cause. These cause heart failure by changing either the structure or the functioning of the heart. There are two main types of heart failure: "heart failure due to left ventricular dysfunction" and "heart failure with normal ejection fraction" depending on whether the ability of the left ventricle to contract is affected, or the heart's ability to relax. The severity of disease is usually graded by the degree of problems with exercise. Heart failure is not the same as myocardial infarction (in which part of the heart muscle dies) or cardiac arrest (in which blood flow stops altogether). Other diseases that may have symptoms similar to heart failure include obesity, kidney failure, liver problems, anemia, and thyroid disease.
The condition is diagnosed based on the history of the symptoms and a physical examination with confirmation by echocardiography. Blood tests, electrocardiography, and chest radiography may be useful to determine the underlying cause. Treatment depends on the severity and cause of the disease. In people with chronic stable mild heart failure, treatment commonly consists of lifestyle modifications such as stopping smoking, physical exercise, and dietary changes, as well as medications. In those with heart failure due to left ventricular dysfunction, angiotensin converting enzyme inhibitors or angiotensin receptor blockers along with beta blockers are recommended. For those with severe disease, aldosterone antagonists, or hydralazine with a nitrate may be used. Diuretics are useful for preventing fluid retention. Sometimes, depending on the cause, an implanted device such as a pacemaker or an implantable cardiac defibrillator may be recommended. In some moderate or severe cases cardiac resynchronization therapy (CRT) may be suggested or cardiac contractility modulation may be of benefit. A ventricular assist device or occasionally a heart transplant may be recommended in those with severe disease despite all other measures.
Heart failure is a common, costly, and potentially fatal condition. In developed countries, around 2% of adults have heart failure and in those over the age of 65, this increases to 610%. In the year after diagnosis the risk of death is about 35% after which it decreases to below 10% each year. This is similar to the risks with a number of types of cancer. In the United Kingdom the disease is the reason for 5% of emergency hospital admissions. Heart failure has been known since ancient times with the Ebers papyrus commenting on it around 1550 BCE., Coronary artery disease (CAD), also known as ischemic heart disease (IHD), is a group of diseases that includes: stable angina, unstable angina, myocardial infarction, and sudden cardiac death. It is within the group of cardiovascular diseases of which it is the most common type. A common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Occasionally it may feel like heartburn. Usually symptoms occur with exercise or emotional stress, last less than a few minutes, and get better with rest. Shortness of breath may also occur and sometimes no symptoms are present. The first sign is occasionally a heart attack. Other complications include heart failure or an irregular heartbeat., Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long term medical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms. Long term high blood pressure, however, is a major risk factor for coronary artery disease, stroke, heart failure, peripheral vascular disease, vision loss, and chronic kidney disease.
High blood pressure is classified as either primary (essential) high blood pressure or secondary high blood pressure. About 9095% of cases are primary, defined as high blood pressure due to nonspecific lifestyle and genetic factors. Lifestyle factors that increase the risk include excess salt, excess body weight, smoking, and alcohol. The remaining 510% of cases are categorized as secondary high blood pressure, defined as high blood pressure due to an identifiable cause, such as chronic kidney disease, narrowing of the kidney arteries, an endocrine disorder, or the use of birth control pills.
Blood pressure is expressed by two measurements, the systolic and diastolic pressures, which are the maximum and minimum pressures, respectively. Normal blood pressure at rest is within the range of 100140 millimeters mercury (mmHg) systolic and 6090 mmHg diastolic. High blood pressure is present if the resting blood pressure is persistently at or above 140/90 mmHg for most adults. Different numbers apply to children. Ambulatory blood pressure monitoring over a 24-hour period appears more accurate than office best blood pressure measurement.
Lifestyle changes and medications can lower blood pressure and decrease the risk of health complications. Lifestyle changes include weight loss, decreased salt intake, physical exercise, and a healthy diet. If lifestyle changes are not sufficient then blood pressure medications are used. Up to three medications can control blood pressure in 90% of people. The treatment of moderately high arterial blood pressure (defined as >160/100 mmHg) with medications is associated with an improved life expectancy. The effect of treatment of blood pressure between 140/90 mmHg and 160/100 mmHg is less clear, with some reviews finding benefit and others finding a lack of evidence for benefit. High blood pressure affects between 16 and 37% of the population globally. In 2010 hypertension was believed to have been a factor in 18% (9.4 million) deaths., Israel , officially known as the State of Israel, is a country in the Middle East, on the southeastern shore of the Mediterranean Sea and the northern shore of the Red Sea. It has land borders with Lebanon to the north, Syria to the northeast, Jordan on the east, the Palestinian territories of the West Bank and Gaza Strip to the east and west, respectively, and Egypt to the southwest. The country contains geographically diverse features within its relatively small area. Israel's financial and technology center is Tel Aviv, while its seat of government and proclaimed capital is Jerusalem, although the state's sovereignty over the city of Jerusalem is internationally unrecognized., The terms Muslim world and Islamic world commonly refer to the Islamic community (Ummah), comprising all those who adhere to the religion of Islam, or to societies where Islam is practiced. In a modern geopolitical sense, these terms refer to countries where Islam is widespread, although there are no agreed criteria for inclusion., The World Health Organization (WHO) is a specialized agency of the United Nations that is concerned with international public health. It was established on 7 April 1948, headquartered in Geneva, Switzerland. The WHO is a member of the United Nations Development Group. Its predecessor, the Health Organization, was an agency of the League of Nations., Stroke is when poor blood flow to the brain results in cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. They result in part of the brain not functioning properly. Signs and symptoms of a stroke may include an inability to move or feel on one side of the body, problems understanding or speaking, feeling like the world is spinning, or loss of vision to one side. Signs and symptoms often appear soon after the stroke has occurred. If symptoms last less than one or two hours it is known as a transient ischemic attack (TIA) or mini-stroke. A hemorrhagic stroke may also be associated with a severe headache. The symptoms of a stroke can be permanent. Long-term complications may include pneumonia or loss of bladder control.
The main risk factor for stroke is high blood pressure. Other risk factors include tobacco smoking, obesity, high blood cholesterol, diabetes mellitus, previous TIA, and atrial fibrillation. An ischemic stroke is typically caused by blockage of a blood vessel, though there are also less common causes. A hemorrhagic stroke is caused by either bleeding directly into the brain or into the space between the brain's membranes. Bleeding may occur due to a ruptured brain aneurysm. Diagnosis is typically with medical imaging such as a CT scan or magnetic resonance imaging (MRI) scan along with a physical exam. Other tests such as an electrocardiogram (ECG) and blood tests are done to determine risk factors and rule out other possible causes. Low blood sugar may cause similar symptoms.
Prevention includes decreasing risk factors, as well as possibly aspirin, statins, surgery to open up the arteries to the brain in those with problematic narrowing, and warfarin in those with atrial fibrillation. A stroke or TIA often requires emergency care. An ischemic stroke, if detected within three to four and half hours, may be treatable with a medication that can break down the clot. Aspirin should be used. Some hemorrhagic strokes benefit from surgery. Treatment to try recover lost function is called stroke rehabilitation and ideally takes place in a stroke unit; however, these are not available in much of the world.
In 2013 approximately 6.9 million people had an ischemic stroke and 3.4 million people had a hemorrhagic stroke. In 2010 there were about 33 million people who had previously had a stroke and were still alive. Between 1990 and 2010 the number of strokes which occurred each year decreased by approximately 10% in the developed world and increased by 10% in the developing world. In 2013, stroke was the second most frequent cause of death after coronary artery disease, accounting for 6.4 million deaths (12% of the total). About 3.3 million deaths resulted from ischemic stroke while 3.2 million deaths resulted from hemorrhagic stroke. About half of people who have had a stroke live less than one year. Overall, two thirds of strokes occurred in those over 65 years old., Informed consent is a process for getting permission before conducting a healthcare intervention on a person. A health care provider may ask a patient to consent to receive therapy before providing it, or a clinical researcher may ask a research participant before enrolling that person into a clinical trial. Informed consent is collected according to guidelines from the fields of medical ethics and research ethics., Islam (' ;) is a religion articulated by the Quran, a text considered by its adherents to be the verbatim word of God ('), and, for the vast majority of adherents, the teachings and normative example (called the "sunnah", composed of accounts called "hadith") of Muhammad (5708 June 632 CE). It is the world's second-largest religion and the fastest-growing major religion in the world, with over 1.7 billion followers or 23% of the global population, known as Muslims. Islam is an Abrahamic monotheistic religion that upholds that God is one and incomparable and that the purpose of existence is to worship God. Muslims consider Muhammad to be the last prophet of God., Judaism (from , derived from Greek , originally from Hebrew , "Yehudah", "Judah"; in Hebrew: , "Yahadut", the distinctive characteristics of the Judean ethnos) encompasses the religion, philosophy, culture and way of life of the Jewish people. Judaism is an ancient monotheistic religion, with the Torah as its foundational text (part of the larger text known as the Tanakh or Hebrew Bible), and supplemental oral tradition represented by later texts such as the Midrash and the Talmud. Judaism is considered by religious Jews to be the expression of the covenantal relationship that God established with the Children of Israel. With between 14.5 and 17.4 million adherents worldwide, Judaism is the tenth-largest religion in the world., A Muslim is someone who follows or practises Islam, a monotheistic Abrahamic religion. Muslims consider the Quran (Koran), their holy book, to be the verbatim word of God as revealed to the Islamic prophet and messenger Muhammad. They also follow the teachings and practices of Muhammad ("sunnah ") as recorded in traditional accounts ("hadith"). "Muslim" is an Arabic word meaning "one who submits (to God)"., The pope (from "pappas", a child's word for "father") is the Bishop of Rome and, therefore, the leader of the worldwide Catholic Church. The primacy of the Roman bishop is largely derived from his role as the traditional successor to Saint Peter, to whom Jesus is supposed to have given the keys of Heaven and the powers of "binding and loosing", naming him as the "rock" upon which the church would be built. The current pope is Francis, who was elected on 13 March 2013, succeeding Benedict XVI., A biomolecule or biological molecule is molecule that is present in living organisms, including large macromolecules such as proteins, carbohydrates, lipids, and nucleic acids, as well as small molecules such as primary metabolites, secondary metabolites, and natural products. A more general name for this class of material is biological materials. Biomolecules are usually endogenous but may also be exogenous. For example, pharmaceutical drugs may be natural products or semisynthetic (biopharmaceuticals) or they may be totally synthetic., William Thomas Astbury FRS (also Bill Astbury; 25 February 1898, Longton  4 June 1961, Leeds) was an English physicist and molecular biologist who made pioneering X-ray diffraction studies of biological molecules. His work on keratin provided the foundation for Linus Pauling's discovery of the alpha helix. He also studied the structure for DNA in 1937 and made the first step in the elucidation of its structure., A president is the leader of a country or a division or part of a country, typically a republic, a democracy, or a dictatorship. The title "president" is sometimes used by extension for leaders of other groups, including corporate entities and social groups., Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes. RNA and DNA are nucleic acids, and, along with proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life. Like DNA, RNA is assembled as a chain of nucleotides, but unlike DNA it is more often found in nature as a single-strand folded onto itself, rather than a paired double-strand. Cellular organisms use messenger RNA (mRNA) to convey genetic information (using the letters G, U, A, and C to denote the nitrogenous bases guanine, uracil, adenine, and cytosine) that directs synthesis of specific proteins. Many viruses encode their genetic information using an RNA genome., The University of Sydney (informally, USyd) is an Australian public research university in Sydney, Australia. Founded in 1850, it is Australia's first university and is regarded as one of the country's leading universities. The university comprises 16 faculties and schools, through which it offers bachelor, master and doctoral degrees. In 2011 it had 32,393 undergraduate and 16,627 graduate students., A prime minister is the most senior minister of cabinet in the executive branch of government, often in a parliamentary or semi-presidential system. In many systems, the prime minister selects and may dismiss other members of the cabinet, and allocates posts to members within the government. In most systems, the prime minister is the presiding member and chairman of the cabinet. In a minority of systems, notably in semi-presidential systems of government, a prime minister is the official who is appointed to manage the civil service and execute the directives of the head of state.
In parliamentary systems fashioned after the Westminster system, the prime minister is the presiding and actual head of government and head of the executive branch. In such systems, the head of state or the head of state's official representative (i.e. the monarch, president, or governor-general) usually holds a largely ceremonial position, although often with reserve powers., Molecular biology concerns the molecular basis of biological activity between biomolecules in the various systems of a cell, including the interactions between DNA, RNA, and proteins and their biosynthesis, as well as the regulation of these interactions. Writing in "Nature" in 1961, William Astbury described molecular biology as:, Emeritus, in its current usage, is an adjective used to designate a retired professor, pastor, bishop, pope, president, prime minister, or other person., Professor (commonly abbreviated as "prof.") is an academic rank at universities and other post-secondary education and research institutions in most countries. Literally, "professor" derives from Latin as a "person who professes" being usually an expert in arts or sciences, a teacher of the highest rank., A rite of passage is a celebration of the passage which occurs when an individual leaves one group to enter another. It involves a significant change of status in society. In cultural anthropology the term is the Anglicisation of "rite de passage", a French term innovated by the ethnographer Arnold van Gennep in his work "Les rites de passage", "The Rites of Passage." The term is now fully adopted into anthropology as well as into the literature and popular cultures of many modern languages., Deoxyribonucleic acid (DNA) is a molecule that carries the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses. DNA and RNA are nucleic acids; alongside proteins, lipids and complex carbohydrates (polysaccharides), they are one of the four major types of macromolecules that are essential for all known forms of life. Most DNA molecules consist of two biopolymer strands coiled around each other to form a double helix., Brian James Morris ( born 14 July 1950 ) is a professor emeritus of molecular medical sciences at the University of Sydney , Australia . His research has mainly been in the field of molecular biology and molecular genetics , with a particular interest in hypertension . He is a long time circumcision advocate , and has written a pro-circumcision book and runs a pro-circumcision website ., Subject: brian morris , Relation: occupation, Options: (A) academic (B) accounting (C) bank (D) bishop (E) conducting (F) emeritus (G) ethnographer (H) father (I) general (J) governor (K) human rights (L) islam (M) leader (N) major (O) member (P) minister (Q) molecular biologist (R) monarch (S) official (T) physicist (U) president (V) prime minister (W) professor (X) prophet (Y) religion (Z) religious ([) research (\) travel (]) united kingdom
Output (English): molecular biologist