Task: Question Generation
Input (English): A pedigree is a chart that shows the inheritance of a trait over several generations. A pedigree is commonly created for families, and it outlines the inheritance patterns of genetic disorders and traits. A pedigree can help predict the probability that offspring will inherit a genetic disorder. Pictured below is a pedigree displaying recessive inheritance of a disorder through three generations ( Figure 1.1). From studying a pedigree, scientists can determine the following: If the trait is sex-linked (on the X or Y chromosome) or autosomal (on a chromosome that does not determine sex). If the trait is inherited in a dominant or recessive fashion. Sometimes pedigrees can also help determine whether individuals with the trait are heterozygous (two different alleles) or homozygous (two of the same allele). Some points to keep in mind when analyzing a pedigree are: 1. With autosomal recessive inheritance, all affected individuals will be homozygous recessive. 2. With dominant inheritance, all affected individuals will have at least one dominant allele. They will be either homozygous dominant or heterozygous. 3. With sex-linked inheritance, more males (XY) than females (XX) usually have the trait. Sex-linked inheritance is usually recessive.
Output (English): in autosomal recessive inheritance, all affected individuals