Task: Sentence Composition
Input (English): Costs are not discussed, as this is an investigational procedure. The article provides n values and quantifies the results from the first stage of the study. The potential benefits of the test have to do with its ability to rule out malignancy based on X-ray results; thus, the specificity and sensitivity data are particularly relevant. We wish the paragraph on subjects with stage I disease would have quantified the results. It provides no sensitivity or specificity rates to justify the conclusion of the technique’s potential application in early stage disease. Quantified harms are not as pertinent since this a blood test. However, one could infer indirect harms, the false positives and false negatives, from the data provided. The story is up-front about these results being preliminary and from a conference. Ideally, the story should have further described the preliminary nature of these findings, in a way that would have made sense to a lay audience. The results have not been peer-reviewed, and the technique is only being developed based on these data. In other words, the study didn’t assess a technique, they built one to match the data. The strategy hasn’t been tested in a realistic population.As this report was all about a new diagnostic test, is it particularly important to define the groups clearly and the sensitivity/ specificity (and positive predictive value/ negative predictive value). This is where independent expert assessment of these results would have helped clarify their significance and early status. Regarding SomaDX, mentioned offhand, this evidence and its 90% sensitivity isn’t evaluated at all. At the time of this article, the report hadn’t even been officially released by the company, and not independently vetted. The article does not exaggerate the burden of lung cancer, accurately citing ACS statistics and the enormous importance of the disease. It also does not overstate the problem of false positives. An independent source was cited, a meeting attendant, and the SomaLogic quotes were added for context. The latter were good for illustrating that the Dubinett group is not the only game in town working on this type of blood test. Ideally, the article would have had more independent analysis of the specific results. No independent source was used to assess the SomaLogic employee’s claims of their experimental test’s sensitivity. Although the MedPage Today coverage of the study is aimed at a professional medical audience, it provides a good example of some of the critical points outside sources can provide about these type of very early results. Although the article does not identify conflicts of interest, from the MedPage Today article it’s not clear that the investigators disclosed any conflicts of interest in their abstract.
Output (English): Blood Test for Lung Cancer in the Works