Task: Sentence Composition
Input (English): The story mentioned that it was expected that the drug reported on would cost $8/day as compared with <$1/day for warfarin. One aspect of costs that were not considered in this story is the difference in monitoring, which would be less with patients using Eliquis. The competing HealthDay story did a better job on this latter point. The story provided only relative risk reduction figures – “prevented 21 percent more strokes…31 percent fewer incidents of major bleeding…reduced total deaths by 11 percent” – but neglected to present the absolute decrease in adverse events. 21% of what? 31% of what? 11% of what? The story mentioned some of the disadvantages associated with this use of the medication reported on. It did not specifically detail whether there were any harms associated with this medication or how well people in the study were able to stick with the dosing schedule. On this issue, this story was not as complete as its HealthDay competition, which reported: “The new trial comes on the heels of another study on apixaban that was stopped early due to safety concerns. In that trial, published in July in the New England Journal of Medicine, apixaban’s use was associated with raised odds for bleeding — without providing patients with any reduction in heart attack risk.However, “in that case, apixaban was given to patients with coronary artery disease who were also taking two other blood thinners,” Ansell noted. “The three of them together showed that the risk of bleeding was just too high and there was no real benefit in that population. But, that’s an entirely different problem, compared with atrial fibrillation,” he said.” The story included a lot of information about the study it reported on – where the results were presented and published, its design, the number of clinical sites, countries involved, the number of people studied and the length of time they were studied.. No overt disease mongering. The story mentioned that the study reported on had been funded by the drug maker. It included comments from a clinician who had no ties to the study reported on. The story compared the study drug with the long time treatment, warfarin, as well as mentioning a newly approved medication and another medication in the approval process. The story opened by indicating that Eliquis (apixabane) was experimental and closed by indicating the expectation of submission to the FDA for approval. The story was clear that this was a new medication, though there are two other medications (warfarin and Pradax) that are currently available. Did not appear to rely solely on a news release.
Output (English): Trial Shows Blockbuster Potential for Blood Clot Pill