Task: Sentence Composition
Input (English): The cost of the drug is not particularly relevant in this case. This story points out the potential benefits of Dimebon based upon preliminary research, but didn’t quantify those benefits. These include improved cognition, memory and ability to perform activities of daily living. These potential benefits should have been placed in the context of existing medications which have shown a very modest effect in these outcomes, in only one-third of people, and for a short-period of time. Little is know about the long-term use of these medications. The story references general concerns of experimental drugs which do not have proven effectiveness or safety. Potential harms of Dimebon were not mentioned. However, the research study about the Dimebon published in The Lancet reported that dry mouth was the most common side effect. For reference, there can be gastrointestinal side effects from currently approved medications. These are usually dose related and can be minimised by taking the medications with food and gradually increasing the dose overtime. This story takes a point-by-point approach to evaluate the medical issues related to Alzheimer’s disease raised in the TV episode. The Premise section provides a good, basic description of PET scan brain imaging and symptoms of mild to moderate memory loss. The story should have clearly noted that PET scans do not provide a definitive diagnosis and that tests to evaluate memory such as questionnaires and neurological examinations, are routinely performed as the first line of evaluation. The piece does provide an appropriate level of depth in its discussion of the experimental nature of Dimebon, results of research conducted in Russia, and the stages of the FDA approval process. Basics facts about the prevalence of Alzheimer’s disease were not provided, but would have helped readers to understand how many people are affected (about 15% over 70 years old). Given that, Alzheimer’s disease was accurately characterized in the story. The story includes interviews from an independent medical expert and the chief medical officer for the Alzheimer’s Association (www.alz.org). This story could have been enhanced by adding that there are currently no cures for Alzheimer’s disease. It should have noted that available medications can help a small number of people but only for a limited amount of time. This story clearly indicates that the experimental drug Dimebon is not available in the U.S. It also notes that the drug won’t be available for at least three years, pending FDA approval. The story indicates that Dimebon is a new and experimental drug to treat Alzheimer’s disease. This story does not rely on a press release.
Output (English): ‘Boston Legal’ lawyer makes his case for Alzheimer’s drug