Task: Sentence Composition
Input (English): The article includes price information for the drug’s likely competitor, Plavix–about $4 per day, a significant cost for a drug that is taken daily, perhaps for a lifetime. The article correctly indicates that the price of Plavix is likely to come down when it goes generic in four years. The article properly includes speculation that the pricing of prasugrel may be a key factor in its adoption, should it be approved. The reporter includes considerable data about several key clinical endpoints of both benefits and harms, in two cases using both absolute numbers of patients and percentage increase or descrease. The reporter gets extra points for including "number needed to treat"–the number of people who would have  clinically significant outcomes for each 1,000 treated with the drug. The story is built around the question of the drugs’ risks vs. benefits. Data about harms are mentioned early and often, and described in detail. A direct comparision of the fatal bleeding rates for the two drugs would have been additionally useful. The New England Journal of Medicine article is based on results of a Phase III trial that appears to meet all the important criteria for significance: the study is prospective, the study group is large, the patients were randomized, the treatments double-blinded, the clinical endpoints signficant. While there is no placebo group, this was likely decided for ethical reasons, so all patients in the study would receive at least current best-practice treatment. The article assigns proper crediblity to the study, which to appear in NEJM has received rigorous peer review. The article does nothing to exaggerate the risk of death or the consequences of heart attacks, strokes or cardiovascular disease deaths. It allows the outcome figures to speak for themselves. The article quotes five experts in cardiology from different institutions, providing greater balance and context than just one or two experts would. In each case the relationship of the souce to the study and/or its funders is revealed. The considerable conflicts of interest of the investigators are made very clear. The article makes clear that prasugrel is being developed as an option to Plavix, and that Plavix with aspirin is currently best-practice treatment. The article makes clear that the drug prasugrel is not FDA approved and that its approval is uncertain. The article makes clear that this is a drug that is very similar to Plavix, and that it may be marginally more effective. No claims of novelty are made. The companies’ joint press release, an enthusiastic announcement about the drug’s benefits, bears little resemblance to this story.
Output (English): Blood drug trades benefit for risk