Task: Text Categorization
Input (English): Question: Acetylation of histones affects transcription: 
 Options:  <0> Blocking the incorporation of other components of the transcription machinery. <1> Preventing the remodeling of chromatin. <2> Facilitating the action of helicases. <3> Decreasing sensitivity to nuclear receptors. <4> Reducing the affinity of histones for DNA.
Output (English): chemistry