Task: Translation
Input (Czech): eÜen  se t²k  zp sobu v²roby pelet, obsahuj c ch .>=. 50 % hmotnostn ch farmaceutick  · inn  l tky s rozpustnost  ve vod  .>=. 0,5 g/ml granulac  sm si obsahuj c  · innou l tku s vodou, extruz , zaoblov n m a suÜen m vlhk²ch pelet, p°i em  · innou l tku obsahuj c  sm s sest v  z alespo  50 % hmotnostn ch alespo  jedn  · inn  l tky s rozpustnost  ve vod  .>=. 0,5 g/ml a nejv²Üe 50 % hmotnostn ch kombinace a) z mikrokrystalick  celul zy se st°edn  velikost    stic 15 a  25 .mi.m a b) n zko substituovan  hydroxypropylcelul zy se st°edn  velikost    stic v rozmez  10 a  25 .mi.m, p°i em  hmotnostn  pom t a) : b) je v rozmez  4 : 6 a  6 : 4 a do sm si se zapracuje pouze tolik vody,  e tato m  dostate nou plasticitu pro extrudov n  a sf ronizaci.\
Output (English): The present invention relates to a process for preparing pellets containing 50 or more percent by weight of a pharmaceutically active substance with water solubility equal to or greater than 0.5 g/ml by granulation of a mixture containing the active substance and water, followed by extrusion, rounding off and drying of wet pellets, whereby the active substance contained in the mixture consists of at least 50 percent by weight of at least one active substance exhibiting water solubility equal to or greater than 0.5 g/ml and at the most 50 percent by weight of a combination of a) microcrystalline cellulose having average particle size 15 to 25 microns and b) low-substituted hydroxypropyl cellulose with average particle size within the range of 10 to 25 microns, whereby the weight ratio of a) : b) is in the range of 4 : 6 to 6 : 4 and water is added to the mixture in such an amount causing sufficient plasticity of the mixture for extrusion and spheroizing.