Task: Translation
Input (Czech): Deriváty 2-fenyl-3-hydroxychinolin-4(1H)-onu obecného vzorce II a III, kde X predstavuje nitroskupinu, aminoskupinu a Y predstavuje atom halogenu, kyslíku nebo síry substituovaný C.sub.1.n. až C.sub.6.n. alkylem nebo fenylovou skupinou, pricemž jak alkylová, tak fenylová skupina muže být dále substituována, kde substituenty mohou být stejné nebo odlišné, nebo dusíku substituovaným nezávisle vodíkem, C.sub.1.n. až C.sub.6.n. alkylem, C.sub.1.n. až C.sub.6.n. alkylem, který muže být substituován mimo jiné halogenem, hydroxy, C.sub.1.n. až C.sub.4.n. alkoxy nebo C.sub.1.n. až C.sub.4.n. alkylamino skupinou, nebo mohou tvorit nasycený nebo nenasycený heterocyklický kruh o poctu atomu 5 až 7, pricemž jednotlivé atomy kruhu jsou tvoreny atomy uhlíku, pricemž kterýkoli atom uhlíku muže být nahrazen atomem dusíku, síry nebo kyslíku, X a Y dohromady tvorí imidazoskupinu, nebo imidazoskupinu substituovanou C.sub.1.n. až C.sub.6.n. alkylem, který muže být substituován mimo jiné halogenem, hydroxy, C.sub.1.n. až C.sub.4.n. alkoxy nebo C.sub.1.n. až C.sub.4.n. alkylamino skupinou, CHO nebo acetylskupinou, nebo heterocyklický kruh o poctu atomu 5 až 6, pricemž atomy kruhu mohou být dále substituovány. Jsou popsány zpusoby prípravy techto sloucenin. Dále je popsána jejich cytostatická, cytotoxická, antiproliferacní a imunosupresivní aktivita s príklady jejich možného farmakologického a farmaceutického použití.
Output (English): In the present invention, there are disclosed 2-phenyl-3-hydroxyquinoline-4(1H)-one derivatives of the general formulae II and III, where X represents a nitro group, an amino group, and Y represents a halogen atom, an oxygen atom or a sulfur atom substituted with alkyl containing 1 to 6 carbon atoms or with a phenyl group, whereby both the alkyl and phenyl group may be further substituted and the substituents may be identical or different, or by nitrogen substituted independently by hydrogen, C1 to C6 alkyl having 1 to 6 carbon atoms, which may be substituted among others by halogen, hydroxy, alkoxy containing 1 to 4 carbon atoms or by an alkylamino group having 1 to 4 carbon atoms, or may form a saturated or unsaturated heterocyclic ring with 5 to 7 atoms, wherein the individual ring atoms comprise atoms of carbon, and any of the carbon atoms may be substituted by an atom of nitrogen, sulfur or oxygen, X and Y together form an imidazo group, or imidazo group substituted with alkyl containing 1 to 6 carbon atoms,; which may be substituted among others with halogen, hydroxy, alkoxy having 1 to 4 carbon atoms or with an alkylamino group containing 1 to 4 carbon atoms, CHO or an acetyl group, or a heterocyclic ring with 5 to 6 atoms, where the ring atoms may be further substituted. There are also described processes for preparing the above-described compounds. In addition, there is further described their cytostatic, cytotoxic, antiproliferative and immunosuppressive activity as well as examples of their potential pharmacological and pharmaceutical use.