Task: Translation
Input (Czech): Analog vitaminu D obecného vzorce I, kde X je H nebo OH; R.sup.1.n. a R.sup.2.n. je H nebo alkyl s 1 az 3 C atomy nebo R.sup.1.n. a R.sup.2.n. spolecne s C atomem nesoucím skupinu X tvorí karbocyklický kruh obsahující 3 az 6 C atomu; R.sup.3.n. je alkyl s 1 az 3 C atomy, aryl nebo aralkyl nebo YR.sup.4.n., kde Y je -CO-S-, -CS-O- nebo -CS-S-; R.sup.4.n. je alkyl s 1 az 3 C atomy, aryl nebo aralkyl; Q je (CH.sub.2.n.).sub.n.n., kde n je 1 az 4; pricemz R.sup.1.n., R.sup.2.n. a Q mohou být navíc nezávisle substituovány jedním nebo více F atomy; zpusob jeho výroby a pouzití pro výrobu léciva. Farmaceutická kompozice s jeho obsahem pro pouzití pro lécení a/nebo profylaxi chorobných stavu, pro nez je charakteristická abnormální bunecná deferenciace a/nebo bunecná proliferace, chorob nebo nevyvázenosti imunitního systému a zánetlivých onemocnení a jiných chorob.
Output (English): In the present invention, there is disclosed vitamin D analogue of the general formula I, in which X represents hydrogen or OH; Re1 and Re2 represent hydrogen or alkyl having 1 to 3 carbon atoms or Re1 and Re2 taken together with the carbon atom bearing the group X, can form a carbocyclic ring containing 3 to 6 carbon atoms; Re3 denotes alkyl having 1 to 3 carbon atoms, aryl or aralkyl or YRe4, wherein Y represents -CO-S-, -CS-O- or -CS-S-; Re4 denotes alkyl with 1 to 3 carbon atoms, aryl or aralkyl; Q represents (CHi2)in, wherein n is 1 to 4; wherein Re1, Re2 and Q independently may optionally be substituted with one or more fluorine atoms; process for its preparation and use for preparing a medicament. Disclosed is also a pharmaceutical composition in which the analogue is comprised and intended for use in treatment and/or prophylaxis of disease states being characterized by abnormal cell differentiation and/or cell proliferation, further diseases or unbalance of immune system and inflammatory diseases and other disorders.