Task: Text Categorization
Input (English): One gene which is commonly implicated in the early-onset form of this disease forms a complex with Nicastrin, Aph-I and Pen-2 called the Gamma Secretase complex. In addition to the PS1 and PS2 proteins, an aspartyl protease implicated in this disease called BACE. BACE, along with the similarly named TACE are potential drug targets for slowing the progression of this disease. Treatments for it include the NMDA receptor antagonist called memantine, and cholinesterase inhibitors. A 40-peptide fragment central to this disease has E22Q and E22G mutations called the Arctic and Dutch variants, and those fragments of the APP protein form plaques which accumulate in the cerebral cortex, along with fibrillary tangles of the Tau protein. Beta-amyloid plaques occur in, for 10 points, which neurodegenerative disease named for a German neurologist
Output (English): Science