Task: Translation
Input (Czech): Deriv ty 5-substituovan²ch pyrrolo[3,4-d]pyrimidin-2,4-dion  obecn ho vzorce I, kde substituenty maj  specifick² v²znam, zp sob jejich p° pravy, farmaceutick  prost°edky, kter  je obsahuj  a pou it  t chto deriv t  pro l  bu nebo prevenci revmatoidn  artritidy nebo rezistence k transplantovan²m org n m nebo tk n m.\
Output (English): In the present invention there are disclosed derivatives of 5-substituted pyrrolo[3,4-d]pyrimidine-2,4-diones of the general formula I, in which the  substituents have specific meaning, further process of their preparation, pharmaceuticals in which the derivatives are comprised as well as the use of these derivatives for treating or prevention of rheumatic arthritis or resistance to transplanted organs or tissues.