Task: Translation
Input (Czech): Tkánove selektivní estrogeny vzorce I, kde R.sub.1.n. a R.sub.2.n. jsou nezávisle vodíkový atom, alkyl o 1 až 6 atomech uhlíku, benzyl, acyl o 2 až 7atomech uhlíku, benzoyl, (1) nebo (2); X je vodík, alkyl o 1 až 6 atomech uhlíku, CN, halogen, trifluormethyl nebo thioalkyl o 1 až 6 atomech uhlíku;n je 1 až 3; s výhradou, že alespon 1 ze substituentu R.sub.1.n. a R.sub.2.n. je (1) nebo (2). Slouceniny jsou vhodné k lécbe stavu jako je úbytek kostí, osteoporéza, osteoarthritida, hypokalcinémie,Pagetova nemoc, meknutí kostí, osteokalisteréza amnohocetný myelom. Slouceniny jsou též vhodné k antiestrogenové lécbe.
Output (English): Tissue selective estrogens of formula I wherein R 1 is 1. and R.sub.2.n. are independently hydrogen, alkyl of 1 to 6 carbon atoms, benzyl, acyl of 2 to 7 carbon atoms, benzoyl, (1) or (2); X is hydrogen, alkyl of 1 to 6 carbon atoms, CN, halogen, trifluoromethyl or thioalkyl of 1-6 carbon atoms, n is 1-3; with the proviso that at least 1 of the substituent R.sub.1.n. and R.sub.2.n. is (1) or (2). The compounds are useful in the treatment of conditions such as bone loss, osteoporosis, osteoarthritis, hypocalcaemia, Paget's disease, bone softening, osteocalisteresis and multiple myeloma. The compounds are also suitable for antiestrogen therapy.