Task: Translation
Input (Spanish): Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.
Output (English): Tambien se describen metodos para elaborar los compuestos, y su uso como agentes terapeuticos, por ejemplo, en el tratamiento de cancer y otras enfermedades caracterizadas por defectos en la replicacion del ADN, segregacion cromosomica, o division celular.