Task: Translation
Input (Czech): Deriváty linkomycinu jsou pripravovány biotechnologickou kultivací Streptomyces lincolnensis ATCC 25466, který má inaktivovaný gen lmbJ a/nebo alespon jeden gen ze skupiny genu lmb tvorené geny lmbA, B1, B2, W, X a Y kódujícími biosyntézu 4-L-propylprolinu. V prípade zablokování biosyntézy 4-L-propylprolinu musí být do kultivacního média dodávána náhrada za tento meziprodukt. Biosyntézou tak vznikají nové, biologicky úcinné deriváty linkomycinu.
Output (English): The present invention relates to a preparation process of lincomycin derivatives, which are prepared by biotechnological culturing of Streptomyces lincolnensis ATCC 25466 strain having an inactivated gene from lmbJ and/or at least one gene being selected from the group of 1mb genes consisting lmbA, B1, B2, W, X and Y genes encoding biosynthesis of 4-L-propylproline. In case of inhibition of the 4-L-propylproline biosynthesis, a substitution of this intermediate must be added in the culture medium. In such a manner, due to biosynthesis, novel, biologically active lincomycin derivatives are obtained.