Task: Text Categorization
Input (English): One disorder involving this organelle is caused by a mutation in E325K on the NAGA gene, called Schindler disease. One method of transporting molecules to it involves an hsc70-containing chaperone complex. Another disorder results in enzyme transport to the extracellular space rather than this organelle and is called I-cell disease. Proteins are marked for this structure with mannose-6-phosphate, and proton pump activity in this organelle maintains the acidic pH necessary for its primary function. One genetic defect results in ganglioside buildup in this organelle and thus causes Tay-Sachs disease. For 10 points, identify this cellular organelle that breaks down macromolecules with the aid of acid hydrolases.
Output (English): Science