Task: Question Answering
Input (English): Context: Does high mobility group box protein 1 (HMGB1) regulate inflammatory reactions in a rat model of experimental autoimmune orchitis (EAO)?\Question: Does targeting high mobility group box protein 1 ameliorate testicular inflammation in experimental autoimmune orchitis?
Output (English): HMGB1 appears to be involved in regulating inflammatory reactions in testes, as HMGB1 is translocated from testicular cells during the course of EAO and blocking its action by ethyl pyruvate (EP) reduces disease progression and spermatogenic damage.