Task: Question Generation
Input (English): Context: Proton pump inhibitors (PPI) are effective at healing artificial ulcers after endoscopic submucosal dissection (ESD) for gastric neoplasms; however, the efficacy of vonoprazan is not completely understood. The aim of the present study was to determine the healing effect of vonoprazan on artificial ulcers post-gastric ESD relative to PPI.', 'Thirty-five patients who underwent gastric ESD between April and November 2015 were treated with vonoprazan 20\xa0mg/day for 4\xa0weeks and subsequently underwent endoscopy for evaluation of ulcer size (V group). Ulcer contraction rate was determined by the following formula: ([ESD specimen size]\xa0-\xa0[ulcer size at 4\xa0weeks after ESD])/(ESD specimen size)\xa0×\xa0100%. We compared the results with those of a historical control group treated with esomeprazole 20\xa0mg/day for 4\xa0weeks after gastric ESD and subsequently measured their ulcer size (33 patients, E group) by propensity score-matching methods.', "Sixty-two subjects were enrolled after propensity score-matching. Ulcer contraction rate at 4\xa0weeks after ESD in the V group was significantly higher than that of the E group (97.7\xa0±\xa03.2% vs 94.5\xa0±\xa06.7%, respectively, P\xa0=\xa00.025). Number of subjects with a scar-stage ulcer (100% contraction rate) tended to be higher in the V group relative to the E group (32% [10 of 31] vs 13% [4 of 31], respectively, P\xa0=\xa00.070, McNemar's chi-squared test).
Answer: Vonoprazan has a faster post-gastric ESD artificial ulcer contraction rate than esomeprazole. Vonoprazan may supersede PPI in treating post-ESD artificial ulcers of the stomach.
Output (English): Is vonoprazan superior to proton pump inhibitors in healing artificial ulcers of the stomach post-endoscopic submucosal dissection : A propensity score-matching analysis?