Task: Question Generation
Input (English): Context: Previous studies have suggested that DNA methylation contributes to coronary artery disease (CAD) risk variability. DNA hypermethylation at the ATP-binding cassette transporter A1 (ABCA1) gene, an important modulator of high-density lipoprotein cholesterol and reverse cholesterol transport, has been previously associated with plasma lipid levels, aging and CAD, but the association with CAD has yet to be replicated.', 'ABCA1 DNA methylation levels were measured in leucocytes of 88 men using bis-pyrosequencing. We first showed that DNA methylation at the ABCA1 gene promoter locus is associated with aging and CAD occurrence in men (P\u2009<\u20090.05). The latter association is stronger among older men with CAD (≥61\xa0years old; n\u2009=\u200919), who showed at least 4.7% higher ABCA1 DNA methylation levels as compared to younger men with CAD (<61\xa0years old; n\u2009=\u200919) or men without CAD (n\u2009=\u200950; P\u2009<\u20090.001). Higher ABCA1 DNA methylation levels in older men were also associated with higher total cholesterol (r\u2009=\u20090.34, P\u2009=\u20090.03), low-density lipoprotein cholesterol (r\u2009=\u20090.32, P\u2009=\u20090.04) and triglyceride levels (r\u2009=\u20090.26, P\u2009=\u20090.09). Furthermore, we showed that acetylsalicylic acid therapy is associated with 3.6% lower ABCA1 DNA methylation levels (P\u2009=\u20090.006), independent of aging and CAD status of patients.
Answer: This study provides new evidence that the ABCA1 epigenetic profile is associated with CAD and aging, and highlights that epigenetic modifications might be a significant molecular mechanism involved in the pathophysiological processes associated with CAD. Acetylsalicylic acid treatment for CAD prevention might involve epigenetic mechanisms.
Output (English): Are acetylsalicylic acid , aging and coronary artery disease associated with ABCA1 DNA methylation in men?