Task: Question Generation
Input (English): Context: Visit-to-visit variability in low-density lipoprotein-cholesterol (LDL-C) was found to be a novel predictor of adverse cardiac events. Obstructive sleep apnea (OSA), an emerging cardiovascular risk factor, is characterized by sympathetic activation and increased oxidative stress which are regulators of LDL-C metabolism. We hypothesized that OSA was associated with LDL-C variability.', 'We prospectively recruited 190 patients with coronary artery disease for an overnight sleep study. Statin was prescribed upon discharge for 186 patients. Serum LDL-C levels were measured at clinic every 3 to 6\xa0months. Severity of OSA (on the basis of apnea-hypopnea index (AHI)) was correlated with visit-to-visit LDL-C variability (on the basis of variation independent of mean (VIM)) in outpatient clinic.', "The mean AHI was 21.9\u2009±\u200918.9. Using an AHI cut-off of 5-14.9, 15-29.9, and ≥30, the prevalence of mild, moderate, and severe OSA was 26.3, 18.9, and 27.4\xa0%, respectively. After 53.2\u2009±\u200925.3\xa0months, LDL-C was recorded over 8.1\u2009±\u20094.2 measurements. VIM positively correlated with AHI (Pearson's r\u2009=\u20090.183, p\u2009=\u20090.016), but not body mass index, baseline and mean follow-up LDL-C levels, and number of LDL-C measurements. In multiple linear regression analysis, AHI remained an independent predictor of VIM after adjusting for diabetes mellitus and hyperlipidemia. A 10-unit rise in AHI led to a 3.8\xa0% increase in VIM (95\xa0% CI 0.1 to 7.4\xa0%; p\u2009=\u20090.044).
Answer: This is the first study to show the independent correlation between OSA severity and visit-to-visit LDL-C variability. Our finding contributes to the understanding of the vasculopathic effects of OSA.
Output (English): Is obstructive sleep apnea associated with visit-to-visit variability in low-density lipoprotein-cholesterol in patients with coronary artery disease?