Task: Question Generation
Input (English): Context: Recent studies have demonstrated that the neural precursor cell expressed, developmentally downregulated 4-like (Nedd4L) gene plays a role in the progression of various cancers. However, reports describing Nedd4L expression in ovarian cancer tissues are limited.', 'A cohort (n\u2009=\u2009117) of archival formalin-fixed, paraffin embedded resected normal ovarian epithelial tissues (n\u2009=\u200910), benign ovarian epithelial tumor tissues (n\u2009=\u200910), serous borderline ovarian epithelial tumor tissues (n\u2009=\u200914), mucous borderline ovarian epithelial tumor tissues (n\u2009=\u200911), and invasive ovarian epithelial cancer tissues (n\u2009=\u200972) were assessed for Nedd4L protein expression using immunohistochemistry.', 'Nedd4L protein expression was significantly decreased in invasive ovarian epithelial cancer tissues compared to non-cancer tissues (P\u2009<\u20090.05). Decreased Nedd4L protein expression correlated with clinical stage, pathological grade, lymph node metastasis and survival (P\u2009<\u20090.05).
Answer: Nedd4L protein expression may be an independent prognostic marker of ovarian cancer development.
Output (English): Is nedd4L expression decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue?