Task: Named Entity Recognition
Input (English):  Mutation of either Tyr248 , Tyr357 , or Tyr462 to phenylalanine reduced transcription from a c - fos promoter relative to wild - type BAP / TFII - I in transfected COS - 7 cells , consistent with the interpretation that phosphorylation at these sites contributes to transcriptional activation .
Output (English): c - fos