Task: Question Answering
Input (English): Question: The validation of an analytical method includes: 
 Options:  <1> Validate the analytical process as a whole, validate the range of concentrations in which it is applied and validate the method in each of the matrices to which it will be applied. <2> It only includes validating the range of concentrations in which it is applied. <3> It only includes validating the method in each of the matrices to which it will be applied. <4> It is only necessary to validate the treatment stages of the samples prior to the analytical measurement. <5> It is only necessary to validate the instrumentation by means of suitable calibrations.
Output (English): 1