Task: Question Answering
Input (English): Question: Indicate the wrong option in relation to the most frequent adverse reactions produced by the following drugs: 
 Options:  <1> Penicillins: permanent alteration of the coloring of the teeth. <2> Clindamycin: diarrhea. <3> Quinolones: headaches. <4> Aminoglycosides: ototoxicity. <5> Tetracyclines: photosensitivity.
Output (English): 1