Task: Question Answering
Input (English): Question: The state of adaptation characterized by the diminution of the response to the same amount of drug or the need for a higher dose to cause the same degree of pharmacological effect, defines: 
 Options:  <1> The adaptation to a drug. <2> The route of administration. <3> Intoxication <4> Tolerance to a drug <5> Addictive behavior
Output (English): 4