Task: Question Answering
Input (English): Question: The control of the acid-peptic disease is mainly achieved with PPIs (proton pump inhibitors). The PPIs: 
 Options:  <1> They induce the maximum inhibition of gastric secretion after 3-5 days. <2> They are less effective than H-2 antagonists. <3> They are used as monotherapy to eradicate Helicobacter pylori. <4> They have a faster onset of action than H-2 antagonists. <5> They are not useful in the treatment of stress ulcers.
Output (English): 1