Task: Question Answering
Input (English): Question: In the urea cycle: 
 Options:  <1> Enzymes that participate are located in the mitochondria. <2> Genetic defects can be treated with benzoate. <3> An intermediate metabolite is N-acetylglutamate. <4> Lysine is synthesized. <5> Carbamylphosphate synthetase II intervenes.
Output (English): 2