Task: Question Answering
Input (English): Question: When in a laboratory report we observed that the patient presents an increase in the concentration of transferrin with a decrease in its saturation, we can think of: 
 Options:  <1> Pernicious anemia. <2> Sickle-cell anaemia. <3> Thalassemia major. <4> Hereditary spherocytosis. <5> Anemia due to iron deficiency.
Output (English): 5