Task: Question Answering
Input (English): Question: Metformin is recommended as initial treatment in most consensus of treatment of type 2 diabetes, for efficacy, safety and price; However, its use has some limitations and it is obligatory to suspend it in some clinical situations. In which of the following situations would you NOT consider stopping this treatment? 
 Options:  <1> Introduction of long-acting insulin analogue due to poor metabolic control. <2> Alcohol intake greater than 50 g / day as usual. <3> CT scan with intravenous contrast. <4> Diarrheic picture with elevated plasma Cr at 2.5 mg / dL. <5> Acute ischemia of the lower extremities with significant tissue hypoxia.
Output (English): 1