Task: Question Answering
Input (English): Question: Topoisomerases: 
 Options:  <1> They modify the degree of DNA supercoiling. <2> They are a type of DNA polymerases. <3> They bind to the single-stranded DNA to prevent the double helix from forming. <4> They exhibit exonuclease activity. <5> They synthesize dNTPs.
Output (English): 1