Task: Question Answering
Input (English): Question: How does the increase in temperature affect the reaction between antigen and antibody? 
 Options:  <1> Increases the reaction rate and decreases binding affinity. <2> It decreases the reaction rate and increases the binding affinity. <3> Increases the reaction rate and binding affinity. <4> Decreases the reaction rate and binding affinity. <5> None of the above options is correct.
Output (English): 1