Task: Question Answering
Input (English): Question: The value of the admitted daily intake (ADI) of a food additive can be calculated from the following previously obtained data in animals: 
 Options:  <1> Level with no observed adverse effect (NOAEL). <2> Lower level with observed adverse effect (LOAEL). <3> Safety margin (MOS). <4> Toxic interval (IT). <5> Toxicity limit value (TLV).
Output (English): 1