Task: Question Answering
Input (English): Question: In patients with Chronic Obstructive Pulmonary Disease, which treatments listed below are contraindicated due to the effect they cause: 
 Options:  <1> Bronchodilators, both short and long acting. <2> Mucolytics and expectorants to reduce the viscosity of secretions. <3> Oxygen that in the long term reduces the mortality of the patient with COPD. <4> Respiratory depressants such as opioids and barbiturates. <5> Antibiotics for patients with repeated pulmonary infections.
Output (English): 4