Task: Question Answering
Input (English): Question: The cyclization of monosaccharides: 
 Options:  <1> It is an enzymatically catalyzed reaction. <2> It gives rise to enantiomers D and L. <3> It happens in the trios and tetrosas. <4> Generates a new asymmetric C, called anomeric C. <5> In ketoses it is produced by the formation of a hemiacetal bond.
Output (English): 4