Task: Question Answering
Input (English): Question: Acetylation of histones affects transcription: 
 Options:  <1> Blocking the incorporation of other components of the transcription machinery. <2> Preventing the remodeling of chromatin. <3> Facilitating the action of helicases. <4> Decreasing sensitivity to nuclear receptors. <5> Reducing the affinity of histones for DNA.
Output (English): 5