Task: Question Answering
Input (English): Question: The neurofibrillary tangles are anomalous structures that are observed in Alzheimer's patients and that consist of: 
 Options:  <1> Neurons in process of extinction by accumulations of intertwined filaments of tau protein that alter the transport of substances in the cytoplasm. <2> Extracellular deposits containing a nucleus of beta-amylase protein surrounded by degenerating axons and dendrites. <3> Proteins that serve to facilitate the production and transport of a cerebral neurotropic factor. <4> Accumulation of astrocytes and microgliocytes with the ability to react to external pathogens. <5> Proteins produced by a defective gene that increases the likelihood of Parkinson's disease.
Output (English): 1