Task: Question Answering
Input (English): Question: The magnitude of the steady state plasma concentration that is reached when a monocompartmental drug is administered in continuous perfusion is conditioned by: 
 Options:  <1> The time the perfusion is maintained. <2> The relationship between the rate of drug entry into the body (mg / h) and the elimination rate constant. <3> The relationship between the speed of entry to the body (mg / h) and the half-life of elimination of the drug. <4> The relationship between the speed of entry to the body (mg / h) and plasma clearance. <5> The administration of a rapid intravenous shock dose at the start of treatment.
Output (English): 4