Task: Question Answering
Input (English): Question: Which of the following statements is INCORRECT in relation to the alterations of the acid-base balance? 
 Options:  <1> The arterial pH is regulated by the Henderson-Hasselbach equation and is 7.35-7.45. <2> Hypercapnia (increase in PaCO2) is a consequence of the increase in CO2 production. <3> Metabolic acidosis occurs due to increased endogenous acid production, acid accumulation and / or loss of bicarbonates. <4> In patients with lactic acidosis it is common to find an anion gap or difference greater than 12 mmol / L. <5> The use of alkalizing solutions should be reserved for cases of severe acidemia with ph <7.20.
Output (English): 2