Task: Question Answering
Input (English): Question: In animals, where is most of the extracellular material components synthesized ?: 
 Options:  <1> In the smooth endoplasmic reticulum. <2> In the rough endoplasmic reticulum. <3> In the extracellular layer itself. <4> In the plasma membrane. <5> In the cytoplasm of the cell.
Output (English): 2