Task: Question Answering
Input (English): Question: GnRH (ganodorelin) is a hypothalamic decapeptide that is secreted in a pulsatile manner. Lately a series of analogues have been developed that: 
 Options:  <1> All of them inhibit prolonged secretion of LH and FSH. <2> All of them are GnRH receptor agonists. <3> Goserelin and buserelin are antagonists of the GnRH receptor. <4> The prolonged treatment gives rise to a typical symptomatology of an excess of gonadal steroids. <5> GnRH agonists are contraindicated in prostate and breast cancer.
Output (English): 1