Task: Question Answering
Input (English): Question: Inhibitors of hydroxymethyl-glutaryl-CoA reductase (HMG-CoA reductase), such as statins: 
 Options:  <1> They increase intracellular cholesterol synthesis. <2> They cause a decrease in the number of LDL receptors present on the surface of hepatocytes. <3> They decrease the intracellular synthesis of triacylglycerides. <4> They diminish intracellular cholesterol synthesis and induce the expression of LDL receptors. <5> They increase the synthesis of steroid hormones.
Output (English): 4