Task: Question Answering
Input (English): Question: For bi-component drugs it is true that: 
 Options:  <1> The apparent volume of the distribution decreases with time from a maximum value to a value that becomes constant. <2> The apparent volume of distribution as a function of the area is greater than the apparent volume of distribution in the steady state of equilibrium. <3> The apparent volume of distribution is constant over time. <4> The so-called initial distribution volume is greater than the apparent volume of distribution in phase . <5> The apparent volume of distribution calculated by extrapolation is less than the apparent volume of distribution in the steady state equilibrium.
Output (English): 2