Task: Question Answering
Input (English): Question: Serum disease is a hypersensitivity: 
 Options:  <1> Mediated by IgE. <2> Against molecules of the extracellular matrix. <3> Mediated by deposition of immune complexes in certain tissues. <4> With formation of granulomas. <5> With activation of mast cells associated with blood vessels.
Output (English): 3