Task: Question Answering
Input (English): Question: The increase in standard free energy of ATP hydrolysis depends, among others, on the following structural characteristic: 
 Options:  <1> Its polar character. <2> Its amphipathic nature <3> Its stabilization by resonance. <4> Of the phosphoryl group number it contains. <5> Of the cation with which the soluble salt forms.
Output (English): 3