Task: Question Answering
Input (English): Question: The development of generic drugs is based on the evaluation of the bioequivalence of the generic compared to a reference product already marketed. This concept refers to: 
 Options:  <1> The evaluation of equivalence in clinical efficacy trials. <2> The assessment of similarity in clinical trials of tolerance. <3> The equivalence in the distribution process of a drug and, therefore, to the verification that it has the same concentrations in the place of action. <4> The evaluation of pharmacokinetic equivalence. <5> The verification of a similar effect of the factors that influence the bioavailability of a drug.
Output (English): 4