Task: Answer Verification
Input (English): Question: Is cytoplasm-to-nucleus shuttling of thyroid hormone receptor-beta1 ( Trbeta1 ) directed from a plasma membrane integrin receptor by thyroid hormone?
Answer: TR-GFP translocation in the presence of T(4) requires activation of extracellular-regulated protein kinases 1/2 (ERK1/2). Inhibition of T(4)-binding to alphavbeta3 with anti-alphavbeta3 or Arg-Gly-Asp (RGD) peptide blocks T(4)-stimulated GFP-TR nuclear translocation, as do the hormone-binding inhibitor tetraiodothyroacetic acid (tetrac) and the ERK1/2 inhibitor, PD98059. TR1 is an ERK1/2 substrate.
Output (English): yes