Task: Answer Verification
Input (English): Question: Is aDAM17 a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer?
Answer: ADAM17 is a Western diet-inducible enzyme activated by CXCL12-CXCR4 signaling, suggesting the pathway: Western diet→CXCL12→CXCR4→ADAM17→TGFα→EGFR. ADAM17 might serve as a druggable target in chemoprevention strategies. Clin Cancer Res; 1-13. ©2016 AACR.
Output (English): yes