Task: Answer Verification
Input (English): Question: Does peginterferon-α improve early peripheral blood HBV-specific T-cell responses in HBeAg-negative chronic hepatitis?
Answer: IFN-α did not improve peripheral blood HBV-specific T-cell responses in the first 24 weeks of treatment, consistent either with a predominant antiviral/antiproliferative effect or with an immunomodulatory activity on other arms of the immune system which were not analyzed in our study. A better pre-treatment ex vivo IFN-γ production was associated with better chances to control HBV replication during therapy and represents a promising predictor of IFN efficacy.
Output (English): no