Task: Answer Verification
Input (English): Question: Does tissue plasminogen activator promote postischemic neutrophil recruitment via its proteolytic and nonproteolytic properties?
Answer: Endogenously released tPA promotes neutrophil transmigration to reperfused tissue via proteolytic activation of plasmin and gelatinases. As a consequence, tPA on transmigrating neutrophils disrupts endothelial junctions allowing circulating tPA to extravasate to the perivascular tissue, which, in turn, amplifies neutrophil recruitment through the activation of mast cells and release of lipid mediators.
Output (English): yes