Task: Answer Verification
Input (English): Question: Is the paraoxonase-1 pathway a major bioactivation pathway of clopidogrel in vitro?
Answer: This in vitro study shows that the contribution of PON1 to clopidogrel metabolism is limited at clinically relevant concentrations. Moreover, CYP2C19, CYP2B6 and CYP3A play important roles in the bioactivation of clopidogrel.
Output (English): no