Task: Answer Verification
Input (English): Question: Does nox4 mediate the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells?
Answer: The NADPH oxidase inhibitors DPI and S 17834 as well as Nox4 silencing decreased PAI-1 synthesis in human cultured endothelial cells demonstrating the involvement of the constitutively active Nox4-containing NADPH oxidase in ROS-mediated PAI-1 transcription via p38 MAPK pathways. NADPH oxidase targeting with inhibitors such as S17834 could be an interesting strategy to decrease both oxidative stress and PAI-1 synthesis.
Output (English): yes