Task: Answer Verification
Input (English): Question: Does p-glycoprotein modulation by valspodar and cyclosporin increase tumor uptake of doxorubicin administered via isolated lung perfusion to rats bearing sarcoma lung metastases?
Answer: P-gp modulation with cyclosporin or valspodar fails to increase the tumor uptake of doxorubin administered by A-ILP. Other reasons for low doxorubicin penetration in tumor, such as high interstitial fluid pressure or tumor vasculature barrier, or alternate cell membrane drug transporters, need to be examined for a better understanding of impaired doxorubicin delivery to tumor.
Output (English): no