Task: Answer Verification
Input (English): Question: Is myD88-dependent toll-like receptor signalling a requirement for fetal islet xenograft rejection in mice?
Answer: Islet xenograft rejection was found to persist in MyD88-/- mice. Despite a relatively lower expression of the Th1-associated cytokines IFN-gamma and IL12-p40 within the xenograft area, both the time course and morphological pattern of the rejection were essentially similar to that found in normal animals. Hence, MyD88-dependent TLR signalling does not appear to be a crucial component of acute cellular xenograft rejection.
Output (English): no