Task: Answer Verification
Input (English): Question: Is iPS cell-derived cardiogenicity hindered by sustained integration of reprogramming transgenes?
Answer: A disproportionate stemness load, caused by integrated transgenes, affects the cardiogenic competency of iPS cells. Offload of transgenes in engineered iPS cells ensures integrity of cardiac developmental programs, underscoring the value of nonintegrative nuclear reprogramming for derivation of competent cardiogenic regenerative biologics.
Output (English): yes