Task: Answer Verification
Input (English): Question: Does inhibition of proteasome-mediated glucocorticoid receptor degradation restore nitric oxide bioavailability in myocardial endothelial cells in vitro?
Answer: Summarising our results, we propose a new mechanism involved in the regulation of NO signalling by GCs in myocardial endothelial cells. We suggest that a sufficient GR protein expression plays a crucial role for the management of GC-induced harmful adverse effects, including deregulations of vasorelaxation arising from disturbed NO biosynthesis.
Output (English): yes