Task: Answer Verification
Input (English): Question: Is bRAF mutation analysis a valid tool to implement in Lynch syndrome diagnosis in patients classified according to the Bethesda guidelines?
Answer: The prevalence of BRAF mutations in CRC patients is not high but extremely correlated with MSI and risk categories as BG, whereas they are absent in LS patients. BRAF mutation detection can reduce the need for MMR gene analysis in a small (but not negligible) proportion of MSI patients (7%), with a positive impact on the financial and psychological costs of unnecessary tests.
Output (English): yes