Task: Answer Verification
Input (English): Question: Are the expression of efflux and uptake transporters regulated by statins in Caco-2 and HepG2 cells?
Answer: These findings reveal that statins exhibits differential effects on mRNA expression of drug transporters, and this effect depends on the cell type. Furthermore, alterations in the expression levels of drug transporters in the liver and/or intestine may contribute to the variability in oral disposition of statins.Acta Pharmacologica Sinica (2009) 30: 956-964; doi: 10.1038/aps.2009.85; published online 22 June 2009.
Output (English): yes