Task: Answer Verification
Input (English): Question: Are high T3 , Low T4 Serum Levels in Mct8 Deficiency Caused by Increased Hepatic Conversion through Type I Deiodinase?
Answer: Our data suggest that although hepatic Dio1 activity is increased in Mct8-deficient mice, it does not cause the observed abnormal circulating thyroid hormone levels. Since global inactivation of Dio1 in Mct8-deficient mice does normalize circulating thyroid hormone levels, the underlying mechanism and relevant tissues involved remain to be elucidated.
Output (English): no