Task: Answer Verification
Input (English): Question: Does bladder stretch alter urinary heparin-binding epidermal growth factor and antiproliferative factor in patients with interstitial cystitis?
Answer: Bladder stretch increased HB-EGF and conversely reduced antiproliferative factor activity in urine from patients with interstitial cystitis but not controls up to 2 weeks after distention. These results provide additional evidence for the possible role of antiproliferative factor and decreased HB-EGF in the pathophysiology of interstitial cystitis. To our knowledge this is also the first human study to show that in vivo bladder stretch can alter urinary factors that regulate cell growth.
Output (English): yes