Task: Answer Verification
Input (English): Question: Do serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants?
Answer: Diverse proinflammatory and algesic agents activate melagatran-sensitive serine proteases that cause inflammation and pain by a PAR2-mediated mechanism. By inducing self-activating proteases, PAR2 amplifies and sustains inflammation and pain. Serine protease inhibitors can attenuate the inflammatory and algesic effects of diverse stimuli, representing a useful therapeutic strategy.
Output (English): yes