Task: Answer Verification
Input (English): Question: Is p21 deficiency susceptible to osteoarthritis through STAT3 phosphorylation?
Answer: The lack of p21 has catabolic effects by regulation of aggrecan and MMP-13 expression through STAT3 phosphorylation in the cartilage tissue. p21 may function as a regulator of transcriptional factors other than the inhibitor of cell cycle progression in the cartilage tissue. Thus, the regulation of p21 may be a therapeutic strategy for the treatment of OA.
Output (English): yes