Task: Answer Verification
Input (English): Question: Are nR5A1 ( SF-1 ) mutations a major cause of primary ovarian insufficiency?
Answer: Our study in a large cohort of patients with POI showed the prevalence of NR5A1 mutations to be low (1.6%, upper 95% confidence interval 3.5%). Moreover, no functional impact was observed. Overall, in contrast with the initial report, our results exclude NR5A1 mutations as a major genetic cause of POI.
Output (English): no