Task: Answer Verification
Input (English): Question: Does deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice?
Answer: These results demonstrate that G6pc2 is an important driver for the selection and expansion of islet-reactive CD8(+) T cells infiltrating NOD/ShiLtJ islets. However, autoreactivity to G6pc2 is not essential for the emergence of autoimmune diabetes. The results remain consistent with previous studies indicating that insulin may be the primary autoimmune target, at least in NOD/ShiLtJ mice.
Output (English): no