Task: Answer Verification
Input (English): Question: Does e2F4 regulatory program predict patient survival prognosis in breast cancer?
Answer: We defined a prognostic signature, the E2F4 regulatory activity score, and showed it to be significantly predictive of patient outcome in breast cancer regardless of treatment status and the states of many other clinicopathological variables. It can be used in conjunction with other breast cancer classification methods such as Oncotype DX to improve clinical outcome prediction.
Output (English): yes