Task: Answer Verification
Input (English): Question: Does local lentiviral short hairpin RNA silencing of CCR2 inhibit vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice?
Answer: Vascular CCR2 contributes to vein graft disease, and local application of shRNA against CCR2 to the vessel wall prevents vein graft thickening in hypercholesterolemic mice, suggesting that local overexpressing of shRNA using organ-targeted lentiviral gene delivery may be a promising therapeutic tool to improve vein graft disease in bypassed patients.
Output (English): yes