Task: Answer Verification
Input (English): Question: Does progression-free survival remain poor over sequential lines of systemic therapy in patients with BRAF-mutated colorectal cancer?
Answer: PFS is expectedly poor for patients with BRAF-mutated metastatic colorectal cancer. Despite the ascertainment bias present (with testing preferentially performed in patients suitable for clinical trials in refractory disease), these data provide historic controls suitable for future study design and support the idea that novel therapeutic options are essential in this population.
Output (English): yes