Task: Answer Verification
Input (English): Question: Does complex pattern of interaction between in utero hypoxia-ischemia and intra-amniotic inflammation disrupt brain development and motor function?
Answer: Prenatal TSHI and TSHI + LPS lead to different patterns of injury with respect to myelination, axon integrity and gait deficits. Dual injury leads to acute alterations in glial response and cellular inflammation, while TSHI alone causes more prominent chronic white matter and axonal injury. Both injuries cause significant gait deficits. Further study will contribute to stratification of injury mechanisms in preterm infants, and guide the use of promising therapeutic interventions.
Output (English): yes