Task: Answer Verification
Input (English): Question: Is rat middle cerebral artery occlusion a suitable model for the study of stroke-induced spontaneous infections?
Answer: Inflammatory and infection changes in Wistar rats subjected to MCAO models may be attributed not only to the brain ischemic injury but to the surgical aggression and/or anaesthetic stress. Consequently, we suggest that stroke-induced immunodepression in ischemic experimental models should be interpreted with caution in further experimental and translational studies, at least in rat stroke models that entail cervicotomy and cranial trepanation.
Output (English): no