Task: Answer Verification
Input (English): Question: Does eIF2A-dependent translational arrest protect leukemia cells from the energetic stress induced by NAMPT inhibition?
Answer: We identified EIF2A phosphorylation as a novel early molecular event occurring in response to NAMPT inhibition and mediating protein synthesis arrest. In addition, our data suggest that tumors exhibiting an impaired LBK1- AMPK- EIF2A response may be especially susceptible to NAMPT inhibitors and thus become an elective indication for this type of agents.
Output (English): yes