Task: Answer Verification
Input (English): Question: Does the intervertebral disc contain intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration?
Answer: We have established autonomous circadian clocks in mouse and human IVD cells which respond to age and cytokines, and control key pathways involved in the homeostasis of IVDs. Genetic disruption to the mouse IVD molecular clock predisposes to IVD degeneration. These results support the concept that disruptions to circadian rhythms may be a risk factor for degenerative IVD disease and low back pain.
Output (English): yes