Task: Answer Verification
Input (English): Question: Does nitric oxide inhibit IFN regulatory factor 1 and nuclear factor-kappaB pathways in rhinovirus-infected epithelial cells?
Answer: Nitric oxide blocks rhinovirus-mediated activation and nuclear translocation of both NF-kappaB and IRF-1. NO also directly inhibits the binding of each of these transcription factors to their respective recognition sites in the CXCL10 promoter. In addition, the ability of HRV-16 to induce epithelial expression of IRF-1 is dependent, at least in part, on viral activation of NF-kappaB.
Output (English): yes