Task: Answer Verification
Input (English): Question: Do montelukast and zafirlukast affect the pharmacokinetics of the CYP2C8 substrate pioglitazone?
Answer: Montelukast and zafirlukast do not increase the plasma concentrations of pioglitazone, indicating that their inhibitory effect on CYP2C8 is negligible in vivo, despite their strong inhibitory effect on CYP2C8 in vitro. The results highlight the importance of in vivo interaction studies and of the incorporation of relevant pharmacokinetic properties of drugs, including plasma protein binding data, to in vitro-in vivo interaction predictions.
Output (English): no