Task: Answer Verification
Input (English): Question: Does a Rb1 promoter variant with reduced activity contribute to osteosarcoma susceptibility in irradiated mice?
Answer: This is the first experimental demonstration of a functional and genetic link between reduced Rb1 expression from a common promoter variant and increased tumor risk after radiation exposure. We propose that a reduced Rb1 expression by common variants in regulatory regions can modify the risk for a malignant transformation of bone cells after radiation exposure.
Output (English): yes