Task: Answer Verification
Input (English): Question: Does inactivation of patched1 in murine chondrocytes cause spinal fusion without inflammation?
Answer: Our findings indicate that chronic activation of the HH signal pathway in spinal chondrocytes can trigger an ankylosing spine morphology without immune cell contributions. Hence, the destruction of cartilage and loss of axial joint integrity can result from chondrocyte-intrinsic defects of monogenic origin.
Output (English): yes