Task: Answer Verification
Input (English): Question: Does pretreatment with ranitidine reduce the bioavailability of orally administered topotecan?
Answer: Administration of ranitidine prior to oral topotecan resulted in a similar extent of absorption. A slightly faster rate of absorption of topotecan was also observed, which is unlikely to be of clinical significance. Dosage adjustments of orally administered topotecan should not be necessary in patients who are pretreated with ranitidine, an H2 antagonist, or another agent that comparably raises gastric pH.
Output (English): no