Task: Answer Verification
Input (English): Question: Do large deletions play a minor but essential role in congenital coagulation factor VII and X deficiencies?
Answer: Large deletions play a minor but essential role in the mutational spectrum of the F7 and F10 genes. Copy number analyses (e. g. MLPA) should be considered if sequencing cannot clarify the underlying reason of an observed coagulopathy. Of note, in cases of combined FVII/FX deficiency, a deletion of the two contiguous genes might be part of a larger chromosomal rearrangement.
Output (English): yes