Task: Answer Verification
Input (English): Question: Is malonate as a ROS product associated with pyruvate carboxylase activity in acute myeloid leukaemia cells?
Answer: This study extends the interest in the PC activity in solid cancers to include leukaemias and further demonstrates the value of tracer-based NMR approaches in generating a more accurate picture of the flow of carbons and metabolites within the increasingly inappropriately named Krebs cycle. Moreover, our studies indicate that the PC activity in cancer cells can be exploited as an Achilles heel by using treatments, such as BaP, that elevate ROS production.
Output (English): yes