Task: Answer Verification
Input (English): Question: Does tryptophan depletion modify response to CCK-4 challenge in patients with panic disorder after treatment with citalopram?
Answer: This study demonstrates that an acute lowering of brain 5-HT availability with TD does not affect response to a CCK-4 challenge in PD patients successfully treated with citalopram. Thus, the reduction of CCK-4 sensitivity following SSRI-treatment in patients with PD may be related to mechanisms other than 5-HT availability in the brain, possibly to a reduction in brain cholecystokinin receptor sensitivity.
Output (English): no