Task: Answer Verification
Input (English): Question: Is early systemic sclerosis : serum profiling of factors involved in endothelial , T-cell , and fibroblast interplay marked by elevated interleukin-33 levels?
Answer: Our study suggests that an endothelial, T-cell and fibroblast activation can be present in patients with early SSc and it is associated with a distinct profile of circulating factors involved in the cross-talk of these cells. The marked increase of IL-33 in early SSc patients suggests new routes of investigation of cell-cell dynamics in target tissues predating overt disease manifestations, thus opening to new therapeutic approaches.
Output (English): yes