Task: Answer Verification
Input (English): Question: Does cinacalcet affect the activity of cytochrome P450 3A enzymes , a metabolic pathway for common immunosuppressive agents : a randomized , open-label , crossover , single-centre study in healthy volunteers?
Answer: Once-daily administration of cinacalcet did not alter the pharmacokinetics of midazolam relative to administration of midazolam alone. These data suggest that cinacalcet administration does not affect CYP3A activity, and thus would not have an effect on any drug eliminated via CYP3A, including some commonly used immunosuppressant therapies.
Output (English): no