Task: Answer Verification
Input (English): Question: Does a melanoma cell state distinction influence sensitivity to MAPK pathway inhibitors?
Answer: Although most BRAF(V600)-mutant melanomas are sensitive to RAF and/or MEK inhibitors, a subset fails to respond to such treatment. This study characterizes a transcriptional cell state distinction linked to MITF and NF-κB that may modulate intrinsic sensitivity of melanomas to MAPK pathway inhibitors.
Output (English): yes