Task: Answer Verification
Input (English): Question: Is reverse interferon signature characteristic of antigen-presenting cells in human and rat spondyloarthritis?
Answer: Our results suggest that expression of HLA-B27 leads to a defect in IFNγ signaling in antigen-presenting cells in both B27-transgenic rats and SpA patients, which may result in Th17 expansion and Treg cell alteration (as shown in B27-transgenic rats) and contribute to disease pathogenesis.
Output (English): yes