Task: Answer Verification
Input (English): Question: Does short-term cortisol infusion in the brachial artery , with and without inhibiting 11 beta-hydroxysteroid dehydrogenase , alter forearm vascular resistance in normotensive and hypertensive subjects?
Answer: In both normotensive and hypertensive subjects, high-dose cortisol infusion both with and without 11 beta-HSD inhibition did not change FVR either immediately or after 2 h. We could not demonstrate in vivo 11 beta-HSD activity in the forearm vascular tissues. When binding of cortisone to CBG is changed, e.g. during cortisol infusion, arterio-venous changes in cortisone cannot reliably be used to assess (alterations in) local 11 beta-HSD activity.
Output (English): no