Task: Answer Verification
Input (English): Question: Does paroxetine affect metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers?
Answer: Multiple-dose paroxetine intake affects both metoprolol pharmacokinetics and pharmacodynamics and suggests that when paroxetine is added to an ongoing metoprolol therapy, caution is warranted and a reduction of the metoprolol dose may be required to prevent undesired adverse effects.
Output (English): yes