Task: Answer Verification
Input (English): Question: Is krüpple-like factor 5 required for proper maintenance of adult intestinal crypt cellular proliferation?
Answer: These results indicate that Klf5 is necessary to maintain adult intestinal crypt proliferation and proper cellular differentiation. Rapid replacement of Klf5-mutant crypts with wildtype cells and reduction of stem cell markers suggests further that Klf5 is required for self renewal of intestinal stem cells.
Output (English): yes