Task: Answer Verification
Input (English): Question: Does phosphatidylinositol 4,5-bisphosphate induce actin-based movement of raft-enriched vesicles through WASP-Arp2/3?
Answer: Sphingolipid-cholesterol rafts are preferred platforms for membrane-linked actin polymerization. This is mediated by in situ PIP(2) synthesis and tyrosine kinase signaling through the WASP-Arp2/3 pathway. Actin comets may provide a novel mechanism for raft-dependent vesicle transport and apical membrane trafficking.
Output (English): yes