Task: Answer Verification
Input (English): Question: Does metabolic efficiency promote protection from pressure overload in hearts expressing slow skeletal troponin I?
Answer: Expression of a single fetal myofilament protein into adulthood in the ssTnI-transgenic mouse heart induced downregulation of the gene expression response for pyruvate dehydrogenase kinase to pressure overload. The consequence of elevated pyruvate oxidation in ssTnI during TAC reduced anaplerotic flux, ameliorating inefficiencies in glucose oxidation, with energetic and functional protection against cardiac decompensation.
Output (English): yes