Task: Answer Verification
Input (English): Question: Do altered intracellular sorting signals influence the efficacy of genetic melanoma vaccines incorporating helper determinants in mice?
Answer: Altered intracellular sorting signals do not significantly influence the efficacy of genetic melanoma vaccines incorporating helper determinants in our model system. These results further support the concept that linkage of immunogenic helper sequences can be successfully applied for antigen-specific immunotherapy of melanoma and provide a scientific basis for the translation of this strategy in future clinical applications.
Output (English): no