Task: Answer Verification
Input (English): Question: Does pharmacological and genetic inhibition of NADPH oxidase reduce brain damage in different models of perinatal brain injury in newborn mice?
Answer: NADPH oxidase is upregulated after hypoxia-ischemia and activated microglia cells are a possible source of Nox2-derived ROS. In contrast to findings in adult brain, NADPH oxidase does not significantly contribute to the pathogenesis of perinatal brain injury. Results obtained in adult animals cannot be transferred to newborns and inhibition of NADPH oxidase should not be used in attempts to attenuate injury.
Output (English): no