Task: Answer Verification
Input (English): Question: Does interleukin-5 influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo?
Answer: We find that IL-5 is not necessary for differential splicing to occur in vivo, as all three forms of the IL-5R alpha are detected in both strains of IL-5 gene-deleted mice, with ratios of transcript expression (transmembrane : soluble 1 : soluble 2) that were indistinguishable from their wild-type counterparts. Differential splicing does vary markedly between strains, potentially because of local effects of strain-specific polymorphisms.
Output (English): no