Task: Answer Verification
Input (English): Question: Are v600E BRAF mutations alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumours?
Answer: BRAF mutations represent an alternative molecular pathway in the early tumorigenesis of a subset of KIT/PDGFRA wild-type GISTs and are per se not associated with a high risk of malignancy. Mutations in KIT, PDGFRA and BRAF were mutually exclusive in this study. Results from this and a previous study indicate that BRAF-mutated GISTs show a predilection for the small bowel (four of five tumours), but this needs further evaluation in larger studies.
Output (English): yes