Task: Answer Verification
Input (English): Question: Does ara-C affect formation of cancer cell DNA synthesome replication intermediates?
Answer: Our results indicate that ara-C's action on DNA replication is mediated primarily through DNA polymerase alpha and suggest that this enzyme plays a key role in DNA synthetic initiation events. The results also provide definitive support for the use of the DNA synthesome as a unique and powerful model for analyzing the mechanism of action of anticancer drugs which directly affect DNA replication.
Output (English): yes