Task: Answer Verification
Input (English): Question: Is slow receptor dissociation a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists?
Answer: Although the β(2) -adrenoceptor agonists displayed a range of kinetic rate parameters, simulations at relevant drug concentrations suggest that receptor kinetics do not play an important role in determining onset of action in the clinic. In addition, it is unlikely that receptor kinetics exert an important influence on the duration of action of these agonists, as indacaterol (once daily dosing) had a shorter residency time at the receptor than salmeterol (twice daily dosing).
Output (English): no