Task: Answer Verification
Input (English): Question: Is cDX2 downregulation associated with poor differentiation and MMR deficiency in colon cancer?
Answer: We found that CDX2 downregulation is associated with MMR deficiency, right-sided tumors, and poor differentiation at both the mRNA and protein level. Whether CDX2 plays an active role in tumor progression in MSI/MMR-deficient tumors remains to be elucidated.
Output (English): yes