Task: Answer Verification
Input (English): Question: Does hepatic Notch2 deficiency lead to bile duct agenesis perinatally and secondary bile duct formation after weaning?
Answer: Cholangiocyte differentiation becomes progressively less dependent on NOTCH2 signaling with age, suggesting that ductal-plate formation is dependent on NOTCH2, but subsequent cholangiocyte differentiation is not.
Output (English): yes