Task: Answer Verification
Input (English): Question: Does thorax irradiation trigger a local and systemic accumulation of immunosuppressive CD4+ FoxP3+ regulatory T cells?
Answer: The response of the adaptive immune system to whole thorax irradiation is characterized by local immunoactivation and systemic immunosuppression. The transient accumulation of immunosuppressive CD4+ FoxP3+ Treg may be required to protect the lung against excessive inflammation-induced tissue damage. Further investigations shall define the mechanisms underlying the accumulation of Treg and their role for the pathogenesis of radiation-induced lung disease.
Output (English): yes