Task: Answer Verification
Input (English): Question: Do location and type of mutation in the LIS1 gene predict phenotypic severity?
Answer: In contrast to previous reports, our data suggest that neither type nor position of intragenic mutations in the LIS1 gene allows an unambiguous prediction of the phenotypic severity. Furthermore, patients presenting with mild cerebral malformations such as subcortical band heterotopia or cerebellar hypoplasia should be considered for genetic analysis of the LIS1 gene.
Output (English): no