Task: Answer Verification
Input (English): Question: Are tIMP1 , TIMP2 , and TIMP4 increased in aqueous humor from primary open angle glaucoma patients?
Answer: An imbalance among MMPs and TIMPs was found in glaucomatous aqueous humor samples, with a shift toward raised TIMP levels. This may result in the inhibition of MMP activity, leading to an altered ECM composition in the TM and thereby contributing to increased outflow resistance.
Output (English): yes