Task: Answer Verification
Input (English): Question: Does chronic administration of phenytoin induce efflux transporter overexpression in rats?
Answer: Overexpression of efflux transporters can be mediated by inducer agents like PHT in a local-concentration dependent manner, and it is reversible once the substance is removed from the body. The recovery of basal Pgp expression could allow the design of dosing schedules that optimize anticonvulsant therapy.
Output (English): yes