Task: Answer Verification
Input (English): Question: Does global transcriptional analysis reveal surface remodeling of Anaplasma marginale in the tick vector?
Answer: The ISE6 tick cell culture line is an acceptable model for early infection in tick salivary glands, and reveals disproportionate down regulation of surface protein genes in the tick. Transcriptional profiling in other cell lines may help us simulate additional microenvironments. Understanding vector-specific alteration of gene transcription, especially of surface protein encoding genes, may aid in the development of vaccines or transmission blocking therapies.
Output (English): yes