Task: Answer Verification
Input (English): Question: Does intracellular Enhanced Cyan Fluorescent Protein/Angiotensin II Modify Angiotensinogen Accumulation in Transgenic Mice?
Answer: ECFP/AngII transgene expression does not alter AGT mRNA or protein levels in major organs (kidney, liver, and brain) of transgenic mice. The altered blood pressure and kidney thrombosis observed in these transgenic mouse lines are not the result of increased intracellular AGT synthesis and resultant increases in free extracellular AngII. This finding is consistent with our published studies that indicate no increase in circulating AngII by radioimmunoassay.
Output (English): no