Task: Answer Verification
Input (English): Question: Does loss of Frzb and Sfrp1 differentially affect joint homeostasis in instability-induced osteoarthritis?
Answer: Using the DMM model, we demonstrated that FRZB and SFRP1 differentially modulate joint homeostasis in two distinct compartments of the joint. These data highlight the fine-tuning of Wnt signaling in joint homeostasis and disease, show differential regulation of the cascade in cartilage and subchondral bone, and provide further evidence for a role of endogenous Wnt modulators as key players in OA.
Output (English): yes