Task: Answer Verification
Input (English): Question: Is granulocyte-macrophage colony-stimulating factor responsible for residual thrombopoiesis in mpl null mice?
Answer: There was no additional effect seen as a result of loss of betac signaling. GM-CSF did not play a significant role in thrombopoiesis, even in combination with the absence of thrombopoietin signaling. These results highlight problems that can be encountered when studying introduced mutations in mice. They exemplify the importance of eliminating the influence of modifying genes when attributing biologic differences to specific introduced genetic alterations.
Output (English): no