Task: Answer Verification
Input (English): Question: Does pPARγ activation affect endothelin activity in non-diabetic patients with hypertension or hypercholesterolemia?
Answer: In non-diabetic patients with hypertension or hypercholesterolemia, pioglitazone improves insulin sensitivity, lipid profile, and inflammation but does not affect endothelin activity. Our data suggest that the determinants of endothelin-1 vascular activity in vivo may differ and/or be more complex than those suggested by the results of previous in vitro studies.
Output (English): no