Task: Answer Verification
Input (English): Question: Does active CREB1 promote a malignant TGFβ2 autocrine loop in glioblastoma?
Answer: TGFβ is considered a promising therapeutic target, and several clinical trials using TGFβ inhibitors are generating encouraging results. Here, we discerned the molecular mechanisms responsible for the aberrantly high levels of TGFβ2 found in certain tumors, and we propose biomarkers to predict the clinical response to anti-TGFβ therapies.
Output (English): yes