Task: Answer Verification
Input (English): Question: Does trimetazidine alter metabolic substrate oxidation in cardiac mitochondria of target patient population?
Answer: Using myocardial tissue from CAD patients, we found that trimetazidine (applied chronically in vivo or acutely in vitro) had no effect on cardiac fatty acid and carbohydrate oxidation, suggesting that the clinical effects of trimetazidine are unlikely to be due to its metabolic effects, but rather to an as yet unidentified intracardiac mechanism.
Output (English): no