Task: Answer Verification
Input (English): Question: Do malarial pigment haemozoin , IFN-gamma , TNF-alpha , IL-1beta and LPS stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno-purified human monocytes?
Answer: Results indicate that human monocytes fed or not with HZ/sHZ were constantly unable to express iNOS and generate NOS metabolites even after stimulation with IFN-gamma or a cytokine-LSP mix that were very active on HZ-fed murine phagocytic lines. Present data do not support the hypothesis that monocytes are mediators of anti-parasitic defence in clinical malaria via activation of iNOS and production of NO, and suggest caution in extrapolating data obtained with murine or hybrid systems to human malaria.
Output (English): no