Task: Answer Verification
Input (English): Question: Does pPAR-alpha dependent regulation of vanin-1 mediate hepatic lipid metabolism?
Answer: We show that hepatic vanin-1 is under extremely sensitive regulation by PPARα and that plasma vanin activity could serve as a readout of changes in PPARα activity in human subjects. In addition, our data propose a role for vanin-1 in regulation of hepatic TG levels during fasting.
Output (English): yes