Task: Answer Verification
Input (English): Question: Is insulin granule recruitment and exocytosis dependent on p110gamma in insulinoma and human beta-cells?
Answer: The G-protein-coupled PI3Kgamma is an important determinant of secretory granule trafficking to the plasma membrane, at least in part through the negative regulation of cortical F-actin. Thus, p110gamma activity plays an important role in maintaining a membrane-docked, readily releasable pool of secretory granules in insulinoma and human beta-cells.
Output (English): yes