Task: Answer Verification
Input (English): Question: Do variations in LOXL1 associated with exfoliation glaucoma affect amine oxidase activity?
Answer: The R141L and G153D variations in the NH(2)-terminal region of LOXL1 do not affect the amine oxidase activity of LOXL1. This is consistent with recent genetic findings on the reversal of risk alleles of R141L and G153D in different ethnic backgrounds. Our results suggest that other unknown genetic factors or molecular mechanisms may be more relevant to the development of XFG.
Output (English): no