Task: Answer Verification
Input (English): Question: Does systemic TNF blockade modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients -- a prospective clinical study?
Answer: Pro-inflammatory HMGB1 expression during rheumatoid synovitis was not consistently influenced by TNF-blocking therapy with infliximab. This suggests that TNF is not the main inducer of extranuclear HMGB1 during synovitis and that HMGB1 may represent a TNF-independent molecule that could be considered as a possible target for future therapeutic intervention in RA.
Output (English): no