Task: Answer Verification
Input (English): Question: Does the secretome of endothelial progenitor cells promote brain endothelial cell activity through PI3-kinase and MAP-kinase?
Answer: The present study demonstrates that EPC-derived paracrine factors substantially promote the angiogenic response of brain microvascular endothelial cells. In addition, our findings identified the PI3K/AKT and MEK/ERK pathways to play a central role in mediating these effects.
Output (English): yes