Task: Answer Verification
Input (English): Question: Do kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors?
Answer: DAAs that target NS5A rapidly inhibit intracellular assembly of genotype 1a virions. They also inhibit formation of functional replicase complexes, but have no activity against preformed replicase, thereby resulting in slow shut-off of viral RNA synthesis.
Output (English): yes