Task: Answer Verification
Input (English): Question: Does high TPMT enzyme activity explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment?
Answer: In this patient population with measured 6-MMP/6-TGN ratios, 19% of patients were preferential 6-MMP producers. The results show that high TPMT enzyme activity is not the major reason for preferential 6-MMP production in most patients with a high metabolite ratio. This suggests that there are one or more important alternative mechanisms for preferentially producing 6-MMP.
Output (English): no