Task: Answer Verification
Input (English): Question: Does transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuate K/BxN mouse serum-induced arthritis in vivo?
Answer: Disruption of GC signaling in osteoblasts significantly attenuates K/BxN mouse serum-induced autoimmune arthritis in mice. These data suggest that osteoblasts modulate the immune-mediated inflammatory response via a GC-dependent pathway.
Output (English): yes