Task: Answer Verification
Input (English): Question: Is human endogenous retrovirus ( HERV ) expression induced by treatment with the histone deacetylase ( HDAC ) inhibitors in cellular models of HIV-1 latency?
Answer: We show that HDAC inhibitors did not substantially increase the transcription of the analysed HERV env or pol genes, suggesting that histone acetylation is not crucial for controlling HERV expression in these experimental models and in ex vivo primary human T cells. Importantly, this indicates that unwanted HERV expression does not appear to be a barrier to the use of HDAC inhibitors in HIV-1 cure strategies.
Output (English): no