Task: Answer Verification
Input (English): Question: Does high glucose attenuate insulin-induced VEGF expression in bovine retinal microvascular endothelial cells?
Answer: Both insulin and high glucose can markedly increase VEGF expression in BRECs at the mRNA and protein level. We propose that insulin may upregulate VEGF expression through the PI3-K signalling pathway in BRECs, and high glucose may attenuate insulin-induced VEGF expression by impairing PI3-K signalling pathways.
Output (English): yes