Task: Answer Verification
Input (English): Question: Does iL-12 regulate B7-H1 expression in ovarian cancer-associated macrophages by effects on NF-κB signalling?
Answer: IL-12 upregulates the expression of B7-H1 in monocyte-derived macrophages, which is possible though inducing the secretion of IFN-γ and further activating the NF-κB signal pathway. However, IL-12 downregulates the expression of B7-H1 in THP-1-derived macrophages, associated with a lack of IFN-γ and inhibition of expression of IL-10.
Output (English): yes