Task: Answer Verification
Input (English): Question: Does hippocampal laminar distribution of tau relate to Alzheimer 's disease and age of onset?
Answer: Phospho-tau pathology, when prominent within both IML and OML, is associated with CERAD diagnosis of Definite AD and earlier age of onset in AD. Laminar patterns of tau deposition reflect regional involvements during disease course.
Output (English): yes