Task: Answer Verification
Input (English): Question: Does a common polymorphism in extracellular superoxide dismutase affect cardiopulmonary disease risk by altering protein distribution?
Answer: We conclude that EC-SOD provides optimal protection when localized to the compartment subjected to extracellular oxidative stress: thus, the redistribution of EC-SOD from the lung and pulmonary circulation to the extracellular fluids is beneficial in alveolar lung disease but detrimental in pulmonary vascular disease. These findings account for the discrepant risk associated with R213G in humans with lung diseases compared with cardiovascular diseases.
Output (English): yes