Task: Answer Verification
Input (English): Question: Does inhibition of peripheral FAAH depress activities of bladder mechanosensitive nerve fibers of the rat?
Answer: To our knowledge we report for the first time that inhibiting peripheral FAAH depresses the Aδ and C-fiber activity of primary bladder afferents via CB1 and CB2 receptors. CB antagonists alone exerted facilitatory effects on single unit afferent activity during bladder filling in rats. The endocannabinoid system may be involved in physiological control of micturition as regulators of afferent signals.
Output (English): yes