Task: Answer Verification
Input (English): Question: Does circulating atrial natriuretic peptide genetic association study identify a novel gene cluster associated with stroke in whites?
Answer: This is the first large-scale genetic association study of circulating NT-proANP levels performed with replication and functional assessment that identified genetic variants in the MTHFR-CLCN6-NPPA-NPPB cluster to be significantly associated with NT-proANP levels. The clinical significance of this variation is related to lower NT-proANP levels, higher blood pressures, and an increased risk of stroke in the general community.
Output (English): yes