Task: Answer Verification
Input (English): Question: Is [ Bevacizumab toxic to human anterior- and posterior-segment cultured cells ]?
Answer: In this study, a 10-fold concentration (compared with common clinical use) of the VEGF-blocking antibody bevacizumab had toxic effects on primary RPE. There was no toxicity for lower concentrations or toxicity to other cell types of the anterior and posterior segments. Therefore, the clinical use of bevacizumab at concentrations of 1-1.25 mg intravitreally seems to be safe.
Output (English): no