Task: Answer Verification
Input (English): Question: Is the differentially methylated region of MEG8 hypermethylated in patients with Temple syndrome?
Answer: Based on the observed MEG8-DMR DNA-hypermethylation and previously published data, we conclude that DNA-methylation of the MEG3- and MEG8-DMR is functionally dependent on the DNA-methylation pattern of the IG-DMR. The observed combination of epimutations is predicted to be associated with bi-allelic MEG3 and MEG8 expression in individuals with Temple syndrome.
Output (English): yes