Task: Answer Verification
Input (English): Question: Are p16INK4A gene alterations a prognostic indicator for survival in patients with hepatocellular carcinoma undergoing curative hepatectomy?
Answer: p16INK4A is altered frequently and early in HCC, being the predominant mechanism of inactivation promoter hypermethylation. The present results suggest that the p16INK4A gene plays an important role in the pathogenesis of HCC.
Output (English): no