Task: Answer Verification
Input (English): Question: Do cpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells?
Answer: The evidence presented suggests that the methylation of the CpG sites of the CRYAA promotor directly affect Sp1 binding, leading to down expression of CRYAA in human lens epithelial cells. Zebularine treatment could restore CRYAA expression in a dose- dependent and time- dependent pattern.
Output (English): yes