Task: Answer Verification
Input (English): Question: Does naked plasmid-mediated gene transfer to skeletal muscle ameliorate diabetes mellitus?
Answer: Skeletal muscle is a potentially useful platform for ectopic secretion of insulin using naked plasmid as a gene transfer vector. Injection at two sites 14 days before the onset of severe hyperglycemia is optimal. This approach could protect Type I diabetics from fatal ketoacidosis and enhance the action of agents that sensitize tissues to insulin in type II diabetes.
Output (English): yes