Task: Answer Verification
Input (English): Question: Is early reduction in number of T cells producing proinflammatory cytokines , observed after extracorporeal photopheresis , linked to apoptosis induction?
Answer: Since proinflammatory cytokines play a major role in the pathology of GvHD, their down-regulation post-ECP may produce a direct clinical benefit. The lowest number of IL2-, IFNgamma- and TNFalpha-expressing T cells occurred within the apoptotic population; however, Annexin V-negative T cells also demonstrated a marked reduction post-ECP. However, the lack of an increase in IL4 and IL10 expression indicates that this process was not a consequence of skewing toward a Th2 cytokine profile.
Output (English): no