Task: Answer Verification
Input (English): Question: Does next-generation sequencing reveal large connected networks of intra-host HCV variants?
Answer: Most intra-host variants are organized into distinct single-mutation components that are: well separated from each other, represent genetic distances between viral variants, robust to sampling, reproducible and likely seeded during transmission events. Facilitated by NGS, large components offer a novel evolutionary framework for genetic analysis of intra-host viral populations and understanding transmission, immune escape and drug resistance.
Output (English): yes