Task: Answer Verification
Input (English): Question: Does the cytoprotective effect of biglycan core protein involve Toll-like receptor 4 signaling in cardiomyocytes?
Answer: The core protein of exogenous biglycan protects myocardial cells from SI/R injury via TLR4-mediated mechanisms involving activation of ERK, JNK and p38 MAP kinases and increased NO production. The cytoprotective effect of rhBGNc is due to modulation of SI/R-induced changes in necrosis, apoptosis and autophagy.
Output (English): yes