Task: Answer Verification
Input (English): Question: Is irinotecan fluorouracil plus leucovorin superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer : results of CALGB 89803?
Answer: The addition of CPT-11 to weekly bolus FU plus LV did not result in improvement in DFS or OS in stage III disease, but did increase both lethal and nonlethal toxicity. This trial demonstrates that advances in the treatment of metastatic disease do not necessarily translate into advances in adjuvant treatment, and it reinforces the need for randomized controlled adjuvant studies.
Output (English): no