Task: Answer Verification
Input (English): Question: Does rSPO3 expand intestinal stem cell and niche compartments and drives tumorigenesis?
Answer: We provide in vivo evidence that RSPO3 stimulates the crypt stem cell and niche compartments and drives rapid intestinal tumorigenesis. This establishes RSPO3 as a potent driver of intestinal cancer and proposes RSPO3 as a candidate target for therapy in patients with colorectal cancer harbouring RSPO3 fusions.
Output (English): yes