Task: Answer Verification
Input (English): Question: Are the effects of high glucose on human endothelial cell growth and gene expression mediated by transforming growth factor-beta?
Answer: These combined observations indicate that (a) endothelial cells exposed to high glucose do not secrete TGF-beta in excess of control cells, (b) there are growth-inhibitory effects of high glucose that are independent of TGF-beta, and (c) high glucose and TGF-beta exert their effects through distinct pathways and at different loci.
Output (English): no