Task: Answer Verification
Input (English): Question: Does inhibition of notch signaling in combination with Paclitaxel reduce platinum-resistant ovarian tumor growth?
Answer: Inhibiting the Notch signaling cascade with a GSI reduces primary human xenograft growth in vivo. GSI synergized with conventional cytotoxic chemotherapy only in the platinum-resistant OvCa models with single agent paclitaxel. These findings suggest inhibition of the Notch pathway in concert with taxane therapy may hold promise for treatment of platinum-resistant OvCa.
Output (English): yes