Task: Answer Verification
Input (English): Question: Does cationic Nanogel-mediated Runx2 and Osterix siRNA Delivery decrease Mineralization in MC3T3 Cells?
Answer: Although mRNA and protein knockdown were confirmed as a result of RNAi treatments against Runx2 and Osx, complete elimination of mineralization processes was not achieved. RNAi targeting mid- and late-stage osteoblast differentiation markers such as ALP, osteocalcin, osteopontin, and bone sialoprotein) may produce the desired RNAi-nanogel nanostructured polymer HO prophylaxis.
Output (English): yes