Task: Answer Verification
Input (English): Question: Does in human IgA nephropathy uteroglobin play the role inferred from transgenic mice?
Answer: This first report of human IgA nephropathy after the publication of the mouse model shows that UG is not reduced in circulation and is even increased in IgA-Fn complexes. Because aberrant IgA1 glycosylation is the event initiating IgA nephropathy in humans, we speculate that the enhanced incorporation of UG into IgA-Fn complexes might represent feedback to reduce the formation of macromolecular aggregates.
Output (English): no