Task: Answer Verification
Input (English): Question: Does miR-1228 promote the proliferation and metastasis of hepatoma cells through a p53 forward feedback loop?
Answer: miR-1228 functions as an oncogene by promoting cell cycle progression and cell mobility and negatively regulates the expression of p53. p53 downregulation in turn leads to an increase in miR-1228 expression, thereby forming a positive feedback loop that contributes to cancerogenesis in HCC.
Output (English): yes