Task: Answer Verification
Input (English): Question: Does prolonged bacterial exposure to minocycline/rifampicin-impregnated vascular catheters affect antimicrobial activity of catheters?
Answer: Minocycline/rifampicin-impregnated catheters remain effective against MSSA, MRSA, MRSE and VRE, as evidenced by stable zones of inhibition following 21 day sequential exposure to these catheters. The increase in MIC of rifampicin for MRSA may be clinically relevant if the catheter remains in place for >12 days though the strain remained susceptible to minocycline, there was no concurrent increase in the MIC of other tested drugs, and the zones of inhibition remained stable.
Output (English): no