Task: Answer Verification
Input (English): Question: Are tP53 , BRCA1 , and BRCA2 tumor suppressor genes commonly mutated in survivors of Hodgkin 's disease with second primary neoplasms?
Answer: Despite features suggestive of genetic predisposition, the TP53, BRCA1, and BRCA2 genes were not frequently mutated in this cohort of HD patients developing SMNs. Larger studies of these genes or investigations of other genes involved in cellular DNA damage response pathways may identify host genetic factors that contribute to secondary tumorigenesis.
Output (English): no