Task: Answer Verification
Input (English): Question: Does hypoxia augment the calcium-activated chloride current carried by anoctamin-1 in cardiac vascular endothelial cells of neonatal mice?
Answer: Ano1 formed CaCC in CVECs of neonatal mice. Hypoxia enhances Ano1-mediated ICl ( C a) density via increasing its expression, altering the ratio of its splicing variants, sensitivity to membrane voltage and to Ca(2+) . Ano1 may play a role in the pathophysiological processes during ischaemia in heart, and therefore, Ano1 might be a potential therapeutic target to prevent ischaemic damage.
Output (English): yes