Task: Answer Verification
Input (English): Question: Are cDKN2A ( p16 ) and HRAS frequently mutated in vulvar squamous cell carcinoma?
Answer: Somatic mutations were detected in 62% of VSCCs. As expected, HPV infection and TP53-mutations play a key role in the development of VSCC, but CDKN2A(p16), HRAS, and PIK3CA-mutations were also frequently seen in HPV-negative patients. Patients with somatic mutations, especially HRAS-mutations, have a significantly worse prognosis than patients lacking these changes, which could be of importance for the development of targeted therapy.
Output (English): yes