Task: Answer Verification
Input (English): Question: Is nuclear localization of a1A-adrenergic receptors required for signaling in cardiac myocytes : an “ inside-out ” a1-AR signaling pathway?
Answer: Together, our data identify a novel, “inside-out” nuclear a1A-subtype/PKCd/cTnI-signaling pathway that regulates contractile function in adult cardiac myocytes. Importantly, these data help resolve the discrepancy between nuclear localization of a1-ARs and a1-AR-mediated physiologic function.
Output (English): yes