Task: Answer Verification
Input (English): Question: Does down-regulation of vascular alpha1-adrenoceptors account for the loss of vascular responsiveness to catecholamines in experimental cholestasis?
Answer: Since the affinity and number of vascular alpha1-adrenoceptors were unchanged in the face of elevated plasma concentrations of catecholamines in the BDL rats, we have concluded that down-regulation of vascular alpha1-adrenoceptors does not account for the vascular adrenergic hyporesponsiveness in experimental cholestasis.
Output (English): no