Task: Answer Verification
Input (English): Question: Do activation conditions determine susceptibility of murine primary T-lymphocytes to retroviral infection?
Answer: We establish conditions that enable efficient retroviral-mediated gene transfer in murine primary T-lymphocytes. T-lymphocytes are not uniformly susceptible to retroviral infection depending on the mode of T-cell activation. These findings have implications for devising approaches to the study of T-cell biology, adoptive cell therapies, and the pathophysiology of retroviral diseases in mouse models.
Output (English): yes