Task: Answer Verification
Input (English): Question: Does glucocorticoid receptor coordinate transcription factor-dominated regulatory network in macrophages?
Answer: Pro- and anti-inflammatory stimuli alter the expression of a vast array of transcription factors and chromatin remodelers. By regulating multiple transcription factors, which propagate the initial hormonal signal, GR acts as a coordinating hub in anti-inflammatory responses. As several KLFs promote the anti-inflammatory program in macrophages, we propose that GR and KLFs functionally cooperate to curb inflammation.
Output (English): yes