Task: Answer Verification
Input (English): Question: Does up-regulation of FOXM1 by E6 oncoprotein through the MZF1/NKX2-1 axis is require for human papillomavirus-associated tumorigenesis?
Answer: Induction of FOXM1 by E6 oncoprotein through the MZF1/NKX2-1 axis may be responsible for HPV 16/18-mediated tumor progression and poor outcomes in HPV-positive patients.
Output (English): yes