Task: Answer Verification
Input (English): Question: Does topiramate affect the acquisition or expression of ethanol conditioned place preference in DBA/2J or C57BL/6J mice?
Answer: These findings indicate that topiramate has no effect on ethanol's rewarding or conditioned rewarding effects as indexed by the place conditioning procedure. Thus, these studies raise the possibility that topiramate's efficacy in the treatment of alcoholism results from its impact on brain areas other than those that mediate ethanol's rewarding or conditioned rewarding effects. One alternative possibility is that topiramate decreases withdrawal-induced negative affective states that normally contribute to relapse.
Output (English): no