Task: Answer Verification
Input (English): Question: Does melatonin Receptor 1-Deficiency affect Feeding Dynamics and Pro-Opiomelanocortin Expression in the Arcuate Nucleus and Pituitary of Mice?
Answer: Thus, the MT1-mediated signaling stimulates Pomc expression in a region-specific pattern. Since the MT1 mediated changes in Pomc expression do not elicit direct orexigenic or anorexigenic effects such effects are obviously mediated by regulatory systems downstream of the POMC mRNA (e.g. cleavage and release of pro-opiomelanocortin derivatives) which are independent of MT1 signaling.
Output (English): yes