Task: Answer Verification
Input (English): Question: Does rescue therapy with tacrolimus and mycophenolate mofetil prevent deterioration of graft function in C4d-positive chronic allograft nephropathy?
Answer: Our data argue against the efficacy of tacrolimus/mycophenolate mofetil rescue therapy in established C4d-positive chronic allograft dysfunction. Prospective trials are needed to evaluate whether early initiation of this or other antihumoral strategies are capable of effectively preventing alloantibody-mediated chronic graft injury.
Output (English): no