Task: Answer Verification
Input (English): Question: Does decreased Soluble Guanylate Cyclase contribute to Cardiac Dysfunction Induced by Chronic Doxorubicin Treatment in Mice?
Answer: These data demonstrate that a reduction in cardiac sGC activity worsens doxorubicin-induced cardiotoxicity in mice and identify sGC as a potential therapeutic target. Various pharmacological sGC agonists are in clinical development or use and may represent a promising approach to limit doxorubicin-associated cardiotoxicity. Antioxid. Redox Signal. 00, 000-000.
Output (English): yes