Task: Answer Verification
Input (English): Question: Does protein Never in Mitosis Gene A Interacting-1 regulate calpain activity and the degradation of cyclooxygenase-2 in endothelial cells?
Answer: PIN1 reduced calpain activity and slowed the degradation of COX-2 in MAEC, an effect recapitulated by an inhibitor of calpain. Given the sensitivity of COX-2 and iNOS to calpain, PIN1 may normally limit induction of these and other calpain substrates by maintaining calpain activity in endothelial cells.
Output (English): yes