Task: Answer Verification
Input (English): Question: Does vHL genetic alteration in CCRCC determine de-regulation of HIF , CAIX , hnRNP A2/B1 and osteopontin?
Answer: As expression of these proposed pVHL targets can be achieved independently of VHL mutation (and possibly by hypoxia alone), these data suggests that other pVHL targets may be more crucial in renal carcinogenesis.
Output (English): no