Task: Answer Verification
Input (English): Question: Does protamine affect the formation of cGMP or cAMP in pig vascular smooth muscle cells in response to vasodilators?
Answer: These experiments show that protamine does not alter the responses of the intracellular second messengers, cGMP and cAMP, to the vasodilators sodium nitroprusside, atrial natriuretic peptide, isoproterenol, and forskolin. These results do not support the hypothesis that protamine sensitizes vascular smooth muscle cells to the endothelium-derived relaxing factor, nitric oxide.
Output (English): no