Task: Answer Verification
Input (English): Question: Does metformin ameliorate insulin resistance in L6 rat skeletal muscle cells through upregulation of SIRT3?
Answer: Upregulated SIRT3 is involved in the pharmacological mechanism by which metformin promotes glucose uptake. Additionally, SIRT3 may function as an important regulator of oxidative stress and a new alternative approach for targeting insulin resistance-related diseases.
Output (English): yes