Task: Answer Verification
Input (English): Question: Does fasting protect liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice?
Answer: Fasting for one day protects from hepatic IR injury via Sirt1-dependent downregulation of circulating HMGB1. The reduction in serum HMGB1 appears to be mediated by its engagement in the autophagic response. These findings integrate Sirt1, HMGB1, and autophagy into a common framework that underlies the anti-inflammatory properties of short-term fasting.
Output (English): yes