Task: Answer Verification
Input (English): Question: Are hLA-DR and HLA-DQ markers for rapid disease progression in primary sclerosing cholangitis?
Answer: The HLA-associated genetic susceptibility to PSC cannot be attributed to specific amino acid positions of the DR beta chains. The highly discrepant results obtained in two previously reported studies and the present investigation indicate that HLA class II alleles are not markers for a more aggressive clinical course in PSC.
Output (English): no