Task: Answer Verification
Input (English): Question: Are promoter methylation and large intragenic rearrangements of DPYD implicated in severe toxicity to 5-fluorouracil-based chemotherapy in gastrointestinal cancer patients?
Answer: Our results indicate that DPYD promoter methylation and large intragenic rearrangements do not contribute significantly to the development of 5-FU severe toxicity in gastrointestinal cancer patients, supporting the need for additional studies on the mechanisms underlying genetic susceptibility to severe 5-FU toxicity.
Output (English): no