Task: Answer Verification
Input (English): Question: Does choice of non-inferiority ( NI ) margins protect against degradation of treatment effects on an average -- an observational study of registered and published NI trials?
Answer: Only two fifths of the current NI trials had a likelihood of degradation lower than 50%, suggesting that, in majority of the NI trials, there is no sufficient protection against degradation on an average. We suggest a third hurdle for the choice of NI margins, thus contributing a sufficient degree of protection.
Output (English): no