Task: Answer Verification
Input (English): Question: Is a novel BHLHE41 variant associated with short sleep and resistance to sleep deprivation in humans?
Answer: There are a number of mutations of BHLHE41. Mutations reduce total sleep while maintaining NREM sleep and provide resistance to the effects of sleep loss. Mutations that affect sleep also modify the normal inhibition of BHLHE41 of CLOCK/BMAL1 transactivation. Thus, clock mechanisms are likely involved in setting sleep length and the magnitude of sleep homeostasis.
Output (English): yes