Task: Answer Verification
Input (English): Question: Does neoadjuvant chemotherapy for osteosarcoma of the extremity : intensification of preoperative treatment increase the rate of good histologic response to the primary tumor or improve the final outcome?
Answer: Increasing the doses of preoperative chemotherapy does not improve the rate of good histologic response and survival in osteosarcoma of the extremity. The degree of necrosis induced by preoperative treatment probably reflects an innate sensitivity to chemotherapy, which is not altered by increasing drug doses.
Output (English): no