Task: Answer Verification
Input (English): Question: Does mechanotransduction in bone require a functional cyclooxygenase-2 ( COX-2 ) gene?
Answer: A functional COX-2 gene was not found to be required for skeletal mechanotransduction. This is in contrast to previous pharmacological studies showing that COX-2 is critical to the response of bone to loading. Investigating a potential reason for the absence of a genotype difference in this study, we found that mice with a null mutation in the COX-2 gene possess inductive skeletal COX-1 expression.
Output (English): no