Task: Answer Verification
Input (English): Question: Are plasma serotonin and histamine levels in hemodialysis-related pruritus significantly influenced by 5-HT3 receptor blocker and antihistaminic therapy?
Answer: Histamine and serotonin are no major mediators of pruritus in hemodialysis patients. Elevated histamine levels are occassionally seen and may be due to the increased mast cell number found in a subgroup of hemodialysis patients. Our findings explain the only marginal relief of antihistamines and the controversial antipruritic effect of serotonin receptor antagonists in hemodialysis-related pruritus.
Output (English): no