Task: Answer Verification
Input (English): Question: Is bone mineral content in patients with congenital generalized lipodystrophy unaffected by metreleptin replacement therapy?
Answer: In contrast to rodent models, CGL patients have increased BMC in the leptin-deficient state, which does not change with leptin replacement. The high BMC in these patients is partially explained by high lean mass and tall stature.
Output (English): yes