Task: Answer Verification
Input (English): Question: Does methylglyoxal impair endothelial insulin sensitivity both in vitro and in vivo?
Answer: MGO impairs the action of insulin on the endothelium both in vitro and in vivo, at least in part through an ERK1/2-mediated mechanism. These findings may be instrumental in developing novel strategies for preserving endothelial function in diabetes.
Output (English): yes