Task: Answer Verification
Input (English): Question: Is aortic vasoconstriction related to smooth muscle cells ET-A and ET-B receptors involved in hypoxia-induced sustained systemic arterial hypertension in rats?
Answer: This work clearly suggests that, following long term exposure to hypoxia, ET-1 and ET-1 receptors are not involved in the persistence of systemic hypertension in a rat model, and that chronic exposure to severe hypoxic stress was associated with a downregulation of the ET-A receptors response to ET-1.
Output (English): no