Task: Answer Verification
Input (English): Question: Is gng12 a novel negative regulator of LPS-induced inflammation in the microglial cell line BV-2?
Answer: Modulating Gng12 mRNA levels using RNAi revealed a novel role for the factor in the negative regulation of the overall inflammatory response as based on effects on nitrite and TNFalpha levels. These data suggest that Gng12 is a negative regulator of the LPS response and may be an important factor in the overall inflammatory signaling cascade.
Output (English): yes