Task: Answer Verification
Input (English): Question: Is arecoline cytotoxic for human endothelial cells?
Answer: Arecoline is cytotoxic via necrosis for endothelium, while biochemical assays indicate no appreciable cellular leakage before death and detachment, as well as no clear effect on mitochondrial function in viable cells. Arecoline toxicity may thus contribute to reduced vascularity in oral submucous fibrosis.
Output (English): yes