Task: Answer Verification
Input (English): Question: Is cYP2D6 polymorphism crucial for the disposition of selegiline?
Answer: CYP2D6 is not important in the primary elimination of selegiline, and the biological effect of selegiline seems to be similar in poor metabolizers and extensive metabolizers of debrisoquin. The inhibitory effect of selegiline and its main metabolites on CYP2D6 activity seems to be negligible.
Output (English): no