Task: Answer Verification
Input (English): Question: Does tLR4 activation induce IL-1β release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung?
Answer: TLR4 activation increases levels of BALF IL-1b/IL-18 via an IPAF dependent and caspase 1/11/8 independent pathway. Furthermore, it would appear that the presence of IL-1a in the BALF is independent of these pathways. This novel data sheds light on innate signalling pathways in the lung that control the production of these key inflammatory cytokines.
Output (English): yes