Task: Answer Verification
Input (English): Question: Does measurement of refractive index by nanoparticle tracking analysis reveal heterogeneity in extracellular vesicles?
Answer: Using NTA and Mie scattering theory, we have demonstrated that it is possible to estimate the RI of sub-micron EV using NTA data. EV typically had a modal RI of 1.37-1.39, whereas values of >1.40 were observed for some large (>200 nm) microvesicles.
Output (English): yes