Task: Answer Verification
Input (English): Question: Does increased proteoglycan synthesis in cartilage in experimental canine osteoarthritis reflect a permanent change in chondrocyte phenotype?
Answer: Previous results indicated that PG synthesis and turnover in articular cartilage was increased for many months after induction of experimental OA. Our present results show that the enhanced rate of PG synthesis and turnover were evident in freshly explanted tissue, but the differences were lost over 3 days in culture. A decreased responsiveness to TNF alpha was also lost. The hypermetabolic activity of experimental OA chondrocytes was thus reversible and not a permanent change in chondrocyte phenotype.
Output (English): no