Task: Answer Verification
Input (English): Question: Does thymidylate synthase mRNA expression predict resistance to floxuridine in a choriocarcinoma cell line?
Answer: We successfully established an FUDR-resistant human choriocarcinoma sub-line and found that the expression of TS mRNA in FUDR-resistant JeG-3 cells was related to the concentration and phase of FUDR exposure. These data suggest that TS mRNA levels would be of limited use as biomarkers for the prediction of chemoresistance to FUDR-based chemotherapy.
Output (English): no