Task: Answer Verification
Input (English): Question: Does silence of MCL-1 upstream signaling by shRNA abrogate multiple myeloma growth?
Answer: There is a syngeneic effect among the three independent STAT3, PI3K and MAPK2 survival-signaling pathways related to MCL-1 expression in MM cells. shRNAs silencing of STAT3, PI3K and MAPK2 together could provide an effective strategy to treat MM.
Output (English): yes