Naloxone [SEP] Naloxone reverses the antihypertensive effect of clonidine.

Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto


clonidine [SEP] Naloxone reverses the antihypertensive effect of clonidine.

Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl


hypertensive [SEP] In unanesthetized, spontaneously hypertensive rats the decrease in blood pressure and heart rate produced by

Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c


clonidine [SEP] crease in blood pressure and heart rate produced by intravenous clonidine, 5 to 20 micrograms/kg, was inhibited or reversed by nalozone,


hypotensive [SEP] /kg, was inhibited or reversed by nalozone, 0.2 to 2 mg/kg. The hypotensive effect of 100 mg/kg alpha-methyldopa was also partially reverse

Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI


alpha-methyldopa [SEP] y nalozone, 0.2 to 2 mg/kg. The hypotensive effect of 100 mg/kg alpha-methyldopa was also partially reversed by naloxone. Naloxone alone did not

Methyldopa [SEP] An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an ant


naloxone [SEP] ct of 100 mg/kg alpha-methyldopa was also partially reversed by naloxone. Naloxone alone did not affect either blood pressure or heart r


Naloxone [SEP] mg/kg alpha-methyldopa was also partially reversed by naloxone. Naloxone alone did not affect either blood pressure or heart rate. In br


Lidocaine [SEP] Lidocaine-induced cardiac asystole.

Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro


cardiac asystole [SEP] Lidocaine-induced cardiac asystole.

Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c


lidocaine [SEP] Intravenous administration of a single 50-mg bolus of lidocaine in a 67-year-old man resulted in profound depression of the act


depression [SEP] mg bolus of lidocaine in a 67-year-old man resulted in profound depression of the activity of the sinoatrial and atrioventricular nodal pa

Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur


bradyarrhythmias [SEP] nditions which might have predisposed him to the development of bradyarrhythmias; and, thus, this probably represented a true idiosyncrasy to li

Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th


Suxamethonium [SEP] Suxamethonium infusion rate and observed fasciculations. A dose-response stud

Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan


fasciculations [SEP] Suxamethonium infusion rate and observed fasciculations. A dose-response study.

Fasciculation [SEP] Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations can often by visualized and take the for


Suxamethonium chloride [SEP] Suxamethonium chloride (Sch) was administered i.v. to 36 adult males at six rates: 0.2


Sch [SEP] Suxamethonium chloride (Sch) was administered i.v. to 36 adult males at six rates: 0.25 mg


tetanic [SEP]  was discontinued either when there was no muscular response to tetanic stimulation of the ulnar nerve or when Sch 120 mg was exceeded.

Tetany [SEP] A disorder characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures. This cond


Fasciculations [SEP] eded. Six additional patients received a 30-mg i.v. bolus dose. Fasciculations in six areas of the body were scored from 0 to 3 and summated a


fasciculation [SEP] eas of the body were scored from 0 to 3 and summated as a total fasciculation score. The times to first fasciculation, twitch suppression and


twitch [SEP]  a total fasciculation score. The times to first fasciculation, twitch suppression and tetanus suppression were inversely related to t


tetanus [SEP] score. The times to first fasciculation, twitch suppression and tetanus suppression were inversely related to the infusion rates. Fasci


Galanthamine hydrobromide [SEP] Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of t

Galantamine [SEP] A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor tha


scopolamine [SEP] cholinesterase drug, in the treatment of the central effects of scopolamine (Hyoscine).

Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l


Hyoscine [SEP] e drug, in the treatment of the central effects of scopolamine (Hyoscine).


Galanthamine hydrobromide [SEP] Galanthamine hydrobromide, an anticholinesterase drug capable of penetrating the blood-br


scopolamine [SEP] barrier, was used in a patient demonstrating central effects of scopolamine (hyoscine) overdosage. It is longer acting than physostigmine a


hyoscine [SEP] used in a patient demonstrating central effects of scopolamine (hyoscine) overdosage. It is longer acting than physostigmine and is used


overdosage [SEP] patient demonstrating central effects of scopolamine (hyoscine) overdosage. It is longer acting than physostigmine and is used in anaesthe

Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.


physostigmine [SEP]  of scopolamine (hyoscine) overdosage. It is longer acting than physostigmine and is used in anaesthesia to reverse the non-depolarizing neur

Physostigmine [SEP] A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also c


lithium [SEP] Effects of uninephrectomy and high protein feeding on lithium-induced chronic renal failure in rats.

Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of


chronic renal failure [SEP] s of uninephrectomy and high protein feeding on lithium-induced chronic renal failure in rats.

Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l


lithium [SEP] Rats with lithium-induced nephropathy were subjected to high protein (HP) feeding


nephropathy [SEP] Rats with lithium-induced nephropathy were subjected to high protein (HP) feeding, uninephrectomy (NX

Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.


renal failure [SEP] to induce glomerular hyperfiltration and further progression of renal failure. Newborn female Wistar rats were fed a lithium-containing diet

Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain


Li [SEP] sed a fall in filtration fraction and an increase in fractional Li excretion. Lithium also caused proteinuria and systolic hyperte


Lithium [SEP] filtration fraction and an increase in fractional Li excretion. Lithium also caused proteinuria and systolic hypertension in absence of


proteinuria [SEP] and an increase in fractional Li excretion. Lithium also caused proteinuria and systolic hypertension in absence of glomerulosclerosis. HP

Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.


hypertension [SEP] onal Li excretion. Lithium also caused proteinuria and systolic hypertension in absence of glomerulosclerosis. HP failed to accentuante prog

Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c


glomerulosclerosis [SEP] also caused proteinuria and systolic hypertension in absence of glomerulosclerosis. HP failed to accentuante progression of renal failure and in f

Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti


creatinine [SEP]  failure and in fact tended to increase GFR and decrease plasma creatinine levels in lithium pretreated rats. NX caused an additive deteri

Creatinine [SEP]


chronic renal failure [SEP] roteinuria and arterial systolic hypertension. In this model of chronic renal failure the decline in GFR is not accompanied by a corresponding fall i


Crohn's disease [SEP] Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive propert

Crohn Disease [SEP] A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM


fusidic acid [SEP] Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyc

Fusidic Acid [SEP] An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting tra


cyclosporin [SEP] cid: an antibiotic with immunosuppressive properties similar to cyclosporin.

Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.


cyclosporin [SEP] h T-cell specific immunosuppressive effects similar to those of cyclosporin. Because of the need for the development of new treatments for


Crohn's disease [SEP] . Because of the need for the development of new treatments for Crohn's disease, a pilot study was undertaken to estimate the pharmacodynamics


fusidic acid [SEP] undertaken to estimate the pharmacodynamics and tolerability of fusidic acid treatment in chronic active, therapy-resistant patients. Eight


Fusidic acid [SEP] Fusidic acid is an antibiotic with T-cell specific immunosuppressive effects


nausea [SEP] cts, but dose reduction was required in two patients because of nausea. Biochemically, an increase in alkaline phosphatases was noted

Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti


inflammatory bowel disease [SEP]  rationale for the use of fusidic acid at the cytokine level in inflammatory bowel disease, we suggest that the role of this treatment should be further i

Inflammatory Bowel Diseases [SEP] Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes C


myocardial injury [SEP] Electrocardiographic evidence of myocardial injury in psychiatrically hospitalized cocaine abusers.

Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi


cocaine [SEP] c evidence of myocardial injury in psychiatrically hospitalized cocaine abusers.

Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic


cocaine [SEP] The electrocardiograms (ECG) of 99 cocaine-abusing patients were compared with the ECGs of 50 schizophreni


schizophrenic [SEP] f 99 cocaine-abusing patients were compared with the ECGs of 50 schizophrenic controls. Eleven of the cocaine abusers and none of the control

Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL


myocardial injury [SEP] busers and none of the controls had ECG evidence of significant myocardial injury defined as myocardial infarction, ischemia, and bundle branch b


myocardial infarction [SEP] ls had ECG evidence of significant myocardial injury defined as myocardial infarction, ischemia, and bundle branch block.

Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).


ischemia [SEP] significant myocardial injury defined as myocardial infarction, ischemia, and bundle branch block.

Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,


bundle branch block [SEP] ocardial injury defined as myocardial infarction, ischemia, and bundle branch block.

Bundle-Branch Block [SEP] A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BU


Sulpiride [SEP] Sulpiride-induced tardive dystonia.

Sulpiride [SEP] A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.


tardive dystonia [SEP] Sulpiride-induced tardive dystonia.

Dystonia [SEP] An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often aff


Sulpiride [SEP] Sulpiride is a selective D2-receptor antagonist with antipsychotic and an


antidepressant [SEP] de is a selective D2-receptor antagonist with antipsychotic and antidepressant properties. Although initially thought to be free of extrapyram

Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE


sulpiride [SEP] gh initially thought to be free of extrapyramidal side effects, sulpiride-induced tardive dyskinesia and parkinsonism have been reported


tardive dyskinesia [SEP] ht to be free of extrapyramidal side effects, sulpiride-induced tardive dyskinesia and parkinsonism have been reported occasionally. We studied a

Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or


parkinsonism [SEP] yramidal side effects, sulpiride-induced tardive dyskinesia and parkinsonism have been reported occasionally. We studied a 37-year-old man w

Parkinson Disease, Secondary [SEP] Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected co


dystonia [SEP] We studied a 37-year-old man who developed persistent segmental dystonia within 2 months after starting sulpiride therapy. We could not


tardive dystonia [SEP] py. We could not find any previous reports of sulpiride-induced tardive dystonia.


auditory toxicity [SEP] Ocular and auditory toxicity in hemodialyzed patients receiving desferrioxamine.

Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,


desferrioxamine [SEP] Ocular and auditory toxicity in hemodialyzed patients receiving desferrioxamine.

Deferoxamine [SEP] Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in th


desferrioxamine [SEP]  an 18-month period of study 41 hemodialyzed patients receiving desferrioxamine (10-40 mg/kg BW/3 times weekly) for the first time were monitor


auditory toxicity [SEP] l toxicity. 6 patients presented clinical symptoms of visual or auditory toxicity. Moreover, detailed ophthalmologic and audiologic studies discl


Visual toxicity [SEP] tudies disclosed abnormalities in 7 more asymptomatic patients. Visual toxicity was of retinal origin and was characterized by a tritan-type dy

Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri


a loss of visual acuity [SEP] ized by a tritan-type dyschromatopsy, sometimes associated with a loss of visual acuity and pigmentary retinal deposits. Auditory toxicity was characte


pigmentary retinal deposits [SEP] omatopsy, sometimes associated with a loss of visual acuity and pigmentary retinal deposits. Auditory toxicity was characterized by a mid- to high-frequenc

Retinal Diseases [SEP]


Auditory toxicity [SEP] d with a loss of visual acuity and pigmentary retinal deposits. Auditory toxicity was characterized by a mid- to high-frequency neurosensorial he


neurosensorial hearing loss [SEP] Auditory toxicity was characterized by a mid- to high-frequency neurosensorial hearing loss and the lesion was of the cochlear type. Desferrioxamine withdr

Hearing Loss, Sensorineural [SEP] Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round


Desferrioxamine [SEP] sensorial hearing loss and the lesion was of the cochlear type. Desferrioxamine withdrawal resulted in a complete recovery of visual function i


hearing loss [SEP] ty was characterized by a mid- to high-frequency neurosensorial hearing loss and the lesion was of the cochlear type. Desferrioxamine withdr

Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.


toxicity [SEP]  for the first time were monitored for detection of audiovisual toxicity. 6 patients presented clinical symptoms of visual or auditory t

Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem


Myasthenia gravis [SEP] Myasthenia gravis presenting as weakness after magnesium administration.

Myasthenia Gravis [SEP] A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed agai


magnesium [SEP] Myasthenia gravis presenting as weakness after magnesium administration.

Magnesium [SEP] A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of


neuromuscular disease [SEP] We studied a patient with no prior history of neuromuscular disease who became virtually quadriplegic after parenteral magnesium ad

Neuromuscular Diseases [SEP] A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manif


quadriplegic [SEP]  no prior history of neuromuscular disease who became virtually quadriplegic after parenteral magnesium administration for preeclampsia. The

Quadriplegia [SEP] Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHER


magnesium [SEP] ular disease who became virtually quadriplegic after parenteral magnesium administration for preeclampsia. The serum magnesium concentrat


preeclampsia [SEP] ally quadriplegic after parenteral magnesium administration for preeclampsia. The serum magnesium concentration was 3.0 mEq/L, which is usua

Pre-Eclampsia [SEP] A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or with


postsynaptic neuromuscular blockade [SEP] icant facilitation at rapid rates or after exercise, suggesting postsynaptic neuromuscular blockade. After her strength returned, repetitive stimulation was normal


acetylcholine [SEP] ut single fiber EMG revealed increased jitter and blocking. Her acetylcholine receptor antibody level was markedly elevated. Although paralys

Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe


paralysis [SEP] choline receptor antibody level was markedly elevated. Although paralysis after magnesium administration has been described in patients w

Paralysis [SEP] A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level


myasthenia gravis [SEP] nesium administration has been described in patients with known myasthenia gravis, it has not previously been reported to be the initial or only


disorder of neuromuscular transmission [SEP] ffects of magnesium should be suspected of having an underlying disorder of neuromuscular transmission.

Neuromuscular Junction Diseases [SEP] Conditions characterized by impaired transmission of impulses at the NEUROMUSCULAR JUNCTION. This may result from disorders that


Chloroacetaldehyde [SEP] Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclo

chloroacetaldehyde [SEP]


cyclophosphamide [SEP] ehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication.

Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo


ifosfamide [SEP] bution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication.

Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.


chloroacetaldehyde [SEP] Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatic

chloroacetaldehyde [SEP]


CAA [SEP] Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatics, an

chloroacetaldehyde [SEP]


hemorrhagic [SEP] out in order to elucidate the role of CAA in the development of hemorrhagic cystitis. The data demonstrate that CAA after i.v. administrati

Hemorrhage [SEP] Bleeding or escape of blood from a vessel.


cystitis [SEP]  to elucidate the role of CAA in the development of hemorrhagic cystitis. The data demonstrate that CAA after i.v. administration does n

Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful


bladder damage [SEP] trate that CAA after i.v. administration does not contribute to bladder damage. When instilled directly into the bladder, CAA exerts urotoxic

Urinary Bladder Diseases [SEP] Pathological processes of the URINARY BLADDER.


mesna [SEP] xic effects, it is, however, susceptible to detoxification with mesna.

Mesna [SEP] A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFA


pain [SEP] Source of pain and primitive dysfunction in migraine: an identical site?

Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.


migraine [SEP] Source of pain and primitive dysfunction in migraine: an identical site?

Migraine Disorders [SEP] A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtyp


migraine [SEP] Twenty common migraine patients received a one sided frontotemporal application of nit


nitroglycerin [SEP] ine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double bli

Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als


pain [SEP] n seems to depend on direct stimulation of the habitual site of pain, suggesting that the frontotemporal region is of crucial import


Clotiazepam [SEP] Clotiazepam-induced acute hepatitis.

clotiazepam [SEP]


hepatitis [SEP] Clotiazepam-induced acute hepatitis.

Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug


hepatitis [SEP] We report the case of a patient who developed acute hepatitis with extensive hepatocellular necrosis, 7 months after the onse


extensive hepatocellular necrosis [SEP] report the case of a patient who developed acute hepatitis with extensive hepatocellular necrosis, 7 months after the onset of administration of clotiazepam, a t

Massive Hepatic Necrosis [SEP] Extensive and rapid death of parenchymal cells in the LIVER, often due to exposure to toxic materials. It is characterized by a


clotiazepam [SEP] ellular necrosis, 7 months after the onset of administration of clotiazepam, a thienodiazepine derivative. Clotiazepam withdrawal was follo

clotiazepam [SEP]


thienodiazepine [SEP] s, 7 months after the onset of administration of clotiazepam, a thienodiazepine derivative. Clotiazepam withdrawal was followed by prompt recov

thienodiazepine substance [SEP]


Clotiazepam [SEP] of administration of clotiazepam, a thienodiazepine derivative. Clotiazepam withdrawal was followed by prompt recovery. The administration

clotiazepam [SEP]


benzodiazepines [SEP]  was followed by prompt recovery. The administration of several benzodiazepines, chemically related to clotiazepam, did not interfere with reco

Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.


hepatotoxicity [SEP]  can induce acute hepatitis and suggests that there is no cross hepatotoxicity between clotiazepam and several benzodiazepines.


hypertension [SEP] Arterial hypertension as a complication of prolonged ketoconazole treatment.

Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c


ketoconazole [SEP] Arterial hypertension as a complication of prolonged ketoconazole treatment.

Ketoconazole [SEP] Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.


Cushing's syndrome [SEP] Two of 14 patients with Cushing's syndrome treated on a long-term basis with ketoconazole developed sustai

Cushing Syndrome [SEP] A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous


ketoconazole [SEP] ients with Cushing's syndrome treated on a long-term basis with ketoconazole developed sustained hypertension. In both cases normal plasma a


hypertension [SEP] ated on a long-term basis with ketoconazole developed sustained hypertension. In both cases normal plasma and urinary free cortisol levels h


cortisol [SEP] ined hypertension. In both cases normal plasma and urinary free cortisol levels had been achieved following ketoconazole therapy, yet co

Hydrocortisone [SEP] The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically,


deoxycorticosterone [SEP] eks (patient 2) after treatment. In patient 1, plasma levels of deoxycorticosterone and 11-deoxycortisol were elevated. In patient 2, in addition t

Desoxycorticosterone [SEP] A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE


11-deoxycortisol [SEP] eatment. In patient 1, plasma levels of deoxycorticosterone and 11-deoxycortisol were elevated. In patient 2, in addition to an increase in both

Cortodoxone [SEP] 17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.


aldosterone [SEP] in both deoxycorticosterone and 11-deoxycortisol levels, plasma aldosterone values were raised, with a concomitant suppression of renin lev

Aldosterone [SEP] A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodiu


angiotensin [SEP] Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficie

Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG


Captopril [SEP] Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coag

Captopril [SEP] A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoco


renal insufficiency [SEP] r of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat.

Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain


intravascular coagulation [SEP]  enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat.

Disseminated Intravascular Coagulation [SEP] A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The


intravascular coagulation [SEP] Induction of intravascular coagulation and inhibition of fibrinolysis by injection of thrombin and tra


tranexamic acid [SEP] ion and inhibition of fibrinolysis by injection of thrombin and tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal insufficien

Tranexamic Acid [SEP] Antifibrinolytic hemostatic used in severe hemorrhage.


AMCA [SEP] n of fibrinolysis by injection of thrombin and tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal insufficiency res


renal insufficiency [SEP] d tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal insufficiency resembling that occurring after trauma or sepsis in man. Inject


trauma [SEP] lmonary and renal insufficiency resembling that occurring after trauma or sepsis in man. Injection of Captopril (1 mg/kg), an inhibito

Wounds and Injuries [SEP] Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural con


sepsis [SEP] d renal insufficiency resembling that occurring after trauma or sepsis in man. Injection of Captopril (1 mg/kg), an inhibitor of angio

Sepsis [SEP] Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dys


Captopril [SEP] ling that occurring after trauma or sepsis in man. Injection of Captopril (1 mg/kg), an inhibitor of angiotensin converting enzyme (ACE),


angiotensin [SEP] epsis in man. Injection of Captopril (1 mg/kg), an inhibitor of angiotensin converting enzyme (ACE), reduced both pulmonary and renal insuf


Renal damage [SEP]  that Captopril did not influence the extravasation of protein. Renal damage as reflected by an increase in serum urea and in kidney weight

Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.


urea [SEP] n of protein. Renal damage as reflected by an increase in serum urea and in kidney weight was prevented by Captopril. The amount of

Urea [SEP] A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of prote


Angiotension II [SEP] odilatory effect due to a reduction in the circulating level of Angiotension II and an increase in prostacyclin (secondary to an increase in br

Angiotensin II [SEP] An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino aci


prostacyclin [SEP]  in the circulating level of Angiotension II and an increase in prostacyclin (secondary to an increase in bradykinin). Captopril may, by the

Epoprostenol [SEP] A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTA


bradykinin [SEP] II and an increase in prostacyclin (secondary to an increase in bradykinin). Captopril may, by the same mechanism, reduce the increase in

Bradykinin [SEP] A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of


kidney damage [SEP] ith the result that less fibrin will be deposited and thus less kidney damage will be produced.


labetalol [SEP] A randomized comparison of labetalol and nitroprusside for induced hypotension.

Labetalol [SEP] A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.


nitroprusside [SEP] A randomized comparison of labetalol and nitroprusside for induced hypotension.

Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f


hypotension [SEP] andomized comparison of labetalol and nitroprusside for induced hypotension.

Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI


labetalol [SEP] In a randomized study, labetalol-induced hypotension and nitroprusside-induced hypotension were


hypotension [SEP] In a randomized study, labetalol-induced hypotension and nitroprusside-induced hypotension were compared in 20 patie


nitroprusside [SEP] In a randomized study, labetalol-induced hypotension and nitroprusside-induced hypotension were compared in 20 patients (10 in each gr


reductions in mean arterial blood pressure [SEP] ed to an identical anesthetic protocol and similar drug-induced reductions in mean arterial blood pressure (BP) (50 to 55 mmHg). Nitroprusside infusion was associated wit


increase in heart rate and cardiac output [SEP] e infusion was associated with a significant (p less than 0.05) increase in heart rate and cardiac output; rebound hypertension was observed in three patients after disc

Cardiac Output, High [SEP] A state of elevated cardiac output due to conditions of either increased hemodynamic demand or reduced cardiac oxygen output. Th


hypertension [SEP] s than 0.05) increase in heart rate and cardiac output; rebound hypertension was observed in three patients after discontinuation of nitropr

Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c


Labetalol [SEP] erved in three patients after discontinuation of nitroprusside. Labetalol administration was not associated with any of these findings. A


PO2 [SEP] tration was not associated with any of these findings. Arterial PO2 decreased in both groups. It was concluded that labetalol offer

PO-2 [SEP]


carbamazepine [SEP] Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma

Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s


toxicity [SEP] Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations.

Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem


folate [SEP] in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations.

Folic Acid [SEP] A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in


Folate [SEP] Folate depletion has often been a problem in chronic antiepileptic dru


Carbamazepine [SEP] ten been a problem in chronic antiepileptic drug (AED) therapy. Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinica


CBZ [SEP] lem in chronic antiepileptic drug (AED) therapy. Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinical stu


folate [SEP] as developed to examine the effects of chronic CBZ treatment on folate concentrations in the rat. In the course of developing this mod


propylene glycol [SEP]  rat. In the course of developing this model, a common vehicle, propylene glycol, by itself in high doses, was found to exhibit protective prope

Propylene Glycol [SEP] A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.


seizures [SEP] ses, was found to exhibit protective properties against induced seizures and inhibited weight gain. Seizures induced by hexafluorodiethy

Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br


weight gain [SEP] it protective properties against induced seizures and inhibited weight gain. Seizures induced by hexafluorodiethyl ether (HFDE) were also f

Weight Gain [SEP] Increase in BODY WEIGHT over existing weight.


Seizures [SEP]  properties against induced seizures and inhibited weight gain. Seizures induced by hexafluorodiethyl ether (HFDE) were also found to be


hexafluorodiethyl ether [SEP] induced seizures and inhibited weight gain. Seizures induced by hexafluorodiethyl ether (HFDE) were also found to be a more sensitive measure of protec

Flurothyl [SEP] A convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock


HFDE [SEP] bited weight gain. Seizures induced by hexafluorodiethyl ether (HFDE) were also found to be a more sensitive measure of protection b


sodium [SEP] In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq/kg/day, sympathetic activity was assessed

Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.


norepinephrine [SEP] g/day, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15-minute i.v. infusions of human alpha-

Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor


epinephrine [SEP] ay, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15-minute i.v. infusions of human alpha-

Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes


tachycardia [SEP] n 0.01), or 79 +/- 6% (p less than 0.001), respectively, but no tachycardia and no augmentation of the norepinephrine release rate (up to 0

Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba


hypotension [SEP] ogram/kg/min) were observed, which is in contrast to comparable hypotension induced by hydralazine or nitroglycerin. The release rate of ep


hydralazine [SEP] rved, which is in contrast to comparable hypotension induced by hydralazine or nitroglycerin. The release rate of epinephrine (control, 6.7

Hydralazine [SEP] A direct-acting vasodilator that is used as an antihypertensive agent.


nitroglycerin [SEP] in contrast to comparable hypotension induced by hydralazine or nitroglycerin. The release rate of epinephrine (control, 6.7 +/- 0.6 ng/kg/mi

Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als


Death [SEP] Death from chemotherapy in gestational trophoblastic disease.

Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular


gestational trophoblastic disease [SEP] Death from chemotherapy in gestational trophoblastic disease.

Gestational Trophoblastic Disease [SEP] A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and marke


choriocarcinoma [SEP] erally accepted treatment of patients with a high-risk stage of choriocarcinoma. Based on this principle a 27-year old woman, classified as bei

Choriocarcinoma [SEP] A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI b


Etoposide [SEP] ultiple cytotoxic drugs. The multiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cispla

Etoposide [SEP] A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a co


Methotrexate [SEP] drugs. The multiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin. On the first day

Methotrexate [SEP] An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and pre


Cyclophosphamide [SEP] tiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin. On the first day of the schedule,

Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo


Actomycin-D [SEP] consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin. On the first day of the schedule, moderate high

Dactinomycin [SEP] A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to


Cisplatin [SEP] poside 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin. On the first day of the schedule, moderate high doses of Metho

Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter


pulmonary obstruction [SEP] apy the patient died with a clinical picture resembling massive pulmonary obstruction due to choriocarcinomic tissue plugs, probably originating from

Pulmonary Embolism [SEP] Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.


tumor [SEP]  uterus. Formation of these plugs was probably due to extensive tumor necrosis at the level of the walls of the major uterine veins,

Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me


necrosis [SEP] s. Formation of these plugs was probably due to extensive tumor necrosis at the level of the walls of the major uterine veins, which res

Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol


embolism [SEP] etween the start of chemotherapy and the acute onset of massive embolism other explanations, such as spontaneous necrosis, must be consi

Embolism [SEP] Blocking of a blood vessel by an embolus which can be a blood clot or other undissolved material in the blood stream.


pelvic tumor [SEP] s necrosis, must be considered less likely. Patients with large pelvic tumor loads are, according to existing classifications, at high risk

Pelvic Neoplasms [SEP] Tumors or cancer of the pelvic region.


Sexual dysfunction [SEP] Sexual dysfunction among patients with arthritis.

Sexual Dysfunction, Physiological [SEP] Physiological disturbances in normal sexual performance in either the male or the female.


arthritis [SEP] Sexual dysfunction among patients with arthritis.

Arthritis [SEP]


arthritis [SEP] The relationship of arthritis and sexual dysfunction was investigated among 169 patients with

Arthritis [SEP]


sexual dysfunction [SEP] The relationship of arthritis and sexual dysfunction was investigated among 169 patients with rheumatoid arthritis,


rheumatoid arthritis [SEP] and sexual dysfunction was investigated among 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair-

Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru


osteoarthritis [SEP]  was investigated among 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair-matched to contr

Osteoarthritis [SEP] A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is though


spondyloarthropathy [SEP] mong 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair-matched to controls. Assessments of mari

Spondylarthropathies [SEP] Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN


depressed mood [SEP]  pair-matched to controls. Assessments of marital happiness and depressed mood were also made using the CES-D and the Azrin Marital Happiness

Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur


Sexual dysfunctions [SEP] e using the CES-D and the Azrin Marital Happiness Scale (AMHS). Sexual dysfunctions were found to be common among patients and controls, the majori


Impotence [SEP] the majority in both groups reporting one or more dysfunctions. Impotence was more common among male patients than controls and was found

Erectile Dysfunction [SEP] The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.


methotrexate [SEP]  was found to be associated with co-morbidity and the taking of methotrexate. Depressed mood was more common among patients and was associat


Depressed mood [SEP] be associated with co-morbidity and the taking of methotrexate. Depressed mood was more common among patients and was associated with certain


impotence [SEP] d was associated with certain sexual difficulties, but not with impotence. Marital unhappiness, as indicated by AMHS scores, was not asso


paracetamol [SEP] Does paracetamol cause urothelial cancer or renal papillary necrosis?

Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but


urothelial cancer [SEP] Does paracetamol cause urothelial cancer or renal papillary necrosis?

Urethral Neoplasms [SEP] Cancer or tumors of the URETHRA. Benign epithelial tumors of the urethra usually consist of squamous and transitional cells. Pri


renal papillary necrosis [SEP] Does paracetamol cause urothelial cancer or renal papillary necrosis?

Kidney Papillary Necrosis [SEP] A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this ar


renal papillary necrosis [SEP] The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated wit


cancer of the renal pelvis [SEP] The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenac

Kidney Neoplasms [SEP] Tumors or cancers of the KIDNEY.


phenacetin [SEP] pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnai

Phenacetin [SEP] A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the mark


paracetamol [SEP]  or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cas


ureteric cancer [SEP] the risk for cancer of the renal pelvis and bladder but not for ureteric cancer. By contrast, we were unable to substantiate an increased risk

Ureteral Neoplasms [SEP] Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA


cancers [SEP] etamol consumption for renal papillary necrosis or any of these cancers although there was a suggestion of an association with cancer o


cancer of the ureter [SEP]  cancers although there was a suggestion of an association with cancer of the ureter.


Dapsone [SEP] Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman wit

Dapsone [SEP] A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanis


hemolytic anemia [SEP] Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait.

Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl


leprosy [SEP] A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of

Leprosy [SEP] A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the muco


hemolytic anemia [SEP] with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associat


dapsone [SEP]  developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her


hemolysis [SEP] ose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body

Hemolysis [SEP] The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and change


glutathione [SEP] had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH stability. The pentose phosphate shunt

Glutathione [SEP] A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some en


GSH [SEP]  incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH stability. The pentose phosphate shunt acti


pentose phosphate [SEP] sed reduced glutathione (GSH), and decreased GSH stability. The pentose phosphate shunt activity of the dapsone-exposed AE RBCs was increased com

Pentosephosphates [SEP]


infection [SEP] idant medications should be used with caution, especially if an infection is present, in individuals of ethnic backgrounds that have an i

Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.


metoprolol [SEP] l drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine.

Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI


propafenone [SEP] py in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine.

Propafenone [SEP] An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.


diltiazem [SEP] nt identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine.

Diltiazem [SEP] A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.


sparteine [SEP] s a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine.

Sparteine [SEP] A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytoci


coronary artery disease [SEP] A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hyp

Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot


shock [SEP] ffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventr

Shock [SEP] A pathological condition manifested by failure to perfuse or oxygenate vital organs.


AV block [SEP] onary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. On

Atrioventricular Block [SEP] Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduc


hypotension [SEP] ase was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admi

Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI


impairment of ventricular function [SEP] to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of m

Ventricular Dysfunction [SEP] A condition in which HEART VENTRICLES exhibit impaired function.


metoprolol [SEP] n. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two


diltiazem [SEP] en 100 mg b.i.d.) had been initiated. Two days before admission diltiazem (60 mg b.i.d.) was prescribed in addition. Analyses of a blood


propafenone [SEP]  patient was exposed to a single dose of metoprolol, diltiazem, propafenone (since he had received this drug in the past), and sparteine (a


sparteine [SEP]  propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of


debrisoquine [SEP] eived this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism). It w

Debrisoquin [SEP] An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorp


adverse drug reactions [SEP] which constitutes 6.4% of the German population, may experience adverse drug reactions when treated with standard doses of one of these drugs alone. M

Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem


Triazolam [SEP] Triazolam-induced brief episodes of secondary mania in a depressed patien

Triazolam [SEP] A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market b


mania [SEP] Triazolam-induced brief episodes of secondary mania in a depressed patient.

Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec


depressed [SEP] Triazolam-induced brief episodes of secondary mania in a depressed patient.

Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur


triazolam [SEP] Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elder


mania [SEP] Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disord


depressed [SEP] es of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) w


organic mental disorder [SEP] ief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident wi

Delirium, Dementia, Amnestic, Cognitive Disorders [SEP] Cognitive disorders including delirium, dementia, and other cognitive disorders. These may be the result of substance use, traum


delirium [SEP] a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the dur

Delirium [SEP] A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instan


Manic [SEP] eatures of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazo


triazolo [SEP] ration of action of triazolam. The possible contribution of the triazolo group to changes in affective status is discussed.


muscular rigidity [SEP] On the mechanisms of the development of tolerance to the muscular rigidity produced by morphine in rats.

Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m


morphine [SEP] e development of tolerance to the muscular rigidity produced by morphine in rats.

Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central


muscular rigidity [SEP] The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated con


morphine [SEP] e development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test do


rigidity [SEP] The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated con


akinetic [SEP] e that was not significantly less than in the controls and were akinetic (A group). The other rats showed a strong decrease in the rigid

Hypokinesia [SEP] Slow or diminished movement of body musculature. It may be associated with BASAL GANGLIA DISEASES; MENTAL DISORDERS; prolonged i


hyperkinetic [SEP] ereotyped (S) licking and/or gnawing in presence of akinetic or hyperkinetic (K) behaviour (AS/KS group), suggesting signs of dopaminergic a

Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.


haloperidol [SEP] s after 20 days' treatment. In a further series of experiments, haloperidol (0.2 mg/kg i.p.) was used in order to block the dopaminergic ac

Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa


Haloperidol [SEP] olerance to the rigidity without any dopaminergic interference. Haloperidol enhanced the rigidity in the A group. However, the level in the


Compression neuropathy [SEP] Compression neuropathy of the radial nerve due to pentazocine-induced fibrous myopathy

Nerve Compression Syndromes [SEP] Mechanical compression of nerves or nerve roots from internal or external causes. These may result in a conduction block to nerv


neuropathy of the radial nerve [SEP] Compression neuropathy of the radial nerve due to pentazocine-induced fibrous myopathy.

Radial Neuropathy [SEP] Disease involving the RADIAL NERVE. Clinical features include weakness of elbow extension, elbow flexion, supination of the fore


pentazocine [SEP] Compression neuropathy of the radial nerve due to pentazocine-induced fibrous myopathy.

Pentazocine [SEP] The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a


pentazocine [SEP] ibrous myopathy is a common, well-known side effect of repeated pentazocine injection. However, compression neuropathy due to fibrotic musc


compression neuropathy [SEP] l-known side effect of repeated pentazocine injection. However, compression neuropathy due to fibrotic muscle affected by pentazocine-induced myopathy


myopathy [SEP] Fibrous myopathy is a common, well-known side effect of repeated pentazocine inj

Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.


acute renal failure [SEP] Recurrent reversible acute renal failure from amphotericin.

Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney


amphotericin [SEP] Recurrent reversible acute renal failure from amphotericin.

Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.


cirrhosis [SEP] A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure i

Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other


sporotrichosis [SEP] A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the adminis

Sporotrichosis [SEP] The commonest and least serious of the deep mycoses, characterized by nodular lesions of the cutaneous and subcutaneous tissues.


acute renal failure [SEP] cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on f


amphotericin B [SEP] acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure


renal failure [SEP] genic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on f

Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain


renal dysfunction [SEP] thin days suggests that there was a functional component to the renal dysfunction. We propose that amphotericin, in the setting of reduced effect

Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.


amphotericin [SEP] acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failu


pericardial effusion [SEP] Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.

Pericardial Effusion [SEP] Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associa


neuropathy [SEP] Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.

Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph


amiodarone [SEP] tis with pleural and pericardial effusion and neuropathy during amiodarone therapy.

Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin


sinuatrial disease [SEP] A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum do

Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.


amiodarone [SEP] ith sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 mo


supraventricular tachyarrhythmias [SEP] g, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, a

Tachycardia, Supraventricular [SEP] A generic expression for any tachycardia that originates above the BUNDLE OF HIS.


pneumonitis [SEP]  for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proxima

Pneumonia [SEP] Inflammation of any part, segment or lobe, of the lung parenchyma.


pericardial effusions [SEP] ricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immediate but g


proximal motor neuropathy [SEP] monitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immediate but gradual improvement followed withdrawal of amiod

Neuromuscular Diseases [SEP] A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manif


prednisolone [SEP] mprovement followed withdrawal of amiodarone and treatment with prednisolone. Review of this and previously reported cases indicates the nee

Prednisolone [SEP] A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routin


steroid [SEP] s, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery.

Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso


Indomethacin [SEP] Indomethacin-induced renal insufficiency: recurrence on rechallenge.

Indomethacin [SEP] A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostagla


renal insufficiency [SEP] Indomethacin-induced renal insufficiency: recurrence on rechallenge.


renal failure [SEP] We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor


hyperkalemia [SEP] We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after i

Hyperkalemia [SEP] Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinicall


cirrhosis [SEP] cute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt


ascites [SEP] ic renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restorati

Ascites [SEP] Accumulation or retention of free fluid within the peritoneal cavity.


cor pulmonale [SEP] ure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal functio

Pulmonary Heart Disease [SEP] Hypertrophy and dilation of the RIGHT VENTRICLE of the heart that is caused by PULMONARY HYPERTENSION. This condition is often a


indomethacin [SEP] a in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug wit


oliguria [SEP] ngle dose of indomethacin caused recurrence of acute reversible oliguria. Our case supports the hypothesis that endogenous renal prostag

Oliguria [SEP] Decreased URINE output that is below the normal range. Oliguria can be defined as urine output of less than or equal to 0.5 or 1


prostaglandins [SEP] liguria. Our case supports the hypothesis that endogenous renal prostaglandins play a role in the maintenance of renal blood flow when circula

Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.


acute renal failure [SEP] agents interfere with this compensatory mechanism and may cause acute renal failure, they should be used with caution in such patients.

Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney


flunitrazepam [SEP] plasma concentrations following oral and i.m. administration of flunitrazepam in volunteers.

Flunitrazepam [SEP] A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indica


Flunitrazepam [SEP] Flunitrazepam 0.5, 1.0 or 2.0 mg was given by the oral or i.m. routes to grou


Dizziness [SEP] metimes lasted longer than those following oral administration. Dizziness was less marked than sedation, but increased with the dose. The

Dizziness [SEP] An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.


pain [SEP] ss marked than sedation, but increased with the dose. There was pain on i.m. injection of flunitrazepam significantly more often tha

Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.


flunitrazepam [SEP] ut increased with the dose. There was pain on i.m. injection of flunitrazepam significantly more often than with isotonic saline. Plasma conc


timolol [SEP] Changes in heart size during long-term timolol treatment after myocardial infarction.

Timolol [SEP] A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as


myocardial infarction [SEP] Changes in heart size during long-term timolol treatment after myocardial infarction.

Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).


timolol [SEP] The effect of long-term timolol treatment on heart size after myocardial infarction was evaluat


myocardial infarction [SEP] The effect of long-term timolol treatment on heart size after myocardial infarction was evaluated by X-ray in a double-blind study including 241 pa


bradycardia [SEP] acebo group. These differences may be caused by timolol-induced bradycardia and a compensatory increase in end-diastolic volume. The timolo

Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th


cardiomegaly [SEP] atients with normal and borderline heart size. In patients with cardiomegaly, the increase in heart size was similar in both groups. After r

Cardiomegaly [SEP] Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the l


infarction [SEP] t of long-term timolol treatment on heart size after myocardial infarction was evaluated by X-ray in a double-blind study including 241 pa

Infarction [SEP] Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most


Vitamin D3 [SEP] Vitamin D3 toxicity in dairy cows.

Cholecalciferol [SEP] Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in h


toxicity [SEP] Vitamin D3 toxicity in dairy cows.

Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem


vitamin D3 [SEP] Large parenteral doses of vitamin D3 (15 to 17.5 x 10(6) IU vitamin D3) were associated with prolong


hypercalcemia [SEP] 5 to 17.5 x 10(6) IU vitamin D3) were associated with prolonged hypercalcemia, hyperphosphatemia, and large increases of vitamin D3 and its m

Hypercalcemia [SEP] Abnormally high level of calcium in the blood.


hyperphosphatemia [SEP] 6) IU vitamin D3) were associated with prolonged hypercalcemia, hyperphosphatemia, and large increases of vitamin D3 and its metabolites in the b

Hyperphosphatemia [SEP] A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol


Calcium [SEP] od plasma of nonlactating nonpregnant and pregnant Jersey cows. Calcium concentrations 1 day postpartum were higher in cows treated wit

Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym


milk fever [SEP] 0 ml). None of the cows treated with vitamin D3 showed signs of milk fever during the peripartal period; however, 22% of the control cows

Parturient Paresis [SEP] A disease of pregnant and lactating cows and ewes leading to generalized paresis and death. The disease, which is characterized


toxicity [SEP] cal signs of milk fever during this period. Signs of vitamin D3 toxicity were not observed in nonlactating nonpregnant cows; however, pr


Diseases of peripheral nerves [SEP] Diseases of peripheral nerves as seen in the Nigerian African.

Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl


peripheral nerve disease [SEP] The anatomical and aetiological diagnoses of peripheral nerve disease excluding its primary benign and malignant disorders, as seen i


Sensori-motor neuropathy [SEP] e preponderance and the peak incidence is in the fourth decade. Sensori-motor neuropathy was the commonest presentation (50%). Guillain-Barr   syndrome


Guillain-Barr   syndrome [SEP]  Sensori-motor neuropathy was the commonest presentation (50%). Guillain-Barr   syndrome was the commonest identifiable cause (15.6%), accounting for ha

Guillain-Barre Syndrome [SEP] An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin


motor neuropathy [SEP] derance and the peak incidence is in the fourth decade. Sensori-motor neuropathy was the commonest presentation (50%). Guillain-Barr   syndrome


Peripheral neuropathy [SEP] 15.6%), accounting for half of the cases with motor neuropathy. Peripheral neuropathy due to nutritional deficiency of thiamine and riboflavin was co


nutritional deficiency [SEP] f the cases with motor neuropathy. Peripheral neuropathy due to nutritional deficiency of thiamine and riboflavin was common (10.1%) and presented mai

Malnutrition [SEP] An imbalanced nutritional status resulted from insufficient intake of nutrients to meet normal physiological requirement.


thiamine [SEP] ropathy. Peripheral neuropathy due to nutritional deficiency of thiamine and riboflavin was common (10.1%) and presented mainly as senso

Thiamine [SEP] 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.


riboflavin [SEP] pheral neuropathy due to nutritional deficiency of thiamine and riboflavin was common (10.1%) and presented mainly as sensory and sensori-

Riboflavin [SEP] Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is


sensori-motor neuropathy [SEP] boflavin was common (10.1%) and presented mainly as sensory and sensori-motor neuropathy. Diabetes mellitus was the major cause of autonomic neuropathy.


Diabetes mellitus [SEP] ) and presented mainly as sensory and sensori-motor neuropathy. Diabetes mellitus was the major cause of autonomic neuropathy. Isoniazid was the

Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.


autonomic neuropathy [SEP] sori-motor neuropathy. Diabetes mellitus was the major cause of autonomic neuropathy. Isoniazid was the most frequent agent in drug-induced neuropat

Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph


Isoniazid [SEP]  Diabetes mellitus was the major cause of autonomic neuropathy. Isoniazid was the most frequent agent in drug-induced neuropathy. Migrain

Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.


neuropathy [SEP] e and the peak incidence is in the fourth decade. Sensori-motor neuropathy was the commonest presentation (50%). Guillain-Barr   syndrome


Migraine [SEP] oniazid was the most frequent agent in drug-induced neuropathy. Migraine (20%) was not an uncommon cause of cranial neuropathy although

Migraine Disorders [SEP] A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtyp


cranial neuropathy [SEP] induced neuropathy. Migraine (20%) was not an uncommon cause of cranial neuropathy although malignancies arising from the reticuloendothelial syst

Cranial Nerve Diseases [SEP] Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disor


malignancies [SEP]  (20%) was not an uncommon cause of cranial neuropathy although malignancies arising from the reticuloendothelial system or related structur

Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me


connective tissue disorders [SEP] etiology of the neuropathy was undetermined. Heredofamilial and connective tissue disorders were rare. Some of the factors related to the clinical presenta

Connective Tissue Diseases [SEP] A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or


neuropathies [SEP] rs related to the clinical presentation and pathogenesis of the neuropathies are briefly discussed.


dothiepin hydrochloride [SEP] A double-blind study of the efficacy and safety of dothiepin hydrochloride in the treatment of major depressive disorder.

Dothiepin [SEP] A tricyclic antidepressant with some tranquilizing action.


depressive disorder [SEP] and safety of dothiepin hydrochloride in the treatment of major depressive disorder.

Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur


dothiepin [SEP] In a 6-week double-blind parallel treatment study, dothiepin and amitriptyline were compared to placebo in the treatment of


amitriptyline [SEP] n a 6-week double-blind parallel treatment study, dothiepin and amitriptyline were compared to placebo in the treatment of 33 depressed outpa

Amitriptyline [SEP] Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and


depressed [SEP] d amitriptyline were compared to placebo in the treatment of 33 depressed outpatients. Dothiepin and amitriptyline were equally effective


Dothiepin [SEP] mpared to placebo in the treatment of 33 depressed outpatients. Dothiepin and amitriptyline were equally effective in alleviating the sym


depressive illness [SEP] riptyline were equally effective in alleviating the symptoms of depressive illness, and both were significantly superior to placebo. The overall i


blurred vision [SEP] all incidence of side effects and the frequency and severity of blurred vision, dry mouth, and drowsiness were significantly less with dothiep

Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri


dry mouth [SEP]  side effects and the frequency and severity of blurred vision, dry mouth, and drowsiness were significantly less with dothiepin than wit

Xerostomia [SEP] Decreased salivary flow.


antidepressant [SEP] oratory parameters. Dothiepin thus was found to be an effective antidepressant drug associated with fewer side effects than amitriptyline in t

Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE


diazepam [SEP] Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia

Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio


propranolol [SEP] Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia.

Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A


panic disorder [SEP] Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia.

Panic Disorder [SEP] A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin wi


agoraphobia [SEP] of diazepam and propranolol in patients with panic disorder and agoraphobia.

Agoraphobia [SEP] Obsessive, persistent, intense fear of open places.


diazepam [SEP] The effects of oral doses of diazepam (single dose of 10 mg and a median dose of 30 mg/day for 2 week


propranolol [SEP] e dose of 10 mg and a median dose of 30 mg/day for 2 weeks) and propranolol (single dose of 80 mg and a median dose of 240 mg/day for 2 wee


panic disorders [SEP] /day for 2 weeks) on psychological performance of patients with panic disorders and agoraphobia were investigated in a double-blind, randomized


agoraphobia [SEP]  psychological performance of patients with panic disorders and agoraphobia were investigated in a double-blind, randomized and crossover d


impaired immediate free recall [SEP]  in a double-blind, randomized and crossover design. Both drugs impaired immediate free recall but the decrease was greater for diazepam than propranolol. Del

Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory


Delayed free recall was also impaired [SEP] all but the decrease was greater for diazepam than propranolol. Delayed free recall was also impaired but the two drugs did not differ. Patients tapped faster after


behavioral impairment [SEP]  subjects. Accumulation of drugs was not reflected in prolonged behavioral impairment.

Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho


aspirin [SEP] Effect of aspirin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced epithe

Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a


N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide [SEP] Effect of aspirin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced epithelial proliferation in the urinary bladder and for

FANFT [SEP] A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteri


aspirin [SEP] The co-administration of aspirin with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT) to r


N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide [SEP] The co-administration of aspirin with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT) to rats resulted in a reduced incidence of FANFT-induce


FANFT [SEP]  of aspirin with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT) to rats resulted in a reduced incidence of FANFT-induced bladd


bladder carcinomas [SEP] FANFT) to rats resulted in a reduced incidence of FANFT-induced bladder carcinomas but a concomitant induction of forestomach tumors. An autoradio

Urinary Bladder Neoplasms [SEP] Tumors or cancer of the URINARY BLADDER.


forestomach tumors [SEP] FANFT-induced bladder carcinomas but a concomitant induction of forestomach tumors. An autoradiographic study was performed on male F-344 rats fed

Stomach Neoplasms [SEP] Tumors or cancer of the STOMACH.


carcinogenesis [SEP] ment suggesting that different mechanisms are involved in FANFT carcinogenesis in the bladder and forestomach, and that aspirin's effect on FA

Carcinogenesis [SEP] The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between


hypotension [SEP] Provocation of postural hypotension by nitroglycerin in diabetic autonomic neuropathy?

Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI


nitroglycerin [SEP] Provocation of postural hypotension by nitroglycerin in diabetic autonomic neuropathy?

Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als


diabetic autonomic neuropathy [SEP] Provocation of postural hypotension by nitroglycerin in diabetic autonomic neuropathy?

Diabetic Neuropathies [SEP] Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result f


nitroglycerin [SEP] The effect of nitroglycerin on heart rate and systolic blood pressure was compared in 5 nor


diabetic [SEP] d systolic blood pressure was compared in 5 normal subjects, 12 diabetic subjects without autonomic neuropathy, and 5 diabetic subjects

Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.


autonomic neuropathy [SEP] was compared in 5 normal subjects, 12 diabetic subjects without autonomic neuropathy, and 5 diabetic subjects with autonomic neuropathy. The magnitu

Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph


estrogen [SEP] Characterization of estrogen-induced adenohypophyseal tumors in the Fischer 344 rat.

Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr


adenohypophyseal tumors [SEP] Characterization of estrogen-induced adenohypophyseal tumors in the Fischer 344 rat.

Pituitary Neoplasms [SEP] Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are di


Pituitary tumors [SEP] Pituitary tumors were induced in F344 female rats by chronic treatment with diet


diethylstilbestrol [SEP] mors were induced in F344 female rats by chronic treatment with diethylstilbestrol (DES, 8-10 mg) implanted subcutaneously in silastic capsules. O

Diethylstilbestrol [SEP] A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as


DES [SEP]  F344 female rats by chronic treatment with diethylstilbestrol (DES, 8-10 mg) implanted subcutaneously in silastic capsules. Over a


acriflavine [SEP] d by unit gravity sedimentation, and cell cycle analysis, after acriflavine DNA staining, by laser flow cytometry. Total cell yields from D

Acriflavine [SEP] 3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-acridinediamine. Fluorescent dye used as a local antiseptic and also as


tumor [SEP] Pituitary tumors were induced in F344 female rats by chronic treatment with die

Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me


Triamterene [SEP] Triamterene nephrolithiasis complicating dyazide therapy.

Triamterene [SEP] A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.


nephrolithiasis [SEP] Triamterene nephrolithiasis complicating dyazide therapy.

Nephrolithiasis [SEP] Formation of stones in the KIDNEY.


dyazide [SEP] Triamterene nephrolithiasis complicating dyazide therapy.

hydrochlorothiazide-triamterene [SEP]


triamterene [SEP] A case of triamterene nephrolithiasis is reported in a man after 4 years of hydrochlo


nephrolithiasis [SEP] A case of triamterene nephrolithiasis is reported in a man after 4 years of hydrochlorothiazide-triam


hydrochlorothiazide-triamterene [SEP] iamterene nephrolithiasis is reported in a man after 4 years of hydrochlorothiazide-triamterene therapy for hypertension. The stone passed spontaneously and wa

hydrochlorothiazide-triamterene [SEP]


hypertension [SEP] an after 4 years of hydrochlorothiazide-triamterene therapy for hypertension. The stone passed spontaneously and was found to contain a tria

Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c


adriamycin [SEP] Metabolic involvement in adriamycin cardiotoxicity.

Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.


cardiotoxicity [SEP] Metabolic involvement in adriamycin cardiotoxicity.

Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;


cardiotoxic [SEP] The cardiotoxic effects of adriamycin were studied in mammalian myocardial cell


adriamycin [SEP] The cardiotoxic effects of adriamycin were studied in mammalian myocardial cells in culture as a mode


Adriamycin [SEP] ied in mammalian myocardial cells in culture as a model system. Adriamycin inhibited cell growth and the rhythmic contractions characteris


phosphorylcreatine [SEP] d previously, and in this study the adenylate energy charge and phosphorylcreatine mole fraction were determined in the adriamycin-treated cells.

Phosphocreatine [SEP] An endogenous substance found mainly in skeletal muscle of vertebrates. It has been tried in the treatment of cardiac disorders


phophorylcreatine [SEP] nergy charge was found to be significantly decreased, while the phophorylcreatine mole fraction was unchanged. Such disparity suggests an inhibit


creatine [SEP] ly, and in this study the adenylate energy charge and phosphorylcreatine mole fraction were determined in the adriamycin-treated cells.

Creatine [SEP] An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Cr


adenosine [SEP] s an inhibition of creatine phosphokinase. The addition of 1 mM adenosine to the myocardial cell cultures markedly increases the ATP conc

Adenosine [SEP] A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles i


ATP [SEP] denosine to the myocardial cell cultures markedly increases the ATP concentration through a pathway reportedly leading to a compart

Adenosine Triphosphate [SEP] An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in meta


neurotoxic [SEP] Age-dependent sensitivity of the rat to neurotoxic effects of streptomycin.

Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method


streptomycin [SEP] Age-dependent sensitivity of the rat to neurotoxic effects of streptomycin.

Streptomycin [SEP] An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation proces


Streptomycin [SEP] Streptomycin sulfate (300 mg/kg s.c.) was injected for various periods into


Abnormal movements [SEP] d hearing were examined for 6 and up to 17 weeks, respectively. Abnormal movements and deafness occurred only in rats treated during the preweanin

Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or


deafness [SEP]  for 6 and up to 17 weeks, respectively. Abnormal movements and deafness occurred only in rats treated during the preweaning period; wit

Deafness [SEP] A general term for the complete loss of the ability to hear from both ears.


streptomycin [SEP]  respectively, indicating that the cochlea is more sensitive to streptomycin than the site (vestibular or central) responsible for the dyski


dyskinesias [SEP] mycin than the site (vestibular or central) responsible for the dyskinesias.


glomerulonephritis [SEP] Crescentic fibrillary glomerulonephritis associated with intermittent rifampin therapy for pulmonary tub

Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti


rifampin [SEP] ntic fibrillary glomerulonephritis associated with intermittent rifampin therapy for pulmonary tuberculosis.

Rifampin [SEP] A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity ag


pulmonary tuberculosis [SEP] rulonephritis associated with intermittent rifampin therapy for pulmonary tuberculosis.

Tuberculosis, Pulmonary [SEP] MYCOBACTERIUM infections of the lung.


glomerulonephritis [SEP]  reveals an unusual finding of rapidly proliferative crescentic glomerulonephritis in a patient treated with rifampin who had no other identifiabl


rifampin [SEP] erative crescentic glomerulonephritis in a patient treated with rifampin who had no other identifiable causes for developing this diseas


isoniazid [SEP] ease. This patient underwent a 10-month regimen of rifampin and isoniazid for pulmonary tuberculosis and was discovered to have developed

Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.


pulmonary tuberculosis [SEP] ient underwent a 10-month regimen of rifampin and isoniazid for pulmonary tuberculosis and was discovered to have developed signs of severe renal fail


renal failure [SEP] berculosis and was discovered to have developed signs of severe renal failure five weeks after completion of therapy. Renal biopsy revealed s

Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain


puromycin aminonucleoside [SEP] Time course of lipid peroxidation in puromycin aminonucleoside-induced nephropathy.

Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl


nephropathy [SEP] urse of lipid peroxidation in puromycin aminonucleoside-induced nephropathy.

Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.


oxygen [SEP] Reactive oxygen species have been implicated in the pathogenesis of acute purom

Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear


puromycin aminonucleoside [SEP] xygen species have been implicated in the pathogenesis of acute puromycin aminonucleoside (PAN)-induced nephropathy, with antioxidants significantly redu


PAN [SEP] licated in the pathogenesis of acute puromycin aminonucleoside (PAN)-induced nephropathy, with antioxidants significantly reducing


nephropathy [SEP] e pathogenesis of acute puromycin aminonucleoside (PAN)-induced nephropathy, with antioxidants significantly reducing the proteinuria. The


proteinuria [SEP] duced nephropathy, with antioxidants significantly reducing the proteinuria. The temporal relationship between lipid peroxidation in the ki

Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.


thiobarbituric acid [SEP] le homogenates as well as in lipid extracts from homogenates as thiobarbituric acid reactive substances. Proteinuria was evident at day 5, peaked a

thiobarbituric acid [SEP]


Proteinuria [SEP] ts from homogenates as thiobarbituric acid reactive substances. Proteinuria was evident at day 5, peaked at day 7 and persisted to day 27.


proteinuric injury [SEP]  study supports the role of lipid peroxidation in mediating the proteinuric injury in PAN nephropathy.


Clomipramine [SEP] Clomipramine-induced sleep disturbance does not impair its prolactin-releasi

Clomipramine [SEP] A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily a


sleep disturbance [SEP] Clomipramine-induced sleep disturbance does not impair its prolactin-releasing action.

Sleep Disorders [SEP] Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major c


sleep disturbance [SEP] The present study was undertaken to examine the role of sleep disturbance, induced by clomipramine administration, on the secretory rate


clomipramine [SEP] undertaken to examine the role of sleep disturbance, induced by clomipramine administration, on the secretory rate of prolactin (PRL) in add


Angioedema [SEP] Angioedema following the intravenous administration of metoprolol.

Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i


metoprolol [SEP] Angioedema following the intravenous administration of metoprolol.

Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI


pulmonary edema [SEP] A 72-year-old woman was admitted to the hospital with "flash" pulmonary edema, preceded by chest pain, requiring intubation. Her medical hist

Pulmonary Edema [SEP] Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary


chest pain [SEP] itted to the hospital with "flash" pulmonary edema, preceded by chest pain, requiring intubation. Her medical history included coronary ar

Chest Pain [SEP] Pressure, burning, or numbness in the chest.


coronary artery disease [SEP]  chest pain, requiring intubation. Her medical history included coronary artery disease with previous myocardial infarctions, hypertension, and diabete

Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot


myocardial infarctions [SEP]  medical history included coronary artery disease with previous myocardial infarctions, hypertension, and diabetes mellitus. A history of angioedema s

Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).


hypertension [SEP] d coronary artery disease with previous myocardial infarctions, hypertension, and diabetes mellitus. A history of angioedema secondary to li

Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c


diabetes mellitus [SEP] disease with previous myocardial infarctions, hypertension, and diabetes mellitus. A history of angioedema secondary to lisinopril therapy was el

Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.


angioedema [SEP]  infarctions, hypertension, and diabetes mellitus. A history of angioedema secondary to lisinopril therapy was elicited. Current medicatio


lisinopril [SEP] on, and diabetes mellitus. A history of angioedema secondary to lisinopril therapy was elicited. Current medications did not include angio

Lisinopril [SEP] One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hype


angiotensin [SEP] opril therapy was elicited. Current medications did not include angiotensin-converting enzyme inhibitors or beta-blockers. She had no previ

Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG


metoprolol [SEP] the first day of hospitalization (while intubated), intravenous metoprolol was given, resulting in severe angioedema. The angioedema resol


steroids [SEP] ioedema. The angioedema resolved after therapy with intravenous steroids and diphenhydramine hydrochloride.

Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso


diphenhydramine [SEP] angioedema resolved after therapy with intravenous steroids and diphenhydramine hydrochloride.

Diphenhydramine [SEP] A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a


coniine [SEP] Effect of coniine on the developing chick embryo.

coniine [SEP]