SoroushVahidi/scidocs huggingface dataset:
Combination therapy : Synergism between natural plant extracts and antibiotics against infectious diseases
(2012)

Antibiotics are one of the most important weapons in fighting bacterial infections and have greatly benefited the health‐related quality of human life since their introduction. However, over the past few decades these health benefits are under threat as many commonly used antibiotics have become less and less effective against certain illnesses not only because many of them produce toxic reactions but also due to emergence of drug resistant bacteria. Resistance development is an even bigger problem since the bacterial resistance is often not restricted to the specific antibiotic prescribed, but generally extends to other compounds of the same class. Bacterial resistance and its rapid increase is a major concern of global public health and is emerging as one of the most significant challenges to human health. Treating bacterial infections by antibiotics is beneficial but their indiscriminate use has led to an alarming resistance among microorganisms as well as led to re-emergence of old infectious diseases. One approach to treat infectious diseases is the use of plant extracts individually and /or as an alternative approach is the use of combination of antibiotics with plant extracts. This latter approach i.e. combination therapy or synergistic therapy; against resistant microorganisms may lead to new ways of treating infectious diseases and probably this represents a potential area for further future investigations. Combination therapy is helpful and useful for patients with serious infections caused by drug resistant pathogens. The present review describes in detail, the observed synergy between natural extracts and standard antibiotics combating bacterial and fungal infections. The mode of action of combination therapy significantly differs from that of the same drugs acting individually; therefore the selection of an appropriate combination is crucial and essential which requires understanding the potential interaction between the plant extracts and antimicrobial agents.
Social ties and mental health
(2001)

It is generally agreed that social ties play a beneficial role in the maintenance of psychological well-being. In this targeted review, we highlight four sets of insights that emerge from the literature on social ties and mental health outcomes (defined as stress reactions, psychological well-being, and psychological distress, including depressive symptoms and anxiety). First, the pathways by which social networks and social supports influence mental health can be described by two alternative (although not mutually exclusive) causal models—the main effect model and the stress-buffering model. Second, the protective effects of social ties on mental health are not uniform across groups in society. Gender differences in support derived from social network participation may partly account for the higher prevalence of psychological distress among women compared to men. Social connections may paradoxically increase levels of mental illness symptoms among women with low resources, especially if such connections entail role strain associated with obligations to provide social support to others. Third, egocentric networks are nested within a broader structure of social relationships. The notion of social capital embraces the embeddedness of individual social ties within the broader social structure. Fourth, despite some successes reported in social support interventions to enhance mental health, further work is needed to deepen our understanding of the design, timing, and dose of interventions that work, as well as the characteristics of individuals who benefit the most.
The inhibitors of apoptosis (IAPs) as cancer targets
(2007)

Apoptosis has been accepted as a fundamental component in the pathogenesis of cancer, in addition to other human diseases including neurodegeneration, coronary disease and diabetes. The origin of cancer involves deregulated cellular proliferation and the suppression of apoptotic processes, ultimately leading to tumor establishment and growth. Several lines of evidence point toward the IAP family of proteins playing a role in oncogenesis, via their effective suppression of apoptosis. The central mechanisms of IAP apoptotic suppression appear to be through direct caspase and pro-caspase inhibition (primarily caspase 3 and 7) and modulation of, and by, the transcription factor NF-kappaB. Thus, when the IAPs are over-expressed or over-active, as is the case in many cancers, cells are no longer able to die in a physiologically programmed fashion and become increasingly resistant to standard chemo- and radiation therapies. To date several approaches have been taken to target and eliminate IAP function in an attempt to re-establish sensitivity, reduce toxicity, and improve efficacy of cancer treatment. In this review, we address IAP proteins as therapeutic targets for the treatment of cancer and emphasize the importance of novel therapeutic approaches for cancer therapy. Novel targets of IAP function are being identified and include gene therapy strategies and small molecule inhibitors that are based on endogenous IAP antagonists. As well, molecular mechanistic approaches, such as RNAi to deplete IAP expression, are in development.
Large-Scale Analysis of Soccer Matches Using Spatiotemporal Tracking Data
(2014)

Although the collection of player and ball tracking data is fast becoming the norm in professional sports, large-scale mining of such spatiotemporal data has yet to surface. In this paper, given an entire season's worth of player and ball tracking data from a professional soccer league (≈400,000,000 data points), we present a method which can conduct both individual player and team analysis. Due to the dynamic, continuous and multi-player nature of team sports like soccer, a major issue is aligning player positions over time. We present a "role-based" representation that dynamically updates each player's relative role at each frame and demonstrate how this captures the short-term context to enable both individual player and team analysis. We discover role directly from data by utilizing a minimum entropy data partitioning method and show how this can be used to accurately detect and visualize formations, as well as analyze individual player behavior.
Motor skill acquisition.
(1991)

INTRODUCTION ..................................................................................... 213 A GENERAL LAW OF MOTOR LEARNING ................................................. 215 Motor Learning as a Power Law .............................................................. 216 The Power Law--A Special Case of Motor Learning? .................................... 217 WHAT IS LEARNED WITH PRACTICE ....................................................... 219 One-To-One R call-Recognition Processes .................................................. 219 Schema Representation of Action .............................................................. 221 Problems with Prescriptive Accounts of Motor Learning ................................. 223 Motor Skill Acquisition as a Search Strategy ............................................... 224 INFORMATION A D MOTOR SKILL ACQUISITION ..................................... 225 Information as a Prescription .................................................................. 226 Information as Feedback ........................................................................ 227 Information to Channel the Search ............................................................ 231 CONCLUDING REMARKS ........................................................................ 233
Bayesian Estimation of a Stochastic Volatility Model Using Option and Spot Prices : Application of a Bivariate Kalman Filter
(2002)

In this paper Bayesian methods are applied to a stochastic volatility model using both the prices of the asset and the prices of options written on the asset. Posterior densities for all model parameters, latent volatilities and the market price of volatility risk are produced via a hybrid Markov Chain Monte Carlo sampling algorithm. Candidate draws for the unobserved volatilities are obtained using the Kalman filter and smoother to a linearization of a statespace representation of the model. The method is illustrated using the Heston (1993) stochastic volatility model applied to Australian News Corporation spot and option price data. Alternative models nested in the Heston framework are ranked via Bayes Factors and via fit, predictive and hedging performance.
Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like Behaviors through Reduced Secretion of FGF2
(2015)

NG2-expressing glia (NG2 glia) are a uniformly distributed and mitotically active pool of cells in the central nervous system (CNS). In addition to serving as progenitors of myelinating oligodendrocytes, NG2 glia might also fulfill physiological roles in CNS homeostasis, although the mechanistic nature of such roles remains unclear. Here, we report that ablation of NG2 glia in the prefrontal cortex (PFC) of the adult brain causes deficits in excitatory glutamatergic neurotransmission and astrocytic extracellular glutamate uptake and induces depressive-like behaviors in mice. We show in parallel that chronic social stress causes NG2 glia density to decrease in areas critical to Major Depressive Disorder (MDD) pathophysiology at the time of symptom emergence in stress-susceptible mice. Finally, we demonstrate that loss of NG2 glial secretion of fibroblast growth factor 2 (FGF2) suffices to induce the same behavioral deficits. Our findings outline a pathway and role for NG2 glia in CNS homeostasis and mood disorders.
Substrate Integrated Waveguide Quasi-Elliptic Filter Using Slot-Coupled and Microstrip-Line Cross-Coupled Structures
(2016)

This paper proposes a quasi-elliptic filter with slot coupling and nonadjacent cross coupling based on the substrate integrated waveguide (SIW) cavity. The slots etched on the top metal plane of SIW cavity are used to produce electrical coupling, and the cross coupling is realized by the microstrip transmission line above the SIW cavity. The coupling strength is mainly controlled by the width and height of the slot. The length of the open-ended microstrip line controls the sign of the cross coupling. The cross coupling with different signs are used in the filter to produce a pair of transmission zeros (TZs) at both sides of the passband. In order to prove the validity, a fourth-order SIW quasi-elliptic filter with TZsat both sides of the passband is fabricated in a two-layer printed circuit board. The measured insertion loss at a center frequency of 3.7 GHz is 1.1 dB. The return loss within the passband is below -18 dB with a fractional bandwidth of 16%. The measured results are in good agreement with the simulated results.
A distributed ADMM approach for mobile data offloading in software defined network
(2015)

Mobile data offloading has been introduced to alleviate the congestion of cellular networks and to improve the quality of service for mobile end users. This paper presents a distributed mechanism for mobile data offloading in software defined network (SDN) at the network edge. In SDN, the data traffic of base stations (BSs) can be dynamically offloaded to access points (APs), which is enabled by the SDN controller. The SDN controller formulates a revenue maximization problem to optimize the data offloading decision, and solves the problem in a fully distributed fashion. The proposed mechanism is based on the proximal Jacobian multi-block alternating direction method of multipliers (ADMM). BSs and APs perform the offloading decision update concurrently, and are coordinated by the SDN controller through dual variables to reach a consensus on the offloading demand and supply. Numerical simulations validate the effectiveness of the proposed algorithm.
A Sequential Importance Sampling Algorithm for Generating Random Graphs with Prescribed Degrees
(2011)

Random graphs with a given degree sequence are a useful model capturing several features absent in the classical Erdős-Rényi model, such as dependent edges and non-binomial degrees. In this paper, we use a characterization due to Erdős and Gallai to develop a sequential algorithm for generating a random labeled graph with a given degree sequence. The algorithm is easy to implement and allows surprisingly efficient sequential importance sampling. Applications are given, including simulating a biological network and estimating the number of graphs with a given degree sequence.
Immersive Analytics for Clinical Neuroscience
(2017)

This paper introduces NeuroCave, an open-source immersive analytics software tool for exploring and making sense of both structural and functional connectomes describing the interconnectivity between brain regions. The software supports visual analysis tasks for clinical neuroscientists, facilitating explorations of connectome datasets used in comparative group studies. Researchers can enter and leave virtual reality as desired in order to visualize and reason about connectome datasets from a range of different perspectives.
An Improved Topology of SEPIC Converter With Reduced Output Voltage Ripple
(2008)

An improved version of a single-ended primary inductor converter (SEPIC) is presented. The converter consists of a conventional SEPIC converter plus an additional high-frequency transformer and diode to maintain a freewheeling mode of the DC inductor currents during the switch on state. The voltage conversion ratio characteristics and semiconductor device voltage and current stresses are characterized. The main advantages of this converter are the continuous output current, smaller output voltage ripple, and lower semiconductors current stress compared with the conventional SEPIC converter. The design and simulation of the concept is verified by an experiment with a 48-V input and 12-V/3.75-A output converter.
A single-layer folded substrate integrated waveguide (SIW) filter
(2005)

A novel single-layer folded filter using the substrate integrated waveguide (SIW) technique is presented in this paper. A prototype at X-band for the proposed filter has been fabricated using standard printed-circuit-board (PCB) process, and is measured with a vector network analyzer (VNA). The measured results show the proposed filter has a narrow band-pass bandwidth, small insert loss and good frequency selective performances. The proposed filter has a compact size and it is suitable for designing microwave and millimeter-wave circuits.
Substrate Integrated Waveguide-to-Microstrip Transition in Multilayer Substrate
(2007)

This paper presents a novel transition between a microstrip line and a substrate integrated waveguide (SIW) in a multilayer substrate design environment. In order to achieve a low-loss broadband response, the transition, consisting of a tapered or multisectional ridged SIW and a tapered microstrip line, is modeled and designed by simultaneously considering both impedance matching and field matching. Characteristic impedance and guided wavelength calculated by using closed-form expressions based on a transverse resonant method are used to develop our design procedure. Effective broad bandwidth is obtained in two examples developed in this study, which are validated with simulated and measured results. This transition provides a simple way to design substrate integrated circuits with buried microstrip circuits in the multilayer substrate in which any ratio of impedance transform can be anticipated.
Integrated transition of coplanar to rectangular waveguides
(2001)

Usual transitions between planar circuit and rectangular waveguide make use of 3-D complex mounting structures. Such an integration requires costly high precision mechanical alignment, In this paper, a new planar platform is developed in which a coplanar waveguide (CPW) and a rectangular waveguide are fully integrated on the same substrate, and they are interconnected via a simple transition. They can be built with a standard PCB process. Our experiments at 28 GHz show that an effective bandwidth of 7% at 15 dB return loss can easily be achieved. The CPW-to-waveguide transition allows for a complete integration of waveguide components on substrate with active components such as MMIC.
The substrate integrated circuits - a new concept for high-frequency electronics and optoelectronics
(2003)

A new generation of high-frequency integrated circuits is presented, which is called substrate integrated circuits (SICs). Current state-of-the-art of circuit design and implementation platforms based on this new concept are reviewed and discussed in detail. Different possibilities and numerous advantages of the SICs are shown for microwave, millimeter-wave and optoelectronics applications. Practical examples are illustrated with theoretical and experimental results for substrate integrated waveguide (SIW), substrate integrated slab waveguide (SISW) and substrate integrated nonradiating dielectric (SINRD) guide circuits. Future research and development trends are also discussed with reference to low-cost innovative design of millimeter-wave and optoelectronic integrated circuits.
Biologically Plausible, Human-Scale Knowledge Representation
(2013)

Several approaches to implementing symbol-like representations in neurally plausible models have been proposed. These approaches include binding through synchrony (Shastri & Ajjanagadde, ), "mesh" binding (van der Velde & de Kamps, ), and conjunctive binding (Smolensky, ). Recent theoretical work has suggested that most of these methods will not scale well, that is, that they cannot encode structured representations using any of the tens of thousands of terms in the adult lexicon without making implausible resource assumptions. Here, we empirically demonstrate that the biologically plausible structured representations employed in the Semantic Pointer Architecture (SPA) approach to modeling cognition (Eliasmith, ) do scale appropriately. Specifically, we construct a spiking neural network of about 2.5 million neurons that employs semantic pointers to successfully encode and decode the main lexical relations in WordNet, which has over 100,000 terms. In addition, we show that the same representations can be employed to construct recursively structured sentences consisting of arbitrary WordNet concepts, while preserving the original lexical structure. We argue that these results suggest that semantic pointers are uniquely well-suited to providing a biologically plausible account of the structured representations that underwrite human cognition.
Poststroke fatigue: a 2-year follow-up study of stroke patients in Sweden.
(2002)

BACKGROUND AND PURPOSE
Fatigue is common among stroke patients. This study determined the prevalence of fatigue among long-term survivors after stroke and what impact fatigue had on various aspects of daily life and on survival.


METHODS
This study was based on Riks-Stroke, a hospital-based national register for quality assessment of acute stroke events in Sweden. During the first 6 months of 1997, 8194 patients were registered in Riks-Stroke, and 5189 were still alive 2 years after the stroke. They were followed up by a mail questionnaire, to which 4023 (79%) responded. Patients who reported that they always felt depressed were excluded.


RESULTS
To the question, "Do you feel tired?" 366 (10.0%) of the patients answered that they always felt tired, and an additional 1070 (29.2%) were often tired. Patients who always felt tired were on average older than the rest of the study population (74.5 versus 71.5 years, P<0.001); therefore, all subsequent analyses were age adjusted. Fatigue was an independent predictor for having to move into an institutional setting after stroke. Fatigue was also an independent predictor for being dependent in primary activities of daily living functions. Three years after stroke, patients with fatigue also had a higher case fatality rate.


CONCLUSIONS
Fatigue is frequent and often severe, even late after stroke. It is associated with profound deterioration of several aspects of everyday life and with higher case fatality, but it usually receives little attention by healthcare professionals. Intervention studies are needed.
Microcontroller Based Fan Speed Regulator with Continuous Monitoring using LCD Display
(2016)

Design and implementation of Microcontroller based automatic Fan speed regulator using temperature sensor is represented here. Most of the available Fans today are controlled manually by voltage regulators which have different stages of speed. During summer nights, especially the room temperature is initially quite high, as time passes, the temperature starts dropping. Also, after a person falls asleep, the metabolic rate of one’s body decreases, and one is expected to wake up from time to time to adjust the speed of the Fan. Many people who are disabled / physically challenged persons are affected the most because of the inconveniences associated in changing the Fan speed level manually when the room temperature changes. So, an efficient automatic Fan speed control system that automatically changes the speed level according to the change in environment / room temperature which is more comfortable than manual system. This project has been designed in such a way that the required components are available in local market. Therefore an indigenous low cost control scheme has been developed which can be used in real life application.
Development of an Autonomous Remote Access Water Quality Monitoring System
(2017)

Due to the vast increase in global industrial output, rural to urban drift and the over-utilization of land and sea resources, the quality of water available to people has deteriorated greatly. Before the sensor based approach to water quality monitoring, water quality was tested by collecting the samples of water and experimentally analyzing it in the laboratories. However, in today, with time being a scarce resource, the traditional method of water quality testing is not efficient anymore. To tackle this issue, several electronic (microcontroller and sensor based) water quality monitoring systems were developed in the past decade. However, an in depth study of this current water quality testing technology shows that there are some limitations that should be taken into consideration. Therefore, an automatic, remote, and low cost water quality monitoring system has been developed. This system consists of a core microcontroller, multiple sensors, GSM module, LCD display screen, and an alarm subsystem. The quality of water is read from the physical world through the water quality testing sensors and sent to the microcontroller. The data is then analyzed by the microcontroller and the result is displayed on the LCD screen on the device. At the same time, another copy of the sensor readings is sent remotely to the user’s mobile phone in the form of SMS. If an abnormal water quality parameter is detected by any sensor, the alarm system will turn on the respective red LED for that parameter and the buzzer will give warning sound. At the same time, the abnormality of the water parameter is reported to the user through SMS. The system is aimed to be used for wide applications and by all categories of users. It can facilitate the process of water quality monitoring autonomously and with low cost; to help people improve their quality of drinking water, household water supplies and aquaculture farms, especially in rural areas where residents do not have access to standardized water supply and suffer from different diseases caused by contaminated water.