Aperture scanning Fourier ptychographic microscopy
(2016)

Fourier ptychographic microscopy (FPM) is implemented through aperture scanning by an LCOS spatial light modulator at the back focal plane of the objective lens. This FPM configuration enables the capturing of the complex scattered field for a 3D sample both in the transmissive mode and the reflective mode. We further show that by combining with the compressive sensing theory, the reconstructed 2D complex scattered field can be used to recover the 3D sample scattering density. This implementation expands the scope of application for FPM and can be beneficial for areas such as tissue imaging and wafer inspection. c © 2016 Optical Society of America OCIS codes: (180.0180) Microscopy; (090.1995) Digital holography; (110.6880) Three-dimensional image acquisition. References and links 1. G. Zheng, R. Horstmeyer, and C. Yang, “Wide-field, high-resolution Fourier ptychographic microscopy,” Nat. Photonics 7, 739–745 (2013). 2. R. Horstmeyer and C. Yang, “A phase space model of Fourier ptychographic microscopy,” Opt. Express 22, 338–358 (2014). 3. X. Ou, R. Horstmeyer, G. Zheng, and C. Yang, “High numerical aperture Fourier ptychography: principle, implementation and characterization,” Opt. Express 23, 3472–3491 (2015). 4. X. Ou, R. Horstmeyer, C. Yang, and G. Zheng, “Quantitative phase imaging via Fourier ptychographic microscopy,” Opt. Lett. 38, 4845–4848 (2013). 5. L. Tian and L. Waller, “3D intensity and phase imaging from light field measurements in an LED array microscope,” Optica 2, 104–111 (2015). 6. R. Horstmeyer, J. Chung, X. Ou, G. Zheng, and C. Yang„ “Diffraction tomography with Fourier ptychography,” Optica 3, 827–835 (2016). 7. S. Dong, R. Horstmeyer, R. Shiradkar, K. Guo, X. Ou, Z. Bian, H. Xin, and G. Zheng, “Aperture-scanning Fourier ptychography for 3D refocusing and super-resolution macroscopic imaging,” Opt. Express 22, 13586–13599 (2014). 8. R. Horstmeyer, X. Ou, J. Chung, G. Zheng, and C. Yang, “Overlapped Fourier coding for optical aberration removal,” Opt. Express 22, 24062–24080 (2014). 9. S. Dong, Z. Bian, R. Shiradkar, and G. Zheng, “Sparsely sampled Fourier ptychography,” Opt. Express 22, 5455–5464 (2014). 10. S. Kubota and J. W. Goodman, “Very efficient speckle contrast reduction realized by moving diffuser device,” Appl. Opt. 49, 4385–4391 (2010). 11. R. Horstmeyer, R. Heintzmann, G. Popescu, L. Waller, and C. Yang, “Standardizing the resolution claims for coherent microscopy,” Nat. Photonics 10, 68–71 (2016). 12. J. W. Goodman, “Introduction to Fourier Optics,” (Roberts and Company Publishers, 2005), 1st ed. 13. E. J. Candès, J. Romberg, and T. Tao, “Robust uncertainty principles: Exact signal reconstruction from highly incomplete frequency information,” IEEE Trans. Inf. Theory 52, 489–509 (2006). 14. E. J. Candès, and T. Tao„ “Near-optimal signal recovery from random projections: Universal encoding strategies?,” IEEE Trans. Inf. Theory 52, 5406–5425 (2006). 15. D. L. Donoho, “Compressed sensing,” IEEE Trans. Inf. Theory 52, 1289–1306 (2006). 16. D. J. Brady, K. Choi, D. L. Marks, R. Horisaki, and S. Lim, “Compressive holography,” Opt. Express 17, 13040– 13049 (2009). 17. M.Born, “Quantenmechanik der stoßvorgänge,” Zeitschrift für Physik 38, 803–827 (1926). 18. R. E. Blahut, Theory of Remote Image Formation (Cambridge University Press, 2004). 19. E. J. Candès and T. Tao, “Decoding by linear programming,” IEEE Trans. Inf. Theory 51, 4203–4215 (2005). 20. L. I. Rudin, S. Osher, and E. Fatemi, “Nonlinear total variation based noise removal algorithms,” Physica D. 60, 259–268 (1992). 21. J. M. Bioucas-Dias and M. A. Figueiredo, “A new TwIST: two-step iterative shrinkage/thresholding algorithms for image restoration,” IEEE Trans. Image Process. 16, 2992–3004 (2007). Vol. 7, No. 8 | 1 Aug 2016 | BIOMEDICAL OPTICS EXPRESS 3140 #263394 Journal © 2016 http://dx.doi.org/10.1364/BOE.7.003140 Received 20 Apr 2016; revised 23 Jun 2016; accepted 17 Jul 2016; published 29 Jul 2016 22. J. M. Bioucas-Dias and M. A. Figueiredo, “Two-step Iterative Shrinkage/Thresholding Algorithm for Linear Inverse Problems,” http://www.lx.it.pt/ bioucas/TwIST/TwIST.htm 23. E. J. Candès, J .K. Romberg, and T. Tao, “Stable signal recovery from incomplete and inaccurate measurements,” Comm. Pure and Applied Math. 59, 1207–1223 (2006). 24. J. Mairal, J. Ponce, G. Sapiro, A. Zisserman, and F. R. Bach, “Supervised dictionary learning,” Proc. Adv. Neural Inf. Process. Syst. Conf. pp. 1033âĂŞ1040 (2009). 25. I. Yamaguchi and T. Zhang, “Phase-shifting digital holography,” Opt. Lett. 22, 1268–1270 (1997).