Anchor: While biological mechanisms for this effect have not yet been definitively established, the weight of the available epidemiological evidence supports an assumption of causality.
Entailed: Current epidemiological evidence shows some causality.
Contradiction: The biological mechanisms for this effect have already been proven.
Contradiction: Panhandle is somewhere in the south.
Contradiction: a railroad is being worked on
Contradiction: We should do something immediately.
Contradiction: Yes, that sounds just fine.