Kotaro Tsuboyama, Justas Dauparas, Jonathan Chen, Elodie Laine, Yasser Mohseni Behbahani, Jonathan J. Weinstein, Niall M. Mangan, Sergey Ovchinnikov, and Gabriel J. Rocklin. Mega-scale experimental analysis of protein folding stability in biology and design. Nature, 620(7973):434-444, August 2023. ISSN 0028-0836, 1476-4687. doi: 10.1038/s41586-023-06328-6. URL https://www.nature.com/articles/s41586-023-06328-6.
UK Monogenic Diabetes Consortium, Myocardial Infarction Genetics Consortium, UK Congenital Lipodystrophy Consortium, Amit R Majithia, Ben Tsuda, Maura Agostini, Keerthana Gnanapradeepan, Robert Rice, Gina Peloso, Kashyap A Patel, Xiaolan Zhang, Marjoleine F Broekema, Nick Patterson, Marc Duby, Ted Sharpe, Eric Kalkhoven, Evan D Rosen, Ines Barroso, Sian Ellard, Sekar Kathiresan, Stephen O'Rahilly, Krishna Chatterjee, Jose C Florez, Tarjei Mikkelsen, David B Savage, and David Altshuler. Prospective functional classification of all possible missense variants in PPARG. Nature Genetics, 48(12):1570-1575, December 2016. ISSN 1061-4036, 1546-1718. doi: 10.1038/ng.3700. URL https://www.nature.com/articles/ng.3700.
Fabio Urbina, Filippa Lentzos, Cédric Invernizzi, and Sean Ekins. Dual use of artificial-intelligence-powered drug discovery. Nature Machine Intelligence, 4(3):189-191, 2022.
Oana Ursu, James T Neal, Emily Shea, Pratiksha I Thakore, Livnat Jerby-Arnon, Lan Nguyen, Danielle Dionne, Celeste Diaz, Julia Bauman, Mariam Mounir Mosaad, Christian Fagre, April Lo, Maria McSharry, Andrew O Giacomelli, Seav Huong Ly, Orit Rozenblatt-Rosen, William C Hahn, Andrew J Aguirre, Alice H Berger, Aviv Regev, and Jesse S Boehm. Massively parallel phenotyping of coding variants in cancer with perturb-seq. Nature Biotechnology, 40(6):896-905, June 2022.
Warren van Loggerenberg, Shahin Sowlati-Hashjin, Jochen Weile, Rayna Hamilton, Aditya Chawla, Marinella Gebbia, Nishka Kishore, Laure Frésard, Sami Mustajoki, Elena Pischik, Elena Di Pierro, Michela Barbaro, Ylva Floderus, Caroline Schmitt, Laurent Gouya, Alexandre Colavin, Robert Nussbaum, Edith C H Friesema, Raili Kauppinen, Jordi To-Figueras, Aasne K Aarsand, Robert J Desnick, Michael Garton, and Frederick P Roth. Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation. bioRxiv, February 2023.
Rosario Vanella, Christoph Kung, Alexandre A Schoepfer, Vanni Doffini, Jin Ren, and Michael A Nash. Understanding Activity-Stability tradeoffs in biocatalysts by enzyme proximity sequencing. March 2023.
Ashish Vaswani, Noam Shazeer, Niki Parmar, Jakob Uszkoreit, Llion Jones, Aidan N. Gomez, Lukasz Kaiser, and Illia Polosukhin. Attention is all you need, 2017.
Veeramohan Veerapandian, Jan Ole Ackermann, Yogesh Srivastava, Vikas Malik, Mingxi Weng, Xiaoxiao Yang, and Ralf Jauch. Directed evolution of reprogramming factors by cell selection and sequencing. *Stem Cell Reports*, 11(2):593–606, August 2018.
Aliete Wan, Emily Place, Eric A. Pierce, and Jason Comander. Characterizing variants of unknown significance in rhodopsin: A functional genomics approach. Human Mutation, 40(8):1127-1144, August 2019. ISSN 1059-7794, 1098-1004. doi: 10.1002/humu.23762. URL https://onlinelibrary.wiley.com/doi/10.1002/humu.23762.
Ryan Weeks and Marc Ostermeier. Fitness and functional landscapes of the e. coli RNase III gene rnc. Molecular Biology and Evolution, 40(3), March 2023.
Jochen Weile, Song Sun, Atina G Cote, Jennifer Knapp, Marta Verby, Joseph C Mellor, Yingzhou Wu, Carles Pons, Cassandra Wong, Natascha Lieshout, Fan Yang, Murat Tasan, Guihong Tan, Shan Yang, Douglas M Fowler, Robert Nussbaum, Jesse D Bloom, Marc Vidal, David E Hill, Patrick Aloy, and Frederick P Roth. A framework for exhaustively mapping functional missense variants. Molecular Systems Biology, 13(12):957, December 2017. ISSN 1744-4292, 1744-4292. doi: 10.15252/msb.20177908. URL https://onlinelibrary.wiley.com/doi/10.15252/msb.20177908.
Jochen Weile, Nishka Kishore, Song Sun, Ranim Maaieh, Marta Verby, Roujia Li, Iosifina Fotiadou, Julia Kitaygorodsky, Yingzhou Wu, Alexander Holenstein, Céline Bürer, Linnea Blomgren, Shan Yang, Robert Nussbaum, Rima Rozen, David Watkins, Marinella Gebbia, Viktor Kozich, Michael Garton, D Sean Froese, and Frederick P Roth. Shifting landscapes of human MTHFR missense-variant effects. American Journal of Human Genetics, 108(7):1283–1300, July 2021.
Chenchun Weng, Andre J Faure, and Ben Lehner. The energetic and allosteric landscape for KRAS inhibition. December 2022.
Emily E. Wrenbeck, Laura R. Azouz, and Timothy A. Whitehead. Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded. Nature Communications, 8(1):15695, August 2017. ISSN 2041-1723. doi: 10.1038/ncomms15695. URL http://www.nature.com/articles/ncomms15695.