Silviase/jgov_v1.4_full_ann huggingface dataset:
さらに、PBDEs濃度（Deca-BDEを除く）と家族歴との関係については認められなかったが、親のアレルギ一群（AD）と非アレルギ一群（nonAD）群に対する児のアレルギ一皮膚炎発症の有無による層別化をしたところ、母親および父親の非アレルギ一群（nonAD）において、PBDEs濃度（Deca-BDEを除く）との関連が認められた。一方で、両親のアレルギ一群（AD）についてはPBDEs濃度（Deca-BDEを除く）との関連は見られなかった（図（1）-7）。

図(1)-7 PBDEs濃度と親・児アレルギ一性皮膚炎との関係※）Total PBDEsについては、Decaを除いた結果を示す。
図(1)-8に、PBDEs濃度（Deca-BDEを除く）の全体量とアレルギー性皮膚炎発症の閾値を示す。ここでは、これまで関連が認められた個々の同族体や異性体ではなく、全体量としてどの程度の曝露量によりアレルギー性皮膚炎を発症するかを検証するため、総PBDEs濃度（Deca-BDEを除く）の曝露量に対する域値の検討を行った。総PBDEs濃度（Deca-BDEを除く）15 pg/g-wet以下はアレルギー性皮膚炎の発症率が20%なのに対し、15 pg/g-wetを超えると45%が上昇していることが分かった。すなわち、総PBDEs濃度（Deca-BDEを除く）の曝露量が一定以上になると、アレルギー性皮膚炎を発症する児が増加する可能性が考えられた。ただし、本節の結果に記す総PBDEs濃度（Deca-BDEを除く）は、前節1）に記したとおり、現段階ではBDE-209（Deca）の解釈が困難なことから、BDE-209（Deca）の濃度を除いた値であることに留意願いたい。

図(1)-8 アレルギー性皮膚炎に対する総PBDEs濃度の閾値※）Total PBDEsについては、Decaを除いた結果を示す。
図(1)-9に本研究により得られたMonoからNonaおよび総PBDEs濃度（Deca-BDEを除く）の中央値を示す。本研究に得られた結果を考察すると、第一に、PBDEs濃度と生後7か月時アレルギ一性皮膚炎発症との関連が認められた同族体（図中、赤軸）であるTetra、Penta、Hepta、Octa、Nonaは総PBDEs濃度に占める割合が高いといえる。これまでの報告 $ ^{6)7)8)9} $ では、同族体毎の影響として、TetraおよびPentaは神経毒性、行動異常、内分泌攪乱および生殖毒性、Hexaは神経毒性、Octaは神経毒性と内分泌攪乱、Nonaは神経毒性と行動異常が報告され、特にTetraおよびPentaについては、毒性が高い可能性が報告されている。また、Pentaについては、高い蓄積性も懸念されており、PCB同様の蓄積性があると報告されている。これより、PBDE曝露量の高い同族体（Deca-BDEを除く）や、高い毒性、蓄積性を持つ同族体がアレルギ一性皮膚炎の発症と関連し、生後7か月時の発症を高める可能性が考えられる。

また、PBDEs濃度（Deca-BDEを除く）とアレルギー因子との関連について解析した結果（図(1)-7）から、母親のアレルギー歴により児を層別化すると、母親のアレルギー歴のない群においてPBDEs濃度（Deca-BDEを除く）を高めることが明らかとなった。

一方で、これまでPCBやダイオキシンについては、胎児期のPCBやダイオキシン曝露によるアレルギ一性皮膚炎の発症を高めることが報告されているが、その際にTh1/Th2のバランスからみてTh1優勢に傾くという結果や、曝露量と臍帯血IgEとの相関関係が認められないという報告がみられる。すなわち、これらの物質の曝露が、Th2に傾くといういわゆる免疫学的な機序を介したアレルギ一性皮膚炎の発症促進とは異なる形で、炎症を引き起こしている可能性が考えられ、今回得られた結果からもPBDEsにも同様の経路で発症を促進している可能性が考えられる。

図(1)-9 アレルギー性皮膚炎発症と関連のある同族体（中央値）と毒性※）Total PBDEs については、Decaを除いた結果を示す。
## 5 ．本研究により得られた成果

## （1） 科学的意義

PBDEsは曝露源として食物由来の経路に加え、ハウスダストなど生活環境の影響を受けやすい食品以外の曝露経路（外部曝露）の存在が疑わしいとされるが、PBDEsは、有機塩素化合物であるPCBsと比べ水酸化体へ代謝されやすく、蓄積性が低いとされる。しかしながら、すでにPBDEsの胎児への影響（内部曝露）が報告 $ ^{10} $ されていることからも本研究課題の追及は重要といえる。この背景には、母乳中に含まれるPBDE濃度の近年の急速な増加による影響 $ ^{11} $ 、日本人の脂肪組織内に蓄積するPBDEs濃度の増加による影響 $ ^{12} $ が懸念されるためである。

また、20名程度の小数例の先行研究で、児のアレルギー疾患の増悪度が授乳期間と関連している可能性を示すデータを得ており、特に乳幼児を中心にアトピ一性皮膚炎等のアレルギー疾患が増加している原因を追求する上でも本研究の科学的意義は高いといえよう。すなわち、継続的にアレルギー症状について調査し、PBDEsの曝露量とアレルギー疾患との関連性を統計的に解析した結果は、どの程度の曝露があればアレルギー疾患の発症や増悪に影響するかという定量的データを導き出すことを期待させる。

本研究の遂行により、臍帯中の臭素化難燃剤（PBDE）の曝露量と乳幼児期（生後7ヵ月後）までのアレルギー疾患との関連性を解析した結果、以下の事がわかった。

1．PBDEは、母体血・臍帯血・臍帯中の全ての検体で検出され、胎児期において、様々な同族体/異性体を含めPBDEに曝露されている。

2．PBDEの胎児曝露は、アトピ一性皮膚炎の発症・促進に何らかの関係がある可能性がある。

3．胎児期PBDE曝露によるアトピ一性皮膚炎の発症・促進は、炎症性を介しての可能性が示唆された。

4．乳幼児期のアレルギー疾患発症と化学物質曝露の関係は、胎児期曝露に加え母乳による乳児期曝露や遺伝的背景を加えた更なる解析が必要である。

## （２）環境政策への貢献

本研究課題となる「微量化学物質の胎児・新生児期曝露と乳幼児のアレルギー疾患の関連性に関する研究」による成果は、本研究代表者の所属する千葉ユニットが参画する“子どもの健康と環境に関する全国調査（エコチル調査）”における円滑な調査基盤を確立する上で重要な礎となった。すなわち、本研究の遂行により、エコチルを含むコホート研究では、リクルートならびにフォローアップ体制の十分な構築が必須で、調査方法（生体試料サンプリング等）における万全な対策が肝要であることは特筆されよう。

## 6 ．国際共同研究等の状況

Public Health” 国際連携プロジェクトとして、平成21年以降、ミネソタ大学（米国）、台湾大学（台湾）および仁済大学（韓国）と研究プロジェクトに対する協定を締結し、疫学調査である小児コホートを含むPublic Healthに関する研究・教育への取り組みの現状と今後の展望について
把握・周知することを第一義に、本研究遂行者ら（森、松野、戸高）が参画している。特に平成22年度については、松野が米国内の10万人規模の小児コホート調査拠点の一つであるミネソタ大学において、“Public Health”に関する学術交流を行い、米国内の“Public Health”への取り組みと教育方法を学んだ（日本学術振興会 組織的な若手研究者等海外派遣プログラム 慢性疾患の革新的包括マネジメント実現へ向けた国際的医薬看研究者育成プログラム）。

### 7. 研究成果の発表状況

## （1） 誌上発表

<論文（査読あり）>

特に記載すべき事項はない

<査読付論文に準ずる成果発表>

特に記載すべき事項はない

くその他誌上発表（査読なし）>

1) C Mori and E Todaka : Environmental contaminants and children's health Sustainable health science for future generations MARUZEN PLANET Co., Ltd., (2011) (ISBN:978-4-86345-077-6)

## （2） 口頭発表（学会等）

## 国際学会

1) C. Mori : 3rd WHO international conference on children's health and the environment

Busan, Korea, 2009

“Application of health examination system of total PCBs to prevent prenatal and lactational exposure of persistent organic pollutants (POPs).”

2) C. Mori, H. Fukata : 46^{th} Congress of the European societies of toxicology, Dresden, Germany, 2009

“Comparison of the blood levels of PCBs between fetuses and infants with longer lactational period in Japan.”
3) H. Fukata, S. Suzuki, N. Shimojo, Y. Kono and C. Mori : ISES 2009 annual conference: transforming exposure science in the 21st century. Minneapolis, Minnesota, USA, 2009 "Association between exposure to organochlorines and the occurrence of atopic dermatitis in Japanese infant."

4) C. Mori : ISES 2009 annual conference: transforming exposure science in the 21 $ ^{st} $ century. Minneapolis, Minnesota, USA, 2009

“Exposure assessment of PCBs in the current Japanese people.”

5) C. Mori: KIDS workshop 2009 in NIRS. Chiba, 2009

"Recent findings on effects of chemical exposure to children's health."

6) C. Mori, Y. Matsuno, H. Nakaoka, M. Hanazato, E. Todaka : ISES-ISEE 2010, Seoul, Korea, 2010

“Current fetal exposure level of endocrine disruptors, heavy metals and brominated flame retardants in Japan.”

7) Y. Igoshi, S. Ochiai, E. Todaka, Y. Matsuno, S. Suzuki, N. Shimojo, Y. Kohno and C. Mori : Society of Toxicology (SOT) 50th Anniversary Annual Meeting, Washington, D.C. USA, 2011

“Correlation between polybrominated diphenyl ethers (PBDEs) and persistent organic pollutants (POPs) or heavy metals detected in umbilical cords.”

8) Y. Matsuno, T. Fujisaki, N. Nakamura, H. Nakaoka, M. Hanazato, E. Todaka and C. Mori: Dioxin 2011 31st International Symposium on Halogenated Persistent Organic Pollutants, Brussels, Belgium, 2011

“Maternal and fetal exposure levels of congeners of PCBs and polybrominated diphenyl ethers (PBDEs) in human.”

9) Y. Matsuno, C. Mori, T. Fujisaki, E. Todaka, M. Shimoda, H. Nakaoka, M. Hanazato and N. Nakamura : ISEE 2011 23rd Annual Conference, Barcelona, Spain, 2011

"Transfer rate difference according to the congeners and isomers should be considered in risk assessment of fetal exposure to PBDEs and POPs."

10) C. Mori, N. Nakamura, T. Fujisaki, E. Todaka, Y. Matsuno, M. Shimoda, H. Nakaoka and M. Hanazato : PARIS Eurotox 2011 47th Congress of the European Societies of Toxicology, Paris, France, 2011
“Correlation between molecular weight and transfer rate of congeners of dioxins, PCBs and polybrominated diphenyl ethers (PBDEs) from mother to fetus through placenta in human.”

## 国内学会

1） 深田秀樹、鈴木修一、下條直樹、河野陽一、森 千里：第18回日本臨床環境医学会学術集会(2009)

「小児の有機塩素系化学物質曝露とアレルギー疾患との関連性について」

2）森千里：第16回日本免疫毒性学会学術学会（2009）

「胎児の複合汚染とアレルギー疾患との関連、そして次世代の健康を守るための化学物質

の健康診断システム(シンポジウム「子どもと免疫」]

## （3） 出願特許

特に記載すべき事項はない

（4）シンポジウム、セミナーの開催（主催のもの）

特に記載すべき事項はない

（５）マスコミ等への公表・報道等

特に記載すべき事項はない

(6) その他

特に記載すべき事項はない

### 8 \. 引用文献

1）川城由紀子，松野義晴，深田秀樹，森千里：臭素系難燃剤による胎児への影響に関する最近の知見．医学のあゆみ，228，785-786(2009)

2) McDonald T. A.: A perspective on the potential health risks of PBDEs. Chemosphere, 46:745-755 (2002)
3) Watanabe I, Sakai S. : Environmental release and behavior of brominated flame retardants. Environ Int. , 29 : 665-682 (2003)

4) Ohta S, Ishizuka D, Nishimura H, Nakao T, Aozasa O, Shimizzu Y, Ochiai F, Kida T, Nishi M, Miyata H. : Comparison of polybrominated diphenyl ethers in fish, vegetables, and meats and levels in human milk of nursing women in Japan. Chemosphere. , 46 : 689-696 (2002)

5) Wu N, Herrmann T, Paepke O, Tickner J, Hale R, Harvey LE, La Guardia M, McClean MD, Webster TF. : Human exposure to PBDEs: associations of PBDE body burdens with food consumption and house dust concentrations. Environ Sci Technol. , 41 : 1584-1589 (2007)

6) Lilienthal, H., Hack, A., Roth-Härer, A., Grande, S.W., Talsness, C.E.: Effects of Developmental Exposure to 2,2',4,4',5-Pentabromodiphenyl Ether (PBDE-99) on Sex Steroids, Sexual Development, and Sexually Dimorphic Behavior in Rats. Environmental Health Perspectives 114 : 194-201 (2006)

7) Viberg, H., Johansson, N., Fredriksson, A., Eriksson, J., Marsh, G., Eriksson, P.: Neonatal exposure to higher brominated diphenyl ethers, hepta-, octa-, or nonabromodiphenyl ether, impairs spontaneous behavior and learning and memory functions of adult mice. Toxicol Sci 92, 211-218 (2006)

8) Shao, J., White, C.C., Dabrowski, M.J., Kavanagh, T.J., Eckert, M.L., Gallagher, E.P.: The Role of Mitochondrial and Oxidative Injury in BDE 47 Toxicity to Human Fetal Liver Hematopoietic Stem Cells. Toxicological Sciences 101, 81-90 (2007)

9) He, W., He, P., Wang, A., Xia, T., Xu, B., Chen, X. :2008. Effects of PBDE-47 on cytotoxicity and genotoxicity in human neuroblastoma cells in vitro. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 649, 62-70 (2008)

10) Chao HR, Wang SL, Lee WJ, Wang YF, Päpke O. : Levels of polybrominated diphenyl ethers (PBDEs) in breast milk from central Taiwan and their relation to infant birth outcome and maternal menstruation effects. Environ Int., 33: 239-245 (2007)

11) PO Darnerud, GS Eriksen, T Jóhannesson, P B Larsen, Viluksela : Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environ Health Perspect.

109 (Suppl 1) : 49-68(2001)

12) Choi JW, Fujimaki TS, Kitamura K, Hashimoto S, Ito H, Suzuki N, Sakai S, Morita M. Polybrominated dibenzo-p-dioxins, dibenzofurans, and diphenyl ethers in Japanese human adipose tissue. Environ Sci Technol. 37: 817-821 (2003)
参考資料(1) 測定結果 試料重量あたりのPBDEs濃度（pg/g-wet） ID-1～ID5

No. (ID-0)	000001	000002	000003	000004	000005
試料名	臍帶2	臍帶3	臍帶4	臍帶7	臍帶9
試料量g	5.10	5.25	5.03	5.25	5.03
脂肪量mg/g	1.10	1.10	1.41	0.95	0.90
濃度pg/g-wet	定量下限值	濃度pg/g-wet	定量下限值	濃度pg/g-wet	定量下限值	濃度pg/g-wet	定量下限值	濃度pg/g-wet	定量下限值
BDE-3	N.D.	2.1	N.D.	1.8	N.D.	2.2	N.D.	2.0	N.D.	1.9
BDE-7	N.D.	0.49	N.D.	0.41	N.D.	0.53	N.D.	0.45	N.D.	0.42
BDE-15	N.D.	0.28	N.D.	0.24	N.D.	0.30	N.D.	0.26	N.D.	0.24
BDE-17	N.D.	0.33	N.D.	0.27	N.D.	0.33	N.D.	0.27	N.D.	0.27
BDE-28	N.D.	0.33	N.D.	0.27	N.D.	0.33	N.D.	0.27	N.D.	0.27
BDE-49	N.D.	0.75	N.D.	0.60	N.D.	0.82	N.D.	0.64	N.D.	0.59
BDE-71	N.D.	0.59	N.D.	0.48	N.D.	0.65	N.D.	0.51	N.D.	0.47
BDE-47	1.4	0.46	0.88	0.37	1.2	0.51	0.97	0.39	0.62	0.37
BDE-66	N.D.	0.94	N.D.	0.75	N.D.	1.0	N.D.	0.80	N.D.	0.75
BDE-77	N.D.	0.59	N.D.	0.47	N.D.	0.64	N.D.	0.50	N.D.	0.47
BDE-100	N.D.	0.32	N.D.	0.25	N.D.	0.34	N.D.	0.26	N.D.	0.26
BDE-119	N.D.	0.56	N.D.	0.43	N.D.	0.58	N.D.	0.45	N.D.	0.45
BDE-99	N.D.	0.49	0.56	0.38	0.52	0.51	N.D.	0.39	N.D.	0.39
BDE-85	N.D.	0.68	N.D.	0.53	N.D.	0.71	N.D.	0.55	N.D.	0.55
BDE-126	N.D.	0.57	N.D.	0.44	N.D.	0.59	N.D.	0.46	N.D.	0.46
BDE-154	N.D.	0.76	N.D.	0.64	N.D.	0.86	N.D.	0.64	N.D.	0.61
BDE-153	4.4	1.2	N.D.	0.98	N.D.	1.3	N.D.	0.95	N.D.	0.95
BDE-138	N.D.	1.4	N.D.	1.2	N.D.	1.6	N.D.	1.2	N.D.	1.1
BDE-156	N.D.	2.7	N.D.	2.3	N.D.	3.1	N.D.	2.2	N.D.	2.2
BDE-184	N.D.	0.43	N.D.	0.39	N.D.	0.57	N.D.	0.36	N.D.	0.36
BDE-183	N.D.	0.43	N.D.	0.40	N.D.	0.57	N.D.	0.37	N.D.	0.36
BDE-191	N.D.	0.52	N.D.	0.47	N.D.	0.68	N.D.	0.44	N.D.	0.43
BDE-197	N.D.	1.0	N.D.	0.98	N.D.	1.2	N.D.	0.90	N.D.	0.82
BDE-196	N.D.	1.2	N.D.	1.1	N.D.	1.4	N.D.	1.0	N.D.	0.96
BDE-207	N.D.	2.4	N.D.	2.1	N.D.	2.4	N.D.	1.7	3.3	1.6
BDE-206	N.D.	7.0	N.D.	6.0	N.D.	6.9	N.D.	5.0	6.3	4.7
BDE-209	51	29	24	22	81	16	73	14	260	9.4
MonoBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DiBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TriBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TetraBDE	1.4	0.88	1.2	0.97	0.62
PentaBDE	N.D.	0.56	0.52	N.D.	N.D.
HexaBDE	4.4	N.D.	N.D.	N.D.	N.D.
HeptaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
OctaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
NonaBDE	N.D.	N.D.	N.D.	N.D.	9.6
DecaBDE	51	24	81	73	260
TotalPBDEs	57	25	83	74	270

定量下限未満は “N.D” と表示した。
参考資料(2) 測定結果 試料重量あたりのPBDEs濃度（pg/g-wet） ID-6～ID-10

No. (ID-0)	000006	000007	000008	000009	000010
試料名	臍帶13	臍帶15	臍帶16	臍帶17	臍帶18
試料量g	5.06	5.04	4.65	5.16	5.08
脂肪量mg/g	0.95	0.54	0.95	1.88	0.93
濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值
BDE-3	N.D.	4.2	N.D.	2.8	N.D.	1.7	N.D.	2.2	N.D.	3.8
BDE-7	N.D.	0.85	N.D.	0.62	N.D.	0.35	N.D.	0.54	N.D.	0.72
BDE-15	N.D.	0.49	N.D.	0.36	N.D.	0.20	N.D.	0.31	N.D.	0.42
BDE-17	N.D.	0.56	N.D.	0.43	N.D.	0.22	N.D.	0.34	N.D.	0.44
BDE-28	N.D.	0.56	N.D.	0.44	N.D.	0.22	N.D.	0.34	N.D.	0.45
BDE-49	N.D.	1.2	N.D.	0.96	N.D.	0.50	N.D.	0.74	N.D.	0.98
BDE-71	N.D.	0.99	N.D.	0.76	N.D.	0.40	N.D.	0.59	N.D.	0.78
BDE-47	1.1	0.77	1.4	0.59	0.91	0.31	1.0	0.46	1.1	0.61
BDE-66	N.D.	1.6	N.D.	1.2	N.D.	0.63	N.D.	0.93	N.D.	1.2
BDE-77	N.D.	0.98	N.D.	0.75	N.D.	0.39	N.D.	0.58	N.D.	0.77
BDE-100	N.D.	0.51	N.D.	0.40	N.D.	0.21	N.D.	0.30	N.D.	0.41
BDE-119	N.D.	0.88	N.D.	0.70	N.D.	0.36	N.D.	0.51	N.D.	0.70
BDE-99	N.D.	0.77	N.D.	0.61	0.32	0.31	N.D.	0.45	N.D.	0.62
BDE-85	N.D.	1.1	N.D.	0.85	N.D.	0.44	N.D.	0.63	N.D.	0.86
BDE-126	N.D.	0.89	N.D.	0.71	N.D.	0.37	N.D.	0.52	N.D.	0.72
BDE-154	N.D.	1.3	N.D.	0.99	N.D.	0.50	N.D.	0.74	N.D.	0.95
BDE-153	N.D.	1.9	N.D.	1.5	N.D.	0.74	N.D.	1.1	N.D.	1.4
BDE-138	N.D.	2.3	N.D.	1.8	N.D.	0.90	N.D.	1.3	N.D.	1.7
BDE-156	N.D.	4.4	N.D.	3.4	N.D.	1.7	N.D.	2.5	N.D.	3.2
BDE-184	N.D.	0.72	N.D.	0.56	N.D.	0.27	N.D.	0.40	N.D.	0.52
BDE-183	N.D.	0.73	N.D.	0.57	N.D.	0.28	N.D.	0.41	N.D.	0.53
BDE-191	N.D.	0.87	N.D.	0.68	N.D.	0.33	N.D.	0.49	N.D.	0.63
BDE-197	N.D.	1.9	N.D.	1.4	N.D.	0.59	N.D.	0.89	N.D.	1.2
BDE-196	N.D.	2.2	N.D.	1.6	N.D.	0.69	N.D.	1.0	N.D.	1.4
BDE-207	N.D.	3.6	N.D.	2.6	N.D.	1.2	N.D.	1.7	N.D.	2.1
BDE-206	N.D.	10	N.D.	7.6	N.D.	3.4	N.D.	5.0	N.D.	6.2
BDE-209	49	26	39	21	65	9.5	73	13	26	16
MonoBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DiBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TriBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TetraBDE	1.1	1.4	0.91	1.0	1.1
PentaBDE	N.D.	N.D.	0.32	N.D.	N.D.
HexaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HeptaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
OctaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
NonaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DecaBDE	49	39	65	73	26
Total
PBDEs	50	40	66	74	27

定量下限未満は“N.D”と表示した。
参考資料(3) 測定結果 試料重量あたりのPBDEs濃度（pg/g-wet） ID-11～ID-15

No. (ID-0)	000011	000012	000013	000014	000015
試料名	臍帶19	臍帶21	臍帶22	臍帶23	臍帶25
試料量g	4.76	4.76	5.08	5.21	5.14
脂肪量mg/g	0.90	1.39	0.89	0.81	1.19
濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值
BDE-3	N.D.	2.5	N.D.	2.5	N.D.	2.7	N.D.	2.4	N.D.	2.7
BDE-7	N.D.	0.52	N.D.	0.53	N.D.	0.53	N.D.	0.56	N.D.	0.50
BDE-15	N.D.	0.30	N.D.	0.31	0.65	0.30	N.D.	0.32	N.D.	0.29
BDE-17	N.D.	0.34	N.D.	0.32	N.D.	0.31	N.D.	0.38	N.D.	0.29
BDE-28	N.D.	0.34	N.D.	0.32	3.9	0.31	N.D.	0.39	N.D.	0.30
BDE-49	N.D.	0.77	N.D.	0.70	1.1	0.66	N.D.	0.84	N.D.	0.61
BDE-71	N.D.	0.61	N.D.	0.56	N.D.	0.52	N.D.	0.67	N.D.	0.49
BDE-47	0.82	0.47	0.96	0.43	39	0.41	0.72	0.52	1.2	0.38
BDE-66	N.D.	0.96	N.D.	0.88	1.0	0.82	N.D.	1.1	N.D.	0.77
BDE-77	N.D.	0.60	N.D.	0.55	N.D.	0.52	N.D.	0.66	N.D.	0.48
BDE-100	N.D.	0.30	N.D.	0.28	2.2	0.28	N.D.	0.35	N.D.	0.25
BDE-119	N.D.	0.52	N.D.	0.49	N.D.	0.49	N.D.	0.60	N.D.	0.43
BDE-99	N.D.	0.45	N.D.	0.43	5.1	0.43	N.D.	0.53	0.43	0.38
BDE-85	N.D.	0.63	N.D.	0.60	N.D.	0.60	N.D.	0.74	N.D.	0.53
BDE-126	N.D.	0.53	N.D.	0.50	N.D.	0.50	N.D.	0.62	N.D.	0.44
BDE-154	N.D.	0.73	N.D.	0.71	N.D.	0.71	N.D.	0.86	N.D.	0.63
BDE-153	N.D.	1.1	N.D.	1.0	N.D.	1.0	N.D.	1.3	N.D.	0.93
BDE-138	N.D.	1.3	N.D.	1.2	N.D.	1.2	N.D.	1.6	N.D.	1.1
BDE-156	N.D.	2.5	N.D.	2.4	N.D.	2.4	N.D.	3.0	N.D.	2.1
BDE-184	N.D.	0.40	N.D.	0.37	N.D.	0.43	N.D.	0.47	N.D.	0.35
BDE-183	N.D.	0.41	N.D.	0.38	N.D.	0.43	N.D.	0.48	N.D.	0.36
BDE-191	N.D.	0.49	N.D.	0.45	N.D.	0.52	N.D.	0.57	N.D.	0.43
BDE-197	N.D.	0.95	N.D.	0.84	N.D.	0.99	N.D.	1.2	N.D.	0.83
BDE-196	N.D.	1.1	N.D.	0.98	N.D.	1.2	N.D.	1.4	N.D.	0.96
BDE-207	N.D.	1.9	N.D.	1.6	N.D.	1.6	N.D.	2.4	N.D.	1.6
BDE-206	N.D.	5.4	N.D.	4.7	N.D.	4.7	N.D.	7.0	N.D.	4.5
BDE-209	67	17	52	15	35	11	150	18	65	12
MonoBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DiBDE	N.D.	N.D.	0.65	N.D.	N.D.
TriBDE	N.D.	N.D.	3.9	N.D.	N.D.
TetraBDE	0.82	0.96	41	0.72	1.2
PentaBDE	N.D.	N.D.	7.3	N.D.	0.43
HexaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HeptaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
OctaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
NonaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DecaBDE	67	52	35	150	65
Total
PBDEs	68	53	88	150	67

定量下限未満は “N.D.” と表示した。
参考資料(4) 測定結果 試料重量あたりのPBDEs濃度（pg/g-wet） ID-16～ID-20

No. (ID-0)	000016	000017	000018	000019	000020
試料名	臍帶28	臍帶29	臍帶32	臍帶33	臍帶34
試料量g	5.13	5.11	5.11	5.05	5.07
脂肪量mg/g	0.70	1.00	1.19	1.05	0.89
濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值
BDE-3	N.D.	4.4	N.D.	2.2	N.D.	2.3	N.D.	2.6	N.D.	2.5
BDE-7	N.D.	0.92	N.D.	0.49	N.D.	0.47	N.D.	0.55	N.D.	0.54
BDE-15	N.D.	0.54	N.D.	0.28	N.D.	0.27	N.D.	0.32	N.D.	0.31
BDE-17	N.D.	0.56	N.D.	0.32	N.D.	0.29	N.D.	0.38	N.D.	0.34
BDE-28	N.D.	0.57	N.D.	0.33	N.D.	0.30	N.D.	0.38	N.D.	0.35
BDE-49	N.D.	1.2	N.D.	0.71	N.D.	0.62	N.D.	0.83	N.D.	0.76
BDE-71	N.D.	0.97	N.D.	0.57	N.D.	0.49	N.D.	0.66	N.D.	0.60
BDE-47	2.7	0.76	1.0	0.44	1.3	0.38	N.D.	0.51	1.1	0.47
BDE-66	N.D.	1.5	N.D.	0.90	N.D.	0.78	N.D.	1.0	N.D.	0.95
BDE-77	N.D.	0.96	N.D.	0.56	N.D.	0.49	N.D.	0.65	N.D.	0.60
BDE-100	N.D.	0.53	N.D.	0.28	N.D.	0.26	N.D.	0.34	N.D.	0.34
BDE-119	N.D.	0.92	N.D.	0.49	N.D.	0.45	N.D.	0.58	N.D.	0.59
BDE-99	N.D.	0.81	0.63	0.43	0.45	0.39	N.D.	0.51	N.D.	0.51
BDE-85	N.D.	1.1	N.D.	0.60	N.D.	0.55	N.D.	0.71	N.D.	0.72
BDE-126	N.D.	0.94	N.D.	0.50	N.D.	0.46	N.D.	0.59	N.D.	0.60
BDE-154	N.D.	1.2	N.D.	0.72	N.D.	0.65	N.D.	0.83	N.D.	0.79
BDE-153	N.D.	1.9	N.D.	1.1	N.D.	1.0	N.D.	1.2	N.D.	1.2
BDE-138	N.D.	2.3	N.D.	1.3	N.D.	1.2	N.D.	1.5	N.D.	1.4
BDE-156	N.D.	4.3	N.D.	2.4	N.D.	2.3	N.D.	2.8	N.D.	2.7
BDE-184	N.D.	0.69	N.D.	0.40	N.D.	0.38	N.D.	0.48	N.D.	0.45
BDE-183	N.D.	0.70	N.D.	0.40	N.D.	0.38	N.D.	0.49	N.D.	0.46
BDE-191	N.D.	0.84	N.D.	0.48	N.D.	0.46	N.D.	0.59	N.D.	0.55
BDE-197	N.D.	1.6	N.D.	0.94	N.D.	0.86	N.D.	1.2	N.D.	1.1
BDE-196	N.D.	1.9	N.D.	1.1	N.D.	1.0	N.D.	1.3	N.D.	1.3
BDE-207	N.D.	3.2	N.D.	1.7	N.D.	1.7	N.D.	2.6	N.D.	1.9
BDE-206	N.D.	9.2	N.D.	5.1	N.D.	5.0	N.D.	7.7	N.D.	5.6
BDE-209	93	28	65	16	53	17	42	28	100	11
MonoBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DiBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TriBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TetraBDE	2.7	1.0	1.3	N.D.	1.1
PentaBDE	N.D.	0.63	0.45	N.D.	N.D.
HexaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HeptaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
OctaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
NonaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DecaBDE	93	65	53	42	100
Total
PBDEs	96	67	55	42	100

定量下限未満は “N.D.” と表示した。
参考資料(5) 測定結果 試料重量あたりのPBDEs濃度（pg/g-wet） ID-21～ID-25

No. (ID-0)	000021	000022	000023	000024	000025
試料名	臍帶35	臍帶36	臍帶37	臍帶40	臍帶42
試料量g	4.83	5.10	4.97	5.04	4.87
脂肪量mg/g	1.78	1.65	0.95	0.99	0.95
濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值
BDE-3	N.D.	2.9	N.D.	1.9	N.D.	2.2	N.D.	2.8	N.D.	2.2
BDE-7	N.D.	0.58	N.D.	0.39	N.D.	0.51	N.D.	0.57	N.D.	0.48
BDE-15	N.D.	0.33	N.D.	0.23	N.D.	0.29	N.D.	0.33	N.D.	0.28
BDE-17	N.D.	0.42	N.D.	0.25	N.D.	0.28	N.D.	0.39	N.D.	0.33
BDE-28	N.D.	0.43	N.D.	0.25	N.D.	0.29	N.D.	0.39	N.D.	0.33
BDE-49	N.D.	0.95	N.D.	0.55	N.D.	0.67	N.D.	0.84	N.D.	0.70
BDE-71	N.D.	0.75	N.D.	0.43	N.D.	0.53	N.D.	0.67	N.D.	0.56
BDE-47	0.84	0.59	0.65	0.34	0.70	0.42	0.75	0.52	N.D.	0.43
BDE-66	N.D.	1.2	N.D.	0.69	N.D.	0.85	N.D.	1.1	N.D.	0.88
BDE-77	N.D.	0.75	N.D.	0.43	N.D.	0.53	N.D.	0.66	N.D.	0.55
BDE-100	N.D.	0.37	N.D.	0.22	N.D.	0.26	N.D.	0.37	N.D.	0.30
BDE-119	N.D.	0.65	N.D.	0.38	N.D.	0.45	N.D.	0.64	N.D.	0.51
BDE-99	N.D.	0.57	N.D.	0.33	N.D.	0.39	N.D.	0.56	N.D.	0.45
BDE-85	N.D.	0.79	N.D.	0.46	N.D.	0.55	N.D.	0.78	N.D.	0.63
BDE-126	N.D.	0.66	N.D.	0.38	N.D.	0.46	N.D.	0.65	N.D.	0.52
BDE-154	N.D.	0.96	N.D.	0.55	N.D.	0.68	N.D.	0.91	N.D.	0.73
BDE-153	N.D.	1.4	N.D.	0.83	N.D.	0.90	N.D.	1.3	N.D.	1.1
BDE-138	N.D.	1.7	N.D.	1.0	N.D.	1.1	N.D.	1.6	N.D.	1.3
BDE-156	N.D.	3.2	N.D.	1.9	N.D.	2.1	N.D.	3.0	N.D.	2.5
BDE-184	N.D.	0.51	N.D.	0.31	N.D.	0.35	N.D.	0.49	N.D.	0.41
BDE-183	N.D.	0.52	N.D.	0.32	N.D.	0.35	N.D.	0.50	N.D.	0.42
BDE-191	N.D.	0.62	N.D.	0.38	N.D.	0.42	N.D.	0.59	N.D.	0.50
BDE-197	N.D.	1.2	N.D.	0.70	N.D.	0.72	N.D.	1.0	N.D.	0.91
BDE-196	N.D.	1.4	N.D.	0.81	N.D.	0.84	N.D.	1.2	N.D.	1.1
BDE-207	N.D.	2.6	N.D.	1.3	N.D.	1.1	N.D.	1.7	N.D.	1.6
BDE-206	N.D.	7.7	N.D.	3.9	N.D.	3.3	N.D.	5.0	N.D.	4.5
BDE-209	45	28	40	12	44	7.7	47	12	30	13
MonoBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DiBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TriBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TetraBDE	0.84	0.65	0.70	0.75	N.D.
PentaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HexaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HeptaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
OctaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
NonaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DecaBDE	45	40	44	47	30
Total
PBDEs	46	41	45	48	30

定量下限未満は “N.D.” と表示した。
参考資料(6) 測定結果 試料重量あたりのPBDEs濃度（pg/g-wet） ID-26～ID-30

No. (ID-0)	000026	000027	000028	000029	000030
試料名	臍帶44	臍帶47	臍帶51	臍帶55	臍帶56
試料量g	4.79	5.03	5.01	5.21	5.06
脂肪量mg/g	0.69	1.39	1.64	1.11	0.75
濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值
BDE-3	N.D.	2.8	N.D.	2.8	N.D.	2.4	N.D.	2.1	N.D.	2.3
BDE-7	N.D.	0.61	N.D.	0.56	N.D.	0.49	N.D.	0.39	N.D.	0.46
BDE-15	N.D.	0.35	N.D.	0.32	N.D.	0.29	N.D.	0.23	N.D.	0.27
BDE-17	N.D.	0.44	N.D.	0.37	N.D.	0.31	N.D.	0.24	N.D.	0.30
BDE-28	N.D.	0.44	N.D.	0.38	N.D.	0.31	N.D.	0.24	N.D.	0.31
BDE-49	N.D.	0.98	N.D.	0.86	N.D.	0.68	N.D.	0.50	N.D.	0.64
BDE-71	N.D.	0.78	N.D.	0.68	N.D.	0.54	N.D.	0.40	N.D.	0.51
BDE-47	N.D.	0.61	1.1	0.53	0.87	0.42	0.78	0.31	1.0	0.40
BDE-66	N.D.	1.2	N.D.	1.1	N.D.	0.86	N.D.	0.63	N.D.	0.81
BDE-77	N.D.	0.77	N.D.	0.68	N.D.	0.54	N.D.	0.39	N.D.	0.51
BDE-100	N.D.	0.39	N.D.	0.38	N.D.	0.31	N.D.	0.23	N.D.	0.28
BDE-119	N.D.	0.68	N.D.	0.66	N.D.	0.53	N.D.	0.39	N.D.	0.49
BDE-99	N.D.	0.59	N.D.	0.58	N.D.	0.47	N.D.	0.35	N.D.	0.43
BDE-85	N.D.	0.83	N.D.	0.81	N.D.	0.65	N.D.	0.48	N.D.	0.60
BDE-126	N.D.	0.69	N.D.	0.67	N.D.	0.54	N.D.	0.40	N.D.	0.50
BDE-154	N.D.	0.97	N.D.	0.87	N.D.	0.74	N.D.	0.56	N.D.	0.67
BDE-153	N.D.	1.4	N.D.	1.2	N.D.	1.1	N.D.	0.86	N.D.	1.0
BDE-138	N.D.	1.7	N.D.	1.5	N.D.	1.3	N.D.	1.0	N.D.	1.2
BDE-156	N.D.	3.2	N.D.	2.8	N.D.	2.6	N.D.	2.0	N.D.	2.3
BDE-184	N.D.	0.52	N.D.	0.47	N.D.	0.41	N.D.	0.32	N.D.	0.39
BDE-183	N.D.	0.53	N.D.	0.47	N.D.	0.42	N.D.	0.32	N.D.	0.40
BDE-191	N.D.	0.63	N.D.	0.57	N.D.	0.50	N.D.	0.38	N.D.	0.48
BDE-197	N.D.	1.2	N.D.	0.94	N.D.	0.76	N.D.	0.70	N.D.	0.95
BDE-196	N.D.	1.4	N.D.	1.1	N.D.	0.88	N.D.	0.81	N.D.	1.1
BDE-207	N.D.	2.1	N.D.	1.6	N.D.	1.3	N.D.	1.1	N.D.	1.8
BDE-206	N.D.	6.0	N.D.	4.6	N.D.	3.9	N.D.	3.3	N.D.	5.3
BDE-209	77	17	53	15	53	12	51	12	66	19
MonoBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DiBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TriBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TetraBDE	N.D.	1.1	0.87	0.78	1.0
PentaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HexaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HeptaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
OctaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
NonaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DecaBDE	77	53	53	51	66
Total
PBDEs	77	54	54	52	67

定量下限未満は “N.D.” と表示した。
参考資料(7) 測定結果 試料重量あたりのPBDEs濃度（pg/g-wet） ID-31～ID-35

No. (ID-0)	000031	000032	000033	000034	000035
試料名	臍帶59	臍帶61	臍帶64	臍帶68	臍帶81
試料量g	5.06	5.02	5.10	5.03	5.05
脂肪量mg/g	0.77	1.45	0.71	1.57	1.11
濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值	濃度
pg/g-
wet	定量
下限值
BDE-3	N.D.	2.3	N.D.	2.3	N.D.	6.6	N.D.	2.4	N.D.	2.8
BDE-7	N.D.	0.43	N.D.	0.43	N.D.	0.78	N.D.	0.44	N.D.	0.54
BDE-15	N.D.	0.25	N.D.	0.25	N.D.	0.45	N.D.	0.25	N.D.	0.31
BDE-17	N.D.	0.26	N.D.	0.28	N.D.	0.48	N.D.	0.28	N.D.	0.33
BDE-28	N.D.	0.26	N.D.	0.29	N.D.	0.49	N.D.	0.28	N.D.	0.33
BDE-49	N.D.	0.57	N.D.	0.62	N.D.	1.1	N.D.	0.58	N.D.	0.68
BDE-71	N.D.	0.45	N.D.	0.49	N.D.	0.84	N.D.	0.46	N.D.	0.54
BDE-47	1.0	0.35	0.95	0.38	1.0	0.65	1.2	0.36	0.74	0.42
BDE-66	N.D.	0.71	N.D.	0.77	N.D.	1.3	N.D.	0.73	N.D.	0.86
BDE-77	N.D.	0.45	N.D.	0.48	N.D.	0.83	N.D.	0.46	N.D.	0.54
BDE-100	N.D.	0.22	N.D.	0.26	N.D.	0.43	N.D.	0.25	N.D.	0.31
BDE-119	N.D.	0.38	N.D.	0.44	N.D.	0.74	N.D.	0.43	N.D.	0.53
BDE-99	N.D.	0.33	N.D.	0.39	N.D.	0.64	N.D.	0.38	N.D.	0.46
BDE-85	N.D.	0.46	N.D.	0.54	N.D.	0.90	N.D.	0.53	N.D.	0.65
BDE-126	N.D.	0.38	N.D.	0.45	N.D.	0.75	N.D.	0.44	N.D.	0.54
BDE-154	N.D.	0.56	N.D.	0.63	N.D.	1.0	N.D.	0.61	N.D.	0.76
BDE-153	N.D.	0.80	N.D.	0.93	N.D.	1.5	N.D.	0.91	N.D.	1.1
BDE-138	N.D.	0.97	N.D.	1.1	N.D.	1.8	N.D.	1.1	N.D.	1.3
BDE-156	N.D.	1.8	N.D.	2.1	N.D.	3.4	N.D.	2.1	N.D.	2.5
BDE-184	N.D.	0.31	N.D.	0.36	N.D.	0.54	N.D.	0.35	N.D.	0.42
BDE-183	N.D.	0.31	N.D.	0.36	N.D.	0.55	N.D.	0.35	N.D.	0.43
BDE-191	N.D.	0.37	N.D.	0.43	N.D.	0.65	N.D.	0.42	N.D.	0.51
BDE-197	N.D.	0.75	N.D.	0.83	N.D.	1.3	N.D.	0.84	N.D.	0.99
BDE-196	N.D.	0.87	N.D.	0.96	N.D.	1.5	N.D.	0.97	N.D.	1.1
BDE-207	N.D.	1.2	N.D.	1.4	N.D.	2.2	N.D.	1.6	N.D.	2.1
BDE-206	N.D.	3.6	N.D.	4.1	N.D.	6.5	N.D.	4.7	N.D.	6.0
BDE-209	61	6.6	42	12	98	13	32	15	48	21
MonoBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DiBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TriBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TetraBDE	1.0	0.95	1.0	1.2	0.74
PentaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HexaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HeptaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
OctaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
NonaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DecaBDE	61	42	98	32	48
Total
PBDEs	62	43	99	33	49

定量下限未満は “N.D.” と表示した。