Silviase/jgov_v1.4_full_ann huggingface dataset:
参考資料(31) 測定結果 脂肪重量あたりのPBDEs濃度（ng/g-fat） ID-61～ID-65

No. (ID-0)	000061	000062	000063	000064	000065
試料名	臍帶71	臍帶73	臍帶75	臍帶79	臍帶80
試料量g	5.05	5.04	5.03	5.01	5.09
脂肪量mg/g	0.97	1.47	0.78	0.68	0.86
濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值
BFR-3	N.D.	2.9	N.D.	1.8	N.D.	3.6	N.D.	5.0	N.D.	2.5
BFR-7	N.D.	0.57	N.D.	0.32	N.D.	0.64	N.D.	0.93	N.D.	0.48
BFR-15	N.D.	0.33	N.D.	0.19	N.D.	0.38	N.D.	0.54	N.D.	0.28
BFR-17	N.D.	0.57	N.D.	0.32	N.D.	0.67	N.D.	0.91	N.D.	0.48
BFR-28	N.D.	0.58	N.D.	0.32	N.D.	0.68	N.D.	0.93	N.D.	0.49
BFR-49	N.D.	1.0	N.D.	0.58	N.D.	1.2	N.D.	1.7	N.D.	0.89
BFR-71	N.D.	0.77	N.D.	0.43	N.D.	0.92	N.D.	1.3	N.D.	0.66
BFR-47	6.4	0.63	1.1	0.35	2.5	0.75	2.1	1.1	1.2	0.54
BFR-66	N.D.	1.4	N.D.	0.77	N.D.	1.6	N.D.	2.3	N.D.	1.2
BFR-77	N.D.	0.89	N.D.	0.50	N.D.	1.1	N.D.	1.5	N.D.	0.77
BFR-100	1.5	0.46	N.D.	0.26	N.D.	0.59	N.D.	0.83	N.D.	0.38
BFR-119	N.D.	0.82	N.D.	0.47	N.D.	1.1	N.D.	1.5	N.D.	0.68
BFR-99	1.8	0.73	0.47	0.42	N.D.	0.95	N.D.	1.3	0.71	0.61
BFR-85	N.D.	1.1	N.D.	0.63	N.D.	1.4	N.D.	2.0	N.D.	0.92
BFR-126	N.D.	0.94	N.D.	0.53	N.D.	1.2	N.D.	1.7	N.D.	0.78
BFR-154	N.D.	1.2	N.D.	0.64	N.D.	1.4	N.D.	2.0	N.D.	0.93
BFR-153	N.D.	1.8	N.D.	0.96	N.D.	2.0	N.D.	3.0	N.D.	1.4
BFR-138	N.D.	2.4	N.D.	1.3	N.D.	2.7	N.D.	4.1	N.D.	1.9
BFR-156	N.D.	4.3	N.D.	2.3	N.D.	4.9	N.D.	7.4	N.D.	3.5
BFR-184	N.D.	0.77	N.D.	0.42	N.D.	0.89	N.D.	1.3	N.D.	0.62
BFR-183	N.D.	0.79	N.D.	0.43	N.D.	0.92	N.D.	1.4	N.D.	0.64
BFR-191	N.D.	1.0	N.D.	0.54	N.D.	1.2	N.D.	1.7	N.D.	0.81
BFR-197	N.D.	1.8	N.D.	0.89	N.D.	2.0	N.D.	3.1	N.D.	1.3
BFR-196	N.D.	2.0	N.D.	1.0	N.D.	2.2	N.D.	3.5	N.D.	1.5
BFR-207	N.D.	3.2	N.D.	1.4	N.D.	3.4	N.D.	5.9	N.D.	2.4
BFR-206	N.D.	8.1	N.D.	3.6	N.D.	8.7	N.D.	15	N.D.	6.1
BFR-209	32	23	43	8.0	63	20	110	32	37	13
MonoBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DiBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TriBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TetraBDE	6.4	1.1	2.5	2.1	1.2
PentaBDE	3.3	0.47	N.D.	N.D.	0.71
HexaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HeptaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
OctaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
NonaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DecaBDE	32	43	63	110	37
TotalPBDEs	42	45	66	110	39

定量下限未満は “N.D” と表示した。
参考資料(32) 測定結果 脂肪重量あたりのPBDEs濃度（ng/g-fat） ID-66～ID-70

No. (ID-0)	000066	000067	000068	000069	000070
試料名	臍帶83	臍帶85	臍帶94	臍帶95	臍帶96
試料量g	5.08	5.03	5.05	5.01	4.76
脂肪量mg/g	1.12	0.93	1.47	1.14	1.01
濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值
BFR-3	N.D.	1.4	N.D.	2.3	N.D.	1.8	N.D.	2.0	N.D.	2.1
BFR-7	N.D.	0.27	N.D.	0.44	N.D.	0.33	N.D.	0.37	N.D.	0.39
BFR-15	N.D.	0.16	N.D.	0.26	N.D.	0.20	N.D.	0.22	N.D.	0.23
BFR-17	N.D.	0.27	N.D.	0.44	N.D.	0.33	N.D.	0.36	N.D.	0.36
BFR-28	N.D.	0.28	N.D.	0.44	N.D.	0.33	N.D.	0.37	N.D.	0.37
BFR-49	N.D.	0.50	N.D.	0.78	N.D.	0.60	N.D.	0.65	N.D.	0.64
BFR-71	N.D.	0.37	N.D.	0.58	N.D.	0.44	N.D.	0.48	N.D.	0.48
BFR-47	1.0	0.30	0.94	0.48	0.69	0.36	1.0	0.39	1.5	0.39
BFR-66	N.D.	0.66	N.D.	1.0	N.D.	0.79	N.D.	0.86	N.D.	0.85
BFR-77	N.D.	0.43	N.D.	0.67	N.D.	0.51	N.D.	0.56	N.D.	0.55
BFR-100	N.D.	0.23	N.D.	0.39	N.D.	0.28	N.D.	0.31	N.D.	0.30
BFR-119	N.D.	0.41	N.D.	0.70	N.D.	0.50	N.D.	0.56	N.D.	0.55
BFR-99	N.D.	0.37	N.D.	0.62	N.D.	0.44	N.D.	0.50	N.D.	0.49
BFR-85	N.D.	0.55	N.D.	0.94	N.D.	0.67	N.D.	0.75	N.D.	0.74
BFR-126	N.D.	0.47	N.D.	0.80	N.D.	0.57	N.D.	0.64	N.D.	0.63
BFR-154	N.D.	0.54	N.D.	0.90	N.D.	0.65	N.D.	0.74	N.D.	0.73
BFR-153	N.D.	0.80	N.D.	1.3	N.D.	0.93	N.D.	1.1	N.D.	1.0
BFR-138	N.D.	1.1	N.D.	1.8	N.D.	1.3	N.D.	1.5	N.D.	1.4
BFR-156	N.D.	2.0	N.D.	3.2	N.D.	2.3	N.D.	2.7	N.D.	2.5
BFR-184	N.D.	0.35	N.D.	0.57	N.D.	0.43	N.D.	0.48	N.D.	0.45
BFR-183	N.D.	0.36	N.D.	0.59	N.D.	0.44	N.D.	0.49	N.D.	0.46
BFR-191	N.D.	0.46	N.D.	0.74	N.D.	0.56	N.D.	0.62	N.D.	0.59
BFR-197	N.D.	0.74	N.D.	1.2	N.D.	0.93	N.D.	1.1	N.D.	1.0
BFR-196	N.D.	0.83	N.D.	1.4	N.D.	1.0	N.D.	1.2	N.D.	1.1
BFR-207	N.D.	1.3	N.D.	2.2	N.D.	1.6	N.D.	1.9	N.D.	1.8
BFR-206	N.D.	3.2	N.D.	5.6	N.D.	4.1	N.D.	4.9	N.D.	4.5
BFR-209	26	6.5	78	12	75	8.3	30	11	60	8.7
MonoBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DiBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TriBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TetraBDE	1.0	0.94	0.69	1.0	1.5
PentaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HexaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HeptaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
OctaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
NonaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DecaBDE	26	78	75	30	60
Total PBDEs	27	79	76	31	62

定量下限未満は “N.D” と表示した。
参考資料(33) 測定結果 脂肪重量あたりのPBDEs濃度（ng/g-fat） ID-71～ID-75

No. (ID-0)	000071	000072	000073	000074	000075
试料名	臍带109	臍带121	臍带132	臍带156	臍带157
試料量g	5.03	5.06	5.02	5.05	5.06
脂肪量mg/g	0.88	0.87	0.94	0.67	0.63
濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值
BFR-3	N.D.	2.4	N.D.	5.9	N.D.	2.5	N.D.	6.9	N.D.	5.2
BFR-7	N.D.	0.43	N.D.	1.1	N.D.	0.48	N.D.	1.1	N.D.	1.0
BFR-15	N.D.	0.25	N.D.	0.63	N.D.	0.28	N.D.	0.66	N.D.	0.58
BFR-17	N.D.	0.45	N.D.	1.1	N.D.	0.50	N.D.	1.1	N.D.	0.99
BFR-28	N.D.	0.46	N.D.	1.1	N.D.	0.51	N.D.	1.2	N.D.	1.0
BFR-49	N.D.	0.84	N.D.	2.0	N.D.	0.99	N.D.	2.2	N.D.	2.0
BFR-71	N.D.	0.62	N.D.	1.5	N.D.	0.73	N.D.	1.6	N.D.	1.5
BFR-47	1.0	0.51	1.6	1.2	0.95	0.60	N.D.	1.3	N.D.	1.2
BFR-66	N.D.	1.1	N.D.	2.7	N.D.	1.3	N.D.	2.9	N.D.	2.6
BFR-77	N.D.	0.72	N.D.	1.8	N.D.	0.85	N.D.	1.9	N.D.	1.7
BFR-100	N.D.	0.39	N.D.	0.94	N.D.	0.44	N.D.	0.95	N.D.	0.86
BFR-119	N.D.	0.70	N.D.	1.7	N.D.	0.80	N.D.	1.7	N.D.	1.5
BFR-99	N.D.	0.63	N.D.	1.5	N.D.	0.71	N.D.	1.5	N.D.	1.4
BFR-85	N.D.	0.95	N.D.	2.3	N.D.	1.1	N.D.	2.3	N.D.	2.1
BFR-126	N.D.	0.80	N.D.	1.9	N.D.	0.92	N.D.	2.0	N.D.	1.8
BFR-154	N.D.	0.90	N.D.	2.1	N.D.	1.0	N.D.	2.1	N.D.	2.1
BFR-153	N.D.	1.3	N.D.	3.3	N.D.	1.6	N.D.	3.3	N.D.	3.3
BFR-138	N.D.	1.8	N.D.	4.5	N.D.	2.2	N.D.	4.4	N.D.	4.5
BFR-156	N.D.	3.3	N.D.	8.2	N.D.	4.0	N.D.	8.0	N.D.	8.2
BFR-184	N.D.	0.60	N.D.	1.4	N.D.	0.70	N.D.	1.3	N.D.	1.3
BFR-183	N.D.	0.62	N.D.	1.5	N.D.	0.72	N.D.	1.4	N.D.	1.4
BFR-191	N.D.	0.79	N.D.	1.9	N.D.	0.91	N.D.	1.7	N.D.	1.7
BFR-197	N.D.	1.2	N.D.	3.3	N.D.	1.7	N.D.	3.2	N.D.	3.3
BFR-196	N.D.	1.4	N.D.	3.7	N.D.	1.9	N.D.	3.5	N.D.	3.7
BFR-207	N.D.	2.1	N.D.	6.8	N.D.	3.1	N.D.	5.9	N.D.	6.3
BFR-206	N.D.	5.3	N.D.	17	N.D.	8.0	N.D.	15	N.D.	16
BFR-209	49	11	N.D.	54	29	20	62	44	120	39
MonoBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DiBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TriBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TetraBDE	1.0	1.6	0.95	N.D.	N.D.
PentaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HexaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HeptaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
OctaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
NonaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DecaBDE	49	N.D.	29	62	120
TotalPBDEs	50	1.6	30	62	120

定量下限未満は “N.D” と表示した。
参考資料(34) 測定結果 脂肪重量あたりのPBDEs濃度（ng/g-fat） ID-76～ID-80

No. (ID-0)	000076	000077	000078	000079	000080
试料名	臍带158	臍带159	臍带161	臍带163	臍带164
試料量g	5.07	5.07	5.04	5.07	5.06
脂肪量mg/g	0.89	0.85	1.23	0.85	0.91
濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值
BFR-3	N.D.	2.8	N.D.	3.3	N.D.	2.1	N.D.	2.5	N.D.	2.8
BFR-7	N.D.	0.55	N.D.	0.53	N.D.	0.34	N.D.	0.46	N.D.	0.48
BFR-15	N.D.	0.32	N.D.	0.31	N.D.	0.20	N.D.	0.27	N.D.	0.28
BFR-17	N.D.	0.52	N.D.	0.53	N.D.	0.32	N.D.	0.47	N.D.	0.45
BFR-28	N.D.	0.53	N.D.	0.54	N.D.	0.32	N.D.	0.48	N.D.	0.46
BFR-49	N.D.	0.99	N.D.	0.99	N.D.	0.58	N.D.	0.83	N.D.	0.84
BFR-71	N.D.	0.74	N.D.	0.74	N.D.	0.43	N.D.	0.62	N.D.	0.62
BFR-47	2.0	0.61	0.83	0.61	1.0	0.35	1.8	0.51	1.6	0.51
BFR-66	N.D.	1.3	N.D.	1.3	N.D.	0.77	N.D.	1.1	N.D.	1.1
BFR-77	N.D.	0.86	N.D.	0.85	N.D.	0.50	N.D.	0.72	N.D.	0.72
BFR-100	N.D.	0.44	N.D.	0.46	N.D.	0.25	N.D.	0.40	N.D.	0.38
BFR-119	N.D.	0.80	N.D.	0.83	N.D.	0.45	N.D.	0.72	N.D.	0.68
BFR-99	1.5	0.71	N.D.	0.74	N.D.	0.40	0.68	0.64	N.D.	0.60
BFR-85	N.D.	1.1	N.D.	1.1	N.D.	0.61	N.D.	0.97	N.D.	0.92
BFR-126	N.D.	0.92	N.D.	0.95	N.D.	0.52	N.D.	0.82	N.D.	0.78
BFR-154	N.D.	1.1	N.D.	1.1	N.D.	0.60	N.D.	0.92	N.D.	0.93
BFR-153	N.D.	1.7	N.D.	1.8	N.D.	0.92	N.D.	1.4	N.D.	1.4
BFR-138	N.D.	2.3	N.D.	2.4	N.D.	1.2	N.D.	1.9	N.D.	1.9
BFR-156	N.D.	4.1	N.D.	4.4	N.D.	2.3	N.D.	3.5	N.D.	3.5
BFR-184	N.D.	0.79	N.D.	0.73	N.D.	0.40	N.D.	0.61	N.D.	0.61
BFR-183	N.D.	0.81	N.D.	0.75	N.D.	0.41	N.D.	0.62	N.D.	0.62
BFR-191	N.D.	1.0	N.D.	0.95	N.D.	0.52	N.D.	0.79	N.D.	0.79
BFR-197	N.D.	1.6	N.D.	1.6	N.D.	0.87	N.D.	1.3	N.D.	1.4
BFR-196	N.D.	1.8	N.D.	1.8	N.D.	0.97	N.D.	1.5	N.D.	1.6
BFR-207	N.D.	3.3	N.D.	2.8	N.D.	1.5	N.D.	2.4	N.D.	2.3
BFR-206	N.D.	8.3	N.D.	7.1	N.D.	3.8	N.D.	6.1	N.D.	5.9
BFR-209	58	20	120	14	38	8.3	26	15	61	14
MonoBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DiBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TriBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TetraBDE	2.0	0.83	1.0	1.8	1.6
PentaBDE	1.5	N.D.	N.D.	0.68	N.D.
HexaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HeptaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
OctaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
NonaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DecaBDE	58	120	38	26	61
TotalPBDEs	62	120	39	28	63

定量下限未満は“N.D”と表示した。
参考資料(35) 測定結果 脂肪重量あたりのPBDEs濃度（ng/g-fat） ID-81～ID-85

No. (ID-0)	000081	000082	000083	000084	000085
試料名	臍帶166	臍帶168	臍帶170	臍帶177	臍帶178
試料量g	5.05	5.05	5.00	5.02	5.04
脂肪量mg/g	1.47	0.59	1.50	1.14	0.91
濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值
BFR-3	N.D.	1.7	N.D.	4.1	N.D.	1.8	N.D.	1.8	N.D.	2.1
BFR-7	N.D.	0.31	N.D.	0.70	N.D.	0.30	N.D.	0.33	N.D.	0.34
BFR-15	N.D.	0.18	N.D.	0.41	N.D.	0.18	N.D.	0.19	N.D.	0.20
BFR-17	N.D.	0.33	N.D.	0.66	N.D.	0.31	N.D.	0.33	N.D.	0.32
BFR-28	N.D.	0.34	N.D.	0.67	N.D.	0.31	N.D.	0.33	N.D.	0.32
BFR-49	N.D.	0.62	N.D.	1.2	N.D.	0.56	N.D.	0.63	N.D.	0.60
BFR-71	N.D.	0.46	N.D.	0.88	N.D.	0.42	N.D.	0.47	N.D.	0.45
BFR-47	1.1	0.38	2.0	0.72	0.84	0.34	0.69	0.38	1.2	0.37
BFR-66	N.D.	0.82	N.D.	1.6	N.D.	0.75	N.D.	0.83	N.D.	0.80
BFR-77	N.D.	0.53	N.D.	1.0	N.D.	0.49	N.D.	0.54	N.D.	0.52
BFR-100	N.D.	0.26	N.D.	0.55	N.D.	0.26	N.D.	0.28	N.D.	0.27
BFR-119	N.D.	0.47	N.D.	0.99	N.D.	0.47	N.D.	0.50	N.D.	0.48
BFR-99	N.D.	0.42	0.89	0.88	N.D.	0.42	N.D.	0.45	N.D.	0.43
BFR-85	N.D.	0.64	N.D.	1.3	N.D.	0.64	N.D.	0.68	N.D.	0.65
BFR-126	N.D.	0.54	N.D.	1.1	N.D.	0.54	N.D.	0.58	N.D.	0.55
BFR-154	N.D.	0.64	N.D.	1.3	N.D.	0.64	N.D.	0.64	N.D.	0.63
BFR-153	N.D.	1.0	N.D.	1.9	N.D.	0.95	N.D.	0.97	N.D.	0.96
BFR-138	N.D.	1.4	N.D.	2.5	N.D.	1.3	N.D.	1.3	N.D.	1.3
BFR-156	N.D.	2.4	N.D.	4.6	N.D.	2.3	N.D.	2.4	N.D.	2.4
BFR-184	N.D.	0.44	N.D.	0.82	N.D.	0.44	N.D.	0.45	N.D.	0.42
BFR-183	N.D.	0.45	N.D.	0.84	N.D.	0.46	N.D.	0.46	N.D.	0.43
BFR-191	N.D.	0.57	N.D.	1.1	N.D.	0.58	N.D.	0.59	N.D.	0.55
BFR-197	N.D.	1.0	N.D.	1.9	N.D.	0.98	N.D.	0.96	N.D.	0.91
BFR-196	N.D.	1.1	N.D.	2.1	N.D.	1.1	N.D.	1.1	N.D.	1.0
BFR-207	N.D.	1.7	N.D.	3.5	N.D.	1.8	N.D.	1.7	N.D.	1.6
BFR-206	N.D.	4.3	N.D.	8.8	N.D.	4.6	N.D.	4.2	N.D.	3.9
BFR-209	32	10	130	20	38	12	36	9.2	46	9.1
MonoBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DiBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TriBDE	N.D.	N.D.	N.D.	N.D.	N.D.
TetraBDE	1.1	2.0	0.84	0.69	1.2
PentaBDE	N.D.	0.89	N.D.	N.D.	N.D.
HexaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
HeptaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
OctaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
NonaBDE	N.D.	N.D.	N.D.	N.D.	N.D.
DecaBDE	32	130	38	36	46
TotalPBDEs	33	130	39	37	47

定量下限未満は “N.D” と表示した。
参考資料(36) 測定結果 脂肪重量あたりのPBDEs濃度（ng/g-fat） ID-86

No. (ID-0)	000086
試料名	臍帶180
試料量g	5.04
脂肪量mg/g	0.83
濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值	濃度ng/g-fat	定量下限值
BFR-3	N.D.	3.4
BFR-7	N.D.	0.60
BFR-15	N.D.	0.35
BFR-17	N.D.	0.58
BFR-28	N.D.	0.59
BFR-49	N.D.	1.1
BFR-71	N.D.	0.79
BFR-47	0.75	0.65
BFR-66	N.D.	1.4
BFR-77	N.D.	0.91
BFR-100	N.D.	0.48
BFR-119	N.D.	0.87
BFR-99	N.D.	0.78
BFR-85	N.D.	1.2
BFR-126	N.D.	1.0
BFR-154	N.D.	1.2
BFR-153	N.D.	1.9
BFR-138	N.D.	2.6
BFR-156	N.D.	4.7
BFR-184	N.D.	0.80
BFR-183	N.D.	0.82
BFR-191	N.D.	1.0
BFR-197	N.D.	1.8
BFR-196	N.D.	2.0
BFR-207	N.D.	3.4
BFR-206	N.D.	8.6
BFR-209	52	23
MonoBDE	N.D.
DiBDE	N.D.
TriBDE	N.D.
TetraBDE	0.75
PentaBDE	N.D.
HexaBDE	N.D.
HeptaBDE	N.D.
OctaBDE	N.D.
NonaBDE	N.D.
DecaBDE	52
TotalPBDEs	53

定量下限未満は“N.D”と表示した。
# Environmental Contaminants and Children's Health

Sustainable Health Science for Future Generations

MORI, Chisato and TODAKA, Emiko

Center for Preventive Medical Science,

Chiba University, Japan

MARUZEN PLANET Co., Ltd.
C-0904-59

本研究関連文献（2）

# Environmental Contaminants and Children’s Health

Sustainable Health Science for Future Generations

By MORI, Chisato and TODAKA, Emiko

First English edition: 2011

Second impression: 2011

The original Japanese edition published by Gijutsu-Hyohron Co. Ltd., TOKYO. Copyright © 2008, 2011 MORI, Chisato and TODAKA, Emiko

All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage retrieval system, without permission.

The English translation published by Maruzen Planet Co., Ltd., TOKYO.

PRINTED IN JAPAN
# 1-1. Everyone Is Affected

It may be a surprise to learn that all modern-day people are contaminated even before they are born. A study of umbilical cords of newborns in Japan, however, detected many environmental contaminants (Fig. 1-1).

For example, dioxins are emitted into the environment mainly as impurities created when waste is incinerated. PCBs are industrial chemicals whose manufacture and import have been banned for more than 35 years in Japan. Similarly, the use, manufacture, and import of DDT, a pesticide, are prohibited. DDE is a metabolite of DDT. PBDE (polybrominated diphenyl ether) is a flame retardant used to prevent fire in electrical appliances, carpets, and other items.

Why are even unborn babies contaminated? It comes down to the fact that many contaminants accumulate inside the bodies of fish and animals which are eventually consumed by humans and accumulate in the body. Contaminants in the mother's body are then passed on to her baby through the umbilical cord.

After birth, the baby’s umbilical cord is usually removed and disposed of as medical waste. But the umbilical cord offers important clues about contaminants to which unborn children are exposed during pregnancy.

Available analysis and measuring technologies, as well as budget constraints, limit the number of contaminants that can be measured. One can easily imagine that many more contaminants than those reported here are transferred from the mother to the fetus.

Fig. 1-1 Example of substances detected from umbilical cords/detection rates

When umbilical cords from newborns in Japan are tested, high percentages of various accumulative contaminants can be detected.
### 1 -2. Chemicals: Benefits and Risks

Humankind’s environment has changed radically over the past century, especially in developed countries. In this modern era, we live surrounded by thousands of man-made chemicals that did not exist even a hundred years ago. Such chemicals were created to make our lives more convenient and comfortable, to improve energy efficiency, or to make our lives healthier. Everyone living in modern times has benefited from chemicals.

Substance	Average Concentration*	Detection Rate (%)
Dioxins	0.031	100
PCBs	0.075	100
DDT + DDE	0.138	100
Hexachlorobenzene (HCB)	0.023	100
$ \beta $ -Hexachlorocyclohexane (HCH)	0.074	100
Endosulfan	0.035	90
trans-Nonachlor	0.017	100
cis-Nonachlor	0.003	100
Oxychlordane	0.009	100
Polybrominated diphenyl ether (PBDE)	0.009	100

Table 1-2 Concentration and detection rates for

Environmental contaminants detected from umbilical cords

Detected from the umbilical cords of a total of 1,000 newborns.

The umbilical cord is part of the fetus's body and is a valuable source of information on contamination during the fetal period.

All substances listed in the table are accumulative, and they tend to be detected at high percentages as they are not easily excreted once they have entered the body.

*Concentration: The unit for concentration is pg-TEQ/g wet for dioxin, and ng/g wet for the other substances. "Pg" stands for picogram: one pg equals one trillionth of a gram. TEQ stands for "toxicity equivalence quantity." This unit evaluates the toxicity of dioxin and its isomers with the most toxic form of dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin, having a value of 1. "Ng" stands for nanogram: 1 ng equals one billionth of a gram. "Wet" stands for wet weight, indicating that analysis was carried out without drying the umbilical cord.
### 4 -3. Other Contaminants

## Flame retardants

Even though production of PCBs has been banned for over 30 years in Japan, they are still present in the human body. Because PCBs have such a serious impact on humans, continued caution is necessary.

Fig. 4-II Flame retardants in the home

Flame retardants are used in various items to prevent fire.
Many other substances also pollute the environment. One of these is brominated flame retardant, which is still produced and used in ever increasing quantities despite concerns about its effects on human health.

Flame retardants are used to prevent fire in electrical appliances, building materials, and carpets (Fig. 4-11). There are many types of flame retardant, but brominated flame retardant, which is high-performance and cost-effective, is in wide use.

In western countries, it has been noted that flame retardant levels detectable in breast milk are on the rise. Flame retardant has also been detected in umbilical cords and breast milk in Japan.

Table 4-12 shows levels of a brominated flame retardant, PBDE (polybrominated diphenyl ether), in breast milk fat, maternal blood, umbilical cord blood, and umbilical cord tissues from Japanese women. Although levels were much lower compared to PCBs, flame retardant was detected in all the subjects.

## PBDE and its effects on boys

In the past few years, researchers in Denmark and Finland reported a relationship between PBDE levels in breast milk and cryptorchidism, a birth defect of the male

Specimen type (No. of specimens)	Polybrominated diphenyl ether (PBDE) Average (MIN-MAX) <pg/g wet>*	PCBs Average (MIN-MAX) <pg/g wet>*	Dioxins Average (MIN-MAX) <pg-TEQ/g wet>*
Breast milk (8)	143 (16-667)	3868 (1536-7223)	—
Maternal blood (16)	25.4 (11.3-94.7)	564 (133-1159)	—
Umbilical cord blood (8)	4.8 (0.57-15.4)	118 (40-207)	—
Umbilical cord (16)	3.2 (0.47-11.1)	56.3 (13-117)	0.031 (0.012-0.053) [Number of specimens: 20]

$ ^{*} $ See Section 1-2 for information on units used.

Table 4-12 Levels of brominated flame retardants (PBDE), PCBs, and dioxins in breast milk (fat), maternal blood, umbilical cord blood, and umbilical cord tissue from Japanese women

Dioxin levels were measured in umbilical cord tissue only.
reproductive organs. In cryptorchidism, the testes, which should be settled in the scrotum by the time of birth, have not descended and remain in the inguinal or abdominal cavity (Fig. 4-13).

Though this defect occurs in approximately 3% of boys at birth, the occurrence rate drops to 1–2% by three months of age, as sometimes the testes descend slowly by themselves after birth. If the testes remain undescended, the risk of cancer is very high, so they are either fixed inside the scrotum by surgery or removed completely.

In Denmark and Finland, when PBDE levels in breast milk from mothers of 95 boys with cryptorchidism and 185 mothers of healthy boys were analyzed, the former group had significantly higher PBDE levels.

A high level of PBDE in breast milk suggests that the mothers could have been exposed to the substance during or before pregnancy. Likely causes of cryptorchidism are insufficiency of male hormone produced in the testes of the male fetus; dysfunction due to an abnormality of the hormonal receptors, even when normal levels of male hormone are present; or an excess of female hormone received from the mother.

In animal experiments, it was reported that a high level of PBDE suppresses the function of the male hormone. The research group speculates that high PBDE levels in mothers hampers testicular descent, due to its anti-androgenic effect in male fetuses.

Fig. 4-13 Cryptorchidism

Level I: upper scrotum; Level II: lower inguinal canal; Level III: upper inguinal canal; Level IV: abdominal cavity

The higher the location of the testis, the severer the condition. Males with cryptorchidism are 20–50 times more likely to develop testicular cancer compared to normal males.

Adapted from Shin rinsho zufu (New Clinical Illustrations), Igaku Kyoiku Shuppansha Co., Ltd.
Study on Relationship between Infant Allergic Disease and Exposure to Environmental Pollutants Including Brominated Flame Retardants (BFRs) during Fetal and Infant Period in Japan

Principal Investigator: Chisato MORI

Institution: Chiba University, Department of Bioenvironmental Medicine,

Graduate School of Medicine, Chiba University,

1-8-1 Inonaha, Chiba, 260-8670 Japan

Tel:+81-43-226-2017, Fax:+81-43-226-2018,

E-mail:cmori@faculty.chiba-u.jp

## [Abstract]

Key Words: Brominated flame retardants (BFRs), Fetal and neonatal exposure, Allergic disease, High-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS), Questionnaire survey

Flame retardants are used to prevent combustion in consumer products such as electronics, construction materials, and textiles. Although there are several groups of flame retardants, brominated flame retardants (BFRs) are the most frequently used group in the world currently. BFRs include polybrominated diphenyl ethers (PBDEs) and tetrabromobisphenol A (TBBPA).

There are many reports concerning the concentrations of PBDEs in human tissues and fluids, such as maternal blood, maternal breast milk, cord blood and placenta. These studies have shown that human fetuses are exposed to PBDEs. The routes of human exposure to PBDEs are mainly thought to be food consumption and house dust. There are reports to doubt the correlation between children's allergies and exposure to BFRs, but it has not been elucidated enough. Therefore, it is important to investigate the relationship between infant allergic disease and exposure to BFRs during fetal and infant period.

The purpose of the present study was to evaluate exposure level to BFRs in mothers and fetuses in Japan, and to find the correlation between the exposure levels and diagnose of children’s allergies. First, PBDEs were measured in umbilical cord tissue samples obtained from 86 newborn babies at a maternity clinic in Chiba, Japan. Twenty-seven PBDE congeners were analyzed and the average of the total of these 27 PBDEs was 70.9 pg/g-wet. Congeners detected were, BDE-209, BDE-47, BDE-99, BDE-100 and BDE-153, and among them, BDE-209 was the most dominant compound.

Among the 86 children whose PBDEs were analyzed, 80 children were followed until at the age of 7 months because their data were determined and questionnaires were completed. The relationship between their symptoms of allergies and the concentration level of PBDEs in cord
tissue were investigated. Twenty-seven children were diagnosed as atopic dermatitis, and 53 children were diagnosed as non-allergic dermatitis. When the concentration level of PBDEs and diagnoses of atopic dermatitis were investigated, there was a correlation between total PBDEs level and some congeners/isomers of PBDEs and atopic dermatitis. The correlation was stronger when the concentration level was higher. Also, it was indicated that the onset and aggravation of atopic dermatitis by fetal exposure to PBDEs were inflammatory effect, not allergic. From the current study, it became clear that more detail study would be necessary to elucidate the relationship between children's allergies and chemical exposure, especially exposure from maternal breast milk and genetic background, in addition to the data of fetal exposure.
## C-0904 微量化学物質の胎児・新生児期曝露と乳幼児のアレルギー疾患の関連性に関する研究

臍帯中の臭素化難燃剤 (臭素化ジフェニルエーテル : PBDE) 濃度と出産児から乳幼児期までのアレルギー症状発症に関する研究

研究代表者：森千里(千葉大学)

【目的】臍帯中の臭素化難燃剤（臭素化ジフェニルエーテル：PBDE）を測定し、出生時曝露レベルと乳幼児期まで臨床現場あるいはアンケート調査で追跡が可能な被験者について、継続的にアレルギー症状について調査し、PBDEの曝露量とアレルギー疾患との関連性を統計的に解析する。

アンケート・診察

7か月、(2歳)

【結果】

1)PBDEsが全ての臍帯試料から検出された。

2)アトピ一性皮膚炎とTotalPBDEsおよび一部の同族体/異性体において有意差が認められたことから、PBDEsの曝露濃度が高い場合、アトピ一性皮膚炎の発症に関連している可能性が示された。