表(2)-7. 色素沈着群と非色素沈着群の臨床像

Characteristics	All subjects	Born within the first 5 years after exposure
Black baby	non-Black baby	p valuesc	Black baby	non-Black baby	p valuesc
Mother
Number	9	61	7	17
Maternal age at exposure (years)	20.3 ± 6.1 (7-27)a	15.4 ± 8.4 (0-29)a	0.1052	21.3 ± 3.4 (16-26)a	24.1 ± 3.3 (20-29)a	0.0784
prenatal	0 (0)	3 (4.9)	0 (0)	0 (0)
0-10	1 (11.1)	17 (27.9)	0 (0)	0 (0)
11-20	2 (22.2)	21 (34.4)	2 (28.6)	17 (100)
21-35	6 (66.7)	20 (32.8)	5 (71.4)	0 (0)
Age at blood sampling (years)	57.4 ± 5.9 (45-64)a	52.5 ± 9.1 (32-68)a	0.1079	58.7 ± 4.1 (53-64)a	62.2 ± 3.4 (58-68)a	0.0908
Date of blood sampling (years)	2006 (2002-2006)b	2006 (2002-2008)b	0.0582	2006 (2002-2006)b	2006 (2002-2008)b	0.2455
Number of birth	1.8 ± 0.7 (1-3)a	1.9 ± 0.8 (1-5)a	0.9153	1.7 ± 0.8 (1-3)a	1.8 ± 0.9 (1-4)a	0.8636
1	3 (33.3)	21 (34.4)	3 (42.85)	7 (41.2)
2	5 (55.6)	31 (50.8)	3 (42.85)	7 (41.2)
3	1 (11.1)	6 (9.8)	1 (14.3)	2 (11.8)
4	0 (0)	2 (3.3)	0 (0)	1 (5.8)
5	0 (0)	1 (1.7)	0 (0)	0 (0)
Breast fed their children	4 (44.4)	33 (54.1)	0.7257	4 (57.1)	10 (58.8)	1.0000
Duration of breast feeding (years)	0.5 ± 0.5 (0-1)a	0.7 ± 1.2 (0-6)a	0.6268	0.5 ± 0.5 (0-1)a	1.0 ± 1.7 (0-6)a	1.0000
Frequency of seafood consumption	0.4381	e	0.5747
every day	3 (33.3)	8 (13.1)	3 (42.85)	4 (23.5)
3-4 times/week	3 (33.3)	25 (41.0)	3 (42.85)	8 (47.1)
1-2 times/week	3 (33.3)	25 (41.0)	1 (14.3)	5 (29.4)
1-2 times/month	0 (0)	3 (4.9)	0 (0)	0 (0)
almost never	0 (0)	0 (0)	0 (0)	0 (0)
Age at delivery (years)	23.9 ± 4.1 (18-32)a	27.1 ± 4.0 (19-36)a	0.0258	21.9 ± 2.7 (18-26)a	26.2 ± 2.7 (22-31)a	0.0020
Smoking status during pregnancy	0.4308	d	0.2917
Non-smoking	8 (88.9)	58 (95.1)c	6 (85.7)	17 (100)
Smoking	1 (11.1)	3 (4.9)c	1 (14.3)	0 (0)
Infant
Number	10	107	8	21
Date of birth (year)	1969.5 (1968-1988)b	1982 (1968-2006)b	0.0002	1968.5 (1968-1972)b	1970 (1968-1972)b	0.1323
1968-1972	8 (80)	21 (19.6)	8 (100)	21 (100)
1973-1977	1 (10)	18 (16.8)	0 (0)	0 (0)
1978-1987	0 (0)	32 (29.9)	0 (0)	0 (0)
1988-2006	1 (10)	36 (33.7)	0 (0)	0 (0)
Gestational age at birth (weeks)	39.2 ± 0.4 (39-40)a	39.1 ± 1.1 (32-42)a	0.7442	39.2 ± 0.4 (39-40)a	38.5 ± 1.8 (32-40)a	0.5577
Birth weight (g)	2994 ± 457 (2140-3800)a	3056 ± 369 (1950-3980)a	0.5103	3036 ± 353 (2750-3800)a	3007 ± 456 (2000-3900)a	0.9805
Infant gender	0.1006	0.0667
Male	3 (30)	63 (58.9)	3 (37.5)	17 (81.0)c
Female	7 (70)	44 (41.1)	5 (62.5)	4 (19.0)c
Number of blood sampling	7	29	4	7
(number of male/female)	male:female=2:5	male:female=21:8	0.0733	male:female=1:3	male:female=5:2	0.2424
Age at blood sampling (years)	36.1 ± 7.1 (21-41)a	30.8 ± 10.1 (11-45)a	0.0884	38.2 ± 3.7 (34-41)a	37.9 ± 2.7 (33-41)a	0.3885
Date of blood sampling (years)	2009 (2007-2010)b	2009 (2002-2010)b	0.9669	2009 (2007-2010)b	2009 (2006-2010)b	0.7690
Formula fed in infancy	4 (57.1)	12 (41.4)	0.6750	4 (100)	7 (100)	1.0000

Data are shown Number (%). $ {}^{a} $ Mean ± SD (range), $ {}^{b} $ Median (range), $ {}^{c} $ Mann-Whitney U test, $ {}^{d} $ Fisher's exact test, $ {}^{e} $ chi-square test.

色素沈着群と非色素沈着群における母体の出産時推定血中ダイオキシン類濃度を表(2)-8に示す。母体出産時のtotalPCDD、totalPCDF、totalnon-orthoPCBsおよびtotalTEQ平均濃度は、色素沈着群で736.5、1923.9、57.6および2719.7TEQ pg/glipidで、非色素沈着群の値（243.0、460.7、31.8および761.7TEQ pg/glipid）と比して有意に高値を示した。また、21異性体のなかで測定が可能であった13異性体すべてにおいて色素沈着群の値は非色素沈着群の値に比して有意