## Medical treatment technology, Diagnostic technology

## Life Sciences

## Patient Specific Blood Vessel Model for Endovascular Surgery Training

Keyword: Fruit of 20-Year Medicine / Engineering Cooperative Research, Trend Analysis, and Business Creation Support by JST and TLO

## Organizations Involved

O Toshio Fukuda, Professor, School of Engineering, Nagoya University

O Makoto Negoro, Professor, School of Medicine, Fujita Health University

O Seiichi Ikeda, President, FAIN-Biomedical Inc.

## [Summary of the technology transfer]

Technological Impact

Prof. Fukuda

## 【Abstract】

## Market Impact

* Physical properties of blood vessel tissue, such as elastic modulus and friction coefficient, are also reproduced on this model (error: $ < 10\% $ ). CT compatible.

* Wall stress during surgical simulation is measured by advanced photoelastic analysis. It enables quantitative evaluation of skill and product performance

Nagoya University developed a technology to precisely reproduce patient-specific blood vessel structure as 3-dimensional transparent silicone model, and succeeded in developing "a patient-specific endovascular surgery simulator". Closely watching the trend of surgical skill licensing system and applying for patents under CTLO support, this group succeeded in starting a business with "whole body endovascular simulator (EVE) for surgical training" in 2005.

* Surgical simulator is attracting interest as an alternative to animal test with the preparation of surgical skill licensing system in neurosurgery field and the increasing regulation of animal testing for product evaluation. Rapid market growth is expected in this field.

* Patient specific blood vessel structure is reproduced as a transparent silicone model by advanced rapid prototyping technology at high precision (13 mm) based on CT/MRI information. This technology allows to reproduce entire circulatory system treated in endovascular surgery (min. diameter: 0.8 mm).

## ●Social Impact

* Animal test prevails for surgical simulation now, and many life become victim of the activity every year. This technology saves the life. Needless to say, this technology increases the reliability and safety of medical treatment and consequently saves patient's life. This patient-specific surgical simulator is also applicable to pre-surgical trial and informed consent (fabrication time: <24 hours).

Prof.

Negoro

Ikeda

## Project Background

A chance for a practical cooperative research was given by JST project (business creation support) as a result of 20-year medicine / engineering cooperative research.

## Funding History

This project is supported by JST patent support and the following fundings.

1. MEXT (2002-2004)

2. NEDO (2004-2005)

3. JSPS (2006-2008)

4. SMRJ (2006)

## I ntellectual property protection

Patented: Domestic: 2, PCT: 2

“3 Dimensional Model, PCT/JP03/05590” et al.

Patent Pending: Domestic:12, PCT: 1

“Surgical Simulator, JP2005-315832” et al.

Trade Mark and Utility Model: Not applied

## Patient Specific Blood Vessel Model

### Blood vessel is reproduced as a simulator (Left). Photoelastic effect visualizes its wall stress (Right)

## EVE

Started a business with a whole body endovascular simulator "EVE" (Unuversal Design Award in Good Design Award 2006).

## Turning point in the Project

OEstablish a de facto standard in simulator business as an alternative to current animal test, by cooperating with doctors and medical companies.

OBuild doctor's confidence in its ability as a device for surgical skill licensing system by participating medical congresses and training seminars.

For more information, contact: Seiichi Ikeda, Fukuda Laboratory at Nagoya University, +81-52-788-6013, ikeda@robo.mein.nagoya-u.ac.jp