## Medical treatment technology, Diagnostic technology

## Life Sciences

## Fourier radar microscope - observation interior of living body by light -

Keyword: Optical coherence tomography, Three-dimensional fundus measurement with highest resolution

## Organizations Involved

Toyohiko Yatagai, Affiliate professor, Institute of Applied Physics, University of Tsukuba. (Optics research and education center, Utsunomiya University. Professor)

☐ Takashi Yokokura, President, Topcon Corporation.

T.Yokokura

## 【Abstract】

Computational Optics Group in the University of Tsukuba succeeded in the development of the Fourier-domain optical coherence tomography (OCT) system supported by the program of Development of Systems and Technology for Advanced Measurement and Analysis of the Japan Science and Technology Agency (JST). This technology was used for the fundus camera equipment produced by Topcon Corp., and the three-dimensional optical coherence tomography for fundus imaging system with the highest performance of the world was produced commercially.

## [Summary of the technology transfer]

## Technological Impact

●OCT equipment with the high speed and high spatial resolution of the record in the world which enables a measurement of the living tissue.

●Observation of an eyeball, and evaluation of skin structure.

●When this microscope is built into an endoscope, observation of the surface tissue of the stomach or lungs, or evaluation, diagnosis, etc. of a cancerous tissue is possible.

●Contribution to a medical advancement hen this microscope is built into an endoscope.

●Market Impact

By simultaneous acquisition of a color fundus image and an OCT image, specification of a observing part is possible. Clinical meaning is large, because it is independent of the measurement person's level of skill, and the reproducibility of progress observation increased. As a doctor, by oneself, was able to take out each tomogram from a three-dimensional image in arbitrary positions, it became clear that a detailed pathological change exists in the part of alien position.

●Since the tomographic picture of a wide range part is acquirable by a high speed, high sensitivity, and high resolving, the visualization for retinal layers is possible. The social contribution is large in which a possibility that a new diagnostic indicator could be built by the three-dimensional analysis.

●As the three-dimensional display was achieved, the informed consent to the patient becomes more persuasive, and a re-visit to the hospital is urged.

* OCT market size anticipation : [ in 2007] about 1,450 sets, : [ in 2008] about 1,600 sets

## Project Background

Based on the research presentation in a society, technical discussion was performed and development by technology transfer was performed.

## Funding History

●H17-18 Grants-in-aid-for-scientific-research young scientists (B) (Japan Society for the Promotion of Science)

●H16-19 Development of Systems and Technology for Advanced Measurement and Analysis (JST) etc.

## I ntellectual property protection

Patent application : The country 12,

Foreign countries 4

「Calibration method of component

apparatus of optical coherence tomography

(2005-291789)Jetc.

## 3 D OCT-1000

Integration of optical coherence tomography and fundus camera. High speed scanning of 0.05 sec./B-scan and 3.5 sec./3D-scan (Fifty times higher than conventional instrument).

Example of OCT image (macular hole)

## Turning point in the Project

A high level technical development is performed at the university, and the seeds of the university are advertised clearly.

☐ Suitable funding of suitable time.