Product review (2 stars): Should work, not as pictured though.
I have to agree with the other reviewers - this is not the filter pictured.  It is indeed a genuine Honeywell "type E" filter but does not have the blue antimicrobial layer and does not look like the filter than came with my large Honeywell humidifier despite it the documentation saying to purchase this filter.  It does say "antimicrobial" on the package so perhaps they incorporated it into the filter somehow?  It still doesn't have the blue pre-filter though and doesn't match the picture here.  Looks like it will work as a wicking filter but not a direct replacement of the original.