NICE STUDY HERE ... READ (NOT A SCAM)
A double-blind placebo- controlled study was conducted at Osaka City University to evaluate the effmts of oral administration of supplements containing rice ceramides in 33 patients with a habitual tendency toward dry, rough skin. The 33 patients were comprised of 6 men and 27 women, and the study was performed in keeping with the tenets of the Helsinki Accord, with written Informed Consent forms. This study was performed as a double-blind trial involving 6-week oral administration of “functional supplements” containing rice-derived Ceramides or a placebo.<br /><br />The test supplement was given in the form of soft capsules provided by Oryza Oil & Fat Chemical Co., Ltd., with a daily consumption of rice-derived Oryza Ceramide, 40 mg/day, containing rice-derived sphingolipids of 1.2mg/day. Placebo capsules were administered that were identical in appearanceand smell, but containing 0 mg/day of rice-derived Oryza Cerarnide and 0 mg/day of rice-derived sphingolipids. After the 6-week trial period, no subjects had dropped out and no adverse events were reported. Other evidence of the safety of ingested Ceramides is also presented in this study:<br /><br />Experiments have shown that after oral administration plant-based ceramides are absorbed unchanged in the small intestine or are broken down into sphingosine and fatty acids for absorption and are then reconfigured as ceramides. The substance is then transported by the capillaries into the horny layer and the keratin intercellular spaces. The supplements containing rice ceramides as used in this study, in contrast to the ceramide substances distributed in animal brains, provide superior supplementation that can be exnected to be both safe and effective for oral administration.<br /><br />Confirming this assessment is Lati, who as early as 1995 wrote about the use of ceramides in functional foods:<br /><br />Ceramide has been highly appraised in the field of functional foods because of its hydration characteristics and vectorization of vitamins (vitamin C and E). Presently phyto-ceramides by INOCOSM [Laboratories] are used as ingredients for various functional and cosmeceutical foods. Because of its hydration characteristics, ceramide is most extensively used in this field, and it is generally used together with vitamins. Ceramide has shown numerous benefits as a food additive because of its very unique characteristics, and it is effective not only for the tissues but also for the stabilization of foods in some cases. If a certain amount of phyto-ceramide is ingested every day, the following benefits could be attained:<br /><br />- Because ceramide suppresses free radicals, ceramide can enhance the protection<br />of tissues from external harmful effects (pollution, sunshine,and stress).<br />- Ceramide moisturizes the skin by its hydration capability.<br />- Ceramide achieves wrinkle prevention by its elastase suppression and collagen protection.<br /><br />. . . On the other hand, if ceramide is added to drinks for the benefit of the tissues, ceramide can also stabilize hydrophobic flavoring ingredients and hydrophobic molecules (vitamins) by vectorization. These conclusions are based in part on Lati’s 1995 study which concludes that phyto- ceramides taken orally improve the hydration of the skin. The phyto-ceramides were given at an amount of 20 mg/day for a month. No adverse effects or events were reported.<br /><br /> http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-rpt0240-05-Udell-vol175.pdf
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