Gensoumaden Saiyuuki
English name: Saiyuki
Genres: Action, Adventure, Comedy, Drama, Supernatural
Type: TV, Episodes: 50
Aired: Apr 4, 2000 to Mar 27, 2001
Studio: Pierrot
Source: Manga
Rating: R - 17+ (violence & profanity)
Synopsis:
Many years ago, humans and demons lived in harmony. But that unity ended when demons started attacking humans and plotted a mission to unleash Gyumao—an evil demon imprisoned for thousands of years. Now, Genjo Sanzo, a rogue priest, must team up with three demons—Sha Gojyo, Son Goku, and Cho Hakkai—and embark on a perilous journey to the west to stop these demons from resurrecting Gyumao and restore the balance between humans and demons on Earth.

(Source: ANN)