Mamono Hunter Youko
English name: Devil Hunter Yohko
Genres: Comedy, Fantasy, Horror, Supernatural
Type: OVA, Episodes: 5
Aired: Dec 1, 1990 to Jul 1, 1995
Studio: Madhouse
Source: Original
Rating: R+ - Mild Nudity
Synopsis:
Yohko Mono is a regular girl making her way through high school--until she learns that she is the 108th successor to a line of warriors charged with defending the earth against demons. Eventually she must fight her ultimate battle against the demon who started it all. 

(Source: ANN)