The Study The purpose of this study is to examine how and why constant hits to the head or concussions cause chronic traumatic encephalopathy in retired NFL players. It is assumed that repetitive brain impacts in the NFL sport are the sign of the clinical symptoms observed in CTE (Gavett, Stern, & McKee, 2011). Research Method The study design was a cross-sectional, control case study. A cross-sectional study would examine the relationship between concussions and CTE in retired NFL players. The data collected about concussion will be used to determine what happens to players only after retirement. Sampling In this cross-sectional study, a sample of participants will be randomly obtained among the retired NFL players. The retired NFL athletes shall be recruited from local centers. The NFL association local chapter would be requested to inform retired NFL players about the study. To get a reasonable number of retired NFL players for the study, recently 50 retired players aged between 41 to 65 years would be recruited. The institutional review board will have to approve the study to ensure that it adheres to the required ethical standards on human participation. All respondents will have to provide written informed consent to take part in the study. All players will undergo a standardized assessment by a certified psychiatrist. The assessment will focus on current activities (life after retirement), medical condition, and psychiatric history, as well as any family history involving neuropsychiatric conditions, including Alzheimer’s disease and dementia. All information about retired NFL players’ history of concussion would be collected from any official register of the NFL Injury Surveillance System (if available) and self-report. They will also complete the 17-item Hamilton Depression Scale (HAM-D). Participants would undergo laboratory screening assessments and structural imaging scans, either MRI or CT (magnetic resonance imaging or computed tomography) to identify other possible causes of mental conditions, such as tumors and stroke. Control participants would also be recruited using advertisements targeted at the locals. The screening will be conducted to ensure a stable health condition. Any control participants with cases of concussions would not be included in the study, as well as any other control participants who have a history of engaging in contact sports with hard blows, such as wrestling, boxing, college football, reported neurologic or psychiatric conditions and cognitive challenges. Once healthy control participants have been identified, they would be matched on various parameters, including age, educational achievements, and IQ to the sampled retired NFL players who have taken neuroimaging assessments and included in the final sample for the study. Further, control participants would be excluded based on substance use, traumatic brain injury, and the use of anti-inflammatory drugs. Instrumentation The main goal of the survey questionnaire would be to collect data to answer the research question. Also, the data would demonstrate how the retired NFL players’ cases of concussion and ECT differ from the control participants. There are general symptoms, such as back pain, headache, seizur