Introduction The biological perspective on entrepreneurship is an understudied topic that has only begun to grow in the scientific community in recent years. Nofal et al. decided to explore in which way biological factors link to entrepreneurship and how the former affects the latter. They systematically analyzed academic works that explore the linkage between entrepreneurship and aspects of biology, such as “genetics, physiology, and neuroscience” (Nofal et al., 2021, p. 61). The authors mention that their primary methodology was a review strategy (Nofal et al., 2021). They found that genetics explains 42% to 48% of the variance in entrepreneurship (Nofal et al., 2021). They also discovered that testosterone, cortisol, and epinephrine are highly associated with self-employment (Nofal et al., 2021). The authors describe that entrepreneurs make decisions more efficiently and are more inclined to explore. Moreover, the mental connection between the entrepreneur and the venture is similar to that of a parent and a child (Nofal et al., 2021). The article’s authors also offer readers four hypotheses of how biology affects specific actions related to entrepreneurship. They also discuss the presented systematic review and topics for future research. Gaps in the Literature As noted above, the biological perspective in entrepreneurship theory is still a new topic, which has only recently begun to be addressed. Nofal et al. (2021) try to fill these gaps in the biological entrepreneurship theory by summarizing and organizing a large amount of data from other scientific papers. It is important to note that the article also partially covers the topic of biological theory in management. Interesting Facts and Stimulating Ideas In the article, Nofal et al. presented some interesting ideas and facts. For example, one such point is that “a single nucleotide polymorphism in the dopamine receptor genes to be associated with entrepreneurship using a candidate-gene study” (Nofal et al., 2021, p. 65). The researchers also presented a stimulating idea regarding the mechanisms of how biology relates to entrepreneurship. According to Nofal et al. (2021), “biology may moderate the relationship between environmental factors and the tendency to engage in entrepreneurship” (p. 70). Combining biological and social approaches may become a practical methodology for researching entrepreneurship. The same theoretical framework already exists in psychology and is called behaviorism. Concerns with the Claims There is one major concern about the claims presented in the systematic review by Nofal et al. It is a bias against genome-wide association studies (GWAS). It is essential to note that the authors substantiated and explained their skepticism toward this research method and even suggested how to correct the data obtained by this approach (Nofal et al., 2021). It seems that authors are more likely to trust data from candidate gene studies that are irreproducible than data from GWAS. It partially contradicts the scientific method, which gives rise to concerns about the objectivity of the information and conclusions presented in the article. Similarities Reported in the Literature Other studies support the fourth hypothesis about the mechanisms of connec