A 50-year-old married man with a family of three children presented chronic hepatitis C that developed to cirrhosis. Hepatitis C was linked to “intravenous drug used in 1960’s and trauma treatment involving several transfusion in 1975” (Schiff 2004, p. 183). Cirrhosis became complex due to “bleeding esophageal varice, but endoscopic banding intervention was successful in 2001” (Schiff 2004, p. 183). The patient later had ascites and hepatic encephalopathy complications. A computed tomography conducted in “November 2001 showed a 6×6.5x7cm mass lesion in segment 7 of the liver (fig. 3), which later increased in size to 11.2×9.2×5.8cm on a repeat CT scan two months later while serum alpha-fetoprotein (AFP) was above 16,000ng/mL” (Schiff 2004, p. 183). Introduction Hepatocellular carcinoma (HCC) is the most “common main liver cancer and the fifth most widespread cancer worldwide with a poor prognosis and it is the third most prevalent cause of death from cancer” (Ghanaati et al 2012, p. 167; Hennedige, Tiffany and Venkatesh 2012, p. 530). Some studies have recorded that HCC is mainly common in Asia where there are rampant cases of hepatitis B and C infection. The main risk factor for HCC is chronic hepatitis B virus infection (Carr 2012), which could be severe in densely populated regions (Ghanaati et al. 2012). Poor diet and metabolic factors may also influence prevalence of HCC (Abby and Zhu 2009). The condition is common in men aged between 30 and 50 years of age (Yang and Roberts 2010). These authors also observe that HCC diagnosis mainly occur in advanced stages, which make it contribute to high incidence and cases of fatality. Moreover, this later diagnosis also reduces effective use of curative treatments. Early diagnosis and surgical resection together with local ablation are effective in enhancing conditions of patients with HCC. Imaging has critical role in determining the diagnosis of HCC. HCC has many imaging approaches, which include “ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET) and angiography” (Hennedige and Venkatesh 2012 p. 530; Ghanaati et al 2012). These approaches are effective in diagnosis of patients with chronic liver problems and a possible HCC case. Imaging helps in “screening, diagnosis, medication planning, patient management, and observation after treatment” (Hennedige and Venkatesh 2012 p. 530). In the case study, one can observed that HCC management is difficult because of the changing nature of the condition, factors that affect cirrhosis, and therapeutic challenges (Ghanaati et al. 2012). Surgical interventions and liver transplant have been effective in managing HCC. However, not all conditions of HCC may require surgical resection. Thus, non-surgical interventions are common because of “multifocal diseases, proximity to the vital vascular or biliary structures and the insufficient functional hepatic reserve in cirrhosis” (Ghanaati et al. 2012 p.168). In the absence of surgery, radiology options, such as transarterial chemoembolization (TACE), radiofrequency ablation, and microwave ablation (Firouznia, Ghanaati, Jalali and Shakiba 2011) are common in managing HCC (Schiff 2004). Anatomy The liver is the maj