Antibiotic drug resistance by parasites has become a very great challenge in the realm of medical research and disease treatment. The observed antibiotic inefficiency can be attributed to new trends of drug-resistant mechanisms displayed by recently evolved pathogenic parasites. If these drug-resistant trends are not urgently combated, human health may revert to the Iron-age era when there was no cure or prevention for diseases of the day. As a way of shining a limelight on antibiotic drug resistance, I chose to discuss the popular health mystery related to plasmodium resistance to quinine and its derivatives. Quinine, a crystalline alkaloid obtained from the bark of the Cinchona tree was discovered to possess antipyretic and anti-malarial as well as anti-inflammatory properties early in the 17th century. It is known to be the first remedy for malaria treatment available at the time, particularly due to its therapeutic potency in destroying Plasmodium falciparum : the most virulent Plasmodium strain. It was also found to be a very strong antibiotic destroying other malaria parasites such as Plasmodium vivax , Plasmodium malariae , and Plasmodium ovale which are the main malaria-etiological agents within the tropical regions. Since its discovery by the Quechua Indians of Peru and Bolivia, quinine and its derivatives have been in use for the effective treatment of malaria diseases until recently when some Plasmodium strains evolved to confer resistance to quinine drugs (Olasehinde, 2011). Great breakthrough had been achieved through industrial synthesis of synthetic quinine drugs such as Chloroquine, proguanil, Fansidar, and Atovaquone: which contains sulfadoxine and pyrimethamine as the active antimicrobial agents. These are commonly referred to as Sulfadoxine-Pyrimathamine antimalarials (SP). Of late, Plasmodium parasites have developed resistance to SP’s and therefore they are no longer used as First-line drugs in the treatment of malaria. Plasmodium parasites are believed to have undergone adaptive evolution to counter antimicrobial effects of quinine and its derivatives. Quinine resistance by plasmodium has been found to have occurred due to two major reasons. The first is administration of sub-lethal quinine dosage by patients suffering from malaria diseases. Due to exposure to low potent amounts of quinine, plasmodium parasites produced anti-quinine proteins which conferred them with quinine drug resistance. Secondly, Plasmodium parasites are believed to have formed a drug efflux mechanism over time that continually pumps quinine from the body of the parasite so as to prevent it from reaching lethal levels that can kill the parasite (Packard, 2007). These mutant strains evolved further to develop total resistance to virtually all quinolones. Resistance of Plasmodium to quinine and its derivatives has brought adverse consequences to human health and the medical field in general. Due to total resistance to quinine antimalarials by plasmodium, the disease has become hard to treat thus deaths caused by malaria are on the increase particularly within the tropical regions. The greatest groups at malaria risk are children under five years of age and pregnant mothers. In fact, malaria is currently the leading cause of infant deaths (Packard, 2007). To combat this rapid drug resistance, a change of antimalarials chem