Smoking rates have increased and remained higher among patients with mental disorders when compared to those without these illnesses. This paper reviews literature on implementing smoking cessation among patients with psychiatric illnesses, while presenting statistics and findings of various scientific studies. The specific literature touches on high tobacco use rates and limited quitting attempts, successful methods, sustaining cessation effects, and barriers for practitioners and patients. In addition, the review will include the strengths and weaknesses of the evidence presented in the literature while identifying gaps and limitations. The 5A’s smoking cessation model is the foundation of the quitting process at a healthcare center. The 5A’s are Ask, Advise, Assess, Assist, and Arrange (Martinez et al., 2017). The model involves five steps: asking patients about their smoking status, advising smokers to quit, assessing quitting willingness, assisting smokers through referrals and treatment, and arranging follow up to support cessation (Martinez et al., 2017). While the model is effective in identifying smokers and facilitating cessation, health workers only perform the first three steps and neglect the last two (Martinez et al., 2017). During assisting and arranging stages, the practitioners help smokers to receive various treatments and conduct follow up to ensure sustenance (Martinez et al., 2017). The use of the 5A’s model is effective in identifying smokers and initiating treatment and sustenance interventions. Mental health patients are more prone to abusing drugs, including smoking. The National Institute on Drug Abuse (NIDA) (2020) established that 40% of American smokers are vulnerable populations with mental disorders (MD). Additionally, smokers with MD are reported to smoke more cigarettes per day than those without (NIDA, 2020). Individuals with schizophrenia and bipolar disorder report higher smoking rates than those with other MD (NIDA, 2020; Dickerson et al., 2018). According to Dickerson et al. (2018), patients with schizophrenia reported the highest smoking rates, followed by those with bipolar disorder in the analyzed data spanning across 18 years. Sixty-two percent of schizophrenia patients in the study group were current smokers, while 37% of bipolar disorder patients and 17% of patients without any MD were currently smoking (Dickerson et al., 2018). MD patients use smoking as a solution to mood changes caused by these illnesses. Practitioners attest that MD smokers are more than those without mental disorders are and have lower rates of quitting attempts. In a study involving practitioners, Simonavicius et al. (2017) established that 80.4% of care providers agree that MD smokers are more dependent on nicotine than others are, while 56.7% said that these smokers have difficulties with cessation. The practitioners also reported that 32.2% of their smoking patients have MD, and 41.8% of all documented UK smokers have mental illnesses (Simonavicius et al., 2017). Attempts to quit smoking among mental health patients are limited and only initiated upon hospitalization (Hecht et al., 2019). In addition to limited quitting attempts, smokers with MD have a higher risk of relapse than those without (NIDA, 2020). With the increased smoking rates and lower cessation attempts among MD patients, practitioners must adopt the best m