Introduction A gastrointestinal disease is a form of infection that affects the gastrointestinal tract (GIT), which is composed of the stomach, the liver, gallbladder, rectum, intestines, and the esophagus, among others (Widmaier, Raff & Strang, 2011). The diseases negatively impact millions of people across the world on an annual basis. Symptoms may vary from mild to debilitating, depending on the disorder involved and the status of the immune system of an individual (Widmaier et al., 2011). They can be grouped into categories, i.e., structural disorders and functional disorders (McCance & Huether, 2013). In most cases, the components of the GIT perform complementary functions, implying that when one component is affected, then the others also are negatively impacted. Therefore, it is important for nurses and other healthcare professionals to understand the pathophysiology and clinical manifestations of various GIT infections, so that they can offer the best therapies (McCance & Huether, 2013). This paper focuses on highlighting some of the dermatological manifestations of gastrointestinal diseases. In addition, I a chart format, it highlights ten GIT diseases, their pathophysiology, and clinical signs. Some dermatological signs of GIT diseases A significant number of GIT disorders is associated with dermatological symptoms. Good knowledge of the relationship between the GIT and cutaneous symptoms is critical in alerting a clinician to diagnose a disorder within the GI tract. The following are some of the cutaneous symptoms that result from GI tract diseases (McCance & Huether, 2013):  1. Periorificial granulomas  2. Acral rash  3. Koilonychia  4. Skin tumors  5. Mucosal hyperplasia  6. Vesicles/blisters/erosions  7. Plaques  8. Vascular malformation  9. Palpable purpura 10. Lichenoid papules 11. Ulcers with undermined borders Ten GIT disorders, their pathophysiology, and clinical manifestations GIT Disease                        Pathophysiology                                                                                         Clinical Manifestations                                                      Familial adenomatous Polyposis     Autosomal inheritance of MUTYH genes                                                                      * Formation of adenomatous polyps on the epithelium of the large intestine Peutz-Jeghers Syndrome             Mutation on the STK11 gene located on chromosome 19 that leads to nonfunctional proteins                  * Benign hemartomatous polyps in the GIT                                   Juvenile Polyposis syndrome        Autosomal inheritance of BMPR1A and SMAD4 genes, leading to the production of altered proteins            * Appearance of multiple juvenile polyps in GIT                            Cowden Syndrome                    Loss of function or mutation in the PTEN gene, resulting in the production of altered protein products    * Multiple tumor-like growths called hamartomas                            Bannayan-Riley-Ruvalcaba syndrome  Autosomal inheritance of PTEN genes that results in the formation of altered proteins                     * Multiple subcutaneous lipomas                                                                                                                                                                                         * Macrocephaly and he