Introduction Hyperthyroidism is a medical condition that occurs when the thyroid gland becomes overactive and produces abnormal amount of the thyroid hormone. Thyroid gland is located in the front of the human neck and functions by releasing hormones that control multiple processes and systems, such as metabolism, nervous system, body temperature, and weight. Considerably, hyperthyroidism could emerge in various clinical diagnoses and signs, including unintentional weight loss, rapid heartbeat, abnormally increased appetite, nervousness and anxiety, sweating, tremor, difficulty sleeping, and changes in menstrual patterns among females. The complexity with hyperthyroidism in this case is also explained by mimicking the symptoms of other diseases, which could be hard to clinically differentiate, eventually leading to the inappropriate diagnoses. Henceforth, it is further considered that biostatistical analysis is required to determine how specific methods and approaches could be utilized to address the issues of hyperthyroidism, using the evidence proposed in an academic article and associated analysis of recent healthcare interventions. Specific theoretical consideration and methods are further described below to lay down the ground for relevant conclusions on the subject. Clinically, hyperthyroidism is diagnosed when the thyroid gland produces too much of thyroxine and triiodothyronine hormones that are important for the human body function. Most commonly, hyperthyroidism is caused by the autoimmune disorder known as Graves’ disease (Fukao et al., 2020). Under conditions of such disorder, human body produces a specific antibody protein defined as thyroid-stimulating immunoglobulin (TSI) that provokes thyroid gland to produce more hormones. Another clinical reason of hyperthyroidism is known as toxic multinodular goiter, which denotes the nodules existing in the thyroid gland that also cause excessive amount of the hormone production. This syndrome could be also enhanced through the thyroid gland inflammation as a consequence of a virus or the immune system issues, temporarily causing the increased hormone output. Finally, hyperthyroidism is frequently observed among patients who consume too much iodine either from food or supplements, or take medications that contain iodine as a part of regular treatment. Hyperthyroidism also has some outstanding clinical representations pertinent to specific populations and comorbidity effects. First, hyperthyroidism is more frequently observed among females rather than males within the 5:1 ratio, with 2-5% of all females affected by the condition during the lifetime (Adedarian et al., 2018). Most frequently, females are affected by hyperthyroidism during the pregnancy period, which is explained by hyperactivity of other body systems and changes in metabolism. Second, hyperthyroidism in some cases is supplemented with the comorbidity syndrome known as the Graves’ ophthalmology often observed among smokers. Graves’ ophthalmology is a disorder that makes human eyeballs to protrude beyond the protective orbits, causing the problems with dry eyes, eye tearing, and light sensitivity among the patients. Finally, hyperthyroidism is mostly diagnosed