Introduction Health care functioning and the performance of particular stakeholders in the overall health care system are subject to national and state legislative rules. The regulations of the performance of Advanced Practice Nurses (APN) are imposed by the State Boards of Nursing, which generate and disseminate the requirements for APNs’ licensure, certification, qualifications, and other issues related to organizational and educational spheres. Given the allocation of the regulatory responsibilities to each state separately, there are significant differences between states’ regulations, which predetermine the specific features for APN practice based on their location. In particular, the present paper aims at comparing and contrasting APN practice regulations of the State of New Jersey and the State of Hawaii. While both states’ APN regulations have similar application requirements and certification, the terms of prescription authority, collaboration agreement requirements, nursing compact, and some practical implications. The paper is designed to present an issue-by-issue comparison of the features applicable to APN practice regulations in the two states to identify the most significant differences and similarities. Background Comparison: Definitions, Educational Requirements, and Licensure The definitions of APN in the regulatory documents of both states pertain to the same characteristics. Both states define APNs as individuals performing nursing practice according to the state licensure and certification (Hawaii Board of Nursing, n. d.; New Jersey Board of Nursing Law, 2020). The nursing practice, in its turn, is also similarly defined by both regulatory documents, with the same categorization of practice as registered nurse and practice as licensed practical nurse. A difference in definitions is the title that is used for the identification of APNs. Indeed, the Hawaiian regulatory document refers to these individuals as Advanced Practice Registered Nurses, while in New Jersey they are titled Advanced Practice Nurses (Hawaii Board of Nursing, n. d.; New Jersey Board of Nursing Law, 2020). Moreover, the New Jersey Board of Nursing Law (2020) specifically states that “whenever the titles or designations “nurse practitioner,” “clinical nurse specialist” or “nurse practitioner/clinical nurse specialist” occur …, the same shall be deemed to mean or refer to the title or designation “advanced practice nurse” (p. 22). Therefore, the New Jersey State regulations are more transparent as per the professional titles implied in the designation APN. The educational requirements that are necessary for a nurse to be recognized as an APN are similar in both compared states. The minimum requirements related to the level of educational degree are that the individual is expected to have “completed an accredited graduate-level education program” (Hawaii Board of Nursing, n. d., p. 7). However, only the Hawaiian regulatory body exemplifies a Master’s degree or a program that leads to a Master’s degree as a requirement. The New Jersey regulations imply that the applicants for APNs must have graduate educational degrees. In terms of certification, in Hawaii, the document regulating APN practice clearly lists “registered nurse anesthetist, a nurse-midwife, a clinica