The world is bent on addressing issues related to infectious diseases, resulting in less focus on other diseases that are equally fatal such as sickle cell disease (SCD). Sickle cell disease is a monogenic disease, which results from an error in a single gene, and it affects millions of people all over the world. The World Health Organization (WHO) indicates that 10 out of 1000 neonates have a single gene disease. However, the global burden of each disease has not been accurately determined, largely due to few researches about this disease (Centers for Disease Control and Prevention, 2011). The SCD is common in “Sub-Saharan Arica, India, Saudi Arabia, Cuba, South and Central America, and some Mediterranean countries” (World Health Organization, 2014). Investigating sickle cell anemia is very important in nursing practice because it aims at improving health services through evidence-based practice (Polit & Beck 2012, p. 25). Individuals with sickle cell anemia experience vaso-occlusive episodes associated with the polymerization of hemoglobin. Sickle cell disease pain is the peak of this disease, and many emergencies results due to this pain. In a recent study by Morris et al. (2013), analgesics and hydration were shown to have been the main mode of therapy for a long time, but this study showed effectiveness of opioid. There is need for more novel therapies to help in the management of sickle cell disease pain. The novel therapy of concern in this discussion is the integration of behavioral and opioid in comparison to the use of opioid alone. What is the socioeconomic status of children with sickle cell disease pain? Only participants who have received a pneumococcal vaccination will be included. According to Polit & Beck (2012, p. 77-78), it is necessary to consider the factors that may impede researchability of the research questions. The feasibility of this question may seem unachievable for children, who have no material property added to their names, but they will acquire the social status of their parents. In addition, people may not be willing to disclose information on their income; thus, indicators such as occupation, residential area and apparent expenses like education cost will enhance the feasibility of this question. Assistance from experts in this field will be sought to help in the making o decisions about executing this planned study. What are the demographic characteristics of children with sickle cell disease pain? This question is achievable and aims at defining the people affected based on age, ethnicity and gender. This is the most feasible question that is based on observation and hospital records for date of birth. What is the effect of integrated mild opioid use and behavioral management of vaso-occlusive pain in children with sickle cell disease pain? This question is feasible because it is based on indicators such as pain scores and days spent in the hospital. What is the effect of opioid use in the management of vaso-occlusive pain in children with sickle cell disease pain? Once a good rapport is developed with the participants, they will reveal their experiences. Use of therapy will help alleviate pain; thus, they will be in a position to respond to questions. What is the mo