Abstract Depression in Adolescent stage is one of the most rampant and overlooked problem in our present society. Regrettably, females are the common victims of depression in the adolescent stage. The probability of women suffering from depression in the adolescent stage is higher than men. An individual suffering from depression normally exhibits certain symptoms. These include self injury, inactiveness, attempts to commit suicide, or lack of appetite. Nevertheless, there are numerous therapeutic techniques that can be used to treat depression in female adolescents. These range from guidance and counseling, medication, or a combination of the two. However, even with treatment, the likely hood of subsequent depression is still high. Introduction Depression can be defined as acute state of melancholy coupled with reduced vitality and bodily symptoms. Depressions occur in different forms and are part and parcel of human life (Brent & Poling, 1997, p. 2). There is no human being in this world that has undergone all stages of life without experiencing stress, anxiety and sadness. Regrettably, the most common victims of depression are those in adolescent stage. According to Pearse (2004, p.3), one in every four adolescent have suicidal ideations, and by the end of secondary school one in every ten adolescent has attempted to commit suicide. The main aim of this essay is to explore depression among the adolescent females, symptoms of depression, and several treatment options available for these individuals. A study conducted in England on a sample of 375 adolescent females between the ages of 11 to 16, revealed that the likeliness of depression increases with age. The results of this study showed that the probability of depression in a 16 year old adolescent is higher than an 11 year old adolescent (Sand, 1998, p. 4). Depression in female adolescent is attributed to many factors. A number of psychologists attribute this to the self defeating belief among the female gender. In other words, women are the most vulnerable people in the society; they are more likely to be abused, made to feel weak, and defenseless (Myers, 2004, p. 2). Dr. Myers (2004, p.3) also explains that females responds much stronger to depression compared to men. He states that when women are encountered with challenges, they tend to think while men tend to act. This explains why men are more likely to succumb to negative events than women. Women usually fret or act anxiously to depression while men revert to drinking, delving into work or other negative activities. Many studies have shown that depression or mood disorder run deep in the family. The danger of developing major depressive disorder increases when you have people suffering from depression in the family (Dunn & Goodyer, 2006, p.217). Causes and symptoms of depression among the female adolescents Scientific studies have found that depression can also be passed through genes from parents to siblings. Genes influences certain biochemical reactions in the brain which affects individual behaviors. Burkitt (2000, p. 4-5) explains the difference between depressed and non depressed brain. Serotin, norepinephrine and two neurotransmitters are