The Major Histocompatibility Complex (HMC) pertains to the interconnected genes located at the shorter arm of the chromosome. (Twyman, 2003) It is contained in the cell surface and is responsible for lymphocyte recognition and antigen presentation. Individuals with the same MHC bearing can exchange grafts more successfully than those MHC non-identical. One probable cause is that a series of unique MHC molecules is evident in every individual. There are a hundred different types of MHC however a person can only retain four MHC both came from each parent. A spliced skin or organ coming from unlike MHC activates the cell destruction of the immune system. (Twyman, 2003) However, there are cases wherein non-compatible transplantation can be successful. In the study on the inbred strain of mice, the b and the k are haplotypes mate, progeny are b/k, and can accept grafts from either parent, though a parent cannot accept progeny graft. In outbred population (high polymorphism), there is only a 25% chance of identical MHC haplotypes in siblings. Parents are always mismatched with kids. Even with the absence of a well-matched donor, transplantation may be successful. (Goodsell, 2005)Now in order to quantify class II MHC the compatibility between donors and recipients, MLR is being applied. The lymphocytes of the donor are being x-irradiated or treated with mitomycin C as a stimulator cell which would represent the graft cells. Yet if there is incompatibility, the responder cells will be activated by the foreign MHC. Thymidine is used to measure the degree of MHC differences. (Dorak, 2007) Several procedures however can mediate graft rejection. Peter Gorer instituted the discovery of MHC using inbred mice as the subject of the study. He started with the transplantation of antibodies from one strain of mice to another to identify a certain group of proteins associated with the red blood and white blood cells. Furthermore, he discovers that a single tumor from mice can be transplanted effectively to a group having the same allele and cannot do so to a group different from the allele. George Snell followed the same discovery. Preconceived by the idea that some genetic factors strongly affect an individual tissue to reject another tissue, he began studying inbred mice to validate his idea. He then produced a strain of mice so that he can isolate histocompatibility genes. The research came by uncovering the location on the chromosome of that specific gene that played an important role in controlling resistance to tissue grafts and labeled it as a major histocompatibility complex. (Goodsell, 2009) During the succeeding years, French Immunologist Jean Dausset and later Baruj Benacerraf discovered that the body has the ability to respond to a particular antigen and that interaction of the T cells and B cells are dependent on the MHC. Such that to generate an effective immune response, both cells must have to carry the same MHC antigens. MHC is divided into two main classes, Class I and Class II. Those classes are under the Immunoglobulin Supergene Family which is a cluster of molecules that covers the T-cell receptors, immunoglobulins, CD4, and CD8. In the broader sense, both classes of MHC genes preset the so-called human leukocyte antigen (HLA). (Twyman, 2003). MHC Class I. The molecules belonging to this class are comp