Abstract Research denotes the movement of the world toward development of a global virtual village where e-commerce is the heart of the interactions and activities that are conducted by businesses and other organizations across the globe. However, it is important to note that the reality of attaining a global virtual village are highly dependent on the ability of integrating the cultural variations in e-commerce technologies to reduce the negative influence of culture on the development and deployment of e-commerce initiatives across different cultures. This paper explored the interplay between cultural values and e-commerce adoption. The paper focused on bringing out the main issues that concern e-commerce and cultural values. In the research, it came out that culture has a significant influence on people, thus culture highly influences the behaviour of people when it comes to the acquisition and use of web-based technologies under the e-commerce platform. Introduction E-commerce is a concept that is highly embraced in the modern economy. It has been developed from the availability of web-based technologies and tools that help in easing practices of administration in different realms of business and administration in the contemporary society. As a substantial number of individuals and organizations embrace technology, a section of people have come out to criticize the influence of e-commerce on culture. One reason that is given by the opponents of e-commerce, particularly in relation to cultural attributes, is that it results in total erosion of culture. The question that ought to be explored when talking about the relationship between e-commerce and cultural values concerns the impacts of e-commerce on cultures. What are the considerations of cultural values in the course of applying e-commerce in the society? It is, thus, important to conduct research to ascertain the interplay between e-commerce and cultural values in the contemporary society. This paper explores the impact of culture on e-commerce. Of greater focus in the paper is the explanation of critical issues that revolve around adoption and enforcement of e-commerce practices. The paper also brings out issues of cultural values and norms and how they affect the establishment of e-commerce platform in the society. In this research, the term e-commerce refers to the process of exchanging products, services and information through the internet. It also refers to adoption of web-based technologies in management. Culture refers to the beliefs and ways of living of different people as dictated by the environment in which they live. Integration Using E-Commerce And The Challenge Of Culture A number of researchers have been keenly following developments amidst the acceleration of the pace at which e-commerce is being adopted in different organizations and institutions in the current society. Of greater interest has been the response to the question about the possibility of maintaining the indigenous cultural and social structures in the contemporary environment that highly supports adoption of information technology in its activities. The development and the use of information and communication systems have an impact on the cultural structures and norms of the society