The Patient/Population, Intervention, Comparison, Outcome, and Time PICO(T) framework provides a used tool that can inform the design, development, and implementation of effective, patient-centered care plans. According to Boswell and Cannon (2018), the intended goal of using the PICO(T) framework is to create a robust question that can provide clear guidance to the search for evidence. Consistent with this perspective, a well-formulated PICO(T) question can provide a strong foundation for nursing students and practitioners who are starting to integrate evidence-based models into practice. In this paper, I draw on existing literature and the PICO(T) framework to define a practice issue facing patients with posttraumatic stress disorder (PTSD). The paper also presents sources of evidence for answering the research question and provides a brief explanation of the findings and their relevance. Applying PICO(T) Framework in Caring for Patients with Stress and Depression The practice issue of focus in this paper is to design and implement patient-centered care practices for effectively managing mental health problems such as stress, anxiety, and depression among PTSD patients admitted in nursing homes that are outside of conventional pharmacological interventions. The PICO(T) question is: Is Mindfulness-based stress reduction (MBSR) intervention more effective than pharmacological therapies in managing symptoms such as stress, depression, and anxiety in patients with PSTD? The intervention approach identified in this paper is the mindfulness-based cognitive therapy, a meditation technique that emphasizes training people or patients to focus their attention on mental processes and aspects such as thoughts, perceptions, feelings, emotions, and other sensations as they appear (Davis et al., 2019). The population under investigation includes patients with PTSD symptoms such as anxiety, depression, and stress in outpatient settings. The research process will focus on only factors related to care in outpatient settings without accounting for the sociocultural, political, and economic status. Identifying Sources of Evidence Reviewing previous research and existing literature can help identify relevant evidence that could be potentially effective in answering a PICO(T) question. MBSR is a non-pharmacological intervention for a range of mental health problems. This treatment approach aims at promoting relaxation and achieving a higher level of sense of wellbeing by integrating mindfulness meditation and yoga (Bishop et al., 2018). Numerous studies have examined the efficacy of mindfulness-based programs in managing psychiatric conditions in different settings. In this section, I explore three primary research studies reporting on the efficacy of MBSR on PSTD. Davis et al. (2019) undertook a multisite randomized controlled trial (RCT) to examine the effectiveness of MBST in treating PTSD among veterans. An RCT conducted by Bremner et al. (2017) examined 17 veterans to establish how MBST impacts PSTD symptoms among veterans. In a related mixed-method feasibility study, Müller-Engelmann et a. (2017) examined the efficacy of MBSR) as a Standalone treatment therap