Bipolar disorder is a prevalent psychiatric disease characterized by range of elevated mood disorders often referred as mania. Depression commonly accompanies these mood disorders depending on the severity of the disorder. Bipolar spectrum, that is, the range of this disorder lies within three broad categories: bipolar II, cyclothymia, and bipolar I. this spectrum depends mainly on nature and asperity of the mood episodes that one goes through. This disorder becomes full blown in the late adolescence or in some few cases, in early adulthood. Diagnosis relies on one’s experiences together with observable behaviors. Some of the abnormal episodes include distress, disruption, and increased rate of suicide among others. Causes of bipolar disorder include genetic factors and environmental factors, even though in some cases it is associated with positive accomplishments, creativity, and goal nisus. Problems associated with this disorder include stigma, stereotypes, and preconception against victims of this disorder. Unfortunately, bipolar disorder in most cases is misdiagnosed as schizophrenia and this delays its appropriate management. The prevalence of bipolar disorder stands at 5 million people in America alone. This implies that, in every 45 adults, one of them has bipolar disorder. It is difficult to diagnose this disorder because there are no specimen tests with diagnosis relying mainly on observation, and this elevates the probability of misdiagnosis as aforementioned. There are different ways of managing this disorder including mood stabilizers among other psychiatric medications. Practices like psychotherapy find wide application especially in cases where individuals show improved stability in recovery. This paper deals with the different ways of managing bipolar disorder from treatment to any other measure employed towards the management of this disorder. Bipolar Disorder Management Therapeutic Interventions Antidepressants Bupropion This is one of the most efficacious antidepressants and it acts by suppressing neuronal reuptake of nor-epinephrine or noradrenalin and dopamine. 1 Research indicates that, bupropion significantly reduces the symptoms of depression and anxiety within the first weeks of its administration. Apart from the short-term positive results, bupropion has long-term effects and this explains in part why the US opinion leaders have rated this drug highly in terms of bipolar management. 2 Even though this drug may precipitate mania, it is one of the best drugs of treating bipolar disorder and depression. Selective Serotonin Reuptake Inhibitors (SSRIs) As the name suggests, SSRIs promotes serotonin neurotransmission by suppressing neuronal 5-hydroxytryptamine (serotonin) reuptake. 3 This inhibition leads to reduced depression and increases chances of sleep. SSRIs are widely used in developed countries albeit there is limited study on their efficacy. The shortcomings of these drugs include intolerance, development of mixed states and patient’s noncompliance. Tricyclic Antidepressants (TCA) These drugs have short-term efficacy with the combination of lithium. TCA functions to reduce depression even though research work indicates that these drugs