Introduction Galactorrhea is the discharge of milk or colostrums from the mammary gland in the absence of nursing (Slovik, 2009, p.761). This condition is indicative of likelihood of hyperprolactinemia and the related risk for pituitary neoplasm, when abnormal menses or infertility accompanies it. When a patient indicates galactorrhea, it is crucial to inspect for rudimentary pituitary disease. Pathophysiology and clinical indication Ordinary milk production is a result of an interaction of prolactin and mammary glands prepared by progestin and estrogen. Slovik argues that in presence of pregnancy and lactation, the prolactin levels of the pituitary elevates 10 to 20 times (2009, p.761). This condition can occur in an elevated or normal serum prolactin level. The standard normal prolactin serum level in overall laboratories is 20 ng/ml. Thus, there are two contexts of galactorrhea, namely Normoprolactinemic and Hyperprolctinemic galactorrhea. Medical scientists perceive Normoprolactimic galactorrhea as a product of local mammary stimulation or irritation in women having hormonally prepared mammary gland tissue (Giampietro, Ramacciotti, & Mogg, 1984, p.24). Stimulation of the mammary glands may trigger a mild, brief increase in prolactin secretion, although it is not maintained. Majority of cases can be linked to a distance pregnancy or the use of contraceptives. In this situation, the reproductive organs maintain their functions, with menstrual cycle and fertility remaining normal. On the other hand, hyperprolactinemic galactorrhea arises due to excessive prolactin production, attributed to either the failure of hypothalamic inhibition of anterior pituitary lactotrophs or by the formation of an autonomously active pituitary adenoma (Eftekhari, Mirzaei, & Karimi, 2008, p.290). In seldom circumstances, hyperprolactinemia may develop from a reduced prolactin clearance attributed by renal failure. Importantly, even in the setting of elevated prolactin levels, galactorrhea does not develop without estrogen priming of the breast. Estrogen and progestin priming of the mammary glands is prerequisite for development of galactorrhea. Galactorrhea prevails by 80% in premenopausal women. Differential diagnosis Researchers organize galactorrhea differential diagnosis based on whether prolactin is raised and whether the elevation is due to a reduction in hypothalamic inhibition or over secretion due to a functional adenoma. Normally, just 20% of galactorrhea cases indicate hyperprolactinemia. Prolactinoma is the major cause of hyperprolactinemia, amenorrhea, and galactorrhea. Clinician should make sure that there are no cases of pregnancy in women with hyperprolactinemia. Other causes associated with the area of the pituitary are “parasellar sarcoidosis, pinealoma, craniopharyngioma, and empty-sella syndrome” Biller, 1999, p.76). Approximately one third of incidence of galactorrhea and amenorrhea is accounted for by Nonprolactinomic disease, within and about the pituitary (Riordan, 2005, p.34). Sustained galactorrhea after childbirth attributes for less than 10% of the incidence of galactorrhea. Drugs that are connected with galactorrhea are oral contraceptives and agents with central dopaminergic-blocking function, including “metoclopramide, haloperidol, and phenothiazines… drugs that partially induce galactorrhea include tricyclic antidep