Introduction: Significance of Innovative Interventions for Controlling Nosocomial Infections Preventing hospital-acquired infections is a crucial step toward facilitating high-quality healthcare services and increasing recovery rates among patients (Centers for Disease Control and Prevention, 2016). Typically defined as the infections that have been acquired in the course of staying in a healthcare or nursing facility, nosocomial infections pose a considerable threat to patients’ well-being since they delay the recovery process and may lead to a number of complications, thus, jeopardizing the patient’s chances to recover successfully. The design of a flexible prevention strategy that can be used to isolate the patients from the factors contributing to nosocomial infections development, as well as increasing awareness rates on the subject matter, is bound to lead to numerous improvements. Considering the issue closer, one must admit that the current approaches toward enhancing the CLABSI management process, while being admittedly sensible, lack a deep insight about the external factors that contribute to the problem’s development. For instance, the fact that the current frameworks tend to embrace only one area at a time needs to be brought up as a primary stumbling block. Although addressing the issue on the level of inventory management is crucial for the control of the procedures and the facilitation of patients’ safety, the framework that will help prevent and handle the CLABSI issues, as well as raise awareness about the subject matter among nurses and patients alike, needs to focus on not only the central line implantation procedure but also the management of the information available to the nursing staff and the patients, the supervision of the latter, the process of collecting feedback from the customers and addressing the emerging problems in a timely manner, etc. Innovative Interventions for Managing Central-line Associated Bloodstream Infections: Description Supporting the National Initiative as the Primary Measure to Be Taken Much to its credit, the Agency for Healthcare Research and Quality (AHRQ) has suggested the national initiative that is bound to reinvent the very concept of CLABSI-related issues management. The tools designed by the organization are bound to serve as the premises for reducing the rates of CLABSI development dramatically. Designed as the measures to address the problem on a national level, the toolkit created by AHRQ can be applied easily to the target nursing setting. The fact sheets, the inventory, and the checklists designed by the organization serve a rather simple purpose; they can be used to raise awareness among the nursing personnel, as well as make sure that the specific guidelines designed for CLABSI prevention are followed to a T. Apart from providing basic guidelines about hygiene and the ways of maintaining it, the initiative strives to reduce the threats associated with the mismanagement of the available nursing resources. Furthermore, the time used to carry out the necessary procedures can be shrunk to a considerable extent, therefore, reducing the patients’ exposure to the threat of CLABSI contraction (see Appendix A) (Agency for Healthcare Research and Quality, 2014). By arranging the inventory located in the central line cart, a nurse will be able to manage