Abstract Depression and heart disease are dangerous and debilitating diseases. Depression can cripple a person’s ability to think and act according to the situation, while heart disease can cause severe damage to a body and lead to death. The presence of heart disease can often lead to depression, as the person has to worry about his life and health every day, knowing that their heart is not as reliable as it used to be. Women are prone to heart diseases and depression more so than men, due to differences in mentality and physiology. The research shows that social and psychological support, age, physical health, and way of life can affect the development of depression at early stages positively or negatively. Introduction Depression and heart disease are not mutually exclusive. These dangerous diseases often come hand in hand, with one causing another or the other way around. Either of these diseases is very widespread among the population and equally debilitating. At the same time, the mechanisms of either disease are not completely understood by modern medicine. While pathological mechanisms of heart disease are relatively well-studied, depression is a much more intricate subject. So far, science can only suggest possible reasons for depression, but mechanisms of how exactly the disease appears, how it works, how it can be prevented, and how it affects the rest of the body are not completely understood. This creates difficulties when trying to establish visible connections between heart disease and depression. Most women in the USA die from heart disease. This is due to the susceptibility of a female body to ailments that serve as the gateway to heart diseases, such as diabetes, blood lipids, and metabolic syndrome. The number of women in the US that have heart disease in some form fluctuates between 6 to 7 million people, out of which approximately 500,000 people die every year (Gregg, 2012). This is a very grim statistic, which only serves to underline the impact that heart disease has on women’s lives. Due to the symbiotic nature of these two ailments, it is not hard to extrapolate that women are in greater danger of depression related to heart disease. The purpose of this paper is to explore the relationship between heart disease and depression in women, analyze how it is affected by other factors, such as age, ethnicity, economic standing, social standing, and culture, and suggest what factors healthcare personnel should be focused on to reduce the appearance and potential escalation of depression in women. Background What is Heart Disease? Heart disease is a collective term used to describe all kinds of diseases that affect the heart in one way or another. Since the heart is one of the most important organs in a human body, any heart-related problems have the potential to escalate and result in death. The most common types of heart diseases are (Pan, 2011):   * Ischemic stroke – this disease happens when a blood clot blocks the vessel that feeds the brain. Without oxygen, the stroke causes brain cells to die, severely debilitating a person or even killing them, if the clot is not found and removed in time.   * Heart failure – contrary to its name, this disease does not always mean complete h