There has been a rising concern about the trend in patient compliance to health care recommendations. This concern for patient’s compliance is more evident on certain health conditions than on others. Barbour, Cohen, Chinnock, Peiperl, and Yamey (2007), argue that approximately half of the patients with tuberculosis (TB) do not comply with their drug prescription. This concern is very critical because noncompliance to treatment lead to disease relapse and subsequent mortality. Qualitative studies, provides the insight into the justification behind noncompliance by listening to the opinions of the patients, caregivers, and care providers. Munro, Lewin, Smith, Engel, and Fretheim (2007) found a wide set of factors to explain noncompliance such as the idea that after one symptom vanish, it is not necessary to finish the regimen. Such findings help a lot in improving TB treatment and in lowering the huge global burden of TB (p.18). Various interventions on TB are available. Directly Observed Treatment, Short-course (DOTS) has enhanced tuberculosis control, although better patient compliance is necessary to stop the global tuberculosis prevalence (Munro et al., 2007, p.19). Further, the authors argue that treatment compliance is an intricate issue, and enhancing treatment outcomes for TB demands a full appreciation of the factors that hinder patients from taking medicine appropriately, and those that motivate them to finish their regimen. Qualitative research is the best methodology to investigate this phenomenon because it examines the attitude and the response the treatment elicit from individuals. On the contrary, a quantitative study only depicts the number of noncompliance and its serious consequences. Thus, a qualitative study provides researchers with the orientation for solving the problem of noncompliance. It is through qualitative study that researcher can identify the weakness of a prescription in terms of inconveniences to patient and drug formulation. For instance, oral formulation is more preferred than injection, while short regimen is preferred to long regimens. With regard to design of this study, I will enroll 100 participants. Of the 100 participants, 30 will be doctors and 70 patients. I will use questionnaires and open-ended interviews respectively. The significant questions were (a) How would you rate patient’s compliance to a specific TB treatment (in a scale of 1 to 10 with 1 signifying least compliance while 10 the most compliance)? (b) Are you comfortable with your TB prescription? What aspect of the treatment do you not like? The qualitative study, a preventive health education programme for osteoporosis lacks hypothesis or a research question. The study just intends to evaluate the level of attention given to osteoporosis and attract attention to this seemingly undermined condition (Whitehead, Keast, Montgomery, & Hayman, 2004). The quantitative study patient self-medication , on the other hand, has a hypothesis that it seeks to test. The designers of the later study belief that self-medication is a useful approach to management of chronic illness. The approaches of the studies are different in terms of the data employed for study. The former study design is retrospective because it involved the assessment of already existing preventive osteoporosis s