Complementary and alternative medicine (CAM) products are any medicinal drugs that are not covered under the standard medical care. These products are used alongside or instead of standard medical drugs. The Food and Drug Administration (FDA) regulation of CAM products has been a controversial topic. Different industry players endeavor to determine what should or not be regulated under the FDA provisions. These products are regulated as drugs, devices, cosmetics, biological agents, or food materials depending on their use. The applicable laws in the regulation of these products the Public Health Service Act (PHSA) of the Federal Food, Drug, and Cosmetic Act (FFDCA), which is popularly known as “the Act” (FDA, 2006). Given that CAM products fall outside the domain of standard medicine, they normally have major pros and cons that should be considered before use. The pros include – CAM products are natural, and thus they are deemed safe for use without serious side effects (Winter & Korzenik, 2017). Besides, these products are used for alternative medicine practices, which focus on whole-person treatments, hence their popularity. However, limited scientific research is associated with these products, and thus they could be potentially harmful, which is the major concern of their usage. CAM products are appealing to patients for diverse reasons. First, most patients with chronic conditions have tried the standard medical care drugs, which may not be effective. Therefore, they opt for CAM products as an alternative. Besides, patients like these products because they are natural. Nevertheless, despite the growing popularity of CAM products, patients may experience some problems by taking them. For instance, due to the lack of scientific research, these products may cause organ toxicity or interact with other drugs to present various side effects, such as diarrhea, allergy, digestion problems, hypertension, and other related problems. Arnica Arnica is a common CAM product used as a pain reliever in most cases. The major brand name is Arnica, but other generic names, such as Arnica cordifolia, Arnica fulgens, Arnica Montana, Mountain tobacco, Mountain snuff, and Arnica sororia are available in the market. Arnica grows naturally as an herb in parts of central Europe, North America, and Serbia. The flowers are extracted and used as drugs due to their medicinal value. Arnica is usually used to relieve different forms of pain including arthritis, muscle pain, bruises, and general pain reduction. The mode of action of Arnica is not fully known. However, two active chemicals – helenalin and dihydrohelenalin, have been associated with their pain-relieving properties. These chemicals work by modifying the activity of blood cells and other substances that cause inflammation. By interfering with these substances, helenalin and dihydrohelenalin reduce the intensity of the pain associated with the inflammation. These chemical compounds are also suspected to initiate immune response towards inflammation and other pain-inducing activities. For instance, a study by Marzotto et al. (2016) showed that Arnica stimulates the up-regulation of genes that function in the expression of macrophages that initiate a cascade of immune system events leading to