Introduction Prostate cancer is synonymous with prostate, a gland found in the human reproductive system. The cancer grows slowly, but some types are very aggressive. The cancerous cells normally spread from the prostate to the other body parts like the lymph nodes. This article intends to review Carter et al’s work on detection of life threatening prostate-PSA velocity (Huggins 210). The Observations Carter et al show that in unselected cohort of men that were enrolled in BLSA, the PSA velocity facilitate access to information early in the disease course related to chances of dying of prostrate cancer. Carter et al study shows that PSA velocity can be used in identification of men with prostrate cancer at a time when either surgery or radiation can be used to contain the disease. They suggest that men with low PSA velocity should be major targets of observation. The study further show that the association of prostate cancer with PSA velocity does not differ between pre-PSA and PSA eras. Moreover, there is no statistically significant relationship between PSA velocity and the date when prostrate cancer is diagnosed. Carter et al findings differ with those of D’Amico et al in that D’Amico et al showed that a high PSA velocity prior to diagnosis and surgery was correlated to increased risk of harboring prostrate cancer that cannot be treated by surgical intervention alone, a thing which Carter et al’s study differ with on grounds that their study show that values above a lower threshold of PSA velocity are prompted by presence of life threatening disease when prospects of getting cure may be there because PSA levels at PSA velocity determination were in a range when men had curable diseases (Carter 1523). Moreover, the PSA velocity in Carter et al study was lower than that of D’Amico (0.35 against 2.0). The difference is attributed to direct increase of PSA velocity relative to PSA level. The implications of Carter et al study included use of single PSA value as an indication for biopsy for men. This approach can detect unimportant cancers or miss important cancers especially if the value is lowered for all men. Low PSA levels would imply that enlargement of prostrate cancer is absent. Carter et al further advances that not all men in BLSA had their serum available for PSA testing and that precise estimate of risk of death from prostrate cancer from this study was small. The Formulated Hypothesis Prostrate specific velocity can be an important indicator of prostrate cancer. What the Testable Prediction of the Articles Were Evaluation of Prostrate Specific Antigen velocity and survival. The Experiments used by Researchers Carter et al study subjects participated in the BLSA a study instituted by National Institute of Aging. A total of 1806 males participated. The subjects underwent medical, physical, and neuropsychological examination after every 2 years. Participants signed a consent form before taking part in the study. At each evaluation, PSA measurements and digital rectal examination were done. Subjects with PSA levels higher than 4.0ng/gmL were subjected to transrectal ultrasound directed prostrate biopsy. Frozen sera samples stored at -70 o C were used to measure