Introduction New health problems are coming up today as time progresses and lifestyles of individuals in the society change. Before the end of the twentieth century, practitioners strictly relied on their knowledge and skills to solve medical related problems in their field. Due to increased complication of these conditions, clinicians find it hard to keep up with the emerging demand for new and improved skills (Melnyk & Fineout-Overholt, 2010, p. 167). As a result, practitioners around the world are adopting different methods to solve emerging problems. For example, most of them conduct randomized tests on patients. The development has raised concerns among stakeholders. Consequently, it has created the need for guidelines that would reduce the inappropriate variations in techniques used by these professionals. In addition, the guidelines are aimed at minimizing harm and optimizing health outcomes among patients receiving medical care (Melnyk & Fineout-Overholt, 2010, p. 186). Surgical infection is not a major issue in medical practice if it is handled appropriately. It can be prevented using basic hygiene practices. However, it may become fatal when ignored. Research shows that about 5% of patients undergoing extra-abdominal surgery develop infections during recovery. The same happens to 20% of individuals undergoing intra-abdominal operations (Bratzler & Houck, 2005, p. 396). The objective of this paper is to develop a detailed guideline for clinical practice in the context of surgical site infections. Students, physicians, nurses, patients, and management teams will find this paper beneficial to their practice and research. Target Audience The parties targeted by this guideline include:   * Patients undergoing surgery from around the world   * Clinicians involved in surgery   * Caregivers dealing with surgery patients Stakeholders Following are the stakeholders: Bratzler D. and Houck P. The two are the authors of “ Antimicrobial Prophylaxis for Surgery: An Advisory Statement from the National Surgical Infection Prevention Project ”. Melnyk, B and Fineout-Overholt, E. They are the authors of “ Evidence-Based Practice in Nursing & Healthcare: A Guide to Best Practice ”. Dellinger, E., Olsen, K, Perl, T., Auwaerter, P., Bolon, M., Fish, D., Napolitano, L., Sawyer, R., Slain, D., Steinberg, J., and Weinstein, R. The scholars have authored an article titled “ Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery ”. All stakeholders possess knowledge, skills, and experience in the medical field. In addition, they are recognized by their respective medical bodies in their regions. Surgical Site Infections The main function of the skin is to prevent entry of pathogens into human bodies. It is noted that chances of infection increase when the skin tears off or breaks. Surgical site infections (SSIs) refer to contamination of wounds obtained as a result of surgical procedure. According to Bratzler et al. (2013, p. 200), the infections are usually caused by bacteria. They result from contamination to the surgical wound. The pathogens that cause surgical site infections are usually from the body of the patient. When this happens, the resulting situation is referred to as endogenous