Introduction It is the great obligation of Christians to love other people despite their religious or national identities and have compassion towards them. One of the main challenges of the church today is Islam yet not because it has a small group of radical followers but because there are more than 1.8 billion Muslims in the world 1 . A substantial part of them has never known the truth of the Gospel and thus constitute a people who can be saved and become Christians. The current paper explores a variety of ways in which people pursuing their Great Commission, local churches, and mission organizations can work together to help Muslims see biblical truths. Despite the growth of Islamic fundamentalism, mission organizations must partner with churches in different countries to promote the Gospel among Muslims through charity and debate. Challenges Posed by Islam First of all, it is necessary to list various challenges related to the church’s activity in terms of promoting the Gospel among Muslims, especially in countries where Islam is the dominant religion. One of them is the growing influence of Islamic fundamentalism, which promotes the perspective on the Westerners as aggressors wishing to undermine the Muslim society’s foundations 2 . Essentially, mission organizations venturing to Muslim countries may face aggressive treatment on the part of local religious communities. Additionally, according to research, Muslim-majority nations often implement laws discriminating against Christians, thus stimulating social and religious division. 3 . Therefore, mission organizations and individuals who wish to fulfill their Great Commission in the Muslim-majority countries have to be careful and should not risk their life by going to places potentially dangerous for them. Thus, the concept of cooperation with the churches which were already established abroad in the countries with a considerable share of Muslim population would be a reasonable strategy to pursue such organizations and individuals. The Plan for Working with Muslims The first method in which mission organizations and people pursuing the Great Commission can engage in promoting the Gospel among Muslims abroad is to launch or support a humanitarian aid program with local churches. Countries in the Middle East and other nations with large populations of Muslims often have a low quality of life, especially outside the urban areas. Thus, mission organizations can cooperate with the local churches and provide food and shelter to those in need. As Paul said to the Ephesians, “the words of the Lord Jesus Himself: ‘It is more blessed to give than to receive” 4 . The partnership with the local church will allow the missionaries to go through sociocultural adjustment, necessary for establishing effective relations with the host culture representatives in a faster manner 5 . While sharing of food and shelter will promote stronger ties with the local population and will increase the cultural intelligence and awareness of God’s people who came to promote the Gospel truth. The next step in the work of mission organizations with the local churches would be to introduce the Muslim population to the Gospel by reading and discussing the Bible in their nati