Abstract The ‘population of South Asia accounts for almost 60% of the world’s total population, therefore if the negative effects brought about by misuse of drugs and sexual abuse are not watched, then we will see a general major decline in the world’s overall population. The country is therefore being urged to combat the exclusion of commercial sex workers and Injecting Drug Users (IDUs) to reverse the surging trend of the vice. The term “sexual exploitation” takes several forms, it simply does not stop at pornography, or rape, bride trade, FGM, sexual harassment, incest, or even sex terrorism, but, includes all those acts which tend to dehumanize or commodifies bodies of either men or women. Any activity that is considered a violation of women’s rights particularly regarding sex is classified under sexual exploitation. Such acts are very much alive in South East Asia. This vice, coupled with drug abuse has become not only an Asian affair but a Global concern. The two activities mentioned above are the major contributors to the escalating cases of the spread of the deadly HIV…the foreign men’s involvement is not making things any easier for the “STOP AIDS ” advocates in Southern Asia. This essay paper will highlight the reported effects of the menace in South Asia as well as its diverse impacts on the rest of the world and the necessary steps that can be taken to reverse the upsurge. The State of the Matter The World Health Organization (WHO: Vol, 79, 2008) report has it that, the situation of the HIV/AIDS is worrying. The epidemic is gaining ground and spreading at an alarming rate, thanks to the sex workers and the IDUs. The idea by the commercial sex workers to engage in sex without using condoms or oral sex is a major huddle in the fight against the menace. It is an open secret to say that the foreign sex industries have been implicated in the HIV spread and that the Effect of Western Dominance, Masculine Oppression, Female Subordination, and Male Power in Southeast Asia are marginalizing the voices of the sex workers. These women, due to their low bargaining power, are therefore not able to fight for their rights and will only go for whatever has been demanded of them (Lisa Law, 2000, Pg. 1). Alcohol and other substance abuse can take numerous forms among which are: – Miss use of legal products (for example alcohol and medication), use of illegal drugs (for example bang-marijuana, cocaine, heroin, and so on). Smoking, because its ability to lead to addiction has been classified under drug abuse. In Asia as well as the rest of the world, millions of people are injecting drug users (IDUs) and blood transfer through sharing of infected needles is a major ingredient in the spread of the deadly virus (Open Society Institute, 2004, July). Because the act is illegal, few or none of the IDUs will seek treatment in hospitals making them more vulnerable to HIV and its effects, this alone is scary without mentioning the role that their crossover with the prostitutes plays in the spread. Apart from the IDUs, those who smoke (crack and Cigarettes) stand high chances of exposing themselves to HIV/AIDS. The burns, cuts, and blisters that they suffer from on their lips while smoking due to the intense heat from the vaporizing smoke create open wounds that end up contaminating the stem of the metal pipe, which in turn is passed to the next smoker. If either of the persons ha