Abstract Uterine cancer is a major health problem affecting women in the world. Certain risk factors have been observed to increase the chances of developing this condition. Obesity is one of the risk factors associated with uterine cancer. The number of obese people in the United States is on the rise. Proper knowledge of obesity should be the first step towards dealing with uterine cancer. This paper, therefore, gives a detailed analysis of obesity as a risk factor for uterine cancer. Introduction The “uterus in women is hollow in nature and is located in the pelvis” (Arem & Irwin, 2013, p. 635). The uterus (also known as the womb) plays a unique role in supporting the development of the fetus after conception. Uterine cancer occurs when there is an abnormal growth of various cells comprising this hollow organ. Arem and Irwin (2013) argue that many cancers of the uterus start in the inner lining of the womb called the endometrium. The cancers are classified as adenocarcinomas because they are associated with mucus-producing cells (MacKintosh & Crosbie, 2013). Although the main cause of uterine cancer is unknown, studies have linked the condition to various risk factors such as genetic composition, obesity, and the increased intake of estrogen. This discussion focuses on obesity as one of the risk factors for uterine cancer. Pathogenesis Obesity is a condition in human beings associated with increased body fat content. The condition is one of the health concerns affecting many people today (MacKintosh & Crosbie, 2013). Unhealthy tissues in the body produce excess hormones such as estrogen. Any increase in estrogen in the human body is widely linked to different cancers. This fact explains why obese women will have a bigger chance of developing uterine cancer. As well, such individuals will have abnormal levels of insulin-like growth factor-1 (IGF-1) and insulin in their circulatory systems. This situation results in insulin intolerance or hyperinsulinemia (Arem & Irwin, 2013). Therefore, intolerance has been associated with the development of different tumors in the body. Obese individuals tend to have subacute inflammation (Arem & Irwin, 2013). This kind of inflammation creates the best environment for malignancy. The body is known to produce various cell-growth hormones to boost development. However, fat cells tend to produce excess adipokines. Increased percentage of this hormone results in reduced cell growth (Arem & Irwin, 2013). One of these adipokines is leptin. Higher levels of leptin in the body increase the rate of cell division, thereby resulting in abnormal growth. Reduced levels of adiponectin in obese people will result in anti-proliferative effects. Such effects are associated with the development of cancerous cells. Modern studies have shown conclusively that obese people tend to have ineffective immune responses. This means that their bodies cannot resist various pathogens and infections. Such infections might create the best environment for cancer development. MacKintosh and Crosbie (2013) indicate that “increased fats in the body alter the nuclear factor kappa beta system ” (p. 792). This discussion shows clearly that obesity alters (or inhibits) specific functions in the body, thereby creating new opportunities for cancerous cells to grow. Contribution of th