DNA profiling has become a widely used technique to analyze physical evidence as it provides conclusive data that can lead to the conviction or exoneration of a person. This method is instrumental in solving crimes as investigators are able to locate and prove the guilt of a person based on DNA test results (Del Carmen & Hemmens, 2016). For instance, even if a thief wears gloves, he or she is likely to leave certain traces such as hair, blood, or skin particles. These types of physical evidence can be used in the court as every individual has a unique DNA profile, so the findings can help juries make their decision (Robertson, Vignaux, & Berger, 2016; Becker & Dutelle, 2018). Researchers analyze samples found in the crime scene and use databases to identify if any matches occur, so DNA testing helps in locating suspects as well. The available databases are constantly updated, which makes DNA profiles critical for any investigation. This paper includes a brief description of some aspects of DNA profiling based on the case of a robbery and murder of two people. DNA tests are regarded as reliable tools due to sophisticated methodology and informative results. This method was first employed in 1984, and it has evolved considerably since then, although certain gaps and challenges still exist (Taupin, 2018). DNA profiling involves the comparison of samples obtained from the crime scene and the suspect. In such tests, the focus is on alleles that are variations of a gene unique to a person or people related to each other genetically (Taupin, 2017). DNA remains unchanged under various conditions, even when other biological compounds are damaged or destroyed. A small amount of DNA suffices to implement the analysis, which is often crucial due to the scarcity of collected samples. Many methods of DNA analysis have been developed, so specific instruments can be employed under diverse circumstances. Regarding the case of the robbery and murder of a man and a woman, different types of physical evidence can be collected. Blood is often one of the most common types of physical evidence found in the crime scene that helps in solving crimes (Bright & Coble, 2019). The man was injured substantially while the two offenders attacked him. The body of the male victim has scratches and bruises, so it is necessary to look for skin particles and blood of suspects that are likely to be left on the male victim’s body. DNA profiling can be instrumental in identifying the suspects as they had been accused of assault previously. Since they have a criminal record, their DNA profiles are likely to be in a governmental database. The fact that the suspects’ DNA is on the man’s body (his injuries, to be more precise) will prove that the suspects assaulted him. The female victim’s body also has numerous scratches and bloodstains that have to be analyzed as well. The robbers were likely to have certain scratches or bruises as they had a fight with the man. The offenders could injure fingers and fists (or leave skin particles) on the female victim’s body while taking her jewelry or dragging her body to the alley. Apart from blood on the bodies, victims’ clothes can have some physical evidence as wel