Introduction Humerus fractures are damages that affect bone of the upper arm, which bonds the shoulder with the elbow. The fractures in this zone appear in three major forms: proximal, midshaft, and distal humerus fractures. The majority of these fractures occur due to various means, but they are often instigated by falls like in the case of John who sustained a midshaft injury in a road traffic injury. Although most humerus injuries do not require surgery for them to heal, John underwent one. Surgery is always applicable in cases whereby the fragments are far apart. Doctors can conduct diverse orthopaedic surgeries to treat patients with midshaft humeral fracture with one of the common option being the Open Reduction Internal Fixation (ORIF). After treatment, patient with humerus fractures undergo a rehabilitation process that lasts a minimum of three to four months. However, resuming physical activity such as sports like in the case of James may avert the healing process. This paper discusses the rehabilitation of a midshaft humerus fracture by underscoring the underlying pathological processes as well as outlining a treatment line. The paper begins by discussing the ORIF surgery. Open Reduction and Internal Fixation (ORIF) ORIF is a surgery performed on patients to mend injured bone. Open reduction refers to the slitting of the limbs to access the bones and the fix in the right manner. Internal fixation refers to insertion of metal screws or sutures to hold the bone in the right position during the course of remedial. The sutures and screws are left in the body even after healing. This type of surgery is commendable where solely using cast or splint is ineffective. Furthermore, apart from enabling the bone to heal correctly, the procedure reduces pain, reinstates the bone to its usual function, and curbs supplementary injury (Carlan 2007). ORIF of fractures that occur in the humerus is often conducted using miscellaneous techniques. However, the technique applied will depend on the doctor’s experience, the position of the fracture and if the radial nerve is wounded (Zlotolow et al. 2006). Physicians should adhere to the Orthopaedic Trauma Association guidelines when conducting this kind of surgery to properly reinstate anatomic alignment, avoid destroying the soft-tissue to maintain the vascularity to the bone, as well as conducting an accurate firm fixation to enable the patient to have early array of motion and impressive functional healing process (Carlan 2007). If a patient has spiral-patterned fractures, the doctors apply a lag screw fixation to enhance the inter-fragmentary rigidity. Patients should not only just be informed of the benefits of ORIF, but also the risks associated this type of treatment. For instance, during the process some nerves could be injured and hence, alter their performance in the arm. Some patients may develop compartment syndrome that might destroy muscles and tissue in the arm. Other feasible risks include pulmonary embolism, partial healing of the arm, swelling of the arm, and muscle spasms (Gradl 2010). Despite these risks, patients who undergo this procedure are normally taken to a recovery room where they ar