Introduction The risk of infection while operating in any healthcare facility is a challenge to the basic tenets of such an institution in terms of ensuring the wellbeing of people in all nations. In Canada, Zoutman, Ford, Bryce, and Gourdeau (2010) estimate that above 200,000 people contract HAI (Healthcare-Associated Infections). According to their report, 8000 of the infected people die annually. However, the problem equally attracts the attention of healthcare professionals even in other parts of the world apart from Canada. For instance, World Health Organization (2011) reveals that HAIs constitute a universal challenge in all nations. Prevention of HAIs requires cooperation among patients, families, and healthcare staff members while at the same time utilizing the right equipment to manage them effectively. Perhaps, this approach involves mitigating and/or responding to HAIs, which form the fundamental strategies of risk management. This paper discusses how healthcare facilities can utilize the concept of risk management to curb infections in healthcare settings. Transmission of Infection in Health Settings Prescription of appropriate strategies of managing the risk of infection in healthcare settings requires an understanding of the mechanisms through which infections are transmitted (Cruickshank & Ferguson, 2012). Infections involve three aspects, namely origin, manner of spreading, and the existence of a predisposed host (National Health and Medical Research Council, 2013). In healthcare settings, sources of infection include infected patients, their friends, family members, or any other person who interacts with other people within the facilities. Contact, airborne elements, or droplets constitute the three possible modes of transmission of any infection (National Health and Medical Research Council, 2013). Contact transmission takes place in the form of direct or indirect transmission. Direct spread takes place through the transfer of germs that cause diseases from a contaminated person to a susceptible target. Indirect transmission entails the transfer of disease-causing microorganisms via an intermediary formite and/or object. Such objects may include bed tables, toilet door handles, bath tabs, hospital instruments, and bed railings among various environmental surfaces. Droplet transmission takes place whenever respiratory droplets that are associated with sneezing and coughing are exposed to a vulnerable host’s mucosal surfaces (National Health and Medical Research Council, 2013). In some situations, this process may involve any contact with environmental surfaces that contain microorganisms followed by contact with mucosal surfaces of susceptible hosts. Since respiratory droplets do not remain in air for prolonged time akin to their high weight, their dispersal takes place only within limited distances. Airborne infection occurs through the transfer of a nuclei droplet using air as the medium from infected persons to susceptible hosts. In this case, microorganisms have the ability to survive for an extended period in the air while also outside the body of an infectious agent (National Health and Medical Research Council, 2013). Considering the modes of transfer of microorganisms that cause infections through the three main approaches, healthc