Pathogenesis of celiac disease refers to the steady development of celiac disease from the initial stage to the final stages. Celiac disease is a chronic enteropathy disease that is as result of in toleration of the gluten proteins in the body system. This is a severe disease condition, which is rapidly increasing in infection rate as more and more individuals who were silently suffering from the condition are now seeking medication (Branski, 2008). The disease is characterized by considerable morbidity and augmented mortality. In the recent past, pathogenesis of celiac disease has taken a different direction. Through pathogenesis, medics have been able to carry out intense research which has enabled them come up with new strategies in offering treatment to victims of celiac disease. The new novel strategies interrupts progression of the disease by interfering with intolerance of the gluten proteins in the human body through modification of the proteins (transglutaminase tissue [tTG]) strains that are responsible for the condition, hence the tissue connection with HLA Cells is made inactive (King Helm et al, 2003). The food sources of gluten peptide responsible for the celiac disease include bread, bagels, cakes, cereal, and other sort of cookies. These sources are generally food stuff rich in starch which is changed into peptide proteins for body development. The peptide in reference is the transglutaminase (HLA-DQ2 and HLA-DQ8) which is believed to be released during irritation of endomysial auto antigen. This irritation leads to activation of intestinal fibroblast which in most cases results to mucosal conversion with the blood, and the lamina T- cell becomes active in the peptide tissue. This may result in decreased sensitivity and increased intolerance of gluten in the body, and if it persists it leads to the predisposition of auto diseases (Merri Lou Dobler, 2002). Some of the symptoms of this disease include, short stature, cases of Dermatitis herpetiformis among the victims, cases of hyperplasia in the dental enamel, reoccurrence of cases of stomatitis, fertility problems in both men and women, symptoms of osteoporosis and intestinal lymphoma. Other symptoms observed in the celiac victims are neurological disturbances, gluten ataxia and interrelated refractory celiac disease complications Pfeiffer (2008). The serological test conduct in the pathogenesis of celiac disease usually involves blood tests. The blood is usually screened to detect coeliac elements, after which diagnosis and monitoring of the celiac behavior is done. Through screening of blood among individuals, it is possible to ascertain the extent of celiac disease condition within the society. The pathogenesis conducted provides vital information in diagnosis of celiac disorder and in most cases victims are advised to observe a gluten free diet, since gluten peptide protein is the chief cause of this condition (Jones, 2009). Generally, there are two groups of antibiotics that are observed in celiac condition, the gliadlin gluten and reticulum antibiotics. The gliadlin is concerned with endomysial and recticulin is reflected on the kidney and liver organs of the body. During serological testing, gliadin and endomysial tests are usually conducted. This test involves removal of blood cells in order to determine levels of a