Abstract The purpose of this project is to explore the measures for the control and prevention of an infectious disease outbreak that can result in a pandemic. The focus is the hospital setting and the target is medical-surgical nurses. In the hospital setting, the spread of infection is extremely likely due to many contributing factors including exposure rate, patient load, and frequent contact with ill people. Nurses are at a high risk of contracting the disease and spreading it if appropriate infection control protocols are not followed strictly. This project examines the current outbreak of the COVID-19 virus also referred to as the Coronavirus. COVID-19 is spreading rapidly, and the Centers for Disease Control and Prevention (CDC) have declared a state of emergency. Mainly, this project reinforces the infection control and prevention of spread measures that are suggested by the CDC. It also goes in-depth on the role of the nurses and how they can assist in disease containment by using such tools as a simple checklist to help educate and spread awareness. Introduction Highly infectious diseases such as the one that develops with the novel coronavirus, otherwise known as COVID-19, put additional pressure on the healthcare sphere. The risk of a pandemic increases the patient load of every hospital and clinic, and healthcare personnel (HCP) have to adapt to the new standards of care. At present, the pandemic of COVID-19 is the central problem that concerns the whole world. The urgent need for changes is clear – according to the latest findings, most hospitals and countrywide healthcare systems are not adequately prepared to handle the growing rate of new cases (World Health Organization [WHO], 2020). Thus, this project aims at looking at the existing evidence and investigating guidelines that are based on evidence and should be included in the intervention. Problem Statement The nursing staff is among the first responders that are affected by this outbreak. HCP does not know much about COVID-19, and many of its features and risks are underexplored. The current strategy is symptom treatment and control of spreading, which implies that nurses and other healthcare professionals are under great pressure to prevent the growth of cases. Nonetheless, the lack of awareness about proper crisis responses is evident when analyzing the speed of the infection in the United States and other countries. The focus on nurses’ actions, as a result, is essential to ensuring that the industry is prepared to meet the challenge of COVID-19. Purpose The purpose of this project is the development of an intervention for HCP and medical-surgical nursing staff, in particular, that would help them respond to the pandemic and cap the number of cases in the US. Therefore, it is necessary to consider how nurses should prepare to control the spread of the disease, including measures for prevention and containment. For this purpose, one has to research the latest information about the infection and explore the nursing responses to previous outbreaks similar to the novel coronavirus. Furthermore, the contemporary guidelines from the Centers for Disease Control and Prevention (