Introduction Public health could be seen in terms of being administrative responses towards the need to safeguard and promote health aspects of individuals in its society. Thus, Public health envisages prophylactic health care planning for better application of health resources for people in the United States. While aspects of identification and curing of various kinds of diseases are surely within the agenda of public health, this is not its main task, which, in its broadest scope would embrace, preventive and protective measures of public health. It would not be out of context to mention here that “while individuals are ultimately responsible for their actions, their behavior is heavily influenced by the communities and neighborhoods in which they live. Policies and investments at the local, state, territorial, tribal, and federal levels guide and facilitate actions that all stakeholders must take to improve health, including preparedness for large-scale health incidents.” (National health security strategy of the United States of America, 2009, p.6). Thus, public health as one gleans it to be is not solely the responsibility of Federal, State, or local government, but also needs total support and co-operation of all stakeholders to be accepted and enforced for the public good. Bereft of mass appeal and support, public health schemes and projects would not be able to meet health care challenges that continue to beset them, much less achieve, to a reasonable degree, the aims and objectives of its charter. Different kinds of partnerships that Health Agencies could have The health care scenario in the United States, like trends all over the world, has changed over the last decade, perhaps due to the results occurring in the aftermath of 9/11, anthrax outbreaks, SARS and more recently, in 2009, the H1N1 influenza attacks. These cannot be viewed as isolated health care issues, confined to just one country, or a few States- in truth, these have become global issues that need to be tacked on international levels. Thus, it has dawned, and rightly so on public health administrators of countries that partnership with Cash-rich private sector enterprises could not only be mutually beneficial but could also ensure amelioration of major health care issues through effective, result-oriented partnerships. In keeping with this line of thinking, many global pharmaceutical majors have teamed up with Non-governmental organizations (NGO) to create better health care solutions. The various kinds of partnerships that health agencies could have are:  1. With private sector undertakings for ameliorating health issues and ensuring better health to citizens  2. With academic institutions for new treatment and healing processes  3. Interacting with global aid bodies like World Bank (WB), World Health Organizations (WHO), etc.  4. Interfacing with NGO’s that are engaged in active partnerships with “Private for profit” companies for promoting health care matters. (Reich, 2000, para.1). Analyze two US Public Health partnerships The two United States Public health partnerships are:  1. Partnerships between Glaxo-Wellcome – Task Force for Child Survival & Development – World Health Organization- Rollback Malaria.  2. Collaboration between USG, PEPFAR, Case Foundation and other partners for financing and providing potable water in parts of Saharan Africa. First project Malaria is one of the worst scourges of