Introduction The concept of interpersonal relationship in health practice is something that continues to influence the quality of services and care available to different individuals. This idea forms a strong foundation for all interactions in clinical settings, thereby facilitating the establishment of meaningful patient-practitioner experiences. The relevant terms considered in the research paper below include professional values, ethics and the therapeutic relationship. Professional values encompass all attributes that dictate the practice of caregivers. This term is informed by the major principles of health practice, including patient autonomy, justice and nonmaleficence. Ethics is a notion that focuses on evidence-based aspects and initiatives to protect other people’s rights and liberties while at the same time, promoting the ideas of morality and acceptable personal behaviours. The term “therapeutic relationship” refers to positive interactions between caregivers and patients that promote caring, continuous support, empathy and healing. The existence of such relationships influences the quality of nursing care since practitioners are willing to offer evidence-based medical support. The targeted patients will record positive experiences because clinicians address their health challenges using evidence-based practices. The final result is that positive care outcomes will be recorded. The paper below begins by linking field-specific aspects relating to the therapeutic relationship. The essay goes further to analyse the major issues that support the establishment of therapeutic relationships in nursing environments. The next section addresses the factors that support the maintenance of therapeutic relationships in health settings. The discussion also describes major barriers affecting the implementation of therapeutic relationships. The last section analyses the correlation between professional values and the maintenance of therapeutic nursing relationships. Field-Specific Issues In the nursing literature, numerous ideas have emerged to define the importance of therapeutic interpersonal relationships in care delivery. Scholars and researchers have been focusing on evidence-based aspects that have the potential to maximise patients’ experiences and deliver positive health results. According to Pilgrim, Tomasini and Vassilev (2011), this idea is implemented in different settings, thereby acquiring various names or terms. Some of them include purposeful relationships and nurse-client relationships. What stands out from such concepts is that the health professionals involved embracing appropriate aspects or practices that can improve the experiences of the targeted patients. Walker (2014) indicates that the therapeutic relationship idea is informed by the patient-centred care model. This is true because practitioners focusing on this framework establish desirable partnerships, identify emerging conflicts or challenges, involve other stakeholders and promote superior care delivery procedures. Health professionals put the wishes and expectations of patients first. This initiative makes it easier for them to understand the emotional needs and expectations of the targeted individuals. Price (2017)