One cannot deny that the process of globalization has captured all the regions of the world, including both developed economies and developing economies. Still, the people can comprehend the image of globalization, the terms that have embedded firmly thus creating the increased sensitivity and vulnerability to remote problems. Based on the two dimensions – interdependence and globalism – the processes of globalization encompasses the multilateral agreement and relations leading to the creation of international institutions and changing the work of the regional ones (Keohane and Nye, 2000, pp. 105). However, it is hard to predict how the rise of global relationships can influence the work of the regional institution. Hence, there is the necessity to understand whether it is possible to establish stability and cooperation between those institutions with regard to the contradicting events emerging in the world. The negative effects of globalization and its nonoccurrence with regional politics can be viewed in the example of the United States. Hence, according to Kohut and Wike (2008), the foreign policy of the United States toward the Muslim world has contributed to the rise of instability and terrorism in the country. Being regarded as the trigger of the war on terror, the international public of the East has little confidence in the United States thus expressing its reluctance to establish friendly relations with this nation. Despite the contribution made by the USA to the recession of terrorism and to the prosperity of democracy and globalization, the Muslim people still criticize the Americans for the shortcomings of the globalization process. This unfavorable situation and inappropriate policy on the part of the American government can lead to the decline of its respectability in the world arena. The United States can be an example of how regional policy can affect global policy. In order to achieve the concordance between the goals of multilateral organizations and those of unilateral ones, it is necessary to carefully investigate the strategies established by both. These adaptations can provoke numerous challenges for both types of institutions since the phenomenon of multilateralism involves the consideration of legitimate and reciprocity norms (Keohane, 2006, p 56). This means that global organizations are aimed at constructing the rules and principles that should not contradict the policy of continents and cultures. Therefore, they should take into the deepest consideration cultural, economical, social, and political situations in different countries. In addition to this, international institutions like the World Health Organization or the United Nations Organization should create the measure to improve the social standards and contribute to conflict resolution in different countries. Based on the above, the regional institution should also adapt to the changes proposed by the international organizations. Addressing the foreign policy of the United States once again, the incumbent president, Barrack Obama should apply a less expensive policy towards the Middle East in case the government wants to regain confidence at the international level (Tsai, 2009, p. 46). Drawing a conclusion, the relations between regional and global institution implies a plethora of nuances causing problems and challenges for both. Th