Literature review As it is known, Aldosterone is the main mineralocorticoid hormone of a person’s adrenal glands. Widespread recognition of aldosterone’s role in management of cardiovascular disease has been widely supported by various research evidence based on animal models. There is no doubt that for one to understand the role of aldosterone on the organism of a person, it is important to know the reasons that may cause the increasing of this hormone increasing. So, the regulation of aldosterone is closely connected with the system of renin that is activated during the decreasing of renal blood flow and reducing the income of sodium in the renal tubules. These facts have already been converted into medical practice, as well as large -scale, randomized, placebo -managed tests have verified the advantageous outcomes of mineralocorticoid blockade in individuals with coronary heart failure (Francis and Tang 18). As a result, resurgence in of mineralocorticoid – receptor antagonists in professional medical practice which has motivated the research for a potent as well as certain antagonist without having the sex-related side results of spironolactone. The most common reason for the increasing of the level of aldosterone is a primary aldosteronism. The next reason is a secondary hyperalsosteronism that is reckoned to be the most common type and that presents the increasing of the renin activity that may lead to not pleasant corresponding consequences such as. It may be cause by the congestive heart failure, cirrhosis of a liver, etc. Aldosterone induces a wide variety of procedures which steer to progressing focus on body organ destruction in the heart, vasculature, as well as kidneys. Essentially, Eplerenone is a form of picky mineralocorticoid receptor antagonist which has lowered progesterone-like as well as antiandrogenic adverse reactions whenever likened to spironolactone. According to (Francis and Tang 18), Eplerenone has proved to efficiently lower morbidity as well as mortality among patients with suffering from left ventricular dysfunction or heart failure resulting from an acute myocardial infarction. Eplerenone furthermore efficiently decreases blood pressure whenever likened to agents like losartan as well as enalapril (Cody 588). It is typically perfectly tolerated, despite the fact that hyperkalaemia with this agent is an issue of considerable concern. Individuals with lowered renal function as well as diabetes, in addition to those on some other medications which elevate serum potassium ranges, are at elevated danger. The spot of eplerenone in therapies will in substantial part end up being established by its price and also the ability of future studies to demonstrate a medical advantage of the agent over spironolactone. According to (Cody 588) aldosterone has in the past been widely cited as an essential material in pathogenesis of heart disorder. Raised aldosterone amount is largely recorded among hypertension and heart failure patients, resulting into usage of aldosterone antagonists with regard to therapy of these types of circumstances. There is increasing proof that aldosterone takes on an essential function in the growth of end-organ d