Introduction Over the years, the globe has continued to experience augmented levels of terrorism and upsurge of revolutions, especially in North America and the Middle East. With such developments, the need for transformation and strategy changes are critical in ensuring cooperation and prevention of extremism risks. In reality, the increase in worldwide terrorism and revolts has forced the North Atlantic Treaty Organization (NATO) to embrace novel expertise in conducting its activities. Additionally, the organization is binding its military capabilities with innovative policies along with tactics to structure its training programs and philosophical approach to military interventions. Moreover, NATO’s current military operations employ capability-oriented approaches as opposed to previously applied force-oriented regarding military planning. Further, time-based capabilities, shared awareness and coordination of all military services have formed the core of NATO’s strategies in dealing with irregular terrorizations 1 . The other approach being utilized by the organization entails an emphasis on smart weapons, space-based systems as well as the C4I. Principally, the abilities are invaluable in coordinating the competencies of the force towards offering international security assistance in many countries across the globe, including Afghanistan and the Middle East. Generally, NATO’s novel transformations towards network-centric warfare have been significant in preventing international terrorism. Besides, changes in military tactics increase the organization’s capabilities in enhancing peace. In fact, the transformations in the Alliance’s strategies offer tactical prospects in terms of enhanced interoperability. In addition, the strategic transformations increase the organization’s capabilities significant in the elimination of extremism threats. In this regard, the paper assesses the strategic transformations of NATO in relation to the International Security Assistance Force (ISAF) in Afghanistan and the Greater Middle East. International Security Assistance Force in Afghanistan and the Greater Middle East Undeniably, radicalism and the spread of weapons of mass obliteration are issues of great concern. Just like other nations, Afghanistan and several nations within the Middle East continue to experience unprecedented levels of extremism. In this regard, NATO offers international security assistance to the Government of the Islamic Republic of Afghanistan and other states in the Middle East to eradicate the upsurge of radicalism. Additionally, NATO provides military backup to the progression competencies in Afghanistan as well as the aptitudes of the Afghan National Security Forces (ANSF). Further, through the resolutions of the United Nations Security Council (UNSC), ISAF creates a safe and steady atmosphere in Afghanistan by steering safety and stability actions across the nation. ISAF also has the role of inspiring the reconstruction and development efforts in Afghanistan through donating practical support to the nation. Besides, consolidation of institutions based on the rule of law as well as good governance also forms the core of ISAF’s mandate. In this regard,