Background Cancer is a critical public health concern relating to mortality and morbidity globally. Diverse cancer type patients agonize from lingering comorbid circumstances that are a leading clinical problem for cancer handling and managing. Socioeconomic status, physical activity levels, age, and health burden magnitude dictate individuals’ chances of developing comorbid conditions that lead to cancer growth. Holistically, engaging in physical activities remains the ultimate option for combating different ill-health diseases. Aim This study’s primary goal was to investigate the comorbid conditions distribution in Australia and the associated predictors among the cancer patients between the 2007-2017 period. Design The study embraced a longitudinal design using information in the Domestic, Income, and Labor Subtleties in Commonwealth of Australian investigation. The longitudinal consequence was effectively apprehended through the fixed-effect adverse binominal reversion model, predicting the budding issues that enhanced the occurrence of chronic comorbid conditions. Method The data collection method that was used is interviewing, whereby the participants were interviewed subsequently over time. Results Sixty-one percent of the cancer victims incurred one or more enduring diseases over a specific period. Moreover, 21 percent of the participants incurred more than three chronic conditions. Patients living in low socioeconomic status conditions, do not engage in physical activities, burdened by health, and the elderly are at significant risk of developing comorbid conditions. Conclusion Overall, many cancer patients experience a significant health load of long-lasting comorbid situations. The diverse scopes of the cancer fighters critically affect their cancer burden trajectory. Therefore, it is prudent for healthcare professionals who manage the exceptional needs that encounter this populace to champion for evidence-based disease prevention interventions. Introduction Cancer is a leading and significant healthiness apprehension regarding mortality and morbidity in Australia and globally. Nearly 9.6 million persons die from cancer yearly. Arguably, Australia is not left behind, considering that in 100,000 people, 483 new case cases are discovered as per the year 2019. On average, more than 136 people die from cancer illness in the whole Australia yearly (Australian Institute of Health and Welfare, 2019). Cancer equally contributes to eighteen percent of Australia’s total disease burden, followed by cardiovascular diseases at fourteen percent, musculoskeletal conditions at thirteen percent, and mental illnesses at twelve percent (Australian Institute of Health and Welfare, 2015). Also, there are roughly one million cancer survivors in the country. Notably, numerous forms of cancer-related victims are ailing and grieve from comorbid circumstances that bring a key scientific test for cancer dealing and running. Therefore, it is worth noting that cancer is one of the biggest health challenges that are facing the people of Australia. The five-year cancers fighters united have tremendously upgraded in Australia, beginning from 48 to 69 percent, comparing between the 2001 and the 2015 statistics. Hi