Introduction The healthcare challenges associated with adolescents seeking care for depression, anxiety, and suicidal throughs remain unaddressed despite their increasing severity. It is problematic for adolescents to deal with negative emotions on their own because, during that period of their life, they struggle with developing and preserving emotional and social habits, which are essential to their well-being. When left unaddressed, young individuals’ mental health issues exacerbate and contribute to the increased level of stress through adolescence and adulthood, as well as severe implications such as depression and suicide (Malakouti et al., 2015). Therefore, the psychological challenges that individuals face when they are younger are essential to address in order to reduce the occurrence of adverse consequences such as suicide. The aim of the current assessment is to evaluate the available evidence-based practice targeted at addressing suicide rates and improving the strategies intended to prevent the occurrence of adolescent depression and suicide. In the course of the assessment, a position statement will be developed in the evidence-based PICO format concerning the recommended intervention to address symptoms of depression and suicidal thoughts among adolescents. POI Significance The significance of establishing evidence-based practice procedures is associated with the possibility of addressing the mental health needs of the target population. Some changes in practice would be put in places, such as maintaining regular contact with patients and their parents. The promotion of relevant health information for ongoing patient education, as well as the referral to mental health specialists and suicide prevention programs if needed (Malakouti et al., 2015). The implementation of the change process is expected to bring improved outcome measures, which would illustrate the influence of a healthcare intervention on patients’ health status (Agency for Healthcare Research and Quality, 2015). Specifically, it is expected to see a reduced percentage of adolescents ending their lives by suicide, a dropping rate of individuals of the age group having thoughts about suicide, as well as a lowering occurrence of depression and anxiety in the adolescent population group. PICO The PICO or clinical question formulated in regards to the identified healthcare issue is the following: in the population (P) of adolescents aged between 10 and 19 presenting to emergency departments or their NPs, what is the impact of an intervention (I) implying routine depression and suicidal evaluations, in comparison (C) to not implementing intervention and preserving the standard procedures, on improving the mental health of adolescents (O) with depression and suicidal throughs and ideations. Thus, the target population involved in the PICO question is the group of adolescents aged 10 to 19 years old who present to emergency departments or seek care through their PCPs and NPs with symptoms of behavioral depression and suicidal attempts or having thoughts about killing themselves. The intervention suggested for implementation is concerned with conducting regular evaluations of the target population’s depression and suicidal thoughts during their visits to primary care professionals as opposed to evaluating patient