Introduction In the 1960s after the Appalachian Regional Commission was formed, there was an increase in the efforts put to fight known causes of poor health in the Appalachian region which included limited education, geographic isolation and low income. The release of the national maps by the National Center for Health Statistics (NCHS) displayed the mortality rates within the Appalachia region bringing into light the health status of Appalachia’s (Behringer, B and Friedell, G. H. 2006). Culture and mode of life Appalachians put into consideration faith in God and medical care benefits when seeking for cure. Faith has not been found as a barrier when seeking health care and for people with cancer its used as a consoling factor. Recent surveys have shown higher rates of cancer especially cervical cancer, premature mortality and heart disease in the Appalachian population (Huttlinger, K., 2003). Studies in the urban Appalachia region have found out that 50% of patients in the primary care are associated with production, use or sales of tobacco. The region has a history of inadequate health professionals which coupled to the referral centers long distances from rural centers has limited availability of patient care. Environmental influence on the Appalachians health can not be underestimated. Of importance include unclean air; toxic waste; occupational exposures, farm effluents, factories and mines that contaminate water. Private, proud and desiring to “take care of their own” are some of the Appalachian characteristics. Health professionals thus face a great challenge of understanding the personal characteristics of Appalachians and utilizing them to create a two-way communication on cancer preventive measures. Poor communication between the health experts and their patients results into a barrier for the patients to pursue screening, diagnoses as well as treatment. High rates of unemployment hamper individual’s ability to cater for health care bills either directly or from job-related benefits. Mortality rates have been shown to differ with the eastern Kentuckians dieing younger as compared to the central and western Kentuckains. Infant deaths in this region have been on the higher side as compared to the state average (Obermiller, P. J and Brown, M. K. 2002). Migration factor America has constantly experienced Appalachian mountain migration since the year 1820. Earlier migrations were from the west to the rural areas while the later ones after the Civil War had an urban focus. During the Great Appalachian Migration in the twentieth century (1940-1960), migrants settled in the industrialized Midwest and Northeast region. The migrations later switched on to the South as well as the West regions of metropolitan area. Cities surrounding the Appalachian region in 1970s became the principal host of the Appalachian migrants. Today Cincinnati city and its environs hosts a large population of Appalachian migrants as well as their descendants and it continues to receive a significant number of new Applachian migrants (Obermiller, P. J and Brown, M. K. 2002). Appalachian Health Issues Early studies in the 1960s to 1980s noted that health services were mostly got on a crisis basis. These early studies noted the importance of folk m