Introduction On April 8th, Amina J. Mohammed, the United Nations Deputy Secretary-General, said: “We are facing a humanitarian crisis unlike any we have experienced and our social fabric and cohesion is under stress” (Alessi). This statement reveals that the coronavirus disease of the 2019 (COVID-19) pandemic is a major challenge that will affect all aspects of human life. If people fail to implement evidence-based strategies to deal with it, chances are high that more lives will be lost. COVID-19 remains a mysterious health condition that most of its facts still remain unknown. The healthcare sector has been unable to meet the demands of the population by protecting them against any unknown disease or providing adequate protective measures. These attributes of COVID-19 make that similar or equal to Goliath. Malcolm Gladwell is a successful Canadian writer, public speaker, and journalist whose works have guided many people to achieve their goals in life. He has succeeded in using most of his publications to combine academic work and social change to influence human thoughts and approaches to the issues they face. In the book David and Goliath: Underdogs, Misfits, and the Art of Battling Giants , Gladwell offers superior insights that human beings need to take seriously to succeed in both the business world and their personal undertakings. He identifies the David vs. Goliath perspective as a powerful idea whereby the weapon one has does not matter the most. He goes further to describe David as a resolute fighter who focused on the power of speed, precision, and agility. Using Gladwell’s Goliath vs. David perspective, American policymakers, medical professionals, all other key stakeholders need to consider additional ways to control the spread of COVID-19, reduce deaths by providing superior medical services, and move swiftly to find a cure or a vaccine. Application of Gladwell’s Ideas to COVID-19 The concept of Goliath vs. David is a powerful model that different institutions, citizens, and professionals need to pursue to overcome the rate at which COVID-19 is spreading in different parts of the United States. COVID-19 is a new infectious disease that is affecting the lives and experiences of many people while at the same time exposing the weaknesses and unpreparedness of the American healthcare sector. The causal virus for this condition was discovered in 2019 after Wuhan, China, recorded the first cases of COVID-19 in November the same year (MacKenzie, p. 12). With the disease being transmitted from person A to B rapidly, this condition spread to different parts of the world within less than two months. It has continued to affect the lives and economic outcomes of many citizens in the United States. Around 55,000 deaths associated with COVID-19 have been recorded in this country (Bellware et al.). All organizations, politicians, and individuals can pursue the Goliath vs. David strategy to overcome the current spread of COVID-19. Such stakeholders need to combine their strengths with emerging ideas in order to deal with this challenge and eventually succeed in their key areas. All agencies involved in this pandemic need to consider such Gladwell’s model and eventually collaborate to identify evidence-based strategies to re