The social stigma problem exists nearly in all parts of the world, including North America. According to Travaglini et al. (2018), stigma acts as a significant barrier to the treatment of sexually transmitted diseases (STDs) or sexually transmitted infections (STIs) in North America. The most common STDs in the region are chlamydia, human papillomavirus (HPV), gonorrhea, and human immunodeficiency virus (HIV). For instance, Canada reported a 49.3% increase in chlamydia infection from 2005 to 2014, with the highest cases recorded among males (Logie et al., 2018). Similarly, the United States, among other North American sovereign nations and dependencies, records considerable numbers of STDs annually. Sadly, the existence of different races such as African Americans, Hispanic Americans, and Asians, among others, has led to misconceived notions about individuals with STIs, making it hard for them to accept their conditions. Fundamentally, the social stigma in the North American countries and dependent territories have contributed to distress among the people with STDs and increased the prevalence of preventable STDs such as HPV due to improper medications. First, the North American countries report high numbers of STDs annually. According to Reif et al. (2019), about 19 million new cases of STIs occur yearly in the United States, costing approximately $10-17 billion dollars. Indeed, the prevalence of STDs continues to increase among young adults and adolescents in the USA. Similarly, Mexico also experiences an escalation of various STIs, including HIV/AIDs, mainly due to the augmented sex workers’ trade. A study by Patterson et al. (2019) revealed that female sex workers in 13 cities in Mexico had various STDs such as HIV, gonorrhea, syphilis, and chlamydia, with the latter having the highest percentage of 15.3. The findings also indicated that the prevalence rate varied across the Mexican municipalities based on the distribution of female sex workers. The situation is relatively the same in Canada and other dependent territories. These figures demonstrate the significance of the STIs problem in North America and the considerable harm social stigma could cause to the population. Consequently, there is a dire need to embrace people with STDs in the region to inspire them to access the appropriate medications to control the prevalence rate. Some primary factors cause social stigma in the North American countries and dependent territories. For instance, a study by Darlington and Hutson (2017) conducted in the major states of the United States demonstrated that people are often judgmental about sex. Such misconceived notions lead to unnecessary condemnation of individuals diagnosed with STIs. Indeed, the results highlighted that STD stigma is the worst shame experienced by North American residents. Individuals often react negatively to news of a person diagnosed with an STI. They stereotype such an individual as slutty or dirty and someone who engages in sex unnecessarily. Unfortunately, this perception is always hurting because many individuals get infected in different circumstances, which may be beyond their control, such as rape. As a result, people living with an STD feel insecure and fear losing their family members. Some individuals also become domestic violence victims due to daily scornful