The use of somatostatin analog in gastroenteropancreatic tumors other than carcinoid.


The patient was given methimazole instead of propylthiouracil but, 10 weeks later, agranulocytosis again occurred.


Ethambutol is an antimicrobial agent used frequently to treat tuberculosis.


Dofetilide has been shown to be effective and safe in maintaining sinus rhythm in patients with persistent atrial fibrillation and congestive heart failure.


IgG1 and IgG4 were the predominant IgG subclasses in the glomerular deposits.


Treatment with octreotide brought about the remission of diarrhea in this patient.


It was characterized by hyperandrogenism and polycystic ovaries in all cases, and it was associated with weight gain and menstrual disorders in 2 of the 3 women.


Noncirrhotic portal hypertension: another cause of liver disease in HIV patients.


Since this amount of FAB was insufficient to bind all DGTX present in the serum, cardiac DGTX toxicity (total AV-block) persisted.


These results indicate that the hyponatremia in this case was due to SIADH and that SIADH was caused by an increased release of vasopressin probably because of the antiviral drug (acyclovir) or infection of varicella zoster virus (VZV) in a single dermatome.


CONTEXT: Radiation recall has been described in the context of gemcitabine chemotherapy.


Antiarrhythmic agents can cause pneumonitis.


Flavimonas oryzihabitans has been isolated from a wide range of body sites, and the portals of entry are major wounds or implanted foreign materials.


Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist.


Since 1955, a number of phenothiazines had been tried, also with little improvement.


In humans, 80-90% of an administered dose of 5-fluorouracil (5-FU) is degraded by dihydropyrimidine dehydrogenase (DPD; EC 1.3.1.2), the initial rate-limiting enzyme in pyrimidine catabolism.


Diagnosis of TTS is one of exclusion as it can mimic many other conditions, and should be considered in patients with unilateral painless ulcerations with a history of trigeminal nerve damage.


High-resolution computed tomography scan findings were consistent with ILD, which was sufficient to diagnose as erlotinib-induced ILD.


Following the institution of intravenous therapy with acyclovir, the patient developed fever, hemoptysis, and a pleural friction rub.


NEH occurs most frequently in patients receiving chemotherapy for haematologic malignancies.


This case illustrates an association between CMV and TMA in a transplant patient with resolution of the latter after treatment of the CMV.


Olanzapine is a relatively new antipsychotic drug used in the United States for the treatment of schizophrenia.


Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma.


BK virus-associated nephropathy (BKVN) has become recognized as an important cause of allograft dysfunction in renal transplant recipients and despite reduction in immunosuppression, 30-40% of recipients ultimately progress to allograft loss.


The mechanisms by which these agents interact to produce prolonged hypoglycemia are complex and probably multifactorial.


Local ILP toxicity appeared with extensive edema and common peroneal neurologic impairment including paresis that remained severe 10 months later.


The patient sustained a severe septic episode, was treated with antibiotics and GM-CSF, and recovered the 14(th) day after ticlopidine withdrawal.


He developed optic atrophy and steroid complications, including cushingnoid features and growth maturation delay.


In all 5 patients the need for oral corticosteroid therapy was substantially decreased or eliminated, thus decreasing potential corticosteroid-induced morbidity.


Ganciclovir and standard high-dose immunoglobulins were administered to the patient with resolution of the pneumonia.


This article describes a patient with suspected ciprofloxacin-induced interstitial nephritis.


The prevalence of pregnancy loss in women with FMF is considered to be high.


The patient was well on routine follow-up at the outpatient clinic, with no progression of lymphoma or interstitial pneumonitis.


A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion.


Olanzapine is a newly developed atypical neuroleptic with a marked affinity to the 5-HT2, D2 and D4 dopamine receptors.


An association between gadolinium-containing contrast and the development of nephrogenic systemic fibrosis (NSF) has been increasingly recognized.


Treatment for up to 2 years with SMS controlled symptoms, suppressed serum gastrin, and suppressed acid secretion.


A repeat sodium was 124 mmol/L, and she was admitted.


Other clinical symptoms of sarcoidosis resemble side-effects of interferon.


De novo absence status of late onset following withdrawal of lorazepam: a case report.


Lupus-like syndrome caused by 5-aminosalicylic acid in patients with inflammatory bowel disease.


The aim of this study is to assess the impact of oseltamivir on the control of INFVA infection in BMT recipients.


The optimal length of therapy is not known, though there are indications that treatment can be discontinued shortly after seizure control.


Thrombolysis with recombinant tissue plasminogen activator is the only established treatment for acute ischemic stroke.


Anaphylactic/anaphylactoid reactions to methotrexate are rare.


Changes in serotonergic function may play a more widespread role in the pathophysiology of seizure disorders than hitherto thought.


Alzheimer type II glias and abnormal glias closely resembling Alzheimer type I glia were numerous in the affected white matter.


Cutaneous adverse reactions to 8-methoxypsoralen (8-MOP) appear to be rare and may be difficult to distinguish from phototoxicity or UV-induced polymorphic light eruption.


Patients were treated with CPA at the doses of 200-300 mg/d for malignant prostate disease for 3-12 mo prior to the acute manifestation of the hepatic disease.


Introduction of the balloon into the left atrium resulted in thrombotic occlusion of the mitral valve.


Severe erythroderma as a complication of continuous epoprostenol therapy.


A within-series phase change design (ABABC) was used to evaluate the effect of video distraction and relaxation in the treatment of a 29-year-old male with anticipatory vomiting associated with cancer chemotherapy.


Six patients were identified.


The relationship between BP and chronic renal failure and/or hemodialysis is not clear, but we believe that immune disarrangement due to chronic renal failure and/or hemodialysis may have influenced the pathogenesis of BP in our case.


MAIN RESULTS: Followup echocardiogram on day 10 showed complete resolution of the thrombus.


Dapsone-induced erythroderma with Beau's lines.


Neutropenia-wise and pound-foolish: safe and effective chemotherapy in massively obese patients.


CONCLUSIONS: Neurologists have a vast armamentarium to treat both motor and nonmotor manifestations of PD.


More than 50 cases of tuberculous peritonitis complicating CAPD that have been reported in the English-language literature since the initial case was reported in 1980 are reviewed.


In rare cases, EM presents continuous or persistent relapses, and has been related to an Epstein-Barr virus infection.


One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy.


Intrasellar and parasellar tumors made manifest by hormonal influences of pregnancy may become more common as treatment of infertility becomes more refined and successful.


We report the case of a patient with increased cerebral cortical excitability following intoxication with flupirtine, a centrally acting analgesic and antispastic drug.


CONCLUSIONS: Severe neuroleptic sensitivity and associated deficits of cognitive speed occurred in response to a dopaminergic antagonist agent; both responded readily to withdrawal of the offending agent.


A case of timolol-associated heart failure in a 73-year old white man is reported.


A 57-year-old male developed an adenocarcinoma lung cancer in November 2003.


The patient developed a broad-QRS-tachycardia and severe hypotension.


We report 3 patients who developed cutaneous vasculitis which is a rare and serious side-effect during antithyroid drug therapy.


Desensitization with methotrexate was successful and allowed the patient to complete 12 additional courses of chemotherapy.


In the second case, five cardiac arrests due to ventricular tachycardia and fibrillation occurred during several hours after beginning a trial of bretylium maintenance therapy for complex ventricular ectopy.


Long-term use of topical tacrolimus (FK506) in high-risk penetrating keratoplasty.


Azithromycin is considered unlikely to interact with warfarin.


Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.


A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented.


This progressed to tracheal compression with stridor after he had taken some aspirin for relief of the neck pain.


In this report and other reports describing successful resuscitation, the total dose of sodium bicarbonate is conspicuously higher than in reports describing extracorporeal interventions.


Reduction of tumor burden and stabilization of disease by systemic therapy with anti-CD20 antibody (rituximab) in patients with primary cutaneous B-cell lymphoma.


Erythroid engraftment was successful with primary steroid treatment.


Macrolide antibiotics cause ototoxicity, which occurs most frequently when high serum concentrations are achieved.


He developed Epstein-Barr virus-associated malignant lymphoma at 10 years and thyroid papillary carcinoma at 20 years of age.


Amyloid goiter in a child with familial Mediterranean fever.


Rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent.


The authors present two patients in whom it was necessary to substitute the Erwinia enzyme for the E. coli enzyme because of the occurrence of severe allergic reactions to the E. coli enzyme.


Infections seem uncommon.


One and a half hours after receiving 110 mg suxamethonium for oesophagoscopy, the patient was still apnoeic with no response to ulnar nerve stimulation.


Children receiving zonisamide should be monitored for oligohidrosis and the development of neurological symptoms associated with an elevation of body temperature.


In addition, cultures of specimens obtained at autopsy did not reveal a cause for the heart failure.


Ocular symptoms began between 3 and 6 months after transplantation.


Treatment of a patient with severe digitoxin intoxication by Fab fragments of anti-digitalis antibodies.


He was transferred to our hospital when he was discovered to have acute renal failure with hyponatremia (118 mEq/L) and severe rhabdomyolysis (creatine phosphokinase, 227,200 IU/L).


We aimed to report a case with rhabdomyolysis related to hyponatremia and/or its correction.


DISCUSSION: Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure Several drugs have been associated with rhabdomyolysis, including lovastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor.


This case highlights the potential of ritonavir interactions even with local injections of a corticosteroid.


Hence, hyperthyroidism induced by IFN-alpha could correspond to the first phase of silent thyroiditis, to Graves' disease or to the succession of both.


A 65-year-old man on warfarin therapy with a sudden spontaneous onset of sub-conjunctival haematoma associated with bloody tears was assessed in the clinic following a referral from an optometrist.


However, she was unable to follow commands and she expressed rigidity of extremities, mild tachycardia, and stupor.


When enzyme levels in the proband and relatives were compared with that in controls, an autosomal recessive pattern of inheritance was demonstrated.


A p value < 0.05 was considered statistically significant.


The patient's previous rash and the temporal relation of this event and the ingestion of phenolphthalein, as well as the similarity of this case to other reports, point to phenolphthalein as the cause of TEN in this patient.


At the third session of TACE, the right hepatic artery was found to be thrombosed; however, angiography also demonstrated collateral feeder vessels (arising from the pancreaticoduodenal artery) which were used for treatment.


Gastric tumor, endometrial carcinoma and cervical adenocarcinoma in situ were detected after treatment with tamoxifen for breast cancer.


Electrophysiologic evaluation demonstrated failure to terminate ventricular tachycardia with maximal energy shocks, but consistent termination by low energy discharges.


Ifosfamide-induced nonconvulsive status epilepticus.


Diagnosis of attention-deficit/hyperactivity disorder by family physicians and pediatricians was most commonly based on brief behavioral descriptions by parents and, infrequently, by use of rating scales.


Neutropenic colitis has been thought to be a serious gastrointestinal complication associated with chemotherapy for hematological malignancy.


A 26-year-old man developed painless inferior subepithelial infiltrates away from the site of ablation in both eyes after excimer laser photorefractive keratectomy (PRK) for myopia.


We report two patients with acquired fistulas between the internal mammary and pulmonary arteries after coronary bypass surgery.


Immuno-chemo-radiotherapy (interferon, ranimustine, and radiation), second-line chemotherapy (carboplatin and etoposide, 7 cycles) and third-line chemotherapy (ifosfamide, carboplatin, and etoposide) was given to treat progressive disease.


The patient who had been treated the longest and had received the highest total dose also had the highest SCE count.


Is pseudo-Cushing's syndrome in a critically ill patient "pseudo"? Hypothesis and supportive case report.


The plasma concentrations of procainamide and N-acetyl procainamide were at subtherapeutic levels.


Three patients with niacin-induced visual symptoms had cystoid maculopathy without leakage on fluorescein angiography, and a fourth patient with no fundus abnormality experienced cessation of visual symptoms upon discontinuation of niacin.


The median survival was 22.1 months in all and 17.1 months in six patients with PVTT.


DISCUSSION: To our knowledge, this is the first case report illustrating neuralgic amyotrophy triggered by exposure to the antibiotics vancomycin, tobramycin, and piperacillin/tazobactam.


RESULTS: The response rate was 84.6%, with complete response in one patient and partial response (PR) in 10 patients.


Radiation therapy decreased the size of the mass, but five months later partial small bowel obstruction occurred because of recurrent lymphomatous infiltration.


3. Thus, the decreased plasma cortisol level during alprazolam treatment of panic disorder was suggested to be caused not by symptom alleviation due to alprazolam but by alprazolam administration itself.


Two patients who were receiving Tolazoline by infusion developed duodenal ulceration and subsequent intestinal perforation.


Sequential CT studies were performed in 24 patients with infantile spasms, before, during and after ACTH therapy, in order to analyze the relationship between the dose of ACTH and changes in CT scan findings.


Acetazolamide may have accelerated the development of osteomalacia by several mechanisms, including increased renal calcium excretion.


An objective causality assessment by use of the Naranjo probability scale revealed that NCSE due to ifosfamide was probable.


Nurses can be instrumental in minimizing the impact of these conditions by monitoring the longitudinal trends in Hb levels, proactively assessing patients for inflammatory or infectious conditions, and intervening to resolve causative conditions and minimize the impact on anemia.


Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.


OBJECTIVE: To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction.


Hepatotoxicity related to itraconazole: report of three cases.


We will also discuss the unusual nature of this type of burn and the course of phototoxic lesions and their differences from a typical sunburn.


We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.


Diagnosis was based on a history of repeated exposure to sulfonamides, skin biopsy findingd, and clinical recovery on cessation of sulfonamide therapy.


Hyperperfusion syndrome is a well-documented clinical complication after endarterectomy and carotid stenting.


Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.


There was minimum toxicity reported for either of the arms and no treatment related deaths.


A prompt and accurate diagnosis is crucial.


The patient was a borderline candidate for mechanical ventilation for 3 weeks.


In five of these cases the episode began after an unusually large dose, in three after a therapeutic one with a latency of about 24 hours.


We describe the case of acute hepatitis induced by gliclazide, a second generation sulfonylurea.


Systemic absorption of oral vancomycin in a peripheral blood stem cell transplant patient with severe graft-versus-host disease of the gastrointestinal tract.


Renal function improved rapidly after withdrawal of the drug therapy.


An analysis of our patients, together with literature review of similar cases, suggests that the duration of chemotherapy may have been the most important factor in the leukemogenesis.


Increased ocular pressure in two patients with narrow angle glaucoma treated with venlafaxine.


We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy in patients with recurrent ovarian cancer receiving multiple platinum-based chemotherapy.


Mequitazine is a phenothiazine derivative antihistamine.


Complete remission of the nephrosis occurred after discontinuation of hydroxychloroquine therapy.


Anorexia in a 14-year-old girl: why won't she eat?


The ACE inhibitors can cause various skin side effects; however, it rarely causes cutaneous vasculitis.


The thigh and buttock muscles were "wooden-hard" on palpation.


These observations indicate that submassive hepatic necrosis may result from treatment with propylthiouracil and are consistent with the notion that sensitization mechanisms may be responsible for the hepatic injury induced by this drug.


CONCLUSIONS: Intrathecal baclofen can impair sexual function and ejaculation in some patients.


We describe a woman who received polyacrylamide gel injections for cosmetic reasons and developed a severe granulomatous inflammation paranasally.


A case of contact dermatitis due to sodium bisulfite in an ophthalmic solution.


To discuss the possible mechanisms of action and highlight the potential detrimental effects of dipivefrin on palpebral conjunctiva.


Psychoendocrine sequelae of chronic testosterone deficiency.


We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).


Bleomycin and cyclophosphamide toxicity simulating metastatic nodules to the lungs in childhood cancer.


Severe lidocaine intoxication by cutaneous absorption.


Central serous chorioretinopathy associated with inhaled or intranasal corticosteroids.


Immunosuppression with ciclosporin can be an effective and well-tolerated treatment for steroid-responsive sudden SNHL.


Anticoagulation was started, the OCP was discontinued, and a discussion occurred regarding the treatment options for her menorrhagia following her recent diagnosis.


None of the patients had a previous history of glaucoma, ocular hypertension or IOP asymmetry and the IOP was as high as 30, 34, 46, and 50 mmHg in the four patients.


Cerebral dural sinus thrombosis is an unusual syndrome in which a patient presents with a severe headache that may be associated with diverse neurologic and physical findings.


Here, we describe a case of Vogt-Koyanagi-Harada disease occurring 4 months after the start of interferon alpha treatment, probably induced by the immunomodulatory effects of interferon.


We report a case of anterior uveitis after small-incision cataract surgery due to an intraocular ointment base.


Autopsies of four cases of toxic leukoencephalopathy were performed following standard protocols.


In such patients the drug is withdrawn and replaced by another medication.


ARDS is rarely associated with rituximab infusion for lympho-proliferative disorders, but it should be considered by those administering rituximab, especially when a patient develops severe pulmonary symptoms soon after infusion.


The patient's metastatic disease remained stable for the next 2 years.


Test and teach.


We report on a 37-year-old female who complained of moderate hair loss during paroxetine treatment.


CONCLUSION-It is possible to prevent GH from PHT treatment by intensive dental care, correct mouth hygiene and by change of treatment of carbamazepine.


Plasma drug concentrations were largely kept within the therapeutic range but wide variability was observed on oral therapy.


A 29-year-old woman with a long history of primary nocturnal enuresis began treatment with intranasal desmopressin.


The tube was removed by external traction, without any abdominal incision, and a different site was used for the insertion of a new percutaneous endoscopic gastrostomy tube.


A 14-year-old girl presented with severe haemorrhagic diathesis.


Adults with immunosuppression should receive prompt systemic treatment with acyclovir.


The biochemistry of paracetamol hepatotoxicity is outlined and the increased susceptibility of alcoholic patients to the hepatotoxic effects of paracetamol is remarked upon.


Five of 610 adults developed chickenpox between 35 days and 9.2 years after renal transplantation, and only one patient survived.


In conclusion, even if in our case no surgical treatment was used and although spontaneous resorption has been described for some materials, early surgical exploration with removal of the material and decompression of the IAN is suggested, irrespective of the material used, because the severity of nerve damage can increase with the duration of the injury.


Recently, atypical antipsychotics have been more widely used in the treatment of behavioral and psychological symptoms with dementia (BPSD) than conventional neuroleptics because of a reduced tendency for movement disorders and psychomotor retardation.


Two courses of tinidazole (the second in combination with percutaneous aspiration of the abscess) were required to achieve cure.


The patient was diagnosed with carbamazepine toxicity related to the introduction of ritonavir.


RESULTS: Four pediatric patients (2 males and 2 females) with mean age of 14.5 years (range 11-18 years) were studied.


All patients tolerated the treatment well with no residual effects from the electric pulses.


UFT, a combination of uracil and tegafur, is a second-generation anticancer agent.


The beneficial effect of the long-acting analogue of somatostatin SMS 201-995 in the treatment of acromegaly is described in three cases, and current published experience is reviewed.


Although nondiphtherial corynebacteria are ubiquitous in nature and commonly colonize the skin and mucous membranes of humans, they rarely account for clinical infection.


Proponents of the use of fluoroscopy cite studies that report up to 35% rates of inaccurate placement of epidural needles without the aid of fluoroscopic imaging.


She developed gastrointestinal, central nervous system, cardiovascular and haematological disturbances.


Our report suggested that CBDCA hypersensitivity was correlated with the total dose of previously administered platinum agents and that CBDCA should be excluded in patients who have received multiple platinum-based chemotherapy, even in platinum-sensitive cases, because CBDCA hypersensitivity can occur even with low-dose CBDCA administration.


It is suggested that hasty correction of thyrotoxicosis should be avoided in susceptible patients, unless the thyrotoxic conditions are critical.


OBJECTIVES: To describe clinical and pathologic findings in patients noted to develop lower gastrointestinal symptoms when exposed to rofecoxib.


He also showed a large tongue with an anterior open bite.


A complete ocular examination, fluorescein angiography, carotid artery Doppler sonography and brain magnetic resonance imaging were performed.


CP is classified as a pregnancy risk factor D drug and is teratogenic in animals, but population studies have not conclusively demonstrated teratogenicity in humans.


An alternative preparation, methylprednisolone, was used to successfully treat her underlying condition.


High-flux haemodialysis treatment as treatment for carbamazepine intoxication.


An allergic reaction to a drug's additive material should be considered as a rare cause of drug-induced acute eosinophilic pneumonia.


Persistent idiopathic facial pain following dental implant placement: a case report.


RESULTS: Routine histology confirmed the clinical diagnosis of oral lichen planus-like c-GVHD.


Subsequently, when ferrous sulfate was discontinued, the patient became hyperthyroid while taking the higher dose of thyroid hormone preparation.


The dialyzer circuit did not clot during the argatroban infusion and did not apparently influence dose-related aPTT measurements.


The third patient developed liver and marrow toxicity on day 3 and died on day 9.


We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia.


Baseline measurements of anterior chamber depth and lens thickness were obtained.


Despite chemotherapy, the patient died 2 months after the diagnosis.


CYP2D6 gene deletion allele in patients with neuroleptic malignant syndrome: preliminary report.


The symptoms were attributed to hepatitis B vaccination.


Posterior reversible encephalopathy syndrome associated with methotrexate neurotoxicity: conventional magnetic resonance and diffusion-weighted imaging findings.


The underlying pathogenesis is probably multifactorial.


PAIN Control: IV opioid range orders for acute pain management.


This is a report concerning a patient in whom a continuous infusion of dexmedetomidine was safely used for a week to help in averting frank withdrawal symptoms from an opioid and benzodiazepines.


Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.


In two dogs the lesions resolved after 7.5-8.5 months of immune-suppressive treatment.


Osteonecrosis is not well documented as a predisposing factor of septic arthritis despite such a relationship having obvious clinical significance.


The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.


CONCLUSION: The choice of anticoagulant and antiplatelet agents, dose, and timing of administration can affect outcomes in patients with NSTE ACS.


In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.


RESULTS: A 60-year-old woman with chronic active viral C hepatitis (HCV genotype = 3a) started IFN-alpha therapy in November '96.


These findings are compatible with PVOD.


Severe lactic acidosis related to acute thiamine deficiency.


Rhino-orbital zygomycosis secondary to Rhizopus oryzae in a renal transplant recipient successfully treated with liposomal amphotericin B.


Histopathology of maculae showed extensive collections of melanophages in the upper dermis.


Sensory neuropathy revealing necrotizing vasculitis during infliximab therapy for rheumatoid arthritis.


In this case, an evaluation for organism-specific pathology led to early identification of a potentially curable large bowel lesion.


Improvement both clinically and by objective assessment, was observed on intravenous CyA therapy, but was not sustained when the drug was given orally for several months.


Examination revealed facial erythema and eczema, ectropion, blepharitis, chemosis, lid teleangectasia, and contact lens-related corneal edema.


Further benefit was gained from a course of calcitonin.


She was diagnosed with Epstein-Barr virus-associated polymorphic lymphoproliferative disorder (LPD) due to immunodeficiency caused by MTX administration.


After treatment with topical corticosteroids, antiglaucoma agents, cycloplegics, hypertonic saline and tears supplements, 27 (93%) eyes recovered completely within 3-14 days.


The combination of raltitrexed (Tomudex) and mitomycin-C in the treatment of advanced colorectal cancer--a phase II study.


Eleven weeks later he developed Pneumocystis carinii pneumonia.


Pamidronate was used and calcium concentrations normalized by 24 hours after treatment.


While the tyrosine kinase inhibitor imatinib, which has been recently shown to represent the treatment of choice for GIST, is primarily metabolized by the liver, data on the pharmacokinetics and the tolerability of imatinib in patients with increased cholestasis parameters are not yet available.


The patient with a pre-excitation syndrome is usually managed in a coronary care unit.


CONCLUSIONS: Both the immunomodulatory effects of octreotide on intrathyroidal lymphocytes and rapid reductions in TSH may contribute to the onset of Graves' disease.


A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.


The literature on garlic burns is reviewed.


We report a patient with inoperable pancreatic cancer who developed gastrointestinal bleeding secondary to radiation-recall related to gemcitabine and review literature.


A study of the absorption and disappearance of dexamethasone from the circulation in response to a (1 mg oral dose indicated that the steroid was absorbed normally but was cleared more rapidly from the circulation of these two patients than from normal controls.


Retinal abnormalities, including retinal hemorrhage and "cotton-wool" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C.


Discontinuation of these two antibiotics results in an immediate decline of the thrombocyte count to normal values within three weeks.


Although the association between SJS/TEN and the sulfonamide class of antibiotics is well established, the increasing prevalence of CA-MRSA has left practitioners with limited regimens to effectively treat skin and soft tissue infections (SSTIs) in the outpatient setting.


Propoxyphene overdose is known to cause widening of the QRS complex on ECG.


Total lithotomy time was four hours.


Amiodarone-induced thyrotoxicosis associated with thyrotropin receptor antibody.


We also review the diagnostic and therapeutic implications of this paradoxical complication associated with treatment of bone lesions in MM.


Serum free levels and evaluation anticonvulsant drug interactions.


Multiple hepatic tumors and peliosis hepatis in Fanconi's anemia treated with androgens.


Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy.


Depression is a common problem in elderly patients and frequently is treated with antidepressants.


A 62-year-old Japanese man who was positive for hepatitis B surface antigen (HBsAg) and anti-HBe antibody, underwent chemotherapy for non-Hodgkin's lymphoma (NHL).


We conclude that opiate medication may inhibit - in a life-threatening way - the organism's ability to respond to physical, emotional or metabolic stressors.


A 68-year-old female with mild diabetes mellitus was admitted because of acute liver dysfunction due to autoimmune hepatitis.


Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura.


DISCUSSION: Acute ITB withdrawal syndrome occurs frequently in cases of malfunctioning intrathecal infusion pumps or catheters.


Further study revealed that all three patients had low plasma renin activity and nonsuppresible plasma aldosterone levels after saline infusion.


In addition, the patients did not demonstrate evidence of hypothalamic-pituitary-adrenal axis suppression.


The literature on human aflatoxicosis shows that the presentation may be acute, subacute and chronic.


STUDY DESIGN: A case report.


Reviewing data on these patients and recent literature indicate that fatal marrow aplasia seems to occur more frequently in sero-negative women who respond well to therapy with gold salts.


He received further chemotherapy without G-CSF and without any recurrence of the raised leucocyte count but failed to achieve full remission.


MRI revealed signal abnormalities within the corpus callosum, basal ganglia, and brainstem.


This article presents a patient with hypoparathyroidism who was treated with calcium carbonate and calcitriol resulting in two admissions to the hospital for milk-alkali syndrome.


On rechallenge she developed severe dyspnea, cough, and wheezing 20 minutes after administration.


Complete clinical resolution was observed with oral and topical antimycotic treatment.


A final dosage of 60 mg/kg was used.


It is recommended that patients be diligently screened before starting TNF-alpha antagonist therapy and that vigilance for symptoms of demyelinating disease/multiple sclerosis be included in follow-up examinations during treatment with these drugs.


The mechanism of the electrocardiogram changes was considered to be caused by the two drugs synergistic sodium channel blocking effects.


Treating stridor with opioids: a challenging case of paradoxical vocal cord movement.


Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.


This case highlights the need to monitor liver enzymes in patients treated with 6-TG and identifies the need for additional research focused on the mechanism of thiopurine-induced hepatic injury.


Reversible valproic acid-induced dementia was documented in a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities documented by serial neuropsychological studies.


Pneumonitis and pneumatoceles following accidental hydrocarbon aspiration in children.


Although this drug interaction is well established in the literature, we found no documented cases that address its effects on anticoagulation parameters in patients requiring repeated cycles of 5-fluorouracil and continuous warfarin therapy.


The patient had already been on methimazole for a month when she was admitted to the Pediatric Unit with the diagnosis of sepsis.


AIMS: To investigate a worker who experienced systemic and respiratory symptoms when exposed to a vanadium containing powder used as a catalyst in the production of maleic anhydride.


Tonic status epilepticus presenting as confusional state.


We describe a premenopausal woman who, while having tamoxifen due to a diagnosis of in situ ductal carcinoma, developed endometriosis requiring surgery.


Blood, urine, and throat cultures were negative.


The patient's INR increased 11-14 days after each cycle of chemotherapy with 5-fluorouracil and leucovorin.


METHODS: Repeated blood samples were drawn in a patient with severe acyclovir overdose who developed coma and nonoliguric renal failure.


The increasing incidence of both atrial fibrillation and colon cancer with age could potentially require the concomitant use of 5-FU, levamisole, and warfarin.


Surgically induced necrotizing scleritis in a patient with ankylosing spondylitis.


BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.


CONCLUSION: A possible pharmacokinetic interaction between Dantrolene and Oxybutynin should be borne in mind when considering Carbamazepine medication for a patient with a spinal cord lesion.


DISCUSSION: Eye burns followed by calcifications follow two different major patterns: the corrosive substance contained calcium or the continued therapy was applied with phosphate-buffered eye drops.


He was referred after a percutaneous liver biopsy which revealed a moderately differentiated HCC.


It is imperative that dermatologists have a keen awareness of this possible adverse event given the increased use of this class of drugs.


Linezolid may be a good alternative for treatment of ventriculoperitoneal shunt infections in cases of vancomycin-resistant organisms or apparent treatment failures.


In addition, loading with one low oral dose of serine produced psychotic symptoms 5 h later which lasted 3-6 h.


He had previously received several treatments including two courses of fludarabine.


We describe two patients with rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis in whom accelerated nodulosis developed during methotrexate therapy.


Acute elevation of the ST segment in several ECG leads was observed in seven patients with bacterial shock during the course of therapy.


Intraocular pressure (IOP) was not able to be controlled medically, however, and filtering surgery 20 days post laser treatment was required.


To our knowledge, this is the first report of t-MDS with der(17)t(12;17)(q13;p13) after treatment for CLL.


Central venous catheter-related Rhodotorula rubra fungemia.


This observation suggest that linezolid is a promising drug for the treatment of prosthetic joint infections due to MRSA or other Gram-positive pathogens, particularly when other therapeutic approaches are not feasible or a long-term antibiotic therapy is required.


In each instance, the plasma thrombosis-inducing activity (TIA) appeared one to three days after chemotherapy and subsided subsequently.


Five cases of clindamycin-associated pseudomembranous colitis in leukaemic patients are reported.


No reactions occurred to methylprednisolone and hydrocortisone.


Only papers published in English were reviewed.


Severe visual loss after a single dose of vincristine in a patient with spinal cord astrocytoma.


Small intestinal resection with loss of small intestinal absorptive area was not a risk factor for the development of osteonecrosis.


Chloroquine treatment remains the most common single treatment of malaria in sub-Saharan Africa.


A 73-year-old man with two previous mitral valve replacements presented with prosthetic valve infective endocarditis.


Graft versus host-like illness in a child with phenobarbital hypersensitivity.


We studied 13 healthy volunteer subjects, performing three hepatobiliary scans in each one.


Because these changes may be effects of parathyroid hormone (PTH), PTH was measured in 19 patients receiving lithium.


Assessment of cortisol response was by insulin-induced hypoglycaemia in three cases, by short tetracosactrin test in two, and by low-dose tetracosactrin and 24-hour urinary cortisol/creatinine ratio in one.


We describe two patients who developed malignant myelosclerosis after receiving cytotoxic chemotherapy, one for Hodgkin's disease, and the other for membranous nephritis.


Considering that this article provides findings from a single patient, the authors use this experience to discuss and emphasize the importance of clinical control of barbiturates in psychiatry.


CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa.


Use of the Naranjo adverse drug reaction probability scale indicated a probable association between this patient's reduced A1C levels and erythropoietin therapy.


Our analysis reveals that this method is useful, but also highlights potential areas for its improvement.


RESULTS: Dual desensitization resulted in marked improvement in her symptoms.


Multiple keratoacanthomas developed on the face of a woman after radiation therapy to the nasal sinuses.


Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.


The treatment of Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome.


Methotrexate-induced leukoencephalopathy is treatable with high-dose folinic acid: a case report and analysis of the literature.


The lesion was recurrent, with evidence of desquamation.


This case report underscores the relationship between genetic background, environmental factors, drug-induced immunosuppression and the evolution of this peculiar neoplasm.


Limited data suggest that TNF-alpha inhibitors may facilitate uncontrolled hepatitis B viral replication.


Severe akathisia during olanzapine treatment of acute schizophrenia.


Neither our patient's clinical symptoms nor her serologic parameters improved possibly because of the low dosage and/or short duration of cyclosporine A treatment.


We present the clinical history/presentation investigation and the outcome of the treatment.


We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.


However, an increasing number of reports are appearing suggesting more than just a casual relationship between leukemia and the use of alkylating agents.


A rating system to display the effect of clozapine on individual parameters as well as on the over-all state was devised for this study.


METHODS: A 54-year-old muscular, short-statured man underwent posterior cervical laminectomy from C3-C5 without instrumentation and left C5 foraminotomy.


Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.


PURPOSE: To report the occurrence of focal segmental glomerulosclerosis (FSGS) in children with acute lymphocytic leukemia (ALL), discuss pathogenesis and problems in management.


After adequate hydration and administration of oral colchicines, the patient's right knee pain subsided and the uric acid serum level returned to normal.


The sensory overstimulation is characterized by a subjective experience of sensory overload and a relative resistance to lidocaine local anesthesia.


Prothipendylhydrochloride-induced priapism: case report.


Nevirapine is a non-nucleoside reverse transcriptase inhibitor widely used in combination with other antiretroviral agents for the treatment of HIV infection.


Alopecia, nausea, and vomiting were attributed to the cyclophosphamide component of the therapy.


No patient had a history of previous chronic lung disease; most were not immunocompromised.


The mechanisms responsible for these conditions currently remain unclear.


This may also represent an alternative to ex-vivo expansion and deserves further investigation.


Two patients were supported with a right VAD, one with a left VAD, and one with a biventricular VAD.


The serious clinical state of NE patients requires very frequent surgical consultations; however, in a few particular cases of NE, e.g., perforation of the bowels, a surgical intervention is necessary.


METHODS: The investigations were carried out on 186 liver biopsies and 5 autopsies.


We present an example of this complication that we recently saw in our department which on initial presentation appeared to be squamous cell carcinoma.


BACKGROUND: Myasthenia gravis (MG) is a neuromuscular disease sometimes associated with severe psychiatric complications.


A case report.


Skin rash and splinter hemorrhages from ganciclovir.


Warfarin (coumadin) is the most common oral anticoagulant used for chronic anticoagulant therapy and most patients requiring such therapy are elderly (greater than 65 years old).


Calcification and ossification of the spinal arachnoid after intrathecal administration of Depo-Medrol.


Hereby we describe the first case of ARF in a HIV-infected patient, who received IVIG stabilized with maltose for the treatment of HIV-related thrombocytopenic purpura.


Serial lymph node biopsies showed the progression of this disorder from a pleomorphic immunoblastic proliferation to a lymphocyte-depleted, fibrotic process, in parallel with a decline from hyper- to hypogammaglobulinemia.


Although the management of catheter-related Rhodotorula fungemia infections remains controversial, resolution of the underlying disease is more important than catheter removal for recovery from Rhodotorula rubra fungemia.


When infection of the instrumented cage is diagnosed, emergency debridement with or without removal of implants, including the cage, appropriate wound closure, and the administration of potent antibiotics is the standard treatment.


Staphylococcus species, Streptococcus species, and less commonly, gram-negative rods comprise the majority of isolated organisms.


An organic mental syndrome developed in a patient soon after he underwent repair of a dissecting thoracic aortic aneurysm.


SS was diagnosed using the Hunter Criteria (use of multiple serotonergic drugs preoperatively, hypertonia, and spontaneous clonus) and was presumed to have been triggered by the combination of perioperative and intraoperative serotonergic medications.


On admission to the hospital, the patient was diagnosed and treated as having cholangitis.


In both cases, benefit of therapy with cetuximab could be demonstrated.


She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.


Liver biopsy revealed a reduction in activity of carbamyl phosphate synthetase-I, an enzyme obligated for transformation of ammonia to urea in the urea cycle.


Both developed acute erythroid leukemia, 98 and 71 months after the original diagnosis of myeloma, and died of subarachnoid hemorrhage and cardiac arrest.


These results suggest that the pathogenesis of pseudotumor cerebri might be associated with the hypercoagulable state which was induced by glucocorticoid therapy and nephrotic syndrome.


In 1 case the drug appears to have exacerbated underlying myasthenic weakness, whereas in the other 3 cases, de novo antibody formation appears to be most likely.


Pentavalent antimony is still the drug of choice in the treatment of visceral leishmaniasis.


Patients should be monitored for these potentially serious side-effects while on this drug.


The majority of patients were men and had a relatively early onset of parkinsonian symptomatology.


Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands.


Under prophylactic treatment with low-dose trimipramine (50 mg) or nefazodone (200 mg/day) therapy with IFN-alpha 3 x 3 mio IE/week was re-established after several months and again 2 years later adding ribavirin 1200 mg/day, a virustaticum.


Seven of 8 evaluable patients remain alive and free of recurrence with a median follow-up of 13 months.


We describe a case of intraoperative gelatine-induced anaphylaxis whose diagnosis was delayed as the use of gelatine during surgical procedures was omitted for two times in patient's medical records.


Data from the Cincinnati Transplant Tumor Registry indicate that of 662 patients treated for posttransplant lymphoma, 277 patients died of cancer and 137 died of other causes, of which infection was a major factor.


A failure to rely on serum free levels of the anti-convulsant under these circumstances can easily result in poor clinical decisions.


Protamine sulphate for treatment of severe post-reperfusion coagulopathy in pediatric liver transplantation.


The peritoneal dialysis catheter was removed in 53% of cases, although this was rarely considered necessary for cure of tuberculosis.


Most electrophysiological responses were usually just within normal limits; two patients had subnormal Arden electro-oculography indices; and one patient showed an abnormally delayed photopic b wave.


A short course of treatment with topical aluminum chloride resulted in a remarkable response in 1 week.


Arrhythmias are the most common major complications encountered during pediatric cardiac catheterizations.


Development of platinum hypersensitivity can limit therapeutic options.


A preliminary study of a combination of pentoxifylline (PTX) and tocopherol (vit-E) has shown clinical activity with 50% superficial RIF regression at 6 months in half of the patients studied.


The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.


Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.


Use of tumor necrosis factor-alpha inhibitors in patients with chronic hepatitis B infection.


She was admitted following a fall and, after being given metoclopramide, developed movement disorder and a period of unresponsiveness.


Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.


Progression of the clinical picture was documented over 15 years of follow-up.


However, even with an initial dose of 0.5 mg, hypotension with consciousness disturbance developed in three hypertensive patients with recent cerebral hemorrhage.


Of the 10 patients with MDS, 6 were suffering from refractory anaemia with sideroblasts (RAS) and 4 from refractory anaemia with an excess of blasts.


Tamoxifen exhibits agonistic properties on the uterus.


Linear IgA bullous dermatosis occurring after carbamazepine.


The left C4 pedicle screw was proven to breach the transverse foramen.


CONCLUSION: The administration of tissue plasminogen activator was responsible for the large extent of hemorrhage and should be considered in the differential diagnosis of hemorrhagic choroidal detachment.


A review of the literature is also presented.


A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.


Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed.


A woman with Cushing's syndrome after use of an Indonesian herb: a case report.


Pharmacists need to be vigilant in establishing a dialogue with their patients about the pros and cons of herbal product use, particularly with prescription medications.


Hepatotoxicity of hycanthone in patients with metastatic breast cancer.


A 42-year-old woman was admitted to the hospital to receive intravenous acyclovir for a herpes zoster infection.


RATIONALE: The atypical antipsychotic clozapine is effective in the treatment of patients with refractory schizophrenia.


In this case report, osteonecrosis of the maxilla in a 48-year-old female patient who was treated for acute myelogenous leukemia is presented.


Enoxaparin is the current anticoagulant of choice with advantages for the treatment of neonatal thrombosis.


Postoperatively, the first two patients treated with 1 to 2 cc of thrombin were slow to awaken; one had evidence of vasospasm by transcranial Doppler ultrasound studies and multiple infarcts on cranial computerized tomography, while the other had a moderate-sized frontal hematoma with intracranial hypertension.


We report a case of a 74-year-old man with chronic lymphocytic leukemia who received high-dose intermittent chlorambucil and prednisone every two weeks.


Serial physiologic and echocardiographic parameters were followed.


However, in spite of the early successful treatment with dantrolene the MH reaction recurred 12 h after the initial symptoms.


Nevertheless, overdosage and intoxication are well documented.


These observations suggest that G-CSF/Ara-C therapy may be useful in the treatment of high-risk AML.


Methotrexate (MTX) is a commonly used second line agent for RA, and there have been several recent reports of Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder in MTX-treated RA patients.


Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature.


The shunt infection was controlled by removal of the shunt and a combination of systemic and intraventricular administration of amikacin, and oral administration of ofloxacin.


Transient phenytoin induced IgA deficiency and permanent IgE increase.


We report a patient with multiple myeloma who suffered from hyperammonemia after a second stem cell autograft.


Early bacterial keratitis after laser-assisted subepithelial keratectomy.


In this report, two cases of ET which evolved into AL without prior exposure to radiation or alkylating agents, and which were treated with long-term hydroxyurea therapy, are described.


We report a case of severe hyperphosphatemia resulting in transient acute renal failure corrected rapidly by hemodialysis.


In addition, she had a central scotoma (RE > LE) on automated visual field analysis (Humphrey central 30 degrees ).


Lipoid pneumonia: a silent complication of mineral oil aspiration.


We also report, for comparison, a patient treated with conventional AmB, and preliminary studies in mice comparing the two agents.


The other woman had rheumatoid arthritis and developed acute tubular necrosis after treatment with gentamicin and cefoxitin.


Mycobacterium interface keratitis after laser in situ keratomileusis.


Although adverse sequelae to these episodes of hypertension were not noticed, this report documents the uptake of phenylephrine from topical ocular application and suggests the need for dose-response measurements for this adjunct to mydriatic treatment in dogs.


CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.


BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.


The clinical features and different drug-induced movement scales showed an outstanding improvement after tetrabenazine was started.


All patients presented with sudden painless dimness of vision with photophobia.


BACKGROUND: We describe the ophthalmic features and clinical course of two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) that developed after intravitreal triamcinolone acetonide (IVTA) injection.


Report of two cases.


The patient had leukocytosis with a large percentage of atypical lymphocytes on peripheral smear and liver dysfunction.


In a female with acute lymphoblastic leukemia, inadvertent doxorubicin administration intrathecally caused severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus.


We describe a patient who, after receiving his first dose of pregabalin to relieve neuropathic pain, presented with a negative myoclonus.


This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel.


Additionally, danazol produces hepatocellular damage in approximately 10% of women.


Treatment with CSA was started after a nonresponding course of prednisone.


A patient with seropositive rheumatoid arthritis developed ascites while taking weekly doses of methotrexate (MTX).


Chemotherapy-related hemolytic-uremic syndrome after the treatment of head and neck cancer.


The treatment of FMF attacks in patients who cannot use colchicine is an important problem.


Serious phenytoin hypersensitivity reactions may appear as dermatologic, lymphoid, or hepatic syndromes.


The authors report two cases of catechol-O-methyltransferase (COMT) inhibitor-induced asymptomatic hepatic dysfunction in women with Parkinson disease.


Tetracycline-induced renal hypophosphatemia in a patient with a syndrome of inappropriate secretion of antidiuretic hormone.


CASE SUMMARY: A 6.1-year-old child received cyclosporine and methotrexate for acute graft-versus-host disease (aGVHD) prophylaxis after his first HSCT for acute myeloblastic leukemia.


The patient was successfully managed with clopidogrel therapy during the 16 months follow-up without recurrent thrombotic or hemorrhagic events.


The success of the treatment was documented by the criterion of a return to the normal cardiorespiratory parameters a few hours after the start of the thrombolytic treatment.


Both eyes became atrophied and had poor visual outcome: 10/200 in one patient and no light perception in the other at 6 months after IVTA injection.


Agranulocytosis associated with ticlopidine: a possible benefit with filgastim.


Prevention by mass media should mainly focus on the medical fatalities of abuse and not emphasize the hallucinogenic effects, presumably increasing unwanted interest for these plants among youths.


Trimethoprim-sulfamethoxazole-induced hepatotoxicity in a pediatric patient.


Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia.


The patient had seronegative (rheumatoid factor negative) poliarticular form of JRA and was receiving low dose weekly Methotrexate (MTX) during the past 2 years.


In this case senna was likely the cause of a subacute cholestatic hepatitis exemplifying again the potential role of herbal related liver injury.


We report the case of a patient with chronic lymphocytic leukemia (CLL) who developed fatal intravascular autoimmune hemolytic anemia (AIHA) after fludarabine treatment.


Two cases of bipolar affective disorder with tardive dystonic symptoms seemed to improve only with mood elevation, whether the latter occurred spontaneously or was 'induced' pharmacologically.


Renal biopsy of these children showed classical BMTN histology, and the renal manifestations progressed quickly; the patient in case 1 became dialysis dependent by 1 year post-bone marrow transplant.


Full recovery occurred because of early pick up, emphasizing the need for careful fluid balance monitoring of patients receiving cisplatin chemotherapy.


Ten months after the injection, visual acuity remained at 20/50, and intraocular pressure measured 15 mm Hg without antiglaucomatous therapy taken.


Review of existing literature shows that in immunocompromised patients, GI cryptococcosis invariably coexists with disseminated cryptococcosis, often lacks prominent GI symptomatology, and is primarily diagnosed postmortem.


The literature search revealed 22 cases of hypersensitivity reaction to cyclosporine.


Among atypical antipsychotic, clozapine, risperidone and olanzapine have been reported to be associated with the condition.


This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel.


They received trihexyphenidyl with good results.


Her clinical course was complicated and the catecholamine and cortisol concentrations were still elevated 24 h after start of treatment.


Clinical neurophysiological and neuroradiological findings and finally neuropathological studies in 2 patients resembled those found in vitamin-B12-deficiency-syndrome with a predominant affection of the spinal posterior column and the corticospinal tracts.


The phenotype overlaps with that of attention deficit disorder, raising the possibility of subtypes of attention deficit disorder that have a peripheral sensory cause and novel forms of therapy.


One major source of risk to patients is intraarterial or intraneural injections.


Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin.


Administration of sumatriptan in subarachnoid haemorrhage (SAH) patients, misdiagnosed as migraine patients, may induce symptomatic cerebral vasospasm with potentially dangerous consequences.


Until the mechanism of action responsible for fluid overload is known, we suggest that thiazolidinediones be administered with caution in all patients.


It is extremely resistant to standard treatment, and confers a poor prognosis for this disease.


Based on these findings and since the patient had no signs of infection, his physician instructed him to discontinue the drug.


Pulmonary hemorrhage is an uncommon feature in the HUS, and seems to appear especially in the HUS associated with MMC therapy.


Many of the uncommon causes of CAPD peritonitis have been reviewed, with special emphasis on antimicrobial therapy and whether catheter removal was required.


This case indicates that C. indologenes infection can occur in diabetic children without ventilator or central venous catheter and might be treated with a single agent after in vitro susceptibility tests have been performed.


Approximately 15 min after the first administration of nebulised morphine the patient became markedly bradypneic (respiratory rate: 4-5 bpm), hypotensive (BP 70/40 mmHg), and responded only partially to command.


Thus, it is important for dermatologists treating patients with diabetes and antitumor necrosis factor-alpha agents for psoriasis to be aware of potential hypoglycemia and to adjust antidiabetes therapy accordingly.


No other drugs were detected.


Rapidly progressive glomerulonephritis during antituberculous therapy.


Disopyramide (Norpace) is a recently released antiarrhythmic agent with quinidine-like actions, but structurally unique.


RESULTS: Both patients were negative for islet cell antibodies.


She had a history of diabetes and angina pectoris.


She recovered from the event without apparent chronic cardiac dysfunction.


Under constant mechanical ventilator settings, a highly significant linear correlation between peak airway pressure and arterial pCO(2)(r: 0.98 P<0.001) was observed.


RESULTS: The use of ECT in patients with MG is a viable therapeutic option when psychiatric complications secondary to MG or its treatment do not respond to psychotropic medications.


The patient's symptoms were relieved with 0.5 mg intravenous atropine and she recovered uneventfully.


It appears that specific MEFV mutations are probably not the sole determinants of phenotype, and that unknown environmental factors or modifying genes act as accomplices in this disease.


PURPOSE: To evaluate the efficacy and safety of topical imiquimod 5% cream for the treatment of eyelid basal cell carcinoma.


We speculated that SLE associated with systemic vasculitis and uremic milieu over a number of years may represent the perfect preexisting condition for calcific arteriolopathy to occur following which several factors including chronic administration of corticosteroids, photosensitivity in lupus, and significant weight loss may have contributed to acral gangrene and mesenteric ischemia.


A 43-year-old man presented suffering from decreasing vision in both eyes for 3 months.


We report a case of pediatric bupropion ingestion resulting in multiple seizures.


Although the aetiology of their cerebral dysfunction can not be definitely ascertained this case series emphasizes the need for long-term prospective studies in patients with diabetes of long duration to assess the impact of the disorder on cognitive and social abilities particularly where there is evidence of cerebral dysfunction.


Clotrimazole is an antifungal agent that has been shown to have excellent in vitro activity against most strains of Acanthamoeba.


Three of the 36 patients were receiving aspirin for the treatment of juvenile rheumatoid arthritis.


A gradual spontaneous recovery of normal hematopoiesis followed after the lenalidomide discontinuation.


While doxorubicin was administered, the patient presented thoracic pain and breathing distress due to superior vena cava perforation by the central catheter and subsequent extravasation of the drug into the mediastinum.


Hypersensitivity reactions to aromatic anticonvulsants are associated with anti-liver microsomal antibodies which recognise rodent proteins.


Three patients with a cellular immunodeficiency were treated with rifabutin, clarithromycin and ethambutol for a disseminated infection with Mycobacterium avium-intracellulare complex (MAC).


Fatal intoxication using amantadine and pramipexole in a uremic patient.


On the third occasion the patient redeveloped severe hypotension and a generalised rash during general anaesthesia.


All three patients were stabilized and their tachycardia was controlled with digoxin.


Hemodynamic collapse following labetalol administration in preeclampsia.


Its radiosensitizing effect may be worth exploring at a lower dose level.


Despite cessation of daunomycin, she demonstrated fluctuating systolic function in relation to ATRA administration.


One year later, she has minimal joint discomfort and no rash or gastrointestinal symptoms despite also discontinuing prednisone and methotrexate.


Disseminated Nocardia infection has a high mortality and morbidity rate in solid organ transplant recipients, even when appropriate antibiotics are given.


Several different preparations are available including interferon beta 1a (Avonex, Rebif) and interferon beta 1b (Betaferon/Betaseron).


However, re-initiation of sunitinib treatment was followed by bilateral breast enlargement again.


CONCLUSIONS: We present a case of a patient with CML who developed KS 12 months after starting treatment with imatinib 400 mg/d.


We speculate that the beneficial effect of IFN-alpha in the treatment of PTLD is directly related to the inhibition of type 2 helper (Th2-like) T-cells.


If radiotherapy over extensive areas of the body is needed, the use of IL-2 must be postponed until radiotherapy is completed.


Dipyrone-induced granulocytopenia: a case for awareness.


Although dacryocystography showed a dilated and partially obstructed nasolacrimal system, ultrasound examination was able to demonstrate a mass in the nasolacrimal duct.


These cases serve as a timely reminder of the importance of taking an accurate drug history in emergency situations.


Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation.


Rifampicin-induced renal failure.


Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.


Fixed drug eruption to rofecoxib.


Finally, it was decreased to 40 BU in the 36th week.


Riluzole is a new drug representing the first active treatment for amyotrophic lateral sclerosis.


These patients require not only treatment of their acute medical problems but also specialized multidisciplinary acute rehabilitation starting as early as possible during their hospital stay.


Anaphylactoid reaction to rattlesnake envenomation.


It is very likely that the dexamethasone used in the antiemetic drug regimen contributed to the development of osteonecrosis in these patients.


A bubble in the inferior sagittal sinus was observed on the day of the stroke, which then disappeared within 24 hours.


Eight of the 14 women used no contraception at the time of the exposed pregnancy; 13 of the 14 women did not use two forms of contraception.


Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.


This paper reviews the development of steroid therapy for spinal cord injuries, the mechanisms of action, and the nursing care associated with its use.


Subsequent investigation revealed that the factory produces phenylpropanolamine and that both patients, shortly before becoming ill, were inadvertently exposed to methyl nitrite, a critical reagent in this production.


An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.


Transient lymphomatoid papulosis in mycosis fungoides.


This latest (third) report suggests that the safety profile should be reexamined and at least raises the question of potential renal toxicity of interferons in MS.


The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy.


Using this test we diagnosed CMV infection in the fetus of a 30-year-old renal transplant recipient.


Pancytopenia is already present in GD patients and it is reasonable to expect an increased risk of hematological toxicity in treating solid tumors in these patients.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


Malignant myelosclerosis or acute myelofibrosis is a rare acute myeloproliferative disorder characterized by pancytopenia, myeloblastosis and marrow fibrosis.


In light of the widespread use of bleomycin, this complication may be under-appreciated.


Initially, this reaction was thought to be a result of a drug allergy, but upon further review, we determined that it was JHR.


Priapism is a rare but serious adverse effect of psychotropic drugs where antipsychotic agents were implicated in 15 to 26% of priapism associated with medications.


We suggest that the duration of chemotherapy required to achieve a cure in patients with ovarian carcinoma in complete remission can be determined only by prospective controlled trials.


We report a case of a previously healthy, postmenopausal woman who developed anticonvulsant hypersensitivity syndrome while taking Bellamine S (belladonna alkaloids; ergotamine; phenobarbital) for hot flashes.


However, data published since acyclovir became available do not indicate increased adverse effects related to its use in pregnancy, especially if prescribed in selected situations, such as disseminated primary herpes simplex infections or maternal varicella pneumonia.


Double jeopardy?


Recently, RA has been added to the post-BMT therapy in children with stage IV neuroblastoma.


The association of systemic inflammatory disorders with osteonecrosis and the possible association with vascular thrombosis are discussed.


The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.


Along with receiving multiple other drugs, the patient was started on a continuous i.v. infusion of dobutamine 3 mug/kg/min.


In all patients, oral prednisolone (PSL) alternative day therapy was attempted and three patients responded very well (complete remission 2, partial remission 1).


Chylous ascites, a rare compliation following retroperitoneal lymph node dissection, has not been reported as a means of spread of testicular cancer.


We report 2 cases of AIT: in one case, amiodarone was interrupted; in the other case, amiodarone was continued because of recurrent ventricular tachycardia resistant to classical antiarrhythmic drugs.


Hyponatremic seizures after suprapubic catheter placement in 7-year-old child.


Such anagen effluvium with lichenoid eruption following INH therapy has not been observed previously.


CASE DESCRIPTION: A 37-year-old woman was started on weekly interferon beta-1a (IFN beta-1a) following a diagnosis of multiple sclerosis (MS).


Although the true frequency of adverse fetal effects has yet to be determined, because of the debilitating and lethal nature of the fetal damage when it occurs, it is our recommendation that ACE inhibitors not be used in pregnancy, particularly in the second and third trimesters.


He had been treated with oral cyclophosphamide for 13 years.


FK506 dose level was maintained and then reduced.


This paper outlines the indications and precautions for use and side effects of monoamine oxidase inhibitors in the treatment of depression in elderly patients.


A 64-year-old man with schizophrenia developed myoclonic jerks when given higher doses of quetiapine.


A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.


Thus this patient's hyponatremia cannot be accounted for solely by changes in external water and electrolyte balance; the rapidity with which changes were produced suggests that osmolar inactivation, probably intracellularly, may contribute to the severe hypotonicity seen in some patients.


Visual hallucinations associated with zonisamide.


One RA patient and one AA patient have received rEpo as maintenance therapy for more than 64 and 100 weeks, respectively.


The presence of inappropriate sexual behaviors in individuals with autistic disorder is one of the important factors disturbing their social adaptation and distressing their families and environment.


The conditions treated were: Hodgkin's disease (four patients), primary amyloidosis, primary macroglobulinemia, malignant lymphoma, multiple myeloma, and carcinoma of the tonsil.


CONCLUSIONS: This patient's rhabdomyolysis was probably induced by sertraline therapy.


Usefulness of antiplatelet drugs in the management of heparin-associated thrombocytopenia and thrombosis.


Multifocal disseminated lipoatrophy secondary to intravenous corticosteroid administration in a patient with adrenal insufficiency.


Tumors were assessed for immunohistochemical evidence of mTORC1 activation and genetic evidence of alterations in TSC1 and TSC2.


On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg.


Visual field improvement after neodymium: YAG laser puncture of miotic cysts.


The mutants K122R, F134L and G145A in our patient have not been tested for their sensitivity to Architect and Murex assays by the previous investigators and might represent the escape mutants to these assays.


The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.


Growth hormone deficiency after localized ganglioneuroblastoma: A case report.


N-acetylcysteine and Unverricht-Lundborg disease: variable response and possible side effects.


We present the case of a 58-year-old woman who ingested more than 35 g of caffeine in a suicide attempt.


Clinical toxicity of reserpine in hospitalized patients: a report from the Boston Collaborative Drug Surveillance Program.


Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.


We ultimately speculated that corticosteroid withdrawal induced the depressive symptoms in this case.


OBJECTIVE: Anastrozole is a selective aromatase inhibitor and is used for the hormonal treatment of postmenopausal breast cancer.


RESULTS: One patient progressed to chronic renal failure and required prolonged dialysis followed by renal transplantation, though the leukemia remained in remission.


The wound and tissue cultures were negative.


Blood biochemistry revealed severe liver dysfunction, although no markers including hepatitis virus or autoantibodies associated with autoimmune liver diseases were detected.


The use of antithymocyte globulin in the treatment of severe aplastic anemia in children.


The response to clozapine appears to be specific and relapses occurred when maintenance medication was stopped.


A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.


Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature.


Uncontrolled headache induced by oxcarbazepine.


Parenteral challenge with suspected sensitizing agents confirmed methicillin as the likely offender.


We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).


Captopril is an angiotensin-converting enzyme (ACE) inhibitor and their cutaneous side-effects are documented, but little has been published concerning the usefulness of patch test when they occur.


Cutaneous infection is rare and about 71 cases have been described, mainly in Europe in immunocompromised hosts.


Use of leflunomide in an allogeneic bone marrow transplant recipient with refractory cytomegalovirus infection.


IMPLICATIONS: Switching from bupivacaine to lidocaine may improve intrathecal morphine analgesia in advanced cancer patients, possibly because of different spinal mechanisms limiting the hyperalgesic processes.


DISCUSSION: The Naranjo probability scale indicates C. mukul as the possible cause of rhabdomyolysis in our patient.


The participants all reported heightened sensitivity to one or several odors which could not fully be explained by the potential explanatory models of anticipatory nausea and vomiting, pseudohallucinations, or increased chemical sensitivity.


Transient phenytoin induced IgA deficiency and permanent IgE increase.


She had received subcutaneous heparin as prophylaxis for deep vein thrombosis during a 5-day hospitalization for postpartum cardiomyopathy.


Even after a strict warning, he took another quinine tablet that evening, which triggered his fifth episode of severe thrombocytopenia, and confirmed the etiology of quinine-induced thrombocytopenia.


The routine immunologic studies were normal.


Unique to this case, however, was the substitution of another angiotensin-converting enzyme inhibitor, enalapril, without exacerbation of the pemphigus.


Venlafaxine blocks the specific monoamine transporters and is devoid of significant action on muscarinic cholinergic receptors.


The authors describe two patients with this disease who initially had findings suggestive of an optic neuropathy.


CONCLUSIONS: Itraconazole-induced liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia.


Here we report a case of R. equi-associated pulmonary abscess in a renal transplant recipient successfully treated with a combination of carbapenem and teicoplanin.


Treatment of restenosis after bare-metal and drug-eluting stenting of an aorto-ostial lesion: challenges associated with excessive stent overhang.


Intravenous warfarin as an alternative for anticoagulation.


Aggressive combination chemotherapy was required to reverse progressive thrombocytopenia and pulmonary involvement.


This treatment resulted in remission of the vasculitis.


We have shown that CMV-polymerase chain reaction of AF is a useful diagnostic test for congenital CMV infection.


In four of the five patients, right-sided focal seizures were subsequently noted.


The proportions of lymphocyte subsets, as defined with monoclonal antibodies, and the proliferative response to mitogens were normal.


RESULTS: Vitritis occurred in 8 patients (12 episodes), 2 to 23 months postoperatively.


Our objective is to present a retrospective analysis of the DWI findings in four patients who suffered subacute neurotoxicity after intrathecal MTX.


On rechallenging the patient with the drug following the implantation of a permanent pacemaker, intermittent complete heart block developed.


Only one case of severe symptomatic hepatitis occurring after pulse therapy with itraconazole for onychomycosis and requiring transplantation has been reported previously.


Our report lends further support to the assumption that COX-2 inhibitors, as a class, can be as nephrotoxic as their nonselective predecessors.


Squamous-cell carcinoma arising in a basal-cell epithelioma treated with 5-fluorouracil.


A young woman with epilepsy had tonic-clonic seizures during antineoplastic therapy with adriamycin and cisplatin.


Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.


Other NSAIDs of the propionic acid family can also cause pseudoporphyria.


In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.


Collagenous colitis as a subtype of microscopic colitis is a rare cause of chronic diarrhea with unknown pathogenesis.


We conclude that symptoms of a postdural puncture headache can mimic those of postpartum preeclampsia.


Despite the known pulmonary side effects of nitrofurantoin, there is no report of this toxicity occurring in pregnant patients.


There is no study on the incidence rate among children with systemic malignancies.


Both patients made an uneventful recovery.


Treatment with aripiprazole resulted in a reduction in the frequency, duration, and severity of episodes of alternating hemiplegia, along with other therapeutic benefits.


Conservative follow-up after epidural abscess and diskitis complicating instrumented metal interbody cage.


Thrombo-embolic complication after streptokinase therapy of pulmonary emboli.


While peripheral neuropathy and cranial nerve involvement is common, optic neuropathy is extremely rare.


A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.


On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis.


CASE PRESENTATION: A 52-year-old-male was administered chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin for a Duke's stage C colorectal carcinoma.


Finally, the patient entered complete hematological and cytogenetic remission, although the PML-RAR alpha fusion product was still detectable by PCR.


She developed dark-red coloration on her hands, at the fourth day of treatment, which has been defined as fixed drug eruption.


The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.


Precautionary measures for the early recognition of this grave hazard in exposed patients are advocated.


OBJECTIVE: To describe two cases of rhabdomyolysis in patients taking lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin.


A 36-year-old patient with HIV developed a set of progressive left hemiparesis and secondarily generalized partial seizures related to progressive multifocal leukoencephalopathy.


The patient was extubated 24 h after her arrival to the ICU and discharged 72 h later.


Despite intensive hemodialysis and other supportive therapy, he developed multiple organ failure (liver, renal, and respiratory failure) and metabolic acidosis.


However, in addition to its antiviral activity, IFN is a pleiotropic cytokine able to synergistically amplify T-cell autoreactivity.


This case history, however, illustrates the susceptibility to these agents shown by some patients.


Similar to reports in patients receiving gefitinib, those with pathologic findings of UIP on resected lung specimens or known pulmonary fibrosis may be at particular risk for erlotinib pulmonary toxicity.


Fifteen months after surgical resection and adjuvant chemotherapy, the donor had no evidence of recurrent tumor.


After 1 week of nefazodone therapy the patient experienced headache, confusion, and "gray areas" in her vision, without abnormal ophthalmologic findings.


Anaphylactoid reaction to 50% solution of dextrose.


The rapid development of pulmonary aspergillosis associated with the formation of an Aspergillus mycetoma should be attributed to the loss of normal immune mechanisms due to immunosuppressive treatment.


BACKGROUND: Colchicine has a known adverse effect on wound healing through its inhibitory effect on tubulin-dependent cell functions and through collagenase activation.


FINDINGS: During this 3-year period, the Netherlands Pharmacovigilance Centre Lareb received 2522 reports directly from patients, concerning 5401 ADRs.


Among the serious systemic complications encountered were three instances of respiratory arrest and one of cardiorespiratory arrest.


[2] Anesthetized and intubated ferrets inhaled a placebo or VVR that was placed at the proximal end of the endotracheal tube.


Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension.


Topical provocation with ceftriaxone sodium salt (1% in water [aq.], 5% aq., 10% in petrolatum [pet.], 20% pet.) remained negative both at previously affected sites and in the unaffected skin of the back.


Most adverse events are due to an infusion-related symptom complex, and severe pulmonary complications are rare.


Treatment with isoniazid and ethambutol led to total recovery from pulmonary tuberculosis.


She subsequently had penetrating keratoplasty and lens extraction with IOL implantation in the right eye.


After abstinence from oolong tea his delirium resolved.


CONCLUSION: A patient with CHF and ESRD developed myoclonic muscle spasms after receiving dobutamine by continuous i.v. infusion.


In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.


Although this patient had been exposed to several other medications more commonly associated with TEN, his long-term tolerance of and uneventful rechallenge with these medications exclude them as potential catalysts to this drug reaction.


Malignant gliomas encompassing the eloquent areas cannot be removed totally and their surgical extirpation is followed by adjuvant therapy for the residual tumor.


This case reinforces the importance of considering infectious complications, such as those from endemic mycoses, in patients receiving treatment with a TNF-alpha antagonist and the importance of having a well-designed monitoring plan when subjects in a research study become ill.


Both children were treated with antibiotics and steroids.


The possibility that thiocyanate level in a newborn is unreliable as indicator of sodium nitroprusside overdosage is considered.


Thereafter LMWH was discontinued.


The five cases reported so far are reviewed.


Remission of psoriasis after treatment with interferon-alfa and 2-chlordeoxyadenosine for hairy cell leukemia.


Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.


CASE SUMMARY: A 66-year-old white woman with a 10-year history of hypertension and bronchial asthma was switched from immediate-release verapamil hydrocloride 40 mg tid to sustained-release verapamil 240 mg/d po for better hypertension control.


CASES: Sonograms were done within 24 hours after administration of thrombolytic agents at 15 and 26 weeks of gestation, respectively, in 2 women whose pregnancies were complicated with thrombosis of prosthetic mitral valves.


Serum myoglobin was over 3000 ng/mL.


He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.


The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.


Therefore, we gradually reduced the opiate dosage.


To our knowledge, no case of fatal agranulocytosis as a result of olanzapine treatment was reported in the literature.


Both patients developed a severe, sustained hypothyroidism requiring thyroxine treatment for one year or more after stopping alpha interferon.


B-CLL patients treated with fludarabine appear to be at risk for TA-GVHD and should be regarded as candidates for transfusions with irradiated blood products.


In patient 2, thrombolysis caused mobilisation of thrombotic mass as evidenced by disappearance of thrombus on ultrasound.


Pulmonary fibrosis is a complication of paclitaxel therapy that may occur despite treatments with corticosteroids.


After these were corrected the amphotericin B was restarted and the course of treatment completed successfully.


Soon after the third weekly session of the second protocol, the clinical status of the animal deteriorated suddenly and severely, with a bleeding tendency, jaundice, hyperuricaemia, hyperphosphataemia, azotaemia, hyperbilirubinaemia and, presumptive disseminated intravascular coagulation.


Both the psoriasis and the HCL cleared.


Estimated daily intake of propranolol in breast milk by the infant was about 3 micrograms.


His serum carbamazepine concentration was 3.9 microg/mL (reference range, 4-12 microg/mL), and his serum ammonia concentration was 127 microg/dL (reference range, 19-60 microg/dL).


His blood sugar became uncontrolled, he gained 13 pounds, and his A1c increased to 9.4%.


In each of the five patients, adenosine was given in a standard fashion (6 or 12 mg).


Contact dermatitis due to budesonide: report of five cases and review of the Japanese literature.


Blood cultures from the patient and from the plateletpheresis component were both positive for the presence of Streptococcus agalactiae.


Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.


Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.


The 2 children were discharged on days 13 and 16 and cytostatic therapy was restarted on days 18 and 25.


Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.


Second malignant neoplasm in childhood is increasing due to advances in therapy modalities.


In addition, he was given a continuous infusion of 400 micrograms daily human recombinant granulocyte macrophage-colony stimulating factor (rh GM-CSF) for 17 days.


Although given ephedrine, epinephrine, and atropine sulfate, the patient's normal heart rhythm could not be restored until calcium chloride was administered.


Unpredictable and potentially life-threatening, immune thrombocytopenia can occur with any drug, at times even after long, uneventful use.


In case #3, the concentrations of quetiapine found in femoral blood was 5.90 mg/L (15 micromol/L).


The current case demonstrates that some cystoid macular edema may not be responsive to vascular endothelial growth factor blockade alone.


Acute dystonia induced by lamivudine.


OBJECTIVE: To report three cases of bilateral Acanthamoeba keratitis in association with Synergeyes hybrid contact lens wear.


These two cases highlight the importance of considering lopinavir/ritonavir induced arrhythmias when dealing with HIV-positive individuals.


Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.


Magnetic resonance imaging (MRI) showed lesions suggestive of PRES.


Unfortunately, the patient died from adult respiratory distress syndrome.


Paralytic ileus in patients undergoing bortezomib treatment has been reported, although a definite attribution to bortezomib administration has not been established.


Microscopic sections from a biopsy at 12 h revealed epidermal necrosis, superficial ulceration, and a mild superficial and deep perivascular lymphoid infiltrate, associated with numerous thrombi of small vessels throughout the dermis.


Antidepressive treatment with fluoxetine 20 mg daily was initiated which was successful.


Though the acute complications of lithium toxicity involving the central nervous system have been known for more than 70 years, it is only recently that the longlasting sequelae of lithium intoxication have come to be discussed at length; about fifty-five cases have been reported so far.


Epithelioid angiosarcoma of the lung is a rare late complication of Lucite plombage treatment of pulmonary tuberculosis.


One individual who took crystalline niacin had beneficial effects on lipid levels, while the other person who took a delayed release preparation had little lipid effect.


Lenalidomide is an immunomodulatory agent approved for use in patients with myelodysplastic syndrome, and in combination with dexamethasone for refractory or relapsed multiple myeloma.


Indeed, the reported annual number of imported malaria cases increased to not less than 100.


Catheter directed thrombolysis has been described as a treatment for large pulmonary emboli resistant to systemic therapy [Kelly P, Carroll N, Grant C, Barrett C, Kocka V.


The diagnosis of hypothermia was delayed until it was apparent for several days but resolved with the discontinuation of risperidone and continuation of clozapine.


We report a case of a 72-year-old female who presented with hemoptysis, cough, and dyspnea.


Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).


Acute esmolol toxicity may be self-limiting because of its extremely short half-life.


The authors describe the use of milnacipran for the treatment of chronic pain in a series of patients.


Secondary hyperparathyroidism in certain patients with lithium nephrotoxicity is also possible.


Slit-lamp biomicroscopy and in vivo tandem scanning confocal microscopy were performed.


Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.


Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients.


The patient received an intravitreal injection of approximately 20 mg of triamcinolone acetonide.


After a six-week course of low-dose cyclosporine A, she developed a severe but reversible loss of glomerular filtration rate and effective renal plasma flow despite of low cyclosporine A plasma levels.


Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.


Lamotrigine toxicity secondary to sertraline.


To our knowledge , this is the first reported case of bromide intoxication due to pyridostigmine bromide administration.


Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder.


A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe.


Bradycardia and congestive heart failure associated with ocular timolol maleate.


The second patient experienced mild nitritoid symptoms following several GSTM injections prior experiencing a cerebrovascular accident within several hours of her next injection.


Accordingly, a practical and safe approach to MAOI dietary restrictions remains an essential component of patient management.


Pacemaker pocket infection due to acremonium species.


By the fifth day, a dramatic 7-fold increase was seen in the serum theophylline level (101.6 micromol/L [18.3 microg/mL]).


Examination showed a 7-cm mass and biopsy revealed angiosarcoma.


We report a patient diagnosed with B-CLL, previously treated with fludarabine, who developed TA-GVHD after being transfused during surgery for splenectomy.


This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.


Her serum electrolytes were sodium 122 mEq/L, potassium 5.9 mEq/L, chloride 93 mEq/L, and carbon dioxide 19 mEq/L.


A 62-year-old Caucasian man with atrial fibrillation who was taking warfarin reported an episode of hematochezia; his international normalized ratio (INR) was 1.74.


Pneumocystis carinii pneumonia as a complication of methotrexate treatment of asthma.