In both cases the etiology of the renal failure was not a direct result of the use of lithium.


Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.


Iatrogenic endometrial megapolyps in women with breast carcinoma.


She then was restabilized with warfarin.


Glutamine-supplemented tube feedings versus total parenteral nutrition in children receiving intensive chemotherapy.


Antiretroviral drugs may offer a better alternative to disfiguring surgery in the future.


Pseudomonas aeruginosa was the most common isolate and caused both CVC-related and CVC-unrelated infections, whereas other Pseudomonas spp. and Xanthomonas maltophilia were almost exclusively associated with CVC-related infections.


Cardiopulmonary resuscitation was successful after 45 minutes.


Bucillamine is used as an antirheumatic drug that is structurally analogous to D-penicillamine.


Positive inotropic support is routinely used for weaning from cardiopulmonary bypass circulation in patients with reduced left ventricular function.


Attempted treatment of factor H deficiency by liver transplantation.


The case history of an 11-year-old boy is reported.


Laboratory work-up was unrevealing.


While not proving safety, these data add to previous smaller series with similar findings, thus lending tenuous support to the use of this agent.


We recommend that a TMA in association with quinine be consistently referred to as quinine-associated thrombotic microangiopathy (quinine-TMA) to better distinguish this entity from idiopathic TTP.


One patient had a lower average heart rate and two patients had lower average mean blood pressure values during propranolol treatment, none of which was clinically significant.


Mycobacterium fortuitum is a rare cause of central nervous system infection; however, shunt infection caused by this organism has not been reported.


We conclude that etanercept may be a safe and effective therapy not only in severe psoriatic arthritis, but also in cases of pustular rebound after withdrawal of immunosuppressive agents.


Lithium treatment of a patient with periodic catatonia.


CONCLUSIONS: This case series describes a clinically distinct form of interface inflammation that presents late and is associated with elevated intraocular pressure.


Given this case report, we recommend close monitoring of women using this herbal preparation.


Pathophysiologic concerns have also been a key reason why physicians have avoided using beta-blockers in patients with diabetes.


Autopsy revealed diffuse vasculitis involving the heart, lungs, kidneys, testes, spleen, liver, skin, gut wall and marrow with neuritis of gut wall nerves and ganglia.


During her third cycle, she again received cisplatin 100 mg/m2 over 30 minutes and developed palmar pruritus, urticaria, and edema.


For the most part these preparations have been considered safe.


Destructive thyrotoxicosis appeared 4-6 months after starting IFN-alpha, followed by Graves' hyperthyroidism within 8 to 11 months.


The incidence of 5-fluorouracil (5-FU)-related cardiotoxicity seems to be dosage and schedule dependent.


Depressive symptoms got worse and electroconvulsive therapy was tried.


Again, a similar set of symptoms as seen initially were noted, along with an elevation of the serum CPK level.


She was apparently well after drinking the first of two bowls of 'maqianzi' decoction.


Nocardiosis. A literature review with selected case reports in two dogs.


Left main coronary artery stenosis treatment with two paclitaxel-eluting stents in a patient with cardiac allograft vasculopathy.


Electron microscopy showed diffuse effacement of the glomerular epithelial foot processes, leading to a diagnosis of minimal change nephrotic syndrome with interstitial nephritis.


Although various manifestations of pentamidine-induced cardiotoxicity have been reported, to our knowledge, second-degree heart block associated with this agent has not been described.


Hysteria scores on the MMPI were found to be related significantly to self-reported effects under both the drug and placebo conditions.


Neutropenic enterocolitis should be considered in patients with abdominal symptoms especially during the granulocyte nadir following chemotherapy.


Physicians should keep in mind that taxanes such as paclitaxel have the potential to cause pneumonitis and lung fibrosis.


Severe leukopenia associated with mild hepatotoxicity in an HIV carrier treated with nevirapine.


After the patient developed recurrent infections, laboratory findings disclosed panhypogammaglobulinaemia with B-lymphocyte deficiency.


The effects of these drugs on the dentition such as tooth decay and erosion have been a subject of debate among dental practitioners.


By light and electron microscopic appearances the renal lesion was an epimembranous deposit form of membranous glomerulopathy.


We report the occurrence of delayed postoperative coma in five of nine consecutive children following surgery for insertion of baclofen infusion pumps.


A 34-year-old male with lumbar disc disease and surgery was placed on gabapentin daily for chronic back pain.


On further investigation, coronary angiography revealed a long chronic dissection of the right coronary artery.


She underwent a standard protocol for insulin desensitization twice in a 2-month period, with persistence in her symptoms.


Ketorolac in reflex sympathetic dystrophy.


In a 61-year-old man receiving chronic low-dosage amiodarone an interstitial pneumopathy was observed.


Infection of a shunt by Mycobacterium fortuitum: case report.


An unusual presentation of spontaneous sub-conjunctival haematoma in a patient receiving warfarin.


The patients' median age was 21.5 years (range 16 to 53 years) with a median SAPS II of 14 (range 12 to 84) and an APACHE II of 8 (range 6 to 36).


Its treatment is mainly based upon discontinuation of heparin therapy.


Both patients presented as self-referrals to the emergency department.


The two cases occurred on days 2 and 3 post-BMT, respectively.


The patient was then submitted to three sections of 1,600 mg/m2 of gemcitabine with intervals of 1 week.


The aim of this study is to evaluate steroid therapy effect in patient treated for eosinophilic jejunitis to share our experience with other colleagues.


The serumcholinesterase activity of the patient's serum increased by 55% (from 15% to 70%) following the injection.


Cicatricial entropion associated with chronic dipivefrin application.


In 1984, a 56-year-old house painter developed intractable pain in his back and other joints.


This illustrates intravenous pamidronate as a valuable therapeutic tool when milk-alkali syndrome presents as hypercalcemic emergency.


We describe a patient who developed HUS after treatment with mitomycin C (total dose 144 mg/m2) due to a carcinoma of the ascending colon.


Thrombosis of the left main coronary artery following percutaneous transluminal coronary angioplasty.


This was accepted as evidence for propranolol being the cause of this conduction disorder.


The disease is suggested endoscopically by its typical appearance.


BACKGROUND: Headaches have been reported as a potential side effect of capecitabine therapy.


CONCLUSIONS: Adrenal suppression after steroid injection for periocular capillary hemangioma is a potentially life-threatening complication.


She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobramycin trough level 1 week before the onset of tetany.


Stenoses in the left coronary artery were verified angiographically.


This is one of the few cases of drug-induced LAD in which the target antigen profile has been characterized, and the first in which the antigen has been shown to correspond to collagen VII.


Despite discontinuance of the drug and/or institution of corticosteroid therapy, progressive respiratory failure led to death.


Treatment of Parkinson's disease should be determined by level of disability and handicap.


The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.


Overall, the features are protean and may masquerade many other forms of toxaemias.


Sudden onset of erythroderma gave rise to a temporary arrest of the function of nail matrix with the resultant Beau's lines.


We report two cases of secondary AML in which platinum compounds were the sole prior chemotherapy.


However, this reversible, probably drug-induced case of hypogammaglobulinaemia highlights the need for immunoglobulin measurements when immunodeficiency is suspected in lupus patients.


After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.


Muscle biopsy revealed fibrous myopathy.


Calciphylaxis is a rare, life-threatening cause of skin necrosis.


After immediate treatment with low molecular weight heparin (enoxaparin), the thrombus improved without any additional complications.


We describe t(8;16)(p11;p13) acute myeloid leukaemia (AML-M4) in a 12-year-old white male with a history of prenatal X-ray exposure.


Based on plasma TCA concentrations in our patient, we calculated a terminal half-life of TCA of 33 days as opposed to 5 days observed after intra-articular administration of a therapeutic dose of 40 mg TCA.


Excessive bleeding is a major concern during the administration of thrombolytic therapy.


The clinical response was reflected by an increase in circulating interleukin (IL) 10 and a decrease in IL-6 and IL-8 serum levels during treatment.


Past medical history was significant for hepatitis C and bipolar disorder.


In two of the cases, the patients had documented histories of vascular disease, which their internists had identified as the cause of their impotence.


The next day, he suffered from a paralytic ileus.


Atypical CD8+ cutaneous T-cell lymphoma after immunomodulatory therapy.


The KS cases associated with glomerulonephritis are also reviewed.


In a postoperative patient with pre-existent myasthenia gravis, oral verapamil caused a marked exacerbation in myasthenic weakness.


However, in ill and/or young children, behavioral audiometry may not be sufficiently precise to detect the early stages of hearing loss.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


Patients who have received total parenteral nutrition (TPN) without proper replacement of thiamine have also developed WE.


This article discusses the initial treatment attempted at resolving the bronchospasm, as well as the use of heliox in the ultimate resolution of the bronchospasm.


We report a case of acute generalized exanthematous pustulosis (AGEP) in a 50-year-old woman that was attributed to the ingestion of nimesulide.


BACKGROUND: Hypersensitivity reactions to cyclosporine are rare.


A 78-year-old woman with many medical problems, including chronic obstructive pulmonary disease, was treated with parenteral levofloxacin for community-acquired pneumonia.


In a female with acute lymphoblastic leukemia, inadvertent doxorubicin administration intrathecally caused severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus.


Regardless of a negative history of asthma, therefore, life-threatening bronchospasm must be considered a possible complication of propranolol therapy.


An acquired form of sideroblastic anemia has been described in association with several drugs, especially anti-microbial agents.


The role of Adriamycin in the production of cardiotoxicity is reviewed.


DISCUSSION: Back pain, with or without opioid dependence, is commonly encountered in general practice.


Treatment brought about a decrease in the extent and depth of osteoid, but matrix abnormalities remained.


This regimen was well tolerated, although both children were critically ill.


CONCLUSION: ECT with muscle relaxants could be administered safely, with appropriate precautions kept in mind.


Erosive oral lichen planus (OLP) is a painful chronic inflammatory disease that is sometimes resistant to systemic or topical therapies.


The patient had insertion of the levonorgestrel-releasing intrauterine system (LNG-IUS).


After irradiation of only the right eye, the rats were followed for several months in an attempt to determine the effects of estrogen on radiation cataractogenesis and investigate potential strain differences in this phenomenon.


A CT scan revealed an abdominopelvic abscess encompassing the detached catheter which embedded in the rectosigmoid colon, allowing direct communication to the upper vagina.


There was one reported death.


Biopsy specimens of the upper tarsal conjunctiva in soft contact lens-associated giant papillary conjunctivitis were taken during (1) chronic exacerbation, (2) brief remission, and (3) intentional exacerbation.


He developed hypertension in April 1989, underwent a final chelation, and retired.


Recurrent prosthetic hip infections, particularly in immunosuppressive patients, should alert the physician to consider the possibility of both tuberculous and atypical mycobacterial infections.


Progressive paraplegia, one of the devastating neurologic complications related to this mode of treatment, has been attributed to spinal cord toxicity.


Although there was evidence of spread of the S typhimurium in the community, there was no evidence of spread of this Salmonella R plasmid to the normal flora of patients or their family members a median of 14 weeks after the infection.


He had previously received both local tumor bed and craniospinal radiation therapy together with intensive myeloablative alkylator chemotherapy before autologous stem cell rescue.


Interestingly, the majority of cases after OHSS involve thrombosis of the upper extremities.


We report on a case of localized ganglioneuroblastoma treated by carboplatin/etoposide for 2 courses and surgery, which developed a serious GHD after 56 months.


During that time, he had also been taking amphetamine-dextroamphetamine (Adderall) on work days for his ADHD.


We present the case of a 52-year-old white male who showed arthritis, conjunctivitis and non-gonococcal urethritis.


After 14 days of anticoagulant therapy with UFH, the regimen was changed to low molecular weight heparin (LMWH; Fraxiparin 0.3; 2850 IU anti-X activity/d s.c.; bw 60 kg).


He was hyperthermic (oral temperature 40.6 degrees C), diaphoretic, tachycardic (heart rate 140 beats/min), and tachypneic (respiratory rate 22 breaths/min), with severe muscle rigidity and shaking tremors.


Toxic symptoms (sinus arrest) reappeared twice and were accompanied by increasing amounts of non-antibody-bound DGTX in the serum.


We followed bone marrow morphology in a 2-year-old male with HS who received up to 8 micrograms/kg GM-CSF per day because of failure of allogeneic bone marrow engraftment.


Shortly after chemotherapy and an injection of pegfilgrastim, the patient developed poorly defined, rapidly progressive erythema, edema, and pain in his right forearm.


Elective surgery days after myocardial infarction: clinical and ethical considerations.


CONCLUSION: We believe this observed rate of serious infection is acceptable in the context of optimally treating active RA.


The intralesional injection of corticosteroids has been employed successfully in treatment of adnexal neonatal hemangiomas since 1979.


The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.


We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.


We have recently encountered a patient with acquired haemophilia who developed a thrombotic left middle cerebral artery distribution stroke while being treated with pFVIII.


Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.


He had been receiving L-thyroxine therapy following mitral valve surgery.


Oral corticosteroids are the main therapeutic choice for systemic lupus erythematosus (SLE).


Emphasis is given to the differentiation of diphenylhydantoin induced gingival hyperplasia from the angiomatous enlargement of the gingiva before any treatment is planned.


Osteonecrosis in patients with testicular tumours treated with chemotherapy.


One woman received ifosfamide 1000 mg/m2 (1 h infusion on days 1-5); confusion, lethargy, and speech deterioration developed on day 3.


Transplant recipients are at highest risk during the first 3 months posttransplant.


Initially, antipsychotics and especially pimozide were considered to be the pharmacological approach of choice but, subsequently, tryciclic anti-depressants and selective serotonin re-uptake inhibitors (SSRIs) were also suggested to be effective, implicating the serotonergic system in the pathophysiology of the disorder.


Iatrogenic central retinal vein occlusion and hyperviscosity associated with high-dose intravenous immunoglobulin administration.


We describe the case of a 36 year old patient who was admitted to the intensive care unit (ICU) for an acute asthma attack that failed to respond to conventional treatment and required mechanical ventilation.


In this study, we present a 75-year-old woman who had five children.


Two patients developed diabetic coma when taking a combination of a thiazide diuretic and propranolol.


Henna is a traditional cosmetic agent and is used worldwide.


Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C.


This cause of bleeding could not be brought under control endoscopically.


On January 29, the patient began having myoclonic muscle spasms.


She had multiple orthopedic interventions for kidney-related osteoarticular problems probably favored by the kidney graft and the immunosuppressive treatment.


We report a case of severe anemia, which responded well to steroid therapy, in a patient receiving IL-2 plus IFN-alpha for metastatic renal cell carcinoma.


On patch testing, budesonide was strongly positive at day 2 and 3 in a concentration ranging from 1% to 10 p.p.m. (in petrolatum).


Recent trends in the diagnosis and management of typhilitis or neutropenic enterocolitis have been reviewed.


HIT is an immune-mediated adverse drug reaction that may be associated with limb or life-threatening thrombosis.


Fortunately, however, the hepatotoxicity appears to resolve after discontinuation of the TMP-SMX therapy in most reported cases.


Venlafaxine, a structurally novel antidepressant, belongs to a new generation of antidepressants--the serotonin/noradrenaline reuptake inhibitors.


Report of a fatal case.


Imidazoline intoxication in children.


An extensive workup for other causes of eosinophilic pleural effusion was unrevealing.


The patient's score on the Naranjo adverse drug reaction probability scale indicated that the relationship between this adverse reaction and heparin was probable.


After development of the tics in 2, CBZ was continued at the same or higher dose, and the tics abated and then ceased spontaneously < or = 6 months.


A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).


His extensive cytotoxic chemotherapy for AML is reviewed along with a discussion of its possible oncogenic effects.


Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction.


Therefore, it is advisable to consider early glucocerebrosidase replacement therapy in GD patients receiving cytotoxic or targeted therapy for cancer.


The patient was started on low molecular weight heparin, which resulted in resolution of her clinical condition.


An otolaryngology consultant performed fiberoptic laryngoscopy and paradoxical vocal cord movement was diagnosed.


Spontaneous recovery accompanied a reduction in steroid treatment to a low level.


We present three clinical cases of clostridial orthopedic infection and review the related medical literature.


The clinical picture was a severe alveolitis, with compromised gas exchange.


Hypersensitivity to carboplatin is a rare but real complication of therapy and should be considered in patients presenting with hyperacute changes on ECG whilst receiving carboplatin therapy.


Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.


A clinical history was taken, and laboratory and imaging tests were performed.


A 72-year-old woman with a history of thyrotoxicosis presented with sore throat and fever two weeks after starting carbimazole.


Abnormal air accumulation was noted in the bowel, peritoneum, mediastinum and retroperitoneum.


Its treatment consists of corticosteroids and/or other immunosuppressive drug such as azathioprine, vincristine, cyclosporine, and mycophenolate mofetil.


Autoimmune thyroid disease is a common side-effect of interferon-alpha (IFN-alpha) treatment of viral hepatitis C.


The patient underwent a successive surgical procedure without any adverse event.


We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide.


Nephrotic syndrome related to systemic lupus erythematosus after griseofulvin therapy.


INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued.


This appearance should be considered as a possible false positive in patients undergoing such treatment who are being investigated with PET scans.


The profile of catecholamine metabolites changed: on day 150 of therapy, noradrenaline, adrenaline, and dopamine levels were increased, whereas HVA and VMA levels were decreased when compared to day 1 of therapy.


The bupivacaine concentration was reduced in a stepwise fashion from 0.5% to 0.25% and was changed to levobupivacaine after 3 days.


The administration of "sweet spirits of nitre" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.


The first reported case, in an adult, of cholestyramine induced hyperchloremic metabolic acidosis is a 70 year old female with a two year history of primary biliary cirrhosis confirmed by histologic and immunologic criteria.


The preliminary results (after 2 to 9 months of therapy) show 5 patients (24 per cent) did not benefit from the drug and 7 patients (33 per cent) are stable.


However, there can be a delay in diagnosing porphyria and a difficulty in selecting safe medicine for it even today.


However, 35% of the case reports involve patients with other illnesses, including 12 patients who did not have neoplasms.


Nonexcisional approaches include topical imiquimod, and curette and cryotherapy (C&C).


None of these patients had cystic or other significant macular changes.


Pure red cell aplasia after ABO-incompatible allogeneic stem cell transplantation in severe aplastic anemia with response to steroids: a case report and literature review.


The patient recovered with intensive supportive management including broad-spectrum antibiotics, bowel rest with gastric intubation and intravenous gamma-globulin.


This article reports the orthodontic treatment of 2 patients who were taking bisphosphonates.


A typical regimen is cytarabine 3 g/m2 iv over one to three hours q 12h for a total of 8 to 12 doses.


Astute nursing care is essential to prevent complications associated with this procedure.


Vacuolar myelinopathy of the brain and lamellar ichthyosis.


The next morning the woman was improved and informed clinicians of her desmopressin use.


Extrapyramidal syndrome presenting as dysphagia: a case report.


The diffuse gastritis was aggressively treated with proton pump inhibitors.


Initial single rinsing with phosphate does not produce corneal calcification (P=0.134).


Three girls, two aged 12 years and one aged 17 years with refractory localization-related epilepsy were treated on an add-on basis with tiagabine.


We describe the development of cutaneous scleroderma in 3 patients coincident with the use of bleomycin in low cumulative doses of less than 100 U.


CONCLUSIONS: Given the fulminant course of amphotericin B deoxycholate overdosage and lack of effective therapy, stringent safeguards against its improper administration should be in place.


A child with respiratory distress was found to have been given an antibiotic which was reconstituted with methadone.


Patients with HIV disease have a significantly higher prevalence of QTc prolongation than a general hospital-based population, may have an unrecognized acquired form of the long QT syndrome, and are at risk for torsades de pointes.


Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.


Rebound hyperglycemia was observed with both intermediate (neutral protamine hagedorn) and long-acting (protamine zinc iletin) insulins, and the range of insulin doses at which the disorder developed overlapped previously determined therapeutic doses for these insulins in the cat.


A complication of short-term systemic corticosteroid use.


Depression is an extremely common illness in the elderly, and is, at times, refractory to the usual therapies.


Anticoagulant therapy was initiated with subcutaneous enoxaparin and oral warfarin.


In one instance a systemic hypoglycemic reaction resulting in head trauma and confusion ended in an emegency hospital admission following the substitution of acetohexamide for acetazolamide.


The response of the occlusion of nearly all liver venules underlines the value of anti-inflammatory treatment combined with new thrombolytic medication such as defibrotide for the treatment of severe VOD.


The adrenaline concentration in the left femoral vein was twice as high compared to the right femoral vein.


The literature search found 12 cases of radiation recall caused by gemcitabine.


CONTEXT: Previous investigators have reported discrepancies between hematologic, marrow morphologic, and cytogenetic responses to imatinib mesylate among patients with chronic myeloid leukemia (CML).


After these 5 weeks of dosage increases, the INR became supratherapeutic for 3 weeks, resulting in a subsequent dosage decrease.


The cyclophosphamide (1 g/m(2) per day) and thiotepa (80 mg/m(2) per day) doses were based on body surface area (BSA) calculated using total body weight (TBW).


Long-term posaconazole treatment and follow-up of rhino-orbital-cerebral mucormycosis in a diabetic girl.


Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.


He presented with arthralgias, uveitis and respiratory insufficiency and developed hyperuricemic renal failure upon institution of treatment.


It is known to cause coagulation abnormalities, thrombosis and hemorrhage in the central nervous system in addition to vasculitis and hypersensitivity reactions.


Drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS) is a severe multiorgan reaction with reactivation of herpesviruses.


CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.


Two prior episodes of visual loss had occurred during oral contraceptive treatment, an association not heretofore reported.


Clinically, the patient appeared cushingoid with a buffalo hump, thin skin, bruises, and purple striae, and his blood pressure was 130/90 mm Hg.


Surprisingly, we found that three patients appeared to develop tardive OGC while taking clozapine.


PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.


Naltrexone: report of lack of hepatotoxicity in acute viral hepatitis, with a review of the literature.


She received 600 mEq of sodium bicarbonate intravenously over 36 hours by which time her mentation, electrolytes and pH were normal.


However, graft function could not be restored.


Human chorionic gonadotrophin, administered exogenously as well as produced endogenously during pregnancy, is responsible for the onset of OHSS, and high levels of estradiol appear to worsen the condition.


Avascular necrosis of the femoral head in patients with prostate cancer treated with cyproterone acetate and radiotherapy.


Antivenin reactions developed in three.


This case report describes a patient who developed a seizure with single-pulse transcranial magnetic stimulation during motor threshold estimation.


Microbiologic evaluation is essential for accurate early diagnosis and treatment.


Serious infection during neutropenia was the most common complication.


During this period, urine losses of monovalent cation were only 55 mEq and body weight was constant at 48.2 kg.


Sunitinib is an orally administered multitargeted tyrosine kinase inhibitor that has demonstrated substantial antitumour activity in patients with metastatic renal cell carcinoma.


This regime was well tolerated and we report dramatic resolution of the lesions with persistent clearance 6 months after completion of the fifth infusion.


Such a case induced by hypothyroidism complicating long-term therapy with amiodarone in a 45 year old woman with pre-excitation is presented.


CONCLUSIONS: A subgroup of patients with idiopathic sensorineural hearing loss (SNHL) will have steroid-dependent symptoms which can be confirmed using pure-tone audiometry.


All three patients had to have treatment discontinued because of side effects, in part contributed to by preexisting medical problems, appeared.


Gaucher's disease (GD) is an autosomal recessive lysosomal storage disease resulting in an abnormal accumulation of glucocerebrosides in macrophages.


Treatment of mycosis fungoides with topical nitrosourea compounds: Further studies.


Dramatic clinical improvement occurred in 2 patients treated with high dose steroids.


Disseminated cellulitic cryptococcosis in the setting of prednisone monotherapy for pemphigus vulgaris.


The most common presenting symptoms and signs were confusion, agitation, diaphoresis, tachycardia, myoclonus, and hyperreflexia.


Case 1, a 62-year-old woman, developed bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities after a seven-month use of recombinant interferon alpha-2a for chronic active hepatitis C.


DATA SYNTHESIS: The first case describes a 15-year-old boy who received valproic acid and carbamazepine for partial seizures.


Pantavalent antimony can cause a wide range of adverse effects, the most serious of which are cardiotoxicity and hepatotoxicity.


Piritrexim-induced pulmonary toxicity.


No cerebral lesion was detected.


We report a 14-year-old boy with high risk medulloblastoma treated with craniospinal radiation followed by chemotherapy, who experienced severe HSOS after only one course of chemotherapy including carboplatin, vincristine, and cyclophosphamide.


Hepato-biliary abnormalities secondary to ceftriaxone use: a case report.


Interstitial pneumonitis and alveolar hemorrhage complicating use of rituximab: case report and review of the literature.


Common adverse events (frequency 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence).


Medulloblastoma in a patient successfully treated for immature teratoma of the ovary.


The authors describe 4 cases of patients with bifurcation lesions involving the left anterior descending coronary artery, who developed periprocedural thrombosis with acute transmural ischemia.


A unique case of a transient, nonpigmenting fixed drug eruption caused by the radiopaque contrast medium iothalamate is reported.


We describe the case of a girl with APECED, who presented with four endocrine (hypoparathyroidism, Addison's disease, hypothyroidism, gonadal failure) and three non-endocrine components (candidiasis, ectodermal dystrophy and lichen ruber planus).


In three of the patients drug kinetic investigations were performed and revealed a slow metabolizer status.


Rejection of blood transfusions by individuals of this faith is usually blamed to justify this attitude, thus leading to severe personal, medical and psychological distress related to the lack of care.


Acute non-lymphocytic leukemia occurred in eight women following long-term treatment with Treosulfan (= dihydroxybusulfan) for ovarian carcinoma.


Donepezil therapy was discontinued prematurely in three of the cases due to insufficient response and/or adverse events.


Ventricular systolic function recovered completely by the fourth hospital day.


Quinapril is an angiotensin-converting enzyme inhibitor (ACE-inhibitor) and overdose can lead to prolonged hypotension and, less frequently, transient renal impairment.


The other two patients developed immune-related adverse events (irAEs) including rash (one case; grade 2) and diarrhoea (both cases; grades 1 and 2, respectively); the histopathology of colon biopsy samples from both was suggestive of colitis, with an abundant CD8+ T-cell infiltrate.


DISCUSSION: After exclusion of other causes, the onset of thrombocytopenia after administration of lansoprazole, the resolution of the adverse reaction after discontinuation of the drug, and the fact that no other medicines were introduced during this time frame lead us to believe that this was most likely an idiosyncratic thrombocytopenic response to lansoprazole.


Treatment with methoxsalen and UV-A radiation successfully cleared the photosensitive eruption in the patients.


Adriamycin-induced cardiomyopathy aggravated by cis-platinum nephrotoxicity requiring dialysis.


Interferon-alpha affects the immune response in post-transplant lymphoproliferative disorder.


Transarterial membranotomy and repeated infusion of thrombolytic agents and anticoagulants directly in the thrombus brought about improvement of the circulation surrounding the liver and IVC, and recovery from hepatic failure.


The eruption in this case may have been an allergic reaction arising in a depressed immunity induced by chemotherapy.


Severe rash, including the Stevens-Johnson syndrome (SJS), is the major toxicity of nevirapine and is described in the package labeling with a prominent, boxed warning.


Clinico-pathological correlations were made.


Only three cases have been described in the literature.


We report the case of a patient suspected of voluntary massive poisoning by ethylene glycol.


The pharmacology of the drug and therapeutic experiences in 6 cases are described.


OBJECTIVE: The aim of this paper is to describe a case of increased libido during fluvoxamine therapy.


We report on a patient in whom a giant thrombus in the left atrium was detected by transthoracic echocardiography.


From these experiences panic anxiety seemed to be a withdrawal symptom, and involvement of the noradrenergic system in panic anxiety as well as serotonergic system was suggested.


The diagnosis was initially thought to be a recurrence of idiopathic thrombocytopenic purpura (ITP) that had initially occurred in 1992 and had required splenectomy.


A case of pseudotumor cerebri following glucocorticoid therapy in which warfarin prevented recurrence.


Bosentan and warfarin interaction.


The rarity of severe complications in this situation warrants presentation of the following unique association.


Its use is considered to be less harmful than the effect of active disease on the fetus.


We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion.


Using micro broth dilution technique the isolated strain was shown to be most susceptible to penicillin G, cephalothin, and ciprofloxacin, with minimal inhibitory concentrations of 0.00025, 0.004, and 0.002 mg/l, respectively; and with minimal bactericidal concentrations (99.9% killing) of 0.25, 0.12, and 0.008 mg/l, respectively.


BACKGROUND CONTEXT: Spontaneous spinal epidural hematoma (SSEH) is an infrequent spinal pathology.


The incidence of 5-fluorouracil (5-FU)-related cardiotoxicity seems to be dosage and schedule dependent.


This patient's experience stresses the need to consider beta-blockers as a potentially reversible cause of memory impairment.


Subsequent in vivo/vitro studies clearly demonstrated that the neurological effects were due to a synergistic action of desferrioxamine and prochlorperazine, probably resulting in exceptional fluxes of intra/extra cellular iron/copper disturbing noradrenergic and serotonergic systems.


The purpose of this work is to report the case of oral chemical burns caused by topical self-medication for tooth pain relief, and also to discuss the clinical presentation and the treatment performed.


During four courses of chemotherapy for a disseminated testicular seminoma a 30-year-old man developed three arterial occlusive events and one silent myocardial infarction.


Most cases are due to Candida spp. while Aspergillus spp. and zygomycetes have only rarely been implicated.


Three cases of self-inflicted gingival injuries resulting from the improper use of the Keyes technique are presented.


Treatment of periocular capillary hemangioma with topical clobetasol propionate.


We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.


Two adverse effects were reported: 1 case of reversible urinary retention and 1 case of deficiency of the dorsiflexor muscles of the foot.


G-CSF was successful in producing a rise in neutrophil count which coincided with a resolution of fever; there was no adverse effect on renal function.


The use of sulfonylurea medications in the treatment of type 2 diabetes mellitus is common.


He recovered successfully after treatment with very high doses of corticosteroids and azathioprine.


Latero-lateral anastomosis between the common bile duct and duodenum was performed during explorative laparotomy and ursodeoxycholic acid treatment was introduced.


A systematic investigation ruled out causes of physiological and reactive thrombocytoses.


DISCUSSION: The Naranjo probability scale indicated a probable relationship between sertraline treatment and the onset of rhabdomyolysis.


We present a case of documented N. sicca peritonitis immediately following an episode of Staphylococcus aureus peritonitis in a pediatric chronic peritoneal dialysis (CPD) patient.


Thirty months after the start of chemotherapy, preleukemic changes were observed in peripheral blood and bone marrow, and acute nonlymphocytic leukaemia (M5 of the FAB classification) was diagnosed shortly afterwards.


Reversal of ergotamine-induced arteriospasm by mechanical intra-arterial dilatation.


We suggest being aware of such reactions during omeprazole usage.


Both patients (27 wk, 5 d; and 26 wk, 6 d of gestation) underwent surgical arterial duct ligation and coarctation repair.


The final pathologic examination confirmed high-grade leiomyosarcoma.


Our patient presented at the emergency department with an increasing scalp swelling for 2 weeks, and culture of the evacuated fluid yielded Streptococcus pneumoniae.


The purpose of this paper is to illustrate a retrospective case report demonstrating drug extravasation caused by the development of fibrin sheath formation.


Caution is emphasized in the use of carbonic anhydrase inhibitors in patients with obstructive airway disease.


Possible linkage of amprenavir with intracranial bleeding in an HIV-infected hemophiliac.


This regimen should decrease the risk of antibiotic induced nephrotoxicity, but it requires further study.


Medical management of the head and neck cancer patient (HNCP) most often will include radiation therapy to the head and neck region.


In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.


The drug was immediately withdrawn and the patient was given glibenclamide.


Blood pressures continued to increase, however, and late postpartum eclampsia developed.


Methotrexate is an effective but potentially toxic treatment for psoriasis.


Erythromycin is a macrolide antibiotic that may increase the risk of lovastatin-induced rhabdomyolysis.


We describe a case of interstitial hypoxaemiant pneumonitis probably related to flecainide in a patient with the LEOPARD syndrome, a rare congenital disorder.


We recommend the cautious use of alum irrigation in patients with renal impairment and monitoring of serum aluminum levels to prevent excessive accumulation and toxicity.


METHODS: A 40-year-old patient developed painless corneal edema despite minimal epithelial injury after exposure to ushaar latex.


The most common chemotherapeutic agents implicated are anthracyclines and taxanes.


The patient described feeling cold with worsening headache and chills approximately one hour after infusion of the first dose of penicillin.


Intranasal desmopressin-induced hyponatremia.


When measured, the serum lithium level had increased 4-fold during acyclovir therapy.


Steroids also contributed to the improvement of the nephrotic syndrome and proteinuria decreased from maximal ranges of 27 g/l to 2.2 g/l after six months of the follow-up.


The thyroid gland was not enlarged or tender.


Since July 1985, 23 patients have been entered into a phase I/II clinical trial using intraarterial 5-bromodeoxyuridine (BUdR) (400-600 mg/m2 daily for 8.5 weeks) and focal external beam radiotherapy (59.4 Gy at 1.8 Gy daily in 6.5 weeks) in the treatment of malignant gliomas (Kernohan grades 3 and 4).


Two cases of lepromatous leprosy with erythema nodosum leprosum who were on high doses of clofazimine, showed discoloration of nail plate, subungual hyperkeratosis and onycholysis.


Following intravenous hydration and administration of bicarbonate, the patients' condition resolved without permanent' sequelae.


In the following case report, a patient developed acute interstitial nephritis with renal failure and exfoliative dermatitis following ampicillin therapy.


Ptosis occurring 24 h after chloroquine therapy, with full recovery 48 h after cessation of chloroquine, has not been described previously.


Before invasive procedures are performed, thought must be given to what changes in treatment may be made when results are known.


Generalised cutaneous rash associated with ganciclovir therapy has rarely been reported in literature.


Acute renal failure caused by fungal bezoar: a late complication of Candida sepsis associated with central catheterization.


In this report, we describe a novel presentation of interface inflammation that resembles DLK in appearance but presents late in the postoperative period, is associated with increased intraocular pressure, and is exacerbated by steroid treatment.


We discuss the possible causes of stroke.


Carcinoma arising in the pleural cavity following pneumonectomy for hydatid disease.


Hemoglobin levels normalized after administration of enalapril was stopped.


Because of its selective action on B lymphocytes, it is considered a moderate immunosuppressant in terms of infection.


Right internal carotid artery occlusion during intravenous thrombolysis for left middle cerebral artery occlusion.


When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.


Four of the patients reported erectile dysfunction before beginning apomorphine and two of these report a significant improvement in their sexual function resulting from apomorphine use.


Shewanella spp. infection following treatment for upper gastrointestinal bleeding.


Our report points out differences between acute, postacute, and longterm rehabilitation, describes the mobilization of patients in acute rheumatology units, and defines specific problems encountered in acute hospital-based rehabilitation of rheumatological patients.


Attempts at anticoagulation with oral warfarin were unsuccessful while the patient was receiving 50-100 ml/hr of Osmolite through an Entriflex feeding tube and intermittent oral Ensure Plus supplements.


While exclusion of any bacterial infection and screening for tuberculosis are mandatory before initiating a therapy with anti-TNF-alpha-antibodies, there are no guidelines whether to screen for or how to deal with chronic viral infections such as hepatitis B.


Systemic allergic reactions to aprotinin injection around the Achilles tendon.


Because of the difficulty of case collection, understanding of the association of MAHA and anal squamous cell carcinoma remains vague.


There was no correlation between onset of symptoms and CyA levels.


His thigh was indeed in close contact with his trousers pocket where he used to store a wiping rag drenched into white spirit and cellulosic thinner.


Treatment of ELP in children is generally supportive, with the symptoms and roentgenographic abnormalities resolving within months after stopping the use of mineral oil.


I report a 35-year-old woman with occult coronary artery disease who experienced cardiac arrest within minutes after receiving a first-time dose of subcutaneous sumatriptan for migraine.


Although tardive dyskinesia is a known adverse reaction of sustained treatment with traditional neuroleptic agents, it was only rarely reported in association with sulpiride, a selective D2-receptor antagonist.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


Four of these were derived from a study of 100 schizophrenic patients on maintenance neuroleptic medication, thereby giving a prevalence of 4% in such patients.


Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.


Digestive hemorrhage caused by a Meckel's diverticulum in a metformin-treated patient: is there any connection?


Nucleotide sequence of the UL54 and UL97 of the clinical isolate showed 4 amino acid substitutions (V11L, Q578H, S655L, and G874R) in UL54 and 2 mutations (A140V and A594V) in UL97 compared with the Towne and AD169 strains.


One patient improved after withdrawal of dextroamphetamine; others had worsening of their symptoms on higher doses of medications.


The evidence from this series of cases and from six additional cases identified in the literature suggests that the risk of endometrial sarcomas may be increased by estrogen therapy or endogenous disorders that lead to unopposed estrogenic stimulation of the uterus.


Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as "red man syndrome" and anaphylaxis.


Indicators suggesting review by appropriate medical personnel for possible clonazepam behavioral side effects are provided.


It is tempting to speculate that interferon alpha may be involved in the pathogenesis of lichen nitidus.


This article reports the impact of inadvertent acyclovir exposure on a woman during the first trimester of pregnancy and reviews the literature on acyclovir's pharmacology, safety profile, and potential uses during pregnancy.


This case illustrated the importance of early diagnosis of sympathetically mediated chest pain and role of Stellate ganglion block.


When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.


The "pinch-off sign" was noted on a routine chest X-ray but that was ignored.


Surgical resection, when possible, and prolonged treatment with amphotericin provide the most effective form of therapy.


Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation.


Clinical examinations and slit-lamp photographs, over an average of 21.3 +/- 7.2 months (range, 11 to 31 months), documented the effects of different treatment modalities.


The discolouration resolved when the creams were ceased.


Subsequent progression of cataract required cataract extraction, which resulted in a very rapid progression of the exudative macular degeneration and loss of vision.


The effect of pergolide on nocturia was independent of improvement of parkinsonian symptoms, suggesting a distinct mechanism from that of anti-parkinsonian effects.


We describe the clinical course of 2 patients with Crohn's disease (CD) in whom lymphoma was diagnosed after treatment with infliximab.


CONCLUSION: A 26-year-old man with bipolar disorder developed hyperammonemia three weeks after initiating carbamazepine therapy.


These observations suggest that depressed thyroid function may be protective against arrhythmias but a patient with preexisting conduction system disease may develop AV block.


While reactivation Histoplasmosis has been reported in the setting of immunosuppression, it remains unclear whether remote primary latent infection represents risk of endogenous reactivation after anti-tumor necrosis factor (TNF)-alpha therapy.


Examination revealed confusion, jaundice, signs of chronic liver disease, portal hypertension and hepatic encephalopathy.


PPI-delayed diagnosis of gastrinoma: oncologic victim of pharmacologic success.


PURPOSE: To report the safety and efficacy of intravitreal triamcinolone in the treatment of inflammatory cystoid macular oedema (CMO) in six patients who were resistant to other forms of therapy.


A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.


She did not use contact lenses postoperatively.


We describe a heroin abuser in whom clinical and laboratory manifestations of acute hepatitis B and C appeared a few days after the insertion of a subcutaneous naltrexone implant.


Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.


Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism.


A 25-year-old factory worker sustained inhalation injury and 2 per cent deep burns while fighting a fire in his factory (LSI factory) which was made of new synthetic building materials.


Ciprofloxacin-induced hemorrhagic vasculitis is a rare side effect.


A retrospective analysis using a bone marrow sample showed the presence of chimerism already at a time when the characteristic full clinical picture of graft versus host disease had not yet developed, opening the way for the early diagnosis and treatment.


Sedative effects may, in fact, be mediated through the benzodiazepine receptor.


It may be concluded that rhEPO is possibly effective in a subgroup of MDS patients where the disease is less advanced.


SUMMARY OF BACKGROUND DATA: CPS has a risk of vertebral artery (VA) injury.


The authors present a woman with profound lower extremity weakness and sensory abnormality after falling asleep in the head-to-knees yoga position (also called "Paschimottanasana").


Phenylpropanolamine (PPA) is a sympathomimetic drug contained in numerous over-the-counter and prescription decongestants and appetite suppressants.


CONCLUSION: Infliximab can be used successfully for the treatment of pediatric patients with Crohn's disease and IPAA who are refractory to conventional therapies.


The visual loss in this patient seems to result from phenol neurotoxicity rather than mechanical compression of the intraorbital optic nerve.


Granulocyte colony stimulating factor (GCSF) was administered to one patient and in another a bone marrow biopsy was performed due to persistent anemia, leukopenia, and thrombocytopenia.


Surgeons should consider stopping carbamazepine before operations with cardiopulmonary bypass.


RESULTS: Five patients were identified.


Second-line chemotherapy with pemetrexed 500 mg/m2 intravenously every 3 weeks was commenced.


Confirmation of the suspected drugs that cause hypersensitivity reaction is sometimes difficult.


Treatment of anticholinergic-induced ileus with neostigmine.


MAHA developed 2 months later, and tumor recurrence with rapid deterioration appeared 5 months later.


A 66-year-old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin-specific antibody fragments.


OBJECTIVE: To report a case of possible foscarnet-induced severe hypomagnesemia and other electrolyte disorders.


Inadvertent globe perforation resulted in subsequent rhegmatogenous retinal detachment.


We present the first case of WES in an infant born to a mother taking haloperidol during her pregnancy.


This is a report of a 9-year-old epileptic boy, who was studied over a period of 7 years.


A case of phenytoin-induced hepatitis with mononucleosis is reported, and syndromes associated with phenytoin hypersensitivity reactions are discussed.


Gemcitabine is a known risk factor for hemolytic uremic syndrome (HUS), which can often have a rapidly fatal clinical course despite intervention with steroids, plasmapheresis and hemodialysis.


A longitudinal case report shows a sudden remission of the severe course of a seasonal bipolar disorder after 10 years of psychopharmacological treatments.


Red blood cell anemia in a patient with pemphigus vulgaris induced by the use of mycophenolate mofetil and prednisone.


Aggressive management of doxorubicin-induced cardiomyopathy associated with 'low' doses of doxorubicin.


Ultrastructural, fluorescent, and energy-dispersive x-ray microanalysis study.


A pituitary adenoma was removed, vision recovered, and the pregnancy completed successfully.


We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation.


METHODS: Eight patients with cutaneous ulcerations from cryofibrinogenemia were treated with stanozolol.


Subsequently, in 1998, the observation of a significant 49% reduction in invasive breast cancer relative to placebo in a cohort of women at increased risk for the disease resulted in the early stopping of the National Surgical Adjuvant Breast and Bowel Project's (NSABP) P-1: Breast Cancer Prevention Trial (BCPT).


The pharmacologic agent bisphosphonate has recently received much attention in the dental literature.


The authors reported two cases of vasculonecrotic phenomena in lepromatous leprosy sharing clinical and histopathological characteristics of both reaction subtypes.


Investigation revealed advanced metastatic disease with a probable primary in the right lung.


METHODS: Two patients with long-term hydroxychloroquine use, subtle perifoveal ophthalmoscopic pigmentary changes, and bilateral perifoveal defects on automated Humphrey visual field (HVF) 10-2 perimetry were imaged using SD-OCT and AO.


The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.


The pathophysiology and management of myoclonus are discussed.


We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).


We describe a case of recurrent impetigo herpetiformis in an 18-year-old pregnant woman who had normal serum calcium levels and responded well to prednisolone therapy.


In all patients, the IOP increase was sustained across several visits, requiring control with topical glaucoma therapy, and in two cases the addition of a systemic carbonic anhydrase inhibitor.


CONCLUSION: Acetic acid is corrosive and may cause vagina bleeding.


The patient had none of the risk factors known to influence the response to the coumarinic derivative except that she carried the rare *3 allelic variant of the cytochrome P450 CYP2C9 in a homozygous status.


It remains to be seen whether the hepatotoxicity associated with troglitazone is a drug-class effect or specific to troglitazone.


Mycosis fungoides progression and chronic solvent exposure.


The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus, therefore, in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment.


Sprague Dawley and Brown Norway rats were ovariectomized and randomly assigned to treatment groups (subcutaneous implantation of either a capsule containing 20 mg 17beta-estradiol or an empty capsule, as a control).


We report a patient with supralethal magnesemia of 38.7 mg/dL who survived.


The patient demonstrated radiographic signs of pulmonary aspergillosis and biochemical signs of hepatic involvement that were resistant to a 23 day course of conventional AMB (Fungizone) therapy.


CONCLUSIONS: Infants can be exposed to clinically relevant doses of lamotrigine through breast-feeding.


Combination cytotoxic chemotherapy was used to treat a case of acute myeloid leukaemia presenting in the 25th week of pregnancy with a sustained complete remission of the leukaemia and the successful delivery of a normal infant.


Treatment of Paecilomyces infections may require multiple courses of antifungal therapy, often with surgical debridement.


Two ajmaline tests were both negative and ruled out the diagnosis of BS.


A drug-induced psoriasiform eruption due to these drugs seems to be more common than previously reported.


TEN is often a drug-induced reaction and virtually any drug class appears capable of provoking it.


The report emphasizes a thorough and detailed assessment of deaths which occur during treatment with neuroleptic drugs.


Development of an organic affective syndrome during a hyperbaric diving experiment.


A case of actinic prurigo and solar urticaria.


Dapsone is increasingly used in the treatment of rheumatic diseases.


After ciprofloxacin treatment, the ulcer healed and visual acuity recovered to 20/20 with spectacle correction.


The patient's blurred vision gradually improved, but visual field defect remained.


This was felt to be primarily induced by doxorubicin.


Enuresis is a common paediatric problem which is sometimes treated with anticholinergic drugs.


The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.


A case report.


CASE REPORTS: Case 1.


Furthermore, this analysis does not provide evidence for a heightened risk of AML/MDS in CLL patients, despite treatment with known leukemogenic agents.


The other patient had dienestrol, 2.5 mg daily, and later estradiol, 40 mg every 6 weeks.


Objective antitumor responses and significant palliation of symptoms have been demonstrated.


Pancytopenia associated with 5-aminosalicylic acid use in a patient with Crohn's disease.


Intensive high-flux hemodiafiltration is often used in the management of vancomycin toxicity.


Treatment by nitrogen-oxygen saturation at a pressure equivalent of 30 m (100 ft) sea water is proposed.


A young diamond dealer developed visual impairment attributed to bilateral posterior subcapsular cataracts following only four courses of intermittent Decadron used as part of a five-drug antiemetic regimen for cisplatin-associated nausea.


The mite infestation was not noticed at the time of hospitalization.


This finding is explained by a 'flap-flop phenomenon' where drug absorption is the rate-limiting step of overall drug disposition.


Serious phenytoin hypersensitivity reactions may appear as dermatologic, lymphoid, or hepatic syndromes.


We report a case of biopsy proven myositis whose symptoms began within 10 days of receiving leuprolide acetate therapy for prostate cancer.


Nitrofurantoin-induced pulmonary toxicity during pregnancy: a report of a case and review of the literature.


In both patients, no known etiologic factors, such as systemic lupus erythematosus, poststreptococcal glomerulonephritis, sickle cell anemia, or acquired immunodeficiency syndrome, were evident.


A diagnosis of essential thrombocythemia was made by fulfilling the criteria of the Polycythemia Vera Study Group of the National Cancer Institute.


OBJECTIVE: To describe a patient with ifosfamide-induced nonconvulsive status epilepticus.


Drug-induced linear IgA disease with antibodies to collagen VII.


We describe two patients who developed neurological side effects as part of the spectrum of nitritoid reactions.


The stellate ganglion lies medial to the scalene muscles, lateral to the longus coli muscle, esophagus and trachea along with the recurrent laryngeal nerve, anterior to the transverse processes and prevertebral fascia, superior to the subclavian artery and the posterior aspect of the plura, and posterior to the vertebral vessels at C7 level.


The tinnitus is thought to be secondary to rhythmic involuntary movements of the soft palate.


Continuous ambulatory peritoneal dialysis (CAPD) peritonitis is a common problem in patients on peritoneal dialysis, and the bacteriological diagnosis is important for the treatment of this condition.


In one instance a systemic hypoglycemic reaction resulting in head trauma and confusion ended in an emegency hospital admission following the substitution of acetohexamide for acetazolamide.


Detailed immunological investigation of the patient revealed a severely impaired TH-1 cytokine response as the immunological background for this uncommon course.


A single case of encephalopathy and three cases of peripheral neuropathy are the only neurotoxicities reported.


The authors also determined that their case of myositis developing in the rectus abdominus muscle of a patient with pancreatic adenocarcinoma was the manifestation of radiation recall, thereby bringing the number of patients who developed radiation recall to gemcitabine and were discussed in the current study to 13.


The patient received treatment with dexamethasone 0.2% eyedrops every 2 hours.


Joubert syndrome is a rare autosomal recessive disease characterized by hypotonia, ataxia, episodic hyperpnea, psychomotor retardation, abnormal ocular movements, cerebellar vermian hypoplasia, and molar tooth sign on magnetic resonance imaging.


Nonsteroidal anti-inflammatory agents may be an alternative to chemotherapy and radiotherapy in treating mesenteric desmoids.


Olanzapine may be considered a potential and safer treatment for a this specific group of patients.


After treatment with aripiprazole was started, the patient was inadvertently given an inactive drug, resulting in a worsening of her hemiplegic episodes, which improved again on rechallenge.


The natural history of this condition is resolution without sequelae after appropriate therapeutic intervention for the vena cava thrombosis.


Therefore, fixed drug eruption is a newly observable side effect of this drug.


OBJECTIVE: To draw attention to severe presentations of atypical neuroleptic related diabetes and to document that a marked degree of remission can take place after drug withdrawal.


A case is reported of a 36 y/o man treated with radiation therapy for cervical cord ependymoma who developed malignant fibrous histiocytoma of the cervical spine 15 years later.


We concluded that flumazenil can antagonize the sedative effects of promethazine at these receptors to return the patient to a wakeful state.


BACKGROUND: The anti-natriuretic properties of growth hormone (GH) are well established.


Patient A reported right leg weakness (foot drop) during week 4 of CAP-XRT (1600 mg/m2).


Atypically, despite high viraemia, serological tests showed persistently negative HBsAg using three different sensitive HBsAg assays (i.e., Architect, Murex and AxSYM).


However, acute cardiomyopathy and pericarditis secondary to methylphenidate use has been rarely reported.


Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.


She received cyclophosphamide, phenylalanine mustard, urethane, and prednisolone intravenously or orally.


CASE SUMMARY: A 68-year-old woman developed a dry, irritating cough within one month of starting quinapril therapy for the treatment of essential hypertension.


He recovered without sequelae.


Lymphocytes were elevated in bronchoalveolar lavage, and progressively normalized upon discontinuation of the drug.


We report a 44-year-old woman with t-MDS (refractory anemia with excess blasts) following treatment of recurrent anaplastic astrocytoma with temozolomide (TMZ).


OBJECTIVE: To report a case of successful outpatient carboplatin desensitization in a pediatric patient with bilateral optic glioma.


Their parkinsonism improved on discontinuation of metoclopramide therapy.


The cause is presumed to be secondary to hypercoagulability due to asparaginase-induced antithrombin III deficiency.


Three of the patients experienced myalgia and muscle cramps.


Use of glycopyrrolate to treat intraoperative penile erection.


Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases.


Eight weeks later, he experienced pain and redness of the right eye.


Patient was discharged home on postoperative day 19.


At present, no uniformly accepted effective treatment has been described for this condition.


Animals treated with HAL showed a highly significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons in the substantia nigra, and 20% contraction of the TH stained dendritic arbour.


Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.


Since the 3 patients were relatively old (average age, 72 years old) and had various degrees of micro- and macroangiopathies, these side effects may have been associated with increased micro- and macrocirculatory disturbances in their central nervous systems through alpha-glucosidase inhibition of this agent.


The hypoadrenalism was overcome by increasing steroid replacement therapy.


Reactivation of tuberculosis is a complication of its use.


Three days later the patient could say a few single words and extra-ocular movement returned to normal.


Renal failure associated with acetazolamide therapy for glaucoma.


Three hours after the procedure, she had severe headache with vomiting and gradually went into a coma.


A patient receiving long-term corticosteroid therapy for asthma had two episodes of Pneumocystis carinii pneumonia (PCP) 8 years apart.


Sudden reversible vitritis after keratoprosthesis: an immune phenomenon?


All strains were sensitive to linezolid with MIC<4 mg/l.


The embolization of a venous catheter fragment is a rare complication.


PRCA developed 3 years after the thymectomy and she was successfully treated with cyclosporin.


Ultrasonography of the neck and upper extremity revealed thrombosis of right internal jugular vein.


DISCUSSION: Colchicine, the most important drug in treatment of FMF, can cause myopathy in patients with impaired renal and hepatic function.


An insulin-dependent diabetic patient with nephropathy developed severe acidosis after treatment with acetazolamide for glaucoma.


In patients with diabetes mellitus, hemoglobin A(1c) (A1C) is commonly interpreted as a measure of long-term glycemic control, reflecting a mean glucose level over the previous 2-3 months.


Localized dyskeratotic plaque with milia associated with sorafenib.


Patients with lymphoblastic lymphoma who had treatment with L-asparaginase and steroid are predisposed to the development of cortical venous thrombosis and may have this syndrome in addition to a dural puncture headache.


A study of the intra-cellular cytokines in blood lymphocytes showed a production of IL4 from CD4+ lymphocytes after stimulation by gelatine.


After 3 years of experience with patient reporting, we conclude that patient reporting in spontaneous reporting systems is feasible and that it contributes significantly to a reliable pharmacovigilance.


After 3 months of combination therapy, LAM was stopped and ADV monotherapy was continued.


Lithium and maintenance ECT.


CONCLUSIONS: An objective causality assessment revealed that fluphenazine was the probable cause of NMS in this patient.


We report the successful intraoperative resuscitation of a patient with acute intracardiac/intravascular thrombosis during an orthotopic liver transplantation using thrombolytic therapy.


She had been administered tacrolimus for prophylaxis of graft-versus-host reaction.


Early treatment of organophosphate (OP) poisoning with oximes results in reactivation of acetylcholinesterase and patient recovery.


Post marketing studies of Interferon-beta (IFN beta) therapy in multiple sclerosis (MS) have demonstrated surprisingly high rates of hepatotoxicity.


There was evidence of extrarenal vascular disease in 12 patients and preexisting renal impairment in 13.


Beneficial late administration of obidoxime in malathion poisoning.


She was found to have PTLD of the nasopharynx.


Patients receiving combination therapy with colchicine and simvastatin, particularly in the presence of renal insufficiency, should be monitored for the development of myopathy, including rhabdomyolysis.


We present a case report of a patient with alveolar hydatid disease, whose treatment with mebendazole was brief due to side effects of alopecia and granulocytopenia; and review the features of this disease which, with increasing international migration, may be encountered more frequently in Australia.


How much do novel antipsychotics benefit the patients?


The DLK in this patient is delayed longer than typically reported in the literature.


The favourable outcome in these two patients contrasts with the fatal outcome of the two other reported cases of nitrofurantoin induced BOOP.


The patient was diagnosed as having a cerebral dural sinus thrombosis, but only after the diagnosis was missed initially.


After 3- to 13-month period of therapy without indapamide, glucose levels of all patients decreased and diabetes disappeared.


METHODS: We describe an 84-year-old patient with breast and colon cancer, who complained of a decrease in visual acuity after treatment with low-dose antiestrogens.


Prehospital diagnosis of massive ethylene glycol poisoning and use of an early antidote.


The patient recovered without permanent sequelae.


We report a 51-year-old male with adult T cell leukemia (ATL) who received a BMT from an HLA-identical unrelated donor.


Child-Pugh class A liver function and a platelet count of > or = 60,000/mm(3) were among the inclusion criteria for SHARP.


After being seizure-free for at least five years on phenobarbital and carbamazepine, she experienced seizures related to the product change.


Her symptoms and pulmonary nodules resolved following treatment with corticosteroids.


Despite the underlying hepatitis C, this case represents renal abnormalities consistent with IFNalpha therapy for CML.


The administration of phenobarbital in this patient allowed improved symptom control, minimized the potential for propylene glycol toxicity, was not associated with respiratory depression, and facilitated successful weaning of benzodiazepines.


Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).


Minor electrocardiographical changes were noted in five out of six patients who were not receiving a cardiac glycoside and four out of six who were receiving ouabain, and none of the 16 who were receiving digoxin.


CASE SUMMARY: A 54-year-old white man received a heart transplant secondary to ischemic dilated cardiomyopathy.


Within one month the corneal ulcer and infiltration disappeared.


A purple rash in the left submandibular area was noted.


Therefore, ACE inhibitors should be discouraged for the majority of patients with primary aldosteronism, even in the face of renal or cardiac disease.


CASE SUMMARIES: Three severely agitated patients in ICU did not respond to conventional therapy with opiates, benzodiazepines, and intermittent intravenous doses of haloperidol.


It is considered to be an organism with a limited pathogenic potential, which is rarely capable of causing diseases in humans other than in those who are in an immunocompromised state.


After implementation of additional preventative safeguards, no further errors or complications have occurred.


This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.


Group B streptococcal late-onset sepsis with submandibular phlegmon in a premature infant after beginning of breast-feeding.


This side effect has only once previously been reported with the nitrosourea group of compounds.


RESULTS: Ethambutol, and to a lesser extent isoniazid, are both implicated in the development of visually related side effects.


We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.


The subintensive supervision consisted of instrumental monitoring with the assistance of an intensive care anesthetist.


AIM: The aim of this article is to present the clinical characteristics and management of an oral adverse effect stemming from the use of the antiretroviral medication Nevirapine (NVP).


With this therapy left ventricular function improved and CHF resolved in each.


Akathisia is generally considered to result from D2 dopamine receptor antagonism.


METHODS: We present a detailed case report, review the related literature, and suggest the need for prospective studies to determine the appropriate intervention in critically ill patients with pseudo-Cushing's syndrome.


The former patient had complained once that his visual acuity had decreased after the termination of IFN therapy, and the latter patient complained twice during IFN therapy that his visual acuity had decreased.


CONCLUSIONS: Among the many presentations of ifosfamide neurotoxicity, clinicians should consider NCSE as a possible explanation for changes in consciousness in a patient receiving this agent.


He also suffered from acute stroke, and brain magnetic resonance angiography showed total left internal carotid artery occlusion.


One patient with blebitis progressed to culture-positive endophthalmitis.


In patients with an impaired renal function, AZ should therefore be administered very carefully in order to avoid an accumulation of the drug.


She remains cough-free to date.


Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.


Early diagnosis and prompt surgical treatment are the keys to success in the treatment of this limb-threatening complication.


Here, we report the cases of two children who developed typical clinical and biochemical features of BMTN.


Infliximab, a chimeric monoclonal antibody targeting tumor necrosis factor alpha (TNF-alpha), is efficacious in the treatment of rheumatoid arthritis and Crohn's disease.


A report is presented of a patient who developed multiple abscesses of the pancreas due to Candida albicans following an Endoscopic retrograde chole-pancreatography (ERCP) for acute pancreatitis.


The patient presented with several actinic keratoses, squamous cell carcinomas, and multiple keratoacanthomas, one of which was pigmented.


Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.


Risks regarding disseminated intravascular coagulation and bleeding were presented to the parents.


Molluscum contagiosum lesions are presumably common in IRIS but underreported.


Serial respiratory function tests in patients receiving bimodal therapy may facilitate early diagnosis of this potentially serious complication.


Severe psoriasis is commonly associated with depression and may be its cause.


Therefore, both patients received repeated courses of rituximab, an anti-CD20 monoclonal antibody, in combination with irradiated DLI.


Leukemia was treated with courses of adriblastin, cytosine arabinoside, and thioguanin (DAT protocol), with a 8 months' survival.


We describe 3 elderly patients with moderate to severe ataxia that occurred while they were taking propafenone.


Although a neurological evaluation by a neurosurgeon could suggest the presence of a vague cerebellar sign, neuro-otological evaluation disclosed diverse abnormal findings which clearly demonstrated the presence of dysfunction in the cerebellar system, especially of the verminal and flocculonodular lobe lesion.


In two of these cases akathisia resolved after withdrawal of olanzapine and substitution by a classical or an atypical neuroleptic agent, respectively.


Severe disease activity and complications of immunosuppressive therapy: a challenge for acute hospital-based rehabilitation in rheumatology.


The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.


With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.


Endoscopy showed a normal colon, histopathology of random biopsies of all sections of the colon demonstrated the characteristic features of collagenous colitis.


We report the case of a patient with chronic lymphocytic leukemia (CLL) who developed fatal intravascular autoimmune hemolytic anemia (AIHA) after fludarabine treatment.


The study was closed early for safety reasons as there were three unexpected treatment-related deaths.


Histopathologic study of the ecthyma gangrenosum-like lesion, as well as pustular lesions, revealed epidermal necrosis and an inflammatory infiltrate in the upper dermis, with numerous septate hyphae demonstrated by periodic acid-Schiff stain.


Discontinuation of the itraconazole caused resolution of the drug eruption.


We present a case of severe unilateral posterior scleritis associated with zoledronic acid administration that was recognized and treated in a timely manner.


Over the next few days, signs and symptoms of hepatotoxicity progressed, and she became comatose.


He admitted to our hospital and tricuspid valve endocarditis was proved by echocardiography.


A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acute myocardial infarction.


The patient rapidly responded to intravenous ampicillin.


Low-dose oral methotrexate treatment for recalcitrant palmoplantar pompholyx.


Mesalamine-induced hypersensitivity pneumonitis.


Several possible explanations of the mechanism of renal failure associated with the use of dextran-40 are discussed.


Therefore, amantadine was permanently discontinued and the cornea cleared again.


The patients developed uveitis, sometimes in combination with a transient rash, arthralgia, arthritis, jaundice and pseudojaundice.


Behavioural changes were not related to seizure activity.


There were 15 (55%) patients that responded, three with a complete and 12 with a partial response with a mean duration of response of 13.4 months.


We report a case in a teenage female recently started on oral contraception.


His immunosuppressive medication had been tapered to 15 mg/day of prednisolone.


RESULTS: Of the 18 patients treated with MMF, there were 11 men (61.1%) and seven women (38.8%), with an overall mean age of 55.5 years.


Clinical experience with Chymopapain casts doubts upon the reported results of the limited double blind studies done mainly by surgeons and their residents, relatively inexperienced in the disc injection technique.


Complete lysis of the thrombus was observed after 6 months of treatment with UFH and LMWH respectively without any further complications.


INTRODUCTION: We describe the neurointensive care (NIC) management of a patient with severe cerebral swelling and raised intracranial pressure (ICP) after severe sodium valproic acid (VPA) intoxication.


Disulfiram-induced fulminant hepatic failure in an active duty soldier.


These organisms are, however, sensitive to vancomycin.


She developed skin changes, diabetes mellitus, heart disease, recurrent infections, generalized joint and abdominal pains and liver failure.


A case of propranolol overdose complicated by esophageal spasm preventing extrication of an orogastric lavage tube and relieved by intravenous glucagon is presented.


Amiodarone was discontinued, and thyrotoxicosis gradually abated.


CONCLUSION: An antidepressant which has been effective for as long as 7 years may still carry risk of inducing agitated dysphoria, even in apparently unipolar depression.


CONCLUSIONS: Acute severe hepatitis though rare is occasionally observed with EGFR inhibitors gefitinib or erlotinib.


In order to achieve complete anticoagulation, patients were switched to bivalirudin, which determined a prompt effect on measured ACT.


Analysis of the literature on scrofuloderma between 1978-1993 disclosed that the number of cases with extracervical involvement are increasing.


In order for him to receive the needed chemotherapy, we developed a desensitization protocol that was administered in the intensive care unit.


An unusual case of necrotizing fasciitis with extensive soft tissue infection stemming from a prolonged case of osteonecrosis of the jaw presented.


A 78-year-old man with severe chronic obstructive pulmonary disease presented to our pain medicine clinic for treatment of post herpetic neuralgia.


We report a case of successful management of iatrogenic intravitreal triamcinolone acetonide for intermediate uveitis.


We highlight two instances of systemic allergic reaction, and discuss the potential side effects of local aprotinin injections in the orthopaedic setting as well as the evidence base for its use.


We report liver biopsy findings in a follow-up biopsy of a patient who had been switched from azathioprine to mycophenolate mofetil for treatment of presumed, steroid-responsive autoimmune hepatitis.


DiGeorge's syndrome in monozygotic twins.


We report here the successful use of ONSF to restore vision to three consecutive patients with pending anterior RION, and the importance of early identification and intervention in these potentially reversible cases.


Primary biliary cirrhosis and polymyositis.


A 55-year-old male patient with hepatitis B-related liver cirrhosis was found to have advanced hepatocellular carcinoma.


Chest x-ray and computed tomography revealed multiple patchy infiltrates in both cases; after several days, these confluent infiltrates developed into pneumatoceles.


Abnormal metabolism of valproic acid in fatal hepatic failure.


A prospective controlled trial comparing the treatment effects of psychostimulants and donepezil on patients having opioid-induced sedation is underway.


Rifampicin, an antituberculous drug, causes increased hepatic metabolism of steroid hormones.


OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.


CONCLUSIONS: Cicatrization in the substantia propria of the conjunctiva by excessive lymphocytic infiltration after topically administered antiglaucoma drugs including dipivefrin is a possible mechanism of action for entropion.


We have observed an increasing number of autopsies on patients with chemotherapy-related complications.


Toxicology testing confirmed the presence of strychnine in blood, gastric aspirate, and urine.


We present the case of a 5-year-old girl who developed bilateral vocal cord paralysis following preoperative peritonsillar bupivacaine infiltration.


Patients should be injury advised to seek prompt ophthalmic consultation after LASIK.


Hemodialysis was shown to remove ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide from the blood stream.


In this case, CIPS was considered to be probably associated with cyclosporine according to the Naranjo probability scale.


Histology showed foci of dyskeratosis in the mucosal layer and a polymorphic perivascular inflammatory infiltrate of the papillary dermis, suggesting a drug-induced skin reaction.


Post-allogeneic BMT complications include graft-versus-host disease (GVHD).


Fluid volume expands with a resultant hyponatremia which, depending on the degree, may be asymptomatic or result in death.


We report on a case of a female patient with a chronic schizoaffective psychosis, who was treated for 3 months with 3 x 3 mio IE IFN-alpha s.c./week because of a chronic hepatitis C (genotype 1b).


Methylphenidate and dextroamphetamine are central nervous system stimulants used in the treatment of attention deficit hyperactivity disorders in children.


All of the cats were hyperglycemic for most of the day.


Churg-Strauss disease (CSD) is a rare allergic disorder that is associated with vasculitis, peripheral eosinophilia and allergic asthma.


Despite satisfactory hemodynamic measurements under general anesthesia, we postulated that she suffered from increased pulmonary vascular reactivity and commenced her on Sildenafil treatment.


Unlike the persistently elevated serum HBV DNA level, the serum ALT and AST levels have gradually decreased.


We report a case of Ritalin-associated cataract and glaucoma.


BACKGROUND: Hemangiomas pose a therapeutic challenge because they can threaten vision in infancy and early childhood.


Corneal edema resolved completely after 2 weeks, although reduced endothelial cell count and abnormal morphology persisted.


The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.


Cryoglobulinemic MPGN was suspected and kidney biopsy was performed, resulting in a diagnosis of minimal change disease (MCD).


The other patient had locally advanced anal carcinoma and received concurrent 5-fluorouracil, mitomycin, and radiation therapy.


Transient obstruction of the mitral valve by a massive thrombus complicating percutaneous valvuloplasty.


Mirtazapine had been started 8 days earlier to control major depression.


Milk-alkali syndrome was first described 70 years ago in the context of the treatment of peptic ulcer disease with large amounts of calcium and alkali.


Liver toxicity, although not mentioned among the possible adverse effects of corticosteroids, has been occasionally reported in literature.


Cis-retinoic acid (RA) may further increase the risk of developing BMTN.


Six weeks after withdrawal of the antituberculosis drugs and conservative management, the boy was clinically well and ten months later he remained well clinically and liver function tests, anti-DNA antibody and antinuclear factor tests were normal.


A case is reported of a true monocytic leukemoid reaction in a patient with myelodysplastic syndrome related to the effect of corticosteroids on the underlying marrow disorder.


A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide.


His arthritis remained quiescent while taking the drug and following its withdrawal his condition relapsed and his serum IgA level returned to normal.


SSTR2A was also expressed in lymphocytes that had infiltrated thyroid tissue in Hashimoto's thyroiditis.


One week after the surgery, the patient developed a corneoscleral perforation with iris prolapse.


Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole.


Electromyographic investigation revealed a myopathic pattern in proximal muscles without any neuropathic changes.


The total amount ingested range from 14.3 to 99.3 mg/kg (mean, 54 mg/kg).


Treatment of children with refractory acute lymphocytic leukemia with vincristine and diltiazem.


Treatment of BK virus-associated nephropathy with Cidofovir in renal transplantation.


METHODS: The records of all five diabetic aircrew were reviewed.


Exacerbations of the heart failure were temporally related to the administration of the antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559).


We report on a patient with a high grade B-cell lymphoma who presented 28 days after the second autologous stem cell transplantation with weight gain, ascites, hyperbilirubinemia, and liver venules occlusion as demonstrated by sonography.


Abdominal ultrasound was normal with the exception of a slight hepatomegaly without any lesions, focal or diffuse.


MANAGEMENT: Intravenous dobutamine and dopamine for cardiogenic shock and discontinuation of interferon alpha-2b.


A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.


The treatment of visceral leishmaniasis (VL) may be complicated by drug toxicity or intolerance, and by drug resistance.


Here, we report another such case.


Presented is a case story of a woman with classical rheumatoid arthritis, who during introduction of sulphasalazine (SASP) therapy developed a severe and lasting psoriasis-like skin reaction.


Although various manifestations of pentamidine-induced cardiotoxicity have been reported, to our knowledge, second-degree heart block associated with this agent has not been described.


Treatment with itraconazole of widespread tinea corporis due to Trichophyton rubrum in a bone marrow transplant recipient.


Drug-induced rhabdomyolysis during pregnancy is extremely rare.


Treatment of alternating hemiplegia of childhood with aripiprazole.


BACKGROUND: Nocardia exalbida was first reported in 2006.


Psoriatic arthritis complicating lung cancer.


Congenital cytomegalovirus (CMV) infection occurs in approximately 1% of newborns and is the leading infectious cause of congenital birth defects.


Systemic lupus erythematosus: association with psoralen--ultraviolet-A treatment of psoriasis.


A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.


We present an unusual case of verified myocardial infarction without surgery.


We report the first case of rhabdomyolysis related to the administration of clarithromycin without concurrent use of other medications.


Drug-induced iatrogenic lung disease.


Prior cases are reviewed.


Osteonecrosis is a feared complication of corticosteroid use.


A 57-year-old man developed chronic, watery diarrhea four weeks after Helicobacter pylori eradication therapy including lansoprazole followed by lansoprazole monotherapy for gastroesophageal reflux disease.


DISCUSSION: Because of the close time relationship between drug administration and the development of symptoms and signs, as well as between drug withdrawal and changes in WBC count and ANC, the episodes of neutropenia were suspected to be drug related.


Myoglobinuria and acute renal failure associated with intravenous vasopressin infusion.


Today hairy leukoplakia has come to represent a sign of immunosuppression and not just of HIV infection.


Multiple seizures after bupropion overdose in a small child.


A 21-year-old woman developed epilepsy, disturbance of mental state, and spastic tetraparesis during the convalescent period after acute viral encephalitis.


The eruption cleared on withdrawal of the drug.


A biopsy was performed and evidence from light microscopic analysis of the tissue led to a diagnosis of TEN.


She was diagnosed with Epstein-Barr virus-associated polymorphic lymphoproliferative disorder (LPD) due to immunodeficiency caused by MTX administration.


The patient may have concomitant systemic disease, and the injury occurs with relatively mild trauma.


Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report.


A 52 year-old male patient diagnosed of ankylosing spondylitis presented with an iron deficiency anemia after a ten-month treatment of methotrexate.


Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.


Fever, rash, and lymphadenopathy often accompany hepatic injury.


We remind clinicians that phenytoin toxicity can easily mimic a cerebellar lesion or alcohol intoxication, and suggest that in accordance with National Institute for Clinical Excellence (NICE) guidelines phenytoin should no longer be used as a first-line treatment for epilepsy.


CASE SUMMARY: A 16-day-old infant developed several mild episodes of apnea that culminated in a severe cyanotic episode requiring resuscitation.


However, repeated intracameral tPA injections may cause unwanted complications such as vitreous hemorrhage.


Mono-octanoin (glycerol-1-mono-octanoate) is a medium-chain diglyceride used to dissolve gallstones.


Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocyte leukemia.


The cause of the cerebrospinal fluid leak and different treatment approaches are discussed.


Vaccination as a triggering event for autoimmune hepatitis.


Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.


In contrast to the symptoms during monotherapy with IFN-alpha, during the time of both combination treatments, no psychiatric side effects occurred.


However, little is known about this complication immediately after vertebral artery stenting.


SETTING: Intensive care unit of a tertiary care hospital.


Rescue of haemopoiesis by a combination of growth factors including stem-cell factor.


Diabetes Mellitus was observed in a patient given carbamazepine.


To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.


Patient 1 developed squamous cell carcinoma of the skin with recurrence, and Patient 2 developed anaplastic carcinoma of the urinary bladder.


METHODS: The patient was treated with an ICP-guided protocol including mild hyperventilation, normovolemia, head elevation and intermittent doses of mannitol.


We report the case of a 27-year-old Indian woman who developed maculopapular rash and angioedema secondary to carbamazepine administration.


When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity.


Five days after the fourth dose of vincristine, she presented with bilateral ptosis.


We present a case in which a bolus intravenous injection of sulprostone 30 micrograms was administered to treat postpartum haemorrhage during caesarean section.


This case highlights the potential danger of high dose vitamin supplements in children, and the salutary effects of treatment with bisphosphonate.


A clinical and microbiologic response occurred when anticoagulation therapy with heparin was added to the treatment regimen.


CSF examination revealed an inflammatory profile.


Vitamin D, whose primary action is to facilitate intestinal absorption of calcium, may also be a hormone of prime necessity in infant bone formation.


The other patient presented with typical cutaneous polyarteritis nodosa which responded well to corticosteroid treatment.


He developed a foreign-body sensation and persistent superotemporal corneal erosion as a result fo an adrenochrome deposit on the upper tarsus.


We made the diagnosis of acute gouty arthritis arising from tumor lysis and liver infarction caused by HCC ablation, which was aggravated by acute renal insufficiency.


Aluminum intoxication, along with other factors, was considered to be the cause of TC development.


There is a dose-effect relationship between doxorubicin and the incidence of symptomatic cardiac failure.