We describe a unique case of disseminated cryptococcosis presenting as colitis that mimicked an exacerbation of Crohn's disease in a TNF-alpha inhibitor recipient.


Two of them could not be considered primary: in one the pain was related to an underlying, pointed and benign lesion disclosed only by magnetic resonance imaging (case 1); the second one had persistent NH days after trans-sphenoidal surgery for a pituitary adenoma, similar to a postcraniotomy headache (case 2).


It is common practice in critical care areas for registered nurses to administer antiarrhythmics without a doctor's prescription in life-threatening situations.


Although the patient recovered from her renal failure (creatinine clearance 43 ml/min), the nephrotic syndrome persisted (13 g protein/day).


Delayed pseudocyst of the pancreas can be a complication of intramuscular L-asparaginase.


An early gestational insult, rather than a mutation, may be one cause of this heterogenous disorder.


The cost of the demanding lifestyle of military aircrew members and the fear of hypoglycemic episodes can result in periods of sub-optimal glucose control.


S-1 was safely administered in outpatients and showed some efficacy in the treatment of recurrent/metastatic head and neck cancer in patients who had received previous chemotherapy.


Doxycycline-induced hypoglycemia in a nondiabetic young man.


Several courses of oral voriconazole were required for resolution of the infection.


CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.


These symptoms worsened over 24 hours despite discontinuation of therapy, then gradually decreased in severity but persisted until his death two months later.


The authors emphasize that this patient did not have any predisposing factors to fungal infections.


She continued to receive regular insulin 4 times per day over the following 3 years with only occasional hives.


The most well-described presentation is diffuse lamellar keratitis (DLK), which typically develops early after LASIK and responds quickly to topical steroids.


The mechanism by which ciprofloxacin causes these adverse effects is not fully understood.


Investigation of the cause of death in a gene-therapy trial.


Pustular psoriasis elicited by streptococcal antigen and localized to the sweat pore.


In North America, the adult tapeworm of Taenia (Multiceps) serialis is found in canids.


METHODS: Two case reports.


Overall, there were no relevant changes in clinical ratings including adverse effects.


OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.


The influence of diuretic therapy in combination with lithium is felt to enhance the risk of intoxication.


Warfarin resistance and enteral feedings.


The presence of olanzapine was confirmed by gas chromatography-mass spectrometry by use of electron impact ionization.


Three relevant cases are reported and a review of the published literature is made.


Teicoplanin-induced agranulocytosis that followed vancomycin-induced agranulocytosis suggests a possible cross-reactivity between the 2 drugs.


A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.


Our data is consistent with the notion that elevated blood levels of PTH in patients with chronic renal failure participate in the genesis of anemia of renal failure.


Clinical notes on the possible anticholinergic reversal of depressive syndromes.


The technique of immunocytochemistry was used to identify myoglobin in kidney, confirming a diagnosis of neuroleptic malignant syndrome following an otherwise obscure autopsy in a decomposed body.


The first signs of joint manifestations started one year after HIV seroconversion and resolved when antiviral treatment with AZT was started.


Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.


Before starting Zoledronic acid therapy, the patient's serum calcium level was 6.9 mg/dl.


We report the case of a woman who developed photo-onycholysis on multiple nails after uptake of olanzapine.


Previous studies showed that clevudine has potent and sustained antiviral activity without causing viral resistance.


Serum liver tests showed a mean total bilirubin of 1.4 +/- .7 mg/dL (range, .5-2.5) and INR was 1.2 +/- .14 (range, 1.0-1.4).


Treatment of APL in pregnancy is controversial as the use of ATRA has been questioned due to the teratogenic effect of retinoids.


Profound hypoxemia during treatment of low cardiac output after cardiopulmonary bypass.


The case was unusual in the rapidity and magnitude of hepatic enzyme elevation.


This article presents a patient with hypoparathyroidism who was treated with calcium carbonate and calcitriol resulting in two admissions to the hospital for milk-alkali syndrome.


A bone marrow biopsy did not show signs of hematologic disease, but revealed a small granuloma rife with acid-fast bacilli, which were later confirmed to be Mycobacterium genavense by gene sequencing.


Lithium toxicity in a neonate.


According to the Naranjo adverse drug reaction probability scale, cesium was the probable cause of the patient's arrhythmia.


The patient was given combined antibiotics and the abscess drained surgically.


Combined clozapine and electroconvulsive therapy for the treatment of drug-induced psychosis in Parkinson's disease.


A case report.


The presence of a myopathy could render this patient susceptible to the respiratory effects of opioids.


Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.


With improved treatment and outcome of lupus, an increasing number of elderly patients who are susceptible to osteoporotic fractures are expected.


Our case report is focused on a woman receiving hemodialysis (HD) with diabetes mellitus for 20 years and severe secondary hyperparathyroidism, who presented painful subcutaneous nodules, skin necrosis and ulcerations.


In this report we describe a patient with hyperthyroidism whose symptoms initially were thought to be adverse effects of the inhaled bronchodilator medications.


Severe hepatotoxicity from phenobarbital occurred in an infant boy who had a complicated illness with chronic bilateral subdural hematomas and sepsis.


The overall rate of avascular necrosis in Crohn's disease was less than 0.5% but for men with Crohn's disease was about 1%.


Clofazimine enteropathy caused by crystal deposition can be life-threatening.


However, double-blind, placebo-controlled studies are necessary to confirm these preliminary results.


However, this report suggests that a further endoscopic intervention may be necessary in case the dissolved bezoars cause small-bowel obstruction during this form of therapy.


Pentazocine-induced fibrous myopathy and localized neuropathy.


A 9-year-old girl with AIDS was brought to the emergency department because of tetany.


Peripheral neuropathy was not fully reversed in all patients.


We herein described an additional patient with BCR-ABL (ela2) positive acute lymphoblastic leukemia who developed tumor lysis syndrome after 10-day treatment with imatinib.


A previous review described data on 15 patients who experienced acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP or secondary thrombocytopenia.


A few cases of severe skin reactions such as toxic epidermal necrolysis have been reported.


Sorafenib induced tumor lysis syndrome in an advanced hepatocellular carcinoma patient.


In two patients, aprotinin infusion was added to heparin to treat bleeding, occurring after few days of bypass and responsible for respiratory and hemodynamic deterioration.


BACKGROUND: Metastatic renal cell carcinoma (MRCC) has been characteristically unresponsive to chemotherapy.


It is well known that exposure to manganese, solvents, or carbon monoxide in an occupational setting may lead to central nervous system damage and parkinsonism.


Two case histories are presented illustrating the difficulties of treating candida septicaemia.


Post-dural puncture headache, intracranial air and obstetric anesthesia.


I report a patient who developed the syndrome during treatment for schizophrenia with the antipsychotic agent molindone hydrochloride.


Acute severe intoxication with carbamazepine is associated with seizures, coma and respiratory depression.


Furthermore, the authors provide diagnostic and treatment options that are available for mitochondrial disorders, which are of interest to child psychiatrists due to the central nervous system manifestations of these disorders.


Reversible cholestasis with bile duct injury following azathioprine therapy.


Two months later, Pneumocystis carinii pneumonia developed.


Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy.


We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.


Three cases of pseudocyst of the pancreas in two women and one man have previously been reported with the use of intravenous L-asparaginase.


We report 3 children with epilepsy who developed facial motor tics after initiation of CBZ for complex partial seizures.


Tests for antimyeloperoxidase ANCA were repeatedly negative before the drug was started, strongly implicating the drug as the cause of the episode.


It is important for oncologists to recognize this complication and prevent its development if bulky metastatic disease and several pre-existing risk factors, such as multiple and bulky liver metastases, elevated lactate dehydrogenase, and hyperuricemia, are present.


This medicine is available without prescription and contains the potent oxidant ethyl nitrite.


Systemic lupus erythematosus (SLE) was suspected as a possible etiologic or modifying cofactor in TEN in this case.


This observation questions the suitability of aspirin as prophylaxis for vascular disease in patients with meningiomas.


Treatment possibilities of this multisystem disease up to now remain disappointing.


Moreover, antibody therapy does not take effect immediately, as is understandable in view of the mechanism of action.


The prognosis of t-MDS is generally poor.


Several responses and 2 complete remissions occurred.


A review of the literature regarding the pathogenicity of this organism and, in particular, its occurrence as a cause of pneumonia is presented.


We report an unusual case of simultaneous transitional cell carcinoma of the renal pelvis and distal ureter without transitional cell carcinoma of the bladder occurring after chronic cyclophosphamide therapy for nonHodgkin's lymphoma.


Immune thrombocytopenic purpura (ITP) was diagnosed, and she was treated with 40 mg of methylprednisolone per day for 19 days.


Although neurotoxicity is a frequent complication of methotrexate therapy, fatal acute neurotoxicity is extremely uncommon, especially in adults.


Management of toxic epidermal necrolysis in a 15-year-old girl.


The sorrow of mistakes has been expressed as the too-lateness of human understanding as it lies along the continuum of time, and as a wish that it might have been different, both then and now" (p.149).


CONCLUSION Inhibition of mTORC1, pathologically activated by loss of the TSC1/TSC2 tumor suppressor complex, is a rational mechanistic target for therapy in PEComas.


This case report describes an adolescent with severe lupus erythematosus who received cyclophosphamide (CY) paired with taste (cod liver oil) and smell (rose perfume) as conditioned stimuli.


Severe transplacental lithium toxicity in a neonate is described.


Analyzing the cardiac time intervals during pregnancy can improve perinatal outcome.


METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.


Nonspecific but significant abnormalities have been described in the infants of women treated with disulfiram in the first trimester of their pregnancies.


Anticoagulant theraphy was started.


Because of a hypersensitivity reaction, initial therapy with penicillin G and gentamicin was stopped and substituted with cefazolin.


Research has shown that atypical antipsychotic also reduce the craving and consumption for stimulants and alcohol.


She was receiving phenytoin sodium 300 mg/day; carbamazepine 200 mg four times daily had been discontinued four days before admission because of leukopenia.


Two months after the transplant she developed an interstitial pneumonia: bronchoalveolar lavage yielded cytomegalic cells with intranuclear bodies, and cytomegalovirus DNA was detected by in situ hybridization techniques.


He received 174 gm of intravenous calcium for total of 12 days.


Steroids were given promptly on the day following onset of pneumonitis, and the patient (72 years old) recovered almost completely within one and a half months.


However, it also highlights the importance of determining a patient's tuberculosis status, initiating prophylactic anti-tuberculosis therapy prior to starting treatment with etanercept, and setting up an adequate treatment regime if the patient develops active tuberculosis during therapy with etanercept.


In one patient this resulted in an ischemic and necrotic digital ulcus, necessitating surgical amputation.


Administration of lamotrigine, especially in combination with valproic acid, may lead to the development of TEN.


Immunofluorescent studies showed deposits of immunoglobulins and C3 in a granular pattern in the glomerular basement membranes.


Pelvic arterial pseudoaneurysm-a rare complication of Cesarean section: diagnosis and novel treatment.


We report a case of generalized cutaneous sclerosis associated with muscle and oesophageal involvement in a patient exposed to herbicides containing bromocil, diuron and aminotriazole.


During SIRT, (90)Y-microspheres are infused into the hepatic artery.


Phenytoin levels were measured and found to be grossly elevated at 170 mmol/L.


Thus, clinical recognition of sleep disordered breathing should be taken into account when rheumatoid arthritis patients are to be treated with infliximab.


When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.


A case is presented in which the catatonic-like behavior and extrapyramidal sequelae of the neuroleptic malignant syndrome responded to combined treatment with anticholinergics and levodopa/carbidopa.


He had a low-level PVB19 load for a 5-mo follow-up period without recurrence of PRCA, and finally the virus was cleared.


Both patients were treated with low-molecular-weight heparin in addition to pre-existing ACE inhibition.


Interferon and other immunostimulatory medications can lead to an exacerbation of this preexisting low-grade chronic inflammation that is quite similar to interferon-triggered sarcoidosis.


A case of acute cardiomyopathy and pericarditis associated with methylphenidate.


Very rarely, P. avidum causes systemic infections after invasive procedures, most notably in immunocompromised patients.


BACKGROUND: Merkel cell carcinoma is a rare and aggressive neuroendocrine skin cancer with a very low incidence in the general population.


BACKGROUND: Primary ovarian lymphoma is an extremely rare disease and limited count reports about it have been reported in the literature.


Two cases of ovarian torsion after gamete intra-Fallopian transfer are described and the roles of ovarian manipulation during the procedure, ovarian hyperstimulation and pregnancy as predisposing factors are discussed.


Dural sinus thrombosis in children with acute lymphoblastic leukemia.


BACKGROUND: In the past 9 years, drugs for erectile dysfunction (ED) have been increasingly prescribed for men with erectile difficulty.


An increased incidence of different malignancies associated to chronic lymphocytic leukemia (CLL) has been reported.


A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.


Cryptococcal meningitis in a child with systemic lupus erythematosus.


We suggest that nicotinic acid was the cause of his liver disease, that this case is of particular note because of the rather short period of therapy before the onset of liver injury and the severity of the hepatic failure, and that the probable increased use of nicotinic acid for serum cholesterol control makes it especially important for physicians and their patients to be alert to the signs of hepatotoxicity.


This case study reports the effects of a treprostinil accidental overdose in a patient with pulmonary hypertension.


Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy.


Of twenty other patients in our practice who received gemcitabine for refractory lymphoma without developing pericardial effusion, none had received prior direct radiation to the heart.


Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients.


Indolent aspergillus arthritis complicating fludarabine-based non-myeloablative stem cell transplantation.


OBJECTIVE: To evaluate the efficacy of cyproheptadine in the management of acute intrathecal baclofen (ITB) withdrawal.


None of the patients had worsening of the respiratory status.


This patient rapidly progressed from mild neurotoxicity to fatal encephalopathy after one dose of intrathecal methotrexate during his third cycle of chemotherapy.


We highlight the importance of having a high index of suspicion for hepatic side effects of diclofenac and emphasize the need for increased awareness of this rare but potentially serious problem.


Various toxicities have been observed during the treatment of advanced renal cell carcinoma with interferon-alpha (IFN-alpha) and/or interleukin-2 (IL-2).


The pathogenesis of the liver changes and their possible relationship to splenomegaly and busulphan toxicity are considered.


Adrenal suppression and failure to thrive after steroid injections for periocular hemangioma.


METHODS: Two patients with exudative age-related macular degeneration were treated sequentially with an intravitreal injection of bevacizumab and developed signs of severe but painless infectious endophthalmitis 2 days later.


Tardive dyskinesia in 2 patients treated with ziprasidone.


CASES: "A" was an 8-year-old boy with attention deficit and chronic tic disorder who developed obsessive-compulsive symptoms within 2 weeks of starting risperidone.


Foreign bodies and bezoars are commonly encountered in children.


We report a case of unintentional overdose of oral pilocarpine tablets that resulted in bradycardia, mild hypotension, and muscarinic symptoms in a patient with Sjogren's syndrome.


Refractory hypoglycemia from ciprofloxacin and glyburide interaction.


Brain hemorrhage is a feared complication of early anticoagulation therapy in patients with cardioembolic brain infarction.


We describe two patients with Boerhaave's syndrome who presented with chest pain mimicking cardiac pain and received heparin therapy.


We report a girl with the Rett syndrome who had acute encephalopathy probably induced by calcium hopantenate (HOPA).


A simple dropper that would withdraw only one drop and deliver the same would resolve this problem.


We report an unusual case of necrotizing scleritis with inflammation that occurred after strabismus surgery.


After tapering of oral prednisolone, cyclophosphamide was started, which resulted in a gradual improvement of proteinuria.


One had a mildly abnormal electro-oculogram.


She had been receiving monthly transfusions of IVIG, but this time had received daily infusions for 5 days rather than 1 day.


The authors' results suggest that L-dopa may cause daytime somnolence in some patients with Parkinson's disease.


Surgical decompression was initially considered and then deferred in favor of observation.


In earlier studies, it was used on a daily schedule with resulting severe gastrointestinal toxicity and myelosuppression.


Finally, the most promising PD drugs that are currently in development will be reviewed.


CONCLUSIONS: Because of its structural similarity to the other vinca alkaloids, vinorelbine is believed to be responsible for SIADH in our patient.


She presented with fever and mild hepatic enzyme elevations before salicylate therapy was instituted.


Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation.


Within the mandibular canal, the IAN runs forward in company of the inferior alveolar artery, and together they are called the inferior alveolar neurovascular bundle.


Fatal radiation myelopathy after high-dose busulfan and melphalan chemotherapy and radiotherapy for Ewing's sarcoma: a review of the literature and implications for practice.


The last injection was immediately followed by an atrio-ventricular tachycardia with massive decrease in blood pressure.


BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.


A diagnosis of infliximab-induced lupus was made and the drug treatment was withdrawn.


Despite premedication with diphenhydramine and dexamethasone, she experienced generalized pruritus and urticaria, as well as headache and chest pain/tightness, after her next infusion.


Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in hypertension due to primary aldosteronism: a case for exclusion.


Five months after the catheter implantation melena occurred.


There was no evidence of renal hypoperfusion or interstitial nephritis.


Therefore, bone marrow follow-up is critical for monitoring of response.


She developed edema, swelling, erythema, and vesicles on her eyelids.


His brother (age 6) and father (age 31) were also found to have elevated blood pressure.


This drug is rapidly absorbed from the gastrointestinal tract, most of which is excreted from the kidney.


Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine.


A potentially fatal ulcerating enterocolitis has been reported in 4 patients.


Lamellar inflammation was exacerbated by topical steroids.


Thrombocytosis induced by enoxaparin has been reported as a rare adverse effect of this medication in adults.


Five patients were infected with a nontyphosal Salmonella species, Salmonella oslo.


We report herein two cases of young adult patients who were both diagnosed with Ph+ ALL 19 years after successful treatment for ES with combined modality therapy.


No other diagnostic criteria for neuroleptic malignant syndrome (NMS) were present.


Renal tubular acidosis secondary to FK506 in living donor liver transplantation: a case report.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


Paradoxical seizures in phenytoin toxicity.


Wilms' tumor with transient dermolysis of the newborn: recurrence of skin lesions during chemotherapy.


The patient completed a 10-month follow-up, maintaining a complete resolution of the treated skin lesions; however, the development of a painful hand ulcer, possibly associated with the hydroxyurea, and new skin cancers were observed at the last follow-up visit.


BACKGROUND: The treatment of colorectal cancer with administration of a 2-h infusion of calcium folinate followed by a 24-h infusion of 5-fluorouracil (5-FU) is a standard therapy.


Upper gastrointestinal haemorrhage is a serious complication of aspirin and clopidogrel (dual) anti-platelet therapy with a high morbidity and mortality.


The use of epidermal growth factor receptor (EGFR) inhibitors for the treatment of solid tumours is now increasing.


We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.


BACKGROUND: Although multiple sclerosis (MS) is a common disease of the central nervous system, the association of intraparenchymal tumour has been rarely reported and the potential relationship between intracranial meningioma and MS has not been seriously analysed.


This approach might represent a promising new strategy for treatment of proteinuria after kidney transplantation.


It has also been associated on occasion with malignancy.


Standard induction chemotherapy [cytosine arabinoside (ARA-C) and daunorubicin (DNR) for AML, vincristine (VCR), DNR and prednisone (PDN) for ALL, all-trans retinoic acid (ATRA) and DNR for APML] with the antracycline dose of at least 30 mg/sqm were used.


A previously healthy 25-year old male with mild tonic-clonic epilepsy was found unconscious with serum VPA levels >10,000 micromol/l.


A 14-year-old girl, dwarfed by systemic disease and long-term corticosteroid therapy, was able to discontinue prednisone and grew 6.3 cm in 11 months following 18 plasma exchanges with FFP.


Until additional data are available, if intravenous acyclovir is administered concurrently with lithium, we recommend closely monitoring patients for signs of lithium toxicity and measuring serum lithium levels every second or third day.


Acute valproate ingestion induces symptomatic methemoglobinemia.


Spinal artery syndrome masked by postoperative epidural analgesia.


Atypical neuroleptic malignant syndrome associated with olanzapine.


Diffuse interstitial pneumonia and pulmonary hypertension: a novel manifestation of chronic granulomatous disease.


Initial hepatic function tests were strictly normal.


beta-Lactam therapy was initiated with vancomycin, cefepime, and metronidazole and, upon identification of methicillin-sensitive Staphylococcus aureus bacteremia 4 days later, therapy was narrowed to cefazolin 1 g every 12 hours.


METHODS: We report a case of a 33-year-old female patient who developed RPE atrophy after a single standard PDT for treatment of a juxtafoveal, predominantly classic choroidal neovascularization (CNV).


Adenosine may be of therapeutic and diagnostic value in the emergency management of arrhythmias.


The treatment of choice is liposomal amphotericin B, which failed in our patient.


Fludarabine induced lung toxicity must be considered in all patients who develop unexplained lung disease while receiving fludarabine.


The corneal ulcer progressed despite aggressive antifungal treatment, requiring amputation of the corneal flap and daily debridement.


Therefore, thorough investigation with an ultrasound-guided aspiration followed by an early drainage of the collection is warranted and mandatory.


Patients had tended to become more neurotic (p = 0.08) and less extravert (p = 0.07).


However, in our experience, these patients are sometimes placed on angiotensin-converting enzyme (ACE) inhibitors in accordance with guidelines applying to the general hypertensive population.


Cutaneous vasculitis secondary to ramipril.


Hypomagnesemia, hypokalemia, and hypocalcemia had developed.


Laser light was applied at a power of 400 mW/cm fiber for a total energy of 180 J/cm.(2) RESULTS: Fourteen treatments were performed on 6 patients with tumors of Bismuth types IV (n = 2), III (n = 3), or II (n = 1).


ARDS is rarely associated with rituximab infusion for lympho-proliferative disorders, but it should be considered by those administering rituximab, especially when a patient develops severe pulmonary symptoms soon after infusion.


These lesions even worsened for some weeks after interruption of cabergoline, which may possibly be related to the prolonged action of this drug.


There is yet no explanation for the occurrence of hallucinations or psychosis.


The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.


Transvenous liver biopsy revealed hepatic angiosarcoma, a rare liver tumor classically associated with environmental toxins.


Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.


Ticlopidine-induced aplastic anemia: two new case reports, review, and meta-analysis of 55 additional cases.


Membranous nephropathy in rheumatoid arthritis.


The patient continued to have fever and autonomic instability without evidence of infection which entirely resolved within 24 hours of reinstitution of full preadmission dosing of oral baclofen.


Due to the more pronounced side effects of BCG compared to intravesical chemotherapy, reluctance still exists about BCG use.


Key Words: renal failure, proteinuria, angiotensin-converting enzyme inhibitor, ACEI, angiotensin II receptor blocker, ARB.


RESULTS: Coagulase-negative staphylococci were identified and isolated from the vitreous specimen of both patients.


Resolution occurred mostly within 24 to 48 hours after injection.


The intent of the discussion is to alert physicians that the appearance of epiglottis can occur from causes other than infection and that a surgical airway should not be the first thought when such a case arises.


Required doses of Danaparoid were consistently twofold that previously reported for adults.


One large and obstructive thrombus with a long and mobile component, and other smaller and mobile thrombi were detected.


We describe 4 patients with Graves disease who had abnormal increases of serum creatine kinase (CK) concentrations during treatment with antithyroid medications.


By the third day, the patient was having one bowel movement daily.


In early endophthalmitis, Staphylococcus epidermidis was isolated on vitreous culture in 4 (67%) of 6 cases, whereas in late endophthalmitis, this organism was isolated in only 1 (4%) of 27 cases.


The dog made a gradual recovery, with complete return of locomotor function and muscle mass within 2 months.


The major affected sites had been treated 10 years before with Artecoll, a permanent filler containing polymethylmethacrylate.


Marked improvement was noted after the discontinuation of minocycline and the use of systemic corticosteroids.


We report a case of posttransplant pulmonary capillaritis in an 8-month-old infant, and demonstrate evidence of C4d deposition and B-lymphocytes in the allograft, donor anti-HLA antibodies in the serum and a clinical and immunohistochemical response to anti-CD20 monoclonal antibody (rituximab) therapy.


Delayed severe multivessel spasm and aborted sudden death after Taxus stent implantation.


Corticosteroids are widely known to have a variety of adverse mental effects.


She also volunteered she had never had a menstrual period and physical examination identified several features of Turner's syndrome.


OBJECTIVES: Multidrug resistant tuberculosis (MDR-TB) is an increasing problem in many parts of the world and in Norway the increase has been substantial since 1998.


Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited.


We report the first case of a human immunodeficiency virus type 1 (HIV-1)-infected individual receiving combination antiretroviral therapy, which included ritonavir, who developed Cushing syndrome with profound complications after epidural triamcinolone injections.


INTERVENTION: Cessation of treatment with 5-ASA compounds.


Both patients experienced the onset of psychiatric symptoms as young adults, showed a prompt response to antipsychotic drug therapy, and were subsequently left on maintenance treatment for indefinite periods.


Cutaneous reactions to propylthiouracil and methimazole occur in 3%-5% of adults.


DISCUSSION: CIPS is hypothesized to result from calcineurin-induced vascular changes that disturb bone perfusion and permeability, leading to intraosseous vasoconstriction and bone marrow edema.


Many of the therapeutic agents that are used in the ICU may precipitate delirium.


Anticonvulsant hypersensitivity syndrome: is there a role for immunomodulation?


CONCLUSIONS: The risk of drug-induced rhabdomyolysis due to the potential interaction between lovastatin and azithromycin or clarithromycin should be considered before the concomitant use of these agents.


SUMMARY: Patients with NSTE ACS for whom a conservative treatment strategy is selected should receive enoxaparin, fondaparinux, or unfractionated heparin (UFH) as anticoagulant therapy.


She was transferred to an inpatient psychiatric hospital, where she was taken off risperidone.


To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.


A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment.


Nevertheless, although rare and usually free of clinically significant sequelae, if contamination is by some virulent organisms such as Staphylococcus aureus, gram-negative bacilli, or fungi, severe complications may occur.


After three weeks of treatment an itching rash appeared.


Most of these patients benefited from therapy and survived longer (median 5 years) than historical control of untreated patients.


A total of 64 patients from 10 series have received the drug from one to 25 months, usually in doses of 50-150 micrograms every eight hours by subcutaneous injection.


The patient was found to have no motile sperm with a normal sperm count, while taking a dose of 400 mg/day of carbamazepine.


CONCLUSION: Rapid infusion of albumin might be a rescue option in cases of severe TRALI with extensive pulmonary capillary leak during the acute phase.


Rhabdomyolysis has been recognized as a complication of tocolytic therapy with ritodrine hydrochloride.


The cough continued for the duration of therapy with quinapril.


All evidence suggests this was an idiosyncratic response to either hepatitis A or yellow fever vaccination.


We report a case of long-term systemic administration of prostaglandin E2 (PGE2) to a newborn infant with ductus-dependent congenital heart disease.


The time delay by which symptoms of pancreatitis presented following administration of loop diuretics suggests an immunologic pathway.


Unfortunately, while there are numerous observational reports in the literature, there is not a lot of information concerning the safety and efficacy of particular treatments or the nontreatment of bipolar disorder during pregnancy.


To best of our knowledge, this entity has never been reported as a problem.


We should always consider it as a possible late complication and treat it appropriately.


Reversible coma in children after improper baclofen pump insertion.


Furthermore, pleiotropic effects of ACE inhibitors are unlikely to provide significant benefits in the absence of blood pressure reduction.


Over the ensuing 3 years, recurrent bouts of optic neuritis OU, with dyschromatopsia, and acuity and field loss (arcuate, central, and paracentral scotomas) were controlled with increasing doses of corticosteroids.


Acute delirium resulting from levofloxacin therapy is an exceedingly rare complication that has been thought to occur more commonly in elderly patients.


MATERIALS AND METHODS: Two dialysis patients with recently rejected renal allografts who were hospitalized because of fever of unknown origin are reported.


Topical steroids remain the mainstay of therapy, but topical tacrolimus has recently been used to treat OLP resistant to topical corticosteroids.


We report here on a heretofore undescribed respiratory syncytial virus (RSV) infection in a patient with a long-standing history of refractory CLL that was treated with fludarabine phosphate.


It is concluded that at least some sensory symptoms originate within the nervous system as a manifestation of the disease process and are not secondary effects of the motor disorder.


Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.


He did not suffer from any allergy but drinking red wine caused vasomotor rhinitis.


A renal route of potassium loss was suspected, but could not be confirmed as potassium excretion did not increase although sodium excretion was augmented [basal sodium output: 56.7 mmol/24 h; phosphate treatment: 153 mmol/24 h (p < 0.05)].


Three cases of acute renal toxicity in patients receiving long-term therapy with mitomycin C and 5-fluorouracil are reported.


Looking at calcimimetics impact on hypercalcemia of immobilization: hypotheses and a case study.


Therapeutic strategy of nephrotic syndrome in patients over eighty.


Two children with rheumatic fever developed anicteric hepatitis while on high-dose aspirin therapy.


A 65-year-old female patient presented with jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat, 1 week after the fourth dose of adalimumab.


We undertook a retrospective analysis of prevalence of QTC prolongation among all patients with computerized ECGs over a 6-month period at one institution and compared it to the prevalence in hospitalized patients with HIV disease.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


Toxoplasma gondii infection reactivation predominantly occurs among patients after allogeneic haematopoietic stem cell transplantation.


We suggest that oversecretions of GH and IGF-I were strong promoting factors for liver tumorigenesis in this patient.


Gabapentin withdrawal presenting as status epilepticus.


A 61 year-old patient with a history of anxiety disorder presented with stridor after an uneventful laparotomy with a general anesthetic.


Leukaemia cutis in a patient treated for breast cancer.


Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder.


Further research is needed to delineate the frequency of this troubling side effect and how best to treat it.


Awareness of this may obviate the need for extensive medical evaluations.


Our patient died two and a half months after the diagnosis was made due to sepsis caused by Staphylococcus aureus isolated in hemoculture.


We report four cases of encephalopathy coincident with elevated aluminum levels as well as one patient who developed seizures while receiving continuous bladder irrigations with alum.


BACKGROUND: It has been proposed that the innate immune system plays a central role in driving the autoimmune T-cell cascade leading to psoriasis; however, there is no direct evidence for this.


The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.


Chemotherapy in massively obese patients may be complicated by difficulty in calculating body surface area.


A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.


Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.


Eleven of those patients also experienced clinically compromising anemia, transfusion with packed red blood cells, renal insufficiency, dialysis, or death.


The development of a rifampin-impregnated silicone catheter yielded excellent results in infection prevention and treatment in vitro as well as in an animal model.


The impressive and significant success rate for complete resolution of verrucous lesions without subsequent scarring has shown this approach to be an effective treatment for plantar warts.


Brief report: clonazepam behavioral side effects with an individual with mental retardation.


Despite appropriate anticoagulation therapy with warfarin, echocardiography and fluoroscopy showed stuck leaflets of the prosthetic valve due to thrombosis.


The patient was reintubated and five hours later was successfully extubated without further sequelae.


The article concludes with practical recommendations for clinical practice until futher evidence regarding this association is available.


The possible underlying electrophysiological mechanisms of this phenomenon are discussed in this paper.


In this report, we present a rare case of gastro-duodenal ulcer following selective internal radiation therapy (SIRT).


Streptococcus agalactiae sepsis after transfusion of a plateletpheresis concentrate: benefit of donor evaluation.


SETTING: France.


In many patients, pericardial inflammation continues and pericardial fibrosis and calcification develop, leading to a chronic and rigid constrictive pericarditis.


The benign, self-limited nature of the color change mandates that prostaglandin E1 not be discontinued for this reason.


Avascular necrosis (osteonecrosis) occurs in Crohn's disease, but the rate of this particular complication is not known.


Psoriasis-like skin reaction in a patient with rheumatoid arthritis after sulphasalazine therapy.


Despite infusion of hypertonic saline, his serum Na was not restored to normal.


Strongyloides hyperinfection in a patient with sarcoidosis.


Invasive aspergillosis of the spine is a rare and typically occurred in terminal patients.


The patient was reluctant to resume chemotherapy for his Hodgkin's disease because of his previous presumed skin infections.


To our knowledge, four cases of interstitial pneumonitis associated with fludarabine have been reported in medical literature.


However, 3 months later he developed increased intraocular pressure and a recurrence of the cystoid macular edema.


Because a catheter-related infection was suspected, the Port-A-Cath was removed after a 10-day course of piperacillin-tazobactam.


Clinicians should be aware of the possibility that vinorelbine may cause SIADH and possibly hypokalemia.


The authors describe a case of neuroleptic malignant syndrome that occurred in a patient on amitriptyline and lithium carbonate.


The arterial ketone body ratio (AKBR), which is the ratio of acetoacetate to beta-hydroxybutyrate in arterial blood and which reflects the redox state in liver mitochondria, improved dramatically following treatment.


This simple method was more efficient than intravenous therapy in ameliorating the hypophosphatemia secondary to aggressive hemodiafiltration treatment.


The patient was hospitalized and chelated with EDTA four times over the next 5 years; each time he felt better at the end of his treatment, but he returned to largely the same working conditions.


The final visual acuity was no light perception in the left eye and 3/6 in the right eye.


All eyes had subfoveal CNV secondary to AMD.


This drug has not been studied prospectively in large numbers of pregnant women and lacks the Food and Drug Administration's approval for gestational use unless benefits clearly outweigh potential fetal harm.


The dog was treated with a combination of systemic antifungals and weaning off immunosuppressants and made a complete recovery.


The patient expired from cachexia three months later.


The mechanical infusion is the easiest method to standardize and monitor.


Infection by human immunodeficiency virus (HIV) may affect joints in different ways.


We report a case of RTA secondary to FK506 administration in liver transplantation.


Had a biopsy and cultures not been done, the diagnosis of aspergillosis would have been missed and the patient might have been treated with chemotherapy, with a potentially lethal outcome.


In nine cases of botulism B infection due to food poisoning acute onset of accommodation paresis, mydriasis, and dry-eye symptoms were the prominent clinical findings.


Extensive microbiological investigation remained negative and video-assisted thoracoscopic lung biopsy demonstrated diffuse alveolar damage.


Premortem serum and postmortem tissue aluminum levels were markedly elevated.


Candida chorioamnionitis after serial therapeutic amniocenteses: a possible association.


Nocardiosis after corticosteroid therapy for malignant thymoma.


Phenylpropanolamine-induced psychosis.


Angioedema and maculopapular eruptions associated with carbamazepine administration.


Transient bullous dermolysis of the newborn does not represent an obstacle to administering appropriate chemotherapy when simple precautions are taken.


The clinical features of these nine patients combined with 15 previously reported cases were analyzed to determine factors associated with hemorrhagic worsening.


Children with acute lymphoblastic leukemia (ALL), treated with L-asparaginase are at risk for cerebral thrombosis or hemorrhage because of coagulation protein deficiencies.


RESULTS: The in vitro hemodialysis model showed that ifosfamide was cleared with an extraction ratio of 86.7+/-0.5% and remained constant even at low concentrations of drug.


As combination of chemotherapy and Gemtuzumab may become a common induction regimen for CD33+ AML patients, there is no report assessing the safety and toxicity of a re-treatment at relapse with such combination in a same patient.


Cystoid macular edema in a low-risk patient after switching from latanoprost to bimatoprost.


We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.


At the time of her first consultation at our clinic, the ultrasound examination showed a complete involution of her venous thrombosis.


The renin-angiotensin-aldosterone system appears to play an important initiating role in the pathogenesis of hypertension in patients with autosomal-dominant polycystic kidney disease (ADPKD).


If used at high dosage, it may cause a secondary form of adult hemolytic-uremic syndrome (HUS).


She has persistent proteinuria and is currently undergoing a trial of high-dose steroid therapy.


Pilocarpine toxicity and the treatment of xerostomia.


Domestic dogs and cats may be another reservoir.


These concerns may be reinforced by advice in the UK product information sheet to perform LFTs before and during treatment, by high infection rates with hepatitis C virus (HCV) among injecting heroin addicts and by the frequency of abnormal LFTs in alcohol abusers.


A trial of thrombolytic therapy with tissue plasminogen activator infusions was started at 0.1 mg/kg/hr for 6 hrs daily.


Hiccupping is a characteristic noise caused by a sudden closure of the glottis after repeated, involuntary, spasmodic contraction of the respiratory muscles.


One child showed massive cell destruction which caused hyperuricemic nephropathy.


Candida albicans shunt infection.


Here we report four cases.


We reviewed the slides of 28 brain biopsies diagnostic of PML.


Overdose of magnesium sulfate in combination with renal insufficiency, hypocalcemia, or compromise of intestinal integrity may predispose horses to magnesium toxicosis.


Drug-induced fever due to diltiazem.


RESULTS: A patient developed a bilaterally symmetric bull's-eye maculopathy 45 years after taking quinacrine for 18 months as prophylaxis against malaria.


We discuss this case and issues arising from it related to the use of CD34+ selected stem cells for transplantation.


This regimen led to a significant and long-lasting reduction of proteinuria.


A reduction of up to 33 percent in pituitary tumor size has been reported in more than half of the 27 cases studied from four groups.


His diarrhea, consisting of 10 to 12 loose stools a day, had continued for approximately two weeks and was accompanied with abdominal cramping, fever, anorexia, and weight loss.


The image illustrates the rash seen with this drug reaction.


Valproic acid induced coma is presented in an adult patient without a history of metabolic disease.


The neurological manifestations developed within one week after the last dose of Ara-C and persisted for over 8 weeks.


The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.


Therapy-related leukemia and myelodysplastic syndrome in chronic lymphocytic leukemia.


L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage.


A 46-year-old woman was brought to the Emergency Department after being found confused and nonverbal while wandering in a field.


After 4 years in complete remission, he developed a CD20-negative T-cell-rich B-cell lymphoma (TCRBCL) presenting as multiple lung lesions.


PURPOSE: A case of carbamazepine-induced hyperammonemia is presented.


Four of the eight patients had no detectable plasma cryofibrinogen after treatment.


Two weeks following rechallenge with alendronate sodium resulted in recurrence of his scleritis.


Phenothiazine treatment and respiratory distress syndrome in a child.


In the other patient, a 78-year-old woman, Neisseria mucosa knee arthritis occurred after a single sodium hyaluronate injection.


Drug provocation test is a controlled drug treatment which aims at making diagnosis of hypersensitivity reaction to drugs.


Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.


Discontinuation of the drug resulted in total resolution of the clinical and radiologic abnormalities.


A 55-year-old woman presented an episode of acute urticaria and labial angioedema 60 minutes after ingesting 500 mg of cloxacillin for a skin abscess.


The pathogenesis of augmentation is unclear.


There were no perioperative or long-term complications of the single-pass technique.


Pancreatitis is a very rare adverse effect associated with the use of amiodarone, and only four cases of amiodarone-induced pancreatitis have been reported in literature.


Eleven days after initiation of therapy with amiodarone, the patient experienced syncope and was noted to have recurrent episodes of polymorphous ventricular tachycardia.


Cholestatic hepatitis after administration of furan derivatives.


Physical examination revealed a healthy appearance of the palms; however, 5 min after immersion of the hands in warm water, the central part of the left palm became swollen and tiny white papules with dilated puncta appeared.


Endometrial squamous metaplasia.


We review the medical literature about mucormycosis peritonitis which, albeit rare, carries very high mortality.


Corticosteroid therapy was continued, but azathioprine was stopped after diagnosis.


Treatment is mainly discontinuation of the drug, however, corticosteroid therapy is recommended for severe reactions.


Four weeks earlier she had developed hepatopathy during a regimen of carbamazepine, lynestrenol and sodium valproate.


Clinical resolution was achieved with granulocyte colony-stimulating factor and amphotericin B administration.


Agitation includes combativeness, hyperactivity, disinhibition, wandering, and restlessness.


In that case, as well as the one reported here, hepatitis symptoms occurred after completion of long-term treatment in patients who were asymptomatic both before and during therapy.


Probable enoxaparin-induced hepatotoxicity.


From these data, acute generalized dystonia with brainstem and thalamic lesions may occur in WD patients after an initial d-penicillamine therapy.


She initially presented with pelvic and lower back pain, and imaging showed a pelvic deep venous thrombosis (DVT) and an interrupted IVC.


There was a dramatic increase in cardiac output 20 minutes after LS infusion, and weaning from cardiopulmonary bypass circulation was achieved.


The process is classified as a nonvasculitic pustular bacterid, and as a prototype for antigen localization of lesions to the occluded epidermal sweat duct unit.


Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.


The discontinuation of HAART led to the complete resolution of signs and symptoms.


Both PAN and methotrexate have been independently demonstrated to cause sensorineural hearing loss.


Torsades de pointes were preceded and associated with marked QT prolongation and bradycardia.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.


Acanthamoeba keratitis.


For this goal, a moist environment may be the optimal choice for topical therapy.


The cutaneous lesion consisted of an erythematous and scaly plaque on the leg measuring 2 x 2 cm.


The possibility that a higher incidence of adverse events occurs in a vulnerable population has not been systematically addressed, and seems called for.


Our experience with the two cases reported here has led us to propose guidelines for the treatment of initial PTE in a pediatric hematology unit.


QTc interval was measured before and after intervention.


A causal relationship of phrenal neuropathy with adalimumab is herein discussed.


Overnight sleep studies and multiple sleep latency testing were carried out under double-blind administration of either L-dopa or placebo.


The case history of a 42 year old male on CAPD who was receiving sodium nitroprusside (SNP) for hypertensive encephalopathy is described.


We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).


According to the Naranjo probability scale, the relationship of gemcitabine treatment with cutaneous eruption in our patient is possible.


CASE SUMMARY: A 71-year-old woman visited a psychiatrist in September 2007 for her depressed mood.


DPD deficiency follows an autosomal recessive pattern of inheritance, and its prevalence is estimated to be 3%.


Besides, failure to thrive, increased bone fragility resulting in frequent fractures and recurrent bone infections are the other characteristic features.


This severe illness was likely caused by minocycline, and we speculate that minocycline may have acted as a superantigen, causing lymphocyte over-activation and massive cytokine release.


Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.


RESULTS: The patient had fungal endophthalmitis, with O. sulphureo-ochraceum present in the lens capsule.


Acanthamoeba keratitis related to cosmetic contact lenses.


We discuss the possible role of using immunomodulating agents for the treatment of this syndrome and suggest that alternative regimens should be given special consideration especially in those critical clinical situations where supportive measures appear to be unsuccessful.


This unique syndrome should be identified as a direct causal effect of paclitaxel.


Drug eruption caused by azathioprine: value of using the drug-induced lymphocytes stimulation test for diagnosis.


Seizure with single-pulse transcranial magnetic stimulation in a 35-year-old otherwise-healthy patient with bipolar disorder.


We describe the case of a 20-year-old Caucasian male affected by enteropathic (Crohn's disease) spondyloarthropathy HLA B27 negative, successfully treated with infliximab.


Propranolol: an unrecognized cause of central nervous system dysfunction in patients undergoing cardiopulmonary bypass.


The clinical aspect closely resembled classical transient global amnesia but the episode after clioquinol lasted longer (24 hours to three days) and a more or less extensive retrograde amnesia persisted permanently.


This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine.


RESULTS: Of a total of 231 patients, 13 (5.6%) developed an infection of the central venous line, with fever that was very high in some cases.


Adverse reaction in a patient with aspirin-induced asthma treated with zafirlukast.


Mycophenolate mofetil used previously in transplantation, has recently been shown to be useful in autoimmune blistering disorders.


One should therefore be aware of possible extrapyramidal side effects with olanzapine that are reduced compared to classical neuroleptic drugs but not completely eliminated.


At this time, the TSH response to TRH was normal and the patient was considered fully recovered.


Cis-retinoic acid (RA) may further increase the risk of developing BMTN.


Temporary amelioration was achieved following plasmapheresis; however, this and other measures were unsuccessful in controlling the thyrotoxicosis, which deteriorated to thyroid storm.


A second renal biopsy showed improvement of acute tubular necrosis and endocapillary proliferation and transformation of crescents into a fibrous form.


The refractive state of lesion eye was -5.5D/-1.25D x 180 degrees, and visual acuity was hand motion at 30 cm.


Generalized lichen nitidus with involvement of the palms following interferon alpha treatment.


He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.


Dilated cardiomyopathy associated with chronic overuse of an adrenaline inhaler.


Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.


Post-allogeneic haematopoietic stem cell transplantation membranous nephropathy: clinical presentation, outcome and pathogenic aspects.


Myelodysplastic syndrome in a patient with adult T-cell leukaemia.


Recent studies have reported that patients with GD are at an increased risk of developing malignancies.


Autoimmune hepatitis associated with the use of black cohosh: a case study.


A disulfiram-like reaction was noticed each time.


Eight patients over 21 months underwent a combined intravenous-intra-arterial approach.


Two months later, he was referred to Dhahran Health Center, and admitted with fever, abdominal pain, dysuria, and severe fatigue.


PURPOSE: We evaluated the in vitro hemodialysis ratio and subsequent toxicity and pharmacokinetics of ifosfamide in an anephric patient with Wilms' tumor.


Standard therapy directed at volume overload quickly cleared the pulmonary congestion, and the pregnancy progressed uneventfully to term.


A 63-year-old man with diabetes mellitus for 15 years was admitted to our hospital in 1990 because of end-stage renal failure.


A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.


The psoralen derivatives used in the study were 8-methoxypsoralen (8MOP), 3-carbethoxypsoralen (3CPs), 4,6,4'-trimethylangelicin (TMA) and 7-methyl pyridopsoralen (MPP).


Hepatotoxicity from green tea: a review of the literature and two unpublished cases.


The observation of responses in 3 patients with T315I phenotype-refractory CML or Ph-positive ALL, at doses of MK-0457 associated with no significant extramedullary toxicity, is very encouraging.


We describe three patients with long-standing seropositive rheumatoid arthritis (RA) on chronic corticosteroid therapy who experienced very early (1-6 h) mortality after the use of intravenous thrombolytic therapy for the treatment of AMI.


Milk-alkali syndrome induced by 1,25(OH)2D in a patient with hypoparathyroidism.


During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.


The authors report a case of urinary incontinence (UI) that occurred in a woman after administration of venlafaxine.


Multiple mechanisms for ciprofloxacin-induced nephrotoxicity have been proposed.


These agents are increasingly associated with infections, particularly mycobacterial infections.


PURPOSE: To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant.


Normalization of generalized retinal function and progression of maculopathy after cessation of therapy in a case of severe hydroxychloroquine retinopathy with 19 years follow-up.


Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.


Autopsy revealed that the lung/bodyweight ratio was 0.0096 (>0.015) and pulmonary hypoplasia was noted.


It can be caused by infection of the donor or by contamination of the organ during harvest, preservation and handling, or at transplantation.


This report details the pulmonary pathologic findings in four patients with rheumatoid arthritis, who developed new onset of pulmonary signs and symptoms with alveolar infiltrates temporally related to the institution of etanercept therapy.


Despite the severity of their illness, all patients but one survived.


The authors report a longitudinal case study of a woman with a history of bipolar affective disorder in which L-dopa shortened the manic-depressive cycle length when administered in a double-blind trial.


The results of an Intergroup trial, coordinated by the Southwest Oncology Group (SWOG) demonstrated markedly superior progression free and overall survival for combined chemoradiotherapy compared to radiotherapy alone.


It is known to cause dyschromatopsia, visual disturbances, and visual-field defects.


Their parents were also found to be G6PD deficient.


This case shows the difficulties in the diagnosis of CD20-negative lymphomas when the number of tumor cells is low and when they are found in a predominant T-cell context.


Although they had complex medical problems, the high serum concentrations of ampicillin at the time of seizures without their recurrence after discontinuing the antibiotic suggest that the seizures were related to the ampicillin therapy.


Multiple complications can occur as a consequence of insertion of a VAD.


The mean decrease in vivo following hemodialysis for ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide were 86.9%, 77.2%, and 36.2%, respectively.


Probable interaction between tolterodine and warfarin.


When the patient was subsequently treated by parenteral administration of Org 10172 as anticoagulant over a period of several weeks the number of platelets rapidly increased and the patient almost completely recovered.


The EEG examination, in its third attempt, revealed bilateral multiple symmetric spikes on photic stimulation.


We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx.


The patient was treated medically with conventional amphotericin during the first episode.


Hypotensive shock and angio-oedema from angiotensin II receptor blocker: a class effect in spite of tripled tryptase values.


Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.


These reactions recurred immediately after the second dose.


Soon after its introduction in 1952, chlorpromazine was noted to induce symptoms resembling Parkinson's disease.


Clinically, the data are suggestive of the need to assimilate HRT to the natural circadian cortisol rhythm and not restrict it to the active part of the day.


The advantages and disadvantages of uncontrolled case reports are reviewed using two cases of false-positive reactions to drugs as illustrative examples.


The diagnosis was suspected in the setting of a negative anion gap and only later confirmed by direct measurement of the serum bromide level.


No symptomatic hypoglycemia or sudden incapacitation occurred.


Cardiobacterium hominis endocarditis in a patient with a hypersensitivity reaction to penicillin.


Nocardia exalbida was isolated in Japan and characterized within the genus Nocardia.


Treatment was for various tumors at advanced stages, and in some patients, other anticancer drugs previously had been administered.


The relevant literature is reviewed.


The patient was treated with ethanol, then fomepizole intravenously (15, 10, then 5 mg/kg), and hemodialysis.


Imatinib mesylate therapy in patients with gastrointestinal stromal tumors and impaired liver function.


We report here our results concerning this complication which may occur in any patient with Hodgkin's disease undergoing intensive therapy.


OBJECTIVE: To report a case of rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent.


Acute psychotic reaction with visual hallucination, delusion, panic reaction and myoclonic movement of hands developed on day 3 of admission.


Previous associations with a drug or food allergy, allergic rhinitis, atopic dermatitis, and elevated IgE levels suggest an atopic predisposition in the pathogenesis of this disorder.


This case report highlights the powerful anti-natriuretic properties of GH.


INV(12) (p13q11) and dicentric chromosomes in a secondary leukaemia with basophilia.


Strongyloides hyperinfection syndrome has not been reported in lung transplant recipients.


METHODS: We retrospectively reviewed all cases of endoscopic sinus surgery performed by the senior authors at their respective institutions.


This therapy was ceased in four patients due to neutropenia (22%).


She has had no further episodes since substitution of aurothioglucose.


Donor hearts were transported from distant hospitals (Tokyo and Miyagi prefecture) and the transportation time was 1 h 33 min and 2h 4 min, respectively.


Histopathology was suggestive of a cutaneous drug eruption.


To our knowledge, no pediatric renal transplant recipient who had thyroid carcinoma or two different types of tumor has been reported in Japan.


The patient developed neurologic signs and symptoms including disorientation, oculomotor defects, ataxia and multifocal myoclonus during both attempts at HAI.


While ethambutol treatment is most commonly instituted for pulmonary tuberculosis, it is interesting to note that both of these patients had renal tuberculosis.


Hydrocortisone may decrease the incidence of mortality associated with cardiac arrhythmias in children receiving amphotericin B overdoses.


We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period.


We describe the first case of disseminated salmonellosis in a patient treated with temozolomide.


Pregancy complicated by acute myeloid leukaemia.


Unintended exposure to acyclovir early in pregnancy, which is not uncommon, may cause excessive maternal and physician anxiety.


Acute bilateral phrenic neuropathy following treatment with adalimumab.


However, complications due to renal tubular acidosis (RTA) have recently been reported.


No further deterioration in the systemic disease occurred.


While the introduction of carmustine wafers (Gliadel wafers) into the tumor resection cavity has been shown to be a beneficial therapy for malignant glioma, it is recognized that clinically significant cerebral edema is a potential adverse effect.


The most important solvents in this respect are methanol, toluene, carbon disulfide, and n-hexane.


The eruption was characterized by generalized, pruritic, eczematous dermatitis.


Laboratory investigation showed; anemia (Hb 7.7 g/dl), slightly elevated liver function tests, elevated total bilirubin, and ESR.


By now, there are no reports in literature of agranulocytosis caused by tumur necrosis factor-alpha blockers.


Radiologic findings were consistent with PI.


A wide variety of adverse central nervous system effects have been reported in association with propafenone; dizziness is the most common.


CONCLUSIONS: The administration of prostaglandin E1 to neonates can cause gastric-outlet obstruction due to antral hyperplasia.


Addition of in vivo alemtuzumab to the conditioning regimen enabled 2- or 3-locus-mismatched hematopoietic stem cell transplantation with an acceptable incidence of graft-versus-host-disease.


Bullous Pemphigoid (BP) is an autoimmune subepidermal blistering disease appearing predominantly in the elderly.


"Broken heart syndrome" after separation (from OxyContin).


Thrombolytic treatment may be affected by minor to relevant complications such as peripheral or central embolization but in our experience and according to the literature it seems much less hazardous than re-do surgery.


Amyloid deposits in the thyroid were found on fine-needle aspiration biopsy.


A report of 4 cases.


There have been few reports regarding the clinical association of DIHS with pathogens other than herpes viruses.


This is the first documented report of human infection caused by this micro-organism.


Treatment with infliximab is known to produce an increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease.


A 68-year-old man suddenly developed extensive bleeding due to severe thrombocytopenia.


Azithromycin has been shown to be beneficial in several diseases with chronic neutrophilic inflammation of the airways, such as cystic fibrosis and bronchiolitis obliterans syndrome (BOS) after lung transplantation.


OBJECTIVE: To determine the frequency of weight loss in patients treated with leflunomide for rheumatoid arthritis at an arthritis referral center.


BACKGROUND: Cutaneous manifestations of cryofibrinogenemia include purpura, ecchymosis, and ulcerations.


CASE SUMMARY: An AIDS patient experienced an exacerbation of cytomegalovirus retinitis and was treated with foscarnet.


We present a case of CMV pneumonitis in a woman with stage IV breast cancer, with brain metastases, receiving both chemotherapy and systemic corticosteroids.


However, supplementation with corticosteroids can lead to recurrence, and care should be taken when corticosteroids are being considered.


Insulin-induced cardiac failure.


The plasma concentration of pirmenol was at a subtherapeutic level and the lymphocyte stimulation test was positive in this patient.


Follow up, at six months, after stopping the course of treatment, patient was asymptomatic except for slight bilateral non-tender breast enlargement.


It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.


When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.


RESULTS: In both cases, magnetic resonance imaging demonstrated multiple small high-intensity areas in the cerebral white matter and spinal cord, while cerebrospinal fluid examination disclosed mononuclear cell increase and protein elevation including myelin basic protein, all of which simulated the features of multiple sclerosis.


In this case, immediate discontinuation of the chemotherapeutic agent apparently reversed the patient's symptoms and findings on MRI.


Two patients who initially reacted to an oral solution formulation subsequently tolerated the corn oil-based soft gelatin capsule.


In the second case, five cardiac arrests due to ventricular tachycardia and fibrillation occurred during several hours after beginning a trial of bretylium maintenance therapy for complex ventricular ectopy.


Late free-flap salvage with catheter-directed thrombolysis.


Neurologic examinations were normal in 2 and showed developmental delay of expressive language in the third.


Interferon-induced sarcoidosis is well documented.


The vasopressin was stopped, and the skin lesion progressed to bullae formation with extensive superficial erosion.


Quetiapine was assayed in biological specimens by basic extraction with n-butyl chloride and derivatized with 50 microL of MTBSTFA and separation by GC-NPD.


These four cases, with their varied presenting symptoms, clinical courses, and degree of pathology, emphasize the importance of considering toxic leukoencephalopathy as an etiology of acute neurologic deterioration following high-dose chemotherapy.


After initial parenteral vancomycin and rifampin followed by oral prystinamycin-rifampin, the patient recovered without any sequelae.


In addition, an immediate erythematous macule was observed on the photopatch test site of mequitazine directly after UV exposure which was similar to the immediate erythema noted in chlorpromazine photoallergy.


Cat-scratch disease, primarily caused by Bartonella henselae, typically presents with regional adenopathy, and the role of antibiotics in the treatment is debatable.


Nocardial brain abscess in a renal transplant recipient successfully treated with triple antimicrobials.


CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.


Continuous subcutaneous infusion was well tolerated and about 80 per cent as effective as intravenous therapy in chelating iron.


Unexpectedly high toxicity of MACOP-B in young patients with low grade lymphoma.


The relevant literature is reviewed and supports the claim that the lithium ion may be nephrotoxic.


The combinations of clinical manifestations among FMF patients are quite heterogeneous, but our American cohort did not establish any connections between individual mutations and specific clinical pictures--as is seen in other diseases like cystic fibrosis, in which distinct genotypes target certain organ systems.


We report two patients who developed intense livedo reticularis clearly related to the administration of interferon alpha 2b as an adjuvant therapy for melanoma.


Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin.


Salmonellosis in dogs with lymphosarcoma.


Physicians should remain alert to the potential hazards of chemotherapy to the central nervous system.


We report four cases of encephalopathy coincident with elevated aluminum levels as well as one patient who developed seizures while receiving continuous bladder irrigations with alum.


On day 14, itraconazole solution at a dose of 5 mg/kg was begun.


In both cases, the psychiatric disorder was safely resolved with electroconvulsive therapy (ECT) during anticoagulant therapy.


Except for one episode of grade 4 leucopenia which required hospitalization and granulocyte colony-stimulating factor (GCSF) treatment, all adverse events resolved with dose reduction or dose omission.


The occurrence of neuromuscular blockade and the resulting potentiation of muscle relaxants during magnesium sulfate (MgSO4) administration is well known.


Review of the literature and report of a case following irradiation and cytostatic therapy.


A 30-year-old woman died as a result of a large Candida parapsilosis septic thrombus located on the tip of a Groshong catheter.


Both patients underwent cerebrospinal fluid shunting mainly for their hydrocephalus.


Rosaceiform eruption induced by erlotinib.


Two cases of polyarteritis nodosa and one case of pityriasis rosea-like drug eruption.


Several authors have speculated bacteraemic patient without having meningitis LP might actually cause meningitis.


Action of intracoronary nitroglycerin in refractory coronary artery spasm.


SD-OCT irregularities in the IS/OS junction were also seen in areas not detected on HVF 10-2.


This report presents a case of colon perforation which occurred 4 months after treatment with intraperitoneal chromic phosphate for stage IB ovarian papillary serous cystadenocarcinoma.


Subsequent management with topical steroids was complicated as the patient was a steroid responder and developed a markedly raised intraocular pressure that was managed with a topical anti-glaucoma agent.


Alternative methods for conversion of supraventricular tachycardia should be considered.


We caution against abrupt interruption of anticholinergics in patients with severe segmental cranial dystonia, even in those cases in which no benefit is apparent to observers.


In one patient, interferon induced hypothyroidism in the absence of pre-existing thyroid dysfunction and in the other it aggravated a pre-existing thyroid dysfunction.


In this paper, the authors report 3 cases of children under three years of age, with a presumed diagnosis of PNET/MB, who were preoperatively treated with chemotherapy consisting of high doses of carboplatin alone.


Frequent blood glucose monitoring is recommended in children on prolonged therapy with glucocorticoids.


Diagnosis was confirmed by 16S ribosomal RNA gene sequencing of bacterial colonies growing from the extracted device.


Intravenous bisphosphonates have come into increasing use to protect cancer patients from adverse boney events.


Abdominal pain deteriorated early in the course of the therapy along with the enlargement of the tumors.


RESULTS: Findings of HLA typing revealed positive reaction for B 51, Cw 3, DR 8, DR 11, DQ 3.


On MRI, the low and high signal areas near the end-plate of L5/S1 were detected by T1- and T2-weighted imaging, respectively, and an abscess was noted around the cage.


Polymyositis after propylthiouracil treatment for hyperthyroidism.


Non-nucleoside retroviral transcriptase inhibitors are known to cause hepatotoxicity.


Glucocorticoids may have many side effects, and therefore their use should always be carefully considered.


Thus, an increase in lactate concentration of the magnitude observed during alkali therapy need not indicate a worsening of the metabolic picture in lactic acidosis.


During prolonged treatment with zanamivir, a mutant virus was isolated from an immunocompromised child infected with influenza B virus.


He presented with hypokalemia and hyperchloremic non-anion-gap metabolic acidosis with a high urinary pH.


Sarcoidosis is a chronic granulomatous multisystemic disorder of unknown aetiology.


Three patients with human immunodeficiency virus (HIV) infection presented with QT, prolongation (> 440 ms) and torsades de pointes.


A 53-year-old female was admitted to hospital one hour after taking an overdose of 60 g of paracetamol and 960 mg of codeine.


Three patients with niacin-induced visual symptoms had cystoid maculopathy without leakage on fluorescein angiography, and a fourth patient with no fundus abnormality experienced cessation of visual symptoms upon discontinuation of niacin.


The most common cutaneous adverse event is an acneiform eruption, which occurs in more than 50% of cases.


Hemoglobin electrophoresis and methemoglobin reductase determinations were normal for age.


Eight patients reported a 'high'; six denied a 'high'.


It occurs more frequently in women with underlying systemic autoimmune disease and after multiple ocular procedures.


RESULTS: Three patients with histories of impotence experienced a return of sexual potency after treatment with fluoxetine.


Attenuation of drug-induced anxiety dreams and pavor nocturnus by benzodiazepines.


Insulin resistance declined with adrenal suppression and infection control, and wound healing improved dramatically.


To date, stent fractures reported have been related to aggressive post dilation.


This case extends the spectrum of fludarabine pulmonary toxicity to include pulmonary nodules.


At the time of death, leukocytes were 0.3 x 10(3)/mm(3), platelets 10 x 10(3)/mm(3), and hemoglobin 6.8 mg/dL.


Palmar-plantar erythrodysaesthesia (PPE) is an uncommon cutaneous complication of cytotoxic chemotherapy which generally presents as a painful erythema involving the palms and soles.


IVIg may reverse and stabilize the inflammatory process.


Five cases are presented that demonstrate the effectiveness of diazepam and its close relative clorazepate in controlling this problem.


Patients in whom CSC develops while using corticosteroid inhalers or nasal sprays should be alerted to the possible relationship between CSC and these agents.


Upon discontinuation of MTX, her ascites resolved, and her arthritis became more active.


CONCLUSIONS: Laser in situ keratomileusis can be complicated by Acanthamoeba infection.


In case #1, the concentrations of quetiapine found were 7.20 mg/L (19 micromol/L) in blood and 0.93 mg/L (2.4 micromol/L) in vitreous fluid.


In vitro inhibition of hematopoiesis in a patient with systemic sclerosis treated with D-penicillamine.


OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.


Six consecutive patients with HIV infection and NCPH were the subject of this series.


A 21-year-old woman suffering from bipolar affective disorder developed systemic lupus erythematosus (SLE) with characteristic laboratory findings, 18 months after starting carbamazepine maintenance treatment.


She was initially managed with palliative nephrectomy, which was followed by rapid postoperative deterioration.


Posterior leukoencephalopathy following cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary.


RESULTS: Only when the antidepressant was removed, twice, was treatment an atypical antipsychotic and lithium effective.


Patients experienced a mean reduction of 92% (a mean drop in frequency of 21.7 to 1.7 episodes per week).


Linear IgA disease (LAD) is characterized by circulating and tissue-bound IgA antibodies against heterogeneous antigens in the cutaneous basement membrane zone.


In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine.


Autologous bone marrow transplantation in relapsed HIV-related non-Hodgkin's lymphoma.


The plasma concentrations of the active metabolite M6G were more than 10 times those normally seen and the half-lives of M6G and morphine were prolonged.


Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.


She improved with administration of diazepam, but needed repetition of this treatment over the next 16 hours.


Its immunomodulatory properties, however, may allow its future use in the treatment of psoriasis.


In one case, the readministration of riluzole was followed by the relapse of hepatitis.


A mild decrease in the temperature (33.4-34.7 degrees C) along with delusions and feeling slightly chilly was part of the initial presentation.


He was referred to the psychiatry service where he was treated with olanzapine.


SMS 201-995 was also effective in suppressing thyroid-stimulating hormone (TSH) and thyroid hormone secretion in a patient with mild thyrotoxicosis due to non-tumoural inappropriate TSH hypersecretion.


The typical fluoxetine-induced symptoms of restlessness, constant pacing, purposeless movements of the feet and legs, and marked anxiety were indistinguishable from those of neuroleptic-induced akathisia.


This may be related to individual variations in cerebrospinal fluid dynamics and drug metabolism.


This unusual pattern of low-grade endometrial carcinoma adds to the spectrum of uterine neoplasia associated with tamoxifen therapy.


Generalized argyria, the systemic dissemination and tissue deposition of silver-containing particles, is characterized by slate gray discoloration of skin, most pronounced in sun exposed areas.


An increase of intoxications in persons using alkaloid-containing ornamental plants (mainly angel's trumpet) for their hallucinogenic effects and easy and cheap availability is registered.


Differentiation and treatment can be complex, especially when features of both syndromes are present and the patient has taken both serotonergic and neuroleptic agents.


Human coenurosis in North America: case reports and review.


As Paget (1988) says, "The sorrow of mistakes is sometimes very diffuse and sometimes very pointed.


Intravitreal injection of triamcinolone acetonide is useful in the treatment of macular edema; however, accumulation of triamcinolone acetonide particles on the posterior lens capsule may decrease visual acuity and requires surgical treatment.


A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.


In both cases, high fever, skin rash, liver dysfunction and atypical lymphocytosis developed 3 weeks after initiating treatment with SASP.


Physicians in the United States, especially those who practice primary care, hematology/oncology, and infectious diseases, must be aware of the availability and use of metamizole in specific patient populations and its potential for harmful side effects.


An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.


After exclusion of common reasons of this condition, liver biopsy was performed.


Nocardiosis revealed by thyroid abscess in a liver--kidney transplant recipient.


Subfoveal choroidal neovascularization in a patient with hemicentral vein occlusion.


Her IFN beta-1a was discontinued and intravenous immunoglobulin therapy was started for her scleromyxedema.


We observed a 7.0% prevalence of QT, prolongation among all patients screened.


Both serum hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (HBsAb) were negative on admission.


They were both treated for stage IV neuroblastoma with chemotherapy, bone marrow transplant (BMT) conditioning that included total body irradiation and RA therapy after BMT, although the patient in case 1 had established renal insufficiency prior to the commencement of RA.


Initially, she responded well to corticosteroids, but relapsed when medication was discontinued.


Patient A reported right leg weakness (foot drop) during week 4 of CAP-XRT (1600 mg/m2).


Antibiotic treatment did not stop the progress of the disease.


The most frequent pathological finding is myocardial haemorrhage, with no evidence of coronary artery atheroma or thrombosis.


Biological data mainly revealed hepatic failure and lactic acidosis.


METHODS: Three infants were treated with clobetasol propionate (Temovate) cream for vision-threatening eyelid hemangiomas.


Lichen nitidus is an uncommon dermatosis of unknown etiology.


Transrectal ultrasound-guided needle biopsy of the prostate is a widely accepted technique to obtain prostatic tissue for histological examination.


We present a severe case of TPP in a 22-year-old Latino male with rapidly progressive ascending paralysis and hypokalemia severe enough to lead to cardiac arrest.


Histological changes after the use of mycophenolate mofetil in autoimmune hepatitis.


She subsequently underwent successful cardiac transplantation.


Physician awareness of the occurrence of a variety of muscle disorders including polymyositis in thyroid disease is emphasised.


However, there was clinical and electrophysiologic recovery after initiation of intravenous immunoglobulin (IVIg) therapy.


We present a patient with typical aquagenic pruritus who responded well to PUVA, and who has remained well controlled on infrequent maintenance.


Acute endophthalmitis following intravitreal bevacizumab (Avastin) injection.


To know the histochemical effects of steroid treatment on eosinophil accumulation in nasal polyps of AIA and the histochemical feature of a recurring polyp and to detect distributional differences between storage and secreted forms of eosinophil cationic proteins, we carried out immunocytochemical labelling with antibodies against EGI (recognizing resting and activated eosinophils) and EG2 (recognizing only activated eosinophils), and determined eosinophil infiltration in nasal polyps that were obtained before and after steroid treatment, and at recurrence of polyps.


Five patients were treated with isoprinosine and the antiepileptic drug valproic acid.


Maintaining a high index of suspicion with early recognition and aggressive therapy may decrease the morbidity and mortality of this devastating and life-threatening infection in the compromised host.


These effects are mainly due to the thrombolysis of macroscopic blood clots and the amelioration of microcirculatory reperfusion.


After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.


Patients did not show any local recurrence after 1 year.


Clinicians should be aware of the possibility that vinorelbine may cause SIADH and possibly hypokalemia.


Kluyvera species are opportunistic, gram-negative bacilli in the family Enterobacteriaceae.


Reports of colonic perforation as a result of the administration of calcium polystyrene sulfonate and sorbitol are rare.


RESULTS: Histopathology revealed a subcorneal blister with prominent neutrophilic infiltration.


Anticoagulation was maintained and the prognosis remained good.


All 3 patients received rituximab according to a standardized institutional rate schedule, and all received pre-medication with acetaminophen and diphenhydramine.


Portal vein thrombosis during antineoplastic chemotherapy in children: report of five cases and review of the literature.


PURPOSE: To report the clinical course, management, and outcome of infectious interface keratitis caused by mycobacterium species after laser in situ keratomileusis (LASIK).


AIM: Report of a case of a woman patient who developed celiac disease after pegylated interferon alpha-2a and ribavirin use for chronic hepatitis C.


The oral mucosa, tongue, sclera, and conjunctiva also had a slightly blue-gray discoloration.


Pharmacokinetics of daptomycin in a critically ill adolescent with vancomycin-resistant enterococcal endocarditis.


Upper tract urothelial malignancy after cyclophosphamide therapy: a case report and literature review.


It should be considered for use before benzoin because once allergy to benzoin exists, cross-reactions to Mastisol usually occur.


During the treatment of hematological malignancies this could be a cause of great concern.


An awareness of this potential complication is important when treating children with aspirin at doses previously considered to be non-toxic.


Gold and sulfur could not be demonstrated in glomerular epimembranous deposits.


Vincristine levels were also assayed and showed a dramatic decline in postexchange levels in the 2 patients who survived and an almost unchanged value in the patient who succumbed.


Initial presentation was adnexial mass and chronic pelvic pain.


Clinicians need to be aware of this rare but potentially fatal side effect in patients of all ages, and especially in adolescents receiving both drugs.


Clinical observations were examined retrospectively for three cases with adverse reactions and cited to support a dynamic theory that associated drug reactivity to personality factors.


Discontinuation of levamisole and 5-FU for a five-week period resulted in the INR falling to a subtherapeutic level.


A drug-drug interaction may result in decreased methadone blood levels when administered with nevirapine.


METHODS: Ten patients with long standing primary CBCL (3 with follicular CBCL, 5 with cutaneous, large B-cell lymphoma, 1 with diffuse large cell lymphoma, and 1 with extranodal large cell lymphoma) were treated by intravenous application of a chimeric antibody against the CD20 transmembrane antigen that is present on malignant and normal B-cells.


A case of barbiturate-induced submassive hepatic necrosis is presented and the literature is reviewed.


A 48-year-old woman with multiple myeloma, developed progressive neurological disturbances one year after the bone marrow remission.


A 12 year old patient with atrial flutter is presented, in whom intravenous adenosine was followed by acceleration of the heart rate to a potentially dangerous arrhythmia.


Treatment for 1 year or longer decreased tumor secretion of gastrin and diminished basal acid secretion, an effect that persisted for 48 hours after withdrawal of SMS.


When side effects recurred the dosage was reduced further by 50%.


Myoclonus is a movement disorder of various etiologies.


This entity is probably related to a combination of high doses of corticosteroids, vecuronium administration and metabolic abnormalities associated with respiratory failure.


Neither mosaic perfusion nor air-trapping was seen in HRCT on inspiration and expiration.


In this healthy population, the relative risk of developing endometrial carcinoma in the tamoxifen arm was 2.54, although when stratified by age, in women over 50, the risk grew to 4.01.


No organisms could be grown by culture of corneal scrapings for bacteria and fungi, and the condition failed to respond to topical therapy.


Endocrine physicians should be alert to this in patients with fixed DI and an abnormal thirst threshold.


Recurrent aortic valve prosthesis dehiscence secondary to aortoarteritis: three case reports and literature review.


It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible.


Conversely, diffuse interstitial pulmonary fibrosis should be considered in the differential diagnosis of patients receiving methotrexate who develop bilateral pulmonary infiltrates seen on chest roentgenograms.


We report a case in which in-stent restenosis of an overhanging stent had been treated with an also overhanging sirolimus-coated Cypher stent (Cordis Corporation, Roden, The Netherlands).


Two years after HSCT, the patient developed nephrotic syndrome.


CONCLUSIONS: As a result of recent tyramine analyses and 2 well-documented case reports, all tap (draft) beers should now be absolutely restricted on MAOI diets because they represent a very significant risk at modest levels of consumption.


Hepatitis C (HCV) treatment using interferon-alpha (IFN-alpha) and ribavirin is recommended in HIV/HCV co-infected patients to prevent liver cirrhosis and liver-related death.


Prior to surgery, levodopa induced dyskinesia had improved (< or = 50%) under treatment with amantadine (400 mg/day, po) in all three patients.


Continuous high-dose intracoronary nitroglycerin infusion in refractory coronary vasospasm.


Acute coronary syndrome induced by capecitabine therapy.


She was treated with intramuscular injections of methotrexate 20 mg/wk.


In an effort to destroy verrucous growth, the authors have attempted to alter the genetic structure of these obstinate, benign warty lesions by using the antibiotic, bleomycin sulfate.


Posterior leukoencephalopathy following intrathecal chemotherapy with MRA-documented vasospasm.


All 4 patients who were recruited completed the procedure successfully without significant difficulty.


Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or "cutting" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.


Oxaliplatin is a new platinum derivative that has significant activity in patients with metastatic colorectal carcinoma.


At the bedside, nurses play a pivotal role in early recognition and treatment, the key to survival.


In addition, she required additive reductions of 33-42% in her weekly warfarin dose with each chemotherapy cycle to maintain a therapeutic INR (goal range 2.0-3.0).


The findings are based on liver histology and the exclusion of other causes of liver damage.


Benzocaine, an ester-type local anesthetic, was believed responsible for apparent methemoglobinemia in a cat.


CASE SUMMARY: An elderly patient with chronic atrial fibrillation and prosthetic valve replacements had been taking warfarin 22.5 mg/wk.


Liver function tests (LFT) returned to normal within five days of hospitalization but she continued to develop daily fevers.


Flumazenil reversal of benzodiazepine-induced sedation for a patient with severe pre-ECT anxiety.


We describe a case of disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci) induced by praziquantel therapy, an event not described previously.