Two patients with Parkinson's disease with pedunculopontine nucleus (PPN) stimulation for gait impairments reported "trembling vision" during the setting of the electrical parameters, although there was no clinically observable abnormal eye movement.


Efficacy, cost, toxicity, and duration of treatment determine a treatment protocol.


All patients were in a group with an expected mortality rate of 90-100%, based on previous studies.


Three patients (APML = 1 and ALL = 2) are still alive and disease-free.


Anti-platelet therapy with clopidogrel has been shown to reduce both acute and chronic events in patients with NSTE ACS, including patients undergoing PCI.


Uveitis associated with rifabutin therapy: a clinical alert.


Herein, we report a patient treated preoperatively with multiple psychiatric medications who developed serotonin syndrome (SS) during the perioperative period.


The average length of clinical follow-up was 6 months (range 1-13 months).


In this group, four men were seen with osteonecrosis.


Pseudomembranous colitis readily occurs in at least certain population groups receiving trimethoprim-sulfamethoxazole.


Mitomycin C-related hemolytic uremic syndrome in cancer patients.


We suggest that nicotinic acid was the cause of his liver disease, that this case is of particular note because of the rather short period of therapy before the onset of liver injury and the severity of the hepatic failure, and that the probable increased use of nicotinic acid for serum cholesterol control makes it especially important for physicians and their patients to be alert to the signs of hepatotoxicity.


Side effects such as acute renal failure, hyperkalemia, gastritis, gastrointestinal bleeding, and asthmatic exacerbation, although rare, have been previously reported.


Laboratory data showed hypernatremia with increased plasma osmolality and metabolic hyperchloremic acidosis.


Hypersensitivity reactions involving the kidneys can occur with any of the penicillin groups.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


However, viral tests had remained positive for 8-39 days.


There are very few reports about asterixis as a side effect of treatment with psychopharmacologic agents.


This case extends the spectrum of fludarabine pulmonary toxicity to include pulmonary nodules.


A total of 24 patients were identified and clinical information of varying detail was available in all cases.


Successful treatment of disseminated Fusarium infection after autologous bone marrow transplantation for acute myeloid leukemia.


Treatment with oral prednisolone resulted in some improvement in the cutaneous signs, particularly over the face, trunk and proximal limbs.


After an extensive review of the literature, we believe that this is the first communication of the successful use of amiodarone to control hyperthyroidism in a patient with PTU-induced fulminant hepatitis.


Aspergillus fumigatus keratitis following laser in situ keratomileusis.


The fever abated promptly following discontinuation of acyclovir, and radiographic abnormalities resolved over ten days.


We observed a decrease in nocturia frequency in all three patients, a decrease in irritative urinary symptoms in two and an improvement of sleep QOL in two.


Histologically confirmed lymphoma with evidence of active EBV proliferation developed within cervical lymph nodes 3 weeks after his first autologous stem cell rescue.


Toxicities included fever, skin rash, somnolence and a generalized seizure.


An apparent link is described between the use of MMF with prednisone to treat pemphigus vulgaris and the development of red blood cell anemia.


Reports in the literature of isolated agranulocytosis are few, although they may be associated with significant morbidity and mortality.


Our series of 3 patients supports a causal connection between bleomycin and scleroderma.


A seven-year-old boy with acute lymphoblastic leukemia received vincristine sulphate 1 mg, 1 ml intramuscularly, into his glutea, inadvertently, in the local hospital.


CONCLUSIONS: Continuous infusion of local anesthetic and opioid to a sternal fracture site using a periosteally positioned catheter led to successful analgesia and hence improved respiratory function.


IMPLICATIONS FOR NURSING PRACTICE: With any new treatment option, it is imperative that nurses understand how agents work to enrich their own knowledge base, as well as have a strong foundation for patient education.


According to the Naranjo probability scale, this reaction was probable.


Esmolol, an ultrashort-acting beta 1-selective antagonist, controlled her multiple dysrhythmias and symptoms of sympathetic nervous system hyperstimulation.


She was successfully treated with oral prednisolone and cyclosporine A (CsA).


A good partial remission was attained.


The beta-lactam antibiotics are reported to induce convulsions caused by the suppression of inhibitory GABAergic functions.


Treatment with topical and intracameral amphotericin B and systemic fluconazole, along with topical corticosteroids and intracameral t-PA, was successful in eradicating the corneal infiltrate and resolving intraocular inflammation.


However, follow-up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance.


Infants, particularly neonates, are not merely small adults requiring smaller dosages, but rather uniquely different patients.


A 31 year old woman presented with a chest wall abscess due to Actinomyces israellii and Porphyromonas asaccharolytica (previously Bacteroides asaccharolyticus).


Our institution has also adopted a similar combined therapy protocol for patients with stage III and IV nasopharyngeal cancer and good performance status.


One month after surgery both patients were free of involuntary movements with an improvement of about 60% in the "off" state UPDRS motor score.


RESULTS: Quetiapine was associated with leucopenia in two patients and clinically apparent agranulocytosis in one patient.


A rare case of upbeating nystagmus, which occurred under the condition of a loss of visual fixation, due to anticonvulsant intoxication is reported.


Extensive pelvic, pulmonary and brain metastases were associated with clinically manifest thyrotoxicosis.


The patient had recurrence of urticaria and angioedema a year and a half later, at which point the NPH was stopped and she was desensitized to regular insulin.


A renal biopsy showed diffuse mesangial proliferation with marked glomerular infiltration of macrophages and massive subendothelial and mesangial deposits.


The long-term therapy necessary to eradicate the Mycobacterium tuberculosis organism makes economic considerations important.


Etanercept and demyelinating disease in a patient with psoriasis.


PURPOSE: Quetiapine is a novel antipsychotic, which is efficacious in the treatment of positive and negative symptoms in schizophrenia.


Ramipril therapy resulted in an important reduction of proteinuria (0.3-0.5 g/24 h): no changes were observed in arterial pressure and renal function during the 12-month follow-up.


Electrophysiologic data obtained before and during thyroxine replacement therapy showed that hypothyroidism lengthens the effective refractory period of the atria, AV node, bypass tract and His-Purkinje system (that in the ventricle not being measured); this lengthening resembles the effects of long-term administration of amiodarone.


A patient presented with a painful, oedematous, cyanosed hand having injected a solution of diamorphine and methylphenidate into his radial artery.


Any areas of obvious third-degree burns would be debrided and grafted.


The patient developed a raised purple area of discoloration around the intravenous insertion site within 2 h and edema and vesiculobullous lesions of the distal forearm, hands, and fingers within 8 h.


The patient's autoimmune thyroiditis may also contribute to the predisposition for pemphigus development.


Twenty-four months after patient's discharge, her clinical condition, CBC, and bone marrow remained normal.


Calotropis procera (ushaar) keratitis.


A 32-year-old man with a family history of type 2 diabetes mellitus presented with circulatory collapse and deep coma after 9 days of treatment with perospirone hydrochloride, a recently developed atypical antipsychotic agent available only in Japan.


The use of a plant fungicide, the imidazole imazalil, in the therapy of human alternariosis is described.


Two of our patients had failed treatment with haloperidol and another had failed treatment with pimozide.


No clinical side-effects or evidence of systemic activation of coagulation occurred during the treatment.


OBJECTIVE: The aim of this study is to describe the efficacy and safety of risperidone, in the treatment of delusions of infestation.


In contrast to that in other nephropathies, the role of renin-angiotensin blockade in kidney transplantation is less well defined, and its anti-proteinuric effect is markedly reduced in the presence of segmental glomerulosclerosis.


However, the sphincterotomy did not improve cholestasis.


These data indicate that the current methods for monitoring resistant mutants are potentially flawed because no tissue culture system adequately reflects the receptor specificity of human respiratory tract epithelium.


Intracameral tPA injection resulted in complete resolution of hyphema in all 3 eyes.


Arterial occlusion due to intraplaque hemorrhage and de novo thrombosis caused by thrombin-mediated platelet aggregation are also discussed as potential mechanisms of arterial occlusion.


A review of the literature reveals this as a unique case.


A 64 year old woman with previous history of coronary stenting five days before was admitted in our institution for intracranial bleeding while receiving aspirin and clopidogrel.


Myeloma screen was negative; ANC >1,000 at day +7, platelets >50,000 at day +24.


However, the use of atypical neuroleptics in modern psychopharmacotherapy is increasing, so the incidence of NMS under these drugs may also increase.


Histologic examination of skin biopsy specimens from the patients' UV-B and UV-A test sites and lesional skin revealed an acute eczematous dermatitis.


Administration of steroid and decreasing the dose of PTU produced a good clinical response and the ANCA disappeared.


The diagnosis of pseudomembranous colitis was made by flexible sigmoidoscopy and a positive stool specimen for Clostridium difficile toxin.


Quetiapine-induced leucopenia and thrombocytopenia.


However, since maternal death has occurred with postpartum vulvar edema, the patient with vulvar edema merits special attention.


Because pain perception involves both serotonergic and noradrenergic mechanisms, venlafaxine also may be useful in neuropathic pain therapy.


This case is unique in that interstitial lung disease evolved in parallel with colitis and caused severe hypoxemia.


Intracavernous self-injection with vasoactive drugs is a new treatment for impotence.


RESULTS: The patient's serum from 10 days after the episode, only when therapeutic concentrations of oxaliplatin were added, reacted with all RBCs tested using the indirect antiglobulin test (IAT) (3+).


The attending or consulting physicians assessed that acute hemolysis or DIC caused or contributed to each death.


The ocular motor disturbances are probably an expression of regional 5-FU neurotoxicity primarily affecting the brain stem.


From the literature, 72 references were reviewed.


Fifty days after the first UCBT, the patient underwent a second UCBT with a reduced-intensity conditioning regimen.


A patient with biventricular thrombus formation in dilated cardiomyopathy suffered massive combined systemic and pulmonary embolization shortly after oral anticoagulation was started.


An unusual case of Ecstasy poisoning.


Potential advantages and disadvantages of using epinephrine in this setting, the role of alpha-agonists and some potential mechanisms accounting for their role in successful management are reviewed.


Patients finally rated their subjective impression on this intervention.


Clinical responses were noted within 3 to 7 days of initiation of treatment.


Respiratory failure in Wegener's granulomatosis: response to pulse intravenous methylprednisolone and cyclophosphamide.


This complication was dose related and argues for caution when initiating intrathecal therapy with amphotericin B at doses greater than 0.025 mg.


We describe 2 patients with prior amputation who experienced phantom limb pain (PLP) after receiving paclitaxel therapy.


The case history and toxicological findings of an infant fatality involving pseudoephedrine, brompheniramine, and dextromethorphan are presented.


Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide.


The distinctive histopathological findings led to the correct diagnosis despite sparse clinical information.


This is an important pitfall because, when diagnosed early, bleeding in these patients is treatable.


Two patients underwent penetrating keratoplasty at 22 and 26 months after the onset of symptoms and have maintained clear grafts with no evidence of recurrence.


The literature, except for anecdotal reports, does not support a significant increase of ulcers in asthmatic patients on either theophylline or steroids.


Hypertensive reactions occurred without obvious cause in two patients receiving monoamine oxidase inhibitors (MAOIs) while being monitored in a hospital.


CONCLUSION: This case highlights the importance of timely application of aggressive measures even in patients with known diagnosis of a fatal malignancy as these interventions can prolong life and be of palliative benefit.


We report a case of AILD in an 80-year-old male who presented with a generalized pruritic maculopapular eruption and fever following doxycycline administration.


The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.


A case of cicatricial pemphigoid with circulating IgA and IgG antibodies directed against 280 kD, 165 kD and 120-130 kD epidermal antigens.


A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.


No published reports, however, exist of exfoliative disease after treatment with levofloxacin.


METHOD: The authors followed a patient with chronic HCV who received interferon and ribavirin and who developed hallucinations ultimately requiring psychiatric hospitalization.


Striking regression of radiation-induced fibrosis by a combination of pentoxifylline and tocopherol.


Ovadendron sulphureo-ochraceum endophthalmitis after cataract surgery.


The persistent effects of methotrimeprazine meleate on various organs are typical of the prolonged biological action of the phenothiazine metabolites.


CONCLUSIONS: We believe this case to be the first report of this type of reaction owing to tadalafil.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


Interaction of the criminal justice system and psychiatric professionals in which civil commitment standards are prohibitive.


Gangrene of the fingertips after bleomycin and methotrexate.


Special attention should be paid when attempting to sample the endometrium in patients with mullerian abnormalities.


We believe the temporal association of the abnormal liver enzymes in this patient, in the absence of other offending agents, argues strongly in favor of 6-TG as a cause of liver enzyme abnormalities.


A case of a 36-year-old man who presented with monomorphic ventricular tachycardia 12 years following a myocardial infarction that occurred during his last course of bleomycin-etoposide-cisplatin therapy for testicular cancer is reported.


Clinical recovery followed discontinuation of therapy and paralleled EEG resolution.


Propranolol had to be given for eight months after surgery.


Thereafter, sixteen cycles of immunoglobulin treatment (400 mg/kg) along with corticosteroids were instituted and led to an improvement in subjective symptoms with decreases in level of CPK and LDH.


We suggest that LS enhances cardiac performance during and after cardiopulmonary bypass, and can be useful for patients who are unable to be weaned from cardiopulmonary bypass.


Elevation of muscle enzymes and electromyography were compatible with myopathy.


Patients receiving therapeutic immunosuppression for organ transplants have also reported to suffer from aspergillus osteoarthritis.


These cases illustrate that the assumption that this drugs is without significant adverse effects may be unwarranted, especially for children and adolescents with chronic diseases.


Improvements in quality of life following treatment with r-HuEPO in anemic hemodialysis patients.


Ganciclovir and standard high-dose immunoglobulins for the treatment of cytomegalovirus interstitial pneumonia in a bone marrow recipient.


46-year-old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon beta-1b subcutaneously for multiple sclerosis.


Serious allergic reactions related to Increlex therapy have not been reported.


Endoscopic examination demonstrated severe erosive gastritis and duodenitis, and histological examination of the antral tissue showed severe atypia and histological appearances suggestive of in situ carcinoma.


The features of neuroleptic malignant syndrome are reviewed with a differential diagnosis of myoglobin renal casts.


Herein, we present a patient with severe and prolonged hypoglycemia after long-acting octreotide treatment.


Superior mesenteric vein thrombosis persisted, with evidence of early vascular recanalization.


Resection and use of a cyclooxygenase-2 inhibitor for treatment of pancreatic adenocarcinoma in a cockatiel.


Postural epigastric pain as a sign of cytomegalovirus gastritis in renal transplant recipients: a case-based review.


Much of this tone reflects abnormal vascular function, characterized by impaired prostacyclin and EDRF effects, in conjunction with increased vasoconstriction due to endothelin and possibly other factors.


RESULTS: A 13-year-old boy with cryptogenic liver cirrhosis received an orthotopic liver transplant from a deceased donor.


Aggressive chemotherapy, organ-preserving surgery, and high-dose-rate remote brachytherapy in the treatment of rhabdomyosarcoma in infants and young children.


We report a rare case of colonic mucosal necrosis following Kalimate (calcium polystryrene sulfonate), an analogue of Kayexalate without sorbitol in a 34-yr-old man.


Docetaxel-induced Meibomian duct inflammation and blockage leading to chalazion formation.


CONCLUSION: Although a definite association has not been proven, clinicians should be aware of the possibility of agranulocytosis while using quetiapine.


Only rarely has involvement of the left-heart been documented.


University teaching hospital.


He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.


We present findings from three patients who experienced a psoriasiform eruption apparently due to the antiepileptic agents sodium valproate and carbamazepine.


Other possible causes of hepatotoxicity were excluded.


Combined ketoconazole and amphotericin B treatment of acute disseminated histoplasmosis in a renal allograft recipient.


These later regressed when the drug was withdrawn.


Patients taking these drugs, therefore, often felt that the treatment was making them worse instead of better, and were reluctant to continue with it.


Clinical guidelines for the use of clonidine in particular and the use of polypharmacy in general are presented.


Disulfiram encephalopathy as a cause of the catatonia syndrome.


This report suggests that anemia can occur due to MMF, in particular when it is given with prednisone, a side effect well documented in the transplantation literature when the triple combination of MMF, cyclosporine and prednisone is used.


The mean age of these patients was 16 years (range 4-63), and 90 were aged 15 years or younger.


None of the patients had experienced visual hallucinations before this event.


There is growing interest in the use of hyperbaric oxygen therapy (HBO(2)) for children with cerebral palsy.


A 34-year-old woman presented to the out-patient clinic with angioedema and type II hereditary angioedema was confirmed immunologically.


Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males.


During hospitalization the patient developed hemolytic anemia (Coombs positive) and lung metastases.


The patient was treated with cholesterol-lowering agents (i.e., cholestyramine, lovastatin).


Fortunately, a hypersensitivity reaction to one formulation of cyclosporine does not preclude use of a different formulation.


Valvular heart disease in a patient taking benfluorex.


A patient developed DIHS during treatment with diaminodiphenylsulphone for pemphigus foliaceus.


Increased neurotoxicity was not observed in any child.


The clinical improvement and decreasing in muscle enzyme level occurred after colchicine withdrawal.


The infection was successfully managed with liposomal amphotericin B and functional endoscopic sinus surgery.


The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.


Although patients have the opportunity to report ADRs in several countries, little is published in the literature about the contribution that patient reports have in practice.


With higher doses of radiation being given by using conformal techniques, more radiation-induced optic neuritis and neuropathy will be identified.


The development of new pharmacological agents with varied properties and actions has increased the risk of serotonin syndrome as a clinical diagnosis.


This study reports Mycobacterium bovis (BCG strain) dissemination in four primary immunodeficient (PID) patients.


The psychotic reaction was thought to be due to steroid therapy since no other causes could explain the psychotic reaction.


Intrathecal administration of rituximab may be a feasible approach in children with PTLD in the CNS.


He had a history of subtotal gastrectomy.


The patient recovered from renal failure and no other side effects were observed.


On arrival in the hospital 1 hour later, she complained of muscle pain and tiredness.


Occasionally, parasites are noted in the sputum.


We will also discuss other potential mechanisms inducing this disturbance and its differential diagnoses.


Jude Medical mitral valve prosthesis.


No complications of the intravitreal injections were noted.


We think that our case was a new late pulmonary complication after UCBT.


Effects on heart rate and blood pressure as well as tachyarrhythmias have been well described.


Cutaneous lesions resolved two weeks after the drug was withdrawn and topical steroid treatment was instituted.


Fluphenazine-induced neuroleptic malignant syndrome in a schizophrenic patient.


Baseline examination and investigations were performed, including fundus fluorescein angiography, and the patients were given a single intravitreal injection of triamcinolone (4 mg/0.1 mL).


Treatment of JHR is largely supportive, such as administering antipyretic and antiinflammatory agents.


Severe maternal bradycardia and asystole after combined spinal-epidural labor analgesia in a morbidly obese parturient.


The possible development of a drug-induced vasculitis or lupus-like syndrome should be added to the list of rare toxic effects of vancomycin.


METHODS: A fully alert 83-year-old woman with disciform scar right eye (OD) and occult choroidal neovascularization (CNV) left eye (OS) experienced a progressive visual loss to 20/800 OD and 20/400 OS.


Massive pulmonary embolism complicating streptokinase treatment for deep vein thrombosis.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


Fatal toxic epidermal necrolysis related to lamotrigine administration.


Pemphigus foliaceus was seen in a patient with pulmonary tuberculosis during rifampicin therapy.


Post-steroid septic arthritis can be treated with irrigation pump assisted arthroscopic synovectomy.


While 40 mg/day of prednisolone improved hepatic dysfunction dramatically, her diabetic milieu deteriorated seriously.


To date, little evidence exists that these drugs are oncogenic.


A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds, admitted for a manic episode and treated with levomepromazine, diazepam and lithium carbonate.


In all cases lithium levels were between .75 and 1.7 mEq/liter.


Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.


Pulses have been given for periods up to three years without evident toxicity.


Myoglobinuria and acute renal failure associated with intravenous vasopressin infusion.


The second episode ended when lamivudine dosage was reduced.


The electrocardiogram (ECG), which was read as normal prior to ritodrine infusion, demonstrated a type I second-degree AV block which disappeared upon discontinuation of ritodrine therapy.


A case of severe aplastic anemia secondary to treatment with lenalidomide for multiple myeloma.


The authors hypothesize that inhibition of glucuronidation is responsible.


With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.


Hemodialysis was also shown to reverse ifosfamide-related neurotoxicity.


BOOP is mainly treated with corticosteroids, which induce a rapid clinical improvement.


A woman developed delusional parasitosis when taking phenelzine.


We describe a 15-year-old female patient diagnosed with acute lymphoblastic leukemia presenting with status epilepticus after receiving intrathecal methotrexate.


We report the clinical and pathological findings of an unusual invasive fungal infection in a 13-year-old girl with T-NHL.


A 57-year-old man with nodular rheumatoid arthritis was started on a combination of etanercept and methotrexate.


Native arterial thrombosis, though recognized as a severe complication of thrombin injection, has not been well described in the literature.


Despite the significant weight loss, 4 of the 5 patients continued to take the drug due to its efficacy.


Immune tolerance in a haemophilia A patient with high inhibitor using locally prepared lyophilized cryoprecipitate.


Although the blood pressure remained normotensive, renal biopsy showed thrombosis of the polar arterioles and glomerular capillaries.


BACKGROUND: There has been discussion about the acceptance of adverse drug reactions (ADRs) reported by patients to spontaneous reporting systems.


The patient required high dose opioid to control the shoulder pain.


In view of her cachexia and cytopaenia, emergency chemotherapy was initiated using a modified regimen of carboplatin, etoposide and vincristine (CEO) in preference to the more traditional but less well-tolerated VAC (vincristine, actinomycin D, cyclophosphamide).


The preclinical activity profile combined with the hematological toxicity data in rodents and the water solubility of the compound compare favorably with MMC.


Once her blood pressure stabilized, the patient improved clinically.


RESULTS: The patient was treated with aggressive hydration, allopurinol, and repeated hemodialysis.


They discuss this underrecognized complication of valproate use and the implications for treating elderly patients, in whom valproate use is increasing.


Cholesterol microembolization as a sequela of oral anticoagulant therapy has been reported to cause infarction of virtually any organ, often resulting in death.


A ventilation-perfusion lung scan showed no defects; roentgenograms showed bilateral infiltrates and a left-sided pleural effusion.


Approximately 4% of his body surface area was involved, and he was diagnosed with PPP after skin biopsy.


The authors describe a case of acute coronary vasospasm in a young patient undergoing thoracic laminectomy with biopsy of intramedullary tumor.


There is evidence that corneal calcifications are correlated with chronically administered phosphate-buffered eye drops (P<0.005).


Diagnosis and treatment of chronic postoperative bacterial endophthalmitis.


We review the 14 previous cases published in the literature and describe two additional patients.


Flavimonas oryzihabitans is a potential pathogen that may infect patients who have major medical illnesses, especially those who are undergoing surgery or have indwelling venous catheters in situ.


Although the cumulative probability of acute non-lymphocytic leukemia among surviving patients at five years using life-table statistics was 7.6%, the survival curve for the 553 patients with ovarian carcinoma was only slightly affected by death from leukemia.


A 57-year-old man developed chronic, watery diarrhea four weeks after Helicobacter pylori eradication therapy including lansoprazole followed by lansoprazole monotherapy for gastroesophageal reflux disease.


A patient receiving intradermal injections of vaccine directed towards carcinoembryonic antigen-bearing metastases from colorectal cancer showed uptake of 18F-fluorodeoxyglucose in local draining lymph nodes during the course of treatment.


Patients with endophthalmitis fared more poorly than those with blebitis in terms of visual outcome.


The IM route of administration was associated with higher mean daily doses (1.28 +/- 0.14 mg/day) than was oral administration (0.37 +/- 0.02 mg/day).


Albeit rare among Western patients, such lithium-associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese.


Phenylpropanolamine (PPA) recently has been publicly implicated as a cause of stroke and other neurologic events.


PURPOSE: The purpose of this report is to describe the management and outcome of an unusual complication of a commonly used chemotherapeutic agent.


However, with increased experience in applying BCG, the side effects now appear to be less prominent and few.


OBJECTIVE: To report a case of decreased international normalized ratio (INR) in a patient receiving warfarin and bosentan.


This case highlights the possible development of acute coronary syndrome as a side effect of Capecitabine therapy.


Gigantomastia induced by bucillamine.


Continuous irregular rhythmic generalized 2.0-2.5 Hz sharp-and-slow wave complexes intermixed with spikes and polyspikes more prominent over the frontocentral areas were seen on the EEG.


Although certain subgroups of patients have been shown to benefit from adjuvant therapy, continued efforts must be directed at identifying responders so that others will not be exposed to the additional risks of chemotherapy.


CONCLUSIONS: Our experience indicates that safely flying with newly diagnosed DM type 1 is possible.


The patient developed tonic-clonic seizures, which resolved with diazepam and midazolam therapy.


This paper reports an autopsy case of a 78-year-old male with multiple nodules in the liver developed after long-termed administration of phosphate diethylstilbestrol (PDES) for prostatic cancer.


We recommend the cautious use of ketorolac in patients with underlying illnesses where NSAID-induced ototoxicity could result in adverse otologic consequences.


Orthostatic hypotension was also noted at that visit, with a standing blood pressure measurement of 95/80 mm Hg.


We present three cases of women who developed acute transient myopia caused by drugs for gynecological problems.


Two days later, the patient's QTc interval had decreased to 546 msec, and she was discharged home.


Therapy with spironolactone and prednisone also normalized blood pressure.


Data on the use of 25-OH D show no greater benefit than for vitamin D.


The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.


Infliximab and nephrotic syndrome.


Only two of the six reported patients without heparinization survived.


Apparent central nervous system depression in infants after the use of topical brimonidine.


A search of MEDLINE (1966 to November 1998) and International Pharmaceutical Abstracts (1970 to November 1998) did not reveal a similar case.


However, these patients may be admitted to an intensive care unit (ICU) with complications of Wolff Parkinson White (WPW) syndrome; for example post cardiopulmonary arrest or WPW as a co-morbidity.


We have safely used recombinant factor VIIa to treat bleeding in the immediate and long-term period following PCC-related MI.


The potential role of propranolol in inducing central nervous system disturbances is emphasized, and the literature on the subject is reviewed.


Local administration of corticosteroids for rheumatic diseases have had a long history of effective and well-tolerated use.


We describe a 73-year-old woman who developed serious systemic vasculitis with associated thrombocytopenia in the course of treatment with cladribine.


In 6 patients with tumours secreting gastrin and/or glucagon, secretion of these peptides was acutely inhibited by SMS 201-995.


Kaposi's sarcoma, a neoplasm that occurs in immunocompromised patients and people of Mediterranean origin, usually presents with skin lesions.


Commonly reported adverse effects of the drug include nausea and vomiting, constipation, headache, and fatigue, as well as myelosuppression, which may be dose limiting.


Moreover, these findings suggest that the incidence of BOOP following rituximab therapy may be higher than has been previously appreciated.


Common peroneal nerve palsy following TNF-based isolated limb perfusion for irresectable extremity desmoid tumor.


The latter revealed sensitization to PTU during the acute phase of the disease, which was greatly reduced 5 weeks after discontinuation of the drug and was completely absent after 5 months.


Persistent hypoglycemia in a patient with diabetes taking etanercept for the treatment of psoriasis.


Although case reports exist concerning the positive impact of lamotrigine addition on clozapine treatment in resistant schizophrenia, a review of the literature fails to document any evidence regarding a combination of the two in the treatment of patients with schizophrenia and comorbid alcohol dependence.


With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.


Successful treatment of stutter priapism with an antiandrogen.


In unusual conditions surgical removal of thrombi in dilated cardiomyopathy may be a safer alternative.


With protein loss in the dialysate and a decreased serum albumin level, the patient developed ankle edema.


Median haemoglobin nadir for patients with ALL and AML was 4.5 g/dL (range 1.3-6.9) and 5.1 g/dL (range 2.6-6.8), respectively.


Most studies report incidence rates ranging from 1.5 to 3%.


A case of hepatocellular carcinoma in a young female is presented in which the apparent etiology was the use of oral contraceptives for 5 1/2 years.


The incidence of angioedema secondary to losartan, an angiotensin II receptor antagonist, is unknown.


He was treated with prednisolone, cyclophosphamide, cytosine-arabinoside and chlorambucil for the following three and a half years.


Seven patients with hematologic malignancies who were treated with miconazole for either suspected or proven fungal infections developed eight episodes of major adverse cardiorespiratory and anaphylactic reactions.


We describe a case of soft tissue infection caused by Fusarium species in a heart-liver transplant recipient, and review the cases of fusarial infection reported among solid-organ transplant (SOT) recipients.


It is a cumulative dose-dependent phenomenon reported to occur most often after 2 weeks of therapy.


We therefore concluded that acute pancreatitis is a rare manifestation of systemic lupus erythematosus, and corticosteroids do not appear to be the etiological agent.


The authors review the literature on this aspect and highlight the dangers of starting lithium treatment in patients with neurologic impairment.


CONCLUSIONS: Postural epigastric pain as a sign of CMV gastritis is fairly rare in renal transplant recipients.


Vasopressin (0.04 units/min) was administered through a peripheral venous catheter for hypotension unresponsive to exogenous catecholamines.


Recently clinicians have begun to employ it in several oft label usages in children, especially behavioral syndromes.


A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.


Replicate brain magnetic resonance imaging examinations after six weeks and 11 months of penicillamine therapy documented the development of new brain lesions during this period, while liver biopsy specimen data disclosed that excellent hepatic decoppering had occurred.


Pulse therapy may be equally as effective and may lessen the frequency of serious side effects.


We report two cases of fulminant hepatic failure in HIV-1-infected patients treated with didanosine (ddI).


A complication of the implantable constant infusion chemotherapy pump.


With the increasing use of tacrolimus in steroid-resistant nephrotic syndrome, the treating physicians need to be aware of this rare, but potentially life-threatening side effect.


A focal outbreak in a hospital.


Larvae can penetrate the skin, are carried hematogenously to the lungs, migrate up the bronchial tree, and then can be passed to the upper small intestine.


Even though steroids are well known to be effective on managing AIA and its nasal polyps, histochemical examinations after steroid therapy and at recurrence, involving eosinophil infiltration of nasal polyps, have been less studied.


Rasburicase for the management of tumor lysis syndrome in neonates.


Coexistence of bulimia nervosa and mania: a literature review and case report.


Simultaneously with the clomipramine dosage increase, clozapine was tapered and stopped ever a period of 19 days.


Diagnosis: practolol induced sclerosing peritonitis.


The epigastric pain completely resolved after treatment with ganciclovir.


A case report.


Carbamazepine-induced systemic lupus erythematosus-like disease.


Acute leukemia following combination chemotherapy for cancer of the lung.


The maculopapular rash progressed to formation of confluent nodules, plaques and finally erythroderma with lymphadenopathy and hepatosplenomegaly.


Ovarian hyperstimulation syndrome (OHS) is one of the potential complications associated with the use of human menopausal gonadotropin therapy.


Prolonged responses were achieved with low doses of HU (3-10 mg/kg/day) and higher doses were associated with mild reversible hematologic or hepatic toxicity and no further increases in Hb.


Toxic epidermal necrolysis (TEN) is a life-threatening bullous dermatosis characterized by the sudden onset of full-thickness epidermal necrosis.


The most progressive neurological deficits like severe tetraspastic paresis, were seen only in the nondialytic renal insufficient group (3 patients), while the others had a more benign course of the disease.


Taxanes are widely used chemotherapeutic agents with the potential to induce pulmonary injury through a variety of mechanisms.


After discontinuation of the 5-fluorocytosine and amphotericin B and treatment with cephradine and ketoconazole, the toxic epidermal necrolysis resolved.


The anemia continued because of bloody stool caused by Crohn's disease.


Minocycline-induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis.


Common adverse events (frequency 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence).


Fatal stroke in migraine: a case report with autopsy findings.


Gold nephropathy: tissue analysis by X-ray fluorescent spectroscopy.


It can cause severe CNS depression, especially in very young children.


High plasma levels of N-desmethyl-clobazam (N-CLB), the major metabolite of CLB were detected.


On the basis of the encouraging results of the initial series, this technique should be considered as an interesting therapeutic alternative in sciatica.


We describe a case of ulcerative proctitis after ibuprofen treatment in a girl with juvenile systemic lupus erythematosus.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


Their decreases in VAS scores were 86.5%, 85.7%, and 77.6%.


Treatment with oral contraceptive (OC) for endometriosis and later with cyclophosphamide, methotrexate, fluorouracil (CMF) for breast cancer produced a higher number of attacks.


This case emphasizes the importance of the evaluation of lithium-associated polyuria with a direct measurement of plasma vasopressin, interpreted with simultaneous plasma and urine osmolality to secure the correct diagnosis and ensure appropriate therapeutic management.


From 2947 admissions with systemic lupus erythematosus 25 (0.85%) were diagnosed as having acute pancreatitis; 76% of cases had active systemic lupus erythematosus on presentation, with an average of 4.4 organ involvement, and a clustering of renal disease (56%), pleural effusion (48%) and arthritis (44%) in these patients.


There is a paucity of literature etiologically inculpating other ephedra alkaloids in the causation of intracerebral hemorrhage.


DESIGN: Description of the clinical findings in two patients with this condition.


In a patient with severe renovascular hypertension, nonoliguric acute renal failure developed after she received captopril treatment.


Mannitol-induced ARF responds promptly to hemodialysis with rapid resolution of anuria and recovery of renal failure.


Local findings included swelling (94%), fang marks (93%), ecchymosis (53%), erythema (37%), bullae (13%), and tissue necrosis (8%).


She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.


Surgical re-siting of the intrathecal catheter produced good pain relief for many months.


Ciprofloxacin-induced psychosis.


PURPOSE: To report a case of Acanthamoeba infection following LASIK.


CONCLUSIONS: Patients with PDPH have classic postural headache.


RESULTS: The inflammatory mass was excised successfully, and several specimens were examined for bacteriologic presence.


Temozolomide was restarted 2 months later; the patient again developed a fever.


A patient with low-grade patch stage MF progressively developed MF plaques restricted to his arms, and a tumour on his right thigh.


Conspicuous endoscopic appearance of ventriculitis caused by coagulase-negative staphylococci.


The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.


Etoposide-related myocardial infarction.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


With continued clearing of consciousness, the patient was successfully discharged.


Recently, nonsteroidal anti-inflammatory drugs have been used to halt the growth of these tumors, presumably by interfering with prostaglandin metabolism.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


Many aspects of this syndrome suggest close similarities between DIHS/DRESS and graft-versus-host disease.


Diagnostic procedures aimed to explain lower leg edema are not uncommon in the age group of women suffering from climacteric and menopausal symptoms.


Although the drug is relatively safe, a growing body of literature has noted movement disorders after its administration.


The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.


Controversy as to what constitutes a safe and effective dose of these medications still exists.


Recombinant human erythropoietin in patients with myelodysplastic syndrome and myelofibrosis.


Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma.


After substitution of a standard diet starting August 21, we found significant decreases of total cholesterol from 725 mg/dl to 194 mg/dl and triglyceride from 4680 mg/dl to 550 mg/dl within 37 days.


CONCLUSION: The delayed treatment of lead poisoning may lead to irreversible motor neuron defect.


The electrocardiogram showed alternation of long and short P-P intervals and occasional pauses.


During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.


Given the evolving role of second autologous transplantations in the therapeutic armamentarium for multiple myeloma, consideration of this potential toxicity may be appropriate when considering treatment options for these patients.


Patients receiving neutral protamine Hagedorn (NPH) insulin are at increased risk for the development of protamine hypersensitivity.


Long-term clinical experience with many of these agents has revealed nonglycemic effects on lipid levels, inflammation, and cardiovascular function.


Bronchospasm is an anesthetic emergency that can lead to disastrous outcomes if treatment is irresolvable.


OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) inhibitors have emerged as a potent treatment for rheumatoid arthritis (RA), but not without significant risks.


Blood cultures were positive for Agrobacterium yellow group.


To our knowledge, the syndrome of fever, pulmonary infiltrates, and pleural effusion following use of acyclovir has not been previously reported.


Specifically, the complication of enzyme-induced hyperglycemia may be seen more frequently after exposure to the E. coli product.


We describe a drug-drug interaction between itraconazole and efavirenz in a patient with disseminated histoplasmosis and acquired immunodeficiency syndrome (AIDS).


Objective responses were observed in both basal cell carcinoma (BCC) patients.


Danaparoid was withheld during this time.


Cutaneous mycobacterial infection post intravesical BCG installation.


A 28-year-old man underwent pterygium excision with a single intraoperative application of mitomycin C (0.02%) for 3 minutes.


We report a 66 year-old man with well-documented, idiopathic generalized epilepsy who developed petit mal status lasting 6 weeks.


We conclude that the presence of this metabolic defect combined with topical 5-FU (a drug demonstrating a narrow therapeutic index) results in the unusual presentation of life-threatening toxicity after treatment with a topical drug.


The pulmonary emboli were thought to be associated with her oral contraceptive, which was discontinued at hospital admission.


It mandates emergency open heart surgery if hemostasis is not achieved promptly.


Ophthalmologists should undertake the above treatment in consultation with a pediatric endocrinologist.


Suicidal digoxin poisoning: conventional treatment and antibody therapy.


Three patients received prophylaxis with MB at a dose of 4 x 50 mg day(-1) i.v. for the subsequent chemotherapy cycles.


This case report stresses the need for control of the rheumatic condition prior to the initiation of antineoplastic therapy.


Metronidazole neuropathy.


We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.


The reactive process included an infiltrative superficial dermatitis and a mural folliculitis with prevalent participation of macrophages and lymphocytes.


Five patients are described in whom only gentamicin sulfate appeared responsible for acute renal failure.


Clinical spectrum, ancient mutations, and a survey of 100 American referrals to the National Institutes of Health.


These patients developed a debilitating photosensitivity that persisted for months to years even after they stopped taking the diuretic.


Because most infections are late complications and have indolent onsets, a high level of clinical suspicion is required for early diagnosis.


Controversy concerning the nephrotoxicity of lithium is discussed, and recommendations for the evaluation of renal failure during lithium therapy are provided.


The patient's initial serum calcium concentration was 5.25 mmol/L (21 mg/dL).


We report the case of a 17 years old female with a Ewing's sarcoma of the left femur treated with limb sparing surgery followed by local radiotherapy of 45 Gy and adjuvant chemotherapy with vincristine, doxorubicine, cyclophosphamide, actinomycin D.


However, increased dyspnoea and bronchospasm necessitated reintubation.


Two additional patients with midly abnormal responses to glucose tolerance tests showed no evidence of altered glucose metabolism when treated with halcinonide cream in a similar manner.


In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.


CONCLUSIONS: Physicians should be aware that drug-induced AIN can be associated with proton-pump inhibitors.


Beneficial effects of telmisartan in an HIV+ diabetic insulin-dependent patient.


This patient had previously been sensitized to protamine during cardiac catheterization and had high levels of protamine-specific immunoglobulin E in the serum.


Although inhibition of the angiotensin-converting enzyme is considered to be efficient treatment for hypertension associated with chronic renal failure, care should be taken when captopril is administered initially to a patient with decreased renal function, under the conditions of sodium and water depletion.


The use of electroconvulsive therapy (ECT) in MG raises certain challenges.


Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported.


This is the first report of pulmonary hypertension in an adult patient during lithium therapy.


A prospective study is currently underway to determine if a clinically measurable adverse effect on retinal function is seen with greater frequency.


These symptoms were unresponsive to conventional analgesic and antibiotic treatments.


Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.


A 32-year-old woman experienced ischemic stroke attributed to concomitant administration of a cough and cold preparation containing methylephedrine and a supplement containing Chinese herbal drugs.


We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.


We recommend following daily cell counts and vancomycin peak and trough levels to calculate the amount and frequency of intraventricular vancomycin required to maintain safe and effective concentrations and to monitor for CSFE.


A previously asymptomatic 62-year-old man with a history of hypertension and stable coronary artery disease developed paresthesias and fascicular and ventricular tachycardia after ingestion of an Ayurveda bowel regimen containing substrates from the Aconitum species, which is a known neurotoxin and cardiotoxin.


The ECG remained normal.


Albuterol-induced hypokalemia and its potential cardiac toxicity are discussed briefly.


All three patients had microcytic microchromic anemia with basophilic stippling of the erythrocytes, lead lines in X-ray of the knee joint and high blood lead levels.


RESULTS: LTG was withheld, and the patient experienced a complete recovery in conjunction with reduced serum levels.


The use of protease Inhibitors (PI) has been associated with many adverse effects including increased tendency to bleed, which is particularly problematic in individuals with congenital coagulation disorders.


Lichen planus induced by hepatitis B vaccination: a new case and review of the literature.


Within 24 h after the first injection to her left arm, the patient developed pruritus and erythematous papules at the injection site and painful papules on her hands.


Abemayor).


Use of alpha-agonists for management of anaphylaxis occurring under anaesthesia: case studies and review.


This article describes the interval appearance of malignant, linear-branching, microcalcifications during neoadjuvant chemotherapy for locally advanced breast cancer.


We report a case of a women in whom a malignant mixed mesodermal tumor was diagnosed while she was taking raloxifene, which is also a selective estrogen receptor modulator.


OBJECTIVE: To describe a patient with asymptomatic bronchial asthma and hypertension who developed an acute asthma attack after receiving sustained-release verapamil.


Gallstones and bile sludge are common side effects of octreotide therapy but rarely become symptomatic or require treatment.


PARTICIPANTS: Five eyes in four patients who underwent LASIK in different locations around the world and had culture-positive mycobacterium keratitis develop.


After discontinuing captopril and starting systemic steroids, her symptomatology rapidly improved, and her eosinophilia and radiographic abnormalities both resolved.


Oral antiviral and topical steroids in tapered dosages were administered.


Particular attention should be paid to tiny skull lesions and to key events preceding the pain.


Electrodiagnostic studies at variable points during the disease course showed signs of acquired demyelination consistent with CIDP.


Our case re-emphasizes the need for investigation of factors precipitating ARF in children with idiopathic NS.


Eight days after the end of interferon treatment, he showed signs of inability to sit still for ten seconds and walked around constantly.


A possible role for a factor with thrombosis-inducing activity (TIA).


A 43-year-old woman with multiple sclerosis (MS) had nephrotic syndrome 21 months after starting treatment with interferon (IFN)-beta-1b (subcutaneous administration).


We report one case of pregnancy-onset severe diffuse proliferative nephritis in a patient with systemic lupus erythematosus (SLE), who was successfully treated with a combination of anti-tumour necrosis factor (TNF)-alpha, plasmapheresis and high-dose intravenous gammaglobulin.


The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.


The intense stimulation of B lymphocytes and decreased T lymphocyte activity in asbestos-exposed populations may result in development of B-cell malignancies.


Three additional cases have also been observed.


Subclinical entrapment may thus be an important factor leading to vulnerability of nerves in lead neuropathy.


Reduction in the dose of olanzapine was followed by normalization of the white blood count which allowed continuation of the medication.


Cidofovir is an antiviral agent that has been proposed for treatment of BKVN.


Markedly increased pigmementation of skin immediately overlying veins used for multiple 5-fluorouracil infusions was noted.


Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.


The safety of cyclo-oxygenase 2 (COX-2) preferential inhibitors such as meloxicam is debated.


Effective treatment is available provided surgical manipulations cease.


RESULTS: Therapy consisted of 4 cycles of paclitaxel chemotherapy.


We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.


Treatment of non-Hodgkin's lymphoma with the CHOP regimen consists of intravenous cyclophosphamide 750 mg/m2 (day 1), intravenous doxorubicin 50 mg/m2 (day 1), intravenous vincristine 1.4 mg/m2 (day 1), and oral prednisone 100 mg (days 1-5).


The patient died approximately 6 months later of persistent and progressive retinoblastoma without any clinical evidence of lymphoma.


This is the first reported case of BOOP associated with single-agent rituximab, and along with two other patients we describe, as well as two prior reports of BOOP in NHL patients receiving rituximab-based combinations, strengthens the possibility of a causal relationship.


The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).


A 55-year-old woman presented an episode of acute urticaria and labial angioedema 60 minutes after ingesting 500 mg of cloxacillin for a skin abscess.


We describe a case of spontaneous muscle necrosis of the anterior tibial compartment occurring in a patient who had a hypophysectomy for a craniopharyngioma five years previously.


Uncommonly, erythema multiforme (EM) can develop in such patients at the port site during or soon after cranial radiation and can rapidly progress to EM major.


One patient also developed bilateral angle closure glaucoma.


He stopped this therapy in February 1996 because of asthenia, diplopia, headache, and anxiety.


All patients experienced severe anaemia after induction chemotherapy despite erythropoietin.


Differential diagnosis is very important and anti-tuberculous drugs must be continued if the diagnosis is tuberculosis.


It is our experience that a good outcome is dependent on early and specific treatment.


We report the case of a 23-year-old woman with diffuse large-cell lymphoma who received an accidental overdose of this chemotherapeutic regimen.


These findings, together with increased urinary copper excretion and the absence of clinical improvement, are compatible with a generalized defect in copper metabolism, transport or storage.


Autopsy findings were consistent with bleomycin and oxygen-induced pulmonary damage.


RESULTS: There was an immediate clinical improvement (increased alertness, improved concentration) but severe hypernatraemia developed (peak 169 mmol/l) necessitating revision of his desmopressin and fluid intake regimen.


The complete treatment schedule required the administration of a total of 708 mg of recombinant FVIIa.


We report a case of baclofen withdrawal syndrome resulting from oral baclofen underdosing.


In this respect, we present two patients with hypertension and dyslipidaemia together with elevated serum uric acid levels.


Eyes from two individuals examined at autopsy showed significant changes.


Metabolic balance studies and rechallenge with hydrochlorothiazide were undertaken to investigate the mechanism of the thiazide-induced hyponatremia.


Renal failure associated with the use of dextran-40.


We should also bear in mind that BMD scores alone are not indicative of fracture risk, and other tools such as the WHO-FRAX (Fracture risk assessment tool), serum vitamin D3 levels and bone turnover markers should be used where appropriate.


Histological examination revealed hyphae and arthrospores in the hair follicles and in the dermis with a diffuse dermal infiltrate consisting of lymphoplasmacytic cells, and focal collections of epithelioid cells, neutrophils and mild interstitial edema.


Common causes of residual limb pain and the pharmacology of capsaicin cream are discussed.


CONCLUSIONS: We report this case of the concomitant appearance of multiple skin cancers and nail changes associated with hydroxyurea use.


Reversible sirolimus-associated pneumonitis after heart transplantation.


We report a patient who developed spontaneous splenic infarction after the use of sumatriptan for the treatment of migraine headache.


While undergoing treatment with albendazole, he developed worsening diarrhea with abdominal pain and fever.


CASE SUMMARY: An 89-year-old man was admitted for dementia with behavioral disturbance and psychosis and was started on olanzapine 2.5 mg twice daily.


The mean CYP2D6 activity is lower in Oriental than in Caucasian populations, because of a frequent mutation causing decreased enzyme activity.


The ninth patient stopped taking the preparation immediately because of swollen nasal mucosae.


We describe an infant with minimal exposure to oxygen who developed AP-ROP that led to bilateral retinal detachments and a poor visual outcome, despite following current recommended screening guidelines.


We report a 30-year-old African-American woman with a contiguous diagnosis of breast cancer and paraneoplastic SSc.


The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia.


RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings.


BACKGROUND: Antidepressants can sometimes cause agitation, particularly in patients with bipolar disorder, but concern about such effects is generally limited to the first weeks and months of treatment.


We report its successful use in the treatment of a nodular basal cell carcinoma.


Adverse reactions to reserpine were reported in 26 patients (11.3 per cent), but only three of these reactions were considered life-threatening and no deaths were attributed to the drug.


Systemic allergic contact dermatitis to 8-methoxypsoralen (8-MOP).


The remaining clinical scenarios included intravenous catheter sepsis and factitious disorders.


Superior sagittal sinus thrombosis was demonstrated by cerebral angiogram.


The use of fresh frozen plasma and/or danazol before treatment prevents angioedema attacks.


The aim of this study was to describe the occurrence of acute coronary syndromes in 3 cases of rituximab infusions.


However, because ADPKD is a bilateral disorder, ACE-inhibitor therapy may worsen renal function, as occurs in patients with bilateral renal artery stenosis.


The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.


RESULTS: All three patients developed a biochemical-histologic pattern of cholestatic liver injury with damage to the interlobular bile ducts.


Pulmonary thromboembolism was diagnosed, based on: (1) blood gas analysis findings of hypoxemia and (2) defective images in both of the upper lobes on urgent pulmonary blood flow scintigram.


Thus, tacrolimus-induced HUS is a rare cause of ARF in nephrotic syndrome.


Foreign body granuloma of activated charcoal.


MAC infection persisted despite treatment, however, no anti-MAC drug-resistant isolates emerged throughout the clinical course in either case.


We conclude that myocardial infarction may develop in patients treated with high-dose glucocorticoids for Graves' ophthalmopathy, and increased blood pressure may herald this complication.


At our institution, high-dose i.v. dexmedetomidine is used to provide sedation for pediatric patients undergoing nonpainful radiological imaging studies.


The presented patient was treated with 200 mg TCA and developed Cushing's syndrome 6 weeks later (cortisol and ACTH concentrations were below limits of detection, TCA concentrations were > 3 micrograms/l).


Mild photophobia was the most common side effect, but could be easily overcome by wearing sunglasses.


A 48-year-old woman who was treated for thyrotoxicosis with methimazole developed agranulocytosis.


We report an allogeneic bone marrow transplant recipient who developed CMV infection refractory to sequential therapy with ganciclovir, foscarnet, and cidofovir.


This analytic procedure allows an exact calculation of the statistical variance at the final decision node using automated symbolic manipulation.


We present the case of a 20-year-old patient with Hodgkin's disease developing BOOP after chemotherapy (COPP/ABVD) and irradiation.


Chronic nausea and morphine-6-glucuronide.


Ultimately, this may possibly predispose a patient to increased dermatologic reactions, including TEN.


PURPOSE: To describe the use of intravitreal bevacizumab followed by sectorial retinal photocoagulation to treat the neovascular complications of laser-induced chorioretinal anastomosis (L-CRA) for nonischaemic central retinal vein occlusion (CRVO).


These patients appear to have experienced "spontaneous" hypertensive episodes temporally related to the ingestion of the MAOIs.


Assuming that maintenance therapy is necessary for optimal efficacy, the issue of BCG toxicity becomes more relevant.


Spontaneous nasal septal perforation with antiangiogenic bevacizumab therapy.


We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.


Torsade de pointes during loading with amiodarone.


The authors report on the effects of acute confusional states and deliria (pharmacogenic confusional syndromes - PCS), occurring under the influence of psychotropic drugs on the depressive syndrome of three patients.


Emergence of cotrimoxazole- and quinolone-resistant Campylobacter infections in bone marrow transplant recipients.


Its clinical manifestations include severe periarticular pain with inflammatory signs, especially in knees and ankles, causing functional disability.


Another enzyme catalyzing the metabolism of antidepressants is the polymorphic S-mephenytoin hydroxylase.


We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).


He had experienced only 2 mild peritonitis attacks with fever within 1 year.


Treatment with local antibiotics was initiated but the condition of the eye worsened, ultimately resulting in corneal perforation.


One patient was treated with disothiazide for premenstrual edema.


Deepening of lid sulcus from topical bimatoprost therapy.


Serologic responses were highly suggestive of T. gondii as the etiology in all cases; other causes (CMV retinitis and syphilis) were actively sought and were not found.


The beta-oxidation pathway of VPA was shown to be suppressed (lack of 3-keto-VPA), whereas metabolites from the omega-oxidation pathway could still be measured (urinary 5-OH-VPA plus 2-propylglutaric acid ca. 1.6%, controls more than 10%).


One previous study of four transplant patients whose immediate post-transplantation immunosuppression utilized corticosteroids, cyclosporine, MMF, and anti-T-lymphocyte globulin noted anemia in 13% of them.


Fine-needle aspiration cytology in locally advanced breast adenocarcinoma: a case with complete response to preoperative chemotherapy in association with granulomatous inflammatory reaction.


A specific autoimmune disease was not identified.


In court, the female offender confessed and was sentenced to prison for 3 1/2 years.


This case demonstrates an occupational activity (construction) that has now become the dominant source of lead exposure for U.S. adults, the importance of a good occupational history to suspecting and making a diagnosis, the possible outcomes of chronic lead toxicity, and the importance of preventing further exposure and using proper methods to treat acute toxicity.


A 34-year-old man presented 4 months after renal transplantation with a 1-week history of epigastric pain that decreased in supine position, increased while sitting, and further increased when standing or walking.


A 65-year-old man with advanced prostate cancer was treated with a luteinizing hormone-releasing hormone (LH-RH) analogue.


Squamous cell carcinoma in vitiligo lesion after long-term PUVA therapy.


On the second day of hospitalization, it was noted that the patient's dyspnea and sinus bradycardia could be related to a recent increase in his timolol dosage.


This study presents the case of rapidly progressing pulmonary aspergillosis in a 47-year-old woman who had healed cavitations of pulmonary tuberculosis in the right upper lobe.


The drug, widely used in gastroenterological and gynaecological practice, has not hitherto been considered neurotoxic.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


Postoperative imaging did not disclose any intra-orbital abnormalities.


CASE SUMMARY: A 45-year-old HIV-positive man (CD4+ count 450 cells/mm(3) and history of AIDS-defining illness) presented with JHR after an initial intravenous dose of penicillin G for presumed neurosyphilis.


OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection.


It has been recently approved for the treatment of multiple myeloma, an incurable plasma cell tumour that accounts for 10-15% of all haematologic malignancies and for approximately 20% of deaths.


We report the successful treatment of heparin-induced thrombocytopenia and subsequent hemorrhagic complications postoperatively in a 2-year-old child with Danaparoid (orgaran).


A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.


Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon.


Neuroleptic malignant syndrome (NMS) is a potentially life-threatening adverse effect of antipsychotic agents.


A study protocol to manage these patients within a multidisciplinary team including also specialists in infectious diseases and virologists is mandatory.


She had no other causes of immunosuppression.


By X-ray fluorescent spectroscopic examination, gold was seen to be present within the proximal convoluted tubular cells but was not identified in the glomerular subepithelial deposits.


All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis.


Methylphenidate and dextroamphetamine-induced peripheral vasculopathy.


Prolonged exposure to ART, specially ddl, can play a pathogenic role.


Pulmonary infiltrates and skin pigmentation associated with sulfasalazine.


Nitrofurantoin therapy was discontinued.


We hypothesize that capecitabine-induced headache is vascular in nature.


Desmopressin is a commonly used, well-tolerated agent for the treatment of primary nocturnal enuresis and central diabetes insipidus.


The combination of sulfadiazine and pyrimethamine is regarded as the treatment of choice.


The progress and management of this complication are described in the patient is being reported.


Lamivudine is the most widely prescribed drug of choice for chronic hepatitis B infection, which is a common health problem in China.


RESULTS: The population consisted of 11 female and 2 male patients with RA.


Further studies are needed to confirm this association and to determine whether inhaled adrenergic agents also contribute to the development of this disorder.


The psychotic behavior resolved completely soon after the discontinuation of levetiracetam.


The episode appeared to have been precipitated by toxicity due to ingestion of a large amount of phenytoin.


Severe acidosis from acetazolamide in a diabetic patient.


Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range.


Laser in situ keratomileusis (LASIK) carries the risk of infection.


All parameters returned to normal after the herbal preparation was discontinued.


Cyproterone acetate (CPA) is a steroidal synthetic progestagen and anti-androgenic compound widely administered in prostate cancer which has been evidentially correlated with a severe hepatotoxic potency.


We report the case of a 14-year-old female with acute promyelocytic leukemia who developed symptomatic cardiomyopathy only 4 months into treatment with a combination of daunomycin and all-trans retinoic acid (ATRA).


Our findings suggest that hyperkalemia can develop with the use of low-dose heparin, within seven days of initiating heparin therapy, and that patients with diabetes mellitus or chronic renal insufficiency are especially predisposed to this complication.


Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.


These results suggested that the visual dysfunction might be entirely attributable to retinal rather than optic nerve toxicity.


There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.


They provided conflicting testimony as to alleged violations of the standard of care.


OBJECTIVE: The aim of this study was to introduce a useful diagnostic method to evaluate baclofen pump system-related complications without disturbing the continuous delivery of intrathecal baclofen.


A 4-year-old boy presented with fever, septic arthritis, and persistent neutropenia.


The most likely cause of liver failure in this patient was, therefore, clarithromycin, which undergoes hepatic metabolism and has been reported to cause fulminant hepatic failure.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


The granulomatous hepatitis occurred in the apparent absence of mycobacteria from the liver.


Methadone withdrawal when starting an antiretroviral regimen including nevirapine.


Cisapride enhances detrusor contractility and improves micturition in a woman with lazy bladder.


A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.


Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.


The patients typically exhibit a brief preleukemic phase and poor survival with death occurring 3 to 5 months after diagnosis of leukemia.


RESULTS: Amino acid PET, performed when the lesions were still small, showed multiple small areas of mild uptake in close correlation to the MRI lesions.


So this potential drug-drug interaction could be investigated, the patient stopped taking both drugs for 1 week.


Pharmacokinetic modeling suggested that the patient's initial over-treatment was as reported and that the predicted maximum serum concentration of chloroquine (902 micro g/L) was within the range seen in fatal chloroquine overdose.


In the present paper, we discuss the first Japanese vivax malaria patient whose QT interval was prolonged after treatment with halofantrine.


Additive pulmonary toxicity with melphalan and busulfan therapy.


Nevertheless, osteonecrosis of the jaw (ONJ) has been reported in some patients being treated with bisphosphonates.


GH insufficiency has not been recognised as a classical manifestation of this syndrome.


Wolff Parkinson White (WPW) syndrome: what the critical care nurse needs to consider when administering antiarrhythmics.


PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.


Clinical aspects and electrophysiological data such as polygraphic studies, electroencephalography, and measurement of somatosensory evoked potentials support the cortical origin of negative myoclonus.


We report 3 cases of children with acute lymphoblastic leukemia who developed seizures and altered sensorium after L-asparaginase therapy.


Rituximab-CHOP induced interstitial pneumonitis in patients with disseminated extranodal marginal zone B cell lymphoma.


A case of pyridoxine-dependent seizures is reported.


Close monitoring for QT prolongation or rhythm disturbances is mandatory.


Symptoms develop during the first 3 months after transplantation and usually disappear 3 to 6 months later without sequelae.


Conversely, similarities between patient reports and reports from healthcare professionals were found in age, sex, most frequently reported ADRs and most frequently reported drugs.


CASE: A 48-year-old male patient with a history of tuberculosis and visual loss during anti-tuberculous drug therapy was admitted to our hospital.


The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.


Gestational diabetes was no less severe (degree of hyperglycaemia, need for insulin therapy) when associated with norethisterone.


Little is known about the prevalence of genotypes and implications for screening in children.


On subsequent follow-up one patient is taking no insulin and has been maintained on hydrochlorothiazide; the other patient required insulin on two occasions when challenged with a propranolol-thiazide combination, but not when the thiazide was discontinued or replaced with furosemide.


The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy.


A kidney biopsy revealed that he had focal segmental glomerulosclerosis.


All the patients presented with severe retrosternal pain worsened by swallowing food and drink, and in every case fibre-optic endoscopy revealed ulceration of the midoesophagus.


We studied a series of patients to determine the onset, visual significance, treatment, and recurrent nature of these pigmented membranes in patients who underwent surgery with silicone lens implantation.


Those reporting SCs significantly more often reported weight gain than those reporting TSCs, with oral problems and appetite loss significantly less common in the SC group.


We describe two cases of PSVT that changed to non-sustained polymorphic ventricular tachycardia after administration of verapamil.


The patient denied taking other drugs.


Telescoped digits of the hands and feet developed in a 69-year-old male with severe chronic tophaceous gout during allopurinol treatment.


In 2 cats, rebound hyperglycemia was diagnosed on routine serial blood glucose determinations.


We report a 5-year-old boy with CF who had a stricture of the hepatic flexure region with associated narrowing due to submucosal fibrosis of the transverse colon, secondary to high-lipase pancreatin therapy.


First, a review of the literature produced 41 anecdotic cases of neutropenia or agranulocytosis during treatment with olanzapine (Zyprexa) reported in a total of 24 publications.


Prompt recognition of this syndrome and temporary cessation of CyA therapy may favorable affect the course.


Cure followed therapy with antibiotic administration for 3 days combined with oral thiabendazole, suggesting parasitic infection as the most likely cause of meningitis.


Outside the initial associated URTI and LRTI, no further viral pneumonia occurred.


He experienced a severe skin reaction diagnosed as toxic epidermal necrolysis.


A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli.


Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.


Although they had only a few nodules at diagnosis, the nodules increased in number and size 3 to 4 months after the start of methotrexate therapy in both patients.


There was no previous history of seizure disorder and he was on no other medications.


Alopecia, nausea, and vomiting were attributed to the cyclophosphamide component of the therapy.


A potentially more common pharmacogenetic syndrome.


Likewise, Chinese herbal drugs are considered to be effective and to have few side effects.


All were females (age range: 43 to 73, mean = 61.7 years) and had taken quinine for leg cramps.


This case of linezolid-associated acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with linezolid raises concerns about the presumed renal safety of this drug.


The authors describe a clinical case of cutaneous candidiasis in a dog with dermatological lesions, characterized by persistent alopecia, crusts, ulcers and scales.


We describe a case of disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci) induced by praziquantel therapy, an event not described previously.


Transtentorial herniation caused by an intracranial mass lesion following high-dose methotrexate.


Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.


Apomorphine and diphasic dyskinesia.


We experienced two cases of CE in patients with severe atherosclerosis whose renal function deteriorated within a few months after invasive arterial maneuvers.


Other associated changes included koilonychia, dystrophy, and friability of nail plates.


Based on these findings, the patient was diagnosed with diabetes insipidus secondary to lithium therapy and was treated successfully with amiloride.


Loss of vision and renal function in a patient with miliary tuberculosis.


Early onset Pneumocystis carinii pneumonia after allogeneic peripheral blood stem cell transplantation.


We report the case of a 51-year-old man in whom IFN-alpha treatment was followed by recurrence of Graves' disease 10 years after thyroidectomy was performed and the patient was declared cured.


We recommended debridement as treatment; however, he refused further surgical intervention by reason of symptomatic remission.


(2) Rehabilitation of a 29-year-old man with a 7-year history of ankylosing spondylitis who lived in an adjustable easy chair for 2 years due to severe pain prior to admission.


Infliximab-induced lupus in Crohn's disease: a case report.


Classically used in combination with a multiagent-chemotherapy regimen, it can sometimes give excellent results alone.


There was neither intrathecal chemotherapy nor brain irradiation.


In view of the known leukemogenic effect of cytotoxic drugs, we presume that chemotherapy played a role in the pathogenesis of malignant myelosclerosis in these two patients.


Although this type of hyperpigmentation has been previously seen in patients with cancer who are receiving bleomycin, this is, to our knowledge, the first reported case of bleomycin-induced hyperpigmentation in an AIDS patient and should be added to the growing list of cutaneous eruptions seen in these patients.


Allopurinol-associated hand and foot deformities in chronic tophaceous gout.


After diagnosis by transesophageal echocardiography, the patient was treated with recombinant tissue plasminogen activator through a central venous catheter advanced into the right atrium.


Analysis of a urine sample was 2+ positive for hemoglobin.


Fixed drug eruption (FDE) is an unusual type of cutaneous adverse drug reaction that is characterized by recurrent site-specific lesions each time the drug responsible is taken.


Occasionally, traditional analgesic medication regimens cannot be used or are ineffective in relieving the pain.


Herpes simplex esophagitis is a rare disease occurring mostly in immunocompromised and cancer patients.


Pathological gambling associated with dopamine agonist use in restless legs syndrome.


We report a cytomegalovirus (CMV) IgG +ve 56-year-old patient who underwent autologous rescue with CD34(+) selected peripheral blood stem cells as part of consolidation therapy for multiple myeloma and subsequently developed CMV colitis.


This effect of cisapride is presumably related to its serotonin3 antagonistic property.


Serum levels of interferon-gamma, soluble interleukin-2 receptor, interleukin-6, tumor necrosis factor-alpha, and macrophage colony-stimulating factor (M-CSF) were elevated.


Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: four patient reports.


However, epidural infusion of local anaesthetic caused a delay in recognising a potential neurological complication.


This case demonstrates that patients with idiopathic ANCA-positive vasculitis may quickly develop a superimposed drug-associated ANCA-positive vasculitis.


Panuveitis associated with multiple sclerosis complicated by cerebral venous thrombosis.


Growth dynamics of meningiomas in patients with multiple sclerosis treated with interferon: report of two cases.


We report two male patients with Parkinson's disease who developed compulsive risk-seeking driving behaviour as a result of self-administering high doses of L-dopa despite an adequate therapeutic response at lower doses.


We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation.


A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.


It should be recognized that ibuprofen may be associated with salt and water retention in the same fashion as previously described with phenylbutazone and indomethacin.


We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.


Our findings suggest that chronic GVHD may be complicated with diffuse proliferative glomerulonephritis through unknown cellular immune mechanism.


Avascular necrosis of bone is a recognised complication of glucocorticoid treatment--the risk of this increasing with higher doses and longer duration of use.


The patient had no previous history of psychiatric problems.


So far nine patients on digoxin have received between 550 and 1000 mg/m2 of doxorubicin without ill effect.


The patient improved clinically, and 5 years later continues to do well.


It inhibits delayed rectifier potassium channels in the myocardium, causing delayed repolarization and QT-interval prolongation.


INTERPRETATION: When high doses of fluticasone propionate are used, growth may be retarded and adrenal suppression may occur.


Coronary angiogram showed a severe stenosis in the proximal segment of the LMCA; we performed stenting with a paclitaxel-eluting stent (PES).


Histological studies showed scattered perivascular infiltrates without vasculitis.


We report on a child with fatal valproate-related hepatotoxic effects despite this supplementation.


Intravenous phenobarbital was administered in escalating doses of 65 mg followed by 130 mg 15 minutes later, resulting in control of severe agitation in the face of benzodiazepine resistance.


Use of rituximab and irradiated donor-derived lymphocytes to control Epstein-Barr virus-associated lymphoproliferation in patients undergoing related haplo-identical stem cell transplantation.


However, he developed acute exacerbation of hepatitis due to HBV reactivation.


Report of three cases and review of literature.


A 57-year-old woman received 400 mL (62.4 mg) of a cisplatin solution concentrated to deliver cisplatin 100 mg/m2 during her first attempted therapy.


Capecitabine, a new member of the fluoropyrimidine family, is an orally administered drug that delivers fluorouracil (5-FU) selectively to the tumour.


L-Carnitine supplementation has been recommended to prevent the fatal hepatotoxic effects associated with valproic acid.


We describe 5 patients with severe pompholyx who did not respond to conventional therapy or who had debilitating side effects from corticosteroids.


One patient developed irreversible bilateral blindness and another unilateral blindness secondary to optic neuropathy.


RESULTS: An 81-year-old man with a history of neoplasies of the colon and prostate and anticoagulant treatment was referred for treatment of an ocular surface neoplasia on his left eye.


Positive cytology must be conclusive since, as in this case, no viable carcinoma may be present after therapy.


We describe a patient who developed NEH on three separate occasions provoked by two different chemotherapeutic agents--cytarabine and mitoxantrone.


The use of sunitinib in dialysis patients is poorly described but is of clinical importance.


We conclude that there is insufficient evidence either to establish or eliminate a direct causal relationship between ACC and MMI use.


A CT scan of the brain showed numerous small discrete lesions.


DISCUSSION: The severity and presentation of central nervous system toxicity due to ifosfamide varies greatly and involves a spectrum ranging from subclinical electroencephalogram changes to coma.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


We report a case of a patient with squamous cell carcinoma of the throat above the larynx (supraglottic), who did not adhere to dental treatment recommendations for both pre- and post radiation dental management.


When vague symptoms develop during desmopressin therapy, hyponatremia must be considered as part of the differential diagnosis.


CONCLUSION: Ushaar latex is capable of penetrating the corneal stroma and inducing permanent loss of endothelial cells.


It occurs in approximately 0.07-2.2% of patients treated with neuroleptics.


We describe two patients with rheumatoid arthritis who developed chronic inflammatory demyelinating polyneuropathy (CIDP) during their course of therapy with TNF-alpha antagonists.


Although after 4 weeks of treatment with corticosteroids the chest X-ray and lung function were still abnormal, bronchoalveolar lavage showed a normal cell distribution.


A painful gum.


Cardiac evaluation revealed acute congestive heart failure with a cardiac ejection fraction of 19%.


Carbamazepine-induced systemic lupus erythematosus.


After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin.


Two case reports.


Now, malaria should first be presumed if a patient complains of a higher fever after a visit to a tropical country.


The desaturation of mixed venous blood amplified the effect of these shunts in decreasing arterial oxygen saturation.


DISCUSSION: Reactions associated with arylamine sulfonamide-containing antibiotics have been commonly reported; however, cross-reactions with non-arylamine sulfonamide-containing medications have been rare.


ARDS has been associated with the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3 and is believed to be directly mediated by release of proinflammatory cytokines.


We report a case and discuss its presentation and management.


Repeat studies performed 7 months later indicated some improvements in this indirect assessment of endogenous TRH reserve capacity but a continued exaggerated TSH response to exogenous TRH administration.


Hematochezia subsided with conservative treatment after a discontinuance of Kalimate administration.


Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.


Following these basic sinus cycles, alternating rhythm started with the longer P-P interval.


Inadvertent discogram during epidural steroid injection: a case report.


The potential for absorption is not well described in patients with impaired gastrointestinal (GI) mucosa.


Only one death has been recorded in the responding group.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


Methotrexate serum concentrations must be monitored because of the possible toxicity of drug elimination delay.


Physicians should be aware that indinavir nephrolithiasis may cause papillary necrosis.


All three patients (and possibly a fourth) who developed AML were postmenopausal, received continuous chlorambucil for greater than or equal to 4 years, had acute red cell anemia at the time of treatment, and had a wbc count in the range of 2700-7700/mm3.


Whole blood histamine release studies were negative.


Two 65-year-old white men with coronary heart disease, given niacin therapy for dyslipidemia for 5 months, developed intense dental and gingival pain that was associated with increases in dose and that was relieved with discontinuance of niacin treatment.


RESULTS: Two patients were obese and developed extensive abdominal wall skin necrosis.


PLD also has a different cutaneous side effect profile than doxorubicin, and its cutaneous toxicity can be dose limiting.


The major problems affecting compliance with pharmacotherapy for schizophrenia are outlined here showing, by means of case histories, how sertindole has benefited schizophrenic patients.


Transient visual anomalies associated with drug treatment for spastic colon.


No oligodendroglias with intranuclear inclusions were found.


This article reviews current human and veterinary literature regarding the microbiology, pathogenesis, and treatment of nocardiosis and reports on the successful treatment of systemic nocardiosis in two dogs.


Withdrawal emergent syndrome (WES) is a subtype of tardive dyskinesia that has been reported in children who were taken off antipsychotic therapy.


We present the case of a 19-year-old male athlete with protein C deficiency who developed proximal deep venous thrombosis and pulmonary embolism while abusing anabolic-androgenic steroids.


In conclusion, intradermal skin tests can be a useful tool for detecting a potential cross-reaction between platinum salts.


Beriberi is the systemic counterpart of thiamine deficiency and often manifests in cardiovascular collapse.


HRCT obtained on inspiration showed dilated thick-walled bronchioli, and innumerable centrilobular linear and branching structures in the bilateral middle and lower lobes.


One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).


To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.


Average length of stay postCDT was 7 days with no perioperative complications.


Zolpidem (Ambien), a relatively new nonbenzodiazepine sedative-hypnotic, was involved in the death of a 39-year-old obese male who was being treated for depression and insomnia.