We note that ITB withdrawal is similar to serotonergic syndromes, such as in overdoses of selective serotonin reuptake inhibitors or the popular drug of abuse 3,4-methylenedioxymethamphetamine (Ecstasy).


An immediate cholestatic liver reaction was also provoked by drug rechallenge, with spontaneous amelioration of signs and symptoms after drug discontinuation.


Her postoperative course was further complicated by a fungal infection.


Although the literature on the use of risperidone in elderly patients with dementia consists largely of uncontrolled trials, case reports, and chart reviews, it appears that this agent is effective for managing agitation in this population and does so with a low frequency of extrapyramidal symptoms (EPS).


Subsequently, the pedicle screws were removed.


Other organisms, including unusual bacteria, fungi, and mycobacteria, comprise 5% or less of cases.


Inadvertent injection of corticosteroid into the choroidal vasculature.


Further study of this potential health risk in needed.


Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.


No other identifiable factor contributed to the unresponsiveness.


LTG toxicity should be considered in patients taking this drug who have depressed mental status.


DESIGN: Noncomparative, interventional case series.


Seven months after continuous antitubercular treatment, the KS nodules regressed spontaneously and finally disappeared.


A 60-year-old woman with diabetes mellitus (type 2) developed an acute icteric hepatitis-like illness 6 weeks after the initiation of gliclazide therapy.


CONCLUSION: Lipoid pneumonia as a result of mineral oil aspiration still occurs in the pediatric population.


MATERIALS AND METHODS: A phase II study.


Thyrotropin concentrations and cardiac systolic time indexes during the elevation of serum CK concentrations were not consistent with hypothyroidism.


Most of these patients presented with complex symptoms arising from a variety of pathological conditions including ischemic heart disease, myocardial infarction, cerebrovascular accident, pneumonia, and trauma.


RESULTS: Fifteen patients (10 male) were interviewed (median age 49.5 years, range 24 to 68 years).


The reported frequency in young children varies (1-4).


Cardiopulmonary bypass support can be considered as a salvage therapy.


In this study, we report on three individual patients who received BTX-B and who subsequently developed parasympathetic dysfunction of the visual system after injections of BTX-B at remote sites.


Laboratory studies yielded substantially increased serum procollagen III levels and anticardiolipin antibodies accompanied with anti-beta(2) glycoprotein I, findings not previously described with this disorder.


Peripheral blood count revealed pancytopenia and a bone marrow biopsy was consistent with aplasia.


Trough whole blood tacrolimus concentrations ranged from 1.7 to 6.2 microg/L.


While the pathogenetic and clinical relationship between the different autoimmune-dysreactive complications is still unclear, and the supporting role of the frequent immunosuppressive treatment may add significantly to these risk factors, clinicians who are engaged in the management of these patients should be aware that multiple, concurrent or subsequent disorders might occur in these subjects, and also that severe infections might be of relevant concern.


No gastrointestinal tract or muscular abnormalities were found, and the discomfort was attributed to neuropathic pain.


Because the cerebellar toxicity may be worsened by continuation of therapy after initial onset of symptoms, prompt termination of HDARAC is recommended.


Trimethoprim-sulfamethoxazole, pseudomembranous colitis, and spinal cord injury.


One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).


For neurologists faced with the task of treating PD patients, the available array of medications may be confusing and intimidating.


Serum complement components and immunoglobulin levels were within normal limits, and radioallergosorbent testing gave negative results.


Masculinization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment.


We suggest that objective evaluation of retinal function with electrophysiological methods should be performed in patients with visual disturbance during treatment with rifabutin.


Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.


Gentamicin alone may be nephrotoxic and should be given with particular caution to the elderly and those with even mild kidney abnormalities.


On day four he was noted to have complete right sided femoral and left sided lateral femoral cutaneous nerve of thigh neuropathies.


It is generally well tolerated and significant adverse reactions occur rarely.


Bronchiolitis obliterans organizing pneumonia (BOOP) is a rare disease, which is histopathologically defined by the presence of granulation tissue in the bronchioles, alveolar ducts and alveoli leading to plugging of the bronchiolar and alveolar lumen.


Gold-induced aplastic anemia.


We report 2 cases of maculopapular eruption and fever in patients infected with human immunodeficiency virus (HIV) on the 2nd day of first administration of ritonavir, a protease inhibitor.


Graft-vs-host disease (GVHD) is a potentially treatable cause of progressive neurologic decline after bone marrow transplantation (BMT).


The case of a premature intra-uterine growth retardation (IUGR) infant, born from caesarean section to a mother with hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome, and admitted to NICU for low birth weight is reported.


Three of the seven subjects showed marked improvement in behaviour, with NPI scores dropping significantly over time.


We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI).


The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.


At 13.25 years rhGH therapy was discontinued owing to frequent hypocalcemic crises; serum IGF-1 levels were persistently low in the following years (between 160 and 180 microg/l, normal range for age 250-600 microg/l).


Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.


Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.


Among CNS toxicities, generalized tonic-clonic seizures have been reported in both children and adults.


We present a 49-year-old woman with refractory myofascial pain of many years duration who developed subacromial impingement syndrome (SIS) following a series of botulinum toxin injections to the bilateral upper trapezii.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


CONCLUSIONS: Intravitreal bevacizumab appears to be an effective tool in the immediate control of neovascularization following L-CRA for nonischaemic CRVO.


Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.


Endoscopic application of photodynamic therapy for cholangiocarcinoma.


Clinical and biochemical abnormalities disappeared soon after discontinuation of PTU.


Alternaria is a very common and saprophytic fungus.


Multicenter randomized study of two once daily regimens in the initial management of community-acquired respiratory tract infections in 163 children: azithromycin versus ceftibuten.


Only a prospective two-arm ALL dexamethasone study at two dose levels (6 and 10 mg/m(2)/day) will clarify if indeed the higher dose of dexamethasone during induction is more effective and without unacceptable toxicity.


The serum levels of calcium hopantenate were high in coma, and that of pantothenic acid examined in one patient was lowered.


OBJECTIVE: Transcatheter arterial embolization (TAE) with gelatin sponge particles and iodized oil often yields poor results when used to treat unresectable multifocal hepatocellular carcinoma (HCC).


Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.


Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.


This patient was previously well with no known cardiovascular risk factors.


Pulmonary hypertension during lithium therapy: clinical case study.


Pulmonary toxicity is believed to be uncommon.


Argatroban is hepatically cleared and may be the preferred direct thrombin inhibitor in the presence of significant renal impairment, but conversely has prolonged effects in hepatic failure.


We present two new cases, and we review 55 additional cases from the literature.


Report of two cases of male breast cancer after prolonged estrogen treatment for prostatic carcinoma.


The catheter failure was not visualised by plain X-ray nor by filling the pump with radio-opaque solution.


Detection of VZV DNA in blood may be useful for early diagnosis in immunocompromised hosts who present with zoster without skin lesions.


OBJECTIVE: Omeprazole is one of the most widely prescribed gastric antisecretory drugs.


Second cancers including various types of hematological malignancy have been reported in patients with hairy cell leukemia treated with chemotherapy or interferon alfa.


CONCLUSION: A review of the literature shows that this is a particularly uncommon micro-organism.


An oncological consultation recommended 4 mg nebulised morphine and 4 mg dexamethasone in saline as treatment for the bouts of breathlessness.


An infertile patient with amenorrhea-galactorrhea syndrome lost vision during a pregnancy occurring after Bromocryptine treatment.


Post BMT she developed acute grade II graft-vs.-host disease (aGVHD) requiring high-dose steroids and anti-thymocyte globulin.


Pacemaker related endocarditis is a rare potentially fatal condition, most commonly acquired during manipulation of the pacemaker system.


After treatment with recombinant tissue plasminogen activator, the patient's hemodynamic status improved, permitting the liver transplant to be completed.


We describe a 28-year-old man with stage IV-B Hodgkin's disease who developed an adenocarcinoma of the colon after treatment with combination chemotherapy.


Although the enuresis ceased, she developed throbbing headaches, nausea, vomiting, paresthesia, lethargy, fatigue, and altered mental status over the next 7 days.


DISCUSSION: Although there are several reports on extensive passage of lamotrigine into breast milk, this is the first published report of a serious adverse reaction in a breast-fed infant.


In this article, we present a unique case of a 31-year-old woman with severe autoimmune hepatitis apparently abruptly triggered by vaccination.


This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue.


The renal failure in each case was reversed by discontinuation of MP and/or by forced diuresis using albumin and furosemide.


Open biopsy of the affected thoracic vertebrae and surrounding soft tissue were negative for neoplasia.


These patients with limited-stage SCEC were treated at our institution with four cycles of CBDCA and VP-16, either concurrent with radiotherapy for the second two cycles (n = 2) or followed by radiotherapy after the last cycle (n = 1).


When olanzapine was held, the signs and symptoms improved and then returned with rechallenge of olanzapine.


Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN) are mild-to-life-threatening adverse reactions that have been described after exposure to fluoroquinolones.


Two weeks later, anemia, thrombocytopenia and progressive increase in BUN, creatinine and LDH were observed.


The frequent use of neuroleptic drugs in the treatment of disturbed children and adolescents demands that clinicians be aware of the danger of tardive dyskinesia in this age group.


Diazepam abuse in pregnant women on methadone maintenance.


A 60-year-old male patient with ischemic cardiomyopathy experienced an electrical storm 1 month after implantation of an internal cardioverter-defibrillator.


The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.


Amifostine has been found to significantly decrease acute and chronic xerostomia but not mucositis.


The patient developed hypovolemic shock with abdominal pain and distension and further evidence of myocardial necrosis.


We describe two cases of sulfadiazine-induced crystalluria and renal failure in patients with acquired immunodeficiency syndrome, review the pertinent literature, and discuss the pathogenesis.


He denied aspirin or non-steroidal anti-inflammatory drug use.


He was successfully treated with trimethoprime-sulfamethoxazole (TMP-SMX) and meropenem without craniotomy or repeat aspirations.


Clinicians who manage cachectic patients, particularly those with protracted diarrhoea and/or receiving anti-malarial drugs including mefloquine, should be aware of the risk of severe hypoglycaemia.


Five other patients with previous sensitivity to methotrexate, forcing cessation of therapy, were given weekly oral methotrexate and folinic acid every day except the day of methotrexate.


Management and successful desensitization in methotrexate-induced anaphylaxis.


We investigated whether clozapine used as a first-line antipsychotic drug can cause TD.


Management of iatrogenic intravitreal triamcinolone acetonide.


Phenobarbital hepatotoxicity in an 8-month-old infant.


In any case, from a clinical viewpoint, caution should be used when giving venlafaxine to patients with narrow-angle glaucoma, and ocular pressure must be monitored.


One hundred and forty one cases from the literature are reviewed with special reference to patient characteristics, patient treatment, and prognosis.


PURPOSE/OBJECTIVES: To describe the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency, which predisposes patients with cancer to potentially lethal adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy.


We describe eight episodes of reversible acute renal deterioration in five patients with ADPKD, massive renal involvement, and chronic renal insufficiency.


We report the occurrence of spontaneous intracranial bleeding in an human immunodeficiency virus (HIV)-infected adolescent with hemophilia A who was receiving amprenavir (APV).


Scalp video-EEG monitoring was obtained using the standard 10/20 system of electrode placement.


The anticonvulsant drug lacosamide selectively enhances slow inactivation of voltage-gated sodium channels and has been shown to be an effective add-on treatment for partial-onset seizures.


Atrial fibrillation occurring in a patient taking etanercept plus methotrexate for rheumatoid arthritis.


Stent-grafts were constructed from Z stents covered with polyester fabric and were delivered remotely through a catheter under fluoroscopic guidance.


Moreover, treatment with immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha can induce a condition resembling RPLS.


She received 5-fluorouracil, doxorubicin, and cyclophosphamide.


B-cell lymphoproliferative disorders are rare but serious complications of solid organ and bone marrow transplantation.


Successful treatment of rhegmatogenous retinal detachment secondary to globe perforation during peribulbar injection in a case of sympathetic ophthalmia.


She was treated with subcutaneous twice-daily danaparoid (Orgaran) for the remainder of the pregnancy, achieving anti-Xa levels in the therapeutic range 0.5-1.0 IU/ml.


This article reviews the results of all cases of C-TMA reported to date in the English literature and discusses the theories of pathogenesis, clinical features, treatment, and treatment-related complications of the syndrome.


They require immediate discontinuation of the drug and a washout procedure to hasten drug elimination from the body.


Both patients presented with abdominal pain and turbid dialysis effluent with or without fever.


Early detection of such hearing loss is important for providing management options.


Three Alzheimer's disease patients with Pisa syndrome were presented.


Drug-induced immune hemolytic anemia (IHA) is rare but is being reported with increasing frequency.


DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult.


We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.


Hydrocortisone prophylaxis and verapamil therapy were the primary therapies used in patient 1 (the only survivor).


At the time of deterioration all three had reduced HIV viraemia and increased CD4 cell counts.


Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B.


An issue under much clinical debate is whether treatment with two antipsychotic agents simultaneously is advantageous for optimizing response in patients whose previous monotherapy with antipsychotic agents has failed.


We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.


Sweet's syndrome is an acute febrile neutrophilic dermatosis that is a known complication of the administration of filgrastim, a drug that causes increased neutrophil proliferation and differentiation.


He has not had any further episodes of thrombocytopenia to date.


The fifth patient experienced nausea and discontinued treatment after 4 weeks.


Until recently, discontinuance of anticoagulant therapy has been recommended, as this cessation has been shown to slow or halt further tissue infarction.


Used injudiciously, naloxone can lead to withdrawal syndrome, return of severe pain, and other adverse effects.


Anti-thyroid Abs were found positive.


A 53-year-old man developed lower leg edema 4 weeks after rosiglitazone was increased from 4 mg once/day to 4 mg twice/day.


Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.


Considering the possibility of this diagnosis in patients developing confusion and neurological degradation with respiratory alkalosis after intensive chemotherapy, could allow earlier treatment and perhaps improved survival.


We reported a case of disulfiram-induced hepatitis with unique clinical features and compared our case with others in the literature.


In August 2005, he was admitted to a medical facility in the local community with upper gastrointestinal bleeding, and received several units of blood and blood products.


Radiation recall from gemcitabine is rare, but can potentially arise in any site that has been previously irradiated.


Therapy-related myelodysplastic syndrome with der(17)t(12;17)(q13;p13) as a new recurrent cytogenetic abnormality after treatment for chronic lymphocytic leukemia.


Her condition stabilized during treatment with intravenous heparin, aspirin, nitrates, beta-blockers, digoxin, ACE inhibitor and anticoagulants.


The patient made a full neurologic recovery and remains free of disease recurrence 21 months after treatment.


Each procedure reduced the serum level of intercellular antibodies by 50% to 87%.


Eight deaths that occurred during Upjohn-sponsored clinical trials of topical minoxidil and two deaths in subjects who used extemporaneous formulations of the drug are summarized.


These effects can increase the likelihood of its aspiration and subsequent impaired clearance from the respiratory tract.


Acute tumour lysis syndrome (TLS) is a catastrophic complication of the treatment of certain neoplastic disorders.


Also to be considered in the differential diagnosis are multifocal infection and polysynovitis/arthritis of other etiology.


The following is a report of 2 cases of rifampicin-induced renal insufficiency.


A patient was admitted to the intensive care unit because of respiratory failure, and warfarin therapy was started at 2 mg/day for the treatment of pulmonary embolism, together with other medications.


There have only been three reports of Mycobacterium chelonae prosthetic infection of which two cases were associated with total hip arthroplasty and one with total knee arthroplasty and no reports of both Mycobacterium tuberculosis and M. chelonae occurring in the same joint.


Transient acute myopia resulting from isotretinoin (accutane) therapy.


Valproate elimination was enhanced by the continuous infusion of activated charcoal.


Local control of tumor with preservation of organ function was achieved.


We report the case of a 69-year-old patient with metastatic renal clear-cell carcinoma, treated with nephrectomy and three lines of therapy (interleukin-2 plus interferon-alpha2a, vinorelbine plus gemcitabine, and capecitabine), who started a fourth-line therapy with oral sunitinib because of disease progression.


Bisphosphonate-related osteonecrosis of the skull base.


She was successfully treated with intravenous cefoxitin and removal of the indwelling central catheter.


The daily doses ranged from 0.5 to 3 mg.


Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors.


The patient had a favourable outcome.


We report 4 patients with involvement of 5 hips with septic arthritis in established osteonecrotic joints.


RESULTS: A total of 97% were removed after completion of chemotherapy, and 3% because of sepsis or malfunction.


There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density, increase in the incidence of all bone fractures (especially fractures of spine, hip and wrist), joint disorders and increase in the cholesterol level.


The first patient developed a monoarthritis 2 weeks after initiation of IFN-beta, which persisted during the 14 months of therapy and resolved with discontinuation of the medication.


Experimental evidence indicates that corticosteroid administration causes a reduction in T lymphocytes mediated by suppression of cytokines.


Indometacin is reported to improve growth in Bartter syndrome, but not in Gitelman syndrome, where magnesium supplements are recommended.


In addition to being used as adjuvant chemotherapy, S-1 is a promising agent for palliative treatment.


However, raising the dose increases the likelihood of side effects and may significantly compromise patient compliance.


Awareness of this unusual entity will help to avoid misdiagnosis of malignancy or unnecessary thoracotomy.


Controversy exists as to whether making a definitive diagnosis in these patients has an impact on overall outcome.


At its peak the daily protein loss was 35.82 g.


Two cases of malignant hyperthermia (MH) are presented.


We also review the literature describing the spectrum of clinical findings due to intraocular blastomycosis.


The clinical presentation was disseminated varicella infection with multiple organ involvement.


During the first days of arsenic trioxide treatment a rapid decrease in the D-dimers was seen (normal values reached until day 7), together with a slight decrease in peripheral blood leukocytes.


Neutrophilic eccrine hidradenitis mimicking cutaneous vasculitis in a lupus patient: a complication of cyclophosphamide.


Arginine has been shown to shift potassium from cells to the extracellular compartment, an effect directly related to its serum concentration.


Sibutramine, a serotonin reuptake inhibitor, currently is used in treatment of obesity.


Of the four patients who responded to HU with an increase in total Hb, all reported symptomatic improvement and three have not required further transfusions.


Scans were performed without opioid drugs and 30 minutes after intramuscularly administered meperidine, morphine, hydroxyzine, hydroxyzine plus meperidine, butorphanol, and nalbuphine.


In addition, patients with blebitis should be observed closely to identify extension into the vitreous cavity so that intravitreous antibiotics can be administered in a timely fashion.


The neurological complications may be reduced by earlier recognition and better understanding of their etiopathogenesis.


CASE SUMMARY: A 57-year-old female with cardiomyopathy and "sulfa" (trimethoprim/sulfamethoxazole) allergy documented as pancreatitis presented with symptoms consistent with pancreatitis after use of furosemide.


METHODS: The human leukocyte antigen (HLA) typing of peripheral leukocytes was studied by lymphocytotoxicity technique.


A case of acute respiratory failure due to diaphragmatic weakness following adalimumab therapy for psoriasis is described.


CASE SUMMARY: A 39-year-old white Jewish schizophrenic man treated with olanzapine developed an elevated serum CK concentration with a peak concentration of 4000 IU/L (normal < 230).


Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.


METHODS: A patient who developed dramatic, permanent vision loss after a 9-month course of treatment with ethambutol and isoniazid for pulmonary tuberculosis is presented.


METHOD: A patient with acquired immunodeficiency syndrome (AIDS) with pulmonary Pneumocystis carinii was treated with 750 mg of atovaquone three times a day.


Unfortunately, not all patients respond to these treatments.


A Group IVC AIDS patient experienced repeated methicillin-resistant Staphylococcus epidermidis colonization and infection of his central venous access device.


We describe a patient with metastatic prostate cancer who developed nonoliguric renal failure during treatment with suramin.


We postulate that the bolus of sulprostone resulted in possible coronary spasm that resulted in cardiac arrest.


We review the pathophysiology of prophylaxis-related encephalopathy in leukemia patients and summarize its clinical, histological, and radiological characteristics.


Although she immediately improved following abortion (within 2 hr, peak airway pressure fell from > 70 to 38 cmH2O, without change in plateau pressure), superimposed morbidities improved more slowly, and the patient made a complete recovery.


Since no satisfactory remission was achieved using a multi-drug chemotherapy protocol that included cyclophosphamide, vincristine, cytosine arabinoside, prednisolone, and subsequently supplemented by L-asparaginase, it was replaced by another protocol combining vincristine, L-asparaginase, prednisolone, cyclophosphamide and doxorubicin.


Although its side effects are few, tamoxifen increases the incidence of proliferative lesions of the endometrium, which theoretically should be preventable with progestational agents.


The individual drug responses vary and no recommended standard doses exist.


The most common symptom was pain (93%).


Analeptic-induced paranoid psychosis occasionally occurs in the treatment of narcolepsy.


Complete dissolution was achieved with a combination of i.v. tissue plasminogen activator and heparin.


Subsequent observation revealed the presence of choreiform movements.


An unusual case of chronic coronary artery dissection: did cisplatin play a role?


We present a retrospective analysis of 4 HSCT recipients who survived long-term artificial respiration subsequent to pulmonary mycosis, and compare our current findings with historic data.


Discontinuation of MMF was followed by a rapid and spontaneous rise in neutrophils in two patients.


There is evidence that the angiotensin II receptor antagonist, losartan, increases urate excretion by reducing reabsorption of urate in the renal proximal tubule.


Portal vein thrombosis was diagnosed in 2 patients.


Post transplant lymphoproliferative disorder (PTLD) involving the brain was seen in 2% of the liver allografts, 3% of the heart, and 7% of the heart-lung recipients.


Histopathology of the thyroid in amiodarone-induced hypothyroidism.


Drug-induced hypersensitivity syndrome (DIHS) is one of the most severe drug adverse reactions, with characteristic biphasic symptoms.


Our case reminds the clinicians that the adverse and proarrhythmic effects of dofetilide can occur due to changes in the arrhythmic substrate during acute severe ischemia.


We describe the case of a premature baby who developed a rapidly expanding aneurysm of the descending thoracic aorta, secondary to a highly placed infected umbilical catheter.


Methotrexate-induced papular eruption following treatment of psoriasis.


Hepatic portal sclerosis (HPS) alone was observed in 1 patient, nodular regenerative hyperplasia (NRH) alone in 2 patients and combined HPS/NRH in 3 patients.


Bronchoscopy guided transbronchial lung biopsy revealed interstitial thickening and type II pneumocyte activation, compatible with interstitial pneumonitis.


Despite severe thyrotoxicosis, combined IFN-alpha and ribavirin therapy was continued and radioiodine treatment was considered for Graves' disease.


A syndrome of microangiopathic hemolytic anemia, renal impairment, and pulmonary edema in chemotherapy-treated patients with adenocarcinoma.


After discontinuation of the treatment, gradual decline of bone mineral density at lumbar and femoral sites was detected with serial DEXA measurements.


In this report, we assess the possibility that exposure of the angle-supported AC IOL haptics caused the endophthalmitis.


We conclude that (a) cyclophosphamide is a human teratogen, (b) a distinct phenotype exists, and (c) the safety of CP in pregnancy is in serious question.


Other laboratory studies, including urine pH, anion gap, titratable acidity, and bicarbonate, showed a distal tubular acidification defect.


After switching to a barbiturate-free schedule, his condition continued to be unstable for more than 21 MPB half-lives (approx. 30 days) and did not stabilize until MPB-metabolites dropped below their urinary detection limit.


This happened despite a very short course of therapy in two patients.


The authors propose that differential involvement of dopamine systems may account for the transition from akathisia to tardive dyskinesia.


However, thin conjunctiva is susceptible to mechanical injury and is difficult to repair with suturing, especially when the point of leakage is close to the scleral flap.


After both patients gave informed consent, an uneventful intravitreal injection of 1.25 mg Avastin was performed in the left eyes.


Pretreatment best-corrected visual acuities ranged from 20/40 to 20/400 (mean, 20/70 using Snellen fractions) and improved two to eight (mean, five) Snellen lines, to a range of 20/20 to 20/50 (mean, 20/25).


Veno-occlusive disease of the liver after lung transplantation.


Bilateral acoustic (VIII) nerve palsy in this patient was most likely a manifestation of vincristine neurotoxicity.


A rare case of anterior chest closure only with omental flap after devastating mediastinitis: case report.


Patients stabilized on glyburide who are started on a fluoroquinolone should have their glucose levels monitored closely.


When retested 3 months later, at which time the serum T4 was 5.5 micrograms/dl, the patient was somewhat less hypothyroid and there was an exaggerated TSH response to exogenous TRH, indicating recovery of pituitary TSH reserve.


Although adverse reactions to protamine are reported infrequently and are usually mild, we recently observed the first fatal case of type I anaphylaxis resulting from protamine.


All target symptoms disappeared in the patients after an average of (mean+/-S.D.) 24.5+/-18.1 days.


We believe this to be the first culture-proven case of L. micdadei PVE reported in the literature.


Life threatening laryngeal toxicity following treatment with combined chemoradiotherapy for nasopharyngeal cancer: a case report with review of the literature.


All four patients had pericardial abnormalities on echocardiography prior to receiving gemcitabine.


DESIGN: Case report.


These data indicated that infliximab possibly triggered production of granulocyte and neutrophil autoantibodies with resultant autoimmune agranulocytosis.


Bortezomib-induced paralytic ileus is a potential gastrointestinal side effect of this first-in-class anticancer proteasome inhibitor.


We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.


The temporal course of the porphyrin abnormality suggested that cyclophosphamide was the pathogenic agent, and symptoms regressed after cessation of this drug with continued administration of cisplatin.


Two patients developed hypersensitivity to nitrosourea compounds.


Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.


In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.


There are, however, obligations on the dentist to ensure the accuracy of information the patient gives and to ensure that patients whom they believe are at risk follow their advice.


In patients who show abnormal liver function tests, the immediate discontinuation of gliclazide is recommended.


Comorbid alcohol dependence is common in patients with schizophrenia and is associated with a variety of serious adverse consequences.


The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.


This is the first case, to our knowledge, of onset of prolonged infliximab-induced lupus.


The patient was discharged with a diagnosis of HCV-related active chronic hepatitis, skin porphyria, and type 2 diabetes.


Thiazide-induced lichenoid photosensitivity.


CASE SUMMARY: A 37-year-old Hispanic man with diabetes mellitus, ethanol abuse, and recent crank use developed a venous thrombosis and possible pulmonary embolism, followed by acute liver and renal failure requiring continuous veno-venous hemofiltration.


Because of the presence of hemolysis, the patient underwent testing for glucose-6-phosphate dehydrogenase (G6PD) deficiency, for which he tested positive.


RESULTS: The number of days each patient received mecamylamine varied from 8 days to 550 days; with nine patients more than 200 days, six patients from 100-200 days, five patients for 50-100 days, and four patients 0-50 days.


A case of high-grade endometrial stromal sarcoma, confined into an intrauterine polypoid growth, in a woman with a history of breast cancer who was treated with adjuvant tamoxifen.


CONTEXT: Acute pancreatitis has been reported in a few cases treated with macrolides or glucocorticoids.


The potential for progressive brain injury and subsequent disability related to intraventricular IL-2 therapy is discussed.


Three days after administration began, serum CPK levels had become markedly elevated to 10,897 mg/dl and myoglobinuria was detected (1,800 ng/dl), suggesting the presence of rhabdomyolysis.


Avascular necrosis (or osteonecrosis) is a very rare extraintestinal osseous complication that may occur in Crohn's disease, independent of previously reported risk factors, including corticosteroids or parenteral nutrition with lipid emulsions.


Using a ventricular reservoir to instill amphotericin B.


Forty-eight hours later a commercially available cylindrical diffusing laser fiber was inserted into an 8F biliary catheter equipped with a 0.038 inch side-hole at its distal tip.


On March 13 the patient was again admitted for worsening CHF and was started on continuous dobutamine infusion.


A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.


Until today, many kinds of complications have been reported in the literature.


Clinicians should be aware of the signs and symptoms of neurotoxicity during treatment, as well as predisposing factors that put patients receiving methotrexate at risk for neurotoxic effects.


The possibility of a recrudescence of a persisting infection was rejected.


Intravenous ribavirin was obtained and administered for 5 days without success; the patient's mental status deteriorated rapidly and she died on day 69 post-transplant.


Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.


Tolerance to phenelzine and subsequent refractory depression: three cases.


We assume that the clinical picture was mainly dictated by flecainide intoxication.


RESULTS: Visual acuity was reduced to 1/50 and 0.3.


Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.


DISCUSSION: SIADH has been reported as a complication of treatment with vinca alkaloids.


Clinical features include an acute, symmetrically progressive polyneuropathy, focal or generalized myokymia and a tendency for initial neurological deterioration followed by improvement, after cessation of chrysotherapy.


There was initial clinical deterioration while in vitro data indicating that the organism was sensitive to vancomycin with a minimum inhibitory concentration of 0.5 micrograms/ml.


With the extensive use of platinum-based chemotherapy regimens, either alone or in combination with radiation therapy in the management of gynecological malignancies, this uncommon complication should be kept in mind for early detection and successful management.


After returning to a normal level of greater than 100,000/mm3, the patient's platelets again dropped to 1200/mm3 with readministration of rifampin.


Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).


With the progression of immunoreconstitution, the lesions healed spontaneously.


However, this mechanism may fail under certain circumstances, in particular if D2 dopamine antagonism exceeds a certain threshold.


A third case of acquired phosphate diabetes associated with a syndrome of inappropriate secretion of antidiuretic hormone (SIADH), related to a pulmonary tuberculosis, is reported.


This therapeutical regimen was chosen--in accordance with cardiac surgeons, cardiologists, and interventional radiologists--due to the high risk of adverse event after repeated surgery in this particular patient.


We describe the first case of a Chinese liver transplant recipient with PVB19-induced PRCA during immunosuppressive therapy.


This hypersensitivity response cannot be explained pathophysiologically by any mechanism.


She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.


Active vitamin B12 contains cobalt in its reduced form (Co+).


We present the case of a 67-year-old depressed woman who began treatment with citalopram.


Hepatic uroporphyrinogen decarboxylase activity is markedly reduced in patients with this disorder.


Two of the five patients who worsened motorically also developed encephalopathy during risperidone treatment; the encephalopathy resolved when the patients were switched to clozapine treatment.


A diagnosis of phenytoin toxicity was made and she was treated by withdrawing the medication.


Patients taking multiple medications may suffer from unpredictable and complex drug-drug interactions resulting in significant morbidity and mortality.


The role of heparin therapy.


The duration of pain was 17.8 +/- 9.3 months (mean +/- SD), and the baseline VAS score was 88.2 +/- 6.3 points.


Wernicke encephalopathy and beriberi during total parenteral nutrition attributable to multivitamin infusion shortage.


His serum transaminases were slightly elevated and hepatic hyperechogenicity was observed on ultrasonography.


A female patient with HER2 positive, metastatic breast cancer presented with pulmonary infiltrates, and a plural effusion dyspnoea after several months of trastuzumab treatment.


The outcome of 19 other children with severe aplastic anemia who received ATG was also summarized.


In this case, unlike those previously reported, hyponatremia recurred 5 months after switching from citalopram to mirtazapine, which is believed to be a safe antidepressant.


Medical treatment of fungal endocarditis on prosthetic valves can be successful in selected cases.


Both colchicine and statin therapy may be associated with myopathy, which usually occurs after several months of therapy.


Rituximab-based therapy for gemcitabine-induced hemolytic uremic syndrome in a patient with metastatic pancreatic adenocarcinoma: a case report.


Open-lung biopsy revealed numerous lipid-laden macrophages and multinucleated foreign-body giant cells.


Before receiving PUVA therapy one patient had been treated with topically applied thiotepa and x-ray irradiation, while in the other patient PUVA was the only treatment received except for topical corticosteroids.


Although a lot of amiodarone-induced torsades de pointe have been published, a review of all these cases and the underlying risk-factors has never been made.


Isoniazid induced gynaecomastia: a case report.


It usually occurs in patients with impaired renal function or when allopurinol is prescribed with a thiazide diuretic.


A woman with a prolonged unipolar delusional depressive episode, unresponsive to antidepressant treatment, experienced rapid improvement of depressive and psychotic symptoms following the occurrence of two grand mal seizures.


Another approach involves minimal debridement of the cartilage and letting the wound mature for 6 to 8 months.


Treatment with low-molecular-weight heparin followed by a heparinoid resulted in slow healing of the ulcers but also allowed the subcutaneous interferon injections to be continued.


Sometimes the presentation is with diabetic ketoacidosis, requiring insulin treatment, which can nevertheless be reversible.


A 65-year-old man on warfarin therapy with a sudden spontaneous onset of sub-conjunctival haematoma associated with bloody tears was assessed in the clinic following a referral from an optometrist.


Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.


Sustained-release procainamide-induced reversible granulocytopenia after myocardial infarction.


When he was given an inferior alveolar nerve block, excessive bleeding was noted at the injection site and the dentist advised the patient see an oral and maxillofacial surgeon.


Due to its low volume of distribution (0.6 L/kg), low protein binding (about 15%) and water solubility, acyclovir is an example of the ideal drug that can be removed by hemodialysis.


He was afebrile, tachycardic, and tachypneic and had an oxygen saturation of 94% while breathing room air.


We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.


We concluded that the recurrent bacteraemia in this predisposed patient was due to re-infection, and that antibiotic treatment (amoxicillin plus an aminoglycoside) resulted in a complete eradication of the infective microorganism.


Abnormally high urine and bone fluoride confirmed the diagnosis.


Although isoproterenol has been the mainstay of therapy for chronotropic support in this setting, its availability has been an issue in recent years.


When there is an alteration in the binding of the anticonvulsant drug to the plasma proteins, however, the relationship between the serum concentration and therapeutic efficacy or toxicity becomes difficult to interpret.


Flecainide acetate is a sodium channel blocker and a class Ic antiarrhythmic agent with potential life-threatening proarrhythmic and cardioinhibitory properties when taken in overdose.


Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.


OBJECTIVES: To describe the presentation and treatment of acute isoniazid (INH) neurotoxicity appearing at an inner-city municipal hospital.


This idiosynactic adverse reaction has not been previously described.


Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as "red man syndrome" and anaphylaxis.


CONCLUSIONS: We report a typical symptoms of Charles-Bonnet syndrome (CBS) in patients with severe AMD after intravitreal Avastin-injections.


This increase when clozapine was switched to risperidone and vice versa is consistent with our previous report of elevated serum triglyceride levels in clozapine-treated patients.


The neuropathological changes had features similar to those seen in leukoencephalopathy with intrathecal administration of methotrexate.


We tested 136 unrelated patients with familial parkinsonism for SCA2 mutations.


Clinicians should be aware of factors that affect A1C values, specifically erythrocyte life span.


RESULTS: Exposure to the vanadium containing catalyst for 120 minutes resulted in a sustained decline in forced vital capacity and forced expiratory volume in one second, while the transfer factor for carbon monoxide did not change significantly.


Shewanella spp. are an uncommon cause of human infection, with exposure to water being the commonest source.


We present a case of hemorrhagic stroke after cesarean delivery under combined spinal-epidural anesthesia in an 35-year-old Hispanic patient treated with anticoagulants for protein C deficiency.


We describe a patient who experienced chronic nausea and an episode of confusion while treated with a small, stable dose of oral morphine in the setting of mild renal insufficiency.


Concomitant administration of lithium with olanzapine may place patients at risk for NMS.


Acute pancreatitis is a known, although rare, complication of mesalamine treatment.


Propafenone's distribution, clearance, and structural similarity to propranolol contribute to its central nervous system effects.


We report here the case of rituximab administration during the first trimester of pregnancy in a woman with autoimmune hemolytic anemia.


Clonidine, oral and patch, has been used in adults for the treatment of hypertension and Tourette's Syndrome.


DESIGN: Two interventional case reports.


During her third cycle, she again received cisplatin 100 mg/m2 over 30 minutes and developed palmar pruritus, urticaria, and edema.


Epinephrine and dobutamine were stopped, and norepinephrine (noradrenaline) was successfully used to control the hypotension.


Identification of the antigenic determinants of FDE-inducing drugs will make predicting safe alternatives in patients with FDE an easier task.


They were treated with cyclophosphamide for 98 and 44 months respectively.


Three weeks later he died of Clostridium septicum sepsis caused by necrotizing enterocolitis.


We point out this case for its striking clinical picture and well-documented relation to immunoreconstitution to draw attention to this IRIS manifestation.


A diagnosis of aquagenic syringeal palmar keratoderma was made on the basis of these clinical and histopathologic findings.


Rhodococcus equi has emerged as an opportunistic pathogen usually causing necrotizing pneumonia in immunosuppressed patients but has been found increasingly in extrapulmonary sites.


Treating physicians must be aware of this potential toxicity from gemcitabine either given concomitantly or followed by radiation.


A 50-year-old diabetic and hypertensive male patient is reported who had ticlopidine-induced marrow aplasia partially responsive to colony-stimulating factors and corticosteroids, but experienced complete recovery with cyclosporine.


Similar occurrences in outpatients reported in the literature are reviewed.


We report a patient with recurrent, increasingly severe episodes of PPE, ultimately complicated by a severe bullous eruption, following successive cycles of high-dose cytarabine for the treatment of acute lymphoblastic leukaemia.


After 25 months there had been no recurrence of gastrointestinal bleeding.


The likelihood of an acute respiratory reaction during treatment may therefore depend on the bacillary load, the extent of lung disease present, and its severity may be related to the pre-treatment immune status of the patient.


The striatum, especially the putamen, has been considered to be responsible for dystonia.


The clinical diagnosis of lichen planus (LP) was confirmed by histology, which revealed hyperorthokeratosis, hypergranulosis, vacuolar degeneration of the basal layer cells and a dense, band-like lymphocytic infiltrate in the superficial dermis.


A life-long antiretroviral treatment of congenital HIV disease, associated with a mixed fat redistribution syndrome and osteopenia already occurred during pre-pubertal age.


STUDY DESIGN: Case report of Baclofen pump catheter failure investigated by radioisotope injection.


Chronic paroxysmal hemicrania (CPH) is a rare primary headache syndrome, which is classified along with cluster headache and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) as a trigeminal autonomic cephalalgia.


We conclude that routine therapeutic application of G-CSF in afebrile severe ATDIG is not justified, and in some cases may generate a cascade of iatrogenic adverse events.


ITO is a rare but curable tumor of the ovary using combination chemotherapy.


RESULTS: The first patient required admission to the hospital for medical stabilization.


Monoamine oxidase inhibitors are rarely used in this population, although much evidence and clinical experience would indicate that they can be extremely effective and non-toxic.


Unusual causes of peritonitis in patients undergoing continuous peritoneal dialysis with emphasis on Listeria monocytogenes.


The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.


At 24 months of age the infant's neurodevelopment was normal.


However, the patient later succumbed to her leukaemia.


These nail changes gradually disappeared when the dose of clofazimine was reduced.


OBJECTIVE: To report the finding of squamous metaplasia within endometrial glands occurring as a result of progestin therapy of hyperplasia.


We also discuss the apparent increased thrombotic risk in patients receiving a VAD for chemotherapy induced cardiomyopathy and the implications this may have for the choice of VAD.


This calls for adequate evaluation and monitoring of patients on this drug.


The therapeutic implications of this clinical sequence are discussed.


We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia.


AIMS: To present a case of piloerection after replacing fluvoxamine maleate with milnacipran hydrochloride, and to analyse this effect based on receptor occupancy theory.


This small series of adult patients with leukaemia illustrates difficulties in treating patients who are practising JW, yet nevertheless provides a significant argument against the prejudicial decision leading to evasion of treatment in these patients.


We report two cases that developed acute myeloid leukaemia (AML) during tamoxifen therapy for breast cancer.


New therapeutic approaches are therefore warranted.


Intravenous pyelogram performed 20 months later following an episode of left-sided colicky pain showed right-sided papillary necrosis.


Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.


Diagnosis, treatment, observation and outcome of fetal supraventricular tachycardia in a twin pregnancy.


We report herein the case of a 69-year-old Japanese man with acquired von Willebrand syndrome associated with monoclonal gammopathy of undetermined significance who developed IgG1-kappa antibodies against von Willebrand factor (VWF).


This case report illustrates the neurotoxicity unique to HDARAC.


We describe a continuous infusion regional analgesic technique for pain due to sternal fracture.


The specimen showed no viable tumor in association with an extensive granulomatous response in both the breast and axillary lymph nodes.


As of May 28, 2004, to our knowledge, this is the first reported case of rhabdomyolysis following C. mukul ingestion.


RESULTS: The production of TNF-alpha and IL-6 by the macrophages of the patient in presence of insulin were dramatically increased in comparison with control subjects.


The disease predisposes to severe vincristine neurotoxicity.


Following therapy with ABLC her fever abated, her chest X-ray findings improved, and her hepatic function tests improved with eventual resolution.


After electrolyte supplementation and discontinuation of foscarnet, the symptoms resolved and laboratory indices returned to normal.


A total gastrectomy with omentectomy and resection of the distal oesophagus in a 69-year-old haemophilia A patient with high inhibitor of 128 Bethesda units is described.


With the help of intensive supportive care and symptomatic treatment, the patient recovered and was discharged home after a hospital stay of 25 days.


Cefoxitin-associated renal failure.


Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide.


After seven months' continuous treatment for suspected tuberculosis with rifampicin and ethambutol a nine-year-old boy developed polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor.


Physicians should be aware of this type of reaction.


This was the patient's first experience with trimethoprim- sulfamethoxazole, and he was not taking any other medications during the treatment period.


Among reported cases of CAPD-related peritonitis due to molds (22 Aspergillus spp. and seven zygomycetes), previous bacterial peritonitis was a common event, the related mortality associated with Aspergillus and zygomycetes was 27% and 57%, respectively, prompt removal of the Tenckoff catheter was critical for survival, and most patients were not able to resume CAPD.


The second was an 82-year-old man receiving ticlopidine for 2 years when, during a febrile episode, he was found neutropenic with marrow aplasia.


Two weeks after admission, she developed signs of WE including diplopia, ophthalmoplegia, nystagmus, and memory disturbance.


PURPOSE: To describe the clinical and electrophysiological findings in a young boy with decreased vision possibly due to retinal damage by rifabutin.


If opioid drugs are administered before a diagnostic hepatobiliary scan, delayed clearance of Tc-IDA from the common bile duct might lead to an erroneous diagnosis and indicate a potentially unnecessary common bile duct exploration.


In a MEDLINE search (1966 to present, English language, keywords: amniocentesis, chorioamnionitis), no report of Candida chorioamnionitis after serial reduction amniocentesis exists.


A 62-year-old woman with chronic active hepatitis receiving immunosuppressive drugs was initially admitted with sepsis secondary to an intra-abdominal abscess caused by Klebsiella pneumoniae.


The girl is alive 23 months after transplantation with complete donor chimerism; both Ph chromosome and bcr/abl RNA are negative.


The hepatic enzyme disturbances normalized after discontinuation of pegvisomant.


Hyponatraemia developed after rechallenge with controlled release carbamazepine.


A case is reported of theophylline intoxication due to a dramatic decrease in theophylline clearance following concomitant administration of viloxazine.


BACKGROUND: Primary cutaneous B-cell lymphoma (CBCL) is characterized by restriction to the skin, a high incidence of recurrence after various treatment modalities, and a variable but mostly favorable prognosis.


SETTING: Hospital-based pathology laboratory processing inpatient and outpatient specimens.


APOLT restored the plasma FH level, without HUS recurrence, for 7 months.


Three days after receiving intravitreal injection of bevacizumab (1.25 mg in 0.1 ml), he developed acute vision loss and change of consciousness.


Detection of ganciclovir resistance after valacyclovir-prophylaxis in renal transplant recipients with active cytomegalovirus infection.


Cough mixtures: not always for cough.


Postoperatively, the first two patients treated with 1 to 2 cc of thrombin were slow to awaken; one had evidence of vasospasm by transcranial Doppler ultrasound studies and multiple infarcts on cranial computerized tomography, while the other had a moderate-sized frontal hematoma with intracranial hypertension.


Acute drug induced hepatitis due to erlotinib.


This panic anxiety was not relieved by taking etizolam and flunitrazepam again, but subsided rapidly by the re-administration of mianserin 30 mg/day, and because of that the depressive symptom also disappeared.


There were also larger cells (immunoblastic shape) that displayed CD20 positively, some scattered plasma cells, and eosinophils.


PURPOSE: To report a case of bilateral Acanthamoeba keratitis with late, atypical recurrence after penetrating keratoplasty a chaud.


This association has been reported less frequently with tacrolimus.


Our report suggested that CBDCA hypersensitivity was correlated with the total dose of previously administered platinum agents and that CBDCA should be excluded in patients who have received multiple platinum-based chemotherapy, even in platinum-sensitive cases, because CBDCA hypersensitivity can occur even with low-dose CBDCA administration.


Selective arterial catheter angiography showed an acute occlusion of the posterior tibial artery.


BACKGROUND: Reduction amniocentesis is used in cases of severe polyhydramnios to decrease maternal discomfort and the risk of preterm labor.


Metoclopramide-induced parkinsonism.


Abrupt, accidental withdrawal of trihexyphenidyl triggered severe exacerbation of the cranial dystonia associated with inspiratory stridor and acute respiratory difficulties, prompting emergency admission.


A 40-year-old Caucasian female was first seen 20 years ago for a routine ocular screening in relation to hydroxychloroquine treatment for systemic lupus erythematosus.


The location and extent of the central nervous system pathology correlated with the type and severity of clinical symptoms.


The site of thrombosis and the chronological relationship with the IIR implicates a hypersensitivity to infliximab in the causation of the venous thrombosis in this case.


Diffuse cutaneous leishmaniasis associated with the immune reconstitution inflammatory syndrome.


The authors present histologic confirmation of CNS granulomatous angiitis in a child with chronic GVHD after BMT.


Cardiac toxicity related to BCNU has not been described well.


A 10-year-old girl who presented to our hospital was diagnosed as having B-precursor cell acute lymphoblastic leukemia.


We report the case of a 32-year-old man whose monotherapy with various antipsychotic agents failed.


PATIENTS: A male infant born by cesarean section with a birth weight of 2.6 kg.


Here, we report a case of RFP-induced hypothyroidism without underlying thyroid disease.


Fatal hepatitis after long-term pulse itraconazole treatment for onychomycosis.


The primary outcome measure was angiographic resolution of CMO.


This case study presents a situation in which a loss-of-resistance technique resulted in an inadvertent discogram.


Patient had seizures and developed failure.


Symptoms and signs of augmentation were related to low plasma levodopa levels, abating 75 minutes after oral levodopa administration and reappearing after 3 hours, closely mirroring the rapid rise and fall of plasma levodopa concentration.


Lithium is known to cause acute renal failure and tubulo-interstitial disease, but the recently described association with proteinuria or nephrotic syndrome is little recognized.


Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case.


Diagnosis was suggested by clinical history and radiographic findings, but the bronchoalveolar lavage plays an important role both in excluding infectious agents and in providing information for understanding the pathogenesis of lung injury.


Pulmonary capillaritis as a manifestation of acute humoral allograft rejection following infant lung transplantation.


Reversible pheripheral edema in female patients taking proton pump inhibitors for peptic acid diseases.


SCA2 may present as levodopa-responsive parkinsonism.


Medical treatment of a grossly enlarged adenomyotic uterus with the levonorgestrel-releasing intrauterine system.


Risperidone may also be useful for treating acute agitation in patients with a high risk of EPS and for long-term treatment of "sundowning" (agitation and confusion starting in the late afternoon and worsening at night).


A patient with recessive generalized congenital myotonia and severe, disabling weakness underwent various forms of treatment while being monitored electrophysiologically.


RESULTS: In a 22-year-old Thai woman with Graves' disease, tinnitus, hearing impairment in the left ear (with progression to the right ear), and vertigo developed after 3 years of therapy with PTU.


CPH is exquisitely responsive to indomethacin so much so that the response is one of the current diagnostic criteria.


Because of the specifics of the clinical history, we were unable to ascertain whether this complication was due to a single antibiotic or to the combination.


DISCUSSION: Methotrexate-induced papular eruption is rarely reported shortly after beginning methotrexate therapy in patients with acute exacerbation of collagen vascular diseases.


A brief literature review is provided to assist in explaining the mechanisms by which clinically significant cerebral edema may develop.


The abscess was treated with aspiration and appropriate antibiotic therapy and its complete resolution was confirmed by CT scan.


A 53 year old Greenlandic male was admitted twice over a period of 4 years with a new complete right bundle branch block after ingestion of 10 g and 4 g of carbamazepine respectively.


Neurological problems are a frequent occurrence in patients given this therapy, particularly cerebellar ataxia, but the development of bulbar and pseudobulbar palsy has not been reported.


This paper investigated the relationship between measurable personality factors and level of effects shown to cyclazocine and placebo in a controlled study.


On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis.


This is the first report of acute kidney injury due to zonisamide-induced DRESS/DIHS.


A thorough hematologic examination revealed von Willebrand's disease, which the patient was not aware of.


MRI has a high sensitivity and specificity in the diagnosis of osteonecrosis and should be used when this condition is suspected.


In the 27 late cases, Streptococcus species and gram-negative organisms comprised 48% of isolates; of 33 cases of endophthalmitis, 15 (45%) demonstrated no growth on vitreous culture.


CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.


A 36-year-old man presented with small-bowel obstruction secondary to a large, diffuse mesenteric desmoid six years following colectomy and ileoproctostomy.


This syndrome generally occurs after a few weeks of therapy and may occur after L-asparaginase therapy is completed.


Rapid identification of speech loss linked to FK506 may be important because reduction or cessation of the drug may be associated with reverse of speech loss.


We report on a 56-year-old female who exhibited drug refractory paroxysmal atrial fibrillation, in which marked prolongation of the QT interval and T wave inversion on electrocardiogram was demonstrated reproducibly shortly after the administration of oral pirmenol therapy.


However, because only a small proportion of the baclofen penetrates into the central nervous system when administered orally, we tested whether it is possible to increase the efficacy of treatment by continuous intrathecal infusion of baclofen (CITB) in a patient with severe tardive axial dystonia unresponsive to conventional therapy.


A pyogenic, ruptured Baker's cyst induced by arthroscopic pressure pump irrigation.


Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia.


Somatostatin can be helpful after liver transplantation in some well-defined indications.


Perospirone has a uniquely high affinity for serotonin-1A receptors, and it could be speculated that perospirone, as a serotonin-1A receptor agonist combined with SDA, may have greater efficacy for treatment-refractory symptoms of schizophrenia.


Symptoms began during a course of IFN alpha, resolved with its suspension, and recurred on rechallenge.


Herein, we describe 2 patients who developed unusual CD8+ cutaneous lymphoproliferative disorders after treatment with efalizumab and infliximab.


Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl.


CONCLUSIONS: Findings in our patient strongly suggest that a secondary inflammation reaction caused by the destruction of the cysts might have enhanced the process of endarteritis.


Type I, blue-black pigmentation confined to sites of scarring or inflammation on the face; Type II, blue-grey circumscribed pigmentation of normal skin of the lower legs and forearms; and Type III, diffuse muddy brown pigmentation of normal skin accentuated in sun-exposed areas.


Other risk factors for prolonged QT interval such as underlying cardiac abnormalities, electrolyte disturbances, and concurrent medications should be sought, and all patients should be monitored with serial ECGs even when methadone doses remain stable.


A patient with nephrotic syndrome developed pseudotumor cerebri following glucocorticoid therapy.


Albendazole-induced pseudomembranous colitis.


Oculomotor recordings revealed frequency locked voltage dependent vertical or oblique movements of the eye ipsilateral to the active contact, suggesting current spreading to the mesencephalic oculomotor fibres.


Lithium carbonate did not prevent the tricyclic-induced rapid cycling, although two patients subsequently responded well to lithium carbonate alone.


This case emphasizes the importance of proper work-up of patients with apparently progressive lymphomas.


MK-0457 has in vitro activity against cells expressing wild-type or mutated BCR-ABL, including the T315I BCR-ABL mutation.


CONCLUSIONS: The results of our study suggest that the pharmacokinetics of parent ifosfamide may not be substantially altered in patients with renal failure.


CDT appears to be a useful modality in managing difficult cases of free-flap salvage.


When L-dopa reduction was feasible, it resulted in cessation of unsafe driving.


We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).


We know of no other reported cases of spontaneous muscle necrosis in association with diabetes insipidus and feel that there should be increased awareness of the association between the two.


Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are severe life-threatening dermatologic conditions.


The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.


She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.


Hypogammaglobulinemia associated with gold therapy: evidence for a partial maturation blockade of B cells.


None reported seeing all PPP components, and four saw only the information on the pill packet.


Photobiological evaluation revealed a strongly positive photopatch test to quinine sulfate and a marked persistent reduction in the minimal erythema dose to solar-simulated radiation in the uninvolved skin.


These findings are consistent with an immune-complex form of glomerulopathy in which gold is neither the antigen nor a hapten in the glomerular deposits, and they suggest the hypothesis that antibodies to tubular epithelial antigens induced by gold therapy may be a causative factor in the renal disease associated with gold therapy in rheumatoid arthritis.


Antipsychotic drugs can cause neutropenia, which can progress to life-threatening agranulocytosis if drug therapy is not interrupted.


Clindamycin for treatment of Toxoplasma polymyositis in a dog.


We examined the correlations between the individual changes in serum creatinine (Scr), body weight (BW) and urine volume (UV) before and after the pulse therapy and other laboratory data such as Scr, total serum protein and albumin.


A small part of TGA has a familiar occurrence.


Cultures of cutaneous biopsies grew Alternaria sp.


We report a case of acute hyperphosphatemia secondary to rectal administration of sodium phosphate and sodium biphosphate (Fleet enema).


Dosing adjustments need to be considered in these patients.


Polysomnographic and pharmacokinetic findings in levodopa-induced augmentation of restless legs syndrome.


In this case, the dose was slowly reduced after delivery, and the maternal lamotrigine serum concentration more than doubled in the week before the neonatal apneic episodes.


In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage.


SUBJECTS AND METHODS: Our case observations attempted to evaluate nine alcoholics after withdrawal suffering from persisting craving, sleep disorder, excitement, depressive symptoms or anxiety symptoms.


A 71-year-old woman who had critical cerebral ischemia secondary to a carotid artery occlusion was receiving high-dose intravenous phenylephrine for a trial of hypertensive therapy.


The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible in medical literature.


His lung cancer recurred 10 months later, when he was found to have bone metastases.


We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.


At present, the child is growing on by GH replacement therapy.


Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis.


S-A conduction through two pathways, the first with 2/1 block the second having 0.12-0.14 s longer conduction time and with occasional 2/1 block was proposed for the explanation of the alternating P-P interval and other electrocardiographic features seen.


Acute Liver Failure Study Group.


Schneiderian first-rank symptoms associated with fluvoxamine treatment: a case report.


The course of this rare case is described and the literature reviewed.


We believe that mucositis was a contributing factor to this case of fatal hyperkalemia after administration of succinylcholine, with a mechanism similar to that reported with thermal injury.


We have successfully overcome severe neutropenia in an RA patient treated with gold salts, using granulocyte colony-stimulating factor (G-CSF), reducing the duration of neutropenia and risk of infection.


In this article, we describe a Japanese patient with severe interstitial pneumonia probably caused by sorafenib treatment for metastatic renal cell carcinoma.


To our knowledge, this is the first case report that demonstrates the occurrence of fever with low-dose amifostine therapy without the manifestation of accompanying rash or hypotension.


DISCUSSION: After exclusion of other causes, the onset of thrombocytopenia after administration of lansoprazole, the resolution of the adverse reaction after discontinuation of the drug, and the fact that no other medicines were introduced during this time frame lead us to believe that this was most likely an idiosyncratic thrombocytopenic response to lansoprazole.


The combination of GM-CSF to accelerate hematological recovery and the possibility of administering large doses of a liposomal form of Amphotericin B were the contributing factors to the resolution of the infection.


By continuous irrigation it is frequently used to treat suppurative mediastinitis after median sternotomy.


Multidrug-resistant, progressive, invasive diffuse spinal aspergillosis: case report and review of the literature.


Complete disappearance of the primary tumor and involved inguinal lymph nodes was achieved with three courses of the cis-platinum-containing chemotherapy regimen BMP administered prior to radiotherapy.


We report a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin and developed a peculiar dermnatitis in the irradiated field after being exposed to subsequent chemotherapy with oxaliplatin.


This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue.


A review of the current literature was undertaken to examine the effects of antidiabetic agents on cardiovascular disease, and with the help of illustrative patient case examples, useful information is provided for clinicians to individualize therapy for patients with type 2 diabetes.


Acute myeloid leukemia and lung cancer occurring in a chronic lymphocytic leukemia patient treated with fludarabine and autologous peripheral blood stem-cell transplantation.


Although combinations of belladonna, ergotamine, and phenobarbital have been used for medical treatment of menopausal symptoms since the 1960s, this is the first known case report of its association with anticonvulsant hypersensitivity syndrome.


Since both hypothyroidism and iron deficiency anemia may coexist, additional thyroid function testing is recommended in patients treated concurrently with ferrous sulfate and L-thyroxine.


His treatment was initiated with tacrolimus (dose of 0.15 mg/kg/day) in two divided doses along with prednisolone 60 mg/m(2)/daily.


We present a pediatric patient with leukemia and a severe, L-asparaginase-induced necrotizing pancreatitis, treated successfully with percutaneous drainage used to flush the infected necrotic parts.


Administration of excessive insulin induced hypoglycemia within 4 to 8 hours, followed by rebound hyperglycemia.


Differences were found in the categories of seriousness and outcome of the reported ADRs between patients and healthcare professionals.


Pediatric neurosurgeons commonly instill vancomycin into the ventricles to treat shunt infections.


Cardiac time intervals of a fetus in labor can be presented, which did not change significantly throughout the first stage of labor.


Five patients showed grade 3 and 4 adverse reactions, all hematological.


The risk factors for this presentation remain undefined.


Twenty-nine patients with gynaecological cancers who received over 400 mg of doxorubicin were monitored electrocardiographically to determine whether cardiac glycosides countered the adverse effects of high total doses of doxorubicin.


Children who are treated with topiramate should have a careful history taken preoperatively looking for signs of a metabolic acidosis and baseline blood chemistries should be measured prior to surgery to detect an asymptomatic metabolic acidosis.


The following data set was acquired: the type of caustic agent, the time of the burns, the delay and type of immediate treatment and the time and type of first aid, the subsequent medication, the clinical grading and the later results.


Leakage from a conjunctival break created during trabeculectomy may cause serious complications such as shallow anterior chamber, hypotony, and a flat bleb in the early postoperative period.


We report a case of SJS in a 14-year-old male with nephrotic syndrome, who was treated with oral prednisolone for 6 weeks.


METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.


Lichenoid drug eruption to salsalate.


We present the first case (to our knowledge) of a potentially serious drug-drug interaction between zafirlukast and theophylline.


However, other factors or drugs (e.g. cresol) are thought to induce MH.


METHODS: A 40-year-old female with a 3-year history of panic disorder was prescribed fluvoxamine 50 mg day(-1) in addition to clorazepate dipotassium and sulpiride.


The treatment for acidosis and hyperkalaemia should be started as soon as RTA is diagnosed, and the dosage of FK506 should also be reduced if possible.


CASE HISTORY: A 58-year-old male Caucasian developed delayed onset diffuse lamellar keratitis, seemingly in the absence of an epithelial defect, 25 days following an enhancement LASIK procedure to his right eye.


Hypernatraemia induced by sodium polystyrene sulphonate (Kayexalate) in two extremely low birth weight newborns.


We present a case of antisynthetase syndrome whose predominant feature was fibrosing alveolitis and which may have been drug-induced.


Despite the withdrawal of ampicillin and aggressive systemic and wound care, the infant died.


However, they subsequently were shown to be associated with propranolol.


It has become key to treating attention deficit-hyperactivity disorder (ADHD) in children and adolescents.


Long-term treatment with high-dose corticosteroids exposes patients to potentially serious adverse effects.


The severity of uremia in patient 2 could be one of the conditions that, in association with the abrupt changes obtained with IVPMP, predispose to neurological manifestations.


HUS has been reported after several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens.


The case of a bipolar patient who developed thyrotoxicosis with severe exophthalmos while on lithium therapy is described.


MR of the brain was performed in eight patients (mean age, 14.9 years) with osteogenic sarcoma during or after IV treatment with high-dose methotrexate.


Portopulmonary hypertension recurred when the transplanted liver failed and again resolved after a second liver transplantation.


However, 1 eye had vitreous hemorrhage after repeated injections of tPA.


A 52-year-old woman was seen in our outpatient clinic for pain and numbness in the left lower lip and chin, which developed following an endodontic treatment for her mandibular left second premolar.


Ototoxicity as a result of cis-platinum administration is well documented.


The following is a case report analysis intended to draw attention to the need for better care coordination by describing the observed relationship of olanzapine to metabolic changes manifested as uncontrolled diabetes mellitus and weight gain.


There is a possible association between eosinophilia and myocarditis, a life-threatening condition.


We present a unique case of a patient, without any prior history of a movement disorder, who developed tics following a single dose of atomoxetine that did not improve until interventional therapy was initiated.


The study was approved by the McGill University Health Centre Research Ethics Board.


Three of the four airmen experienced undesirable HbA1c levels.


The use of sodium thiosulfate seemed to be a reasonable nonspecific therapeutic approach for the management of TC in this case.


The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.


On day 13, a 24-hour urine collection had a protein excretion of 3151 mg.


In our case, the seeding might have been related to the type of needle used and the multiple passes required to treat the liver lesion.


Although numbness of the left arm was not improved, her overall pain score was reduced by 2 on the 7th day after the start of SKT.


We are unaware of any previous cases of statin-mediated unmasking of RMD.


Dalteparin, an LMWH, was started at a maximum dose of 18,000 units subcutaneously once daily, according to British national prescribing guidelines.


Basal and secretin-stimulated gastrin responses were suppressed but not normalized.


PURPOSE Perivascular epithelioid cell tumors (PEComas) represent a family of mesenchymal neoplasms, mechanistically linked through activation of the mTOR signaling pathway.


Recurrent bacteremia by Chryseobacterium indologenes in an oncology patient with a totally implanted intravascular device.


Just after the initiation of the partial CPB, high inspiratory airway pressure was suddenly recognized.


One suspicious mechanism is the low content of calcium ion stabilizing proteins such as hyaluronate or fetuin in treatments for severe eye burns.


CSA was withdrawn, and a new MRI was normal after 2 months.


Development of pemphigus herpetiformis in a patient with psoriasis receiving UV-light treatment.


The patient was treated with oral prednisolone 70 mg/day on a tapering schedule.


Effects of esomeprazole on the pharmacokinetics of atazanavir and fosamprenavir in a patient with human immunodeficiency virus infection.


The connective tissue disease was characterized by an erythematous rash, hair loss, nephritis, splenomegaly, seizures, and coma.


There was no evidence of residual basal cell carcinoma.


Atrial fibrillation following methylprednisolone pulse therapy.


In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.


These cases suggest the possibility that, in some patients, leukopenia or agranulocytosis during olanzapine treatment might be dose-related.


Although the manifestations are the same as those usually associated with the use of vincristine, in these cases the severity appears remarkable.


We describe the current data on sorafenib and challenges faced in patients with HCC.


FK506, which began to be administered 12 days earlier, rose to a level of 44 ng/mL (normal range, 10-20 ng/mL) 1 day before neurologic abnormalities began.


Two days after administration of Kalimate enema, he had profuse hematochezia, and a sigmoidoscopy showed diffuse colonic mucosal necrosis in the rectum and sigmoid colon.


Around 1990, psychologists and educators began to notice increasing use of methylphenidate by students.


A small initial dose of prazosin ranging from 0.5 to 1 mg has been recommended to avoid the first-dose phenomenon characterized by a sudden and severe drop in blood pressure after the administration of the first dose of prazosin.


Monitoring DPD activity may be important in the management of patients experiencing severe toxicity secondary to FUra chemotherapy.


A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.


For treatment of this condition he was given androgens and corticosteroids.


Furthermore, a chest CT scan in case 1 and an arteriography in case 2 confirmed the PTE-related hypoperfusion.


The patient was started on intravenous calcium gluconate.


There were some temporal periods of good tolerance between these episodes.


The patient then became psychotic again and has since experienced periodic phases similar to the previous illness.


The antiviral effect of lamivudine was fair, and no objective side effect was experienced during the transplant procedure.


Four weeks earlier she had developed hepatopathy during a regimen of carbamazepine, lynestrenol and sodium valproate.


Cutaneous side effects, namely acneiform eruption, xerosis, telangiectasia, hyperpigmentation, fissures, hair and nail changes, are reported in literature.


A twelve year-old-girl with idiopathic partial epilepsy with secondary generalization, developed acute psychosis 10 days after the administration of levetiracetam.


The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy.


Recently, many cooperative groups use dexamethasone instead of prednisone during induction.


Many drugs, especially antibiotics, can produce this untoward effect.


The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease.


All three had been diagnosed earlier with epilepsy, and their electroencephalogram (EEG) findings were abnormal.


One year later, decreased fluency and mild ataxia persists.


The patient was admitted to the hospital for exacerbation of heart failure.


OBJECTIVE: To report four patients with antinuclear antibody-positive migratory arthralgias and acute inflammation unrelated to the underlying inflammatory bowel disease, fulfilling the criteria of a drug-induced lupus-like syndrome.


This case report demonstrates the lack of adverse events in a pediatric patient administered nesiritide beyond the recommended dosing parameters.


This case is unique because of the measurement of olanzapine in brain tissue obtained from seven regions in addition to the commonly collected biologic matrices.


This therapy was also complicated by Warfarin-induced skin necrosis.


Therapy with ATG should be considered in childhood severe aplastic anemia when bone marrow transplantation is not possible.


Even after a strict warning, he took another quinine tablet that evening, which triggered his fifth episode of severe thrombocytopenia, and confirmed the etiology of quinine-induced thrombocytopenia.


The patient was discharged on oral methylprednisolone and has not had recurrence of the skin lesions.


OBJECTIVE: To report two cases of fixed drug eruption induced by methylphenidate.


Treatment with methotrexate and prednisone.


The relation between tacrolimus treatment and staining was suggested by the appearance of pigmentation during topical tacrolimus treatment and its clinical disappearance when treatment was stopped.


Toxoplasma polymyositis was diagnosed in a dog given repeated injections of glucocorticoids for a skin condition.


She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.


A rare adverse effect is a localized lipoatrophy at the site of injection, which has previously been observed and described in 11 patients.


Fever and maculopapular rashes appeared at 10 days after phenytoin initiation, and then the drug was discontinued.


Severe rash, including the Stevens-Johnson syndrome (SJS), is the major toxicity of nevirapine and is described in the package labeling with a prominent, boxed warning.


Possible side effects of tPA injection, such as increased intraocular pressure and corneal edema, were not observed.


Two lines were inserted by a cut-down technique into the external jugular and one line by the percutaneous technique into the subclavian vein.


Methicillin-resistant Staphylococcus aureus osteomyelitis of the scaphoid from a catheter in the radial artery.


In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.


Evaluation at another laboratory showed normal levels of TSH, raising the possibility of interfering substances.


We discuss the possible common immunological basis for these two diseases and the risks and benefits of immunosuppressive therapy.


The symptoms arose within 3-5 min after immersion in water, as a white sponge-like appearance, and resolved after a variable drying period.


Cell-mediated immune reactions mediated by OKT8+T cells might have caused the leukopenia, although other mechanisms involving cytotoxic antibodies or antibody-dependent cell-mediated cytotoxicity cannot be excluded.


BACKGROUND: Previous studies indicate that photodynamic therapy provides effective relief from biliary obstruction in advanced cholangiocarcinoma.


All-trans retinoic acid has revolutionized the treatment of acute promyelocytic leukemia, but this therapy is often complicated by the all-trans retinoic acid syndrome.


Administration of infliximab and adalimumab gave excellent clinical response but was discontinued due to adverse events.


The patient's diabetic misconceptions remained, but he appeared to gain sufficient insight to prevent recurrent hypoglycaemia.


The most common symptoms are fever (78%), abdominal pain (92%), and cloudy dialysate (90%); 76% of cases had a predominance of polymorphonuclear cells in peritoneal fluid.


We believe that total cyclosporine withdrawal is feasible, but strongly recommend overlapping mycophenolate mofetil treatment with cyclosporine.


In view of the close time association between the start of chemotherapy and the acute onset of massive embolism other explanations, such as spontaneous necrosis, must be considered less likely.


Although clonazepam therapy is not new, it appears to have been omitted from current pain texts and journals as a treatment option for phantom limb pain.


After analysis of the case, ruling out other possibilities and using the Naranjo probability scale, we found that there is a highly probable likelihood that the symptoms presented by our patient were secondary to his drug therapy.


While she was receiving the maximum dose of 180 mg/day of cinacalcet HCl and PTH at 443 pg/mL, she needed to be hospitalized for a right hip prothesis.


After taking the first tablet, she developed dyspnea, cough, and wheezing.


PATIENT: A 46-yr-old female with ventilator-dependent, proliferative-phase acute respiratory distress syndrome complicated by Pseudomonas aeruginosa bacteremia and sepsis.


CONCLUSIONS: We have seen an increased incidence of acute INH neurotoxicity because of the resurgence of TB in New York City.


Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with propylthiouracil therapy.


Moreover, the presented cases serve as a link in a spectrum of hepatic disorders recently recognised to be caused by environmental agents such as vinyl chloride, arsenic, and thorotrast, and by contraceptive and anabolic steroids.


INTERVENTION: A 50-year-old female with bilateral canalicular obstruction secondary to docetaxel therapy received botulinum toxin injections (5 units each) into the lacrimal glands of both eyes.


The patient was positive for antibody against complexes of heparin and platelet factor 4, and was diagnosed as heparin-induced thrombocytopenia with thrombosis syndrome (HITTS).


Serial electrocardiograms revealed a minimally and asymptomatically prolonged QT interval.


BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.


The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma.


The case of a bipolar patient who developed thyrotoxicosis with severe exophthalmos while on lithium therapy is described.


Drug provocation test is important in this case to confirm which drug had caused hypersensitivity reaction because anti tuberculosis drugs were the treatment of choice for her illness.


Resolution of the symptoms was observed in both patients when interferon alpha was withdrawn.


Rebound hyperglycemia following overdosing of insulin in cats with diabetes mellitus.


We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.


An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.


INTRODUCTION: Despite high success rates with free-tissue transfer, flap loss continues to be a devastating event.


While the combination of daily oral steroids and daily oral cyclophosphamide dramatically improves the outcome of WG, this therapy is not without serious side effects.


Anhedonic ejaculation with desipramine.


Cutaneous adverse effects during therapy with an epidermal growth factor receptor (EGFR) inhibitor.


We report a case of an infant with complex congenital heart disease who was placed on captopril for afterload reduction following cardiac surgery and subsequently developed pulmonary infiltrates with eosinophilia.


Electrocardiogram (ECG) on arrival and at 3 hours showed no acute changes; cardiac enzymes revealed minimal MB elevation.


Most clinicians are routinely exposed to irritants such as latex, detergents, and chemicals.


None of these patients experienced a relapse of their PTLD with follow-up ranging from 1.5 to 5 years.


We describe a 14-year-old bone marrow transplant recipient who was anti-HBs-positive before the procedure and afterwards developed acute infection with hepatitis B virus (HBV).


Inadvertent substitution of acetohexamide for acetozolamide.


Methylphenidate-associated enuresis in attention deficit hyperactivity disorder.


Caution is advised in administering arginine to patients with renal or hepatic insufficiency, or both.


After recovery, in an attempt to provide adequate calories and to elucidate the inciting agent, he was rechallenged with his original total parenteral nutritional solution which contained 500 ml/day of a 20% fat emulsion.


Ideally, a urethral bulking agent should be non-immunogenic and biocompatible, leading to minimal inflammatory and fibrotic response.


Rhabdomyolysis in patients with acute lymphoblastic leukemia.


METHODS: We report a patient who had an anaphylactic reaction during the intravenous infusion of cyclosporine.


We describe in detail the first U.S. case report, of a 4(1/2)-year-old boy who experienced angioedema during treatment with oxcarbazepine.


Reports of this phenomenon in animals are reviewed.


Adding Dantrolene and Oxybutynin elevated the blood level of Carbamazepine, possibly by inhibition of cytochrome P450.


A 63-year-old man presented with an 11-month history of progressive myoclonus in the right abdominal wall.