Hydroxyurea and sodium phenylbutyrate therapy in thalassemia intermedia.


A patient with a 30% scald burn was treated with topical silver sulfadiazine (Silvadene).


RESULTS: There is no reliable and effective treatment of anterior ischemic optic neuropathy.


Primary osteogenic sarcoma of the skull.


RESULTS: A well-documented case report involving tap (draft) beer consumed while on an MAOI supports an earlier study, which recommended that all tap beers be restricted on MAOI diets.


Reactivation of human herpesvirus-6 (HHV-6) is frequently observed, although the cause of DIHS is still unknown.


Histologic examination showed in both cases epithelioid granulomas in close relation with scattered pigment.


She developed a pre-engraftment immune reaction, which responded well to prednisolone, and engraftment was documented.


Tc-99m labelled Anti CD 66 monoclonal antibody imaging is a useful, noninvasive approach to the assessment of bone marrow reserve under such circumstances.


In addition to antimicrobial therapy, treatment usually involves craniotomy and excision of the abscess.


Positive CSF PCR of JC virus confirmed the diagnosis.


DISCUSSION: Amphotericin B deoxycholate has been reported to produce significant cardiac toxicity, with ventricular arrhythmias and bradycardia reported in overdoses in children and in adults with preexisting cardiac disease, even when administered in conventional dosages and infusion rates.


Our literature review revealed an additional six cases of onset of inflammatory arthritis in MS patients receiving IFN-beta.


Rare instances of autoimmune conditions have been observed in association with its use.


The drug was identified and quantitated in plasma and urine using an HPLC technique with diode-array detection.


On discontinuation of the drug, serum CK concentrations returned to normal within eight days.


Hycanthone is an antischistosomal drug with promising antitumor activity against experimental animal tumors.


The multiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin.


Over 20 years, 877 patients with Crohn's disease, 492 women (56.1%) and 385 men (43.9%), were evaluated with patient follow-up data available for a mean of 7.8 years.


History revealed that the patient had taken a combination phenolphthalein/docusate sodium (Correctol) over-the-counter laxative 1 day prior to admission.


Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.


Severe systemic hypersensitivity reaction to ibuprofen occurring after prolonged therapy.


Unexpectedly, liver function returned to normal on stopping the drug.


Paraspinal muscle impingement causing acute Brown-Sequard syndrome after posterior cervical decompression.


Administration of low-dose cidofovir was associated with clearance of BK virus DNA from blood and allograft, and stabilization of renal function in both patients, without significant toxicity.


After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.


Nephrotic range proteinuria gradually regressed after stoppage of local injection of IFN-beta without glucocorticoid treatment.


Two cases of candidiasis occured in the stomach.


Initial treatment for MN consisted in corticosteroids and immunosuppressors (ciclosporin, mycophenolate mofetil, rituximab, chlorambucil) in all patients.


Findings of electrophysiologic study and cardiac magnetic resonance imaging were within normal limits, pointing to the ingestion of Aconitum as the most likely source of his arrhythmia.


Two complications were identified (0.1%), one at each institution.


The authors have encountered this entity in two patients who were deemed disease-free following combination chemotherapy for malignant disease.


Molluscum contagiosum is a common viral skin infection in children with atopic diathesis and not rare in HIV patients.


An encephalopathy and cardiomyopathy developed in a seventeen-year-old girl with chemotherapy-induced renal failure while receiving an intravesical aluminum infusion for hemorrhagic cystitis.


In each case, 25-100 micrograms of intracoronary nitroglycerin promptly (30-45 seconds) resulted in reopacification of the vessel involved in spasm and resolution of evidence for ischemia.


OBJECTIVE: To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl.


No relationship was identified between the extent and the severity of the skin lesions with the phenytoin and radiation dosages and with the histologic type and origin of the intracranial malignancy.


The patient expired after seven cycles of treatment had been completed because of pulmonary fibrosis and the drug toxicity of bleomycin.


Treatment strategies involved use of antimicrobials and supporting the damaged multi-organs.


Many types of skin disorders concomitantly occur with hepatitis C virus infection.


After 8 months of administration of human insulin by a jet injector, there were no more new lesions of lipoatrophy and those affected areas were substantially ameliorated.


Stenotrophomonas maltophilia (previously named Xanthomonas maltophilia) is an aerobic, nonfermentive, Gram-negative bacillus that is widespread in the environment.


With the recent Women's Health Initiative Study demonstrating increased risk of breast cancer and cardiovascular events associated with hormone therapy, many women may resort to herbal remedies for persistent menopause symptoms.


Macrophage activation syndrome in systemic juvenile rheumatoid arthritis successfully treated with cyclosporine.


A forty-two year old female with known alcoholic liver disease was given intravenous lorazepam and diazepam for delirium tremens.


These patients often experience acute intradialytic manifestations while non-pharmacologic interventions as pharmacologic agents are sometimes insufficient to improve symptoms.


It is recommended that daily leukocyte counts be done in burn patients being treated with silver sulfadiazine.


We report a case of a young woman with SLE and thrombocytopenia, who developed severe perspiration, headache, and seizure after receiving cyclosporine.


We report the first case of doxycycline-induced hypoglycemia in a young nondiabetic man.


Complete relief of pain was noted in 73% of patients during the treatment.


CONCLUSION: This case and the results of the analyses are in accordance with the described problems and results published earlier.


Pancreatitis has been associated with the tetracycline class of antibiotics and concerns about tigecycline-induced acute pancreatitis have recently been raised.


BACKGROUND: Pemphigus is an autoimmune blistering disease of the skin and mucous membranes.


All three patients had rheumatoid arthritis and had received chloroquine for between 12 and 18 months with a maximum dose of 250 mg/daily.


After cessation of the sulfasalazine and completion of a six-week course of corticosteroids, these problems resolved over a period of four to six months.


Retrospectively, bucillamine was believed to be the cause of the giant hypertrophy because of its structural similarity to D-penicillamine, which was the subject of an abundance of reports of mammary hyperplasia.


Case Report: We report a case of methanol poisoning exhibiting complete recovery from severe visual impairment following treatment with ethanol, fomepizole, and hemodialysis.


Viscoelastic material as an adjunct to dissections and to treat microperforations during nonpenetrating filtering surgery.


The characteristics of the small subgroup of chronic anorexics, in whom the risk/benefit ratio may justify such a regime, are tentatively outlined.


In addition, 1 of these biopsy specimens also had scattered single eosinophils, unlike autoimmune hepatitis.


This article focuses on the methodological issues involved in choosing instruments to monitor behavior, once a comprehensive evaluation has suggested trials on Ritalin.


Sustained ventricular tachycardia in a thalidomide-treated patient with primary plasma-cell leukemia.


In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.


We report marked QT prolongation and torsades de pointes in a setting of flash pulmonary edema resulting from acute myocardial ischemia in a patient who was being treated with dofetilide for atrial fibrillation.


We believe that immunosuppression-induced pneumonitis in a lung allograft is a serious dilemma for lung transplant physicians


Echocardiogram showed normal left ventricular systolic function with mild mitral and tricuspid regurgitation and trace aortic insufficiency.


Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.


The infant was given indomethacin to induce constriction of sPDA.


The deletion results in decreased CYP2D6 activity, possibly leading to drug accumulation.


BACKGROUND: This is the first communication of a fatal spontaneous spinal epidural hematoma following thrombolysis.


Concentrated topical epinephrine is safe in endoscopic sinus surgery.


A case of necrotizing fasciitis of the vulva arising in a leukemic patient during a chemotherapy nadir is presented.


The third patient had been suffering from serious akathisia while on risperidone, and was cured after switching to olanzapine, but thereafter the patient suffered from RLS at nighttime.


Tics and Tourette syndrome are common comorbidities of patients diagnosed with attention-deficit/hyperactivity disorder (ADHD).


Laboratory determinations were used to directly evaluate therapeutic anticoagulant effects, and dosage regimens were adjusted to achieve desired anticoagulant levels.


The pathogenetic mechanism of these symptoms might possibly be explained as potentiation of the action of the neuroleptica by oral antidiabetics.


Life-threatening interstitial lung disease associated with trastuzumab: case report.


Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or "cutting" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.


The association of venlafaxine treatment with ischaemic events could be explained by its unique pharmacological and haemodynamic properties.


A 56-year-old Caucasian man who received concomitant chemotherapy and radiation for head and neck cancer developed fever concurrent with the administration of amifostine.


Radiologic recognition of adriamycin cardiotoxicity.


The lesions resolved after treatment with topical steroids and also oral allopurinol in one of the cases.


The variation among different diagnostic criteria makes this syndrome a challenging diagnosis at times, in particular when atypical antipsychotics are suspected as the causative agent.


Therefore, wide spectrum antibiotics were continued.


Monitoring of liver function tests should be mandatory in patients receiving high doses of cyproterone acetate; the drug should be withdrawn immediately if abnormal liver function tests are found.


The cause of hiccups should be expressly stated for treatment.


Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2 1/2 months of treatment with penicillamine.


Spinal cord infarction during use of zolmitriptan: a case report.


Few studies have been carried out regarding preoperative chemotherapy utilized in the treatment of primitive neuroectodermal tumors/medulloblastomas (PNET/MB).


Multifocal osteomyelitis caused by Candida dubliniensis.


We describe the clinical course of these patients and their management aimed at maximizing the effectiveness of gold therapy.


Early onset of hemophagocytic syndrome following allogeneic bone marrow transplantation.


The development of perianal fistulas in 2 patients, granuloma on biopsy in 1 patient and perianal skin tag in 1 patient, led to a diagnosis change of CD.


Aminoglycoside-associated hypomagnesaemia in children with cystic fibrosis.


Localized purpura associated with lamotrigine.


All symptoms disappeared soon after stopping the drugs, though in two cases the papilloedema persisted for many months.


The mean histologic activity index scores for patients in groups 1 and 2, respectively, were 6.7 and 5.4.


Several cases of lithium-induced Creutzfeldt-Jakob syndrome have been reported to date; all of them were elderly patients and a half had "therapeutic" lithium serum levels.


The absence of borderline mutations in the normal population, and the co-segregation of the expanded allele with neurological signs in one kindred suggest that SCA2 mutations may be responsible for a subset of familial parkinsonism.


Laboratory evaluation ruled out the most common causes of fulminant hepatitis.


Transient leucopenia and thrombocytopenia associated with sodium nitroprusside infusion.


Voriconazole (VRC) has not previously been reported to cause angio-oedema.


The risk is probably higher with valproic acid than carbamazepine.


Although uncommon, exogenous lipoid pneumonia (ELP) should be considered when patients present with this symptom complex.


Drug-induced interstitial nephritis in a child with idiopathic nephrotic syndrome.


The reported effects of these agents in increasing total Hb, however, have been inconsistent and there have been no studies on the combination of these medications.


They had not been transfusion-dependent prior to treatment.


The occurrence of neuromuscular blockade and the resulting potentiation of muscle relaxants during magnesium sulfate (MgSO4) administration is well known.


The patient had required two surgical decompressions of the right orbit to relieve pressure, which occurred secondary to progression of the exophthalmos, and was scheduled for further surgery.


Intravenous epoprostenol was administered perioperatively to control the pulmonary hypertension in both instances.


Dermatomyositis, complicated with pneumomediastinum, successfully treated with cyclosporine A: a case report and review of literature.


Repeated blood transfusions were associated with rapidly evolving renal failure coupled with anemia and thrombocytopenia.


How safe is our blood transfusion?


The pathogenesis of autoimmune hepatitis entails complex interactions between triggering factors, autoantigens, genetic predisposition, and immunoregulatory networks.


Dose-intensive melphalan with blood stem cell support for the treatment of AL amyloidosis: one-year follow-up in five patients.


Case report.


We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.


This case and other published evidence should alert physicians to the possibility of fatal erlotinib-induced ILD.


Acute hemorrhagic gastritis associated with acetazolamide intoxication in a patient with chronic renal failure.


Two patients received corticosteroids as well as parenteral nutrition during the course of their disease.


Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.


However, five patients showed delayed 30-Hz flicker b waves, and seven patients showed delayed oscillatory potentials.


Treatment with oral 25-hydroxyvitamin D3, 50 microgram daily, produced marked biochemical, radiological, and histological improvement after 6 months.


Early postsplenectomy arthritis caused by penicillin-resistant Streptococcus pneumoniae.


He had a history of treatment-resistant chronic schizophrenia.


A 55-year-old woman received 2 cycles of therapy with cisplatin 100 mg/m2 without difficulty.


If this patient would have died suddenly without the laboratory investigations that lead to the diagnosis of myeloblastic leukemia, the cause would have been probably and wrongfully allotted to treatment with olanzapine.


Both patients had laboratory-proven subtherapeutic anticonvulsant serum levels.


The patient was transferred to a rehabilitation center.


10 and 15 exchanges of PD using an automated cycler were respectively performed during the first and second 24-hour periods after gadolinium exposure.


She received no other concomitant medications.


A case report with emphasis on medication and management.


The first patient's KI67 level was 2.5% and was positive for the progesterone and estrogen receptor.


Their hair grew back after 2-3 months steroid therapy.


Infection and thromboembolic events are relatively frequent complications, but aneurysm formation is rare.


Sciatic nerve compression very rarely occurs bilaterally.


Instead of diverse antiretroviral therapies, the viral load was increased.


All three patients likely experienced electromechanical dissociation (EMD).


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


D-penicillamine induced crescentic glomerulonephritis: report and review of the literature.


An 18-year-old man with attention-deficit-hyperactivity disorder (ADHD) was prescribed varenicline for smoking cessation.


Thrombotic thrombocytopenic purpura induced by trimethoprim-sulfamethoxazole in a Jehovah's Witness.


Recently, some studies have also reported association between patients with juvenile rheumatoid arthritis (JRA) treated with Methotrexate (MTX) and malignant lymphoma developing.


METHODS: Between 1990 and 2003, 218 patients underwent an all-polymethylmethacrylate, collar button-shaped KPro surgery.


Patients with a history of previous coronary artery disease or risk factors for coronary artery disease should be observed closely for signs of myocardial ischemia, particularly during the initial infusion.


Possible causal mechanisms are discussed.


RESULTS: Nine patients were cured, one patient with poor adherence to treatment and advanced AIDS died.


Serious lead poisoning in childhood: still a problem after a century.


BACKGROUND: Colchicine has a known adverse effect on wound healing through its inhibitory effect on tubulin-dependent cell functions and through collagenase activation.


No dose-rate effect has been reported, however.


Other toxicities were generally mild.


The aim of this study was to determine the usefulness of skin tests in ruling out cross-reaction to cisplatin to continue platinum-based chemotherapy in patients who are responsive to these agents.


One month later the patient remained symptom-free.


Histochemistry identified a calcium containing melanin-like substance.


Corynebacterium striatum has rarely been reported to be a pathogen, causing pleuropulmonary infections and bacteremia in only immunocompromised or anatomically altered patients.


However, all Brown Norway rats that received estradiol treatment developed pyometra, whereas none the Sprague Dawley or control Brown Norway rats did.


Necrotizing fasciitis secondary to bisphosphonate-induced osteonecrosis of the jaw.


While more studies are needed to better understand the mechanism of action after suspending HAART, the complete resolution of the signs and symptoms was observed.


Seven psychiatric inpatients receiving carbamazepine 600 mg/day were coadministered clarithromycin 400 mg/day for 5 days to treat atypical pneumonia.


A mosaic karyotype with XY and XO was found on chromosomal analysis and gonadectomy was performed in view of the high risk of gonadoblastoma.


Super potent topical corticosteroid use associated with adrenal suppression: clinical considerations.


On hospital day 2 his platelet count dropped to 47,000/microl and bottomed out at 36,000/microl by day 3 with other blood cell counts remaining within normal limits.


We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.


Chronic postoperative bacterial endophthalmitis has recently assumed a prominent role in differential diagnosis of inflammation following extracapsular cataract extraction with posterior chamber intraocular lens implantation.


METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.


Additionally, ceftriaxone may cause problems in either adults or children with preexisting disease, who may not be well-nourished, or who may be dehydrated.


Severe heparin associated thrombocytopenia is a rare complication of heparin therapy.


C1-inhibitor deficiency, or hereditary angioedema, is a genetic disorder characterized by recurrent circumscribed, nonpruritic, nonpitting subepithelial edema.


A severe form of exophthalmos resulting from lithium therapy has not been described in the literature.


Ampicillin-associated seizures.


Differentiation between recurrent tumor and radiation necrosis in a child with anaplastic ependymoma after chemotherapy and radiation therapy.


Analysis of the pharmacokinetic data suggests that haemodialysis or haemofiltration would be more efficacious for removal of the drug, and these treatments should be performed if available.


Two inactive patients received no corticosteroids before or after the diagnosis of pancreatitis.


Even with the low dose of neuraxial drugs commonly administered in combined spinal-epidural labor analgesia, this case underscores the importance of vigilance, frequent monitoring, proper positioning, and rapid resuscitation with escalating doses of ephedrine, atropine, and epinephrine, all of which are essential in the presence of bradycardia or asystole in these patients.


The case report of the corticosteroid complication in an eight-year-old girl with immune thrombocytopenic purpura is presented.


A 17-year-old boy with acute lymphoblastic leukemia developed acute renal failure within 48 h of an intravenous high-dose methotrexate (5 g/m2) infusion.


After a seizure-free period of 3 months the patient died from hepatic failure resembling Reye syndrome.


Intranasal desmopressin provides symptomatic relief with few serious complications.


The cost of care for the enterally supported child was less than one third of the TPN-supported child.


We believe that this is the first report of secretory carcinoma of the endometrium associated with tamoxifen use.


CONCLUSIONS: TNF-alpha inhibitors in general should be used cautiously in chronic hepatitis B viral infection.


The patient was treated with radiofrequency cautery and is now asymptomatic.


A patient developed transient, acute myopia while on isotretinoin (Accutane) therapy for acne.


Combination of sodium thiosulphate, cinacalcet, and paricalcitol in the treatment of calciphylaxis with hyperparathyroidism.


Pure red cell aplasia due to parvovirus B19 infection after liver transplantation: a case report and review of the literature.


As a result, there have been several reports of children and adults on TPN who have developed WE as a result of thiamine deficiency.


A mentally retarded 23-year-old woman with myoclonic astatic epilepsy developed an abnormal posture of extreme forward flexion, called camptocormia, during valproate monotherapy.


The liver had zolpidem present at a concentration of 4.74 microg/g, and the gastric contents had a total of 172 mg zolpidem.


One patient died with myeloid leukemia at 43.5 months after initial treatment.


It also produces weak beta- and calcium-channel blockade.


Disseminated superficial porokeratosis and immunosuppression.


A 61-year-old man with early diffuse cutaneous scleroderma with myositis and progressive interstitial pneumonia developed generalized erythema with high fever 3 weeks after taking sulfamethoxazole/trimethoprim.


Suramin has demonstrated modest activity against prostate cancer and is being investigated in clinical trials.


A MEDLINE search identified all the reported cases of hypersensitivity reactions to cyclosporine.


Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction.


However, he developed acute renal failure, hyperkalemia, and hyperuricemia 30 d after receiving the sorafenib treatment.


This case and a review of the literature show the severe and unpredictable nature of ethambutol toxicity and its potential for irreversible vision loss despite careful ophthalmologic monitoring.


All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis.


We describe children and adolescents with chronic hematologic and oncologic diseases who exhibited drug-seeking behavior or anticholinergic symptoms with the use of diphenhydramine.


Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine.


Cutaneous alternariosis is an opportunistic infection.


A 72-year-old woman was treated daily with two solutions including Tathion eye drops for senile cataract for two years and three months.


Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.


Therapeutic effect of intradermal injections with difucosyl lactosamine (dimeric Lex) on patients with rheumatoid arthritis.


Ultrasound study revealed enlarged kidneys with increased echogenity and loss of corticomedullary differentiation.


The development of erythroid leukemia plus carcinoma in these two men suggests mutagenic change secondary to cyclophosphamide therapy.


Common adverse reactions of immunosuppressive treatment are infections, hematologic and liver function abnormalities, but neurologic complications may also be seen.


The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.


Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.


To keep the artery patent, i.c. streptokinase had to be continued until emergency bypass surgery was performed.


METHODS: A retrospective review of patients originally diagnosed with ulcerative colitis, status post colectomy and IPAA, who developed findings compatible with Crohn's disease was undertaken.


Although conventional MRI correlates have been described for this stroke-like syndrome, DWI data are largely unavailable.


Rituximab is a chimeric anti-CD20 monoclonal antibody.


Amphotericin B-induced seizures in a patient with AIDS.


MATERIALS AND METHODS: Between March 1997 and December 2001 at our Department of Musculoskeletal Oncology, 231 patients with peripheral osteosarcoma received a central venous catheter to allow infusion therapy and blood sampling.


Juvenile absence epilepsy exacerbated by valproic acid.


Therefore, beta-adrenergic agents should be used with great care, especially for patients with myotonic dystrophy, because of these agents' tendency to aggravate or precipitate myotonia and to induce rhabdomyolysis.


Inclusion of specific culture media and staining protocols for mycobacteria, along with aggressive treatment on diagnosis, including lifting or amputating the LASIK flap, culturing, topical fortified clarithromycin and amikacin, while avoiding corticosteroids, may significantly improve resolution of the infection and potentially improve the visual outcome.


Compensatory hyperhidrosis: a consequence of truncal sympathectomy treated by video assisted application of botulinum toxin and reoperation.


It is unknown whether the vitamin K content or malabsorption of warfarin is the mechanism of resistance.


Three of the seven patients were given a dosage of medication and exceeding the manufacture's recommendation.


Decreased clearance of the compound has been observed in patients with renal insufficiency, and this has been associated with an increase in the ratio of morphine-6-glucuronide to morphine.


This usually occurs in patients taking other ototoxic medications, with poor renal function, or with autoimmune disease.


Iatrogenic epidural spinal abscess.


Six months later she was again prescribed sustained-release verapamil 240 mg in another clinic where the physician was unaware of her previous reaction.


The patient denied any previous medication sensitivities, and was taking oral methotrexate and prednisone at the time of emergency department admission.


DESIGN: Case series.


Most often, it is tolerated well.


The remaining lesions were treated with curette and cryotherapy.


Of 23 patients with reported outcome, 11 died within a few weeks.


Alternating sinus rhythm and intermittent sinoatrial block induced by propranolol.


We emphasise the need to be vigilant for this important but relatively rare complication, which has significant associated morbidity.


This case report presents a typical case of Sturge Weber Syndrome.


Good correlation existed between peak concentrations and AUC (r = 0.866; P less than 0.001).


Following the improvement of the symptoms of SJS, he received alternate-day oral prednisolone without any cutaneous eruption.


BACKGROUND: Animal studies have shown that some human monoclonal antibodies promote myelin repair in models of demyelinating disease.


An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.


Edema associated with ibuprofen therapy.


Rate of mitral thrombosis is 3.9% and aortic 0.25%.


Acute respiratory distress syndrome after rituximab infusion.


A 30-year-old pharmacist suffered from acute allergic contact dermatitis due to 4-chloro-7-nitrobenzofurazan (NBD-Cl).


Most cases of pancreatitis associated with L-asparaginase toxicity are self-limiting and respond favorably to nasogastric decompression and intravenous hyperalimentation.


We report a case of rhino-orbital zygomycosis caused by Rhizopus oryzae that developed in a 41-year-old male renal transplant recipient.


After only the third dose of pentamidine, it was noted that the patient's heart rate had decreased to 48 beats/minute.


We hypothesize that sibutramine, through its effect on neurotransmitters, may induce antidiuretic hormone secretion and lead to a syndrome of inappropriate antidiuretic hormone secretion.


New therapies for MDR-TB have not been introduced since the fluoroquinolones in the 1970s.


The adverse pulmonary effects of erlotinib are less well known.


We report the development of squamous-cell carcinoma within a basal-cell epithelioma that was treated with intralesional injections of 5-FU.


RESULTS: The patient developed bilateral central retinal vein occlusions in association with high-dose intravenous immunoglobulins.


The primary tumor sites included the tongue, buccal mucosa, chest wall, vagina, and clitoris.


This responded promptly to Dantrolene and Bromocriptene.


DISCUSSION: A literature search showed no reports of an interaction between warfarin and levamisole.


The longitudinal follow up DWI findings suggest reversible metabolic derangement rather than ischemia as the cause of these findings.


Five days after discontinuation of this medication his mental status returned to normal.


In contrast to infection secondary to human immunodeficiency virus (HIV), CMV colitis has not previously been described in this context.


All drugs were stopped, and the patient was transferred to another hospital for liver transplantation.


Flavimonas oryzihabitans (CDC group Ve-2) bacteraemia associated with Hickman catheters.


Unfortunately, symptoms and therefore treatment are often delayed.


Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child.


We present here the case histories of two patients who developed very severe cardiac failure at cumulative doses well below 500 mg/m2 but who survived their initial cardiac illness due to aggressive intervention.


Carbamazepine-induced tics.


The medication history is an integral part in the evaluation of a patient with hypoglycemia.


After more than 18 years after cessation of the drug, most tests showed a further deterioration, including best-corrected visual acuity (RE: 0.1; LE: 0.7).


Neither dosage nor serum levels of CBZ were in a higher range.


The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.


We report a rare case of Acanthamoeba keratitis related to cosmetic contact lenses in both eyes.


A patient is described who developed a systolic murmur soon after she was administered intravenous thrombolytic therapy for acute myocardial infarction.


Cutaneous metastatic plasmacytomas with tropism for a previously injured limb.


Pramipexole: augmentation in the treatment of depressive symptoms.


Three diabetic cases of acute dizziness due to initial administration of voglibose.


Three children presented with adrenal crises, manifested by vomiting and hypoglycaemia, after protracted courses of high-dose inhaled corticosteroids for asthma.


FINDINGS: Six children with growth retardation noted after treatment with high-dose fluticasone propionate were found to have adrenal suppression.


There were 5 outpatients who suffered chronic pain for at least 3 months.


The major limiting side effect is hemolytic anemia, which may be mitigated through careful patient selection, conservative drug dosing, close monitoring, and possibly, concurrent administration of antioxidants or cytochrome P450 inhibitors.


Vomiting occurred even with small doses of enzymes disguised in food.


Twelve days later symptoms worsened, with pulmonary edema on chest radiograph, continued weight gain, and +4 pitting edema resistant to oral diuretics.


In the second case, five cardiac arrests due to ventricular tachycardia and fibrillation occurred during several hours after beginning a trial of bretylium maintenance therapy for complex ventricular ectopy.


Immunotherapy with imiquimod 5% cream for eyelid nodular basal cell carcinoma.


Patients with sustained and nonsustained ventricular tachycardia may present the clinician with difficult management problems in the assessment of risk, decision for long-term treatment, and selection of appropriate therapy.


Administration of pyridoxine to an infant after a long period of convulsions was followed by acute hypotonia.


The same error had led to the death of her child five years earlier.


The CD4 lymphocyte count in 1991 was normal and ultrasonographic scan showed normal liver morphology.


This communication describes a patient who developed Schneiderian first-rank symptoms in the course of treatment with fluvoxamine.


Didanosine also has a potential for inducing seizures.


The patient's overall course with thiamine replacement therapy led to a complete recovery within 5 days and no sequelae were noted after 12 months.


The patients were monitored at months 1 and 3.


Four occurred in combination with MTX, one with adalimumab.


These cases suggest the possibility that, in some patients, leukopenia or agranulocytosis during olanzapine treatment might be dose-related.


Moreover, treatment with immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha can induce a condition resembling RPLS.


Magnetic resonance imaging may be useful in these cases to confirm the diagnosis of WE.


This avoids the need for bronchoscopic examination or transfer of the patient for computed tomography.


This was later confirmed by the patient.


Detection of activated eosinophils in nasal polyps of an aspirin-induced asthma patient.


AIM: To report three cases of extensive skin necrosis in cirrhotic patients treated with the vasoconstrictor agent terlipressin (Glypressin).


Easily reversible hypoxemia and hypotension induced by nimodipine.


One major concern with the use of intraperitoneal therapy is the risk of inducing peritoneal sclerosis and extensive adhesion formation.


The medical examiner's report indicated death caused by fluoxetine toxicity.


Other symptoms of drug hypersensitivity included nausea, vomiting, urticarial rash, and leukopenia.


Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy.


The use of clonidine alone and in combination to treat a variety of problems has increased in child and adolescent patients.


Flaccid quadriparesis was noted after discontinuation of vecuronium.


Although these medications are used in other conditions, we are not aware of other reports of PG exclusive to treatment for idiopathic PD.


One patient died during induction probably due to haemorrhage.


PURPOSE: To report a case of bilateral anterior uveitis associated with ovulation induction therapy using clomiphene citrate.


Because his supply of amphetamine-dextroamphetamine was diminishing, he took only half (30 mg every morning) of his prescribed dosage from days 4-12 of varenicline therapy.


Case report.


The ECG normalized in a few days after mesalazine withdrawal and the follow-up was uneventful.


The carcinomas developed after a total UVA dose of 2,042 and 1,296 joules/sq cm, respectively.


The patient remained in a depressed level of consciousness for 2 months but gradually recovered, showing a good recovery with minor subjective cognitive deficits by 6 months.


RESULTS: A 76-year-old woman developed X maltophilia endophthalmitis after cataract extraction.


Thrombolytic therapy is being used with increasing frequency to treat acute myocardial infarction (MI).


Sulfadiazine crystalluria revisited.


Disodium cromoglycate is regarded as the possible aetiological agent.


Sequential appearance of immunoblastic lymphoma and acute nonlymphocytic leukemia in a patient with angioimmunoblastic lymphadenopathy.


Allele-specific polymerase chain reaction (PCR)-based methods are now available for genotyping using leukocyte DNA.


PURPOSE: To present a case of recurrent postoperative endophthalmitis with a scleral-tunnel abscess and adjacent microbial keratitis.


It occasionally accompanies the heparin-associated thrombocytopenia and thrombosis syndrome.


Cerebral edema associated with Gliadel wafers: two case studies.


Such abuse (possibly linked to the rewarding effect of dopamine) has been recently monitored in the context of Parkinson's disease (PD) (the "dopamine dysregulation syndrome").


Restless legs syndrome due to interferon-alpha.


For one patient, thrombocytopenia due to autoantibodies to PEG-rHuMGDF developed shortly after PEG-rHuMGDF administration and persisted until chemotherapy was administered.


BACKGROUND: Diverse complications have been reported in association with the growth and medical treatment of uterine leiomyomata.


Repeat PTCA was performed 10 days postdischarge due to intraluminal stent occlusion.


The patient had several acute sinusitis and septic episodes during his acute course.


However, a cross-correlation analysis indicated that TPO responses preceded platelet responses by approximately one day in all patients.


Severe hypertension in newborn after pyeloplasty of hydronephrotic kidney.


The following day the vulvar edema had increased and spread to the sacrum.


Equine-derived antivenin was given in 14 cases (range 2-30 vials).


Case report and review of the literature.


After 46 days of treatment, radiography showed cortical hyperostosis of the long bones.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


Nitrendipine-induced gingival hyperplasia.


Classic neuroleptic malignant syndrome (NMS) was diagnosed.


In addition to our reported cases, 5 cases of nephrotic syndrome in similar patients reported elsewhere are analyzed together with our cohort.


Cardiorespiratory toxicity due to miconazole.


Heparin therapy for mistaken cardiac diagnosis in Boerhaave's syndrome.


The sub-conjunctival haematoma in a patient receiving warfarin can pose a significant management challenge.


Platelet recovery and clinical improvement coincided with administration of rituximab.


Although the efficacy of recombinant factor VIIa has been shown in many patients, concerns have arisen about the risk of thrombotic adverse events.


The usefulness of CYP2C9 genotyping before starting coumarinic treatments is discussed.


The immunoglobulin serum levels and inflammatory markers were unchanged.


Clinical features were those of a cicatricial pemphigoid, with prominent mucosal involvement leading to conjunctival and nasal scarring.


This is in contrast to similar symptoms reported by only 8 percent of a control population.


We describe the implications of these cases for the use of immunomodulatory therapy in CD and the questionable association between CD and lymphoma.


During two courses of cytostatic drug administration peak and trough plasma levels of phenytoin, carbamazepine, and valproate sodium were measured.


A moderate vitreous hemorrhage occurred four days after PDT.


METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.


This case suggests that chemotherapy with its attendant immunosuppression is a predisposing factor in the development of necrotizing fasciitis and warrants a high index of suspicion.


In a randomized trial, we compared the efficacy and toxicity of azithromycin and ceftibuten once daily in the initial (empiric) therapy of proven or suspected community-acquired respiratory tract infections (CARTI) in 163 pediatric patients: 95.5% of those treated with azithromycin and 83.6% of those treated with ceftibuten were cured or improved.


Limited documentation of this adverse effect exists in the literature.


Treatment was continued with amphotericin B colloidal dispersion, followed by fluconazole for 8 months.


Although both drugs have been reported to preserve endogenous insulin secretion and to interrupt the diabetogenic process they may be responsible for diabetes and exocrine pancreatic insufficiency in our patient.


Ankylosing spondylitis was present in two patients, but no other extraintestinal manifestations developed.


We present a case of an elderly patient with systemic lupus erythematosus diagnosed more than 40 years ago, who suffered from recurrent fractures and attendant complications despite a bone mineral density (BMD) score in the osteopenic range and treatment with bisphosphonates.


It remains to be seen whether the hepatotoxicity associated with troglitazone is a drug-class effect or specific to troglitazone.


Following steroid withdrawal and institution of gammaglobulin, the patient grew 6 inches within 2 years, regaining his vision, retrieving his stature, and normalizing his psychosocial development.


The authors describe a relation between the in vivo localized consumption of In-111 platelets and results of laboratory tests in a 82-year-old man with an aortic graft prosthesis who had chronic disseminated intravascular coagulation.


Ordinarily occurring as a commensal, Kluyvera have been reported to cause serious infections in immunosuppressed and immunocompetent hosts, causing diarrhea, urinary infections, peritonitis, and cholecystitis.


Improvements in sexual function (62%), socializing (70%), sleep (68%), and skin color (51%) were also noted.


The second organism has not previously been reported in a subphrenic abscess.


Similar symptoms developed after each challenge and resolved after discontinuing this preparation.


However, in the rare case of postoperative patch leakage, a relapse of a pseudoaneurysm may occur.


Pulmonary toxicity with mefloquine.


Acute myocardial infarction associated with systemic lupus erythematosus documented by coronary arteriograms.


Six days after she received a prescription for a 5-day course of azithromycin, her INR was 15.16.


Exacerbations of the heart failure were temporally related to the administration of the antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559).


He had a history of hypertension and uremia.


Pulmonary fibrosis associated with nabumetone.


RESULTS: After 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/day) and fosinopril (10 mg/day) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient, glucose levels of all patients increased and achieve criteria of diabetes diagnoses.


Immunosuppression related to HIV infection, immunosuppressive treatment, organ transplantation, and neoplastic diseases increases the risk for Leishmania-infected people to develop visceral illness.


Contact dermatitis, an inflammatory response of the skin to an irritant or an allergen, can affect hospital staff.


Donepezil for behavioural disorders associated with Lewy bodies: a case series.


A left L1 transforaminal approach was successful, and 1 mL of iopamidol (Isovue) contrast was injected, followed by 5 mL of a solution of 0.125% bupivacaine and 40 mg of triamcinolone.


There is no information to support the possibility of increase risk of late pregnancy complications or change in the natural course of the disease.


Moreover, because the patterns of response to ipilimumab differ from chemotherapy, we need to understand how and when patients may respond to treatment so that appropriate clinical decisions can be made.


Two cases of lepromatous leprosy with erythema nodosum leprosum who were on high doses of clofazimine, showed discoloration of nail plate, subungual hyperkeratosis and onycholysis.


There was no clinical evidence of immunosuppression or any obstructive lesion in the esophagus.


The lesions resolved completely approximately 30 min after removal of the hands from water.


The carbonic anhydrase inhibitors that are used most frequently in ophthalmic practice are acetazolamide and methazolamide.


"St. Anthony's fire" may be due to stimulation of alpha-adrenergic receptors in the peripheral vasculature.


Digoxin serum levels and toxicity risks increase with the addition of amiodarone.


Awareness of this route of intoxication might be important in patients in whom neurologic or psychiatric symptoms develop while large amounts of lidocaine cream are being used.


In the brain, the following distribution of olanzapine was determined (mg/kg): negative (cerebellum), 0.22 (hippocampus), 0.86 (midbrain), 0.16 (amygdala), 0.39 (caudate/putamen), 0.17 (left frontal cortex), and 0.37 (right frontal cortex).


We report a rare case of recurrent (stuttering) priapism in a patient with protein C deficiency while maintained on Warfarin therapy.


Pathologic findings demonstrated on MR were (1) chronic brain edema, demonstrable over a period of 3-14 months (proved by autopsy in one patient); (2) multifocal white matter necrosis; and (3) deep brain atrophy.


Usefulness and sensitivity of the neuro-otological examination in the field of dysequilibrium of central disorder as well as peripheral vestibular disorder is emphasized.


An unusual course of infection with Mycobacterium malmoense is described in a patient receiving chronic but mild immunosuppressive therapy for rheumatoid arthritis.


Puberty started at 11.2 years and menarche occurred at 12.7 years.


Acarbose treatment of infant dumping syndrome: extensive study of glucose dynamics and long-term follow-up.


The occurrence of this entity is linked to the presence of circulating leukoagglutinins.


We report on a child with fatal valproate-related hepatotoxic effects despite this supplementation.


Recommendations are made for the prophylaxis and treatment of sulfadiazine-related renal toxic reaction.


We report on a patient with subarachnoid haemorrhage who developed an acute life-threatening pseudo-obstruction of the colon, a variant of adynamic ileus, while being treated with intravenous nimodipine.


SUMMARY: A 26-year-old man with bipolar disorder, seizures, and mild mental retardation secondary to a traumatic brain injury began treatment with carbamazepine for aggression and seizure control.


This case showed sequential manifestation from transient thyrotoxicosis to the appearance of TSH-receptor autoantibodies, and then the occurrence of Graves' hyperthyroidism during IFN therapy.


CONCLUSIONS: Patients receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as carotid insufficiency, coagulopathy and poorly controlled diabetes mellitus.


The prosthesis acts as a porous membrane which allows two opposite flows: the passage of blood from graft to bowel and germ migration from naturally septic bowel to blood.


We report a premature infant who developed seizures associated with intraventricular administration of nafcillin and discuss the need for electroencephalographic monitoring of patients receiving intraventricular antibiotics.


It has been suggested that quinolones may produce an epileptogenic effect by inhibiting the binding of gamma-aminobutyric acid to its receptor sites in the brain.


Theophylline intoxication mimicking diabetic ketoacidosis in a child.


We report a patient receiving chronic lithium therapy who presented with a transient CDI occurring in the setting of underlying chronic NDI.


As with our patient, many of these case reports described clinicians who overlooked thrombosis due to HDAs because the patients did not have HIT.


Low doses of topiramate are effective in essential tremor: a report of three cases.


In our case, renal biopsy revealed diffuse proliferative glomerulonephritis with findings of active cellular immunity, and aggressive treatment resulted in attenuation of these findings.


Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis.


We report a case of hyponatremia associated with a grand mal seizure in a 28 month-old child after intra-nasal desmopressin administration for high fluid intake with nocturnal enuresis.


However, alkylating agents overwhelmingly predominate as the class of compounds which are most often associated with terminal ANLL.


We report a cae of paranoid psychosis following use of a decongestant containing PPA and summarize the case report literature of psychiatric adverse effects to PPA in which doses were known and stated to be within recommended guidelines.


Bipolar disorders as well as recurrent major depressive episodes can be most effectively treated with electroconvulsive therapy (ECT).


Desipramine and testicular swelling in two patients.


This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.


Propylthiouracil-induced cutaneous vasculitis.


Pneumocystis pneumonia should be considered in asthmatic patients taking methotrexate who present with fever, pulmonary infiltrates, and hypoxia.


CONCLUSIONS: The value of multihormonal therapy in breast carcinoma is not established, and the addition of progestogens to tamoxifen may not reduce of developing endometrial lesions, including carcinoma.


One other patient on digoxin stopped taking it and developed cardiomyopathy.


The clinical, radiological and EEG findings during and post event are presented and are in keeping with a diagnosis of RPLES.


Other causes of liver failure, such as viral hepatitis, autoimmune hepatitis, toxins, and heart failure, were excluded by appropriate diagnostic means.


This case shows that strong in vivo and in vitro cross-reactivity between standard heparin and LMW heparins may occur, but can be avoided by the use of a novel heparinoid, Org 10172.


CD4 T-lymphocyte depletion, myelosuppression, and subsequent severe infections are the major side effects of fludarabine phosphate therapy.


Gastric-outlet obstruction induced by prostaglandin therapy in neonates.


Asthmatic patients receiving antileukotrienes may develop hypereosinophilia as a part of a Churg-Strauss syndrome.


A reversible toxic liver damage was observed in a non-alcoholic woman treated with disulfiram.


An adverse reaction to IFN was strongly suspected as the cause of CHF.


Culture and cytology of lavage fluid were negative.


We are unaware of previous reports of P. avidum hip arthritis.


All 3 patients underwent allogeneic bone marrow transplantation.


It has multiple adverse effects including neurotoxicity.


The authors present the first reported case of toxic shock syndrome associated with its use.


A 31-year-old female developed multiple episodes of grand mal seizures after combination chemotherapy with cisplatin, vinblastine and bleomycin for germ cell ovarian cancer stage Ic.


Furthermore, rechallenge with sertraline caused CK and myoglobin to again increase, which was reversed following a discontinuation of sertraline.


The etiopathogenesis and management of this condition are presented.


A 41-year-old black female with psoriasis developed photosensitivity and a Koebner reaction while receiving phototherapy.


We report quadriparesis as a result of severe hypokalaemia and acidosis in a 50-year-old man who had undergone ureterosigmoidostomy for bladder extrophy 48 years earlier.


METHODS: Small case series.


When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity.


Infant twins sustained severe circumoral and pharyngeal burns from a concentrated solution of benzalkonium (Zephiran) chloride prescribed for treatment of candidiasis.


We report a t(4;11)(p12;q23) with rearrangement of MLL and FRYL (also known as AF4p12), a human homolog to the furry gene of Drosophila, in an adult patient with therapy-related AML after fludarabine and rituximab therapy for small lymphocytic lymphoma and radiation therapy for breast carcinoma.


Although priapism has been associated with other serotonergic antidepressants, no published reports have correlated restoration of sexual potency with use of fluoxetine.


The following risk factors were determined: History of glaucoma or other ophthalmological problems, prolonged cardiopulmonary bypass-time and myocardial ischemia, general oedema during cardiopulmonary bypass, excessive hemodilution with low hemoglobin and hematocrit, hypo- or hypertension, systemic hypothermia, need for vasoactive medication.


This complication occurred 14 days after the commencement of highly active antiretroviral therapy (HAART) for advanced HIV infection.


RESULTS: A 33-year-old man with extensive ophthalmologic complaints and procedures, who had used glucocorticoid ocular drops for an extended period, was referred to the endocrinologist for new onset of type 2 diabetes mellitus.


Remission was achieved without hospitalisation in over 60% of patients.


Cesium-induced QT-interval prolongation in an adolescent.


SUMMARY AND CONCLUSION: The case presented shows the rare occurrence of the congenital absence of an IVC with pelvic thrombosis in a young female with a history of menorrhagia and new onset of pelvic pain.


The analysed carbachol concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260.


DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.


We describe a patient who became hypothyroid while taking ferrous sulfate.


Neuralgic amyotrophy is a rare condition of unknown etiology that has never before been associated with administration of these antibiotics, individually or in combination.


Acute intravascular hemolysis developed when a diabetic patient, previously treated with glyburide, was started on another oral sulfonylurea drug, chlorpropamide.


It is suggested therefore that methotrexate be added to the list of agents capable of inducing diffuse interstitial pulmonary fibrosis.


In these four patients, plasma carbamazepine concentrations after clarithromycin coadministration were approximately twice as high as those after its discontinuation.


In a series of 104 cases of intentional or inadvertent use of zidovudine at differing gestations in pregnancy, there were eight spontaneous first trimester abortions, eight therapeutic terminations, and eight cases of fetal abnormality occurring among a total of 88 cases where the pregnancy progressed.


We report the case of a 60-year-old woman who developed erythema and erosions in the axilla and groin while on PLD for breast cancer.


Preoperative diagnoses were multiple graft failures, chemical burn, Stevens-Johnson syndrome, or ocular cicatricial pemphigoid.


During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding, a 50-year-old male with no history of heart disease developed a newly prolonged QT interval and torsade de pointes.


Mycological examination confirmed the presence of fungus, Trichophyton rubrum, and the diagnosis of Majocchi's granuloma of the face was made.


Treatment with volume expansion, hypertonic sodium bicarbonate, inotropic support with norepinephrine and insertion of an intra-aortic balloon pump led to complete recovery after 72 hours.


The corresponding urine concentrations amounted to 374 and 554 mg/l.


Ritonavir acted as a CYP3A4 inhibitor, diminishing carbamazepine metabolism and provoking an increase in serum levels and clinical toxicity.


CBF was decreased by 35% (p < 0.05) in the VVR group.


A conventional 300-mg clopidogrel loading dose needs to be administered at least six hours before PCI to achieve an adequate antiplatelet effect.


Attenuation of asparaginase-induced hyperglycemia after substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation.


We report a patient who initially presented with localized Ewing sarcoma and later developed metastatic disease that required dose-intensified chemotherapy.


We describe the use of the Naranjo adverse drug reaction probability scale to establish causality in three cases of suspected anticonvulsant hypersensitivity syndrome with the aim of introducing clinicians to this effective tool.


Our findings may contribute to the understanding of leprosy reactions pathogenesis, broaden the knowledge about their outcome with standard treatment, and provide the scientific background to design better therapeutic strategies for these complications.


Toxoplasma gondii encephalitis is an important opportunistic infection in the acquired immunodeficiency syndrome, estimated to occur in 20,000 to 40,000 patients with acquired immunodeficiency syndrome in the United States by 1991.


A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.


Although other nitrites induce methemoglobinemia, exposure to methyl nitrite during phenylpropanolamine production appears to be a new cause of occupational methemoglobinemia.


The partial lesion of the cord at T7 predominantly involved the spinothalamic pathways on the left side.


A 17-yr-old boy with Crohn's disease and growth retardation developed an acute abdominal crisis while receiving total parenteral nutritional support.


SETTING: Spinal cord rehabilitation center, University Hospital.


Interstitial nephritis is a rare but serious adverse effect of many drugs and usually is diagnosed by clinical signs and symptoms of hematuria, proteinuria, eosinophilia, fever, azotemia, and rash.


We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia.


The improvement in sexual response was seemingly unrelated to abatement of depression or obsessive compulsive disorder, and there was no description of priapism by any of the patients.


According to American Society for Aesthetic Plastic Surgery (ASAPS), 200,924 people had rhinoplasties in 2005.


Angioimmunoblastic lymphadenopathy with retinitis and drug related exacerbations: a clinicopathological case study.


We report a case of Graves' hyperthyroidism induced by long-term interferon (IFN) therapy.


We describe a life threatening side effect of acute epoprostenol infusion (pulmonary edema) in a patient with pulmonary hypertension associated with limited scleroderma and discuss its management and potential etiology.


A liver biopsy obtained 10 days after the initial presentation revealed centroacinar necrosis and beginning fibrous reorganization, compatible with recent centroacinar damage.


Vasculonecrotic reactions in leprosy.


The long-term effect on corneal endothelium has to be studied further.


The evolution was favourable without treatment.


Intrathecal administration of amphotericin B is the best method of eradicating intracranial fungal infections.


To the best of our knowledge, this has not been reported previously in the emergency medicine literature.


Hence, measures to avoid ischemic optic neuropathy have priority.


We describe the first documented case of azathioprine-induced severe myelosuppression due to thiopurine methyltransferase deficiency in autoimmune liver disease.


Prevalence of antiprotamine immunoglobulin E antibody.


Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C.


On this regimen, relative clearing of the psoriatic lesions has been achieved with no significant side effects.


From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).


One case of priapism occurred during heparin therapy for a previous surgical operation to the knee is reported.


She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.


The histological study of the duodenal biopsies showed villus atrophy.


DISCUSSION: Carboplatin is an important chemotherapeutic agent in the treatment of a variety of pediatric brain tumors.


This report describes four patients with variant angina and one patient with rest angina who had coronary spasm that was refractory to sublingual or i.v. nitroglycerin.


Factors relating to her case have been reviewed in the literature.


A 66-year-old female with chronic renal failure was referred to our hospital because of drowsiness and an acute deterioration of renal function.


OBJECTIVE: This case report outlines a significant type of morbidity due to continued use of gabapentin during an episode of acute renal failure.


The authors report one case of incomplete posterior hyaloid detachment (PHD) following intravitreal pegaptanib to treat DME.


One wk later, after injection in the right arm, skin lesions and pruritus were seen.


Trazodone-induced transient hypomanic symptoms and their management.


OBJECTIVE: To present a single case of zuclopenthixol-induced priapism and a literature review.


Blood glucose levels returned to normal after cessation of therapy, but dropped again following rechallenge with the drug.


Imatinib, a tyrosine kinase inhibitor, is currently the therapy of choice for gastrointestinal stromal tumor (GIST).


METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.


Lipodystrophy and serum lipid abnormalities in HIV-positive sub-Saharan population on ART.


Cutaneous reaction to drugs used for erectile dysfunction: case report and review of the literature.


A 15-kg weight gain developed in a patient during the third week of ibuprofen therapy.


Patients were scored using the dyskinesia scale and started treatment with 400 mg amantadine (po) for 4 days within the first postoperative week with no effect on dyskinesia score or its phenomenology.


This report describes the case of a 58-year-old female patient with treatment-refractory schizophrenia who was successfully switched from clozapine 300 mg/day to aripiprazole 20 mg/day because of changes in consciousness.


The remaining pregnancy, delivery and follow-up period were uneventful for the mother and her offspring.


BACKGROUND: To assess the nature, incidence, and risk factors of retinopathy associated with pegylated interferon and ribavirin combination therapy in chronic hepatitis C patients.


We describe a case of a man treated with an EGFR-inhibitor (erlotinib) for a cell lung cancer who developed skin manifestations localized in an uncommon area and with an atypical evolution.


Pyomyositis is a rare disease, encountered mainly in tropical climates.


A 13-year-old boy was diagnosed as acute lymphoblastic leukemia following radiotherapy and chemotherapy for treatment of medulloblastoma.


Representative cases illustrate the clinical manifestations of chemoradiation on the developing dentition.


We report a case of a 32-year-old man who showed paradoxical enlargement of pathologically verified intracranial tuberculomas during a course of adequate antituberculous chemotherapy.


She died 10 days after treatment was begun.


Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.


These observations have been reflected in postmarketing clinical experience, leading to recommendations that novel antipsychotics, such as sertindole, should be prescribed to first-episode patients.


There are few reported findings of sexual dysfunction in men and none in women.


Despite subsequent investigations, including analysis of urinary metabolites of organic and amino acids, measurement of serum carnitine and a muscle biopsy, we could not clarify the primary metabolic abnormalities in this girl.


Unfortunately, the patient went to another hospital located in the small city where she lived, and all remaining doses of the total course of treatment were administered over the next 5 consecutive days, with no interruption in therapy.


Range orders for the delivery of IV opioids give nurses the flexibility needed to treat patients' pain in a timely manner while allowing for differences in patient response to pain and to analgesia.


Benzalkonium chloride poisoning in infant twins.


Soon afterwards he developed cholestatic hepatitis and visual disturbance.


To our knowledge, this is the only reported case of tularemia occurring in the post-transplant setting.


After the withdrawal of TMP-SMX and the administration of high-dose steroid, these systemic symptoms gradually resolved.


Epidural abscess and meningitis, a complication of spinal anesthesia in a bacteraemic patient.


Disseminated cysticercosis.


Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.


Complete physical recovery occurred after several days of supportive treatment.


Differential diagnosis and treatment of this condition are discussed.


The diagnosis of sepsis and submandibular phlegmon was confirmed by a positive blood culture for serotype III group B Streptococcus agalactiae.


The patient experienced muscle twitches, tremulousness, and anxiety on day 17 of foscarnet therapy.


After the institution of the combined therapy with corticosteroid, anticoagulant, and dipyridamole, urinary protein excretion was attenuated to less than 1.0 g/day.


CASE SUMMARY: A 75-year-old man developed agitation, confusion, incoordination, and gait disturbance because of progressive rigidity.


We report for the first time on a patient who had isolated aspergillosis of the small bowel after autologous stem cell transplantation.


Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.


Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.


A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.


Among these are an increased incidence of both gram-positive and gram-negative infections and an increased incidence of gastrointestinal symptoms.


Clinical course of macular edema in two cases of interferon-associated retinopathy observed by optical coherence tomography.


A 63-year-old woman with seropositive rheumatoid arthritis was successfully treated with auranofin for 12 months.


Patients may not mention it among their medicines, since it is so commonly used and they regulate it themselves.


Visual changes, headache, and elevated blood pressures were present on arrival to the emergency department.


Clinicians should monitor patients closely for a decreased VPA effect when these medications are given concomitantly.


It is important that nurses understand potential side effects of these agents, know of possible interventions, and participate in research to identify effective interventions.


In this report the case of a 58-year-old female with neuropathic pain using increasing transdermal (TTS) fentanyl dosages to a maximum dose of 3400 microg/h resulting in fentanyl plasma levels of 173 ng/ml is described.


The main objective of this report is to compare and contrast the type and frequency of neuropathological findings following liver, heart, lung, heart-lung, kidney and bone marrow transplantation and to provide an overview of the major systemic complications in patients that received allografts.


It is suggested this relationship is causal rather than coincidental and mediated through cerebral arterial vasodilatation.


Early recognition of this condition and initiation of effective treatment can improve outcome.


Side effects associated with this medication are usually minor; serious complications are most often due to the delivery system required for continuous infusion.


RESULTS: Visual loss was mild and generally nonprogressive.


Here we report a patient with newly diagnosed acute promyelocytic leukemia who developed acute focal myositis, synovitis, and possible vasculitis, after receiving all-trans retinoic acid therapy.


Drug induced polymyositis secondary to leuprolide acetate (Lupron) therapy for prostate carcinoma.


The cystic larval forms (coenuri) are found in hares, rabbits, squirrels, and, rarely, in humans.


2-Chloro-deoxyadenosine induces durable complete remission in Castleman's disease but may accelerate its transformation to non-Hodgkin's lymphoma.


In our patient, symptoms were most acute during the infusion, when whole blood cyclosporine concentrations were likely to be the highest.


One patient developed large intramural esophageal hematoma as a complication of heparin therapy.


In patients with inflammatory bowel disease cytomegalovirus infection has been described in both immunocompetent and immunocompromised individuals.


The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.


Potential interaction between azithromycin and warfarin.


Colchicine-induced rhabdomyolysis.


Pulmonary lymphohistiocytic reactions temporally related to etanercept therapy.


PURPOSE: To determine the cause of spontaneous choroidal hemorrhage in a 67-year-old man after a myocardial infarction and administration of tissue plasminogen activator.


A well-recognized complication of ethambutol use is optic neuropathy, but the potential ocular toxicity of isoniazid is often overlooked.


In particular, this adverse effect has never been described with mefloquine (Lariam).


DESIGN: Morphologic, immunophenotypic, and cytogenetic analyses were performed on the 3 patients at the time of initial diagnosis, during imatinib therapy, and at blast crisis.


Upon admission, all drugs were continued except metoclopramide.


Features of both de novo AML [FAB M2 morphology, t(8;21), and "secondary leukemia" (additional cytogenetic changes, resistance to chemotherapy) were present.


A 57-year-old man developed morphea while taking bromocriptine.


Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.


The possible causes of this previously unreported early complication are discussed.


No hematologic or blood chemistry abnormalities related to L-AmpB treatment were observed.


A macrophage activation syndrome, possibly related to methotrexate toxicity, developed in a boy with systemic juvenile rheumatoid arthritis.


In one patient, APL developed 21 months after liver transplantation for ornithine transcarbamylase deficiency.


Other related symptoms presented by our patient were mood fluctuation and increased writing activity suggestive of punding.


The case illustrates the classic features of the syndrome and its dramatic response to corticosteroid treatment.


A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.


The condition should be suspected in patients who develop unexplained abdominal pain or collapse following vasopressin treatment.


RESULTS: Parathyroid hormone, parathyroid hormone-related peptide and 1,25-dihydroxyvitamin D levels were suppressed, suggesting that hypercalcemia was mediated through alternative mechanisms.


We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide.


Fournier's gangrene is a fulminant necrotizing fasciitis of the scrotum and penis, often with an infectious etiology.


A new sodium homoeostasis was established with a higher dose of DDAVP.


Photochemotherapy with psoralens and UVA (PUVA) is widely used in the treatment of psoriasis and many other skin conditions.


A 33-year-old man with a history of recreational benztropine abuse presented to the emergency department with confusion, abdominal pain, and distention.


High-density lipoprotein levels increased in both patients.


We report the case of an elderly patient who developed this unusual occurrence following an uneventful pars plana vitrectomy for a posteriorly dislocated IOL.


A cytogenetic study showed del (3)(q11.1).


The cyst can rupture and with the pre-existing steroid induced immune-suppression, the calf abscess will be hard to control.


The other patient was treated with amphotericin B and discharged, with a central venous catheter, after recovery from neutropenia.


A 67-year-old man on long-term carbamazepine therapy underwent elective coronary artery bypass grafting.


Semiselective intra-arterial chemotherapy with compression of the femoral arteries at the time of injection.


CT scan of the brain was unremarkable.


Most often the myeloblastic form of acute leukemia was diagnosed.


Subsequently he had severe hyperphosphatemia (29.3 and 14.1 mg/dl; 9.46 and 4.55 mmol/L), hypocalcemia, hyperuricemia, hyperkalemia, and azotemia.


Our results suggest that rituximab and possibly irradiated DLI played an important role in controlling early EBV-LPD in these two patients and may be an effective alternative therapeutic strategy for patients who develop EBV-LPD post transplant and are unable to receive unmanipulated DLI.


Intraocular infection due to Blastomyces dermatitidis is rare, and only 10 cases have previously been reported.


Repeat courses may be needed to eradicate infection.


A case of acute pleuropericarditis, which occurred after apparently successful percutaneous coronary intervention (PCI) for chronic total occlusion of the right coronary artery, is reported.


Chronic, low-grade endophthalmitis after cataract surgery with intraocular lens (IOL) implantation is often unresponsive to antibiotic therapy, probably because of low drug penetration into the capsular bag.


Lithium-induced Creutzfeldt-Jakob syndrome.


Complications of extensive adhesion formation after intraperitoneal chemotherapy.


Tigecycline-induced acute pancreatitis: case report and literature review.


The patient, a paraplegic, was treated with dantrolene and made a full recovery.


Furthermore, the dystonia may resolve following the disappearance of the brainstem and thalamic lesions.


Amiodarone was approved to treat recurrent ventricular fibrillation or sustained ventricular tachyarrhythmia that has been resistant to other medications since 1986.


Injury of the inferior alveolar nerve after overfilling of the root canal with endodontic cement: a case report.


Acyclovir was discontinued.


The patient was hospitalized in October, 1974, with signs and symptoms of right ventricular outflow obstruction and arrhythmia, and cardiac workup established the presence of a right ventricular tumor.


As part of the comprehensive treatment, strict reverse isolation and granulocyte-macrophage colony-stimulating factor (GM-CSF) therapy were applied.


The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus, therefore, in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment.


Six months before cessation of therapy discrete radiological signs of apical fibrosis appeared.


The case resembles two previously reported cases of optic neuropathy which occurred in patients with Wilson's disease who were receiving penicillamine.


Hyperammonemia after high-dose chemotherapy and stem cell transplantation.


She had begun taking amisulpride 50 mg/day and diazepam 2 mg at bedtime 6 months prior to the psychiatrist appointment, with poor relief of her depressed mood.


We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis in a cachectic AIDS patient with protracted diarrhoea.


The median age of these patients at the time of AML diagnosis was 39 years (range, 33-59 years), the median time from the treatment of lymphoma to AML was 18 months (range, 11-48 months), and the median survival following induction chemotherapy was 4 weeks (range, 2-16 weeks).


We diagnosed BP by histopathological and immunofluorescence studies.


Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or "cutting" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.


Several cases of nephrotic syndrome occurring after BMT have already been reported, but most cases had membranous nephropathy.


However, he had an acute onset of chest pain with fever which happened 4 h after PCI.


Spontaneous regression of the lesions was noted after discontinuation of the treatment.


In addition, we review recent data to indicate how concurrent use of antifolates may place these children at particular risk for adverse psychological reactions.


Inflammatory cells were quantitated and compared with inflammatory cells in normal upper tarsal conjunctivae.


Possible relationships between the white matter lesions and extrinsic toxic agents are discussed.


Fetal goiter is a rare disorder, usually associated with maternal thyroid disease.


Remission of lymphoma after drug withdrawal in rheumatoid arthritis.


OBJECTIVE: To report a case of multiple episodes of seizure activity in an AIDS patent following amphotericin B infusion.


Myelodysplasia terminating in acute myeloid leukemia in a hairy cell leukemia patient treated with 2-deoxycoformycin.


We recommend careful use of ifosfamide in patients pretreated with nephrotoxic chemotherapy and inadequate renal perfusion.


Raynaud's phenomenon and acral necrosis after chemotherapy for AIDS-related Kaposi's sarcoma.


The changes were those of nodular hyperplasia, sclerosis of terminal hepatic venules with associated zone 3 hemorrhagic necrosis, and sinusoidal fibrosis.


When folinic acid was ceased on the day of methotrexate in these patients their psoriasis improved.


Intraocular use of rituximab.


Oral vancomycin is often considered the drug of choice for severe Clostridium difficile-associated disease due to both its efficacy and pharmacokinetics.


Long QTc and torsades de pointes in human immunodeficiency virus disease.


RESULTS: After 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/day) and fosinopril (10 mg/day) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient, glucose levels of all patients increased and achieve criteria of diabetes diagnoses.


Conservative treatment with oxygen was administered and both respiratory and liver disorder resolved 4 weeks following admission.


The hematologic response parameters and clinical outcomes to each of the therapies given are described.


Only experienced clinicians should administer chemotherapy, and thorough records must be kept to document the chemotherapy administered, dosages, dates of administration, the procedure used, and the schedule of cycles administered.


At autopsy, the liver was found to be small, shrunken, and scarred; histological sections demonstrated postnecrotic cirrhosis.


While a lower systemic steroid dosage may have been the provoking factor, we feel that an adverse reaction to oleic acid, a dispersing agent in the aerosol freon vehicle, is a strong possibility.


Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy.


We describe three infants exposed in utero to ACE inhibitors who had adverse outcomes.


Analysis of the case which went to trial indicates that there is not one prescribed protocol which must be followed; the definition of standard of care is broader than that.


Percutaneous renal biopsy revealed that she had minimal change nephrotic syndrome.


This result suggests that a change in the serotonin reuptake mechanism may be involved in the effect of nc-EST on depression.


This case suggests a role for IgE in the hypersensitivity reaction.


The patient was treated with polyhexamethylene biguanide and chlorhexidine for 3 months, and recovered with normal visual acuity.


G-banding analyses of bone marrow cells had repeatedly demonstrated normal male karyotype before this event, but t(9;22)(q34;q11) was demonstrated after the event.


In one of these patients olanzapine was well tolerated when reintroduced in combination with lorazepam after complete remission of akathisia.


The reduced retinal edema and realignment of the photoreceptors may promote the release phenomenon and trigger hallucinatory episodes.


In addition to treating the otorrhea with ear drops, one physician would add oral antibiotics (Dr.


CASE DESCRIPTION: A 59-year-old man with known neurocysticercosis developed a large cerebral infarction during praziquantel therapy.


The patient underwent craniotomy, with resection of two lesions in close proximity within the parenchyma of the temporoparietal lobe.


Grade 3 hepatotoxicity (AST and ALT > 5 to 20 upper limit normal) or higher has been observed in as many as 1.4% of MS patients on IFN beta.


Prosthetic joint infection is an infrequent but serious complication of total joint arthroplasty.


Plasma samples of our patients were initially considered positive for tricyclic antidepressants because the cross-reaction of carbamazepine gave tricyclic antidepressant concentrations as imipramine equivalent sufficiently above the assay cut-off point (20 ng/mL).


Essential thrombocythemia in a dog: case report and literature review.


METHODS: Due to the lack of efficacy of subsequent treatment of conventional and other atypical neuroleptics, treatment with clozapine was restarted after discontinuation.


Upon withdrawal of ibopamine but continuation of all other drugs, the patient recovered from the blood dyscrasia within 5 days and showed resolution of symptoms.


Renal biopsy showed diffuse proliferative glomerulonephritis with cellular crescents.


Urine toxicology screening was negative.


The VAS decrease for this patient was 14.3%.


PURPOSE: To report a case of traumatic flap dehiscence and Enterobacter keratitis 34 months after LASIK.


This case report describes a rare combination of facial dermatologic toxicity and ectropion.


A variety of movement disorders are known to occur in association with carbamazepine (CBZ) therapy in adults and children, but development of tics has been described infrequently and only in patients with underlying Tourette's syndrome or other movement disorders.


The dermatitis did not resolve with 15 months of traditional treatments.


The results and the importance of serial neuropsychological examinations after such complications in three children with ALL are presented.


The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma.


Hypoxia is a predisposing factor for premature ductal closure and often occurs after maternal indomethacin therapy.


In both cases, the diagnosis of PTE was based on clinical assessment of sudden acute respiratory failure with positive pulmonary perfusional scintigraphy in spite of a negative chest X-ray.


Mitral valve prolapse and thromboembolic disease in pregnancy: a case report.


Proposed mechanisms for phenytoin hypersensitivity include antigen-antibody reactions, alteration of lymphocyte function, and an enzyme abnormality causing the production of toxic metabolites.


Two cases of complications of the thrombolysis of right heart free-floating thrombi with pulmonary embolism: important role of echocardiographically based management.


Rippling muscle disease is a rare autosomal dominant disorder that may occur sporadically.


To the best of our knowledge there have been no previous reports of AGEP induced by the ingestion of nimesulide in the medical literature.


We describe two patients in whom painful erosions of their psoriasis developed as the presenting sign of methotrexate toxicity and review the literature, emphasizing the risk factors associated with this manifestation.


One month later recurrence appeared in the right eye, as a central corneal infiltrate in the graft.


SETTING: Tertiary pediatric cardiac center.


Unopposed endogenous and exogenous estrogenic stimulation has been considered by most investigators to have a role in the pathogenesis of carcinoma of the endometrium.


One of the occult blood cards showed a positive result, and colonoscopy revealed a 5-cm lesion, identified as Dukes' A adenocarcinoma.


Infections with multi-resistant organisms such as methicillin-resistant Staphylococcus aureus in ventricular assist device recipients are often difficult to treat and present a high mortality rate.


Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.


Comparable adverse effects, such as disorientation and temporary amnesia, have been reported in patients in the analogous agent, propranolol.


Phenytoin toxicity due to concomitant antituberculosis therapy.


OBJECTIVE: To report the occurrence of acute cytolytic hepatitis in a patient exposed to pulse itraconazole therapy for 24 weeks and provide a concise review of the literature on cases of itraconazole-induced hepatitis.


Naproxen-associated sudden sensorineural hearing loss.


Within two months, the ophthalmic abnormalities had resolved.


Their charts were evaluated in depth, and the literature was reviewed in regard to possible etiopathologic mechanisms.


Best known are urticaria, erythema, and pruritus; sometimes pseudoallergic anaphylactoid reactions, and blisters are reported.


Due to the difficulty in identifying and verifying exposures to such agents, only a few chemical compounds are clearly linked to malignancies.


Uncontrolled bleeding during endodontic treatment as the first symptoms for diagnosing von Willebrand's disease.


Eight of the 10 eyes were receiving topical steroids at the time of presentation.


Compared to the normal study protocol side-effects such as renal failure were not observed probably due to sufficient fluid intake and good clinical condition prior to treatment and to the rapid and persistent ductal closure.


CD20-negative T-cell-rich B-cell lymphoma as a progression of a nodular lymphocyte-predominant Hodgkin's lymphoma treated with rituximab: a molecular analysis using laser capture microdissection.


Lidocaine therapy was started, and the patient was transferred to a cardiac intensive care unit at our hospital.


Soon after starting subcutaneous erythropoietin, the velocity of progression of renal failure slowed whilst no more blood transfusions were required and haptoglobin levels returned to normal.


Immunoblastic lymphoma developed in a patient diagnosed as having angioimmunoblastic lymphadenopathy 5 years earlier.


Repeat catheter and peripheral culturing occurred 72 hours after the 5-day period.


We report two children with HC pneumonitis and pneumatoceles as a reversible complication after ingestion and aspiration of lamp oil with very low viscosity.


Anaphylactoid reactions with intraperitoneal cisplatin.


These three men had no known history of familial or personal thyroid disease.


Its main mechanism of action is regarded as a switch of the immune reaction from a T helper (Th)1 to a Th2 cell type.


Postoperatively, the first two patients treated with 1 to 2 cc of thrombin were slow to awaken; one had evidence of vasospasm by transcranial Doppler ultrasound studies and multiple infarcts on cranial computerized tomography, while the other had a moderate-sized frontal hematoma with intracranial hypertension.


We report sporotrichoid spread of Mycobacterium marinum in a 37-year-old woman with Crohn's disease, who had been receiving infliximab infusions for 2 years.


The patient subsequently responded well to intravenous antibiotics, intravenous corticosteroids, and local wound care.


Therapeutic efficacy of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with metastatic melanoma unresponsive to prior systemic treatments: clinical and immunological evidence from three patient cases.


We compared patient reports with reports from healthcare professionals.


We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative.


Although its overall safety profile is good, a few cases of toxic epidermal necrolysis have been reported.


A 23-year-old woman with metastatic Sertoli-Leydig cell tumor was treated with cisplatin, vinblastine, and bleomycin.


This case describes fulminant hepatic failure in a patient taking disulfiram with no previous liver disease and report of being compliant with alcohol abstinence.


Lithium (Eskalith) is commonly used in the treatment of depressive and bipolar affective disorders, in a population at relatively high risk for overdose.


INTRODUCTION: Visual loss is a rare complication of tuberculosis; it can be related to anti-tuberculous drugs or to the infection itself.


Palpable purpuric skin lesions on the anterior surface of both legs appeared on the 55th day of amphotericin B treatment.


Urine glucose and single afternoon blood glucose determinations were inadequate and potentially misleading in monitoring diabetic cats receiving excessive amounts of insulin.


Surveillance in the intensive care unit is mandatory during readministration of the drug.


A case report of a patient with probable cisplatin and bleomycin-induced TMA is presented.


The patient presented with headache, left facial and orbital pain, nasal discharge, and elevation of serum creatinine 18 months after kidney transplantation.


Our purpose is to highlight the dangerous means adopted by unlicensed medical charlatans to induce abortion as well as to emphasize the key role played by anesthesiologists in the management of such cases.


However, peripheral neuropathy and bone marrow depression led to linezolid withdrawal in seven patients, and neuropathy may not be fully reversible in all patients.


Hepatic Sinusoidal Obstruction Syndrome in a child after chemotherapy for medulloblastoma.


The patient was then dialyzed for presumed acyclovir toxicity.


We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose.


Complete clinical-electroencephalographic recovery was achieved after lithium therapy was discontinued.


Currently the use of zidovudine is one of the few specific measures available, and as a potentially teratogenic and fetotoxic agent, any decision for its use requires evaluation of the potential for fetal damage.


High-dose intravenous mannitol infusion in various clinical settings may result in acute renal failure (ARF).


PURPOSE: To investigate the concentration-side effect relationship in a patient with severe acyclovir-induced neurotoxicity and to summarize the information available in the literature about central nervous system side effects due to acyclovir.


Effect on levels of intercellular antibodies in pemphigus vulgaris.


BACKGROUND: A 68-year-old man diagnosed with primary plasma-cell leukemia was given thalidomide maintenance treatment for his disease.


BACKGROUND: Visceral leishmaniasis is a protozoan infection usually asymptomatic, but can progress to fatal disease in immunocompromised hosts, especially in HIV patients.


Liver abscess in patients with a VP shunt should be considered a possible abdominal complication of the VP shunt, and may be caused by unusual pathogens.


We report 2 cases of maculopapular eruption and fever in patients infected with human immunodeficiency virus (HIV) on the 2nd day of first administration of ritonavir, a protease inhibitor.


Bone injury while undergoing electro-convulsive therapy is thought to be rare.


Metastatic osteomyelitis following BCG vaccination.


Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction.


We report a patient with a recurrent supratentorial pilocytic astrocytoma who had an untoward interaction between high-dose tamoxifen therapy and phenytoin (PHT), drugs that share a common enzyme for metabolism, therefore emphasizing the need to monitor concomitant antiepileptic drug (AED) levels when high-dose tamoxifen therapy is instituted.


Laboratory abnormalities included a prothrombin time < 10%, an international normalized ratio exceeding the laboratory limits, and an activated partial thromboplastin time >120 seconds.


We explored ophthalmic and neurologic findings in two children who have been exposed prenatally to VGB.


Captopril is known to be associated with dermatologic, hematologic, and pulmonary adverse effects.


We report a 45-year-old psoriasis patient who developed eruptive mollusca contagiosa during an antipsoriatic treatment with efalizumab.


An intertrigo-like eruption from pegylated liposomal doxorubicin.


MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation.


We describe a patient who presented with bloody diarrhoea after 15 mg meloxicam daily for 10 days for osteoarthritis.


She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.


Histological examination of liver biopsies showed diffuse microvesicular steatosis.


Camptocormia, a new side effect of sodium valproate.


An interaction between cytostatic and anticonvulsant drugs.


This case report describes the use of a Q-switched neodymium:YAG laser to puncture miotic cysts.


This is the first report of non-convulsive status epilepticus provoked by tiagabine in adolescent patients.


In contrast, none of 27 nondiabetic healthy normal controls or 10 diabetics who had never received protamine or protamine-containing insulin had levels of antiprotamine immunoglobulin E over background.


In the present study, we present three cases in which patients with resistant schizophrenia and comorbid alcohol use disorder were given lamotrigine to augment clozapine.