Despite early complete paraplegia, some neurological and functional recovery was observed.


CPSs sometimes breach the transverse foramen without rupture of the VA.


A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.


We report a 4-year-old girl who presented with acute bilateral blindness, a focal seizure and hypertension 10 days after commencing oxybutynin to treat enuresis.


We report a 78-year-old man who had acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia.


On day 15 of cycle 1, he reported progressive worsening of weakness and fatigue, and melena.


After four months, while receiving RH, he developed painful bilateral gynaecomastia.


A patient with monocular open-angle glaucoma had trichiasis, a condition associated with the use of a prostaglandin analog.


Bilateral simultaneous achilles tendon ruptures.


Later in the clinical course, the myoclonus became stimulus sensitive and was induced by tendon tap given anywhere on the body, with the latency ranging from 50 to 150 ms irrespective of the sites of tapping.


Thiopurines such as azathioprine (AZA) and 6-mercaptopurine are frequently used for the treatment of inflammatory bowel diseases.


Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine.


Many months after termination of the chemotherapy and 15 months after placement, she presented with bowel contents per vagina.


Successful bone marrow transplantation from an unrelated donor in a patient with adult T cell leukemia.


We describe a 69-year-old female who received tigecycline for treatment of a complicated skin and skin-structure infection.


Phenylephrine dosages for topical use ranged from 50 to 367 times greater than the i.v. dose required to increase arterial pressure by 50% in anesthetized dogs.


Continued occurrence of Accutane-exposed pregnancies.


A 50-year-old male patient was started on erlotinib as a third-line chemotherapy.


The diagnostic pitfalls are discussed with the case, and the need for careful interpretation of laboratory findings in conjunction with clinical signs is emphasized.


During this time the corneal infiltrate became less prominent but visual acuity remained impaired by both corneal opacity and cataract.


Two cases of lepromatous leprosy with erythema nodosum leprosum who were on high doses of clofazimine, showed discoloration of nail plate, subungual hyperkeratosis and onycholysis.


Radiation pneumonia complicating adjuvant cytotoxic chemotherapy.


They suggest that lithium-antidepressant combination can precipitate this syndrome.


We describe a patient with M4 AML treated with standard chemotherapy followed by G-CSF who developed marked monocytosis on day 8 of G-CSF therapy.


Its overall toxicity is considerably less compared to standard induction chemotherapy; however, it is associated with a high incidence of a potentially fatal symptom complex referred to as "retinoic acid syndrome." This report describes a patient with APL who developed the syndrome a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis.


Late free-flap salvage has been described with poor long-term results.


Despite vigorous therapy, severe hypoventilation and hypoxemia persisted with mechanical ventilation.


Mitomycin-C is used widely in the treatment of malignancies and is associated with serious dose related adverse effects including the occurrence of hemolytic uremic syndrome.


We therefore strongly argue in favor of extended screening recommendations for infectious diseases including viral infections before considering a therapy with infliximab.


OBJECTIVES: The examination of potential associations between Graves' disease and thyrotropin-producing pituitary adenoma (TSHoma) after treatment using octreotide, and of the expression of peroxisome proliferator-activated receptor gamma (PPAR gamma).


Reye syndrome (RS) is believed to occur infrequently among children receiving long-term aspirin therapy.


In particular, combined oral contraceptives (COCs) are known to enhance the risk for VTE and are therefore contraindicated.


Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.


Animal studies suggest that incontinence secondary to serotonergic antidepressants could be mediated by the 5HT4 receptors found on the bladder.


In both patients with a SAH caused by an aneurysm, transcranial Doppler sonography demonstrated vasospasm of the basal cerebral arteries.


A 54-year-old man developed TEN 4 weeks after beginning lamotrigine for complex partial seizures related to a glioblastoma multiforme brain tumor.


The increased use of cytostatic drugs, which are sometimes used in combination chemotherapy, may result in new and unusual cutaneous side effects.


Cutaneous sarcoidosis during interferon alfa and ribavirin treatment of hepatitis C virus infection: two cases.


A 61 year-old male patient developed gynecomastia after starting theophylline.


We report a case of visceral leishmaniasis in a 38-year-old renal transplant recipient living in an endemic country.


CLINICAL FINDINGS: On auscultation of the lungs and air sacs, crackles were detected; the abdomen was distended and fluctuant on palpation.


When tested in ferrets, the mutant virus had less virulence than the parent; however, it had a growth preference over the parent in zanamivir-treated animals.


The case of a 32-year-old man with schizophrenia and narcolepsy, two seemingly unrelated disorders, is discussed from the perspective of the diagnostic and therapeutic challenges raised by their coexistence.


CONCLUSIONS: This study confirmed that in most patients MTX-induced liver cirrhosis is not aggressive.


Nocardia Asteroides was isolated from fine-needle aspiration material of the thyroid abscess.


Proteinuria resolved after the initiation of oral prednisolone therapy (1 mg/kg per day).


53-year-old woman with a history of deep vein thrombosis and pulmonary embolism was receiving warfarin to prevent thromboembolic complications; her international normalized ratio (INR) had been stable for 1 month.


Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.


We present a case of drug-induced acute interstitial nephritis (AIN), complicated with ARF, in a 2(1/2) -year-old girl with active INS.


We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.


Gemcitabine is a known risk factor for hemolytic uremic syndrome (HUS), which can often have a rapidly fatal clinical course despite intervention with steroids, plasmapheresis and hemodialysis.


1). There was no involvement of other intertriginous sites and there were no associated systemic symptoms.


The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction.


Successful use of sodium ferric gluconate in sucrose in a patient with multiple drug allergies.


A 57-year-old white male with unresectable pancreatic cancer received capecitabine in combination with radiation therapy followed by capecitabine alone given over approximately a 3-month time period.


When the dose of 0.5 mg tid was discontinued, the obsessive-compulsive symptoms resolved with no return over 8 months of follow-up.


We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.


Tamoxifen retinopathy.


We believe the temporal association of the abnormal liver enzymes in this patient, in the absence of other offending agents, argues strongly in favor of 6-TG as a cause of liver enzyme abnormalities.


This report describes a case of acute compromise of renal function associated with hypotension in a 7-year-old boy treated with the ACE inhibitor lisinopril and the ARB losartan.


All symptoms resolved with drug withdrawal.


Patient was given 4 mg of subtenon's triamcinolone acetate in the area of the nodular scleritis and had complete resolution.


Laboratory parameters revealed a markedly elevated C-reactive protein of 189 mg/l, antinuclear antibodies of 1:2,560, a hemoglobin level of 9.0 g/dl, and a severe lymphopenia (total lymphocytes 49.4/microl, CD4(+) cells 2/microl, CD8(+) cells 7/microl).


Evidence of disseminated varicella infection was confirmed at autopsy.


Three patients are presented in whom life-threatening cardiac arrhythmias dominated the clinical presentation.


However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.


Optimizing antidiabetic treatment options for patients with type 2 diabetes mellitus and cardiovascular comorbidities.


She developed a febrile illness associated with severe pancytopenia and leukocytoclastic vasculitic rash followed by diffuse adenopathy, with serologic and pathologic evidence of EBV infection.


RESULTS: [1] Mucin secretion was increased by 63% over the controls in the VVR in vitro group (p < 0.01).


A multi-drug intoxication fatality involving Xyrem (GHB).


Nephrotic syndrome in a multiple sclerosis patient treated with interferon beta 1a.


This is the first report to illustrate the implementation of an lndium (111) DTPA flow study without interrupting the infusion of CITB.


over the past 3 years there have been several reports of uveitis associated with rifabutin therapy.


Following an initially uncomplicated recovery, he developed symptomatic hyponatremia.


Abdominal wall ulceration and mucinosis secondary to recombinant human interferon-beta-1b.


After the first year of transplantation, allograft coronary artery disease (ACAD) is the second main cause of death.


A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.


Intravitreal corticossteroids have been used for therapeutic purposes in optimum doses and adverse reports have not been described.


Long-term complication of L-asparaginase treatment.


Our report suggested that CBDCA hypersensitivity was correlated with the total dose of previously administered platinum agents and that CBDCA should be excluded in patients who have received multiple platinum-based chemotherapy, even in platinum-sensitive cases, because CBDCA hypersensitivity can occur even with low-dose CBDCA administration.


We report a case of unintentional overdose of oral pilocarpine tablets that resulted in bradycardia, mild hypotension, and muscarinic symptoms in a patient with Sjogren's syndrome.


Adequate arterial PO2 could only be achieved with the use of positive endexpiratory pressure (PEEP).


Lesions exceeded the confines of adjacent vascular territories.


Intraarticular sodium hyaluronate injection to treat osteoarthritis is associated with minor side effects.


A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.


Other practolol related side effects are usually present in the patient.


Based on the limited knowledge of the natural history of herpetic esophagitis and lack of prospective antiviral trials, symptomatic therapy with viscous Xylocaine appears reasonable.


Light microscopic examination of tissue sections, stained with hematoxylin and eosin and in some cases with special stains were made.


Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.


The cause is unknown, but the eruption may occur in association with certain medications.


As far as we are aware, there are no published reports of early replacement of an intrathecal catheter in patients with neurological sequelae.


Although the exact mechanism is unknown, the time course and constellation of symptoms are consistent with a possible inflammatory pathophysiologic condition.


Serial blood determinations suggested re-exposure in four of the patients, and in one of these patients the re-exposure was from a different source of lead.


Routine endomyocardial biopsy showed acute rejection of less than grade Ib, and the patients were discharged on the 65th and 46th postoperative day, respectively.


An obese patient, not diabetic, treated with metformin for some weeks, was referred to us with severe inferior digestive hemorrhage, diagnosed with Meckel's diverticulum.


Fulminant liver failure has not previously been described with concomitant use of atenolol and N-acetylcysteine.


The ocular motor disturbances are probably an expression of regional 5-FU neurotoxicity primarily affecting the brain stem.


Corynebacterium Group JK organisms are common contaminants of the normal skin flora.


We present a case of hypereosinophilia related to zafirlukast therapy.


However, to our knowledge, in newborns there have been no reported cases to date of thrombocytosis induced by enoxaparin.


INTRODUCTION: Although the copperhead (Akistrodon contortrix) is responsible for most Crotaline envenomations in the Carolinas, manifestations and treatment are poorly characterized.


When a GEE is encountered, a rigorous management is required to prevent septic embolism.


Valproate levels remained low because of interactions with phenytoin.


Some of these patients exhibit marked bradycardia (more than 20% deviation from the lowest age-adjusted normal values) while maintaining an arterial blood pressure within an acceptable normal range.


Clinicians should be aware of this potential adverse effect of a widely used drug.


He had developed postchemotherapy complications of possible cellulitis and necrotizing fasciitis that required wound debridement.


This can be prevented by prompt recognition and specific treatment.


This severe illness was likely caused by minocycline, and we speculate that minocycline may have acted as a superantigen, causing lymphocyte over-activation and massive cytokine release.


The relationship between infliximab treatment and lymphoma in Crohn's disease.


Diagnostic workup included repeated MRI scans, PET with an (18)F-amino acid and (18)F-fluorodeoxyglucose (FDG), as well as a brain biopsy.


Bacteriology cultures revealed colonies of aspergillus fumigatus in all bone samples.


Resonance Imaging of LS spine showed an and was managed successfully with antibiotics.


Non-fatal mirtazapine overdose.


He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.


Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.


No direct thrombin inhibitor has a proven advantage; therefore, selection may depend on clinical factors.


The case cited here highlights the need for continued awareness education for physicians who may use ceftriaxone to treat common illnesses such as acute exudative tonsillitis and otitis media in children.


The second patient recovered spontaneously approximately 2.5 hours after administration of brimonidine.


When DSCG was withdrawn, urticaria vanished and the child remained symptom-free.


In this study, we outline the case of a patient with Stenotrophomonas maltophilia bacteremia after living donor liver transplantation, which showed the clinical signs of severe sepsis and was resistant to almost all antibiotics.


In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.


Can roxithromycin and betamethasone induce acute pancreatitis? A case report.


L-Asparaginase is commonly used for induction therapy of acute lymphocytic leukemia of childhood.


Posthypoglycemic hyperglycemia (rebound hyperglycemia) after overdosing of insulin was diagnosed in 6 cats with diabetes mellitus.


Aldosterone antagonists are the mainstay of therapy in patients with hypertension due to primary aldosteronism.


Such a rapid or complete response cannot be achieved by any conventional form of treatment.


We describe the case of a 50-year-old woman with advanced non-small cell lung cancer who developed status epilepticus shortly after receiving cisplatin and gemcitabine chemotherapy.


She was discharged without any neurologic sequela.


Placental changes after thrombolytic therapy have rarely been reported.


BACKGROUND: Pneumocystis jiroveci pneumonia may be a life-threatening opportunistic infection in immunosuppressed solid organ transplant recipients.


Among these 3 cases, all had favorable prognosis despite having jaundiced hepatitis.


Analysis of Naka-Rushton parameters for the ERG scotopic b-wave stimulus-response curves indicated response compression for two patients, as evidenced by a reduction in the maximum response.


We describe a case of infection with Mycobacterium abscessus in a 67-year-old woman receiving infliximab as a component of her therapy for RA.


He had never had any reaction from eating chocolate before and therefore reported this observation to his doctor.


Radiography (with and without contrast medium) and ultrasonography revealed a soft tissue mass in the caudoventral portion of the coelom.


A case of recall pneumonitis induced by gemcitabine is reported.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


We describe a preterm infant with severe idiopathic respiratory distress syndrome (iRDS, hyaline membrane disease) who needed artificial ventilation with high inspiratory pressure, high frequencies, 100% oxygen and developed a symptomatic patent ductus arteriosus (sPDA) in the course of the disease.


Central serous chorioretinopathy complicating systemic corticosteroid treatment.


Noncardiogenic pulmonary edema after transfusion therapy is an infrequent but hazardous complication.


Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.


There were four females, 20 males, with 19 patients under the age of 18 years and five over the age of 18.


Oral enzymatic therapy is the most effective method of treatment for large phytobezoars when endoscopic extraction is not possible.


A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.


The obscure autopsy and neuroleptic malignant syndrome.


Adalimumab in the management of palmoplantar psoriasis.


However, this class of drugs can lead to adverse effects on other organs.


Cessation of D-Pen and the start of corticosteroid therapy were followed by recovery from bicytopenia.


We report a case of a 60-year-old woman affected by squamous lung carcinoma, who developed paroxysmal supraventricular tachycardia during cisplatin and etoposide combination chemotherapy.


We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.


We report on a 14-year-old boy with severe haemophilia A who developed a portal vein thrombosis during continuous infusion of F VIII.


Thrombotic thrombocytopenic purpura induced by trimethoprim-sulfamethoxazole in a Jehovah's Witness.


The natural history of spontaneous coronary artery dissection that persists on angiography after the acute event has not been well characterized.


RESULTS: Both patients experienced a previously unreported side effect--falling backward--associated with bupropion use.


Following administration of the antidote, digoxin immune antigen binding fragments (Fab), SDC monitoring is hampered by assay-related problems because of the presence of Fab in the serum.


CONCLUSIONS: Botulinum toxin injection of the lacrimal gland is an effective palliative treatment for epiphora secondary to canalicular obstruction from docetaxel therapy.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


Acute renal failure with severe tubulointerstitial changes in a patient with minimal change nephrotic syndrome treated with enalapril.


Persistence of the proximal portion of the right umbilical vein is described in a premature infant.


PWO is a common problem encountered with VADs.


A purulent exudate was aspirated from the abscesses under computed tomographic guidance.


Successful treatment of the fungal infection was achieved using ketoconazole.


Four patients with similar clinical and laboratory characteristics to our patient's after the combined use of colchicine and statins have been described in the literature.


Characteristic angiitis was found in the ileum with normal-like mucosa, and it was not necessarily associated with ileal ulcers.


Allopurinol may be an effective treatment for granulomatous reactions to foreign body particles.


RESULTS: A previously healthy 42-year-old woman presented with acute-onset delirium with psychotic features as a consequence of levofloxacin therapy.


We report the clinical outcome of liver, heart, and kidney recipients from a single donor.


It is always good to ask the question, "Will this help my patient live better or longer?" when prescribing a therapy.


Two days' administration of levomepromazine 100 mg led him to a coma for 2 days.


On plain X-ray films and CT scans of the abdomen, pancreatic stones began to be dissolved around 8 months of treatment, and diminished in size and number or disappeared in 21 patients (70%) during the mean follow-up period of 32 months.


We conclude that metamizole use is common and may be underrecognized in immigrant Latino patients.


Prior to abdominal closure, he developed copious pulmonary secretions, hypoxemia, and hypotension.


The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).


While undergoing treatment with albendazole, he developed worsening diarrhea with abdominal pain and fever.


Nimodipine, now widely used for treatment and prevention of cerebrovascular spasm, is regarded as a safe drug.


Twenty-one days after starting antiretroviral treatment, he became increasingly manic.


Delayed neurotoxicity of intraventricular interleukin-2: a case report.


It is usually well tolerated and its application is simple.


Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin.


Some of these patients may have been previously treated with radiotherapy.


None of these patients had had pelvic radiation therapy.


OBJECTIVE: To report a case of significant hepatic and renal failure with the use of argatroban in a patient with heparin-induced thrombocytopenia (HIT) requiring continuous veno-veno hemodialysis (CVVHD).


Foscarnet is used as therapy of cytomegalovirus (CMV) infection in immunosuppressed subjects.


He developed significant ischemic changes in standard 12-lead electrocardiogram, transiently raised cardiac enzymes, reduced left ventricular systolic function, pulmonary edema and pulmonary hemorrhage.


The patient's methemoglobin level was 63%.


Impulse control disorders and pathological gambling in patients with Parkinson disease.


An unusual cause of burn injury: unsupervised use of drugs that contain psoralens.


RESULTS: Extensive squamous metaplasia was found in endometrial glands following progestin therapy.


Sudden cardiac arrest associated with major spasm of three coronary arteries was observed about 10 hours after Taxus stent insertion in a three vessel lesion and was successfully treated by intracoronary glyceryl trinitrate infusion.


Procainamide had no effect upon the defibrillation threshold.


In the three index patients, the QTc failed to shorten with left stellate ganglion blockade, beta-blocker challenge, or stress testing, suggesting an acquired form of the long QT syndrome in these patients with HIV disease.


A man with systemic lupus erythematosus receiving chronic steroid therapy presented with headache, fever and panophthalmitis.


Since elevated cortisol levels in Cushing's disease poses a threat for pancreatitis, there is a possibility that patients with Cushing's disease might be more prone to acute pancreatitis following propofol administration.


A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.


Dose and a hypersensitivity reaction were doubtful factors in these cases.


No explanation for this delay was found, other than the possibility that magnesium sulfate treatment impeded lactogenesis.


Even though anti-inflammatory, analgesic and antipyretic effects of henna have been shown, it may cause severe side-effects in some cases.


Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl.


Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome.


Hepatic failure developed after a routine surgical procedure.


Patients with low or absent thiopurine S-methyltransferase (TPMT) activity, resulting in high 6-thioguanine nucleotide levels, have an increased risk of developing leukopenia.


Temporary suspension of anticoagulant therapy (83% in our study group) to rule out minor surgery, appears to be the most frequent cause of thrombosis.


In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.


Adult respiratory distress syndrome after treatment with pegylated interferon alpha-2a and ribavirin.


However, correction of the hemodynamic parameters did not improve renal function.


Protocols that successfully incorporate platinum agents, despite a platinum hypersensitivity, are clinically relevant.


Acute onset of nephrotic syndrome during interferon-alpha retreatment for chronic active hepatitis C.


When renal function is compromised, careful monitoring of electrolyte levels, daily urine output, and renal function is necessary with mannitol therapy.


Two weeks after stopping the adminsitration of tacrolimus, his urine output improved, and the hemoglobin and serum creatinine normalized.


A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g.


Ventricular free wall rupture remains the most serious complication after acute myocardial infarction.


He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.


We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.


The epivodes of NMS occured under treatment with clozapine, risperidone, and amisulpride.


The patient had suffered two spontaneous left humeral fractures treated with prosthesis replacement just before the initial diagnosis of multiple myeloma.


Four years later, the patient is alive and well with an ejection fraction of 53%.


OBJECTIVE: To describe a case of thrombocytopenia associated with the administration of lansoprazole.


It may induce rapid apoptosis and subsequent tumor lysis syndrome.


The possible relationship with prior and present antiretroviral treatment, and with the most recent literature evidences published in both adults and children with HIV disease are discussed, in order to focus these emerging adverse effects of long-term antiretroviral therapy in the paediatric population, and stimulate further investigation in this field.


The purpose of this study was to heighten awareness of a potentially life-threatening drug interaction in patients with chronic uveitis treated with cyclosporine.


Genetic defects of sertraline demethylation and/or Pglycoprotein binding or concurrent circumstances may explain the onset of rhabdomyolysis in this particular patient.


Reversal of CNS-prophylaxis-related leukoencephalopathy after CSF shunting: case histories of identical twins.


Leukopenia during thiopurine therapy not explained by TPMT deficiency could be induced by parvovirus B19 infection and compels temporal but not permanent cessation of thiopurine therapy.


BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.


METHODS AND RESULTS: Clinical signs of adrenal suppression were observed in the newborn 3 h after birth.


There months following surgery, liver metastases were documented associated with elevated levels of serum androgens.


He was diagnosed with possible serotonin syndrome; his symptoms resolved after clomipramine was stopped but before clozapine was restarted eight days later.


A 58-yr-old male patient with essential thrombocythaemia (ET) developed chronic myeloid leukaemia (CML) after continuous uneventful treatment with hydroxyurea for 18 yr.


Our report suggested that CBDCA hypersensitivity was correlated with the total dose of previously administered platinum agents and that CBDCA should be excluded in patients who have received multiple platinum-based chemotherapy, even in platinum-sensitive cases, because CBDCA hypersensitivity can occur even with low-dose CBDCA administration.


CONCLUSION: It is suggested that antibiotic-induced endotoxemia of a patient with septic endogenous endophthalmitis produced endotoxin-induced uveitis under an upregulation of HLA and endotoxin activated macrophages may release cytokines, followed by fibrin formation and subsequent granuloma.


This case is reported here for documentation because of its rarity.


These differences necessitate close monitoring of hypothyroid patients, counseling these patients about the clinical signs of sub- and supratherapeutic levothyroxine dosages, and prudence when switching patients with stable hypothyroidism to alternative levothyroxine products.


It completely remitted following withdrawal of phenelzine combined with a low dose of haloperidol (1 mg/day) for several days.


Bilateral Acanthamoeba keratitis with late recurrence of the infection in a corneal graft: a case report.


Heparin-induced thrombocytopenia complicated with massive thrombosis of the inferior vena cava after filter placement.


In addition, by far the majority of bleeding complications can be treated effectively.


Decreased cellular Mg content with normal serum Mg level predisposes to digitalis-toxic arrhythmias.


The literature is reviewed, and clinical symptoms, pathophysiology, and treatment options are discussed.


A mere hypoperfusion of the kidney does not seem sufficient to account for all 5 observations: in 3 of them changes in blood pressure did not parallel changes in renal function.


No adverse effects were observed.


Patients typically have generalized lymphadenopathy, fever, weight loss, skin rash, polyclonal hypergammaglobulinemia and autoimmune phenomena, and are susceptible to infections.


The patient has since required a maintenance dose of L-thyroxin.


The mechanism by which these eruptions occur is not completely understood, although there are many interesting theories.


OBJECTIVE: We report an adult case of nasopharyngeal carcinoma treated with radical chemo-radiotherapy, with subsequent development of a histologically proved temporal cavernous haemangioma within the radiation field.


Similar to antiarrhythmic drugs aggravating particular arrhythmias, antiepileptic drugs can paradoxically induce new seizure types or exacerbate existing ones.


Thus, we suggest that a hypercoagulable status possibly created by both the malignancy and cisplatin-based chemotherapy may have played a significant role in the development of the aortic thrombus.


After falling and scraping his left elbow, bacitracin ointment was applied to the wound.


The patient was enrolled in a weight-loss clinic, and his diabetes medications were adjusted.Subsequently, olanzapine was discontinued because of weight gain and uncontrolled diabetes.


The patient died of heart failure complicated by pneumonia.


We describe two patients in whom this conversion occurred in the absence of hypertension or excessive anticoagulation and was substantiated by serial computed tomographic brain scans.


Antibiotic-induced endotoxemia in a patient with endogenous endophthalmitis.


The patient deteriorated to Glasgow Motor Scale score (GMS) 2 and a CT scan showed signs of raised ICP.


The child developed the nephrotic syndrome at the age of 17 months.


Capecitabine is used to treat advanced breast and gastrointestinal malignancies.


This method precisely limits the exposure to methotrexate, allowing a therapeutic effect without complication even in those patients who exhibit methotrexate sensitivity.


Allopurinol hypersensitivity.


Due to discomfort, diplopia and lagophthalmos, the haematoma necessitated suspension of warfarin therapy and a surgical evacuation.


Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.


Detailed postmortem examination of one patient revealed no anatomical abnormalities of the central nervous system.


Osteonecrosis of the jaw is an uncommon consequence of biphosphonate therapy.


Superior sagittal sinus thrombosis in a patient with postdural puncture headache.


Amiodarone induced torsades de pointe.


Development of cavernous haemangioma following radical chemo-radiotherapy for nasopharyngeal carcinoma.


DESIGN: Case report.


Intravenous pulse corticosteroid therapy was given for three days.


A second biopsy after clinical improvement showed resolution of cholestasis but persistence of duct paucity.


Coexistence of hereditary angioedema and Turner's syndrome has not previously been reported and this case highlights the detrimental C1 inhibitor level lowering effect of oestrogen in hereditary angioedema.


Inhibition of the hepatic metabolism of warfarin by 5-FU and levamisole is the postulated mechanism of this drug interaction.


We have used the gastrinoma syndrome to examine the effects of SMS.


A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.


The two patients were finally released in good condition.


The factors which may have predisposed to its development are reviewed.


The patient presented with fulminant microangiopathic hemolytic anemia and thrombocytopenia within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole.


However, dilated cardiomyopathy has not improved in spite of the cessation of interferon treatment.


Pure red cell aplasia (PRCA) due to parvovirus B19 (PVB19) infection after solid organ transplantation has been rarely reported and most of the cases were renal transplant recipients.


After discussion with the patients with regard to the management of this condition and possible complications, five opted for botulinum toxin therapy and five declined further intervention.


He experienced stiffness, myalgias, and classic rippling, which was confirmed on clinical examination.


CASE SUMMARY: A 55-year-old man was taking an extract of C. mukul 300 mg 3 times daily to lower his cholesterol level.


A mechanism of unopposed alpha stimulation as a result of beta-2 receptor blockade is proposed, and a cautious approach to the use of propranolol in these patients is suggested.


Intravenous cytarabine and methotrexate appear to act synergistically to enhance the potential for central nervous system toxicity.


This case emphasizes the importance of making interventions based on individual patient response.


Norethisterone and gestational diabetes.


PURPOSE: We studied a case of vortex keratopathy that was associated with the use of atovaquone.


CASE SUMMARY: An 80-year-old white female, followed up at the Memory Clinic for mild cognitive impairment, had been taking propafenone 900 mg/d for >10 years for paroxysmal atrial fibrillation without adverse effects.


Because steroid-containing regimen may cause reactivation of hepatitis B virus (HBV) and hepatitis may progress to be fulminant after its withdrawal, we administered CHO (CPA, DOX and VCR) therapy and the patient obtained complete response.


We report here two patients who underwent T cell-depleted mismatched-related stem cell transplantation for hematologic malignancies and required aggressive post-transplant immunosuppression for graft-versus host disease (GVHD).


The purpose of this article was to provide a detailed review of the role of TNF-alpha in controlling hepatitis B viral infection and the clinical impact blockade might have on viral control.


Amiodarone was the third drug to induce AVT in this patient; she received 200 mg/day six days per week for six months.


METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.


The patient had successfully completed both induction and consolidation chemotherapy without steroid administration.


We retrospectively reviewed 16 patients with recurrent/metastatic head and neck cancer who received S-1 monotherapy.


Gastric outlet obstruction due to an iatrogenic cause in a neonatal period - report of two cases.


Though prosthetic infection with Brucella spp. is an extremly rare condition (only 1 case each of femur and hip, and 3 cases of knee had been previously reported in the English literature), brucella infection of prosthetic joints should be considered in brucella endemic areas.


The patient eventually had full resolution of her symptoms.


Magnetic resonance imaging findings on day 10 showed periosteal soft tissue changes and mild bone marrow edema of the femora and tibiae.


Nonspecific changes were observed, with probability of drug-induced injury.


Chymopapain--past and present, future?


Umbilical artery catheterization is known to be associated with aortoiliac thrombosis in approximately 1% of newborns in whom catheters are placed.


An epinephrine injection was administered and the boy immediately felt better.


These idiosyncratic reactions may be transient and do not always necessitate drug discontinuation.


Initial cases were associated with anticonvulsants, although other drugs have now been implicated.


We also showed that the drug was inhibitory to fungi in vitro as a vapor, not requiring contact by diffusion through agar or broth.


The AKBR also reflects the efficacy of treatment for cyanide poisoning.


Without any further intervention the patient had 2 separate and prolonged PSA increases and decreases 12-35 months after therapy.


OBJECTIVE: Somatostatin and its analogs have recently been introduced in the treatment of chylous effusions in infants and children following surgery.


Serum testosterone, dihydrotestosterone and estradiol fell to castration levels 4-6 weeks after the initiation of treatment and remained low throughout the study period.


Two patients with extrinsic asthma and coexistent insulin-dependent diabetes mellitus sustained an anaphylactoid reaction after the intravenous administration of 50% solution of dextrose.


Extrapyramidal side effects induced by some selective serotonin reuptake inhibitors (SSRIs), i.e. fluoxetine and sertraline, have been previously reported in patients with depression and obsessive-compulsive disorder (OCD).


Clinical recovery required an average of 42 days and was complete in four of five patients.


Case 2 demonstrated after 40 months on chlorambucil the presence of a balanced translocation, t (1;5) (p36;q31) in 90% of the cells.


Isoniazid associated, painful, bilateral gynaecomastia.


Unusual side-effects due to clobazam: a case report with genetic study of CYP2C19.


New onset of CD may be considered as an immune-mediated injury induced by etanercept.


This finding differs from other common agents, in which 63% of the radiation recall events are reported to manifest as a dermatitis.


An anovulatory patient was treated with human menopausal gonadotropin and human chorionic gonadotropin.


Furthermore, these results also indicated that a low-dosage IV-Ig therapy is effective enough for hemostatic management for programmed surgery.


This report describes the case of a 53-year-old woman with pacemaker pocket infection due to acremonium species.


Mannitol treatment alone did not lower the intraocular pressure after 90 minutes, although improvement was noted four hours after methylprednisolone.


The deposits were bilateral, yellow-white colored, stellate, and mainly peripheral.


These cases also suggest that the occurrence of RLS can cause noncompliance with antipsychotics in psychiatric patients, and thus aggravate their psychotic symptoms.


At least some patients with AL amyloidosis achieve complete remission of their plasma cell dyscrasia, improvement in performance status, and clinical remission of organ-specific disease after this form of treatment.


Although neurotoxicity is a frequent complication of methotrexate therapy, fatal acute neurotoxicity is extremely uncommon, especially in adults.


In this report, we describe a patient receiving lenalidomide in whom dyspnea, fever, hypoxia, and diffuse pulmonary infiltrates developed.


Radiation-induced bilateral optic neuropathy in cancer of the nasopharynx.


Electrolytes must be monitored frequently during foscarnet therapy.


PURPOSE: The purpose of this report is to emphasise the role of the Acute Pain Service in managing local anaesthetic epidural infusions for postoperative pain management, the importance of vigilant monitoring, and to offer some guidelines to using local anaesthetic epidural infusions.


CASES: A 37-year-old man with chronic hepatitis C and a 59-year-old man with chronic myeloid leukemia, both of whom had received IFN therapy, were referred to our outpatient clinic.


Tocolysis was stopped immediately, and the laboratory data improved gradually.


Correction of serum electrolyte imbalance prevents cardiac arrhythmia during amphotericin B administration.


The neuroleptic malignant syndrome (NMS) is a potentially fatal complication of antipsychotic drugs.


After 2 courses of intravenous immunoglobulin (IVIG) therapy, bone marrow erythropoiesis recovered with his hemoglobin level increased to 123 g/L.


Hepatotoxic effects in a child receiving valproate and carnitine.


Eyelid depigmentation following corticosteroid injection for infantile ocular adnexal hemangioma.


MEASUREMENTS: A large intraatrial catheter-tip thrombus (2.5 x 3 cm) was an incidental finding on an echocardiogram done to assess cardiac function.


Heat stroke in schizophrenia during clozapine treatment: rapid recognition and management.


In all 4 patients lymphopenia was observed before the initiation of corticosteroid treatment and low CD4 and CD8 cell counts were evident at the time of PCP.


Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy.


A 73-year-old woman presented with fever and cough 2 weeks after completing the third cycle of fludarabine for chronic lymphocytic leukemia (CLL).


A low dose of cisapride (5 mg b.i.d.) produced rapid relief from nausea elicited by the initiation of treatment with a selective serotonin reuptake inhibitor in eight patients.


We reviewed medical records to identify preoperative, operative, and postoperative similarities and differences in care.


In 1984 alanine aminotransferase presented abnormal levels.


Pharamcokinetic parameters were found to be significantly different from published adult parameters, such as a faster elimination rate, shorter half-life, and increased clearance.


The mechanisms producing ischaemia following intra-arterial injection of drugs of abuse and possible treatment are discussed.


This is the first report of acute kidney injury due to zonisamide-induced DRESS/DIHS.


Understanding this array allows the astute clinician to improve the lives of their patients with PD.


CONCLUSIONS: Chloroquine-resistant vivax malaria is increasingly widespread, and transmission can occur within large tropical population centers.


After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.


Tailored therapy of adult acute leukaemia in Jehovah's Witnesses: unjustified reluctance to treat.


Most patients were also taking concomitant valproic acid.


Eruptive latent metastatic melanomas after initiation of antitumor necrosis factor therapies.


This complication of insulin therapy was common in the past with the use of animal insulins and became less common with the increasing purification of these and the introduction of recombinant human insulin.


This idea should be revised because functional imaging showed that this RLS patient had no dopamine depletion.


PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.


Further post-marketing surveys are required.


Fulminant hepatitis associated with disulfiram.


However, a new episode of neutropenia, with a WBC count of 2.8 x 10(3)/mm3 and ANC of 0.448 x 10(3)/mm3, occurred 11 days after teicoplanin initiation.


Post cardiac surgery diaphragmatic spasm successfully treated with gabapentin.


Hepatobiliary disorders associated with orally administered terbinafine have rarely been reported.


The neonate weighed 884 g and died 1 h after birth.


Finally, clinicians should not extrapolate the results of the Endophthalmitis Vitrectomy Study to the postfiltration surgery endophthalmitis given the differing pathogenesis and unique spectrum of organisms.


The potential for adverse system reactions resulting from topical medications should be considered.


Methotrexate pneumonitis in nonsurgical treatment of ectopic pregnancy.


We also discuss whether screening for DPD deficiency is warranted to identify patients at risk for severe toxicities from 5-FU treatment.


A suspected second episode occurred after subsequent chemotherapy and sargramostim treatment.


However, we successfully treated the patient with the antibiotics trimethoprim-sulfamethoxazole (TMP/SMX) and minocycline hydrochloride (MINO), and performed endotoxin-absorbing therapy using polymyxin B (PMX) to remove the endotoxin from Gram-negative bacillus as well as continuous hemodiafiltration (CHDF) to remove inflammatory cytokines.


48 h after interrupting treatment, she recovered normal neurological status and 500 mg of valacyclovir every 2 days was effective and well tolerated.


A 28-year-old female patient complained of intractable pain in the left arm, shoulder, and back and weakness, numbness, and muscular cramp in the left arm.


There was prompt response of oral ketoconazole.


The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.


It seems likely that these reactions were caused by rifabutin, alone or together with other drugs such as clarithromycin.


After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.


In addition, a partial recovery of the scotopic b-wave full-field ERG was noted 19 years after cessation of treatment.


We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.


It is important that physicians be alerted to this serious, potentially lethal, complication, as it is readily reversible if the disulfiram is discontinued and appropriate supportive measures are taken.


Intravenous valproate has been suggested for the treatment of status epilepticus in part because of its relatively good cardiovascular safety profile.


It draws the clinician's attention to unusual susceptibility to extrapyramidal side effects and suggests that if a child shows this type of susceptibility to one neuroleptic, he/she may react similarly to other neuroleptics as well.


The ototoxicity of quinine can accurately be studied with ultrahigh frequency audiometry (up to 20 kHz).


Fludarabine monophosphate, a purine analogue is used in the treatment of lymphoid malignancies.


METHOD: Report of a case.


Ballistic movements due to ischemic infarcts after intravenous heroin overdose: report of two cases.


His weekly warfarin dose was increased by approximately 5%, and he was given three fecal occult blood cards.


A 26-year-old woman with extra-pulmonary Wegener's granulomatosis was treated with cyclophosphamide for 3.25 years, cumulated dose of 91 g.


Agranulocytosis and granulocytopenia associated with quetiapine.


At the onset of nephrotic syndrome, the patient remained in a hematological remission.


At the time she was taking lithium carbonate 450 mg twice/day.


Angioedema and dysphagia caused by contact allergy to inhaled budesonide.


We report the first case of an acute flare of eosinophilic cystitis in a 51-year-old woman after bladder instillation with dimethyl sulfoxide (DMSO) for presumed interstitial cystitis.


Abrupt, fatal intravascular hemolysis occurred after the third course.


He was treated with clindamycin, gentamicin and underwent surgical debridement, but succumbed to other complications.


Organic affective psychosis associated with the routine use of non-prescription cold preparations.


Proliferation of abnormal bone marrow histiocytes, an undesired effect of granulocyte macrophage-colony-stimulating factor therapy in a patient with Hurler's syndrome undergoing bone marrow transplantation.


Central nervous system (CNS) toxicity other than optic neuropathy is not widely reported.


We describe a first case of keratitis caused by Nocardia exalbida.


Seven days later, she had full-blown, severe hepatitis.


Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.


MAIN OUTCOME MEASURES: The infants were monitored by serial measurements of basal serum cortisol concentrations, responses to the Synacthen stimulation test, measurement of growth and of weight gain, and, in one case, more detailed anthropometric measures of body composition.


We report a case of a patient with mild chronic renal insufficiency who had been taking simvastatin for over a year and developed acute weakness within 3 weeks after the start of treatment with colchicine for acute gouty bursitis.


RESULTS: Expression of SSTR2A and PPAR gamma was identified in TSHoma cells.


Pulsed-field gel electrophoresis (PFGE) was used to determine whether the isolated microorganisms were the same.


A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day).


Thrombolytic therapy with tissue plasminogen activator (tPA) for acute myocardial infarction may result in major bleeding complications such as gastrointestinal or intracranial bleeding.


Steroid creams applied topically to the skin are routinely used in the treatment of many dermatoses.


Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ).


The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) has numerous etiologies, including medical illness, stress, and various pharmacologic agents.


We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide.


A 42-year-old Thai man was administered the combination drugs liponavir/ritonavir and abacavir/lamivudine.


Only 1 case has been described in detail, and this had a fatal outcome.


CASE DESCRIPTION: A 5-year-old sexually intact male cockatiel was examined because of progressive dyspnea of 1 week's duration.


However, there remain questions concerning whether these drugs, especially methimazole (MMI), may be associated with aplasia cutis congenita (ACC) and how best to avoid impairment of fetal thyroid function during their use.


Chronic myelogenous leukemia (CML), hepatitis C, and interferon alpha (IFNalpha) have all been associated with renal dysfunction.


Five days after discharge he was readmitted for similar symptoms, including an 11.8-kg weight gain.


A case of oculogyric crisis induced by metoclopramide is described in this paper.


Abscesses of the pterygopalatine fossa are extremely rare.


Nonsustained polymorphous ventricular tachycardia during amiodarone therapy for atrial fibrillation complicating cardiomyopathy.


Management of cryptococcosis and toxic epidermal necrolysis in a dog.


The case presented here provides some insight into the potential efficacy of certain herbs for relieving mild-to-moderate poison ivy dermatitis.


Fatal lung fibrosis caused by paclitaxel toxicity has not been reported In this report, we describe the case of a 62-year-old woman who received six cycles of paclitaxel and carboplatin as combination chemotherapy for advanced ovarian cancer.


Topiramate is a new anticonvulsant drug recommended for treatment of partial and generalized seizures in children and adults.


It is therefore one of the most serious long-term complications of current cancer treatment and is likely to increase as longer survival rates for the primary tumour are achieved.


Scleroderma in association with the use of bleomycin: a report of 3 cases.


After an initial diagnosis of atypical eating disorder, an upper gastrointestinal study revealed superior mesenteric artery syndrome.


After this episode, she showed the rapid destructive stage of the Rett syndrome, i.e., severe psychomotor retardation with loss of speech, peculiar stereotypic hand movements, autistic behavior and seizures.


The effect of repeated exposure to specific chemicals on the initiation or progression of mycosis fungoides (MF) remains unsettled.


We are concerned that the macular lesion was a retinal toxic effect of gentamicin because of the recent description of similar lesions occurring after the inadvertent intraocular injection of massive doses of this drug.


However, we postulate that a delayed perforation of the bladder might occur due to the cytotoxic effect to the bladder tissue of the instilled drugs.


We present two cases of anaphylaxis under anaesthesia where return of spontaneous circulation was refractory to epinephrine, but occurred following the administration of the alpha-agonist metaraminol.


BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.


Because of life threatening plasma methotrexate (MTX) levels, carboxypeptidase G2 (CPDG2) was administered resulting in a dramatic decrease within 1 hr.


Here we describe a clinical case in which time to diagnosis from the onset of peptic symptoms was delayed more than 10 years, in part reflecting symptom masking by continuous prescription of the PPI omeprazole.


The patient suffered excessive toxicity with low-dose irinotecan although no functional polymorphism in UGT1A1 was identified.


We describe a 12-year-old boy who developed desquamative interstitial pneumonitis and hepatic cirrhosis several years following the onset of ulcerative colitis.


This last test was positive.


This suggests that UGT1A9 poor metabolizer genotype(s) may be a predisposing factor for COMT inhibitor-induced hepatotoxicity.


We postulate that gastritis caused by dexamethasone, mucositis caused by doxorubicin, and the unique anatomic nature of a Meckel diverticulum may have contributed to this extremely unlikely and previously unreported event.


We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).


In all three patients, HDL cholesterol levels returned to normal following drug withdrawal.


We report a case of 48-year-old woman with seizure disorder on divalproex sodium (Depakote) who presented with dyspnea.


We present three cases of fatal hepatic necrosis in patients with epilepsy taking anticonvulsants, in which the terminal illness presented as an unusually severe generalized tonic-clonic seizure with failure to regain consciousness.


We described a very atypical case of a high stage, high grade endometrial cancer associated with tamoxifen in a 64-year-old woman with a past history of breast cancer.


Eventually, both patients were found to have adrenal insufficiency responsible for the fever, which improved after steroid replacement.


Phone followup was attempted.


Video distraction initially inhibited vomiting but the treatment effects were not maintained.


Successful treatment was achieved with partial resection of the posterior mitral valve leaflet and antibiotic therapy.


We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx.


Newborn infants are most vulnerable to the development of thrombosis because of the developing neonatal hemostatic system, perinatal risk factors and different types of medical conditions.


A 74-year-old patient with idiopathic Parkinson's disease was evaluated for unintended sleep episodes that occurred after long-term treatment with 400 mg/day of L-dopa.


Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.


Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).


DISCUSSION: We postulate that the rapid onset of hyperglycemia and the resulting medical sequelae were due to olanzapine.


In all three patients carbamazepine was introduced and gradually increased to a maximum dosage of 25 mg/kg of body weight per day.


We report three cases of severe hypocalcaemia associated with i.v. bisphosphonate treatment in patients with multiple myeloma.


Life-threatening alterations in heart rate after the use of adenosine in atrial flutter.


The viral DNA copy number in whole blood remained positive, however, but was reduced.


In addition, we emphasize the need for informed consent when facing factors that predispose to bleeding (esophageal varices, coagulopathy and thrombocytopenia), possible band ligation before the start of sorafenib, careful clinical monitoring and discontinuation of sorafenib when major bleeding occurs.


Although these eight patients had shown various mental, neurological and gastrointestinal symptoms, as well as skin lesions, the diagnosis of pellagra had not been made clinically.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


Pegylated liposomal doxorubicin (PLD) is a chemotherapeutic agent used in the treatment of solid tumors.


He died from acute leukaemia.


The toxicity and plasma concentrations of ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide were then determined over 24 h after a single 1.6 g/m2 dose of ifosfamide.


CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.


Polymyositis was diagnosed on muscle biopsy.


METHODS: Rituximab (1 mg/0.1 ml) was injected in the vitreous of one eye of three Dutch-belted rabbits.


Six months after the procedure, the patient had an elective angiogram, where we discovered a new severe occlusion distally to the former stent; a second PES was implanted.


CASE REPORT: A six-year-old boy with transfusion-dependent beta-thalassaemia developed a unilateral hearing loss shortly after commencing desferrioxamine therapy.


Tracheal mucociliary transport velocity (MCTV) was measured by timing the movement of 4 microL of mucus across the trachea.


A minimum peripheral dose of 36 Gy HDR was administered in 12 fractions (twice a day) at 3 Gy per fraction for a period of 3 days.


Blood GHB concentrations in the range 156-260 mg/L have been reported to induce moderately sound sleep.


We discuss our observations in the cases of two patients with acyclovir neurotoxicity and review the findings of all previous reports in the English language literature.


The patient is healthy 16 months after discontinuation of fluconazole.


Six months following cessation of therapy, the ERG was still abnormal for one patient, but continued improvement was evident at 25 months; for the second patient, the ERG was normal at one year.


Early blindness and coma during intrathecal chemotherapy for meningeal carcinomatosis.


After clonidine was initiated, the patient's spasticity improved.


Calculation of this volume from peak and trough levels showed an increase of the volume of distribution during and after chemotherapy.


The patient exhibited clinical regression and functional improvement.


Endodontic treatment, when possible, rather than extraction is the treatment of choice in patients suffering from such a disease.


Disseminated encephalomyelitis in adults.


This article describes the conservative follow-up of a patient with epidural abscess and diskitis following instrumented posterior lumbar interbody fusion using a metal cage without surgical intervention.


These signs resolved 24-48 h after cyclosporin and ganciclovir were discontinued.


A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.


An alteration in CNS serotonin activity is hypothesized to be the underlying mechanism for several myoclonic syndromes.


Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.


Tumour vaccine associated lymphadenopathy and false positive positron emission tomography scan changes.


Thrombin is highly effective for stopping intractable arterial hemorrhage during stereotactic brain biopsy; however, it is a vasospastic agent and may have been responsible for the cerebral infarctions in one patient.


Electrocardiographic findings and laboratory data indicated a diagnosis of acute myocardial infarction due to the L-thyroxine therapy.


We describe a patient who developed significant deterioration in her conscious level due to iatrogenic gabapentin overdose.


We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association.


Their criticisms also differed from a third criticism contained in the article as well as the protocol being advocated in the article, thus contravening the claim that there is one prescribed protocol which must be followed.


The disorder recurred during treatment with paclitaxel.


DISCUSSION: NMS is a rare but potentially fatal reaction associated with neuroleptic drugs.


As with previously reported cases, the condition presents in young women and results in edema of the palms with visibly prominent eccrine ducts after brief exposure to water.


The cause is believed to be either a hypersensitivity reaction or a toxic dose-related suppression of white blood cell precursors.


A 45-year-old woman with steroid-dependent Crohn's colitis, successfully managed with maintenance infliximab infusions and methotrexate, developed a lupus-like syndrome eight months after her initial infusion.


Both patients failed to improve after discontinuation of the offending agent, and they responded poorly to corticosteroids.


Most of the patients had acute leukemia (AL) or related disorders and had received chemotherapy treatment.


Combined therapy of advanced prostatic carcinoma with estramustine and prednimustine.


Fulminant metoclopramide induced neuroleptic malignant syndrome rapidly responsive to intravenous dantrolene.


We report 3 cases of HIV-1 infected patients who experienced symptomatic angiolipomas shortly after starting antiretroviral therapy including the protease inhibitor indinavir.


Few studies have addressed the impact of the new neuraminidase inhibitors in the prognosis of influenza after BMT.


Intractable hypomagnesemia was also a prominent feature.


The possible pathogenic mechanisms leading to this adverse reaction in this patient are also discussed, and pathophysiologic hypotheses are formulated.


Only minor complications have been reported previously.


The in vivo occurrence of such giant forms is rare, and when observed histologically may result in an erroneous diagnosis or a diagnosis of multiple mycotic organisms.


With the first cyclosporine dose, the patient complained of leg pain that was most severe during the cyclosporine infusion.


BACKGROUND: Several genetic polymorphisms increase the risk for venous thrombembolism (VTE).


It is important to always review the medications the patient is taking and consider them as etiological culprits in any new symptom complex.


The patient's response to the combination of clonazepam and baclofen suggests that the pathophysiology of the "painful legs and moving toes" may be linked to impairment of spinal serotonergic and GABA functions.


New onset rapid cycling bipolar disorder in an 87 year old woman.


For the treatment of visual loss, differential diagnosis is important between infection and adverse effect of anti-tuberculous drugs.


Our patient was a 72-year-old man with advanced Parkinson's disease (PD) who received levodopa and anti-cholinergic drugs and whose head had become almost completely bald.


In addition, an immediate erythematous macule was observed on the photopatch test site of mequitazine directly after UV exposure which was similar to the immediate erythema noted in chlorpromazine photoallergy.


These cases indicate that sulpiride can cause tardive dyskinesia and that this drug should be administered with caution.


CONCLUSION: We believe this to be the first reported case of rhGH-induced hypercalcemia in an HIV-infected patient.


When a CPS perforates the transverse foramen, even if no apparent VA injury occurs during the operation, the surgeon must take care not to risk cerebral infarction because of an embolism.


He also experienced improvement in his pain control.


According to clinical impression some patients showed an improved goal orientation and self-control which could be effects worth to be followed up.


Titers for Epstein-Barr virus, hepatitis B, toxoplasmosis; and cytomegalovirus were all negative.


INTRODUCTION: Pamidronate disodium, a bone resorption inhibitor through osteoclast mediation, has been used to treat chronic hypercalcemia secondary to malignancy and chronic renal failure.


We encountered 2 patients with a psychiatric disorder (depression in one and catatonia in one) accompanied by motor inhibition that was complicated by pulmonary embolism (PE).


PURPOSE: The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin.


Flutamide withdrawal syndrome is characterized by a decrease in prostate-specific antigen (PSA) after flutamide withdrawal in a subset of patients with progressing metastatic carcinoma of the prostate.


Both infants continued on medical therapy until they reached 1 month of age.


A second episode of jaundice followed the intravaginal administration of a mixture of furazolidone and nifuroxime.


Further study to confirm this significant finding and to determine if the long term prognosis of BP can be altered by the drug, is required.


We report the first case of a patient in a promethazine-induced coma responding to treatment with flumazenil.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


Clinical and pharmacological aspects of accidental triamcinolone acetonide overdosage: a case study.


We concluded that an adequate dose of steroids can be the first line of therapy for PRCA after ABO-mismatched allogeneic stem cell transplantation.


Fetal exposure to anticonvulsant drugs.


We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide.


The combination therapy of interferon alpha and ribavirin was given to a 50-year-old female with CHC who had not responded to a previous treatment by interferon alpha.


With the increasing use of these antimitotic agents, great vigilance should be exercised with regard to renal function and haemolytic status.


Cholelithiasis in turn enhances the effects of cyclosporin on increased platelet aggregation.


OBJECTIVE: To report teicoplanin-related neutropenia that developed after an episode of neutropenia induced by vancomycin therapy.


The incidence and clinical features of allergic contact and/or photocontact dermatitis due to psoralens were examined in 371 patients with psoriasis treated with topical PUVA.


Of note, Compositae dermatitis has been shown to have a higher prevalence in children with atopic dermatitis, so it is important for physicians to be aware of the potential allergens (like bisabolol) in products they are recommending as first line treatments.


On the next day he died, probably as a result of heart failure.


Cisplatin toxicity on cardiac electrical activity is discussed.


Reversal of intractable acute severe asthma by first-trimester termination of pregnancy.


Indeed, the superiority of the combination of interferon alfa and ribavirin in terms of antiviral action is corroborated by the enhancement of a Th1-type immune reaction by this combination.


While most physicians are aware of heparin-induced thrombocytopenia and skin necrosis, the association of heparin and hyperkalemia is less well recognized.


This is a case report of possible association of methylphenidate and enuresis in an 11-year-old boy with attention deficit hyperactivity disorder.


The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.


Improvement in the level of arterial blood gases and pulmonary diffusing capacity occurred after discontinuation of methotrexate therapy.


We report on two cases in which mother-infant PIVKA concentrations were measured at birth after chronic anticonvulsant therapy during pregnancy.


This prompted us to suspect that ddI might be responsible for fulminant hepatitis in all three AIDS patients.


Four months later there were no cells in the anterior chamber and the vitreous was clear.


However, delayed presentation of flap compromise is an ominous predictor of flap loss.


There have been more than 20 observations of the appearance or aggravation of this granulomatosis with interferon alfa and more recently with the combination of interferon alfa plus ribavirin.


From these data, acute generalized dystonia with brainstem and thalamic lesions may occur in WD patients after an initial d-penicillamine therapy.


Improvement in her condition was evident 6 months after discontinuing amiodarone.


Toxicity, pharmacokinetics, and in vitro hemodialysis clearance of ifosfamide and metabolites in an anephric pediatric patient with Wilms' tumor.


Discontinuation of acetazolamide produced an immediate threefold drop in the level of urinary calcium excretion and a slight rise in tubular reabsorption of phosphate, with no dectectable change in serum calcium or phosphate concentrations.


Pulmonary thromboembolism (PTE) in leukemic children undergoing intensive chemotherapy should be promptly recognized so that specific therapy can be started.


The case of a 19-year-old woman with insulin-dependent diabetes and regular and NPH insulin hypersensitivity is presented.


She was commenced on antiretroviral therapy.


Another patient died form an overdose due to misunderstanding of the prescribed dosage given elsewhere.


One patient developed severe hyponatremia with serum Na+ of 108 mEq/L when hydrochlorothiazide was given to control hypertension.


Videopolysomnographic and pharmacokinetic studies with monitoring of plasma levodopa levels demonstrated marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia.


After having received gemcitabine on day 1 of the second course, the patient developed dry cough, subfebrile temperatures and dyspnea within 48 h.


Clinical presentation in each case included generalized malaise with fever, signs of meningeal inflammation and focal neurological signs at the spinal level.


We report on two AIDS cases with long lasting bacteremia due to MAC under this regimen.


Hepatitis following cimetidine administration.


Acute pancreatitis is a rarely reported adverse effect.


Mediastinal extravasation of doxorubicin.


To evaluate whether racial factors may be involved in the development of ART-induced lipodystrophy and/or lipid serum abnormalities, we carried-out a case-control study on all 23 consecutive anti-HIV-positive sub-Saharan black African patients observed from September 20fc01 to December 2001 ('Cases') and 23 Caucasian 'Controls' pair-matched for sex, age (+/-5 years), number of CD4 cells (+/-100 cells), clinical stage of HIV infection, overall duration (+/-3 months) of anti-retroviral treatment and type and duration (+/-3 months) of the last anti-retroviral regimen.


ECG and thallium-201 scintigram.


The presence of a lymphocyte alveolitis with a predominance of CD4+ T cells in 3 RA patients and CD8+ T cells with a concomitant increase in neutrophils in another case suggests that immunologically mediated reactions may be one damage mechanism in MTX-induced pneumonitis.


MRI showed increased T(2) signal intensity predominant in the posterior regions of the brain suggestive of PRES.


This paper argues for an increased recognition of chronically recurrent and tardive OGC.


After induction of general anesthesia and administration of a standard dose of intravenous esmolol hydrochloride, her cardiac rhythm progressed to asystole.


A computed tomography scan of the abdomen was helpful in elucidating the diagnosis, and surgical splenectomy resulted in a good patient outcome, though the period of hypotension had increased the extent of myocardial necrosis.


Further study is necessary to ensure that spinal vascular injuries can be kept to an acceptably rare level.


Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.


Symptoms resolved within 2 days, and she continued venlafaxine with no further adverse effects.


We describe 4 typical cases from the major fields of rheumatology.


Conservative treatment and hydration were carried out.


Rosiglitazone was discontinued and the edema resolved.


We describe the case of a 50-year-old woman with advanced non-small cell lung cancer who developed status epilepticus shortly after receiving cisplatin and gemcitabine chemotherapy.


Histamine poisoning on ingestion of tuna fish.


Life-threatening anaphylactoid reaction to amifostine used with concurrent chemoradiotherapy for nasopharyngeal cancer in a patient with dermatomyositis: a case report with literature review.


A transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials in quinine toxicity, to our knowledge, have not been previously reported.


Mianserin (15 mg/day at 21.00 h) was discontinued and then reinstituted (off-on-off-on design).


Once extensive microbiological studies proved negative, corticosteroids were given and a complete remission of clinical and radiological abnormalities was achieved.


Renin levels should be determined in all hypertensive children and their hypertensive parents.


One patient had to discontinue GBP.


In each of the three reported patients, alteration of eyelid appearance with deepening of the lid sulcus was evident as the result of topical bimatoprost therapy.


Cyclosporine-induced pain syndrome in a child undergoing hematopoietic stem cell transplant.


We describe a patient with acute lymphocytic leukemia (ALL) who developed visceral varicella-zoster virus (VZV) infection following cord blood stem cell transplantation (CBSCT) and was successfully treated with intravenous acyclovir (ACV).


OBJECTIVE: To report a case of rapidly occurring hyperglycemia that occurred in a geriatric patient 3 days after treatment with olanzapine.


The anterior chamber deposits still remain.


All 43 participants with exclusively SCs reported increased sensitivity to one or several odors, with no participants reporting decreased sensitivity.


Furthermore, our finding that large numbers of PDCs infiltrate psoriatic skin suggests a role of lesional PDCs as type I interferon-producing targets for the TLR7 agonist imiquimod.


BACKGROUND: Amiodarone is a benzofuran derivative used to treat cardiac arrhythmias.


The parameters of oxygen metabolism in a patient with cyanide poisoning who was admitted in a coma with seizures was monitored.


Paroxysmal hemicrania responding to topiramate.


There are few reports in the literature of hypoglycemia with concurrent administration of an oral hyperglycemic agent and a fluoroquinolone antibiotic.


Stenotrophomonas maltophilia bacteremia after living donor liver transplantation: Report of a case.


Four cases of pediatric acne rosacea associated with the use of topical fluorinated glucocorticosteroids are described.


The serum creatinine level gradually declined over 2 weeks, and the patient was discharged home with a serum creatinine level of 1.6 mg/dL.


Further work to define doses, schedules, and optimal drug is needed since this approach to steroid use appears effective and relatively nontoxic.


For all patients serum calcium concentrations correlated significantly with serum lithium concentrations.


We report such a series of patients who had transient asymptomatic bradycardia after being treated with continuous infusion 5-FU.


A more likely cause of the inspiratory obstruction appeared to be forward bending of the neck combined with mouth-clenching spasms.


Quinapril is an angiotensin-converting enzyme inhibitor (ACE-inhibitor) and overdose can lead to prolonged hypotension and, less frequently, transient renal impairment.


Nocardiosis is a life-threatening infection, particularly among immunocompromised patients, which usually affects lungs, skin and central nervous system.


We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx.


Delayed-onset multifocal keratitis is a rare complication of LASIK.


Guanidine treatment had a beneficial effect, whereas administration of antitoxin in the late and benign form was not effective.


A prolonged and clinically useful delay in the recurrence of hypertension following withdrawal of the drug was also observed.


Antiepileptic drug hypersensitivity syndrome consists of fever, rash, and internal organ involvement and usually occurs within the first 2 months of initiation of therapy.


This report describes a case of acute compromise of renal function associated with hypotension in a 7-year-old boy treated with the ACE inhibitor lisinopril and the ARB losartan.


Most patients have involvement of the right heart.


We reevaluated his cardiac parameters.


Serotonin-Dopamine Antagonist (SDA) should be proscribed with care became of this rare yet serious complication, especially in cases with previous history of priapism following the use of psychotropic drugs.


Five patients have been weaned from all steroid treatment, and eight have required continued pulses at one- or two-week intervals as outpatients to maintain control.


Although an association between exposure to bleomycin and the development of scleroderma has been suspected, few cases are reported.


This child with acute lymphoblastic leukemia underwent a period of severe refractory lactic acidosis (pH between 6.81 and 7.00 and a serum lactate level up to 38 mmol/liter) leading to cardiac arrest.


Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.


Initiation of posaconazole led to clinical improvement until the patient's demise from bacteremic vancomycin-resistant enterococcal peritonitis.


In conclusion, telmisartan was effective and well tolerated for the control of hypertension in this case and improved sensitivity to insulin.


Pharmacologic doses of vitamin D cannot be recommended for any form of osteoporosis.


After other potential causes of liver toxicity were excluded, TMP-SMX was determined to be the cause of his acute liver toxicity.


Rapid detection of causative pathogen of peritonitis using in-situ hybridization in a patient with continuous ambulatory peritoneal dialysis.


CONCLUSION: Copperhead bites typically result in mild to moderate envenomation due to local tissue effects.


Therefore, we emphasize the importance of treatment to prevent tumor flare during LH-RH analogue therapy.


Despite reduction in immunosuppression, 30%-40% of recipients progress to allograft loss.


Data are presented to show that atopic cataracts and corticosteroids.


Teratogenic effects in a case of maternal treatment for acute myelocytic leukaemia--neonatal and infantile course.


Supralethal magnesemia with patient survival.


The data show a strong influence of cortisol on total sleep time and slow wave sleep (SWS) as well as rapid eye movement (REM) sleep.


However, in rare instances, hemorrhagic pancreatitis or necrosis may occur.


The self-administered therapy resulted in a severe cell-mediated immunodeficiency (as expressed by a nadir CD4 lymphocyte count of 2 cells/muL).


Within 1-6 h of apparently successful thrombolytic therapy for AMI, these three patients experienced sudden and profound bradycardia and hypotension and could not be resuscitated.


Aplastic anemia and agranulocytosis in patients using methazolamide for glaucoma.


General practitioners now have a wider range of effective hypoglycaemic agents from which to choose.


In patient 1 with massive pulmonary thromboembolism, transesophageal ultrasound revealed large right atrial thrombus entrapped in a patent foramen ovale.


Administration of high-dose intrathecal methotrexate may not lead to symptoms, as was the case in our patient.


Linear IgA bullous dermatosis has a much lower prevalence of histological small bowel abnormalities, and lesions are not known to respond to gluten restriction.


RESULTS: Central macular thickness decreased from 511 to 376 microm at month 4 in the treated eye and remained within 10% of this value during follow-up.


Plasmodium falciparum with a parasitemia of 70% was detected in the peripheral smear.


Visceral herpesvirus infections in leukemic patients receiving cytarabine.


This complication has not previously been described in association with vasopressin infusion into peripheral veins.


CONCLUSION: Massive subchorionic hematomas may be observed in patients after thrombolytic therapy.


Because of her severe symptoms, mifepristone was administered for a period of 19 days.


Ifosfamide is a known nephrotoxic drug with demonstrated tubulopathies.


METHODS: Retrospective case series of six eyes of three patients that developed Acanthamoeba keratitis with Synergeyes hybrid contact lens wear.


Evans syndrome refers to a hematological autoimmune disorder with autoimmune hemolytic anemia accompanied by immune thrombocytopenia.


However, its efficacy in preventing invasive aspergillosis could not be demonstrated.


Recurrent unilateral, throbbing, frontal headaches should be referred to as facial migraine.


Implications for its drug management are discussed.


This implies that TNFalpha may play an important role in the development of this condition.


To our knowledge, this is the first report of t-MDS associated with ATL.


The nephrotic syndrome responded again to withdrawal of lithium and institution of steroid therapy.


A 10.5-year-old, castrated male shih tzu was presented for evaluation of weakness, pica, and pallor of the mucous membranes.


Recent reports have shown trinucleotide repeat expansions in the spinocerebellar ataxia 2 (SCA2) gene in patients with levodopa-responsive parkinsonism.


We report a cae of paranoid psychosis following use of a decongestant containing PPA and summarize the case report literature of psychiatric adverse effects to PPA in which doses were known and stated to be within recommended guidelines.


It is important for both the general and cardiac anesthesiologist to understand the effects of thrombolysis on hemostasis and myocardial function, since these patients can present for emergent surgery in the cardiac or general operating theater.


This profile should trigger a "red flag" as to the possibility of phenobarbital behavioral side effects or exacerbation of preexisting maladaptive behaviors.


It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week sulphasalazine syndrome", a rare, but often fatal, immunoallergic reaction to sulphasalazine.


We report the case of a 33-year-old man who presented with a large B-cell non Hodgkin's lymphoma presenting as acute pancreatitis.


Follow-up magnetic resonance imaging 2 weeks later showed complete resolution of the abnormalities.


We report here a 26-year-old female with diffuse large B-cell lymphoma who died of severe pulmonary fibrosis 81 days after the administration of high-dose BCNU (600 mg/m2).


If detected and diagnosed in a timely fashion, it can be treated and should resolve with minimal sequelae.


Sepsis, viral hepatitis, and metabolic liver disease were excluded.


The risk of developing sAML has been estimated to be between 2% and 10%, depending upon the type, duration and dosage of previous therapy (Michels et al, 1985; Shulman, 1993; Robinson & Mertens, 1993; Ballen & Antin, 1993).


Hypersensitivity pneumonitis-like syndrome associated with the use of lenalidomide.


A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone.


Definite regression of the tumors was observed.


At that time anti-tuberculous agents were also being administered for presumed tuberculosis.


The elevated left ventricular end-diastolic pressure causes the left atrial overload which could be at risk of atrial fibrillation in patients with HCM.


Combining methylephedrine and Chinese herbal drugs might carry a risk of stroke.


Serial electroencephalograms were obtained to evaluate CHL central nervous toxicity, before, during and after treatment with this agent.


They represented a typical picture of NE: two of them died because of septic shock; five patients had subileus with irritation of the peritoneum; and one had hepatosplenic abscesses confirmed 6 months later by post-mortem examination.


The authors describe three families in whom the occurrence of FVS in all the siblings strongly suggests hereditary susceptibility to valproic acid-induced adverse outcome.


Although the role of antipsychotics in this situation is speculative, development of rhabdomyolysis related to hyponatremia and/or its correction should not be underestimated and should be assessed thoroughly.


After a two-month interruption of interferon administration, natural interferon alpha was given but followed by another episode of the same neurological manifestations.


Mesalamine may cause hypersensitivity pneumonitis in patients with Crohn's disease.


Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature.


Early asymptomatic recurrence of cervical artery dissection: three cases.


Kaposi's sarcoma in a patient treated with imatinib mesylate for chronic myeloid leukemia.


At autopsy he was found to have multiple hepatocellular neoplasms.


Facial soft tissue augmentation has been performed using different materials.


Atypical endometriosis may act as a precancerous lesion in the process of tamoxifen-induced malignant transformation of endometriosis.


A few reports have appeared concerning switching from clozapine to other antipsychotics for treatment-refractory schizophrenia.


As the list of FMF-associated MEFV mutations is expanded, and/or new sequencing technologies permit more rapid screening, the value and interpretation of genetic testing for FMF will become more straightforward.


After taking cholestyramine II sachets twice daily for two months she presented with lethargy, confusion and drowsiness.


The rationale of suggesting N-AC and IVIG for the treatment of this syndrome relies on the theoretical synergistic effects of the two agents.


The glial abnormality, the most striking feature in the present case, strongly suggests toxic and metabolic disturbances.


Mean time between initiation of gemcitabine therapy and onset of HUS was 7.4 +/- 3.5 months, or 21.9 +/- 10.9 doses of gemcitabine.


Reconciling theory and practice.


Captopril-related (and -induced?) asthma.


IV propranolol was used as the initial treatment for his hyperadrenergic state, resulting in a decrease in heart rate but a paroxsymal increase in blood pressure.


A 75-year-old man developed bilateral lower leg edema 6 months after switching from troglitazone to pioglitazone.


She received an accidental 450-mg bolus injection of morphine intrathecally and developed hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure.


Symptoms and signs of augmentation were related to low plasma levodopa levels, abating 75 minutes after oral levodopa administration and reappearing after 3 hours, closely mirroring the rapid rise and fall of plasma levodopa concentration.


Pseudomonas infections in children with human immunodeficiency virus infection.


Neither infant developed hemorrhage of prematurity as confirmed on cranial ultrasonography.


Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.


The dose-limiting toxicity of KW-2149 is pulmonary toxicity.


Recovery from the side effects was complete 4 months after the last 5-FU treatment.


However, in order to avoid neuropathic side effects, patients under thalidomide therapy should be monitored every 6 months with nerve conduction studies while taking the drug.


Dilatation by a balloon-tipped catheter produced an immediate and sustained reversal of the arteriospasm, together with a dramatic relief of symptoms and signs.


During dose-finding studies for intravenous proton pump inhibitors omeprazole and pantoprazole, three of six young female volunteers receiving omeprazole and two young female volunteers receiving pantoprazole developed peripheral edema within 8 hr when high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid.


The patient was subicteric at the time.


We also strongly draw the attention to the main preventive procedure against invasive fungal infection that is the correct management of antidiabetic therapy that prevents the predisposing temporary neutrophils activity deficit, contributing to a better survival rate of diabetic children.


The concentrations of olanzapine measured in this case were as follows (mg/L or mg/kg): 0.40 (heart blood), 0.27 (carotid blood), 0.35 (urine), 0.61 (liver), negative (cerebrospinal fluid), 0.33 mg in 50 ml (gastric contents).


Mycophenolate mofetil (MMF) is an immunosuppressive drug used in renal transplantation, lupus nephritis and pemphigus vulgaris patients.


This case demonstrates the association of selective IgA deficiency with remission in rheumatoid arthritis induced by fenclofenac as well as aurothiomalate and sulphasalazine.


The infiltrate resolved in response to topical voriconazole, natamycin, and oral voriconazole.


Sexual dysfunction secondary to antidepressant drugs is an under-recognized clinical problem, and likely an important factor in noncompliance with treatment.


Steroid diabetes in children with Crohn disease.


Hydatid disease: the alveolar variety in Australia.


Recurrent septicemia with lethal outcome during and after cyclosporine therapy in severe ulcerative colitis.


Mirtazapine treatment in a subject with autistic disorder and fetishism.


Drug-induced gingival enlargement: biofilm control and surgical therapy with gallium-aluminum-arsenide (GaAlAs) diode laser-A 2-year follow-up.


A case report.


To our knowledge, this is the first case of griseofulvin-exacerbated lupus in which nephrotic syndrome has been observed.


Dorzolamide-induced choroidal detachment in a surgically untreated eye.


Swab of punctured vesicles demonstrated HSV type II by polymerase chain reaction.


Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).


OBJECTIVE: To present a case of neonatal adrenal suppression due to the use of high-dose methylprednisolone in late pregnancy of a woman with Crohn's disease.


The endemic nature of the finding in such a short period of time is outstanding.


Toxic epidermal necrolysis in early infancy.


A cause-effect relationship to capecitabine was suggested due to resolution of headache with capecitabine withdrawal and reappearance with capecitabine rechallenge.


Tacrolimus (FK-506) is an important immunosuppressive agent most often given for maintenance immunosuppression to prevent acute cellular organ rejection.


Although dasatinib is a generally well-tolerated drug in the treatment of Philadelphia chromosome positive hematopoetic malignancies, pleural effusions have been frequently noted and have been reported in up to 35% of patients (Sahn SA.


Type I second-degree AV block (Mobitz type I, Wenckebach AV block) during ritodrine therapy for preterm labor.


She subsequently developed Shewanella spp. bacteraemia without any clinical source of infection.


Magnetic resonance imaging appearance of the shoulder after subacromial injection with corticosteroids can mimic a rotator cuff tear.


A rare complication of trigeminal nerve stimulation during radiofrequency thermocoagulation: sudden ST segment elevation.


Interferon alfa acts by stimulating the T-helper (Th) 1 immune response.


This case report refers to a patient with PLEDs whose EEGs did not change while on steady levels of phenytoin and phenobarbital, but showed a complete disappearance of these discharges when felbamate was used.


Recurrent neutrophilic eccrine hidradenitis.


Adult respiratory distress syndrome as a severe immune reconstitution disease following the commencement of highly active antiretroviral therapy.


All patients had biopsy findings or cultural evidence of the progression of their fungal infection while being treated with conventional amphotericin B.


Therapy must be installed immediately, before additional investigations, and should be continued even when initial neuroimaging is negative.


Mycophenolate mofetil in the therapy of severe myasthenia gravis.


The use of rituximab has been uncommonly associated with delayed pulmonary toxicity.


Very few cases have been described in detail due to the low incidence of this complication.


While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.