We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.


She developed congestive heart failure, and hemodialysis was initiated.


Following discontinuation of clozapine, she was rechallenged and again was observed to have seizures.


Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.


Both were alcoholic, malnourished and presented with radiologically widespread, smear-positive disease and lymphocytopenia.


The global spreading of chloroquine-resistant falciparum malaria brings about an increasing use of quinine.


In contrast, after the last course of chemotherapy, which did not include M-CSF, urinary protein excretion was not enhanced.


We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.


Experience with the use of cytotoxic drugs in the first trimester of pregnancy is limited.


The patient died suddenly, and the autopsy revealed pulmonary embolism originating from the deep vein thrombosis caused by the compression of common iliac vein by the tumor.


In early-recognized, subacute cases a surgical intervention using patches can be lifesaving.


Naratriptan was extremely well tolerated, with no cardiovascular adverse events reported or observed.


Clinicians should be cognizant of this possibility and consider a diagnosis of HDAs in patients with ongoing thrombosis who are receiving heparin therapy.


Serial radiographic observation over two months.


Safety and efficacy of S-1 chemotherapy in recurrent/metastatic head and neck cancer.


On this regime, together with supportive psychotherapy, she experienced a sense of emotional well-being, exhibited a good level of functioning and maintained a safe body weight.


Colonic necrosis is known as a rare complication following the administration of Kayexalate (sodium polystryrene sulfonate) in sorbitol.


A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan.


She was subsequently admitted to hospital and was diagnosed as having nephrotic syndrome.


We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS.


However, the patient became steroid-dependent and experienced recurrent optic neuritis during multiple attempts at tapering the steroids.


A platelet autoantibody could not be detected by a radioactive platelet antiglobulin test, but autologous platelet survival data indicated a compensated thrombolytic state in the recovery period.


We describe a Caucasian child who initially presented with clinical and histopathologic features consistent with inflammatory bowel disease, for whom additional investigations led to the diagnosis of severe chronic active Epstein-Barr virus infection.


These cases were chosen for study because they were all deaths as a result of suicidal ingestion of drugs in which quetiapine was considered a significant factor.


Despite the widespread use of beta-sympathomimetic agents for preterm labour there appears to be a limited appreciation of the need for cardiovascular monitoring in the mother.


Four weeks later, a coronary arteriogram showed only minimal luminal irregularities at the original site of occlusion, where significant reduction in diameter could be induced by ergonovine maleate.


The patient was admitted to the emergency department of a local hospital within two days due to ongoing headache, elevated temperature, and nuchal rigidity, symptoms suggestive of meningitis.


The diagnosis was made on the basis of inflammatory changes in the cerebral spinal fluid and localization of the abscess by means of computer and magnetic resonance tomography.


Combined thrombolytic therapy for prosthetic mitral valve thrombosis.


The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.


CONCLUSION: This side effect, apparently unique to bupropion among antidepressants, may be mediated through dopaminergic effects in the basal ganglia.


Atypical antipsychotics have reduced liability for inducing tardive dystonia and show antidystonic properties in patients with pre-existing tardive dystonia.


A difference in chemical structure between these two drugs, particularly of a sulfur moiety, may help explain why the drug-induced disease did not recur.


Nonopioid analgesics did not relieve her pain, and she was unable to walk without the aid of a walker.


Posttransplant lymphoproliferative disorder of the nasopharynx.


There is no known effective therapy for PEComa, and the molecular pathophysiology of aberrant mTOR signaling provided us with a scientific rationale to target this pathway therapeutically.


Possible explanations of this ocular effect are offered: pharmacokinetic interference on the drugs used in glaucoma treatment, in vivo action on the muscarinic receptor, indirect effect via dopaminergic receptors, or direct effect on the ocular sympathetic postganglionic neurones.


Both patients completely recovered after transient pancytopenia, but showed severe and intermediate neutropenia (0.216 and 0.768 x 10(9)/l, respectively) at the nadirs of aplastic crises.


Twenty-one days of magnesium sulfate tocolysis were performed on a 28-year-old woman because of preterm labor at 31 weeks gestation.


Cardiac function and symptoms recovered completely.


Glucocorticoids in early rheumatoid arthritis.


It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.


Direct immunofluorescence revealed staining at the dermal-epidermal junction and around blood vessels with IgG in the first case and with IgG, IgA, and fibrin in the second case.


Graft-versus-host disease was seen only in 41% of the bone marrow recipients.


A physical and/or chemical in vitro compatibility of 5-FU and calcium folinic acid, without validated clinical data is not sufficient to use this mixture in routine clinical practice.


CLINICAL FEATURES: The patient was a 22-yr-old obese man with metastatic testicular carcinoma who underwent a left-sided thoracoabdominal retroperitoneal tumour resection.


Two cases of polymorphic ventricular tachycardia induced by the administration of verapamil against paroxysmal supraventricular tachycardia.


CASE: We herein report the case of a 67-year-old woman with a history of breast cancer, taking tamoxifen citrate 20 mg/day for 4 years, who underwent an operation for left ovarian tumor.


The symptoms started when the immune status reached normal CD4 T cell levels, in response to antiviral tritherapy.


Imaging confirmed this excellent response.


A 65-year-old female patient presented with jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat, 1 week after the fourth dose of adalimumab.


Chemotherapy was stopped and systemic application of prednisolone was initiated.


Hepatotoxicity seen with erlotinib, a small molecule tyrosine kinase inhibitor to EGFR, is usually transient with mild elevation of transaminases.


In each case, brief periods (5 to 20 seconds) of rapid atrial pacing were effective in terminating the supraventricular tachycardia and resulted in a return to normal sinus rhythm.


This encouraging result suggests that BMT from an unrelated donor should be considered for ATL even if the disease is refractory to chemotherapy.


Clinicians are advised to observe for symptoms of toxicity and to do serial blood levels to monitor this interaction.


This is known as a PSA "bounce" or "bump." Some patients experience a second transient rise in PSA levels after irradiation.


She rapidly developed profound CNS depression with stupor, hypothermia, hypoventilation and bradycardia.


On her next anticoagulation clinic visit, the patient's INR had increased, although the dosage of warfarin had been reduced when the tolterodine had been prescribed.


We conclude that autoimmune hemolytic anemia may be an unusual presentation for postirradiation sarcoma.


A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.


Rapid cycling in manic-depressives induced by tricyclic antidepressants.


A bone marrow aspiration test on day 16 showed a markedly increased number of activated macrophages showing massive hemophagocytosis.


Little is known about the behaviour of endogenous thrombopoietin (TPO) serum levels during rapid sequences of dose-intensified chemotherapy.


CASE SUMMARY: A 50-year-old white woman with a history of advanced breast cancer refractory to other treatment modalities was receiving vinorelbine.


Infected graft transplantation is an unwelcome complication that may lead to serious consequences in the immunosuppressed host.


MH was treated immediately with dantrolene; the patient recovered within 14 days.


He was discharged on March 15; myoclonic muscle spasms began that afternoon.


The case suggests that mechanical valve replacement may not prevent gastrointestinal bleeding in Heyde syndrome and that octreotide treatment should be considered in these cases.


The diagnosis can be accurately made with axial computed tomography (CT) of the involved spinal segment.


The clinical features and management of this combined intoxication are discussed.


Treatment with topical antibiotic agents did not improve the symptoms.


This is the first report of successful utilization of the prepuce as a skin graft to reconstruct a full thickness skin necrosis due to a phenobarbital extravasation to the forefoot of a newborn.


Pseudomonas corneal ulcer after use of extended-wear rigid gas-permeable contact lens.


The skin lesions were eczematoid patches, flaccid bullae and crusted plaques on the trunk and extremities, histologically showing a high epidermal blister with acantholysis.


We present a 20-year-old woman with Basedow-Graves' disease who developed PTU-induced fulminant hepatitis, which progressed to acute hepatic failure with grade III hepatic encephalopathy.


However, the electroretinogram was abnormal on several occasions during therapy with rifabutin, but returned to normal 3 months after withdrawal of the medication.


We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.


CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.


Photosensitive reflex epilepsy is provoked by environmental flicker stimuli.


Objective causality assessment revealed that the adverse event was probably drug induced.


This case demonstrates that severe anterior uveitis may develop after LASIK and needs prompt and vigorous management for resolution.


A review of the literature on the prognosis and treatment of aortoarteritis with particular reference to the management of recurrent valvular dehiscence is discussed.


We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.


Infections after tooth extraction and fracture of the sclerotic bone following mild trauma are serious complications, as these ordinarily common problems are very difficult to treat in such patients.


Infarction and necrosis may be common and incite complications from parasitic vascular attachment, pain and thrombosis.


One week after the termination of IFN therapy, TSH-receptor antibodies became positive and subsequently she showed Graves' hyperthyroidism.


In the two years following treatment there has been no recurrence while oral corticosteroid treatment has been continued.


Severe neutropenia due to chemotherapy was the most relevant risk factor.


We emphasize the need for long term follow up of patients treated with purine analogs and suggest that even those who are apparently cured be monitored periodically.


There was no residual corneal scarring.


The authors report a case of mania occurring in a woman in late life who had begun receiving hormone replacement therapy for osteoporosis.


Subglottic stenosis in Wegener's granulomatosis: development during cyclophosphamide treatment with response to carbon dioxide laser therapy.


Antihistone antibodies, lupus anticoagulant and anticardiolipin antibodies were negative.


Haematological malignancies developing in previously healthy individuals who received haematopoietic growth factors: report from the Research on Adverse Drug Events and Reports (RADAR) project.


Acute hepatic failure is a rare and potentially lethal complication of propylthiouracil (PTU) use for hyperthyroidism.


Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.


Four weeks later the patient was admitted to our hospital.


The authors describe a case of oral-facial dyskinesia that occurred after discontinuation of amoxapine, and antidepressant which may also have neuroleptic effects.


However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.


Ceftriaxone was approved in 1997 for the treatment of otitis media despite previous studies that documented an association of ceftriaxone with elevated hepato-biliary enzymes and transient biliary stasis.


The vitritis episodes resolved after 2 to 9 weeks.


CASE REPORT: Soon after initiation of amiodarone HCl (200 mg/day), a 76-year-old man came to us with symptoms of visual "shining," glare, color vision anomalies, and gradually decreased vision.


Evidence obtained indicated that the Reye-like syndrome might be caused by calcium hopantenate possibly due to the induction of pantothenic acid deficiency.


She was unresponsive to standard therapies, including racemic epinephrine and albuterol nebulizers.


An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.


This communication describes the profile of two children with unexpected, acute fatal neurologic toxicity during induction chemotherapy for ALL.


Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.


Serious adverse events experienced by patients with chronic heart failure taking spironolactone.


BACKGROUND: The skin contains a system for producing serotonin as well as serotonin receptors.


After three months, 17 (74%) out of 23 eyes showed a significant low endothelial cell count compared to the normal fellow eye ( P 0.001).


Thrombotic microangiopathy with renal failure in two patients undergoing gemcitabine chemotherapy.


Topical application of glucocorticoids and dimethisone is helpful.


PURPOSE: To report a case of nodular scleritis following alendronate sodium.


This observation also suggests that early administration of ribavirin in patients affected by acute syncytia; giant cell hepatitis of unknown origin could avoid liver transplantation.


G-CSF was used as an adjunctive therapy with discontinuation of carbimazole, barrier nursing and a broad-spectrum antibiotic regimen to treat her neutropenic sepsis.


Three of the four patients had a significant decrease in visual acuity as the result of a retinopathy, primarily affecting the region about the macula accompanied by macular edema.


These medications have been associated with cerebral arteritis, renal necrotizing vasculitis, and systemic and pulmonary hypertension.


A relatively uncommon but unique and life threatening iatrogenic condition is described.


A study of in vitro reactivity to L-T4, as assessed by peripheral blood lymphocyte transformation, was carried out in a patient with Hashimoto's disease who developed leukopenia during treatment with L-T4.


Widespread dermatophyte infections that mimic collagen vascular disease.


PURPOSE: We examined an 82-year-old woman with delayed-onset endophthalmitis caused by an opportunistic pathogen, Ovadendron sulphureo-ochraceum.


Possible mechanisms by which clonidine decreases spasticity are described, probable mechanisms of induced bradycardia are reviewed, and specific treatment recommendations for the use of clonidine in spinal cord injured patients are presented.


On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.


Suppression by propranolol and amiodarone of an electrical storm refractory to metoprolol and amiodarone.


The bronchospasm was severe in all three and in one patient resulted in respiratory arrest.


It most commonly occurs in association with hematologic malignancies and appears a few hours to a few days after initiation of specific chemotherapy, as the result from the release of intracellular components into the bloodstream due to abrupt malignant cell death.


Cerebellar hemorrhage after multiple manual pumping tests of a ventriculoperitoneal shunt: a case report.


Opioid-related narcosis is the most likely diagnosis in this case.


Neutropenic enterocolitis: a serious complication during the treatment of acute leukemias.


A hematopoietic stem cell transplant recipient developed abdominal pain, pneumatosis intestinalis, hepatitis, pancreatitis, and inappropriate antidiuretic hormone secretion.


The purpose of this study is to investigate the efficacy of tissue plasminogen activator (tPA) in the treatment of total hyphema following ocular trauma or intraocular surgery.


Primary herpes virus keratitis after penetrating keratoplasty.


Stomach and small intestine are the most affected organs; however, it can affect any part of the gastrointestinal system.


Our aim is to raise awareness of this drug, which is commonly used outside the United States, and to call attention to its well-known and potentially lethal side effect.


Furthermore, this case suggested that correct nonsurgical diagnosis of pelvic actinomycosis followed by prolonged antibiotic therapy might eliminate the need for extensive extirpative surgery and assist in maintaining future fertility.


Detection of PVB19-DNA in serum with quantitative polymerase chain reaction (PCR) revealed a high level of viral load.


Ziprasidone as an augmenting agent in the treatment of anxiety-spectrum disorders.


Soft-tissue masses are rarely associated with Histoplasma capsulatum infection.


He was treated with the immunosuppressive agents tacrolimus (0.15 mg/kg/d) and mycophenolate mofetil (20 mg/kg/d).


None had previously recognized acquired causes of QT, prolongation.


Case 2.


This is the first case of PML after SCT treated with cidofovir, and the fifth case treated with this drug in a patient without human immunodeficiency virus (HIV) infection.


CONCLUSION: Optometrists, particularly those actively participating in the shared care of refractive surgery patients, must be familiar with diffuse lamellar keratitis so that diagnosis is not delayed.


The former diagnosis was supported by a subsequent in-vitro HEPTEM.


The number of patients with chronic hepatitis C requiring interferon retreatment is increasing rapidly.


The use of 5-hydroxytryptamine (5-HT) antagonists such as cyproheptadine, however, has become more common and might reduce the duration of symptoms.


Although the t-AML developed following oral etoposide therapy, the child had previously received high-dose, multiagent chemotherapy, and rearrangement of the MLL gene was not demonstrated.


Chemotherapy-induced toxic leukoencephalopathy causes a wide range of symptoms: a series of four autopsies.


CASE: We report a case of a woman with severe human insulin-induced lipoatrophy who has been treated exclusively with recombinant DNA human insulin since the onset of IDDM.


We describe the first case of de novo asthma following treatment with the angiotensin converting enzyme (ACE) inhibitor captopril.


Four patients experienced persistent portal hypertension, which resulted in death in one.


Finally, leukocyte and platelet counts increased and remained within normal range following IgG therapy in the third patient having SLE-associated leuko- and thrombocytopenia.


Based on the Naranjo algorithm, the adverse reaction observed was probably related to the hydroxyurea treatment (score = 6); however, the hydroxyurea chemotherapy could not be discontinued because of the myeloproliferative disorder.


Potential role for topical clotrimazole in combination chemotherapy.


Acute intravascular hemolysis developed when a diabetic patient, previously treated with glyburide, was started on another oral sulfonylurea drug, chlorpropamide.


Following intensive chemotherapy, one died from acute leukaemia and the second is in complete remission.


Immunodeficiency, iatrogenic immunosuppression, and some autoimmune diseases are known as predisposing conditions, and in these patients PCNSL peaks in the 4th decade.


Therefore, we recommend that physicians evaluate serum theophylline levels closely when prescribing the 2 drugs in combination.


Simplifying psychotropic medication regimen into a single night dosage and reducing the dose for patients with chronic schizophrenia.


This misleading laboratory result and alternative methods of testing for proteinuria in tolmetin-treated patients are discussed.


Disseminated varicella infection is a potentially life-threatening complication of chronic high-dose corticosteroid (CS) or immunosuppressive therapy.


In addition, the possible association between these features and long-term IGF-I treatment is discussed.


Use of clonidine for chemical submission.


Therefore we recommend close follow up for patients that are switched from stavudine to zidovudine and, in case lactate measurement is not possible, free programs should provide safer drugs such as abacavir and tenofovir for patients that develop hyperlactatemia.


A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.


The images obtained were compared with images from patients without corneal disease.


Treatment of acute leukaemia in adult Jehovah's Witnesses (JW) is challenging because of 'a priori' refusal of most physicians to apply diagnostic and therapeutic procedures to haematological abnormalities resembling acute leukaemia.


This error occurred early in the institution's experience with concentrated topical epinephrine.


In those patients treated with beta blockers, decreased contractility and inability to increase heart rate further compromised cardiopulmonary function.


Thalidomide neuropathy is often associated with proximal weakness and may progress even after discontinuation of treatment, in the phenomenon of 'coasting'.


In this series, risk of osteonecrosis could not be attributed to corticosteroid use, parenteral nutrition or both forms of therapy administered together.


OBJECTIVE: To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen.


Low-dosage intravenous immunoglobulin in the management of a patient with acquired von Willebrand syndrome associated with monoclonal gammopathy of undetermined significance.


In the light of a brief review of literature, a prospective study of akathisia and tardive dyskinesia seems justified.


An 84-year-old woman was admitted to the hospital for progressive edema and decreased urine output.


All other laboratory values were within normal range.


Administration of intrathecal Ara-C in the same dose over longer intervals within 3-5 days between consecutive doses resulted in mild, transient neurological symptoms (paresthesias) in only one of 30 patients so treated.


Successful long-term control with lamivudine against reactivated hepatitis B infection following intensive chemotherapy and autologous peripheral blood stem cell transplantation in non-Hodgkin's lymphoma: experience of 2 cases.


Four weeks after the end of the chemotherapy she developed interstitial pneumonitis and irreversible lung fibrosis.


OBJECTIVE: Wernicke encephalopathy (WE) is an acute neurologic disorder characterized by a triad of ophthalmoplegia, ataxia, and mental confusion.


Strongyloides infections in transplant recipients.


Since the introduction of tumor necrosis factor-alpha (TNF-alpha) antagonists, various microbiologic agents have been reported to cause pneumonia following their administration.


CASE SUMMARY: A 61-year-old woman with no apparent risk factors for liver injury developed acute hepatitis one week after the final dose of a long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk) for onychomycosis.


We suggest ways to minimize this risk.


There have been more than 20 observations of the appearance or aggravation of this granulomatosis with interferon alfa and more recently with the combination of interferon alfa plus ribavirin.


One patient showed mild improvement (42.0% decrease in VAS).


MATERIALS AND METHODS: We present a case of ulcerative colitis in a pediatric liver transplant recipient.


Administration of cisplatin in three patients with carboplatin hypersensitivity: is skin testing useful?


CONCLUSION: If a parotid duct injury is diagnosed at the time of tumor extirpation, then surgical repair of the duct should be attempted, but if surgical repair is not possible or if an injury remains unrecognized until well after tumor extirpation, then surgery is not necessary.


The patient's cytopenias were refractory to treatment with corticosteroids, cyclosporine, intravenous immune globulin, rituximab, and pentostatin.


Additional application of FAB (2 x 80 mg) resulted in the immediate disappearance of arrhythmia.


Paradoxical ventricular tachycardia and fibrillation after intravenous bretylium therapy.


A closer look at septic shock.


Oral hypoglycaemics.


Poor hygiene and insufficient disinfection may be major risk factors for Acanthameoba keratitis in cosmetic contact lens wearers.


Embolia cutis medicamentosa following subcutaneous injection of glatiramer acetate.


The occurrence of neuromuscular blockade and the resulting potentiation of muscle relaxants during magnesium sulfate (MgSO4) administration is well known.


EEGs and Spect scan results were consistent with dysfunction in the left frontotemporoparietal regions of the brain.


Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.


BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.


Ten patients with palatal tremor have presented to this department over the last three years.


Life-threatening cranial dystonia following trihexyphenidyl withdrawal.


In the end, secondary forms of NH might coexist with classical primary NH.


No significant effects were observed in B-cell counts or the immune status of the newborn.


Subacute vincristine toxicity following five consecutive daily doses.


On chronic pain assessment he was having hyperalgesia to light touch in addition to the spontaneous chest pain.


Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature.


Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.


However, given the clinically significant result to the interaction between tolazoline and cimetidine we report, the use of cimetidine in tolazoline induced upper gastrointestinal hemorrhage should deserve more attention.


Nine of the 11 patients were also taking corticosteroids or corticosteroids with MTX.


New drugs have been introduced to manage the cardinal motor symptoms of PD, and other agents have been borrowed to treat the nonmotor manifestations of the illness.


The possibility of HUS during induction chemotherapy for ALL should be considered early on in the treatment regimen, if clinical signs and symptoms suggest this diagnosis, so that appropriate treatment can be instituted.


Eight patients with myelodysplastic syndromes (MDS) and four patients with aplastic anemia (AA) were treated with recombinant erythropoietin (rEpo) to investigate its effect on the anemia of these patients.


High-dose intravenous melphalan for plasma-cell leukaemia and myeloma.


The fourth was a 49-year-old female patient who was treated with multiple chemotherapeutics for Stage II breast carcinoma and subsequently developed visual acuity and field defects.


During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.


We describe the case of a 17-year-old boy with a right apical paraspinal Ewing's tumour in the neck treated with induction chemotherapy, high-dose chemotherapy (busulfan and melphalan) with peripheral stem-cell rescue and, 4 months later, radiotherapy to the primary tumour site (cervical cord received 50 Gy in 30 fractions).


METHODS: We employed an A-B-A-B single-subject research design that included clinical history, clinical findings, photographic images, and specular microscopic findings of ocular changes.


Blood samples were taken after clarithromycin coadministration and at 1 and 4 weeks after its discontinuation.


The effect of o,p'-DDD on adrenal steroid replacement therapy requirements.


A fatal case of theophylline intoxication is presented in which a number of factors leading to a decrease in theophylline clearance and the patient's death were possibly operative.


RESULTS: Including our own patient, a total of 26 cases of gemcitabine-associated HUS were identified.


In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.


No connection could be demonstrated between the eruption and other drugs or chemicals.


In 1991 the patient were found to be seropositive for HCV antibodies as detected by the ELISA method and confirmed by the RIBA method.


The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis.


We report the case of a 27-year-old woman with hyperthyroidism during pregnancy.


Administration of intravenous nitroglycerin in a patient with idiopathic pulmonary hypertension resulted in an increase in pulmonary artery pressure associated with a decrease in blood flow that is best explained by an increase in pulmonary vascular resistance.


Nine delirious patients suffering from lithium intoxication were examined with the Mini-Mental State Exam (MMS) to describe the clinical course of the disorder.


It is generally well tolerated.


Arthritis and bursitis in multiple sclerosis patients treated with interferon-beta.


The case reported here concerns the resolution of severe insomnia in a patient with global hypopituitary insufficiency upon adjustment of triple HRT to quadruple HRT.


Reactivation of herpes zoster in this case could have been coincidental, or secondary to LASIK and the subsequent use of topical corticosteroids following LASIK.


Reaccumulation of hemothorax occurred over the 48 hours following drain removal, necessitating insertion of a second drain, which removed 1400 mL of blood-stained fluid.


Our data support the continued use of liver biopsies in the surveillance of MTX-treated psoriatics.


CONCLUSIONS: The observation that neurotoxicity developed with a delay of 24 to 48 hours after acyclovir peak serum concentrations could explain the wide range of acyclovir levels reported in similar cases.


Chromosome abnormalities after chlorambucil therapy of polycythaemia vera.


Lansoprazole-induced thrombocytopenia.


We report the clinical course of a patient with bitemporal epilepsy who ingested 12 g of lacosamide, 56 g of gabapentin, 2g of topiramate, and 2.8 g of zonisamide during a suicide attempt.


Churg-Strauss syndrome, or allergic granulomatous angiitis, is an uncommon vasculitic syndrome.


Common factors among all patients included advanced age and use of a high-dose regimen.


Ventricular fibrillation during transesophageal atrial pacing in an infant with Wolff-Parkinson-White syndrome.


Rapid onset of quetiapine-induced diabetic ketoacidosis in an elderly patient: a case report.


Aspirin is one of the world's most commonly used medications and its use benefits many diverse conditions.


Prolonged enteroviral infection in a patient who developed pericarditis and heart failure after bone marrow transplantation.


The serum creatinine and blood urea nitrogen concentrations were 2.7 mg/dl and 70 mg/dl, respectively.


2-CdA typically causes a long-lasting state of immunodeficiency and the profound influence of this drug on the immune system has raised questions concerning the emergence of secondary neoplasms after its use.


Both had low levels of serum sodium, potassium and calcium.


The rate of infection in patients who require ventricular assist devices is estimated at more than 35%.


The increased use of serotonergic agents (alone and in combination) across multiple medical disciplines presents the possibility that the prevalence and clinical significance of this condition will rise in the future.


A 51-year-old male patient with living, unrelated kidney transplantation in Iran in June 2001, developed Plasmodium falciparum P. falciparum infection.


Ziprasidone is an atypical antipsychotic drug that is believed to have a low propensity for inducing extrapyramidal symptoms, including tardive dyskinesia (TD).


A newborn infant born with fetal hydrops had recurrent supraventricular tachycardia (SVT) that required repeated successful conversion by transesophageal atrial pacing.


The dark-adaptation curves were normal for one patient several months after isotretinoin therapy was discontinued.


Changed Michaelis-Menten parameters suggest that cisplatin increases the metabolic rate of phenytoin.


Intravitreal bevacizumab was administered and optical coherence tomography revealed worsening of the cystoid macular edema 1 month after the injection.


Intra-arterial therapy has the theoretical advantage of establishing a neurovascular diagnosis and high symptomatic artery patency rate but the disadvantage of requiring extra time and technical expertise.


OBJECTIVE: To report a case of possible foscarnet-induced severe hypomagnesemia and other electrolyte disorders.


BACKGROUND: A healthy 37-year-old African- American man was receiving treatment with trimethoprim-sulfamethoxazole double strength.


Starting with high-dose methylprednisolone treatment followed by defibrotide maintenance therapy the patient showed dramatic complete response of VOD, resulting in a normal sonography of the liver and normalization of laboratory values.


One month later, when the patient was free of symptoms, the follow-up free protein S antigen level was restored to the normal range.


Pramipexole is a Food and Drug Administration-approved antiparkinsonian agent, which, when used to augment antidepressants, would be considered an off-label use and should be discussed with the patient.


The course of this patient's renal disease contrasts sharply with diffuse proliferative glomerulonephritis of idiopathic systemic lupus, and suggests that this rare complication of procainamide therapy may have a favorable course.


We report a case in which the duration of action of 1 mg of vecuronium lasted 4 hours in a patient with severe preeclampsia whose serum magnesium level was in the therapeutic range.


Visual acuity remained unchanged in both eyes during follow-up.


Dermatitis to captopril.


Six months later, amiodarone treatment was reinstated due to life-threatening tachyarrhythmia; however, the patient remained euthyroid.


Sweet's syndrome associated with sargramostim (granulocyte-macrophage colony stimulating factor) treatment.


This sequence of events, i.e., cause and effect, has been referred to as the "holiday heart" syndrome.


We report AZA-induced drug eruption that developed in two cases of systemic scleroderma with polymyositis.


This report is of the successful treatment of a patient with multiply drug-resistant visceral leishmaniasis with a commercially prepared formulation of liposomal amphotericin B (L-AmB) ('AmBisome', Vestar, San Dimas, California, USA).


John's Wort while under psychiatric care are described.


His oral medications included topiramate, carbamazepine, olanzapine, quetiapine, guanfacine, and desmopressin acetate.


Thiabendazole given for 3 to 7 days is the treatment of choice for organ transplant recipients.


We report the first histopathologically documented case of oral mucosa pigmentation after OLP treatment with topical tacrolimus.


Predisposing factors such as the use of corticosteroids, the concomitan presence of an autoimmune disease (pemphigus foliaceus) and an infection of ehrlichiosis caused by Ehrlichia canis were observed.


A study following large patient groups on theophylline and a combination of theophylline and steroids might clarify the risk of ulcer formation in patients being treated with these medications for asthma.


A complete immunohistochemical study was performed on heart specimens.


Gastric variceal bleeding is a serious complication of liver cirrhosis.


One-year follow-up showed no recurrence.


The flares typically last for up to 3 days at a time, and most patients are completely asymptomatic between attacks; if untreated with prophylactic colchicine, some patients later develop amyloidosis and renal failure.


None of the patients required treatment for the overdose.


No risk factors for rhabdomyolysis were found, but the calcium-dependent potassium efflux, normally responsible for membrane hyperpolarization and muscle refractoriness, was severely decreased in the patient's red blood cells.


Preoperative risk factors, operative data, cardiopulmonary-bypass, postoperative complications and clinical symptoms are discussed together with ophthalmologic findings in order to elucidate the pathophysiology of this process.


A 54-year-old woman with recurrent adenocarcinoma of the uterus was treated with new third-generation cephalosporin, cefmenoxime, for a urinary tract infection.


A case of tuberculosis in a patient on Efalizumab and Etanercept for treatment of refractory palmopustular psoriasis and psoriatic arthritis.


His INR was 1.69 despite the increased warfarin dosage.


Herein we present a woman with bilateral lower extremity rest pain and a history of chronic ergot use for migraine headaches.


For pain relief an epidural infusion at the level T1-2 with bupivacaine was started.


P. falciparum can be transmitted in a hospital environment from patient to patient by blood inoculum if standard precautions are breached.


Colchicine-induced rhabdomyolysis is a rare complication, and the postulated mechanisms and risk factors for this severe complication are discussed.


Methemoglobinemia may occur in a number of drug or chemical ingestions, but a comprehensive review of the literature failed to identify a similar reported case.


We present a 46-year-old African-American man with AIDS who was admitted on two different occasions within three weeks for signs and symptoms of meningitis after using trimethoprim/sulfamethoxazole (TMP/SMX).


The possible underlying pharmacological mechanisms of this clinical reaction lend support to the cholinergic-adrenergic balance hypothesis of affective disorders.


Is akathisia a forerunner of tardive dyskinesia? A clinical report with brief review of literature.


Penile erections were regularly induced by intermittent subcutaneous injections of apomorphine in five patients with Parkinson's disease (PD) complicated by motor fluctuations.


Propafenone is an effective antiarrhythmic drug used widely for the treatment of supraventricular and ventricular arrhythmias.


CONCLUSIONS: The mechanism by which loop diuretics induce pancreatitis appears to be via an immunologic pathway.


Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy.


As ototoxicity appears to be most pronounced in the higher frequencies of sound, any changes can be assessed at an earlier stage by using high-frequency audiometry to test patients at frequencies from 8 to 20 kHz.


The rotator cuff tendons were noted to be intact and normal in appearance.


A 31-year-old woman developed pain, decreased vision, and a corneal flap infiltrate 4 days following laser in situ keratomileusis (LASIK).


The patient tolerated the rechallenge with fluorouracil without complications.


A literature review has identified only 9 additional cases.


CONCLUSIONS: We report this case of the concomitant appearance of multiple skin cancers and nail changes associated with hydroxyurea use.


Due to large chorioretinal scars the visual recovery was poor.


Adverse effects of atrial fibrillation and syncope induced by calcium-channel blockers in hypertrophic cardiomyopathy.


Tests for hepatitis A, B, and C were negative.


Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.


Since tamoxifen therapy can induce endometrial disorders, surveillance schemes of women taking tamoxifen have been recommended.


We believe this represents the most delayed reported thrombosis post-sirolimus-eluting stent implantation, which might not have been preventable using even the latest FDA recommendations.


When his carbamazepine concentration returned to previous levels, seizure control was not reestablished.


Of note is that the renal histology at autopsy showed a remarkable improvement of mesangial hypercellularity with concomitant reduction in the number of glomerular macrophages.


We report on a patient who presented an invalidating progressive pelvic dyskinesia while receiving different kinds of neuroleptic drugs for a psychiatric disorder.


The histological morphology of AILD-type T-cell lymphoma shows proliferation of small, arborizing high endothelial venules.


Adding morphine (5 mg/60 mL levobupivicaine) permitted a reduction in infusion rate.


Dapsone (4-4-diaminodiphenyl-sulfone) is a member of the sulfone group of antibiotics used in the treatment of leprosy and various dermatitidies and more recently employed in the management of local reactions to the bite of the brown recluse spider, Loxosceles reclusa.


Severe hepatocellular dysfunction following cyproterone acetate therapy.


Within 4 days of discontinuing the pentamidine, the patient's heart rate stabilized at 80 beats/minute without further intervention.


This is, to the best of our knowledge, the first report of a case in which agranulocytosis followed treatment with both propylthiouracil and methimazole in the same patient.


Efficacy and safety of linezolid in multidrug resistant tuberculosis (MDR-TB)--a report of ten cases.


Although a definitive causal relationship between the steroids and AI was not established, their temporal association and the exclusion of other possible etiologies led us to postulate that AI was a complication of the steroid protocol.


Two months into his second-line chemotherapy, he developed multiple, concomitant, transverse and longitudinal black lines in all of his fingernails and toenails.


Methylphenidate is a potent central nervous system stimulant that exerts its effects by increasing synaptic levels of dopamine and norepinephrine.


Toxic hepatitis induced by disulfiram in a non-alcoholic.


DISCUSSION: Drug-induced LABD is a variant of classic or idiopathic LABD.


Anaphylaxis after the injection of chymopapain occurs in about 1% of such cases.


The relevant literature is reviewed; a case history is presented; and implications for nursing care (e.g., early detection) are discussed.


CONCLUSIONS: Ovulation induction therapy with clomiphene citrate may precipitate uveitis.


METHODS: We report the first case of orbital cellulitis following Faden operation on the medial rectus muscle.


Gold nephropathy.


This study underscores the risks of routinely administering protamine to susceptible individuals and the need for alternative therapies.


Methimazole-associated cholestatic liver injury: case report and brief literature review.


The duration of each infusion should be minimised and blood volume should be carefully monitored throughout.


SUMMARY OF BACKGROUND DATA: Symptomatic spinal epidural lipomatosis is considered to be a rare condition usually presenting with slowly progressive cord or nerve root compression.


Once clonidine was discontinued, the resting heart rate returned to normal.


After successful treatment, she was given demeclocycline prophylactically and rechallenged with vinorelbine without recurrence of the syndrome.


Herein we reported a case of reactivation of sarcoidosis occurring during the treatment of chronic hepatitis C, and we present a literature review of other centers' experiences with this problem.


Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.


Rhino-orbital zygomycosis is usually an aggressive, fulminant and, at times, fatal disease that requires urgent medical and surgical treatment.


Report of two cases with evidence from serial computed tomographic brain scans.


Histopathological findings include focal vacuolar alteration of the basal layer with cytoid bodies, dermal and intraepidermal multinucleated giant cells and a mixed chronic inflammatory infiltrate with a lichenoid pattern consisting of lymphocytes, histiocytes, eosinophils and plasma cells.


CONCLUSIONS: Jet-injection devices might constitute a helpful method to treat those patients affected by severe human insulin-induced lipoatrophy.


Patients were followed up clinically with slit-lamp examination for evidence of tumor disappearance or recurrence, and local and systemic side effects.


Renal pathologic findings were consistent with minimal change nephrotic syndrome (MCNS) showing extensive foot process effacement of visceral glomerular epithelial cells (podocyte).


CONCLUSIONS: Good visual outcome after early debridement and appropriate antibiotics was achieved.


Sodium phenylbutyrate was added to treatment with HU in two patients, but failed to produce an increase in total Hb despite increasing Hb F levels.


Actinomyces-like organisms were seen on cervico-vaginal smears.


The patient underwent a dorsal laminectomy, and arachnoidal calcification and ossification was find, but the removal of the bone plaques was ineffectual in order to the subsequent course of the neurological troubles.


These two cases of acute leukemia, which developed 3 years after diagnosis of breast cancer and initiation of chemotherapy, were characterized by trilineage dysplasia and pancytopenia, and had abnormalities of chromosomes 5 and 7: characteristics consistent with treatment-related leukemia.


Pulmonary resection was finally performed because of acute progressive respiratory failure due to massive recurrent hemoptysis.


Further studies on the precise association with different therapies are thus needed.


Other causes of the disease were ruled out.


After completion of chemotherapy the patient remained in a complete remission and free of new thromboembolic events.


Most cases are managed by oral surgeons with only a handful of reports appearing in the otolaryngology literature.


In conclusion, the locally prepared LC was able to control the bleeding episodes in a haemophilia A patient with high inhibitor.


We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.


A patient is described who developed a rapid onset of pulmonary fibrosis following treatment with a new non-steroidal anti-inflammatory drug, nabumetone.


Aminophylline hypersensitivity apparently due to ethylenediamine.


The observation is consistent with reports linking psychomotor abnormalities and psychosis in severely depressed juveniles to an increased propensity for manic switching, as well as adult studies that report a greater risk of antidepressant-induced cycling in bipolar compared with unipolar affective illness.


We report the first case of hairy cell leukemia occurring after cardiac transplantation.


2-CdA induces lymphocytopenia, which may explain the improvement in this patient's psoriasis.


RESULTS: In these four patients, the use of caspofungin as an additional drug to the standard trimethoprim-sulfamethoxazole regimen led to a rapid improvement and a complete cure of pneumonia.


A case of nephrotic syndrome treated with associated cyclophosphamide and corticosteroids came to our attention after over 2 years of self-administered immunosuppressive therapy which remained unchanged and uncontrolled during this period.


Cognitive and speech functions were specifically tested during the evaluation.


Diltiazem therapy was discontinued, leading to resolution of fever within 48 hours.


The patients had received anthracyclines and methotrexate, a known nephrotoxic chemotherapeutic agent.


In conclusion, the in vitro susceptibility assay as well as nucleotide sequence of clinical isolate is important to choose appropriate antiviral agents for patients who have persistent CMV reactivation after stem cell transplantation.


If neovascularization occurred at the site of the anastomosis, intravitreal bevacizumab (1.25 mg) was injected followed by laser photocoagulation to areas of retinal ischaemia and the area of retina anterior to the L-CRA 1 week later.


Mycobacterium tuberculosis was isolated in a culture of peritoneal fluid, and the patient responded promptly to antituberculous therapy.


Eosinophilic pleural effusion is defined as an effusion in which eosinophils constitute more than 10% of white blood cells.


Five months after initiating mirtazapine therapy, she developed symptomatic hyponatremia.


We report on the clinical phenotype and infantile development of a girl born to a 36-year-old mother.


Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation.


The other patient had one of four primary BCCs respond completely, and the remaining three respond partially.


However, there remain questions concerning whether these drugs, especially methimazole (MMI), may be associated with aplasia cutis congenita (ACC) and how best to avoid impairment of fetal thyroid function during their use.


Theoretically, insulin-sensitizing thiazolidinediones (TZDs) should be beneficial in this patient population.


One of the mainstay pharmacologic therapies for ADHD has been stimulants.


Gastric tumor, endometrial carcinoma and cervical adenocarcinoma in situ were detected after treatment with tamoxifen for breast cancer.


A 42-year old woman with neck pain was prescribed 15 g of 'maqianzi' to be taken in two doses at 7 hours apart, although the recommended dose was 0.3-0.6 g.


It is generally thought that doses below 500-550 mg/m2 are safe but, when objective measures of cardiac function are used, it becomes apparent that degrees of cardiac failure occur at doses below this.


The 2 cases direct our attention to at least 3 important points regarding safe administration of ECT shortly after the occurrence of PE, that is, careful evaluation of cardiac function and residual deep vein thrombosis before the start of an ECT course, adjustment of anticoagulants, and prevention of recurrent deep vein thrombosis and PE by methods in addition to anticoagulant therapy (fluid infusion, use of support hose, and timely ECT).


Subsequently, the patient developed pulmonary emboli documented by angiography.


This report suggests the importance of searching for the presence of C. difficile and its toxin in patients with diarrhea after undergoing cancer chemotherapy since C. difficile may cause severe colitis.


Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide.


Herpes zoster ophthalmicus and syndrome of inappropriate antidiuretic hormone secretion.


With drug rechallenge two days later, ventricular tachycardia recurred within minutes.


Use of the Naranjo probability scale showed the relationship of itraconazole therapy and the occurrence of acute hepatitis as probable.


These results provided consistent evidence that the selective absence of VWFMs with large to medium molecular masses in this patient is caused by the heightened clearance of a complex of IgG inhibitor and VWFMs from the circulation, presumably through IgG binding to the Fc receptor of macrophages.


Autoinfection occurs in the setting of immunosuppression when invasive larvae penetrate the gut wall and cause disseminated infection.


Failure of coagulation was confirmed by thrombelastography and in both cases routine coagulation tests revealed a prolonged kaolin cephalin clotting time (KCT).


Development of obsessive-compulsive behaviour following cortisone treatment.


RESULTS: Since January 2002, 171 patients with RA have commenced taking leflunomide.


At ophthalmic review, the tumour had apparently completely regressed.


METHODS/RESULTS: This paper presents a new case of rifabutin uveitis and a review of the various published reports to date.


It is concluded that cyclophosphamide and thiotepa in obese patients should not be dosed on the basis of BSA incorporating TBW since the patient will be overexposed.


The patient had tolerated both general and local anaesthesia on several previous occasions.


Record et al. have recommended oral loading in selected patients.


Two weekly injections of 25 mg of the tumour necrosis factor alpha inhibitor etanercept led to a rapid improvement of his psoriatic arthritis, as well as regression of the pustular eruption, while residual erythema was still present.


CONCLUSION: Gemcitabine-induced recall pneumonitis is a rarely reported phenomenon and should be taken into account even after extended time interval to the previous radiotherapy.


Clinicians should be vigilant when monitoring for cardiotoxicity in patients receiving pentamidine throughout the duration of therapy.


The level of aspartate aminotransferase (AST) was 44 U/L, and that of alanine aminotransferase (ALT) was 69 U/L.


She experienced two separate episodes of observed fits whilst on an initial daily dose of 125 mg and, subsequently, on a daily dose of 237.5 mg.


CLINICAL PRESENTATION AND INTERVENTION: A 50-year-old male with chronic hepatitis C received treatment with alfa-interferon and ribavirin for 52 weeks.


Her antecedent medical history included stable, mild renal function impairment, mitral regurgitation, atrial fibrillation, recurrent transient ischaemic attacks and cholelithiasis.


Following the widespread use of GVO, more severe complications such as needle cementation, fistula formation, embolic sequels, recurrent septicemia, etc., have been reported.


His symptoms resolved within 2 weeks of discontinuing the isoniazid.


Cutaneous seeding is a rare complication of interventional ultrasound procedures.


The concomitant use, however, of colchicine and statin has been associated with the rapid onset of muscle weakness.


Only one patient, the youngest, did well on risperidone therapy.


In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.


One year later, she experienced a fatal hepatitis B virus (HBV) reactivation.


The thrombus occupied almost half the right atrial cavity and hit the tricuspid valve with each heartbeat without obstruction of tricuspid inflow.


Bisphosphonates inhibit bone turnover and result in increased bone-mineral density.


Although various other cardiac events have been reported in literature, a series of patients having transient asymptomatic bradycardia has not been reported in the literature as yet.


As children are often unable to describe their symptoms verbally, their akathisia can be misdiagnosed as worsening of their psychosis, prompting an unnecessary increase in their neuroleptic dose.


A 41-year-old woman was treated according to a diagnosis of depression, which was her 6th episode.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


Fundus examination revealed resolution of cystoid macula edema.


Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates.


On admission rhabdomyolysis had begun to improve despite a worsening of the hyponatremia (113 mEq/L).


Two brief periods of analgesia were achieved with deep subcutaneous infiltration of bupivacaine.


Chronic ischemic changes in the white matter may have been an additional factor in the causation and, most likely, in the duration of his status.


The cases of two asthmatic patients who became hypokalemic after inhalation of normal doses of albuterol are presented.


The failure of high doses steroids to alter the course of illness and to completely suppress the thyroidal inflammatory process is highlighted.


We report marked QT prolongation and torsades de pointes in a setting of flash pulmonary edema resulting from acute myocardial ischemia in a patient who was being treated with dofetilide for atrial fibrillation.


Although it is difficult to be certain of the direct link of amiodarone on the basis of a single case, it is reasonable to presume that this histopathology is associated with amiodarone-induced hypothyroidism and that involution changes represent the hypofunctional status of this drug-induced disorder.


A patient with the Wolff-Parkinson-White syndrome presented with incessant orthodromic atrioventricular tachycardia following initiation of procainamide therapy.


The resuscitation attempt was unsuccessful, and the patient was pronounced dead.


In these cases, the pregnancy can be protected through anticoagulation treatment, but there may be exceptions to this.


Although transient increases in ectopy after bretylium therapy have been described, presumably due to catecholamine release, the occurrence of life-threatening ventricular arrhythmia leading to cardiac arrest has not previously been emphasized.


Since complete surgical excision was not feasible, she was treated with repeated multiple local injections of triamcinolone acetonide.


Antibiotic irrigation of the capsular bag to resolve low-grade endophthalmitis.


Our case is that of a 44-year-old woman, along with a review of the literature.


PURPOSE: To report patients who presented to the oculoplastics department for repair of cicatrical entropion after topical use of dipivefrin.


We can speculate that the overexpression of VEGF induced by local ischemia and inflammation can make these patients more likely to have CNV.


However, 9 months later, while still asymptomatic, routine physical examination revealed a recurrent right lower quadrant tumor.


Although the patient's symptoms are consistent with those of the condition, she did not respond to treatment with haloperidol, flunarizine, or propranolol.


I saw two patients with kala-azar resistant to sodium stibogluconate who developed cardiac arrest after amphotericin infusion (in spite of tolerating a test dose).


BACKGROUND: Nocardia asteroides is an opportunistic infection caused by an aerobic actinomycete, which, in the immunocompromised host, can be associated with severe invasive disease with a predilection for the brain.


These drugs, phosphodiesterase 5 (PDE5) inhibitors, help men with ED obtain and sustain an erection, improving both sexual function and sexual performance satisfaction.


Pursuing a diagnosis in a Caribbean man.


Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation.


CONCLUSIONS: Clinicians should be aware of this adverse reaction when facing similar complex neurologic symptoms in patients who are receiving the antibiotic treatment described here, especially vancomycin.


Clinical evaluation of SMS 201-995.


CONCLUSIONS: Neurosurgeons will be faced with another devastating complication of thrombolytic therapy, as long as the available drugs are being used.


A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.


The syndrome of inappropriate antidiuretic hormone (SIADH) secretion is a common consequence of neurologic and pulmonary infections as well as drug intake and many other clinical situations.


Use of lamotrigine to augment clozapine in patients with resistant schizophrenia and comorbid alcohol dependence: a potent anti-craving effect?


High-dose methotrexate is used in malignant hemopathies and solid tumors in children.


The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.


Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature.


The episodes became more frequent in the following months, causing several falls and requiring visits to the emergency department, but no acute coronary event was diagnosed.


However, an association of Ritalin with glaucoma has been reported.


Methamphetamine abuse has been increasing in California and may exceed cocaine abuse in some regions.


Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.


The diagnosis was based on the rapid onset of renal failure, presence of eosinophilia, skin rash, and characteristic renal biopsy finding, following the administration of ampicillin.


Venous thrombembolism, thrombophilic defects, combined oral contraception and anticoagulation.


It is estimated that the real incidence if TIAA is higher, and many cases, initially presented as agranulocytosis +/- thrombocytopenia, might be true aplastic anemias, not proven by marrow aspiration or trephine biopsy.


A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g.


An electrophysiologic study revealed an intermittent advanced (His-Purkinje) block within the atrioventricular conduction system.


Although the great majority of these events occur at sites of vascular interruption, major gastrointestinal, retroperitoneal, genitourinary, and central nervous system hemorrhage are known to occur.


Central nervous system toxicity associated with meperidine use in hepatic disease.


OBJECTIVE: The purpose of this study was to determine whether desensitization to NPH insulin, as well as standard insulin desensitization, could control allergic symptoms in a patient allergic to both NPH and regular insulin.


The relationship between tardive OGC and clozapine is still unknown.


BACKGROUND: With the increasing use of implantable cardioverter-defibrillators (ICDs), device complications are becoming more common.


The patient experienced pain relief after the first application.


She experienced deterioration in vision following the commencement of treatment due to a Jarisch-Herxheimer reaction.


Valproate 960 mg (30 mg/kg) was infused over 1 hour.


At final follow-up, the patient complained of a grade 4/5 hemiparesis, facial nerve palsy, and hearing loss in his left ear.


This is a diagnosis that should be considered in patients with prostate cancer who present with hip pain in the absence of biochemical evidence of disease progression.


We cared for a toddler in whom severe respiratory distress developed after VVR was applied directly under her nose.


As a result, one of these individuals had premature death.


Steroid therapy is an effective method of protecting the airway in some patients with hemangiomas.


This compound, used by adults in the child's home, had caused accidental theophylline poisoning, mimicking diabetic ketoacidosis.


Discontinuation of dalteparin on day 4 led to resolution of symptoms.


Anastrozole-associated sclerosing glomerulonephritis in a patient with breast cancer.


She suffered from epigastric discomfort.


In each case, a surgical opinion was required.


This led to a rapid unfavorable progression of hepatitis B, which was recently acquired and subsequently evolved into a severe cholestatic and fibrosing chronic hepatitis, causing multiple end-organ failure, and ultimately, death.


Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia.


Clofazimine enteropathy caused by crystal deposition can be life-threatening.


The patient's previous rash and the temporal relation of this event and the ingestion of phenolphthalein, as well as the similarity of this case to other reports, point to phenolphthalein as the cause of TEN in this patient.


The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.


Glucocorticoids were administered at dosages that provided 1/3 to 1/2 of her expected maximal daily cortisol secretion during her complicated hospital course.


BACKGROUND: Agenesis of the inferior vena cava (IVC) is an uncommon congenital vascular malformation.


The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.


Histiocytic lymphoma of the ileocecal region developed in a patient with multiple myeloma following successful long-term alkylating agent therapy.


Because of his chronic diarrhea, this patient underwent colonoscopy, which revealed diffuse erythematous mucosa, multiple ulcers, exudate, and pseudopolyps with a diffuse loss of vascularity.


PURPOSE: To report a case of Serratia Marcescens corneal ulcer as a complication of orthokeratology treatment.


Laparoscopic surgery is inappropriate in patients with malignant ascites or when preoperative or intraoperative findings are suggestive of ovarian cancer.


Four patients remained dialysis-dependent and died within 4 weeks of presentation.


High signal intensity in periventricular white matter was observed on T2-weighted magnetic resonance imaging.


Multicyclic dose-intensive chemotherapy supported by autologous blood progenitor cell transplantation for relapsed small cell lung cancer.


Spontaneous intracerebral hemorrhage was diagnosed, despite an initial negative CT scan.


By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.


MAIN OUTCOME MEASURES: Visual acuity, color vision, Goldmann perimetry testing, and fundus photography.


Recombinant human alpha-interferon (IFN) at a dose of 3 million units combined with melphalan and prednisolone was administrated.


AIMS: The aim of this study was to report on the effectiveness and tumor side effects of topical interferon (INF) alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia (CIN) of a patient that rejected any surgical procedure.


Five weeks later, the patient underwent arthroscopic evaluation of the shoulder and subacromial decompression.


The occurrence of additional signs and symptoms should alert the clinician to the presence of intracranial pathology.


A nerve conduction study showed conduction block at the elbow, indicating possible cubital tunnel syndrome.


An immediate hemolytic reaction induced by repeated administration of oxaliplatin.


Neuroleptic malignant syndrome in a burn patient.


The first was a 56-year-old male treated with multiple chemotherapeutics for multiple myeloma.


Radiation therapy is a powerful method for the control of cancer.


Anaphylaxis to cisplatin following nine previous uncomplicated cycles.


The reported case represents an unusual association between medication with the proton pump inhibitor lansoprazole and the development of collagenous colitis suggesting the importance of evaluation of drug use in patients with microscopic colitis.


At delivery the umbilical cord plasma concentration was similar to that in the maternal venous plasma.


Repeated open application tests with amcinonide and triamcinolone acetonide cream on the ventral aspect of the upper arm were negative.


After reviewing the current literature, we suggest that there is no dose of methadone that may be considered to be completely safe.


This is the first description, to our knowledge, of ductopenia apparently caused by clindamycin.


The patient was treated with corticosteroid therapy and surgical resection of the jejunal tumor.


In our experience, the correct diagnosis and effective treatment at an early stage proved to be helpful to the patients in pulling out from the critical stage of acute radiation sickness.


Despite the extraordinary course in this patient, complete recovery took place, confirming the benign nature of even such a prolonged episode.


The nocturia was defined as having more than two episodes of urination during sleep per night on average.


Heart Vessels 2006;21:124?6].


A 27-year-old man presented with corneal ectasia in his left eye 4 years after myopic laser in situ keratomileusis (LASIK) and was treated with riboflavin-ultraviolet-A (crosslinking).


The patient underwent an elective termination of an intrauterine pregnancy and subsequently was diagnosed with a pulmonary embolus, which delayed the diagnosis of her ruptured ectopic pregnancy.


Neurotoxicity occurs most often with intermittent high dose 5-FU as bolus injection or 24- to 48-h infusions.


Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies.


Indications for GBP treatment were newly diagnosed epilepsy in one and painful paraesthesiae in the other.


Up to now, all investigations have failed to show a relapse of her adenocarcinoma.


Acute neutrophilic dermatosis induced by all-trans-retinoic acid treatment for acute promyelocytic leukemia.


Reversible treatment-related leukoencephalopathy.


Palliative radiation therapy was given.


We report the case of a 20-year-old woman originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin.


Multifocal osteonecrosis following chemotherapy and short-term corticosteroid therapy in a patient with small-cell bronchogenic carcinoma.


CLINICAL FEATURES: A 61 yr old man with severe mitral regurgitation and chronic obstructive lung disease underwent surgery for mitral valve repair.


All patients who died developed disseminated intravascular coagulation, and at postmortem examination were found to have had cerebral haemorrhage.


Valacyclovir is an effective oral agent for the treatment of herpes virus infection, however, the pharmacokinetics of the drug are altered in renal failure.


CONCLUSION: The hemolytic-uremic syndrome may be a rare complication of oxaliplatin-based chemotherapy.


The introduction of para-aminosalicylic acid (PAS) led to hypoglycaemic coma.


We report our conventional magnetic resonance and diffusion-weighted imaging findings and briefly discuss the pathophysiology of the syndrome.


In one child, a second course of carbamazepine resulted in a return of the dystonia.


The clinical manifestations, differential diagnosis, and treatment of the neuroleptic malignant syndrome and neuroleptic-induced catatonia are discussed.


Bone formation induced in an infant by systemic prostaglandin-E2 administration.


In all three cases, autopsy revealed gross and microscopic features indistinguishable from those seen in the Hamman-Rich syndrome, and methotrexate hepatotoxicity was present in one.


The patient had recurrence of urticaria and angioedema a year and a half later, at which point the NPH was stopped and she was desensitized to regular insulin.


She tolerated the surgery well and was discharged on postoperative day 5.


Primary cutaneous coccidioidomycosis and subsequent drug eruption to itraconazole in a dog.


CASE REPORT: We present a case of a 28-yr-old male who developed a severe case of nephrotic syndrome while being treated for relapsing/remitting Multiple Sclerosis (RRMS) with weekly injections of interferon beta 1a.


However, the other antitubercular drugs were continued along with 40 mg of prednisolone in a single daily morning dose.


Patients received CAP 1200-1600 mg/m2 in two divided doses with XRT (total 5040-5400 Gy) x 6 weeks, followed by 4 weeks rest, then 6 cycles of CAP 2000-2500 mg/m2 in two divided doses x 14 days every (q) 3 weeks.


Progressive hypokalemia developed during phosphate treatment.


Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.


Some kindreds with familial parkinsonism exhibit genetic anticipation, suggesting possible involvement of trinucleotide repeat expansion.


Non-lithium-induced renal failure with secondary lithium toxicity: case reports.


These cases, combined with other reports in the literature, suggest strongly that these drugs are fetotoxic.


Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril.


In both cases, high fever, skin rash, liver dysfunction and atypical lymphocytosis developed 3 weeks after initiating treatment with SASP.


Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened.


In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.


Adrenal suppression was discontinued, and she was reevaluated for hypercortisolism.


The effects of aprotinin, a broad-based proteinase inhibitor, in the management of hemorrhagic complications during prolonged venovenous extracorporeal CO2 removal in patients with adult respiratory distress syndrome are not evaluated.


The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.


We report a case of shunt infection subsequent to insertion of a ventriculoatrial shunt for obstructive hydrocephalus caused by a cerebellar hematoma.


Medical records and kidney biopsy specimens were reviewed and relevant data were collected.


Meperidine-associated central nervous system (CNS) excitatory toxicities are believed to be caused by accumulation of the active metabolite normeperidine.


Clomipramine was tapered and reduced to 50 mg over a period of 10 days.


The most common associated cancers are ovarian, lung, pancreatic, stomach, colon and non-Hodgkin's lymphoma.


This condition rapidly diminished after administration of intravenous antihistaminics and did not necessitate cessation of VRC treatment.


Heavy proteinuria then developed and the drug was stopped.


We believe these cases highlight important and potentially irreversible side effects of this agent and emphasize the need for further studies of the renal safety of TDF in pediatric patients.


Trihexyphenidyl and isoprinosine in the treatment of subacute sclerosing panencephalitis.


We report two patients with anhedonic ejaculation (ejaculation without orgasm) associated with initiation of treatment with desipramine.


There was no evidence of recurrent myeloma after the initial remission on cyclophosphamide therapy.


Development of hypertension in neuroblastoma during therapy: a case report.


Tolazoline induces a dilatation of the pulmonary vascular system by stimulating H2 receptors.


Inflammatory changes were observed in four out of nine patients on HAART and in one out of 19 patients not on HAART.


Despite they can be distinguished through clinical and histological characteristics; both are often used as synonyms.


All patients experienced an increase in hematocrit level.


Pulmonary nodules caused by Schizophyllum commune after cardiac transplantation.


Prolonged severe 5-fluorouracil-associated neurotoxicity in a patient with dihydropyrimidine dehydrogenase deficiency.


A 47 year-old woman who had a 4-year history of intramuscular pentazocine injections in the lower extremities, developed gradual stiffness and weakness of the lower extremities.


Initially, National Institutes of Health Stroke Scale score was 21, and 24 hours later it improved to 9.


Hepatic artery aneurysm associated with upper gastrointestinal bleeding after intrahepatic artery chemotherapy.


This case, although rare and atypical, should alert clinicians to consider the possibility of NMS as a complication of abrupt neuroleptic drug withdrawal.


Physicians should be careful not to rule out the diagnosis in patients of high-risk ethnic backgrounds just because of atypical clinical features, as our data indicate that MEFV mutations are sometimes demonstrable in such patients.


Transfusion-associated graft-versus-host disease (TA-GVHD), has rarely been reported associated with B-chronic lymphocytic leukaemia (B-CLL).


Pharmacologic and psychotherapeutic issues in coexistent paranoid schizophrenia and narcolepsy: case report.


Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.


In order to prevent GVHD, CsA alone was administered, 3 mg/kg i.v. per day for a total of 40 days.


These observations indicate that submassive hepatic necrosis may result from treatment with propylthiouracil and are consistent with the notion that sensitization mechanisms may be responsible for the hepatic injury induced by this drug.


The mechanism of leukopenia is thought to be secondary to either an immune-mediated response or direct bone marrow toxicity.


Reports of corticosteroid anaphylactic reactions are rare in the medical literature.


It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms.


A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure.


Ophthalmologic and neurologic findings in two children exposed to vigabatrin in utero.


Fixed drug eruption in hands caused by omeprazole.


A 14-year-old boy with chronic granulomatous disease and severe infection was admitted to the hospital because of left shoulder aspergillus' infection and pain.


Pertinent literature was reviewed to provide supporting evidence for the mechanism and clinical implications of the drug interaction.


We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.


This case study describes an atypical case of refractory, sodium warfarin-induced necrotizing fasciitis and myonecrosis.


RESULTS: The patient with the primary perforation was managed conservatively, while the second was subjected to immediate surgical exploration.


He now realised that he had eaten a chocolate cake before this episode and remembered that before the first episode he had had a chocolate mousse dessert.


All of the patients responded with increased levels of Hb F, but the responses in total Hb varied.


PATIENT AND METHODS: We report on a patient suffering from metastatic rectal cancer.


Debris was probably flushed into the external carotid artery, and passed through an anastomosis into the ophthalmic artery, resulting in retinal artery embolization.


Animal studies suggest central D2-type dopamine receptor stimulation and oxytocin release from the paraventricular nucleus of the hypothalamus mediate the effect.


At 1 year of age cardiovascular and renal function is normal, but there is developmental delay.


We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.


After the second course he developed persistent symptoms of nausea, vomiting, and pain.


We report an unusual pattern of supravenous hyperpigmentation occurring after CHOP chemotherapy.


Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.


This suggests that trial chlormadinone acetate withdrawal in patients showing increasing levels of PSA during combined androgen blockade should be considered before initiation of alternative treatment.


The first day after biopsy, the child developed gross hematuria and abdominal pain and an antibiotic was added to her treatment.


Adverse reactions, however, are relatively common as well.


Mechanisms for creating this effective host response need further investigation.


He wore a retainer lens, rigid gas permeable lens, overnight for 2 months before the corneal ulcer occurred.


The aim of this study is to draw attention to the adverse effects of henna, applied over the whole body, observed in glucose-6-phosphate dehydrogenase (G6PD) enzyme deficient siblings.


An esophago-gastro-duodenal examination was performed which showed antritis and duodenitis consistent with radiation therapy.


Divalproex sodium-induced eosinophilic pleural effusion.


In 1 patient, leukoencephalopathy was progressive and irreversible brain damage and mental retardation persisted.


Intravenous diazepam exacerbated the seizures.


The possible mechanisms for this complication in out patient are discussed.


Recurrent life-threatening episodes of ventricular tachycardia persisted despite maximal antiarrhythmic theraphy with amiodarone, metoprolol and mexiletine.


Asthma is one of the most common chronic medical conditions.


The recombinant human IgG1 monoclonal antibody specific for human TNF-a adalimumab (Humira) has been recently introduced for the treatment of moderate/severe psoriasis.


His pulse rate was 90 min(-1) and his respiratory rate was 20 min(-1).


Reflex vasospasm induced by the injection trauma may be etiologically involved.


The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.


Trazodone therapy was continued or reinstated shortly after the hypomanic episode without further evidence of hypomania.


Complete resolution of symptoms within 1-4 days was accompanied by normalization of ADC abnormalities.


Drug discontinuation resulted in complete resolution of the clinical and radiographic picture.


Secondary pancreatic involvement by diffuse large B-cell lymphoma presenting as acute pancreatitis: treatment and outcome.


Patients reported a decrease in episodes of spontaneous sleeping during the day, fewer myoclonic twitches, improved daily function and greater social interaction.


We present a patient who developed extensive Molluscum Contagiosum (MC) lesions shortly after being started on HAART.


The total amount of vitamin K received from the enteral feedings ranged from 50 to 115 micrograms/day, which is less than the normal daily intake of 300 to 500 micrograms.


Acute sensorineural hearing loss following intravenous ketoralac administration.


Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.


CONCLUSION: We report herein the fifth case of visceral leishmaniasis in a patient under TNF-alpha therapy, and the first one, to our knowledge, presenting a consequent secondary macrophagic activation syndrome.


We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.


A 39-year-old female presented for elective bilateral thoracoscopic splanchnicectomy for chronic severe visceral pain.


However, there remain questions concerning whether these drugs, especially methimazole (MMI), may be associated with aplasia cutis congenita (ACC) and how best to avoid impairment of fetal thyroid function during their use.


The mirtazapine plasma-level was 368 ng/ml still after 41 hours.


the disease has been described mainly in patients treated with systemic corticosteroids (39 cases out of the 71 reported cases) or local corticosteroids (3/71) and in patients suffering from Cushing's syndrome (7/71) but rarely in HIV-infected patients (3/71).


In this paper we report a case of nimodipine overdosage resulting in prolonged hypotension and hypoxemia, which was successfully treated with calcium gluconate.


We report a case of autoimmune hepatitis likely triggered by the use of black cohosh (Actaea racemosa), an agent marketed to treat menopause symptoms.


Despite effective treatment with high-dose trimethoprim-sulfamethoxazole and steroids, morbidity is often severe and lethality remains high.


Acute aflatoxicosis: case report.


The third patient had dyspnea on exertion, unchanged over two months.


Rapid liver failure related to chronic C hepatitis in an HIV seropositive hemophilic patient with severe immunodepression.


Tetany in a child with AIDS receiving intravenous tobramycin.


Before the introduction of anti-vascular endothelial growth factor (VEGF) drugs, photodynamic therapy (PDT) was used, with conflicting functional results.


A biopsy taken from the lesional skin revealed dilatation of intraepidermal eccrine ducts and a spongy appearance in the corneal layer (Fig. 3).


Symptoms and endoscopic lesions quickly regressed within 1 week of meloxicam withdrawal.


Carbamazepine-induced hyperammonemia.


In immunodeficiency conditions, unusual forms of leishmaniasis can develop and foster the risk of a diagnostic delay and of poor response to therapy.


We describe the safety and efficacy of enfuvirtide therapy in 4 patients with severe hemophilia A.


Terlipressin-induced ventricular arrhythmia.


Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy.


A 3-year-old boy diagnosed with acute lymphoblastic leukemia received induction chemotherapy.


The maximum tolerated single dose of intravenous iron infusion and iron pharmacokinetics are not known in children and not clear in adults.


We report a heart-lung transplant patient who developed chronic rejection (BOS stage 3) with the appearance of gross bronchiectasis on a spiral computed tomography (CT) chest scan.


A careful monitoring of the white blood count is obviously recommended.


Blood analysis revealed an elevated erythrocyte sedimentation rate and polyclonal hypergammaglobulinemia.


She was on etanercept and methotrexate for rheumatoid arthritis.


He had been receiving dobutamine 3 mug/kg/min by intermittent i.v. infusion over four hours once weekly as an outpatient.


A 57-year-old woman with end-stage kidney disease secondary to autosomal dominant polycystic kidney disease developed peritoneal dialysis-related Mucor peritonitis after her pet cockatoo bit through her transfer set.


Cultures became negative 10-37 days after the introduction of the drug.


Although, not included in the incidence calculation, four patients with CLL were referred at the time of development of AML/MDS.


The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine.


The main possible diagnoses, especially in the elderly, are age-related macular degeneration, tamoxifen and cancer-associated retinopathy (CAR).


First case of ivermectin-induced severe hepatitis.


The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.


Intravenous and subsequent long-term oral penicillin therapy was constituted and resulted in a significant decrease in the size of the pelvic mass.


Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature.


Aspergillus cholangitis can occur in the portoenterostomy patient and may be highly resistant to conventional therapy.


Asthmatic individuals are one of the higher risk groups suffering from dental erosion.


We describe a 35-year-old woman who developed severe thrombotic complications due to heparinization and unrecognized HDAs.


This confirmed the history of captopril-related asthma.


Septicemia and septic shock are a leading cause of morbidity and mortality among hospitalized patients.


Keratitis resolved within 8.4 weeks (range, 1-18 weeks) of treatment with fortified clarithromycin and amikacin.


The entire bezoar could be removed endoscopically.


Two months following LASIK, an epithelial dendritic lesion appeared in the lower third of the corneal flap of the left eye with vesiculoulcerative lesions of the lateral side of the tip of the nose.


PURPOSE: We report a case of a patient who developed a postoperative anterior spinal artery syndrome that was masked by the use of epidural analgesia.


After 5 days of treatment with IL-2, the patient developed a hemorrhagic lesion that progressed to toxic epidermal necrolysis, as well as grade 4 pancytopenia.


A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-beta therapy against malignant melanoma.


Nocardia keratitis was diagnosed from her culture results, and the species Nocardia exalbida was determined by phylogenetic studies using gene sequence analysis of 16S RNA.


To the best of our knowledge, although various abnormalities of bone due to retinoids have been described before, reversible sclerotic changes have not been reported.


Etanercept was not associated with a similar reactivation.


Stellate ganglion block is utilized in the diagnosis and management of various vascular disorders and sympathetically mediated pain in the upper extremity, head and neck.


We present a patient who developed spontaneous pulmonary hemorrhage during thrombolytic therapy.


Primary CNS lymphoma regressed on withdrawal of MM.


This study aims to explore SCs occurring without taste changes during chemotherapy, to better understand the characteristics of such changes, and how these experiences affect patients in their daily lives.


His physical examination, 2 weeks after the injection and during his follow-up revealed no abnormality.


As angiotensin-converting enzyme seems to play a role in the genesis and metabolism of bronchomotor mediators, this rare form of drug-induced asthma is important for both clinicians and airways pharmacologists.


CONCLUSIONS: Itraconazole-induced liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia.


METHODS: We identified three patients who developed skin necrosis and determined any factors, which put them at an increased risk of doing so.


Cerebral dural sinus thrombosis.


Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.


We report a patient with a colonic adenocarcinoma who developed hemolytic uremic syndrome after receiving 85 mg/m2 of the drug.


We detected proteinuria, serum cholesterol of 269 mg/dl, AST of 50 U/L, ALT of 41 U/L, serum total protein of 3.4 g/dl, serum albumin of 1.2 g/dl, positive cryoglobulin, and urine protein of 9.84 g/day.


There were several procedures suggested for the reconstruction.


Pulmonary veno-occlusive disease accompanied by microangiopathic hemolytic anemia 1 year after a second bone marrow transplantation for acute lymphoblastic leukemia.


Morphine-6-glucuronide is an active metabolite of morphine that has analgesic properties and is measurable in the plasma and cerebrospinal fluid of patients treated with this opioid.


Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.


The second had acute cystitis and was treated by sulphonamide and the third developed myopia coincident with metronidazole treatment for trichomonas vaginalis.


Although the outcome of this case was fortunate, this conservative treatment is unusual, and is not recommended as standard treatment.


Our patient developed both nephrogenic diabetes insipidus and renal tubular acidosis with a temporal pattern that demonstrated a link between foscarnet therapy and these abnormalities.


In the following days, fever, vomiting, hypertension and ARF occurred.


Pulmonary toxicity secondary to procarbazine.


Fatal acute tumor lysis syndrome with metastatic breast carcinoma.


Since amiodarone was first marketed in 1992 in Japan, the incidence of amiodarone-induced thyrotoxicosis (AIT) has been increasing.


The management of unresectable metastatic melanoma is a major clinical challenge because of the lack of reliably effective systemic therapies.


At the time of diagnosis, an esophageal fistula was observed and treated with cyanoacrylate.


5. At least half of the patients developing ANLL experienced long periods of significant cytopenia during therapy, often with documentation of bone marrow dysplasia.


DESIGN: Interventional case report.


In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.


This time the fever was accompanied by a diffuse erythematous skin rash that progressed to an extensive, full-body, desquamative skin rash.


A case of renal artery thrombosis attributable to umbilical artery catheterization, resulting in malignant renovascular hypertension, in a 15-day-old neonate, treated by catheter-directed thrombolysis through the involuting umbilical artery, was studied.


By x-ray microanalysis, gold that was complexed with sulfur was present in proximal tubular cytoplasmic vacuoles and nuclei.


Both cytoplasmic features of adaptation and nuclear alterations were noted in hepatocytes.


Whether valaciclovir (VCV) prophylaxis could be responsible for ganciclovir (GCV)-resistance of Human cytomegalovirus (HCMV) in transplantation has never been documented.


Several studies commented on the unanticipated symptom of increased sweating associated with hypoglycemia in diabetic patients who are taking beta-blockers.


One patient had a partial response ongoing at 17+ months on ipilimumab despite failure with four prior therapies, and the other two patients showed durable stable disease, both still ongoing at 17+ and 20+ months, respectively.


Inadvertent intramuscular administration of vincristine: lack of untoward effects without any treatment except administration of hot compresses.


Over the following months, he developed unusual symptoms involving the legs and genitourinary tract which, only after extensive investigations, were attributed to ischemic damage to the spinal cord related to the surgery.