To date, with a total of 1,103 patient-months of follow-up study, seven episodes of small intestinal obstruction have developed of which two were definitely and five possibly related to chemotherapy induced adhesion formation.


In lieu of an effective regimen, interleukin-2 (IL-2) and interferon alfa are considered drugs of choice to treat this cancer.


The cornea showed diffuse edema and a stromal ring infiltrate (disciform in appearance).


Despite antibiotic therapy, his pulmonary function deteriorated and 100 percent oxygen was required to maintain adequate oxygenation.


Since ethambutol is actively excreted via the renal system, compromise of renal function such as due to renal tuberculosis may lead to serum concentration elevations of ethambutol sufficient to produce optic neuropathy.


In-hospital management of adults who have community-acquired pneumonia.


She was otherwise healthy and did not complain of hyperhidrosis.


Role of Stellate ganglion block in post CABG sympathetically mediated chest pain.


The nephrotic syndrome cleared without steroid therapy and has not recurred 18 months later in one patient.


Here we describe two cases in postpneumonectomy patients in which expandable esophageal stent placement resulted in respiratory compromise requiring reintervention due to airway compression.


The patient was already on sodium valproate, and levetiracetam was given as add on therapy.


Renal sonogram showed hyperechogenic medullary papillae, which resolved during convalescence.


A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.


Nitrofurantoin-induced acute liver damage in pregnancy.


DISCUSSION: To our knowledge, this is the first case report illustrating neuralgic amyotrophy triggered by exposure to the antibiotics vancomycin, tobramycin, and piperacillin/tazobactam.


Lithium and ECT--concurrent use still demands attention: three case reports.


Amisulpride and sertraline were discontinued.


Superior sagittal sinus thrombosis associated with Evans' syndrome of haemolytic anaemia.


Hemolytic uremic syndrome following the infusion of oxaliplatin: case report.


Afterwards the thrombocyte count continuously decreased to normal values.


In the other patient, APL was diagnosed 46 months after liver transplantation for congenital biliary atresia.


Baseline laboratory studies to evaluate infertility had revealed normal hormonal levels.


L-asparaginase-provoked seizures as singular expression of central nervous toxicity.


Also, it appears that these patients may be more susceptible to complications with future disulfiram usage and should be strongly counseled to seek alternative therapies for their alcohol problems in the future.


Treatment with diuretics and catecholamine products showed almost complete recovery from CHF in 3 weeks.


We report on a patient with renal artery stenosis who had only 1 kidney and in whom acute renal impairment developed with transient anuria after the administration of captopril.


However, given the clinically significant result to the interaction between tolazoline and cimetidine we report, the use of cimetidine in tolazoline induced upper gastrointestinal hemorrhage should deserve more attention.


Tests for thyroid autoantibodies, as well as inhibitory and stimulatory antibodies, were negative, and fine needle aspiration biopsy revealed an adenomatous goiter.


Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed.


On day 12, the patient complained of dyspnea and cough.


The toxicity and plasma concentrations of ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide were then determined over 24 h after a single 1.6 g/m2 dose of ifosfamide.


IFN-alpha was continued in only one patient.


A 52-year-old man with neither congenital heart disease nor history of drug abuse had a spiking fever after dental treatment and was diagnosed with pneumonia at a local clinic.


INFVA is an important cause of pulmonary infections in patients receiving BMT, and is associated with considerable morbidity and mortality for a readily preventable and treatable infection.


TREATMENT AND OUTCOME: Exploratory surgery of the coelomic cavity was performed and the neoplasm was excised.


The acyclovir levels measured by radioimmunoassay were related to the level of consciousness.


Radiation was continued without chemotherapy.


These observations support the view of an increase in both the severity and incidence of PCP in patients without human immunodeficiency virus infection and question the need for a primary prophylaxis in patients with connective tissue diseases receiving high-dose corticosteroid therapy.


At laparotomy, the mass was located in the right broad ligament with a fibrous stalk connecting to the uterus.


In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.


We analyze a case of neutropenic enterocolitis which occurred in a patient with acute myeloid leukemia during chemotherapy and we suggest that, as well as intestinal wall thickness, hemodynamic worsening should be considered an indication for surgery.


We observed ventricular fibrillation in 2 patients who presented to the emergency department with pre-excited atrial fibrillation and were given 12 mg of adenosine.


FDE from cephalosporins has been rarely reported, and to the best of our knowledge there is no published report of ceftriaxone-induced FDE in the literature.


Mycophenolate mofetil is a non-nephrotoxic alternative which should be considered to rescue cyclosporine-dependent, severe myasthenia gravis sufferers with renal impairment from progression to end-stage renal failure.


rEpo was administered by i.v. injection three times a week for at least four weeks.


The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.


In addition, aggressive supportive measures to manage renal failure (hemodialysis) and labile hypertension, allowed this patient to have an extended survival as a result of successful therapy for this complication despite an underlying rapidly fatal malignancy.


Such might not be the case with newer technologies.


"Retinoic acid syndrome" was prevented with short-time treatment of high dose (4 x 1.5 g/m2) cytarabine.


OBJECTIVE: To describe what is believed, as of November 4, 2003, to be the first case published in the literature of acute interstitial nephritis (AIN) due to pantoprazole.


Children receiving zonisamide should be monitored for oligohidrosis and the development of neurological symptoms associated with an elevation of body temperature.


Fatal interstitial pneumonitis associated with docetaxel administration in a patient with hormone-refractory prostate cancer.


A water deprivation test demonstrated a nephrogenic diabetes insipidus.


Fever recurred 30 days after his initial presentation, and blood smear-positive vivax malaria was diagnosed.


Increasingly, the cytotoxic agent amifostine is being used prior to radiotherapy in an attempt to decrease associated morbidities.


Although the data indicate an immune-complex cause for gold-salt nephropathy, the incident antigen (or antigens) and mechanism of action remain unidentified.


The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.


Hepatopathy subsided after the cessation of carbamazepine and lynestrenol.


Such reactions have been described in patients receiving certain drugs such as 5-nitroimidazoles, nitrofurans, sulfonylureas and certain newer cephalosporins with a methyltetrazolethiol side chain.


In May 1996, as part of his routine antihepatitis B (hepB) vaccination plan, a 28-year-old HbsAg-negative man, hospital worker, received his first dose (20 microg) of a recombinant vaccine (EngerixB-B, Smith Kline and Beecham, Belgium), administered via deltoid injection.


One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol.


Post-influenza vaccine chronic inflammatory demyelinating polyneuropathy.


Diagnosis was made by serial blood glucose determinations during a 20- to 24-hour period after insulin administration.


RESULTS: The patient underwent anticoagulation therapy without removal of screw.


We present the first case of osteomyelitis in a patient receiving infliximab therapy for severe psoriasis and psoriatic arthritis.


He recovered without complications with imipenem-cilastatin prophylaxis.


Stupor from lamotrigine toxicity.


Acyclovir neurotoxicity: clinical experience and review of the literature.


The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction.


A 47-year-old woman received an allogeneic bone marrow infusion because of chronic myeloid leukemia.


The case history and toxicological findings of an infant fatality involving pseudoephedrine, brompheniramine, and dextromethorphan are presented.


In previous reports, three of four patients with TSHoma displayed Graves' disease after tumor resection, and TSH is also known to play a major role in regulating immunomodulatory gene expression in thyrocytes.


After five and six weeks of continuous oral administration of methylprednisolone, the boys developed steroid diabetes.


Severe chronic active Epstein-Barr virus infection is a rare, debilitating, nonneoplastic, inflammatory disorder for which there is no definitive treatment.


Evaluation revealed CMV viremia with a high viral load and CMV gastritis was confirmed using gastroscopy and histopathologic examination.


A 40-year-old woman presented with an unusual form of corneal herpetic reactivation 5 weeks after laser in situ keratomileusis.


There is no consensus on the treatment of ticlopidine-induced marrow aplasia.


The activity of the circulating anticoagulant and the BFP disappeared within days following discontinuation of procainamide and the administration of corticosteroids.


The long P-P intervals ranged between 1.04-1.12 s and the short P-P intervals between 0.80-0.84 s, respectively.


Orthostatic hypotension and vertigo are not consistent with the patients' histories.


Nonsurgical management of ectopic pregnancy associated with severe hyperstimulation syndrome.


Ciprofloxacin-induced hemorrhagic vasculitis.


Pemphigus vulgaris is a rare auto-immune blistering disease that can also be life-threatening.


Subcutaneous IL-2 is safe and well tolerated, with a mortality rate <3%.


Clinical presentation spreads from almost asymptomatic patients to critically ill patients with pulmonary oedema or frank cardiogenic shock.


All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis.


Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE).


In some cases this seems to happen because spironolactone causes diarrhoea.


Kaposi's sarcoma (KS) is an unusual tumor principally affecting the skin of the lower extremities.


However, prolongation of 5-FU half-life and an increase in INR have been reported with the concurrent use of 5-FU and warfarin.


The patient had a history of environmental allergies.


Optimal medical management may not be widely recognized.


The TC occurred in the absence of hyperparathyroidism or a high calcium x phosphate product as evidenced by hormonal and biochemical examination as well as by a bone biopsy specimen that revealed an adynamic bone disease with significant aluminum staining.


A 2-year-old mentally retarded boy with frontal lobe epilepsy presented with an episode that resembled heat stroke during the administration of zonisamide.


In a prospective study, we found that 10 of 19 diabetic patients (53%) who had received insulin containing insulin also had high levels of antiprotamine immunoglobulin E.


We present a report summarizing our experience and problems with six patients who had a clinical picture of NE and offer a short review of the current literature on the subject.


Diphenhydramine, a common ingredient in over-the-counter medications, is often taken in overdose.


A 36-year-old white man had both acute intermittent porphyria and long-standing idiopathic grand mal seizures.


Female renal allograft recipients who develop CMV infection during pregnancy are at risk for both graft dysfunction and fetal morbidity.


Twenty-four-hour ambulatory pH monitoring demonstrated decreased acid reflux 8 weeks after withdrawal of nifedipine, with coincidental symptomatic and endoscopic improvement.


We report a case of exfoliative dermatitis clearly linked to intravenous and intraperitoneal administration of tobramycin.


By the 10th ICU day, the patient's respiratory and mental status improved and the patient was successfully extubated.


Investigations confirmed a leucopenia and neutropenia.


Serologic evaluations on presentation ruled out infectious diseases or other etiological factors.


CONCLUSIONS: The use of IL-2 in bedridden patients with performance status >2 must be given on an individualized basis.


CONCLUSIONS: When central nervous system findings are observed in renal transplant recipients, nocardial brain abscess must be considered in the differential diagnosis.


Depending upon the severity of the exacerbation and the type of organ involvement, reactivation of sarcoidosis may require discontinuation of the interferon therapy, with or without the use of additional steroids.


Class effect of erythropoietin therapy on hemoglobin A(1c) in a patient with diabetes mellitus and chronic kidney disease not undergoing hemodialysis.


Pathologic specimens obtained by open lung biopsy showed thickening of the wall from the distal bronchioli to the alveolar ducts due to submucosal and intraepithelial infiltration of lymphocytes, histiocytes and foamy macrophages, which was not accompanied by organizing changes.


Hepatitis B virus reactivation in a patient undergoing steroid-free chemotherapy.


To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.


The children who received appropriate therapy had a favorable outcome.


Bone marrow or stem cell transplantation is an established therapy for haematological malignancies.


We describe a possible drug interaction between these two drugs and recommend that they should only be used together with caution.


Despite appropriate therapy, the microangiopathic process was irreversible and the patient died.


We report on three patients with acute schizophrenia, who developed severe akathisia during treatment with olanzapine (20-25 mg/d).


Experience in the current case suggests that preventive measures for tumor lysis syndrome, including allopurinol and hydration, should be taken for patients with high leukemia burden who receive imatinib therapy, and parameters of tumor lysis should be monitored in the early phase of therapy.


With the use of the newer antidepressants beyond the traditional tricyclics and monoamine oxidase inhibitors, newer options in headache prophylaxis are provided as well as the potential for undesirable and even potentially life-threatening interactions between medications.


Diagnosis was confirmed by polymerase chain reaction (PCR) detection of donor DNA in the patient, by amplification of Y-chromosome sequence and analysis of minisatellite polymorphisms.


BACKGROUND: Although most patients receiving insulin produce insulin-specific IgE, significant allergic symptoms develop in very few of them.


Observations in our patient suggest that the leukoencephalopathy that developed in previously reported patients who received 5-fluorouracil and levamisole may have been caused at least partly by levamisole.


The implications for the long-term effects of phenelzine treatment are considered.


Nimesulide should be added to the list of agents associated with this serious adverse drug reaction.


A 19-year-old woman was admitted with acute severe asthma in her eleventh week of pregnancy.


The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.


MCD was steroid-resistant type.


Cancer patients with decreased DPD activity are at increased risk for severe toxicity including diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity, and, in some cases, death.


The patient had a history of alcohol abuse; alcohol intake as well as withdrawal can also cause seizures.


The results in this case suggest that cyclosporin is an effective agent in patients with severe sight threatening Mooren's ulcer.


Weakness of the right arm, focal seizures, lethargy and confusion appeared on day 10.


An indirect immunofluorescence test for ANCA was positive.


A case of a 21-year-old woman who had developed mild hepatotoxicity while receiving choline magnesium trisalicylate therapy is described.


A 600-mg loading dose appears to shorten the time to achieve an adequate antiplatelet effect to about two hours.


However, the thrombocytosis did not resolve.


Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates.


RESULTS: The 3 patients were men, aged 39, 42, and 43 years.


Biopsy specimens from the oral mucosa and forearm revealed small brown-black granules scattered in the dermis and basal lamina of eccrine sweat glands, blood vessels, and hair follicles under the light microscope.


Hypersexuality with antiparkinsonian therapy.


He was transferred when he developed pancytopenia, fever, severe mucositis, ileus and peripheral neuropathy.


Perilesional linear atrophic streaks associated with intralesional corticosteroid injections in a psoriatic plaque.


CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.


The dermatology literature heretofore has not noted that anemia is a side effect of patients taking MMF to treat pemphigus.


Consequently, the treatment was immediately stopped.


A causal relationship between high doses of thyroid hormone and the presumptive impairment of endogenous TRH reserve is suggested.


The paper discusses the imputability of benfluorex, a drug used as an adjuvant in hypercholesterolemia, structurally related to amphetamines.


We describe the clinical response, as determined by increases in total Hb and decreased transfusion needs, in five patients with thalassemia intermedia treated with HU alone or in combination with SPB.


Three patients (five eyes) with intraocular lymphoma were also treated with a 1 mg injection of rituximab.


We present a case of the syndrome of inappropriate antidiuretic hormone (SIADH) secondary to cisplatin therapy in a patient with advanced-stage large cell neuroendocrine carcinoma of the cervix.


Positive reaction were obtained to captopril at 4 days and the others test being negative.


Some patients develop hypersensitivity rash in response to HCQ.


Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.


Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.


Following 7 days of tigecycline she developed severe abdominal pain and elevated pancreatic enzymes suggesting acute pancreatitis.


A 32-year-old white woman with major depression was treated with venlafaxine for 3 years.


Anesthesiologists and surgeons should be aware of this uncommon complication than can occur with the use of peritonsillar bupivacaine infiltration for pain control in tonsil surgery.


The degree of emanating clinical events also conforms to status of the aflatoxicosis.


To our knowledge, this case report represents only the third description of laxative-induced TEN.


KW-2149 is a new, semisynthetic, C-7-N-substituted, mitomycin C (MMC) analog showing equal or superior antitumor activity in both in vitro and in vivo assays.


We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.


Long-acting somatostatin analogues such as SMS 201-995 (Sandoz) are being evaluated in a wide range of clinical indications, including gut neuroendocrine tumours and acrogemaly.


Real-time ultrasound imaging prevented inadvertent injury to the esophagus as well as the thyroid gland and vessels.


Four of the six experienced renal failure requiring dialysis.


He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil.


Patients who developed this syndrome did not differ from other patients in baseline ratings on the Brief Psychiatric Rating Scale (BPRS) and the Scale for the Assessment of Negative Symptoms, except that patients who developed the syndrome had a significantly higher mean baseline rating on the BPRS anxiety subscale.


Diabetic symptoms dominated the clinical presentation but there was no tendency towards diabetic ketoacidosis.


Mineral oil, a hydrocarbon, may not elicit a normal protective cough reflex and may impair mucociliary transport.


Chlorpropamide-induced hemolytic anemia.


Well-fixed metal-metal hip resurfacing components are removed for infection, instability, or hypersensitivity reactions.


In patients with swallowing dysfunction and pneumonia, a history of mineral oil use should be obtained and a diagnosis of ELP should be considered in the differential diagnoses if mineral oil use has occurred.


Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.


CONCLUSION: Our investigations indicated that oxaliplatin interacted with both an IgG antibody and a RBC membrane epitope probably located on the Band 3 anion channel.


The mechanism, causes, and significance of disulfiram-like reactions are discussed.


The increasing number of Latinos in the United States and the extensive cross-border transfer of medicines raise concerns that metamizole use and associated complications may become more frequent.


The authors describe a case of valvular heart disease in a 48-year-old woman receiving benfluorex (150 mg t.i.d. for 8 years) and leading to surgical mitral valve replacement.


We consider that the MAHA in this patient is chemotherapy-related.


A woman who had a deep scar on her left arm as a result of an influenza vaccination was treated with insulin.


Neither a complication nor clinical or radiological sequelae occurred in this patient.


Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts.


This finding suggests that conversion of ischemic to hemorrhagic infarction may occur even with appropriate and carefully administered anticoagulation therapy.


A 77-year-old man developed ankle, hand, and facial swelling 2 weeks after starting rosiglitazone.


A search of the United States Food and Drug Administration's Adverse Event Reporting System identified nine cases of oxcarbazepine-associated angioedema in pediatric patients aged 16 years and younger.


Fluconazole in the treatment of candida peritonitis in continuous ambulatory peritoneal dialysis: report of a case.


By the time of treatment stabilization, the patient had not experienced any further fits.


Disopyramide-induced heart block.


These finding indicate the possibility that the ileus was triggered by drugs with anticholinergic properties in this elderly diabetic patient treated with alpha-glucosidase inhibitors.


Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.


The 5 neonates with antral hyperplasia had received prostaglandin E1 for longer periods (mean [+/- SD] duration, 569 +/- 341 hours) than the 65 normal neonates (54 +/- 58 hours, P less than 0.001) or the 4 neonates with clinical signs of gastric obstruction (119 +/- 60 hours, P less than 0.05).


In this case, discontinuing piroxicam, a nonsteroidal anti-inflammatory drug, and starting a palliative treatment plan helped resolve a patient's ulcers.


Allergy to cloxacillin with normal tolerance to amoxicillin and cefuroxime.


Median performance status (SWOG) was 2 (1 to 3), and clinical presentations included nephrotic syndrome (n = 1), symptomatic cardiomyopathy (n = 1), gastrointestinal involvement with polyneuropathy (n = 2), and hepatomegaly (n = 1).


Pentacam analysis may serve as a useful adjunct in following the progression of herpetic reactivation cases.


Intra-arterial adriamycin chemotherapy for bladder cancer.


OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.


Neuroleptic malignant syndrome is easily confused with other health problems; distinctions between it and malignant hyperthermia, heatstroke, and lethal catatonia are made.


There was only a short term exposure to classic antipsychotics prior to risperidone administration.


The seizures started when he was 2 months old.


PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.


In patients with metastatic disease who had high levels of gastrin, SMS treatment for 5 to 24 months did not inhibit tumor growth or decrease gastrin levels.


The incidence of cerebral amyloid angiopathy increases with advancing age.


More than 4 years later, the patient continues to be troubled by persistent paraparesis and chronic pain.


Selective catheterization of the tumor vessels is the established standard in TACE.


Pulmonary infiltrates and skin pigmentation associated with sulfasalazine.


OBJECTIVES: To present a very rare case of orally ingested sex hormone pills inducing nondurally attached meningioma in the lumbosacral region.


The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.


One of the antimalarials which has been highlighted for its effectiveness is halofantrine.


Shortly after chemotherapy and an injection of pegfilgrastim, the patient developed poorly defined, rapidly progressive erythema, edema, and pain in his right forearm.


A patient developed restless legs symptoms paralleling the course of interferon-alpha (IFN alpha) therapy for chronic hepatitis C.


The authors describe a case of interstitial granulomatous dermatitis associated with darifenacin.


Despite the lowest plasma osmolality, detectable levels of circulating ADH were present.


Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.


We report the case of a 40-year-old woman who developed fulminant hepatic failure and aplastic anaemia following a course of oral flucloxacillin.


Patients treated with L-asparaginase may present with hemorrhagic and thrombotic cerebrovascular events.


The patient then suffered from sudden left chest pain and dyspnea.


Medical or surgical therapy is variably successful in these men.


The group mean Karnofsky score increased from 76 before to 86.6 after therapy, indicating that with r-HuEPO treatment subjects were able to exert themselves to perform ordinary activities.


Clinical effects from accumulation of morphine-6-glucuronide have not been described with the exception of case reports in which patients with renal failure were noted to develop opioid toxicity with high plasma levels of the metabolite and low levels of the parent drug.


This case suggests that acute pancreatitis was due to intolerance of high-concentration lipid emulsion.


White clot syndrome and continuous arteriovenous haemofiltration.


Shortly after mizoribin withdrawal, his serum Na increased significantly from 128 to 139 mEq/l and plasma osmolality from 265 to 287 mosm/kg.


RESULTS: Four patients experienced ventricular free wall rupture after having a MI between November 17, 1993, and July 28, 1995.


The application of PCR-Restriction Enzyme Analysis (REA) method on cutaneous specimens in veterinary medicine is an extremely interesting diagnostic tool.


We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV-associated lymphoproliferative disease.


And the importance of instituting prompt diagnosis and proper treatment should also be stressed.


CASE REPORT: 1.5 years after resection, hyperfractionated radiotherapy and chemotherapy of an anaplastic ependymoma in the right parietal region, the cranial MRI of an 11-year-old girl showed multiple small contrast-enhanced lesions in the frontal cortex.


Previous reports of warfarin resistance implicated older enteral feeding products with a much higher vitamin K content.


BAL fluid also grew Mycobacterium kansasii, for which he received combination anti-mycobacterial therapy.


The patient was otherwise healthy and taking no medication.


CONCLUSION: Although BCG is considered a very effective treatment; consensus exists that not every patient with superficial bladder cancer should be treated with BCG due to its increased risk of toxicity.


10 months later all studied cells in the marrow contained this deletion.


CONCLUSION: We conclude that stanozolol is a safe and effective treatment of the cutaneous manifestations of cryofibrinogenemia.


We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.


With a single 0.2 mg/kg dose of rasburicase, the serum urate level normalized and the infant completed therapy without incident.


CONCLUSIONS: This is the first report of occurrence of scleromyxedema in a patient with MS.


Clinical improvement has outlasted suppression of VIP secretion (suggesting an additional direct antisecretory action of SMS 201-995) and has occurred despite expansion of hepatic metastases.


Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.


A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).


Eight cases of pellagra, diagnosed on the grounds of neuropathological findings and retrospective study of clinical data, were found among 106 necropsy cases of tuberculosis.


We report a case of reversible DKA and new-onset DM that developed in a demented patient who was treated with quetiapine for 14 days.


We present a unique case of extensive BRONJ involving the maxilla, sinuses, and skull base, complicated by sinusitis and an intracranial abscess.


This is the first case of HBV reactivation occurring during the year following rituximab monotherapy in the absence of any other immunosuppressive factor.


RESULTS: Disconnection or damage of the catheter leading to leakage of baclofen into the lumbar swelling could be ruled out by the use of an indium (111) DTPA flow study.


The probable additive toxicity of both agents on the pulmonary tissue is discussed.


Hence, desensitization would be essential and may be accomplished successfully using the protocol described in this report.


In many cases neutropenic enterocolitis is confined to the cecum, but the entire colon is sometimes involved.


Recurrent Listeria monocytogenes bacteraemia in a liver transplant patient.


CASE: A multipara with a twin gestation presented with premature labor at 31 weeks.


Recommendations that may help prevent these adverse systemic effects in premature infants include: (1) avoidance of excess subconjunctival anesthetic doses, (2) preoperative administration of systemic atropine to minimize the oculocardiac reflex, (3) consideration of an analgesic agent to decrease the pain and exhaustion, and (4) cardiorespiratory monitoring in a hospital setting, with an intravenous line in place, at the time of treatment.


Potential predisposing factors.


The potential occurrence of EMD in all three patients raises the possibility of accelerated myocardial rupture, as EMD is one of the clinical hallmarks of this condition.


In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage.


The clinical course suggests that caffeine, which is present in oolong tea, was mainly responsible for the rhabdomyolysis as well as the delirium, although severe hyponatremia has been reported to cause rhabdomyolysis on rare occasions.


Finding an effective therapy for this subgroup of patients with severe recurrent HCV is a priority.


CONCLUSION: The combination of FSGS with leukemia poses a management challenge to the clinician in terms of further treatment with potentially nephrotoxic drugs, complications of nephrotic syndrome (including infections), and timing of renal transplantation.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


When vague symptoms develop during desmopressin therapy, hyponatremia must be considered as part of the differential diagnosis.


Itraconazole-related increased vincristine neurotoxicity: case report and review of literature.


Imatinib mesylate (Gleevec) is widely-used in the treatment of chronic myeloid leukaemia (CML) and gastrointestinal stromal tumour.


Nimodipine: evidence for clinically significant gastrointestinal side-effects.


Craniotomy was performed in one of these patients to control the hemorrhage; in the other three, 0.5 to 2 cc of thrombin (5000 U/cc) was slowly injected via the biopsy cannula, resulting in immediate control of bleeding in all three cases.


Patients must be instructed to recognize early symptoms of this severe infection and call the surgeon immediately.


Bronchoscopy with BAL can be successful in establishing the diagnosis of ELP by demonstration of a high lipid-laden macrophage index.


Patient 1 had an arterial thrombosis, whereas Patient 2 had a venous thrombosis.


With this initial therapy we have had no treatment failures.


A significant number of Asians reside in Australia, and consequently patients with nasopharyngeal carcinoma are an increasing clinical problem.


The case of a 65-year-old male migraine patient with spontaneous internal carotid artery dissection is presented.


Topical capsaicin as an adjuvant analgesic for the treatment of traumatic amputee neurogenic residual limb pain.


The ECG at the onset of CHB suggested block to have occurred in the trifascicular conduction system.


It is present in approximately 2% of the population and is estimated to cause symptoms<5% of the time.


This case report describes two patients with acute obstetric disseminated intravascular coagulation in whom the use of heparin resulted in marked clinical improvement.


Both patients developed cardiogenic shock and were treated unsuccessfully with thrombolysis.


Neonates present with an immature physiology and biochemistry with respect to drug metabolism.


A maculopapular rash and a fever developed 2 weeks later.


Only few reports exist on iodine-induced hypothyroidism after a single injection of the iodized radiopaque dye Lipiodol.


At 8 years 1 month of age, phenytoin was first administered.


Because conservative therapy was not helpful for spinal stenosis and neuroclaudication, a left L2 transforaminal epidural injection was attempted, but a posterolateral fusion mass made this procedure impossible.


Other case reports of second malignant neoplasms (SMN) following acute leukemia are cited; available data suggest that the overall risk of SMN in AML may be in the range of 6%.


One plausible explanation is HSV reactivation secondary to localized immunosuppression from corticosteroid injection.


The allopurinol hypersensitivity syndrome is a rare adverse drug reaction.


Our search of the literature found no published pediatric pharmacokinetic data.


CONCLUSION: It is critical that oncologists remember that the theoretical benefits of available anti-neoplastic interventions must be carefully and constantly weighted against the potential harm they may cause.


Except hypothyroidism after radioiodine treatment (euthyroid under substitutional therapy), she suffered from no other diseases.


The induced hyperglycaemia could not be controlled sufficiently, despite a high dose of insulin (> 110 units/day), suggesting the existence of insulin insensitivity and hyperinsulinaemia.


According to the Naranjo adverse drug reaction probability scale, the likelihood that temozolomide was responsible for the adverse drug reaction of fever was probable (score of 6).


The infiltrate was treated with a combination of topical polyhexamethylene biguanide, chlorhexidine, atropine sulfate, and oral itraconazole and resolved within 2 months.


Two cases of toxic reaction to lithium carbonate are reported.


A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure.


While this report is anecdotal, any new drug warrants intense monitoring for unexpected toxicities in the post-marketing period.


Botulinum therapy was discontinued and nonsteroidal anti-inflammatory medication markedly reduced the new symptoms, which completely resolved within 3 months.


Twenty-four hours after the administration of gemcitabine, a symmetric, bullous, herpetiform eruption appeared on his trunk and upper limbs.


The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.


A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year-old woman.


Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies.


Simvastatin-induced rhabdomyolysis following cyclosporine treatment for uveitis.


The clinical and allergologic features of this case strongly suggest type IV hypersensitivity.


This fatal complication occurred despite a careful selection of the patient and the presence of a lytic state.


OBJECTIVE: This case study provides practical information for general practitioners in the detection, assessment and management of patients with cough mixture opioid dependence.


We suggest that irinotecan offers an effective treatment option for children with recurrent brain stem glioma and other genetic variants except UGT1A1 may be a risk factor for irinotecan-induced toxicity.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


Concurrent use of warfarin and 5-fluorouracil has resulted in elevated international normalized ratios (INRs).


The nephrotic syndrome developed in a patient receiving therapy with gold for rheumatoid arthritis.


Induction of glycosuria and hyperglycemia by topical corticosteroid therapy.


Excluding other causes, Pentasa-associated pancytopenia was considered.


Familiarity with and critical appraisal of the literature on pulmonary infiltration in immunocompromised patients can contribute to a clear diagnostic and management plan.


Adverse effects are typically limited to treatment site erythema and erosion.


She subsequently survived despite the development of convulsions, severe lactic acidosis (pH 6.86), hyperthermia (Temp 40.5 degrees C) and rhabdomyolysis.


Recombinant human interferon-alpha has been used in the treatment of several cancers, but there have been several reports that it may exacerbate psoriasis or trigger off its onset.


This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.


In all three cases, an alleviation of headache intensity from severe to moderate was observed.


Aggressive management of doxorubicin-induced cardiomyopathy associated with 'low' doses of doxorubicin.


After 3 months of pharmacological wash out, patient become pregnant and manifested this severe malformation.


Acute leukopenia associated with silver sulfadiazine therapy.


Blood findings during blast transformation were heterogeneous, including normal blood morphologic findings in 1 patient, leukocytosis with circulating blasts and basophilia in 1, and marked pancytopenia in 1.


On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.


One patient required urgent liver transplantation for fulminant hepatic failure after the brief use of black cohosh.


We report the spectrum of ocular toxicity following accidental inoculation of latex of Calotropis procera (Sodom apple) in 29 eyes between January 2003 and December 2006.


Arterial hypertension associated with topical ocular use of phenylephrine in dogs.


We diagnosed this case as danazol induced thrombocytopenia.


PURPOSE: To report a case of traumatic flap dehiscence and Enterobacter keratitis 34 months after LASIK.


Despite surgery and combination therapy with voriconazole, caspofungin, and terbinafine, the patient died 8 months after transplantation.


Rush disease, or aggressive posterior ROP (AP-ROP), progresses rapidly to stage 5 disease without exhibiting the classical course that includes stages 1-3.


Clofazimine induced nail changes.


This case illustrates the potential decoupling of PSA response from disease status in flutamide withdrawal.


Failure of intravenous ribavirin in the treatment of invasive adenovirus infection following allogeneic bone marrow transplantation: a case report.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


New onset diabetes mellitus (DM) and diabetic ketoacidosis (DKA) among patients using atypical antipsychotics is of clinical importance [1,2,5,7-10].


Capecitabine 1500 mg taken by mouth twice daily was prescribed as the salvage chemotherapy.


However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.


Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.


Catheterization revealed 90% midstenosis of the left anterior descending artery, which was successfully treated with percutaneous transluminal coronary angioplasty (PTCA) and stent placement.


Although myelosuppression is mild, immunosuppression and superinfection are potential hazards of treatment with DCF.


This was treated immediately with oral acyclovir.


CONCLUSIONS: Intravitreal injection of triamcinolone is a commonly performed treatment for many retinal conditions.


In addition, the deletion of chromosome no. 20, described as characteristic for PV, was found in 3 cells.


The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.


Chymopapain is a useful drug when used properly for lumbar disc disease and has the potential of eliminating three-fourths of lumbar disc surgery.


Hypoglycemia induced by long-acting somatostatin analogues in a patient with nonfunctional neuroendocrine tumor.


Fever, pulmonary infiltrates, and pleural effusion following acyclovir therapy for herpes zoster ophthalmicus.


The association with etanercept therapy and granulomatous reactions is discussed along with the differential diagnosis.


The rebound phenomenon in which HBV proliferates abruptly has not been experienced after withdrawal of lamivudine.


We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia.


Rebound headache after withdrawal of ergot alkaloids may lead to self-medication and overdosage, with subsequent risk of ergotism.


After the patient underwent conservative treatment, the new symptoms resolved, and follow-up MR imaging and computed tomography demonstrated resorption of the epidural air in the lumbar region.


Hormone therapy with leuprolide acetate (Lupron) is frequently used to treat prostate cancer, a common malignancy expected to be diagnosed in >180,000 men in the United States this year.


Low serum Na+ and hypoosmolality in the absence of volume depletion, clinically manifest edema, and unaltered renal, adrenal, cardiac, or thyroid function suggest that this antiarrhythmic drug produced the syndrome of inappropriate antidiuretic hormone secretion (SIADH).


Acute colonic diverticular perforation presenting as left ear pain and facial swelling due to cervical subcutaneous emphysema in a patient administered corticosteroids.


Patients completing the trial were eligible to receive rhEPO as part of an open-label study.


The test, using peritoneal dialysis fluid, was positive for Streptococcus epidermidis.


Biopsied muscle pathology indicated the presence of neurogenic muscular atrophy in combination with corticosteroid myopathy.


Mechanisms, including 5-HT2A and 5-HT2C antagonism, serotonergic regulation of dopamine systems and putative dopaminergic subtypes of OCS and OCD, are discussed.


Squamous cell carcinoma.


Parenteral pyridoxine, the specific antidote for INH-induced refractory seizures, should be readily available in every emergency department in the areas similarly experiencing increasing trends of TB.


Instead, she referred an improvement with gonadotropin releasing hormone agonist (GnRH-a) for the treatment of endometriosis and then with tamoxifen as hormonal therapy after mastectomy and chemotherapy for breast cancer.


We report the first case of IHA associated with cefuroxime administration.


The child had a history of heart disease treated with digoxin.


The management of genitourinary malacoplakia in renal transplant recipients has been unsatisfactory previously, as evidenced by an unacceptably high rate of graft loss and mortality.


She received an alcohol-containing tylenol elixir while receiving the drug on two occasions.


Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase gamma (POLG1).


A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.


Valproate-induced hyperammonemia as a cause of altered mental status.


The thyrotropin (TSH) level was normal before IFN-alpha was started.


Two cases illustrate how analeptic abuse can contribute to the development of paranoid psychosis in narcolepsy and greatly complicate treatment.


We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.


A case of skeletal fluorosis induced by prolonged treatment with niflumic acid, a fast-acting non-steroid antiinflammatory agent, is reported in a 35-year-old woman suffering from rheumatoid arthritis and treated, in addition, with corticosteroids.


To our knowledge, we describe the first reported case of isolated paresthesia and peripheral neuropathy, without systemic involvement, secondary to sulindac administration.


Infectious toxicity of dexamethasone during all remission-induction chemotherapy: report of two cases and literature review.


Radiotherapy is the mainstay of treatment for early nasopharyngeal cancer, but combination chemoradiotherapy is becoming more common for patients with advanced disease since the Intergroup trial 0099 demonstrated improved progression-free survival and overall survival for chemoradiotherapy.


Pharmacotherapy with tricyclic antidepressants, anticonvulsants, tramadol and traditional analgesics had failed, primarily due to adverse drug effects, particularly sedation, dizziness and nausea.


The ectopic pregnancy was completely resolved with two doses of methotrexate administration.


Radiation recall refers to inflammatory reactions triggered by chemotherapeutic agents and develops cutaneously in the previously irradiated areas.


Acute rehabilitation was complicated by a large defect of the abdominal wall and significant critical illness polyneuropathy.


The major features of akinetic-rigid syndromes are bradykinesia (small, slow movements), rigidity and tremor, often summarised as "parkinsonism".


To our knowledge, our report is one of the first on shock and angio-oedema from irbesartan.


Treatment of caffeine toxicity with esmolol.


On the second occasion she developed a very severe episode of hypotension followed by the outbreak of a generalised rash during general anaesthesia.


Hyperammonemia has been described as a complication of valproic acid therapy but may often be overlooked as a cause of lethargy in the postictal patient who presents to the emergency department.


Up to four percent of patients treated with imatinib may develop hepatotoxicity, which usually resolves with discontinuation of the drug.


The central nervous system (CNS) is the major organ system affected, although the renal, gastrointestinal (GI), endocrine, and cardiovascular (CV) systems also may be involved.


The conditions of three children with dermatomyositis and one child with polymyositis were treated for nine to 31 months with combined prednisone and intravenous methotrexate (1 mg/kg/wk) when prednisone alone was ineffective in controlling the disease or when there were substantial steroid-related toxic effects.


This may indicate that the anticonvulsive drug affected the vermis and flocculonodular lobe much more than the hemisphere of cerebellum, or that the cerebellar system sign in verminal and flocculonodular lobe lesion and its connection is detected more easily than the hemispheric lesion with the aid of a neuro-otological examination.


Fulminant hepatic failure developed in a 24-year-old black woman who had been treated with propylthiouracil and propranolol for hyperthyroidism.


Herbal medicine causing likely strychnine poisoning.


A manual pumping test is commonly used to verify the patency of a ventriculoperitoneal (V-P) shunt.


The clinical findings and laboratory studies suggested an autoimmune cell-mediated hypersensitivity reaction triggered by phenobarbital.


We report marked QT prolongation and torsades de pointes in a setting of flash pulmonary edema resulting from acute myocardial ischemia in a patient who was being treated with dofetilide for atrial fibrillation.


We have cared for three children in whom four episodes of dystonia proceeding to opisthotonus occurred in association with carbamazepine use.


The temporal sequence of the respiratory insufficiency and the histopathology, when compared to the previous examples in the literature, suggest that cyclophosphamide was aetiologically responsible for the lung disease.


In the case of foul drainage, burn reconstruction would be delayed.


Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.


A drug interaction between zafirlukast and theophylline.


In 1993, a case of PI with nephrotic syndrome following steroid treatment was reported in Japan.


Successful treatment with multiple intra-articular injections of infliximab in a patient with psoriatic arthritis.


Similar phenomena have also been observed with other antibiotics.


OBJECTIVE: To report a case of angioedema associated with losartan administration.


Both patients deteriorated during treatment with propranolol, and became asymptomatic during treatment with verapamil with normal graded exercise tests.


CONCLUSIONS: The observation that neurotoxicity developed with a delay of 24 to 48 hours after acyclovir peak serum concentrations could explain the wide range of acyclovir levels reported in similar cases.


Acute non-lymphocytic leukemia occurred in eight women following long-term treatment with Treosulfan (= dihydroxybusulfan) for ovarian carcinoma.


In half of the above cases, symptoms resolved without the use of antipsychotics.


A medical evaluation for an alternative etiology of his seizures was negative.


In patients with recurrent malignant glioma, treatment-related myelodysplastic syndrome (t-MDS) and acute leukemia are rare adverse effects because the median survival after relapse is limited.


The pathophysiological mechanisms remain unknown, although the drug could act through massive cytokines liberation after destruction of CD20 positive cells by rituximab.


There have been few reports, however, which have investigated a challenge with clozapine in patients previously showing eosinophilia.


After clinically evident necrosis developed, prompt surgical debridement was carried out.


PURPOSE: To report new indocyanine green angiographic (ICGA) findings after intravitreal bevacizumab (IVB) for myopic choroidal neovascularization (mCNV).


TMP/SMX is primarily used for the treatment of pneumocystis carinii pneumonia prophylaxis in AIDS patients.


RESULTS: The panuveitis and retinal periphlebitis began to resolve within one week; however, ten days after the last corticosteroid dose, the patient was hospitalized with the diagnosis of cerebral venous thrombosis.


Cerebral demyelinating disease developed in a patient during adjuvant therapy with levamisole for malignant melanoma.


Rhabdomyolysis associated with the use of intravenous vasopressin.


These may not always be reported in the literature.


Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment.


OBJECTIVE: We report a case of cutaneous KS lesions in a patient affected by CML treated with imatinib.


Despite anti-tuberculous treatment, she died on day 85.


Disulfiram has been used effectively to deter alcohol consumption in patients with a history of alcohol abuse.


Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case.


In patients with swallowing dysfunction and pneumonia, a history of mineral oil use should be obtained and a diagnosis of ELP should be considered in the differential diagnoses if mineral oil use has occurred.


Delay of corneal wound healing in patients treated with colchicine.


20% of the reported cases of t(8;16)(p11;p13) AML are therapy-related and this case further supports the possible role of the ionizing radiation in the development of this disorder.


The patient's status as a probationer or parolee played a pivotal role in strategies for ensuring treatment through the criminal justice system as opposed to the mental health system or civil commitment process.


A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).


A pulmonary embolus and hepatic and renal infarcts were then found.


When venlafaxine treatment was begun, their ocular pressure was steadily around 17-18 mmHg.


We also discuss the possible contribution of altered cerebrospinal fluid dynamics in the development of leukoencephalopathy.


This would suggest that botulinum toxin is a safe and effective first line treatment for palatal tremor.


Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inherited disease which may comprise many endocrine and non-endocrine components.


The diagnosis of BOOP requires the presence of a combination of pathological, clinical, and radiological features.


It is not possible to ascribe these improvements specifically to plasmapheresis since the patient was concurrently receiving low doses of prednisone and intermittent treatment with cyclophosphamide.


There was neither a rise in haemoglobin nor a reduction in transfusion dependence in any of the other patients.


Epidural steroid injection resulting in epidural hematoma in a patient despite strict adherence to anticoagulation guidelines.


Clinical cases documenting the development of pemphigus in patients with a history of psoriasis have been reported in the literature.


Whether the drug is unmasking latent autoimmune hepatitis is unclear.


Nevertheless the patient lapsed into a hypotonic coma.


Moreover, little information on the management of this easily recurring disease is available at present.


The dog developed generalized lower motor neuron paralysis, with generalized hyperesthesia, myoglobinuria, and high serum muscle enzyme activities.


The development of lymphoma in the gastric stump is rare.


Subjective complaints decreased, and best-corrected Snellen visual acuity improved with topical corticosteroid therapy alone.


The above-mentioned second malignancy is one of the late sequelae of platinum-based chemoradiation.


The victim was released from hospital the next day.


These patients showed slightly low serum calcium, normal or low serum phosphate, and normal parathyroid hormone concentrations.


He was treated with oral ibuprofen 600 mg every 6 h and oral cyclobenzaprine 5 mg daily, which improved his pain, but the shoulder stiffness remained throughout his hospital stay and persisted for 2 months following discharge.


Initial low plasma thiamine levels confirmed the diagnosis of thiamine deficiency.


PURPOSE: To describe transient structured visual hallucinations in a patient with vascular age-related macular degeneration (AMD), following an intravitreal Avastin-injection.


At operation a black dacryolith was found, of the diameter predicted by ultrasound.


However, patients who do not respond to clozapine monotherapy can be given adjunctive treatment with ECT.


Squamous cell carcinoma with MAHA, on the other hand, has not often been reported in the English literature.


Postoperative recovery was complicated by the development on day four of bilateral herpes zoster at the T8 dermatome level.


If RD is suspected, assessment should include spirography combined with fibroscopy for examination of irregularities in the rate, rhythm, and depth of respiration.


The pharmacokinetics of oral 6-mercaptopurine (6MP) was assessed in 20 children with acute lymphoblastic leukemia during maintenance therapy.


A patient suffering from a rare enzyme deficiency developed a malignant neuroleptic syndrome after having been treated with one single dose of haloperidol.


Case report: colonic stricture and fibrosis associated with high-strength pancreatic enzymes in a child with cystic fibrosis.


We report the displacement of a tunnelled intrathecal catheter causing significant cerebrospinal fluid (CSF) leak, resulting in partial coning and a sixth nerve palsy.


A fatal case of pancytopenia due to levomepromazine.


Thereafter the maintenance dose can be small and fluctuations in the illness do not seem to occur.


Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.


A 53-year-old male, without any prior history of psychosis, developed schizophrenia 4 days after starting low-dose bromocriptine therapy for a macroprolactinoma.


Recent chickenpox contact should initiate VZV serologic studies in Reye syndrome patients, regardless of the chickenpox history or evidence of infection with other viruses.


Patients reported dramatic reduction in itching after cyproheptadine.


Ulcer became worse after tobramycin and gentamycin treatment for 2 days.


A new therapeutic regimen is suggested, which includes long-term antibiotics combined with an immediate modification of azathioprine therapy and early graft nephrectomy in selected cases with renal parenchymal involvement.


We encountered two cases of macular infarction that occurred after vitrectomy performed for mild endophthalmitis, which, on culture, yielded Staphylococcus epidermidis.


Severe hyperphosphatemia following acute tumor lysis syndrome.


Four hemodialyses with charcoal hemoperfusion were performed over 72 h.


Three cycles of chemotherapy had been administered without complications when, at the beginning of the fourth cycle, the patient developed clinical and laboratory abnormalities consistent with the development of the hemolytic-uremic syndrome.


In high-risk patients with NSTE ACS for whom an early invasive strategy is planned, enoxaparin and UFH are the agents with the highest level of evidence (evidence level A).


On followup, the patient reported disappearance of symptoms.


We report a fatal case of acute interstitial pneumonitis in a patient treated with carmustine (BCNU) for a brain tumor.


CONCLUSION: This patient's neurological deficits were not due to the epidural analgesia.


The patient responded to gluten restriction, as shown by resolution of jejunal abnormalities and skin lesions and subsequently by recurrence of jejunal abnormalities and skin lesions with reinstitution of a gluten-containing diet.


Despite the risk of needle-track seeding, PEI remains useful in the treatment of HCC.


It is unclear whether this case, similar to other cases of low-grade B-cell lymphoproliferations reported after transplantation, is related to immunosuppression and therefore part of the spectrum of PTLDs, or merely represents coincidental event occurring in an immunocompromised patient.


Amoebic disease precipitated by corticosteroids prescribed for tuberculous pleural effusions.


Although this type of hyperpigmentation has been previously seen in patients with cancer who are receiving bleomycin, this is, to our knowledge, the first reported case of bleomycin-induced hyperpigmentation in an AIDS patient and should be added to the growing list of cutaneous eruptions seen in these patients.


Both patients were heavy imbibers of alcohol and both had swallowed less paracetamol that that generally regarded as a lethal dose.


Histology of a cutaneous lesion showed spongiosis and infiltration of the epidermis by atypical lymphocytes with large hyperchromatic nuclei, perivascular dermal lymphocytic infiltrate (CD3+) mixed with plasma cells and occasional large immunoblasts (CD20+).


All the alternative medications for rheumatological patients are significantly more toxic than HCQ.


Chickenpox in adult renal transplant recipients.


Microscopic examination showed nests of mature adipocytes expanding toward the dermal reticular layer.


One of the 3 patients was reexposed to etanercept later on.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


Prior sexual profile included from no sexual outlet to hypersexuality.


CE was confirmed either by renal biopsy (case 1) or skin biopsy (case 2).


CASE SUMMARY: A 25-year-old postpartum white woman developed multiple watery stools and abdominal cramping on day 6 of therapy with clindamycin vaginal cream for bacterial vaginosis.


DISCUSSION: On four separate occasions the patient was challenged advertently or inadvertently, with sustained-release verapamil.


Herpes simplex keratitis in renal transplant recipients.


Choanal atresia and athelia: methimazole teratogenicity or a new syndrome?


Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports).


His renal function returned to baseline 14 days later with supportive care, folinic acid rescue, and urinary alkalinization.


Another four patients went into partial remission, amounting to an overall response rate of 58%.


We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21.


Preliminary evidence for inhibitory effect of glycyrrhizin on HIV replication in patients with AIDS.


Prothrombin complex concentrates (PCCs) and, more recently, activated prothrombin complex concentrates (APCCs), are widely used for the treatment of active bleeding in haemophiliacs with inhibitors.


A new type of minocycline-induced cutaneous hyperpigmentation.


It has been associated with phenytoin, cyclosporine, and calcium channel blocking agents.


An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.


CONCLUSIONS: Colchicine-induced myopathy should be excluded in patients with FMF who present with generalized muscle weakness.


The patient was treated surgically by foramen magnum decompression and occipito-cervical fusion, and by transoral resection of the clivus.


He had also developed elevated serum ammonia levels while on valproic acid.


Moreover, as the pathophysiology of this disorder becomes less of a hypothesis and more of an understood entity, it is likely that treatment options will broaden beyond the use of daily prophylactic colchicine.


The course of this case may be useful in the understanding of the pathogenesis of autoimmune hyperthyroidism.


More recent case reports have concentrated on the use of cardiopulmonary bypass.


Twelve patients reported improvement in pain and mood, while 11 reported improvement in sleep.


We report a case of tularemia presenting as a solitary pulmonary nodule following syngeneic PBSC transplant.


Various combinations of antibiotics have been successful in achieving cure; however, at present, high-dose penicillin (greater than 25 million units/day) in combination with an aminoglycoside for a period of six weeks appears to be the optimum therapy.


Neurological evaluation of children with ALL at diagnosis and during treatment is of value in order to diagnose neurological complications early so that appropriate intervention can be adopted.


However, a surgical approach consisting of resection of the colon may sometimes be necessary, even in patients with complete aplasia and a high risk of complications.


Dosing adjustment in patients with renal dysfunction is not necessary for anastrozole.


All the data suggested that the antibiotic was responsible for the deterioration in renal function.


These included advanced age, chronic lung disease, liver disease, and administration of cimetidine.


This case report describes the unanticipated development of pyometra in Brown Norway rats after treatment with estrogen.


RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings.


A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.


Aminoglutethimide was discontinued until completion of radiotherapy, and the rash resolved.


Magnetic resonance imaging was more useful than computed tomography in the early diagnosis and management of these acute lymphocytic leukemia patients with leukoencephalopathy.


Computed tomography of the brain was normal but electroencephalography showed focal theta and delta slow waves over the right temporal-parietal-occipital area.


To our knowledge, this case is the first published report of levofloxacin-induced TEN.


This is the second report to describe such findings, which are attributed to damage of the inferior division of the third cranial nerve secondary to manipulation of adjacent ethmoid tissues.


After 15 minutes, amiodarone infusion (25 microg/kg/min) eliminated further paroxysms in both patients, allowing both interventions to be completed safely and effectively.


Serum potassium values higher than 7 mmol x l-1 are associated with cardiac arrhythmias and an increased incidence of intraventricular haemorrhage and periventricular leucomalacia.


We describe longitudinal diffusion-weighted MRI findings of sub-acute leukoencephalopathy following methotrexate therapy in a 24-year-old man diagnosed with pre-B-cell acute lymphoblastic leukemia (ALL), presenting with right-sided paralysis and aphasia after second consolidation with intrathecal triple-drug therapy given intrathecally.


Adhesions to manufacturer's trademark on the surface of a posterior chamber lens.


Acute coronary vasospasm during thoracic spine surgery.


This article describes a safe and highly effective augmentation technique in patients suffering from some of the most serious and debilitating forms of anxiety disorders, namely obsessive-compulsive disorder and panic disorder.


The possible causes included underlying artherosclerosis, the use of pneumatic tourniquet, surgical manipulation, and arterial spasm.


Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.


She had taken feedings through a nasogastric tube with 1000 ml (1000 kcal) of Ensureliquid daily since 1993 because of the muscle weakness after rhabdomyolysis.


Interventional pain management is an evolving field and the standard of care is broadly defined.


Therefore, contact lens wear should be discontinued to prevent further complications.


Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA).


Endoscopic retrograde cholangiopancreatography demonstrated normal biliary tree and pancreatic ducts.


Bleomycin induced hyperpigmentation with yolk sac tumor.


These malignancies may represent either a new clonal disorder or a complication of drug treatment.


Choline magnesium trisalicylate was then administered in an effort to control her fever, and was successful.


This issue is important, given the increasing use of chemotherapy in combination with radiotherapy.


Adverse reaction to prednisone in a patient with systemic lupus erythematosus.


Plasma exchange with either fresh-frozen plasma or 5% albumin solution as replacement fluid was performed in four selected patients with juvenile rheumatoid arthritis unresponsive to standard therapy.


Angio-oedema as an unusual tolerable side effect of voriconazole therapy.


A case report.


The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.


Association of fluoxetine and return of sexual potency in three elderly men.


Myocardial ischemia associated with high-dose carmustine infusion.


RESULTS: Best corrected visual acuity before injection was 6/60 in the left eye.


New observations, including CT scan findings and experience with treatment by praziquantel.


Further doses were required as the respiratory depression recurred.


CONCLUSIONS: We report the association of postoperative chylothorax treated with somatostatin analog (octreotide) and necrotizing enterocolitis in an infant following aortic coarctation repair.


The brain and spinal cord were examined routinely, and histological sections were taken for evaluation.


CONCLUSIONS: Anti-TNFalpha antibodies appeared in this case to improve TPN-related cholestasis.


Charcoal haemoperfusion and cysteamine therapy led to the rapid removal of the paracetamol from the body and consequently prevented the development of severe hepatic necrosis.


It should be emphasized that the recurrence of nephrotic syndrome was observed after the following chemotherapy, including M-CSF, whereas the bone marrow still remained completely remitted.


The use of monoamine oxidase inhibitors in the treatment of elderly, depressed patients.


Fatal hepatic failure caused by chemotherapy-induced reactivation of hepatitis B virus in a patient with hematologic malignancy.


ECG showed marked ST elevations consistent with acute myocardial infarction.


Subsequent liver biopsy showed low-grade lobular hepatitis.


They both required treatment with insulin, one in very high dosage, but their insulin requirements fell progressively after the atypical antipsychotic was withdrawn.


Other possible differential diagnoses were magnesium overdose or a post-ictal state.


The drug combination resulted in persistently elevated urinary Histoplasma antigen levels and subtherapeutic plasma itraconazole concentrations.


Laparotomy revealed it to be unresectable.


Emergency coronary angiography revealed no major coronary atherosclerosis.


Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.


Children with acute lymphoblastic leukemia (ALL), treated with L-asparaginase are at risk for cerebral thrombosis or hemorrhage because of coagulation protein deficiencies.


Although pathologic confirmation of the cause was not possible, the potential for this alarming complication should be recognized by physicians prescribing epidural steroid therapy.


We suggest that itraconazole should be added to the list of drugs that may be responsible for a drug-induced vanishing bile duct syndrome.


CONCLUSION: Treatment of hypotension with beta-agonists in VLBW infants with left ventricular hypertrophy can lead to hypercontractility and left ventricular obliteration with paradoxical hypotension.


In one patient, it was demonstrated that the discontinuation of enalapril was followed by a decrease in renal blood flow and a significant increase in the plasma erythropoietin levels that preceded the rise in hemoglobin.


One should use caution in the interpretation of magnetic resonance imaging scans of the shoulder soon after the injection of corticosteroids.


Two cases of vesicouterine fistula, caused by lower-segment cesarean section, are presented.


BACKGROUND: Tamoxifen, a widely used drug in adjuvant therapy of breast carcinoma, is now being tested for its effectiveness in chemoprevention.


Thus, t(4;11)(p12;q23) with MLL and FRYL involvement represents a new recurring 11q23 translocation, to date seen only in therapy-related acute leukemias.


While the patient had evidence of underlying kidney disease, the timing of his renal failure indicates that TDF played a central role.


Although the intended length of treatment was a minimum of 8 weeks, only three patients completed 8 weeks of therapy, one patient completed 6 weeks, two patients completed 4 weeks and one patient was discontinued after 5 days.


We report a case of primary non-Hodgkin gastric stump lymphoma, found in a 78-year-old man 30 years after a distal gastrectomy for a benign peptic ulcer.


He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.


Only nondepolarizing muscle relaxants should be used in patients who are at risk for mucositis.


Ultimately, the choice of treatment will depend upon the patient's risk of recurrence and progression.


Mercury sensitisation: review, relevance and a clinical report.


She gradually recovered from these symptoms during subsequent 7 days.


Patients from endemic areas referred to transplant centers may be at high risk for disseminated histoplasmosis when treated with long-term prednisone for graft-versus-host disease.


Seizures were treated with diazepam.


Histologically, the fungal organisms demonstrated markedly enlarged blastoconidia with a variety of morphologic forms, mimicking other mycotic organisms, such as Cryptococcus neoformans, Blastomyces dermatitidis, and Paracoccidioides brasiliensis.


Loss of speech after orthotopic liver transplantation.


Taken together with other evidence that fluoroquinolones lower seizure threshold, this report suggests fluoroquinolones should be avoided in patients receiving ECT.


Sodium bicarbonate should be given early in the resuscitation, and re-administered as frequently as required, targeting an alkaline pH and improved cardiac output, while accepting hypernatraemia.


Intrahepatic cholestasis and sicca complex after thiabendazole.


A multicentric retrospective pilot study was undertaken to detect GCV-resistance through mutations within the UL97 gene in renal transplant recipients who experienced active HCMV infection and received valacyclovir prophylaxis.


Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.


Subsequent reversal was by intravenous administration of calcium chloride.


One case of tacrolimus-induced hepatic VOD developing after lung transplantation (LT) has been recently reported.


In this study a case of BP which was difficult to control with systemic steroids was successfully treated with mycophenolate mofetil as adjuvant therapy.


New criteria for the diagnosis of infective endocarditis.


We report a case of intracardiac thrombus in a patient supported by the Jarvik 2000 Flowmaker successfully treated with a single dose of peripherally administered TNK-tissue plasminogen activator (Tenecteplase, Metalyse, Boehringer Ingelheim).


The dog remains healthy despite the marked increase in the number of circulating platelets.


There is direct and indirect evidence for various immunologic and nonimmunologic pathways precipitating the reaction.


Our experience supports its efficacy in this setting, and to the best of our knowledge this is the first report of successful treatment of cutaneous warts with IV Cidofovir in a pediatric case.


In vivo confocal microscopic findings of interlamellar stromal keratopathy induced by elevated intraocular pressure.


We describe rupture of a cerebral arterial aneurysm in a 32 year old hypertensive woman following the introduction of nifedipine treatment.


Serum tryptase levels drawn during the infusions were low, signifying controlled mast cell degranulation.


A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.


A hemagglutinin mutation (198 Thr-->Ile) reduced the virus affinity for receptors found on susceptible human cells.


A 76-year-old woman was admitted to our department for evaluation of left facial pain, confusion and disorientation.


Mucormycosis peritonitis: more than 2 years of disease-free follow-up after posaconazole salvage therapy after failure of liposomal amphotericin B.


9. More accurate assessment of risk: benefit ratios awaits the results of prospective controlled studies.


The Ensure Plus was continued and adequate prothrombin times were achieved on 7.5 to 10 mg of warfarin daily.


Infections secondary to Leuconostoc are uncommon, and usually affect patients with underlying diseases, prior use of vancomycin and those with central lines.


Occurrence in mycosis fungoides treated with psoralens plus long-wave ultraviolet radiation.


After the initial resuscitation and the subsequent treatment of shock and vitamin K deficiency, acute peritoneal dialysis was instituted to correct the severe lactic acidosis.


Currently available research on the use of risperidone to manage agitation in patients with dementia is discussed.


Hypercalcemia has not been previously reported during treatment with topical tacalcitol.


A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.


While the association of psoriasis and lupus may have been fortuitous, the temporal relationships suggest that PUVA treatment in this case may have been of pathogenetic importance in the development of the connective tissue disease.


A periodic examination of the nasal septum should be undertaken in patients with ABPA and rhinitis on long term inhaled oral and intranasal corticosteroids along with oral corticosteroids.


Quetiapine in relapse prevention in alcoholics suffering from craving and affective symptoms: a case series.


Laboratory investigation disclosed a high anti-Toxoplasma IgG titer.


The excessive accumulation of copper in many tissues illustrates the potential danger of parenteral copper therapy.


Moreover, the disease invariably recurs in the graft kidney and causes graft failure.


Apomorphine-induced erections in PD are probably more common than previously thought.


Severe aphthous stomatitis associated with oral calcineurin and mTOR inhibitors.


Alternative medicine is becoming increasingly popular, especially with terminally ill patients.


Oral ketamine: a promising treatment for restless legs syndrome.


The results were judged to be good in 36.6% of the cases, moderate in 36.6% and poor in 26.7% of the cases.


All developed mucocutaneous side effects within 20 weeks of beginning im gold therapy, at a time when RA had improved markedly compared to pretreatment status.


Treatment of hepatocellular carcinoma using arterial chemoembolization with degradable starch microspheres and continuous arterial infusion of 5-fluorouracil.


Optical coherent tomography and fluorescein angiography showed an almost complete resolution of cystoid macular edema.


No recurrence was seen in the 12 to 19 month follow-up.


We report the case of an adult patient with acute lymphoblastic leukemia who presented with repeated transient ischemic attacks followed by a seizure during consolidation treatment with L-asparaginase.


Transient leucopenia and thrombocytopenia associated with sodium nitroprusside infusion.


Protein C, protein S, and antithrombin III were normal, and factor V Leiden and prothrombin gene mutations were absent.


The diabetes improved when the treatment was discontinued and worsened on re-introduction.


The IgA was normalized after phenytoin withdrawal, but IgE determination increased progressively without any atopic symptoms.


Intravenous cimetidine administered q8h offers a safe and cost-effective approach to H2-receptor blockade and reduction of gastric acid secretion in patients who are temporarily unable to take oral medication.


Thrombocytopenia has traditionally been associated with intermittent therapy.


Renal failure is a rare complication associated with the use of rifampicin for the treatment of tuberculosis, usually occurring well into the course of therapy.


The ophthalmological examination was normal, except for extensive bilateral maculopathy with shining crystalline deposits, central and peripheral visual field defects, slightly affected scotopic and photopic potentials in the flash-ERG, and an abnormal m-ERG.


Antibiotic therapy consisting of Amoxicillin and Gentamycin was given for seven days.


Steroid therapy predisposes to early dissemination and a potentially fatal outcome.


One of the patients had had earlier exposure to typical antipsychotic drugs, but no other predisposing factors for TD were noted.


Common adverse events (frequency 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence).


The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed.


Ten to 15% of patients treated with ifosfamide develop an encephalopathy.


DISCUSSION: Serotonin syndrome is a potentially lethal pharmacodynamic interaction between medications that increase serotonergic transmission at the synaptic junction.


Management of suspected neuroleptic malignant syndrome.


CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.


The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.


CLINICAL RELEVANCE: Gabapentin appeared to be a safe, effective, and economical treatment for neuropathic pain in this horse.


CONCLUSIONS: Metoclopramide may cause reversible nonthrombocytopenic vascular-type palpable purpura.


Moreover, the IgG subclasses in glomerular deposits and the presence of chimeric renal cells were studied.


RESULTS: Treatment with this topical fluorinated corticosteroid produced a measurable reduction in the size of the hemangiomas, which permitted clearing of the visual axis.


DATA SOURCES: Case studies, abstracts, and research publications identified in MEDLINE and bibliographic review.


Retinal pigment epithelial tear following photodynamic therapy for choroidal neovascularization secondary to AMD.


The pacing system consists of an implanted receiver-lead system and an external patient-activated transmitter.


Genitourinary malacoplakia in renal transplant recipients: pathogenic, prognostic and therapeutic considerations.


Two patients with imminent gangrene of the extremities caused by ergot-induced arteriospasm underwent mechanical dilatation of the arteries when conventional measures such as anticoagulation, vasodilation, and sympathetic blockade produced no improvement.


Three days later, he presented with evidence of massive deep haemorrhage to the point of airway compromise.


Since herpesvirus has been shown to survive in the hot tub environment, herpes simplex should be considered as another potential cause of disease in the spa setting.


We report the case of a 43-year-old man with ITP refractory to steroids and intravenous immunoglobulin who developed acute respiratory distress syndrome (ARDS) after a single infusion of rituximab.


After a subacromial injection with betamethasone and lidocaine, the patient noted 3 weeks of near complete pain relief, followed by a return of her symptoms.


The purpose is to report a complication after photodynamic therapy (PDT) and intravitreal triamcinolone for a presumed choroidal neovascularization in age-related macular degeneration.


Descemet folds and an atypically large amount of stromal edema were present in both cases, and there appeared to be possible endothelial dysfunction as well.


She had been on Copaxone 20 mg/day treatment for 2 years when she first exhibited gastrointestinal symptoms.


We believe that ritonavir-mediated induction of VPA glucuronidation resulted in a decrease in VPA concentrations and efficacy.


Intravesical formalin instillation has been performed in a patient with massive bladder hemorrhage secondary to radiation cystitis.


Psychosis associated with oral contraceptive-induced chorea.


In 25 patients in whom ectopy persisted despite drug therapy, there were 17 sudden deaths.


Naratriptan in the prophylaxis of transformed migraine.


Specific inhibitors of 5-HT reuptake are reported to have lower proconvulsive activity than other antidepressants.


Annual tests of serum ferritin showed progressive increase.


Since imiquimod induces large amounts of type I interferon production from TLR7-expressing plasmacytoid dendritic cell precursors (PDCs), the natural interferon-producing cells of the peripheral blood, we asked whether PDCs are present in psoriatic skin.


Case study on drug-related adverse effects of hepatitis C therapy.


CONCLUSIONS: VVR stimulates mucin secretion and MCTV in the LPS-inflamed ferret airway.


OBJECTIVE: To report a case of Cushing's syndrome in an adult patient caused by prolonged and unsupervised use of glucocorticoid ocular drops.


Occurrence of IDDM during interferon therapy for chronic viral hepatitis.


Thrombocytosis under ciprofloxacin and tazobactam/piperacillin.


The autofluorescence technique was used to predict the risk of CNV in the fellow eye.


Acne fulminans and 13-cis-retinoic acid.


BACKGROUND: Severe vulvar edema is an extremely rare complication of pregnancy.


We describe a renal transplant recipient infected with Pneumocystis carinii pneumonia (PCP) who developed hypercalcemia, elevated 1,25-dihydroxyvitamin D, and suppressed parathyroid hormone levels.


Thus catheter-related cutaneous aspergillosis could lead to a severe deep-seated infection in HIV-positive patients.


The authors report on two patients with corneal ulcers refractory to conventional treatment while the patients were undergoing oral colchicine therapy.


We report the successful treatment of heparin-induced thrombocytopenia and subsequent hemorrhagic complications postoperatively in a 2-year-old child with Danaparoid (orgaran).


The authors suggest that in the absence of any proven benefit of itraconazole prophylaxis, and given the interaction of this drug with vincristine leading to severe and even potentially fatal toxicities, the combination use of these drugs should be avoided.


Prosthetic valve endocarditis (PVE) due to Legionella micdadei was diagnosed in a man a year after valve replacement with a bovine xenograft.


If the infection takes a persistent course, persistent topical and intravitreal antibiotic treatment and possibly vitrectomy are needed to eradicate the infection.


RESULTS: Prolonged suppression of circulating serum cortisol concentrations and cortisol responses to the Synacthen stimulation test were noted in 3 cases, and marked failure to thrive was noted in all 4 cases.


Histoplasma capsulatum (HC) is a thermally dimorphic ascomycete that is a significant cause of respiratory infections (>80%) in endemic areas (Midwest and southeast USA), but infections are rare in non-endemic areas.


In this report two patients presenting with rippling muscles followed by myasthenia gravis are described.


Histology showed pigment within dendritic cells, and extracellularly throughout the dermis.


Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.


INTERVENTIONS: None.


The phenytoin only modified the IgA levels.


Results of laboratory studies were normal and the patient was treated with topical therapy.


A 1-month-old infant suffered cardiac arrest shortly after presentation to the emergency department.


We describe a 25-year-old, human immunodeficiency virus (HIV)--negative man, who was started on antituberculosis treatment (ATT) with isoniazid (H), rifampicin (R), pyrazinamide (Z) and ethambutol (E) in the combination RHZE for the first two months and RH there on.


BACKGROUND: We describe the ophthalmic features and clinical course of two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) that developed after intravitreal triamcinolone acetonide (IVTA) injection.


He had previously failed induction therapy with cyclophosphamide, vincristine, adriamycin, and dexamethasone, but achieved complete remission after melphalan therapy.


The WBC count should be determined and the patient's circulatory status evaluated to rule out hypovolemia.


Porphyria cutanea tarda, a metabolic disorder of heme biosynthesis, is characterized by cutaneous hyperpigmentation, facial hypertrichosis, dark urine, and a distinctive pattern of excess porphyrin production.


Ferrous sulfate-induced increase in requirement for thyroxine in a patient with primary hypothyroidism.


Treatment of leukemia relapse after bone marrow transplantation with interferon-alpha and interleukin 2.


The patient reported immediate and sustained improvement in his post herpetic neuralgia for over two months, without adverse effects from the calcitonin therapy.


RESULTS: Two patients with ocular inflammation of unknown origin developed severe chorioretinitis after IVTA injection.


Other potential mechanisms for the drug interaction may also exist.


Eighty-two patients with various malignancies who received imipenem/cilastatin 143 times for neutropenic fever between March 1994 and October 1999 in Department of Pediatric Oncology, Gazi University, were identified.


Chest X-ray revealed a solitary pulmonary nodule.


This circular area corresponded to the 3500 microm diameter of the laser spot used in the PDT treatment.


Successful treatment of cryptococcal ventriculoatrial shunt infection with systemic therapy alone.


Organ transplant recipients on immunosuppressant therapy are at risk of developing lymphoproliferative disorders.


The ATL proved refractory to chemotherapy, and he underwent BMT conditioned with CY/TBI.


It can occur in association with altered immunological conditions and the administration of various drugs, including corticosteroids.


However in some patients requiring emergency cardiac or vascular surgery, reexposure to heparin may be unavoidable.


This may be due to a change in the type of metabolites excreted.


The response to chemotherapy was not satisfactory.


Major abnormalities were confined to the heart and brain.


We present a case of a diabetic patient taking glyburide who was prescribed ciprofloxacin and developed prolonged hypoglycemia, which persisted for over 24 hours.


After three weeks of carbamazepine therapy, the patient arrived at the emergency department (ED) with severe agitation and aggressive behavior.


A 43-year-old white man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate.


CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.


A rebound in levels of intercellular antibodies usually followed their depletion but could be minimized or completely suppressed by administration of cyclophosphamide.


CONCLUSION: For severe cases of TiACG that are associated with very high intraocular pressures, the combination of mannitol and methylprednisolone can induce a rapid improvement.


Heparin-associated thrombocytopenia and thrombosis is a severe complication of systemic heparin therapy.


Pericardial hemorrhage due to acetylsalicylic acid in a patient with essential thrombocythemia.


Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates.


Steroid-induced acute psychosis in a child with asthma: report of one case.


The pathogenesis and management of this process are reviewed.


There have been many reports of probable lithium-induced organic brain syndromes occurring when serum lithium levels are within or close to the therapeutic range.


Interestingly, continuation of the interferon therapy in the presence of a mild-to-moderate exacerbation of sarcoidosis may be safe in a minority of patients with noncritical organ involvement.


The addition of ADV was efficient to treat LAM-resistant HBV.


At autopsy, microscopy showed that most of the thyroid follicles were enlarged with dense colloid substance and lined by flattened follicular cells (involuted follicles).


Jaundice induced by streptokinase.


The postoperative course was complicated by slight override of the graft associated with an associated epithelial defect, but there was no evidence of microbial keratitis or significant anterior chamber inflammation.


Diffusion-weighted MRI (DWI) may help to distinguish between ischemic stroke and chemotherapy-related leukoencephalopathy.


She had previously been treated unsuccessfully with a number of atypical antipsychotic medications, before she was eventually started on clozapine.


We present a case of interaction between ritonavir and carbamazepine.


Neurological examination revealed bilateral ptosis, and complete external opthalmoplegia with normal pupillary and corneal reflexes.


The pathogenesis of the porphyria is not clear; however, cyclophosphamide is a substrate for cytochrome P450, and may produce metabolites that destroy this protein.


As a result, we identified total 11 patients with nocturia and three of those completed the 12-week study of switching dopamine agonist from bromocriptine to pergolide.


Visual fields and tiagabine: a quandary.


Unexpected severe reversible cyclosporine A-induced nephrotoxicity in a patient with systemic lupus erythematosus and tubulointerstitial renal disease.