Painful erosion of psoriatic plaques is a less common sign of methotrexate toxicity that may precede evidence of bone marrow suppression.


This case may be an example of cryptogenic form of reflex epilepsy with seizures induced exclusively by tooth brushing.


However, serum HBV DNA turned detectable again after 9 months of LAM therapy and a YMDD mutation was detected.


His wound cultures continued to be negative.


Successful use of oral ganciclovir for the treatment of intrauterine cytomegalovirus infection in a renal allograft recipient.


As far as we know, this is the first report in English literature indicating such an adverse effect of pegylated interferon alpha.


After 582 allogeneic bone marrow transplants, we have encountered four patients (0.7%) who developed transient unilateral or bilateral sixth nerve palsies.


Photopatch tests to 1% mequitazine with 5 J/cm2 of UVA in 30 normal subjects were all negative, which means that 1% concentration may be appropriate for the photopatch test.


Seven patients, five male and two female (mean age 75.3+/-4.7 years, range 68-81), diagnosed with DLB were treated with the acetylcholinesterase inhibitor donepezil (5-10 mg once daily) to determine its effect on treating behavioural disorders.


OBJECTIVE: Traditional monoamine oxidase inhibitors (MAOIs) continue to play an important role in the management of a wide variety of clinical conditions.


A patient receiving allogeneic bone marrow transplant for treatment of acute myelomonocytic leukemia died on the 78th post-transplant day with clinically unrecognized disseminated histoplasmosis.


Four previously reported cases with the same sequence of events are reviewed as well as cases of chronic myelogenous leukemia following chemotherapy alone.


Air conditioning and proper ventilation of the operating room, the use of coolant sprays, good suction and proper handling of amalgam waste is recommended.


When high dose leucovorin was not used, residual neurological damage is not unusual.


In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.


It was confirmed histologically.


MR of the brain was performed in eight patients (mean age, 14.9 years) with osteogenic sarcoma during or after IV treatment with high-dose methotrexate.


Malignant neoplasm after immunosuppressive therapy is a well-known entity.


A rechallenge, performed in both patients, confirmed the diagnosis of mesalamine-induced pancreatitis.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


CONCLUSION: Healthcare professionals should be aware of the possible development of serotonin syndrome as a complication of initiation of fentanyl and other phenylpiperidine opioids in patients treated with SSRIs.


This case documents the first report in the otolaryngology literature describing this new etiology for nasal septal perforations.


Three were not assessable.


Porcine factor VIII (pFVIII), which is used to control bleeding in patients with congenital or acquired haemophilia who have high-titre neutralizing antibodies to human FVIII, is not known to increase the risk of arterial or venous thrombosis.


Two months later, hyponatremia was diagnosed, most likely syndrome of inappropriate antidiuretic hormone secretion.


As the disfiguring lesions had a marked adverse effect on her quality of life, a trial of IV Cidofovir was instituted.


Desquamative interstitial pneumonitis complicating inflammatory bowel disease of childhood.


Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity.


This is the first reported case of hepatolithiasis during octreotide therapy.


Report of a case and review of the literature.


We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury.


In renal transplant patients living in endemic countries, visceral leishmaniasis should be kept in mind as a potential cause of unexplained long-standing fever and considered as an opportunistic infection.


These findings are consistent with an immune-complex form of glomerulopathy in which gold is neither the antigen nor a hapten in the glomerular deposits, and they suggest the hypothesis that antibodies to tubular epithelial antigens induced by gold therapy may be a causative factor in the renal disease associated with gold therapy in rheumatoid arthritis.


His clinical course and laboratory studies are discussed.


At this time most of the DGTX in serum was FAB-bound.


Mammographically the malignant microcalcifications appeared only in the region of the breast where the primary tumor was found.


One patient also manifested marked disinhibited and disruptive sexual behavior.


Two of the three cases had received blood transfusions, and attention is drawn to the possibility that mitomycin C may sensitise the kidneys to minor mismatches.


Combined intoxication with a tricyclic antidepressive agent and a neuroleptic.


Treatment was modified, symptoms resolved in 1 to 2 weeks, and the white-matter changes resolved over 6 to 12 months.


Based on newly published data we have applied an infusion of both compounds, 5-FU and calcium folinate, mixed together in an ambulatory pump.


The patient's platelet count dropped rapidly to a level of 1000/mm3 after receiving a single 600 mg dose of rifampin.


Catecholamine treatment for hypotension is common practice in neonatal intensive care units.


Contact dermatitis treated with new topical products: a case study.


Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.


Infant twins sustained severe circumoral and pharyngeal burns from a concentrated solution of benzalkonium (Zephiran) chloride prescribed for treatment of candidiasis.


He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.


The benefit of apomorphine on sexual function in some patients suggests a possible role in the treatment of impotence in PD.


Cultures of the cornea tissue and contact lens storage solution both grew Serratia Marcescens, which was sensitive to ciprofloxacin.


This case report raises one more time the question about the safety of the LORA technique for labor analgesia.


BACKGROUND: Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare.


Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders.


Adenomyosis confined to the broad ligament is extremely rare.


Based on these survival data the administration of concomitant cisplatin and radiotherapy has become standard of care for nasopharyngeal carcinoma in the USA.


BACKGROUND: To assess the nature, incidence, and risk factors of retinopathy associated with pegylated interferon and ribavirin combination therapy in chronic hepatitis C patients.


Metabolic imbalance appears as the leading aetiology, among several other hypotheses.


The relationship between chronic inflammatory conditions and malignancy is complex.


A new alkaline propanolamine derivative, enciprazine, was tested in an early phase-II semi double-blind placebo-controlled A-B-A design to verify the hypothesis that the substance may have tranquilizing properties.


A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer.


CASE SUMMARY: A 35-year-old African American woman with a history of primary pulmonary hypertension managed with warfarin, diltiazem, and hydrochlorothiazide was initiated on bosentan therapy.


After intravenous antibiotic treatment, the infection resolved with full restoration of visual acuity and ocular motility.


Neuroleptic-induced panic attacks in a patient with delusional depression.


Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.


The area healed slowly over 7 weeks, but there was a residual loss of cutaneous sensation.


The use of an indium111 DTPA flow study in the evaluation of a lumbar swelling in a girl with a baclofen pump.


One of the cases involved a 72-year-old woman who died with Salmonella enteritis and sepsis that had not responded to treatment with chloramphenicol.


We report a case of coagulation activation, fluid retention and transient autoimmune hepatitis most likely triggered by the use of black cohosh.


A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.


Respiratory distress, severe VOD and grade II acute gastrointestinal GVHD complicated the post-transplant period.


METHODS: A case report of a patient with ovarian cancer extensively treated with platinum-based chemotherapy and aggressive surgery is presented.


Unlike other macrolide antibiotics, it is not hepatically metabolized and did not produce an interaction with warfarin in a single-dose study.


Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.


Histiocytic lymphoma of the ileocecal region after chemotherapy for multiple myeloma.


We report on a patient with acromegaly who developed severe drug-induced hepatitis during combined treatment with the long-acting somatostatin-analog octreotide and the GH receptor antagonist pegvisomant.


CASE REPORT: This 36-year-old woman had rheumatoid arthritis that proved refractory to sulfasalazine and methotrexate, which were used successively in combination with symptomatic drugs.


Primary central nervous system lymphoma in a patient treated with natalizumab.


A patient with a second-degree burn of the forehead, induced by topical application of crushed garlic is reported.


The HIV protease inhibitor indinavir may cause nephrolithiasis and interstitial nephritis.


This side effect has never been reported for this nitrosourea but only for BCNU and methyl-CCNU.


TD was relatively mild, with a mean score of 4.75, and tended to accentuate with an activation procedure of rapid pronation and supination of the hands.


The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma.


Systemic allergic contact dermatitis to 8-methoxypsoralen (8-MOP).


Current therapy with oral baclofen and benzodiazepines is useful but has variable success, particularly in severe cases.


In case of relapse the clinically important question of discontinuation of lithium versus the concurrent use of ECT and lithium may arise.


We wish to alert other anaesthetists that the use of epidural anaesthesia in this setting may mask the symptoms and delay the diagnosis of this rare complication.


We report four cases of encephalopathy coincident with elevated aluminum levels as well as one patient who developed seizures while receiving continuous bladder irrigations with alum.


We describe a case of extensive thromboembolism associated with antithrombin (AT) deficiency complicated by thrombocytopenia which resolved when low-molecular-weight heparin was instituted.


Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.


Diffuse proliferative glomerulonephritis after bone marrow transplantation.


Although both the spontaneous occurrence of SLE and the psychosis as a sign of CNS involvement of SLE cannot be excluded, SLE could be considered as an adverse effect of carbamazepine.


We described the occurrence of L-dopa-induced myoclonus and seizures in a case of parkinsonism with its SEPs findings.


Glycopeptide-induced neutropenia: cross-reactivity between vancomycin and teicoplanin.


Bronchiolitis obliterans organizing pneumonia simulating progression in bronchioloalveolar carcinoma.


A 68-year-old male was admitted for interstitial pneumonia associated with scleroderma.


Treatment of neutropenia in a renal transplant recipient with granulocyte colony-stimulating factor.


Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus.


OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.


Several years after the original diagnosis, he was found to be ACTH deficient and following commencement of hydrocortisone replacement therapy became hypernatraemic.


Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.


Within hours of leaving the operating room, he began to develop postoperative neurologic deficits in his extremities, which progressed to a classic Brown-Sequard syndrome.


Cluster-like headache after surgical crystalline removal and intraocular lens implant: a case report.


Drug-induced rhabdomyolysis is an established but rare adverse effect of high doses of cholesterol-lowering agents (statins) or interactions between drugs (eg, statins and fibrates).


Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.


Hereditary motor and sensory neuropathy type 1 (HMSN-1) is an autosomal dominant disorder, which is usually not associated with neoplastic diseases.


The patient described feeling cold with worsening headache and chills approximately one hour after infusion of the first dose of penicillin.


We also interviewed a series of 14 women in California who had recent Accutane-exposed pregnancies to identify opportunities for prevention.


Physicians who use sulfasalazine to treat patients with inflammatory bowel disease should be aware of the signs of sulfasalazine-induced lupus syndrome.


A case is presented where combined intravitreal triamcinolone and photodynamic therapy stopped the progression of the exudative macular degeneration.


The both agents were given for 3 weeks and were well tolerated without any side effects.


The only adverse effect was atrioventricular block in two children, which was completely reversible.


After 3 weeks of CI a thrombus formation in the portal vein was detected by ultrasound and confirmed by duplex ultrasound.


Tolerance to dobutamine was obviated by giving infusions twice weekly.


These perfusions gave a moderate or good temporary palliation as regards to tumor growths on the extremity.


Aircrews are tested every 3 mo for HbA1c levels.


DESIGN AND METHODS: A specimen of resected TSHoma tissue from our case was immunohistochemically examined for expression of somatostatin receptor 2A (SSTR2A) and PPAR gamma.


We experienced 2 cases of mequitazine-induced photosensitivity reaction in patients who took mequitazine for their dermatologic problems.


He presented symptoms of fever, skin lesions consisting of multiple vesiculopapular rashes, pruritic maculae and bullae, and mucosal involvement of the eyes, lips, oral cavity, and anorectal junction.


The mother had used lamotrigine in increasing doses throughout pregnancy, and at the time of the apneic episodes, she used 850 mg/day.


CONCLUSIONS: Clinicians treating elderly patients with olanzapine should be aware of the potential for rapidly developing hyperglycemia and monitor such patients accordingly.


Cutaneous seeding after ultrasound-guided percutaneous ethanol injection for treatment of hepatocellular carcinoma.


We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously.


The drug was prescribed for transient ischemic cerebrovascular accidents.


We report a patient with a malignancy and upper gastrointestinal bleeding who underwent a gastric lavage followed by an endoscopy as part of her investigations.


Nineteen cases of unusual enhanced vincristine neurotoxicity related to itraconazole have been reported in children.


The chemotherapy regimen consisted of cis-platinum, etoposide, actinomycin-D, and intrathecal methotrexate (PEA-M).


We propose a prophylactic and curative approach to decrease morbidity related to CMV infection in active UC.


In addition, not enough controlled clinical trials have yet been conducted.


The use of therapeutic drugs forms one of the important causes of hiccups.


Paranoid psychosis may result from intoxication with, or withdrawal from amphetamines.


8 months later she was scheduled for salvage chemotherapy with gemcitabine (1,000 mg/m(2) days 1 and 8) and docetaxel (75 mg/m(2) day 8) due to locally progressive disease.


RESULTS: The suggested algorithm includes: 1) Supportive care and withdrawal of all potentially offending agents; 2) Laboratory evaluation with prompt initiation of treatment for both disorders--cyproheptadine for SS and dantrolene for NMS; 3) Do not use bromocriptine (contraindicated in SS) or chlorpromazine (contraindicated in NMS) initially; 4) Add bromocriptine when clinical presentation becomes consistent with NMS (SS can be prolonged if serotonergic agent has long half-life).


We suggest that familiar TGA could be caused by the mechanism of vasospasm rather than venous congestion and that the abnormal cerebral vasomotor control could be the hereditary substrate in this condition.


Steroid diabetes experienced by the reported cases may be a marker for the onset of diabetes in their adulthood.


The process worsened during the two weeks following steroid cessation.


Speech arrest, agitation, tremor, ataxia, and downward gaze deviation in a 5-year-old female 13 days after orthotopic liver transplant are reported.


Still, our data suggest that ethnic background is an important predictor of finding 1 of the presently known mutations, and the knowledge of ancestries atypical for FMF can suggest the diagnosis of other hereditary periodic fever syndromes.


During repeat transesophageal atrial pacing for recurrent SVT, ventricular fibrillation occurred.


We have confirmed in 5 patients that continuous administration of folinic acid with weekly oral methotrexate prevents improvement of psoriasis.


Prompt correction of hyponatremia by administration of hypertonic saline solution was followed by resolution of all neurologic defects.


Choanal atresia and athelia: methimazole teratogenicity or a new syndrome?


We suggest that meloxicam might have intestinal toxic effects when taken in high doses, because of reduced COX-2 selectivity.


Quinine and its isomer quinidine are well-known causes of iatrogenic hypoglycaemia, due to excessive insulin secretion.


Stevens-Johnson syndrome (SJS) is a serious and potentially life-threatening disease.


Hospital records were reviewed when available.


DESIGN: Descriptive case series.


We describe a patient with acute disseminated encephalomyelitis (ADEM) who was treated with high-dose intravenous methylprednisolone 2 days after onset of neurologic symptoms.


Isoniazid inhibits the metabolism of phenytoin.


OBJECTIVE: To report a case of fatal hyperkalemia owing to succinylcholine administration in a patient with mucositis secondary to chemotherapy.


This 41-year-old woman had been on tamoxifen therapy for 3 years due to breast cancer.


Bisabolol is a sesquiterpene alcohol compound derived from the German chamomile plant, a member of the Compositae family.


The only two studies addressing this issue showed no problems with diagnosis caused by providing narcotic pain relief.


We now present four cases of RSDS in kidney transplant recipients treated with tacrolimus.


Intentional overdose with tiagabine: an unusual clinical presentation.


We report a case of an 11-year-old boy who experienced an anaphylactic reaction after administration of bacitracin ointment.


Radiotherapy has been the predominant treatment in the past, but more recently multi-modality treatments have been utilised.


More than 15,000 cases have been treated by chemonucleolysis world-wide.


This syndrome is not well known but is associated with a high mortality rate.


Rapid warfarin reversal with factor VIIa in an elderly trauma patient with retroperitoneal hematoma.


Foscarnet-induced severe hypomagnesemia and other electrolyte disorders.


Power spectrum analysis of heart rate variability demonstrated marked abnormalities in autonomic nervous system activity.


Lichen planus and acne provoked by gold.


Although this is an intriguing hypothesis, any causative role of etanercept remains unproven at this stage.


It binds to both active and inactive conformations of the ABL gene and is 325 times more potent than imatinib in inhibiting the growth of BCR/ABL cells in vitro (Morelock and Sahn, Chest 1999;116:212-21; Huggins and Sahn, Clin Chest Med 2004;25:141-53).


To treat hepatitis B, interferon alpha was administered until the proximal muscle weakness developed.


This case suggests that coronary arterial involvement in systemic lupus erythematosus may be related to coronary arterial spasm.


A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.


Intravitreal triamcinolone may have had an influence on the exacerbation of retinochoroiditis in the posterior pole of the patient.


The infant died despite intensive resuscitative efforts, including the use of digoxin-specific Fab antibodies.


Cranial MRI showed large asymmetric T2 and FLAIR hyperintense lesions in cortical and subcortical structures.


METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.


Priapism associated with trazodone therapy: case report.


This was later recognised to be a spurious effect due to the introduction of tolmetin.


A euthyroid woman with ophthalmic Graves disease developed endogenous hyperthyroidism coincident with T3 suppression test.


This strategy may be considered in the case of life-threatening VAD associated thrombosis to avoid the need for intracardiac drug delivery or VAD replacement.


However, because diphenhydramine also exhibits type IA sodium channel blockade, cardiac toxicity is also possible.


Methadone is recommended as being free of some of the neuropsychological side effects noticed with morphine, which are attributed to active metabolites.


Vision declined after treatment with methylprednisolone, after which fundus examination became consistent with progressive outer retinal necrosis.


Chemotherapies with QPR/DPR for S. epidermidis pneumonia and voriconazole for chronic necrotizing pulmonary aspergillosis (CNPA) improved her symptoms rapidly without any major complications.


Although chronic arterial hypertension is the leading cause of intracranial hemorrhage, an abrupt rise in systemic arterial pressure in normotensive people may sometimes induce a hemorrhagic stroke.


Silvadene cream and Sulfamylon make up the treatment regimen for one contributor (Dr.


The capacity of zuclopenthixol to induce priapism is thought to be due to its antagonist activity on alpha-adrenergic receptors.


The treatment remains the removal of the offending stimulus along with drug therapy.


Preeclampsia developed in this patient 4 days' postpartum.


Vitreous touch after phacoemulsification.


Sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.


Mostly, reactivation occurs during first 3 months after transplant, especially when risk factors are present.


After administration of granulocyte colony-stimulating factor (G-CSF), multiple infiltrative erythema was identified on the face, thigh, and lower leg.


To our knowledge, this case report is the first documentation of a second PSA bump in a patient treated with external-beam radiation therapy and high-dose rate boost therapy and provides context to address concerns and therapeutic decisions confronting physicians and patients.


Carboplatin and etoposide combined with radiotherapy for limited-stage small-cell esophageal carcinoma: three cases and review of the literature.


CONCLUSIONS: In this study, the hemostatic agent rFVIIa was well-tolerated and behaved in a safe and efficacious manner in all infants treated for life-threatening bleeding and coagulation disorders.


Autopsy examination revealed obstruction of the small pulmonary veins with edematous thickening of the intima.


Mean time between HSCT and diagnosis of MN was 24.4 months.


The patient had been treated with many commonly used medications, including 13-cis-retinoic acid, a relatively new drug with apparent therapeutic benefit in hyperkeratotic dermatoses.


In three other patients, adenosine was associated with prolonged bradyasystole and hypotension.


Patients who have breast cancer (or any other solid tumor malignancy) are at risk to develop a second malignancy.


The implications of this observation for the management of depression, particularly in patients with coexisting dementing illnesses, are discussed.


Five days postoperatively, slitlamp biomicroscopy of the left eye showed an appearance similar to haze after photorefractive keratectomy, with greater density at the center and striae convergent toward the infiltrate (stage 4 diffuse lamellar keratitis [DLK]).


Frequent measurement of prothrombin time, activated partial thromboplastin time, fibrinogen, and thrombin time was used to guide fibrinolytic therapy.


After discontinuing captopril and starting systemic steroids, her symptomatology rapidly improved, and her eosinophilia and radiographic abnormalities both resolved.


Although it is usually clinically silent, such spasm occasionally causes debilitating pain that may be mistaken for more serious disorders.


Ten weeks later, severe congestive heart failure developed which ultimately caused the patient's death.


We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia.


The current case should alert clinicians to investigate pulmonary GVHD as a potential cause of postoperative dyspnea in liver transplant recipients.


Although identifying the cause of contamination is most often viewed in the context of recipient safety, this case illustrates the importance of a thorough evaluation on donor safety.


We observed a patient who developed a maculopapular rash 48 h after beginning oral therapy with this drug, and 2 days later, angioedema and hypotension.


In cases with or without small perforations, the technique minimizes or decreases fluid flow so that the surgeon has a clearer view of these tissues and can perform more thorough and accurate stripping of deeper layers of tissue.


A 47-year-old male patient developed sepsis and monoarticular arthritis following autologous stem cell transplantation for recurrent Hodgkin's disease.


The etiology of Transient Global Amnesia (TGA) is not yet clear.


Acute popliteal artery occlusion after arthroscopic posterior cruciate ligament reconstruction.


The use of real-time ultrasonography enabled us to image this infant's aortoiliac thrombosis in an accurate, noninvasive manner and monitor the effectiveness of thrombolytic therapy.


We describe a case of fibrosing alveolitis, diagnosed by lung biopsy, in a patient receiving amiodarone which responded to corticosteroid therapy.


Tigecycline is a broad-spectrum antimicrobial agent structurally related to minocycline.


A patient with seropositive rheumatoid arthritis developed ascites while taking weekly doses of methotrexate (MTX).


BACKGROUND: Aside from the direct ocular manifestations of tuberculosis, significant vision loss can occur during treatment with agents that have potential ocular toxicities.


Cyclophosphamide (CP) is an alkylating agent widely used in treating cancer and autoimmune disease.


Magnetic resonance of the brain showed a small cortical hemorrhagic infarct.


BACKGROUND: A 55-year-old man with glioblastoma multiforme was treated with continuous, dose-dense temozolomide.


RESULTS: Both patients treated with bilateral subthalamotomy developed unilateral choreoballistic movements immediately after surgery, despite not taking levodopa (L-dopa).


A patient developed restless legs symptoms paralleling the course of interferon-alpha (IFN alpha) therapy for chronic hepatitis C.


We report the development of scrotal ulcer in a patient with acute promyleocytic leukemia (APL) within 10 days of treatment with ATRA at a dose of 40 mg orally twice daily.


Fomepizole (4-methylpyrazole; Antizol) is used increasingly in the treatment of methanol toxicity in adults.


Enteral nutrition is less costly than TPN and maintains the structural and functional integrity of the intestinal mucosa.


METHODS: We describe a patient with chronic hepatitis B viral infection and RA treated with etanercept.


The authors compare the case with the 8 other published cases of postinjection epidural hematomas in patients with coagulopathy, and the specific risk factors that may have contributed to the hemorrhagic complication in this patient is analyzed.


A patient is described with a 25-year history of disabling, and at times life-threatening, anorexia nervosa alternating with major depression associated with suicidal ideation.


A patient with adenocarcinoma of the prostate with bone metastases experienced dyspnea possibly related to the ingestion of these tablets.


Hypersensitivity to zonisamide was confirmed by the skin patch test.


On postoperative day 114, however, he was diagnosed with recurrent CMV infection.


The case report illustrates the need for flexible individualized dosage schedules, similar to other neuroleptics.


The remaining four neonates had clinical signs of gastric obstruction, but no radiologic or pathological examinations were performed.


The aim of this paper is to report the case of rosaceiform eruption induced by erlotinib in an 81-year-old-man and to discuss the pathogenetic role of Demodex folliculorum mites, found in the present patient, using skin scraping.


CONCLUSIONS: When generic substitution of carbamazepine is required, serum concentrations should be carefully monitored.


The patient was initially treated with hydration and furosemide but developed congestive heart failure.


Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis.


Intraocular blastomycosis: case report and review.


Two cases, one of leukemia and one of a trophoblastic testicular teratoma, are described in which hypoglycemia occurred as a terminal event.


The clinical findings, radiological features, and results of pulmonary function tests may be enough to diagnose gold-related pneumopathy.


That feature underscores the heterogeneity of the FAD clinical phenotype.


There have also been some spontaneous reports of serious ventricular dysrythmiasis with prolongation of the QT intervals, rarely associated with death.


Salicylate hepato toxicity in rheumatic fever.


In the second patient, acute renal failure necessitated hemodialysis.


Severe hyperlipidemia was reversed by changing the carnitine deficient diet (Ensureliquid) to a carnitine-containing diet.


We report a case of generalized cutaneous sclerosis associated with muscle and oesophageal involvement in a patient exposed to herbicides containing bromocil, diuron and aminotriazole.


After corticosteroid withdrawal, a tuberculin skin test became strongly positive and pericardial effusion was considered to be of tubercular origin.


Our findings suggest that hyperkalemia can develop with the use of low-dose heparin, within seven days of initiating heparin therapy, and that patients with diabetes mellitus or chronic renal insufficiency are especially predisposed to this complication.


Just over 1 year following completion of his treatment, falling platelet and white cell counts were associated with the development of dysplastic features in his bone marrow and a rising blast cell count, culminating in the development of acute myeloid leukemia (AML).


This study seems to indicate that anti-retroviral-induced lipodystrophy and hypertriglyceridemia may be associated to some racial factor.


In both cases routine stool examinations prior to steroid therapy were negative for cysts or trophozoites of E. histolytica.


No recurrence was seen during the follow-up period (3 and 4.5 years).


Possible mechanisms by which clonidine decreases spasticity are described, probable mechanisms of induced bradycardia are reviewed, and specific treatment recommendations for the use of clonidine in spinal cord injured patients are presented.


This case, which afforded a unique opportunity to follow the consequences of weakening scapular stabilizers over time, provides evidence for the etiologic role of scapular dyskinesis in SIS and shows that SIS is a potential complication of botulinum therapy for myofascial pain involving the scapular stabilizers.


Pure red cell aplasia (PRCA) is a rare complication after ABO-incompatible allogeneic stem cell transplantation, but its mechanism is still unknown.


The first patient is undergoing hemodialysis and, though responding to sunitinib, is having significant fatigue and hypertension.


Relapse occurred 13 1/2 months later, and therapy with adriamycin was restarted.


After administration of Oxybutynin concomitantly with an increase in the dose of Dantrolene, she presented the clinical symptoms and laboratory finding of Carbamazepine intoxication.


After 20 months, the patient presented clinical features of primary hypothyroidism.


An apparent link is described between the use of MMF with prednisone to treat pemphigus vulgaris and the development of red blood cell anemia.


At 10.5 years rhGH therapy was started and height gain of 26 cm was observed after 2.7 years of treatment.


The reflex myoclonus had a 150-ms refractory period.


We highlight the importance of physiological hormonal modification and hormonal therapies on the course of MA.


Two patients on long-term lithium therapy developed the nephrotic syndrome.


Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.


An episode of subacute encephalopathy after the infusion of a moderate dose of methotrexate (1500 mg/m2) (MTX) is reported in a young adult with metastastic gastric cancer.


Toxic hepatitis due to combination therapy with methotrexate and etretinate in psoriasis.


Earlier reports on the use of etanercept or infliximab in patients with rheumatoid arthritis, psoriatic arthritis, or juvenile rheumatoid arthritis suggested an increased risk of demyelinating disease.


A 17-year-old epileptic was admitted to the hospital in a confused state.


Carmustine (BCNU), a nitrosourea derivative, is an antineoplastic agent used recently for the treatment of human solid tumors and lymphomas in high doses with autologous bone marrow transplantation.


He developed postural headache and severe nausea and vomiting after a diagnostic lumbar puncture.


BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.


Even in a patient undergoing posterior lumbar interbody fusion using a metal cage, magnetic resonance imaging (MRI) might be able to diagnose epidural abscesses and diskitis when titanium alloy implants are used.


After 6 months of treatment, systemic lupus erythematosus-related symptoms disappeared and anti-double-stranded DNA returned to normal.


Postoperatively, he was started on sulindac (Clinoril) 100 mg twice a day.


Trans-catheter hepatic arterial injection of lipiodol soluble anti-cancer agent SMANCS and ADR suspension in lipiodol combined with arterial embolization and local hyperthermia for treatment of hepatocellular carcinoma.


Gangrene of the fingertips after bleomycin and methotrexate.


(1) Acute rehabilitation of a 63-year-old woman with rheumatoid arthritis after replacement of both preexisting knee endoprostheses in one session and removal of the left hip endoprosthesis due to infection and sepsis.


Aripiprazole in treatment-refractory schizophrenia.


Early histopathologic changes in purple glove syndrome.


Thus cabergoline may cause similar pleuropulmonary abnormalities to bromocriptine.


The renal consequences of indinavir-associated nephrotoxicity are uncertain.


Inhaled drugs must be used regularly.


The patient presented with fulminant microangiopathic hemolytic anemia and thrombocytopenia within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole.


Nasal reconstruction using 20 mg/ml cross-linked hyaluronic acid.


Phenytoin (Dilantin) is typically employed as prophylactic anticonvulsant in this setting.


We report a 46-yr-old woman with ovarian carcinoma who developed porphyria cutanea tarda while undergoing treatment with cisplatin and cyclophosphamide.


Standard care includes the administration of dextrose, glucagon, and diazoxide.


Chemotherapy-induced Raynaud's phenomenon leading to acral gangrene has rarely been reported.


At autopsy, blood, brain, and other tissue concentrations of fluoxetine and norfluoxetine were several-fold higher than expected based on literature reports for overdose situations.


Severe autoimmune hemolytic anemia following rituximab therapy in a patient with a lymphoproliferative disorder.


Clinicians should be alert to these potential problems in the geriatric population.


This observation adds another dimension to the previously reported renal complications of nonsteroidal anti-inflammatory agents, especially zomepirac.


It is known that the intramuscular injection of human chorionic gonadotropin (hCG) lowers the threshold for motor evoked responses (MEPs) in the first dorsal interosseous (FDI) muscle to transcranial magnetic stimulation (TMS) in humans.


In this report, we describe a rare case of bilateral cryptorchism that did not come to the attention of the physician to implement effective substitution with testosterone until much later in adult life.


OBJECTIVE: The purpose of this study was to report the concomitant occurrence of multiple squamous cell carcinomas and diffuse nail hyperpigmentation associated with hydroxyurea treatment, and to describe a successful therapeutic approach using imiquimod 5%.


At the time of admission, he was not receiving any drugs and denied any previous exposure to a hepatotoxic agent.


Even if the single and total dosage of antiestrogens given to the patient is sufficient to cause tamoxifen retinopathy, this diagnosis can be excluded because, in tamoxifen retinopathy unlike in the case presented here, the deposits are not distributed in all retinal layers.


Mitral valve prolapse is usually a benign condition, however, serious complications have been reported to be associated with it.


Arsenic trioxide has recently been introduced as a promising new agent to treat refractory acute promyelocytic leukemia (APL).


Liver biopsies taken while symptomatic showed portal fibrosis progressing to cirrhosis.


Other drugs used simultaneously were ruled out by patch and challenge tests.


He was treated with broad spectrum antibiotics, red cell and single donor platelet transfusions and strict parenteral nutrition.


During cytotoxic treatment of a child with leukemia we describe the longitudinal course of ionized calcium in a complex syndrome of hypocalcemia and hypoparathyroidism.


On the 4th day after the infusion, VWF antigen and VWF ristocetin cofactor increased to 40 and 78% of the control, respectively, and dental extractions were performed successfully.


Endoscopic examination revealed a tumor resembling advanced gastric cancer.


First case report.


Despite effective thrombolysis, the plasma fibrinogen level rose during streptokinase administration and reached extremely high values 72 hours later.


The visual acuity and the RPE atrophy remained stable over the follow-up period of 3 years.


Gemcitabine therapy has been associated with radiation recall reactions when used in the treatment of carcinoma.


A 16-year-old white male with acute biphenotypic leukemia developed evidence of the eosinophilia myalgia syndrome associated with total parenteral nutritional support with solutions containing tryptophan, which were given during his initial induction chemotherapy and also after autologous marrow transplantation.


All symptoms disappeared within 24 h.


The evaluation, causes, and differential diagnosis of alopecia in a black woman are discussed.


Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.


Then, she again started taking theophylline (75 mg twice daily), and over 2 days reached a steady state serum theophylline level of 12.8 to 14.4 micromol/L (2.3-2.6 microg/mL).


We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.


Initial vitreous cultures were negative.


The identification and quantitation procedures of zolpidem in postmortem tissues included dual-column gas chromatography (GC) with nitrogen-phosphorus detection and GC-mass spectrometry.


We report three cases of abdominal wall metastases from ovarian cancer after laparoscopy.


Fever caused by the use of furosemide was proved; the fever resolved after discontinuation of this medication and recurred after its reintroduction.


In two of the patients there appeared to be a correlation between the severity of the psoriasis and the dosage of interferon.


CASE PRESENTATION: Three cases of Leishmania infantum leishmaniasis in corticosteroid (CS)-treated patients are reported: an isolated lingual leishmaniasis in a farmer treated with CS for asthma, a severe visceral leishmaniasis associated with cutaneous lesions in a woman with myasthenia gravis, and a visceral involvement after cutaneous leishmaniasis in a man receiving CS.


However, adenosine shortens the antegrade refractoriness of accessory atrioventricular connections and may cause acceleration of the ventricular rate during atrial fibrillation.


We present a patient who had a superior sagittal sinus thrombosis in addition to his PDPH.


Report of a case.


A partial empty sella was found on a computed tomography scan of the hypothalamic-pituitary region.


Beginning ductopenia was present in two, suggesting that itraconazole might be responsible for the occurrence of prolonged drug-induced cholangiopathy.


Clonazepam, thioridazine, beta-blockers, anticholinergics, and bromocriptine did not ameliorate his akathisia.


These results indicate that lithium may cause biochemical hyperparathyroidism.


Treatment was completed without further complication by using amphotericin B and ketoconazole concurrently.


The association between the use of cyproterone acetate and liver abnormalities is poorly documented.


PATIENT: An 8-yr-old with acquired immunodeficiency syndrome with a large organized intraatrial thrombus at the tip of an indwelling central venous catheter placed for total parenteral nutrition 2 months before presentation.


He had priapism following the use of olanzapine.


Three infants with supraventricular tachycardia and congestive cardiac failure were given verapamil intravenously.


Radiation recall related to gemcitabine has been reported in lung and breast cancer.


The authors report a case of focal myocardial necrosis, presenting clinically as an acute myocardial infarction during the administration of the antineoplastic drug, amsacrine, in a patient without coronary artery disease.


By contrast, PDCs were present at very low levels in atopic dermatitis and not detected in normal human skin.


We report a case of bacterial keratitis that occurred after laser-assisted subepithelial keratectomy.


The adverse hematologic effects are usually transitory and pancytopenia is not frequent.


She experienced intense pain in the first postoperative week and obtained topical oxybuprocaine for pain relief.


Aluminum intoxication developed in three infants with azotemia who were not undergoing dialysis and who had been treated with aluminum hydroxide from the first month of life.


Development and course of subjective and objective phenomena seem to be typical for patients in whom Ukrain could induce long-term complete remission.


Thrombotic microangiopathy (TMA) is a serious toxicity associated with a small number of antineoplastic agents.


Most importantly, it occurs only after high doses of mannitol (> 200 g/day or cumulative dose of > 400 g in 48 hours), but not at lower doses.


Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis.


Meningitis can be caused in experimental performing a lumbar puncture (LP) after bacteraemia.


RESULTS: Of the 74 neonates evaluated, 65 had no signs of gastric obstruction and were considered normal; 5 had clinical and radiologic or pathological evidence of gastric obstruction consistent with the presence of antral mucosal hyperplasia.


Two cases of sirolimus-associated pneumonitis have been reported after cardiac transplantation.


We present herein the case of a 56-year-old woman in whom bilateral and recurrent SSP was caused by the rupture of pulmonary lacunae induced by chemotherapy, given for bilateral lung metastases secondary to breast carcinoma.


Its safety, even in these extreme conditions, is particularly reassuring.


However, the similarities between patient reports and reports from healthcare professionals in most frequently reported ADRs and most frequently reported drugs are striking.


We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.


A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed.


We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.


As bilateral subthalamic nucleus (STN) stimulation produced improvement in his motor symptoms, his drug dosages were reduced postoperatively.


An investigation of malaria in a US patient without recent travel established Plasmodium falciparum molecular genotype identity in 2 patients who shared a hospital room.


The exophthalmos improved dramatically within 72 hours of the withdrawal of lithium.


By contrast, the appearance of a hypercalcemia has yet to be described.


She had been treated by Carbamazepine 1000 mg/day for neuropathic pain for 2 years without clinical or laboratory signs of toxicity.


Anaphylactic reaction to recombinant insulin-like growth factor-I.


Although a causative association between trastuzumab and this patient's pulmonary syndrome was not proven, the potential for this toxicity should be considered.


Patients with large pelvic tumor loads are, according to existing classifications, at high risk to die and to develop drug resistance.


Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).


Bone marrow biopsy revealed no evidence of neoplasia.


These medications do not require medical prescriptions, so often parents use them, bypassing paediatricians.


Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.


Growth hormone and respiratory compromise in Prader-Willi Syndrome.


In both instances, reversion of intraventricular conduction to normal occurred within 72 hours, coinciding with clearance of carbamazepine from the blood stream.


A liver biopsy shortly after abstinence showed extensive pericellular fibrosis, but a biopsy after 6 years showed very mild fibrosis.


Resin hemoperfusion for chloramphenicol intoxication.


All patients underwent classic therapy.


However, the toxicity profile of leflunomide in patients with underlying GVHD remains to be defined.


OBJECTIVE: To describe a case of cefazolin-induced leukopenia in a critically ill patient who developed this adverse reaction upon rechallenge with cefoxitin.


A lumbar epidural catheter was placed preoperatively for pain management.


The potential development of SJS/TEN, a severe life-threatening illness, emphasizes the need for judicious use of TMP-Sx and close monitoring and follow-up for patients who were given TMP-Sx for SSTIs.


A three-year old female Whippet was hospitalized due to a multiple fracture and displacement of the left scapula caused by a recent car accident.


Successful treatment of oral lichen planus-like chronic graft-versus-host disease with topical tacrolimus: a case report.


Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma.


Neutropenic enterocolitis and cecal perforation in acute lymphatic leukemia.


The delirium was not affected by administration of alprazolam.


In one case the patient's reason for attendance was to obtain further supplies of analgesics.


A 59-y-old with a history of chronic renal failure on hemodialysis was diagnosed with herpes zoster and begun on 800 mg acyclovir 5 times daily.


A case of a female with advanced squamous carcinoma of the vagina is presented.


This investigational compound was employed in a 50-year-old patient with acute myelomonocytic leukemia complicated by prolonged, treatment-induced granulocytopenia and documented Aspergillus flavus sinusitis with signs of disseminated aspergillosis.


Here we report ramipril-induced cutaneous vasculitis in a patient who required steroid therapy to control it.


Sedation improved at least moderately in 5 of the patients and mildly in 1 after they began taking donepezil.


Patients receiving amifostine who develop only fever should be evaluated for an adverse drug reaction, as well as for sepsis and fevers of neutropenia, and it may be necessary to discontinue the drug.


The latent period of therapy-related MDS (t-MDS) from the time of diagnosis of ATL was approximately 35 months.


Acute acoustic nerve palsy associated with vincristine therapy.


A study of nineteen immunocompromised patients with extensive skin lesions caused by Pseudomonas aeruginosa with and without bacteremia.


As levodopa abuse has only been described in patients with PD, it was suspected to be promoted by central dopamine depletion (with consequent sensitization of dopamine receptors).


Although taxol has shown significant activity in advanced ovarian cancer, peripheral neuropathy is likely to become the major dose-limiting toxicity.


Physicians should therefore be aware of its occurrence and carefully monitor serum levels of CPK, GOT and GPT during the treatment of diabetes insipidus with clofibrate, especially in patients with associated hypothyroidism, latent or overt, which possibly favors the development of myopathy.


Recurrent hypotension immediately after seizures in nortriptyline overdose.


Fungal septicaemia is a serious and potentially fatal condition.


An MRI showed T2 signal change in the conus medullaris gray matter at T11-12, consistent with an acute vascular infarct.


Drug-resistant tuberculosis after gastrectomy.


Sirolimus-eluting stent thrombosis several years after clopidogrel discontinuation.


In some cases, removal of the necrotic tissue may be necessary to cure the infection.


To our knowledge, this is the first case of polymyositis associated with dilated cardiomyopathy after the administration of interferon in a patient with hepatitis B.


These cases illustrate a previously unrecognized and potentially causal relationship between tumor necrosis factor-alpha inhibition and reactivation of latent melanoma.


CASE HISTORY: A 6-year-old white boy with a history of developmental delay was found to have an infiltrate in his right upper lobe on a chest radiograph obtained during evaluation for thoracic scoliosis.


Amphotericin B nephrotoxicity in humans decreased by salt repletion.


The masses were soft, painless, and located around her insulin injection sites.


This report describes the analytical techniques and significance of the zolpidem findings.


Pulmonary fibrosis is a severe complication associated with bis-chloronitrosourea (BCNU) therapy.


No concrete predisposing factor was found to be associated with the occurrence of the lesions on the face.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


METHOD: A case report.


Acute graft-versus-host disease of the lung after liver transplantation.


The lung had become too stiff for the anesthetic circuit bag to be squeezed by hand.


Aromatic anticonvulsants, sulphamides, minocycline and more rarely carbamazepine are the principal responsible drugs.


This agent is, however, associated with a rare but serious risk of lactic acidosis.


Anaphylactic reaction to oral prednisone: a case report and review of the literature.


Medical evaluations included computerized tomography, lumbar puncture, complete blood counts, serum chemistries, and serologies.


Neonates who receive prostaglandin E1 at recommended doses for more than 120 hours should be closely monitored for evidence of antral hyperplasia.


A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.


Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.


This case of linezolid-associated acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with linezolid raises concerns about the presumed renal safety of this drug.


Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased.


Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.


A 72-year-old woman with a history of thyrotoxicosis presented with sore throat and fever two weeks after starting carbimazole.


BACKGROUND: With the pharmacokinetic advantages of intraperitoneal chemotherapy delivery and the increased popularity of immunotherapy and gene therapy, intraperitoneal catheters have moved to the forefront as a delivery system in cancer treatment.


Immunohistochemistry confirmed some pigment-containing cells to be macrophages.


We report here the pharmacodynamics and pharmacokinetics of an accidental triamcinolone acetonide (TCA) overdose.


The conditions may develop months or possibly years after cessation of intake of the drug and further cases may occur, although practolol has been withdrawn from use.


It was not detected either on FA or ICGA with the conventional camera.


Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.


OBJECTIVE: To report a case of phenolphthalein-induced toxic epidermal necrolysis (TEN) in a patient maintained on several other medications more commonly known to be associated with TEN.


The authors suggest that in the absence of any proven benefit of itraconazole prophylaxis, and given the interaction of this drug with vincristine leading to severe and even potentially fatal toxicities, the combination use of these drugs should be avoided.


Erosion of an intraperitoneal chemotherapy catheter resulting in an enterovaginal fistula.


On examination, multiple erythematous and brownish hyperkeratotic papules were seen in both axillae.


The median age was 31 yr (range 2-93).


A urinalysis was significant for protein 3061 mg/dl, ketones 15 mg/dl, blood 2+, leukocytes 26-50/high-power field, and a protein:creatinine ratio 24.9.


CASE REPORT: We report a 20-year-old female patient with Crohn's disease who developed WE as a result of thiamine deficiency.


CONCLUSIONS: The piloerection observed after the replacement of fluvoxamine with milnacipran in this patient appears to have been due to an increase in the alpha(1)-adrenoceptor occupancy by endogenous norepinephrine induced by milnacipran.


CONCLUSION: beta-blockade treatment was well tolerated and may be beneficial in relieving symptomatic steroid-induced left ventricular outflow tract obstruction in premature infants.


Progressive outer retinal necrosis is a necrotizing herpetic retinopathy usually seen in immunocompromised patients.


In both cases, high fever, skin rash, liver dysfunction and atypical lymphocytosis developed 3 weeks after initiating treatment with SASP.


The patient had been free of interstitial pneumonitis for 14 months, but died of pneumothorax.


Many women are diagnosed with early stage breast cancer each year who are potential candidates for adjuvant therapy.


AIM: To report a patient with diabetic rubeosis who suffered from acute retinal ischemic change and stroke after intravitreal injection of bevacizumab.


Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.


The problem of differential diagnosis and treatment.


Diagnosis of hypothyroidism during treatment can be difficult because of the common side effects of alpha interferon.


Analysis of the HLA system revealed the positivity of locus DR5, associated with classical KS.


Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.


We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).


After an uneventful tonsillectomy and extubation, stridor and respiratory distress developed.


If untreated, or misdiagnosed and treated incorrectly, there may be loss of visual acuity.


Spinal shock protocol with high-dose methylprednisolone was begun without change.


We believe that the infection was due to asymptomatic ethmoid sinusitis.


DISCUSSION: The occurrence of priapism in our patient was related to zuclopenthixol.


After discontinuation of danazol the diabetes completely resolved.


Pulmonary eosinophilia or granulomas, classically seen in previously reported cases of methotrexate pneumonitis, were not observed.


In the other case, a 62-year-old woman, almost all the symptoms subsided after 14 days, and oral dyskinesia persisted for only one additional month.


In conclusion, patients older than 60 years should have baseline electrolyte measurements before starting therapy with an antidepressant, and these should be monitored not only in the first weeks of treatment, but throughout the full course.


Recurrent spontaneous intracerebral hemorrhage in a congenitally afibrinogenemic patient: diagnostic pitfalls and therapeutic options.


Physicians should be cognizant of this potential complication in patients receiving thalidomide or thalidomide-like drugs who present with fever and pulmonary infiltrates and fail to improve despite treatment with broad-spectrum antibiotics.


During attempted conversion from aripiprazole to clozapine, the patient experienced a significant reduction in psychiatric features.


Paradoxical enlargement of intracranial tuberculomas during treatment of tuberculous meningitis: report of a case.


Although this combination agent has been associated with a hypersensitivity syndrome involving cutaneous skin eruptions, pediatric cases of TMP-SMX-induced hepatotoxicity are rare.


Tracheobronchial obstruction was ruled out by investigation with a fiberoptic bronchoscope.


Clinicians frequently encounter patients who present with borderline personality disorder (BPD) and prolonged and/or pronounced psychotic symptoms of an atypical nature.


Detailed pathological study of a case.


Haptic repositioning was performed in the right eye.


Central pontine myelinolysis (CPM) is removal of myelin material from neural elements in a way that is not clearly known as yet.


Early treatment of Niemann-Pick type C patients with cholesterol-lowering agents appeared to have short-term beneficial effects.


Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.


Late development of diabetes mellitus after interferon-alfa and ribavirin therapy for chronic hepatitis C: a case report.


The second is a 29-year-old man with CD in whom nodular sclerosing Hodgkin's lymphoma was diagnosed 3 weeks after infusion with infliximab.


Systemic chemotherapy induced complete regression of the soft tissue lesion.


Compared with standard interferon alfa injections, this preparation has a longer half-life allowing for once-weekly injections and superior antiviral efficacy in the treatment of hepatitis C when used in combination with ribavirin.


In all cases, response to corticosteroids was unsatisfactory and three of these patients ultimately died from complications that ensued from prolonged immunosuppressive therapy.


METHODS: The number of reports received, age and sex of the reporters, characteristics of the most frequently reported drugs and characteristics of the ADRs (most frequently reported ADRs, seriousness, outcome) in a 3-year period (April 2004-April 2007) were compared between patient reports and reports from healthcare professionals.


Inflammatory mononuclear cells and granulocytes typically seen in patients with diffuse lamellar keratitis (DLK) were absent.


With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.


The patient considered C&C caused him less discomfort and disruption.


Late onset subgaleal hemorrhage infection with Streptococcus pneumoniae?


The responsibility of CCNU in the pathogenesis of pulmonary fibrosis seems very likely.


Hepatic veno-occlusive disease (VOD) with complete occlusion of liver venules after tandem autologous stem cell transplantation-- successful treatment with high-dose methylprednisolone and defibrotide.


Current trends toward intensive insulin therapy for rapid near-normalization of blood glucose levels will increase the recognition of this entity.


A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis was hospitalized because of fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine.


Case report: role of granulocyte colony stimulating factor in radiotherapy.


No adverse effects of joint toxicity were detected.


For this reason, olanzapine was considered strongly associated with this patient's apparent NMS episode.


The patient underwent treatment with corticosteroids, and after 2 months, the clinical examination revealed an improved clinical situation with a disappearance of the hypoesthesia but with a persistence of the pain.


Interstrain differences in the development of pyometra after estrogen treatment of rats.


Administration of hydrocortisone reversed the mental status changes seen in this patient.


The authors describe a 6-year-old boy who developed pulmonary tuberculosis during intensive chemotherapy for acute myeloblastic leukemia (AML).


Thyroid function remained normal when treatment was discontinued after five months although iodine excretion was still 50 times higher (2.5 mg/day) than in normal age matched children.


Further studies should be encouraged to evaluate the usefulness of CITB for other patients with severe and otherwise untreatable tardive dystonia.


PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.


Mitomycin C is a powerful antineoplastic agent.


Further histologic documentation in other cases is necessary to strengthen our current findings.


Alopecia areata universalis after phenobarbital-induced anti-convulsant hypersensitivity syndrome.


When the therapy was discontinued, the frequency and amplitude of the myoclonus increased, and synchronous and weak myoclonus also was observed in the left abdomen.


Fatal digoxin poisoning: an unsuccessful resuscitation with use of digoxin-immune Fab.


No side effects were observed and improvement was sustained during a mean of 7 months (range 3-12 months) follow up.


Thirteen bacteremias and 25 nonbacteremic infections caused by Pseudomonas spp. occurred in 22 of 236 children with human immunodeficiency virus infection with a rate of infection of 0.098 (bacteremia, 0.030) per patient year.


Essential thrombocythemia (ET) is an uncommon myeloproliferative disorder, which is thought to develop from a multipotent stem cell.


Physicians should be aware that indinavir nephrolithiasis may cause papillary necrosis.


The occurrence of this reaction in a mother and daughter on ingestion of tuna fish is reported.


Interstitial pneumonitis and alveolar hemorrhage complicating use of rituximab: case report and review of the literature.


The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.


18 perfusions were performed on 15 patients with stage II disease, that is with tumor growth restricted to an extremity including possible regional node metastases.


Met-Hgb should be suspected in patients with cyanosis that does not respond to administration of oxygen and who have a discrepancy in oxygen saturation measured by pulse oximetry compared with the arterial partial pressure of oxygen (PaO2) determined by blood gas analysis.


Intrauterine contraceptive device-associated pelvic actinomycosis caused by Actinomyces urogenitalis.


The first patient, who received gemcitabine for treatment of a carcinoma of the pancreas, required hemodialysis for 6 months.


A transdermal scopolamine patch is an effective medication for relieving motion sickness, treating nausea and vomiting from chemotherapy and decreasing withdrawal side-effects from wearing off opioids.


After low-molecular-weight heparin was substituted for unfractionated heparin, the thrombocytopenia resolved and although the pregnancy was lost, the patient made a full recovery.


These findings mean that the effect of the MP pulse therapy on renal function depends on the clinical state of the patient and that renal deterioration after the pulse therapy may be more marked in patients who are more nephrotic and more impaired in renal function and suggest that increasing sodium and water retention during an MP therapy and the associated renal interstitial edema, proposed as one of the mechanisms of acute renal failure occurring in patients with minimal-change nephrotic syndrome, may be responsible for the MP-induced transient renal failure.


Stage 4 diffuse lamellar keratitis after laser in situ keratomileusis Clinical, topographical, and pachymetry resolution 5 years later.


Both colchicine and statin therapy may be associated with myopathy, which usually occurs after several months of therapy.


We describe a patient with extranodal non-Hodgkin lymphoma who developed systemic candidiasis after treatment with a cyclophosphamide-based chemotherapy regimen.


We conclude that after an accidental overdose in this patient, body TCA disappearance was strongly prolonged due to a very slow (absorption) half-life of the drug in comparison to a therapeutic dose.


This toxic effect was attributed to lomustine and was not seen in patients treated with carmustine alone.


Chloroquine-induced bilateral ptosis.


Heparin therapy, adjusted according to the patient's clinical status and the results of coagulation studies, rapidly controlled the manifestations of DIC.


BACKGROUND: Because of its unique mechanism of action and safety profile, imiquimod, a topical immune response modifier, is used for many benign and malignant dermatologic conditions.


In this study, we report the development of severe autologous GVHD in five patients who underwent HPCT for multiple myeloma.


Abnormal retinal function associated with isotretinoin therapy for acne.


Nitric oxide, a potent smooth muscle relaxant, has been shown to be involved in the initiation and maintenance of erections; future research involving specific inhibitors of this chemical is indicated for the possible treatment of intraoperative penile erections.


'Spontaneous' hypertensive episodes with monoamine oxidase inhibitors.


We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.


Fulminant hepatic failure associated with bicalutamide.


She received chemotherapy according to the previously described modified St.


A trial of combination chemotherapy using mitoxantrone-cyclophosphamide was started in 1983.


Our report discusses the possible contribution of antihistamines and antiallergenic drugs to the Brugada type ST-segment changes.


A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain.


The patient recovered completely following withdrawal of antacids and sucralfate and short-term treatment with phosphate.


This report describes a case of paradoxical, intravenous valproic acid-induced seizure exacerbation in a child with juvenile absence epilepsy, documented by video-electroencephalography.


This article discusses the reasons why this case may represent serotonin syndrome rather than clozapine withdrawal and the possible pharmacologic mechanisms involved.


Adverse reactions to reserpine were studied in 231 hospitalized medical patients who received the drug.


To our knowledge this is the third article presented in the literature so far.


Bone marrow cytogenetic study confirmed the deletion of the long arm of chromosome 11, as reported in myeloid leukemia.


Five hours later he developed a dramatic hypersensitivity reaction including high fever, pulmonary edema, cyanosis, and convulsions.


The marked thrombocytosis was nonresponsive to hydroxyurea therapy.


Salicylate intoxication was excluded, and theophylline was finally incriminated.


We present a case report of a cytomegalovirus (CMV)-seronegative, 58-year-old male who received a CMV-seropositive donor liver transplant without CMV prophylaxis.


Triazolam-induced nocturnal bingeing with amnesia.


GVHD is a recognized complication of autologous hematopoietic progenitor cell transplantation (HPCT), but has typically been reported to respond well to primary therapy with corticosteroids.


Failure of plasmapheresis, corticosteroids and thionamides to ameliorate a case of protracted amiodarone-induced thyroiditis.


The possibility of severe rhabdomyolysis should be considered in a patient with water intoxication due to massive ingestion of caffeine-containing beverages.


Mean duration of therapy was 5.5 yrs.


An unusual cause of hypocalcaemia: magnesium induced inhibition of parathyroid hormone secretion in a patient with subarachnoid haemorrhage.


We report a case of glaucoma induced by doxetaxel therapy for metastatic breast cancer.


Thus, the risk appears to be confined to women over 50 because, in contrast, in women under 50 there was no statistically significant increase in the risk of endometrial carcinoma.


Gemcitabine, a nucleotide analog, recently was implicated in several cases.


Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.


Based on these findings, the patient was diagnosed with DRESS/DIHS caused by zonisamide.


Autoimmune thyroid disease is a common side-effect of interferon-alpha (IFN-alpha) treatment of viral hepatitis C.


Both patients were in a state of neutropenia.


We report four cases of sensorimotor axonal neuropathy in children aged 10-15 years, treated with thalidomide for myxopapillary ependymoma, Crohn's disease and recurrent giant aphthous ulceration.


Dystonic symptoms began two to three weeks after introduction of therapy and subsided within three weeks after discontinuation.


Endoscopic rinsing was performed, and multiple small yellowish microgranulations, less than 1 mm in diameter, were observed in the lateral ventricles and the third ventricle.


Soon after, the SvO2 decreased progressively from 55 to 39%.


All four patients in this study were treated with alcohol neurolysis of the superior cluneal nerves.


Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity.


Due to the increasing use of TMP-SMX in children, clinicians should be aware of this potentially life-threatening, immunemediated hypersensitivity reaction.


Early detection of this rare adverse reaction may prevent acute renal insufficiency.


Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.


In both, skin biopsy showed a cell-poor subepidermal vesicle with festooning of the dermal papillae.


Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome.


Four months after receiving an orthotopic liver transplant, a 51-year-old man was admitted for progressive liver failure and severe hepatocellular necrosis thought to be due to tacrolimus.


This case report shows an unusual complication of mandibular second premolar root canal overfilling.


We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.


The pharmacokinetics of antineoplastic drugs in obese patients are poorly understood and are not sufficient to create standards for rational dosing.


In addition, there were findings suggesting a possibly immunologically mediated mechanism.


The plasma concentrations of noradrenaline, adrenaline, and dopamine increased to 26.4, 1.8, and 36.2 micrograms/l, respectively.


They recovered within three and four weeks, respectively, with complete remission of the radiologic abnormalities and had an uneventful follow-up after discharge.


A case report with comment on the toxicity of mebendazole.


Antiepileptic drug hypersensitivity syndrome: in vitro and clinical observations.


We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan.


Chemotherapy for the malignant lymphoma was done after withdrawal of cyclosporine A and mizoribine, and thyroidectomy was performed for thyroid carcinoma.


Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis.


One not so well documented consequence of this treatment is avascular necrosis or osteonecrosis of the underlying bone.


Development of rickets in association with parenteral nutrition is described in four premature infants having gestational ages of 26-31 wk.


Examination showed severe dyspnea with severe mitral regurgitation associated with tricuspid regurgitation.


Both of the mothers were on methadone maintenance for narcotic dependency prior to the diagnosis of pregnancy.


Acute isoniazid neurotoxicity in an urban hospital.


Heparin-induced hyperkalemia.


In patients with methotrexate-induced anaphylaxis, discontinuation of treatment may increase the risk of death due to cancer progression.


Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.


A case of severe hyperlipidemia caused by long-term tube feedings.


We report the first case of chlorambucil-induced DRESS syndrome in a 70-year-old man recently diagnosed with chronic lymphocytic leukaemia.


Many clinicians appear to be concerned about the potential hepatotoxicity of the opiate antagonist naltrexone (NTX) and this may be one reason why it is not used more widely in treating both heroin and alcohol abusers.


DATA: A 16-year-old girl was treated with risperidone for mood lability and impulsivity at a community hospital.


A scan of fetal neck region is recommended in patients with current or previous history of thyroid disease, or if neck extension is noted on routine examination of fetal spine.


The authors describe a 65-year-old man who, after 7 years of complete remission from lung cancer, was found on routine oncologic follow imaging to have lesions on several vertebral bodies.


Clinical manifestations range from asymptomatic to fulminant in nature.


Liver abscess caused by an infected ventriculoperitoneal shunt.


Although free of disease, the patient has a subcortical dementia and is unable to work.


Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.


A conjunctival biopsy revealed invasive squamous cell carcinoma, with orbital invasion on computed tomography scan.


Several clinical parameters indicate a remarkable improvement in the clinical courses of those patients in recent years: weaning time, extubation rate, and improvement of additional organ failures were all significantly better in patients treated after the emergence of new antimycotic agents, resulting in prolonged overall survival.


Erosion of psoriatic plaques: an early sign of methotrexate toxicity.


Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported.


When the treatment was completed, her depression substantially improved and her posture became completely upright.


Diagnostic procedures did not reveal any liver, kidney, splenic, or pancreatic abnormalities.


Possible causes and difficulties in diagnosis were reviewed.


PURPOSE: To describe a patient with iatrogenically induced central retinal vein occlusions secondary to serum hyperviscosity from intravenous immunoglobulin administration.


CONCLUSIONS: Although budesonide may be beneficial because of its anti-inflammatory effects, clinicians should be alert to its potential for causing contact dermatitis.


Venous thrombosis and congenital absence of inferior vena cava in a patient with menorrhagia and pelvic pain.


He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.


We report a patient with type 2 diabetes mellitus who, while treated with the antitumor necrosis factor-alpha blocking agent etanercept for severe plaque psoriasis, experienced persistent hypoglycemia requiring the lowering and eventual elimination of his previous insulin regimen.


Long lasting recurrent familiar transient global amnesia after betablocker treatment withdrawal: case report.


The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.


Only one prior case has been reported in a patient receiving aggressive chemotherapy for a hematologic malignancy.


CASE: In reviewing the literature of intraperitoneal catheter complications, there is no other cited case of a peritoneal catheter erosion into intestine presenting as an enterovaginal fistula.


All her symptoms gradually subsided over the next few hours.


Magnetic resonance imaging revealed focal abnormalities, predominantly in the cortex, that on light and electron microscopic examination were demonstrated to be highly localized areas of neuronal loss, gliosis, and secondary Wallerian degeneration with paramyxovirus inclusions in the oligodendrocytes and surviving neurons.


He was initially managed as a suspected case of pulmonary embolism.


Although cortisol has a distinct circadian rhythm, patients with adrenal insufficiency usually receive diurnal hydrocortisone replacement therapy (HRT), disregarding possible consequences for sleep quality.


Epidural spinal lipomatosis with acute onset of paraplegia in an HIV-positive patient treated with corticosteroids and protease inhibitor: case report.


Reinstitution of the chemotherapeutic regimen once again led to an increase in INR.


The following is a case report of a 32-year-old man who experienced refractory bronchospasm upon emergence from general anesthesia.


All the patients recovered after an appropriate treatment for 83 days.


Clozapine has proven effective in reducing morbidity and suicidality in chronic non-remitting patients with schizophrenia.


OBJECTIVE: Pancreatic enzyme is essential in the treatment of cystic fibrosis (CF), but intolerance to it occasionally occurs.


Aspergillus terreus was isolated from her biliary fluid obtained at percutaneous transhepatic cholangiography.


Education of employees and physicians should result in the prevention of unnecessary tissue destruction and pain for those inadvertently exposed to hydrofluoric acid.


Rebound hyperglycemia was observed with both intermediate (neutral protamine hagedorn) and long-acting (protamine zinc iletin) insulins, and the range of insulin doses at which the disorder developed overlapped previously determined therapeutic doses for these insulins in the cat.


Myalgias were self-limited and lasted 4-10 days.


Patients with PS-1 AD may be at substantially increased risk of neuroleptic-induced EPS.


This rise was halved over the next 8 days.


This can occur with combinations such as non-steroidal anti-inflammatory drugs (NSAIDs), phenytoin (Dilantin), carbamazepine (Tegretol), and valproic acid (Depakene) or when the albumin level is low.


It is usually given in an outpatient setting.


After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.


Blastoschizomyces capitatus (BC), a filamentous fungus of genus Trichosporum, is as an important opportunistic pathogen in the compromised host.


It can be used to increase the intracellular concentration of chemotherapeutic agents in tumor cells (electrochemotherapy; ECT).


CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy.


Multiple sclerosis-like disease secondary to alpha interferon.


Staphylococcal pyomyositis in a patient with non-Hodgkin's lymphoma.


None of these patients were operated on.


Conversion to another immunosuppressant seems to be an appropriate procedure in this condition.


Retrospectively, bucillamine was believed to be the cause of the giant hypertrophy because of its structural similarity to D-penicillamine, which was the subject of an abundance of reports of mammary hyperplasia.


They improved rapidly and over 6 months were able to stop taking analgesics and return to normal activities.


Ichthyosiform erythrodermas and the 'half-baby syndrome' treated with an aromatic retinoid.


Recently, we have employed fibrin glue as a vehicle for the sustained release of ACNU (nimustine hydrochloride) by spray application following subtotal tumor removal in two patients with recurrent malignant gliomas.


Flutamide withdrawal syndrome is characterized by a decrease in prostate-specific antigen (PSA) after flutamide withdrawal in a subset of patients with progressing metastatic carcinoma of the prostate.


CONCLUSIONS: The 3 cases presented here illustrate the development of reproductive endocrine disorders after the initiation of valproate therapy in women with epilepsy.


To our knowledge, this is the first granulomatous reaction described after calcium hydroxylapatite injection.


Successful elective lumbar spine surgery was performed 4 days post-myocardial infarction during perioperative beta-blockade, after cardiology evaluation recommended surgery without further evaluation.


OBJECTIVE: To determine the prevalence of severe infections in patients with rheumatoid arthritis (RA) prescribed leflunomide in North Canterbury, New Zealand.


This case indicates that large and presumably organised thrombi may be treated with anticoagulant therapy.


CONCLUSIONS: Most cases of pseudoporphyria are drug-induced.


Furthermore in our patient we could show a strong lesional expression of MxA, a protein specifically induced by type I interferon.


It is suggested that, when drug induced pneumonitis is noted, careful screening of left ventricular function should be performed in order to diagnose myocardial fibrosis and subsequent cardiac failure.


Type 1 diabetes mellitus provoked by peginterferon alpha-2b plus ribavirin treatment for chronic hepatitis C.


Minimal evidence supports treatment with multiple antipsychotics, even when the agents have different mechanisms of action.


Abnormalities of the pupil and visual-evoked potential in quinine amblyopia.


Allergic and irritant contact dermatitis to calcipotriol.


Thrombotic microangiopathy in association with cytomegalovirus infection in a renal transplant patient: a new treatment strategy.


Five operations were performed in four patients: a nephrectomy for massive subcapsular hemorrhage with a prothrombin time that exceeded 100 seconds; arteriovenous graft complicated by post-operative bleeding associated with prolongation of the prothrombin time; elective femoral-popliteal bypass complicated by a prolonged prothrombin time, bleeding into the graft site, hypotension, and a subendocardial myocardial infarction; elective cholecystectomy complicated by a two unit bleed associated with a slightly prolonged prothrombin time, followed by elective femoral-popliteal bypass complicated by a fatal intercerebral bleed associated with a more than twice normal prothrombin time.


Fever and maculopapular rashes appeared at 10 days after phenytoin initiation, and then the drug was discontinued.


Two years after transplantation, nefazodone 50 mg twice/day orally was prescribed due to depression.


The patient was regularly taking a mixture of herbal products, used as a laxative, for a number of years, with no alteration of blood chemistry until 6 months before the present observation.


We report a case of a scleroderma-like reaction induced by long-term administration of UFT.


OBJECTIVE: To report teicoplanin-related neutropenia that developed after an episode of neutropenia induced by vancomycin therapy.


Herbal remedies generate more than 1.8 billion dollars in annual sales in the United States.


The infection was arrested but not cured.


He was successfully treated with albendazole and ivermectin, and immunosuppression was reduced.


DESIGN: We reviewed the medical records of four patients, who were seen by us between July 2000 and February 2004 for sudden onset of a central neurological syndrome within days of intrathecal MTX.


He was started on intravenous Zoledronic acid for reduction of bone pain and prevention of skeletal complication from multiple bone metastases.


The results of modeling studies have suggested and clinical investigations have confirmed a major pharmacokinetic advantage for exposure of the peritoneal cavity to certain chemotherapeutic agents compared with exposure of the systemic circulation when these drugs are delivered through the intraperitoneal route.


The ECG showed atrial fibrillation with a rapid ventricular rate.


The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.


A fatal outcome has been described in all reported cases of Fusarium infection occurring after bone marrow transplantation.


Symptoms and laboratory findings improved after zafirlukast was removed.


Two patients are described in whom subtle cognitive impairments are associated with therapeutic doses of amoxapine.


Six received intra-arterial alteplase and 1 underwent intracranial angioplasty; in a final patient, technical aspects prevented intra-arterial therapy.


Chemotherapy induced reversible posterior leukoencephalopathy syndrome.


This is the first reported case of BOOP associated with single-agent rituximab, and along with two other patients we describe, as well as two prior reports of BOOP in NHL patients receiving rituximab-based combinations, strengthens the possibility of a causal relationship.


A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.


Pancreatic carcinoma in a ten-year survivor of acute myeloblastic leukemia.


An antibiotic lock technique was created using a flush solution of vancomycin 1 mg/ml with 100 unit heparin/ml.


Propecia-associated bilateral cataract.


A case of presumed anaphylactic shock highlights early detection and review, rapid mobilization of the effector arm, and identification of implications for quality improvement.


The patient experienced muscle twitches, tremulousness, and anxiety on day 17 of foscarnet therapy.


Acute hepatic failure is a rare and potentially lethal complication of propylthiouracil (PTU) use for hyperthyroidism.


At three years progression free survival was 24% for the radiotherapy arm and 69% for the chemoradiotherapy group (P < 0.001), and three-year survival was 47% for the radiotherapy arm compared with 78% for the combined arm (P = 0.005).


We identified high numbers of PDCs in psoriatic skin lesions (up to 16% of the total dermal infiltrate) based on their coexpression of BDCA2 and CD123.


Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.


Preoperative chemotherapy for locally advanced breast carcinoma (stage IIIA,B) is increasingly utilized demonstrating a 70 to 95% objective response and 15 to 35% complete response.


Although lung specimens were lacking from these three patients, it is suggested that the pulmonary toxicity of CCNU may be dose-related.


No standard treatment has been established, but therapy must be prolonged, as relapses are common and can occur at the initial site or distant locations.


Massive subchorionic hematomas following thrombolytic therapy in pregnancy.


Symphysitis following transrectal biopsy of the prostate.


Progressive multifocal leukoencephalopathy after stem cell transplantation, unsuccessfully treated with cidofovir.


METHODS: We queried 35 rheumatologists at the Robert Breck Brigham Arthritis Center to determine if weight loss had occurred as an adverse event in patients treated with leflunomide between November 1998 and January 2000.


Ethambutol is commonly used for the treatment of tuberculous and atypical mycobacterial infection.


It is suggested that the fatal stroke may have resulted from arterial spasm caused by ergotamine overdosage and possibly complicated by thrombosis.


This report describes SIADH that developed in an elderly woman with single dermatomal herpes varicella zoster ophthalmicus without evidence of varicella zoster encephalitis or dissemination.


A pure osteogenic sarcoma of endometrial stromal origin developed in a 28-year-old woman with gonadal dysgenesis (Turner's syndrome) who had received estrogens for 18 years.


Malignant osteopetrosis generally begins in utero and often results in stillbirth.


All-trans-retinoic acid is an effective induction treatment for acute promyelocytic leukemia.


Her hearing gradually, then completely returned 2-3 months after the vincristine therapy was discontinued.


Investigations disclosed severe deficiency of all four vitamin K-dependent factors and a functional defect of platelets.


The cases raise a number of issues, including the need for clinicians to routinely ask patients about alternative medicine use, to learn more about these treatments, and to discuss these approaches objectively with patients.


Heparin was administered on the initial one and a half days.


DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult.


The neurological status of the patient has only slightly improved to the present.


Itraconazole can be administered as continuous dosing, 200 mg per day for 3 months, or in the form of pulse therapy, 200 mg twice a day for 1 week per month for 3 consecutive months.


A case of metoclopramide-induced oculogyric crisis in a 16-year-old girl with cystic fibrosis.


The exacerbation of a co-existing autoimmune disease is often a concern for physicians who use immunomodulating agents for the treatment of a concomitant process.


Both were suffering from acute and chronic GVHD and treated with heavy immunosuppression including steroids and cyclosporine.


The treatment continued with follow-ups every 15 days.


This patient's anemia resolved after discontinuation of the drug; he subsequently underwent an uncomplicated orthotopic heart transplant with no recurrence of anemia.


Theophylline plasma concentration should be determined whenever drugs affecting theophylline clearance are administered simultaneously.


This adverse effect has not been previously described for this agent.


Extensive necrosis of normal tissues was a prominent feature and it is suggested that the action of radiation in combination with cytostatic therapy on normal tissues need further investigation.


Bone scan showed multiple areas of increased uptake consistent with osteomalacia and microfractures.


A brief discussion of thyroid myopathy, thionamide drug reactions, and polymyositis is included.


Cardiovascular deterioration after seizures in tricyclic overdose has long been suspected.


PURPOSE: To describe retinal pigment epithelial tear following photodynamic therapy (PDT) for subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).


We describe a patient who developed intractable chronic vulval ulceration that we believe was related to immune reconstitution following treatment of HIV infection with highly active antiretroviral treatment (HAART).


We describe a case of catheter-associated aortoiliac thrombosis in a newborn who was successfully treated by urokinase infusion.


It is critical to differentiate this from other potential causes of hemorrhage, such as an acute bleed from an anastomotic false aneurysm which is a surgical emergency.


A 2-day-old newborn was treated with tolazoline for persistent pulmonary hypertension due to meconium aspiration syndrome.


Further control studies assessing the efficacy and safety of antiandrogen agents are recommended.


A patient with torsade de pointes risk factors (female sex, advanced age, extreme bradycardia and renal failure) who developed the condition on the fourth day of 400 mg/day of oral moxifloxacin treatment is presented.


In the seven patients, the mean plasma concentration of carbamazepine, but not of carbamazepine-10,11-epoxide, after clarithromycin coadministration was significantly (p < 0.01) higher than those at 1 and 4 weeks after its discontinuation.


Amiodarone-induced thyrotoxicosis associated with thyrotropin receptor antibody.


Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy.


Biperiden was transiently effective in the acute akathisia, while the more persistent akathisia was alleviated by mianserin.


Histopathologic examination revealed adenomyosis with cyst formation and an unusual thick capsule.