Epstein-Barr virus-associated lymphoproliferative disorder in a patient with rheumatoid arthritis on methotrexate and rofecoxib: idiosyncratic reaction or pharmacogenetics?


Surgical management of primary hyperhidrosis by upper dorsal sympathectomy is the treatment of choice for intractable hyperhidrosis, however, paradoxically it may be followed by troublesome compensatory hyperhidrosis in a significant number of patients.


Elevated muscle enzymes and findings on electromyography were consistent with myopathy.


By repeated testing other causes of diarrhea, e. g., infectious diarrhea including Clostridium difficile colitis were excluded.


Acute or chronic infections or inflammatory conditions can exacerbate anemia in patients on dialysis.


Two patients had elevated cone thresholds at least one year later.


Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.


We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.


We present a case of progressive disseminated aspergillosis that involved multiple sites in a bone marrow transplant recipient with severe, chronic graft-versus-host disease.


Nummular headache (NH) is a primary headache adopting the form of local pain in a circumscribed area of < 7 cm in diameter in the tuber parietale, albeit it may also be located in other areas of the head.


The pertinent literature on ergotism is reviewed, and it is emphasized that ergotism may develop in patients on therapeutic doses of the drug.


Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.


Her case was complicated by social and behavioral issues.


Therefore, other immunosuppressive agents have been used to replace glucocorticoids in the long-term treatment of autoimmune hepatitis, including azathioprine, a purine analogue.


Renal toxicities have been reported in less than one percent of the patients receiving ciprofloxacin therapy.


RESULTS: Pathologic gambling has emerged as one of the most prominent ICDs, although hypersexuality, compulsive shopping and other manifestations of obsessive-compulsive disorder may also dominate PD-related behavioral manifestations.


Previous studies have noted the difficulty in performing accurate injections into this area.


The pathogenesis appears to be multifactorial but involves rapidly rising vasoconstrictor tone in renal and systemic vascular beds.


6-Thioguanine is being increasingly used in the treatment of inflammatory bowel disease but has not been reported to cause liver injury in this context.


She developed SIADH 48 hours following chemotherapy.


We report a case of ibuprofen-induced meningitis in an otherwise healthy individual.


PATIENTS AND METHODS: Three patients with Parkinson's disease undergoing bilateral micro-recording guided surgery of the subthalamic nucleus (STN) are described; deep brain stimulation (DBS) was used in one case, and subthalamotomy in the other two.


Leucopenia and thrombocytopenia developed but were resolved by hydroxocobalamin infusion during administration.


Most breaches are not considered harmful.


Treatment has mainly been empirical.


METHODS: In an institutional practice setting, two women, aged 25 and 45, developed acute myopia after starting topiramate for epilepsy.


She was stabilized with prednisone, azathioprine, and tacrolimus.


The patient was ultimately treated with a nasal septal button with good symptom relief.


There were no immediate reactions on prick and intracutaneous testing with the commercial product used by the patient.


Although botulinum therapy effectively reduced the patient's refractory myofascial pain, signs and symptoms of SIS developed in association with the upper trapezii weakness after the third set of injections.


Long-term survival was studied in a group of 123 patients with malignant ventricular arrhythmia treated with antiarrhythmic drugs chosen primarily with noninvasive testing methods.


It is becoming increasingly evident the population at highest risk for sustaining a complication related to anticoagulation is that group presenting with traumatic brain injury.


A 27-year-old woman was admitted because of breathlessness, orthopnea, and hemoptysis.


The case also emphasizes the importance of T-cells in transplant associated immune cytopenias.


At least three other studies do not support these observations, but the tightly controlled conditions in these studies may not have simulated actual clinical practice.


Physicians and pharmacists should be aware of this possibility and must educate patients about the potentially serious adverse effects of such use.


Vancomycin-induced vasculitis.


The reflex was interrupted by blocking bilaterally the third division of trigeminal nerve.


The use of epidural local anaesthetics immediately after surgery delays the diagnosis of a postoperative neurological deficit.


These patients had robust responses to pramipexole augmentation of their treatment regimen.


We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.


This review is an in-depth report of the efficacy and safety of 1% lindane compared with the agents that have been preferred as alternative.


After therapy with parenteral amiodarone (2300 mg in 3 days) and other measures, signs of congestive heart failure disappeared; subsequently the patient developed jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy.


During the first treatment, dysarthria and ataxia were seen after completion of the patient's eighth and final dose of HDARAC.


Hemodialysis should be performed for rapid reversal of mannitol-induced ARF.


Aorto-oesophageal fistula complicating carcinoma of the oesophagus.


DISCUSSION: Two other case reports of nephrotic syndrome have been reported in the literature.


CASE REPORT: We describe here a case of a 60 year old female that experienced a relapse of symptomatic hyperlactatemia after being switched from stavudine to zidovudine and how the case was managed at the Infectious Diseases Institute, Kampala, Uganda.


Although retinoic acid is well tolerated by the majority of patients with this disease, a potentially fatal complication of this kind of treatment has been reported: "the retinoic acid syndrome".


The hope is that these cases will increase awareness of the potential use of capsaicin cream as an adjuvant analgesic in patients with residual limb pain.


Although psoralens are useful components of the psoralen ultraviolet A-range therapy that is mainly used for the treatment of vitiligo, psoriasis, and hypopigmented scars, they have a narrow margin of safety.


She had had her tongue painted with silver nitrate repeatedly 6 years ago for the treatment of oral ulcers.


OBJECTIVES: To describe the presentation and treatment of acute isoniazid (INH) neurotoxicity appearing at an inner-city municipal hospital.


METHODS: A 55-year-old man had diabetes with unilateral rubeosis and macular edema.


This resulted in a comatose state with depression of some brainstem reflexes.


The metabolic acidosis associated with the seizures may have caused hypotension by direct cardiotoxicity, an increase in bioavailability of tricyclic antidepressant because of changes in protein binding, an alteration of the effects of tricyclic antidepressant on cardiac membrane sodium channels, or a combination of these mechanisms.


The cutaneous manifestations of infection can include papules, plaques, nodules, vesicles, ulcers, ecchymosis, and, rarely, cellulitis.


We report a case of noncardiogenic pulmonary edema developed after therapeutic trial of EO as sclerosing agent for esophageal varix.


These cases were all fatal, and it is suggested that the use of clindamycin in leukaemic patients should be reserved for specific indications.


It must be distinguished from bilateral occipital lobe ischemia caused by vertebrobasilar system disease.


This eruption appears to be a distinct cutaneous toxicity of PLD.


We describe a patient with androgen-independent prostate cancer in whom PSA continued to decrease for a period of 15 months after flutamide withdrawal.


Development of persistent late onset asthma following treatment with captopril.


METHODS: Four cases of essential hypertension patients (1 male and 3 females) were observed through process of therapy with indapamide and laboratory investigations.


Cardiopulmonary arrest following intravenous phenytoin loading.


They are proof of a disturbed GABA metabolism in pyridoxine dependent seizures.


We report a case of CMV ventriculoencephalitis after unrelated double cord blood SCT with an alemtuzumab-containing preparative regimen for Philadelphia-positive acute lymphoblastic leukemia.


However, she developed new pulmonary symptoms and an enlarged cavitary lesion associated with the rapid formation of a fungal, ball-shaped shadow that was serially observed by radiological analysis.


Nineteen months after diagnosis, her mother gave birth to an HLA-compatible sibling, whose cord blood was cryopreserved.


Antimalarial psychosis revisited.


Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.


Bisphosphonates (eg, alendronate) are also indicated in the treatment of osteoporosis.


All patients were maintained on prophylactic topical ofloxacin 0.3% or polymyxin-B/trimethoprim, as well as prednisolone acetate 1% (in 2 cases, medroxyprogesterone 1%), at least twice daily.


The severity of this frequently irreversible and disabling condition warrants careful consideration in the use of long-term antipsychotic drug treatment in the young psychiatric outpatient population.


We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.


These findings suggest that disturbed serine-glycine metabolism may have a key role in certain schizophreniform psychotic syndromes.


Treatment with tacrine reversed the delirium, and a history of repeated benztropine use was obtained.


We report a case of Thrombotic Thrombocytopenic Purpura occurring as an allergic response to trimethoprim-sulfamethoxazole therapy (Bactrim, Septra) in a Jehovah's Witness patient.


Toxoplasma gondii retinochoroiditis after cardiac transplantation.


Pathophysiology of this disease is manifold and has been discussed as a posthemorrhagic complication as well as a neurological complication after operations with cardiopulmonary bypass.


Fatal cold medication intoxication in an infant.


All patients improved within 2 months after the drug was stopped.


DATA SOURCES: All relevant articles from January 1985 through February 1993 were identified, primarily through MEDLINE search and review of pertinent articles' bibliographies.


Treatment of pemphigus commonly entails both corticosteroids and steroid-sparing agents.


Intravenously administered itraconazole and rectally administered aminoglutethimide were used to suppress endogenous glucocorticoid synthesis.


The major adverse reactions of antithyroid drugs are hematologic; aplastic anemia (AA) is one of the rarest and most severe complications.


At this time, changing to another ACE inhibitor or additive therapy with nonsteroidal antiinflammatory drugs is not recommended.


The azathioprine dose was low (1 mg/kg) and pancytopenia occurred after 56 days therapy.


We present a case of accidental injection of tranexamic acid instead of bupivacaine during spinal anesthesia.


Lymphomatoid granulomatosis after immunosuppression for pemphigus.


Plasma levels of alprazolam, a substrate for the 3A4 isozyme, fell rapidly when nefazodone was discontinued, presumably because of renewed 3A4 isoenzyme activity.


The third case received ASCT with an unmanipulated autograft for relapsed angioimmunoblastic lymphoma.


A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.


We postulate individual hypersensitivity to FUdR or selective concentration of FUdR in brainstem structures to explain the toxicity in this case.


Upper gastrointestinal haemorrhage is a serious complication of aspirin and clopidogrel (dual) anti-platelet therapy with a high morbidity and mortality.


Although there is no rigorous evidence to support this management, private hyperbaric centers have been established throughout the United States and Canada.


Three nephrotic patients who had reduced renal function and active renal disease with progressive deterioration of renal function prior to the use of MP developed transient renal failure following an MP pulse therapy.


Cholesterol embolization treated with corticosteroids--two case reports.


One with stable chronic renal failure due to reflux nephropathy underwent a rapid deterioration of renal function which proved fatal.


The case of a 29-year-old man suffering from falciparum malaria disease who got a reversible hearing loss from quinine therapy is presented.


METHODS: Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described.


Mucin secretion was measured using an enzyme-linked lectin assay, and lung water was measured by wet/dry weight ratios.


The patients immune system and lung function slowly recovered during the same time period.


OBJECTIVE: To describe onset of syndrome of inappropriate antidiuretic hormone (SIADH) associated with vinorelbine therapy for advanced breast cancer.


About 45% of the total body amount can be extracted through a 3-h course of hemodialysis with resultant improvement in symptoms.


The diagnosis was confirmed by arteriography.


Crumley).


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


In addition, one must also question the effects that misplaced corticosteroids could have on the surrounding tissues.


Essential thrombocythemia is a clonal myeloproliferative disorder that causes thrombocytosis.


A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.


Delusional disorder, somatic type (DDST) is a rare psychiatric disorder and the treatment is mostly based on observations, due to the lack of well-organized studies.


A 25-year-old woman sought medical attention because of iliocaval manifestations of retroperitoneal fibrosis while she was taking methysergide.


CONCLUSION: Under certain circumstances topical brimonidine can cause paradoxical raised IOP necessitating vigilance in follow-up of patients on topical brimonidine.


The hazards of treating such patients with lithium are well known (Lazarus & Gilgor, 1979), but other drugs may also destabilize psoriasis.


We report a 53-year-old-man who developed rippling muscle disease (RMD) 2 months after starting simvastatin therapy for hypercholesterolemia.


We report for the first time the development of symptomatic methemoglobinemia after an acute ingestion of divalproex sodium (Depakote), resulting in serum concentrations 10 times greater than the therapeutic range.


Both the long-term affects of residual catheter within the central venous system and the need to remove the foreign body have yet to be addressed.


During the two weeks following the commencement of this treatment she occasionally complained of shortness of breath.


Four of 5 chronic hemo- or peritoneal dialysis patients also received multiple antibiotics.


Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.


The increasing use of this agent is expected, because of the increasing number of patients with inflammatory bowel disease.


Fatal venous thrombembolism complicating imatinib therapy in a patient with metastatic gastrointestinal stromal tumor.


OBJECTIVE: To report the safe use of fluorouracil in a patient with breast cancer who had allergic reactions to capecitabine.


The patient experienced two episodes of angioedema within a 10-hour period.


We describe a patient with acute myeloblastic leukemia (AML) who developed nephrotic syndrome after receiving several courses of chemotherapy, including macrophage-colony-stimulating factor (M-CSF).


The ocular toxicity of DCF, previously described as conjunctivitis, appears to be a keratitis of moderate severity which requires further study.


Thymic enlargement in a patient with juvenile idiopathic arthritis during etanercept therapy.


This case illustrates that the hemophagocytic syndrome associated with reactivation of EBV can occur as part of drug hypersensitivity reactions in RA patients taking sulfasalazine.


Intravenous levodopa 25 mg ameliorated his akathisia symptoms drastically.


With this case report, we bring to attention the association of the MVI shortage and WE.


Toxicity related to chloroquine treatment of resistant vivax malaria.


Several hours after the last dose, clinical manifestations recurred and ventilation was required.


An asthmatic patient with corticosteroid treatment for 45 years presented with slowly progressive limb muscle atrophy.


She required vasopressor therapy for intraoperative hypotension and developed severe headache immediately after administration.


Clinical and laboratory signs of liver injury resolved over the next few days, with a return to baseline levels of AST and ALT levels over the subsequent months.


Satisfactory initial results over the first few months of treatment were achieved when the new preparation was given to Transvaal patients known to have these disorders and hitherto treated in vain.


The combination of levodopa and peripheral dopadecarboxylase inhibitor is the most efficacious symptomatic treatment for Parkinson's disease.


Successful treatment of disseminated cutaneous phaeohyphomycosis in a dog.


The authors report 9 cases of dystonic reactions in patients with dementia following the initiation of antipsychotic medication.


Despite a hematologic response in all 3 patients, none of them achieved cytogenetic remission, and all progressed to blast crisis at 7 to 10 months of imatinib therapy.


In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.


Fatal liver failure following generalized tonic-clonic seizures.


Complications associated with primary and secondary perforation of the bladder following immediate instillations of epirubicin after transurethral resection of superficial urothelial tumours.


Amebic abscess of the spleen complicated by metronidazole-induced neurotoxicity: case report.


FK506 is an immunosuppressant that is thought to be less nephrotoxic than cyclosporine A.


The infant was fully breast-fed, and the neonatal lamotrigine serum concentration was 4.87 microg/mL at the time of admission.


However, given the clinically significant result to the interaction between tolazoline and cimetidine we report, the use of cimetidine in tolazoline induced upper gastrointestinal hemorrhage should deserve more attention.


This is the 1st case documenting intrathecal IgG synthesis and immune complex formation in this disorder.


Methylphenidate (Ritalin)-associated cataract and glaucoma.


A patient with acute changes suggesting acute hepatitis after parenteral amiodarone administration is described.


CLINICAL RELEVANCE: Pancreatic neoplasms are associated with a poor prognosis, regardless of treatment modality.


We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan.


Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.


The subject is a 66-year old woman, with a negative medical history of atopy, food and drug allergy, with arterial hypertension on a course of beta-blockers and with bladder carcinoma requiring surgery.


With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.


The corn oil-based soft gelatin capsule appears to be the safest formulation.


The extent of disease and subsequent reversal were documented using arteriographic examination.


We report a 50-year-old male patient with a 15-year history of psoriasis including mutilating psoriatic arthritis, in whom the withdrawal of cyclosporin A induced a generalised pustular exacerbation and a aggravation of the joint condition.


Treatment of total hyphema with relatively low-dose tissue plasminogen activator.


BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) is characterized by abnormalities in cerebral white matter and neurologic symptoms.


CONCLUSIONS: In any patient under clopidogrel (Plavix): Sanofi-Synthelabo, Bristol-Myers Squibb/Sanofi Pharmaceuticals) therapy and with a typical clinical presentation, SSEH should be suspected and quickly diagnosed, regardless of hemostatic status or the absence of other major risk factors.


When catheter disconnection, kink, or dislodgement is not visible on X-ray, radioisotopic control is a safe and reliable method for assessment.


Despite close monitoring of therapy, he experienced two episodes of unexpected and prolonged hypercalcemia.


STUDY DESIGN: Case reports are presented of three premature infants (mean gestational age 27 weeks) cared for in the intensive care nursery in whom clinically significant septal hypertrophy and left ventricular outflow tract obstruction developed during dexamethasone treatment for bronchopulmonary dysplasia.


Fatal radiation myelopathy after high-dose busulfan and melphalan chemotherapy and radiotherapy for Ewing's sarcoma: a review of the literature and implications for practice.


We suggest that sarcoidosis may develop in chronic hepatitis C patients during interferon alpha and/or ribavirin treatment, and diagnostic tests for this adverse effect should be performed during the follow-ups.


Tardive dyskinesia in an adolescent.


He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.


Treatment of tardive dyskinesia.


Patient examination 3 months after surgery revealed a large, central, full-thickness corneal infiltrate with multiple satellite lesions in the right eye.


RESULTS: Complete removal of the tumor was performed.


Correction after vitamin K administration suggested an organophosphate-related effect on vitamin K-dependent factor VII activity.


Ocular examinations revealed intraocular pressure (IOP) of 30 mmHg under medication, dense posterior subcapsular opacity of lens, pale disc with advanced cupping, and marked constriction of visual field.


We examined the effect of total parathyroidectomy (PTX) on renal anemia in 20 dialysis patients with secondary hyperparathyroidism.


Very low thiopurine methyltransferase activity represents the TPMTL/TPMTL genotype, and can be detected before therapy with azathioprine is started.


RESULTS: Eleven of the 32 patients (34.4%) developed retinopathy.


In the present study we describe two patients with different types of reaction patterns, one presenting as an allergic, the other as an irritant contact dermatitis.


This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP.


Cutaneous lichenoid eruptions can arise as a result of exogenous compound exposures.


We report a case of a 69-year-old male patient who came to our attention for macular edema in hemiretinal vein occlusion.


Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: four patient reports.


Glucocorticoid-induced osteoporosis (GIO) is an important problem that remains undertreated, even by rheumatologists.


The ECG pattern of BS has also been described in patients with myocardial abnormalities.


Amifostine-induced fever: case report and review of the literature.


Amiodarone treatment did not abolish the thyroid radioactive iodine uptake (RAIU), allowing for subsequent treatment with radioactive iodine.


Multiple periarticular abnormalities appearing on serial radionuclide bone scanning of the cancer patient, particularly when symmetric and in a distribution not suggestive of osseous metastatic disease, raise the possibility of multifocal osteonecrosis.


Two of 13 patients treated over the entire body suffered temporary bone marrow depression, indluding one with severe pancytopenia.


CASE REPORT: A 45-year-old woman had complicated Crohn's disease with multiple fistulae and only 1 m of residual small bowel.


The syndrome commonly presents with pruritus and increased muscle tone.


The patient was extubated 1 week later.


DESIGN: Observational case report.


Short cardiopulmonary resuscitation restored spontaneous circulation and the patient recovered completely.


Pressure-induced interface keratitis: a late complication following LASIK.


Children treated with thalidomide should undergo regular neurophysiologic studies in order to detect presymptomatic or progressive peripheral neuropathy.


This report describes a patient who developed pulmonary leukostasis in the absence of significant leukocytosis.


Necrotizing pancreatitis after transcatheter arterial chemoembolization for hepatocellular carcinoma.


Octreotide administration rapidly reversed hypoglycemia allowing patient stabilization and eventual discharge without any significant adverse events.


On reduction of the intrathecal baclofen dose, complete return to baseline sexual function was achieved for both subjects.


He had an extensive psychiatric history significant for schizophrenia and multiple past hospital admissions, starting at age 14 years.


In any patient with 'unexplained' muscle spasms or convulsions, strychnine poisoning should be included in the differential diagnosis and they should be asked about the use of herbal medicines.


Since, in some cases of eye burns, we have found corneal calcifications to be related to the initial calciferous caustic agents and to the use of phosphate-buffer-containing fluids, we have reviewed our files of clinical eye burns for the incidence and appearance of corneal calcification.


There were significant correlations between a change in Scr on the one hand and changes in BW and UV, Scr and serum albumin on the other.


Prehospital diagnosis was established by portable blood analyser and an early antidote with 4 MP treatment initiated in out-of-hospital setting.


The apparent low adverse effect profile of the new drug zafirlukast has made it an attractive choice in the treatment of asthma.


No cases of renal acidosis, and only one case of nephrogenic diabetes insipidus, has been previously reported as a complication of foscarnet treatment.


Case study: a modified topical treatment regimen for sodium warfarin-induced necrotizing fasciitis.


Drug-induced hepatotoxicity is an important cause of hepatocellular injury.


Fluorescein angiography was performed to confirm the presence of neovascularization.


On the eleventh day after the surgery, she experienced dyspnea and chest pain during standing and walking exercise.


Reteplase was administered with concomitant lepirudin.


CONCLUSION: Severe and sustained ocular hypertension may occur after intravitreal ranibizumab.


CASE: A 29-year-old primigravida with a history of four therapeutic amniocenteses for idiopathic polyhydramnios developed preterm labor at 30 and 5/7 weeks' gestation, rupture of membranes, and Candida albicans chorioamnionitis.


While successful treatment may require surgical intervention in some cases, others may respond to antibiotic therapy alone.


The reaction was aborted with diphenhydramine and dexamethasone.


Ocular hypertension occurred 1 month after the second ranibizumab injection in patients 1 and 3, and 1 month after the first ranibizumab in patient 2.


Mycophenolate mofetil substitution for cyclosporine-dependent myasthenia gravis and nephrotoxicity.


It is important to be aware of these rare complications, which are correlated with the prognosis.


DISCUSSION: The clinical presentation of ELP is nonspecific and ranges from the totally asymptomatic patient with incidental radiologic finding, like our patient, to the patient with acute or chronic symptoms attributable to pneumonia, pulmonary fibrosis, or cor pulmonale.


A massive digitoxin (DGTX) intoxication in a 36-year-old man (35 mg DGTX) was treated by prolonged and repeated i.v.-infusions of Fab fragments of anti-digitalis antibodies (FAB).


CASE: A malignant mixed mesodermal tumor was diagnosed in a 64-year-old woman with a bicornuate uterus while she was taking raloxifene for osteoporosis prevention.


In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.


The objective was to determine the effects of cholesterol-lowering agents on neurologic features and to develop a noninvasive method of monitoring clinical response.


DIAGNOSIS: Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma.


This case study discusses the new products and traditional treatment products used and presents results of irritant specificity testing and a series of photographs documenting resolution and healing.


Clinical manifestations including vomiting, diarrhoea and dyspnoea were identical in both cases.


Irinotecan therapy in a 12-year-old girl with recurrent brain stem glioma and without functional polymorphisms in UGT1A1 activity: case report.


Two cases of sacroiliitis due to P. avidum have been reported.


We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).


The noted increase in the theophylline level after zafirlukast administration is in contrast to the original reports by the manufacturer.


An infant who developed pancreatitis during meglumine antimoniate treatment for visceral leishmaniasis and who was successfully treated with a combination of allopurinol and ketoconazole is reported.


Fine-needle aspiration cytology (FNA) showed a pleomorphic adenocarcinoma in both the breast and axilla.


This etiology has to be considered in patients taking this drug who present with intraocular inflammation.


These may include 1) symptoms or history of mood spectrum disorder, 2) history of psychosis, 3) female sex, 4) family history of psychiatric disorder.


When the data of the 57 patients are evaluated, a reversible direct cytotoxic effect of ticlopidine on the pluripotent/bipotent hematopoietic progenitor stem cell is proposed.


Methylphenidate and dextroamphetamine-induced peripheral vasculopathy.


Coexistence of psoriasis and subacute cutaneous lupus erythematosus (SCLE) is unusual.


The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.


A 22-year-old female with renal failure secondary to focal segmental glomerulosclerosis underwent a deceased donor kidney transplant and presented 3 months later with pyelonephritis; the urine culture grew Kluyvera ascorbata.


We describe a case of subcutaneous metastasis along the needle track after percutaneous ethanol injection (PEI) for treatment of hepatocellular carcinoma.


We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.


Acne provoked by gold seems not to have been described elsewhere.


Two months after insertion and following a course of chemotherapy the lower end of the stent eroded the mucosa of the second part of the duodenum causing severe gastrointestinal hemorrhage which necessitated laparotomy and trimming of the stent.


Of particular interest in the present case report is the silent presentation and the absence of any pharmacological interference.


In all three patients, the diagnosis of AML was established by pathologists on the basis of bone marrow biopsy, aspirate, and peripheral smears.


Despite this improvement, the patient became resistant to the clozapine titration schedule due to complaints of sedation.


Acidic and neutral drugs were screened for by liquid-liquid extraction followed by high-performance liquid chromatography-diode-array detection.


We describe the case of a nonatopic 17-year-old girl with bronchial asthma and aspirin intolerance who developed a dramatic anaphylactic reaction to oral prednisone.


Erosion of psoriatic plaques: an early sign of methotrexate toxicity.


Management of immunocompromised patients with diffuse pulmonary infiltrates remains a common and stubbornly difficult problems.


Surgical evacuation of the laryngeal hematoma was not necessary.


Two months later she was bedridden.


Their plasma cell dyscrasias were evaluated with immunofixation electrophoresis of serum and urine specimens, quantitative serum lgs, and immunohistochemical staining of bone marrow biopsy specimens.


Microscopic examination of these colonies showed a high percentage of histiocytes identical to those seen in the patient's bone marrow.


Fibrinous anterior uveitis following laser in situ keratomileusis.


Associated thyreoiditis, myasthenia gravis, thymectomy, Chron's disease, and erythema nodosum: pathogenetic and clinical correlations, immune system involvement, and systemic infectious complications.


Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation.


DATA SOURCES: Case reports and review articles identified by MEDLINE.


Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia.


Hymenoptera sting can lead to an acute myocardial infarction by different pathogenetic mechanisms depending on the presence of preexistent coronary atherosclerosis, the development of shock or the therapeutic use of epinephrine.


Peritonitis due to Aspergillus and zygomycetes in patients undergoing peritoneal dialysis: report of 2 cases and review of the literature.


OBJECTIVE: To predict the effectiveness of alcohol neurolysis in the treatment of persistent pain caused by the entrapment of superior cluneal nerves.


Dexamethasone 4 mg orally twice daily was given around the time of chemotherapy administration to prevent the dermatitis associated with the drug.


RESULTS: Recurrences in both eyes were successfully treated with a combination of hexamidine and neomycin, and with polyhexamethylene biguanide respectively.


Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.


Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them.


BACKGROUND: In patients after treatment for malignant brain tumors, a clear distinction between tumor recurrence and radiation necrosis can be challenging.


Despite the complicated drug regimen with which the patient was treated, tobramycin was implicated by rechallenge with the drug once before its role was understood and again at an outside hospital.


Many patients who were on chronic TPN with MVI ceased to receive the MVI and were converted to an oral form of the multivitamin.


After two months of therapy, repeat echocardiography showed complete resolution of the thrombus.


An inverse correlation was found between plasma potassium and doses of phosphate (plasma potassium = -0.2 g phosphate + 3.9 r = -0.49; p < 0.05; N = 21).


Seven years later, after chemotherapy with chlorambucil, chronic myelogenous leukemia was diagnosed in addition to the chronic lymphocytic leukemia.


It has been reported that fluoroquinolone antimicrobials prolong the corrected QT interval but rarely cause torsade de pointes.


Bone marrow chromosomes were studied in 2 patients with polycythaemia vera (PV) at the time of diagnosis and several times subsequently during therapy with chlorambucil.


It is used worldwide not only as a cosmetic agent to stain the hair, skin and nails but also is applied to the body on lesions in the treatment of seborrheic dermatitis or fungal infections.


Clonazepam was given as needed, and the patient was discharged on February 1 with myoclonus that soon subsided.


Acetylsalicylic acid enhances both minor and major bleedings.


BACKGROUND: Delivery of tobramycin by inhalation to the lungs of patients with cystic fibrosis (CF) who are infected with Pseudomonas aeruginosa has been proven to be effective and safe.


The authors report a case of focal myocardial necrosis, presenting clinically as an acute myocardial infarction during the administration of the antineoplastic drug, amsacrine, in a patient without coronary artery disease.


METHOD: The case histories of two geriatric patients treated with bupropion for major depression are presented.


The shunt infection of the second patient was treated by replacement of the infected shunt system with a rifampin-impregnated device.


CONCLUSIONS: The authors suggest that conventional treatments be limited to a 2-month period, and that alcohol neurolysis be applied as soon as possible to prevent lengthy pain experiences.


An 8-year-old girl, who had been vaccinated with BCG without subsequent regional reactions, developed osteomyelitis in the left calcaneus 7 months later.


New onset of CD may be considered as an immune-mediated injury induced by etanercept.


Polymyositis is a rare complication of interferon alpha treatment as a result of immune-modulating role of the drug itself.


Two of these cases concerned relatively young, previously healthy patients and had fatal outcomes.


It is characterized by severe muscular rigidity, hyperthermia, and autonomic disturbances.


Although PWO is often easily managed with small doses of thrombolytic therapy (e.g., urokinase), it could result in a more serious complication, such as chemotherapy extravasation.


In conclusion, this case is instructive, because the symptoms which developed after a short period of corticosteroid inhalation suggested a type I allergy.


The dose of fluorouracil in the second cycle was increased to 400 mg/m(2)/d continuous infusion over 5 days.


Dihydropyrimidine dehydrogenase deficiency: a pharmacogenetic defect causing severe adverse reactions to 5-fluorouracil-based chemotherapy.


It is generally accepted that corticosteroid therapy may increase weight.


Diffuse cutaneous leishmaniasis (DCL) is a rare anergic variant of leishmanial infection with the characteristic presentation of numerous nonulcerating nodules with an abundant parasite load, lack of visceral involvement, negative reaction to the leishmanin skin test, and a chronic course with incomplete response to treatment and frequent relapses.


Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.


Death from inappropriate therapy for Lyme disease.


Except for the cellular membranes, each eye was without evidence of inflammation or cystoid macular edema.


Combination therapy for psoriasis with methotrexate and etretinate.


We report a case of hyponatremic seizures in a 7-year old boy with spina bifida following cystoscopy and suprapubic catheter placement.


METHODS: Between April 2002 and October 2003, we performed 24 liver transplants in 25 patients.


Addition of lithium carbonate resulted in a sustained remission with maintenance treatments.


A change in government program policies caused him to receive generic carbamazepine.


Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide.


During FAB-treatment total DGTX serum concentrations and renal DGTX clearance rose, indicating redistribution of drug from tissue to serum and urinary elimination of FAB-bound DGTX, respectively.


Patients with Crohn's disease may have reduced absorption in the small bowel due to loss of effective surface area secondary to chronic inflammation, ulcerative lesions, or resection.


The authors report a case of acute pancreatitis (AP) occurring in a patient under treatment with carbamazepine (CBZ) for post-traumatic petit mal epilepsy, and review the current literature of drug-induced AP.


On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.


Partial response to antipsychotic treatment: the patient with enduring symptoms.


The disease rapidly evolved into acute leukemia within 1 month after the onset of MDS, and the patient died 1 month later during induction chemotherapy.


In addition, a 31-year-old man with obsessive-compulsive disorder developed RBD soon after starting fluoxetine therapy, which persisted at PSG study 19 months after fluoxetine discontinuation.


Systemic lupus erythematosus and acute pancreatitis: a case series.


Responsibility for the provision and use of these inhalers in young people is discussed and suggestions made towards their greater control.


The patient and her parents underwent molecular analysis of the CYP2C19 gene, which may be implicated in the metabolism of this drug.


Circulating anticoagulant in the procainamide-induced lupus syndrome.


The possible mechanisms of this leukopenia are discussed.


After two months of mechanical ventilation, the patient was stabilized.


Changes in mood, personality, and social function were examined in a group of five Type 1 diabetic patients, aged 50 to 66 years, with duration of diabetes from 24 to 47 years.


In each of the three reported patients, alteration of eyelid appearance with deepening of the lid sulcus was evident as the result of topical bimatoprost therapy.


DGTX concentrations were determined after protein precipitation (release of FAB-bound and protein-bound DGTX) in unprocessed serum and urine samples, and after aliquots of these samples had been dialysed in vitro against DGTX-free buffer (elimination of DGTX not bound to FAB).


REVIEW SUMMARY: In this review, I summarize the newest approved medications for the treatment of PD, including the new dopamine agonists and catechol-O-methyl-transferase inhibitors.


Local dense accumulations of skin debris that became crusty were also observed.


Between July 1991 and December 1994 at Tsukuba Gakuen Hospital, we treated 19 consecutive men with advanced adenocarcinoma of the prostate (five at stage C, four at stage D1 and 10 at stage D2).


Pleuropulmonary changes during treatment of Parkinson's disease with a long-acting ergot derivative, cabergoline.


Psoriasis induced by interferon-alpha.


Therefore, intraperitoneal catheters should be removed if they are not being used.


TREATMENT: Emergency surgery is the treatment for this condition, but conditions such as the acute stage of a myocardial infarction or intraoperative bleeding difficulties due to iatrogenic coagulopathy, the degree of preoperative neurologic deficit, and the timing of surgery must be cautiously considered.


The patient died 7 years after the diagnosis of myeloma with extensive abdominal lymphoma.


Mefloquine-associated hypoglycaemia in a cachectic AIDS patient.


After hydrocortisone supplementation and intensive therapy the baby recovered completely.


Macular infarction after endophthalmitis treated with vitrectomy and intravitreal gentamicin.


Confusional paranoid psychosis after withdrawal from sympathomimetic amines: two case reports.


Radiographic studies suggest three possible explanations: (a) inadvertent thecal penetration during injection may have produced an atypical anesthetic block; (b) loculation of the injected fluid may have caused a transient compressive lesion; or (c) intrathecal injection may have produced an iatrogenic arachnoid cyst.


While rasburicase has the potential to provide a rapid reversal of TLS in this patient population, when TLS is complicated by pre-existing acute renal failure, additional interventions and alternative anti-tumor strategies may be necessary for a successful outcome.


Topical and local anesthetics are employed during minor invasive procedures to increase patient tolerance and to reduce the need for intravenous sedation.


This can potentially complicate further intervention should restenosis occur.


A young patient experienced marked sinus tachycardia while smoking marijuana and receiving therapeutic doses of nortriptyline.


Dipyrone is commonly found in the homes of families who are originally from areas where it is still lawfully marketed.


Both patients improved only when their antibiotic coverage was broadened to include Kluyvera.


We report a case of an infected subgaleal hematoma caused by an unusual micro-organism in a previously healthy 11-month-old girl.


The dosage of prednisolone was tapered, without a relapse, and then the corticosteroid therapy was stopped.


Postprandial plasma glucose levels were relatively improved by lispro insulin.


Immunosuppressive therapy was conducted with OKT-3 induction in the first patient because of the coexisting renal dysfunction and with a triple immunosuppressive regimen for both patients.


Endovascular or surgical interventions may be considered in patients with ergot toxicity for specific indications or those whose symptoms progress despite conservative management.


The case described here adds to the body of information about the possible causes of thyrotoxic ophthalmopathy.


The diagnosis was supported by the temporal course of renal deterioration during exposure to cefuroxime and improvement on its discontinuation; the pattern repeated with rechallenge.


Acarbose, an alpha-glucosidase inhibitor, has been used sporadically in adults after gastric surgery, but only once in children.


The neovascularization developed within 1 month after the laser anastomosis in all three cases.


CASE PRESENTATION: Three cases of Leishmania infantum leishmaniasis in corticosteroid (CS)-treated patients are reported: an isolated lingual leishmaniasis in a farmer treated with CS for asthma, a severe visceral leishmaniasis associated with cutaneous lesions in a woman with myasthenia gravis, and a visceral involvement after cutaneous leishmaniasis in a man receiving CS.


He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil.


A noninvasive method in the differential diagnosis of vecuronium-induced and magnesium-induced protracted neuromuscular block in a severely preeclamptic patient.


Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine.


She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.


Two patients had abnormal electroretinograms (ERGs).


(ClinicalTrials.gov number, NCT00126724.)


Six months later, a small amount of large to medium-sized VWFMs was still present, but at 7-8 months, the pattern of VWFMs became almost the same as that before infusion.


She had a history of schizophrenia and was treated with olanzapine 5 mg/day and lithium carbonate 300 mg 3 times/day.


With the negative viral serologies, the clinical picture was most consistent with an infectious mononucleosis-like syndrome produced by the minocycline ingestion.


Topical DMSO is a safe, inexpensive agent that appears to reduce the risk of anthracycline-induced tissue damage.


INTRODUCTION: Leflunomide is an immunomodulating agent with proven efficacy in rheumatoid arthritis.


RESULTS: The patient was treated with topical and oral antiviral agents and had complete recovery of the lesions in 10 days.


Multiple attempts to withdraw the medication resulted in relapse.


Although the relationship between antipsychotic medication, particularly second-generation antipsychotics (SGAs), and metabolic disturbance is increasingly accepted, there is an important, but little recognised, potential interaction between this and the other important serious adverse effect of neuroleptic malignant syndrome (NMS).


Namely, that recalcitrant psoriatic skin lesions may have good clearing on one biologic, such as efalizumab, and arthritic symptoms can be well-controlled with etanercept, leading patients to be on two different biologics concurrently to control symptoms.


BACKGROUND: The incidence of Mycobacterium avium complex (MAC) infection is increasing among patients with AIDS.


No side effects were observed.


Both had no past history of psychiatric or behavioural disorder.


There were no abnormal reactions to UVA.


Acute myocardial infarction during high-dose methylprednisolone therapy for Graves' ophthalmopathy.


OBJECTIVE: The purpose of this study was to determine whether desensitization to NPH insulin, as well as standard insulin desensitization, could control allergic symptoms in a patient allergic to both NPH and regular insulin.


A 17-year-old female patient who had been taking oral minocycline (50 mg twice daily) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis.


With this approach there is minimal surgical trauma and the IOL is retained.


Fatal varicella in steroid-dependent asthma.


Fatal ventricular fibrillation after treatment with digoxin in a 27-year-old man with mitral leaflet prolapse syndrome.


CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.


Our findings suggested that the antecedent use of high-dose corticosteroids is involved in precipitating normotensive renal crisis.


Acute syphilitic meningitis in a patient with systemic lupus erythematosus.


OBJECTIVES: A delayed stroke-like leukoencephalopathy has been observed in patients receiving methotrexate (MTX) for childhood leukemia.


This report describes the sudden appearance of mixed mania in three children with delusional depression soon after the commencement of tricyclic antidepressant therapy.


The skin lesions spread rapidly to most of the body, and ulcers of the ocular and oral mucosa appeared.


Both dogs had nonspecific respiratory signs and depression.


We present a case of hemolytic-uremic syndrome that developed during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin.


Spinal epidural lipomatosis (SEDL), an abnormal localized or tumor-like accumulation of fat in the epidural space, is an infrequent complication of chronic steroid usage and an uncommon cause of spinal cord compression.


Skin histology revealed peri-follicular, peri-bublar and supra-bublar lymphocyte infiltration.


Recent evidence has suggested several available methods to monitor free SDC during Fab therapy.


The cosmetic contact lens user should receive professional advice before accessing the lenses, and this must be communicated to the public.


The cycle of admissions was eventually broken by the intervention of a social worker, who provided structured non-medical support.


Thus, an immunological mechanism might be involved in the mechanism of pirmenol-induced QT prolongation and T wave inversion on the electrocardiogram.


Cutaneous rashes and eruptions can be caused by many medications, including carbamazepine.


Quantification of circulating varicella-zoster virus DNA for follow-up in a case of visceral varicella-zoster infection ameliorated with intravenous acyclovir.


Irritability is often a problem for patients with Post-Traumatic Stress Disorder (PTSD).


Intravenous phenytoin was urgently administered into the dorsum of the right hand.


Although rare in the adult population, it is associated even in the nonimmunocompromised host with increased morbidity and mortality.


Renal function was restored after withdrawal of enalapril and initiation of steroid therapy.


OBJECTIVE: Quetiapine is a recently introduced atypical antipsychotic.


We concluded that leflunomide is a new immunosuppressive agent with anti-CMV activity, which may be useful in the treatment of multiresistant CMV.


Is it quinine TTP/HUS or quinine TMA? ADAMTS13 levels and implications for therapy.


Rofecoxib and inflammatory bowel disease: clinical and pathologic observations.


We reviewed the cases of PnM in patients with DM treated with CsA.


In our patient, DIAN possibly was related to cefuroxime, but the patient did not experience associated allergic symptoms.


Case #3 was considered a mixed drug overdose.


When the dermatology service consulted the following day, the patient had developed an erythematous, edematous, tender plaque on his chest.


Decrease of TTKG was possibly the result of suppressed K+ secretion.


The association between heparin and priapism is often recognized; abnormal platelet aggregation could play a role in the pathogenesis of this side effect.


Serum antinuclear antibodies were present in high titer, and hypocomplementemia developed.


Penicillin-induced Jarisch-Herxheimer reaction.


The other woman had rheumatoid arthritis and developed acute tubular necrosis after treatment with gentamicin and cefoxitin.


Methotrexate (MTX) is a commonly used second line agent for RA, and there have been several recent reports of Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder in MTX-treated RA patients.


Priapism associated with olanzapine.


Copperhead envenomations in the Carolinas.


Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.


Most cardiac surgical patients have had previous exposure to heparin for diagnostic or therapeutic interventions and hence have an increased susceptibility to developing heparin-induced thrombocytopenia (HIT) postoperatively.


Seizures associated with fluoxetine therapy are uncommon.


The mean follow-up was 33 months (range, 26-48 months), and the mean treatment duration was 22.6 months (range, 13-32 months).


A case is reported of a subphrenic abscess 12 months post-laparoscopic cholecystectomy in a 72-year-old male with identification of Actinomyces meyeri and the oropharyngeal commensal Klebsiella ozaenae.


In four of 10 patients with PR, the tumor was not observable, although the tumor marker did not completely decline to the normal range.


Botulinum toxin is effective and safe for palatal tremor: a report of five cases and a review of the literature.


This proved to be extensive forearm deep venous thrombosis.


We compared the serum laboratory values and liver biopsy findings from group 1 with those from 10 patients with sporadic autoimmune hepatitis (group 2).


Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).


Colchicine-induced myopathy in a teenager with familial Mediterranean fever.


Because contact dermatitis due to a topical medication was suspected, patch testing was performed after disappearance of her eruption.


OBJECTIVE: To report a case of neuralgic amyotrophy associated with antibiotic therapy.


In the present case, the patient had been diagnosed with leprechaunism with mutation in the insulin receptor gene and had treatment with recombinant human insulin-like growth factor I (IGF-I) starting at the age of 1 year 7 months.


PURPOSE: Symptomatic visual field constriction thought to be associated with vigabatrin has been reported.


We report a case of P. avidum arthritis of the hip with severe sepsis that developed in a 78-year-old woman after intraarticular glucocorticoid treatment for hip osteoarthritis.


She experienced complete remission and has remained disease free since then, for more than 2 years.


The patient developed pulmonary aspergillosis with a rapidly fatal outcome despite recovery from neutropenia and improvement of the underlying malignancy.


The first cycle of her CHOP regimen was initiated (day 1) in our outpatient unit; she was then discharged home.


This short period of sinus rhythm was interrupted by sudden prolongation of the P-P interval starting the alternative rhythm.


Gabapentin's effects on hot flashes and hypothermia.


Transaminases promptly returned to normal after withdrawal of the laxative.


A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).


CONCLUSIONS: The procedure may be of value to counteract a recent trend of psychotropic polypharmacy in schizophrenia.


Possible mechanisms for these findings are discussed.


A helicoidal CT scan showed diffuse and severe interstitial pneumonitis, and lung biopsy confirmed accelerated usual interstitial pneumonia consistent with drug-induced toxicity.


The liver other than the nodules showed liver fibrosis associated with liver cell dysplasia and peliosis hepatis-like change.


Tuberculous peritonitis in patients undergoing continuous ambulatory peritoneal dialysis: case report and review.


Visual system side effects caused by parasympathetic dysfunction after botulinum toxin type B injections.


Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.


BACKGROUND: The calcitonin is an hormone produced by the thyroid gland C cells.


All patients received heparin for insertion, and in three patients, heparin was reversed with protamine.


Risperidone withdrawal-related respiratory dyskinesia: a case diagnosed by spirography and fibroscopy.


OBJECTIVE: We identified a group of patients with rheumatoid arthritis (RA) who were sensitive to both the beneficial and the side effects of intramuscular (im) gold treatment and whose disease was well controlled with doses of gold between 2 mg every 6 weeks and 5 mg weekly.


Tumor necrosis factor (TNF) alpha inhibitors are effective in the treatment of inflammatory rheumatic diseases.


Two days prior to admission to the CIU, he had been given 25 mg of fluphenazine decanoate injection intramuscularly in addition to his regular psychotropic regimen of thioridazine and haloperidol after reportedly making several verbal threats and displaying aggressive behavior toward the personnel at the group home where he resided.


The infection was resistant to both high-dose liposomal amphotericin B and voriconazole.


Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.


As more chemotherapy pumps are implanted, undoubtedly, new and unusual complications will occur.


He also had hypomagnesemia, hypophosphatemia, hypouricemia, proteinuria and glucosuria.


She passed a non-solid stone and continued indinavir treatment.


The mechanisms are not obvious, but it is likely that the rapid decrease of thyroid hormones in tissues may temporarily cause hypothyroid states, resulting in alterations in CK concentrations.


Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients.


Coagulopathy associated with the use of cephalosporin or moxalactam antibiotics in acute and chronic renal failure.


We report details of two liver transplant procedures in which post-reperfusion coagulopathy was reversed by administration of protamine sulphate.


Although these hormone therapies are generally considered benign, we describe 3 cases of acute cardiac rejection temporally associated with the use of these drugs in men who have undergone cardiac transplantation.


We report the first case of a tuberculous cutaneous lesion in a patient receiving the above treatment.


Nephrotic syndrome related to systemic lupus erythematosus after griseofulvin therapy.


We report a 61-year-old woman who suffered from an acute cerebral infarction during diagnostic cardiac catheterization for unstable angina, which manifested as sudden onset of global aphasia, right hemiplegia and gaze preponderance to the left side.


Within twelve hours, his clinical state was stabilized.


Primary intestinal aspergillosis after high-dose chemotherapy and autologous stem cell rescue.


ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.


Significant deteriorations were demonstrated in cognitive (p = 0.04) and social functions (p = 0.04), compared with assessment of pre-morbid function.


After the first oral dose of propranolol, syncope developed together with atrioventricular block.


The efficacy of corticosteroid therapy in the treatment of eosinophilia has not been clearly established.


The ampicillin rash occurring in cases of infectious mononucleosis is well documented.


While reviewing the literature, we found few less severe pulmonary injuries after intravenous use of paclitaxel, but none of these cases had a fatal outcome.


However, the history of prolonged veiling of the face by a cloth by the patient, perhaps contributing to the occurrence of lesions on face, is a point of dubious significance.


However, the complications both of the disease and its treatment, (e.g., acute oliguric renal failure, hip fracture) must be carefully monitored.


Off-label use should be discouraged.


Retrospective reanalysis of the radiation therapy technique, with emphasis on the doses received by the optic pathway structures, was performed.


We report a case of a child with neurodevelopmental delay with chronic constipation and a history of chronic mineral oil ingestion presenting as asymptomatic exogenous lipoid pneumonia (ELP).


Risk factors for Zygomycosis were prolonged neutropenia, corticosteroids, and steroid induced diabetes mellitus.


Only one case of a generalized maculopapular rash with enoxaparin has been reported in Europe.


More flexible diagnostic criteria than currently mandated by the the Diagnostic and Statistical Manual of Mental Disorders, Fourth Revision, may be warranted.


CONCLUSIONS: To avoid and protect themselves against potential abandonment allegations when termination of the physician-patient relationship is warranted, physicians are advised to consider following the outlined procedures.


A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.


A common pathogenesis to link these agents to fibrosis remains uncertain.


One patient had known atherosclerotic heart disease, and 2 patients had risk factors for coronary artery disease.


These cases are discussed in the context of evidence that lithium may be useful in other patients with disorders of impulse control.


Resolution of systemic hypertension and partial return of right renal function followed rapid thrombus dissolution.


A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate.


Chemotherapy usually consisted of alkylating agents often given in high dose and for long durations.


Our case illustrates an unusual presenting symptom of hemoptysis and the need to identify patients who can be at risk of developing this rare condition.


Because OK-432 (penicillin-treated and heat-treated lyophilized powder by a substrain of Streptococcus pyogenes A) was expected to be effective for immunosuppression, we tried its topical injection.


A right hemicolectomy was performed with relief of symptoms.


Accidental ingestion (five episodes) and suicidal attempts (three episodes) accounted for these visits.


Pityriasis lichenoides-like eruption occurring during therapy for myelogenous leukemia.


According to the Naranjo adverse drug reaction probability scale, the development of KS in this case was probably associated with the imatinib treatment (score, 5-8).


Cerivastatin is catabolized by cytochrome P450, 3A4 and 2C8 to M-1, and by 2C8 to M-23.


Chlorambucil has only rarely been implicated in this complication.


Immunoblastic sarcoma is also seen in immunosuppressed patients, and the role of the immunoblast in both of these disorders indicates that they may be related.


We sought to assess the safety and feasibility of this approach.


Catheter fracture and cardiac migration: a rare complication of totally implantable venous devices.


He was diagnosed in the early post transplant period after anti-rejection therapy.


Raised intraocular pressure and glaucoma have rarely been associated with use of periorbital corticosteroids for dermatological conditions such as blepharitis and eczema.


Beginning ductopenia was present in two, suggesting that itraconazole might be responsible for the occurrence of prolonged drug-induced cholangiopathy.


RESULTS: DWI of all patients revealed well-demarcated hyperintense lesions within the subcortical white matter corresponding to areas of restricted proton diffusion on ADC maps.


Although monoclonal integration of human T lymphotropic virus type I (HTLV-I) proviral DNA was detected in the peripheral blood lymphocytes at ATL diagnosis, bone marrow cells at t-MDS diagnosis did not show monoclonal integration of HTLV-I.


A 53-year-old female who developed myelodysplastic syndrome (MDS) after chemotherapy for adult T-cell leukaemia (ATL) is described.


A 45-year-old woman and a 49-year-old man, both with a history of rheumatoid arthritis, were treated with etanercept and infliximab, respectively.


Clinical and microbiological data were collected prospectively from 704 patients who underwent bone marrow transplantation (BMT) during an 11-year period (1991-2001), and the first two cases of Campylobacter infection occurring in BMT recipients in the pre-engraftment period were identified.


We present a 46-year-old African-American man with AIDS who was admitted on two different occasions within three weeks for signs and symptoms of meningitis after using trimethoprim/sulfamethoxazole (TMP/SMX).


Parents of children taking high doses of inhaled corticosteroids should be alerted to the clinical features of adrenal insufficiency.


Before the infusion he was pretreated with ranitidine, cetirizine, hydroxyzine, montelukast, and prednisone.


According to the literature, chlorambucil central nervous toxicity is found almost exclusively in childhood nephrotic syndrome.


Percutaneous coronary interventions of ostial right coronary artery stenoses are associated with increased procedural complications as well as with higher rates of angiographic and clinical restenosis.


Kidney biopsy demonstrated membranous glomerulonephritis.


This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis.


We present the case of 48-year-old woman suffering from migraine with aura (MA) since menarche.


Measurements of protected isolation and selective intestinal decontamination were taken.


Considering the increasing use of TMZ, which is regarded as a drug with moderate toxicity, careful follow-up with routine blood testing is vital.


A repeat provocation test, under antihistaminic cover , failed to produce similar response.


Severe autoimmune myasthenia gravis is difficult to manage and may require immunosuppression with cyclosporine.


All isolates were believed to be clinically significant.


They also suggest that liver enzymes should be monitored during treatment with riluzole.


Nocardia is a serious opportunistic infection in renal transplant recipients and nocardial brain abscess in these patients has a high mortality.


DESIGN: A small noncomparative interventional case series.


Complete recovery of the headache symptoms occurred only after OXC was discontinued.


Symptoms disappeared rapidly following cessation of emepromium bromide therapy.


Gabapentin-induced mood changes with hypomanic features in adults.


This case illustrates the potential diversity of clinical lesions in a single patient with NEH, and its response to systemically administered corticosteroids.


Clozapine treatment of borderline patients: a preliminary study.


Fatal pulmonary fibrosis induced by paclitaxel: a case report and review of the literature.


Using anti-CD79a as a B-cell marker is mandatory to overcome the difficulties in identifying these tumors.


CONCLUSIONS: The tumor in the reported case may have enlarged in response to orally ingested sex steroid pills.


Neurological manifestations in patient 1 could be due to hypertension secondary to IVPMP, while the pathogenesis of such manifestations remained difficult to clarify in patient 2.


The second author concurs with use of Silvadene cream and would avoid any pressure on the area (Dr.


It seems that being aware of the undesirable affects of tamoxifen treatment during the chemotherapy and post-chemotherapy period is very important.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


Neuroleptic malignant syndrome due to risperidone treatment in a child with Joubert syndrome.


Albuterol-induced hypokalemia and its potential cardiac toxicity are discussed briefly.


We, therefore, recommend a trial of HU for thalassemia intermedia patients in whom chronic transfusion therapy is being contemplated.


Thalidomide neuropathy is often associated with proximal weakness and may progress even after discontinuation of treatment, in the phenomenon of 'coasting'.


The patient's arthritis flared after the second infusion of infliximab, which was discontinued.


This resulted in clearance of the virus from the AF and the delivery of a healthy newborn girl, free of CMV disease.


Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported.


Severe hypernatraemia associated with growth hormone replacement therapy in a patient with septo-optic dysplasia.


A proposed management scheme is detailed, including intravenously-administered propranolol as the preferred first-line antiarrhythmic agent.


Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia.


Whether the simultaneous administration of ciprofloxacin or tazobactam/piperacillin increases the risk of thrombocytosis is unknown.


He was well and his serum creatinine was 1.0 mg/dl at 22 years of age.


Naloxone administration reversed the symptoms.


This phenomenon mimics the extrarenal production of 1,25-dihydroxyvitamin D by activated alveolar macrophages in granulomatous diseases with hypercalcemia.


Opioid drugs cause bile duct obstruction during hepatobiliary scans.


The patient was successfully treated with early surgery and combination antifungal therapy.


His VPA concentration at admission was 238 micromol/L, a 48% decrease.


A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.


This paper reports an autopsy case of a 78-year-old male with multiple nodules in the liver developed after long-termed administration of phosphate diethylstilbestrol (PDES) for prostatic cancer.


It can mimic other diseases because of its nonspecific clinical presentation and radiographic signs.


The inherited activity of the enzyme thiopurine methyltransferase has been recently recognised as a major factor in the susceptibility to myelosuppression.


Discontinuation of chemotherapy, desensitization protocols and steroid premedication can be avoided.


We conclude that these agents should be used with great care in patients in whom atherosclerotic vascular disease is likely.


Diclofenac-associated hepatitis.


These results suggest that clozapine may be an effective antipsychotic agent for this subset of BPD patients.


Neuroleptic malignant syndrome is an uncommon and potentially fatal idiosynchratic reaction of antipsychotic drugs, in which the clinical scenario encompass muscular rigidity, hyperthermia, autonomic dysfunction, altered consciousness, high creatinine phosphokinase levels, and leukocytosis.


RESULTS: A total of 178 cases were identified.


Renal failure necessitated 5 hemodialysis sessions.


Here, we report a case of acute liver dysfunction complicated with uncontrollable glycemia due to insulin antibody.


Concern usually arises when a medication is added to a continuing regimen, though discontinuation of a medication can also have an impact.


Positive immunohistochemistry staining of a biopsy specimen for cytomegalovirus suggested a viral etiology; however, lesions persisted despite antiviral therapy, and immunohistochemistry was negative on follow-up biopsy.


PVT was diagnosed on colour Doppler ultrasonography (US).


The changes were progressive regardless of discontinuation of cyclophosphamide and led to severe restrictive ventilatory defect.


An Asian multiparous woman weighing 47 kg, who suffered from a rare myopathy, congenital fibre type disproportion, was given morphine 10 mg intramuscularly for labour analgesia.


Imatinib is a selective tyrosine kinase inhibitor which acts on breakpoint cluster region-Abelson fusion gene (BCR-ABL) positive leukemia including all phases of chronic myeloid leukemia and acute lymphoblastic leukemia.


In all patients, the administration of cisplatin instead of carboplatin was well tolerated without the need of premedication.


However, the characteristic ultrasound appearance of both pathologies facilitates determination of the final diagnosis and further treatment.


Proconvulsive tendency of imipenem/cilastatin is one of its well-known side effects.


Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.


This report describes a case of neuroleptic malignant syndrome due to risperidone in a child with Joubert syndrome.


This toxic effect may be added to the list of potential adverse events occurring during ddI therapy.


A case of prolonged suxamethonium apnoea successfully terminated by the infusion of a commercial preparation of serumcholinesterase is reported.


In the absence of clinical or morphologic differences, a recent ingestion of minocycline should be excluded before the diagnosis of sporadic autoimmune hepatitis is established.


We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).


He began smoking again within 48 hours.


In the presented case fluvoxamine-induced akathisia in an OCD patient was partially resistant to the anticholinergic agent biperiden, and was successfully treated with the 5-HT2A/5-HT2C antagonist mianserin.


Complete remission of BOOP was achieved by long-term treatment with low-dose methotrexate (5-20 mg/week, i.v.).


CK and/or alanine aminotransferase and aspartate aminotransferase were increased 5-24 times above the normal range in four of these patients, and the muscle biopsy showed focal RML in all five.


RESULTS: Despite high pretreatment values of serum alanine aminotransferase (ALT; peak value of 901 IU/L) and HCV-RNA (2.3 x 10(6) copies/ml), the combination therapy with IFN and ribavirin produced a rapid normalization of the serum ALT values, accompanied by the clearance of serum HCV-RNA.


Although the two local anesthetics usually do not cause methemoglobinemia, we suspect that the displacement of lidocaine from protein binding by bupivacaine, in combination with metabolic acidosis and treatment with other oxidants, was the reason for the development of methemoglobinemia.


In addition, the patient tolerated other neuroleptics that were started in the hospital after the suspected NMS episode.


In these patients, the action of tricyclics can be conceptualized as accelerating rather than counteracting the natural, cyclic course of the illness in all of its phases.


Testing proved a severe type IV contact allergy restricted to budesonide (group B), without cross-reactions to major corticosteroids of other groups.


F VIII concentrate was given concomitantly (50 IU/kg bw twice daily) during the initial phase of treatment.


Alkylating agents have a well established role in the treatment of malignant disease, with well documented side effects.


Dapsone, a potent antiparasitic and anti-inflammatory compound, is mainly used in the treatment of leprosy and a variety of blistering skin diseases.


On the first day of the schedule, moderate high doses of Methotrexate, Etoposide and Cyclophosphamide were administered.


The subjects received the urinary sediment test before and during the study for screening urinary tract infection and the study was discontinued when urinary tract infection was found.


CASE SUMMARY: A 22-year-old male was admitted after a motor vehicle crash.


Cushing's syndrome caused by unsupervised use of ocular glucocorticoids.


Three patients (3 eyes) representing unresolved total hyphema for more than 5 days and uncontrolled high intraocular pressure received intracameral injections of 10 microgram of recombinant tPA.


An ICD implantation was selected for the therapy since ventricular fibrillation was induced.


PURPOSE: To report our experience with late vitritis associated with keratoprosthesis (KPro).


Acute neuritis can lead to permanent nerve damage and necessitate prompt treatment with prednisone and/or clofazamine.


BACKGROUND: We report six cases of psychosis in patients with akinetic-rigid syndromes who were treated with risperidone.


Adverse reactions reported during cimetidine therapy were generally mild to moderate in severity and required discontinuance of therapy in only one patient.


This unusual cutaneous sign may be the first sign of methotrexate toxicity.


Chromoblastomycosis, or chromomycosis, is a chronic fungal infection of the skin and subcutaneous tissues caused by a species of dematiaceous fungi.


Due to the escalating rates of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infection, trimethoprim-sulfamethoxazole (TMP-SMX) is being used increasingly in the pediatric population for skin and soft tissue infections.


This had been given systemically during the patient's last week of life.


Fludarabine phosphate is currently proposed for the treatment of refractory chronic lymphocytic leukemia (CLL).


Case report: lack of control of diabetes and weight gain in a patient on initiation and rechallenge of therapy with olanzapine.


The increasing administration of protocol chemotherapy by practitioners in the community, who may not be especially familiar with the particular agents in a given regimen, suggests such errors may become more common.


We present a depressive patient who developed mild parkinsonian signs and camptocormia after the introduction of olanzapine.


Comeoscleral perforation after pterygium excision and intraoperative mitomycin C.


We report a case of MMC-related hemolytic uremic syndrome, and discuss the etiologic parameters, clinical aspects, prognosis and treatment modalities of this severe syndrome.


A case is described where a woman with major toxicity and high serum levels was managed without recourse to invasive modalities such as cardiopulmonary bypass or extracorporeal therapies.


In summary, adenosine should be recognized as a potentially dangerous intervention in patients with atrial flutter.


This patient adds to the growing literature of a second malignancy occurring after prolonged successful chemotherapy of a primary neoplasm.


It can be caused by a variety of factors, including repeated steroid injections, chronic tenosynovitis, and decreased blood supply to the tendon.


At 1 month the rabbits were killed and the eyes examined by light microscopy.


After an interval of 3 months, he presented a complex pattern of nail hyperpigmentation, from combined dense horizontal and longitudinal streaks in some nails to diffuse black discoloration in others (Figure).


Intravesical chemotherapy may be associated with a risk of secondary malignancy.


E. avium bacteremias were polymicrobial in seven cases; in six cases, the coisolates were gastrointestinal organisms.


Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.


General aneurysmatosis due to cheese consumption: complications of an endocarditis caused by Lactococcus cremoris.


The risk of massive cerebrospinal fluid overdrainage after repetitive manual pumping of the V-P shunt reservoir, which can contribute to the formation of a cerebellar hemorrhage, warrants special attention and hydrocephalic patients and their caregivers should be informed and educated about this potential complication.


DESIGN: interventional case report.


Reasonable precautions (regular but briefer and less vigorous brushing of her teeth) combined with a moderate dose of carbamazepine effectively prevented seizure recurrence.


Therefore, parenteral amiodarone was implicated as the cause of acute hepatitis in this patient.


Reversible cholestasis with bile duct injury following azathioprine therapy.


CONCLUSION: Intraperitoneal catheters have a morbidity that persists after nonuse.


Gemcitabine was not resumed.


It also draws attention to the fact that drug-induced OGC may be a multifaceted disorder with disturbances of movement, thought, behavior, and emotion, reminiscent of the OGC described in association with epidemic encephalitis lethargica.


Delirium in the intensive care unit: are we helping the patient?


A table of all the cases reported in the literature is compiled.


Propionibacterium avidum is a Gram-positive, nonsporulating, facultative anaerobe that has a low level of virulence and is rarely pathogenic.


We suggest that the previous classification of nitrofurantoin induced lung injury into "acute" and "chronic" injury is an oversimplification in view of the wide variety of pathological entities that have subsequently emerged.


Visual acuity improved and IOP was within normal limits in both eyes postoperatively.


Nonsteroidal antiinflammatory agents (NSAIDs), especially naproxen and other propionic acid derivatives, appear to be the most common offenders.


Direct immunofluorescence findings were consistent with either cicatricial pemphigoid or linear IgA dermatosis, since both IgG and IgA linear deposits were found at the basal membrane zone.


Renal damage associated with long term use of lithium carbonate.


A case is presented in which, during regular endodontic treatment, uncontrollable bleeding occurred, suggestive of a generalized bleeding disorder.


A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.


In this respect, tricyclics are analogous to several other drugs that are capable of modulating the frequency of oscillatory biological processes.


The importance of the need to avoid misdiagnosing heat stroke as neuroleptic malignant syndrome is reviewed.


There is evidence to suggest that perfusion treatment is even superior to amputation as regards survival; if so an immunological mechanism might be responsible for this effect.


Estramustine is a combination of estradiol and nitrogen mustard, and alone has shown objective responses in advanced prostatic cancer.


We present a case of a patient with two preexisting Silastic syringosubarachnoid shunt catheters who developed Enterobacter meningitis.


Intravenous methotrexate is an effective adjunct to steroid therapy in the treatment of steroid-resistant or life-threatening dermatomyositis-polyositis or dermatomyositis-polymyositis complicated by severe steroid-related effects.


We report the first case, to our knowledge, of rituximab-related autoimmune hemolytic anemia.


These observations suggest that E. avium bacteremia most often originated from a gastrointestinal tract source.


However, the patient survived thanks to early diagnosis confirmed by polymerase chain reaction on blood and by serological techniques, and early treatment.


Sotalol-induced bradycardia reversed by glucagon.


Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them.


The resulting increased turnover of heme might then result in overproduction of porphyrin precursors, resulting in the clinical syndrome.


Bilateral acute angle-closure glaucoma after bronchodilator therapy.


Liver dysfunction in ovarian hyperstimulation syndrome.


Aberrancies in T3 suppression testing in graves disease occur.


Like other myeloproliferative diseases, ET is associated with an increased risk of development of acute leukemia (AL).


F VIII plasma activity ranged between 47 and 88%.


His serum potassium level normalized despite continuation of the prednisone therapy.


Disturbance of GABA metabolism in pyridoxine-dependent seizures.


Anabolic-androgenic steroids have been reported to have anticoagulatory and profibrinolytic effects in patients with protein C deficiency.


A case of phenytoin-induced hepatitis with mononucleosis is reported, and syndromes associated with phenytoin hypersensitivity reactions are discussed.


Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C--a case report and review of the literature.


Hysterectomy revealed benign endometrial megapolyps with marked stromal decidualization and edema.


A 58-yr-old male patient with essential thrombocythaemia (ET) developed chronic myeloid leukaemia (CML) after continuous uneventful treatment with hydroxyurea for 18 yr.


The clinical course of a 69-year-old male with acute myelogenous leukemia is described who, while extremely leukopenic (less than 100 neutrophils/microliter) from chemotherapy, developed a cavitating pneumonia due to a gram-positive coccus, Micrococcus luteus.


Dental and craniofacial characteristics in a patient with leprechaunism treated with insulin-like growth factor-I.


Photo-onycholysis caused by olanzapine and aripiprazole.


Oral intake and acarbose were withheld and the ileus spontaneously resolved after 2 days.


Antitumor activity was observed in four patients.


A 35-year-old woman was treated with intraventricular methotrexate (MTX) with a total dose of 70 mg followed by cytosine arabinoside (Ara-C) with a total dose of 80 mg for meningeal metastasis of breast carcinoma.


Close patient monitoring is advisable in these types of patients.


Nephrotoxicity of selective COX-2 inhibitors.


Epithelioid angiosarcoma of the lung: a rare late complication of Lucite plombage.


BACKGROUND: We report our experience with two patients with adult onset of chickenpox in the setting of longstanding steroid therapy for nephrotic syndrome.


Vigabatrin (VGB) is an important treatment option for infantile spasms.


An anesthesia provider must immediately initiate treatment if bronchospasm is suspected in order to avoid negative sequelae.


Panic anxiety after abrupt discontinuation of mianserin.


Multiple cultures failed to reveal sepsis and a urinary pH of 4.85 together with tests of renal acidification, excluded renal tubular acidosis.


A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression.


A reduction in immunosuppression and the addition of acyclovir did not result in improvement.


Depressive symptoms disappeared after interferon therapy was stopped.


Bevacizumab is a recently developed monoclonal antibody against vascular endothelial growth factor receptor used to inhibit angiogenesis.


Intravenous administration of 90 mg commercial serumcholinesterase, the equivalent to 1000 ml fresh human plasma, restored twitch and tetanic responses and the patient could lift his head 15 min after the beginning of the enzyme injection.


Prolonged prostate-specific antigen response in flutamide withdrawal syndrome despite disease progression.


OBJECTIVE: Clozapine causes few extrapyramidal symptoms and is recommended as a treatment drug for severe tardive dyskinesia (TD).


The typical fluoxetine-induced symptoms of restlessness, constant pacing, purposeless movements of the feet and legs, and marked anxiety were indistinguishable from those of neuroleptic-induced akathisia.


Possible etiologic factors are traumatic osseous lesions and transport of rectal bacteria to the periosseous region.


Vascular catheters are associated with complications such as infection, thrombosis and stenosis.


Delusional parasitosis associated with phenelzine.


Reperfusion of the transplanted heart was performed retrogradely through the coronary sinus utilizing leukocyte-depleted blood with a gradual increase in temperature.


In this case, developmental and functional disturbances of the primary and permanent dentition are seen.


Methylene blue (MB) may be used in the treatment of this encephalopathy.


Three patients developed proteinuria following gold therapy for rheumatoid arthritis.


The reaction is thought to be due to the effects of treponema breakdown products, and it should not be confused with an allergic reaction to the antibiotic employed.


The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.


Phenylpropanolamine (PPA) recently has been publicly implicated as a cause of stroke and other neurologic events.


He was diagnosed with acute pleuropericarditis by blood tests, electrocardiogram, chest X-ray, and echocardiogram.


On investigation no new change was noticed than previous evaluation.


PURPOSE: To report the detection of cytomegalovirus (CMV) DNA in the cornea of a CMV endotheliitis patient after penetrating keratoplasty (PKP).


CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.


Several drugs (e.g., penicillin, probenecid) can alter the elimination of methotrexate.


Two unusual pathological reactions to nitrofurantoin: case reports.


Drug provocation test in patient with antituberculosis drug allergy.


Hyperthyroidism complicating asthma treatment.


Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia.


It has activity against both the positive and negative symptoms of schizophrenia, which has made it an alternative to traditional antipsychotic medications such as haloperidol.


We report a case of a 54-year-old female who ingested approximately 100 propoxyphene hydrochloride tablets in a suicide attempt.


Because of tumor progression, therapy was discontinued after a cumulative dose of adriamycin of 120 mg/m2.


A case is reported of a 40 year old woman treated with intraventricular IL-2 for leptomeningeal disease who developed progressive cognitive dysfunction.


METHODS: Tissue obtained during vitrectomy was cultured and examined by light and electron microscopy.


Symptomatic hypocalcaemia and renal impairment associated with bisphosphonate treatment in patients with multiple myeloma.


Unique behavioral change with cinepazide in parkinsonism.


The interaction of radiotherapy with oxaliplatin needs to be further studied.


CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.


Because the shortage of MVI is expected to be a long-term, there are likely to be more cases of WE in the pediatric population of TPN-dependent children.


Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale.


DISCUSSION: A comprehensive literature search of Medline using WebMd and MDConsult, was conducted to cross reference known side effects of topical prostaglandin analog treatment.


The cause of death was determined to be multiple drug intoxication.


Following the diagnosis of colon cancer (Duke's classification D), a chemotherapy regimen of 5-FU and levamisole was started.


This article presents a case of an asthmatic with dental manifestations and reviews the possible causes and management of the same.


Intermittent or interrupted therapy appears to be a significant risk factor for the development of this complication.


The patient's dental development and pharmacological history suggest prednisone as the offending agent.


This is particularly the case for children, who often exhibit resistance to intramuscular or rectal administration of drugs.


The case is discussed and the pertinent literature reviewed.


Pharmacologic doses of recombinant human erythropoietin in the treatment of myelodysplastic syndromes.


We describe a case of bullous pemphigoid (BP) in a patient with chronic renal failure maintained on hemodialysis.


The results of these studies suggest that immune complex deposition does not involve gold and sulfur acting as haptens.


We conclude that vincristine and actinomycin D were the cause of this rare from of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.


RT can result in a multitude of adverse effects, both reversible and irreversible.


A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care.


Kluyvera co-infection in two solid organ transplant recipients: an emerging pathogen or a colonizer bystander?


Persistent right umbilical vein--case report and review of literature.


A 27-year-old man with acute monoblastic leukemia had clinical and laboratory evidence of disseminated intravascular coagulation (DIC), which was exacerbated by induction chemotherapy.


Improvement was dose-dependent, and was limited by irritability and action tremor when the patient was taking 1,600 mg per day.


We report on case histories of two epileptic patients who were initially on lamotrigine and to whom sertraline was added to control psychiatric features.


A 56-yr-old white female administered corticosteroids presented with left ear pain and facial swelling due to cervical subcutaneous emphysema from a diverticular perforation of the sigmoid colon.


After administration of Oxybutynin concomitantly with an increase in the dose of Dantrolene, she presented the clinical symptoms and laboratory finding of Carbamazepine intoxication.


Although the existence of an acute pericarditis or an acute myocarditis as possible causes of the ST elevation cannot be fully ruled out, the sudden onset, prominent magnitude, and brief duration of the ST elevation are perhaps more indicative of an acute ischemic event, possibly related to a transient coronary vasoconstriction induced by the dopamine infusion.


A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.


At present, both patients are in the NYHA class I state and are ready to return to work.