Domain: Healthcare — Human Physiology
Target concept: Healthy Glucose Curve

Video generation prompt: A continuous glucose monitor (CGM) sensor patch attached to a healthy subject's upper arm, who drank 100 g of glucose solution in a fasting state; a display panel shows the subject's blood glucose curve from fasting to 2 hours postprandial.

Evaluation guide:
Target concept: Healthy glucose curve = time-resolved blood glucose response to 100g oral glucose in a fasting, metabolically intact human, defined by three mechanistic hallmarks: (1) stable fasting baseline (intact hepatic glucose output suppression), (2) rapid but bounded postprandial rise (functional β-cell mass + appropriate insulin kinetics), and (3) complete 2-hour recovery (sufficient insulin sensitivity + peripheral glucose disposal). Minimum assumptions: subject is non-diabetic, fasting, and the CGM sensor patch's paired display accurately reflects interstitial glucose dynamics. Expected phased storyline: [Phase 1: Baseline] Subject seated, silent, CGM sensor patch already adhered flat to the skin of the upper arm (no lancet, no finger prick, no blood droplet anywhere in the clip) → stable flat line (70–99 mg/dL) on the display for ≥20 sec → verified fasting state. [Phase 2: Trigger] Subject drinks the entire labeled 100 g glucose solution in one smooth motion → display shows a brief indicator response → 5–10 sec latency → curve begins rising. [Phase 3: Physiology] Curve ascends sigmoidally, peaks 30–60 min at ≤160 mg/dL → then descends continuously → reaches ≤140 mg/dL at the marked 120-min point. Visibility constraints: All critical elements (sensor patch on the arm, cup label reading '100g Glucose', the real-time curve with time-axis markers, and numeric glucose values) must be simultaneously legible within a single frontal medium shot; no occlusion, blur, or off-screen action; the background clock and the on-screen time markers must agree.

Manual:
I. Basic Demonstration Information
Demonstration Title: Healthy Glucose Curve (Oral Glucose Tolerance Test – Normal Response) Demonstration
Subject: Healthcare - Human Physiology - Glucose Metabolism
Demonstration Purpose: To visually demonstrate the characteristic blood glucose fluctuation curve of a healthy individual undergoing a standardized oral glucose tolerance test (OGTT): fasting baseline stability → controlled postprandial rise → timely return toward baseline within 2 hours; to reinforce understanding of pancreatic β-cell function, insulin sensitivity, and diagnostic thresholds for normoglycemia.
II. Demonstration Carrier/Equipment
Core Carrier: Healthy adult human subject (fasting ≥8 h, non-diabetic, no medications affecting glucose); a continuous glucose monitor (CGM) — a small adhesive sensor patch/transmitter worn flat on the skin of the upper arm (or abdomen), paired with a handheld or panel display that shows the live glucose curve; 100 g oral glucose solution in a standardized cup with a visible '100g Glucose' label.
Auxiliary Equipment: Adjustable chair, neutral background, digital clock (visible), on-screen time-axis overlay (0, 30, 60, 120 min), calibrated glucose unit display (mg/dL), color-coded curve trace (blue = baseline, red = peak, green = 2h recovery).
III. Demonstration Content Description
Layout: Subject seated comfortably; CGM sensor patch already adhered flat to the skin of the upper arm, fully visible with no wires and no lancet device anywhere in frame; glucose cup placed within natural reach; the CGM display panel and clock both fully visible in frame.
State Control: Subject remains still and calm (no talking, chewing, or physical exertion); the CGM display begins baseline recording for ≥20 sec pre-drink to confirm fasting stability.
Temporal Progression: (1) Baseline stabilization (0 min, 70–99 mg/dL, flat ≥20 sec); (2) Subject drinks the entire 100 g glucose solution (clear liquid, labeled cup, completed within 2–3 sec); (3) Curve rises smoothly, peaks 30–60 min at ≤160 mg/dL; (4) Curve declines steadily, reaching ≤140 mg/dL at the marked 120 min.
IV. Observation of Core Phenomena
Fasting Baseline: Flat, stable trace (±5 mg/dL max variation) for ≥20 sec before the drink; value within 70–99 mg/dL.
Post-Drink Response: Smooth, sigmoid-shaped rise with no overshoot or oscillation; peak amplitude and timing physiologically constrained (120–160 mg/dL, 30–60 min).
2-Hour Recovery: Clear downward slope concluding at ≤140 mg/dL; value marked with green highlight and '2h' label.
Visual Feature Recognition: Curve must be distinguishable from pathological patterns (e.g., diabetic flat peak >200 mg/dL + no decline; reactive hypoglycemia dip <60 mg/dL at 3–4h) by three signature features: (a) baseline stability, (b) bounded peak, (c) timely recovery — all simultaneously visible in a single coherent timeline.
V. Summary of Key Knowledge Points and Principles
Core Concept Definition: A healthy glucose curve reflects intact glucose homeostasis: rapid insulin secretion in response to hyperglycemia, effective peripheral glucose uptake, and hepatic glucose suppression — resulting in a transient, self-limiting glycemic excursion.
Clinical Significance: The 2-hour ≤140 mg/dL threshold defines normal glucose tolerance (per WHO/ADA); deviation indicates impaired fasting glucose, impaired glucose tolerance, or diabetes mellitus.
Physiological Principle: Glucose absorption → β-cell depolarization → insulin exocytosis → GLUT4 translocation → muscle/adipose glucose uptake → hepatic glycogen synthesis → blood glucose normalization.
VI. Demonstration Precautions
Fasting Verification: Visual cue required (e.g., a 'Fasting: 8h' badge or clock + 'last meal 12am' text); no food/drink (except water) visible.
Sensor Integrity: The CGM sensor patch must appear securely and flatly adhered to the arm's skin at all times; no lancet, no finger-prick device, no blood droplet, and no puncture site anywhere in the clip; the display's status indicator (if present) stays active and steady.
Graph Fidelity: Curve rendered as a continuous, smoothly drawn line with real-time timestamp sync and no visible skips; axis labels unambiguous ('Time (min)', 'Glucose (mg/dL)').
Duration Constraint: Full 2-hour physiology compressed into 10 sec video using kinematically faithful acceleration: baseline (2 sec), drink + lag (1 sec), rise (3 sec), peak + decline (4 sec) — preserving all inflection points, slopes, and relative durations proportionally.

Prompt Grounding rubric:
level_1: No CGM sensor patch or display, no human subject, no glucose-solution cup, no graph/curve, or no recognizable sequence (seated/fasting → drinking → monitoring); core setup elements are missing or unrecognizable.
level_2: At least one core setup element is present (e.g., a device resembling a glucose monitor, OR a person, OR a labeled drink cup), but with a clear setup mismatch: e.g., the subject eats solid food instead of drinking the glucose solution, a lancet or finger-prick device appears instead of the CGM sensor patch, no display or graph is ever shown, or the drinking event appears after the curve has already risen.
level_3: Core setup objects are present and identifiable: a CGM sensor patch visible on the subject's arm, the subject drinking a clear liquid from a cup, and a display panel showing some form of curve or line, but with omissions: e.g., the cup's glucose-amount label is never legible, the display shows only static numbers with no visible curve, or no fasting/rest period is shown before the drink.
level_4: All core setup elements and their order are correctly shown: (1) subject seated with the CGM sensor patch already adhered to the arm (no lancet, no finger sensor, no blood droplet visible), (2) subject drinking from a cup legibly labeled with the glucose amount, (3) a curve visibly appearing and evolving on the display only after the drink; minor flaws only, e.g., the cup label is legible for just a couple of frames, or the display's time-axis markers are faint.
level_5: Perfect setup fidelity: (a) healthy adult subject seated calmly with a visible fasting cue (e.g., a 'Fasting: 8h' badge or an early-morning clock reading); (b) CGM sensor patch clearly and securely adhered flat to the arm's skin, with no lancet, no finger prick, and no blood droplet anywhere in the clip; (c) subject drinks from a cup clearly labeled '100g Glucose' in one continuous motion; (d) the display panel shows a curve that only begins evolving after the drink, with legible time-axis and glucose-value labels throughout; the sensor patch and display keep consistent size and placement from start to end, while the cup's on-screen size may naturally change as it is lifted to drink.

Scientific and Causal Correctness rubric:
level_1: Curve shows biologically impossible behavior: e.g., an immediate spike to >300 mg/dL at '0 min', a monotonic rise that never turns over by 2h, a flatline at a hypoglycemic level (<50 mg/dL), or negative values; no causal link between drinking the glucose solution and the curve changing; the display shows an unrelated signal (e.g., heart rate, ECG) instead of a glucose curve.
level_2: Curve changes but violates core OGTT physiology: e.g., the peak occurs within 5 min of the drink (far too fast for gut absorption and insulin response), there is no decline by 2h (persistent hyperglycemia), or the pre-drink baseline oscillates by more than ±10 mg/dL; the drinking event is visually disconnected from the curve's response (curve moves before the drink, or never responds after it); the display freezes or goes blank during a key phase (baseline, rise, or decline).
level_3: Curve follows the general OGTT shape (baseline → rise → peak → decline) but with quantitative errors: peak above 160 mg/dL or below 120 mg/dL, 2h value above 140 mg/dL, or baseline outside 70–99 mg/dL; causal timing is weak, e.g., the curve begins rising about 10 sec after the drink (plausible) but shows no visibly stable baseline beforehand; whether the CGM sensor patch is actually driving the curve is ambiguous (patch appears loose, or the curve's motion does not clearly follow from the drink).
level_4: Curve is quantitatively accurate for a healthy OGTT: baseline 70–99 mg/dL stable for ≥20 sec, peak 120–160 mg/dL reached at 30–60 min, 2h value ≤140 mg/dL; the causal chain is visible and synchronized: drink finishes → 5–10 sec delay → curve begins rising → smooth ascent then descent; the CGM sensor patch is visibly and securely attached throughout, with no extraneous physiological signals or motion artifacts distorting the trace.
level_5: Full scientific fidelity: (a) the baseline shows physiological fasting stability (fluctuation ≤±5 mg/dL over the 20 sec before the drink); (b) the post-drink rise shows characteristic sigmoid kinetics (a brief lag, then a faster rise, then a leveling near the peak); (c) the peak is 140±10 mg/dL at 45±5 min; (d) the 2h value is 110±10 mg/dL with a still-declining slope; (e) the causal logic is explicit: the drink finishing is immediately followed by a brief response on the display, then a smooth, artifact-free curve; all units and axis labeling conform to standard mg/dL clinical OGTT conventions; no competing activity (talking, walking, or visible stress) accompanies the measurement.

Spatiotemporal Consistency rubric:
level_1: Severe spatiotemporal violations: e.g., the subject drinks the glucose solution while the CGM sensor patch is visibly detached or absent from the arm; the curve on the display updates before the drinking motion finishes; the timeline jumps instantly from 0 min to 2h with no intermediate curve motion; the sensor patch disappears from the arm and later reappears; the subject's arm/hand position is inconsistent with having just performed the drinking motion; the room lighting shifts abruptly (e.g., day to night) within a single cut with no visible cause.
level_2: Multiple discontinuities: e.g., the cup vanishes right after the sip and then reappears; the curve resets to zero while it is still rising; the display flickers with icons unrelated to a glucose curve; the subject's head or posture changes unnaturally between consecutive frames; more than 3 sec elapses between the drink finishing and the curve's first movement with no visible reason.
level_3: Minor but noticeable inconsistencies: e.g., the subject's arm shifts position slightly between the drinking motion and the monitoring phase even though the patch is never disturbed; the curve's time-axis tick marks don't line up with the numeric time shown; background details (the clock face, a wall poster) subtly change between the baseline shot and the 2h shot.
level_4: High spatiotemporal coherence: the subject keeps a steady seated posture and arm position throughout; the display's curve updates smoothly frame to frame with no resets or flicker; the drink-to-curve-onset latency stays roughly constant (~7±2 sec); the background clock advances in step with the on-screen time markers (0 → 30 → 60 → 120 min); the sensor patch, cup, and display keep the same size and shape across the whole clip.
level_5: Perfect continuity: (a) the CGM sensor patch stays fixed and undisturbed on the subject's arm from baseline through the 2h mark; (b) the curve on the display is drawn as one continuous, unbroken line with no visible jumps or teleporting segments, with its timestamp advancing steadily; (c) the background clock matches the on-screen time markers exactly (e.g., 't=0 min' lines up with the clock reading 8:00, 't=120 min' with 10:00); (d) the cup's apparent size changes naturally with its distance from camera during the drinking motion and stays static once set down; (e) no frame duplication or stutter appears anywhere in the clip, and the 2-hour physiology is compressed into 10 seconds only through a uniformly accelerated but kinematically consistent curve progression, without the subject's own motions being sped up or slowed unnaturally.