Domain: Healthcare — Pharmacy
Target concept: Effect of Chewing Pretreatment on the Release Rate of the Drug

Video generation prompt: Two identical transparent containers filled with still water are placed side by side. A pre-crushed chewable tablet is placed in the left container, and a whole tablet of the same specification is placed in the right container. The release behavior is observed.

Evaluation guide:
(i) Target concept: Surface area modulation directly governs dissolution kinetics in solid oral dosage forms.
Minimum mechanism: Crushed tablet must expose significantly greater solid-water interfacial area than the whole tablet, enabling faster molecular diffusion into aqueous phase, observable as earlier onset of particle detachment and localized turbidity, without requiring full dissolution.
(ii)Storyline: Frame 0–1: Static wide shot showing two identical transparent containers side-by-side, both filled with still water, background neutral and evenly lit. Frame 2–3: Hands (or mechanical placement) simultaneously introduce crushed mass into left container and whole tablet into right container; both land gently on container base. Frame 4–10: Continuous observation: left-side crushed mass begins shedding ≥2 distinct fragments and generating a stable, confined halo of fine dispersion; right-side whole tablet retains sharp edges, uniform color, and zero surface disruption, all under fixed frontal viewpoint with no camera motion, no lighting change, and no occlusion.

Manual:
Experimental Procedure
1. Place two identical transparent containers side by side on a flat surface.
2. Fill both containers with equal volumes of still water.
3. Place a pre-crushed chewable tablet into the left container.
4. Place an intact whole tablet of identical specification into the right container.
Observation of Experimental Phenomena
The crushed tablet in the left container shows early particle separation and localized water clouding around the mass; the whole tablet in the right container remains fully intact with no visible dissolution or surface erosion throughout the observation period.
Summary of Experimental Principles
Chewing pretreatment increases surface area-to-volume ratio, accelerating the initial dissolution rate of the drug — demonstrated by faster onset of visible release phenomena in the crushed formulation compared to the intact tablet.

Prompt Grounding rubric:
level_1: No two side-by-side transparent containers are visible; neither container holds a tablet; only one container appears in frame; the containers are not filled with still water; no crushed or chewable tablet material is shown at all.
level_2: Two transparent containers are present and placed side by side, both filled with water, but: (a) both hold whole intact tablets, or (b) both hold crushed material, or (c) one container holds an unrelated object such as loose powder, a capsule, or a candy instead of a tablet, or (d) the crushed-versus-whole distinction cannot be told apart because of matching appearance or an object blocking the view.
level_3: Two transparent containers are placed side by side, both filled with still water; the left container holds a visibly fragmented, crushed solid mass consistent with a chewed tablet; the right container holds a single intact, unbroken tablet matching the left tablet's original size, shape, and color; no other object is introduced into either container.
level_4: All conditions for score 3 are met, AND the tablet (or crushed remnant) is placed into each container at essentially the same moment, with neither container receiving its contents noticeably before the other; the two containers hold visibly equal water volumes and sit at the same height and distance from the camera; the crushed material in the left container rests as a compact cluster at the container's base rather than already scattered or floating; the whole tablet in the right container rests on the base with no crack, chip, or surface change visible at the moment of placement.
level_5: All conditions for score 4 are met, AND the two containers stay aligned side by side with no shift in their relative spacing or orientation for the entire shot; the camera keeps both containers and their full contents in view at all times, with no hand or other object blocking either one after placement; the water in both containers is equally clear and equally still immediately after placement, giving a fair, simultaneous starting condition for comparing the two tablets.

Scientific and Causal Correctness rubric:
level_1: The crushed tablet in the left container shows no dissolution activity while the whole tablet in the right container disintegrates rapidly, the reverse of the expected outcome; both tablets dissolve in an identical manner and on the same timeline; visible dissolution begins before either tablet has touched the water; a color change appears in the water with no chemical basis, such as an unexplained dye leaching from a plain tablet.
level_2: The crushed tablet stays completely inert, with no particle separation, halo, or clouding, while the whole tablet shows rapid disintegration instead; both tablets show identical dissolution timing and appearance; any dissolution that does occur starts from the surfaces exposed to air rather than the surfaces in contact with the water.
level_3: The crushed tablet shows visible dissolution activity, whether separating particles, a localized cloudy halo, or both, earlier than the whole tablet does; the whole tablet shows no sign of dissolution: no softened edges, no blurring, no clouding around it; both tablets stay within their original containers with no material crossing between the two.
level_4: All conditions for score 3 are met, AND the dissolution activity around the crushed tablet stays confined to the immediate area around the cluster, without clouding the bulk of the water or spreading evenly through the whole container; the water around the whole tablet stays fully clear and its outline stays sharp, together showing that the crushed tablet's larger exposed surface area is what drives its faster initial release.
level_5: All conditions for score 4 are met, AND at least two distinct fragments visibly separate from the crushed tablet's main cluster over the course of the video, while the whole tablet keeps its original shape and sharp edges with no visible softening, demonstrating that chewing increases the rate of release, not merely whether release eventually happens.

Spatiotemporal Consistency rubric:
level_1: Either container appears to jump to a different position between frames; a tablet appears or disappears without any placement action shown; the water's surface flickers violently or its level changes abruptly between frames; the shadows cast by the containers shift direction or vanish partway through the otherwise static shot; the camera cuts or rotates to a different angle mid-sequence.
level_2: One container shifts position relative to the other between frames; a tablet moves sideways or rotates with no physical cause; the water surface shows a ripple that appears and vanishes without decaying naturally; crushed particles appear to float upward and then instantly drop, with no continuous path connecting the two positions.
level_3: Both containers stay in the same side-by-side arrangement and spacing throughout the shot; neither tablet moves on its own after being placed; the water surface in both containers stays flat and undisturbed except where a tablet or particle causes a localized effect; no object flickers, warps, or changes shape unexpectedly; the light source's direction and brightness stay the same across the whole shot.
level_4: All conditions for score 3 are met, AND the crushed particles settle together as a group rather than scattering apart or bouncing; the whole tablet contacts the container base and stays in a stable resting position without rocking or tipping; no frame appears duplicated, frozen, or played out of order; any settling motion is smooth and moves in one consistent direction rather than reversing.
level_5: All conditions for score 4 are met, AND there is no mismatch between how sharp or blurred the settling particles look from one frame to the next; the two containers keep the same relative distance and angle to each other and to the camera throughout; no particle or tablet edge appears to jump or teleport between consecutive frames; the perspective on both containers stays consistent with no sudden distortion.