Domain: Healthcare — Human Physiology
Target concept: Allergy

Video generation prompt: Apply a small amount of menthol solution to the arm of a patient allergic to menthol using a cotton swab.

Evaluation guide:
(i) Target concept: Safe, controlled cutaneous allergen challenge using menthol as a model contact allergen.
Minimum mechanism: Menthol solution must be applied topically in liquid form to intact epidermis; no immune activation occurs within 10 seconds; only physical wetting is observable.
(ii)Storyline: [Frame 0–2] Container opens → [Frame 3–4] Swab enters container and becomes saturated → [Frame 5–6] Swab withdraws with visible liquid load → [Frame 7–8] Swab moves in uninterrupted trajectory to forearm → [Frame 9] Contact initiates, wet patch appears *only* at point of contact; all events occur from fixed frontal/slightly angled clinical viewpoint; arm remains fully visible and static; no secondary actors, labels, or UI overlays.

Manual:
Experimental Procedure
1. Open small container of colorless menthol solution.
2. Dip cotton swab into solution until tip is saturated.
3. Gently apply swab tip to clean, dry forearm skin in single controlled motion.
Observation of Experimental Phenomena
A localized, translucent wet patch appears exclusively at the contact site on the skin; no immediate erythema, swelling, or irritation occurs.
Summary of Experimental Principles
Menthol can act as a topical irritant or contact allergen in sensitive individuals, but it is not one of the standardized allergens included in clinical patch-test panels, and documented menthol hypersensitivity reactions are typically immediate contact irritation rather than delayed-type (Type IV) hypersensitivity. This scene depicts only the initial physical step of a hypothetical challenge — applying a small liquid volume to intact skin with a cotton swab — and shows no immune response, since a genuine reaction of either kind would take far longer than this timescale to become visible.

Prompt Grounding rubric:
level_1: None of the three core props (the cotton swab, the patient's forearm, and the small menthol-solution container) appear together in the scene, or the scene depicts an unrelated setting (no healthcare/testing context at all) or a different application method (such as an injection or oral dosing) instead of a swab.
level_2: At least one of the three core props (swab, forearm, small liquid container) is visible, but not all three appear together in the same shot, or the container shown is clearly the wrong type of object for a topical liquid (e.g., a syringe, pill bottle, or spray canister), and no contact between swab and arm is shown.
level_3: The cotton swab, the forearm, and the small liquid container all appear together in the same shot, and the swab visibly touches the arm, but the footage falls short in one of two ways: either no wet patch or wetness ever appears on the skin despite the contact, or it's unclear whether the swab is a soft cotton-tipped applicator rather than a hard rod/brush and whether the container is open or holds any visible liquid.
level_4: The swab is clearly a soft, white, fibrous cotton-tipped applicator (not a rigid rod or brush), the forearm shows plausible bare human skin, and the container is small, open or uncapped, with visible liquid inside; a wet patch appears where the swab touches the arm, but the container carries legible text/labeling inconsistent with a menthol solution (e.g., naming an unrelated drug), or the swab is dipped and touched to more than one spot on the arm, contradicting a single controlled application.
level_5: The swab is a soft, white, fibrous cotton-tipped applicator, the forearm is plausible bare human skin, and the container is small and open with visible liquid; the swab is shown entering or touching the liquid, withdrawing, and then moving in one uninterrupted motion to a single point on the arm, where a wet patch appears only at that one site; the container carries no text or labeling that contradicts a menthol/topical solution, and no other hands, tools, or actions appear in the shot.

Scientific and Causal Correctness rubric:
level_1: Either no attempt to apply the solution occurs at all (no liquid transfer depicted), or a visible allergic reaction (redness, swelling, hives, or blistering) appears on the skin during or immediately after the swab's contact, which is physiologically impossible on this timescale for a genuine hypersensitivity response and unsafe for a real challenge protocol.
level_2: The solution is applied, but the depicted physical event is not really a liquid-to-skin transfer, for example the droplet behaves like a solid bead that does not wet the skin, the swab tip appears to dissolve or disappear into the arm, or the skin's color changes as if reacting instantly to contact, none of which matches the physics of a liquid wetting intact skin or the timescale of any true immune response.
level_3: The liquid visibly wets the skin exactly where the swab makes contact (correct, since surface wetting is essentially instantaneous), and no redness, swelling, hives, or blistering appears anywhere on the arm (correct, since a genuine hypersensitivity reaction takes far longer to develop), but the wet patch spreads to cover a large fraction of the forearm well beyond the small volume carried by the swab tip, overstating how far such a small amount of liquid would actually spread.
level_4: The wet patch stays confined to an area proportionate to the small volume carried by the swab tip, and no swelling, hives, or blistering appears anywhere on the arm, but the skin right at the contact site shows a faint reddish tint, which is inconsistent with the timescale needed for any real immune-mediated skin reaction to develop.
level_5: The wet patch stays confined to an area proportionate to the small volume carried by the swab tip, and the skin's color and texture everywhere on the arm, including at the contact site, remain unchanged apart from the visible wetness, correctly reflecting that no immune-mediated reaction could yet be visible at this timescale.

Spatiotemporal Consistency rubric:
level_1: The forearm, cotton swab, or menthol-solution container vanishes and then reappears between frames, or the swab jumps directly onto the arm from off-screen with no visible travel, or the forearm's position or angle changes abruptly between shots while the swab stays still, or the lighting on the scene abruptly shifts between bright and dark with no visible cause.
level_2: The swab's path from the container to the arm breaks into visibly disconnected jumps (appearing at clearly different spots in consecutive frames rather than sweeping continuously across the space between), or the wet patch is visible on the skin before the swab ever makes contact, or the swab or forearm flickers or briefly changes shape during the motion.
level_3: The swab travels along one continuous, visible path from the container to the single point of contact on the forearm without disappearing or relocating instantly; the forearm holds the same position and orientation throughout; the container does not shift position on its own, but the swab briefly leaves the camera's view partway through its travel, or the wet patch fades out and back in during the sequence.
level_4: The swab, container, and forearm all remain within the frame for the entire sequence; the swab's movement from container to skin is one smooth, unbroken sweep with no visible skips; the wet patch appears at the moment of contact and does not flicker afterward, but there is a noticeable pause between the moment of contact and the wet patch's appearance, or a faint doubled outline briefly appears around the patch.
level_5: The swab is shown wetted at the container, withdrawn, and carried in one unbroken motion directly to a single point on the forearm, with the wet patch appearing at the exact moment of contact and remaining stable afterward; the forearm stays motionless and fully visible throughout; nothing in the sequence shows the swab, container, or arm jumping, freezing, or changing size or shape inconsistently with a single continuous camera view.