Domain: Healthcare — Human Physiology
Target concept: The effect of epinephrine on heart rate (simulation)

Video generation prompt: A digital heart rate monitor displays the resting heart rate. Epinephrine is administered in the simulation model. The monitor continuously updates to show changes in heart rate over time. All procedures are performed in sequence and are clearly demonstrated.

Evaluation guide:
(i) Target concept: Sympathetic pharmacologic stimulation of heart rate via epinephrine receptor activation.
Minimum mechanism: Epinephrine must be delivered to systemic circulation (IV/IM route) and act on cardiac pacemaker cells; heart rate response must be excitatory, monotonic, and temporally coupled to delivery.
(ii)Storyline: Frame 1–3: Static shot of digital monitor displaying stable resting HR (e.g., 72 bpm); no motion. Frame 4–6: Epinephrine administration action initiated and completed (e.g., syringe needle contacts skin or liquid dispenses into IV line) — same camera view, no cut. Frame 7–10: Heart rate digits update sequentially upward (e.g., 72→84→96→108→120), with no intermediate drops or resets; all frames maintain identical framing, lighting, and object positions; monitor remains fully visible and legible throughout.

Manual:
Experimental Procedure
1. Display digital heart rate monitor showing stable resting heart rate (e.g., 72 bpm).
2. Administer epinephrine via simulated IV push or intramuscular injection.
3. Monitor updates continuously to show progressive increase in heart rate.
Observation of Experimental Phenomena
- Initial numeric heart rate value is stable and within 60–100 bpm.
- After epinephrine administration, heart rate value increases monotonically to ≥110 bpm.
- No decrease, pause, or reversal occurs during the rise.
Summary of Experimental Principles
Epinephrine binds to cardiac β₁-adrenergic receptors, increasing sinoatrial node firing rate and myocardial contractility, resulting in elevated heart rate—a hallmark sympathetic nervous system response.

Prompt Grounding rubric:
level_1: No digital heart rate monitor is visible, no epinephrine administration action (a vial, syringe, or injection motion) appears, and the heart-rate reading never changes; none of the three required elements - monitor, administration action, and updated reading - appears anywhere in the video.
level_2: At least one of the three required elements appears (for example, the monitor alone with no administration action shown), but the depiction is incomplete or out of order: the heart-rate reading changes with no administration action ever shown, or the administration action is shown only after the reading has already changed.
level_3: The monitor is visible and shows a starting numeric heart-rate reading; the epinephrine administration is shown as a distinct visual action (for example, a syringe or labeled vial moving toward an injection site or IV line); the reading changes at some later point in the video; however the link between the action and the change is loose - for example, an unexplained pause separates them, or the administration action is repeated more than once.
level_4: The monitor is continuously visible and legible, showing a stable starting reading; the epinephrine administration is shown once, as a single unambiguous action (the needle reaching the injection site, or liquid entering the IV line); the reading begins changing directly after that single action; the monitor, administration props, and simulated patient keep the same relative positions throughout, with no extra steps or unrelated elements added.
level_5: The monitor stays centered and fully legible for the whole video; the administration prop is recognizable as an injectable device - a syringe and vial, or an IV bag/line - rather than a pill, inhaler, or topical applicator; the administration occurs exactly once and is immediately followed by the reading changing on that same monitor through one coherent sequence of updates (whether shown as a continuous roll or a few sequential digit changes), with no flicker, no reset back to the starting value, and no repeat of the administration action; no extra person, camera, or prop enters or exits the frame, and no on-screen text or overlay appears beyond the monitor reading and the administration props.

Scientific and Causal Correctness rubric:
level_1: The heart-rate reading decreases or stays unchanged after the epinephrine administration action; the monitor shows a physiologically impossible reading at any point (below 20 or above 250 bpm); the epinephrine is shown as a swallowed tablet or topical cream rather than an injected drug; or there is no visible temporal connection between the administration action and any change in the reading.
level_2: The heart-rate reading increases, but the increase begins before the administration action is shown; the displayed unit changes partway through the video (for example, switching from bpm to Hz); the epinephrine is administered to a site inconsistent with delivering a drug into the bloodstream (for example, the eye or ear); or the reading jumps directly from a normal resting number to a high number within a single frame with no intervening readout.
level_3: The reading rises after the administration action; the starting value falls within a normal resting range (60-100 bpm) and the ending value is elevated (110 bpm or higher); but the rise is not steadily upward - for example, it dips before climbing, or passes through an implausible intermediate number - and/or the vial or syringe used for administration shows no cue (such as an IV line or an injection into the arm) that this is an injectable route.
level_4: The reading starts within 60-100 bpm and rises without any drop, plateau, or reversal to 110 bpm or higher, beginning only after the administration action; the epinephrine is delivered by a route consistent with an emergency injectable (an IV push or an intramuscular injection into the arm) rather than an implausible route; every displayed number uses the same unit (bpm); and no contradictory physiological cue (such as a flat ECG line running at the same time) appears on screen.
level_5: The reading rises continuously and only upward, from a physiologically normal resting value (for example, 72 bpm) to a sustained elevated value (for example, 130 bpm or higher), with no frame showing a decrease or plateau once the rise begins; the timing of the rise starts within a few seconds of the administration action, consistent with epinephrine's fast onset, rather than being delayed by many seconds or beginning early; and no competing stimulus in the scene (such as a separate alarm sound or unrelated stress cue) offers another explanation for the change in reading.

Spatiotemporal Consistency rubric:
level_1: The heart-rate monitor jumps to a different part of the screen between frames; the epinephrine vial or syringe appears or disappears without a hand visibly carrying it into or out of frame; the heart-rate digits vanish and reappear in a different size, font, or screen position; the scene's lighting swings abruptly from fully lit to near-total darkness within a single frame with no visible cause; or the simulated arm/torso changes shape or proportion between shots.
level_2: The monitor's on-screen position shifts noticeably - by roughly half its width or more - between the start and end of the video; the syringe or vial moves in visible jumps rather than one continuous motion; the heart-rate digits go blank for more than a moment during an update; or the room's lighting or background visibly changes character partway through with no visible light source to explain it.
level_3: The monitor stays in the same place and at the same size throughout; the administration action stays within the same shot as the monitor; the heart-rate digits update in place without shifting position or changing font; but a viewer can still notice a small blemish - for example, a digit briefly looking smudged during an update, or the syringe's motion looking slightly uneven for an instant.
level_4: The monitor, administration props, and simulated patient all keep the same relative positions and sizes throughout; the heart-rate digits change only in numeric value, never in position, size, or transparency; the administration motion moves at one steady speed and direction from start to finish; the room's lighting and the direction of visible shadows look the same across the video; and no frame shows a visible seam, warp, or double-exposure on any object.
level_5: To an ordinary viewer, nothing in the frame drifts, flickers, or jumps: the monitor and its digits, the syringe or vial, and the simulated patient all stay exactly where they were placed relative to one another; the digit updates read as one clean, continuous progression rather than a glitchy skip; the administration motion looks like a single smooth real-world gesture; and the overall brightness and color of the scene look the same from the first frame to the last, with no noticeable blur, ghosting, or double image on any object or digit.