Domain: Healthcare — Pharmacy
Target concept: Enteric-coated tablets compared to uncoated tablets that dissolve in acidic media

Video generation prompt: Place one enteric-coated glossy tablet and one uncoated matte tablet side by side in a transparent beaker containing acidic liquid, ensuring they are completely submerged and remain stationary.

Evaluation guide:
(i) Target concept: Differential dissolution behavior governed by polymer coating pH-sensitivity.
Minimum mechanism: Acid-labile coating (e.g., cellulose acetate phthalate) remains insoluble below pH 5.5; uncoated tablet matrix (e.g., microcrystalline cellulose) hydrates and disintegrates spontaneously in acid.
(ii)Storyline: Frame 0–1: Static wide shot reveals transparent beaker with two distinct tablets side-by-side, fully submerged in amber acidic liquid. Tablet A (left) displays sharp specular highlights → glossy → enteric-coated. Tablet B (right) shows zero highlights and diffuse reflectance → matte → uncoated. Frames 2–9: Uncoated tablet exhibits continuous, localized surface disruption (clouding at edges, fine particulates detaching into liquid); enteric tablet remains optically invariant: no texture change, no edge rounding, no particle emission. No motion of tablets or liquid surface. Viewpoint remains fixed frontal, full-beaker framing with even illumination.

Manual:
Experimental Procedure
1. Place one enteric-coated tablet (glossy surface) and one uncoated tablet (matte surface) side-by-side in a transparent cylindrical beaker.
2. Fill with acidic liquid (e.g., dilute HCl solution, amber-tinted to indicate low pH) until both tablets are fully submerged.
3. Ensure tablets rest motionlessly on the beaker base, maintaining fixed side-by-side positions.
Observation of Experimental Phenomena
The uncoated tablet shows progressive surface degradation (clouding, edge softening, particle release) while fully submerged; the enteric-coated tablet remains intact, glossy, and geometrically unchanged — no dissolution or erosion observed.
Summary of Experimental Principles
Enteric coatings resist dissolution in acidic environments (e.g., stomach pH 1–3), whereas uncoated tablets dissolve rapidly in acid. This protects drug payload from gastric degradation and enables targeted intestinal release.

Prompt Grounding rubric:
level_1: No beaker is visible, or no tablets are visible, or only one tablet appears, or the tablets are not fully submerged in liquid, or they are not placed side-by-side, or the container is opaque rather than transparent, or there is no visual indication the liquid is acidic (e.g., plain clear water with no tint, label, or other acid cue), or the tablets are continuously drifting or rotating rather than stationary.
level_2: A transparent beaker holds two tablets side-by-side, but at least one of the following is missing: (a) both tablets are not fully submerged: part of one breaks the surface or rests above the liquid line; (b) the tablets are not stationary: one visibly drifts, rotates, or settles partway through the clip; (c) there is no visual cue that the liquid is acidic: no amber/yellow tint, no legible label such as 'HCl' or 'gastric fluid', no pH-indicator coloration; (d) the two tablets look identical in surface finish, so a viewer cannot tell which one is the glossy enteric-coated tablet and which is the matte uncoated one.
level_3: A transparent beaker contains both tablets, clearly placed side-by-side and fully submerged, remaining stationary for the whole clip; the liquid shows a visual cue of acidity (a uniform amber/yellow tint, a legible 'HCl solution'/'gastric fluid' label, or a pH-indicator color consistent with an acid); and the two tablets are visually distinguishable by finish: one shows a glossy, reflective surface (enteric-coated) and the other a flat, matte surface (uncoated).
level_4: Beyond the 3-point requirements, the two tablets share the same shape (e.g., both round, or both oblong) and the same base color (e.g., both white), so surface finish (not shape or color) is what distinguishes them; no unrelated objects intrude on the shot (no fingers, dropper, or rising air bubbles, and no meniscus distortion obscuring the tablets); and the camera holds a level, front-facing view that keeps the side-by-side placement clearly visible.
level_5: Beyond the 4-point requirements, the glossy tablet shows clear specular highlights consistent with a smooth, non-porous coating, while the matte tablet shows no such highlights and a uniformly diffuse surface; the liquid surface stays still and flat, without ripples; the two tablets stay at a visually constant distance from each other, neither drifting closer nor farther apart; and the lighting is even and neutral, without colored casts or glare that would hide either tablet's surface texture.

Scientific and Causal Correctness rubric:
level_1: No dissolution difference is visible between the two tablets: both look unchanged, or both show the same degree of surface change; or the uncoated tablet stays intact while the enteric-coated tablet is the one that visibly degrades (the reverse of the real chemistry); or any dissolution appears before the tablets are submerged, or happens instantly/explosively rather than gradually.
level_2: Some change is visible, but the cause-and-effect is wrong or muddled: (a) the enteric-coated tablet shows surface erosion, pitting, or disintegration while the uncoated tablet shows no visible change; or (b) both tablets show the same kind of surface change (e.g., both cloud over, both shed particles), so there is no visible difference between coated and uncoated behavior.
level_3: The uncoated tablet visibly degrades over the course of the clip (showing signs such as edge softening, surface clouding, or particles shedding into the liquid), while the enteric-coated tablet keeps its glossy surface and original shape with no visible degradation; which tablet degrades and which stays intact is never ambiguous or reversed.
level_4: Beyond the 3-point requirements, no dissolution-like marks (clouding, pitting, or particle shedding) are visible anywhere on the enteric-coated tablet: it stays visibly untouched throughout; the uncoated tablet's degradation builds up gradually rather than appearing or vanishing abruptly; and nothing on the enteric-coated tablet's surface (such as an air bubble clinging to it or floating debris drifting past) could be mistaken for dissolution.
level_5: Beyond the 4-point requirements, any clouding or haze around the uncoated tablet stays close to its own surface in the liquid rather than spreading to surround or obscure the enteric-coated tablet; the enteric-coated tablet keeps sharp, unbroken edges and even gloss over its entire visible surface; no particles or turbidity trailing from the enteric-coated tablet are visible at any point; and the way the uncoated tablet breaks down (e.g., gradually smoothing versus visibly flaking) looks consistent with a single degrading material rather than switching character partway through.

Spatiotemporal Consistency rubric:
level_1: A tablet's position or size jumps abruptly between frames with no continuous motion; the beaker's outline warps into an unrecognizable shape or vanishes entirely for a frame; the lighting flashes or flickers violently; a tablet suddenly switches between transparent and opaque with no visible cause; or the liquid's surface level jumps up or down between frames with no visible cause.
level_2: A moderate continuity break: (a) a tablet shifts by more than its own width between consecutive frames with no motion blur to account for the jump; (b) one wall of the beaker bends or kinks slightly without becoming unrecognizable; (c) a highlight on a tablet's surface jumps to a different spot with no corresponding change in the scene's lighting; (d) the liquid's meniscus height changes abruptly with no visible cause such as an added substance.
level_3: The two tablets keep a stable side-by-side arrangement throughout the clip; the distance between them stays constant, neither drifting closer nor farther apart; the beaker walls stay rigid, straight, and parallel; the liquid level stays constant; and neither tablet clips through the beaker wall, stretches, or otherwise changes shape unnaturally.
level_4: Beyond the 3-point requirements, both tablets and the beaker stay completely still: no visible drift of either tablet or the beaker walls; any shadows cast by the tablets or beaker stay fixed in position and match a single consistent light direction, with no shadow appearing to float free of its object; and the clip plays smoothly with no visible jitter or repeated/frozen frames.
level_5: Beyond the 4-point requirements, the tablet edges and the liquid meniscus stay sharply and smoothly defined across the whole clip, with no flickering or double-image trailing from frame to frame; the video keeps a consistent, even focus across the whole scene rather than one tablet or region turning soft while the rest stays sharp; and no visible blockiness or stray color fringing appears along the tablet edges or in the liquid.