Domain: Healthcare — Pharmacy
Target concept: Differences in Skin Permeation between Gels and Ointments

Video generation prompt: Two identical simulated skin membrane samples are mounted flat over two clear collection dishes, with a dye-labeled drug gel applied to the top surface of the left membrane and the same dye-labeled drug ointment of the same concentration applied to the top surface of the right membrane, followed by observation from underneath to track how the colored tracer appears in each collection dish over time.

Evaluation guide:
(i) Target concept: Differential rate of drug permeation through skin (a simulated membrane) between gel and ointment vehicles, made visible by a dye tracer crossing the membrane into a collection dish underneath.
Minimum mechanism: The gel vehicle is water-continuous and low-viscosity, so its dissolved dye tracer partitions into and diffuses through the membrane relatively quickly; the ointment vehicle is a high-viscosity, largely lipophilic/occlusive base that releases and moves its tracer through the membrane more slowly, so less tracer reaches the far side in the same time window. (Note: in real long-term use, occlusive ointments can sometimes enhance overall absorption via skin hydration, but over the short observation window depicted here the gel is expected to show the faster, more visible breakthrough.)
(ii)Storyline: Frame 0–1: static wide shot of two identical translucent membrane samples mounted over two clear collection dishes, viewed from underneath, both dishes still clear/colorless. Frame 2–3: dye-labeled gel is applied to the top of the left membrane; dye-labeled ointment of matching tracer color is applied to the top of the right membrane. Frame 4–10: viewed from beneath, colored tracer becomes visible in the left collection dish sooner and in greater amount than in the right dish; no mixing between the two dishes; fixed under-membrane viewpoint throughout, no cuts.

Manual:
Experimental Procedure
1. Mount two identical simulated skin membrane samples over two clear collection dishes, side by side.
2. Apply dye-labeled drug gel to the top surface of the left membrane; apply dye-labeled drug ointment of the same concentration to the top surface of the right membrane.
3. Observe, from beneath the membranes, how much colored tracer passes through into each collection dish over time.
Observation of Experimental Phenomena
Colored tracer appears in the left (gel) collection dish sooner and in greater amount than in the right (ointment) collection dish over the observation window.
Summary of Experimental Principles
Gels are water-continuous, low-viscosity vehicles that release and diffuse a dissolved tracer through a membrane relatively quickly; ointments are viscous, largely lipophilic/occlusive vehicles that release their tracer more slowly, so less tracer crosses the membrane in the same time window. Over long-term clinical use, occlusive ointments can enhance overall skin absorption via hydration, but within this short observation window the gel shows the faster breakthrough.

Prompt Grounding rubric:
level_1: No simulated skin membrane samples or collection dishes are visible; no dye-labeled gel or ointment is ever applied; there is no side-by-side left/right setup; the underside of the membranes is never shown.
level_2: Two flat samples are present but are not recognizable as membranes mounted over clear collection dishes (e.g. the dishes are missing or opaque, or the two samples are stacked rather than side by side); the gel and ointment are not visually distinguishable, or only one of the two formulations is ever applied.
level_3: Two identical membrane samples are visibly mounted over two clear collection dishes, arranged side by side; dye-labeled gel is applied to the top of the left membrane and dye-labeled ointment of matching color is applied to the top of the right membrane; the underside/through-membrane view appears at least once, but the application step or the underside view is shown only briefly or partially.
level_4: All conditions for score 3 are met AND both membrane-and-dish assemblies stay fully visible and correctly positioned (left = gel, right = ointment) for the whole video AND the underside/through-membrane viewpoint is maintained continuously once observation begins, with no hands, tools, or labels blocking either dish.
level_5: All conditions for score 4 are met AND the gel and the ointment are each applied to their membrane in one continuous dispensing action AND both membrane-dish assemblies keep identical size, spacing, and orientation from before application to the end of the video AND no clean-up, repositioning, or swapping of the two sides occurs at any point.

Scientific and Causal Correctness rubric:
level_1: No colored tracer ever appears in either collection dish; or both dishes show identical tracer appearance (same amount, same timing); or the ointment (right) dish shows more or faster tracer than the gel (left) dish; or tracer appears in a dish before its formulation has even been applied.
level_2: Tracer appears in both dishes but the contrast contradicts the expected vehicle behavior: e.g. only a trivial, barely visible difference between the two dishes, or the two dishes swap which one leads partway through, or tracer appears simultaneously and identically in both dishes at every timepoint shown.
level_3: Tracer becomes visible in the left (gel) collection dish measurably sooner and/or in greater amount than in the right (ointment) dish at every timepoint after tracer first appears; the ointment side may show little or no tracer, or a clearly delayed and smaller appearance, throughout the observed window.
level_4: All conditions for score 3 are met AND the gel-side lead is maintained continuously (the ointment dish never overtakes or matches the gel dish in tracer amount at any later frame) AND the tracer's color stays the same distinguishable hue in both dishes throughout.
level_5: All conditions for score 4 are met AND the tracer's first appearance in the gel dish precedes its first appearance (if any) in the ointment dish by a clearly perceptible interval AND the gap in accumulated tracer between the two dishes visibly widens or holds steady over time rather than narrowing, consistent with the gel's faster release and diffusion through the membrane.

Spatiotemporal Consistency rubric:
level_1: One of the membrane-dish assemblies disappears and reappears, or swaps left/right position, between frames; the camera view cuts or jumps to a different angle with no continuous movement, breaking the single fixed underneath viewpoint; tracer color appears in a dish with no visible path connecting it to the applied gel or ointment above; the camera abruptly rotates or cuts.
level_2: The camera view drifts or shifts away from the fixed underneath framing at any point, even briefly, making the viewpoint inconsistent; tracer appears in a dish all at once rather than growing gradually; the gel or ointment application, seen through the translucent membrane from below, shows no visible spreading motion as it is applied.
level_3: Both membrane-dish assemblies stay fully visible, fixed in their left/right positions, and evenly lit throughout; the camera holds a single fixed underneath viewpoint for the entire clip, with no cuts or view changes, from application through observation; tracer spreads into each dish gradually rather than jumping between amounts.
level_4: All conditions for score 3 are met AND the two dishes receive matching, consistent lighting and viewing angle relative to each other at every timepoint AND the tracer's growth in each dish is smooth frame to frame, with no stutter, freeze, or sudden jump in the amount of visible color AND neither membrane nor dish changes size or shape during the sequence.
level_5: All conditions for score 4 are met AND there is no parallax mismatch between the left and right assemblies at any point (they stay in the same rigid spatial relationship to each other and to the camera) AND the single fixed underneath viewpoint is held with no cut or re-angle at any point in the clip AND the tracer's edges remain clearly distinguishable from the surrounding clear liquid/dish at every frame, with no flicker or double-imaging of the color front.