Package: annotation-refinery
The Annotation Refinery python package consists of functions that process
publicly available annotated sets of genes, such as Gene Ontology and Disease
Ontology terms.Configuration filesThe Annotation Refinery requires at least two.iniconfiguration files in
the main directory to run:Amain_config.inifile with the main configuration settings, andAt least one<species>.inifile, which will contain the locations of
the desired annotation files for that species, amon other things. Users can
add configuration files in the main directory for as many species as
they want the refinery to process.Optionally, there can also be asecrets.inifile, which stores values like
usernames and passwords for access to restricted URLs.The Main Configuration FileThe main configuration file includes settings like the location(s) of the
species file(s), where the output of the refinery (the processed genesets)
should be loaded to, where annotation files should be downloaded to,
and optionally, the location of the secrets file.[main]
SECRETS_FILE: secrets.ini
PROCESS_TO: Tribe


# All other download folders in this files should be folders within
# this root folder
[download_folder]
BASE_DOWNLOAD_FOLDER: download_files


[Tribe parameters]
TRIBE_URL: https://tribe.greenelab.com


[species files]
SPECIES_FILES: human.iniThe Species File(s)Each species file should contain the URLs of the desired annotation files to be
downloaded.# File for human settings

[species_info]
SCIENTIFIC_NAME: Homo sapiens
TAXONOMY_ID: 9606
SPECIES_DOWNLOAD_FOLDER: download_files/Human


# ***********************************************
# Below, add as sections the types of annotations
# that should be downloaded and processed
# ***********************************************

[GO]
DOWNLOAD: TRUE

GO_OBO_URL: ftp://ftp.geneontology.org/go/ontology/obo_format_1_2/gene_ontology.1_2.obo
ASSOC_FILE_URL: ftp://ftp.geneontology.org/go/gene-associations/gene_association.goa_human.gz

EVIDENCE_CODES: EXP, IDA, IPI, IMP, IGI, IEP

TAG_MAPPING_FILE: tag_mapping_files/brenda-gobp-all_mapping.dir.v2.txt
GO_ID_COLUMN: 2
GO_NAME_COLUMN: 3
TAG_COLUMN: 1
TAG_FILE_HEADER: TRUE


[KEGG]
DOWNLOAD: TRUE
KEGG_ROOT_URL: http://rest.kegg.jp
DB_INFO_URL: /info/kegg
SETS_TO_DOWNLOAD: /link/hsa/pathway, /link/hsa/module, /link/hsa/disease
SET_INFO_DIR: /get/

# This is the type of gene identifier used by KEGG for this species
XRDB: Entrez

[DO]
DOWNLOAD: TRUE
DO_OBO_URL: http://sourceforge.net/p/diseaseontology/code/HEAD/tree/trunk/HumanDO.obo?format=raw
MIM2GENE_URL: http://omim.org/static/omim/data/mim2gene.txt
GENEMAP_URL: http://data.omim.org/downloads/<SecretKey>/genemap.txt

# This is the type of gene identifier used by DO
XRDB: Entrez

TAG_MAPPING_FILE: tag_mapping_files/tissue-disease_curated-associations.txt
DO_ID_COLUMN: 2
DO_NAME_COLUMN: 3
TAG_COLUMN: 1
TAG_FILE_HEADER: TRUEThe Secrets FileThe secrets file contains things like usernames and passwords for databases,
secret keys for APIs where annotation files will be downloaded from, etc.[OMIM API secrets]
SECRET_KEY: ExampleSecretKey

[Tribe secrets]
TRIBE_ID: asdf1234
TRIBE_SECRET: qwerty1234

USERNAME: example_username
PASSWORD: passwordInstructions for getting an OMIM API secret key can be found here:http://omim.org/downloadsInstructions for getting the Tribe secrets can be found here:http://tribe-greenelab.readthedocs.io/en/latest/api.html#creating-new-resources-through-tribe-s-api