Testicular cancer

Testicular cancer | NHS inform Home Illnesses and conditions Symptoms and self-help Tests and treatments Healthy living Care, support and rights Scotlands Service Directory 0 Home Illnesses and conditions Cancer Cancer types in adults Testicular cancer Testicular cancer About testicular cancer Symptoms of testicular cancer Diagnosing testicular cancer Treating testicular cancer Causes of testicular cancer About testicular cancer Cancer of the testicle is one of the less common cancers. It tends to mostly affect men and anyone with testicles between 15 and 49 years of age. The most common symptom is a painless lump or swelling in one of the testicles . It can be the size of a pea or it may be much larger. Other symptoms can include: a dull ache in the scrotum a feeling of heaviness in the scrotum Its important to be aware of what feelsnormal for you. Get to know your body and speak to your GP if you notice any changes. Read more aboutthe symptoms of testicular cancer and diagnosing testicular cancer . The testicles The testicles are the 2 oval-shaped male sex organs that sit inside the scrotum on either side of the penis. The testicles are an important part of the male reproductive system because they produce sperm and the hormone testosterone, which plays a major role in male sexual development. Types of testicular cancer The different types of testicular cancer are classified by the type of cells the cancer begins in. The most common type of testicular cancer is germ cell testicular cancer, which accounts for around 95% of all cases. Germ cells are a type of cell that the body uses to create sperm. There are 2 main subtypes of germ cell testicular cancer. They are: seminomas which have become more common in the last 20 years and now account for 50 to 55% of testicular cancers non-seminomaswhich account for most of the rest and include teratomas, embryonal carcinomas, choriocarcinomas and yolk sac tumours Both typestend to respond well to chemotherapy . Less common types of testicular cancer include: Leydig cell tumours which account for around 1 to 3% of cases Sertoli cell tumours which account for around 1% of cases lymphoma which accounts for around 4% of cases This topic focuses on germ cell testicular cancer. You can contact the cancer support specialists at Macmillan for more information about Leydig cell tumour and Sertoli cell tumours. Their helpline number is 0808 808 00 00 and its open Monday to Friday, 9am to 8pm. Read more about Hodgkin lymphoma and non-Hodgkin lymphoma . How common is testicular cancer? Testicular cancer is a relatively rare type of cancer. Testicular cancer is unusual compared to other cancers because it tends to affect younger men and anyone with testicles. Although its relatively uncommon overall, testicular cancer is the most common type of cancer to affect men and anyone with testicles between the ages of 15 and 49. For reasons that are unclear,white men and anyone with testicles have a higher risk of developing testicular cancer compared with other ethnic groups. The number of cases of testicular cancer that are diagnosed each year in the UK has roughly doubled since the mid-1970s. Again, the reasons for this are unclear. Causes of testicular cancer The exact cause or causes of testicular cancer are unknown, but a number of factors have been identified that increase a mans risk of developing it. The 3 main risk factors are described below. Undescended testicles Undescended testicles(cryptorchidism) is the most significant risk factor for testicular cancer. About 3to 5% of boys are born with their testicles inside their abdomen. They usually descend into the scrotum during the first year of life, but in some boys the testicles dont descend. In most cases, testiclesthat dont descend by the time a boy is 1 year old descendat a later stage. If the testicles dont descend naturally,an operation known as anorchidopexy can be carried out to move the testicles into the correct position inside the scrotum. Its important that undescended testicles move down into the scrotum during early childhood because boys with undescended testicles have a higher risk of developing testicular cancer than boyswhose testicles descend normally. Its also much easier to observe the testicles when theyre in the scrotum. People with undescended testicles are about 3 times more likely to develop testicular cancer than those whose testicles descend at birth or shortly after. Family history Having a close relative with a history of testicular cancer or an undescended testicle increases your risk of also developing it. For example, if your father had testicular cancer, youre around 4 times more likely to developit than someone with no family history of the condition. If your brother had testicular cancer, youre about 8 times more likely to develop it. A number of genes may be involvedin the development of testicular cancerin families where more than 1 person has had the condition. This is an ongoing area of researchin which patients and their families may be asked to take part. Previous testicular cancer People whove previously been diagnosed with testicular cancer are between 4 to 12 times more likely to develop it in the other testicle. For this reason,if youve previously been diagnosed with testicular cancer, its very important that you keep a close eye on the other testicle. If youve been diagnosed with testicular cancer, you also need to be observed for signs of recurrence for between 5 and 10 years, so its very important that you attend your follow-up appointments. Cancer Research UK has more information about testicular cancer risks and causes . Outlook Testicular cancer is one of the most treatable types of cancer, and the outlook is one of the best for cancers. Almost all men and anyone with testicles who are treated for testicular germ cell tumours are cured, and its rare for the condition to return more than 5 years later. Treatment almost always includes the surgical removal of the affected testicle  called orchidectomy or orchiectomy  which doesnt usually affect fertility or the ability to have sex. In some cases, chemotherapy or, less commonly, radiotherapy may be used for seminomas (but not non-seminomas). Read more about treating testicular cancer . Symptoms of testicular cancer The most common symptom of testicular cancer is a lump or swelling in 1 of your testicles. The lump or swelling can be about the size of a pea, but may be larger. Most lumps or swellings in the scrotum arent in the testicle and arent a sign of cancer. But they should never be ignored. Visit your GP as soon as you notice a lump or swelling in your scrotum. Associated symptoms Testicular cancer can also cause other symptoms, including a: dull ache or sharp pain in your testicles or scrotum, which may come and go feeling of heaviness in your scrotum change in the texture or increase in firmness of a testicle difference between one testicle and the other When to speak to your GP Speak to your GP as soon as you notice any lump or swelling on your testicle. Theyll examine your testicles to help determine whether or not the lump is cancerous. Lumps within the scrotum can have many different causes and testicular cancer is rare. If your GP thinks the lump is in your testicle they may consider cancer as a possible cause. Research has shown that less than 4% of scrotal lumps or swellings are cancerous. For example,varicoceles (swollen blood vessels) and epididymal cysts (cysts in the tubes around the testicle) are common causes of testicular lumps. If you do have testicular cancer, the sooner treatment begins, the greater the likelihood that youll be completely cured. If you dont feel comfortable visiting your GP, you can go to your local sexual health clinic , where a healthcare professional will be able to examine you. Metastatic cancer If testicular cancer has spread to other parts of your body, you may also experience other symptoms. Cancer that has spread to other parts of the body is known as metastatic cancer. Around 5% of people with testicular cancer will experience symptoms of metastatic cancer. The most common place for testicular cancer to spread to is nearby lymph nodes in your abdomen or lungs. Lymph nodes are glands that make up your immune system. Less commonly, the cancer can spread to your liver, brain or bones. Symptoms of metastatic testicular cancer can include: a persistent cough coughing or spitting up blood shortness of breath swelling and enlargement of male breasts alump or swelling in your neck lowerback pain Diagnosing testicular cancer Speak to your GP as soon as possible if you notice a lump or other abnormality in your scrotum that you think may be on one of your testicles. Most scrotal lumps arent cancerous, but if you have a lump that you think may be in one of your testicles its important you have it checked as soon as possible. Treatment for testicular cancer is much more effective when startedearly. Physical examination As well as asking you about your symptoms and looking at your medical history, your GP will usually need to examine your testicles. They may hold a small light or torch against your scrotum to see whether light passes through it. Testicular lumps tend to be solid, which means light is unable to pass through them. A collection of fluid in the scrotum will allow light to pass through it. Tests for testicular cancer If you have a non-painful lump, or a change in shape or texture of oneof your testicles, and yourGP thinks it may be cancerous, youll be referred for further testing within 2 weeks. Scrotal ultrasound A scrotal ultrasound s can is a painless procedure that uses high-frequency sound waves to produce an image of the inside of your testicle. Its one of the main ways of finding out whether or not a lump is cancerous (malignant) or non-cancerous (benign). During a scrotal ultrasound, your specialist will be able to determine the position and size of the abnormality in your testicle. It will also give a clear indication of whether the lump is in the testicle or separate within the scrotum, and whether its solid or filled with fluid. A fluid-filled lump or collection around the testisis usually harmless. A more solid lump may be a sign the swelling is cancerous. Blood tests To help confirm a diagnosis, you may need a series of blood tests to detect certain hormones in your blood, known as markers. Testicular cancer often produces these markers, so if theyre in your blood itmay indicate you have the condition. Markers in your blood that will be tested for include: AFP (alpha feta protein) HCG (human chorionic gonadotrophin) A third blood test is also often carried out as it may indicate how active a cancer is. Its calledLDH (lactate dehydrogenate), but it isnt a specific marker fortesticular cancer. Not all people with testicular cancer produce markers. There may still be a chance you have testicular cancer even if your blood test results come back normal. Histology The only way to definitively confirm testicular cancer is to examine part of the lump under a microscope. These tests and reports are called histology. Unlike many cancers where a small piece of the cancer can be removed (a biopsy ), in most cases the only way to examine a testicular lump is by removing theaffected testicle completely. This is because the combination of the ultrasound and blood marker tests is usually sufficient to makea firm diagnosis. Also, a biopsy may injure the testicle and spread cancer into the scrotum which isnt usually affected. Your specialist will only recommend removing your testicle if theyre relatively certain the lump is cancerous. Losing a testicle wont affect your sex life or ability to have children. The removal of a testicle is called an orchidectomy. Its the main type of treatment for testicular cancer, so if you have testicular cancer its likely youll need to have an orchidectomy. Other tests In almost all cases, youll need further tests to check whether testicular cancer has spread. When cancer of the testicle spreads, it most commonly affects the lymph nodes in the back of the abdomen or the lungs. Therefore, you may require a chest X-ray to check forsigns of a tumour. Youll also need a scan of your entire body. This is usually a CT scan (computerised X-ray) to check for signs of the cancer spreading. In some cases, a different type of scan, known as a magnetic resonance imaging (MRI) scan may be used. Stages of testicular cancer After all tests have been completed, its usually possible to determine the stage ofyour cancer. There are 2 ways that testicular cancer can be staged. The first is known as the TNM staging system: T  indicates the size of the tumour N  indicates whether the cancer has spread to nearby lymph nodes M  indicates whether the cancer has spread to other parts of the body (metastasis) Testicular cancer is also staged numerically. The 4 main stages are: stage 1  the cancer is contained within your testicle and epididymis (the tube at the back of the testicle) stage 2  the cancer has spread from the testicles into the lymph nodes (small glands that help fight infection) at the back of the abdomen stage 3  the cancer has spread to the lymph nodes in the middle of the chest or in the neck stage 4  the cancer has spread to the lungs or, rarely, to other tissues ororgans, such as the liver, bones or brain Cancer Research UK has more information about testicular cancer stages . Treating testicular cancer Chemotherapy, radiotherapy and surgery are the 3 main treatments for testicular cancer. Your recommended treatment plan will depend on: the type of testicular canceryou have  whether its aseminoma or a non-seminoma the stageof your testicular cancer The first treatment option for all cases of testicular cancer, whatever the stage, is to surgically remove the affected testicle (an orchidectomy). For stage 1 seminomas, after the testicle has been removed, a single dose of chemotherapy may be given to help prevent the cancer returning. A short course of radiotherapy is also sometimes recommended. However, in many cases, the chance of recurrence is low and your doctors may recommend that youre very carefully monitored over the next few years. Further treatment is usually only needed for the small number of people who have a recurrence. Forstage 1 non-seminomas, close follow-up (called surveillance) may also be recommended, or a short course of chemotherapy using a combination of different medications. For stage 2, 3 and 4 testicular cancers, 3 to 4 cycles of chemotherapy are given using a combination of different medications. Further surgery is sometimes needed after chemotherapy to remove any affected lymph nodes or deposits in the lungs or, rarely, in the liver. Some people with stage 2 seminomas may be suitable for less intense treatment with radiotherapy, sometimes with the addition of a simpler form ofchemotherapy. In non-seminoma germ cell tumours, additional surgery may also be required after chemotherapy to remove tumours from other parts of the body, depending on the extent of the spread of the tumour. Deciding what treatment is best for you can be difficult. Your cancer team will make recommendations, but the final decision will be yours. Before discussing your treatment options with yourspecialist,you may find it useful to write a list of questions to ask them. For example, you may want to find out the advantages and disadvantages of particular treatments. Orchidectomy An orchidectomy is a surgical procedure to remove a testicle. If you have testicular cancer, the whole of the affected testicle will need to be removed because only removing the tumour may lead to the cancer spreading. By removing the entire testicle, your chances of making a full recovery are greatly improved.Your sex life andability to father children wont be affected. About1 in 50 people will get a second new testicular cancer in their remaining testicle. In such circumstances, itssometimes possible to only remove the part of the testicle containing the tumour. You should ask your surgeon about this if youre in this position. If testicular cancer is detected in its very early stages, an orchidectomy may be the only treatment you require. An orchidectomy isnt carried out through the scrotum. Its done by making an incision in your groin through which the testicle isremoved with all of the tubes and blood vessels attached to the testicle that pass through the groin into the abdomen. The operation is carried out under general anaesthetic . You can have an artificial (prosthetic) testicle inserted into your scrotum so that the appearance of your testicles isnt greatly affected. The artificial testicle is usually made of silicone (a soft type of plastic).It probably wont be exactly like your old testicle or the one you still have. It may be slightly different in size or texture. Afteran orchidectomy, its often possible to be discharged quickly, although you may need to stay in hospital for a few days. If only 1 testicle is removed, there shouldnt be any lasting side effects. If both testicles are removed (a bi-lateral orchidectomy), youll be infertile. However, removing both testicles at the same time is very rarely required, and only 1 in every 50 cases require the other testicle to be removed at a later date. You may be able to bank your sperm before having a bi-lateral orchidectomy to allow you to father children if you decide to. Sperm banking Most people are still fertile after having 1 testicle removed. However, some treatments for testicular cancer can cause infertility. Some people with testicular cancer may have low sperm counts because of changes that occur in the testicles before the cancer develops. For some treatments, such as chemotherapy, infertility may occur, but standard chemotherapies have a less than 50% chance of causing infertility if the remaining testicle is normal. In people who need to have post-chemotherapy removal of lumps at the back of the abdomen, known as retroperitoneal lymph node dissection (RPLND), the ability to ejaculate (eject sperm from the penis) may be affected, even though the remaining testicle can still produce sperm. Before your treatment begins, you may want to consider sperm banking. This is where a sample of your sperm is frozen so that it can be used at a later date to impregnate your partner during artificial insemination. Before sperm banking, you may be asked to have tests for HIV , hepatitis B and hepatitis C . If youre having complex chemotherapy for stage 2 to 4 testicular cancer, you should always be offered sperm banking. Ask if youre concerned about your fertility. Not all men are suitable for sperm banking. For the technique to work, the sperm has to be of a reasonably high quality. There may also be situations where its considered too dangerous to delay treatment for sperm banking to take place. MostNHS cancer treatment centres offer a free sperm banking service. However, its up to each area of the country to decide whether they store sperm for free or whether you have to pay. Cancer Research UK has more information about sperm banking , including the cost of sperm storage. Testosterone replacement therapy If you still have a remaining testicle, in most cases (90%)your body will make enough testosterone so you wont notice any difference. If there are any problems with your remaining testicle, you may experience symptoms due to a lack of testosterone. These symptoms can be caused for other reasons but can include: tiredness weight gain loss of libido (sex drive) reduced beard growth reduced ability to achieve or maintain an erection ( erectile dysfunction ) Having both testicles removed will definitely stop you producing testosterone and youll develop the above symptoms. Testosterone replacement therapy is where youre given testosterone in the form of an injection, skin patch or gel to rub into your skin. If you have injections, youll usually need to have them every 2 to 3 months. After having testosterone replacement therapy, youll be able to maintain an erection and your sex drive will improve. Side effects associated with this type of treatment are uncommon, and any side effects that you do experience will usually be mild. They may include: oily skin, which can sometimes trigger the onset of acne breast enlargement and swelling a change innormal urinary patterns, such as needing to urinate more frequently or having problems passing urine (caused by an enlarged prostate gland that puts pressure on your bladder) There are also concerns that testosterone replacement may increase the risk of prostate cancer and you should discuss this with your doctor. However, the risks from having testosterone replacement are usually much lower than the benefits of receiving it. Lymph node and lung surgery More advanced cases of testicular cancer may spread to your lymph nodes. Lymph nodes are part of your bodys immune system, which helps protect against illness and infection. Lymph node surgery is carried out under general anaesthetic. The lymph nodes in your abdomen are the nodes most likely to need removing. In some cases, the nerves near the lymph nodes can become damaged, which means that rather than ejaculating semen out of your penis during sex or masturbation, the semen instead travels back into your bladder. This is known as retrograde ejaculation. If you have retrograde ejaculation, youll still experience the sensation of having an orgasm during ejaculation, but you wont be able to father a child. There are a number of ways of treating retrograde ejaculation, including the use of medicines that strengthen the muscles around the neck of the bladder to prevent the flow of semen into the bladder. Men and anyone with testicles who wants to have children can have sperm taken from their urine for use inartificial insemination or in-vitro fertilisation (IVF). There are also a number ofnewer surgical techniques that carry a lower risk of retrograde ejaculation and infertility. Some people with testicular cancer have deposits of cancer in their lungs and these may also need to be removed after chemotherapy if they havent disappeared or reduced sufficiently in size. This type of surgery is also carried out under general anaesthetic and doesnt usually significantly affect breathing in the long-term. Nerve-sparing retroperitoneal lymph node dissection A newer type of lymph node surgery, called nerve sparing retroperitoneal lymph node dissection (RPLND), is increasingly being used because it carries a lower risk of causing retrograde ejaculation and infertility. In nerve-sparing RPLND, the site of the operation is limited to a much smaller area. This means theres less chance of nerve damage occurring. The disadvantage is that the surgery is more technically demanding. Therefore, nerve-sparing RPLND is currently only available at specialist centres that employ surgeons with the required training. Laparoscopic retroperitoneal lymph node dissection Laparoscopic retroperitoneal lymph node dissection (LRPLND) is a type of keyhole surgery that can be used to remove the lymph nodes. During LRPLND, the surgeon will make a number of small incisions in your abdomen. An instrument called an endoscope is inserted into one of the incisions. An endoscope is a thin, long, flexible tube with a light and a camera at one end, enabling images of the inside of your body to be relayed to an external television monitor. Small, surgical instruments are passed down the endoscope and can be used to remove the affected lymph nodes. The advantage of LRPLND is that theres less post-operative pain and a quicker recovery time. Also, as with nerve-sparing RPLND, in LRPLND theres a smaller chance that nerve damage will lead to retrograde ejaculation. However, as LRPLND is a new technique, theres little available evidence regarding the procedures long-term safety and effectiveness. If youre consideringLRPLND, you should understand there are still uncertainties about the safety and effectiveness ofthe procedure. Radiotherapy Radiotherapy uses high-energy beams of radiation to help destroy cancer cells. Sometimes, seminomas may require radiotherapy after surgery to help prevent the cancer returning. It may also be needed in advanced cases where someone is unable to tolerate the complex chemotherapies that are usually used to treat stage 2, 3 and 4 testicular cancer. If testicular cancer has spread to your lymph nodes, you may require radiotherapy after a course of chemotherapy. Side effects of radiotherapy can include: reddening and soreness of the skin, which is similar to sunburn nausea diarrhoea fatigue These side effects are usually only temporary and should improve when your treatment is completed. Chemotherapy Chemotherapy uses powerful medicines to kill the malignant (cancerous) cells in your body or stop them multiplying. You may require chemotherapy ifyou have advanced testicular cancer or its spread within your body. Its also used to help prevent the cancer returning. Chemotherapy is commonly used to treat seminomas and non-seminoma tumours. Chemotherapy medicines for testicular cancer are usually injected into a vein. In some cases, a special tube called a central line is used, which stays in a vein throughout your treatment so that you dont have to keep having blood tests or needles placed in a new vein. Sometimes, chemotherapy medicines can attack your bodys normal, healthy cells. This is why chemotherapy can have many different side effects. The most commoninclude: vomiting hair loss nausea sore mouth and mouth ulcers loss of appetite fatigue breathlessness and lung damage infertility ringing in your ears ( tinnitus ) skin that bleeds or bruises easily low blood counts increased vulnerability to infection numbness and tingling (pins and needles) in your hands and feet kidney damage These side effects are usually only temporary and should improve after youve completed your treatment. Side effects, such as infections that occur when you have a low blood count, can be life-threatening, and its essential that you always call your cancer care team if youre worried between chemotherapy treatments. Bleomycin One of the medicines commonly used, called bleomycin, can cause long-term lung damage and you should discuss this with your doctors if damage to your lungs would have specific issues for your career or lifestyle. However, the advice may still be that you should receive it for the best chance of a cure. Having children You shouldnt father children while having chemotherapy and for a year after your treatment has finished. This is because chemotherapy medications can temporarily damage your sperm, increasing your risk of fathering a baby with serious birth defects. Therefore, youll need to use a reliable method of contraception , such as a condom , during this time. Condoms should also be used during the first 48 hours after having a course of chemotherapy. This is to protect your partner from any potentially harmful effects of the chemotherapy medication in your sperm. Read more about the side effects of chemotherapy . Follow-up Even if your cancer has been completely cured, theres a risk it will return.The risk of your cancer returning will depend on what stage it was atwhen you were diagnosed and what treatment youve had since. Most recurrences of non-seminoma testicular cancer occur within 2 years of surgery or completion of chemotherapy. In seminomas, recurrences still occur until 3 years. Recurrences after 3 years are rare, occurring in less than 5% of people. Because of the risk of recurrence, youll need regular tests to check if the cancer has returned. These include: a physical examination blood tests to check for tumour markers a chest X-ray a computerised tomography (CT) scan Follow-up and testing is usually recommended dependingon the extent of the cancer and the treatment offered. This is usually more frequent in the first year or two but follow-up appointments may last for up to 5 years. In certain cases, it may be necessary to continue follow-up appointments for 10 years or longer. If the cancer returns following treatment for stage 1 testicular cancer, and its diagnosed at an early stage, it will usually be possible to cure it using chemotherapy and possibly also radiotherapy. Some types of recurring testicular cancer have a cure rate of over 95%. Recurrences that occur after previous combination chemotherapy can also be cured, but the chances of this will vary between individuals and youll need to ask your doctors to discuss this with you. Cancer Research UK hasmore information about follow-up for testicular cancer. Causes of testicular cancer The causes of testicular cancer are not fully understood. However, several things that increase yourrisk of developing the condition. Undescended testicles Undescended testicles is the most significant risk factor. When male babies grow in the womb, their testicles develop inside their abdomen. The testicles then normally move down into the scrotum when the baby is born or during their first year of life. However, for some children, the testicles fail to descend. The medical name forundescended testicles is cryptorchidism. Surgery is usually required to move the testicles down. If you have had surgery to move your testicles down into your scrotum, your risk of developing testicular cancer may be increased. Of surgery is performed before the child is 13 years of age, their risk of later developing testicular cancer is approximately double that of the rest of the population. However, if the operation is carried out after the boy is 13 years of age, the risk of developing testicular cancer is 5 times greaterthan that ofthe rest of the population. Previous testicular cancer Men and anyone with testicles who has previously been diagnosed with testicular cancer are 12 times more likely to develop testicular cancer in the other testicle. For this reason, its important to attend follow-up appointments if you have previously been diagnosed with testicular cancer. Age and race Unlike most other types of cancer, testicular cancer is more common in young and middle-aged men and anyone with testicles. Men and anyone with testicles aged 30to 34 are most likely to be diagnosed with testicular cancer. Testicular cancer is more common in white men and anyone with testicles than other ethnic groups. Its also more common in Northern and Western Europe compared with other parts of the world. Family history Having a close relative with a history of testicular cancer increases your risk of developing it. If your father had testicular cancer, you are 4 to 6 times more likely to developit thana person with no family history of the condition. If your brother had testicular cancer, you are 8 to 10 times more likely to develop it (having an identical twin with testicular cancer means that you are 75 times more likely to develop it). The fact that testicular cancer appears to run in families has led researchers to speculate that there may be one or more genetic mutations (abnormal changes to the instructions that control cell activity) that make a person more likely to develop testicular cancer. Mutations in 2 genes (known as the KITLG and SPRY4 genes) mayincrease the risk of a person developing testicular cancer. Endocrine disruptors Examples of endocrine disruptors include: some types of pesticide polychlorinated biphenyls (PCBs), chemical compounds used as a coolant dibutyl phthalate, a chemical used to manufacture cosmetics, such as nail polish In most countries, including the UK, many endocrine disruptors, such as PCBs, have been withdrawn as a result of their link to health problems. However, there is a concern that exposure to endocrine disruptors may still occur due to contamination of the food chain. However, there is not yet enough evidence to prove a definite link between indirect exposure to low levels of endocrine disruptors and health problems. Indirect exposure is the type of exposure that would occur if the food chain was contaminated. Infertility Men and anyone with testicles who are infertileare 3 times more likely to develop testicular cancer. The reasons for this are not clear. Smoking Research has found that long-term smokers (people who have been smoking a pack of 20 cigarettes a day for 12 years or 10 cigarettes a day for 24 years) are twice as likely to develop testicular cancerthan non-smokers. HIV and AIDS Studies show that men and anyone with testicles with HIV or AIDS have an increased risk of testicular cancer. Source: NHS 24 - Opens in new browser window Last updated: 14 November 2023 How can we improve this page? Help us improve NHS in