Samantha912/NLP_A2_WTH huggingface dataset:
Klebsazolicin (KLB) is a peptide antibiotic encoded in the genome of a gram-negative bacterium Klebsiella pneumoniae subsp.  and targeting prokaryotic ribosome. Klebsazolicin is a ribosomally synthesized and post-translationally modified peptide (RiPP) and a linear -containing peptide (LAP).

Discovery 
The discovery of KLB represents an example of a “genome mining” approach. Cluster of genes encoding KLB biosynthetic pathway was found in genome database using low-level homology of one of the proteins to microcin B17 synthetase. Cloning and expression of cluster in a heterologous host (Escherichia coli) yielded the active compound. The name given to the compound reflects the original bacterium where the biosynthetic cluster was found (Klebs-) and the presence of azole cycles (-azolicin).

Structure 
The structure of KLB was established by a combination of mass-spectrometry and NMR methods. Klebsazolicin is 23-aminoacid long peptide, containing four azoles (3 thiazoles and an oxazole) and an N-terminal lactamidine ring. The latter is formed by a linkage between two N-terminal amino acids (serine and glutamine) and is absolutely essential for bioactivity.

Activity 
Klebsazolicin is active against Gram-negative bacteria closely related to Klebsiella, such as Escherichia coli, Klebsiella pneumoniae, and Yersinia pseudotuberculosis. KLB inhibits protein synthesis on the prokaryotic ribosome by binding to and blocking peptide exit tunnel and thus preventing the passage of the nascent peptide. The activity of KlpE export pump encoded in KLB biosynthetic gene cluster confers self-resistance of the producing bacterium to the action of the antibiotic.

Biosynthesis 
Typically to other RiPPs, klebsazolicin is produced in three steps. At the first step, a 47-aa precursor peptide KlpA is synthesized using cellular translation machinery. Then an N-terminal leader peptide serves as a recognition element for KlpBCD, a heterocyclase-dehydrogenase complex which converts serine and cysteine residues of KlpA into oxazole and thiazole heterocycles. Finally, the leader is cleaved off by the action of cellular proteases such as TldD/E, and at the same time KlpBCD activates the new N-terminus to form lactamidine. Thus, KlpBCD is able to introduce both azole heterocycles and lactamidine linkages, using side chains of Ser/Cys residues and N-terminal amino group as nucleophiles.

References 

Antimicrobial peptides
Antibiotics
The Akron Marathon is a marathon located in Akron, Ohio. It is typically held in September.

The race was first run in 2003. It played host to the North American Men's Marathon Relay Championships in its first two years. The 2021 event will take place on September 25 with the marathon, half marathon, and marathon team relay. The race routes have changed several times since its beginning, and is generally considered a challenging course through Akron's scenic neighborhoods.

List of winners

Men

Women's 

Full results for each year are available from Marathon Guide.

See also
 List of marathon races in North America

References

External links
 

Marathons in the United States
Recurring sporting events established in 2003
Annual sporting events in the United States
September sporting events
Sports in Akron, Ohio
Tropospheric Emission Spectrometer or TES was a satellite instrument designed to measure the state of the earth's troposphere.

Overview
TES was a high-resolution infrared Fourier Transform spectrometer and provided key data for studying tropospheric chemistry, troposphere-biosphere interaction, and troposphere-stratosphere exchanges. It was built for NASA by the Jet Propulsion Laboratory, California Institute of Technology in Pasadena, California. It was successfully launched into polar orbit by a Delta II 7920-10L rocket aboard NASA's third Earth Observing Systems spacecraft (EOS-Aura) at 10:02 UTC on July 15, 2004. Originally planned as a 5-year mission, it was decommissioned after almost 14 years on January 31, 2018.

References

External links
 NASA JPL's TES page
 NASA Aura TES page

Spectrometers
Earth observation satellite sensors
Gund is a manufacturer of plush stuffed toys, one of the first manufactures of Teddy bears .

Gund or gunde may also refer to:

People
Agnes Gund, President Emerita of the Museum of Modern Art and member of the Board of Trustees of the National Council on the Arts
Gordon Gund, CEO of Gund Investment Corporation and the owner of various U.S. sports teams  
Graham Gund, president and founder of Gund Partnership, an architecture firm based in Cambridge, Massachusetts
Gunde Svan, a former Swedish cross country skier and auto racing driver

Other
Gund Institute for Ecological Economics, an environmental institute housed at the University of Vermont
Gund, the historical name of the Indian village of Kanihama

See also
Gundi (disambiguation)
Gundy (disambiguation)
The red-nosed mouse (Wiedomys pyrrhorhinos) is an arboreal rodent species endemic to Brazil. It is found in caatinga and cerrado habitat in southeast Brazil.

References

Wiedomys
Mammals of Brazil
Endemic fauna of Brazil
Taxa named by Prince Maximilian of Wied-Neuwied
Mammals described in 1821
The Long Weekend EP in an EP released by Barenaked Ladies on July 1, 2014. It was released in Canada, though a deluxe edition of Grinning Streak was released in the U.S., containing acoustic versions of "Odds Are", "Smile" and "Blame It On Me". The live version of "Did I Say That Out Loud?" was not included on the U.S. version.

Recording
The acoustic tracks were recorded in March 2014 at bassist Jim Creeggan's home in Toronto. The band posted weekly "Webisodes", including behind-the-scenes footage of the recording sessions for the EP on their official YouTube channel. The EP was produced by Barenaked Ladies, mixed and engineered by Kenny Luong and mastered by Harry Hess at HBomb Mastering.

Track listing

References

2014 EPs
Barenaked Ladies EPs
Isabella, Isabel, Elizabeth or Elisabeth of Portugal may refer to:

 Elizabeth of Portugal (1271–1336), saint, queen consort of Portugal
 Isabella of Portugal, Lady of Viseu (1364–1395), natural daughter of King Ferdinand I of Portugal
 Isabella of Portugal, Duchess of Burgundy (1397–1471), daughter of King John I of Portugal and third wife of Philip the Good
 Isabella of Coimbra (1432–1455), queen consort of Portugal
 Isabella of Barcelos (1414–1476), also known as Isabella of Braganza, daughter of Afonso I, Duke of Braganza, wife of Infante John, Constable of Portugal
 Isabella of Portugal, Queen of Castile (1428-1496)
 Isabella of Viseu (1459–1521)
 Isabella, Princess of Asturias (1470–1498), queen consort of Portugal
 Isabella of Portugal (1503–1539). Regent of Spain. Infanta of Portugal. Holy Roman Empress, German Queen and Queen consort of Spain.
 Isabella of Braganza, Duchess of Guimarães (1514–1576), daughter of Jaime I, Duke of Braganza, wife of Infante Edward, 4th Duke of Guimarães
 Infanta Isabella Clara Eugenia of Spain (1566–1633), infanta of Portugal
 Isabel Luísa, Princess of Beira (1668–1690), infanta of Portugal
 Maria Isabel of Braganza (1797–1818), infanta of Portugal, consort Queen of Spain 
 Infanta Isabel Maria of Portugal (1801–1876), infanta of Portugal
 Isabel, Princess Imperial of Brazil (1846–1921)
 Isabel, Duchess of Braganza

See also
Isabella of Braganza (disambiguation)
Umbra is a sans-serif display typeface designed in 1935 by R. Hunter Middleton for the Ludlow Typograph company.  It is an adaptation of the uppercase light weight of his earlier typeface Tempo. The name Umbra refers to its shadow effect, in which the actual letter shape consists of negative space and is defined solely by its black dimensional shadow. Several other typefaces were created in similar style around the same time, including shadowed weights of Gill Sans. Nebiolo's Ombra, part of their Semplicità family, is very similar.

Umbra has been digitised.

References

Display typefaces
Typefaces and fonts introduced in 1935
Letterpress typefaces
Typefaces designed by R. Hunter Middleton
Geometric sans-serif typefaces
Richard Kevin James Dawson (born 4 August 1980, Doncaster, Yorkshire, England) is an English cricket coach and former first-class cricketer, who played primarily as an off-spinner.

Playing career 
Born 4 August 1980, Doncaster, Yorkshire, Dawson attended Batley Grammar School and Exeter University. He played for the England Under-19 side against New Zealand in 1998/99 and Australia in 1999, and made his first-class debut for British Universities against the touring Zimbabweans the following summer. He first appeared for Yorkshire in 2001.

He made his Test match debut against India in 2001/02, and filled in for the injured Ashley Giles during the following winter's Ashes series. He bowled the ball in which Steve Waugh hit his famous last ball of the day century in the 2002/03.

In the 2006 season, Dawson captained the Yorkshire 2nd XI but at the end of that season he was released from his contract with Yorkshire. He was signed by Northamptonshire to provide cover for their England spinner Monty Panesar.

Dawson was released by Northamptonshire at the end of the 2007 season, and began training as a journalist in September 2007. However, in the 2008 English cricket season, he once again returned to English county cricket, this time with Gloucestershire. He was not a regular choice as a player but also held the role of spin coach.

Coaching career 

In February 2014 Dawson was appointed as the Second XI coach of Yorkshire County Cricket Club to replace the departing Paul Farbrace.

On 30 January 2015, Dawson was appointed the new head coach of Gloucestershire County Cricket Club following the departure of director of cricket John Bracewell.

In December 2019 Dawson was named as the coach for the England Lions' eight-match tour of Australia, due to take place in February and March 2020.

References

1980 births
Living people
Cricketers from Doncaster
Alumni of the University of Exeter
England Test cricketers
English cricketers
Devon cricketers
Yorkshire cricketers
Marylebone Cricket Club cricketers
Northamptonshire cricketers
Gloucestershire cricketers
English cricket coaches
British Universities cricketers
English cricketers of 1969 to 2000
English cricketers of the 21st century
The Newburyport Silver Company was an American silversmithing company, active from 1904 to 1914 in Keene, New Hampshire. It was founded in 1902 by 7 men in Newburyport, Massachusetts. In 1904 production moved to Keene and by 1908 the firm employed about 40 craftsmen and a dozen salesman. It produced sterling silver products, such as flatware and candlesticks, for New England and national markets, but ceased operation in 1915.

References 
 "Newburyport Silver Company", Historical Society of Cheshire County.
 Keene: Drawn from the Collections of the Historical Society of Cheshire County, Keene, New Hampshire, Alan F. Rumrill, Arcadia Publishing, 1995, page 37.
 Public Documents of Massachusetts: Being the Annual Reports of Various Public Officers and Institutions ..., Volume 2, State Printers, 1904, page 181.
 "Newburyport Silver Company", Certificate Collector.
 Online Encyclopedia of Silver Marks, Hallmarks, and Makers' Marks
 "Newburyport Silver Company", American Sterling Silver Marks.

American silversmiths
Steirisches Vulkanland () is an extinct volcanic field located in the Austrian state of Styria which maintained activity between 15 ma–2 ma ago, its last activity being in the Gleichenberg Kögel in Burgenland, currently the remnants of this volcanic field are the Hills, Maars and Diatremes.

Origin and History  

The origin of the volcanic activity began during the collision of the African and Eurasian plates, the formation of the Styrian basin and the simultaneous filling of part of the associated Paratethys sea began about 18 ma, in that period the volcanic activity would begin due to the system of faults and would be at its apogee 15 ma ago, the volcanic peaks protruded from the paratethys sea while the sea was inhabited by different marine species, the sea was shallow, around 13 ma ago and would begin to dry slowly and around 11 ma the land would become more swampy, with small lakes and trees where now quadrupeds and birds would inhabit at the same time the volcanic activity would also be extinguished even though the expulsions of lava and ash would continue, although the activity would continue in volcanoes such as Pauliberg and Gleichenberg Kögel, around 5 ma the region would have already dried up and the uplift phase of the basin and the erosion of the rock mass would begin, the last The last volcanic phase would begin in the Pleistocene during the ice age, the fauna would dry up and be covered under snow, the activity would decrease considerably and only the volcanoes would release slag and gas-rich explosions including lava flows, there would also be violent explosions due to contact of the water with the volcanic diatreme, after this the stage would end until 2 million years ago with the last eruption of the Gleichenberg Kögel volcano.

Tourism 

Steirisches Vulkanland is a region visited in Styria for its importance wine and forests, also for the crafts that are made as well as gastronomy, also where cycling and camping are experienced.

References

External links 

 Steirisches Vulkanland
 Vulkanland Karteninformationssystem
 Auf den Spuren der Vulkane

Volcanic fields
Landforms of Styria
Tourist attractions in Styria
Miocene volcanoes
Pleistocene volcanoes
Volcanoes of Austria
The Kırka mine is a large boron ore mine located at Eskişehir Province in western Turkey. Kırka represents one of the largest boron reserves in Turkey having an estimated reserve of 750.6 million tonnes of ore grading 28% boron.

References 

Boron mines in Turkey
Eskişehir Province
Seyitgazi District
The Slat al-Azama Synagogue or Lazama Synagogue (, ) is one of the best-known synagogues in Marrakesh, Morocco. It is located in the historic Mellah (Jewish quarter) of the old city.

History 
The synagogue was associated with Sephardic Jews who were expelled from Spain in 1492 (known as the Megorashim). The synagogue's foundation is likewise traditionally attributed to 1492, though one scholar has indicated that the exact year of establishment has not been verified. The Mellah district in which the synagogue is located was not created until 1557. In any case, the synagogue's current form dates from a more modern restoration. The building is still functioning as a synagogue today.

Architecture 
The synagogue is integrated into a larger building which consisted of a private house with a central courtyard (popularly referred to as a riad). This integration of a synagogue into a private home was typical of most synagogues in the Mellah of Marrakesh as well as in the Mellah of Fez. The synagogue itself has traditional Moroccan decoration such as zellij (mosaic tilework).

The east side was renovated after the 1950s, with the addition of a wing for women (ezrat nashim), which is unique in Morocco where tradition dictates that women stay in a separate room at the entrance of the synagogue. The original wooden Torah ark has been replaced by a marble ark, which is located next to the eastern wall. Notes drawn in the 1950s by architect Yaacov Finkerfeld demonstrate that the space mentioned above did not exist for women and that the interior was divided into two naves by four columns. On the upper floor there is a yeshiva.

References 

Jews and Judaism in Marrakesh
Buildings and structures in Marrakesh
Sephardi synagogues
Spanish diaspora in Africa
Spanish-Jewish diaspora
Synagogues in Morocco
Arthur Ernest Watson (29 February 1880 – 18 September 1969) was a British newspaper editor, known for editing The Daily Telegraph from 1924 to 1950.

Biography 
Watson was born in Newcastle upon Tyne on 29 February 1880, the second son of Aaron Watson, author and journalist, and his wife, Phebe. He attended Alleyn's School in Dulwich, Rutherford College of Technology in Newcastle, and Armstrong College of the University of Durham, before entering journalism. After a spell with the Newcastle Daily Leader, he joined  The Daily Telegraph in 1902. He was with the newspaper for the remainder of his career, although he served during World War I as an acting Major in the Royal Field Artillery. He became the Telegraph's Assistant Editor in 1923, and was appointed Editor the following year, serving until 1950. He was also active in the Institute of Journalists, and in retirement was the President of the Mitcham and Morden Conservative Association.

References

1880 births
1969 deaths
People educated at Alleyn's School
Alumni of Northumbria University
British Army personnel of World War I
British newspaper editors
Writers from Newcastle upon Tyne
Royal Field Artillery officers
The Daily Telegraph people
Alumni of Armstrong College, Durham
20th-century English businesspeople
Pseudis fusca is a species of frog in the family Hylidae. It is endemic to Minas Gerais, Brazil, and only known few localities. Although it is currently considered a valid species, it has also been treated as a subspecies of Pseudis paradoxa.

Description
Adult males measure  and adult females  in snout–vent length. The overall appearance is robust. The head is wider than it is long and the snout is rounded. The tympanum is distinct, elliptical in shape. The eyes are big. The toes are fully webbed. Skin is smooth. Preserved specimens are dorsally brown or grey, with darker markings that do not form any regular pattern.

Habitat and conservation
This aquatic frog occurs in permanent ponds and still-water pools of slow moving streams near larger rivers at an elevation of about  above sea level. It can also occur in large water reservoirs. Breeding takes place in pools and streams. It is a locally common species that can suffer from habitat loss caused by agricultural encroachment, infrastructure development, and agricultural pollution. Its presence in protected areas is unknown.

References

fusca
Amphibians of Brazil
Endemic fauna of Brazil
Taxa named by Samuel Garman
Amphibians described in 1883
Taxonomy articles created by Polbot
GTW may refer to:

Transportation
 Holešov Airport, in Zlín Region, Czech Republic

Rail transport
 Grand Trunk Western Railroad, an American railway
 Stadler GTW, an articulated railcar
 Gatwick Airport railway station, a railway station in Sussex, England

Road transport
 Gross trailer weight rating
 Gross train weight

Other uses
 GTW (TV station), in Western Australia
 Gateway, Inc., an American computer maker
 Geosciences Technology Workshop
 Global Trade Watch, an American consumer advocacy organization
Animals with Human Intelligence is the third studio album by the America rock band Enuff Z'nuff and is also their first and only album on Arista Records. Original drummer Vikki Foxx left Enuff Z'nuff right after the recording sessions ended, to join Vince Neil's band. In addition to the promotional video for the song "Right by Your Side," the band made a live appearance on the Late Night with David Letterman TV show, performing the song "Superstitious". The song "Innocence" was released as a follow-up single, though no video was made to promote it.

This record was not as successful as their prior releases in the US, but the band did find some success overseas. Singer Donnie Vie and bassist Chip Z'Nuff did a promotional tour of Japan, where the album peaked at No. 49 on the Oricon Charts. The Japanese issue of the album also included the exclusive track "Fingertips". The album was later re-issued in 2000 on Spitfire Records with new artwork and "Fingertips" now included.

In 1996, the song "Bring It On Home" was featured in the movie Jerry Maguire, starring Tom Cruise. However, the song only appears listed on the credits and was not in the actual film, since it was in a deleted scene. The song "Rock N World" was featured in the 2011 direct-to-video film Dahmer vs. Gacy.

The song "Right by Your Side" was covered by the Norwegian rock group The Tuesdays in 1994. The same song was also covered in 2009 on G.O.O.D. Morning, G.O.O.D. Night by Malik Yusef, a Kanye West collaboration album. Yusef's version of the song also features Destiny's Child singer Michelle Williams on backing vocals.

Track listing
All songs written by Donnie Vie and Chip Z'Nuff, except where noted.
"Superstitious" (Vie, Z'Nuff, Gino Martino) – 4:07
"Black Rain" – 3:48
"Right by Your Side" (Vie) – 4:22
"These Daze" – 3:51
"Master of Pain" – 4:25
"Innocence" (Vie) – 4:50
"One Step Closer to You" – 3:37
"Bring It On Home" – 3:55
"Takin' a Ride" – 4:11
"The Love Train" – 3:47
"Mary Anne Lost Her Baby" – 4:04
"Rock N World" – 3:21

Japanese and reissue editions bonus track
"Fingertips" – 3:50

Personnel
Enuff Z'nuff
Donnie Vie – lead vocals, guitar, piano, producer
Derek Frigo – lead guitar
Chip Z'Nuff – bass guitar, backing vocals, producer
Vikki Foxx – drums

Additional musicians
Brian Ripp, Jon Negus, Leo Kawczinski, Mark Colby, Steve Eisen, Steve Zoloto – saxophones on tracks 1 and 5
Gary Fry – brass arrangements
John Armstrong, Phil Kaffel – keyboard programming on track 2
Kim Bullard – keyboard arrangements

Production
Richie Zito – producer
Phil Bonanno – producer on tracks 1, 2, 5, 8-12, engineer
Dave Mauragas – engineer, assistant producer and additional engineering on track 6
Lawrence Ethan, Bruce Breckenfeld – engineers
Brian Scheuble, Chad Munsey, Doug McBride, Ulrich Wild – assistant engineers
Nigel Green – mixing at Battery Studios, New York
Eric Gast – mixing assistant
George Marino – mastering at Sterling Sound, New York

Release history

References 

1993 albums
Arista Records albums
Enuff Z'nuff albums
Albums produced by Richie Zito
Albums recorded at A&M Studios