Samantha912/NLP_A2_WTH huggingface dataset:
Anna Marie Pyle is an American academic who is a Sterling Professor of Molecular, Cellular & Developmental Biology and a Professor of Chemistry at Yale University.  and an Investigator for Howard Hughes Medical Institute. Pyle is the president of the RNA Society, the vice-chair of the Science and Technology Steering Committee at Brookhaven National Laboratory, and previously she served as chair of the Macromolecular Structure and Function A Study Section at the National Institutes of Health.

Early life and education 
Pyle grew up in Albuquerque, New Mexico, and it was there that she first became interested in science. But it wasn't until after earning her bachelor's degree from Princeton University that she committed to a career in chemistry. In 1990, she graduated from Columbia University with a Ph.D. in chemistry. Pyle went on to postdoc at the University of Colorado until in 1992 she established a research group at Columbia University Medical Center in the Department of Biochemistry and Molecular Biophysics. In 2002, she moved to Yale University.

Research 
Pyle joined Yale University in 2002. She researches the architectural features of large RNA molecules and RNA remodeling enzymes using experimental biochemistry and crystallography. such as self-splicing introns and other noncoding RNAs. She has focused her research to understand how large RNAs assemble into specific, stable tertiary structures, and also how ATP-dependent enzymes in the cell recognize and remodel RNA. Specifically, she was successful in crystallizing and solving the structure of a group IIC intron from the bacterium Oceanobacillus iheyensis and moves through the stages of splicing. Pyle's research may be helpful in drug development as RNA's tertiary structure could provide insight into druggable biomolecules.

Selected awards and honors 

 2023 Elected member of the U.S. National Academy of Sciences
 2018 Appointed as Sterling Professor of Molecular, Cellular, and Developmental Biology
 2007 Elected American Association for the Advancement of Science (AAAS) Fellow
 2005 Appointed member of the American Academy of Arts and Sciences

References 

Living people
Yale University faculty
Yale Sterling Professors
Princeton University alumni
American women biologists
American women biochemists
Howard Hughes Medical Investigators
Year of birth missing (living people)
People from Albuquerque, New Mexico
Columbia Graduate School of Arts and Sciences alumni
University of Colorado Boulder alumni
Place of birth missing (living people)
Fellows of the American Association for the Advancement of Science
Fellows of the American Academy of Arts and Sciences
American women academics
21st-century American women
The Upper Adams School District is a small, rural public school district serving parts of Adams County, Pennsylvania, including the boroughs of Bendersville, Biglerville, Arendtsville. It also serves the residents of Tyrone Township, Butler Township, and Menallen Township. Upper Adams School District encompasses approximately . By 2010, the district's population rose to 10,836 people. According to 2000 federal census data, it served a resident population of 9,693. In 2009, the district residents' per capita income was $17,278, while the median family income was $44,835. and the United States median family income was $49,445, in 2010. By 2013, the median household income in the United States rose to $52,100.

Upper Adams School District operates: Biglerville Elementary School (K–3), Upper Adams Intermediate School (4–6), Upper Adams Middle School (7–8), and Biglerville High School (9–12). High school students may choose to attend Cumberland Perry Vocational Technical School for vocational training. The Lincoln Intermediate Unit IU12 provides the district with a wide variety of services like specialized education for disabled students and hearing, speech and visual disability services and professional development for staff and faculty.

Extracurriculars
The district offers a variety of clubs, activities and sports.
The district funds:

Varsity

Boys
Baseball - AA
Basketball- AA
Cross country - A
Football - AA
Soccer - A
Tennis - AA
Track and field - AA
Wrestling - AA

Girls
Basketball - AA
Cross country - AA
Field hockey - AA
Soccer (fall) - AA
Softball - AA
Girls' tennis - AA
Track and field - AA

Middle school sports

Boys
Basketball
Football
Soccer
Track and field
Wrestling	

Girls
Basketball
Field hockey
Soccer (fall)
Track and field

According to PIAA directory July 2013

References

Education in Harrisburg, Pennsylvania
School districts in Adams County, Pennsylvania
Brady McKay Smith (born June 5, 1973) is a former American football defensive end in the National Football League. He was drafted by the New Orleans Saints in the third round of the 1996 NFL Draft. He played college football at Colorado State.

Smith also played for the Atlanta Falcons.

Professional career

New Orleans Saints
Smith was drafted by the New Orleans Saints in the third round of the 1996 NFL Draft. He played for them from 1996 to 1999. During the four years he started 27 of 62 games, recording 91 tackles and 13 sacks.

Atlanta Falcons
Smith signed with the Atlanta Falcons before the 2000 season. He played for the team from 2000 to 2005. In the six years he started 78 of 81 games, recording 169 tackles, 32 sacks and an interception. He announced his retirement in 2006.

NFL Stats

References

American football defensive ends
Colorado State Rams football players
New Orleans Saints players
Atlanta Falcons players
1973 births
Living people
Nachoragan was a commander in the military of the Sasanian Empire recorded in the Lazic War by the Byzantine historians. He succeeded Mihr-Mihroe as the commander of the operations in Lazica after the latter's death. As he took the command, the political situation favored the Sasanians, as the assassination of the Lazic king Gubazes by Byzantine generals had alienated the Lazi. Nachoragan relieved the Siege of Onoguris and subsequently destroyed the Byzantine base at Archaeopolis. In the spring of 556 AD, Nachoragan began a new invasion by attacking Nesus with 60,000 men, where Martin and Justin were positioned. After the rejection of his peace proposals by Martin, Nachoragan besieged Phasis, but was heavily defeated. He then retreated to Kutais, left the command of the Sasanians in Lazica to his subordinate Vaphrizes shortly after, and retired to winter quarters in Iberia.

The Greek name Nachoragan () recorded by the Byzantine historians probably represents not a name but the Middle Persian title naxwaragān or naxwāragān. It corresponds to the Syriac nkwrgn (, "governor") and the Armenian title nakharar, both of which are borrowed from Middle Iranian languages.

References

6th-century Iranian people
Generals of Khosrow I
People of the Roman–Sasanian Wars
Lazic War
George McKinley Treadwell (December 21, 1918 in New Rochelle, New York – May 14, 1967 in New York City) was an American jazz trumpeter and the manager of the Drifters.

Treadwell played in the house band at Monroe's in Harlem in 1941–1942, then worked with Benny Carter later in 1942 in Florida. Following stints with Ace Harris's Sunset Royals and Tiny Bradshaw, Treadwell worked with Cootie Williams (1943–1946) and J.C. Heard (1946–1947). As a member of Heard's ensemble, he accompanied Etta Jones and Sarah Vaughan, whom he married in 1947. He also recorded with Dicky Wells and Ethel Waters in 1946.

Treadwell quit playing late in the 1940s to work as Vaughan's manager, and continued in this capacity after their divorce in 1957. He also managed the Drifters and Ruth Brown and did artists and repertoire (A&R) work in the 1950s.

Treadwell met Fayrene Johnson in Los Angeles and they married in 1957.

After 1959 Treadwell also worked as a songwriter.

In 1967, Treadwell died suddenly, leaving his wife Faye to buy out his partners and manage The Drifters.

References

Howard Rye, "George Treadwell". Grove Jazz online.

1918 births
1967 deaths
American jazz trumpeters
American male trumpeters
Musicians from New Rochelle, New York
American music managers
The Drifters
Songwriters from New York (state)
Jazz musicians from New York (state)
American male jazz musicians
20th-century American male musicians
Kung Fu Finger Book is a 1979 Hong Kong film directed by Ke Kao with Min Kyu Choi, Amy Chum, Ke Kao. It is also called Kung Fu Fever and Black Dragon Fever.  It stars Dragon Lee and Ron van Clief.

Plot
There is a book with the deadly finger style of the late Bruce Lee.

External links

1979 films
Hong Kong action drama films
1970s Hong Kong films
Almon Mason Clapp (September 14, 1811 – April 9, 1899) was an American printer and politician, and the first person to hold the title Public Printer of the United States, from 1876 to 1877.

Biography
Clapp was born in Killingly, Connecticut in 1811, a descendant of immigrant Thomas Clapp of Dorchester, England and a cousin of Roger Clapp who arrived in America on the 1630 voyage of the Mary and John.  His family moved to Livingston County, New York in 1818, and at age 14 he became a printer's apprentice in Genesee, New York.  He moved to Buffalo, New York in 1828, and after finishing his education engaging in commerce for a few years, founded the Aurora Standard in 1835.  In 1838, he became editor and part owner of the Buffalo Commercial Advertiser, where he remained until he founded the Buffalo Express in 1846.  He served in the State Assembly in 1853 as a Whig, but by 1856 he was a leader at the Pittsburgh convention of the new Republican Party.  He was the party's nominee for Secretary of State of New York in the 1857 election, losing to Gideon J. Tucker.

In 1861, President Abraham Lincoln appointed Clapp to be postmaster of Buffalo.  He was reappointed in 1865 and served until President Andrew Johnson removed him in June 1866.  In 1869 the United States Senate elected him to be Congressional Printer, and he sold the Express.  When the title Public Printer of the United States was created in 1876, he continued as printer in that title for another year.  In 1877, he bought the National Republican newspaper in Washington, D.C., which was a pro-Republican paper, and owned it until 1880.

Clapp died at his home in Washington in April 1899.  He is buried at Forest Lawn Cemetery in Buffalo.

References

1811 births
1899 deaths
19th-century American newspaper editors
19th-century American newspaper founders
19th-century American newspaper publishers (people)
Editors of New York (state) newspapers
People from Killingly, Connecticut
Burials at Forest Lawn Cemetery (Buffalo)
Members of the New York State Assembly
New York (state) Republicans
New York (state) Whigs
United States Government Publishing Office
Voulismeno Aloni (Βουλισμένο Αλώνι, Greek: sunken threshing floor) is a sinkhole located at the feet of Mt Stroumboulas, next to the old national road, at the 14th kilometer from Heraklion to Rethymnon, on the island of Crete (35°19′48″N, 25°01′05″E).

It is a ground subsidence with a circular shape up to 90 meters in diameter. Its slopes are steep and vertical reaching up to 60 meters of height from the bottom of the formation. Descent into the interior is feasible on foot from the South-West side following a certain pathway.

Geologists believe that it is a sinkhole, formed by the depression of a cave, during the Pleistocene period.

In spite of what its name implies, it is believed that it was never used as a threshing floor.

Geology of Greece
Sinkholes of Europe
Landforms of Greece
Dancis is a surname. Notable people with the name include:

George Dancis (1931–2021), Australian basketball player,  participant in the 1956 Summer Olympics
Joseph Dancis (1916–2010), American pediatrician
Mike Dancis (1939–2020), Australian basketball player, participant in the 1964 Summer Olympics
MJ Department Stores Sdn Bhd is a popular retail company in Malaysia which offers items at a medium-to-high rate. The company opened its first store at Pertama Complex, Kuala Lumpur in September, 1976,with a retail space of 18,305 sq ft (1,705 sq metres). Metrojaya's latest outlet, in Berjaya Times Square closed in December 2009, after only three years of operation. Metrojaya currently has four outlets in Malaysia namely Mid Valley Megamall, Suria Sabah, Permaisuri Imperial City Mall and LaLaport BBCC. 
 
The Metrojaya group currently operates a chain of four department stores and more than 70 specialty stores that occupy over one million square feet of floor space, including Cape Cod, East India Company, Living Quarters, Reject Shop and Somerset Bay.

Retail operations
The company is principally involved in operating departmental stores and investment holding whilst its subsidiary companies are principally involved in property holding, investment holding as well as the operating of specialty stores and general merchandising stores. Metrojaya department stores offer a wide range of merchandise that cater to the needs and tastes of middle and high income groups. The group operates four department stores, one hypermarket store under the Cosmart name at the Bukit Jambul Complex in Penang and one "MJ by Metrojaya" Fashion Concept Store at The Curve in Mutiara Damansara.

The retail operations can be broadly classified as:

 Ladies Department (includes apparel and accessories);
 Gents Department (includes apparel and accessories);
 Juniors Department (for teens and young adults);
 Children Department;
 Homes Department (includes kitchen, bathroom, bedroom, garden);
 Cosmetics and Fragrances.

Department stores
West Malaysia
 Mid Valley Megamall, Kuala Lumpur (190,000 sq ft
 The Curve, Mutiara Damansara (60,000 sq ft) - closed 2021
Brem Mall, Kepong (46,000 sq ft)
Mitsui Shopping Park LaLaport BBCC, Bukit Bintang 

East Malaysia
 Suria Sabah, Kota Kinabalu (125,000 sq ft) - department store closed and relocated to smaller retail lot
 CityOne Megamall, Kuching (130,000 sq ft) - closed 2019
 Permaisuri Imperial City Mall, Miri
 ÆON Mall Kuching Central, Kuching

MJ Outlet
West Malaysia
 Ampang Point Shopping Centre, Ampang
Mitsui Outlet Park KLIA Sepang, Sepang

References

External links
Metrojaya Berhad (MYX: 4987), bursamalaysia.com
Company Overview of Metrojaya Berhad, bloomberg.com

1974 establishments in Malaysia
Department stores of Malaysia
Companies based in Kuala Lumpur
Companies formerly listed on Bursa Malaysia
Privately held companies of Malaysia
Malaysian companies established in 1974
Retail companies established in 1974
Nõmme Mire Nature Reserve is a nature reserve which is located in Järva County, Estonia.

The area of the nature reserve is 437 ha.

The protected area was founded in 2006 to protect valuable habitat types and threatened species in Kärevere, Pibari, Tännassilma, and Villevere villages (all in Türi Parish).

References

Nature reserves in Estonia
Geography of Järva County
Türi Parish
Piazzi  is an Italian surname, may refer to:
 Giuseppe Piazzi was an Italian Theatine monk, mathematician, and astronomer.
 Giuseppe Piazzi (Bishop), Italian prelate of 20th Century.
 Fladimir Rufino Piazzi Júnior, (born 1978) Brazilian footballer

Piazzi may also refer to:

 Charles Piazzi Smyth (1819-1900), English astronomer
 Piazzi (crater), a 2.3 km-deep lunar crater
Tai Om () is a village in Lam Tsuen, Tai Po District, Hong Kong.

Administration
Tai Om is a recognized village under the New Territories Small House Policy.

History
Tai Om was historically a single-clan Hakka village, settled by the Cheung family (). The founding ancestors had moved moved from Wuhua in Guangdong province to Tai Mo Shan, and later settled in Tai Om around 1800. (other sources mention that the village was founded in the 17th century)

At the time of the 1911 census, the population of Tai Om was 162. The number of males was 74.

Conservation
The Tai Om Feng Shui Woodland, covering an area of 2.7 hectares, was designated as a Site of Special Scientific Interest in 2005. It is located on a knoll behind the village. A part of it was converted into orchards in the 1940s.

Luk Tak Study Hall, built in the 1930s, has been listed as a Grade III historic building.

Tai Om Old Brick Kiln has been listed as a Site of Archaeological Interest.

See also
 Ping Long, a village adjecent to Tai Om, located to its north

References

External links

 Delineation of area of existing village Tai Om (Tai Po) for election of resident representative (2019 to 2022)
 Antiquities Advisory Board. Pictures of Luk Tak Study Hall, No. 36 Tai Om
 Antiquities Advisory Board. Historic Building Appraisal. Yuk Yin Study Hall, No. 37 Tai Om Pictures
 Tai Om Kiln at industrialhistoryhk.org

Villages in Tai Po District, Hong Kong
Lam Tsuen
Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and CD120b, is one of two membrane receptors that binds tumor necrosis factor-alpha (TNFα). Like its counterpart, tumor necrosis factor receptor 1 (TNFR1), the extracellular region of TNFR2 consists of four cysteine-rich domains which allow for binding to TNFα. TNFR1 and TNFR2 possess different functions when bound to TNFα due to differences in their intracellular structures, such as TNFR2 lacking a death domain (DD).

Function 

The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2 (TRAF2), which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

Clinical significance

CNS 

At least partly because TNRF2 has no intracellular death domain, TNFR2 is neuroprotective.

Patients with schizophrenia have increased levels of soluble tumor necrosis factor receptor 2 (sTNFR2).

Cancer 

Targeting of TNRF2 in tumor cells is associated with increased tumor cell death and decreased progression of tumor cell growth.

Increased expression of TNFR2 is found in breast cancer, cervical cancer, colon cancer, and renal cancer. A link between the expression of TNRF2 in tumor cells and late-stage cancer has been discovered. TNFR2 plays a significant role in tumor cell growth as it has been found that the loss of TNFR2 expression is linked with increased death of associated tumor cells and a significant standstill of further growth. There is therapeutic potential in the targeting of TNFR2 for cancer treatments through TNFR2 inhibition.

Systemic Lupus Erythematous (SLE) 

A small scale study of 289 Japanese patients suggested a minor increased predisposition from an amino acid substitution of the 196 allele at exon 6. Genomic testing of 81 SLE patients and 207 healthy patients in a Japanese study showed 37% of SLE patients had a polymorphism on position 196 of exon 6 compared to 18.8% of healthy patients. The TNFR2 196R allele polymorphism suggests that even one 196R allele results in increased risk for SLE.

Interactions 

TNFRSF1B has been shown to interact with:
 TRAF2, and
 TTRAP.

References

Further reading

External links 
 

TNF receptor family
Benjamin F. Jones (born December 24, 1966) is an American historian and academic administrator who is State Historian of South Dakota and Director of the South Dakota State Historical Society. He was previously Secretary of Education of South Dakota from January 2019 to December 2020.

Jones was born in Sioux Falls, South Dakota and graduated from DeSmet High School in South Dakota. He earned a bachelor's degree in history from South Dakota State University, a master's degree from the University of Nebraska–Lincoln, and a PhD from the University of Kansas. He served 23 years in the United States Air Force, where he attained the rank of lieutenant colonel, and taught at the Air Force Academy.

Jones was dean of the College of Arts and Sciences at Dakota State University from 2013 to 2019. In January 2019 he was appointed interim Secretary of Education by Governor Kristi Noem, and in May 2019 he was named permanent secretary. On December 9, 2020, Jones left to become State Historian, replacing Jay Vogt. He was replaced as Secretary of Education by Tiffany Sanderson, formerly a member of Noem's senior staff.

As secretary, Jones led the development of the department's 2019 strategic plan, which prioritizes reducing the achievement gap for students in poverty and improving academic performance among Native Americans. He has also supported legislation to expand civic education in the state.

In 2016, Jones published Eisenhower’s Guerrillas: The Jedburghs, the Maquis, and the Liberation of France, which examines Operation Jedburgh and is based on his 1998 Master's thesis.

Jones lives in Sioux Falls, South Dakota.

Works

References

External links 
 
 

Living people
1966 births
South Dakota State University alumni
University of Nebraska–Lincoln alumni
University of Kansas alumni
Educators from South Dakota
United States Air Force Academy faculty
Dakota State University faculty
People from Sioux Falls, South Dakota
Thomas Calvert may refer to:

 Thomas Calvert (divine) (1606–1679), English Nonconformist divine
 Thomas Calvert (MP) (1755–?) English Member of parliament for St Mawes 1792–1795
 Thomas Calvert (professor) (1775–1840), English Anglican priest and theologian
 Thomas Calvert (Royal Navy officer) (1883–1938), English Royal Navy officer of the First World War
DL E&C Co., Ltd. (), formerly the construction division of Daelim Industrial, is a construction company headquartered in Seoul, South Korea.

The fields covered by DL E&C as one of the top EPC companies in Asia to the Middle East include gas, petroleum refining, chemical and petrochemical, power and energy plants, building and housing, civil works, and industrial facilities.

History
The Daelim Group of Industries started out this venture in 1962 from Gyeongsangam-do.

Notable projects
D&L E&C's notable construction projects include 1915 Çanakkale Bridge, Sepung bridge, Geobukseon bridge, Cheong poong bridge and Brunei's Temburong Bridge. In 2013, Daelim was awarded with Malaysia's 3A 1200MW power plant project (US$1.2 billion) and Omani's Sohar Refinery Expansion Project (US$1 billion).

See also
Chaebol

References

External links
 

Conglomerate companies established in 1939
Companies listed on the Korea Exchange
South Korean brands
Companies based in Seoul
DL Group
1939 establishments in Korea
The 112th United States Congress began on January 3, 2011. There were 13 new senators (one Democrat, 12 Republicans) and 94 new representatives (nine Democrats, 85 Republicans) at the start of its first session. Additionally, three senators (one Democrat, two Republicans) and 10 representatives (seven Democrats, three Republicans) took office on various dates in order to fill vacancies during the 112th Congress before it ended on January 3, 2013.

The president of the House Democratic freshman class was Terri Sewell of Alabama, while the president of the House Republican freshman class was Austin Scott of Georgia. Additionally, the Republican's freshmen liaisons were Kristi Noem of South Dakota and Tim Scott of South Carolina.

This freshmen class was overwhelmingly Republican, resulting in an even larger prevalence of Republican freshmen than during the Republican Revolution of 1994, with approximately 23% of the 47 elected Republican senators and 33% of the 242 elected Republican representatives being first-timers.

Senate

Took office January 3, 2011

Took office during the 112th Congress

House of Representatives

Took office January 3, 2011

Took office during the 112th Congress

See also 
 List of United States senators in the 112th Congress
 List of members of the United States House of Representatives in the 112th Congress by seniority

Notes

References

External links
RealClearPolitics: Freshman Class of the 112th Congress

Freshman class members
112