Samantha912/NLP_A2_WTH huggingface dataset:
Metabolite channeling is the passing of the intermediary metabolic product of one enzyme directly to another enzyme or active site without its release into solution. When several consecutive enzymes of a metabolic pathway channel substrates between themselves, this is called a metabolon. Channeling can make a metabolic pathway more rapid and efficient than it would be if the enzymes were randomly distributed in the cytosol, or prevent the release of unstable intermediates. It can also protect an intermediate from being consumed by competing reactions catalyzed by other enzymes.

Mechanisms for channeling
Channeling can occur in several ways. One possibility, which occurs in the pyruvate dehydrogenase complex, is by a substrate being attached to a flexible arm that moves between several active sites (not very likely). Another possibility is by two active sites being connected by a tunnel through the protein and the substrate moving through the tunnel; this is seen in tryptophan synthase. A third possibility is by a charged region on the surface of the enzyme acting as a pathway or "electrostatic highway" to guide a substrate that has the opposite charge from one active site to another. This is seen in the bifunctional enzyme dihydrofolate reductase-thymidylate synthase. The channeling of aminoacyl-tRNA for protein synthesis in vivo has been also reported.

Controversies

Channeling of NADH between oxidoreductases
Some authors have maintained that direct transfer of NADH from one enzyme as product to another as substrate is a common phenomenon. However others, such as Gutfreund and Chock and Pettersson have argued that the experimental evidence is too weak to support such a conclusion. In a more recent study Svedružić and colleagues conclude that such direct transfer is a real phenomenon, but they sound a note of caution:Our results also show that it is impossible to design experiments that can conclusively analyze substrate channeling in cells if we do not understand the underlying molecular principles and the properties of the related enzymes.

Physiological effects of metabolite channeling
It is sometimes suggested, for example by Ovádi, that metabolite channeling decreases the concentration of metabolite in free solution. However, it has also been argued that there is no net effect on the free concentration in steady-state conditions, a claim disputed by others. More recent authors consider this and other questions about channeling to be unresolved: "Substrate channeling in vivo has also been a subject of yet to be resolved debates," or they recognize that an effect on free concentration exists, but is "generally small."

See also

 Enzyme kinetics
 Enzyme assay
 Enzyme catalysis

References

Enzyme kinetics
Fermi is a Turin Metro station, located in the Turin suburb of Collegno, near the intersection between Via Edmondo De Amicis and Via Enrico Fermi. Being the westerly terminus of Line 1, there is an adjacent park and ride lot with more than 300 spaces and connecting bus service from Rivoli. The station was opened on 4 February 2006 as the western terminus of the inaugural section of Turin Metro, between Fermi and XVIII Dicembre.

Services
 Parking lot with more than 300 spaces
 Ticket vending machines
 Handicap accessibility
 Elevators
 Escalators
 Active CCTV surveillance

References

Turin Metro stations
Railway stations opened in 2006
2006 establishments in Italy
Collegno
Railway stations in Italy opened in the 2000s
Lebanon is a town in the Greater Accra Region of Ghana and shares boundary with Ashaiman and Zenu. The town is divided into zones, from zone 1 to 5.

References 

Populated places in the Greater Accra Region
Savane is the final solo album by Malian musician Ali Farka Touré. It is the third and final part of the Hôtel Mandé Sessions, featuring Touré and Toumani Diabaté, recorded by World Circuit head Nick Gold. The album was released posthumously by World Circuit on 17 July 2006, more than four months after Touré's death.

The recording sessions at Hôtel Mandé in Bamako took place from June to July 2004. Touré, suffering from cancer, had wanted to remain in Mali, so a temporary studio was set up on the top floor of the hotel. Touré approved the final master of Savane just weeks before his death in March 2006. He said of the album: "I know this is my best album ever. It has the most power and is the most different."

Savane features a number of non-African blues musicians, such as Little George Sueref, Pee Wee Ellis, and also Touré's protégé since the age of 13, Afel Bocoum.

It was released to high critical acclaim, earning a 94 on Metacritic. The album was also included in the book 1001 Albums You Must Hear Before You Die.

In 2009. It was awarded a gold certification from the Independent Music Companies Association which indicated sales of at least 100,000 copies throughout Europe.

Track listing
"Erdi" – 4:42
"Yer Bounda Fara" – 4:18
"Beto" – 4:49
"Savane" – 7:43
"Soya" – 4:38
"Penda Yoro" – 5:25
"Machengoidi" – 3:35
"Ledi Coumbe" – 3:16
"Hanana" – 2:34
"Soko Yhinka" – 5:05
"Gambari Didi" – 3:49
"Banga" – 3:48
"N'Jarou" – 4:55

Personnel
 Ali Farka Touré – guitar, vocals, percussion
 Mama Sissoko – ngoni
 Bassekou Kouyate – ngoni 
 Dassy Sarré – ngoni
 Afel Bocoum – backing vocals (tracks 6, 7, 13)
 Alou Coulibaly – water calabash (7)
 Ramata Diakite – backing vocals (3)
 Massambou Wele Diallo – bolon (9)
 Oumar Diallo – bass (13)
 Fanga Diawara – njarka violin (1, 7, 9)
 Fain Dueñas – percussion (1, 3, 6, 9, 13)
 Pee Wee Ellis – tenor sax (1, 3, 13)
 Souleye Kané – backing vocals (2, 6, 7, 10), calabash (3, 5, 11, 12)
 Mamadou Kelli – voice (11)
 Ali Magassa – backing vocals (2, 6, 7, 10), guitar (5)
 Etienne Mbappé – bass (6)
 Yacouba Moumouni – flute (12)
 Hammer Sankare – backing vocals (2, 5, 6, 7, 13)
 Sonny – bass (10)
 Little George Sueref – harmonica (1, 6, 8)
 Marriame Tounkara – backing vocals (12)
 Brehima Toure – backing vocals (10)
 Oumar Touré – backing vocals (2, 6, 7, 10), congas (3)
 Yves Wernert – bass (1)

References

External links
 
 

Ali Farka Touré albums
Albums published posthumously
2006 albums
World Circuit (record label) albums
This list of monospaced typefaces details standard monospaced fonts used in classical typesetting and printing.

Additional monospaced typefaces

Comic Code, a monospaced adaptation of the most infamous yet most popular casual font. https://tosche.net/fonts/comic-code
Comic Shanns, a Comic Sans inspired monospaced font. https://github.com/shannpersand/comic-shanns
New Heterodox Mono by Hao Chi Kiang https://github.com/hckiang/font-new-heterodox-mono
Proggy programming fonts
Teeny Tiny Pixls is a 5x3 pixel font "with many European characters included". Its homepage is https://chequered.ink/ but the download link; https://www.fontspace.com/chequered-ink/teeny-tiny-pixls appears to be broken. It can be downloaded from https://www.dafont.com/teeny-tiny-pixls.font
Terminal
Cozette : A tiny bitmap programming font optimized for coziness, https://github.com/slavfox/Cozette.

See also
List of display typefaces
List of sans serif typefaces
List of script typefaces
List of serif typefaces

References

 
Monospace
Monospace
George and Tammy Super Hits is an album by American country music artists George Jones and Tammy Wynette released on May 2, 1995 on the Epic Records.

Track listing

External links
 George Jones' Official Website
 Tammy Wynette's Official Website
 Epic Record Label

1995 greatest hits albums
George Jones compilation albums
Tammy Wynette albums
Epic Records compilation albums
Jamie Murray and Neal Skupski were the defending champions, but chose to compete in San Diego with different partners instead.

Jonny O'Mara and Ken Skupski won the title, defeating Oliver Marach and Philipp Oswald in the final, 6–3, 6–4.

Seeds

Draw

Draw

References

External Links
 Main Draw

Sofia Open
Sofia Open
The South East London Green Chain, also known as the Green Chain Walk, is a linked system of open spaces between the River Thames and Crystal Palace Park in London, England. In 1977 four London boroughs and the Greater London Council created this Green Chain of 300 open spaces to protect them from building activity. The four London boroughs are Bexley, Bromley, Lewisham and Greenwich.  More recently it has been extended to include sections in Southwark. Many parts of the system are also part of the Capital Ring route.

The system begins at three places on the River Thames: Thames Barrier, Thamesmead, and the riverside at Erith. There are various circular walks along the route, and there is an offshoot from the main route to Chislehurst; and the next section reaches Crystal Palace via Bromley.
From there it goes north with branches to Dulwich and Nunhead.

The major open spaces in the Chain are:
 Lesnes Abbey
 Bostall Heath and Woods
 Parks in Charlton including Maryon Park, Maryon Wilson Park and Charlton Park
 Woolwich Common
 Plumstead Common
 Shooters Hill area, including Shrewsbury Park, Eaglesfield Park, Oxleas Wood and several other woods and open spaces
 Eltham Park and Common
 Eltham Palace
 Avery Hill Park
 Grove Park Nature Reserve
 Chinbrook Meadows
 Elmstead Wood
 Parks around Beckenham, including Beckenham Place Park
 Parks around Bromley including Sundridge Park and Chislehurst Common
 Crystal Palace Park

The complete list and the routes are to be found on TfL's Walk London site.

See also
 Greenway (landscape)
 Linear Park
 Trail
 Walking in London

References

External links
Official TfL site
Review of Green Chain
Route on OpenStreetMap, select your walk (takes time to load).
The Green Chain Walk on the Go Jauntly app, in partnership with Transport for London.

Walking in London
Parks and open spaces in London
Long-distance footpaths in England
Footpaths in London

Sydenham Wells Park ( Borough of Lewisham) is in the Green chain walk. It is one of the most attractive parks in the borough with a fine water feature, ponds, water play, flowerbeds and fine species of trees and shrubs.
It is on route from Crystal Palace to Sydenham Hill Woods with a Noticeboard and well signed markings...
Manganese phosphate may refer to:

Manganese(II) phosphate, 
Manganese violet, a Manganese(III) ammonium pyrophosphate used as a pigment 

Minerals
Gatehouseite, 
Hureaulite, 
Purpurite,  with varying amounts of iron depending upon its source
Waterhouseite, 

With Li or Na only
Lithiophilite, 
Natrophilite, 
Triphylite,  end member of solid solutions with lithiophilite

With Al or B only
Eosphorite, 
Seamanite, rare boron phosphate mineral, 
Sinkankasite, 

Mixed phosphate minerals with iron

Alluaudite, 
Childrenite, rare,  
Falsterite, rare, 
Ferraioloite, rare, . It is related to falsterite.
Graftonite, 
Maneckiite, rare, 
Messelite, 
Robertsite, 
Samuelsonite, 
Switzerite, 
Triplite, rare, 
Triploidite, uncommon, 
Whiteite is a rare hydrated phosphate mineral, with hydroxyl, Fe, Ca
Karahacılı is a village in Mersin Province, Turkey. It is a part of Yenişehir municipality of Mersin. of Mersin Province.  It is situated in the valley of Mezitli River between Bozön and Turunçlu at . The distance to Mersin is . The population of the village is 728 as of 2002. Main crops of the village are fruits and vegetables.

References

External links
Images
A public disclosure is any non-confidential communication which an inventor or invention owner makes to one or more members of the public, revealing the existence of the invention and enabling an appropriately experienced individual ("person having ordinary skill in the art") to reproduce the invention. A public disclosure may be any form of non-confidential communication. For example an academic poster, presentation to a symposium/conference, website article, book chapter, academic journal article, or even an unguarded conversation in a car park.

Patent law
In some countries, public disclosure may result in the immediate loss of invention patentability unless a patent application has already been filed, and disclosure may be considered to include oral as well as written communication.

Australia
The Full Federal Court of Australia held in Fuchs Lubricants v Quaker Chemical that the patent claims lacked novelty due to public disclosures made by the inventor Mr Thomas before any patent applications were filed.  The public disclosures arose in the following way.  In about September–October 2010, Mr Thompson conceived the idea of using dyes in hydraulic fluid to enable detection of fluid injection injuries.  He considered it would be necessary to conduct trials and experiments using hydraulic fluid in real operational mining equipment, so approached the engineering manager of Peabody Energy Australia Pty Ltd, which operated the Metropolitan mine in NSW.  Mr Thompson disclosed the invention by explaining his proposed method (i.e., the invention) and discussed the possibility of running trials and experiments at the Metropolitan mine.  A further disclosure occurred about a month later when, in the carpark of the Metropolitan mine, Mr Thompson demonstrated his invention to two Peabody managers.  The Court found that these disclosures were not confidential and therefore constituted public disclosures that compromised the novelty of the invention.

United States
In the U.S., public disclosure of an invention results in the loss of patentability of the invention after a period of one year. 

 establishes various statutory bars to invention patentability with regard to invention novelty; these explicit bars preclude patentability as exceptions to a general underlying entitlement.  The public disclosure bar is one of the bars established in section 102 (b):

"(b) the invention was patented or described in a printed publication in this or a foreign country or in public use or on sale in this country, more than one year prior to the date of the application for patent in the United States..."

"Printed publications" generally include all paper and electronic forms of publication.  For example, books, scientific journals, posters, conference slide presentations, and website articles would all qualify as disclosure media.

See also 
On-sale bar

References

External links 
 35 U.S.C. 102 Conditions for patentability; novelty and loss of right to patent.

United States patent law
Disclosure
Jasminum andamanicum is an endangered endemic wild ornamental species described in 1981 from the Andaman Islands in the Bay of Bengal from two old collections by Dr King's Collector in 1894 and another one by C. E. Parkinson in 1914 deposited at CAL and PBL. This species has not been recorded from the islands until 1991 by Mathew and Abraham from Shoal Bay. This species is an evergreen component of the lowland evergreen forests of Andaman Islands. It found to grow alonge the forest edges with ample sunlight.

References

andamanicum
Endemic flora of the Andaman Islands
Plants described in 1981
Midsund is a village in Molde Municipality in Møre og Romsdal county, Norway. The village is located on the western end of the island of Otrøya. The eastern end of the Midsund Bridge is located in the village of Midsund, connecting it to the neighboring island of Midøya to the west.

The  village has a population (2018) of 596 and a population density of .

This village is the site of most private commercial services such as a grocery store, bank, shops, restaurant, and gas stations for the Midsund area in Molde. Otrøy Church lies about  northeast of the village of Midsund.

The village was the administrative center of the old Midsund Municipality until 2020 when it was merged into Molde Municipality.

References

Villages in Møre og Romsdal
Molde
The Kriegsrohstoffabteilung (War Raw Materials Department) was an organisation set up in Germany to facilitate access to raw materials for the German military.

Walther Rathenau and Wichard von Moellendorff proposed setting up an organisation to centrally manage all war-essential goods and raw materials. This led the Prussian War Minister Erich von Falkenhayn to decree the establishment of the Kriegsrohstoffabteilung (KRA) on 13 August 1914. The KRA reopened factories which had shut down because they were not economically viable. They also promoted the substitution of more readily available materials for  scarce materials. One example was the use of the Haber-Bosch process of ammonia production, when the Allied Powers' blockaded the importation of Chilean saltpeter. By 1918 it had 2,500 employees.

Walther Rathenau was the first president of KRA, a position he held up until his resignation at the end of March 1915. He was replaced by Joseph Koeth.

References

German Empire in World War I
Walther Rathenau
Who Killed Nelson Nutmeg? is a 2015 British independent family comedy-mystery film written and directed by Tim Clague and Danny Stack and starring Bonnie Wright.

Premise
Four children on a summer camp holiday suspect the park's mascot, Nelson Nutmeg, has been murdered so they set out to investigate.

Cast
Bonnie Wright as Diane
Loretta Walsh as Billie
Hattie Gotobed as The Colonel
James Grogan as Woody
JJ Brown as Shiv
Jonah Alexander as Swindon
Mark Vernon Freestone as Uncle Derek
Russell Biles as Mr Slug
Jamie Lee-Hill as Nelson Nutmeg

Production
Who Killed Nelson Nutmeg? was filmed on location in Bournemouth and Bridport.  Most of the filming took place at the Freshwater Beach Holiday Park, near Bridport.  According to Danny Stack, filming began on late August 2014 and wrapped up in October 2014.

Release
The film premiered on 10 October 2015 at the 59th BFI London Film Festival.  On 24 June 2016 TriCoast Entertainment released the film on premium VOD and digital platforms.

Reception
Screen Daily was mixed in their opinion, closing their article with the statement "Nelson Nutmeg falls to pieces the moment you try and untangle the twist ending, suggesting that Clague and Stack may have rather underestimated the sophistication of their target audience." MuggleNet was more positive, writing "While a children’s film at its core, Who Killed Nelson Nutmeg? is thoroughly enjoyable for anyone, young or old."

References

External links
 
 

2015 films
2010s adventure comedy films
British adventure films
British independent films
British children's comedy films
British mystery films
British detective films
Films about missing people
Films about murder
2015 comedy films
2010s English-language films
2010s British films
Jeremiah Collison (12 August 1889 – 18 June 1956) was an Irish hurler and Gaelic footballer. Usually lining out in the backs, he was a member of the Tipperary team that won the 1916 All-Ireland Championship.

Collison began his club hurling with the Toomevara club, winning four championship medals between 1910 and 1914. He also played club hurling with Nenagh Éire Óg, Collegians and Moneygall.

After lining out for the Dublin senior team in the drawn All-Ireland final with Tipperary in 1908, Collison subsequently joined the Tipperary team in 1915. He won his first Munster medal in 1916 before later winning his sole All-Ireland medal after Tipperary's defeat of Kilkenny in the final. He won a second Munster medal in 1917.

Collison also had an active role as a member of the Old IRA. Appointed O/C of the No.2 Battalion North Tipperary Brigade IRA in 1918, his hurling career ended when he was imprisoned in Belfast for drilling members of the IRA. During his time at Crumlin Jail, Collison went on hunger strike. A supporter of the Anglo-Irish Treaty, Collison later served as a member of the Free State Army during the Civil War.

Honours

Toomevara
Tipperary Senior Hurling Championship (4): 1910, 1912, 1913, 1914

Tipperary
All-Ireland Senior Hurling Championship (1): 1916
Munster Senior Hurling Championship (2): 1916, 1917

References

1889 births
1956 deaths
Toomevara hurlers
Moneygall hurlers
Nenagh Éire Óg Gaelic footballers
Tipperary inter-county hurlers
Tipperary inter-county Gaelic footballers
Dublin hurlers
All-Ireland Senior Hurling Championship winners
Walter James (June 3, 1882 – June 27, 1946) was an American character actor.  He appeared in more than 50 films between 1915 and 1942. He was born in Chattanooga, Tennessee, and died in Gardena, California from a heart attack.

Partial filmography

 The Unbroken Road (1915)
 A Daughter of the Gods (1916) - Chief Eunuch
 Souls Adrift (1917) - A Swede Sailor
 The Idol Dancer (1920) - Chief Wando
 Dead Men Tell No Tales (1920) - José
 Fair Lady (1922) - Gian Norcone
 The Secrets of Paris (1922) - The Strangler
 Two Shall Be Born (1924) - Hund
 The Monster (1925) - Caliban
 The Everlasting Whisper (1925) - Aswin Brody
 Little Annie Rooney (1925) - Officer Rooney
 The Seventh Bandit (1926) - Ben Goring
 Glenister of the Mounted (1926) - Thorald
 Battling Butler (1926) - The Mountain Girl's Father
 The Kid Brother (1927) - Jim Hickory
 Rich Men's Sons (1927) - Clerk (uncredited)
 The Blood Ship (1927) - Capt. Angus Swope
 The Patent Leather Kid (1927) - Officer Riley
 The Irresistible Lover (1927) - Mr. Kennedy
 The Road to Ruin (1928) - Headwaiter (uncredited)
 The Big Killing (1928) - Sheriff
 The Wright Idea (1928) - Capt. Sandy
 Me, Gangster (1928) - Police Capt. Dodd
 The Divine Lady (1929) - One of Nelson's Ship's Officers (uncredited)
 Hell's Heroes (1929) - Sheriff
 Shadow of the Law (1930) - Captain of the Guards
 The Public Defender (1931) - Police Captain Anderson (uncredited)
 Street Scene (1931) - Police Marshal James Henry
 Scareheads (1931)
 Docks of San Francisco (1932) - Phony Café Waiter (uncredited)
 Police Court (1932) - Cappy Hearn
 Ann Vickers (1933) - Guard (uncredited)
 Hips, Hips, Hooray! (1934) - Mountaineer (uncredited)
 No More Women (1934) - Bouncer (uncredited)
 The Road to Ruin (1934) - Headwaiter (uncredited)
 The Cat's-Paw (1934) - Nightclub Doorman (uncredited)
 Jealousy (1934) - Cop (uncredited)
 Arizona Bad Man (1935) - Jack - Bartender
 The Public Menace (1935) - Policeman (uncredited)
 Hitch Hike Lady (1935) - Chief of Police (uncredited)
 Custer's Last Stand (1936, Serial) - Judge Hooker [Chs.12-14]
 Riffraff (1936) - Townsman (uncredited)
 Modern Times (1936) - Assembly Line Foreman (uncredited)
 White Fang (1936) - Posse Member (uncredited)
 Oh, Susanna! (1936) - Sage City Sheriff Briggs
 California Mail (1936) - Man Who Bets $1000 (uncredited)
 Mountain Justice (1937) - Juror (uncredited)
 This Is My Affair (1937) - Dinner Guest (uncredited)
 The Lone Ranger (1938, Serial) - Joe Cannon (Ch. 11) (uncredited)
 Professor Beware (1938) - Man with New Hat (uncredited)
 Disbarred (1939) - Juror (uncredited)
 Eternally Yours (1939) - Police Official (uncredited)
 Invisible Stripes (1939) - Worker (uncredited)
 Legion of the Lawless (1940) - Vigilante at Meeting (uncredited)
 The Kid's Last Ride (1941) - Bartender (uncredited)
 Citizen Kane (1941) - Ward Heeler (uncredited)
 The Lone Rider Fights Back (1941) - Bartender (uncredited)
 The Panther's Claw (1942) - Capt. Tom Henry
 Good Luck, Mr. Yates (1943) - Leading Citizen (uncredited)

External links

IBDb
IBDB 2

1882 births
1946 deaths
American male film actors
American male silent film actors
Male actors from Tennessee
20th-century American male actors