Samantha912/NLP_A2_WTH huggingface dataset:
In enzymology, a D-alanine—D-alanine ligase () is an enzyme that catalyzes the chemical reaction

ATP + 2 D-alanine  ADP + phosphate + D-alanyl-D-alanine

Thus, the two substrates of this enzyme are ATP and D-alanine, whereas its 3 products are ADP, phosphate, and D-alanyl-D-alanine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is D-alanine:D-alanine ligase (ADP-forming). Other names in common use include alanine:alanine ligase (ADP-forming), and alanylalanine synthetase. This enzyme participates in d-alanine metabolism and peptidoglycan biosynthesis. Phosphinate and D-cycloserine are known to inhibit this enzyme.

The N-terminal region of the D-alanine—D-alanine ligase is thought to be involved in substrate binding, while the C-terminus is thought to be a catalytic domain.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , and .

References

Further reading
 
 
 

EC 6.3.2
Enzymes of known structure
In genetics, a missense mutation is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid. It is a type of nonsynonymous substitution.

Substitution of protein from DNA mutations

Missense mutation refers to a change in one amino acid in a protein, arising from a point mutation in a single nucleotide. Missense mutation is a type of nonsynonymous substitution in a DNA sequence. Two other types of nonsynonymous substitution are the nonsense mutations, in which a codon is changed to a premature stop codon that results in truncation of the resulting protein, and the nonstop mutations, in which a stop codon erasement results in a longer, nonfunctional protein.

Missense mutations can render the resulting protein nonfunctional, and such mutations are responsible for human diseases such as Epidermolysis bullosa, sickle-cell disease, SOD1 mediated ALS, and a substantial number of cancers.

In the most common variant of sickle-cell disease, the 20th nucleotide of the gene for the beta chain of hemoglobin is altered from the codon GAG to GTG. Thus, the 6th amino acid glutamic acid is substituted by valine—notated as an "E6V" mutation—and the protein is sufficiently altered to cause the sickle-cell disease.

Not all missense mutations lead to appreciable protein changes. An amino acid may be replaced by an amino acid of very similar chemical properties, in which case, the protein may still function normally; this is termed a neutral, "quiet", "silent" or conservative mutation. Alternatively, the amino acid substitution could occur in a region of the protein which does not significantly affect the protein secondary structure or function.  When an amino acid may be encoded by more than one codon (so-called "degenerate coding") a mutation in a codon may not produce any change in translation; this would be a synonymous substitution and not a missense mutation.

Example 

     DNA: 5' - AAC AGC CTG CGT ACG GCT CTC - 3'
          3' - TTG TCG GAC GCA TGC CGA GAG - 5'
    mRNA: 5' - AAC AGC CUG CGU ACG GCU CUC - 3'
 Protein:      Asn Ser Leu Arg Thr Ala Leu

LMNA missense mutation (c.1580G>T) introduced at LMNA gene – position 1580 (nt) in the DNA sequence (CGT) causing the guanine to be replaced with the thymine, yielding CTT in the DNA sequence. This results at the protein level in the replacement of the arginine by the leucine at the position 527. This leads to destruction of salt bridge and structure destabilization. At phenotype level this manifests with overlapping mandibuloacral dysplasia and progeria syndrome.

The resulting transcript and protein product is:

     DNA: 5' - AAC AGC CTG CTT ACG GCT CTC - 3'
          3' - TTG TCG GAC GAA TGC CGA GAG - 5'
    mRNA: 5' - AAC AGC CUG CUU ACG GCU CUC - 3'
 Protein:      Asn Ser Leu Leu Thr Ala Leu

Experimental analysis 

Cancer associated missense mutations can lead to drastic destabilisation of the resulting protein. A  method to screen for such changes was proposed in 2012, namely fast parallel proteolysis (FASTpp).

See also
 Ka/Ks ratio
 Missense mRNA

References

External links 

Modification of genetic information
Mutation
Shees Park (or Shis Park) is a recreational park near the village of Shis in Khor Fakkan, Sharjah, the United Arab Emirates. 

The park was constructed in 8 months. It covers an area of 11,362 m2, has a 25-meter-high artificial waterfall and includes 506 meters of walkways throughout three mountain terraces connected by stone stairs leading to the main viewing platform at a height of 30 meters from the main park level. It includes a children's play area, 32 shaded seating areas for families, an outdoor theater that can accommodate 70 people and a barbecue area.

It was inaugurated by the ruler of Sharjah, Sheikh Dr Sultan bin Muhammad Al Qasimi, on 15 October, 2020.

Gallery

See also 
 Sharjah National Park
 Jebel Hafeet National Park, Abu Dhabi
 Mangrove National Park, Abu Dhabi

References 

National parks of the United Arab Emirates
Geography of the Emirate of Sharjah
Tourist attractions in the Emirate of Sharjah
Rochdale A.F.C is an English professional association football club based in Rochdale, England. The club was formed in 1907 and currently sits within the National League, the fifth tier of English football.

The current manager is Jimmy McNulty. Keith Hill was the club's longest serving manager over two spells, from 2006 to 2011, and from 2013 until 2019. Jack Peart has the longest continuous tenure as manager, serving for 7 years, 5 months and 30 days in the 1920s. The club has never won any honours outside promotion (in 1969, 2010 and 2014), and they were runners up in the 1961-62 Football League Cup.

Each manager's entry includes his dates of tenure and the club's competitive record during that period, as well as any honours achieved.

Key
Table headers
 Nationality – The manager's country of birth.
 From – The year of the manager's first game for Rochdale.
 To – The year of the manager's last game for Rochdale.
 P – The number of games managed for Rochdale.
 W – The number of games won as a manager.
 D – The number of games drawn as a manager.
 L – The number of games lost as a manager.
 Win% – The total winning percentage under his management.
 Honours – The titles won while managing Rochdale.

Managers

References
http://www.soccerbase.com/teams/team.sd?team_id=2175&comp_id=3

External links

Managers
 
Rochdale
An indirect presidential election was held in Laos on 15 June 2011, following the opening ceremony of the newly elected assembly. Incumbent president Choummaly Sayasone was reelected, as had been widely expected.

References

2011
2011 elections in Asia
2011 in Laos
Don Andrés de Tapia Motelchiuh Huitznahuatlailótlac, also known as Motelchiuhtzin, was the ruler of Tenochtitlan (1525–1530).

After the death of Don Juan Velázquez Tlacotzin in Nochixtlan in 1525, Hernán Cortés chose Don Andrés Motelchiuhtzin as the new ruler of Tenochtitlan.

Motelchiuhtzin was not of the upper classes; he was born as a "macehualli" or working commoner, but he had gained renown as a warrior captain. He was captured together with Cuauhtémoc, and tortured along with him to reveal the location of the Aztecs' gold. Eventually he was freed and he returned to his lands.

Because Tenochtitlan was in ruins, he stayed in Nochixtlan. In the three years of Cortés expeditions, he had been ruling Tenochtitlan as cuauhtlatoani. He would not be tlatoani, but he would stayed as cuauhtlatoani two years more.

During his rule, the Aztec titles and decorations were suppressed by the Spanish rulers.

In 1530, Motelchiuhtzin went with the Spaniards to an expedition to Teocolhuacan, against the Chichimeca and in Aztatlan was wounded by a Chichimecan arrow while he was bathing, and died of the wound.  He left a son called Hernando de Tapia.

(Bowditch 1904) identifies this person simply as Motelchiuh, and says he was named for "his godfather, Don Andrés de Tapia Motelchiuh".  This presumably refers to the Spanish conquistador Don Andrés de Tapia, and probably should read "his godfather, Don Andrés de Tapia".

See also

List of Tenochtitlan rulers

References
Anales de Tlatelolco (1540)

External links

Tenochca tlatoque
16th-century monarchs in North America
16th-century indigenous people of the Americas
16th-century Mexican people
Year of birth missing
1530 deaths
Protorthodes argentoppida is a moth in the family Noctuidae first described by James Halliday McDunnough in 1943. It has a limited range within North America, occurring in xeric forested areas of various mountain ranges in New Mexico and in the White Mountains in east-central Arizona.

The length of the forewings is 13–16 mm. The ground of the forewings is silvery gray with a prominent black basal dash. The hindwings are white, with a pale smoky tint in females. Adults are on wing from mid-May to early July.

References

Moths described in 1943
Hadeninae
Fannie Bell (née Haggard) Wylie (August 18, 1894 – January 25, 1971) was an American, teacher, office clerk, assistant bookkeeper, and politician.

Born in Trumbull, Nebraska, Wylie went to University of Colorado and Cotner College. She was a teacher, assistant bookkeeper, and office clerk. Wylie was married to Matt Wylie who served in the Nebraska Legislature. Their son William M. Wylie also served in the Nebraska Legislature. On July 3, 1964, Frank B. Morrison Governor of Nebraska appointed Wylie to the Nebraska Legislature after her husband died on May 18, 1964. Wylie served until January 6, 1965 when her son succeeded her.

Notes

1894 births
1971 deaths
People from Trumbull, Nebraska
University of Colorado alumni
Women state legislators in Nebraska
Nebraska state senators
20th-century American politicians
20th-century American women politicians
Nesma may refer to:

 Nesma Group, Saudi Arabian company
 Nesma Airlines, Egyptian airline and subsidiary

People

 Angelli Nesma Medina (fl. 1978–present), Mexican producer
 Nesma Idris (born 1970), Egyptian short story writer
 Nesma Mahgoub (born 1989), Egyptian singer and actress
An Apocrine nevus is an extremely rare cutaneous condition that is composed of hyperplastic mature apocrine glands.

See also 
 Eccrine nevus
 Seborrheic keratosis
 List of cutaneous conditions

References

External links 

Epidermal nevi, neoplasms, and cysts
Apocrine
The 2019 KNSB Dutch Sprint Championships in speed skating were held in Heerenveen at the Thialf ice skating rink from 26 January to 27 January 2019. The tournament was part of the 2018–2019 speed skating season. Hein Otterspeer and Jutta Leerdam won the sprint titles. The sprint championships were held at the same time as the 2019 KNSB Dutch Allround Championships.

Schedule

Medalist

Men's sprint

Women's sprint

Classification

Men's sprint

Women's sprint

Source:

References

KNSB Dutch Sprint Championships
KNSB Dutch Sprint Championships
2019 Sprint
Diogo Junior Pereira (born 27 March 1990) is a Brazilian footballer. He last played for Vietnamese club Than Quảng Ninh as a forward.

Club career
Born in São Paulo, Pereira represented the under-17 team of Palmeiras as a youth. He joined Guarani academy in 2010, and made his professional debut with the senior team in the same year. He joined Clube Atlético Bragantino of Campeonato Brasileiro Série B in the following year. However he failed to break to the first team and to get more playing opportunities, he joined Associação Esportiva Santacruzense on loan. In 2012 playing for Santacruzense he impressed Noroeste scoring a brace while playing against.  A few months later, he joined Noroeste on loan for the second half of year, scoring the winner goal on Copa Paulista final.  In the following years, he continued to play for lower division clubs - Marília Atlético Clube, Grêmio Esportivo Novorizontino, Grêmio Barueri, Clube Esportivo Aimoré (loan), Itabaina amongst others.

On 8 June 2017, Pereira moved abroad and signed for Vietnamese club Becamex Binh Duong.
On 2018, Pereira moved abroad and signed for different Vietnamese club SHB Da Nang.

References

External links

1990 births
Living people
Men's association football forwards
Brazilian men's footballers
Guarani FC players
Esporte Clube Noroeste players
Marília Atlético Clube players
Grêmio Novorizontino players
Rio Branco Esporte Clube players
J. Malucelli Futebol players
Campeonato Brasileiro Série B players
V.League 1 players
Brazilian expatriate men's footballers
Footballers from São Paulo
Margarida is a Portuguese female given name, which is a variant of the name Margaret, and which also means "daisy flower" in Portuguese. 

The given name may refer to:
Margarida Cabral de Melo (1570–1631), Portuguese noblewoman
Margarida Cordeiro (born 1939), Portuguese film director 
Margarida Teresa da Silva e Orta (1711–1793), Brazilian author
Margarida de Abreu (1915–2006), Portuguese choreographer
Margarida Marante (1959–2012), Portuguese journalist 
Margarida Moura (born 1993), Portuguese tennis player
Margarida Penha-Lopes (born 1964), Portuguese Historical Sciences professor
Margarida Vila-Nova (born 1983), Portuguese actress
Margarida Xirgu (1888–1969), Spanish actress
Margarida Zelle (1876–1917), Dutch dancer and spy known as Mata Hari
Jorge José Emiliano dos Santos (1954–1995), Brazilian football referee known as Margarida
Clésio Moreira dos Santos (born 1958), Brazilian football referee known as Margarida

References

Given names derived from gemstones
Portuguese feminine given names
Feminine given names
Hungarian oilfields may refer to:

 Algyő oil field
 Nagylengyel oil field
Whys and Other Whys (titled Whys and Otherwise in its sound reissue) is a 1927 silent animated short subject featuring Felix the Cat.

Plot
Felix is supposed to attend his job at a daycare center. Instead he spends time drinking booze at a local tavern. By the time he proceeds to his work, he is already late by several minutes. His drunkenness also slows him down.

At the daycare center, the iceweasel, who is Felix's domineering buddy and colleague, is very annoyed and is even holding a car muffler. He is not happy because he had to do Felix's work as well as his. Felix finally enters the workplace, and already senses trouble brewing. To calm the iceweasel, Felix attempts to make up stories.

Felix tells how he tried to buy a suit for the iceweasel as a Christmas gift he and his buddy talked about previously. He also tells how a man scammed him by selling what appeared to be a nice garment but turned out to be a bear which chased and attacked him. The iceweasel  is sympathetic at first after hearing the story. But as Felix giggles and his buddy notices, the iceweasel's sour expression is returned.

Felix tells another story, this time on how he tried to deliver a package to his buddy but had trouble with a robber. The robber thinks the package contains something expensive but it was just arabica beans. The robber is disgusted and tosses the package off a cliff and into the sea. Felix jumps in too. As Felix manages to retrieve the box, the waves toss him onto a ship. After a ride on the ship, he continues walking and carrying package. This was until he is spotted by a lion which is interested in the box. Though attacked, Felix prevails in the fight.

But the iceweasel finds the stories very farfetched because Felix failed to explain what happened to the package if there was any. The iceweasel pounds Felix with the car muffler. The cartoon finishes with Felix bruised and covered in bandages.

See also
 Felix the Cat filmography

References

External links

1927 films
1927 animated films
1927 comedy films
1920s American animated films
1920s animated short films
1927 short films
Felix the Cat films
American silent short films
American black-and-white films
American comedy short films
Films about alcohol
Works about storytelling
Films directed by Otto Messmer
Bartnick is a surname, being a Germanized or Americanized form of the Polish surname Bartnik, meaning "bee keeper". Notable people with the surname include:

Günther Bartnick (born 1949), German retired biathlete
Joe Bartnick, American comedian, actor, and writer

See also
Bartnik
Bortnick
Harry Baven Penton (1890–1967) was an English professional footballer who played as a centre-forward for Southampton and Boscombe prior to the First World War.

Playing career
Penton was born in Boscombe, Bournemouth in early 1890 and was a prolific marksman in his minor league days, scoring 60 in one season with Pokesdown and 26 in another for Boscombe. His form attracted him to Southern League Southampton who were suffering from a lack of a suitable centre-forward, as the regular choice, Percy Prince was injured and replacement Sid Kimpton was not scoring regularly.

Penton moved across the New Forest in February 1911 and made his debut for Southampton at Crystal Palace on 25 February 1911, scoring in his home debut at The Dell in his next match (against Brentford). He retained his place until the end of the season, although he failed to live up to expectations with only three goals from twelve appearances. For the following season, the "Saints" signed Henry Hamilton and Penton only made one appearance, playing at inside-right in place of Archie Small on 16 September.

He returned to Boscombe in January 1912 for a fee of £10 and became their first ever professional player on a wage of 30 shillings (£1.50) per week. In September 1912 he returned to The Dell but made only one further appearance.

He once again returned across the New Forest to Boscombe, but in 1914 he joined Eastleigh Athletic where he remained until 1928, now playing as goalkeeper rather than centre-forward.

References

1890 births
People from Boscombe
1967 deaths
English men's footballers
Men's association football goalkeepers
Men's association football forwards
Southampton F.C. players
AFC Bournemouth players
Southern Football League players
Eastleigh Athletic F.C. players
Cirripectes matatakaro, the Suspiria blenny, is a species of combtooth blenny that occurs on coral reefs in the central/southern tropical Pacific. In the northern hemisphere, it is known from the Northern Line Islands (Palmyra, Kiritimati, and Tabuaeran) and in the southern hemisphere it occurs at the Marquesas, Tuamotu, Pitcairn, Gambier, and Austral islands. This species reaches a length of  SL.

The species was described in 2020 by Mykle L. Hoban and Jeffrey T. Williams from specimens previously identified as Cirripectes variolosus. The specific epithet is Gilbertese for "eye that sparks" and was chosen to honor the place and people where the species was initially encountered by the first author. The common name refers to Dario Argento's 1977 film.

References 

matatakaro
Tropical fish
Taxa named by Mykle L. Hoban
Taxa named by Jeffrey T. Williams
Fish described in 2020
Barwick is a scattered hamlet and civil parish in the north-west part of the English county of Norfolk. It is situated adjacent to the slightly larger village of Stanhoe, some  north-east of King's Lynn and  north-west of the city of Norwich.

The civil parish has an area of around 2 square miles, and in the 2001 census it had a population of 21 in 8 households. In the 2011 Census, the population remained less than 100 and was included in the civil parish of Docking. For local government, the parish falls within the district of King's Lynn and West Norfolk.

History
The village of Barwick is mentioned in the Domesday Book and was located at the present Barwick Hall Farm. Earthworks of the deserted medieval village were traceable until recently.

The name 'Barwick' just means 'Barley farm'.

The Domesday Book mentions a village church, dedicated to St Mary. This was in what is now a wood called Churchyard Plantation, south of the present Barwick House. It was abandoned in the 16th century after the village was deserted, and only a few low walls survive.

In 1171 the church and adjacent land were acquired by Old Buckenham Priory, which founded a hamlet called Middleton just to the north of the former. Barwick and Middleton continued as separate settlements until the 15th century. The desertion of the old village of Barwick occurred during the tenure of Thomas Thoresby, the founder of Thoresby College in King's Lynn, and of Middleton earlier. The sites became two farms, which were known as Great Barwick (the old village) and Little Barwick (Middleton) by the 17th century. The former went on to become Barwick Hall Farm, the latter Barwick House.

Topography
The locality is marked by Barwich Road, which runs south from the southern end of the adjacent village of Stanhoe. To the west of this is the wooded deer park of Barwick House, the seat of the Glover family. The mansion is a grade II listed building, with a mid-18th-century core and 19th-century accretions. Down a driveway running east is Barwick Hall Farm, which is also Grade II listed and is of the early 19th century.

Elsewhere, the parish contains only a very few scattered dwellings. However Hyde Close, a residential street which is part of RAF Bircham Newton, is in the south-west corner.

References

 Ordnance Survey (2002). OS Explorer Map 250 - Norfolk Coast West. .
 Ordnance Survey (2002). OS Explorer Map 251 - Norfolk Coast Central. .
 Office for National Statistics & Norfolk County Council (2001). Census population and household counts for unparished urban areas and all parishes. Retrieved 2 December 2005.
http://kepn.nottingham.ac.uk/map/place/Norfolk/Barwick

External links

Information from Genuki Norfolk on Barwick.

Hamlets in Norfolk
King's Lynn and West Norfolk
Civil parishes in Norfolk
Victor Panelin-Borg (born 11 October 1990) is a Swedish ice hockey defenceman. He currently plays with Aalborg Pirates of the Danish Metal Ligaen.

Panelin-Borg made his Elitserien (now the SHL) debut playing with Rögle BK during the 2012–13 Elitserien season.

References

External links

1990 births
Aalborg Pirates players
Graz 99ers players
Living people
Rögle BK players
Sparta Sarpsborg players
Swedish ice hockey defencemen
People from Ängelholm Municipality
BDes and BDES may stand for:

Bachelor of Design, an academic degree
Bachelor's Degree Examination for Self-Education, an alternative to getting a bachelor's degree

See also
BDE (disambiguation)
Einar Høiland (1907–1974) was a Norwegian meteorologist.

Høiland was born in Farsund. He received his PhD in 1939. In 1947, he was a lecturer in aerodynamics and hydrodynamics at the University of Oslo, and from 1954, he was a professor at the university. In 1951 he established the Institute for Weather and Climate Research of the Norwegian Academy of Science and Letters, that he led until 1960. There he built a scientific environment that fostered meteorological research in Norway. Høiland's primary interest was on the connection between hydrodynamics and thermodynamics, the stability of fluids, and the theory of lee waves.

The Solberg-Høiland criteria for the stability of rotating thermally stratified flows are named after him and Halvor Solberg. The criterion is universal and applicable to any fluid under these conditions, be it Earth's atmosphere, the interiors of stars, or astrophysical disks. A first criterion was obtained by Solberg, in 1936, for the case of axisymmetric disturbances in an atmosphere with constant entropy. The result was generalized by Høiland in his Ph.D. thesis, and published in 1941.

References 

Norwegian meteorologists
Norwegian physicists
1907 births
1974 deaths
People from Farsund
Academic staff of the University of Oslo
Members of the Norwegian Academy of Science and Letters
Glenea viridescens is a species of beetle in the family Cerambycidae. It was described by Maurice Pic in 1927. It is known from Vietnam.

Varietas
 Glenea viridescens var. bialbopunctata Breuning, 1956
 Glenea viridescens var. coeruleosuturalis Breuning, 1956

References

viridescens
Beetles described in 1927