Samantha912/NLP_A2_WTH huggingface dataset:
Tandospirone (brand name Sediel) is an anxiolytic and antidepressant drug used in China and Japan, where it is marketed by Dainippon Sumitomo Pharma. It is a member of the azapirone class of drugs and is closely related to other azapirones like buspirone and gepirone.

Medical uses

Anxiety and depression
Tandospirone is most commonly used as a treatment for anxiety and depressive disorders, such as generalised anxiety disorder and dysthymia respectively. For both indications it usually takes a couple of weeks for therapeutic effects to begin to be seen, although at higher doses more rapid anxiolytic responses have been seen. It has also been used successfully as a treatment for bruxism.

Augmentation for depression
Tandospirone can be used as an effective augmentation, especially when coupled with fluoxetine or clomipramine.

Other uses

Tandospirone has been tried successfully as an adjunctive treatment for cognitive symptoms in schizophrenic individuals.

Side effects
Common adverse effects include:

 Dizziness
 Drowsiness
 Insomnia
 Headache
 Gastrointestinal disorders
 Dry mouth
 Negative influence on explicit memory function
Adverse effects with unknown frequency include:

 Hypotension (low blood pressure)
 Dysphoria
 Tachycardia
 Malaise
 Psychomotor impairment

It is not believed to be addictive but is known to produce mild withdrawal effects (e.g., anorexia) after abrupt discontinuation.

Pharmacology

Pharmacodynamics
Tandospirone acts as a potent and selective 5-HT1A receptor partial agonist, with a Ki affinity value of 27 ± 5 nM and approximately 55 to 85% intrinsic activity. It has relatively weak affinity for the 5-HT2A (1,300 ± 200), 5-HT2C (2,600 ± 60), α1-adrenergic (1,600 ± 80), α2-adrenergic (1,900 ± 400), D1 (41,000 ± 10,000), and D2 (1,700 ± 300) receptors, and is essentially inactive at the 5-HT1B, 5-HT1D, β-adrenergic, and muscarinic acetylcholine receptors, serotonin transporter, and benzodiazepine allosteric site of the GABAA receptor (all of which are > 100,000). There is evidence of tandospirone having low but significant antagonistic activity at the α2-adrenergic receptor through its active metabolite 1-(2-pyrimidinyl)piperazine (1-PP).

Society and culture

Name
Tandospirone has also been known as metanopirone.

Synthesis
The Noreximide [6319-06-8] precursor also has dual uses to make Taglutimide & Tripamide & Lurasidone.

The catalytic hydrogenation of cis-5-Norbornene-exo-2,3-dicarboxylic anhydride [129-64-6] (1) gives Norbornane-2exo,3exo-dicarboxylic Acid-anhydride [14166-28-0] (2). Reaction with aqueous ammonia leads to Exo-2,3-norbornanedicarboximide [14805-29-9] (3). Alkylation with 1,4-dibromobutane [110-52-1] (4) gives CID:10661911 (5). Alkylation of the remaining halogen with 2-(1-Piperazinyl)Pyrimidine [20980-22-7] (6) completed the synthesis of Tandospirone (7).

References 

5-HT1A agonists
Alpha-2 blockers
Aminopyrimidines
Antidepressants
Anxiolytics
Azapirones
Cyclopentanes
Imides
Piperazines
James Talbot is a Northern Irish international lawn and indoor bowler.

Bowls career
Talbot is from County Antrim, in Northern Ireland and he won a bronze medal in the triples and fours at the 2012 World Outdoor Bowls Championship.

He won the gold medal at the 2011 World Cup Singles in Warilla, New South Wales, Australia.

References 

Male lawn bowls players from Northern Ireland
Living people
Year of birth missing (living people)
Sportspeople from County Antrim
Brothel Scene or Scene in an Inn is an oil on panel painting by the Dutch Golden Age painter Frans van Mieris, executed c. 1658–1659. Since 29 January 1960 it has been in the collection of the Mauritshuis in The Hague.

It was first recorded in the collection of one Lady Seaforth. It was then owned by Ch. Bredel until 1 May 1875 and then by A. Devy of London until 16 June 1876. Its next owner was the Earl of Dudley, who sold it to E. Steinkopf of London on 25 June 1892. It next appears in the written record in 1935, when it was owned by the art dealer Duits and Company. Five years later it was owned by Fritz Mannheimer of Amsterdam.

In 1941 it was bought by Dienststelle Mühlmann of The Hague for Adolf Hitler, who placed it in the Führermuseum in Linz near his birthplace Braunau. It was later transferred to the Stichting Nederlands Kunstbezit and then to the Dienst voor's Rijks Verspreide Kunstvoorwerpen, both in The Hague.

References

1659 paintings
Paintings by Frans van Mieris the Elder
Paintings in the Mauritshuis
Prostitution in paintings
The Palazzo Corner Gheltof is Gothic-style palace located on the Grand Canal, in the Sestieri of San Marco, adjacent to the Palazzi Mocenigo, in Venice, Italy.

History
The building has undergone a number of renovations, including a major one in the 16th century.

References

Corner Gheltof
Corner Gheltof
Gothic architecture in Venice
A Charming Man () is a Czechoslovak comedy film directed by Martin Frič. It was released in 1941.

Cast
 Oldřich Nový as Viktor Bláha
 Ladislav Pešek as Jam Valtera
 Nataša Gollová as Polda Krusinová
 Lída Chválová as Karla Hasková
 Theodor Pištěk as Vitalis Hasek
 Ella Nollová as Grandmother Hasková
 Raoul Schránil as Ing. Ivan Molenda
 Jaroslav Marvan as JUDr. Kouril, advokát
 František Filipovský as Jaroslav Stárek
 Antonín Zacpal as Prof. Matousek
 Svetla Svozilová as Matousek's wife
 Zdeňka Baldová as Mrs. Malá, widow
 Blažena Slavíčková as Emilka
 Ferenc Futurista as Mr. Fretka
 Marie Blazková as Woman

References

External links
 

1941 films
1940s Czech-language films
1941 comedy films
Czechoslovak black-and-white films
Films directed by Martin Frič
Czechoslovak comedy films
1940s Czech films
Ancoub Mze Ali (born 11 February 1996) is a footballer who plays for the B-team of French club RC Lens and the Comoros national football team.

International career
Mze Ali was born in Nice, France, to Comorian parents. He represented France at the U17 level in 2013.

He debuted for Comoros in a friendly 1–1 draw with Gabon on 15 November 2016.

References

External links
 
 
 OGC Nice Profile 
 
 FootNational Profile

1996 births
Living people
Footballers from Nice
Men's association football midfielders
Comorian men's footballers
Comoros men's international footballers
French men's footballers
France men's youth international footballers
French sportspeople of Comorian descent
Championnat National 2 players
Comorian expatriate men's footballers
Expatriate men's footballers in France
Joe McCormick was an actor, director, and presenter. He was accidentally shot while filming Whiplash.

Filmography

Film
On the Beach (1959) as Ackerman
One Bright Day (TV film) (1959) as Julian Prescott
Thunder on Sycamore Street (TV film) (1960) as actor

Television
Tuesday at One (1957) as Presenter
The Joe McCormick Show (1959) as Presenter
Whiplash (1960–61) as actor
Consider Your Verdict (1962) as actor
Time Out  (1963) as actor
Barley Charlie (1964) as actor
Homicide (1966) as actor

As crew
The Adventures of the Terrible Ten (1960) - writer, director
The Ten Again (1963) - director
Adventures of the Seaspray (1965) - director
Funny Things Happen Down Under (1965) - director
The Magic Boomerang (1965–66) - director

References

External links
Joe McCormick at IMDb

Australian actors
Ella Wiebe is a member of the Football Ferns, the New Zealand women's association football team.

Wiebe, born in Germany but now a naturalised New Zealander, made her senior international debut for New Zealand as a substitute in a friendly against Japan on 14 November 2009.

References

Living people
New Zealand women's international footballers
New Zealand women's association footballers
German emigrants to New Zealand
1978 births
Women's association football forwards
New Zealand expatriate sportspeople in Germany
Kressbronn am Bodensee is a municipality and a village in the district of Bodensee in Baden-Württemberg in Germany. It lies on Lake Constance.

Between 1919 and 2011, Kressbronn was the site of the Bodan-Werft shipyard, which built many of the ferries and other vessels used on Lake Constance and other Alpine lakes.

The lawyer Nicolas Becker was born in Kressbronn am Bodensee in 1946.

Demographics 
Population development:

References 

Bodenseekreis
Yiinthi is a genus of South Pacific huntsman spiders that was first described by V. T. Davies in 1994. Y. lycodes was transferred from Heteropoda.

Species
 it contains eight species, found in Papua New Guinea and Australia:
Yiinthi anzsesorum Davies, 1994 – Australia (Queensland)
Yiinthi chillagoe Davies, 1994 – Australia (Queensland)
Yiinthi gallonae Davies, 1994 – Australia (Queensland)
Yiinthi kakadu Davies, 1994 – Australia (Western Australia, Northern Territory)
Yiinthi lycodes (Thorell, 1881) – New Guinea, Australia (Queensland)
Yiinthi molloyensis Davies, 1994 – Australia (Queensland)
Yiinthi spathula Davies, 1994 (type) – Australia (Queensland)
Yiinthi torresiana Davies, 1994 – Australia (Queensland)

See also
 List of Sparassidae species

References

Araneomorphae genera
Sparassidae
Spiders of Asia
Spiders of Australia
Taxa named by Valerie Todd Davies
Amethyst Bradley "Surprise" Ralani (born 4 October 1987) is a South African professional soccer player who plays for Mamelodi Sundowns in the Premier Soccer League.

Career
Playing in the  2016 Allsvenskan, Helsingborgs IF signed him until the conclusion of the current season. He made his debut in July 2016.

Ralani returned to South Africa in January 2018, signing for Premier Soccer League club Cape Town City.

References

External links

1987 births
Living people
People from Kimberley, Northern Cape
South African men's soccer players
Men's association football midfielders
Helsingborgs IF players
IFK Hässleholm players
Landskrona BoIS players
Lyngby Boldklub players
Cape Town City F.C. (2016) players
Mamelodi Sundowns F.C. players
Allsvenskan players
Superettan players
Danish 1st Division players
South African Premier Division players
South African expatriate men's soccer players
South African expatriate sportspeople in Sweden
South African expatriate sportspeople in Denmark
Expatriate men's footballers in Sweden
Expatriate men's footballers in Denmark
Mahogany refers to dark-colored wood from various types of tree.

Mahogany may also refer to:

Botany and forestry
 Three species in the genus Swietenia:
 Swietenia macrophylla
 Swietenia mahagoni
 Swietenia humilis
 Eastern Australian trees in the genus Karrabina
 African Mahogany:
 Afzelia, genus in the family Fabaceae
 Khaya, genus in the family Meliaceae
 Blue Mountains mahogany, Eucalyptus notabilis
 Chinese mahogany, Toona sinensis
 Dundas mahogany, Eucalyptus brockwayi
 Indian mahogany, Toona ciliata
 Indonesian mahogany, Toona sureni
 Mountain mahogany:
 species of trees in the genus Cercocarpus
 Eucalyptus notabilis
 Natal mahogany, Trichilia emetica
 Philippine mahogany:
 Shorea in the dipterocarp family Dipterocarpaceae
 Toona calantas and other species in the mahogany family Meliaceae
 Red mahogany:
 Eucalyptus pellita
 Eucalyptus resinifera
 Eucalyptus scias, large-fruited red mahogany
 Southern mahogany, Eucalyptus botryoides
 Swamp mahogany:
 Lophostemon suaveolens, native to Australia and New Guinea
 Eucalyptus robusta
 Swan River mahogany, Eucalyptus marginata, also called jarrah
 Thick-leafed mahogany, Eucalyptus carnea
 White mahogany:
 Eucalyptus acmenoides
 Eucalyptus apothalassica
 Eucalyptus psammitica
 Eucalyptus tenuipes, narrow-leaved white mahogany
 Eucalyptus umbra, broad-leaved white mahogany

Places
 Mahogany Mountains, a mountain range on the Nevada-Utah border
 Mahogany Mountain, an ancient volcano on the border between Oregon and Idaho
 Mahogany Hills, a mountain range in Nevada
 Mahogany, Calgary, a neighbourhood in Calgary, Alberta, Canada
 Mahogany Bluff, Graham Land, Antarctica

Arts & entertainment
 Mahogany (band), a band from Brooklyn, New York, USA
 Mahogany (film), starring Diana Ross
 Mahogany (soundtrack), to the film
 "Mahogany", a song by Lil Wayne from the album Funeral
 Mahagonny, the fictional city in the opera Rise and Fall of the City of Mahagonny

Other
 Mahogany (color), inspired by the wood
 Mahogany (drink), a blend of gin and treacle
 Mahogany (e-mail client), an OpenSource cross-platform e-mail and news client
 Mahogany (horse), Australian racehorse
 USS Mahogany (AN-23), a net-laying ship in World War II
 Mahogany Avenue, a road in Tagaytay, Cavite, Philippines
 Mahogany Research Project, initiative by Shell Oil to procure oil in Colorado, USA

See also
 Mahogany Ship, possibly mythical wrecked ship in south-western Victoria, Australia
 Honey Mahogany (born 1983), Ethiopian-American former drag queen and politician
 Kevin Mahogany (1958–2017), American jazz vocalist
Bob chorba () is a chorba, a Bulgarian soup. It is made from dry beans, onions, tomatoes, chubritza or dzhodzhen (spearmint) and carrots.

Local variations may also exclude the carrots or include paprika, potatoes or even some kind of meat. Historically, it has been a common soup and staple food at Bulgarian monasteries.

See also
 Bulgarian cuisine
 List of bean soups
 List of soups

References 

Bulgarian cuisine
Legume dishes
Bean soups
Staple foods
Tomato dishes
Dil Mom Ka Diya () is a 2018 Pakistani drama serial that premiered on 28 August 2018 on ARY Digital. It is written by Saira Raza and directed by Shahid Shafat. It stars Neelam Muneer, Yasir Nawaz, Hira Mani and Imran Ashraf. It is produced by Humayun Saeed and Shehzad Nasib.

Cast
Yasir Nawaz as Afzal
Neelam Muneer as Ulfat
Hira Mani as Tamkinat
Imran Ashraf as Azhar
Alizey Shah as Farhat
Erum Akhtar as Salma; Afzal's sister
Qavi Khan as Maulvi Sahab: Ulfat and Farhat's father
Nida Mumtaz as Ulfat and Farhat's mother
Hassam Khan as Akmal; Afzal's younger brother
Zubi Majeed  as Kausar; Afzal's younger sister
Salman Faisal as Tipu

Reception 
The show received huge popularity and viewership during its broadcast. The  self-centred and greedy character of Ulfat received praise from the critics and was also liked by the viewers. The most popular serial of that time, it received the highest TRPs of 18, which became the highest ever rating of any TV program in Pakistan. Later, this record was broken by 2019's blockbuster Mere Paas Tum Ho.

Accolades

References

External links

2018 Pakistani television series debuts
2018 Pakistani television series endings
ARY Digital
ARY Digital original programming
Television shows set in Karachi
is a Japanese actress and gravure idol who has appeared in a number of feature films and television series. She is affiliated with Horipro.

Biography
In 2005, Midori was awarded the Grand Prix at the 30th Horipro Tarento Scout Caravan Memorial Audition 2005. The same year in May, Midori's acting debut was in GyaO's internet drama, Shojo ni wa Mukanai Shokugyo.

On April 3, 2006, her gravure debut was on the cover of Young Magazine. The following year, Midori was selected for Nippon Telegenic 2007.

Filmography

TV series

Films

References

External links
 Official profile at Horipro 
 

21st-century Japanese actresses
Japanese gravure models
Japanese television personalities
1991 births
Living people
People from Osaka Prefecture
Slavko Zagorac (; 30 April 1909 – 14 February 1988) was a Bosnian Serb football manager and player.

Playing career

Club
Zagorac was born in Glamoč (at the time in Austria-Hungary) and started his career in 1924 with Banja Luka clubs SK Balkan and SK Krajišnik, before he moved to Slavija Sarajevo two years later. He played over 500 official matches with the club and was considered to be one of the best full-backs in the royal Yugoslavia. Many reports from that time are telling about his powerful shots and tackles. He played for Slavija until 1941 when, due to the beginning of the World War II, the championship was interrupted.

International
Zagorac made his debut for Yugoslavia in an April 1932 friendly match away against Spain and has earned a total of 7 caps, scoring no goals. He is the first player from a Bosnian club who played for the national team. His final international was a September 1938 Eduard Benes Cup match against Romania.

Managerial career
After World War II, Zagorac continued his football career as a coach. He was a coach in both FK Sarajevo and Željezničar.

Personal life
He lived in Sarajevo (at the time SR Bosnia and Herzegovina, SFR Yugoslavia), where he died at the age of 79.

References

External sources

 Career story at reprezentacija.rs

1909 births
1988 deaths
People from Glamoč
Sportspeople from Canton 10
People from the Condominium of Bosnia and Herzegovina
Serbs of Bosnia and Herzegovina
Men's association football defenders
Bosnia and Herzegovina men's footballers
Yugoslav men's footballers
Yugoslavia men's international footballers
FK Slavija Sarajevo players
Bosnia and Herzegovina football managers
Yugoslav football managers
FK Željezničar Sarajevo managers
FK Sarajevo managers
In physiology, intrapleural pressure refers to the pressure within the pleural cavity. Normally, the pressure within the pleural cavity is slightly less than the atmospheric pressure, which is known as negative pressure. When the pleural cavity is damaged or ruptured and the intrapleural pressure becomes greater than the atmospheric  pressure, pneumothorax may ensue.

Intrapleural pressure is different from intrathoracic pressure. The thoracic cavity is the space that includes the pleura, lungs, and heart, while the pleural space is only the space between the parietal pleura and visceral pleura surrounding lungs.

Intrapleural pressure depends on the ventilation phase, atmospheric pressure, and the volume of the intrapleural cavity.

At rest, there is a negative intrapleural pressure. This provides a transpulmonary pressure, causing the lungs to expand. If humans didn't maintain a slightly negative pressure even when exhaling, their lungs would collapse on themselves because all the air would rush towards the area of lower pressure. Intra-pleural pressure is sub-atmospheric. This is due to the recoil of the chest and lungs away from each other.

Müller's maneuver can temporarily but significantly decrease the intrapleural pressure.

The relationship between the intra-pulmonary pressure and intra-pleural pressure is that the pressure becomes more negative during inspiration and allows air to get sucked in (Boyle's law)  vs  relationship and during expiration, the pressure becomes less negative (Note: still less than atmospheric pressure, also take note of the partial pressure of carbon dioxide) and the air is given out. The only difference between the pressures is that intra-pleural pressure is more negative than intra-pulmonary pressure.

Factors affecting are:

Physiological effects:

 Müller's maneuver (forced inspiration against a closed glottis results in negative pressure)
 
 Deep inspiration

Pathological effects:

 Emphysema
 
 Pneumothorax Condition

A person breathing at rest inhales and exhales approximately half a liter of air during each respiratory cycle, which is called tidal volume. The respiratory rate is directly affected by the concentration of carbon dioxide in the blood. Lungs do not collapse after forceful respiration because of the residual volume.

References

Books

 

Respiratory physiology
Pulmonology
John Henry Knox (26 July 1788 - 27 August 1872), was a Tory Member of the Parliament of the United Kingdom who represented the constituency of Newry from 1826 to 1832.

References

External links 
 

Tory MPs (pre-1834)
Members of the Parliament of the United Kingdom for Newry (1801–1918)
UK MPs 1826–1830
UK MPs 1830–1831
UK MPs 1831–1832
1788 births
1872 deaths
Erin Burdette (born April 19, 1983) is an American former professional tennis player.

Biography
Burdette, a right-handed player, was born and raised in the state of Georgia. As a junior, she was a girls' doubles runner-up at the 2000 Australian Open, partnering Lauren Barnikow. She won her first professional singles title at El Paso in 2000.

At the 2001 US Open she and Megan Bradley received a wildcard into the women's doubles main draw, reaching the second round. They also played together in the girls' doubles and won their way through to the semi-finals.

The eldest of three sisters to play college tennis for Stanford, Burdette was a four-time All-American and featured in three NCAA championships winning teams. She was the 2005 NCAA doubles champion with Alice Barnes in 2005, beating Stanford teammate Amber Liu and Anne Yelsey in the final. Both of her sisters, Lindsay and Mallory, both also later won NCAA doubles championships.

She now works as a veterinarian in San Francisco.

References

External links
 
 

1983 births
Living people
American female tennis players
Stanford Cardinal women's tennis players
Tennis people from Georgia (U.S. state)
Sportspeople from Macon, Georgia
Reigi () is a village in Hiiumaa Parish, Hiiu County in northwestern Estonia.

History
In 1984 Estonian writer Herman Sergo published the novel Näkimadalad, whose title is based on the name of the Nekmangrund shoal. In his three-volume work Sergo portrays the tragic fate of the Estonian Swedes living in Reigi village, located to the south of the shoal on Hiiumaa Island, which were deported in the 18th century to Southern Ukraine following a Russian Imperial decree.

See also
Reigilaid
Hiiu Shoal

References

Villages in Hiiu County

sv:Dagö#Byar
Tabagie is a Mi'kmaq word, often found in historical descriptions of solemn feasts in Quebec and Maritime Canada.  A tribal unit would call a tabagie to observe a solemn event, such as (but not limited to) the imminent death of a senior tribal member.  The term is also found in The Voyages of Samuel De Champlain, as Algonquins prepare to "put to death their prisoners in a festive tabagie".  On 27 May 1603, a solemn tabagie or "feast" held at Tadoussac "reunited the Frenchmen Gravé du Pont and Champlain with the Montagnais, the Algonquins, and the Etchimins," and marked the beginning of an enduring alliance between these peoples.  The term may be derived from tabac (tobacco), which was smoked as an essential element of the ceremony of the feast.

See also
 Tabagie (room)

References

Native American culture
First Nations culture
Mi'kmaq
Admiral Percy may refer to:

Algernon Percy, 10th Earl of Northumberland (1602–1668), English Lord High Admiral
Henry Percy, 1st Earl of Northumberland (1341–1408), English Admiral of the Northern Seas
Josceline Percy (Royal Navy officer) (1784–1856), British Royal Navy vice admiral
Thomas Percy, Earl of Worcester (1343–1403), English Admiral of the Kings Fleet in Ireland
William Henry Percy (1788–1855), British Royal Navy rear admiral
Chicago Solo is an album by the British jazz saxophonist Evan Parker, recorded in 1995 and released on Okka Disk. After eight records of solo soprano saxophone, it was his first unaccompanied tenor sax record.

Reception

In his review for AllMusic, Thom Jurek states: "This is a fascinating and very listening disc of solo improvisations, one that is likely never to find a wide enough audience for its brilliant accomplishment on tenor saxophone."

The Penguin Guide to Jazz describes the results of his first full programme of tenor playing as "extraordinary, music of intense focus and a fearsome weight and intensity of tone."

Track listing
All compositions by Evan Parker
 "Chicago Solo [12]"  – 1:44
 "Chicago Solo [3]"  – 4:40
 "Chicago Solo [4] for Chris McGregor"  – 3:18
 "Chicago Solo [5]"  – 6:56
 "Chicago Solo [6]"  – 3:20
 "Chicago Solo [7]"  – 5:13
 "Chicago Solo [8] for Lee Konitz"  – 2:57
 "Chicago Solo [9]"  – 2:15
 "Chicago Solo [10]"  – 4:46
 "Chicago Solo [11] for Mr. Braxton"  – 1:44
 "Chicago Solo [13]"  – 4:04
 "Chicago Solo [14]"  – 5:26
 "Chicago Solo [15]"  – 4:23
 "Chicago Solo [16] for George Lewis"  – 8:34

Personnel
Evan Parker – tenor sax

References

1997 albums
Evan Parker albums
Okka Disk albums