Samantha912/NLP_A2_WTH huggingface dataset:
Cartilage–hair hypoplasia (CHH) is a rare genetic disorder. Symptoms may include short-limbed dwarfism due to skeletal dysplasia, variable level of immunodeficiency, and predisposition to cancer. It was first reported by Victor McKusick in 1965.

Signs and symptoms
 Short limb dwarfism
 Very fine, light hairs and eyebrows
 Hyperextensible joints of hand and feet
 Abnormalities of spine
 Neutropenia
 Defective antibody and cell mediated immunity

Genetics

CHH is an autosomal recessive inherited disorder. It is a highly pleiotropic disorder. A rarely encountered genetic phenomenon, known as uniparental disomy (a genetic circumstance where a child inherits two copies of a chromosome from one parent, as opposed to one copy from each parent) has also been observed with the disorder.

An association between mutations near or within the ncRNA component of RNase MRP, RMRP, has been identified. The endoribonuclease RNase MRP is a complex of RNA molecule and several proteins and it participates in cleavage of mitochondrial primers responsible for DNA replication and in pre-rRNA processing in the nucleolus. The locus of the gene has been mapped to the short arm of chromosome 9.

Immunodeficiency
Patients with CHH usually suffer from cellular immunodeficiency. In the study of 108 Finnish patients with CHH, there was detected mild to moderate form of lymphopenia, decreased delayed type of hypersensitivity and impaired responses to phytohemagglutinin. This leads to susceptibility to and, in some more severe cases, mortality from infections early in childhood. There has also been detected combined immunodeficiency in some patients.
Patients with CHH often have increased predispositions to malignancies.

Diagnosis

Treatment

A verified treatment for this disease is yet to be discovered.

See also
 List of cutaneous conditions
 List of radiographic findings associated with cutaneous conditions

References

Further reading

External links

IUIS-PID table 3 immunodeficiencies
Genodermatoses
Autosomal recessive disorders
Ribosomopathy
Noninfectious immunodeficiency-related cutaneous conditions
Rare genetic syndromes
Yakhak  () is a village in Herat Province in northwestern Afghanistan.

See also 
 Herat Province

References 

Populated places in Herat Province
Villages in Afghanistan
Kingwood Christian School (KCS) was a private Christian school in Alabaster, Alabama, in the Birmingham, Alabama metropolitan area. It had grades K-12.

History
First Assembly of God, a church, created the school in 1979. The church later changed its name to Kingwood Church.

By 2018 the institution spent $12,000 for safety measures including panic button necklaces on teachers, in-classroom cameras, a "school resource officer", and other extra security cameras.

In spring 2019 the 12th grade class had 35 students, and enrollment was 300 total. According to the headmaster, Ruth Gray, the enrollment decline was due to the school having to compete with other schools which did not exist when the school was first established, as well as an increase in homeschooling. According to Gray, the school had so few students that it could no longer optimally function. Therefore it closed operations that spring. Some area Christian schools which had previously decided not to take new applicants allowed former students of KCS to submit applications, and other former students entered public school systems.

The church itself remained open and did not shutter its Kingwood Christian Child Development Center.

References

External links
 
 

Private K-12 schools in Alabama
Christian schools in Alabama
Schools in Shelby County, Alabama
1979 establishments in Alabama
Educational institutions established in 1979
2019 disestablishments in Alabama
Educational institutions disestablished in 2019
Defunct schools in Alabama
John Hettle (May 23, 1842 – September 20, 1897) was an English-born merchant and political figure in Manitoba. He represented Turtle Mountain from 1888 to 1897 in the Legislative Assembly of Manitoba as a Liberal.

He was born in Norham, Northumberland and came to Hullet Township, Huron County in Canada West with his family in 1857. Hettle later moved west, settling in Boissevain, Manitoba and going into business as an implement dealer. He served on the municipal council and was secretary-treasurer for the Turtle Mountain school board.

In 1869, Hettle married Ellen Walker. He died in office at the age of 55.

References 

1842 births
1897 deaths
Manitoba Liberal Party MLAs
People from Norham
People from Huron County, Ontario
State I Am In or The State I Am In may refer to:

 The State I Am In (film), 2000 German film
 "State I'm In", 2014 song by Needtobreathe
 State I'm In (album), 2019 album by Aaron Lewis
 The State I'm In (Louie Louie album), 1990
 The State I'm In (Leigh Nash album), 2015
 "The State I Am In", song from the 1996 album Tigermilk by Belle & Sebastian
 "The State I'm In", song from the 1995 eponymous album by Ednaswap
Flymore are a Russian nu metal band from Ivanovo that were formed in 2002.

History
The band was formed in 2002 in Ivanovo, Russia after the split of another band, Millenium. It was founded by guitarist Igor "Fly" Muchin and vocalist Max "Frozt" Morozov. In 2009, they released their first studio album entitled "Millenium IV V," which was recorded on the label Right Recordings. One of the songs ("All The Time I Bled") was shot with a music video. On February 26, 2013, the band released an EP called "Mind Tricks".

Discography

Studio albums
 Millenium IV V (2009)

EPs
 Mind Tricks (2013)

Members

Current
Max "Frozt" Morozov – vocals (2002–)
Igor "Fly" Mukhin – guitar (2002–)
Paul "Rage" Jones – bass guitar (2013–)
Gustaf "ThorBo" Bodén – drums (2013–)
Jonas "STORM" Blomqvist – guitar (2013–)

Former
Denis "Chek" Rybakov – bass guitar (2002–2013)
Nikita Alekseev – guitar (2006–2013)
Serj Yashin – drums (2011–2013)
Serj Kulikov – drums (2005–2011)
Dmitriy Kurin – drums (2002–2005)

References

Musical groups established in 2002
Russian nu metal musical groups
Lundzi is a town in western Eswatini. It is located close to the border with South Africa, 25 kilometres west of the capital, Mbabane.

References
Fitzpatrick, M., Blond, B., Pitcher, G., Richmond, S., and Warren, M. (2004)  South Africa, Lesotho and Swaziland. Footscray, VIC: Lonely Planet.

Populated places in Eswatini
The Joe Pell Building, also known as The Hub, on Pell St. in Lewisport, Kentucky, was listed on the National Register of Historic Places in 1984.

It was deemed significant as "the only intact late 19th century wood frame commercial building in Lewisport, and one of few which
exist, intact in the state. It is a fine representative example of a once popular vernacular commercial building."

The building is no longer on the site.

References

Commercial buildings on the National Register of Historic Places in Kentucky
National Register of Historic Places in Hancock County, Kentucky
Former buildings and structures in Kentucky
The Tampere Central Fire Station () is a fire station located at Satakunnankatu 16 in the Jussinkylä, Tampere, Finland, on the eastern shore of Tammerkoski. The Art Nouveau-style fire station building, completed in 1908, was designed by architect Wivi Lönn.

History
A permanent fire brigade was established in Tampere on 5 July 1898, and a voluntary fire brigade had been established in the city as early as 1873. The permanent fire brigade initially operated in temporary premises in the merchant Axel Siren's house at Puutarhakatu 6. A estate of land was built for the building along Satakunnankatu in 1903, and in 1905 a fire station design competition was held, which was won in February 1906 by architect Wivi Lönn. The Malmö's fire station in Sweden must have been used as an example in the design of the fire station.

Design and construction
The station was originally designed for horse-drawn equipment and the horse stables and equipment hall were located in the curved center of the station. Architect Berndt Blom, who acted as Tampere's firefighter, also contributed to the functional design of the station. Construction work on the fire station began in April 1907 and the building was commissioned on September 30, 1908. Completion of the building was delayed by four months on the construction site on Christmas Eve 1907 due to a fire that broke out. The building was made of brick but also used reinforced concrete structures. The facades were upholstered in granite. The fire station also included a fire tower.

In the 1920s, alterations were carried out at the fire station according to the plans of Tampere city architect Bertel Strömmer, when cars replaced horse-drawn equipment. In this context, the curved central part of the building was also raised by one floor, which was occupied by crew quarters. In 1982, a red-brick annex was completed for the fire station on the Palokunnankatu side and then for the fire station's so-called the old part was renovated in 1983–1986.

Museum

The Tampere Fire Museum (), founded in 1998, is located in the basement of the Central Fire Station. The renovated fire museum was opened to the public on the 2019 Tampere Day.

References

External links

Tampere Central Fire Station at Visit Tampere (in Finnish)
Tampere Central Fire Station at Virtual Tampere

Buildings and structures by Finnish architects
Buildings and structures in Tampere
Emergency services in Finland
Fire stations completed in 1908
Jussinkylä
Tourist attractions in Tampere
La Valletta Brianza (Brianzöö:  ) is a comune in the province of Lecco, Lombardy, northern Italy. It was created on 30 January 2015 when the two former communes o Perego and Rovagnate merged. The communal seat is located in the latter hamlet.

It is located about  northeast of Milan and about  south of Lecco.

References
High-resolution schemes are used in the numerical solution of partial differential equations where high accuracy is required in the presence of shocks or discontinuities. They have the following properties:

Second- or higher-order spatial accuracy is obtained in smooth parts of the solution.
Solutions are free from spurious oscillations or wiggles.
High accuracy is obtained around shocks and discontinuities.
The number of mesh points containing the wave is small compared with a first-order scheme with similar accuracy.

General methods are often not adequate for accurate resolution of steep gradient phenomena; they usually introduce non-physical effects such as smearing of the solution or spurious oscillations. Since publication of Godunov's order barrier theorem, which proved that linear methods cannot provide non-oscillatory solutions higher than first order (, ), these difficulties have attracted much attention and a number of techniques have been developed that largely overcome these problems. To avoid spurious or non-physical oscillations where shocks are present, schemes that exhibit a Total Variation Diminishing (TVD) characteristic are especially attractive. Two techniques that are proving to be particularly effective are MUSCL (Monotone Upstream-Centered Schemes for Conservation Laws), a flux/slope limiter method (, , , , ) and the WENO (Weighted Essentially Non-Oscillatory) method (, ). Both methods are usually referred to as high resolution schemes (see diagram).

MUSCL methods are generally second-order accurate in smooth regions (although they can be formulated for higher orders) and provide good resolution, monotonic solutions around discontinuities. They are straightforward to implement and are computationally efficient.

For problems comprising both shocks and complex smooth solution structure, WENO schemes can provide higher accuracy than second-order schemes along with good resolution around discontinuities. Most applications tend to use a fifth order accurate WENO scheme, whilst higher order schemes can be used where the problem demands improved accuracy in smooth regions.

The method of holistic discretisation systematically analyses subgrid scale dynamics to algebraically construct closures for numerical discretisations that are both accurate to any specified order of error in smooth regions, and automatically adapt to cater for rapid grid variations through the algebraic learning of subgrid structures ().  A web service analyses any PDE in a class that may be submitted.

See also
Godunov's theorem
Sergei K. Godunov
Total variation diminishing
Shock capturing method

References

 translated US Joint Publ. Res. Service, JPRS 7226, 1969.

Numerical differential equations
Computational fluid dynamics
Horsetail milkweed is a common name for several plants and may refer to:

Asclepias subverticillata
Asclepias verticillata
Luigi Giorgi (born 19 April 1987) is an Italian footballer who plays as a midfielder for Mantova.

Club career
Giorgi, started his professional career with Ascoli). In the 2006/2007 season Ascoli loaned him to Foligno on Serie C2 with 26 appearances. In the 2007 season Giorgi return on Serie B with Ascoli.

In 2011, he was sold to Novara for an undisclosed fee. On 16 January 2012 he transferred on loan to Siena in Serie A.
On 30 August 2012, he moved on loan to Palermo in exchange for Swedish striker Agon Mehmeti. He returned to Novara in January, but left again, this time to Atalanta.

On 9 July 2013, Atalanta signed Giorgi after a successful loan spell.

On 8 January 2019, he signed with Teramo. On 12 April 2019, he terminated his contract with the club.

References

External links
Career profile (from aic.it)

Living people
1987 births
Sportspeople from Ascoli Piceno
Men's association football midfielders
Italian men's footballers
Serie A players
Serie B players
Serie C players
Ascoli Calcio 1898 FC players
ASD Città di Foligno 1928 players
Novara FC players
ACR Siena 1904 players
Palermo FC players
Atalanta BC players
AC Cesena players
Spezia Calcio players
SSD Città di Teramo players
Mantova 1911 players
Footballers from Marche
Surahammar ( or ) is a locality and the seat of Surahammar Municipality in Västmanland County, Sweden with 6,179 inhabitants in 2010.

History 
During the reign of Gustav Vasa, there was a hammer in Surahammar. However, it is not known when the operation started, but it must have been before the year 1561.In 1637, a hammer with two hearths was erected by Axel Oxenstierna on the site where the current mill is located. In 1866, railway wheels and axles began to be manufactured and have been an important part of production ever since.

Towards the end of the 19th century, the sale of railway material declined. The mill's subsidiary Vagnfabriks-Aktiebolaget in Södertälge (Vabis) was therefore looking for new products to sell. The newly hired engineer Gustaf Erikson was sent on a study trip to Europe and back in Surahammar he built Sweden's first internal combustion engine driven car, which was his own construction with a kerosene engine. Vabi's first car for sale hit the market in 1901.

Culture and sights 
Hembygdsgården contains historic buildings with objects, serving all year round at events. 

The stone house is used for art exhibitions and is also the start and finish of the 2.5 km "historical walk" with information boards with unique historical images.

The Golden Wheel MC Museum, Surahammar contains, in addition to motorcycles and bicycles, a drivable replica of Sweden's first car, Gustaf Eriksson's carriage from 1897. The museum building has unique murals. Surahammar's mills museum shows the production chain from pig iron to railway wheels.

References 

Municipal seats of Västmanland County
Swedish municipal seats
Populated places in Västmanland County
Populated places in Surahammar Municipality
Sara Errani and Bibiane Schoofs were the defending champions, but Errani was unable to participate due to her doping suspension. Schoofs played alongside Desirae Krawczyk, but lost in the first round to Han Xinyun and Darija Jurak.

Eugenie Bouchard and Sofia Kenin won the title, defeating Paige Mary Hourigan and Taylor Townsend in the final, 1–6, 6–1, [10–7].

Seeds

Draw

Draw

External links
 Main draw

ASB Classic - Doubles
WTA Auckland Open
Muskoka was a federal electoral district represented in the House of Commons of Canada from 1872 to 1882 and from 1904 to 1925. It was located in the province of Ontario. 

This riding was first created from part of Victoria North and from areas that until then were unrepresented.

It initially consisted of the Townships of Morrison, Ryde, Muskoka, Draper, Oakley, Wood, Monck, Macauley, McLean, Medora, Watt, Stephenson, Brunel, Humphrey, Cardwell, Stisted, Chaffey, Christie, Monteith, McMurrich, Matchitt, Ryerson, Spence, McKellar, McDougall, Ferguson, Carling, Hagerman, Croft, Chapman, Ferrie, Mackenzie, Wilson, Brown, Blair, Mowat Cowper, Conger, Parry Island, Parry Sound, Aumick Lake Territory, Maganetawan, and all other surveyed townships lying north of the North Riding of Victoria, and south of the Nipissing District.

The electoral district was abolished in 1882 when it was redistributed between Muskoka and Parry Sound, Ontario North and Simcoe East ridings. 

It was re-created in 1903 from Muskoka and Parry Sound riding, and consisted of the territorial district of Muskoka.

The electoral district was abolished in 1924 when it was merged into Muskoka—Ontario riding.

Members of Parliament

This riding has elected the following Members of Parliament:

Election history

1872–1882

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1903-1924

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See also 

 List of Canadian federal electoral districts
 Historical federal electoral districts of Canada

External links 
 Library of Parliament website: 1872 to 1882
 Library of Parliament website: 1904 to 1925

Former federal electoral districts of Ontario
Laxon is a surname. Notable people with the surname include:

Herbert Laxon (1881–1965), English rugby union player
Sheila Laxon, Welsh horse trainer

See also
LaVon (given name)
John Carr (26 November 1892 – 10 May 1942) was an English professional footballer. He made 449 league appearances for Middlesbrough, scoring 81 times. He was also capped twice for England.

Playing career

Club career
Born in South Bank, near Middlesbrough, Carr signed a professional contract with his hometown club on 25 January 1911, after having already played as an amateur. He had four brothers, all of whom played for Middlesbrough: Walter and Harry, who signed as amateurs, and Willie and George, who both signed professional contracts for the club.

His debut came on 2 January 1911 against Nottingham Forest in a 2–2 draw. Carr scored both goals in front of a crowd of 15,000. That was the only appearance he made that season, his next game not coming until 27 January 1912. He made only three further appearances that season, scoring one goal.

Carr made his mark the following season with 16 goals in 30 appearances, before going on to score 59 further times for Middlesbrough.

After 20 years of service to Middlesbrough, Carr was transferred to Blackpool on 14 May 1930, for the sum of £500. He spent a season at Blackpool before moving on to Hartlepools United in 1931, firstly as player/coach and retired as a player in 1932.

International career
Carr was capped twice for England. His debut, against Ireland in Belfast on 25 October 1919, ended in a 1–1 draw, and his second and final cap came four years later against Wales at Cardiff on 5 March 1923. The game finished 2–2.

Managerial career
Carr started his managerial career as a player/coach at Hartlepools United in 1931. He took over as manager in 1932.

Carr was subsequently manager at Tranmere Rovers (1935–1936) and Darlington (1938–1942).

References

External links 

England profile

1892 births
People from South Bank, Redcar and Cleveland
1942 deaths
English men's footballers
Middlesbrough F.C. players
Blackpool F.C. players
Hartlepool United F.C. players
England men's international footballers
English football managers
Hartlepool United F.C. managers
Tranmere Rovers F.C. managers
Darlington F.C. managers
English Football League players
English Football League representative players
English Football League managers
South Bank F.C. players
Footballers from Yorkshire
Brentford F.C. wartime guest players
Men's association football wing halves
Hartlepool United F.C. non-playing staff
In Scots law, jus relictae is the right of the surviving spouse in the moveable property of the deceased spouse. Jus relictae is the term used for a surviving wife, and jus relicti is the term used for a surviving husband. The similar right for any surviving children is referred to as legitim.

The deceased must have been domiciled in Scotland, but the right accrues from moveable property, wherever situated. The surviving spouse's right vests by survivance, and is independent of the deceased spouse's testamentary provisions; it may however be renounced by contract, or be discharged by satisfaction. It is subject to alienation of the deceased spouse's moveable property during his lifetime or by its conversion into heritable property.

Additional explanations
Prior to 1964 the surviving spouse also has a right of terce (not the same as the religious term terce) on the deceased spouse's lands. Thus, under Scots law, both moveable and heritable property were subject to the rights of a surviving spouse and children. However, section 10(1) of the Succession (Scotland) Act 1964 abolished the common law rights of 'terce' and 'courtesy'. Only jus relictae, jus relicti and legitim remain.

The legal principles of jus relictae and legitime also remain active in the US state of Louisiana, which differs from the other 49 states as it operates under a civil law code similar to the Napoleonic code and Roman law rather than common law.

References

Latin legal terminology
Scots law legal terminology
Herman Wrangel (born 1584/1587 – 10 December 1643) was a Swedish military officer and statesman of Baltic German extraction.

Biography
Herman von Wrangel was born in Livonia. He came to Sweden around 1608. In 1612, he participated in the Kalmar War against Denmark. In 1619,  Wrangel was commander of Älvsborg fortress. He was appointed Field Marshal in 1621, Privy Councillor in 1630, and Governor General of Swedish Livonia in 1643.

Wrangel was married three times. In 1636, he married Amalie of Nassau-Siegen, daughter of John VII, Count of Nassau-Siegen. He was the father of statesman and military commander Carl Gustaf von Wrangel (1613–1676).

See also
Wrangel family
Polish-Swedish War

References

Other Sources
 Wrangel, 1. Herman, "Nordisk familjebok" (2nd edition, 1921)

External links

1580s births
1643 deaths
Field marshals of Sweden
Governors-General of Sweden
Members of the Privy Council of Sweden
17th-century Swedish nobility
Baltic-German people
17th-century Swedish military personnel
People from Põltsamaa
17th-century Swedish politicians
Herman