Samantha912/NLP_A2_WTH huggingface dataset:
Icotinib (trade name Conmana) is a highly selective, first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Icotinib is approved for use in China as first-line monotherapy in patients with non-small-cell lung cancer with somatic EGFR mutations.

Development
Icotinib was first synthesized in 2002 by the company Betta Pharma. The US patent application for the preparation of icotinib and icotinib hydrochloride was filed on December 28, 2012, and granted on July 21, 2015.

Mechanism of action
Icotinib is a quinazoline derivative that competitively inhibits the ATP binding site of the EGFR receptor protein. EGFR drives malignant growth of cells when mutations occur within the tyrosine kinase domain of this protein. Such mutations cause unchecked cell proliferation, which inappropriately activates the anti-apoptotic Ras signaling pathway. By blocking the binding of ATP to EGFR, icotinib prevents activity of the signal transduction cascade that initiates mitosis.

Indications 
Icotinib is approved in China for the treatment of non-small cell lung cancer in patients with an EGFR mutation who have advanced or metastatic disease.

Clinical research
The ICOGEN trial was a double-blind, head-to-head phase III study comparing icotinib with gefitinib in 399 patients across 27 centers in China. Results showed icotinib to have a median progression-free survival of 4.6 months (95% CI 3.5 – 6.3) as compared to gefitinib which has a PFS of 3.4 months (95% CI 2.3 – 3.8). Post-hoc analysis found fewer adverse events with icotinib than gefitinib (61% versus 70% respectively, p = 0.046).

The ISAFE trial was a phase IV study evaluating the safety and toxicity of icotinib in 5,549 patients. It showed an overall adverse event rate of 31.5% and response rate of 30% to the drug.

After receiving approval from the FDA to study icotinib in NSCLC patients, a phase 1 study was planned to be conducted at Roswell Park Comprehensive Cancer Center in New York State, however the trial was withdrawn prior to enrollment. No further pursuits of US-based studies of icotinib have transpired since.

Regulatory approvals
Icotinib was approved in China by the SFDA in June, 2011. An indication for icotinib was approved in China by the SFDA in November 2014 as first-line treatment for patients with advanced-stage NSCLC with EGFR mutation.

References 

Tyrosine kinase inhibitors
Quinazolines
Candice Henrietta Scott (born 17 September 1980) is a track and field athlete who is a hammer throw specialist from Trinidad and Tobago.

Her personal best throw is 71.45 metres, achieved in May 2005 in Marietta, Georgia.

She attended the University of Florida in Gainesville, Florida, where she was a member of the Florida Gators track and field team.  She graduated from the university with a bachelor's degree in recreation in 2005.

Achievements

See also 

 Florida Gators
 List of University of Florida alumni
 List of University of Florida Olympians

References 

 

1980 births
Living people
Athletes (track and field) at the 2003 Pan American Games
Athletes (track and field) at the 2004 Summer Olympics
Athletes (track and field) at the 2008 Summer Olympics
Florida Gators women's track and field athletes
Olympic athletes for Trinidad and Tobago
Trinidad and Tobago hammer throwers
Female hammer throwers
Trinidad and Tobago female athletes
Pan American Games medalists in athletics (track and field)
Pan American Games bronze medalists for Trinidad and Tobago
Female weight throwers
Medalists at the 2003 Pan American Games
Athletes (track and field) at the 2002 Commonwealth Games
Commonwealth Games competitors for Trinidad and Tobago
Trinidad and Tobago shot putters
Martha Alice "Mattie" Howard (November 1894–November 13, 1984?) was a high profile American, convicted criminal who became part of the Kansas City, Missouri underworld in the early part of the 20th-century. Through her participation in criminal activity, Howard became a celebrity.  She served six years and six months in the Missouri State Penitentiary after being convicted on the charge of 2nd degree murder. Upon release she became an evangelist, traveling throughout the United States sharing her life story.

Biography 
Mattie was born in Preston, Idaho in November 1894 the daughter of Charles P. (b. 1860) and Mattie (nee Keenan) Howard (b. 1867). She was raised in the Denver, Colorado area.

Charles was frequently absent from the home during her childhood and formative years. There were many times when coal for heating and food were in short supply. Conflict at home with her brothers eventually caused her to flee to Limon, Colorado where she worked in the Limon depot and Grier House at around the age 17. For this work she received $12.00 per week, plus tips, along with free room and board. Becoming homesick, she returned home only to be pursued by a suitor which caused her to disappear again.

On the night of December 8, 1914, Mattie's brother Robert (Oliver Robert, or O.B., as he was called), Albert C. Pagel, Jr. and a third man robbed the United States Post Office in Walsenburg, Colorado.  $15,000 USD, which was supposed to go to the local bank went missing in that robbery. They committed this crime while stationed with the Cavalry, in Walsenburg, during the unrest in the coal fields of that period.  

She was accused of murdering Kansas City pawnbroker and diamond dealer Joseph Morino on May 23, 1918. Morino was found at the Touraine Hotel, 1412 Central Street. He had been killed by a blow to the head.

The downward spiral of her life continued with the death of Pagel from septic peritonitis. The sepsis was due to gunshots receiving during another criminal activity. He died on March 14, 1920, at age 28.

Howard enlisted the services of Kansas City attorney Jesse James Jr., son of the notorious outlaw. She fled Missouri in her efforts to avoid a prison term. Howard was captured in Memphis, Tennessee and returned to Kansas City for trial.

Howard was convicted at trial of second degree murder in the death of Morino. She was sentenced to the Missouri State Penitentiary where she served 7 years.

After her release from prison on May 17, 1928. She claimed in newspapers to have then moved to Chicago where she became part of Al Capone's mob, mostly their driving cars; until she grew restless and left the life of crime when she found her religious calling on September 15, 1932. She became an evangelist and shared her story with many groups across the United States.

References 

1894 births
People from Preston, Idaho
Date of death unknown
Serampore (previously known as Serampore-26 and changed to Srerampur-27 in the 2009 election) is one of the 543 Lok Sabha (parliamentary) constituencies in India. The constituency centres on Serampore in West Bengal. Five assembly segments of the constituency are in Hooghly district and two are in Howrah district.

Overview

Srerampur is basically an industrial constituency with an agricultural hinterland. The Howrah-Hooghly industrial belt on the west bank of the Hooghly river covers the Howrah, Hooghly and Srerampur constituency.

According to The Hindu, Serampore and Howrah constituencies have more than 25% non-Bengali voters with their roots in Rajasthan, Bihar or Uttar Pradesh.

Vidhan Sabha segments
As per order of the Delimitation Commission issued in 2006 in respect of the delimitation of constituencies in the West Bengal, parliamentary constituency no. 27 Sreerampur is composed of the following segments:

Prior to delimitation Serampore Lok Sabha constituency was composed of the following assembly segments:Jagatballavpur (assembly constituency no. 167), Panchla (assembly constituency no. 168), Jangipara (assembly constituency no. 177), Chanditala (assembly constituency no. 178), Uttarpara (assembly constituency no. 179), Sreerampur(assembly constituency no. 180), Champdani (assembly constituency no. 181)

Members of Parliament

Runner-up Info 1951-2019
Most of the contests were multi-cornered. However, only winners and runners-up are mentioned below:

Election results

General election 2019

General election 2014

General election 2009

General election 2004

General election 1999

General election 1998

General election 1996

General election 1991

General election 1989

General election 1984

By-election 1981 
A by-election was held in this constituency in 1981 which was necessitated by the Death of sitting MP Dinen Bhattacharya.In the by-election, Ajit Bag of CPIM defeated his nearest rival S.M Roy of Congress by 96,549 votes.

General election 1980

See also
 List of constituencies of the Lok Sabha

References

External links
Sreerampur lok sabha  constituency election 2019 result details

Lok Sabha constituencies in West Bengal
Politics of Hooghly district
Thomas R. Olsen  (June 28, 1934 – January 5, 2014) was a major general in the United States Air Force.

Biography
Olsen was born in Houston, Texas, in 1934. He died on January 5, 2014, at the age of 79.

Career
Olsen completed Squadron Officer School in 1964, Naval Command and Staff College in 1968, and Air War College in 1975. Olsen, from June 1983 to July 1985 was assigned to Headquarters U.S. Pacific Command, Camp H.M. Smith, Hawaii, as deputy director for operations. He then served as assistant chief of staff for operations, Allied Forces Central Europe, Brunssum, Netherlands. In October 1987 he became chief of staff and deputy commander, 4th Allied Tactical Air Force, Heidelberg, West Germany. His retirement was effective as of November 1, 1991.

Awards he received include the Defense Superior Service Medal, Legion of Merit, Distinguished Flying Cross, Meritorious Service Medal with two oak leaf clusters, Air Medal with 15 oak leaf clusters, and Air Force Commendation Medal.

References

1934 births
2014 deaths
Military personnel from Houston
Recipients of the Air Medal
Recipients of the Distinguished Flying Cross (United States)
Recipients of the Legion of Merit
Recipients of the Defense Superior Service Medal
Gabriel Virgil Florea (born July 12, 1985) is a Romanian football defender who plays for German lower leagues side FSV Offenbach. Since he was a boy, Florea played for important Liga I teams in Romania such as FCU Craiova (in 2004 and 2005, as a midfield), and Jiul Petroșani, in 2006-07 Liga I season.

At only 18, he was already holder in most of the games he played.
In 2007, he has ranked 5th with 5.76 points on a Jiul Petroșani forum.

Since 2007 to 2009, he played almost 100 games in Second League of Romania.

References
 http://www.romaniansoccer.ro/clubs/universitatea_craiova/u_craiova_2004_05.shtml
 http://www.romaniansoccer.ro/clubs/jiul_petrosani/jiul_petrosani_2006_07.shtml
 https://web.archive.org/web/20110720181149/http://www.servuspress.ro/hd/articol.php?id=13955

1985 births
Living people
Footballers from Craiova
Romanian men's footballers
Men's association football midfielders
Liga I players
Liga II players
FC U Craiova 1948 players
CSM Jiul Petroșani players
CSM Deva players
CSM Reșița players
Romanian expatriate men's footballers
Romanian expatriate sportspeople in Germany
Expatriate men's footballers in Germany
FC Unirea Dej players
Omitlán de Juárez is a town and one of the 84 municipalities of Hidalgo, in central-eastern Mexico. The municipality covers an area of 110.5 km².

As of 2005, the municipality had a total population of 7,529.

References

Municipalities of Hidalgo (state)
Populated places in Hidalgo (state)
Schizothorax eurystomus is a species of ray-finned fish in the genus Schizothorax.

References 

Schizothorax
Fish described in 1872
Seikphyu () is the principal town and administrative seat for Seikphyu Township in Pakokku District in the Magway Division of Myanmar, on the right (western) bank of the Irrawaddy immediately below its confluence with the Yaw River. It is located across the Irrawaddy river from Chauk and is connected by Anawrahta Bridge. It is situated 34 kilometers south-south-west of ancient Bagan City and 44 kilometers from Nyaung U Airport.

Notes

External links
 
 "Seikpyu Map — Satellite Images of Seikpyu" Maplandia World Gazetteer

Populated places in Magway Region
Township capitals of Myanmar
Dallas Thornton (born September 1, 1946) is an American former basketball player.

Biography
Thornton was born in Louisville, Kentucky and played basketball at Male High School there.

Thornton played college basketball at Kentucky Wesleyan College.

Thornton was selected in the 1968 NBA draft in the fourth round by the Baltimore Bullets and was selected in the 1968 ABA draft by the Miami Floridians.   Thornton opted to sign with the Floridians and played for the team through two seasons, averaging 6.6 points per game in the 1968–69 season and 8.8 points per game in 1969–70.

Thornton then played for the Harlem Globetrotters and appeared in the 1981 movie The Harlem Globetrotters on Gilligan's Island.

References

1946 births
Living people
American men's basketball players
Baltimore Bullets (1963–1973) draft picks
Harlem Globetrotters players
Kentucky Wesleyan Panthers men's basketball players
Louisville Male High School alumni
Miami Floridians draft picks
Miami Floridians players
Small forwards
Basketball players from Louisville, Kentucky
The Woshan WS-6 was an unsuccessful turbofan development program from the People's Republic of China.

Development started as part of the "Aviation Industry Science and Technology Development Program for 1978-1985" with the larger goal of developing an industry capable of designing and building aircraft engines. No workable engines were produced when the program was cancelled in 1986.

Experience from the WS-6 was applied to the later Shenyang WS-10.

References

Low-bypass turbofan engines
1970s turbofan engines
Glen Carbon Village Hall and Firehouse is a historic building at 180 Summit Avenue in Glen Carbon, Illinois. It was built in 1910 to serve as Glen Carbon's first village hall. The village was founded in 1892, and its government met in various businesses and public buildings until the village's growth necessitated a permanent building. The Oswald Brothers of nearby Alhambra built the Neoclassical building. The village government occupied the upper level of the building, while its fire department used the lower level. The village hall was the site of several contentious events in the 1910s; one village trustee won a tied election by pulling a number from a hat, and village president Hiram Slinger, Jr., had his nominees for village treasurer unanimously rejected by the trustees seventeen times. The village government moved to the former Glen Carbon Grade School in 1954, and the fire department moved to a new firehouse in 1981; the building is now used as meeting space by a model railroad club and a local Boy Scout troop.

The building was added to the National Register of Historic Places on April 19, 2018.

References

National Register of Historic Places in Madison County, Illinois
Government buildings on the National Register of Historic Places in Illinois
Neoclassical architecture in Illinois
Government buildings completed in 1910
Ethyl carfluzepate is a drug which is a benzodiazepine derivative. It is similar to ethyl loflazepate in chemical structure, the other difference being an absence of methylcarbamoyl group. Its properties are mainly sedative and hypnotic.

References

Benzodiazepines
Chloroarenes
Fluoroarenes
Lactams
Ureas
Ethyl esters
GABAA receptor positive allosteric modulators
Heath High Level railway station is one of two railway stations serving Heath, Cardiff, Wales. The station is located on the Rhymney Line. Passenger services are provided by Transport for Wales as part of the Valley Lines network.

It was opened by the Rhymney Railway in 1915. The Low Level station is located on the Coryton Line.

Services
The station has a basic weekday service of 4 departures each way per hour - northbound to  (with hourly extensions to ) and southbound to  and . This drops to half-hourly in the evenings and to two-hourly on Sundays (when southbound trains run to ).

See also
 Heath Low Level railway station
 List of railway stations in Cardiff

Notes

External links
Video footage of Heath High Level

Railway stations in Cardiff
DfT Category F2 stations
Former Rhymney Railway stations
Railway stations in Great Britain opened in 1915
Railway stations served by Transport for Wales Rail
Mastax rugiceps is a species of beetle in the family Carabidae with restricted distribution in Myanmar.

References

Mastax rugiceps
Beetles of Asia
Beetles described in 1892
Véronique Ançay-Carron, née Ançay (born 1970), from Fully is a Swiss ski mountaineer. She also takes part in mountain bike and ultramarathon competitions.

Selected results 
 2000:
 1st, Patrouille de la Maya A-course, together with Nicole Gillioz and Christine Luyet
 2001:
 1st, Tour du Rutor (together with Catherine Mabillard)
 3rd, Trophée des Gastlosen (European Cup, together with Christine Luyet)
 7th, European Championship team race (together with Christine Luyet)
 2002:
 1st, Patrouille de la Maya A-course, together with Catherine Mabillard and Anne Bochatay
 1st, Diamir Race Diemigtal Swiss Cup race (together with Catherine Mabillard)
 3rd, Valerette Altiski 2000 Swiss Cup race 
 2004:
 1st, Patrouille de la Maya A-course, together with Chantal Daucourt and Mary-Jérôme Vaudan
 2008:
 1st, Patrouille de la Maya A-course, together with Mary-Jérôme Vaudan and Anne Bochatay
 2009:
 3rd, Trophée des Gastlosen (together with Valérie Berthod-Pellissier)

Patrouille des Glaciers 

 2002: 2nd, together with Nicole Gillioz and Christine Luyet
 2004: 3rd, together with Chantal Daucourt and Mary-Jérôme Vaudan
 2008: 5th (and 1st in the "civilian women" ranking), together with Anne Bochatay and Mary-Jérôme Vaudan
 2010: 6th (and 3rd in the "civilian women" ranking), together with Mary-Jérôme Vaudan and Valérie Berthod-Pélissier

Pierra Menta 

 1999: 4th, together with Catherine Mabillard
 2001, 3rd, together with Nicole Gillioz
 2005: 6th, together with Nathalie Blanc

Trofeo Mezzalama 

 2011: 10th, together with Valérie Berthod-Pellissier and Mary-Jérôme Vaudan

External links 
 Personnel website

References 

1970 births
Living people
Swiss female ski mountaineers
The Roman Catholic Diocese of Eséka () is a diocese located in the city of Eséka in the Ecclesiastical province of Douala in Cameroon.

History
 March 22, 1993: Established as Diocese of Eséka from the Metropolitan Archdiocese of Douala

Special churches
The cathedral is the Cathédrale Notre Dame de Fatima in Eseka.

Bishops
 Bishops of Eséka (Roman rite), in reverse chronological order
 Bishop François Achille Eyabi (November 14, 2020 -   )
 Bishop Dieudonné Bogmis (October 15, 2004  – August 25, 2018)
 Bishop Jean-Bosco Ntep (March 22, 1993  – October 15, 2004), appointed Bishop of Edéa

Other priest of this diocese who became bishop
Sosthène Léopold Bayemi Matjei, appointed Bishop of Obala in 2009

See also
Roman Catholicism in Cameroon

References

External links
 GCatholic.org

Roman Catholic dioceses in Cameroon
Christian organizations established in 1993
Roman Catholic dioceses and prelatures established in the 20th century
Roman Catholic Ecclesiastical Province of Douala
Close Combat: Marines is the first version of the Close Combat universe made specifically for military training purposes.  Forces consist of USMC and OpFor troops.  The game was first released in the September 2004, issue of the Marine Corps Gazette.

A commercial version for civilians was made called The Road to Baghdad.

Reception

References

2004 video games
Propaganda video games
Real-time tactics video games
Video games about the United States Marine Corps
Video games developed in the United States
Windows games
Windows-only games
Multiplayer and single-player video games
Atomic Games games
The Ranizai are a sub tribe of the Yusufzai Pashtun tribe in the Malakand District in North-West Frontier Province, Pakistan.
Ranizai tribe has occupied the upper part of district Malakand. The various important villages include Thana, Alladand Dheri, Batkhela, Khar, Dheri Julagram Totakan Mekhband Sholwai and Matkani. Alladand Dheri village was the head office. The various sub-tribes of Ranizai is Ali-khail. Ranizai is further divided into 5 sub-khels which are;
Mardan khel
Ismail khel
Umbarak khel
Dadi khel
kari khel 

Malakand District
Yusufzai Pashtun tribes
Oleg Balan (born 27 November 1969) is a Moldovan jurist and politician who served as Minister of Internal Affairs of Moldova between 18 February 2015 and 20 January 2016.

From December 2014 until 18 February 2015 Oleg Balan was a Member of Parliament of Moldova, before being appointed as Minister of Internal Affairs of Moldova in the Gaburici Cabinet, replacing Dorin Recean in office. He served as Minister of Interior also in the next cabinet led by Valeriu Streleț, until, after a political crisis, the Filip Cabinet was inaugurated on 20 January 2016.

Personal life
Oleg Balan is married and has two children. Aside Romanian he speaks Russian and French.

Publications
Oleg Balan is author or co-author of 84 works, researches and communiques scientific on his specialty:
Drept internațional public" (two volumes), 
Drept internațional umanitar",
Drept comunitar",
Drept internațional public" (2nd edition),
Drept international public" (3rd edition),
Terorismul - crima internațională", 
Terorism și antiterorism", 
Protecția drepturilor omului în conflictele armate".

References

1969 births
Living people
Moldovan Ministers of Internal Affairs
Moldovan generals
Moldovan politicians
Babeș-Bolyai University alumni
People from Cantemir District
Paul Giroud (6 June 1898 – 21 January 1989) was a French physician and biologist.

Biography
 
Born in Munet (Moulins), Allier, France he studied and worked at the Institut Pasteur in Paris.

Giroud was Head of Laboratory at the Institut Pasteur in Paris from 1930 to 1938. During these years he carried out several missions in Tunisia to research the source of typhus. 
Meanwhile, he also travelled to the USSR, where he met Vladimir Barykin, who had developed a method of cultivating the agent of typhus for the preparation of a vaccine.
In 1940 Giroud together with René Panthier developed a vaccine against typhus. After this discovery Giroud studied the rickettsioses in Congo, Rwanda, Kenya and Ethiopia. He also worked on a vaccine against Rocky Mountain spotted fever.

In 1956 he was elected member of the Académie de Médecine and in 1971 promoted to Commander of the Legion of Honour in the biological science section.

References

External links
 Biography at pathexo.fr
 Biography at Institut Pasteur

1898 births
1989 deaths
People from Allier
People from Moulins, Allier
Académie Nationale de Médecine
20th-century French biologists
20th-century French physicians
Chung may refer to:

Surnames
 Chung (surname)
 Jeong (surname), Korean surname
 Zhong (surname), or Chung, Chinese surname
 Cheung, or Chung, Cantonese surname

Geography
 Chung, Iran, a village in Kohgiluyeh and Boyer-Ahmad Province, Iran
 Chung, India, a village in Patti Tehsil, Amritsar, Punjab, India

Language
 Chung language of Cameroon.

See also
 Chan (disambiguation)
 Chong (disambiguation)
 Zhong (disambiguation)