Samantha912/NLP_A2_WTH huggingface dataset:
Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene.

Function
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABAA receptor. At least 16 distinct subunits of GABAA receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.

Subunit selective ligands
Recent research has produced several ligands which are moderately selective for GABAA receptors containing the α5 subunit. These have proved to be useful in investigating some of the side effects of benzodiazepine and nonbenzodiazepine drugs, particularly the effects on learning and memory such as anterograde amnesia. Inverse agonists at this subunit have nootropic effects and may be useful for the treatment of cognitive disorders such as Alzheimer's disease.

Agonists
 QH-ii-066
 SH-053-R-CH3-2′F

Antagonists
 α5IA
 Basmisanil (RG-1662, RO5186582): derivative of Ro4938581, negative allosteric modulator at GABAA α5, in human trials for treating cognitive deficit in Down syndrome.
 L-655,708
 MRK-016
 PWZ-029: moderate inverse agonist
 Pyridazines
 Ro4938581
 TB-21007

See also
 GABAA receptor

References

Further reading

External links
 

Ion channels
Biology of bipolar disorder
Alexander Craig may refer to:

 Alexander Craig (poet) (1567?–1627), Scottish poet
 Alexander Kerr Craig (1828–1892), American politician
 Alexander J. Craig (1823–1870), American educator and politician from Wisconsin
 Alex Craig (footballer) (1886–?), Irish footballer
 Alex Craig (rugby union) (born 1998), Scottish rugby union player 
 Alexander George Craig (1897–1973), author and poet

See also
Gladys “Sandy” Dorador Inga (born 4 January 1989) is a Peruvian footballer who plays as a forward for Sporting Cristal and the Peru women's national team.

International career
Dorador represented Peru at the 2006 South American U-20 Women's Championship. At senior level, she played the 2006 South American Women's Football Championship and the 2019 Pan American Games.

International goals
Scores and results list Peru's goal tally first

References

External links

1989 births
Living people
Women's association football forwards
Peruvian women's footballers
Footballers from Lima
Peru women's international footballers
Pan American Games competitors for Peru
Footballers at the 2019 Pan American Games
Sporting Cristal (women) players
Peruvian women's futsal players
Cereals are grasses cultivated for the edible components of their grain. 

Cereal may also refer to:

Breakfast cereal
an adjective referring to the goddess Ceres
cereals and pseudocereals collectively
Caryopsis
Food grain
Cereal (magazine), a UK travel and style magazine
Cereal, Alberta, Canada
"Cereal," an episode from the 20th season of Arthur

See also
Cereals Event which takes place in the UK
Cerean (disambiguation)
Ceres (dwarf planet)
Serial (disambiguation)
Al-Suqaylabiyah District ( ) is a district (mantiqah) administratively belonging to Hama Governorate, Syria. At the 2004 official census, the district had a population of 240,091. Its administrative centre is the city of Al-Suqaylabiyah. The district includes most of Al-Ghab plain.

Sub-districts
The district of Hama is divided into five sub-districts or nahiyahs (population according to 2004 official census):
Al-Suqaylabiyah Subdistrict (ناحية السقيلبية): population 49,686.
Tell Salhab Subdistrict (ناحية تلسلحب): population 38,783.
Al-Ziyarah Subdistrict (ناحية الزيارة): population 38,872.
Shathah Subdistrict (ناحية شطحة): population 25,273.
Qalaat al-Madiq Subdistrict (ناحية قلعة المضيق): population 85,597.

References

 
Al-Ghab Plain
Constantine Bay (, meaning church of St Constantine) is a village and beach on the Atlantic coast of north Cornwall, England, United Kingdom. It is situated  approximately three miles (5 km) west of Padstow and is in the parish of St Merryn. The beach is sandy and is popular with surfers and has lifeguard patrols in the summer. Historically the sand was removed by local farmers by horse and cart to spread on the land to lighten and fertilise the heavy soil.

Constantine Bay is named after Saint Constantine, a 6th-century Cornish saint possibly identified with a minor British king Constantine. St Constantine's Well, an historic site, is accessible by public right of way on Trevose Golf Club's golf course. The area was a favourite holiday location of Margaret Thatcher during her premiership and also of former Prime Minister David Cameron.

Trevose Head and Constantine Bay SSSI is designated for both its biological and geological interests. The dune system at Constantine Bay is in an unfavourable declining condition because of the invasion by species such as bramble, ivy and sea buckthorn; and by visitor pressure causing erosion.

Constantine Bay lies within the Cornwall Area of Outstanding Natural Beauty (AONB).

Other coastal villages nearby include Harlyn, Porthcothan, Trevone and Treyarnon

References

External links

Villages in Cornwall
Beaches of Cornwall
Bays of Cornwall
Populated coastal places in Cornwall
A MIS capacitor is a capacitor formed from a layer of metal, a layer of insulating material and a layer of semiconductor material. It gets its name from the initials of the metal-insulator-semiconductor (MIS) structure. As with the MOS field-effect transistor structure, for historical reasons, this layer is also often referred to as a MOS capacitor, but this specifically refers to an oxide insulator material.

The maximum capacitance, CMIS(max) is calculated analogously to the plate capacitor:

 
where :
εr  is the insulator's relative permittivity
ε0  is the permittivity of the vacuum
A is the area
d is the insulator thickness

The production method depends on materials used (it is even possible that polymers can be used as both the insulator or the semiconductor layers). We will consider an example of an inorganic MOS capacitor based on silicon and silicon dioxide. On the semiconductor substrate, a thin layer of oxide (silicon dioxide) is applied (by, for example, thermal oxidation, or chemical vapour deposition) and then coated with a metal.

This structure and thus a capacitor of this type is present in every MIS field-effect transistor, such as MOSFETs. For the steady reduction of the size of structures in microelectronics, the ever thinner insulation layers are required (to keep the same capacitance for smaller area). However when the oxide thickness falls below ~ 5 nm there arise parasitic leakages due to the tunneling effect. From this reason, the use of so-called high-κ dielectrics as the insulator material is being investigated. 

In the MOSFET R&D, the MIS capacitors are extensively used as a relatively simple testing bench, e.g. to examine fabrication process and properties of the novel insulator materials, to measure leakage currents and charge-to-breakdown, to get the trap density value, to verify different models for carrier transport. Furthermore the capacitors are often included in tutorial courses, particularly to discuss their charge states (inversion, depletion, accumulation) which also occur in the more complex transistor systems.

References

Capacitors
NGC 4451 is a spiral galaxy in the equatorial Virgo constellation. It was discovered at the Copenhagen Observatory on March 19, 1865 by Heinrich d'Arrest, who used an 11" refractor telescope. The galaxy is located at a distance of 85 million light years and is receding with a heliocentric radial velocity of 862 km/s. It is a member of the Virgo cluster of galaxies.

In March 1985, Shigo Horiguchi in Japan discovered a Type II-P supernova in this galaxy. Designated SN 1985G, it was positioned  west and  north of the galaxy center. The progenitor was estimated to have a mass of  and was  million years old.

References

External links 
 

4451
Virgo (constellation)
Unbarred spiral galaxies
041050
A pendhapa or pandhapa (Javanese: ꦥꦼꦤ꧀ꦝꦥ or ꦥꦤ꧀ꦝꦥ, Indonesian spelling: pendapa, nonstandard spelling: pendopo) is a fundamental  element of Javanese architecture unique in the southern central part of Java; a large pavilion-like structure built on columns. Either square or rectangular in plan, it is open on all sides and provides shelter from the sun and rain, but allows breeze and indirect light. The word pendhapa is cognate to the Sanskrit word mandapa ("hall").

The Dutch writer Multatuli in his colonial reformist novel Max Havelaar described the pendhapa thus: "After a broad-brimmed hat, an umbrella, or a hollow tree, a 'pendoppo' [sic] is certainly the most simple representation of the idea 'roof'."

Derived from ancient Javanese architectural elements, pendhapa are common ritual spaces primarily intended for ceremony, and also for a purposes such as receiving guests in the compounds of wealthy Javanese, and even as cottage industry work spaces. Pendhapa are constructed as a stand-alone structure or, attached to a walled inner structure (dalem), may form the front part of a traditional Javanese house (omah).

History

The oldest surviving images of ancient Javan vernacular architecture appear in Borobudur reliefs, among others the stepped roof type . They once sheltered the institutions of ancient Javanese kingdoms, such as law courts, clergy, palaces, and for public appearances of the king and his ministers. In 9th century Ratu Boko complex near Prambanan, there is traces of square elevated stone bases with , stones with hole to put wooden pillars on it. The similar structures also can be found in 14th century Trowulan dated from Majapahit era, where square brick bases with  stones suggest that some  once stood there. Because the pillars and the roof was made from wooden organic material, no trace of the  roof remains. The  with faithful Majapahit brick-base style can be found in 16th century Kraton Kasepuhan, Cirebon, as well as 17th century Kota Gede, Yogyakarta. This evidence suggests that the design has not changed much for over a millennia.

They remain fundamental components of Javanese kraton ('palaces'), with European influences often being incorporated since the 18th century. The majority of pendhapa are constructed from timber but masonry versions are in existence such as in the Kraton Kanoman in Cirebon. Wealthy modern day home builders, in attempting to design homes that draw on traditional Javanese experience of space, have dismantled, transported and re-assembled pendhapa to form modern-traditional hybrid homes. The pendhapa is used as a batik making place for women.

See also

 Javanese culture
 Kejawèn
 Joglo
 Indonesian architecture
 Kraton
 Zayat

References

 Schoppert, P., Damais, S., Java Style, 1997, Didier Millet, Paris, 207 pages, 

Architecture in Indonesia
Buri Nagar, commonly known as Burinagar, is a census village under Natun Dehar Gram Panchayat in Nalbari district, Assam, India. As per 2011 Census of India, the village has a total population of 2,555 people, including 1,344 males and 1,211 females, and has a literacy rate of 75.34%.

Burinagar has a history of being militancy affected area. At Burinagar, on 17 March 1999, the ULFA militants killed 3 youths in suspicion of being informers of police. On 5 January 2006, ex president of Nalbari block Congress Chand Muhammad Ali was killed by the NDFB militants at Burinagar.

References 

Assam
Jukebox is the debut studio album by American pop singer-songwriter Priscilla Renea. It was released on December 1, 2009. The album received positive reviews and spawned two singles: "Dollhouse", which garnered mild success, and "Lovesick".

Background
Six out of the eleven songs on the album were solely written by Renea. Renea wrote many songs like stories, by beginning with the verses and working on a chorus later, to make the songs more soulful and heartfelt. Renea performed many of the guitar and piano pieces of the songs herself. The album was originally due for an October 20, 2009, release but it was delayed by over a month for additional recording to occur for the album.

Critical reception
The album received generally positive reviews from critics. Ivan Mitchell of Prefixmag called the album "abstract", stating: "lead single 'Dollhouse' is the kind of sassy, exuberant pop/rock/R&B hybrid that Rihanna would have probably done earlier in her career". He went on to say that "'Fixing My Hair' finds common ground with the flashy torch soul productions of the 1980s".

Latifah Muhammad of ConcreteLoop stated that the album is "a delightful hybrid of poetic expression garnished with life lessons". She opined that "the theme of Jukebox revolves around the old saying 'you can catch more flies with honey than with vinegar' in that it manages to get a point across in a softer tone rather than boisterous and overbearing. Even though nothing really manages to ride above a steady boil, that's not always a bad thing. Jukebox is a pretty smooth ride null of any huge potholes or blunders, which is admirable and worth a good listen".

The album was also reviewed favorably in Billboard.

Promotion
Renea promoted the album by releasing an EP before the album. Hello My Apple was released on March 31, 2009, for digital download. However, Renea never performed live to promote the album, and only promoted the album with singles. However, Renea did release videos via YouTube to give her fans a sneak peek of the album's songs before its release.

Singles
 "Dollhouse" was released as the lead single from the album on August 18, 2009. The single reached number eleven on the Heatseekers singles chart, number thirty-one on the Hot Dance Club Songs chart and number thirty-four on the Pop Songs, becoming a mild chart success. A video was released in September 2009.
 "Lovesick" was released as the second and final single from the album on March 2, 2010. The single was promoted with videos of Renea singing the song with fans.

Track listing

References

2009 debut albums
Albums produced by Benny Blanco
Muni Long albums
Capitol Records albums
The Maestro, The Magistrate & The Mathematician is a novel written by Zimbabwean writer Tendai Huchu. Huchu's second novel, it was published in 2014 by Amabooks Publishers and republished by Parthian Books in 2015.

References 

2014 Zimbabwean novels
Novels by Tendai Huchu
Carlos Rodrigues Corrêa (born 29 December 1980) is a professional Brazilian footballer who plays as a defensive midfielder for Capivariano.

Club career
As many other Brazilian players, Corrêa was introduced to football on the streets of his city. After playing in various junior clubs, he was noticed by the scouts of Brazilian giants Palmeiras. After several successful seasons in Brazil, Corrêa was transferred to Europe, as he was noticed by Ukrainian top-flight club, FC Dynamo Kyiv.

He debuted for Dynamo in summer of 2006. Carlos wears the number 7 for Dynamo. Scoring three goals in his first three domestic league games for Dynamo, he quickly earned a starting spot in the Ukrainian team. Following Dynamo's 2–0 victory over domestic rival Shaktar Donetsk in the Ukrainian Super Cup, Shaktar's head coach Mircea Lucescu stated on Corrêa's performance that he is "an unbelievable midfielder". In Ukraine Correa proved himself as a master of corner and free kicks, and regularly performs them for his club.

In 2008 Correa suffered serious injury and missed some of the 2008–09 season. At that time Dynamo had changes at coaching position and the new coach Valeriy Gazzayev could find a place on a team for the Brazilian playmaker. In 2009 Correa lost his place in the first team and soon was loaned out.

In June 2010 Corrêa signed with Flamengo, on loan, for the rest of 2010 season.

On 30 July 2012 it was announced Corrêa would have a trial with Middlesbrough FC after being recommended to manager Tony Mowbray by club legend Juninho Paulista.

On 21 December 2012, after being relegated with Palmeiras, Corrêa was announced as player of Portuguesa de Desportos.

International career
There were talks of possible naturalization of him to play for the Ukraine national football team.

Flamengo career statistics
(Correct )

according to combined sources on the Flamengo official website and Flaestatística.

Honours
Campeonato Paulista Série A2: 2013

Dynamo Kyiv
Ukrainian Super Cup (2): 2006, 2009

References

External links

1980 births
Living people
Sportspeople from Limeira
Brazilian men's footballers
Brazilian expatriate men's footballers
Expatriate men's footballers in Ukraine
Campeonato Brasileiro Série A players
Sociedade Esportiva Palmeiras players
FC Dynamo Kyiv players
Clube Atlético Mineiro players
CR Flamengo footballers
Associação Portuguesa de Desportos players
Fortaleza Esporte Clube players
Ukrainian Premier League players
Brazilian expatriate sportspeople in Ukraine
Men's association football midfielders
Footballers from São Paulo (state)
Sainte-Eulalie-de-Cernon (; ) is a commune in the southern French department of Aveyron.

At the heart of the historic settlement is the Commandery of Saint Eulalia, a hospital (in the medieval sense of the word) established by the Order of the Knights Templar. After that Order was disbanded by Philip IV of France in 1307-08, royal forces were sent to close the hospital down, and from that event a detailed account of the buildings, their contents, both in the chapel and in the secular parts of the complex, and the life and customs of the occupants, has survived.

The Commandery came under the control of the Knights Hospitallers during the Hundred Years War and survived until its final destruction as a result of the French Revolution towards the end of the eighteenth century.

Many medieval buildings survive, together with later ones, inside high defensive walls.

Population

See also
Communes of the Aveyron department

Notes and references

Communes of Aveyron
Aveyron communes articles needing translation from French Wikipedia
In pharmacokinetics, the effective half-life is the rate of accumulation or elimination of a biochemical or pharmacological substance in an organism; it is the analogue of biological half-life when the kinetics are governed by multiple independent mechanisms. This is seen when there are multiple mechanisms of elimination, or when a drug occupies multiple pharmacological compartments.  It reflects the cumulative effect of the individual half-lives, as observed by the changes in the actual serum concentration of a drug under a given dosing regimen. The complexity of biological systems means that most pharmacological substances do not have a single mechanism of elimination, and hence the observed or effective half-life does not reflect that of a single process, but rather the summation of multiple independent processes.

Radionuclides
When radionuclides are used pharmacologically, for example in radiation therapy, they are eliminated through a combination of radioactive decay and biological excretion.  An effective half-life of the drug will involve a decay constant that represents the sum of the biological and physical decay constants, as in the formula:

With the decay constant it is possible to calculate the effective half-life using the formula:

The biological decay constant is often approximated as it is more difficult to accurately determine than the physical decay constant.

Alternatively, since the radioactive decay contributes to the "physical (i.e. radioactive)" half-life, while the metabolic elimination processes determines the "biological" half-life of the radionuclide, the two act as parallel paths for elimination of the radioactivity, the effective half-life could also be represented by the formula:

 , or.

External links 
 Biological Half-life

References

Pharmacokinetic metrics
In mathematics, a formal sum, formal series, or formal linear combination may be:
In group theory, an element of a free abelian group, a sum of finitely many elements from a given basis set multiplied by integer coefficients.
In linear algebra, an element of a vector space, a sum of finitely many elements from a given basis set multiplied by real, complex, or other numerical coefficients.
In the study of series (mathematics), a sum of an infinite sequence of numbers or other quantities, considered as an abstract mathematical object regardless of whether the sum converges.
In the study of power series, a sum of infinitely many monomials with distinct positive integer exponents, again considered as an abstract object regardless of convergence.
Zainool Maccum is a former West Indian cricket umpire. He stood in one ODI game in 1998.

See also
 List of One Day International cricket umpires

References

Year of birth missing (living people)
Living people
West Indian One Day International cricket umpires
Place of birth missing (living people)
The Violin Sonata No. 2 in E major, Op. 102, was written by Camille Saint-Saëns from February to March 1896, and premiered on 2 June 1896 in Paris.

History 

The sonata was composed in Egypt from 17 February to 15 March 1896. It was dedicated to Léon-Alexandre Carembat, who won first prize for violin at the Conservatoire de Paris in 1883 and played for the Orchestre de l'Opéra, and his wife Marie-Louise Adolphi, who won first prize for piano at the Conservatoire in 1883. The couple had given several concerts with Saint-Saëns' works.

The first performance before the official premiere was given by Eugène Ysaÿe and Raoul Pugno on 18 May 1896. The premiere itself, as part of Saint-Saëns' 50th anniversary concert on 2 June 1896 at Salle Pleyel, was given by Pablo de Sarasate and Saint-Saëns for the benefit of the Association des artistes musiciens.

Structure 

The sonata consists of four movements. A performance takes approximately 21 minutes.

Compared to the first violin sonata, which is a brilliant concert piece, the second differs in character. Saint-Saëns himself called it a "very serious chamber work" that "will only be understood after the eighth performance". The sonata signalled a stylistic change in Saint-Saëns' music, with a lighter, clearer sound for the piano, characteristic of his music from then onwards.

Legacy 
As with the first violin sonata, the second sonata was quickly picked up by a number of leading violinists soon after publication.

References

External links 
 

Chamber music by Camille Saint-Saëns
Saint-Saëns
1896 compositions
Compositions in E-flat major
Music with dedications