Samantha912/NLP_A2_WTH huggingface dataset:
{{DISPLAYTITLE:D1–D2 dopamine receptor heteromer}}

The D1–D2 dopamine receptor heteromer is a receptor heteromer consisting of D1 and D2 protomers.

Structure 
D1 and D2 receptors interact primarily through discrete amino acids in the cytoplasmic regions of each receptor, with no involvement of transmembrane parts. The intracellular loop 3 of the D2 receptor contains two adjacent arginine residues, while the carboxyl tail of the D1 receptor possesses two adjacent glutamic acid residues. The two receptors can form a heteromer complex via a salt bridge between the guanidine moiety and the carboxylic group.

Signal transduction 
The signalling of the D1–D2 receptor heteromer is distinct from that of the parent receptor monomers. It comprises Gq/11 coupling, phospholipase C activation, intracellular calcium release from inositol trisphosphate receptor-sensitive stores, CaMKII activation and BDNF production. In comparison, signalling of the homologous D5–D2 receptor heteromer involves the influx of extracellular calcium.

Physiology 
The D1–D2 receptor is upregulated in individuals with major depression, and especially the ratio D1–D2 to D1 receptor is markedly shifted towards the heteromer. Counteracting this upregulation decreases depressive symptoms. Disruption of the heteromer can be achieved either directly by ligands interacting with the cytoplasmic interface, less directly by ligands that target the extracellular binding site, or indirectly as a downstream effect of classical antidepressant treatment. One study found negative results regarding a shift from Gs/a coupling to Gq/11 signaling; so such dynamics could be mediated by cAMP-dependent cascades rather from phospholipase C regulation.

Chronic THC increased the number of D1-D2 heteromer-expressing neurons, and the number of heteromers within individual neurons in adult monkey striatum.

Ligands 
 SKF-83,959

References

Further reading 

 
 
 
 
 
 
 
 
 
 
 
 
 

G protein-coupled receptors
Receptor heteromers
The Jane Donalson Harrell House, located near the Chattahoochee River on County Route 1975 about  south of U.S. 84 in Jakin, Georgia, was built around 1855.  It was listed on the National Register of Historic Places in 1982.

It is a two-story Plantation Plain-style house with Greek Revival features.

References

Plantation Plain architecture
National Register of Historic Places in Early County, Georgia
Houses completed in 1855
Dangerous Flights is a documentary-style reality television show that airs on the Discovery Channel. The show follows the pilots of C.B. Aviation as they ferry light aircraft to their new owners across distances the aircraft weren't designed to fly and often over routes that are generally considered to be dangerous by the aviation community.

Cast

Cory Bengtzen (season one-)
Marcio Lucchese (season one-)
Brad White (season one-)
Pete Zaccagnino (season one-)
Randy McGehee (season one-)
Dave "Super Dave" Mathieson (season one-)
Kerry McCauley (season one-)
Stu Sprung (season one- )
Yasmina Platt (season one-)
Bob Raskey (season one- )
Alex Pichler (season two)
Claire McCauley (season two)

Episodes

Season 1 (2012)

Season 2 (2014)

Incidents

On 24 February 2013, cameraman/director John Driftmier and conservationist Dr. Anthony King were killed in a plane crash in Kenya. Driftmier was shooting footage for Dangerous Flights when the plane, an Aeroprakt A-22L ultralight (registration 5Y-LWF) crashed into the east face of Mount Kenya. Although only a preliminary report has been published thus far, it is believed that a large downdraft forced the ultralight into an unrecoverable descent into the mountain. Driftmier and King were the only occupants.

Broadcast Airings
Repeats of the series are currently airing on the digital broadcast network Quest.

See also

Flying Wild Alaska
Ice Pilots NWT
Alaska Wing Men
Bush Pilots (TV series)
Mayday (TV Series)

References

External links
Dangerous Flights on Discovery Channel
Dangerous Flights on Smithsonian Channel

Dangerous Flights Canada

Discovery Channel (Canada) original programming
Documentary television series about aviation
2010s Canadian reality television series
2012 Canadian television series debuts
2014 Canadian television series endings
The Men's 10 kilometre sprint biathlon competition at the 2006 Winter Olympics in Turin, Italy was held on 14 February, at Cesana San Sicario. Competitors raced over three loops of the 3.3 kilometre skiing course, shooting ten times, five prone and five standing. Each miss required a competitor to ski a 150-metre penalty loop.

Ole Einar Bjørndalen of Norway was the defending World and Olympic champion, but Germany's Michael Greis led the World Cup standings before the Torino Games, with three more Germans in the top six.

Results 

Two Austrian athletes were disqualified after the IOC determined they had violated the Anti-Doping rules; Wolfgang Rottmann had originally placed 27th, while Wolfgang Perner had placed 4th.

The race was held at 13:30.

References

Men's biathlon at the 2006 Winter Olympics
The 2020–21 season was the eleventh in the history of Melbourne City Football Club. The club competed in the A-League for the eleventh time. The club was scheduled to play in the 2021 AFC Champions League qualifying play-offs in June 2021, but withdrew from the competition on 4 June 2021.

Review

Background

On 26 June 2019, Melbourne City appointed Frenchman Erick Mombaerts as new head coach leading the club in being runners-up in the 2019–20 A-League regular season, 2020 A-League Grand Final and 2019 FFA Cup.

Pre-season
The 2020 FFA Cup was cancelled on 3 July 2020.

Nathaniel Atkinson had departed the club for Perth Glory on 1 September 2020. Two days later, the club appointed former assistant coach Patrick Kisnorbo to the head manager position prior to the start of the season on 3 September, after previous coach Erick Mombaerts left the club to return to his native country France. Lachlan Wales was released following the end of his contract, while Aiden O'Neill joined for City's first signing of the season on 8 September.

City signed three youthful players, Taras Gomulka, Marco Tilio and Matt Sutton along with the departure of Gianluca Iannucci on 21 September. Nathaniel Atkinson would then only after 23 days after departing City, had returned within Joshua Brillante leaving two days later. The next day had Andrew Nabbout join City after his short stint with Perth Glory.

Joe Gauci left the club without a single appearance for City and joined Adelaide United on 7 October. The following day, Ramy Najjarine was loaned to Newcastle Jets and Moudi Najjar loaned to Macarthur FC. A week later, Ben Garuccio made a return signing on 16 October.

On 16 November, City played their first friendly of the season, against rivals Melbourne Victory in a game with three 45-minute halves at Marvel Stadium which resulted in a 3–3 draw with a goal by Curtis Good and two from Jamie Maclaren. City returned to the City Football Academy for their second friendly of the season against Western United on 28 November, with a 2–1 win via goals by Andrew Nabbout and Jamie Maclaren.

Players

Transfers

Transfers in

Transfers out

From youth squad

Contract extensions

Pre-season and friendlies

Competitions

Overview

A-League

League table

Results summary

Results by round

Matches
The league fixtures were announced on 24 November 2020.

Finals series

AFC Champions League

Qualifying play-offs

Statistics

Appearances and goals
Players with no appearances not included in the list.

Goalscorers

Disciplinary record

Clean sheets

Awards

Melbourne City Player of the Month
The winner of the award was chosen via a poll on Twitter.

References

Melbourne City FC seasons
2020–21 A-League season by team
The 1976 SCCA/USAC Formula 5000 Championship  was the tenth running of the Sports Car Club of America's premier open wheel racing series and the third to be co-sanctioned by the Sports Car Club of America (SCCA) and the United States Auto Club (USAC).

The championship was won by Brian Redman driving a Lola T332 Chevrolet. It was Redman's third consecutive SCCA/USAC Formula 5000 Championship title win. For the first time in three years, a vehicle other than a Lola won a race, with March and Shadow winning one race each. 1976 also marked the first race win by a non-Chevrolet powered car since the 1971 season, with a Dodge-powered Shadow winning at Road America.

1976 was to be the final year of the SCCA/USAC Formula 5000 Championship as the SCCA replaced it with a revived Can Am Series for 1977. The rules for the new series were to allow the Formula 5000 cars to compete with fully enveloping bodywork.

Race results

The championship was contested over a seven race series.

Points system
Championship points were awarded on a 36-24-16-12-8-5-4-3-2-1 basis for the first ten positions in each race.

Final points standings

References

SCCA Continental Championship
Formula 5000
SCCA USAC Formula 5000 Championship
Michael Kofi Bansah is a Ghanaian security expert and a former Director General of the Ghana Prisons Service.

Director General of Ghana Prisons Service 
In March 2010, the then President of Ghana, John Atta Mills, upon the advice of the Prisons Service Council, appointed her as Acting Director General of the Ghana Prisons Service. He retired in March 2013 and was replaced by Matilda Baffour Awuah.

References 

Ghanaian Director Generals of Prisons
Krisztina Triscsuk (; ; born 17 July 1985) is a retired Russian-Hungarian handballer for Alba Fehérvár KC.

Club
On 14 May 2011, in her sixth season by Fehérvár KC, she surpassed Beatrix Balogh's all-time league scoring record, who hit the back of the net 643 times while playing for the Székesfehérvár-based club. Triscsuk entered the court against Veszprém with only one goal short to the previous record and managed thirteen goals, thus becoming the new league topscorer of Fehérvár.

International
As a youngster, Triscsuk played alongside Emiliya Turey, Lyudmila Postnova and Yekaterina Andryushina in the Russian youth national teams, however, she never made a full international appearance. Since 2004 Triscsuk lives in Hungary and in October 2012 she obtained the Hungarian citizenship. On 10 December 2012 she was called up to the Hungarian squad for the 2012 European Women's Handball Championship as a replacement for Melinda Vincze. Triscsuk made her debut a day later against Romania in a 25–19 victory, with that Hungary secured its place in the semi-finals of the European Championship.

Personal life 
Her husband was Evgeny Lushnikov, former handball player of Veszprém.

Achievements
European Championship:
Bronze Medalist: 2012
 Magyar Kupa:
Silver Medallist: 2006
Bronze Medallist: 2011
EHF Cup
Winner: 2016

Individual awards
Nemzeti Bajnokság I Topscorer: 2010/11, 2016/17

References

External links
Career statistics at Worldhandball

1985 births
Living people
People from Boksitogorsk
Russian female handball players
Hungarian female handball players
Russian expatriates in Hungary
Expatriate handball players
Naturalized citizens of Hungary
Fehérvár KC players
Hungarian people of Russian descent
Sportspeople from Leningrad Oblast
Hotel Christiania Teater – is a historic Oslo city hotel and landmark built in 1918, known primarily for the notability of its theater inside the hotel and recently its unique hotel design by Annemone Wille Waage. The 102-unit hotel is located in Stortingsgata 16, next to Spikersuppa and the main pedestrian street Karl Johans gate with the Royal Palace on one side and the parliament on the other side, around the corner of the building is the Oslo City Hall and just in front of the building the National Theatre. The building has been on the National Register of Historic Places since 2015.

Building
The building was raised 1918 in a post modern Nordic Renaissance style, drawn by the architect , in a joint venture with the Danish architect Hack Kampmann, Hack was also known for Marselisborg Castle, and Ny Carlsberg Glyptotek and museum in Copenhagen.

References

External links

www.restaurantteatro.no
nordichotels.com/
christianiateater.com

1918 establishments in Norway
Hotels established in 1918
Hotel buildings completed in 1918
Hotels in Oslo
Hospitality companies of Norway
Nordic Hotels & Resorts
Ixalerpeton (meaning "leaping reptile") is a genus of lagerpetid avemetatarsalian containing one species, I. polesinensis. It lived in the Late Triassic of Brazil alongside the sauropodomorph dinosaur Buriolestes.

Discovery and naming  
The holotype specimen of Ixalerpeton, numbered ULBRA-PVT059, consists of parts from the skull, vertebral column, and all four limbs. The specimen comes from the Carnian Santa Maria Formation of Brazil, and it was found alongside two individuals of Buriolestes as well as a set of femora belonging to second individual of Ixalerpeton. The genus name of Ixalerpeton combines the Greek words ixalos ("leaping") and erpeton ("reptile"), and the species name polesinensis references the town of São João do Polêsine, where the dig site is located.

Description 

Ixalerpeton was similar to other lagerpetids (namely Dromomeron and Lagerpeton) in having long hindlimbs with well-developed muscle attachments on the femur; in particular, its fourth trochanter was quite large and formed a crest (which is unlike Dromomeron). However, the last few dorsal vertebrae of Ixalerpeton do not have the forward-inclining neural spines of Lagerpeton (which were associated with the latter's hopping, or saltatory, lifestyle). In addition to the enlarged fourth trochanter, a suite of other traits differentiate Ixalerpeton from all previously-described lagerpetids; there is an antitrochanter on the ilium; the end of the shaft of the ischium is tall; there is no ambiens process on the pubis; the medial condyle on the femur is relatively flat at the front end but sharply angled at the back end; and the back face of the top end of the tibia has a deep groove.

The head and forelimbs found with Ixalerpeton are the first of these elements that have been found among lagerpetids. Unlike dinosauriforms, the posttemporal fenestra at the back of the skull is large and unreduced; there is an extra bone, the postfrontal, bordering the eye socket; there is no supratemporal fossa, which is an indentation found on the frontal bone in dinosauriforms; and the glenoid cavity on the scapula, where the scapula-humerus joint is located, faces slightly sideways instead of backwards. On the other hand, there is an anterior tympanic recess on the braincase, and the deltopectoral crest on the humerus is long, both of which are common among basal dinosauromorphs.

Classification 
A 2016 phylogenetic analysis found that Ixalerpeton was the closest relative of Dromomeron. The phylogenetic tree recovered is partially reproduced below.

Paleoecology 
Similar to the Ischigualasto and Chinle Formations, the Santa Maria Formation preserves both Ixalerpeton (a non-dinosaur avemetatarsalian) and Buriolestes (a dinosaur). This indicates that dinosaurs did not rapidly replace related groups once they had evolved.

References 

Lagerpetidae
Late Triassic archosaurs
Carnian genera
Late Triassic reptiles of South America
Triassic Brazil
Fossils of Brazil
Santa Maria Formation
Fossil taxa described in 2016
Taxa named by Alexander Kellner
Vilém Prusinovský z Víckova (in German: William Prusinowsky von Wiczkov) (1534 – June 16, 1572)  was a bishop of Olomouc in 1565–1572. He started his office in the times of Catholic-Protestant controversy and followed the policy of the Council of Trent. He forced the Utraquists to accept his authority. He invited Jesuits to Olomouc and a year after his death, in 1573, his plan of promotion of the Olomouc school to Jesuit Academy was realized and the second oldest university in the Czech lands was established. It is possible he was poisoned by Jan Philopon Dambrovský.

References

External links 

1534 births
1572 deaths
Roman Catholic bishops of Olomouc
16th-century Roman Catholic bishops in the Holy Roman Empire
Victims of serial killers
Mary Anne Eberts   (born January 18, 1947) is a Canadian constitutional lawyer and a former University of Toronto Faculty of Law faculty member. She is a founding member of the Women's Legal Education and Action Fund (LEAF)

Early life and education
Eberts was born in St. Thomas, Ontario. Eberts was educated at University of Western Ontario and Harvard Law School.

Career
Eberts taught law at the University of Toronto (U of T) for six years before joining a Bay Street law firm where she became a partner. She eventually opened her own law practice in 1980, from where she appeared as counsel in the Supreme Court of Canada, Courts of Appeal, and Superior Courts in Ontario. She was influential in the creation of the Canadian Charter of Rights and Freedoms Section 15. She published "Equality Rights and the Canadian Charter of Rights and Freedoms" in 1985. Eberts eventually returned to U of T as an adjunct professor in 1987 to teach constitutional law.

In 1991, Eberts became a litigation counsel to the Native Women's Association of Canada (NWAC). Eberts represented Beth Symes, another founding LEAF member, in Symes v. Canada, [1993] 4 S.C.R. 695. Whereas all legal cases have adversaries by definition, legal scholars have argued that the language of opposition in the Symes case is revealing -- that, although “these men spoke in the rhetoric of institutional constraints, class, and fairness”, their language “still reeks of strategy and self-interest.” 

In 1993, Eberts received an honorary degree of Doctor of Laws, honoris causa, from Concordia University. She was subsequently elected a bencher of the Law Society of Ontario from 1995 until 1999. In 1996, she was a recipient of the Governor General's Award in Commemoration of the Persons Case. She was also a founding member of the Women's Legal Education and Action Fund (LEAF). In 2001, Eberts represented survivors of the Chinese head tax in Canada seeking compensation.

In 2004, she was appointed the Gordon F. Henderson Chair in Human Rights at the University of Ottawa and later became the Ariel Sallows Chair in Human Rights at the University of Saskatchewan College of Law from 2011 until 2012. After her endowed chair term ended, Eberts joined Hensel Barristers as counsel. Two years later, she joined the faculty at Osgoode Hall Law School as a McMurty Fellow. In 2017, Eberts was elected an Officer of the Order of Canada.

References 

Living people
People from St. Thomas, Ontario
Officers of the Order of Canada
Canadian lawyers
Canadian women lawyers
Lawyers in Ontario
Academic staff of the University of Toronto Faculty of Law
University of Western Ontario alumni
Harvard Law School alumni
1947 births
Governor General's Award in Commemoration of the Persons Case winners
Cristina Lago (born January 10, 1982), is a Brazilian cinema and television actress. She played the lead role in five movies.

Filmography

Film

Television

Teatro

References

External links 
 

1982 births
Living people
Brazilian actresses
Brazilian stage actresses
People from Foz do Iguaçu
The 113th United States Colored Infantry (formerly the 6th Arkansas Colored Infantry Regiment) was an infantry regiment that served in the Union Army during the American Civil War. The regiment was composed of African American enlisted men commanded by white officers and was authorized by the Bureau of Colored Troops which was created by the United States War Department on May 22, 1863.

Organization
The regiment was organized at Little Rock, Arkansas, June 25, 1864, from the 6th Arkansas Colored Infantry and assigned to the VII Corps (Union Army).  The unit was later re-designated as the 113th United States Colored Infantry.

Service
The regiment was attached to 1st Division, 7th Corps, Dept. of Arkansas, to January, 1865. The regiment was attached to Colored Brigade, 7th Corps, until February, 1865.

General Orders No. 14, Department of Arkansas, dated February 1, 1865, from Little Rock, included the 113th United States Colored Infantry is reported as belonging to the 2nd Brigade of the 1st Division of the 7th Army Corps.

The regiment was attached to 2nd Brigade, 1st Division, 7th Corps, until April 1865. The regiment was assigned to post and garrison duty at Little Rock, Ark., for its entire term of service.

Consolidated 
The regiment was consolidated with the 11th Regiment United States Colored Infantry (Old) and the 112th U.S. Colored Infantry on April 1, 1865.  The 113th United States Colored Infantry were mustered out a year later, on April 9, 1866.

See also

 List of Arkansas Civil War Union units
List of United States Colored Troops Civil War Units
United States Colored Troops
 Arkansas in the American Civil War

Notes

References
The War of the Rebellion: A Compilation of the Official Records of the Union And Confederate Armies. Series 1, Volume 48, In Two Parts. Part 1, Reports, Correspondence, etc., Book, 1896.
Dyer, Frederick H. (1959). A Compendium of the War of the Rebellion. Sagamore Press, Inc. Thomas Yoseloff, Publisher. New York. LCCN 59-12963

External links
 The Civil War Archive
 Encyclopedia of Arkansas History
 Edward G. Gerdes Civil War Home Page
 The War of the Rebellion: a Compilation of the Official Records of the Union and Confederate Armies
 The Arkansas History Commission, State Archives, Civil War in Arkansas
 

United States Colored Troops Civil War units and formations
Units and formations of the Union Army from Arkansas
1865 disestablishments in Arkansas
Military units and formations disestablished in 1865
Military units and formations established in 1864
1864 establishments in Arkansas
Military units and formations disestablished in 1866
Debendranath Champia (born 24 February 1942), sometimes spelled as Devendra Nath Champia, is an Indian politician and a former member of the Bihar constituency assembly. He represented the Majhgaon (Vidhan Sabha constituency) of Jharkhand, and he is a member of the Indian National Congress (INC) political party.

References 

1942 births
Living people
Jharkhand politicians
Indian National Congress politicians from Bihar
Kominato may refer to:
Kominato, Aomori, a former municipality in Hiranai, Aomori Prefecture, Japan
Kominato, Chiba, a former municipality in Kamogawa, Chiba Prefecture, Japan
Kominato Line, a private railway line in Chiba Prefecture, Japan
Siaogang District, known as Kominato during Japanese rule of Taiwan, in Kaohsiung, Taiwan
Andrei Mikhailovich Bochkov (; born 13 January 1982) is a former Russian footballer.

External links
  Player page on the official FC Shinnik Yaroslavl website
 

1982 births
Living people
Russian men's footballers
Men's association football midfielders
FC Olimpia Volgograd players
FC Elista players
FC Rostov players
FC Shinnik Yaroslavl players
Russian Premier League players
FC Luch Vladivostok players
FC Ural Yekaterinburg players
Footballers from Volgograd
FC Tosno players
FC Sakhalin Yuzhno-Sakhalinsk players
FC Volgar Astrakhan players
FC Neftekhimik Nizhnekamsk players