Chimera, Chimaera, or Chimaira (Greek for "she-goat") originally referred to:
 Chimera (mythology), a fire-breathing monster of Ancient Lycia said to combine parts from multiple animals
 Mount Chimaera, a fire-spewing region of Lycia or Cilicia typically considered the inspiration for the myth

Chimera, chimera, chimère, Chimaira, etc. may also refer to:

Biology
 Chimaera, various cartilaginous fishes of the order Chimaeriformes
 Chimaera (genus), the eponymous genus of the order Chimaeriformes
 Chimera (EST), a single cDNA sequence originating from two transcripts
 Chimera (genetics), a single organism with cells from two different zygotes
 Chimera (virus), with genetic material from other organisms
 Chimeric protein or fusion protein
 Chimera (paleontology), a fossil made with parts from different animals
 Chimera Project, a Soviet biological weapons program

Media

Fictional entities
 Chimera (Fullmetal Alchemist), characters
 Chimera (Marvel Comics), a character
 Chimera (Dungeons & Dragons), a magical beast
 Chimera Anima, a name grouping of animals in the anime Tokyo Mew Mew
 The Chimera, an alien race in Resistance

Films
 Chimera (1968 film), Italian musicarello
 Chimera (2001 film), Italian romance 
 Chimère (film), France, 1989
 Chimères (film), 2013
 Chimera Strain, a 2018 Indian-American film

Gaming
 Chimera (video game), a 1985 adventure
 Chimera (larp convention), Auckland, New Zealand
 Chimera Entertainment, a game developer, Munich, Germany

Literature

 The Chimeras, 1854 sonnets by Gérard de Nerval
 Chimaira, a 2001 novel by Valerio Massimo Manfredi
 Chimera (Barth novel) (1972)
 Chimera (CrossGen), a 2003 comic book series
 Chimaera (novel), by Ian Irvine, 2004
 Chimera (novel series), by Baku Yumemakura, Japan
 Chimera (short story), by Lee Youngdo
 Chimera (2015), novel in Mira Grant's Parasitology trilogy

Music

Groups or artists
 Chimaira, an American heavy metal band from Cleveland, Ohio
 Chimera (Irish band), a musical group
 Chimera (Russian band), an underground musical band
 Mike Dred or Chimera (born 1967), techno musician

Albums
 Chimaira (album), 2005
 Chimera (Andromeda album) (2006)
 Chimera (Aria album) (2001)
 Chimera (Delerium album), 2003, by Delerium
 Chimera (EP), a 2014 EP by Marié Digby
 Chimera (Erik Friedlander album) (1995)
 Chimera (Mayhem album) (2004)
 Chimeras (album), 2003, by John Zorn
 Chimera, by The Cost, 2002
 Chimera, by Duncan Mackay, 1974
 Chimera, by Bill Nelson, 1983
 鵺-chimera-, a 2016 EP by Girugamesh

Songs
 "Chimeres I, II and III", 2007 compositions by Fred Momotenko
 "Chimera", by Duncan Sheik, Daylight (Duncan Sheik album)
 "Chimaera", by Bad Religion from Generator,1992
 "Chimera", by the Tea Party from Triptych, 1999
 "Chimeras", by Tim Hecker from Harmony in Ultraviolet
 "Chimera", by Bonham from Mad Hatter
 "The Chimera", by the Smashing Pumpkins from Oceania, 2012
 "Chimera", by Polyphia from album Remember That You Will Die, 2022

Television
 Chimera (British TV series), 1991
 "Chimera" (NCIS), an episode
 "Chimera" Star Trek: Deep Space Nine), 1999
 "Chimera" (Stargate SG-1), an episode
 "Chimera" (The X-Files), an episode
 Chimera (South Korean TV series), 2021

People
 Jason Chimera (born 1979), NHL ice hockey player
 Chimaera, a ring name of Ricardo Rodriguez (wrestler) (b. 1986), wrestler

Computing
 Chimera (software library)
 Camino (web browser) or Chimera
 UCSF Chimera, software to visualize molecules

Other uses
 Chimaera (town), ancient Himarë, Albania
 Chimaera Mountains, an ancient Ceraunian Range, Albania
 Chimera (spacecraft) proposal
 Chimera (architecture), or grotesque
 TVR Chimaera, a car
 Chimera (roller coaster), La Feria Chapultepec Mágico, Mexico City

See also
 Quimera International Festival, Metepec, Toluca, Mexico