Samantha912/NLP_A2_WTH huggingface dataset:
Neutral cholesterol ester hydrolase 1 (NCEH) also known as arylacetamide deacetylase-like 1 (AADACL1) or KIAA1363 is an enzyme that in humans is encoded by the NCEH1 gene.

NCEH is an enzyme located in the endoplasmic reticulum.  NCEH hydrolyzes 2-acetyl monoalkylglycerol ether, as part of an enzymatic pathway regulating the levels of platelet activating factor and lysophospholipids that may be involved in cancer development.

Function 

The enzymatic reaction catalyzed by NCEH is:

 2-acetyl monoalkylglycerol ether → monoalkylglycerol ether

Monoalkylglycerol ethers (MAGEs) can then be converted to lysophospholipids alkyl-lysophosphatidic acid (alkyl-LPA) and alkyl-lysophosphatidylcholine (alkyl-LPC).

Controversial studies by one group also implicate the protein in the hydrolysis of cholesterol esters.  However, loss of the protein in mice selectively reduces 2-acetyl monoalkylglycerol ether activity throughout the body.

Clinical significance 

Evidence suggests a role for NCEH in cancer.  Cancer cell lines contain unusually high levels of the protein.  Reduction of the amount of NCEH1 in cancer cells reduces tumor migration and growth in mice and addition of alkyl-LPA restores these processes.

NCEH can break down organophosphates like the pesticide metabolite chlorpyrifos oxon.  Conversely, enzymatic activity can be inhibited by organophosphates.

Structure 

NCEH is a serine hydrolase that contains an N-terminal transmembrane domain, a central catalytic domain and a lipid-binding domain at its C-terminus.  The protein exists in three isoforms that result from differences in mRNA splicing.  Transcripts encode a protein for isoform a of 448, b of 440 and c of 275 amino acids long.

See also 
 Autotaxin
 phosphatidic acid
 Lysophospholipid receptor
 LPA signaling

References

Further reading 
 
 
 
 
 
 

EC 3.1.1
1981National Professional Road Race Championship
William Nickson (born 30 January 1953) is a British former cyclist. He won the 1976 Milk Race whilst riding for the Great Britain "A" team. He competed in the individual road race and team time trial events at the 1976 Summer Olympics. He also rode in the 1977 Tour de France.

References

External links
 

1953 births
Living people
British male cyclists
Olympic cyclists for Great Britain
Cyclists at the 1976 Summer Olympics
Sportspeople from Liverpool
Knowledge collection from volunteer vontributors (KCVC) is a subfield of knowledge acquisition within artificial intelligence which attempts to drive down the cost of acquiring the knowledge required to support automated reasoning by having the public enter knowledge in computer processable form over the internet. KCVC might be regarded as similar in spirit to Wikipedia, although the intended audience, artificial Intelligence systems, differs.

History 
The 2005 AAAI Spring Symposium on Knowledge Collection from Volunteer Contributors (KCVC05) may have been the first research meeting on this topic.

The first large-scale KCVC project was probably the Open Mind Common Sense (OMCS) project, initiated by Push Singh and Marvin Minsky at the MIT Media Lab. In this project, volunteers entered words or simple sentences in English in response to prompts or images. Although the resulting knowledge is not formally represented, it is provided to researchers with parses and other meta-information intended to increase its utility. Later, this group released ConceptNet, which embedded the knowledge contained in the OpenMind Common Sense database as a semantic network.

In late 2005, Cycorp released a KCVC system called FACTory that attempts to acquire knowledge in a form directly usable for automated reasoning. It automatically generates questions in English from an underlying predicate calculus representation of candidate assertions produced by automated reading of web pages, by reviewing information previously entered directly in logical form, and by analogy and abduction.

References

External links
Open Mind Project
Open Mind Common Sense
ISI's Learner
Cycorp's FACTory

Knowledge engineering
Opposition Alliance may refer to:

Nation Alliance (Turkey), an electoral alliance of opposition parties in Turkey
Opposition (Western Australia), the National-Liberal Alliance formed in Western Australia in 2021
Opposition Alliance of Kosovo
South Sudan Opposition Alliance, a coalition of political parties and armed groups in South Sudan

See also
Opposition (politics)
Robert of Burgundy (c. 1300 – 3 or 4 September 1317) was the only son of Otto IV, Count of Burgundy and Mahaut, Countess of Artois.

Life
Robert of Burgundy was disinherited before being born. Indeed, by a treaty signed on 2 March 1295, Otto IV had offered his eldest daughter Joan in marriage to Philip, the second son of Philip IV of France, and granted her with a dowry including all his Burgundian possessions.

On 8 May 1306 Robert was betrothed to Eleanor, the youngest daughter of Edward I of England. On 4 October of the same year, Pope Clement V granted a dispensation allowing the union of Robert and Eleanor. Unfortunately, Eleanor died prematurely in 1311, putting abruptly an end to the marriage project.

Robert of Burgundy died on 3 or 4 September 1317 at the Hôtel d'Artois in Paris and was buried in the church of the Cordeliers, before his tomb was transferred to the royal necropolis of the Basilica of Saint-Denis during the 19th century.

Ancestry

Notes

References
 Funck-Brentano, Frantz. (1888) Philippe le Bel et la noblesse franc-comtoise. Paris: Bibliothèque de l'École des chartes.
 Hellot, Amédée. (1884) Chronique Parisienne Anonyme de 1316 à 1339. Nogent-le-Rotrou: Daupeley-Gouverneur.
 Weir, Alison. (2011) Britain's Royal Families : The Complete Genealogy. London: Random House. .

1300s births
1317 deaths
Chalon-Arlay

Year of birth uncertain
Max Finkelstein (March 5, 1884–May 3, 1940) was a captain in the New York City Police Department.

Police career
As president of Shomrim, a fraternal order of Jewish New York City police officers, he became famous in 1938 when Fiorello H. La Guardia picked him to lead a special squad whose job was to safeguard visiting officials from Nazi Germany and guard the German consulate. A popular belief was that La Guardia's decision to appoint Finkelstein and the other Jewish officers was inspired by actions taken by Theodore Roosevelt, when he was New York City Police Commissioner, who assigned 40 Jewish police officers to protect, and make look "ridiculous", Hermann Ahlwardt, when he gave an anti-semitic speech in New York. While a popular story published by the Times during a later period of anti-Nazism, this story is not supported by news articles of the time and in fact the names of officers printed during Ahlwardt's 1895 visit are Anglo or Irish names, such as Cartright and O'Brien, not generally used by Jews.

The Nazis reacted to Finkelstein's appointment with anger. A photo of Finkelstein appeared on the front page of the Nazi newspaper Der Angriff, which decried the choice of Finkelstein and the other Jewish officers as a "provocation" and wondered how Americans would react if their diplomats in Germany were placed under the protection of black policemen.

Death
In 1940, after 29 "spotless" years with the New York City police, Finkelstein requested retirement. However, after being told "that he would be required to face charges of accepting irregular bail bonds", he committed suicide.

The New York Times reported that 10,000 people "thronged the neighborhood" during Finkelstein's funeral. Finkelstein was interred in Montefiore Cemetery in Queens.

Depicted on stage and screen
Finkelstein's experience guarding Nazi diplomats in New York served as the basis for a character in the 1939 Broadway play Margin for Error by Clare Boothe Luce.  The play was made into a film of the same name in 1943. The film was directed by Otto Preminger and the Finkelstein character was played by Milton Berle.

References

External links

1884 births
1940 deaths
New York City Police Department officers
Jewish American police officers
Suicides in New York City
Heinrich Kodré (8 August 1899 - 22 May 1977) was an Austrian military officer, Knight's Cross recipients and resistance fighter. As chief of the general staff in military district XVII, Vienna, he set off the Operation Valkyrie on 20 July 1944, massively exceeding his powers, which was strictly reserved for the respective commander in the military district, but by no means a right of the chiefs of staff. Together with Captain Carl Szokoll and Colonel Rudolf von Marogna-Redwitz, he then successfully carried out “Walküre”, which otherwise only succeeded in Paris.

Early life
Kodré was born in 1899 to Richard Kodré and his French wife Henriette Crochet. His father came from Trieste and was a department head in the Emperor Ferdinand Northern Railway. His uncle, Franz Kodré, was the director of the Justizanstalt Stein and was shot dead on 6 April 1945 by members of the Wehrmacht and the Waffen SS as part of an end-stage crime because he had allegedly unlawfully released several hundred political prisoners.

Awards and decorations
 Knight's Cross of the Iron Cross on 14 May 1941 as Major and Commander of the II./Infanterie-Regiment 123

References

1899 births
1977 deaths
German Army officers  of World War II
Austrian military personnel of World War II
Austrian resistance members
Austrian expatriates in Germany
Military personnel from Vienna
Members of the 20 July plot
Recipients of the Knight's Cross of the Iron Cross
Ndumu Nji Vincent  born October 16, 1960, is a Cameroonian civil engineer ,who served as Government Delegate to the Bamenda City Council from March 2009 to February 2020 He also served as President of the GCE Board Tender. He is married (Hilda Ndumu Swiri) and father of 4 children. Appointed by Presidential Decree, he has been government delegate since March 2, 2009, when he took over from Tadzong Abel Ndeh who had served for 16 years. Before being in charge of this, he worked for the Ministry Of Public Works and in charge of weighing stations at the Prime minister's office. He at that time was a Technical Advisor(Conseiller Technique).

Widely regarded by many as the man who changed Bamenda, his no tolerance has lifted Bamenda from a city filled with  containers into a city which is reaching modernisation  with great population growth " . Credit is given from his many years as a seasoned civil engineer(from the University of Manchester)

References

Cameroonian engineers
1960 births
Living people
People from Bamenda
Meledella is a monotypic genus of gastropods belonging to the family Zonitidae. The only species is Meledella werneri.

The species inhabits terrestrial environments.

References

Zonitidae
Jacob Alexander Haller Jr. (May 20, 1927 – June 13, 2018) was an American pediatric surgeon who served as the first Robert Garrett Professor of Pediatric Surgery at the Johns Hopkins School of Medicine.

Haller Jr. was born in Pulaski, Virginia, to a family of dentists and physicians originally from York, Pennsylvania. His father, J. Alex Haller Sr., raised him with the help of two aunts, after his mother, Julia Allison, died. Haller Jr. contracted scarlet fever as a child, which led him to study medicine. He played basketball and football at Pulaski High School, graduating in 1944. Haller considered attending the University of Virginia in his home state, but was accepted at Vanderbilt University, where he had applied at his high school principal's suggestion. There, Haller met his future wife, Emily Simms, and played for the Vanderbilt Commodores men's basketball team until his senior year of college. Haller planned to enroll at the Vanderbilt University School of Medicine, but applied to the Johns Hopkins School of Medicine, having heard from professors that Hopkins specialized in surgery, his field of choice. After completing his medical degree at Hopkins in 1951, Haller pursued further study in Europe on the advice of Arnold R. Rich. Haller was trained in pathology under Hans von Meyenburg at the University of Zurich.

Haller was conscripted after his return from Switzerland. Rejected by the United States Navy due to color blindness, he instead joined the Coast Guard in 1953, where he served six months at the Coast Guard Surgical Unit in San Pedro, California. He later transferred to the National Heart Institute, where he served until 1955. After completing his residency at Hopkins, Haller began teaching at the University of Louisville in 1959, and later served as chief of cardiac surgery at the Louisville General Hospital.

Haller returned to Johns Hopkins in 1963 as assistant professor of surgery, and led the newly established pediatric surgery division. He was appointed the first Robert Garrett Professor of Pediatric Surgery in 1967. Over the course of his career, Haller helped develop the Advanced Pediatric Life Support program, and the Maryland Emergency Medical Services system. He is the namesake and co-creator of the Haller index. Haller was a founding member and later president of the American Pediatric Surgical Association. He retired in 1992.

Haller died at home in Glencoe, Maryland, on June 13, 2018, aged 91.

References

External links

1927 births
2018 deaths
American pediatric surgeons
People from Pulaski, Virginia
University of Louisville faculty
Vanderbilt Commodores men's basketball players
Johns Hopkins University faculty
Johns Hopkins School of Medicine alumni
Physicians from Virginia
United States Coast Guard officers
National Institutes of Health people
University of Zurich alumni
20th-century surgeons
American men's basketball players
Medical personnel for the United States Coast Guard
Women's Super-G World Cup 1988/1989

Calendar

Final point standings

In Women's Super-G World Cup 1988/89 all four results count.

References
 fis-ski.com

External links
 

World Cup
FIS Alpine Ski World Cup women's super-G discipline titles
Anusha Mani (born 29 March 1985) is an Indian female playback singer who works actively in the Bollywood film industry.

Early and personal life
Anusha hails from a musically-inclined family, and learnt Carnatic music from Smt Meera Nathan. Having sung in Gujarati plays, she met Amit Trivedi with whom she made a music album, which was never released.

She is married to singer-composer Sangeet Haldipur of Sangeet-Siddharth, the son of Amar Haldipur and brother of Siddharth Haldipur.

Career
Her big break came in 2007, when Shankar Mahadevan of Shankar–Ehsaan–Loy offered her the chance to sing the track Dhoka from Johnny Gaddaar after listening to an album she'd appeared on. She has since then worked in about six albums with the trio to date. She had also sung and written the track Dil Mein Jaagi from the Dev.D, which won Amit Trivedi the National Film Award for Best Music Direction. She also does concerts for musicians. Her Lehrein song which was written by Javaid Akhtar was included in Aisha Movie. The Fearless & fabulous Anusha was a part of the TV show MTV Angles of Rock where she along with Shalmali Kholgade, Jasmine Sandlas & Akasa Singh set out on an epic road trip & inspired women from all across the nation, performing some of their amazing original composition 5 In 2021. Mani featured in a unique film focussed on the plight of stray animals.

Filmography
 Johnny Gaddaar (2007)
 Thoda Pyaar Thoda Magic (2008)
 Dev.D (2009)
 Sikandar (2009)
 Hum Tum Aur Ghost (2010)
 Tere Bin Laden (2010)
 Aisha (2010)
 Game (2011)
 Don 2: The King is Back (2011)
 Chennai Express (2013)
 Shaandaar (2015)
 Ruler (2019)
 The Tails of Boo Boo and Cuddly Poo (2021)

References

External links
 
 Anusha Mani : Filmography and Profile  on Bollywood Hungama

Living people
Bollywood playback singers
Indian women playback singers
1985 births
21st-century Indian singers
21st-century Indian women singers
' Ambodivoananto is a village and commune in the Vatomandry (district) in the Atsinanana Region, Madagascar.

References

Populated places in Atsinanana
Michael Leslie Yorke (25 March 1939 – 19 April 2019) was an Anglican priest in the last decades of the 20th century and the first years of the 21st. He was born on 25 March 1939 and educated at Midhurst Grammar School and Magdalene College, Cambridge. Ordained in 1965 his first post was a curacy at Croydon Parish Church  after which he served as Succentor, Precentor and Chaplain at Chelmsford Cathedral. Following this he was Rector of Hadstock, a Canon Residentiary at Chelmsford Cathedral, Vicar of St Margaret’s with St Nicholas, King’s Lynn and Provost of Portsmouth Cathedral. In 1999 he became Dean of Lichfield, and was Dean Emeritus in retirement.

He died on 19 April 2019 at the age of 80.

Notes

1939 births
2019 deaths
People educated at Midhurst Grammar School
Alumni of Magdalene College, Cambridge
Provosts and Deans of Portsmouth
Deans of Lichfield
Georgi Petrov may refer to:

Georgi Petrov (judoka) (born 1954), former Bulgarian judoka
Georgi Petrov (badminton) (born 1980), Bulgarian badminton player
Georgi Petrov (footballer, born 1974), former Bulgarian  footballer
Georgi Petrov (footballer, born 1991), Bulgarian footballer for Lokomotiv Plovdiv
Georgi Petrov (ice hockey) (born 1988), Kazakh ice hockey player
This is a list of professional wrestling websites. Online websites who focus mostly or exclusively on professional wrestling.

News websites

Historical websites

Sales websites

Comedy websites

See also
 Dirt sheet
 List of professional wrestling magazines
 List of professional wrestling streaming services

References

Professional wrestling
 
websites
Metabolic Technologies, Inc is an American life sciences company that sells dietary supplements and analytical services. Metabolic Technologies is headquartered in Ames, Iowa.

The company has sponsored a number of clinical trials for the nutritional supplement HMB.

References

External links
 Official site

Nutritional supplement companies of the United States
Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.

Function 

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit C, forms a tight dimer with the B subunit (NFYB), a prerequisite for subunit A (NFYA) association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. Additional regulation, preliminarily supported by the EST database, may be represented by alternative splicing in this subunit.

Two microRNAs; miR-30c and miR-30e are located within introns of the nfyc gene.  These microRNAs are actively transcribed in human insulin-producing beta cells in the pancreatic islets that also show high expression of nfyc and CDH1 genes.  The expression of these intronic microRNAs is essential for maintaining the differentiated phenotype of human islet beta cells.  Inhibition of miR-30 family microRNAs induces epithelial-mesenchymal transition of human pancreatic islet cells.

Interactions 

NFYC has been shown to interact with Myc.

References

Further reading

External links 
 

Transcription factors
Childebrand I (678 – 743 or 751) was a Frankish duke (dux), illegitimate son of Pepin of Heristal and Alpaida, and brother of Charles Martel. He was born in Autun, where he later died. He married Emma of Austrasia and was given Burgundy by his father, becoming a duke. He distinguished himself in the expulsion of the Saracens from France alongside his brother when he captured Marseille, one of the largest cities still in Umayyad hands.

He was the patron of the continuator of the Chronicle of Fredegar, as was his son Nibelung I or Nivelon.

Some scholars believe that Childebrand was actually the half-brother of Charles Martel, related through his father. Childebran describes Charles Martel as 'germanus' meaning same mother, different father. Most accounts have Childebran's birth as 670 and the older half-brother of Charles Martel, with his father being named Fulcoald, who was the second son of Childebert, born in 602 to Theuderic II, King of Austrasia. Childebran's mother, Alpais, was the daughter of Childebert's first son, also named Childebran. Peppin and Alpais may have had another son, a younger brother of Charles Martel who was named Childebran as well. Childebran I acknowledged one son, Nivelon I, whose descendants bore the names of Fulcoald, Childebran, and Nivelon. William of Gellone and Raoul I(Robertian) are the only male descendants of Childebran I to become kings. His date of death is also contentious, as some sources place his death at 743 while others claim he lived until 751.

References

Notes 

678 births
751 deaths
8th-century Frankish nobility
Frankish warriors
Pippinids
People from Autun
7th-century Frankish nobility
Golazin Ardestani (Persian: گل آذین اردستانی), better known by her stage name Gola or Golazin (Persian:گل آذین), is an Iranian singer-songwriter, musicologist, vocalist and actress based in London. She plays piano, santur, dammam (Persian percussion) and the flute.

Early life 
Ardestani grew up in Isfahan, Iran. She studied music composition and performance at Tehran's University of Soureh. In 2011, she moved to London to pursue a master's degree in music psychology at Roehampton University.

Career 
When she was 19, Gola joined Iran's first girlband, Orchid, which was only allowed to play before a female audience in Iran because of local laws. She was arrested three times in Iran. Following her tours with Orchid, she honed her own tastes as an artist and garnered a fervent fan base.

The restrictions in place for female singers in Iran, and political unrest, fueled Golazin's decision to move to London in 2011. Her debut single, "Miri", received over 3 million listens on Radio Javan.

In 2018, Gola released the single "The Line", her first track in English. Her single "Booseh" was streamed more than 800,000 times in the month after its release. She released the single “Now You Know” in 2019. She has worked alongside Idan Raichel and Iranian rapper Hossein Tohi. Gola creates music influenced by both Eastern and Western music, with an underlying message of raising awareness of Iran.

Discography

Persian singles
 Miri 
 Khoda Danad 
 Booseh 
 Bi Gonah
 Hess
 Iranian
 Eshghe Ariaei
 Behtarin Abi
 Khodam Boodam Oonja
 Raghse Shirin
 Betars Az Man
 Khodavanda
 Khosh Be Halam

English singles
 The Line
 Now You Know

References

External links
 

Year of birth missing (living people)
Living people
21st-century Iranian women singers
Musicians from Isfahan