Samantha912/NLP_A2_WTH huggingface dataset:
Prenylamine (Segontin) is a calcium channel blocker of the amphetamine chemical class that was used as a vasodilator in the treatment of angina pectoris.

History 
Prenylamine was introduced in the 1960s by German manufacturer Albert-Roussel pharma gmbh, which was acquired by Hoechst AG in 1974 and which in turn became part of Sanofi Aventis in 2005.

It was withdrawn from market worldwide in 1988 because it caused QT interval prolongation and torsades de pointes, greatly increasing the risk of sudden death. The cardiac side effects were not detected during clinical development, only becoming apparent after the drug was in wide use.

Mechanism of action 
Prenylamine has two primary molecular targets in humans: calmodulin and myosin light-chain kinase 2, found in skeletal and cardiac muscle. Pharmacologically, it decreases sympathetic stimulation on cardiac muscle, predominantly through partial depletion of catecholamines via competitive inhibition of reuptake by storage granules, leading to further depletion due to spontaneous leakage as a result of disturbance of equilibrium. This depletion mechanism is similar to that of reserpine because both agents target the same site on the storage granule; however, prenylamine shows a high affinity for cardiac tissue, while reserpine is more selective toward brain tissue. 

Prenylamine slows cardiac metabolism via calcium transport delay by blockade of magnesium-dependent  calcium transport ATPase. It demonstrate beta blocker–like activity that results in reduction of heart rate but shows an opposing effect on tracheal tissue response.

References 

Vasodilators
Substituted amphetamines
Calcium channel blockers
Norepinephrine-dopamine releasing agents
The 2021 Pennzoil 400 presented by Jiffy Lube was a NASCAR Cup Series race held on March 7, 2021 at Las Vegas Motor Speedway in Las Vegas. Contested over 267 laps on the  asphalt intermediate speedway, it was the fourth race of the 2021 NASCAR Cup Series season.

Report

Background

Las Vegas Motor Speedway, located in Clark County, Nevada outside the Las Vegas city limits and about 15 miles northeast of the Las Vegas Strip, is a  complex of multiple tracks for motorsports racing. The complex is owned by Speedway Motorsports, Inc., which is headquartered in Charlotte, North Carolina.

Entry list
 (R) denotes rookie driver.
 (i) denotes driver who are ineligible for series driver points.

Qualifying
Kevin Harvick was awarded the pole for the race as determined by competition-based formula.

Starting Lineup

Race
Kyle Larson won the race for Hendrick Motorsports, driving the #5 HendrickCars.com Chevrolet. It was his first win since he was sacked by Chip Ganassi Racing in 2020 after he said a racial slur. He also won stage two. Brad Keselowski finished second after winning stage one. Kyle Busch finished third after he passed Denny Hamlin, who was followed by Ryan Blaney.

Stage Results

Stage One
Laps: 80

Stage Two
Laps: 80

Final Stage Results

Stage Three
Laps: 107

Race statistics
 Lead changes: 27 among 12 different drivers
 Cautions/Laps: 6 for 30
 Red flags: 0
 Time of race: 2 hours, 52 minutes and 7 seconds
 Average speed:

Media

Television
Fox Sports covered their 21st race at the Las Vegas Motor Speedway. Mike Joy, 2001 race winner Jeff Gordon and Clint Bowyer called the race from the broadcast booth. Jamie Little and Regan Smith handled pit road for the television side. Larry McReynolds provided insight from the Fox Sports studio in Charlotte.

Radio
PRN covered the radio call for the race which was also simulcasted on Sirius XM NASCAR Radio. Doug Rice and Mark Garrow called the race in the booth where the field raced through the tri-oval. Rob Albright called the race from a billboard in turn 2 where the field raced through turns 1 and 2. Pat Patterson called the race from a billboard outside of turn 3 where the field raced through turns 3 and 4. Brad Gillie, Brett McMillan and Wendy Venturini worked pit road for the radio side.

Standings after the race

Drivers' Championship standings

Manufacturers' Championship standings

Note: Only the first 16 positions are included for the driver standings.

References

2021 in sports in Nevada
2021 NASCAR Cup Series
March 2021 sports events in the United States
NASCAR races at Las Vegas Motor Speedway
Séïbou Mama (born 28 December 1995) is a Beninese professional footballer who plays as a midfielder for French club Vannes and the Benin national team.

International career
At the youth level he played in the 2013 African U-20 Championship. He represented the senior national team at the 2019 Africa Cup of Nations, where the team reached the quarter-finals.

Career statistics

International

Scores and results list Benin's goal tally first, score column indicates score after each Mama goal.

References

External links
 
 

1995 births
Living people
People from Parakou
Beninese men's footballers
Men's association football midfielders
Benin men's international footballers
Benin men's under-20 international footballers
2019 Africa Cup of Nations players
USS Kraké players
ASPAC FC players
Les Buffles du Borgou players
SC Toulon players
Vannes OC players
Benin Premier League players
Championnat National players
Championnat National 2 players
Beninese expatriate men's footballers
Beninese expatriate sportspeople in France
Expatriate men's footballers in France
Bartholomäus Metlinger (born in Augsburg – died c. 1491) was a German physician of the Late Middle Ages.

Metlinger graduated in 1470 from the University of Bologna. He was city physician () in Nördlingen from 1476 to 1483, when he took the same position in Augsburg, probably succeeding his late father Peter Metlinger.

His most famous work,  ('Little Book on Children'), was published on 7 December 1473, being retitled in later editions as  ('A Guide on Young Children'). It was the first German-language work on pediatrics. In it, Metlinger deals with the care of infants and small children up to the age of seven. The book describes several childhood diseases and their treatments, besides providing educational advice. It also contains one of the first known written definitions of a pacifier.

See also 
 Eucharius Rösslin
 Felix Würtz
 Swaddling

Bibliography 
 Walter Martin Manzke: Remedia per infantibus: Medicinal child therapy in the 15th and 16th centuries, illustrated by means of selected diseases (dissertation in the Department of Pharmacy at the University of Marburg.). 2008. http://d-nb.info/987944800/34
 John Ruräh: Bartholomaeus Metlinger -1491. in American Journal of Diseases of Children, 35 (3), 1928, pp 492–494.
 Susanne Scheibenreiter: Diseases of the child in the Middle Ages (Unpublished thesis, University of Vienna, Faculty of History). 2008, 93 pages. http://othes.univie.ac.at/1341/1/2008-10-03_5600012.pdf

External links 
 Bartholomäus Metlinger on digitale-sammlungen.de

References 

German pediatricians
15th-century German physicians
15th-century educators
Education writers
German-language writers
Physicians from Augsburg
German medical writers
German male non-fiction writers
15th-century German writers

1490s deaths
Year of birth missing
Year of death uncertain
Identity was a planned massively multiplayer online role-playing game (MMORPG) that was developed and published by Asylum Entertainment, Inc. for Microsoft Windows and macOS. In the game, players would have the freedom to do a variety of activities in an open world setting, including karaoke and paintballing and join a wide set of career options. The game was to allow players to customize and furnish their own homes. During its one month Kickstarter campaign, Identity raised CA$187,859 by 4,218 backers.

The Kickstarter promised a December 2016 release with full access for backers but failed to deliver its promise. In September 2018 the developers announced that the Town Square Module, an Early Access version of the game with limited features, would be available to those who pledged on the game's Kickstarter campaign or paid a set fee two years after the promised Town Square's release. It was released on Steam on November 30, 2018 to a generally negative user response.

References

External links 
 
 Kickstarter page

Cancelled macOS games
Cancelled Windows games
Early access video games
Kickstarter-funded video games
Massively multiplayer online role-playing games
The New Luika Gold Mine is an active mine in the Lupa Gold Field, an area of about  in south west Tanzania, north of Mbeya, that is known for its gold deposits. It is the principal mine of Shanta Gold and saw its first gold pour in August 2012.

In September 2016 Shanta Gold reported that from its underground exploration efforts, the indicated gold deposits of the mine increased by 409% to 205,000 Oz. This is a big discovery for the company as the company expects to deplet the Luika surface mine by 2020.

References

External links
 MINING IN TANZANIA A brief on the Tanzanian Mineral Sector.

Gold mines in Tanzania
Juan Pablo Brzezicki (born 12 April 1982) is a retired Argentine professional tennis player.

Tennis career

In 2007, Brzezicki was the Argentine surprise at the French Open, one of the four tennis Grand Slams, by reaching the third round before losing to his idol Carlos Moyá of Spain. He won his first Challenger singles title in 2007 at Salinas, Ecuador. With Juan Pablo Guzmán, he won his first ATP doubles title at Amersfoort in 2007. He reached a career-high singles ranking of World No. 94 in February 2008.

In February 2012, after his participation in the ATP 250 in Buenos Aires he announced that he retired after eleven years.

Performance timeline

Singles

ATP career finals

Doubles: 1 (1 title)

ATP Challenger and ITF Futures finals

Singles: 23 (7–16)

Doubles: 36 (21–15)

References

External links
 
 

1982 births
Living people
Argentine male tennis players
Argentine people of Polish descent
Tennis players from Buenos Aires
The Hikurangi River is a river of Northland, New Zealand. A winding stretch of river, it can be considered an extension of the Kaikou River, being formed from the confluence of this river and the Moengawahine Stream. The Hikurangi flows south past the Pipiwai settlement for several kilometres before flowing into the Mangakahia River,  west of Whangarei.

See also
List of rivers of New Zealand

References

Rivers of the Northland Region
Rivers of New Zealand
Kaipara Harbour catchment
Ceratostoma foliatum, or leafy hornmouth is a species of medium to large sea snail, a marine gastropod mollusk in the family Muricidae, the rock snails.

Distribution
This species lives in the Eastern Pacific.
Known from California, West coast of North America.

References

Muricidae
Gastropods described in 1791
Taxa named by Johann Friedrich Gmelin
Beata or Beate is a female given name or Portuguese surname that occurs in several cultures and languages, including  Italian, German, Polish, and Swedish, and which is derived from the Latin beatus, meaning "blessed". Variants include Bea, Beade and Beáta. The name may refer to:

 
Beata Asimakopoulou (1932–2009), Greek actress
Beate Bille, (born 1976), Danish actress
Beata Brookes (1931–2015), British politician
Beata Bublewicz (born 1975), Polish politician
Beate Bühler (born 1964), German volleyball player 
Beata Gosiewska (born 1971), Polish politician
Beata Harju (born 1990), Finnish actress and filmmaker
Beate Heister (born 1951), German billionaire
Beata Kaczmarska (born 1970), Polish race walker
Beata Kitsikis (1907–1986), Greek politician
Beate Klarsfeld (born 1939), German Nazi hunter
Beata Kozidrak (born 1960), Polish singer
Beata Losman (born 1938), Swedish archivist
Beata Mikołajczyk (born 1985), Polish sprint canoer
Beata Obertyńska (1898–1980), Polish writer
Beata Papp (born 1985), Finnish figure skater
Beata Pozniak (born 1960), Polish actress
Beata Rosenhane (1638–1674), Swedish writer
Beate Sirota (1923–2012), American performing arts presenter
Beata Sokołowska-Kulesza (born 1974), Polish sprint canoer
Beata Sabina Straas (died 1773), Swedish actress
Beata Szydło (born 1963), Polish politician and prime minister
Beata Tyszkiewicz (born 1938), Polish actress
Beate Uhse-Rotermund (1919–2001), German pilot and entrepreneur
Beate Zschäpe (born 1975), German convicted neo-Nazi terrorist

References

See also
 Beat (male given name)
 Beatus (male given name)

Polish feminine given names
Feminine given names
German feminine given names
Swedish feminine given names
Logan Nelson (born November 11, 1996) is an American composer who has composed scores for films, video games, and modern dance productions. In 2018, he received the SABAM Award for Best Young International Composer by the World Soundtrack Academy. He is known for his work with Kris Bowers, where he composed additional music on the scores to Green Book, Dear White People and For the People.

Life and education 
Nelson was born and raised in Wichita, Kansas. In his early years, he "fell in love with" the viola and studied piano and composition with local professors. Nelson attended the University of Southern California where he majored in Music Composition and minored in Cinematic Arts. At USC, he studied music composition with Ted Hearne and film scoring with Garry Schyman; Nelson worked closely with the Glorya Kaufman School of Dance and a solo violinist to "sample unique and interesting violin textures that [he] later produced into electronic elements" in collaboration with student choreographers, the project concluded with two performances.

Nelson worked on over 30 original short film scores at USC. His score for Pepper was named Best Original Score by the NYC Indie Film Awards.

Career 
In his first summer in Los Angeles, Nelson was offered a prestigious position as an assistant for film composer Hans Zimmer's, Remote Control Productions. Following this, he began working as the composition assistant for Kris Bowers. With Bowers, Nelson assisted on the scores to television projects like Dear White People (TV series) and For the People (2018 TV series). Additionally, Nelson wrote additional music with Bowers on the Sundance Film Festival selection, Monsters and Men, as well as the Tribeca Film Festival selection, Unstoppable. His most recent project with Bowers was Green Book (film).

Logan just finished collaborating with documentary filmmaker Renan Ozturk on a piece with National Geographic and Sony about Mt. Everest. He recently scored the romantic comedy, Straight Up. The film was produced by Valparaiso Pictures and stars actress Katie Findlay.

Nelson also produces music for the synth-pop duo, LightHouse. Their song, Nebula, was described by NEST HQ (Owsla) as "mature, highly-refined synth-pop brilliantly contrasting bright, summery sounds with ghostly, melancholy vocal harmonies and a dark, echoing flair to the production." LightHouse was just featured in FLAUNT Magazine.

Awards and honors 

 Winner, SABAM Award for Best Young International Composer, 2018
 Winner, National YoungArts Foundation, 2015 and 2016

References

External links 

Logan Nelson on Instagram
Logan Nelson on Twitter
Official Website

1996 births
American film score composers
Record producers from Kansas
American television composers
Living people
American male film score composers
Male television composers
Lasius brunneus is a species of ant in the genus Lasius. The species is widely distributed in Europe, from Sweden in the north to Anatolia in the south. In England this species is almost always found nesting in oak trees or rotting wood mainly foraging in trees but has also been found under stones and foraging on the ground. It is thought to be underrecorded but is fairly common especially in the South East.

Workers are easy to identify as they are bicoloured, but they can be confused with Lasius emarginatus. Nuptial flights have been recorded as early as May on warm days from early morning to early afternoon. Queens are smaller than other Lasius species, mainly a uniform dark brown colour with a flattish, slim appearance.

References

brunneus
Hymenoptera of Europe
Insects described in 1798
St Leonard's Place is a street in the city centre of York, in England.

History
The site street lay mostly within the walls of Roman Eboracum, and two Anglo-Saxon carved stones and a large coin hoard have been discovered in excavations in the area.  The location formed part of St Leonard's Hospital in the Mediaeval period, which from 1546 until 1698 was a royal mint, leading to the area becoming known as "Mint Yard".  In 1675, Mint Yard was bought by the Corporation of York, for £543.

The construction of the street was proposed in 1831, with the intention that it would be built up with "genteel private residences".  The street runs across the line of the York city walls, a section of which were demolished, along with the barbican of Bootham Bar.  Although there were plans to entirely demolish Bootham Bar, this did not occur.  The street opened in 1835, and construction of the houses was completed in 1842.

In 1844 workmen digging a drain discovered a hoard of c.10,000 Northumbrian stycas, many of which were subsequently sold privately. However a portion of the hoard is now part of the collection at the Yorkshire Museum.

The expense of constructing the street left the York Corporation in debt.  This included paving the street with Macadam, and providing a new facade for the York Theatre Royal, which had previously faced Little Blake Street, but from 1835 had its main entrance on St Leonard's Place.  The street became a popular area for entertainment, with the York Subscription Library opening in 1836, the Yorkshire Club operating for a time at 5 St Leonard's Place, and the De Grey Rooms, used for concerts and meetings, opening in 1842.  The new York and North Midland Railway opened its head office on the street.  Initial residents included the Recorder of York, C. H. Elsby; the town clerk, Robert Davies; and the architect John Harper.

In 1933, the 99-year leases on many houses on the street expired, and the Corporation of York then turned the street's main terrace into council offices.  It left the terrace in 2013, after which it was converted back into housing.  The street forms part of York's inner ring road, and although the council have investigated pedestrianising it, this would require provision of an alternative route, including a new bridge across the River Ouse.

Layout and architecture

The street runs north, from the junction of Blake Street, Duncombe Place and Museum Street, gently curving to Exhibition Square, where it meets High Petergate and Bootham.

Much of the western side of the street is taken up by the terrace of 1-9 St Leonard's Place, designed by John Harper and completed in 1834.  There is also a small garden with a stretch of the Roman city wall, before the street opens up into Exhibition Square.  On the eastern side lie De Grey House, completed in 1835, and for many years from 1909 the York Conservative Club; the De Grey Rooms; and the York Theatre Royal.

References

Streets in York
The General American Investors Company, Inc. () is a closed-end fund that manages a global portfolio of investments, consisting mainly of United States securities, and also some international and private securities.

History

The General American Investors investment trust was launched in 1927 under the sponsorship of Lazard Frères and Lehman Brothers.  In its first year of operation, it earned $1.1 million.  In September 1928, Lazard Frères and Lehman Brothers launched a second fund, named the Second General American Investors Company.  In August 1928, the two funds merged, to form the current General American Investors Company, with Lazard Frères and Lehman Brothers underwriting the $40 million deal.

The early years of the Great Depression were difficult for the fund, but the fund recovered as the 1930s progressed.  The fund had assets valued at $15 million in 1932; at $23.1 million in 1933; and $30.1 million in 1935.  Assets dropped to $24.7 million in 1937; $30 million in 1939; then dropped to $25.5 million in 1943; dropping slightly to $25.3 million in 1945.

Leadership

Chairmen of the General American Investors Company

Frank Altschul, 1948-1961 
Arthur G. Altschul, 1961-1995
Lawrence B. Buttenwieser, 1995-2007
Spencer Davidson, 2007–Present

Presidents / Portfolio Managers of the Fund

Frank Altschul, 1927-1948
Harold F. Linder, 1948-1955
Harry G. Friedman, 1955-1961
Malcolm B. Smith, 1961-1989
William J. Gedale, 1989-1995
Spencer Davidson, 1995–Present

References

Financial services companies established in 1927
Companies listed on the New York Stock Exchange
Investment companies of the United States
Amshipora or Amshi Pora (locally known as Amashpur) is a village situated in Shopian district of Jammu and Kashmir, India.

Geography 
It is situated  away from district headquarters Shopian. The village is connected to Shopian by a metalled road. The village is bounded by Saidpora Bala and Saidpora Payeen in the north, Vehil-Shamsipora in the east, Ramnagri (Jumnagar) in the south and Sedow in the west.

Economy 
The main occupation of its people is cultivation of fruits, especially apples.

Resistance 
Amshi Pora, along with its neighbour Jamnagri, is a hotbed of Post-Burhan resistance against India. Militants from Amshipora include Waseem Wagay, Aetimaad Malik, Shahijahan,junaid ayoub, shariq ayoub,sameer sofi,saqibsofi, sameer sofi was declared as hybrid miltant after killed in an operation

2020 murders 
On 18 July 2020, three Kashmiri laborers from Pir Panjal Kashmir, one a minor, were murdered by Indian military personnel of the Rashtriya Rifles in the village. According to a police report, the encounter was staged by Cap. Bhopendra Singh of 62 RR for the purpose of a cash reward and promotion.and In year 2022 another civilian (shakeel ahmad khan)was killed in an operation along with a huge property loss he was the father of 3 children

Demographics 
According to 2011 Census of India, Amshipora hosts 268 households, with a population of 1,712. Islam is the religion of its entire population.

References 

Villages in Shopian district
Nathaniel Dearborn (1786–1852) was an engraver in 19th-century Boston, Massachusetts. He was born in New England in 1786 to inventor Benjamin Dearborn; siblings included John M. Dearborn and Fanny Dearborn Hanman. In Boston he learned engraving from Abel Bowen. By 1814 Dearborn worked from quarters on School Street; later moving to Market Street (ca.1823), State Street (ca.1826-1831) and Washington Street (ca.1832–1852). Around 1830, he also gave musical lessons on the flute.

He died November 7, 1852, in South Reading. His son, Nathaniel S. Dearborn, continued as an engraver and printer in Boston, working on Water Street (ca.1847–1851) and School Street (ca.1857-1868). N.S. Dearborn exhibited several printed specimens in the 1850 exhibition of the Massachusetts Charitable Mechanic Association. His grandson S.B. Dearborn also worked as a printer.

Works by Dearborn
 Views from the Mass. State House, Boston. ca.1838.
 American Textbook for Letters. 1842.
 Boston Notions; an Account of That Village from 1630 to 1847. 1848
 Dearborn's Reminiscences of Boston, and Guide through the City and Environs. 1851
 Dearborn's Guide through Mount Auburn. 1857

References

Images

External links

 WorldCat. Dearborn, Nathaniel 1786-1852

1786 births
1852 deaths
American engravers
Artists from Boston
19th-century American people