Samantha912/NLP_A2_WTH huggingface dataset:
Syntaxins are a family of membrane integrated Q-SNARE proteins participating in exocytosis.

Domains 
Syntaxins possess a single C-terminal transmembrane domain, a SNARE domain (known as H3), and an N-terminal regulatory domain (Habc). 
Syntaxin 17 may have two transmembrane domains.
 The SNARE (H3) domain binds to both synaptobrevin and SNAP-25 forming the core SNARE complex.  Formation of this stable SNARE core complex is believed to generate the free energy required to initiate fusion between the vesicle membrane and plasma membrane.
 The N-terminal Habc domain is formed by 3 α-helices and when collapsed onto its own H3 helix forms an inactive "closed" syntaxin conformation. This closed conformation of syntaxin is believed to be stabilized by binding of Munc-18 (nSec1), although more recent data suggests that nSec1 may bind to other conformations of syntaxin, as well.  The "open" syntaxin conformation is the conformation that is competent to form into SNARE core complexes.

Function 

In vitro syntaxin per se is sufficient to drive spontaneous calcium independent fusion of synaptic vesicles containing v-SNAREs.

More recent and somewhat controversial amperometric data suggest that the transmembrane domain of Syntaxin1A may form part of the fusion pore of exocytosis.

Binding 
Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. Direct syntaxin-channel interaction is a suitable molecular mechanism for proximity between the fusion machinery and the gates of Ca2+ entry during depolarization of the presynaptic axonal boutons.

The Sec1/Munc18 protein family is known to bind to Syntaxin and regulate Syntaxins machinery. Munc18-1 binds to Syntaxin 1A via two distinct sites referred as N-terminus binding and "closed" conformation that incorporates both the central Habc domain and the SNARE core domain. Munc18-1 binding to the N-terminus of Syntaxin-1 is thought to facilitate Syntaxin-1 interaction with another SNARE, while binding to the "closed" conformation of Syntaxin-1 is believed to be inhibitory.

Recently published data show that alternative spliced Syntaxin 1 (STX1B) which lacks the transmembrane domain localizes in the nuclei.

Genes 
Human genes encoding syntaxin proteins include:

 STX1A, STX1B, STX2, STX3, STX4, STX5, STX6, STX7, STX8,
 STX10, STX11, STX12,  STX16, STX17, STX18, STX19

See also 
 Tomosyn, a syntaxin binding protein

References

External links 
 

Single-pass transmembrane proteins
Lady Lu ( 4th century) was the wife of Zhang Mao (張茂; not to be confused with the Former Liang ruler of the same name, Zhang Mao), a military general of the Jin dynasty (266–420). She was noted to have commanded soldiers during Wang Dun's Insurrection in 324, siding with Emperor Ming of Jin's forces against the paramount leader, Wang Dun.

Life 
Lady Lu was a native of Wu Commandery and was married to Jin's Administrator of Wu, Zhang Mao. In 322, a civil war broke out between Emperor Yuan of Jin and his powerful commander, Wang Dun. During the war, one of Wang Dun's closest associates, Shen Chong, invaded and captured Wu Commandery. While doing so, he killed Zhang Mao and three of his sons. By the end of the year, Wang Dun had defeated Emperor Yuan's forces and taken control of the Jin government.

In 324, Emperor Yuan's successor, Emperor Ming, began a coalition against Wang Dun to restore imperial rule. Wanting to enact revenge, Lady Lu exhausted her family's wealth to join the campaign against Shen Chong. She served in the forefront of the campaign, commanding over her husband's former troops. She and the other loyalist generals defeated Shen Chong by September 324, and he was later killed by a former subordinate of his, Wu Ru (吳儒).

After Wang Dun and Shen Chong's defeat, Lady Lu visited the palace, where she wrote a letter to Emperor Ming apologizing on Zhang Mao's behalf for having lost his commandery to Shen Chong. Emperor Ming thus issued an edict stating, "Zhang Mao and his wife were both loyal and sincere, and their family have sacrificed greatly for the state's cause. It is only apt that Zhang Mao be posthumously gifted the office of Minister Coachman."

References 

 Fang, Xuanling (ed.) (648). Book of Jin (Jin Shu).

4th-century Chinese women
Women in 4th-century warfare
Women in ancient Chinese warfare
Jin dynasty (266–420) generals
People from Jiangsu
Generals from Jiangsu
Mustapha Sangaré (born 24 December 1998) is a French professional footballer who plays as a forward for  club Amiens.

Career
An amateur footballer for most of his early career, Sangaré signed a professional contract with Amiens SC on 6 November 2020. He first joined local club La Camillienne at age fifteen, where he started to coach kids at the age of seventeen. In doing so, he climbed 10 divisions from the start of the career into the Ligue 2. Sangaré made his professional debut with Amiens in a 0–0 Ligue 2 tie with Ajaccio on 22 December 2020.

On 30 September 2022, Sangaré was loaned to Borgo.

References

External links
 

1998 births
Footballers from Paris
Black French sportspeople
French sportspeople of Senegalese descent
Living people
French men's footballers
Men's association football forwards
Racing Club de France Football players
Amiens SC players
FC Borgo players
Ligue 2 players
Championnat National players
Championnat National 3 players
Dancer's Delight is a Scottish soft-shoe step dance devised in 1964 to commemorate the first anniversary of the United States Highland Dancers' Association. The dance is performed to 2/4 marches, e.g., Scotland the Brave. Dance instructions were published by Ron Wallace in 1994. Unlike softer Scottish ladies' step dances, e.g., The Thistle, Dancer's Delight resembles a Scottish highland dance in terms of style and technique.

Notes

External links

 UKA Scottish Step Dance Syllabus 2012

Scottish step dances
Scottish Highland dance
"Healing Hands" is a song by English musician Elton John, written by John and Bernie Taupin, from John's 1989 album, Sleeping with the Past. The single was released during late summer 1989 and was a top-20 hit in the United States. A reissued version (paired as a double A-side single with "Sacrifice") became the singer's first solo number-one single in the United Kingdom.

The song was inspired by the Four Tops song "Reach Out, I'll Be There". Produced by Chris Thomas, it was the first of three singles released from the album, with the follow-ups being "Sacrifice" and "Club at the End of the Street".

Release and reception
"Healing Hands" did moderately well as a single in the United States, climbing to  13 on the Billboard Hot 100 and reaching No. 1 on the Billboard Adult Contemporary chart on the week of 21 October 1989. The song failed to make the UK top 40 during its initial release, as did the follow-up, "Sacrifice". However, after Steve Wright of BBC Radio One added "Sacrifice" to his station's playlist, "Sacrifice" was re-released in the UK as a double A-side with "Healing Hands". The double A-side record topped the UK Singles Chart for five weeks starting 23 June 1990, becoming the first solo No. 1 hit of Elton John's career in his native country.

Cash Box reviewed the single saying that "Elton has gone back to basics, and delivers a great song this time, relying only on a piano and his golden throat to get him through."

Music video
The music video filmed in black and white features John singing with backgrounds singers Jackson, Jenkins and Jeter standing on platforms with black flags waving in back of them and even John in a flag as well.

Technical details
Musically, the song is complex, with the intro and verses in the key of B flat major, and the chorus in the key of D major. An instrumental solo, in the related minor key of G (minor), serves as a bridge.

Personnel 
 Elton John – keyboards, lead and harmony vocals
 Guy Babylon – keyboards
 Fred Mandel – keyboards
 Peter Iversen – Fairlight and Audiofile programming
 Davey Johnstone – guitars, backing vocals
 Romeo Williams – bass 
 Jonathan Moffett – drums
 Natalie Jackson – backing vocals
 Mortonette Jenkins – backing vocals
 Marlena Jeter – backing vocals

Charts

Weekly charts

Year-end charts

References

 "Healing Hands", The Billboard Book of Number One Adult Contemporary Hits by Wesley Hyatt, p. 352, Billboard Books (1999).

Elton John songs
1989 singles
1989 songs
MCA Records singles
Music videos directed by Russell Mulcahy
The Rocket Record Company singles
Song recordings produced by Chris Thomas (record producer)
Songs with lyrics by Bernie Taupin
Songs with music by Elton John
UK Singles Chart number-one singles
The Famous Department Store (not to be confused with the "Famous Clothing Store", precursor to Famous-Barr and the May Department Stores Co.) was a department store in Los Angeles, California.

Famous had its origins with the Cal Hirsch & Sons Mercantile Co., founded in 1860 or 1871 depending on the source, which ran Army and Navy surplus stores in St. Louis.

After opening stores in Los Angeles starting in 1913 and later moved its headquarters there. In 1939, it took over the vacated Blackstone's Department Store building at 901 S. Broadway (designed by architect John Parkinson, built in 1917) and renovated and expanded it to  of selling space, shifting the existing 530 S. Main St. store to use mostly as a warehouse. The new Broadway store sold men's, women's and children's clothing, furnishings and accessories; shoes, drapes, furniture, drapes, household utensils and accessories and an entire floor was devoted to toys. It also has a beauty shop and lunch counter.

Morgan, Walls & Clements designed an art deco building for Famous on Pine Street in downtown Long Beach, which opened in 1929.

In 1950 the stores were sold to the J. J. Sugarman Co., a Los Angeles business investment firm, a value estimated at $3.5 million, reported by the Los Angeles Times as "one of the larges mercantile sales of its kind in recent years in California". The chain at that time consisted of eight stores: Advertising for the Famous Department Store ceases in 1952.

Stores 
Main store till 1939, then Famous Army and Navy store: 530 S. Main St., Los Angeles
Main store from 1939: 901 S. Broadway, Los Angeles
Long Beach, along shopping corridor Pine Avenue at 6th
Santa Ana, 4th and Bush
San Diego
Fullerton
Glendale, Brand at Harvard
Fresno
San Bernardino
Porterville

External links 
Blackstone Department Store Building (site of Famous Department Store), Los Angeles Conservancy
Google Street View of Long Beach store (art deco, 1929, Morgan, Walls & Clements)
"Famous Department Store, Long Beach, CA" in Pacific Coast Architecture Database

References 

Defunct department stores based in Greater Los Angeles
Art Deco architecture in California
Morgan, Walls & Clements buildings
Ice Cream Man may refer to:

 A vendor employed on an ice cream van

Music
 Ice Cream Man (album), a 1996 album by Master P
"Mr. Ice Cream Man", the title track
 "Ice Cream Man", a song by Tom Waits from his 1973 album Closing Time
 "Ice Cream Man", a song by Jonathan Richman and the Modern Lovers from their 1977 album Rock 'n' Roll with the Modern Lovers
 "Ice Cream Man", a song by John Brim, also covered by Van Halen
 "Ice Cream Man", a song by Dru Down from his 1994 album Explicit Game
 "Ice Cream Man", a song by Blur from their 2015 album The Magic Whip
 "Ice Cream Man", a song by Yungblud from his 2020 album Weird!
 "Ice Cream Man", a 2018 song by Sam and the Womp

Other uses
 Ice Cream Man (business), an American business that gives away ice cream at music events
 Ice Cream Man (film), a 1995 American horror film about an ice cream man
 Ice Cream Man (comics), a comic book series written by W. Maxwell Prince
 Ice Cream Man, a recurring gag character in Disney's Lilo & Stitch franchise
Spencer Herr (born March 1974) is an artist from Phoenix, Arizona. He currently lives in Asheville, North Carolina.

Biography

Early life
Herr grew up in Phoenix, Arizona and attended Northern Arizona University. He spent his early twenties traveling and seeking adventure throughout the US west  coast, Mexico, Australia, 
and Asia. At 26, he moved to South West Virginia where he met his wife, Kara. He lives and works in Asheville with his wife and two daughters.

Career
 In 2006, Herr began to show his art publicly. He approached Betsey-Rose Weiss the next year with a CD of his works. Upon viewing Herr's paintings, Weiss decided that he would be the first artist she would choose to represent as the new owner of an Asheville gallery.  Herr was exhibited at the 20th annual Outsider Art Fair in New York in January 2012. His work was represented at the Outsider Art Fair by Marcia Weber Art Objects, a gallery that sells a large number of his works to collectors worldwide.

Themes and materials
Much of Herr's work is laden with spiritual allusions. His interest in religion can be seen in two of his older series based on Abraham's Covenant and the poetry of 13th century Persian mystic Rumi. His series working man's mystic addresses the relationship between ego death and the desire to connect with God. His use of layering expresses an interest in the perception of memory. Herr often sacrifices realism for essence. Paintings of his daughters are not portraits of their physical characteristics, but rather they capture the girls' wonderment and innocence. Having grown up in the southwest, Herr is fascinated with rough environments. His work represents this through journalistic portrayals of states of mind, as opposed to landscapes.

External links
  - official website
 @herrspencer Instagram
www.spencerherr.com

References

 McBroom, Brenna. Spencer Herr. N.p., 2011. Web. 28 Jan. 2012. <>.
 Gold, Kelly. Into the mystic. N.p., 3 Aug. 2010. Web. 28 Jan. 2012. <http://www.mountainx.com/article/31337/Into-the-mystic>.
 Spencer Herr. N.p., n.d. Web. 28 Jan. 2012. <http://www.amerifolk.com/painting/SpencerHerr/index.php>.
 20th Annual Outsider Art Fair Showcases Intriguing Work By Self-Taught Artists. N.p., 28 Jan. 2012. Web. 28 Jan. 2012. <http://www.artsobserver.com/2012/01/28/20th-annual-outsider-art-fair-showcases-intriguing-work-by-self-taught-artists/>.
 Spencer Herr. N.p., n.d. Web. 28 Jan. 2012. <>.

Folk artists
Northern Arizona University alumni
Artists from Asheville, North Carolina
1974 births
Living people
Rachel Campbell-Johnston (born October 1963) is The Times newspaper's chief art critic.

Appointed to her post in 2002, she has also been her newspaper's poetry editor, leader writer, deputy comment editor, obituary writer and deputy books editor.

Mysterious Wisdom, her biography of artist Samuel Palmer was published in 2011. The Child's Elephant, a novel about an African boy who rears an elephant, set against the backdrop of child soldiers fighting for a rebel army was published in 2013 and shortlisted for the Carnegie Prize.

See also
 Lustfaust

References

External links
Journalisted - Articles by Rachel Campbell-Johnston

1963 births
British journalists
The Times people
Living people
Place of birth missing (living people)
British women journalists
The enzyme FAD-AMP lyase (cyclizing) (EC 4.6.1.15) catalyzes the reaction

FAD  AMP + riboflavin cyclic-4′,5′--phosphate

This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases.  The systematic name of this enzyme class is FAD AMP-lyase (riboflavin-cyclic-4′,5′-phosphate-forming). Other names in common use include FMN cyclase and FAD AMP-lyase (cyclic-FMN-forming).

References

Further reading 

 
 

EC 4.6.1
Enzymes of unknown structure
This is a list of the songs that reached number-one position in official Polish single chart in ZPAV in 2010.

Chart history

Number-one artists

See also 
 List of number-one dance singles of 2010 (Poland)
 List of number-one albums of 2010 (Poland)

References 

Number-one singles
Poland
2010
Frederick Archibald Burgon (born 28 March 1912 in Nottingham–died 1994) was a professional footballer who played for Colwick, Burton Joyce, Grantham Town, Notts County, Newark Town, Tottenham Hotspur, Wrexham and Carlisle United.

Football career 
Burgon played for non League football clubs Colwick, Burton Joyce and Grantham Town before being given a trial at Notts County in 1930. After a spell with Newark Town the outside left returned to Notts County in 1932 where he featured in 26 matches and scoring seven goals. He went on to play for Grantham for a second time before signing for Tottenham Hotspur in 1934. Burgon played a total of four matches for the Lilywhites. In 1935, Burgon joined Wrexham where he went on to make 140 appearances and score 36 goals between 1935 and 1938. Burgon ended his career at Carlisle United where he appeared in a further two matches.

References 

1912 births
1994 deaths
Footballers from Nottingham
English men's footballers
English Football League players
Grantham Town F.C. players
Notts County F.C. players
Tottenham Hotspur F.C. players
Wrexham A.F.C. players
Carlisle United F.C. players
Newark Town F.C. players
Men's association football outside forwards
West 117th–Madison station is a station on the RTA Red Line in Cleveland, Ohio. It is located on the border between Cleveland and Lakewood.

The station is located on the southeast corner of Madison Avenue and West 117th Street. The border between Cleveland and Lakewood runs down West 117th Street. As originally constructed, it included a bus loop adjacent to West 117th Street and a parking lot to the east. The station has undergone renovation and reconstruction, making it accessible to people with disabilities.

History 
The station was the original western terminus of the CTS Rapid Transit when the west side portion of the line opened on August 14, 1955. The line was extended  west to Triskett station on November 15, 1958.

In late 2005, RTA began rebuilding the station, which was expected to take two years. After the $4.7-million renovation, the new station was dedicated on October 16, 2007. 

Upon rededication, the name of the station was to be changed to Highland Square at West 117th Street, but the West 117th–Madison name had been retained with Highland Square name attached. Highland Square refers to a neighborhood name used in the 19th century. As of 2017, the Highland name has been removed.

Station layout

Notable places nearby 
 Lakewood
 Kirby Company
 Phantasy Theater
 St. Edward High School

Gallery

References

External links 

 W. 117 – Madison Rapid Station

Red Line (RTA Rapid Transit)
Railway stations in the United States opened in 1955
1955 establishments in Ohio
Jönssonligan största kupp (English: The Jönsson Gang's Greatest Robbery) is a Swedish film about the gang Jönssonligan, released to cinemas in Sweden on 3 February 1995.

Cast

External links
 
 
 

Jönssonligan films
1995 films
Swedish comedy films
Films set in Warsaw
1990s Swedish films
Yana Uqsha (Quechua yana black, uqsha high altitude grass, Hispanicized spellings Yana Ucsha, Yanahucsha, Yanahojsha, Yanaocsha, Yanaucsha, Yanauscha, also Yanauksha) may refer to:

 Yana Uqsha, a mountain at a little lake of that name in the Junín Region, Peru
 Yana Uqsha (Ayacucho), a mountain in the Ayacucho Region, Peru
 Yana Uqsha (Cajatambo), a mountain in the Cajatambo Province, Lima Region, Peru
 Yana Uqsha (Lima), a mountain in the Huaral Province, Lima Region, Peru
The KGP-9 is a Hungarian submachine gun used by Hungary's military forces and prison guards. It operates using a basic blowback mechanism, and fires the very popular 9mm Parabellum cartridge from a closed bolt.  It is assembled from pressed steel, reinforced with castings.  The KGP-9 fires with a hammer mechanism and with a floating firing pin contained in the bolt, and is capable of a firing rate of 900 rounds/min.

The standard issue barrel can be replaced by a longer one, turning the gun into a carbine with longer range than a submachine gun.  The civilian variant is the KGPF-9, it is capable of semi-automatic fire only.

References
 Military Small Arms of the 20th Century by Ian Hogg and John Weeks

9mm Parabellum submachine guns
Submachine guns of Hungary
Fegyver- és Gépgyár firearms
Field marshal () was usually the highest military rank in various German armed forces. It had existed, under slightly different names, in several German states since 1631. After the unification of Germany it was the highest military rank of the Imperial German Army and later in the Wehrmacht until it was abolished in 1945.

The vast majority of the people promoted to field marshal won major battles in wars of their time. Field marshals played a compelling and influential role in military matters, were tax-exempt, members of the nobility, equal to government officials, under constant protection or escort, and had the right to directly report to the royal family. In the Prussian military tradition, which set the tone for the 19th century and the German Empire, field marshals could only be promoted in wartime and the royal family was excluded, both resulting in the creation of the rank of colonel general with the rank of general field marshal () in 1854. Both restrictions would eventually end with the first royals being promoted during the Franco-Prussian War in 1870, and later honorary promotions to foreign monarchs would follow. Adolf Hitler effectively disregarded the wartime prerequisite by two promotions in 1936 and 1938, though all subsequent promotions were during wartime.

Electorate (1356–1806) and Kingdom of Saxony (1806–1918)

Brandenburg-Prussia and the Kingdom of Prussia (1701–1870)

German Empire (1871–1918)

Weimar Republic (1918–33)
After the loss of the First World War, Germany was transformed into what became known as the Weimar Republic, which was subject to the terms of the Treaty of Versailles. It required the reduction of the German Army to 100,000 men, a reduction of the German Navy, and the abolition of the German Air Force. As a result of the new military arrangements, there were no field marshals created during the Weimar Republic.

Nazi Germany (1933–45)

See also
 Field marshal (United Kingdom)
 Field marshal (Russian Empire)
 List of Swedish field marshals
 List of German colonel generals

Notes

References

Sources

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
Germany
Field marshals
Belle's Good Cide (March 17, 1993 – March 8, 2003) was an Oklahoma-bred Thoroughbred racing mare best known as the dam of Funny Cide.

Background
Belle's Good Cide was a chestnut mare bred by John Smicklas. She was sired by Slewacide out of Belle of Killarney (who also produced the stakes winning Belle of Cozzene). As a yearling she was sold for $2,800 at the 1994 Heritage Place Fall sale.

Racing career
Belle's Good Cide raced for three years, starting 26 times, winning twice, and earning $26,696.

Breeding record

As a broodmare Belle's Good Side's best offspring was the gelding Funny Cide, by Distorted Humor, who won the Kentucky Derby in 2003. Her other foals included Coincide (a grey colt by Cozzene) and Rockside (a bay filly by Personal Flag

In December 2001 she was consigned to the Fasig-Tipton Midlantic mixed sale and was bought for $3,500 by the Boniface family's Bonita Farm agentShe finished her life at McMahon of Saratoga Thoroughbreds in Saratoga Springs, New York where Funny Cide was born.

Belle's Good Cide was euthanized due to complications from colic in 2003 just after giving birth to her fourth foal, a chestnut colt by Mojave Moon and bred by Bonita Farm of Maryland.  This happened shortly before Funny Cide's Kentucky Derby and Preakness Stakes victories.  The foal was called Homicide and began racing in the year 2006. In 2008 he proved to be a successful point to point horse in Maryland.

References

  Pedigree & Partial Stats

1993 racehorse births
2003 racehorse deaths
Racehorses trained in the United States
Racehorses bred in Oklahoma
Thoroughbred family 6-d