Samantha912/NLP_A2_WTH huggingface dataset:
Nitroreductases are a  family of evolutionarily related proteins involved in the reduction of nitrogen-containing compounds, including those containing the nitro functional group. Members of this family utilise flavin mononucleotide as a cofactor and are often found to be homodimers.

Members of this family include oxygen-insensitive NAD(P)H nitroreductase (flavin mononucleotide-dependent nitroreductase) (6,7-dihydropteridine reductase) () and NADH dehydrogenase (). A number of these proteins are described as oxidoreductases. They are primarily found in bacterial lineages though a number of eukaryotic homologs have been identified: C. elegans , D. melanogaster ,  , mouse  and human . This protein is not found in photosynthetic eukaryotes. The sequences containing this entry in photosynthetic organisms are possible false positives.

The nitroreductase of Enterobacter cloacae was identified by Bryant and Deluca in a strain isolated from a munitions facility, on the basis of its ability to metabolize TNT (trinitrotoluene).  Since then many homologues have been identified and the family is now known to include members in diverse organisms, that catalize diverse reactions.  The iodotyrosine deiodenase of mammals is a dehalogenase, the BluB of Sinorhizobium meliloti cannibalizes the bound flavin mononucleotideto furnish a critical intermediate in vitamin B12 biosynthesis.

Crystal structures of the E. cloacae and E. coli enzymes have been published with a variety of substrates and analogues bound.

An example of a potential cold-active enzyme for prodrug therapy was described using a cold-active nitroreductase, Ssap-NtrB (Çelik and Yetis, 2012). Despite Ssap-NtrB derived from a mesophilic bacterium, it showed optimal activity at 20°C against cancer prodrugs. Authors comment that the cold-activity of this novel enzyme will be useful for therapies in combination with crymotherapy, exposing the target tissue to low temperatures in order to trigger the enzyme activity to activate the drug only where is required. Moreover, the enzyme could also be used for bioremediation of compounds of explosive and volatile nature in regions where high activity at low temperatures is needed.

Subfamilies
Cob(II)yrinic acid a,c-diamide reductase

Human proteins containing this domain 
IYD;

References 

Protein domains
Single-pass transmembrane proteins
The Invester (1969–2002) was a Quarter Horse stallion who excelled at halter and at western pleasure, as well as being a famous sire of western pleasure horses.

Life

The Invester was a 1969 sorrel son of Zippo Pat Bars and out of a linebred daughter of Dinky Reed named Hank's Peppy Lou. Hank's Peppy's Lou's dam Logan's Miss Lue, and she was out of a daughter of Dinky Reed.

Jerry Wells bought The Invester as a weanling at the Oklahoma State Fair in 1969. Later, he described the horse as "He was a cherry-red sorrel with stockinged legs, a real pretty head and neck, and lots of body and muscle. He was also straight and correct and a good-minded colt." Wells, however, felt that the original registered name of Hank Lou Bars wasn't a good fit for the colt, and renamed him with the American Quarter Horse Association (or AQHA) as The Invester.<ref name=Campbell>Campbell "Chairman of the Board" Quarter Horse Journal" p. 12</ref>

 Show career 
During his show career, The Invester earned an AQHA Superior Halter Horse award as well as an AQHA Championship and an AQHA Performance Register of Merit. He earned points in Halter, Cutting, English Pleasure, Western Pleasure, and Reining. Although known for being a halter horse, in 1972 The Invester missed making the finals of the National Cutting Horse Association Futurity semi-finals by just one point.

 Breeding record 
Among The Invester's offspring are The Appraiser, Double Vested, El Cicatriz, Bonafid, Investers Skip, The Stockbroker, The Big Investment, Vested Pine, Assets, and Impulsions. His offspring The Big Investment and Impulsions were inducted into the National Snaffle Bit Horse Hall of Fame, along with his grandget January Investment. In 1980, his offspring placed first through fourth in the All American Quarter Horse Congress Two-Year-Old Western Pleasure Futurity.

 Death and honors 
The Invester was the second Quarter horse stallion to be syndicated."There's Fixin to be an Invester Revival" Southern Horseman pp. 20–21 In 1994 he was inducted into the National Snaffle Bit Association Hall of Fame. He was humanely put down on February 28, 2002, due to old age. The Invester was inducted into the AQHA Hall of Fame in 2004.

Pedigree

Notes

References

 All Breed Pedigree Database Pedigree for The Invester accessed on June 26, 2007
 https://www.aqha.com/hall-of-fame AQHA Hall of Fame] accessed on September 2, 2017
 
 
 
 NSBA Hall of Fame'' accessed on July 5, 2007

External links
 The Invester at Quarter Horse Directory
 The Invester at Quarter Horse Legends
 The Invester at Dan McWhirter Quarter Horses

American Quarter Horse show horses
American Quarter Horse sires
1969 animal births
2002 animal deaths
AQHA Hall of Fame (horses)
The Mumbles lifeboat disaster occurred in 1947 off south Wales when the Mumbles lifeboat was undertaking a rescue off Sker Point but was overwhelmed by the sea with the loss of all eight lives in the lifeboat.

History
Mumbles Lifeboat station is situated at the western end of Swansea Bay in the village of Mumbles. At the time of the disaster the Lifeboat operating there was RNLB Edward, Prince of Wales (ON 678).

On 23 April 1947 the  en route from Middlesbrough to Newport decided to stop at Sker Point on the Glamorgan coast not far from Porthcawl. Its three anchor cables were unable to hold the ship in the gale raging at the time and the ship foundered on the rocks, breaking into three.

The Mumbles lifeboat, in attempting a rescue, was believed to have been overwhelmed by a freak wave and all the crew were drowned. Memorials to the crew stand in the churchyard of All Saints' Church, Oystermouth.

A memorial service was held in Swansea attended by the Duke of Kent on the 50th anniversary of the disaster.

References

Maritime incidents in Wales
April 1947 events in the United Kingdom
1947 in Wales
History of Swansea
Swansea Bay
Disasters in Wales
Maritime incidents in 1947
1947 disasters in the United Kingdom
Robinsonekspedisjonen: 2001, was the third season of the Norwegian version of the Swedish show Expedition Robinson and it premiered on 9 September 2001 and aired until 2 December 2001. The third season took place on an island in Malaysia. In episode five of this season, the first twist took place which was a tribal swap took place. Along with this twist starting in episode five the tribe that won immunity voted out a member of the losing tribe. When the merge came so did the season's joker, Annbjørg Østerås who along with Conny Hansen and Erik Torjusen moved to a new, merge camp in episode 6. For the first time in the history of Expedition Robinson, there was a final three instead of a final two and for the first time in the Norwegian version of the show the public were allowed to award a jury vote to the finalist of their choice. Ultimately, Mia Martinsen won the season with a jury vote of 4-3-2 over Trude Hole and Anders Dahle

Finishing order

External links
http://www.dagbladet.no/kultur/2001/08/23/276783.html?i=2
http://www.dagbladet.no/kultur/2001/08/23/276782-15.html

 2001
2001 Norwegian television seasons
Pery Igel (November 27, 1921 – September 24, 1998) was a Brazilian businessman. Igel was Ultra's second president, succeeding his father and company's founder, Ernesto Igel.

Biography
Igel was the administrator and second president of Ultra. He took over the company created by his father, Ernesto Igel, in 1959. After two years as president, Igel moved the headquarters from Rio de Janeiro to São Paulo, Brazil. Under Pery's administration, Oxiteno and Ultracargo were founded, two of the five divisions of Ultra, along with Ultragaz (first division of Ultra), as well as Ipiranga and Extrafarma, which were incorporated to the group respectively in 2007 and 2014.

Under his administration, the company created and also dissociated a number of other activities that have stopped being related to Ultra's long-term strategy, such as a domestic appliances retailer (Ultralar), an engineering company (Ultratec), a frozen food organization (Supergel,) and the fertilizer industry (Ultrafértil.)

Igel stepped down as CEO in 1981 and appointed Vice President Paulo Cunha to the position. Igel became president of the Ultra's board of directors and remained its main shareholder.

Before his death in September 1998, Igel transferred the controlling shares of Ultra to his family and to a small group of Ultra executives through the creation of a holding company.

References

20th-century Brazilian businesspeople
Brazilian people of Austrian descent
1921 births
1998 deaths
Igel family
The canton of Maringues is an administrative division of the Puy-de-Dôme department, central France. Its borders were modified at the French canton reorganisation which came into effect in March 2015. Its seat is in Maringues.

It consists of the following communes:
 
Bas-et-Lezat
Beaumont-lès-Randan
Charnat
Châteldon
Lachaux
Limons
Luzillat
Maringues
Mons
Noalhat
Paslières
Puy-Guillaume
Randan
Ris
Saint-André-le-Coq
Saint-Clément-de-Régnat
Saint-Denis-Combarnazat
Saint-Priest-Bramefant
Saint-Sylvestre-Pragoulin
Villeneuve-les-Cerfs

References

Cantons of Puy-de-Dôme
Dhur or D°ur (Dzongkha: དུར་; Wylie: dur) is a town in western Chhoekhor Gewog, Bumthang District in central Bhutan.

Dhur is the main area where Brokkat, one of the endangered languages of Bhutan, is spoken.

References

External links
Satellite map at Maplandia.com

Populated places in Bhutan
Bumthang District
Muhmmadu Tambari reigned as Sultan of Sokoto from 1924 to 1931, he was deposed in 1931. Tambari was the son of Muhammadu Maiturare.

Life

Prior to his selection as Sultan, Tambari was the Sarkin Gobir of Gwadabawa; his selection as Sultan was influenced by the Lieutenant Governor, William Gowers and Webster, the British resident in Sokoto. Tambari's major competitor was Hassan, Sarkin Barau of Dange who was eleven years older than Tambari and who was the preferred choice of the Sokoto traditional council led by  Waziri Maccido. However, the masses were indifferent to the choice of Tambari over Hassan, Tambari's father was respected for his kindness and they hoped his son will be kind like his father. During his reign, he did not enjoy loyalty from many of his officials due to the lack of support for his candidacy by notable men in Sokoto but depended on the support of the British to go along with his duties.
Tambari consolidated his hold by firing or asking disloyal officials to resign, the first major official to resign was Waziri Maccido who resigned in September 1925, some other officials dismissed were Usman the Magajin Garin of Sokoto, the chief Alkali and Usman the majidadi. He replaced Maccido with Abdulkadiri as acting Waziri, this was done despite the fact the new Waziri was not from the venerated Gidado line and despite the British resident's contemptuous attitude towards Abdulakdiri. However, three years later and on the advice of the British, he appointed Abbas as the new Waziri, Abbas had the support of notable family in Sokoto but he was not well liked by Tambari.
Prominent among the children of Sultan Tambari was Sarkin Gobir Adiya.

Deposition
Up until July, 1930, Tambari's relationship with the British residents had been cordial, but in July 1930, allegations of miscarriage of justice, issuing usurious loans to district heads and consultation with African traditional religion practitioners was levied against him. Further, in October 1930, frivolous accusations were made against him by unknown persons. The allegations were investigated in late 1930 and Tambari deposed.

References

Sultans of Sokoto
Polish campaign stars were established on 14 June 2007 to recognize military and civilian participants of overseas missions since 2002.  Polish personnel must have been present for at least one day.  Foreigners may be presented with a campaign star for collaborating with Polish forces during the mission.

Appearance
The medal is 44 mm across in a bronze patina in the shape of a four pointed star.  Behind the star are two crossed swords, blades pointing upward. The raised monogram of the letters "RP" is found in the top arm of the star. In the middle of the star is the name of a country or a geographical area for operations. On the lower arm and between the upper arms are stylized laurel leaves. The reverse contains the two-line inscription "PACI SERVIO" (Service to peace) in the center of the star, with a place below for engraving dates of service.

The award is suspended on the ribbon in the color defined for each individual star, in a width of 35 mm, with a red stripe width of 4 mm through the center, which has white stripes on the sides of a width of 2 mm and symmetrically arranged along the edges of connected strips or stripes in the colors of the flag state or area.

Clasps may be awarded for a specific military operation or for repeated deployments. Clasps are horizontal bars 38 mm wide and 5 mm tall.  They are in a dull, brown patina, with polished edges, a polished Arabic numeral, or the name of a specific military operation. Ribbon bars are identical to the ribbon suspending the star.

Polish Campaign Stars:

See also
 Orders, decorations and medals of Poland

References

External links 
 Act of 14 June 2007 amending the Act of 16 October 1992 medals and decorations. (Official Gazette No. 123 of 9 July 2007, pos. 848) (Polish)
 Polish President Regulation of 31 July 2007 amending Regulation of 10 November 1992 on the description, material, dimensions, designs, drawings and how to wear badges and the circumstances of orders and decorations. (Official Gazette No 151 of 22 August 2007, pos. 1075) (Polish)
 Military decorations (including Polish Campaign Stars) at the President of Poland site (Polish)

Military awards and decorations of Poland
Passiflora herbertiana, or native passionfruit, is a widespread climbing twiner native to moist forests on the coast and ranges of eastern Australia. The subspecies P. h. insulae-howei P.S.Green is endemic to Lord Howe Island in the Tasman Sea.

Description
The leaves are usually 3-lobed usually with a slightly hairy undersurface; 6–12 cm long; with petioles mostly 1.5–4 cm long, with 2 glands at the apex. Stipules are linear, mostly 1–3 mm long. The flowers are 6 cm wide and yellow to orange. The following green berry is 50 mm long with pale spots.

The insulae-howei subspecies is similar: the leaves are usually 4–8 cm long and 5–8 cm wide. The solitary, orange-yellow to greenish flowers, 60 mm across, appear from October to March. The oval green fruits are 40–50 mm long; they are edible but sickly-sweet.

Distribution and habitat
The insulae-howei subspecies is endemic to Australia’s subtropical Lord Howe Island in the Tasman Sea, where it is widespread.

Flammability & building protection
Passiflora herbertiana is included in the Tasmanian Fire Service's list of low flammability plants, indicating that it is suitable for growing within a building protection zone.

References

herbertiana
Malpighiales of Australia
Flora of New South Wales
Flora of Queensland
Plants described in 1823
The 1978 NC State Wolfpack football team represented North Carolina State University during the 1978 NCAA Division I-A football season. The team's head coach was Bo Rein. NC State has been a member of the Atlantic Coast Conference (ACC) since the league's inception in 1953. The Wolfpack played its home games in 1978 at Carter Stadium (now Carter–Finley Stadium) in Raleigh, North Carolina, which has been NC State football's home stadium since 1966.

Schedule

Roster

References

NC State Wolfpack
NC State Wolfpack football seasons
Citrus Bowl champion seasons
NC State Wolfpack football
The New Hampshire Bank Building is a historic commercial building at 22-26 Market Square, Portsmouth, New Hampshire. Built in 1803 and much altered since, it is one of the nation's oldest purpose-built bank buildings, and was until 1977 the oldest building used continuously to house banking operations. It was added to the National Register of Historic Places in 1979.

Description and history
The New Hampshire Bank Building is prominently sited in downtown Portsmouth's Market Square, on the east side of the square, one building south of Daniel Street. Due to its extensive history of alteration, the building now has two different facades, one next to the other. When built, it was a two-story brick structure, with a five-bay front facade, of which the center three bays were recessed. The recessed area was covered by a roof, which sheltered entrances into the projecting outer bays. In 1869 the building was partitioned into two ground-floor spaces, with front-facing entrances to those, and a third center entrance providing access to the upper floor. In 1903 the building was widened, and the left side restyled in the Classical Revival. The right side was renovated in 1904, giving that half a granite Beaux Arts facade. In the  lobby hangs a giant stained glass dome depicting the New Hampshire State Seal.

The building was erected in 1803 for the New Hampshire Bank after a house which was serving as its office burned in the great fire of 1802. New Hampshire Bank, chartered in 1792, was the first bank in the state. The building's ground floor spaces were occupied by a succession of banking interests, including two different banks beginning with the 1869 partition. Among those occupying offices on the second floor were New Hampshire Governor Levi Woodbury, his pupil, later President, Franklin Pierce, and New Hampshire Attorney General Jeremiah Mason. All three were U.S. senators from New Hampshire for one or more terms.

The building was occupied by banks until 1977, when it was sold to a real estate agent, who adapted one side for his agency, and leased the other to a mortgage broker. The building now houses non-banking commercial businesses.

See also
National Register of Historic Places listings in Rockingham County, New Hampshire

References

Bank buildings on the National Register of Historic Places in New Hampshire
Neoclassical architecture in New Hampshire
Beaux-Arts architecture in New Hampshire
Commercial buildings completed in 1803
Buildings and structures in Portsmouth, New Hampshire
Commercial buildings in New Hampshire
National Register of Historic Places in Portsmouth, New Hampshire
Chiranjeevi is an Indian actor and producer who works predominantly in Telugu cinema. He has also appeared in Hindi, Tamil and Kannada films. He made his acting debut in 1978, with the film Punadhirallu. However, Pranam Khareedu was released earlier at the box office. Known for his break dancing skills, Chiranjeevi has starred in more than 150 feature films. He rose to stardom after playing the lead in the action film Khaidi (1983). His 1987 film Swayamkrushi premiered at the Moscow International Film Festival. He co-produced Rudraveena (1988), which won the National Film Award for Best Feature Film on National Integration. In a film career spanning forty-five years, he has won four state Nandi Awards and nine Filmfare Awards South.

In 2006, Chiranjeevi was honoured with the Padma Bhushan, India's third highest civilian award, for his contributions to Indian cinema, and was presented with an honorary doctorate from Andhra University. In 2013, he inaugurated the Incredible India Exhibition, a joint participation of the Ministry of Tourism and Ministry of Information and Broadcasting at the 66th Cannes Film Festival. He also represented Incredible India at the 14th International Indian Film Academy Awards ceremony held in Macau. In 2013, IBN LIVE named him as one of "The men who changed the face of the Indian Cinema".

Chiranjeevi's 1992 film Gharana Mogudu is the first Telugu film to gross over 10 crore at the box office. The film made Chiranjeevi the highest-paid actor in India at the time, catapulting him to the cover pages of noted national weekly magazines in India. The entertainment magazines Filmfare and India Today named him "Bigger than Bachchan", a reference to Bollywood's Amitabh Bachchan. News magazine The Week hailed him as "The new money machine". He was paid a remuneration of 1.25 crores for the 1992 film Aapadbandhavudu, the highest for any Indian actor then. In 2002, Chiranjeevi was given the Samman Award for the Highest Income Tax Payer for the assessment year 1999-2000 by the Minister of State for Finance, Government of India. A poll conducted by CNN-IBN in 2006 named Chiranjeevi the most popular star of the Telugu Film Industry.

In April 2022, Chiranjeevi starred in Acharya directed by Koratala Siva co-starring Ram Charan, Sonu Sood and Pooja Hegde. His second film released in October 2022 was Godfather, in which Salman Khan and Nayanthara played supporting roles.

In 2023, he starred in Waltair Veerayya alongside Ravi Teja, Shruti Haasan and Prakash Raj. He also starred in Bhola Shankar alongside Keerthy Suresh, Tamannaah Bhatia, and Sushanth.

Film

As an actor

Telugu

Other languages

Other roles

Television

Notes

References

External links
 

Indian filmographies
Male actor filmographies