SalioSAM/toxsample11 huggingface dataset:
Poisoning cause: SEVERE Cymbalta (Duloxetine )TOXICITY
Toxic dose : in Adult :1000 mg or higher in adults.
Management:  Aggressive use of benzodiazepines and serotonin antagonists is required for more severe serotonin syndrome. Early intubation, neuromuscular paralysis, ventilation assistance, and aggressive cooling should be performed if the patient presents with severe muscle rigidity, and severe hyperthermia. Treat hypotension initially with IV fluids, add vasopressors if necessary. Treat seizures with benzodiazepines; use barbiturates or propofol for recurrent seizures. Patients with wide-complex dysrhythmias should be treated with sodium bicarbonate boluses (1 to 2 mEq/kg, monitor blood gases, target pH 7.45 to 7.55). Although QTc interval prolongation is well described, torsade de pointes is rare. If torsade de pointes occurs, patients should be treated using standard interventions (magnesium sulfate 2 g IV, external or internal cardiac pacing).
Poisoning cause: MILD TO MODERATE Lacosamide TOXICITY
Toxic dose : adverse effects have been reported with doses ranging from 400 mg to 12 g.   <50 kg:	>0.5 mg/kg,
≥50 kg:	>800 mg
Management: Treatment is symptomatic and supportive.
Poisoning cause: SEVERE Lacosamide TOXICITY
Toxic dose : adverse effects have been reported with doses ranging from 400 mg to 12 g.   <50 kg:	>0.5 mg/kg,
≥50 kg:	>800 mg
Management: Treatment is symptomatic and supportive. Patients may require airway management; closely monitor neurologic function. Treat QRS prolongation with sodium bicarbonate; an initial dose of 1 to 2 mEq/kg is reasonable. Monitor ECG and blood gases.
Poisoning cause: MILD TO MODERATE Naproxen toxicity
Toxic dose : For a patient weighing less than 50 kg, a toxic dose of Naproxen is greater than 35 mg/kg.
For a patient weighing 50 kg or more, a toxic dose of Naproxen is greater than 2000 mg.
Poisoning cause: SEVERE Naproxen toxicity
Toxic dose : For a patient weighing less than 50 kg, a toxic dose of Naproxen is greater than 35 mg/kg.
For a patient weighing 50 kg or more, a toxic dose of Naproxen is greater than 2000 mg.
Poisoning cause: MILD TO MODERATE Losartan toxicity
Toxic dose : Generally, significant symptoms are observed after ingestion of more than 5-10 times the usual therapeutic dose​​.in acute dose: 6 months - 5 years: A toxic dose of Losartan is considered to be greater than 1 mg/kg or greater than 50 mg.
6 years - 12 years: A toxic dose of Losartan is considered to be greater than 100 mg.
13 years - 18 years: A toxic dose of Losartan is considered to be greater than 150 mg.
19 years - 64 years: A toxic dose of Losartan is considered to be greater than 200 mg.
65 years - 79 years: A toxic dose of Losartan is considered to be greater than 150 mg.
Management: Administer IV fluids for hypotension.
Poisoning cause: SEVERE  Losartan toxicity
Toxic dose : Generally, significant symptoms are observed after ingestion of more than 5-10 times the usual therapeutic dose​​.in acute dose: 6 months - 5 years: A toxic dose of Losartan is considered to be greater than 1 mg/kg or greater than 50 mg.
6 years - 12 years: A toxic dose of Losartan is considered to be greater than 100 mg.
13 years - 18 years: A toxic dose of Losartan is considered to be greater than 150 mg.
19 years - 64 years: A toxic dose of Losartan is considered to be greater than 200 mg.
65 years - 79 years: A toxic dose of Losartan is considered to be greater than 150 mg.
Management: Severe toxicity has not been reported following exposure to these agents. Provide the usual supportive treatment for any symptoms and consider co-ingestion of other medical conditions.
Poisoning cause: MILD TO MODERATE valsartan toxicity
Toxic dose : 6 months - 5 years:	>3.4 mg/kg OR >80 mg,
6 years - 12 years:	>160 mg,
13 years - 18 years:	>240 mg,
19 years - 64 years:	>320 mg,
65 years - 79 years:	>240 mg
Management: Administer IV fluids for hypotension. 
Clinical effect 2: Mild hypotension
Clinical effect 3: Tachycardia
Clinical effect 4: Asymptomatic hypoglycemia
Clinical effect 5: Muscle cramps
Clinical effect 6: Dizziness
Clinical effect 7: Bradycardia 
Clinical effect 8: Hypokalemia
Poisoning cause: SEVERE  valsartan toxicity
Toxic dose : 6 months - 5 years:	>3.4 mg/kg OR >80 mg,
6 years - 12 years:	>160 mg,
13 years - 18 years:	>240 mg,
19 years - 64 years:	>320 mg,
65 years - 79 years:	>240 mg
Management: Severe toxicity has not been reported following exposure to these agents. Provide the usual supportive treatment for any symptoms and consider co-ingestion of other medical conditions. 
Clinical effect 2: Anuric renal failure
Clinical effect 3: circulatory collapse
Clinical effect 4: shock
Clinical effect 5: CNS depression
Poisoning cause: MILD TO MODERATE  Vraylar (cariprazine) toxicity
Toxic dose : The SPI triage threshold value for ingesting Vraylar (cariprazine) is as follows:
6 months - 11 years: Triage to ER if the ingested amount of Vraylar (cariprazine) exceeds 6 mg.
12 years - 79 years: Triage to ER if the ingested amount of Vraylar (cariprazine) exceeds 7.5 mg.
Management: Treatment is symptomatic and supportive. Correct any significant fluid and/or electrolyte abnormalities in patients with severe diarrhea and/or vomiting.
Poisoning cause: SEVERE Vraylar (cariprazine) toxicity
Toxic dose : The SPI triage threshold value for ingesting Vraylar (cariprazine) is as follows:
6 months - 11 years: Triage to ER if the ingested amount of Vraylar (cariprazine) exceeds 6 mg.
12 years - 79 years: Triage to ER if the ingested amount of Vraylar (cariprazine) exceeds 7.5 mg.
Management: Mainstay of treatment is good supportive care, including airway management for patients with severe CNS sedation.
Poisoning cause: MILD TO MODERATE Vyvanse (Lisdexamfetamine) toxicity
Toxic dose : The SPI triage threshold value for ingesting Vyvanse (Lisdexamfetamine) is as follows:
6 months - 5 years: Triage to ER if the ingested amount of Vyvanse (Lisdexamfetamine) is greater than 3 mg/kg OR exceeds 50 mg.
6 years - 12 years: Triage to ER if the ingested amount of Vyvanse (Lisdexamfetamine) exceeds 50 mg.
13 years - 64 years: Triage to ER if the ingested amount exceeds 60 mg.
65 years - 79 years: Triage to ER if the ingested amount of Vyvanse (Lisdexamfetamine) exceeds 40 mg.
Management: Most amphetamine related toxicity may be safely managed with supportive care that includes monitoring airway, breathing, and circulation, and control of agitation with benzodiazepines. Intravenous fluids may be needed for mild dehydration and mild hypotension, and sedation for agitation. Charcoal may be indicated if recent ingestion, airway controlled, and low seizure risk.
Poisoning cause: Severe Vyvanse (Lisdexamfetamine) toxicity
Toxic dose : The SPI triage threshold value for ingesting Vyvanse (Lisdexamfetamine) is as follows:
6 months - 5 years: Triage to ER if the ingested amount of Vyvanse (Lisdexamfetamine) is greater than 3 mg/kg OR exceeds 50 mg.
6 years - 12 years: Triage to ER if the ingested amount of Vyvanse (Lisdexamfetamine) exceeds 50 mg.
13 years - 64 years: Triage to ER if the ingested amount exceeds 60 mg.
65 years - 79 years: Triage to ER if the ingested amount of Vyvanse (Lisdexamfetamine) exceeds 40 mg.
Management:  Severe agitation requires aggressive treatment to avoid malignant hypertension, rhabdomyolysis, hyperthermia, and seizures. Large doses of benzodiazepines may be needed. Hyperthermia should be aggressively managed with evaporative or immersive cooling measures. Severe hyperthermia may require intubation and paralysis. For tachycardia, treat with intravenous fluids, sedation. Rhabdomyolysis is best treated with adequate 0.9% normal saline; monitor CK, electrolytes, and creatinine. Diuretics and urinary alkalinization are not recommended. Ventricular dysrhythmias should be treated with standard ACLS protocols. Coronary vasospasm can be treated with vasodilators (eg, nitrates and alpha-adrenergic receptor antagonists). Treat severe hypotension with IV 0.9% NaCl at 10 to 20 mL/kg. Add vasopressors (eg, norepinephrine) if unresponsive to fluids.
Poisoning cause: MILD TO MODERATE Lipitor (atorvastatin) toxicity
Toxic dose : 
	>25 mg/kg
Management: Treatment is symptomatic and supportive. Correct any significant fluid and/or electrolyte abnormalities in patients with vomiting or diarrhea.
Poisoning cause:  Severe Lipitor (atorvastatin) toxicity
Toxic dose : >25 mg/kg
Management:  Treatment is symptomatic and supportive. Severe toxicity is not expected after an overdose.Administer sufficient 0.9% saline to maintain urine output of at least 1 to 2 mL/kg/hr. Monitor input and output, serum electrolytes, CK, and renal function. Diuretics may be necessary to maintain urine output. Urinary alkalinization is NOT routinely recommended.
Poisoning cause: Bromdiphenhydramine
Toxic dose : toxic range in adult: > 37.5–125 mg
Poisoning cause: MILD TO MODERATE Carbinoxamine toxicity
Toxic dose : 6 months - 23 months	>0 mg
2 years - 5 years	>0.8 mg/kg OR >16 mg
6 years - 79 years	>0.8 mg/kg OR >32 mg.      toxic range: 12–40 mg
Poisoning cause: Severe Carbinoxamine toxicity
Toxic dose : 6 months - 23 months:	>0 mg,
2 years - 5 years:	>0.8 mg/kg OR >16 mg,
6 years - 79 years:	>0.8 mg/kg OR >32 mg.      toxic range: 12–40 mg
Poisoning cause: MILD TO MODERATE Clemastine toxicity
Toxic dose : 6 months - 5 years	>0.135 mg/kg OR >4.02 mg
6 years - 12 years	>6.03 mg
13 years - 60 years	>12.06 mg
61 years - 79 years	>6.03 mg      .toxic range: 2.01–13.4 mg
Poisoning cause: Severe Clemastine toxicity
Toxic dose : 6 months - 23 months:	>0 mg,
2 years - 5 years:	>0.8 mg/kg OR >16 mg,
6 years - 79 years:	>0.8 mg/kg OR >32 mg.      toxic range: 12–40 mg
Poisoning cause: MILD TO MODERATE Dimenhydrinate TOXICITY
Toxic dose : Over 7.5 mg/kg in children. toxic range in adults:	≥7.5 mg/kg OR ≥300 mgmg
Management: The majority of antihistamine Overdoses requires only supportive care; give activated charcoal if patient presents shortly after ingestion; sedate with benzodiazepines for agitation and delirium. Tachycardia is generally mild and well tolerated, and does not usually require specific treatment. Physostigmine can be used to establish a diagnosis, it may also help avoid an invasive, costly work-up, but should only be given in a setting where intensive monitoring and resuscitation are available. It should NOT be given if there is a history or ECG (QRS widening) evidence that suggests a tricyclic antidepressant poisoning.
Clinical effect 1: Drowsiness/lethargy
Clinical effect 2: Anticholinergic symptoms
Clinical effect 3: Mydriasis
Clinical effect 4: Flushing
Clinical effect 5: Fever/hyperthermia
Clinical effect 6: Dry mouth
Clinical effect 7: Decreased bowel sounds
Clinical effect 8: Tachycardia
Clinical effect 9: Hypertension
Clinical effect 10: Nausea
Clinical effect 11: Vomiting
Clinical effect 12: Agitation/Irritability/Restlessness
Clinical effect 13: Confusion
Clinical effect 14: Hallucinations
Poisoning cause: SEVERE Dimenhydrinate TOXICITY
Toxic dose : Over 7.5 mg/kg in children. toxic range in adults:>	≥7.5 mg/kg OR ≥300 mgmg
Management: Orotracheal intubation for airway protection should be performed early. Gastric lavage may be of benefit, if the patient presents soon after a large ingestion; administer activated charcoal as well. GI decontamination should be performed only in patients who can protect their airway or who are intubated. Severe delirium may develop and require large doses of benzodiazepines for sedation. Seizures (may rarely progress to status epilepticus) may require aggressive use of benzodiazepines, propofol and/or barbiturates. Monitor for QRS widening and ventricular dysrhythmias; treat with intravenous sodium bicarbonate (1 to 2 mEq/kg IV bolus starting dose, titrate to blood pH 7.45 to 7.55), or lidocaine if sodium bicarbonate unsuccessful. Monitor core temperature and treat hyperthermia with aggressive benzodiazepine sedation to control agitation and external cooling. Clinical manifestations may be prolonged due to delayed absorption in the setting of an anticholinergic ileus
Clinical effect 1: Agitated delirium
Clinical effect 2: Psychosis
Clinical effect 3: Seizure
Clinical effect 4: Coma
Clinical effect 5: Hypotension
Clinical effect 6: QRS widening
Clinical effect 7: Ventricular dysrhythmia
Clinical effect 8: Torsade de pointes
Clinical effect 9: Rhabdomyolysis
Clinical effect 10: Renal failure
Clinical effect 11: Agitation/Irritability/Restlessness
Poisoning cause: Diphenylpyraline:
Toxic dose : toxic range: 15–25 mg
Poisoning cause: MILD TO MODERATE Phenyltoloxamine toxicity
Toxic dose : toxic range: 150–250 mg. 6 months - 12 months:	>3 mg,
13 months - 5 years:	>6 mg,
6 years - 12 years:	>12 mg,
13 years - 79 years:	>180 mg
Poisoning cause: Severe Phenyltoloxamine toxicity
Toxic dose : toxic range: 150–250 mg. 6 months - 12 months:	>3 mg,
13 months - 5 years:	>6 mg,
6 years - 12 years:	>12 mg,
13 years - 79 years:	>180 mg
Poisoning cause: MILD TO MODERATE Pyrilamine toxicity
Toxic dose : toxic range: 75–250 mg.   <50 kg:	>37.5 mg,
≥50 kg:	>400 mg
Poisoning cause: Severe Pyrilamine toxicity
Toxic dose : toxic range: 75–250 mg.   <50 kg:	>37.5 mg,
≥50 kg:	>400 mg
Poisoning cause: Thenyldiamine: 
Toxic dose : toxic range: 30–50 mg
Poisoning cause: Tripelennamine
Toxic dose :  toxic range: 75–250 mg
Poisoning cause: MILD TO MODERATE Acrivastine toxicity
Toxic dose : toxic range: 24–40 mg .6 months - 11 years:	>8 mg,
12 years - 64 years:	>24 mg,
65 years - 79 years:	>16 mg
Poisoning cause: Severe Acrivastine toxicity
Toxic dose : toxic range: 24–40 mg .6 months - 11 years:	>8 mg,
12 years - 64 years:	>24 mg,
65 years - 79 years:	>16 mg
Poisoning cause: MILD TO MODERATE Brompheniramine toxicity
Toxic dose : toxic range: 12–40 mg. 6 months - 79 years:	>0.5 mg/kg
Poisoning cause: Severe Brompheniramine toxicity: 
Toxic dose : toxic range: 12–40 mg. 6 months - 79 years:	>0.5 mg/kg
Poisoning cause: MILD TO MODERATE Dexbrompheniramine toxicity
Toxic dose : toxic range: 6–20 mg .  6 months - 79 years:	>0.25 mg/kg
Poisoning cause:  Severe Dexbrompheniramine toxicity
Toxic dose : toxic range: 6–20 mg .  6 months - 79 years:	>0.25 mg/kg
Poisoning cause: MILD TO MODERATE Dexchlorpheniramine toxicity
Toxic dose : toxic range: 6–20 mg.  6 months - 79 years:	>0.25 mg/kg
Poisoning cause: Severe Dexchlorpheniramine toxicity
Toxic dose : toxic range: 6–20 mg.  6 months - 79 years:	>0.25 mg/kg
Poisoning cause: =A361
Toxic dose : toxic range: 3–10 mg
Poisoning cause: Pheniramine
Toxic dose : toxic range: 75–250 mg
Poisoning cause: Pyrrobutamine
Toxic dose : toxic range: 45–75 mg
Poisoning cause: Triprolidine:
Toxic dose : toxic range: 7.5–12.5 mg
Poisoning cause: Buclizine
Toxic dose : toxic range: 150–250 mg
Poisoning cause: Cinnarizine
Toxic dose : toxic range: 45–150 mg
Poisoning cause: Cyclizine:
Toxic dose : toxic range: 75–250 mg
Poisoning cause: Flunarizine: 
Toxic dose : toxic range: 15–50 mg
Poisoning cause: MILD TO MODERATE Meclizine toxicity
Toxic dose : toxic range: 75–250 mg. 6 months - 5 years:	>25 mg,
6 years - 11 years:	>50 mg,
12 years - 79 years:	>125 mg
Poisoning cause: Severe Meclizine toxicity
Toxic dose : toxic range: 75–250 mg. 6 months - 5 years:	>25 mg,
6 years - 11 years:	>50 mg,
12 years - 79 years:	>125 mg
Poisoning cause: MILD TO MODERATE  Promethazine toxicity
Toxic dose : toxic range: 75–250 mg.6 months - 23 months:	>5 mg,
2 years - 6 years:	>25 mg,
7 years - 15 years:	>50 mg,
16 years - 64 years:	>100 mg,
65 years - 79 years:	>25 mg
Poisoning cause: Severe Promethazine toxicity
Toxic dose : toxic range: 75–250 mg.6 months - 23 months:	>5 mg,
2 years - 6 years:	>25 mg,
7 years - 15 years:	>50 mg,
16 years - 64 years:	>100 mg,
65 years - 79 years:	>25 mg
Poisoning cause: Trimeprazine: 
Toxic dose : toxic range: 7.5–12.5 mg
Poisoning cause: MILD TO MODERATE Fluvoxamine toxicity
Toxic dose : 6 months - 79 years	>250 mg.    Per  Olson guideline  Over 500-3000 mg
Poisoning cause: Severe Fluvoxamine toxicity
Toxic dose : 6 months - 79 years	>250 mg.    Per  Olson guideline  Over 500-3000 mg
Poisoning cause: MILD TO MODERATE Nefazodone toxicity
Toxic dose : Per  Olson guideline  Over  1000-6000 mg
Poisoning cause: Severe Nefazodone toxicity
Poisoning cause: MILD TO MODERATE Methyldopa toxicity
Toxic dose : <50 kg:	>20 mg/kg OR >1.5 g,
≥50 kg:	>20 mg/kg OR >3 g Methyldopa. More than 2 g in adults is considered a toxic dose, and death was reported in an adult after an ingestion of 25 g. However, survival was re- ported after ingestion of 45 g. The therapeutic dose of methyldopa for children is 10–65 mg/kg/day, and the higher dose is expected to cause mild symp- toms.
Poisoning cause: Severe Methyldopa toxicity
Toxic dose : <50 kg:	>20 mg/kg OR >1.5 g,
≥50 kg:	>20 mg/kg OR >3 g Methyldopa. More than 2 g in adults is considered a toxic dose, and death was reported in an adult after an ingestion of 25 g. However, survival was re- ported after ingestion of 45 g. The therapeutic dose of methyldopa for children is 10–65 mg/kg/day, and the higher dose is expected to cause mild symp- toms.
Poisoning cause:  chlorthalidone
Toxic dose : the SPI triage threshold values for ingestion are:
6 months - 11 months: Triage to ER if ingested amount is greater than 1 mg/kg OR greater than 25 mg.
1 year - 12 years: Triage to ER if ingested amount is greater than 2 mg/kg OR greater than 100 mg.
13 years - 17 years: Triage to ER if ingested amount is greater than 100 mg.
18 years - 64 years: Triage to ER if ingested amount is greater than 200 mg.
65 years - 79 years: Triage to ER if ingested amount is greater than 25 mg.
Poisoning cause: MILD TO MODERATE Alkaline Corrosive toxicity
Management: Perform early (within 12 hours) endoscopy in patients with stridor, drooling, vomiting, significant oral burns, difficulty swallowing or abdominal pain, and in all patients with deliberate ingestion. If burns are absent or grade I severity, patient may be discharged when able to tolerate liquids and soft foods by mouth. If mild grade II burns, admit for intravenous fluids, slowly advance diet as tolerated. Perform barium swallow or repeat endoscopy several weeks after ingestion (sooner if difficulty swallowing) to evaluate for stricture formation.A) Obtain a complete blood count in symptomatic patients following an alkaline corrosive ingestion.
B) In patients with signs and symptoms suggesting severe burns, perforation, or bleeding (or adults with deliberate, high volume or high concentration ingestions), obtain renal function tests, serum electrolytes, INR, PTT, type and crossmatch for blood, and monitor urine output. Serum lactate and base deficit may also be useful in these patients. 
C) Monitor pulse oximetry or blood gases in patients with signs and symptoms suggestive of upper airway edema or burns.
D) Obtain an upright chest x-ray in patients with signs and symptoms suggesting severe burns, perforation, or bleeding (or adults with deliberate, high volume or high concentration ingestions) to evaluate for pneumomediastinum or free air under the diaphragm. The absence of these findings DOES NOT rule out the possibility of necrosis or perforation of the esophagus or stomach. Obtain a chest radiograph in patients with pulmonary signs or symptoms. 
E) Several weeks after ingestion, barium contrast radiographs of the upper GI tract are useful in patients who sustained grade II or III burns, to evaluate for strictures.
Poisoning cause: Severe Alkaline Corrosive toxicity
Management:  Resuscitate with 0.9% saline; blood products may be necessary. Early airway management in patients with upper airway edema or respiratory distress. Early (within 12 hours) gastrointestinal endoscopy to evaluate for burns. Early bronchoscopy in patients with respiratory distress or upper airway edema. Early surgical consultation for patients with severe grade II or grade III burns, large deliberate ingestions, or signs, symptoms or laboratory findings concerning for tissue necrosis or perforation.
Poisoning cause: MILD TO MODERATE wipes, kitchen, or disinfecting products toxicity
Toxic dose : For patients weighing less than 50 kg: Triage to ER if the ingested amount is greater than 1 mL per kg of body weight.
For patients weighing 50 kg or more: Triage to ER if the ingested amount is greater than 1 mL per kg of body weight OR if the total ingested amount is greater than 60 mL.
Management: The vast majority of exposures require only supportive care. The mouth should be rinsed and a small amount of water or milk given to patients with minor ingestions.   A) Most exposures do not require specific testing.
B) Obtain a CBC and monitor serum electrolytes and renal function in patients with concern for gastrointestinal (GI) burns.
C) Obtain a chest radiograph in patients with respiratory symptoms.
D) Obtain an upright chest radiograph if GI perforation is suspected, although a normal radiograph does not exclude perforation.
E) Endoscopy should be performed within 12 hours in patients in whom GI burns are a concern; deliberate ingestion of high concentration products can result in stridor, persistent vomiting, drooling, abdominal pain, or an inability to swallow.
Poisoning cause: Severe wipes, kitchen, or disinfecting products toxicity
Management: Evaluate for evidence of caustic injury to the gastrointestinal (GI) mucosa. Endoscopy should be performed within 12 hours in any patient with deliberate ingestion of a high concentration, or patients with stridor, pain with swallowing, or persistent vomiting. Administer intravenous fluids for hypotension and evaluate for GI bleeding. Maintain adequate ventilation and oxygenation; endotracheal intubation may be necessary in patients with upper airway edema or aspiration.A) Most exposures do not require specific testing.
B) Obtain a CBC and monitor serum electrolytes and renal function in patients with concern for gastrointestinal (GI) burns.
C) Obtain a chest radiograph in patients with respiratory symptoms.
D) Obtain an upright chest radiograph if GI perforation is suspected, although a normal radiograph does not exclude perforation.
E) Endoscopy should be performed within 12 hours in patients in whom GI burns are a concern; deliberate ingestion of high concentration products can result in stridor, persistent vomiting, drooling, abdominal pain, or an inability to swallow.
Poisoning cause: Pramipexole 
Toxic dose : Based on the triage information provided for Pramipexole ingestion across different age groups, the toxic dose thresholds can be outlined as follows:
6 months to 11 months: Greater than 1 mg
12 months to 5 years: Greater than 1 mg
6 years to 17 years: Greater than 1.5 mg
18 years to 64 years: Greater than 1.5 mg
65 years to 79 years: Greater than 1.5 mg
Poisoning cause: MILD TO MODERATE Valacyclovir toxicity
Toxic dose : Triage to ER if Valacyclovir  ingested amount meets these criteria:
Age Bracket	Amount
6 months - 11 years	>40 mg/kg OR >4 g
12 years - 64 years	>4 g
65 years - 79 years	>1.4 g
Management: Treatment is symptomatic and supportive. Rehydration (oral or IV fluids) may prevent crystalluria and nephrotoxicity reported with acyclovir. Treat significant vomiting and diarrhea with fluids as tolerated; treat with antiemetics for persistent vomiting. A) Monitor renal and CNS function as indicated following a significant exposure.
B) Monitor CBC, platelet count and renal and liver function tests in patients with suspected hemolytic uremic syndrome or thrombotic thrombocytopenic purpura.
Poisoning cause: Severe Valacyclovir toxicity
Management: Treatment is symptomatic and supportive. Rehydration (oral or IV fluids) may prevent crystalluria and nephrotoxicity reported with acyclovir. Support respiratory and cardiovascular function as needed. Benzodiazepines should be the first line agent for agitation or seizures. A) Monitor renal and CNS function as indicated following a significant exposure.
B) Monitor CBC, platelet count and renal and liver function tests in patients with suspected hemolytic uremic syndrome or thrombotic thrombocytopenic purpura.