SalioSAM/toxsample11 huggingface dataset:
Poisoning cause: MILD TO MODERATE Fexofenadine TOXICITY
Toxic dose : Over 300 mg
Management: The majority of antihistamine Overdoses requires only supportive care; give activated charcoal if patient presents shortly after ingestion; sedate with benzodiazepines for agitation and delirium. Tachycardia is generally mild and well tolerated, and does not usually require specific treatment. Physostigmine can be used to establish a diagnosis, it may also help avoid an invasive, costly work-up, but should only be given in a setting where intensive monitoring and resuscitation are available. It should NOT be given if there is a history or ECG (QRS widening) evidence that suggests a tricyclic antidepressant poisoning.
Clinical effect 1: Drowsiness/lethargy
Clinical effect 2: Anticholinergic symptoms
Clinical effect 3: Mydriasis
Clinical effect 4: Flushing
Clinical effect 5: Fever/hyperthermia
Clinical effect 6: Dry mouth
Clinical effect 7: Decreased bowel sounds
Clinical effect 8: Tachycardia
Clinical effect 9: Hypertension
Clinical effect 10: Nausea
Clinical effect 11: Vomiting
Clinical effect 12: Agitation/Irritability/Restlessness
Clinical effect 13: Confusion
Clinical effect 14: Hallucinations
Poisoning cause: SEVERE Fexofenadine TOXICITY
Toxic dose : Over 300 mg
Management: Orotracheal intubation for airway protection should be performed early. Gastric lavage may be of benefit, if the patient presents soon after a large ingestion; administer activated charcoal as well. GI decontamination should be performed only in patients who can protect their airway or who are intubated. Severe delirium may develop and require large doses of benzodiazepines for sedation. Seizures (may rarely progress to status epilepticus) may require aggressive use of benzodiazepines, propofol and/or barbiturates. Monitor for QRS widening and ventricular dysrhythmias; treat with intravenous sodium bicarbonate (1 to 2 mEq/kg IV bolus starting dose, titrate to blood pH 7.45 to 7.55), or lidocaine if sodium bicarbonate unsuccessful. Monitor core temperature and treat hyperthermia with aggressive benzodiazepine sedation to control agitation and external cooling. Clinical manifestations may be prolonged due to delayed absorption in the setting of an anticholinergic ileus. OBSERVATION CRITERIA of Fexofenadine TOXICITY: Patients with deliberate ingestions and symptomatic patients should be sent to a health care facility for observation for 6 to 8 hours. A patient with a deliberate Overdose requires a psychiatric evaluation prior to discharge.
Clinical effect 1: Agitated delirium
Clinical effect 2: Psychosis
Clinical effect 3: Seizure
Clinical effect 4: Coma
Clinical effect 5: Hypotension
Clinical effect 6: QRS widening
Clinical effect 7: Ventricular dysrhythmia
Clinical effect 8: Torsade de pointes
Clinical effect 9: Rhabdomyolysis
Clinical effect 10: Renal failure
Clinical effect 11: Agitation/Irritability/Restlessness
Poisoning cause: MILD TO MODERATE Desloratadine TOXICITY
Toxic dose : Over 300 mg
Management: Somnolence, anticholinergic effects (ie, mydriasis, flushing, fever, dry mouth, and decreased bowel sounds), tachycardia, mild hypertension, and nausea and vomiting are common after Overdose. Agitation, confusion, and hallucinations may develop with moderate poisoning.
Clinical effect 1: Drowsiness/lethargy
Clinical effect 2: Anticholinergic symptoms
Clinical effect 3: Mydriasis
Clinical effect 4: Flushing
Clinical effect 5: Fever/hyperthermia
Clinical effect 6: Dry mouth
Clinical effect 7: Decreased bowel sounds
Clinical effect 8: Tachycardia
Clinical effect 9: Hypertension
Clinical effect 10: Nausea
Clinical effect 11: Vomiting
Clinical effect 12: Agitation/Irritability/Restlessness
Clinical effect 13: Confusion
Clinical effect 14: Hallucinations
Poisoning cause: SEVERE Desloratadine TOXICITY
Toxic dose : Over 300 mg
Management: Severe effects may include agitated delirium, psychosis, seizures, coma, hypotension, QRS widening, and ventricular dysrhythmias, including torsade de pointe but are generally only reported in adults after very large, deliberate ingestions. Rhabdomyolysis and renal failure may rarely develop in patients with prolonged agitation, coma, or seizures.
Clinical effect 1: Agitated delirium
Clinical effect 2: Psychosis
Clinical effect 3: Seizure
Clinical effect 4: Coma
Clinical effect 5: Hypotension
Clinical effect 6: QRS widening
Clinical effect 7: Ventricular dysrhythmia
Clinical effect 8: Torsade de pointes
Clinical effect 9: Rhabdomyolysis
Clinical effect 10: Renal failure
Clinical effect 11: Agitation/Irritability/Restlessness
Poisoning cause: MILD TO MODERATE Loratadine TOXICITY
Toxic dose : Over 300 mg
Management: The majority of antihistamine Overdoses requires only supportive care; give activated charcoal if patient presents shortly after ingestion; sedate with benzodiazepines for agitation and delirium. Tachycardia is generally mild and well tolerated, and does not usually require specific treatment. Physostigmine can be used to establish a diagnosis, it may also help avoid an invasive, costly work-up, but should only be given in a setting where intensive monitoring and resuscitation are available. It should NOT be given if there is a history or ECG (QRS widening) evidence that suggests a tricyclic antidepressant poisoning.
Clinical effect 1: Drowsiness/lethargy
Clinical effect 2: Anticholinergic symptoms
Clinical effect 3: Mydriasis
Clinical effect 4: Flushing
Clinical effect 5: Fever/hyperthermia
Clinical effect 6: Dry mouth
Clinical effect 7: Decreased bowel sounds
Clinical effect 8: Tachycardia
Clinical effect 9: Hypertension
Clinical effect 10: Nausea
Clinical effect 11: Vomiting
Clinical effect 12: Agitation/Irritability/Restlessness
Clinical effect 13: Confusion
Clinical effect 14: Hallucinations
Poisoning cause: SEVERE Loratadine TOXICITY
Toxic dose : Over 300 mg
Management: Orotracheal intubation for airway protection should be performed early. Gastric lavage may be of benefit, if the patient presents soon after a large ingestion; administer activated charcoal as well. GI decontamination should be performed only in patients who can protect their airway or who are intubated. Severe delirium may develop and require large doses of benzodiazepines for sedation. Seizures (may rarely progress to status epilepticus) may require aggressive use of benzodiazepines, propofol and/or barbiturates. Monitor for QRS widening and ventricular dysrhythmias; treat with intravenous sodium bicarbonate (1 to 2 mEq/kg IV bolus starting dose, titrate to blood pH 7.45 to 7.55), or lidocaine if sodium bicarbonate unsuccessful. Monitor core temperature and treat hyperthermia with aggressive benzodiazepine sedation to control agitation and external cooling. Clinical manifestations may be prolonged due to delayed absorption in the setting of an anticholinergic ileus. OBSERVATION CRITERIA of Loratadine TOXICITY: Patients with deliberate ingestions and symptomatic patients should be sent to a health care facility for observation for 6 to 8 hours. A patient with a deliberate Overdose requires a psychiatric evaluation prior to discharge
Clinical effect 1: Agitated delirium
Clinical effect 2: Psychosis
Clinical effect 3: Seizure
Clinical effect 4: Coma
Clinical effect 5: Hypotension
Clinical effect 6: QRS widening
Clinical effect 7: Ventricular dysrhythmia
Clinical effect 8: Torsade de pointes
Clinical effect 9: Rhabdomyolysis
Clinical effect 10: Renal failure
Clinical effect 11: Agitation/Irritability/Restlessness
Poisoning cause: Mild to Moderate Captopril Toxicity
Toxic dose : Over 100 mg (child)
Management: Most patients will have no symptoms, but patients with mild orthostatic hypotension can be treated by remaining prone. Those who remain hypotensive can be treated with IV fluids
Clinical effect 1: Hypotension
Poisoning cause: Severe Captopril Toxicity
Toxic dose : Over 100 mg (child)
Management: Adequate circulatory support with IV fluids and vasopressors (if needed) should be assured if the patient presents with circulatory collapse. Correct severe hyperkalemia using standard treatments such as glucose, insulin, calcium, sodium bicarbonate, sodium polystyrene sulfate and hemodialysis.
Clinical effect 1: Hypotension
Clinical effect 2: Syncope
Clinical effect 3: Hyperkalemia
Clinical effect 4: Bradycardia
Clinical effect 5: Renal failure
Poisoning cause: Mild to Moderate Enalapril Toxicity
Toxic dose : Over 30 mg (child)
Management: Most patients will have no symptoms, but patients with mild orthostatic hypotension can be treated by remaining prone. Those who remain hypotensive can be treated with IV fluids. 
Clinical effect 1: Hypotension
Poisoning cause: Severe Enalapril Toxicity
Toxic dose : Over 30 mg (child)
Management: Adequate circulatory support with IV fluids and vasopressors (if needed) should be assured if the patient presents with circulatory collapse. Correct severe hyperkalemia using standard treatments such as glucose, insulin, calcium, sodium bicarbonate, sodium polystyrene sulfate and hemodialysis.
Clinical effect 1: Hypotension
Clinical effect 2: Syncope
Clinical effect 3: Hyperkalemia
Clinical effect 4: Bradycardia
Clinical effect 5: Renal failure
Poisoning cause: Mild to Moderate Fosinopril Toxicity
Toxic dose : Over 30 mg (child)
Management: Most patients will have no symptoms, but patients with mild orthostatic hypotension can be treated by remaining prone. Those who remain hypotensive can be treated with IV fluids. 
Clinical effect 1: Hypotension
Poisoning cause: Severe Fosinopril Toxicity
Toxic dose : Over 30 mg (child)
Management: Adequate circulatory support with IV fluids and vasopressors (if needed) should be assured if the patient presents with circulatory collapse. Correct severe hyperkalemia using standard treatments such as glucose, insulin, calcium, sodium bicarbonate, sodium polystyrene sulfate and hemodialysis
Clinical effect 1: Hypotension
Clinical effect 2: Syncope
Clinical effect 3: Hyperkalemia
Clinical effect 4: Bradycardia
Clinical effect 5: Renal failure
Poisoning cause: Mild to Moderate Lisinopril Toxicity
Toxic dose : Age Group: 6 months to 7 years: Greater than 4 mg/kg of body weight OR a total dose exceeding 40 mg of Lisinopril.
Age Group: 8 years to 18 years: Greater than 60 mg of Lisinopril.
Age Group: 19 years to 79 years: Greater than 80 mg of Lisinopril
Management: Most patients will have no symptoms, but patients with mild orthostatic hypotension can be treated by remaining prone. Those who remain hypotensive can be treated with IV fluids. 
Clinical effect 1: Hypotension
Poisoning cause: Severe Lisinopril Toxicity
Toxic dose : Age Group: 6 months to 7 years: Greater than 4 mg/kg of body weight OR a total dose exceeding 40 mg of Lisinopril.
Age Group: 8 years to 18 years: Greater than 60 mg of Lisinopril.
Age Group: 19 years to 79 years: Greater than 80 mg of Lisinopril
Management: Adequate circulatory support with IV fluids and vasopressors (if needed) should be assured if the patient presents with circulatory collapse. Correct severe hyperkalemia using standard treatments such as glucose, insulin, calcium, sodium bicarbonate, sodium polystyrene sulfate and hemodialysis.
Clinical effect 1: Hypotension
Clinical effect 2: Syncope
Clinical effect 3: Hyperkalemia
Clinical effect 4: Bradycardia
Clinical effect 5: Renal failure
Poisoning cause: Mild to Moderate Ramipril Toxicity
Toxic dose : Over 5 mg
Management: Most patients will have no symptoms, but patients with mild orthostatic hypotension can be treated by remaining prone. Those who remain hypotensive can be treated with IV fluids. 
Clinical effect 1: Hypotension
Poisoning cause: Severe Ramipril Toxicity
Toxic dose : Over 5 mg
Management: Adequate circulatory support with IV fluids and vasopressors (if needed) should be assured if the patient presents with circulatory collapse. Correct severe hyperkalemia using standard treatments such as glucose, insulin, calcium, sodium bicarbonate, sodium polystyrene sulfate and hemodialysis.
Clinical effect 1: Hypotension
Clinical effect 2: Syncope
Clinical effect 3: Hyperkalemia
Clinical effect 4: Bradycardia
Clinical effect 5: Renal failure
Poisoning cause: Mild to Moderate Trandolapril Toxicity
Toxic dose : Over 4 mg
Management: Most patients will have no symptoms, but patients with mild orthostatic hypotension can be treated by remaining prone. Those who remain hypotensive can be treated with IV fluids
Clinical effect 1: Hypotension
Poisoning cause: Severe Trandolapril Toxicity
Toxic dose : Over 4 mg
Management: Adequate circulatory support with IV fluids and vasopressors (if needed) should be assured if the patient presents with circulatory collapse. Correct severe hyperkalemia using standard treatments such as glucose, insulin, calcium, sodium bicarbonate, sodium polystyrene sulfate and hemodialysis
Clinical effect 1: Hypotension
Clinical effect 2: Syncope
Clinical effect 3: Hyperkalemia
Clinical effect 4: Bradycardia
Clinical effect 5: Renal failure
Poisoning cause: Mild to Moderate Amoxicillin Toxicity
Toxic dose : Over 250 mg/kg
Management: Treatment is symptomatic and supportive. Treat significant vomiting and diarrhea with IV fluids; administer antiemetics, as needed. HYPERSENSITIVITY REACTION: Administer antihistamines, with or without inhaled beta agonists, corticosteroids or epinephrine. 
Clinical effect 1: Nausea
Clinical effect 2: Vomiting
Clinical effect 3: Abdominal pain
Clinical effect 4: Diarrhea
Clinical effect 5: Skin rashes
Clinical effect 6: Urticaria
Clinical effect 7: Hematuria
Clinical effect 8: Crystalluria
Clinical effect 9: Transient renal insufficiency
Poisoning cause: Severe Oral Amoxicillin Toxicity
Toxic dose : Over 250 mg/kg
Management: Acute anaphylaxis is more likely to occur after parenteral exposure, but may develop with all routes. Administer oxygen, aggressive airway management, antihistamines, epinephrine, corticosteroids, ECG monitoring, and IV fluids. Dysrhythmias should be treated with standard antiarrhythmic drugs, if necessary. SEIZURES: Initially treat with IV benzodiazepines.
Clinical effect 1: Agitation/Irritability/Restlessness
Clinical effect 2: Confusion
Clinical effect 3: Hallucinations
Clinical effect 4: Stupor
Clinical effect 5: Coma
Clinical effect 6: Multifocal myoclonus
Clinical effect 7: Seizure
Clinical effect 8: Death
Clinical effect 9: Hyperkalemia
Poisoning cause: Mild to Moderate Ampicillin Toxicity
Toxic dose : Over 250 mg/kg
Management: Treatment is symptomatic and supportive. Treat significant vomiting and diarrhea with IV fluids; administer antiemetics, as needed. HYPERSENSITIVITY REACTION: Administer antihistamines, with or without inhaled beta agonists, corticosteroids or epinephrine
Clinical effect 1: Nausea
Clinical effect 2: Vomiting
Clinical effect 3: Abdominal pain
Clinical effect 4: Diarrhea
Clinical effect 5: Skin rashes
Clinical effect 6: Urticaria
Poisoning cause: Severe Ampicillin Toxicity
Toxic dose : Over 250 mg/kg
Management: Acute anaphylaxis is more likely to occur after parenteral exposure, but may develop with all routes. Administer oxygen, aggressive airway management, antihistamines, epinephrine, corticosteroids, ECG monitoring, and IV fluids. Dysrhythmias should be treated with standard antiarrhythmic drugs, if necessary. SEIZURES: Initially treat with IV benzodiazepines
Clinical effect 1: Agitation/Irritability/Restlessness
Clinical effect 2: Confusion
Clinical effect 3: Hallucinations
Clinical effect 4: Stupor
Clinical effect 5: Coma
Clinical effect 6: Multifocal myoclonus
Clinical effect 7: Seizure
Clinical effect 8: Delirium/encephalopathy
Poisoning cause: Mild to Moderate Ethylene Glycol Toxicity
Toxic dose : Over 10 cc, 2000 mg (adult), 10 mL (adult), 1 swallow (adult), 1 taste or lick (child)
Toxic serum or urine levels: Over 25 mg/dL
Management: Monitor serum electrolytes, renal function and ethylene glycol concentration. A peak ethylene glycol concentration < 20 mg/dL is commonly considered nontoxic. If the serum ethylene glycol concentration is >20 mg/dL, or there is a metabolic acidosis, or a history of a potentially toxic ingestion and ethylene glycol concentration is not rapidly available, administer an alcohol dehydrogenase inhibitor (either fomepizole or ethanol). In patients who present early after ingestion (before the development of metabolic acidosis), no further treatment may be required.
Clinical effect 1: Drowsiness/lethargy
Clinical effect 2: Confusion
Clinical effect 3: Agitation/Irritability/Restlessness
Clinical effect 5: Inebriated appearance
Clinical effect 6: Nausea
Clinical effect 7: Vomiting
Poisoning cause: Severe Ethylene Glycol Toxicity
Toxic dose : Over 10 cc, 2000 mg (adult), 10 mL (adult), 1 swallow (adult), 1 taste or lick (child)
Toxic serum or urine levels: Over 25 mg/dL
Management: CNS depression may require intubation; adequate minute ventilation must be insured to prevent abrupt worsening of acidemia. Alcohol-induced vasodilation and vomiting may lead to hypotension requiring fluid resuscitation. Alcohol dehydrogenase (ADH) inhibition is the most specific treatment for patients with severe ethylene glycol toxicity. Blockade (using fomepizole or ethanol) allows for excretion of ethylene glycol without formation of toxic metabolites (ADH has a much higher affinity for ethanol or fomepizole than for ethylene glycol). In patients who present late with metabolic acidosis and for most patients with very high ethylene glycol concentrations, hemodialysis will be necessary after ADH inhibition. Hemodialysis is the most definitive therapy for ethylene glycol poisoning as it clears both ethylene glycol and its toxic metabolites from the blood and corrects any resulting metabolic acidosis. Indications for hemodialysis include metabolic acidosis (serum pH < 7.2), signs of end-organ toxicity (eg, seizures and coma), and renal failure. Thiamine and pyridoxine are also administered to encourage metabolism of ethylene glycol to less toxic metabolites
Clinical effect 1: CNS depression
Clinical effect 2: Coma
Clinical effect 3: Hypotonia
Clinical effect 4: Hyporeflexia
Clinical effect 5: Cerebral edema
Clinical effect 6: Anion gap increase
Clinical effect 7: Seizure
Clinical effect 8: Tachycardia
Clinical effect 9: Kussmaul respirations
Clinical effect 10: Hypotension
Clinical effect 11: Hypocalcemia
Clinical effect 12: Dysrhytmia
Clinical effect 13: Renal failure
Clinical effect 14: Acidosis
Poisoning cause: Mild to Moderate Benzocaine Toxicity
Toxic dose : Over 100 mg (child)
Management: Patients with mild to moderate toxicity can be treated with supportive care. Intravenous fluids should be given to maintain urine output and supplemental oxygen applied
Clinical effect 1: Methemoglobinemia
Clinical effect 2: Cyanosis unresponsive to supplemental oxygen
Clinical effect 3: Significant cyanosis in a patient with minimal symptoms
Poisoning cause: Severe Benzocaine Toxicity
Toxic dose : Over 100 mg (child)
Management: Patients with evidence of end-organ ischemia should be treated with methylene blue regardless of the methemoglobin concentration. However, patients are unlikely to have end-organ ischemia with concentrations less than 20%. Treatment with methylene blue should result in resolution of all symptoms attributable to methemoglobinemia within 2 hours. Patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency or children younger than 3 months may require exchange transfusion or treatment with hyperbaric oxygen as they may not respond to methylene blue. Treat seizures with IV benzodiazepines or barbiturates.
Clinical effect 1: Methemoglobinemia > 30%
Poisoning cause: Mild to Moderate Aripiprazole Toxicity
Toxic dose : Over 15 mg (under 12 years old and acute), 50 mg (Over 12 years old and acute)
Management: For management of mild to moderate toxicity, good supportive care is all that is needed. Treatment may include fluids and antiemetics for patients with nausea and vomiting or benzodiazepines for agitation. For drug-induced dystonia, treatment includes benztropine and diphenhydramine
Clinical effect 1: Drowsiness/lethargy
Clinical effect 2: Tachycardia
Clinical effect 3: Tremors
Clinical effect 4: Agitation/Irritability/Restlessness
Clinical effect 5: Nausea
Clinical effect 6: Vomiting
Poisoning cause: Severe Aripiprazole Toxicity
Toxic dose : Over 15 mg (under 12 years old and acute), 50 mg (Over 12 years old and acute)
Management: Mainstay of treatment is good supportive care, including airway management for patients with severe CNS sedation and fluid and vasopressors for hypotension. For patients with neuroleptic malignant syndrome, standard treatments include sedation with benzodiazepines, bromocriptine, and dantrolene (used in severe cases), and good supportive care including cooling methods for hyperthermia.
Clinical effect 1: Hypotension
Clinical effect 2: Coma
Clinical effect 3: Neuroleptic malignant syndrome
Poisoning cause: Mild to Moderate Ibuprofen Toxicity
Toxic dose : Over 200 mg/kg (mild to moderate)
Management: Most ibuprofen toxicity resolves with supportive care. Otherwise healthy patients with a history of ibuprofen poisoning generally require only supportive care and fluid and electrolyte replacement
Clinical effect 1: Asymptomatic
Clinical effect 2: Abdominal pain
Clinical effect 3: Nausea
Clinical effect 4: Vomiting
Clinical effect 6: CNS depression
Clinical effect 7: Drowsiness/lethargy
Clinical effect 8: Headache
Clinical effect 9: Nystagmus
Clinical effect 10: Diplopia
Clinical effect 11: Tinnitus
Clinical effect 12: Transient deafness
Poisoning cause: Severe Ibuprofen Toxicity
Toxic dose : Over 400 mg/kg
Management: Maintain an open airway and support ventilation. Treat seizures with benzodiazepines, hypotension with fluids and adrenergic vasopressors, and coma with intubation. Monitor ECG and arterial blood gases in patients with severe toxicity. 
Clinical effect 1: Seizure
Clinical effect 2: Coma
Clinical effect 3: Renal failure
Clinical effect 4: Cardiac arrest 
Clinical effect 5: Upper GI bleeding
Clinical effect 7: Moderate Elevation of serum transaminase (100<ALT,AST<1000 ) 
Clinical effect 8: Hypoprothrombinemia
Clinical effect 9: Acidosis
Clinical effect 10: Hypokalemia
Clinical effect 11: Hypophosphatemia
Clinical effect 12: Hyponatremia
Clinical effect 13: Hyperkalemia
Clinical effect 15: Hypotension
Clinical effect 16: Bradycardia
Clinical effect 17: Tachycardia
Clinical effect 18: Atrial fibrillation
Clinical effect 19: Dyspnea
Clinical effect 20: Aspiration pneumonia
Clinical effect 21: Rhabdomyolysis
Clinical effect 22: Disseminated intravascular coagulation
Clinical effect 23: Respiratory arrest
Clinical effect 24: Acute pancreatitis
Clinical effect 25: Profound shock
Clinical effect 26: Multiorgan failure
Poisoning cause: Mild to Moderate Felodipine Toxicity
Toxic dose : Over 10 mg (adult), 0.3 mg/kg (child)
Management: Patients who have asymptomatic bradycardia can be admitted and observed with telemetry. Obtain peripheral intravenous access and monitor ECG. Mild hypotension may only require treatment with intravenous fluid administration.
Clinical effect 1: Hypotension
Clinical effect 2: Dizziness
Clinical effect 3: Syncope
Clinical effect 4: Reflex tachycardia
Clinical effect 5: Angina pectoris