In this "critically acclaimed psychological thriller based on true events, Gabriel (Robin Williams), a celebrated writer and late-night talk show host, becomes captivated by the harrowing story of a young listener and his adoptive mother (Toni Collette). When troubling questions arise about this boy's (story), however, Gabriel finds himself drawn into a widening mystery that hides a deadly secret" according to film's official synopsis.
You really should STOP reading these comments, and watch the film NOW...
The "How did he lose his leg?" ending, with Ms. Collette planning her new life, should be chopped off, and sent to "deleted scenes" land. It's overkill. The true nature of her physical and mental ailments should be obvious, by the time Mr. Williams returns to New York. Possibly, her blindness could be in question - but a revelation could have be made certain in either the "highway" or "video tape" scenes. The film would benefit from a re-editing - how about a "director's cut"?
Williams and Bobby Cannavale (as Jess) don't seem, initially, believable as a couple. A scene or two establishing their relationship might have helped set the stage. Otherwise, the cast is exemplary. Williams offers an exceptionally strong characterization, and not a "gay impersonation". Sandra Oh (as Anna), Joe Morton (as Ashe), and Rory Culkin (Pete Logand) are all perfect.
Best of all, Collette's "Donna" belongs in the creepy hall of fame. Ms. Oh is correct in saying Collette might be, "you know, like that guy from 'Psycho'." There have been several years when organizations giving acting awards seemed to reach for women, due to a slighter dispersion of roles; certainly, they could have noticed Collette with some award consideration. She is that good. And, director Patrick Stettner definitely evokes Hitchcock - he even makes getting a sandwich from a vending machine suspenseful.
Finally, writers Stettner, Armistead Maupin, and Terry Anderson deserve gratitude from flight attendants everywhere.
******* The Night Listener (1/21/06) Patrick Stettner ~ Robin Williams, Toni Collette, Sandra Oh, Rory Culkin

This film about secret government mind experiments and the corrupt use of the citizenry by secretive and vile shadowy figures had the potential for being a really interesting movie. But for me, it failed. I won't elaborate much on the rather confusing plot line, but if you are looking for a detailed explanation, the comment by user "reluctantpopstar" gives a good description of it.
But it didn't work for me. I found it slow, which would be okay but for the fact that it seemed to go nowhere. The viewer is left in the dark about too many things to really be able to get a handle on this movie-in some films, one can argue that the filmmakers intended to provoke thought and left things ambiguous for that reason. I don't think that this is the case here.
As for the frequent long shots of two buildings that have been frequently mentioned by other users...I see that they do have a point-they give the viewer time to get another drink without missing any of the "action". And I suspect many viewers would welcome the opportunity to have several beverages on board to get through this one.