Director Vincenzo Natali first showed his penchant for character-based sci-fi flicks with his 1997 short film "Elevated", wherein 3 people remain trapped in an elevator while unseen monsters roam the building. His follow-up feature project "Cube", released later that year, had a very similar premise, this time with 6 people and instead of an elevator it was a vast expansion of interlocking cubic deathtraps. Both were admirable attempts to take the sci-fi genre a step further, by deliberately declining to show almost any visual stimulation, choosing instead to spend as much time as possible focusing on the human element, how the characters act, react and interact under incomprehensible and dangerous conditions. After his exploration into the mainstream with 2002's "Cypher", Natali has come back to his bizarre character-film trend to bring us "Nothing", his latest, and by far most optimistic and comedic take on the wide cinematic world of "What If?"
Dave (David Hewlett) and Andrew (Andrew Miller) are life-long friends, brought together by a mutual detachment from society and a lack of any one else to be with. Dave, who has always been hindered by a selfish and somewhat dimwitted nature, lives rent-free with Andrew at his ill-located and ill-constructed house, where he often takes advantage of Andrew's neurotic and antisocial mentality. Despite all this, the two misfits are happy together, until one day their deep character flaws, coupled with some astronomically bad luck, land them in the middle of some pretty serious, jail-sentence-worthy trouble. On top of this, they discover that their house has been deemed unfit for existence and is scheduled to be demolished before sunset, so in the hazy, nightmarish panic of everything going wrong for them, they wish that the whole world would just disappear. And it does.
Going any further with the synopsis would compromise a lot of the film's slow (occasionally too slow) reveal about what's happened to Dave and Andrew, and how they deal with their new reality. Natali's fascination with studying human behavior under duress (ala The Birds) is here in spades, but simply by making the main characters friends rather than strangers, he's able to break away from the thriller-horror element of this premise to open it up to a more comfortable and optimistic level. It's almost as if he's made the aphoristic opposite of "Cube".
Of course, the film is not 85 minutes of laughter and sunshine. In keeping with fundamental realism, our two anti-heroes' dynamic often becomes antagonistic, sometimes with rather nasty results. Like the "Desert Island" game, the film looks at how even best friends, when left alone together, can fall apart, but at the same time it shows that friends are vital to the quality of existence. In a very twisted, sci-fi way, this is a feel-good flick, with good heart and good intentions.
However, there are a few qualms to be had with "Nothing". While the two lead actors, Hewlett and Miller, do well with their parts, their characters are not nearly as interesting as they should have been, considering it is completely up to them to entertain us for the better part of an hour. There is some development in the relationship and personalities of Dave and Andrew, some background is given, but ultimately not enough. A generous viewer will sit through the less-engaging portions of the film to see it through to the end, but cynics will probably give up pretty fast.
Acting, as mentioned, is adequate, and considering the amount of 'green-screen' work that would've been needed, reasonably convincing. David Hewlett and Andrew Miller, who both wrote co-wrote the screenplay, have been long-time friends of Vincenzo Natali: Hewlett has in fact featured in every film Natali has made. Perhaps it was their creative input that steered this film in a more positive direction. Nonetheless, the story could have been a lot more involving. Granted, it is relatively entertaining considering that (no pun intended) nothing really happens, but you get the impression that, in more experienced hands, a lot more could've been done with this premise.
In all fairness, "Nothing" is an impressive piece of work in many ways. The concept is interesting, the direction is inventive, the script works on a human level and, most of all, it shows a progression in Natali's creative mentality. For fans of his work, this will be a delight, and for others it will be a nice way to pass a little unwanted time. It's just a shame that the director's fixation on human drama prevented it from being the great, fun film it could have been.

Apparently none of the previous reviewers,most of whom praise the film for its accuracy, have actually read a biography of Louis Pasteur.The most glaring inaccuracy is in the relationship between Pasteur and Napoleon III.Back in the 1930's the latter was invariably shown in a bad light.While far from an admirable character-he was an inept politician and a self-appointed "military genius" who allowed France to be dragged into a disastrous war,he was not the stupid reactionary depicted here. He had an intelligent interest in science,and like many other people in the 19th century saw a bright future because of the improvements it would bring.Far from exiling Pasteur, he was his PATRON,building him a laboratory and providing him with all the resources that he needed for his research.While the lab was under construction, Pasteur became gravely ill.A bureaucrat, deciding it was a waste of money to build a laboratory for someone who would soon be dead, ordered work halted on his own authority.When the emperor heard about this, his outrage shook the bureaucracy so that there was a flurry of buck-passing, and work promptly resumed.The Emperor personally visited Pasteur to comfort him and reassure him that he would get his lab.The emperor would often bring members of his court to admire Pasteur's projects,and it was obvious to everyone that Pasteur was one of the emperor's favorites.Pasteur's main worry concerning the Emperor was that Napoleon thought Pasteur was virtually a miracle worker who could do almost anything, and was constantly assigning him tasks outside of his previous experience.Pasteur, a very modest man, was always protesting this, but Napoleon would say that he had complete faith in him,and Pasteur despite his misgivings, always came through.They always had a close and friendly relationship,and after the Emperor was overthrown, Pasteur refused to say a bad word about him,grateful to the end of his life.
The part about his daughter having the baby, and Pasteur sacrificing his principles to get a doctor, never happened.The part about the anthrax and rabies, for which he was famous, is generally correct, but the notion that the anthrax experiment raised him from obscurity to fame is false.He was famous and respected at the time this happened.This movie is OK from a dramatic standpoint,but very distorted as biography.